text:
Manganese Gluconate Dihydrate USP/FCC Fine Powder
Jost Code: 2576
Synonyms: manganese (II) gluconate dihydrate
Manganese Gluconate can be used as a dietary supplement and as a nutrient. Manganese is important in the breakdown of amino acids and the production of energy. It activates various enzymes for proper digestion and utilization of foods. Manganese also helps nourish the nerves and brain and is necessary for normal skeletal development. Product specifications, SDSs and certifications are available under Additional Information.
Technical Information
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Int J Vitam Nutr Res.. 2007 Jul
A bioavailability study comparing two oral formulations containing zinc (Zn bis-glycinate vs. Zn gluconate) after a single administration to twelve healthy female volunteers.
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Biol Trace Elem Res.. 1988 Aug
Effects of zinc-aspartate and zinc-glycinate in healthy rats and on reserpine-induced gastric lesions.
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Biol Trace Elem Res.. 2016 Jun
Dosage Effect of Zinc Glycine Chelate on Zinc Metabolism and Gene Expression of Zinc Transporter in Intestinal Segments on Rat.
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Biol Trace Elem Res.. 2018 Feb
Effects of Maternal Zinc Glycine on Mortality, Zinc Concentration, and Antioxidant Status in a Developing Embryo and 1-Day-Old Chick.
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Biol Trace Elem Res.. 2017 Aug
Effects of Zinc Glycinate on Productive and Reproductive Performance, Zinc Concentration and Antioxidant Status in Broiler Breeders.
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J Anim Physiol Anim Nutr (Berl).. 2006 Jun
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J Colloid Interface. 2004 Apr
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J Exp Clin Cancer Res.. 2019 Jun
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Acta Med Okayama. . 2018 Oct
Effect of Zinc Acetate Dihydrate (NobelzinR) Treatment on Anemia and Taste Disorders in Patients with Chronic Kidney Disease with Hypozincemia
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Br J Clin Pharmacol.. 2016 Nov
Zinc acetate lozenges for treating the common cold: an individual patient data meta-analysis.
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BMC Fam Pract. . 2015 Feb
The effectiveness of high dose zinc acetate lozenges on various common cold symptoms: a meta-analysis.
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Ultrason Sonochem. 2017 Mar
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Ann Pharmacother.. 1998 Jan
Zinc acetate treatment in Wilson's disease
OBJECTIVE: To briefly review the pathophysiology and diagnosis of Wilson's disease, and to evaluate the pharmacology, pharmacokinetics, clinical utility, adverse effects, dosing regimens, and pharmacoeconomics of zinc acetate therapy in Wilson's disease. DATA SOURCES: A MEDLINE search (December 1966-December 1996) of the English-language literature using the terms zinc and Wilson's disease was conducted to identify… Read Abstract
Drug Deliv Transl Res. . 2017 Dec
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Clin Infect Dis.. 2000 Nov
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Equine Vet J.. 2019 Sep
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Am J Vet Res.. 1996 Dec
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Send to Poult Sci.. 2012 May
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Send to Eur J Hosp Pharm.. 2015 May
Stability of octreotide acetate decreases in a sodium bisulfate concentration-dependent manner: compatibility study with morphine and metoclopramide injections.
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Poult Sci.. 2015 Dec
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Mediators Inflamm.. 1970 Jan
Andrographolide Sodium Bisulfate Prevents UV-Induced Skin Photoaging through Inhibiting Oxidative Stress and Inflammation.
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Chem Pharm Bull (Tokyo).. 2018 Jan
Tofogliflozin Salt Cocrystals with Sodium Acetate and Potassium Acetate
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Food Chem.. 2018 Aug
Nitrite Accumulation Characteristics of Partial Denitrification in Different Sludge Sources Using Sodium Acetate as Carbon Source
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Semin Nephrol.. 2014 May
Role of Circadian Rhythms in Potassium Homeostasis
It has been known for decades that urinary potassium excretion varies with a circadian pattern. In this review, we consider the historical evidence for this phenomenon and present an overview of recent developments in the field. Extensive evidence from the latter part of the last century clearly demonstrates that circadian potassium excretion does not depend… Read Abstract
Semin Nephrol.. 2013 May
Potassium in hypertension and cardiovascular disease.
The increased prevalence of hypertension and cardiovascular disease in industrialized societies undoubtedly is associated with the modern high-sodium/low-potassium diet. Extensive experimental and clinical data strongly link potassium intake to cardiovascular outcome. Most studies suggest that the sodium-to-potassium intake ratio is a better predictor of cardiovascular outcome than either nutrient individually. A high-sodium/low-potassium environment results in… Read Abstract
Phys Chem Chem Phys.. 2018 May
Selective sodium intercalation into sodium nickel-manganese sulfate for dual Na-Li-ion batteries.
Double sodium transition metal sulfates combine in themselves unique intercalation properties with eco-compatible compositions – a specific feature that makes them attractive electrode materials for lithium and sodium ion batteries. Herein, we examine the intercalation properties of novel double sodium nickel-manganese sulfate, Na2Ni1/2Mn1/2(SO4)2, having a large monoclinic unit cell, through electrochemical and ex situ diffraction… Read Abstract
Phys Chem Chem Phys. 2018 Dec
PI3K/Akt signaling pathway and Hsp70 activate in hippocampus of rats with chronic manganese sulfate exposure.
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Nutrition. 1990 Jul
Protein and fat utilization by humans as affected by calcium phosphate, calcium carbonate, and manganese gluconate supplements.
The object of this study was to determine the effect of calcium carbonate or calcium phosphate supplements on dietary protein and fat utilization from low and high manganese diets. During the 63-day study, the 14 human adult subjects ate a constant laboratory controlled diet. In separate periods, subjects consumed the basal diet alone or with… Read Abstract
J Hazard Mater. 2019 Mar
Mineralization of organics in hazardous waste sulfuric acid by natural manganese oxide ore and a combined MnO2/activated carbon treatment to produce qualified manganese sulfate.
To effectively dispose and utilize the hazardous waste H2SO4 generated from alkylation, an environmentally friendly and feasible technology for the simultaneous oxidative degradation of organics and consumption of H2SO4 was developed. Pyrolusite, a natural manganese oxide ore, was used for the oxidative degradation and mineralization of the organics, and reduction leaching of Mn from the… Read Abstract
Genome Res.. 1999 Jun
Improved DNA sequencing accuracy and detection of heterozygous alleles using manganese citrate and different fluorescent dye terminators.
The use of dideoxynucleotide triphosphates labeled with different fluorescent dyes (dye terminators) is the most versatile method for automated DNA sequencing. However, variation in peak heights reduces base-calling accuracy and limits heterozygous allele detection, favoring use of dye-labeled primers for this purpose. We have discovered that the addition of a manganese salt to the PE… Read Abstract
Osteoarthritis Cartilage.. 2001 Jan
Effects of an orally administered mixture of chondroitin sulfate, glucosamine hydrochloride and manganese ascorbate on synovial fluid chondroitin sulfate 3B3 and 7D4 epitope in a canine cruciate ligament transection model of osteoarthritis.
OBJECTIVE: To evaluate effects of an orally administered mixture of chondroitin sulfate, glucosamine hydrochloride and manganese ascorbate (CS-G-M) on articular cartilage metabolism in dogs with cranial cruciate ligament (CCL) deficient and reconstructed knees, as reflected by concentrations of synovial fluid 3B3, 7D4 and total sulfated glycosaminoglycan (GAG). METHODS: Sixteen adult dogs that underwent unilateral CCL transection… Read Abstract
Mil Med. . 1999 Feb
Glucosamine, chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back: a randomized, double-blind, placebo-controlled pilot study.
OBJECTIVE: A 16-week randomized, double-blind, placebo-controlled crossover trial of a combination of glucosamine HCl (1,500 mg/day), chondroitin sulfate (1,200 mg/day), and manganese ascorbate (228 mg/day) in degenerative joint disease (DJD) of the knee or low back was conducted. METHODS: Thirty-four males from the U.S. Navy diving and special warfare community with chronic pain and radiographic DJD of… Read Abstract
Osteoarthritis Cartilage.. 2000 Sep
Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis.
