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Bioscience investigators in Ohio are accessing vast amounts of genetic, clinical, imaging and environmental data to individualize the diagnosis and treatment of disease. For instance, oncology researchers are developing computational techniques to enhance the diagnosis of follicular lymphoma. A biomolecular engineer is generating complex computer simulations to better understand how misfolded proteins contribute to Alzheimer's disease. And, a pediatric hospital is leveraging advanced computational and storage resources to analyze data generated by their next-generation DNA sequencing machine. In addition to health care, the application of bioscience to energy, industrial products and agriculture is growing in importance. More than 1,250 bioscience-related organizations in Ohio employ over 55,000 highly-skilled workers, according to BioOhio, a nonprofit industry association. The following pages illustrate just a few examples of cutting-edge research in the biosciences supported by the powerful computational resources of the Ohio Supercomputer Center.
- Designing computer-aided analysis for Lymphoma
- Modeling retrotransposons' role in cancer
- Simulating misfolded proteins in Alzheimer's
- Discovering drugs for cancer therapies
- Implementing DNA sequencing technology
- Creating new genomic sequence predictions
- Applying high-end X-rays to cancer treatment
- Calculating disparity in RNA polyadenylation


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For Immediate Release, October 18, 2012
Contact: Emily Jeffers, (415) 779-4253 or firstname.lastname@example.com
EPA Urged to Overturn Standards That Allow Corrosive Seawater
Legal Petition Seeks Stricter Rules to Prevent Ocean Acidification, Save Marine Wildlife
SAN FRANCISCO— The Center for Biological Diversity filed a legal petition today urging that the Environmental Protection Agency override water-quality standards for 15 coastal states and territories because those standards are too lax to protect wildlife from the harmful effects of ocean acidification. The Clean Water Act requires that all states have standards for ocean pH (acidity), and many states are not meeting the EPA's recommendation needed to protect aquatic life.
"Imagine visiting Hawaii and seeing the coral reefs crumble away before your eyes. Well, right now that's what Hawaii would allow, without even recognizing there was a water-quality problem," said Emily Jeffers, an oceans attorney at the Center.
As the petition demonstrates, there are many states whose water-quality standards are inadequate to protect marine life from being exposed to corrosive waters. Carbon dioxide pollution from factories, cars and power plants causes ocean acidification, which impairs the ability of shellfish, corals and other animals to build the skeletons and shells they need to survive. The EPA's water-quality criterion recommends that seawater acidity should not change more than 60 percent (0.2 pH units) as a result of anthropogenic causes; but under many states' current standards, the acidity of ocean waters would be allowed increase hundredfold — become 100 times higher — without any action being taken to address the problem.
"The Clean Water Act turns 40 today, and it's time that it grows up and takes on one of the toughest and meanest water-quality crises in America's history — water pollution caused by fossil fuels," Jeffers said. "Some 22 million tons of carbon dioxide pollution are dumped on our oceans every day. If we don't act soon, that's going to have massive, irreversible effects on marine life and the oceans that we love and rely on."
The states and territories whose water quality standards don't go far enough to protect sea life from ocean acidification are Alabama, Connecticut, Delaware, Guam, Hawaii, Louisiana, Maine, Maryland, Mississippi, North Carolina, Northern Mariana Islands, Oregon, Puerto Rico and Virginia.
Bringing state water-quality standards up to par will ensure that waters that are in trouble from ocean acidification are identified and managed to protect fish, shellfish and other marine animals; this in turn will help protect the people and economies that depend on ocean resources.
In response to a lawsuit brought by the Center in 2009, the EPA affirmed that states must assess and identify marine waters that are impaired by ocean acidification under the Clean Water Act.
The Center for Biological Diversity is a national, nonprofit conservation organization with more than 450,000 members and online activists dedicated to the protection of endangered species and wild places.
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subset: commoncrawl


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A VIRUS is going round called Housework. If you feel the need to start housework - Stop Immediately!!
This virus affects your sleep and wipes out your social life.
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If you should come in contact with housework
go straight to the nearest store and get
the only known antidote which is called......
Please forward this warning immediately to a least 6 friends. If you realize you do not have 6 friends, you are already infected


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text:
Laws, Regulations & Annotations
Business Taxes Law Guide – Revision 2019
Cigarette and Tobacco Products Tax Law
Section 30479
30479. Penalty; retailer convicted twice. If any retailer, as defined in Part 1 (commencing with Section 6001) of this division, is convicted under any provision of this part and has any previous conviction within a 10-year period under this part, the State Board of Equalization shall revoke all permits issued to such person under the Sales and Use Tax Law for a period of one year.
History.—Added by Stats. 1968, p. 2251, in effect November 13, 1968.


text: Found in the warm waters of the Indian and Pacific Oceans, the peacock mantis shrimp is arguably one of the most captivating creatures in the sea. Its hard-shelled body is bursting with color—hues of bright red, green, orange and blue, and its forearms are covered in spots. At the top of its head rests a set of protruding eyes, and they aren't just for show. These crustaceans have the most complex eyes in the animal kingdom, containing millions of light-sensitive cells. With 16 color-receptive cones (compared to humans, who have just three), the peacock mantis shrimp can detect ten times more color than a human, including ultraviolet light. It can move each eye independently and uses this exceptional eyesight to avoid predators and track down prey. The peacock mantis shrimp lives in the crevices of coral and rocks on the ocean floor. A territorial creature, it has been known to exhibit aggressive behavior toward intruders. This ferocious shrimp has club-like appendages that fold beneath its body, resembling a praying mantis. With a spring-like motion, it uses these appendages to attack prey—and a mantis shrimp's punch is no joke. With the ability to strike at the speed of a .22 caliber bullet (50 times faster than the blink of an eye), a blow from a mantis shrimp can easily break through the shell of a crab or mollusk. Mantis Shrimp Infographic Click for full infographic Its lineage can be traced back five hundred million years. It is multicolored with shades of bright green, orange, red and blue on its shell and forearms covered in spots. There are 400 species of mantis shrimp worldwide. A peacock mantis shrimp can punch with a speed equal to a .22 caliber bullet. It is able to see ten times more color than human beings, including ultraviolet light. Did You Know? This crustacean can punch with a speed equal to a bullet Diet The peacock mantis shrimp can kill prey larger than itself by using its deadly appendages. It typically feeds on gastropods, crabs and mollusks. Size Mantis shrimp typically grow to lengths of two to seven inches. Range This species is found in the warm waters of the Indian and Pacific Oceans. Population Status This species is not threatened. Predators Some large fish make a meal of the mantis shrimp. Back to the Top


text: The best for its size 5 I use this product daily, the best part is there is a plenty of room for all my stuff. The cover on this bag is magnetic which is awesome, unlike other that has a tearing noise while you open them.Its easy to carry both in hands and shoulders no matter how much my stuff weighs inside. I never ran out of space for my devices and gadgets which i carry around in it. faiz Dubai, United Arab Emirates 2015-11-13


