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The Healthcare Technology Revolution
PDFelement posted a blog entry in PDFelement BlogTechnology has undoubtedly touched every aspect of human life and revolutionized many sectors. The Healthcare sector is no different, and technology has the power to transform it into a highly evolved experience for both patients and medical professionals. But many healthcare practices are stuck in the old way of doing things. Through the use of digital tools, like PDFelement for example, and other digital systems, Healthcare could be greatly improved. Here are just a few of the ways that technology could revolutionize healthcare: 1. More Accessible Data Easy accessibility of data from mega servers is the hallmark of today's advancing technology. Instant and detailed information is available in the blink of an eye and enables health professionals to share this information for research and data analysis purposes. Through "big data," diversified information can be collected from different populations and shared instantly. This helps in research studies, identifying risk factors and recommendation of preventive measures. 2. Improved Communication Innovative technologies have bridged the communication gap between healthcare professionals. Video chats, online discussion platforms, and real-time meetings are just some examples of the communication capabilities that have resulted in improved case management, treatments, and patient recovery. Video conferencing is also a cost-effective way to not only get specialist assistance but also to provide education and training to healthcare staff. This virtual communication bridges the gap between rural areas, and far-flung remote areas. Local GPs, nurses, midwives, health workers, etc. can generate face to face clinical services through teleconsultation to ensure correct treatment and procedures are being carried out. 3. Electronic Medical Records Previously, patient data was stored in different physical locations. But electronic medical records have centralized this system and streamlined it into running more smoothly and efficiently. Electronic medical records are stored in a central online location, keeping all of the patient's history, test results, diagnosis and other relevant information safe. This enables healthcare professionals to see the health trends of a patient quickly and easily. \ 4. Mobility and Mobile Apps Healthcare related mobile software applications are not only cost effective but time-saving also. Such software can enable patients to manage their health status efficiently, get prompted for regular checkups, get assistance in finding general medical information and access 24/7 accessibility to test results without booking an appointment with their doctor. Healthcare professionals can also use these apps to quickly access any medical knowledge, clinical trials or research from these mobile apps. 5. Convenient Digital Forms Healthcare related mobile software applications are not only cost effective but time-saving also. Such software can enable patients to manage their health status efficiently, prompt them for regular checkups, help in finding general medical information and providing 24/7 accessibility to their test results without booking an appointment with their doctor. On the other hand, healthcare professionals can quickly access any medical knowledge, clinical trials or research from these mobile apps. As you can see, technology can have a huge impact on healthcare. Innovations, trends, and digital healthcare services have already improved healthcare services in the following ways: By providing cutting-edge digital platforms Improved operational efficiency Efficient integrated approach to patient care Automated administrative and clinical processes Easy collaboration between different healthcare sectors Higher HIMSS (healthcare information and management systems society) Enhancing the capacity for innovation Better patient outcomes Reduced costs Healthcare has only touched the tip of the iceberg when it comes to technology, but it has already made good use of the benefits of technology and hopefully will continue to do so. Thoughts? Let us know in the comments below!


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DescriptionGot an All Star in your family? Feed them Annie's Organic All Stars, made with fun, certified organic star shaped pasta and a yummy certified organic tomato and cheese sauce. Organic All Stars are perfect for that toddler learning to feed him or herself or for that late night snack in your college dorm room. Either way, All Stars are fun for kids of any age! (from Annie's)Claims
- Organic
- No Artificial Color
- No Preservatives
- Nutrition
- Contains Wheat
- Contains Milk
Water, Organic Pasta (Organic Semolina Wheat), Organic Tomato Paste, Organic Cane Sugar, Sea Salt, Organic Corn Starch, Organic Cheddar Cheese (Organic Cultured Pasteurized Milk, Salt, Non-Animal Enzymes), Citric Acid, Organic Onion Powder, Organic Paprika, Organic Garlic Powder.
Made on shared equipment that also processes egg and soy.
Annie's Homegrown Organic All Stars Pasta in Tomato Sauce
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subset: commoncrawl


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How many recalls happen each year?
A record 53.2 million vehicles were recalled in 2016, according to the National Highway Traffic Safety Administration (NHTSA). Recalls cover a wide range of items, including tires, brakes, air bags and wiring.
How will I be notified of a recall?
Manufacturers are required to notify all affected dealers and vehicle owners. That correspondence offers clear steps, including whether or not you should immediately stop driving the vehicle. The letter tells you who to contact - typically it's a dealership - about repair. The recall notice will also tell you about costs. If your vehicle is more than 10 years old, you may have to pay for repairs yourself.
State registration lists help manufacturers identify current vehicle owners, so it's important to keep your paperwork current. You can also register a vehicle purchase with a manufacturer, which offers yet another way to reach you.
I've heard about a recall but haven't received anything. Can I look up the details?
Recall notifications are sent to the last vehicle owner of record, and these records can be out of date. If you haven't received a recall notice - perhaps you recently purchased a used vehicle - most manufacturers offer an online tool to look up current recalls, based on make and model. It is worthwhile to periodically check for safety recalls by your vehicle identification number (VIN) or sign up for email notifications at either safercar.gov or nhtsa.gov/recalls.
I don't have time to deal with a recall. Do I have to?