OBJECTIVES: The objective of this study was to evaluate the oral combination of glucosamine HCl, sodium chondroitin sulfate and manganese ascorbate for the treatment of osteoarthritis (OA) of the knee. DESIGN: A randomized placebo-controlled study design was implemented. We recruited 93 patients with OA of the knee from a single center. The intervention group received 1000 mg… Read Abstract
Exp Biol Med (Maywood). 2001 Feb
Effect of pre-loading oral glucosamine HCl/chondroitin sulfate/manganese ascorbate combination on experimental arthritis in rats.
The therapeutic effect of a nutritional supplement consisting of a combination of glucosamine hydrochloride (FCHG49), purified sodium chondroitin sulfate (TRH122), and manganese ascorbate (GCM)3 was investigated in the rat model of collagen-induced autoimmune arthritis (CIA). The GCM compound was mixed with a palatable nutritional paste (Nutri-cal [NC]). Oral administration of the NC/GCM compound was initiated… Read Abstract
Biol Trace Elem Res. 2019 Dec
Dose-Dependent Absorption Profile of Different Magnesium Compounds.
Magnesium, one of the basic elements for the human body, is necessary for many physiological functions. Magnesium deficiency is widely observed as a result of the reduced nutrient content of foods, over-cooking, diseases, drugs, alcohol, and caffeine consumption. Taking a dietary supplement is necessary magnesium deficiency. It has been demonstrated that absorption of organic magnesium… Read Abstract
Biol Trace Elem Res. 2019 Jan
Timeline (Bioavailability) of Magnesium Malate and other Compounds in Hours: Which Magnesium Compound Works Best?
Magnesium is an element of great importance functioning because of its association with many cellular physiological functions. The magnesium content of foods is gradually decreasing due to food processing, and magnesium supplementation for healthy living has become increasingly popular. However, data is very limited on the bioavailability of various magnesium preparations. The aim of this… Read Abstract
J Pharm Biomed Anal. 2015 Jan
Evaluation of enantiomeric purity of magnesium-L-aspartate dihydrate.
Magnesium supplementation in form of organic magnesium salts is a very popular practice. We examined the enantiomeric purity of "Magnesium aspartate dihydrate" monographed in the European Pharmacopeia. A chiral capillary zone electrophoresis using (2-hydroxypropyl)-β-cyclodextrin coupled to laser induced fluorescence detection and a HPLC-fluorescence method with chiral derivatization using o-phthaldialdehyde and N-acetyl-L-cysteine as an orthogonal method… Read Abstract
Dalton Trans. 2019 May
Lipid-Coated, pH-Sensitive Magnesium Phosphate Particles for Intracellular Protein Delivery.
PURPOSE: To develop cationic lipid-coated magnesium phosphate nanoparticles (LPP) for intracellular catalase (CAT) delivery. METHODS: Magnesium phosphate nanoparticles (MgP NP) were prepared by micro-emulsion precipitation and mixed with catalase-loaded cationic liposomes (DOTAP/cholesterol) to yield LPP formulation of catalase (LPP-CAT). The size and ζ-potential of LPP-CAT were measured by dynamic light scattering. The pH-sensitivity of LPP-CAT was determined… Read Abstract
J Biomed Mater Res B Appl Biomater. 2019 Jul
Silver (Ag) doped magnesium phosphate microplatelets as next-generation antibacterial orthopedic biomaterials.
This article reports for the first time our successful result in the synthesis of antibacterial single-phase newberyite (NB, MgHPO4 .3H2 O), an important magnesium phosphate (MgP) bioceramic. The prime novelty lies in the fact that we explore novel MgPs as next-generation orthopedic biomaterials as opposed to conventional calcium phosphates (CaP). While NB has already shown… Read Abstract
Ying Yong Sheng Tai Xue Bao. 2019 Sep
Improvement effects of quicklime and calcium magnesium phosphate fertilizer on acidified soil cultivating Codonopsis tangshen.
To solve the problem of soil acidification in the cultivation of Codonopsis tangshen, laboratory experiments were carried out to investigate C. tangshen seed germination, seedling growth and soil exchangeable acid, microbial community structure after applying quicklime (QL) and calcium magnesium phosphate fertilizer (CMP). The results showed that QL and CMP treatments significantly improved the survival… Read Abstract
Appl Microbiol Biotechnol. 2017 Oct
Biosynthesis of copper carbonate nanoparticles by ureolytic fungi
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Int Dent J. . 2005 Oct
Calcium hydroxide: a review.
Calcium hydroxide is a multipurpose agent, and there have been an increasing number of indications for its use. Some of its indications include direct and indirect pulp capping, apexogenesis, apexification, treatment of; root resorption, iatrogenic root perforations, root fractures, replanted teeth and interappointment intracanal dressing. The purpose of this paper is to review the properties… Read Abstract
Nanoscale. 2019 Apr
A template-free and low temperature method for the synthesis of mesoporous magnesium phosphate with uniform pore structure and high surface area.
Mesoporous phosphates are a group of nanostructured materials with promising applications, particularly in biomedicine and catalysis. However, their controlled synthesis via conventional template-based routes presents a number of challenges and limitations. Here, we show how to synthesize a mesoporous magnesium phosphate with a high surface area and a well-defined pore structure through thermal decomposition of… Read Abstract
Int Endod J. 1991 May
The antimicrobial effect of calcium hydroxide as a short-term intracanal dressing.
The antibacterial effect of calcium hydroxide as a short-term intracanal dressing was clinically evaluated by applying the medicament for 10 minutes or 7 days in root canals of teeth with periapical lesions. The results showed that the 7-day dressing efficiently eliminated bacteria which survived biomechanical instrumentation of the canal, while the 10-minute application was ineffective. Read Abstract
Compend Contin Educ Dent. 1970 Jan
Calcium hydroxide-based root canal sealers: an updated literature review.
Important role in sealing the root canal system with the entombment of remaining microorganisms and filling inaccessible areas of prepared canals. This article reviews sealing ability, biocompatibility, antibacterial activity, solubility, and toxicity of calcium hydroxide based root canal sealers. Read Abstract
Appl Microbiol Biotechnol. 2011 Mar
Effects of nitrogen catabolite repression and di-ammonium phosphate addition during wine fermentation by a commercial strain of S. cerevisiae.
Two deletion mutants expected to be defective in nitrogen catabolite repression (NCR) were constructed in a commercial wine yeast background M2: a ure2 mutant and a dal80 gzf3 double mutant. Wild-type and both mutant strains were fermented in Sauvignon Blanc grape juice with and without addition of di-ammonium phosphate (DAP). The dal80 gzf3 double mutant… Read Abstract
J. Serb. Chem. Soc.. 2010 Jan
Synthesis and characterization of ammonium phosphate fertilizers with boron
The concentration of boron, an essential micronutrient for plants, presents a narrow range between deficiency and toxicity. In order to provide the boron requirement for plants, and to avoid toxicity problems, boron compounds are mixed with basic fertilizers. Sodium borate pentahydrate was used as a boron source. Ammonium orthophosphates fertilizers with boron were prepared by… Read Abstract
Revista Brasileira de Ciência do Solo. 2018 Dec
Acid Ammonium Citrate as P Extractor for Fertilizers of Varying Solubility
There are several globally accepted methods to chemically characterize P-fertilizers, but not all are suitable to predict the agronomic efficiency of the P sources in terms of plant nutrition. Our aim was to investigate the performance of P extractors for fertilizers, investigating the consistency of different methods for P sources of varying properties and the… Read Abstract
Journal of Experimental Botany. 2017 Mar
Ammonium as a signal for physiological and morphological responses in plants
Ammonium is a major inorganic nitrogen source for plants. At low external supplies, ammonium promotes plant growth, while at high external supplies it causes toxicity. Ammonium triggers rapid changes in cytosolic pH, in gene expression, and in post-translational modifications of proteins, leading to apoplastic acidification, co-ordinated ammonium uptake, enhanced ammonium assimilation, altered oxidative and phytohormonal… Read Abstract
Sheng Wu Gong Cheng Xue Bao. 2019 Sep
Acellular vascular scaffolds modified by ammonium phosphate zwitterions can effectively resist thrombosis and promote endothelialization in vitro.