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IT support in Watford and surrounding
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You might not rock wings 365 days a year, but who doesn't want bronzed skin and voluminous tresses? In honor of the brand's runway show in New York tonight, we caught up with Alessandra Ambrosio to get all the details on an angel's pre-show beauty routine. We also asked about what she uses at home to get angel-like bedhead and what's earned a permanent place in her makeup bag. You may have to wait until December 10th to see the show, but you can check out all of her must-haves right now.
Ambrosio doesn't hesitate when asked for her pre-show beauty secret: "I use Joanna Vargas' Exfoliating Mask ($75): you rub it in like a scrub, but leave it on like a mask," she says. The model follows the mask with her normal routine of Clarins' Toning Lotion With Camomille ($22) and Joanna Vargas' Daily Hydrating Cream ($75). "It's my pre-show beauty secret."
A Victoria's Secret angel has a very specific look—bronzed skin, big hair, and nude lips—and it's one that Ambrosio's adopted in real life. The products that get here there? M.A.C.'s Bronzing Powder ($25), Oribe's Dry Texture Spray ($39), and her must-have lip color: Victoria's Secret Lipstick ($12) in Whisper. "I think a nude lip is very sexy."
"Sometimes I'll just apply lip balm over a nude lip liner," she says.
On days off, the mother of two keeps it simple, applying Cle de Peau's Concealer ($70) and RMS Beauty's Lip2Cheek ($36) in Promise. "I just blend a little bit of the Lip2Cheek onto my lips and cheeks for everyday. It's the perfect creamy pink color.
Ambrosio stays loyal to her go-to mascara and eyeliner: Benefit's They're Real! Mascara ($23) and YSL Long-Wear Waterproof Eye Pencil ($30), both of which she likes for their quick and easy application. "This mascara sticks to every single lash!" she says.
"Victoria's Secret has this great brush with sparkles that we use before shows," Ambrosio says about the brand's Instant Bronzing Shimmer Powder ($24). "It gives this really nice shimmer that's perfect for the runway."
"I love the new Chloe perfume," Ambrosio says of Chloe's Roses de Chloe Eau de Toilette Spray ($120).
"My daughter always steals these out of my bag," Ambrosio says of EOS' Organic Lip Balm Spheres ($3). "My favorites are the fruit and the mint flavors," she says.
"I prefer to play up my eyes on the red carpet," Ambrosio says.
"This shadow feels creamy, but turns into a powder," Ambrosio says about Chanel's Long Wear Luminous Eyeshadow ($36). "I wear the gold shade the most, but I also like the taupe and the black." Try the shades Initiantion, Mirifique, and Convoitise.


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Members in good standing at Club Nintendo got a heads up from Nintendo of America today, as "Elite Status" rewards for 2009 will be arriving soon. Specifically, Club Nintendo is "preparing to begin shipping" said rewards.
That means you should keep an eye out for the Mario hat or Animal Crossing calendar that you may have opted for this year, lest your neighbor steal your mail and coveted Nintendo-themed trinket. Club Nintendo cautions "even though your friends or neighbors may receive their Reward before you do, please be assured that your order is being processed too!" So be patient.
We've not heard of anyone receiving their Club Nintendo goods yet, but we're sure we will soon enough. Thanks to everyone from the tips line for the heads up! (Even though I got my notification too!)


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If you'd like to create your own stickers for WhatsApp, you can package them in an Android or iOS app. You can publish your sticker app like any other app to the Google Play Store or Apple App Store, and users who download and install your app will be able to start sending those stickers right away from within WhatsApp. Stickers on WhatsApp must be legal, authorized and acceptable. Learn more about acceptable uses of our services from our Terms of Service.
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text:
Categories > Celebrities > Fall Out Boy
Hugs Are Overrated Just FYI0 reviews
-Sighs- This is a dream I had that was a little strange but fun so I just had to continue it. And since there is no Jonas Brothers category. I added fall out boy into this mix.
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The Scottish Book
|Alphabetical list of History Topics
|History Topics Index
What follows is the preface to a typed document entitled "The Scottish Book" sent by Stan Ulam from Los Alamos to Professor Copson in Edinburgh on January 28 1958.
The enclosed collection of mathematical problems has its origin in a notebook which was started in Lwow, in Poland in 1935. If I remember correctly, it was S Banach who suggested keeping track of some of the problems occupying the group of mathematicians there The mathematical life was very intense in Lwow Some of us met practically every day, informally in small groups, at all times of the day to discuss problems of common interest, communicating to each other the latest work and results. Apart from the more official meetings of the local sections of the Mathematical Society (which took place Saturday evenings, almost every week!), there were frequent informal discussions mostly held in one of the coffee houses located near the University building - one of them a coffee house named "Roma" and the other "The Scottish Coffee House". This explains the name of the collection. A large notebook was purchased by Banach and deposited with the headwaiter of the Scottish Coffee House, who, upon demand, would bring it out of some secure hiding place, leave it at the table, and after the guests departed, return it to its secret location.
You can see more about the Scottish Café at THIS LINK.
Many of the problems date from years before 1935. They were discussed a great deal among the persons whose names are included in the text, and then gradually inscribed into the "book" in ink. Most of the questions proposed were supposed to have had considerable attention devoted to them before an "official" inclusion into the "book" was considered. As the reader will see, this general rule could not guarantee against an occasional question to which the answer was quite simple or even trivial.
In several instances, the problems were solved, right on the spot or within a short time, and the answers were inscribed, perhaps some time after the first formulation of the problem under question.
As most readers will realize, the city of Lwow, and with it the "Scottish Book", was fated to have a very stormy history within a few years of the book's inception A few weeks after the outbreak of World War II, the city was occupied by the Russians. From items at the end of this collection, it will be seen that some Russian mathematicians must have visited the town; they left several problems (and prizes for their solutions). The last date figuring in the book is May 31, 1941. Item Number 193 contains a rather cryptic set of numerical results, signed by Steinhaus, dealing with the distribution of the number of matches in a box! After the start of war between Germany and Russia, the city was occupied by German troops that same summer and the inscriptions ceased.
The fate of the Scottish Book during the remaining years of war is not known to me. According to Steinhaus, this document was brought back to the city of Wroclaw by Banach's son, now a physician in Poland. (Many of the surviving mathematicians from Lwow continue their work in Wroclaw. The tradition of the Scottish Book continues. Since 1945, new problems have been formulated and inscribed and a new volume is in progress.)
A general word of explanation may be here in order: I left Poland late in 1935 but, before the war, visited Lwow every summer in 1936, '37, '38, and '39. The last visit was during the summer preceding the outbreak of World War II, and I remember just a few days before I left Poland, around August 15, the conversation with Mazur on the likelihood of war. It seems that in general people were expecting another crisis like that of Munich in the preceding year, but were not prepared for the imminent world war. Mazur, in a discussion concerning such possibilities, suddenly said to me " A world war may break out. What shall we do with the Scottish Book and our joint unpublished papers? You are leaving for the United States shortly -- and presumably will be safe. In case of a bombardment of the city, I shall put all the manuscripts and the Scottish Book into a case which I shall bury in the ground". We even decided upon a location of this secret hiding place; it was to be near the goal post of a football field outside the city. It is not known to me whether anything of the sort really happened. Apparently, the manuscript of the Scottish Book survived in good enough shape to have a typewritten copy made, which Professor Steinhaus sent to me last year.
The existence of such a collection of problems was mentioned on several occasions, during the last 20 years, to mathematical friends in this country. I have received, since, many requests for copies of this document. It was in answer to such oral and written requests that the present translation was made. This spring in an article, "Can We Grow Geniuses in Science?" which appears in Harper's June, 1957 issue, L. L. Whyte alluded to the existence of the Scottish Book. Apparently, the diffusion of this small mystery became somewhat widespread, and this provided another incentive for this translation.
Before deciding to make such an informal distribution, I consulted my teacher and friend (and senior member of the group of authors of the problems), Professor Steinhaus, about the propriety of circulating this collection. With his agreement, I have translated the original text (the original is mostly in Polish) in order to make it available through this private communication.
Even as an author or co-author of some of the problems, I have felt that the only practical and proper thing to do was to translate them verbatim. No explanations or reformulations of the problems have been made.
Many of the problems have since found their solution, some in the form of published papers. (I know of some of my own problems, solutions to which were published in periodicals, among them, e.g. Problem 17, l. Z. Zahorski, Fund. Math. 34 183-245 and Problem 77(a), R. H. Fox, Fund. Math. 34 278-287.)
The work of following the literature in the several fields with which the problems deal would have been prohibitive for me. The time necessary for supplying the definitions or explanations of terms, all very well understood among mathematicians in Lwow, but perhaps not in current use now, would also be considerable. Some of the authors of the problems are no longer living and since one could not treat uniformly all the material, I have decided to make no changes whatsoever.
Perhaps some of the problems will still present an actual interest to mathematicians. At least the collection gives some picture of the interests of a compact mathematical group, an illustration of the mode of their work and thought; and reflects informal features of life in a very vital mathematical centre. I should be grateful if the recipients of this collection were willing to point out errors, supply information about solution to problems, or indicate developments contained in recent literature in topics connected with the subjects discussed in the problems.
It is with great pleasure that I express thanks to Miss Marie Odell for help in editing the manuscript and to Dr. Milton Wing for looking over the translated manuscript .
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Tomorrow on Wednesday, October 24th – The Ego Co will be opening up a small little event called The Costume Ball. It's an intimate affair with a few friends and oh so intricate designs. One of the designers is Izzie's who is showcasing her lovely newest skin Fuyu in a special Costume Ball Edition. The paleness of the look works wonderfully well with the ethereal darkness of GizzA's creation Fiers de la Haute for this month's FAIR . The Costume Ball will be from October 24th through November 1st – See you there!
Dress: GizzA – Fiers de la Haute – Black / Giz Seron *FAIR October*
Earrings: Donna Flora – Folia Earrings / Donna Flora *Cinema 2012*
Skin: Izzie's – Fuyu Skin – Costume Ball Edition – MB CL / Izzie Button *The Costume Ball – October 24th*
Shape: My own
Hair: ::Exile:: Sober – Raven / Kavar Cleanslate
Eyes: .ID. STR / Mesh Eyes / The Woods / Green / Audrey Lamede
Freckles: Izzie's – Elena Freckles Natural (body & face) / Izzie Button
Eyeliner: Izzie's – Elena Eyeliner / Izzie Button
Eyeliner: MiaMai's – Diamonds 03 / Monica Outlander *Lazy Sunday*
Eyelashes: Maitreya Mesh Eyelashes / Onyx LeShelle
Nails: Izzie's – French Nails / Izzie Button
Pose: Posie's / Anatalia Honi