Some people ignore recall notices, but a vehicle under a recall may be unsafe to drive. And, if you try to sell it, the unrepaired recall will show up in the vehicle's history. If you get a recall notice, contact your dealer as soon as possible to schedule a fix.


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Función del empleo: Retail Field
Tipo de puesto: Permanent
Tipo de empleo: Part - Time
Localización: Brooklyn, NY
País: United States
NYX Professional Makeup Sales Associate
Kings Plaza- Brooklyn, NY
About NYX Professional Makeup
NYX Professional Makeup, named after the Greek goddess who ruled the night and symbolized beauty and power, is known for high-quality, professional makeup at accessible prices. A leader in the massive color cosmetics industry, NYX is defined by exceptional quality products with rich pigments and high payoff. Featuring a range of classic, seasonal, and on-trend cosmetics, NYX is a must-have among beauty lovers and professional makeup artists. The brand began with artistic inspiration, a single product and a vision. While headquartered in the heart of Los Angeles, NYX is a global brand available in over 70 countries at thousands of retailers consisting of specialty beauty and fashion stores, freestanding shops, and beauty supply stores as well as on www.nyxcosmetics.com.
The NYX Sales Associate will demonstrate exceptional customer service selling skills, operational know how, be knowledgeable in all product categories, and be ready to assist customers with determining their needs. Our Associates are "beauty junkies", with a passion for self-expression and fun. Our Sales Associates are encouraged to foster a collaborative work environment, ensuring a positive internal and external customer experience.
· Consistently creates a welcoming environment for the customer by greeting and assisting as well as quickly responding to customer inquiries and needs.
· Knowledgeable in all merchandise categories and able to make appropriate suggestions to the customers.
· Regularly communicates with Store Manager and Assistant Manager to keep informed on all sales, promotions, and events.
· Complies with all company policies and procedures, including health, safety, and security.
· Assist in the maintenance of the store to ensure cleanliness and organization at all times. This includes all operational needs.
· Maintains open and flexible availability to accommodate store needs.
· Stocks and organizes merchandise as necessary.
· Assist in the execution of merchandise calendar, sales promotions, and events as necessary.
· Performs all duties as directed by supervisor.
· Strong verbal and written communication skills.
· Excellent client service, communication and organization skills.
· Possess strong interpersonal skills to communicate with confidence to both internal and external customers.
· Passion for beauty
· Cosmetic experience and clientele experience a plus.


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Within 24 hours of Seminole County, Fla., Judge Kenneth Lester issuing a stern order allowing George Zimmerman, the defendant in the Trayvon Martin murder case, to post a $1 million bond, the volunteer neighborhood watchman received over $25,000 in donations, bringing his defense war chest to nearly a quarter of a million dollars.
Mark O'Mara, Mr. Zimmerman's attorney, wrote that donors have been lining up for several reasons – that he's been unfairly treated by the media, that he's been falsely labeled a racist, and that donors, if they were in a similar position, would likely have done the same thing.
But in making an appeal for more funds, Mr. O'Mara also suggested on Friday that many Americans have given because they feel "this case is an affront to their constitutional rights," namely the 2nd Amendment right to bear arms.
To be sure, many commentators say the case has mainly to do with Zimmerman violating Martin's equal protection rights by profiling him and then illegally depriving the boy of his basic constitutional right of life.
But judging by the speed and size of donations to the defense fund, it's clear the case continues to provoke a separate debate about America's shifting stance on gun rights and the constitutional case for self-defense.
"People … are definitely thinking and talking about it," Terrence Mayfield, 61, a Florida gun permit holder, told the New York Times a few weeks before the latest bond hearing. "This whole thing rests on who threw the first punch. Either the gun saved Zimmerman's life or we had a cowboy, someone who thought because he had a gun things could escalate."
Zimmerman, who is in late 20s, shot Martin, an unarmed 17-year-old, after a scuffle on the night of February 26 in Sanford, Fla. Thousands of Americans rallied to the side of Trayvon's parents, who demanded justice after local police decided they had no probable cause to disbelieve Zimmerman's self-defense claim.
To Trayvon supporters, the fact that a half-white, half-Hispanic man went free after profiling Trayvon, an innocent black boy, as a criminal, chasing after him, and then shooting the unarmed boy reeked of racial inequality and even institutional racism. Others say Martin is the only one who had a legitimate self-defense claim as he lashed out against a combative stranger following him on a dark street.
But after the state, 44 days after the shooting, decided to charge Zimmerman with second-degree murder, evidence began to emerge showing glaring injuries sustained by Zimmerman to his head and face. While even Judge Lester this week called Zimmerman manipulative, evidence shows he did pass a non-admissible "stress test" that suggested he was telling the truth when he said he feared for his life.
Zimmerman, who was heavier but shorter than Trayvon, has also stated he thought Trayvon was an adult, and that he wasn't sure if he was armed or not. He said he reached for his 9 mm handgun after he believed Trayvon was going for it.
In late May, a Rasmussen poll found that 40 percent of Americans believed Zimmerman acted in self-defense while 24 percent believe it was murder.
While self-defense isn't expressly written into the Constitution, legal scholars have long argued that the constitutional precept of "liberty" implicitly means "the right of self-defense against unlawful violence," according to Thomas Cooley, a 19th century constitutional scholar.