Due to limited availability of autologous blood vessels (blood vessels from the same recipient used for vascular transplantation materials) and inadequate growth ability of non-autologous blood vessels (artificial blood vessel transplantation materials), more and more attention has been paid to tissue engineering blood vessels. In this study, we constructed an ammonium phosphate zwitterion modified acellular… Read Abstract
Calcified Tissue International. 2001 Sep
Mechanisms of action and therapeutic potential of strontium in bone.
The processes of bone resorption and formation are tightly governed by a variety of systemic and local regulatory agents. In addition, minerals and trace elements affect bone formation and resorption through direct or indirect effects on bone cells or bone mineral. Some trace elements closely chemically related to calcium, such as strontium (Sr), have pharmacological… Read Abstract
Journal of Biomedical Materials Research Part A. 2015 Oct
Strontium-impregnated bioabsorbable composite for osteoporotic fracture fixation.
Osteoporosis impairs the bone-healing process as well as bone fracture fixation. The intervention of osteoporosis is considered to be one part of bone fracture treatment. Thus, orthopedic fixators impregnated with antiosteoporosis regimens will improve fracture fixation in osteoporotic bone. In this study, the strontium (Sr) and calcium phosphate ceramic (CPC) were mixed first and then… Read Abstract
Food Chemistry. 2014 Jan
Geographic determination of coffee beans using multi-element analysis and isotope ratios of boron and strontium.
This study aims to evaluate the feasibility of using chemical and isotopic compositions of coffee beans to identify their geographic origins. Twenty-one Coffea arabica beans collected from 14 countries in 3 major coffee-producing regions, Africa, America and Asia, were analysed for multi-element of B, Rb, Sr, Ba, Fe, Mn and Zn, as well as isotopic… Read Abstract
- Poultry Science . 2019 Mar Effects of zinc oxide nanoparticles on growth performance and concentrations of malondialdehyde, zinc in tissues, and corticosterone in broiler chickens under heat stress conditions.
The Journal of Clinical Dentistry. 2014 Jan
The effect of zinc lactate and magnolia bark extract added tablets on volatile sulfur-containing compounds in the oral cavity.
A controlled, clinical, double-blind study was conducted to assess the efficacy of sugar-free tablets containing zinc lactate and magnolia bark extract (MBE) on oral volatile sulfur-containing compounds (VSC) versus placebo tablets for two hours. METHODS: In order to join the study, subjects had to have at least 24 teeth, no report of oral and systemic… Read Abstract
Animal Science Journal. 2015 Aug
Zinc-bearing zeolite clinoptilolite improves tissue zinc accumulation in laying hens by enhancing zinc transporter gene mRNA abundance.
A study was conducted to investigate effects of zinc-bearing zeolite clinoptilolite (ZnCP), as an alternative for zinc sulfate (ZnSO4), on laying performance, tissue Zn accumulation and Zn transporter genes expression in laying hens. Hy-Line Brown laying hens were allocated to three treatments, each of which had six replicates with 15 hens per replicate, receiving basal… Read Abstract
Oral Health and Preventive Dentistry. 2010 Jan
The effects of a zinc citrate dentifrice on bacteria found on oral surfaces.
PURPOSE: Clinical studies with dentifrices formulated with antimicrobial ingredients typically examine the effects of their use on clinical parameters of dental plaque and gingivitis. The effects of routine use of these formulations on the microorganisms found in the distinct regions of the human mouth remain unexplored. The present cross-over design clinical study compared the effects… Read Abstract
Korean Journal of Urology. 2012 Feb
Induction of apoptosis of bladder cancer cells by zinc-citrate compound.
PURPOSE: Zinc is one of the trace minerals in the body and is known to have an anticancer effect by inducing apoptosis in prostate cancer. We aimed to investigate the antiproliferative effects of a zinc-citrate compound in bladder cancer. MATERIALS AND METHODS: A bladder cancer cell line (MBT-2) was treated with a zinc-citrate compound at… Read Abstract
The Journal of Nutrition. 2014 Feb
Zinc absorption by young adults from supplemental zinc citrate is comparable with that from zinc gluconate and higher than from zinc oxide.
The water-soluble zinc salts gluconate, sulfate, and acetate are commonly used as supplements in tablet or syrup form to prevent zinc deficiency and to treat diarrhea in children in combination with oral rehydration. Zinc citrate is an alternative compound with high zinc content, slightly soluble in water, which has better sensory properties in syrups but… Read Abstract
Food and Chemical Toxicology. 2019 Mar
Zinc citrate incorporation with whey protein nanoparticles alleviate the oxidative stress complication and modulate gene expression in the liver of rats.
This study aimed to evaluate the hepatoprotective effect of whey protein nanoparticles (WP-NPs) coated Zinc citrate (Zn) against oxidative stress complications and disturbances in gene expression in rats treated with CCl4. WP-NPs were used to coat Zn at three levels and amino acids content was determined in WP-NPs and the fabrications. Seven groups of male… Read Abstract
Journal of Veterinary Dentistry. 2001 Dec
Clinical and microbiological effects of oral zinc ascorbate gel in cats.
The clinical and microbiological effects of zinc ascorbate gel applied orally in cats were evaluated during a 42-day study period. Cats were divided randomly into two equal groups, with the treatment group (18 cats) receiving zinc ascorbate gel and the control group (18 cats) receiving a placebo (0.9% sterile saline). Clinical parameters evaluated biweekly included… Read Abstract
Clinical, Cosmetic and Investigational Dermatology. 2011 Oct
Susceptibility of Propionibacterium acnes isolated from patients with acne vulgaris to zinc ascorbate and antibiotics.
PURPOSE: The in vitro antimicrobial activity of ascorbic acid derivatives against Propionibacterium acnes was tested either alone or in combination with a variety of antimicrobial agents, and their fractional inhibitory concentration index was determined using checkerboard tests. The antimicrobial effectiveness of zinc ascorbate in the treatment of acne vulgaris, either alone or in combination with… Read Abstract
Clinical, Cosmetic and Investigational Dermatology. 2012 Sep
Zinc ascorbate has superoxide dismutase-like activity and in vitro antimicrobial activity against Staphylococcus aureus and Escherichia coli.
BACKGROUND: Acne vulgaris is a common dermatological disease, and its pathogenesis is multifactorial. OBJECTIVE: We examined whether the ascorbic acid derivative zinc ascorbate has superoxide dismutase (SOD)-like activity. SOD is an enzyme that controls reactive oxygen species production. In addition, the in vitro antimicrobial activity of zinc ascorbate against the Gram-positive bacterium Staphylococcus aureus and… Read Abstract
Contact Dermatitis. 2000 Feb
Strontium nitrate suppresses chemically-induced sensory irritation in humans.
Skin care products are complex formulations that may cause sensory irritation symptoms, characterized by stinging, burning, and itching. Substances capable of counteracting sensory irritation are of great practical interest. Strontium salts have been demonstrated to inhibit sensory irritation and inflammation when applied topically. In this double-blind study, we evaluated the efficacy of strontium nitrate in… Read Abstract
Dermatology. 2010 May
Strontium nitrate decreased histamine-induced itch magnitude and duration in man.
BACKGROUND: Previous studies have demonstrated that strontium salts have a potent and broad ability to suppress sensory irritation. OBJECTIVE: To ascertain the possible antipruritic effects of topical strontium salts, we conducted a double-blind randomized study to evaluate the effect of 20% strontium nitrate on itch magnitude (intensity) and duration. METHODS: In 8 human subjects, strontium… Read Abstract
The American Journal of Clinical Nutrition. 2016 Aug
Bioavailability of potassium from potatoes and potassium gluconate: a randomized dose response trial.