text:
Porw Translation Team - Russian
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The latest issue of the 9th Scroll is here! You can read all about it in the news.


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Life @ Doane
Doane is a great place to live on the way to the degree and job you've always wanted. In fact, more than 75 percent of students live on campus.
Four residence halls are available for first-year and transfer students with great amenities like air conditioning, Wi-Fi, free laundry and kitchen facilities. What makes them different? Their dorm vibe.
Renovations in 2009 brought much needed A/C, a tiered theatre, Wii, pool table, ping pong, foosball and bbq patio. What didn't change– the relaxed, homey atmosphere where you can make friends easily.
A soothing, zen appeal greets you in this hall. However, this calm interior is full of dynamic, fun spaces – music studio, TV lounge, large back patio with fireplace and lawn chess, and much more.
The #1 thing residents want you to check out: THE coolest basement gaming room with Wii, Xbox 360, Playstation 3 and two large screen TVs. Renovated in 2011, the hall is sleek and modern with a loungy feel.
It's full name is Hansen Leadership Hall– as in be prepared to hone your skills and get involved! This hall is known for its perfect mix of quiet for studying and ease of finding friends when study time is over.
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text:
A blessed Lent to all!
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Well they're certainly something akin to dinosaurs... or at least something that's not around any longer. I don't find it a stretch to affirm some of the creationist theories for these being dinosaurs (oral traditions; dinosaur eggs on the ark; etc.).
I like the Jordanville translation of the Psalter - with Psalm 103 using Dragon. Nice and poetic an easy to chant.
If anything I have posted has been illuminating, please remember that I merely reflect the light of others...but also it's me.
The problem with them being "dinosaurs" (as we think of them) is that the Scriptures seem to talk about these strange fellows in the present (and even future) tense (Job 41;Ps. 74:14; 104:26; Is. 27:1). That said, I still don't have a problem with them them being something akin to dinosaurs: it is for example interesting that the Scriptures and Fathers connect Leviathan with something akin to a dragon or sea monster, while the word dinosaur really means "Monstrous Lizard" or something like that; there seems to be a good bit of leeway in how we understand this creature (though it does seem to be an amphibian and not a reptile). It could be any of them in part, or all of them put together in some form or fashion, IMO. More importantly, I think, is the more "spiritual" side of what we should make of Leviathan. "For, behold, the Lord cometh out of his place to punish the inhabitants o fthe earth for their iniquity: the earth also shall disclose her blood, and shall no more cover her slain. In that day the Lord with his sore and great and strong sword shall punish leviathan the piercing serpent, even leviathan that crooked serpent; and he shall slay the dragon that is in the sea." (Is. 26:21-27:1) It is interesting to compare this with Rev. 20.
But to read a (religious) poem as a chronicle of fact is to say the least, to miss the point. To say a little more, it is to prove oneself a dolt, and to add to this, the men who put these (Holy) books together were not dolts but knew precisely what they were doing.."
That's what Tiamat is about:
It's shouldn't be taken to literally mean Jesus hates the sea and will stomp it out, but He will overcome chaos, or disorder, disunity, etc. John doesn't mean that literally there will be no water, but no more chaos.
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text: http://www.canon.com/news/2010/mar16e.html Canon Inc. announced today that it will begin the acquisition process for > the top-level domain name ".canon," based on the new generic Top Level > Domain (gTLD) registration system. > The non-profit organization ICANN (Internet Corporation for Assigned Names > and Numbers), which maintains and regulates the Internet's addressing > system, has rigorously evaluated the current gTLD string of characters' > societal value, utilization purpose, and use in an organization's > operations. At its International Public Meeting held in June 2008, however, > ICANN approved the relaxation and liberalization of the new gTLD system > adoption rules. Following this meeting, a number of disputes arose > surrounding whether the entry procedures were fair and adequate, and it was > expected that the new gTLD system would commence registration application > within 2010 at the earliest. The new gTLD system is expected to allow a > company name, brand name, geographic region, or service type to be used as a > gTLD within website and e-mail addresses. > Along with its expanding global business activities, Canon will continue to > provide online information and services to its users, consumers, and other > stakeholders, across the world's countries and regions. With the adoption of > the new gTLD system, which enables the direct utilization of the Canon > brand, Canon hopes to globally integrate open communication policies that > are intuitive and easier to remember compared with existing domain names > such as "canon.com." Canon has made the official decision to begin > necessary procedures to acquire ".canon" upon the introduction of the new > system. Following approval for the new gTLD system, which is expected to > take place after the latter half of 2011, Canon will make full use of the > new domain name to increase the convenience and effectiveness of its online > communications. Info on the new program here: http://www.icann.org/en/topics/new-gtlds/program-en.htm Seems like a logical extension. The no-individuals policy seems a little strange, especially since this will inevitably lead to the rise of businesses who will operate registries for you. And it seems like a gamble for most companies, at least in the short-term, since .canon will probably have the same sketch factor as canon.biz and the like. Plus, what's their main domain going to be? canon.canon? www.canon? Maybe useful for conglomerates, though, or companies with a lot of products warranting individual sites: coke.coke, sprite.coke, etc. -- Jebadiah Moore http://jebdm.net