But 40 US states, meanwhile, include in their constitutions both the right to bear arms and to use them in self-defense – concepts that states like Florida and 23 others have built on in recent years with so-called "castle doctrine" and "stand your ground" laws that expressly state that lawful citizens have "no duty to retreat" in the face of an attack, even in public.
Zimmerman's main defense will likely be to seek immunity under the state's stand your ground law.
Critics point to a recent study suggesting that such laws have significantly increased the rate of gun-related killings in states that have adopted them, as the number of what the FBI calls "justified killings" has risen in concord. That study, by Texas A&M researchers, moreover suggests that the laws have not had a significant deterrent effect on criminals.
Yet as concerns about Constitutional gun rights swirl around Zimmerman's defense, the case itself may have sparked more than debate, and may have inspired more Americans to actually use guns to protect themselves and their property, suggests University of Georgia emeritus law professor Ron Carlson.
Speaking about a string of cases in Athens, Ga., where lawful citizens used guns to thwart burglaries and attacks, Mr. Carlson suggested to the Athens Banner-Herald newspaper that "awareness of [Georgia's Stand Your Ground] law spiked after the Trayvon Martin case."
"The existence of this sort of statute places an atmosphere or climate over various forms of human combat," he said. "It helps to create a mindset that is conducive to resistance when one is placed in a conflict situation."
Such readings of America's fundamental laws, especially as spurred on by the Trayvon Martin case, trouble some commentators, including Walter Rodgers, a former Monitor columnist, who wrote recently that "Mexico, Colombia, Syria, Lebanon, Iraq, Afghanistan, Pakistan, Gaza and the West are awash in guns. Their societies are not ones that Americans should emulate."


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A range of fixtures for the testing of composite materials is available, and includes tension, compression, flexure, shear and peel.
The unique nature of composite materials has resulted in the development of these specific fixtures to ensure optimum alignment, high resistance to buckling and precision specimen location.
Most of these fixtures are designed to meet specific materials testing standards. These standards have been developed over the years by leading manufacturers and research organizations, which then made their way into ASTM, ISO, DIN and other standards.
Composites fixtures provide various ways of testing these materials depending on how the material is manufactured and is intended to be used.Type of test: Tension, compression, flexure, shear and peel tests to a variety of established standards.


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Call for info: (888) 983-5748
Last Updated: 20 hours ago
713 Lost Woods Way, McKinney TX 75071
From $364,900 Why 'From' pricing?
New homes can be personalized to your needs and taste.
Builders pricing can vary greatly. Builders display base pricing because you have not selected your options and upgrades yet and some homes may indicate that the land cost is not included.
Library with French doors off entry with 11-foot ceiling. Family room with wall of windows opens to kitchen and dining area. Kitchen offers corner walk-in pantry and generous island with built-in seating space. Secluded master suite includes dual vanity, garden tub, separate glass-enclosed shower and large walk-in closet in master bath. Game room with French doors just off family room. All secondary bedrooms feature walk-in closets. Two-car garage.
Builder Community Sales Office
713 Lost Woods Way, McKinney, TX 75071
Hours: Mon-Sat 10am - 7pm; Sun Noon-7pm
Please be aware that current conditions may impact hours of operation.
Trinity Falls 50'
Situated on the banks of the Trinity River, Trinity Falls is a 1,700-acre master planned community in McKinney, Texas. Enjoy a wide selections of unique and plentiful amenities, fun community events, miles of hike-and-bike trails and more than 450 acres of open space, all just a short drive from historic Downtown McKinney. Students will attend McKinney Independent School District.Visit the website Free brochure
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Caviar Crimes
opens with attorney Tom McGuire on stage in a club pursuing his dream of becoming a stand-up comedian. A disturbance in the audience leads to the discovery that one of his girlfriend Maria's 'clients' at her County job is the aged relative of a man in big trouble with the FBI. Tom reluctantly represents the man and finds himself in conflict with the Russian Mafia.
by Jonathan Schwartz
The Tax Code is more than 15,000 pages long. This book outlines and explains almost every popular argument presented to Federal Courts to explain why one need not pay income tax.
To maintain accuracy, all statements of law have been taken from official IRS documentation, and citations are provided for every case mentioned.
by Edwin H. Sinclair, Jr.
Peter faces a double task: defending a person who is charged with murder, and also trying to locate the missing victim, who was allegedly killed in a completely locked room.
You'll be sitting on the edge of your chair during the suspenseful events that take place in the last few minutes of Peter's client's murder trial.
Peter Sharp Legal Mystery #10
by Gene Grossman
This book is square one for any person seriously interested in criminology; it presents one of the first complete compilations of studies on the relationships between criminals and the rest of society.
Morrison leaves no stone unturned: the reader will even learn the average height and weight of upper-class criminals as compared to those of the middle working class.
by William Douglas Morrison
Unlike many other books that merely provide definitions for a list of words and phrases, Dr. Shoveen goes behind the words that many women use to decode the hidden meanings.
Successful use of the Shoveen method of verbal self-defense levels the playing field and gives men a chance to survive in a relationship.
by Dr. Nick Shoveen, Ph.D.