BACKGROUND: The bioavailability of potassium should be considered in setting requirements, but to our knowledge, the bioavailability from individual foods has not been determined. Potatoes provide 19-20% of potassium in the American diet.OBJECTIVE: We compared the bioavailability and dose response of potassium from nonfried white potatoes with skin [targeted at 20, 40, and 60 milliequivalents… Read Abstract
British Journal of Anaesthesia. 2013 May
Effect of intrathecal magnesium in the presence or absence of local anaesthetic with and without lipophilic opioids: a systematic review and meta-analysis.
Spinal anaesthesia is the primary anaesthetic technique for many types of surgery. Adjuncts to the local anaesthetics (LA) used in spinal anaesthesia can exhibit undesirable side-effects, limiting their use, but magnesium may have advantages in this respect. We sought randomized control trials (RCTs) in patients undergoing all types of surgery and in women in labour… Read Abstract
Acta Neurologica Belgica. 2019 Feb
The efficacy of magnesium oxide and sodium valproate in prevention of migraine headache: a randomized, controlled, double-blind, crossover study.
Migraine is a disabling disorder that affects the quality of life of patients. Different medications have been used in prevention of migraine headache. In this study, we evaluated the effectiveness of magnesium oxide in comparison with valproate sodium in preventing migraine headache attacks. This is a single-center, randomized, controlled, crossover trial which is double-blind, 24-week,… Read Abstract
Acta Universitatis Palackianae Olomucensis. 1991 Jan
Osteoporosis treated with magnesium lactate.
33 patients with senile, 18 patients with postmenopausal and 9 patients with medicamentous (corticosteroids) osteoporosis were treated with single therapy of Mg lactate (37 patients) and with the combined one of Mg lactate and Na fluoride (23 patients). They were evaluated in three periods of half a year, one year, two years. The better results… Read Abstract
Nephrology Dialysis Transplantation. 2017 Mar
Magnesium lactate in the treatment of Gitelman syndrome: patient-reported outcomes.
BACKGROUND: Gitelman syndrome (GS) is a rare recessively inherited renal tubulopathy associated with renal potassium (K) and magnesium (Mg) loss. It requires lifelong K and Mg supplementation at high doses that are at best unpalatable and at worst, intolerable. In particular, gastrointestinal side effects often limit full therapeutic usage. METHODS: We report here the analysis… Read Abstract
Drug Development and Industrial Pharmacy. 2018 Sep
The absolute bioavailability and the effect of food on a new magnesium lactate dihydrate extended-release caplet in healthy subjects.
OBJECTIVE: To assess the absolute bioavailability of 20 mEq magnesium lactate extended-release (ER) caplets and to assess the effect of food on the pharmacokinetics of these ER caplets. SIGNIFICANCE: Magnesium in different salt forms is available as over-the-counter oral formulations. The absorption and bioavailability is highly affected by the water solubility of the salt form.… Read Abstract
Acta scientiarum polonorum. Technologia alimentaria.. 2018 Jul
Quality of yogurt fortified with magnesium lactate.
During the tests carried out with rats the organic complex magnesium gluconate was examined for its bioavailability and its stress-reducing properties after oral application. The increase of magnesium concentration in serum achieved by means of magnesium gluconate turned out to be higher than the increase of concentration due to the administration of magnesium chloride. Just… Read Abstract
Zhonghua fu chan ke za zhi. 1997 Oct
Oral low-dose magnesium gluconate preventing pregnancy induced hypertension.
OBJECTIVE: To study the effects of oral low-dose magnesium gluconate in prevention of pregnancy induced hypertension (PIH) and its mechanism. METHODS: A prospective randomized double-blind study was carried out in 51 pregnant women as treatment group (including 22 cases as treatment group 1 and 29 cases as treatment group 2) and 51 pregnant women as… Read Abstract
Journal of Cardiovascular Pharmacology. 2018 Dec
Magnesium Citrate Protects Against Vascular Calcification in an Adenine-induced Chronic Renal Failure Rat Model.
BACKGROUND: Hypomagnesemia was identified as a strong risk factor for cardiovascular disease in patients with chronic renal failure (CRF). However, the effects of magnesium (Mg) on vascular calcification (VC) have not been fully elucidated. Thus, we aim to determine the effects of Mg citrate (MgCit) on VC in CRF rats. METHODS: Rats were divided into… Read Abstract
Journal of Cutaneous Medicine and Surgery. 2018 May
A Case of Hailey-Hailey Disease Managed With Oral Magnesium Citrate and High-Dose Vitamin D3.
Hailey-Hailey disease, or benign familial pemphigus, is a rare blistering disease originally described in 1939. The disease is due to an autosomal dominant mutation in the ATP2C1 gene on chromosome 3, which encodes for an adenosine triphosphate-dependent calcium pump in the Golgi apparatus whose function is to maintain intercellular calcium homeostasis. Common treatments for Hailey-Hailey… Read Abstract
Journal of Nephrology. 2019 Feb
Control of metabolic predisposition to cardiovascular complications of chronic kidney disease by effervescent calcium magnesium citrate: a feasibility study.
AIMS: Cardiovascular (CV) complications are common in chronic kidney disease (CKD). Numerous metabolic disturbances including hyperphosphatemia, high circulating calciprotein particles (CPP), hyperparathyroidism, metabolic acidosis, and magnesium deficiency are associated with, and likely pathogenic for CV complications in CKD. The goal of this feasibility study was to determine whether effervescent calcium magnesium citrate (EffCaMgCit) ameliorates the… Read Abstract
Current Opinion in Clinical Nutrition & Metabolic Care. 2014 May
Meeting iron needs for infants and children
Iron deficiency early in life is associated with impaired neurological development. This study reviews the latest research on how to best meet iron requirements in infants and children. There is concurrent evidence that delayed cord clamping is well tolerated and improves infant iron stores. Iron supplements or enriched complementary foods starting before 6 months of… Read Abstract
Vojnosanit Pregl. 2006 Feb
Resorption and tolerance of the high doses of ferrous sulfate and ferrous gluconate in the patients on peritoneal dialysis.
BACKGROUND/AIM: Iron supplementation plays a crucial role in peritoneal dialysis (PD) patients. Oral iron substitution is more convenient than intravenous therapy in PD patients, but impaired absorption and adverse effects may be limiting factors for oral treatment. The aim of this study was to compare the absorption and side effects of high doses ferrous sulphate… Read Abstract
- Journal of Nutritional Science and Vitaminology. 1991 Apr Improvement in iron deficiency anemia through therapy with ferric ammonium citrate and vitamin C and the effects of aerobic exercise.
Cell Discovery. 2018 Mar
Antiviral effects of ferric ammonium citrate.
Iron is an essential nutrient for cell survival and is crucial for DNA replication, mitochondrial function and erythropoiesis. However, the immunological role of iron in viral infections has not been well defined. Here we found the iron salt ferric ammonium citrate (FAC) inhibited Influenza A virus, HIV virus, Zika virus, and Enterovirus 71 (EV71) infections.… Read Abstract
Send to Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007 Apr
Oral ferric ammonium citrate solution in MRCP for diagnosing low-level obstructive jaundice.
OBJECTIVE: To evaluate the value of oral ferric ammonium citrate solution as a gastrointestinal contrast agent in diagnosing low-level obstructive jaundice. METHODS: Thirty-six patients who were suspected of low-level obstructive jaundice were performed with magnetic resonance cholangiopancreatography (MRCP) and conventional MRI before and after the administration of oral ferric ammonium citrate solution. The diagnostic accuracy… Read Abstract
Acta Radiologica. 1999 Jul
Ferric ammonium citrate as a positive bowel contrast agent for MR imaging of the upper abdomen. Safety and diagnostic efficacy.