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The finance department at Matthews Motors Clayton is here to make the used car loan process a hassle-free experience. With our convenient online credit application, local drivers from here in Clayton, NC as well as nearby Raleigh or Garner can get pre-qualified for used car loans as they shop for a pre-owned vehicle.
If you are shopping the pristine used cars for sale from Matthews Motors Clayton, then don't hesitate to also send us a financing application so that we can get to work securing a competitive loan package for your upcoming vehicle purchase. Our dedicated used car dealership offers financing assistance for all, so we welcome drivers with healthy credit, no credit and credit challenged situations to apply for auto loans today.
We refresh our inventory multiple times throughout the day. Please visit us again soon and try searching again. You may also contact us and let us know what vehicle you are searching for and we can look for you.
Do you have questions or comments for us? We'd love to hear them! Fill out the form and we will get back to you as soon as possible.
If you need help with any aspect of the buying process, please don't hesitate to ask us. Our customer service representatives will be happy to assist you in any way. Whether through email, phone or in person, we're here to help you get the customer service you deserve.


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IDENTIFICATION OF SMALL-MOLECULES TARGETING CXCR2 FUNCTION AND SIGNALING by Helen Nen Ha A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (PHARMACEUTICAL SCIENCES) August 2013 Copyright 2013 Helen Nen Ha
Object Description
|Identification of small-molecules targeting CXCR2 function and signaling
|Ha, Helen Nen
|Author email
|Doctor of Philosophy
|Document type
|Degree program
|Pharmaceutical Sciences
|School of Pharmacy
|Date defended/completed
|Date submitted
|Date approved
|Restricted until
|Date published
|Advisor (committee chair)
|Neamati, Nouri
|Advisor (committee member)
Okamoto, Curtis Toshio
Duncan, Roger
Beringer, Paul
|Chemokine receptor, CXCR2, and its ligands are an essential component of the immune system that mediates the trafficking of neutrophils to sites of infection. It is also important in angiogenesis by activating and coordinating the assembly of endothelial cells. Given its roles in the immune system and angiogenesis, CXCR2 has been implicated in a number of inflammation-mediated diseases such as chronic obstructive pulmonary diseases (COPD) and various types of cancer. CXCR2 inhibition has shown promising anti-inflammatory effects in the clinics as well as anti-cancer effects in several in vivo animal models. And within the last two decades, several classes of small-molecules targeting CXCR2 has been developed and advanced onto clinical trials. ❧ However, current CXCR2 inhibitors are limited to four major chemical classes of compounds and are by far scarce compared to other clinically relevant therapeutic targets. Thus, we sought to identify additional classes of CXCR2 inhibitors using cell-based, functional assays rather than conventional competitive ligand binding assays. We also capitalized on the literature of previously described CXCR2 inhibitors and developed a pharmacophore model to identify important chemical features of CXCR2 inhibitors and to perform in silico screening of large databases of compounds. ❧ We have identified several classes of compounds that modulate CXCR2 signaling and cellular functions in CXCR2-expressing cells. These compounds are chemically different from any reported CXCR2 inhibitors. Mechanistic studies of these compounds showed that they differentially regulate CXCR2-mediated G-protein and β-arrestin1/2 signaling. For example, CX4338 inhibited CXCR2-mediated β-arrestin1/2 recruitment, while enhancing CXCR2-mediated G-protein signaling (calcium and ERK1/2 activation). Selective inhibition of CXCR2/β-arrestin1/2 association by CX4338 was sufficient to reduce cell migration and LPS-induced PMN migration. We also discovered CX797 in our screening endeavors using a cell-based cyclic AMP assay. CX797 inhibited the effects of CXCL8 on forskolin-induced cyclic AMP signaling, while enhancing CXCR2/β-arrestin2 association and up-regulating total CXCR2 expression. CX797 also inhibited CXCL8-mediated cell migration and cell proliferation in CXCR2-expressing cell lines. ❧ Lastly, using a pharmacophore model, we identified CX25 as a potent inhibitor of CXCR2 in the Tango assay. However, these class of compounds did not show much selectivity amongst different chemokine receptors and inhibited cancer cell proliferation in a CXCR2-independent manner. CX4152 was also identified from the pharmacophore screen and exhibit similar chemical features as CX25. Though CX4152 was not as active as CX25 against CXCR2, it showed 8-fold selectivity for CXCR2 over CXCR4 (another chemokine receptor). Mechanistic studies suggest that CX4152 inhibit CXCR2/β-arrestin-2 association via CXCR2 down-regulation. Treatment with CX4152 reduced surface CXCR2 expression within 10 minutes in a dose and time dependent manner. Taken together, compounds identified from our screens have differential effects on CXCR2 signaling and provide several novel avenues to mechanistically modulate CXCR2 function and signaling.
|CXCR2; CXCL8; inflammation
|Format (imt)
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|University of Southern California dissertations and theses
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|University of Southern California
|Place of publication (of the original version)
|Los Angeles, California
|Publisher (of the digital version)
|University of Southern California. Libraries
|Electronically uploaded by the author
|Legacy record ID
|Contributing entity
|University of Southern California
|Ha, Helen Nen
|Physical access
|The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the author, as the original true and official version of the work, but does not grant the reader permission to use the work if the desired use is covered by copyright. It is the author, as rights holder, who must provide use permission if such use is covered by copyright. The original signature page accompanying the original submission of the work to the USC Libraries is retained by the USC Libraries and a copy of it may be obtained by authorized requesters contacting the repository e-mail address given.
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|University of Southern California Digital Library
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|USC Digital Library, University of Southern California, University Park Campus MC 7002, 106 University Village, Los Angeles, California 90089-7002, USA
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|IDENTIFICATION OF SMALL-MOLECULES TARGETING CXCR2 FUNCTION AND SIGNALING by Helen Nen Ha A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (PHARMACEUTICAL SCIENCES) August 2013 Copyright 2013 Helen Nen Ha