It is very possible that Mr. Nye might have been an influence on the producers of humorous history films like Mel Brooks'
History of the World, Part I.
From what Nye tells us, "America had many other discoverers besides Columbus, but he seems to have made more satisfactory arrangements with the historians than any of the others."
by Edgar Wilson (Bill) Nye
Written by the same person who created
Phantom of the Opera,
this is considered one of the best locked room mysteries ever devised.
Young journalist Joseph Rouletabille uses reasoning and logic to solve the attempted murder of a scientist's daughter in a room with barred windows and a double-locked door.
by Gaston Leroux
This is Joseph Conrad's classic novel inspired by actual events: the attempt to blow up the Greenwich Observatory in 1894, possibly the first 'international terrorist' incident in Britain.
The story revolves around a beautiful young wife, her simple-minded brother, and her devoted but tortured husband. If you're looking for a happy ending, you won't find it in this book.
by Joseph Conrad
This book is for any person looking to climb the ladder to success. Successful financier Sinclair spent years interviewing successful people about their methods, habits, and rules of behavior.
It covers all the important rules to follow concerning personal conduct both in and out of the workplace, plus 27 requirements that any professionally-oriented person must follow to 'fit in.'
by Edwin H. Sinclair, Jr.


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NEW DELHI, India — Pakistan has rejected India's allegations that Pakistani troops killed two Indian soldiers in the disputed Kashmir region on Tuesday.
Pakistan called for an independent investigation into the incident Wednesday, saying that they are prepared to hold investigations through the UN Observer Group for India and Pakistan, which has people on the ground on both sides of the conflict, according to the Hindustan Times.
The request for an inquiry comes after Pakistani foreign minister Hina Rabbani Khar told reporters in Islamabad that her country "does not believe in tit-for-tat killings," the Hindustan Times reported.
A military official said Pakistan had verified the facts on the ground and found "nothing of the sort" had happened.
The soldiers' deaths have renewed tension in the region, especially after one of the dead men was found beheaded and badly mutilated on the Indian side of the border, according to reports.
Though the Indian army maintains that the soldiers died after a firefight erupted along the Line of Control, part of the contested India-Pakistan border in Kashmir, a senior Pakistani official said Pakistan's troops were not responsible for the attack, AFP reported. The official did not specify whom he believed to be responsible.
Instead, Pakistani officials claimed that the allegations were Indian propaganda, part of a conspiracy to distract the world's attention from an earlier incident in which a Pakistani soldier was killed by Indian troops, Reuters said. India has denied that its soldiers crossed the border, or that they killed the soldier.
On Wednesday, the two countries continued to trade accusations.
GlobalPost senior correspondent in New Delhi Jason Overdorf said that despite the recent cease-fire, periodic exchanges of fire are routine across the "Line of Control" that separates Indian- and Pakistani-administered Kashmir.
"But the ill-timed beheading of an Indian soldier by marauding Pakistani troops has likely put paid to the peace process — which has already been running on fumes," Overdorf added.
Indiana University and expert on the conflict Sumit Ganguly told GlobalPost that the so-called peace process died a long time ago.
"The way out is to ignore Pakistan for the next 20 years and focus the country's energies on tackling a plethora of domestic problems," Ganguly said.
Two of the three wars that India has fought with Pakistan since the two countries gained independence from Britain in 1947 have been over Kashmir. The latest, the so-called Kargil war, was fought as recently as 1999.
But despite the alleged incursions by Pakistani soldiers and the beheading, not to mention the rancor lingering in India over the Nov. 26, 2008, terrorist attacks on Mumbai, there is little chance that the end of the peace process will mean a move toward a real shooting war.
"It is highly unlikely that this spat will lead to a Kargil-like scenario," Ganguly told GlobalPost. "At worst it will lead to more skirmishes. With a very weak PM at the helm, a foreign minister eager to do his bidding and with plenty of domestic woes, India will do all to tamp down on possible escalation."
For Indians, the beheading was unexpected, marking a return to a level of brutality not seen since the Kargil war.
Indian Defense Minister A. K. Antony said that the "Pakistan army's action is highly provocative," while the Pakistani foreign ministry said India's allegations are "baseless."
"The way they treated the dead body of the soldiers, Indian soldiers, is inhuman," Antony said, referencing reports that one of the soldiers was beheaded and mutilated, the AFP reported.
India summoned the Pakistan envoy to Delhi to speak with its foreign minister following the alleged incident. Though Salman Khurshid said that Pakistan's envoy had been "spoken to in very strong terms," he warned against further escalations between the two countries, AFP reported.
"Whatever has happened, should not be escalated. We cannot and must not allow for an escalation of a very unwholesome event that has taken place," Khurshid said during a press conference.
Shortly after India's accusations, Pakistan Chief of Army Staff General Ashfaq Parvez Kayani emphasized the need for the army to remain fully prepared to respond "the full spectrum of threat."
Kashmir is a Himalayan region that India and Pakistan have both claimed since gaining independence from Britain in 1947. The British allowed the state, formally known as Jammu and Kashmir, to choose whether it wanted to be a part of India or of Pakistan. Though Kashmir had a majority Muslim population that favored acceding to Pakistan, the leader of the state was a Hindu. He opted to join India, handing powers over to the central government in New Delhi in exchange for military protection.