PURPOSE: To evaluate the safety and diagnostic efficacy of two different doses of ferric ammonium citrate as a paramagnetic oral contrast agent for MR imaging of the upper abdomen. MATERIAL AND METHODS: Ninety-nine adult patients referred for MR imaging for a known or suspected upper abdominal pathology were included in this randomized multicenter double-blind clinical… Read Abstract
Frontiers in Bioscience. 2004 Sep
Copper storage diseases: Menkes, Wilsons, and cancer
The trace element copper is vital to the healthy functioning of organisms. Copper is used in a multitude of cellular activities including respiration, angiogenesis, and immune responses. Like other metals, copper homeostasis is a tightly regulated process. Copper is transported from dietary intake through the serum and into cells via a variety of transporters. There… Read Abstract
Survey of Ophthalmology. 2013 Nov
Iron, zinc, and copper in retinal physiology and disease.
The essential trace metals iron, zinc, and copper play important roles both in retinal physiology and disease. They are involved in various retinal functions such as phototransduction, the visual cycle, and the process of neurotransmission, being tightly bound to proteins and other molecules to regulate their structure and/or function or as unbound free metal ions.… Read Abstract
Nature. 2014 May
Copper is required for oncogenic BRAF signalling and tumorigenesis.
The BRAF kinase is mutated, typically Val 600→Glu (V600E), to induce an active oncogenic state in a large fraction of melanomas, thyroid cancers, hairy cell leukaemias and, to a smaller extent, a wide spectrum of other cancers. BRAF(V600E) phosphorylates and activates the MEK1 and MEK2 kinases, which in turn phosphorylate and activate the ERK1 and… Read Abstract
Oncotarget. 2016 Jun
Copper as a target for prostate cancer therapeutics: copper-ionophore pharmacology and altering systemic copper distribution.
Copper-ionophores that elevate intracellular bioavailable copper display significant therapeutic utility against prostate cancer cells in vitro and in TRAMP (Transgenic Adenocarcinoma of Mouse Prostate) mice. However, the pharmacological basis for their anticancer activity remains unclear, despite impending clinical trails. Herein we show that intracellular copper levels in prostate cancer, evaluated in vitro and across disease… Read Abstract
Waste Management & Research. 2017 Jun
Optimisation of chemical oxygen demand removal from landfill leachate by sonocatalytic degradation in the presence of cupric oxide nanoparticles.
Leachate is the liquid formed when waste breaks down in the landfill and water filters through that waste. This liquid is very toxic and can pollute the land, ground water, and water resources. In most countries, it is mandatory for landfills to be protected against leachate. In addition to all other harms to the environment,… Read Abstract
Biosensors and Bioelectronics. 2018 Feb
Efficient label-free chemiluminescent immunosensor based on dual functional cupric oxide nanorods as peroxidase mimics.
Dual-functional cupric oxide nanorods (CuONRs) as peroxidase mimics are proposed for the development of a flow-through, label-free chemiluminescent (CL) immunosensor. Forming the basis of this cost-efficient, label-free immunoassay, CuONRs, synthesized using a simple hydrothermal method, were deposited onto epoxy-activated standard glass slides, followed by immobilization of biotinylated capture antibodies through a streptavidin bridge. The CuONRs… Read Abstract
Scientific Reports. 2019 Feb
Electromagnon excitation in cupric oxide measured by Fabry-Pérot enhanced terahertz Mueller matrix ellipsometry.
Here we present the use of Fabry-Pérot enhanced terahertz (THz) Mueller matrix ellipsometry to measure an electromagnon excitation in monoclinic cupric oxide (CuO). As a magnetically induced ferroelectric multiferroic, CuO exhibits coupling between electric and magnetic order. This gives rise to special quasiparticle excitations at THz frequencies called electromagnons. In order to measure the electromagnons… Read Abstract
International Journal of Pharmaceutics. 2007 Jun
Role of copper gluconate/triethanolamine in irinotecan encapsulation inside the liposomes.
A novel method for encapsulating irinotecan into liposomes containing copper gluconate buffered to pH 7.0 with triethanolamine (TEA) has recently been developed. In the present study, the mechanism dictating drug encapsulation and retention inside those liposomes was investigated. Spectroscopic analyses revealed that irinotecan interacted with copper gluconate/TEA in solution. Fourier transformed infrared (FT-IR) spectroscopy indicated… Read Abstract
Bioresource Technology. 2010 Feb
Adsorption of copper-citrate complexes on chitosan: equilibrium modeling.
The effects of complexes on the adsorption of copper from citrate solutions using chitosan were investigated. Various copper to citrate ratios and solution pHs were used to determine the copper adsorption capacity on the chitosan and a mathematical model was developed to simulate the copper adsorption process. According to the model, the three parameters influencing… Read Abstract
Pnas. 2014 Jul
Excited-state structural dynamics of a dual-emission calmodulin-green fluorescent protein sensor for calcium ion imaging
Fluorescent proteins (FPs) have played a pivotal role in bioimaging and advancing biomedicine. The versatile fluorescence from engineered, genetically encodable FP variants greatly enhances cellular imaging capabilities, which are dictated by excited-state structural dynamics of the embedded chromophore inside the protein pocket. Visualization of the molecular choreography of the photoexcited chromophore requires a spectroscopic technique… Read Abstract
Nutrition Reviews. 2012 Jul
Role of calcium during pregnancy: maternal and fetal needs
Although the demand for additional calcium during pregnancy is recognized, the dietary reference intake for calcium was lowered for pregnant women in 1997 to amounts recommended for nonpregnant women (1,000 mg/day), and recently (November 2010) the Institute of Medicine report upheld the 1997 recommendation. It has been frequently reported that women of childbearing age do… Read Abstract
- Journal of Internal Medicine. 2006 May Calcium and vitamin D in the prevention and treatment of osteoporosis – a clinical update
Journal of Biological Chemistry. 2014 Apr
The plasma membrane calcium pump: new ways to look at an old enzyme.
The three-dimensional structure of the PMCA pump has not been solved, but its basic mechanistic properties are known to repeat those of the other Ca(2+) pumps. However, the pump also has unique properties. They concern essentially its numerous regulatory mechanisms, the most important of which is the autoinhibition by its C-terminal tail. Other regulatory mechanisms… Read Abstract
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2019 Mar
Traditional materials from new sources - conflicts in analytical methods for calcium carbonate.
Calcium carbonate (E170) is a common food and pharmaceutical additive/ingredient. In addition to a source of calcium, the carbonate has uses including as a colour, acidity regulator and bulking agent. Globally, a range of regulatory agencies and pharmacopoeia control the analyses and specification of additives in food, supplements, pharmaceutical substances and excipients. Accordingly, a range… Read Abstract
Bioresource Technology. 2013 Sep
High-level production of calcium malate from glucose by Penicillium sclerotiorum K302.
In this study, after screening of 9 fungal strains for their ability to produce calcium malate, it was found that Penicillium sclerotiorum K302 among them could produce high-level of calcium malate. Under the optimal conditions, the titer of calcium malate in the supernatant was 88.6 g/l at flask level. During 10-l fermentation, the titer of… Read Abstract
Journal of Dairy Science. 2019 Jan
Calcium lactate as an attractive compound to partly replace salt in blue-veined cheese.
In addition to their high sodium content, cheeses are thought to induce an acid load to the body, which is associated with deleterious effects on consumers' health. Our objective was to explore the use of alkalinizing salts in partial substitution of NaCl to reduce both the sodium content and the acid-forming potential of cheese, without… Read Abstract
Environmental Toxicology and Pharmacology. 2015 Jan
Anti-inflammatory effects of calcium citrate in RAW 264.7cells via suppression of NF-κB activation.
Here we aimed to investigate the anti-inflammatory effects of calcium citrate in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. The anti-inflammatory effects of calcium citrate were investigated by assessing pro-inflammatory factors (NO, ROS, NF-κB, iNOS, and COX-2) and pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α). Treatment of cells with calcium citrate (10-100μM) significantly reduced the generation of intracellular… Read Abstract
Bioengineered. 2016 Sep
Preparation and properties of calcium citrate nanosheets for bone graft substitute.