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The NHL's GM meetings wrapped up this week, and lost in the foofaraw over hits to the head was the Islanders' brilliant idea to render the six months of the regular season meaningless.
Charles Wang, who we remind you must still pay Rick DiPietro for the next 11+ seasons, sent GM Garth Snow to the meetings with a revolutionary new plan for the playoffs. The teams finishing eighth through fifteenth in the conference would play a single elimination tournament for the final playoff sport. It'd be like the Elite Eight, only with the eight worst teams. (So it's like the CBI.)
Let's get this straight. The Oilers, by far the worst team in the league, would merely need to win three games in a row in this "play-in" mini-tourney to make the playoffs.
Forget the logistical problems of staging 14 games around the continent on short notice. Wang claims it would generate interest in those fanbases currently without playoff hopes. Maybe so, but it would demolish the interest anywhere else. At this time of year, the only drama is among those teams on the bubble. Once the seventh seed is locked up, there would be no incentive for any team to go for that eighth spot.
One theory is that the system worked in the Olympics, so Wang wants to import some of that unpredictability. My own theory is that winning three in a row is a lot more plausible for the Islanders than rebuilding a contender any time soon.
A play-in for the playoffs [Globe And Mail]


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Declaration of Conformity
Declaration of Conformity with the German Corporate Governance Code
On 24 February 2020, the Management Board and Supervisory Board issued the following Declaration of Conformity in accordance with Section 161 of the Stock Corporation Act (Aktiengesetz – AktG):
Since the last Declaration of Conformity issued on 22 February 2019, SIMONA AG (hereinafter referred to as "SIMONA") has complied and continues to comply with the recommendations of the Government Commission of the German Corporate Governance Code in the applicable version of 7 February 2017, with the exception of the following departures:
Section 3.8 paragraph 3 – D&O insurance deductible for Supervisory Board
Explanation: The Supervisory Board discharges the duties incumbent upon it with the utmost sense of responsibility. A deductible in respect of D&O insurance would represent no improvement and would provide no additional incentive.
Section 4.2.3 paragraph 4 sentences 1 and 3 – Severance pay cap
Explanation: The current Management Board contracts include no provisions for capping in respect of payments made to a Management Board member on premature termination of his/her contract. The Supervisory Board deems as inappropriate the use of such a severance pay cap.
Section 4.2.5 paragraph 3 – Itemised presentation of Management Board compensation
Explanation: On 10 June 2016, the Annual General Meeting of Shareholders of SIMONA agreed by the requisite majority of three-quarters to disclose Management Board compensation in an aggregated format, divided into fixed and performance-related components, rather than disclosing each amount by name. Therefore, no itemised presentation for each Management Board member, detailing specific compensation parameters and using the recommended model tables, shall be provided by the company. This resolution applies to the financial years 2016 - 2020.
Section 5.3.3 – Nomination Committee within Supervisory Board
Explanation: The Board plans to form a Nomination Committee in view of the upcoming elections of shareholder representatives to the Supervisory Board in 2021.
Section 5.4.1 paragraphs 2 and 3 – Diversity concept regarding composition of Supervisory Board and regular limit regarding term of office
Explanation: The Supervisory Board supports the fundamental importance of diversity to the company with regard to its composition. However, contrary to the recommendations set out in Section 5.4.1 of the Code, the Supervisory Board has decided against specifying concrete objectives in the form of quotas or absolute figures. As regards its nominations submitted to the General Meeting, the Supervisory Board primarily takes into consideration the individual abilities, knowledge and professional experience of male and female candidates. With this in mind, no regular limit with regard to length of membership for members of the Supervisory Board has been defined. The Supervisory Board is of the opinion that, in particular, the expertise of experienced Supervisory Board members with a proven track record spanning many years and a demonstrable understanding of the industry and enterprise should be made available to the company.
Section 5.4.6 paragraph 1 sentence 2 – Remuneration for Chair of Supervisory Board committees
Explanation: The Articles of Association of SIMONA include provisions outlining special compensation in respect of the role of chairperson and deputy chairperson of the Supervisory Board. Additionally, membership of Supervisory Board committees is subject to special compensation. By contrast, no separate compensation is payable in respect of the chairmanship of a committee, and such a policy is not deemed necessary at present.
Section 7.1.2 sentence 4, first half sentence – Publication deadline for consolidated financial statements
Explanation: SIMONA publishes its consolidated financial statements in compliance with statutory schedules of disclosure. Owing to the procedures defined for the preparation of financial statements, the aim being to deliver the greatest possible transparency and accuracy, earlier publication would not be feasible.
Kirn, 24 February 2020
Supervisory Board and Management Board
This is a translation from German into English. Only the German document shall be considered authoritative.


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University of Nebraska Board of Regents to make campus visit to UNK 2013
The University of Nebraska Board of Regents will make a campus visit to the University of Nebraska at Kearney on Friday, Feb. 15, 2013. The Board will hear presentations on academic initiatives and campus growth, tour parts of campus, and hear from students, among other activities.
All meetings will take place in UNK's Ockinga Seminar Center, 2505 20th Ave.
The full itinerary for Friday's campus visit is as follows.
8:15 a.m. Chancellor's welcome and overview
8:30 a.m. Mobile Learning
9 a.m. Featured Academic Program – Supply Chain Management
Presenters: Steve Schulz, assistant professor of marketing and management information systems, and Tom Henning, president and CEO of Cash-wa Distributing Co.
9:30 a.m. Walking Tour (Health Science Education Complex/South Campus development sites)10 a.m.Health Science Education Complex/Pre-Professional Programs
Presenters: Charles Bicak, senior vice chancellor for academic and student affairs, and Peggy Abels, director of health programs and the Kearney Health Opportunities Program
11 a.m. South Campus Development
Presenters: Barbara Johnson, vice chancellor for business and finance, and Douglas Bisson, vice president and community planning manager for HDR Engineering Inc.
11:45 a.m. Foundation Progress
Presenter: Peter Kotsiopulos, vice president and UNK campus director of development for the University of Nebraska Foundation and executive director of the UNK Alumni Association
Noon: Lunch
12:15 p.m. Student Interactions/Perspectives
Presenters: Justin Vogel, Scottsbluff; Colleen Kellar, Rapid City, S.D.; and Whitney Nelson, Hastings
1 p.m Break
1:10 p.m. Department of Justice Violence Against Women Grant
Presenters: LeAnn Obrecht, director of counseling and health care, and Trish Holen, assistant director of the Women's Center
1:30 p.m. UNK Central to Nebraska – Impact Data & Wrap-up
Presenter: Chancellor Doug Kristensen
Melissa Lee
Director of Communications,
University of Nebraska