After the first war, the UN adopted a resolution calling for a referendum that would allow the people of Kashmir to choose which country they wanted to join, but the vote has never been held.
Jason Overdorf contrinbuted from New Delhi, India. Mariya Karimjee contributed from Karachi, Pakistan.


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By Jason G. Umans, MD, PhD
It's time to resolve the lack of knowledge about optimal use of medications in pregnancy. Despite advances in drug research and policies surrounding clinical trials, we still don't know about the safety of most drugs or the full risks of untreated disease to both the mother and fetus (unborn baby). Indeed, most women and their physicians would be disappointed by how little we really know about the optimal use of medications during pregnancy.
Prior to 1993, pregnant women (or women who might conceive) were specifically not included in drug clinical trials. Thus, most of the safety data for prescribing drugs during pregnancy are either extrapolated from animal data (which can either underestimate or overestimate risk in pregnant women and their unborn babies) or from limited, often uncontrolled reports of "off-label" drug use (use for other purposes than the intended treatment) or adverse outcomes during pregnancy.
The optimal dose of a drug used during pregnancy should maximize therapeutic benefit while minimizing the risk of damage or toxicity to the mother, fetus, and placenta. Obviously, too high a dose could cause toxic effects, out of proportion to therapeutic benefits. Less obviously, too low a dose may deny women any benefits of treatment, while still exposing them to some risk.
Determining the best dose is difficult because a woman's ability to metabolize and excrete drugs, as well as her body's response to drugs, changes dramatically over the course of her pregnancy. A case in point is that most drugs are eliminated from the body either by enzymes in the liver or by excretion into the urine, and the activity of both of these processes can be increased by up to 50% in most pregnant women. This fact is rarely taken into account.
It is a basic principle of pharmacology that, when we weigh potential harms of a drug treatment, we should do so at a dose and dosing interval that maximizes potential benefit. Unfortunately, we lack this sort of dosing information for almost all drugs prescribed to pregnant women. Most women will require one or more prescription drugs during pregnancy despite the fact that almost no commonly used drugs have been tested specifically for their use in pregnancy. Consequently, while we always have some information about fetal safety (more often in animals than in humans), we know almost nothing about maternal safety, about choosing the right dose for a pregnant woman, or about how effective the drug will be during pregnancy.
My colleagues and I continue to be amazed that in the 21st Century, in most cases, physicians have to use their best judgment to weigh risks and benefits, even though they rarely know the optimal dose of a drug that should be prescribed to their pregnant patient or the full risks of untreated disease.
It is the job of clinical trials to determine safety and efficacy, including proper dose response. Men comprise the largest proportion of subjects studied in most drug research. In most cases where there are data, research has shown that different (and, surprisingly, often higher) drug doses are required to achieve the desired drug effects in pregnant women in comparison to non-pregnant women or men. We ask, "Is the choice of not treating a woman during pregnancy better than dealing with the challenges that accompany finding the best treatments?" Surely, "yes" cannot be our answer for this would deny women the potential benefit of newer and, perhaps, safer and more effective drugs than are used currently for underlying maternal illnesses. Furthermore, we need to accelerate the development of sorely needed drugs to prevent or treat disorders unique to pregnancy such as preeclampsia, preterm birth and fetal growth restriction.
Current medication labeling with respect to pregnancy is dictated by law and regulated by the US Food and Drug Administration (FDA). This labeling typically reports only on fetal safety issues with respect to the use of the medication and provides no information on changes in drug dosing or effectiveness during pregnancy. For decades, the FDA has used a system of letter categories to classify drug risks to the fetus, focusing overwhelmingly on evidence of birth defect risk, without consideration of the risks of untreated or undertreated disease and of appropriately tailored drug use in pregnancy.
Adequate and well-controlled human studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
The FDA system differs from grading systems in other countries by depending more heavily on animal data when human data are limited and having fewer, broader, and less specific categories. Most drugs used in pregnant women fall in FDA category C. This is anything but reassuring, as the drugs in category C have not undergone adequate and well-controlled studies in humans and have been correlated with adverse effects on the fetus in animal studies.
Several category D and X drugs are also used in pregnant women. For example, aspirin, a category D drug, is commonly used. There are cases in which category D drugs are apparently safe and crucial to the health of pregnant women and their fetuses, such as drugs used to prevent rejection of transplanted organs, despite these drugs being placed in a category defined by studies indicating risk of fetal abnormalities in humans.
An additional quirk of the FDA classification system is that drugs without proven indications in pregnancy will be classified as category X, by default, even without clear evidence of fetal risk, since they are considered to be "without benefit" and therefore must have an unacceptable risk/benefit ratio. By contrast, the "X" category in either the European or Australian fetal drug risk classification systems is reserved for drugs that have such a high risk of permanent harm to the fetus that they should absolutely not be used. This issue is important for the current classification of all statin drugs (which are classified as D, rather than X by the Australian regulators), as these have not been considered previously to have any indications for their use during pregnancy.