A convenient and effective soft chemical method is presented for the synthesis of nano-scaled calcium citrate sheets. The preparation involved the precipitation of nano-calcium citrate by adding ethanol to reach the super saturation state of a solution containing calcium and citrate salts. The obtained nano-calcium citrate formed nanosheets, with the following dimensions: width of about… Read Abstract
Journal of Food and Drug Analysis. 2018 Jan
Codissolution of calcium hydrogenphosphate and sodium hydrogencitrate in water. Spontaneous supersaturation of calcium citrate increasing calcium bioavailability.
The sparingly soluble calcium hydrogenphosphate dihydrate, co-dissolving in water during dissolution of freely soluble sodium hydrogencitrate sesquihydrate as caused by proton transfer from hydrogencitrate to hydrogenphosphate, was found to form homogenous solutions supersaturated by a factor up to 8 in calcium citrate tetrahydrate. A critical hydrogencitrate concentration for formation of homogeneous solutions was found to… Read Abstract
Food Research International. 2018 May
Supersaturation of calcium citrate as a mechanism behind enhanced availability of calcium phosphates by presence of citrate.
Dissolution of amorphous calcium phosphate (ACP) in aqueous citrate at varying pH has been studied with perspective of increasing availability of calcium from sidestreams of whey protein, lactose and/or cheese production or on development of new functional foods. ACP formed as an initial precipitate in 0.10 mol L-1 equimolar aqueous calcium chloride, sodium citrate, and sodium hydrogenphosphate… Read Abstract
Nutrients. 2018 Nov
Chronic Ingestion of Sodium and Potassium Bicarbonate, with Potassium, Magnesium and Calcium Citrate Improves Anaerobic Performance in Elite Soccer Players.
Anaerobic power and anaerobic capacity significantly influence performance in many sport disciplines. These include prolonged sprints in athletics, swimming, or cycling, and other high intensity intermittent sports, such as soccer or basketball. Considering the association of exercise-induced acidosis and fatigue, the ingestion of potential buffering agents such as sodium bicarbonate, has been suggested to attenuate… Read Abstract
Food Research International. 2019 Feb
Calcium citrate insolubilization drives the fouling of falling film evaporators during the concentration of hydrochloric acid whey.
When dairy powders are produced, the mineral fraction undergoes strong modifications during the vacuum concentration step, leading to the fouling of falling film evaporators. The objective of this study was to determine the nature of the deposits formed during the vacuum concentration of two fouling and highly mineralized products: hydrochloric acid whey and lactic acid… Read Abstract
Applied and Environmental Microbiology. 1990 Dec
Mechanism by which ammonium bicarbonate and ammonium sulfate inhibit mycotoxigenic fungi.
In this study we examined the mechanism by which ammonium bicarbonate inhibits mycotoxigenic fungi. Elevated extracellular pH, alone, was not responsible for the antifungal activity. Although conidia of Penicillium griseofulvum and Fusarium graminearum had internal pH (pHi) values as high as 8.0 in buffer at an external pH (pHo) of 9.5, their viability was not… Read Abstract
Chemosphere. 2015 Sep
Combination of powdered activated carbon and powdered zeolite for enhancing ammonium removal in micro-polluted raw water.
Even zeolite is promising in ammonia pollution disposing, its removal efficiency is frequently interfered by organics. As activated carbon has good removal efficiency on organic contaminants, combination of two adsorbents may allow their respective adsorption characteristics into full play. This paper provides a performance assessment of the combination for enhancing ammonium removal in micro-polluted raw… Read Abstract
- Journal of Pharmaceutical Sciences. 2014 Aug Physical characterisation and long-term stability studies on quaternary ammonium palmitoyl glycol chitosan (GCPQ)--a new drug delivery polymer.
Acta Physiologica. 2015 Jun
Ammonium increases Ca(2+) signalling and upregulates expression of Cav1.2 gene in astrocytes in primary cultures and in the in vivo brain.
AIM: The primary aim of this study was to identify the effects of hyperammonaemia on functional expression of Cav1.2 L-type Ca(2+) channels in astroglia.METHODS: Primary cultures of mouse astrocytes were used to study effects of chronic treatment (1-5 days) with ammonium chloride, at 1, 3 and 5 mm on depolarization-induced increases in free cytosolic Ca(2+)… Read Abstract
Journal of Chromatography A. 2016 Dec
Headspace gas chromatography based methodology for the analysis of aromatic substituted quaternary ammonium salts.
The analysis of quaternary ammonium salts (QAS) using GC is often performed by "in injector" pyrolysis to create volatile degradation products for quantification purposes. Besides the risk of severe system contamination, the application of this approach on aqueous samples is problematic. In this work, the sample is treated in a vial with 2,2-dimethoxypropane (DMP) under… Read Abstract
Stem Cells. 2015 Sep
Brief Report: Human Mesenchymal Stem-Like Cells Facilitate Floating Tumorigenic Cell Growth via Glutamine-Ammonium Cycle.
How mesenchymal stem cells (MSCs) promote tumor growth remains incompletely understood. Here, we show that mesenchymal stem-like cells (MSLCs) are commonly present in malignant pleural effusion or ascites of cancer patients, where they directly interact with tumor cells. Chemokines and chemokine receptors, especially the CCL2/CCR2 pathway, are involved in this interaction. As a result, MSLCs… Read Abstract
International Journal of Food Microbiology. 2014 May
New insights into the advantages of ammonium as a winemaking nutrient.
Nitrogen limitation is the most common cause for stuck or sluggish fermentation in winemaking, and it is usually dealt with by supplementing grape juice with either ammonium salts or organic nutrients. These practices have a direct impact on both fermentation kinetics and the sensorial features of the final product. The aim of this work is… Read Abstract
Science of the Total Environment. 2019 Jan
Development of a polydimethylsiloxane-thymol/nitroprusside composite based sensor involving thymol derivatization for ammonium monitoring in water samples.
This report describes a polydimethylsiloxane (PDMS)-thymol/nitroprusside delivery composite sensor for direct monitoring of ammonium in environmental water samples. The sensor is based on a PDMS support that contains the Berthelot's reaction reagents. To prepare the PDMS-thymol/nitroprusside composite discs, thymol and nitroprusside have been encapsulated in the PDMS matrix, forming a reagent release support which significantly… Read Abstract
Proceedings of the National Academy of Sciences of the United States of America . 2014 Jul
Direct observation of electrogenic NH4(+) transport in ammonium transport (Amt) proteins.