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We found 2 items that match your search.
PSC/CUNY Executive Council Resolution on the Proposed Elimination of Hostos Community College
In 1976, the Executive Council of the Professional Staff Congress (PSC) produced this resolution to convey their opposition to the proposal to close multiple community college campuses in New York City's effort to save money. They also resolved [...]
Item Type: Text (Resolution / Legislation)
Subjects: 1970s Fiscal Crisis, Activism, Austerity, Board of Higher Education, Community Colleges, CUNY Administration, Labor Unions, Relationships with Communities, State and/or City budget
Eco De Hostos, Edición Especial, Hostos Community College, Diciembre 1974
Eco de Hostos was a bilingual student newspaper published monthly by the Office of College Relations and Development. This December 1974 issue (Spanish language edition) features an article about students, faculty and the PSC protesting against [...]
Item Type: Text (Newspaper / Magazine / Journal)
Subjects: 1970s Fiscal Crisis, Activism, Austerity, Bilingual Education, Board of Higher Education, Community Colleges, Labor Unions, Student Organizations


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iSTOCK/GETTY IMAGES
Better tape restores
Don't find out the hard way that your tape-based backup system isn't working as planned. Here are some best practices that will increase the odds that your restores will work.
- Jeff Harbert
- John Merryman, GlassHouse Technologies, Inc.
|iSCSI inspires low-cost storage networks
Backup applications vary considerably in their implementation, performance and management. Here are some tuning factors to consider for leading backup applications:
Fragment size. Some applications like NetBackup let you specify backup fragment size. For instance, a fragment size of 2GB means a 100GB backup will be broken into 50 separate fragments when written to tape. When restoring data, rather than scanning the entire 100GB, NetBackup forwards the tape to the specific fragment containing the requested data, resulting in faster restores.
--Jeff Harbert
Often, full TSM client restores take forever because the client data is spread across too many tape volumes. As dozens, or hundreds, of volumes are mounted for a restore, critical restore time is lost due to tape mounts, dismounts, mount wait settings and data seek time sinks. The key to successfully leveraging tape for restore in a TSM environment boils down to application policies and data classification. Streaming high-volume/large-file client data directly to tape maximizes tape drive performance in most environments. The same holds true for data restores from tape. TSM application policies also play an integral role in optimizing tape performance. TSM policies that directly affect tape restore performance include collocation, maximum number of mount points and resource utilization.
Collocation is a storage pool configuration parameter that can be configured to collocate data by client, by group of clients (available in v. 5.2 only) or by file space. Collocation by client means that a particular client's backup data is stored on tapes only for that client. This reduces the number of mount points required for a large restore and lowers the restore time. The downside: lower tape utilization requires more library space, and space reclamation processing can become time-consuming with a greater distribution of client data across physical volumes.
A handful of server and client settings also dramatically affect the amount of data TSM can move to and from tape for a given client. Increasing the client's maximum number of tape drive mount points and also increasing the client's resource utilization setting allows a client to run multiple data sessions to or from multiple tape devices.
For critical clients, many TSM users also run the occasional selective (full) backup to further reduce the number of mounts required for restores. Other critical considerations include network infrastructure settings and policy so that your network doesn't become the bottleneck once you optimize the application's tape use.
--John Merryman
Pools. Most backup applications allow data classification data based on various dependencies such as data type, backup start time, etc. Within Legato NetWorker, pools are used to distinguish what data is sent to specific volume sets. By default, NetWorker sends all data to one pool. Once a volume is assigned to a pool, only data that meets the specific criteria will be written to that volume. Most users split data based on data type, retention period or for off-site purposes when cloning is not in use. Pools should be used with caution. They provide a great way to separate mission-critical data, but can make NetWorker more difficult to administer.
Dedicated Storage Nodes. NetWorker provides the option to dedicate tape drives to specific clients, thereby upgrading them to storage nodes. The client will need to directly attach--via a SCSI or a storage area network (SAN) connection--to the library/tape drives. There are two ways to license a storage node. First, a full storage node license can be purchased, which allows backing up all local data directly to tape, as well as the ability to send other client data to the library/tape drives directly attached to the storage node. The second option is a dedicated storage node license, which doesn't allow other client machines to send their data to the storage node. The dedicated storage node license is considerably less expensive than a full storage node license, making it a wise investment when performing backups of large servers. Users also can implement dynamic drive sharing (via a SAN) to allow any system attached to the SAN to upgrade to dedicated storage nodes and to share multiple tape drives for backup and restore. The data is not multiplexed between clients--only one storage node can allocate the tape drive at a given time--allowing faster client restores.
Cloning and staging. All enterprise backup software creates duplicate copies of data. Cloning, with an off-site media rotation schedule, ensures that copies of data are available in a disaster-recovery situation, as well as retaining an onsite data set for recovery. Cloning in NetWorker demultiplexes the data, thereby creating contiguous savesets on the cloned volume. In restore situations, using the clone volume allows NetWorker to spend less time forwarding throughout the tape and more time restoring the data. Users with large amounts of disk available also can stage data to disk first (which is also demultiplexed) and then clone the same demultiplexed data to tape later. In NetWorker v. 7, using the advanced file type device option allows simultaneous read/write, which can greatly speed up the cloning process.
--Natalie Mead, with Nate Kosta
Exacerbating the tape restore problem is that few companies proactively monitor, report and remediate issues within their tape-based backup environments. This requires a great deal of effort and manpower, and an understanding of the tape infrastructure. In many cases, time is the limiting factor, leaving risky restores as an unavoidable consequence. In order to minimize the chances of an unsuccessful or time-consuming restore, it's essential that you prepare by optimizing your backup infrastructure for recovering data. This involves developing best practices for the backup infrastructure and refining overall operational approaches.
Best practices for better restores
Critical factors that are related to restore performance include backup application configuration, network configuration, media management and the client environment during a restore. The following guidelines will help increase the likelihood of successful file restores.
It's important to reduce disk drive contention for restored data. During restores, you should disable applications that may be accessing the same disks to which the data is being restored. Also, you should disable packet-reading software as well. Then there's virus-protection software, which when set to its highest protection level, scans every incoming and newly created file. During a restore, the recovered files appear as new files which would be scanned, thereby significantly slowing down the restore.
Some clients have too much data to back up over the network within an allocated backup window. For those hosts, backing up to dedicated tape drives can reduce the amount of time required to back up and recover data. Also, when possible, tune the network buffer size of the client's network card to match the tape drive buffer. This ensures that the recovered packets do not overrun or underfill the buffers. It also will help to modify the data transfer buffer sizes to match the tape drives. If data is sent in packets that are too small, the drives will end up spinning cycles waiting for data, and there will be empty space between data blocks on the tape. The further data is spread out on the tape, the longer it will take to restore.
You should also make sure you match the throughput of the host bus adapter to the drive throughput. If you attach 10 LTO-2 drives (30MB/sec each, for a total of 300MB/sec) to one 1Gb/sec host bus adapter (a theoretical maximum of 128MB/sec), data won't stream to the drives during backup. The sporadic nature of the data transfer will spread the data blocks across the tape, requiring even more time to restore the data.
It's also important for you to regularly expire your media. While the type of media you use does not typically affect restore times, the condition of the media does. As media experiences more and more read/write passes, the integrity of the media begins to break down, which can cause media errors. It's possible that data will be written to tape successfully, but then won't be readable because of the media's degradation. You should also be sure to clean your drives, too. If the backup fails because of dirty tape drives, all the preparation in the world won't help you.
This next tip may sound obvious, but you should make certain that the drive is available. The throughput of new tape drives often exceeds the total throughput of the data sent to the drives (slower networks or too few host bus adapters are typical causes). The result may be that the 10 new LTO-2 drives you just purchased actually run slower than the DLT7000 drives they replaced. There are several ways you can remedy this problem, but most of them involve making additional expenditures. These include things like upgrading the network infrastructure or replacing the backup server with a higher end system.
There is an alternative way to create a balanced tape, network and backup server infrastructure, which is to reduce the total number of drives being used during a backup. Not only will this improve backup performance, it also will leave some drives free for restores in the case they are needed. If a restore request is received during the backup window, and all the drives are actively backing up data, either the restore isn't performed until the backups finish, or active backup jobs are killed to handle the restore request.
If the data is critical to your business operations (and therefore, has a short recovery time objective), you should consider implementing additional solutions, such as snapshot or raw-disk backups, to improve backup and recovery performance. Either of these processes may incur additional expenditures, but if the data really is truly mission-critical, it becomes easier to justify the cost of going beyond traditional tape backup.
|Data and backup device mapping matrix
Operational issues
Backup and restore times can be greatly affected by the number and size of the files you are backing up. Millions of small files pose a serious challenge for traditional tape backup products. When written to tape using typical backup products, a large number of small files can significantly impair the performance of even the fastest drives. It's not uncommon to see backup and restore speeds of 50KB/sec to 100KB/sec on tape drives rated to run at 15MB/sec to 30MB/sec. This dramatically increases backup and restore times and at the same time decreases the lifespan of the tape drives and media.
If you are aware of the fact that these kinds of small data files exist in your environment it will help in your preparations for successfully recovering your data. If you want to make the best use of your primary disk and tape backup destinations, a good first step is to classify data based on its characteristics (file size and file volume) and volatility because it affects incremental or cumulative incremental data movement. As a rule, disk subsystems provide optimal performance for large numbers of small files, while tape works best for small numbers of large files. The reason for this boils down to random vs. sequential access to data on the respective device types.
Classifying backup clients into groups based on data characteristics creates a logical basis for segregating backup workloads among different types of target storage devices (see "Data and backup device mapping matrix").
Creating a general matrix for mapping client types to device types is one practical way for backup administrators to optimize utilization of tape devices for backup and restore operations, in cases when disk is already part of the picture. Because every backup environment is unique in terms of its data and its hardware and software infrastructure, coming up with an ideal backup data classification system requires extensive planning, measurement and adjustment along the way.
|Common causes for tape failures
Problem management
Tape devices are among the most active devices in the data center and, as such, are very prone to different types mechanical problems. The majority of mechanical failures occur during startup or shutdown cycles, as opposed to steady-state operational failures. In a large tape library environment, thousands of start/stop actions occur daily among the library robotics, drives and tape media elements. Inevitably, things will go wrong (see "Common causes for tape failures"). However, the disastrous consequences of a failed restore can be avoided if you actively practice proper systems management. Properly managing tape infrastructure issues and controlling associated risks is key to this.
Too often, organizations don't realize that they will have a problem restoring data until it's already too late. "Too late" usually means that the data has been lost and now must be recovered from tape. Regular, random testing of your restore procedures can help you avoid this eleventh-hour problem. Restore testing will help you identify potential bottlenecks, problem clients/data sets or breakdowns in your process. Identifying these obstacles prior to actually needing the data gives you sufficient time for tuning your environment and to prepare for the inevitable restore request. By simply integrating restore testing into the application delivery process, you gain preproduction exposure for potential recovery pitfalls. As data volumes grow, ongoing recovery testing should be given equal weight as performing software upgrade tests in any mission-critical application environment.
Prepare for disk
Over the next several years, it's quite possible that disk-based backup could potentially displace tape as the primary backup media. Until then, it is extremely critical to make sure that your current tape infrastructure continues to support all of your recovery needs. Restores are not just about technology: Overall operational procedures are also essential to successful backup and restore operations.
Rapidly introducing disk to replace a poorly managed tape infrastructure is a bad idea because it may very well exacerbate existing issues in your environment, at a high cost and at a great risk to your organization. Inadequate management or weak operational practices are often the root cause of the instability of tape infrastructures. As inadequate practices are rolled into a disk technology base, the underlying management problems will manifest themselves not only as restore failures, but they may also affect your entire backup infrastructure, seriously threatening the integrity of your data.
Dig Deeper on Tape backup and tape libraries
Modernizing the 3-2-1 backup strategy for SMB customers
Drug research firm mulls tape, picks integrated data backup appliance
Cloud data backup is not cloud disaster recoveryBy: Biff Myre
Backup best practices: Easy fixes for your enterprise backup systemBy: W. Preston