There are several interesting examples how research can change everything. One of the major problems with assessing fetal risk is that birth defects occur in approximately 3% of all healthy pregnancies, so we would still observe birth defects (and might suspect fetal dangers) in 3% of women who take even a perfectly-safe drug during pregnancy. Indeed, a classic example relates to the drug BendectinTM-a combination of pyridoxine and doxylamine, which was widely prescribed for "morning sickness" in the 1960s and 1970s. It was removed from the market after a flood of lawsuits blaming it for causing birth defects (without any controlled studies). It was then subjected to perhaps the largest series of studies of drug safety in pregnancy, proving its safety beyond any doubt, leading to the dismissal of all of the lawsuits, and to its classification in category A. This is why controlled studies are so important. By contrast, ACE inhibitors, a class of antihypertensive agents, were originally classified as FDA category C. The classification was only changed to D years after many reports of toxic effects on the fetal kidneys in the latter part of pregnancy. Finally, perhaps surprisingly, among the best and most thoroughly studied of all drugs in pregnancy are those for the treatment of HIV infection, many of which are now classified in category B, and used to effectively prevent the transmission of HIV from mother to fetus. We are fortunate, in a sense that everyone agreed the stakes were so high that the study of these drugs was necessary in pregnant women, rather than leaving physicians and their patients to guess at safety and the right doses to use during pregnancy.
The FDA has long recognized the current system requires a major overhaul to be more informative and useful to clinicians and patients. Over five years ago, major changes to both the pregnancy and lactation subsections of drug labels were proposed (http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/Labeling/ucm093307.htm) to include a narrative summary of risks, clinical considerations to support patient care decisions and counseling, and a data section with more detailed information. The proposed regulations would eliminate the current pregnancy categories A, B, C, D and X in favor of categories that more accurately and consistently convey risk and benefit. Unfortunately, we are still in limbo between the phase-out of the old letter categories, which appear in all textbooks and review articles, and the new, more informative approach, which is yet to be implemented.
Jason G. Umans, MD, PhD is Scientific Director of the Biomarker, Biochemistry, and Biorepository Core Laboratory at MedStar Health Research Institute, Director of Research Education and Training for the Georgetown-Howard Universities Center for Clinical and Translational Science, and serves as Associate Professor of both Medicine and of Obstetrics and Gynecology at Georgetown University. Dr. Umans, an internist, nephrologist, and clinical pharmacologist is also an American Society of Hypertension (ASH) Specialist in clinical hypertension who has devoted most of his efforts over the past two decades to the care of medically-complex pregnant women and to research focused on preeclampsia and on drug therapy in pregnancy. He received his MD and PhD in Pharmacology from Cornell University, and completed clinical training in Medicine and Nephrology at the University of Chicago. Prior to joining MedStar, he held faculty appointments at Cornell, Chicago, and Georgetown. He is internationally recognized as an expert in medical disorders during pregnancy, particularly hypertension and kidney disease. His research in clinical pharmacology focuses on pharmacokinetic and pharmacodynamic studies in pregnant women. Additional research interests include vascular mechanisms and risk factors for hypertension, kidney, and cardiovascular disease. He has published approximately 150 original papers on obstetric-fetal pharmacology, preeclampsia, pharmacokinetic modeling, drug assay development, neuropharmacology, vascular and renal physiology,, inflammatory mechanisms, and cardiovascular and metabolic diseases. He has written book chapters and review articles, and has spoken widely on hypertension and renal disease in pregnancy,and on pharmacotherapy in pregnancy and in renal failure.


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Protect (formerly known as Public Concern at Work) is an independent charity that provides confidential advice on whistleblowing issues. We have handled over 40,000 cases and the number of calls increases year on year. We are running at a deficit and need your support to reach out to more workers and ensure they are empowered to speak up to protect us all.
We want to ensure that we are able to offer free, confidential advice to all of those who need it, to speak up in the workplace. If you have found our assistance useful and/or would like to support our work on whistleblowing, you can donate in the following ways:
You can make a donation from your mobile phone by texting 70070 with the words PTCT25 and state the amount (up to £10) you wish to give. So, for example, to donate £10 text the words: PTCT25 £10 to 70070.
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Rigau Brut
[T]he briefing was very clear, "… we want to go out of the current idea that cavas and champagnes always must transmit a serious and formal image …". The challenge deserved a good dissertation on what this type of product means to the public and that time is consumed and why. After working in different conceptual lines we finally choose this one. The proof that to change pre-established concepts is evolution and that means fresh air in an industry that since a long time ago doesn't transmit new emotions.
Design by The Yes Brand


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Williams gives teammates scouting report on Angels
HOUSTON -- Astros relief pitcher Jerome Williams, who spent the last three years with the Angels, has been helping out his current teammates during this weekend's series against the Halos by giving some scouting reports about his former team.
"I know every last one of them over there," said Williams, who went 9-10 with a 4.57 ERA in 37 games (25 starts) for the Angels last year. "Besides [David] Freese and the bench besides [Hank] Conger, I know everybody there. I know their swings; I know what they try to do."
Williams even has a knack for how veteran manager Mike Scioscia operates during games. He anticipated a hit-and-run earlier in the series with John McDonald at the plate and Erick Aybar on base.
"He put that lineup out there for a reason based on how guys produce, and he wants to have guys that have roles that know what they can do," he said.
When it comes to Mike Trout, Williams said the secret is to pitch down in the zone. Trout was 1-for-5 on Saturday with three strikeouts.