Ammonium transport (Amt) proteins form a ubiquitous family of integral membrane proteins that specifically shuttle ammonium across membranes. In prokaryotes, archaea, and plants, Amts are used as environmental NH4(+) scavengers for uptake and assimilation of nitrogen. In the eukaryotic homologs, the Rhesus proteins, NH4(+)/NH3 transport is used instead in acid-base and pH homeostasis in kidney… Read Abstract
Revista Brasileira de Ciência do Solo. 2018 Dec
Acid Ammonium Citrate as P Extractor for Fertilizers of Varying Solubility
There are several globally accepted methods to chemically characterize P-fertilizers, but not all are suitable to predict the agronomic efficiency of the P sources in terms of plant nutrition. Our aim was to investigate the performance of P extractors for fertilizers, investigating the consistency of different methods for P sources of varying properties and the… Read Abstract
Journal of Experimental Botany. 2017 Mar
Ammonium as a signal for physiological and morphological responses in plants
Ammonium is a major inorganic nitrogen source for plants. At low external supplies, ammonium promotes plant growth, while at high external supplies it causes toxicity. Ammonium triggers rapid changes in cytosolic pH, in gene expression, and in post-translational modifications of proteins, leading to apoplastic acidification, co-ordinated ammonium uptake, enhanced ammonium assimilation, altered oxidative and phytohormonal… Read Abstract


text: While the future is unknown and unknowable, bureaucratic agencies such as NASA like to have their agendas set far in advance. This means that we can look forward to a great deal of exciting events in the coming year. Along with the regular suite of expected launches, NASA will be undertaking a number of exciting new missions, likely making some incredible discoveries, and wrestling with potential problems both within the agency and without. Here, Wired takes a look at some of the most important missions and milestones happening in space in 2012. Above: Lunar GRAIL NASA's 2012 got off to an auspicious start when the second of the twin GRAIL satellites successfully entered orbit around the moon during the early hours of the new year. (The first probe entered orbit in the late afternoon of Dec. 31.) Starting in March, the two probes will collect data in order to provide an accurate map of the moon's gravitational field. Such information will give researchers a glimpse of what goes on beneath the lunar surface, allowing them to answer many long-standing mysteries about the moon's origin. One recent theory posits that the Earth once had a second moon that smashed into our current natural satellite. If this is true, the GRAIL satellites will find that the lunar far side has a thicker crust than the facing side. Image: NASADragon Docks With ISS The California-based company SpaceX is scheduled to launch its unmanned Dragon capsule on Feb. 7 to dock with the International Space Station. If successful, it will be the first time a private company has accomplished such a goal, and may be the start of a new era for commercial spaceflight. Dragon will carry supplies for the crew, though nothing crucial just in case the venture fails for some reason. A success would put the company in an excellent position to start offering services to ferry astronauts and future supplies, allowing NASA to stop buying seats on the Russian Soyuz spacecraft. Image: NASAFinancial Angst There will be much anxiety leading up to the release of President Obama's proposed federal budget for the 2013 fiscal year, expected during the 2nd week of February. The budget proposal will suggest how much funding NASA should receive in 2013 and beyond. Over the year, these numbers will be subject to a long and bitter debate process in Congress, which has been looking for ways to slash expenditures in recent years. If 2013 funding is anything like the last couple years, NASA may have to do more and more with less and less. Of high importance will be the details of funding the James Webb Space Telescope, the next generation space-based scientific instrument set to replace the aging Hubble Space Telescope. Already costing far beyond its initial proposed budget, JWST drew the wrath of members of the House of Representatives, who voted to cancel its funding last year. The final version of the 2012 budget bill eventually included funds for JWST, though it came with the stipulation that NASA take the needed money out of other programs. The president's budget proposal might give some clues as to how this allocation will be made. NASA officials are also looking to the 2013 budget before making a final decision on how much they can contribute to future Mars missions. The agency currently has a deal with the European Space Agency to conduct two joint missions to the Red Planet –- one in 2016 and another in 2018 -– though the agency's fiscal problems have made it increasingly unlikely that NASA will be able to honor its commitments. ESA may turn to the Russian space agency to complete both missions, though Russia has had a poor track record thus far with Mars missions. Shortly after the president's budget announcement, NASA is expected to hold Senior Review processes to decide whether or not to continue funding many of its current missions. This may be particularly painful in the agency's Planetary Science division, which is expected to see flat or declining budgets over the next several years. Officials may have to choose between the scientific return on several ongoing missions, including the Cassini spacecraft, Opportunity Mars rover, and Lunar Reconnaissance Orbiter. Image: The James Webb Space Telescope. NASA.Studying Radiation NASA will launch several new missions to better understand radiation and charged particles in the universe. The Nuclear Spectroscopic Telescope Array (NuSTAR) is scheduled for launch on March 16. NuSTAR will scan the night sky for high energy x-rays, building on and seeing at higher ranges than previous x-ray telescopes such as Chandra. It will help astronomers answer many questions about the universe and look for supernova remnants, black holes a billion times the mass of the sun, and subatomic particles accelerated to nearly the speed of light. In August, the agency will launch the Radiation Belt Storm Probes, to study how the sun influences the Earth and its radiation belts. And December will see the launch of the Interface Region Imaging Spectrograph (IRIS), a probe that will look at the solar wind and corona. Image: The NuSTAR telescope in space. NASADiscovery Mission Selection Late in the spring, NASA is expected to make an announcement on future planetary exploration missions for its Discovery class program. These relatively small and low-budget missions have often yielded great scientific insights. Currently, the competition is down to three proposed missions, one of which will be chosen for a potential 2016 launch date. The Geophysical Monitoring Station (GEMS) would drop a seismometer on the Martian surface to study the structure and composition of the planet's interior. Alternatively, the Titan Mare Explorer (TiME) would land a small boat on a lake of Saturn's moon Titan in order to explore the strange processes of an alien sea. Finally, the Comet Hopper would do exactly that: send a satellite to hop on a comet multiple times and study how its surface changes as it approaches the sun. Image: NASA/GSFC/University of MarylandEclipses and Transits The details of celestial mechanics in our own solar system are very predictable and, luckily, not dependent on NASA's budget cycle. The year 2012 will see one important and rare event with the transit of Venus on June 6. While information from the occurrence was once vital for astronomers looking to calculate the distance between the Earth and the sun, it is now merely a spectacular cosmic show for all to enjoy. The moon will appear to partially consume the sun on May 20 during an annular solar eclipse. In this type of eclipse, the moon transits in front of the sun, partially blocking it but leaving a small ring of light around the edge. The event will be seen to viewers placed along a path over the Pacific Ocean from southern China to the Western United States. A total solar eclipse – where the moon will completely block out the sun's light – will occur on November 13, though will mostly occur over open ocean. The only place on land to see it will be parts of Northern Australia. Two partial lunar eclipses will also occur during the year, on June 4 and November 28, respectively. Image: An annular eclipse seen from China in 2010. Wikimedia/A013231MSL Lands The highly anticipated Mars Science Laboratory will undergo a stomach-churning landing maneuver in August to reach the surface of the Red Planet. The largest object that can currently be placed on the Martian surface, MSL is a one-ton rover that will search the planet for signs of water past and present and, more tantalizingly, evidence for native life. The descent will entail a never-before-attempted procedure. The lander will first plummet through the atmosphere before opening a 51-foot parachute to slow down to subsonic speeds. Around 25 feet above the ground, a UFO-like platform will fire rockets and hover above the Martian plains before lowering the rover gently down on a set of wires known as a "sky crane." The hovering platform will then fly far from the rover and crash into the planet's surface. Image: NASA/JPL-CaltechUnknown New Discoveries One thing that can be known with certainty is that the future will be surprising. Over the course of the year, NASA's current suite of missions will continue churning out scientific data, potentially leading to an unexpected discovery. Among the agency's ongoing missions are the following: The Mars-exploring Opportunity rover, still going strong despite the shutdown of its twin on March 22, 2011, will provide important information as it waits out the Martian winter in a favorable spot around Endeavor crater. The planet-hunting Kepler satellite will get ever closer to spotting an Earth-like extrasolar planet, releasing new data in January, July, and October. The Cassini spacecraft, circling the ringed beauty Saturn since 2004, will continue exploring the gas giant and its environ, making a total of 20 flybys around the liquid bearing moon Titan and 10 flybys of the water-spewing Enceladus. The MESSENGER spacecraft, in orbit around Mercury, will continue photographing the planet's polar regions, potentially discovering ice in the deep shadows of craters. And should the agency have the money, the Deep Impact satellite, which shot a projectile at comet Tempel 1 to study its interior and later flew by comet Hartley 2, may make a small course correction in October to set up for an encounter with asteroid 2002 GT in 2020 Image: The smallest extrasolar planets that Kepler has spotted to date. 2012 may see the discovery of smaller and more Earth-like exoplanets. NASA/Ames/JPL-Caltech.Red Space Considering NASA's budget problems and internal squabbles, some in the space industry fear 2012 might be the year China eclipses the United States in space prowess. In 2011, China already performed more orbital launches than the U.S., barely squeaking by with 19 to 18. In addition, the Chinese government released a document outlining their five-year space plan, which includes new launch vehicles, robotic lunar landers, and preliminary studies to land people on the moon. Other analysts counter the idea that the U.S. is sagging in space, pointing out that there is nothing new in China's recently released space plans and that America still leads in human spaceflight. Furthermore, China's space investments are low-budget. But the Chinese government's plan can be carried out with little interruption, whereas NASA's policies are subject to the whims of the White House and Congress, which may change every few years. Image: The Chinese Shenzhou 7 spacecraft launches in 2008. Wikimedia/Gang Lee.End of the World? Despite several doomsayers and predictions arising from the end of the Mayan long count calendar, NASA confirms that the world won't be ending in 2012. Image: Flickr/theilr

subset: commoncrawl


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LPL Financial announced Friday that Michelle Oroschakoff, formerly global risk officer at Morgan Stanley, has been appointed chief risk officer and managing director for the independent broker-dealer.