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Note:Only domain managers and domain administrators can perform this procedure.
Use the following procedure to create a context:
Click the Contexts tab to reveal the Contexts page.
Click the New Context icon.
Complete the New Context wizard, noting the following:
The new context must be based on a context template. Available context templates are shown in the Template drop-down list. Only context templates set as active are listed. Domain administrators can create new context templates and make existing ones active using the Context Templates tab (see Section 4, "Working with Context Templates").
The description will be viewable, for example, when creating other Oracle IRM components that are dependent on this one, so a brief but informative description will prove useful.
You should normally make the context visible to inspectors. This serves two main purposes: to enable domain administrators (who should also be set up as inspectors) to see all contexts, and therefore to predict the effect of changes they make to context templates; and to provide read-only access to help inspectors answer support queries.
The Managers page is used to create one or more context managers for the new context (although the user creating the context is automatically assigned as a context manager). Context managers assign roles to users and are usually business owners.
For global enterprises, use the Translations page to create multi-language descriptions of the context that will be visible to users of Oracle IRM Desktop. If the New Translation icon is not available, translations have not been set up on the Control Console. See Section 1.3.2, "Oracle Enterprise Manager Fusion Middleware Control Console".
Use the Review page to review all the attributes that will be assigned to the new context. If there are any attributes that you want to change, use the Back button to return to previous pages and make the required changes.
When you are satisfied with the attributes on the Review page, create the new context by clicking Finish.
The new context appears on the left panel of the Contexts page. The attributes of the context (rights, managers, translations, roles, trusted contexts) are shown on the right panel.