"You can still get a ball down in the zone and get him out," Williams said. "It happened with [pitcher Dallas] Keuchel and it happened with Matty [Albers]," he said. "He's still human."


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Xbox 360 Games
This page contains Cheats for Sphinx And The Cursed Mummy organized by sections for Xbox 360. This game has "Action Adventure" as genre, made by Eurocom, released on Jun 11, 2019. If you can't find a hint or secret in our list, then please check this page periodically for the latest updates.
Boxshot & Details
- Developer: Eurocom
- Publisher: Thq Nordic
- Genre: Action Adventure
- Release: Jun 11, 2019
- ESRB: Not Set
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If you know cheat codes, secrets, hints, glitches or other level guides for this game that can help others leveling up, then please Submit your Cheats and share your insights and experience with other gamers.
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All-rubber V-rings
All-rubber V-rings are used for rotating shafts in an extremely wide range of applications. The V-ring can be used alone to protect a wide assortment of bearing types from contaminants while reliably retaining the lubricant. They are also often used as secondary seals to protect primary seals in highly contaminated environments.
V-rings are installed on shafts and their thin, tapered lip seals against a counterface perpendicular to the shaft (fig 1). V-rings have an interference fit on the shaft, rotate with it and act as flingers (fig 2). Angular misalignment of the shaft relative to the counterface can be tolerated (fig 3). V-rings provide reliable sealing even if the shaft is out-of-round or rotates eccentrically (fig 4). The amount by which the shaft can be displaced axially is governed by the permissible displacement of the V-ring relative to its counterface.
V-rings are made entirely of elastomers without fabric or metal reinforcement and are therefore easy to install. They can be stretched and, depending on size, pushed over other components like flanges, pulleys or even housings. This is a very valuable feature, especially when replacing a seal.


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More often than not, the fishing industry is given access to fish stocks before the impact of their fishing can be assessed, and regulation of the fishing industry is, in any case, woefully inadequate.
The reality of modern fishing is that the industry is dominated by fishing vessels that far out-match nature's ability to replenish fish. Giant ships using state-of-the-art fish-finding sonar can pinpoint schools of fish quickly and accurately. The ships are fitted out like giant floating factories - containing fish processing and packing plants, huge freezing systems, and powerful engines to drag enormous fishing gear through the ocean. Put simply: the fish don't stand a chance.
Populations of top predators, a key indicator of ecosystem health, are disappearing at a frightening rate, and 90 percent of the large fish that many of us love to eat, such as tuna, swordfish, marlin, cod, halibut, skate, and flounder - have been fished out since large scale industrial fishing began in the 1950s. The depletion of these top predator species can cause a shift in entire oceans ecosystems where commercially valuable fish are replaced by smaller, plankton-feeding fish. This century may even see bumper crops of jellyfish replacing the fish consumed by humans.
These changes endanger the structure and functioning of marine ecosystems, and hence threaten the livelihoods of those dependent on the oceans, both now and in the future.
The over-exploitation and mismanagement of fisheries has already led to some spectacular fisheries collapses. The cod fishery off Newfoundland, Canada collapsed in 1992, leading to the loss of some 40,000 jobs in the industry. The cod stocks in the North Sea and Baltic Sea are now heading the same way and are close to complete collapse.
Instead of trying to find a long-term solution to these problems, the fishing industry's eyes are turning towards the Pacific - but this is not the answer. Politicians continue to ignore the advice of scientists about how these fisheries should be managed and the need to fish these threatened species in a sustainable way.
These past few days, the public saw the country's premier hotels and restaurants inviting their patrons to join them in saving the oceans by scrutinizing the seafood that are served and consumed. The decision of the hospitality...
Fishing is not quite what it used to be. Even in the Pacific where images of sunny shores, palm tress and little canoes may prevail, reality underneath the waves is quite something else. Some of the biggest and most powerful fishing...
The annual meeting of the Western and Central Pacific Fisheries Commission (WCPFC) is scheduled to kick start in Manila, Philippines on December 2, 2012. On board the MY Esperanza, we've just completed the last leg of the "Defending...
Greenpeace ship MY Esperanza is in the final part of the "Save our Oceans Asia Pacific Tour" after visiting South Korea, Taiwan, Hong Kong, Palau, and is now en route to Manila for the upcoming Western and Central Pacific Fisheries Commission...
You have the power to protect our oceans!
On board the African Queen, one of MY Esperanza 's inflatable boats, we approached GENEVIVA, a purse seine fishing vessel from the Philippines. As we got nearer, the crew from the ship gave their genuine smiles and even gave us a hand...
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Press release


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Vue Apartments seek temporary occupancy permits
Construction continues on student apartments
The Vue Student Apartments in Fayetteville, where two construction workers were killed, is one step closer to getting the green light to open its doors to tenants next month.
40/29's Ugochi Iloka reported from the construction site that the Fayetteville City Planning Department said the Vue Apartments have a long way to go before they can let students move in, but the city's Fire Department said at least one of the buildings has passed all of its inspections.
"I believe Building 4 has passed the life safety inspections for the Fire Department, and their sprinkler alarms are working and they had adequate protection," said Fayetteville Fire Chief Harley Hunt.