Oroschakoff, who will be based in San Diego and report to LPL CEO Mark Casady, will be responsible for firmwide risk management processes and controls, including regulatory compliance, data security and privacy and other critical risk management functions, as well as working closely with the firm's regulators.
"We are delighted to welcome Michelle Oroschakoff to our firm," said Casady (left) in a statement. "Her hire is a reflection of the continued importance we attach to risk management, compliance and controls. Michelle's skills in managing risk in a large, complex organization and working closely with regulators will be an important addition to the company."
Casady went on to note that in recent years, LPL's "commitment to strengthening our compliance, risk management and controls culture has intensified, resulting in even greater investments in people, processes and infrastructure. Michelle's hire is part of our significant investment in multiple enhancements to our risk management structure."
Oroschakoff joins LPL from Morgan Stanley, where she was most recently the global chief risk officer of the wealth management division and prior to that, chief compliance officer for Morgan Stanley Smith Barney.
Before serving in these roles, she was the general counsel for Fisher Investments, an independent RIA. Earlier, she spent 11 years in a number of senior legal and compliance roles at Morgan Stanley, including as associate general counsel and head of the firm's San Francisco litigation department.
Oroschakoff noted in the same statement that she was "excited to be joining LPL Financial during this time in the firm's history. I look forward to working closely with Mark and the rest of the executive team to continue to enhance the firm's compliance infrastructure, policies and systems. Having a robust compliance, risk management and controls function will help ensure that growth is well-managed and sustainable."
Check out 12 Best & Worst Broker-Dealers: Q1 Earnings, 2013 on AdvisorOne.


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Mike Gray brauchte ein neues Logo Design und hat einen Wettbewerb auf 99designs gestartet.
Aus 55 Designs von 13 Designern wurde eine Gewinner gewählt.
Life in the Rough has grown a lot and I'm looking to give the site a more professional feel as I begin networking and expanding deeper into the world of golf blogging. I'm looking for a logo/header image to complement a re-design effort that I recently started.
Life in the Rough
Life in the Rough is a golf blog where I share my passion for the game. The primary goal is to become a golf pro and share my experiences and things that I learn on the way. The secondary goal is to share tips and information to help others play better and enjoy the game more.
I'd like a header/logo that I can build the new design around.
As you can see from looking at the current blog design at http://www.lifeintherough.com, I used a free Wordpress theme and have since replaced the original header image with something that I cobbled together that appears amateurish and is a sore spot for me. My plan is to redesign the site with a wider layout and a smaller header, with some other differences. You can see what I have in mind here: http://www.lifeintherough.com/testbed. The color scheme is still up in the air, but you can see the location and size that I have in mind for the header. However, that is flexible as well.
There are two ways that I'd like to go with the design. Feel free to explore either path.
- One way I'd go is with something clean, professional, and modern. Something simple, but not to the point of being dull.
- The other way I've been thinking about going is something with more of an antique feeling. The best I can describe that mindset is to imagine for a moment an old country club sitting room with lots of dark mahogany and leather and old photographs of the legends of the game lining the walls. The background pattern on the current site kind of fits in with that theme and may be something that I try to reuse. Something that makes me think of Bobby Jones and Ben Hogan and great players of the past and the long, rich history of golf. If this path is explored, a simple logo may not convey the same feeling, so something more intricate or ornate may be more fitting, but in general, simple is better.Feel free to explore different color schemes, but conservative colors are preferable.
- Either a modern, clean feel, or an antique, historic feel
- Something simple, but not dull
- A somewhat conservative feel (not loud colors, etc.).
- Something that demonstrates my passion for golf (if that's even possible)
- A logo that gives Life in the Rough a distinct identity
- A logo with a lighthearted feel is OK (after all, Life in the Rough is a somewhat mildly self-deprecating title), but nothing cartoonish
- A logo that is versatile and could be used on business cards or golf shirts
- I'd like my passion for the game and its history to shine through.
- No loud colors
- Nothing cartoonish
- The blog title lends itself to the presence of grass (rough), but I'd like it to be played down some. Grass isn't discouraged, but it should be somewhat subtle, and definitely isn't required.
Finden Sie heraus, wie ein Designwettbewerb funktioniert, oder lernen Sie mehr über unsere Logo-Design-Angebote.


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Despite a new coach and several new players, Toronto FC proved an old adage true: The more things change the more they stay the same. And that will likely mean more personnel changes in the coming days.
Based on Toronto's 2-0 loss to the Columbus Crew on Saturday in both teams' season opener, that's an understatement. The loss prolonged Toronto's winless streak against Columbus, but coach Preki was still optimistic about his team's play.
"It's a good step for us even though the result didn't go for us," Preki told MLSsoccer.com. "There're 29 games to go. It's a long season. We'll discuss a couple of things in the locker room and we'll be okay. This is a good team we played and a team that has a lot of good players. They won the Supporters' Shield last season."
But many of the issues that plagued Toronto last season resurfaced again in the season opener for both teams at sunny Crew Stadium. The Reds were outplayed for most of the match with Columbus controlling most of the possession in the midfield, especially in the first half.
With the departure of steadying force Carl Robinson, leadership in the midfield will rest with Canadian international Julian de Guzman. While de Guzman has been a stalwart for Canada in the middle, earning CONCACAF Gold Cup all-star honors, he and his teammates looked ordinary against a more organized Crew attack.
Columbus looked like a team that had played together a long time and it showed with its ability to hold the ball and find penetrating passes.
Toronto's defense had trouble with Columbus's pesky forwards, particularly Guillermo Barros Schelotto. They conceded numerous corner kicks and on a few occasions coughed up the ball in its own end.
"The first 30 minutes the game was in the middle of the field and then we got some confidence," said Crew coach Robert Warzycha. "We created some other opportunities. We need to work on the last pass, obviously. Running on the ball and off the ball and creating chances we had plenty today. We also had 10 corner kicks and they had one."
The pressure ultimately led to the first goal when defender Jim Brennan was called for a foul near the sideline. On the ensuing free kick, Andy Iro outjumped Brennan to head Schelotto's hard cross just inside the left post by a helpless Stefan Frei.
Give full marks to Iro and Schelotto, who later added an insurance marker in the 87th minute to put the game out of reach.
"It was a weird game. I don't think the result was fair at all," said Preki. "Having to deal with a few corners and set pieces and one of them we fall asleep.
After 45 minutes, Columbus didn't create any opportunities in the first half and we go into halftime 1-0 down. (Crew goalkeeper) Will (Hesmer) makes a couple of good saves. If he doesn't, obviously, we win the game. He made the difference for them."
The silver linings for Toronto were their chances in the second half and the play of striker O'Brien White, who was active and almost scored the equalizer. As promised, Preki implemented a 4-4-2 formation practiced throughout training camp with Dwayne DeRosario and White up front.
But despite their combined talents, the same song played with the midfield failing to provide proper service. Then the same refrain from last year kicked in with De Rosario trying to single-handedly lead the team back late in the game.
When Schelotto got the insurance goal in controversial fashion, the same sad song came to an end.
To be fair, it will take time for the players to adjust to new teammates and Preki's system. But despite Preki's optimism, what's of great concern based on this showing, is the team's inability to score, just like last season.
This game marked the fourth straight goalless outing going back to the three exhibition matches in the Carolina Challenge Cup.
Interestingly, Preki said in training that he's more concerned about defense than scoring. Defense wins games, of course, but that's based on the premise that a team would score its own share of goals.
Offense generates in the midfield and with a middle dominated by defensive midfielders, goals may be hard to come by even if the club can acquire a top class striker.