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Trade Winds captures the spirit of new discovery, and historic trade. Modern designs in vivid colors mix with ancient visual flavors to create a rich and timeless collection
Tradewinds by Lily Ashbury for Moda Fabrics
| Home | About | Contact | Links | Shipping | Privacy |
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Tradewinds - Macaw Blue
Tradewinds - Moroccan Red
| Display All Items on This Page in Detailed View | Change Store Display to Detailed View |
Questions? Email us at firstname.lastname@example.com


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Babylon Pro 10.5.0.11.Retail Multilingual + Content
Babylon Pro 10.5.0.11 Retail Multilingual + Content | 27.0/663.4 MB / 2.2 GB
Babylon 10 is the world's leading dictionary and language translation software. Babylon offers you the most intuitive tool for all your translation needs. With Babylon you can quickly translate emails, web pages, documents, instant messages, and more.
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text:
Oxy Shock
|Potassium Peroxomonosulphate
|An alternative shock-treatment based on oxygen release that doesn't release chlorine smells. It is mainly used on Spas on a weekly basis to give a boost
of oxidising agent to kill off any bacteria that might be present.
|Pool Shock Dose
|Add 500g per 10,000 gallons of pool water in 100g quantities at a time.
|Chlorine/Bromine Spas
|Shock weekly with Oxy Shock. Add 30g per 1,000 litres of water.
|Oxy Shock treated Spas
|Add 30g daily per 1,000 litres of water. Bathers can return after 30 minutes. Shock dose weekly by adding 100g per 1,000 litres of water.
|Whirlpool Baths
|Add 25g directly into the bath water after bathing. Run the pump for 5-6 minutes then drain to waste. For irregularly used baths add
100g before bathing and run pump for 10 minutes, drain and refill to bathe.
|Dosing Method
|Fill a clean plastic container with warm water and add the required amount of Oxy Shock to the container. Stir well with a clean stirrer and then distribute evenly.
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5 Items
Oxy Shock - 20kg£129.99
Oxy Shock - 10kg£74.99
Oxy Shock - 5kg£39.99
Oxy Shock - 2kg£18.99
Oxy Shock - 1kg£11.99
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5 Items


text:
Letter to the Senate Urging Support for the Tax Extenders Bill
September 18, 2008
Dear Senator:
On behalf of the National Education Association's (NEA) 3.2 million members, we urge you to support the tax extenders bill (H.R. 6049), scheduled for possible floor debate this week. This bill includes important provisions that would extend the Secure Rural Schools and Community Self-Determination Act, the tax deduction for educators' out-of-pocket classroom supply expenses, the Qualified Zone Academy Bonds (QZAB) school modernization program, and the Child Tax Credit. These issues are critically important to children and public education. NEA members across the country will be watching congressional actions closely.
- The Secure Rural Schools and Community Self-Determination program is essential to the survivability of over 800 rural counties and 4,400 schools near national forests in 42 states across the country. It has made a real difference for schools in rural, timber-dependent counties, by ensuring them a consistent funding stream. Since its creation in 2000, the program has been an enormous success. Prior to implementation of this program, schools in forest counties were in crisis, experiencing dramatic reductions in funding. The program has restored critical educational services for students in rural schools and prevented the closure of numerous isolated rural schools.
Unfortunately, the program has expired. Failure to reauthorize and fund it immediately will result in a substantial and devastating funding cut for rural counties across the country. Congress has only a short time to act before counties have to start implementing cuts to schools and services. In fact, a number of counties around the country have already sent out pink slips notifying employees of potential layoffs.
- The educator tax deduction helps recognize the financial sacrifices made by teachers and paraprofessionals. Studies show that educators spend more of their own funds each year to supply their classrooms, including purchasing essential items such as pencils, glue, scissors, and facial tissues. For example, NEA's 2003 report Status of the American Public School Teacher, 2000-2001 found that teachers spent an average of $443 a year on classroom supplies. More recently, the National School Supply and Equipment Association found that in 2005-2006, educators spent out of their own pockets an average of $826.00 for supplies and an additional $926 for instructional materials, for a total of $1,752.
- The QZAB program has proven to be an efficient and cost-effective way to help disadvantaged communities address pressing renovation and repair needs. QZABs assist school districts in rural and urban communities by providing a financing mechanism to renovate buildings and invest in equipment and technology. Investors receive a federal tax credit equal to the amount of interest payable on the bonds, thereby relieving local taxpayers and municipalities of the interest burden.
- The Child Tax Credit provisions would extend the credit to working families who don't earn enough to qualify for the current credit. Many of these are young families, struggling to balance child care and work and who are scraping together a living, while trying simultaneously to make time for their young children.
Again, we urge your support for this important legislation.
Thank you.


text:
Skilled Nursing
St. Joseph's Home is located in Kenosha, Wisconsin just minutes from Lake Michigan.
Our facility boasts 13 acres of park like settings that are clean and quiet. Along with a 24 hour skilled care nursing home, we offer apartments for seniors.
Our main visiting area is very comfortable and offers a Home like atmosphere for visits with loved ones outside their rooms. It is located just off the main reception desk.
The grounds has a chapel that offers daily mass and a chaplain in residence. The chapel is open to residents and visitors alike and offers a quiet area for reflection and prayer.
The facility offers a number of sitting areas through-out and all offer a view of the landscaped grounds. Outdoor picnic areas are available when weather permits. A large screen TV area , Activities room, Full service Dining area and other amenities make for comfortable living.
The Activities Department offers a large number of programs and outings for our residents.
Our skilled staff is available for many needs including physical, occupational and speech therapy. Many programs are available for the well being of our residents and guests. Our resident dogs live in the building and provide pet therapy. An enclosed song bird display is located just off the dining area.


text:
iOS 6 Predictions
|March 6th, 2012
|Spencer Nielsen
It is always fun to try and guess what Apple is going to do next. You can guarantee that there will always be surprises and sure bets, letdowns and magical moments. The Apple rumor sites do a decent job of soliciting leaks, reading between the lines and making educated conjecture. As a developer, I often like to take a good look at where Apple's technology is right now and make logical extrapolations as to where things are headed. Oftentimes, when Apple announces some new feature or technology it seems obvious in retrospect if we had only connected the dots. Based on 2011's release schedule, it is a fair bet to say that Apple is going to announce iOS 6 at WWDC sometime this summer and distribute a developer beta. That means that in the coming months little trickles of information are going to get doled out to the rumor sites about what kind of changes and additions we can expect. Just for fun, I wanted to get my own predictions out in the open before any of that started. Here is my very developer-oriented prediction list of what we might be expecting in iOS 6.
UPDATE: WWDC and the iOS 6 beta have come and gone. Some of my predictions now have conclusions. You will notice however that most of the predictions have not yet been updated. That is because there is the potential for Apple to be keeping a few more surprises up their sleeve for the fall when iOS 6 goes GM. Inline below are the results so far.
UPDATE2: iOS 6 GM is here which means that the NDA has lifted! Check down below to see how well I did. (more…)