Hunt said that although the sprinkler and fire alarm systems are works in Building 4, a couple of weeks ago that was not the case. He said they failed the earlier inspection because some of the necessary safety items were not in place.
"They just weren't ready," Hunt said.
40/29 News learned passing the fire code inspection doesn't mean the Vue qualifies for a temporary occupancy certificate-furniture only. Fayetteville City Planning officials said a building inspector has to also approve all necessary health safety codes related to the interior of the building.
Hunt said although the process of making sure each apartment meets the fire code takes about three hours per building, something could be missed.
A college student who lives close to the Vue told 40/29 News that regardless of whether the apartments pass inspections, past incidents at the construction site makes her question how safe the buildings are.
"The construction isn't legit," said University of Arkansas student Mia Melton. "I mean, people have been dying. I wouldn't recommend living there."
The Vue is trying to get furniture in during the building stage. The final occupancy certificate is what they need to allow students to move in. Fayetteville City Planning officials said that will require multiple city divisions to inspect the property.


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A forum about Atari 16/32 computers and their clones. This forum is in no way affiliated with Atari Interactive.
Moderators: lotek_style, Mug UK, Moderator Team
Dal wrote:I'm intrigued to know what the point was in applying copy protection to demos?
AtariZoll wrote:you can make 880K in regular format. More than it is possible, but only little - and using read track.
alexh wrote:Thalion Sound Demo. It's a protected dual format Amiga/ST disk. It was cracked for the Atari ST "side" by OSE, TORBJØRN (aka Lord Hackbear) and I had a friend Mr.Larmer (RIP) create a WHDload for Amiga
AtariZoll wrote:Dio, I really don't get why you write this. Many people used Hyperformat with success, and even some commercial games have such, 11 sect/track format.
troed wrote:Dal wrote:I'm intrigued to know what the point was in applying copy protection to demos?
Not copy protection - in the cases where the special format (not using FAT allows you to gain extra space) couldn't be copied with system or common copiers the demos themselves included a copying screen
Dio wrote:...
I wrote it because I've looked at the spec.
Anything done at the duplicators I can certainly believe because read sector timing is more flexible than write, and since it's track-at-once written there aren't any write splices. Given that the PLLs should stay locked for the entire track, it's not out of the question you might even be able to eliminate all the 0s on the index PLL lockup and save a full 12 bytes there (although that might again require interleaving, and the CAPS FDC claims the FDC won't respond to a DAM closer than 28 bytes to the end of the index header so there's nothing to be saved on the data side).
Code: Select all
hyfil dc.b 11
dc.b 1,7,2,8,3,9,4,10,5,11,6 *sec No-s, interl. 6
*GAP-s for hyperformat
trleadh dc.w 3
dc.w 4
dc.w 5
dc.w 9
dc.w 5
dc.w 34
Brume wrote:I didn't know the original was protected.
Dio wrote:However, you can build a completely legal 880K disk that can be read and written on the ST using 5 large and one normal sector per track (even with only 6190 raw bytes there's still more than 80 bytes per sector available). I'm surprised more commercial games didn't do this.
Hi Udo,
Thanks for answering. I guess you forgot after all this time, but no,
there are no single 6k sectors on Dragon Flight.
Track 0 is indeed standard and the rest are not. Tracks 1-79 have six
sectors, five 1k sectors plus one 512 bytes sectors. This gives you
5.5 Kb per track, exactly the same capacity as "standard" 11 sectors
per track, but your track layout is much more reliable. All 3 disks
have exactly the same format/layout except that the last one is
single sided.
As a matter of fact, there is no such thing as a 6k sector on the ST.
The FDC doesn't support sectors bigger than 1k. It is possible to not
use sectors at all, and use a raw track with a capacity approx. of
6k. Some ST games use this format. But this is not very reliable, and
this is not the case on Dragon Flight anyway.
If you don't have original disks anymore, I can send you a Dragon
Flight's disk image with the copy protection and custom format
intact. It runs under the latest version of Steem perfectly well
exactly the same as the original (as with the original, you have to
create and use backup disks). You can use disk analysis tools to see
the track layout or you can even log and trace the disk reading and
copy protection. But you have the source, so I guess you should be
able to verify that you are reading 6 sectors per track.
Also, this custom format has no relation to the disk copy protection.
I mean, there is a disk copy protection on Dragon Flight that is
separated for the custom format. The custom track layout is not
actually a protection because most ST software copiers would handle
it without troubles. The protection is not in the sectors, is outside
the sectors. I'm not sure how much you want to talk about this, so
I'd prefer to avoid giving details without your authorization.
However, I consider that the most interesting aspect in Dragon's
Flight protection, is the one present in the "Backup disks". It is
exactly the same as in some famous ST copy protected demo. It is
a "seudo" protection because, obviously, the protection can be
created and copied in the ST itself. But the concept is quite unique
and brilliant. Hats off to you (or to Michael, or to whoever came
with the idea). Again, I'm intentionally avoiding being more specific.
AtariZoll wrote:Here is short part from my floppy format/copy SW:
Dio wrote:AtariZoll wrote:Here is short part from my floppy format/copy SW:
Thanks for that, very interesting. Can you tell me what each of the GAP sizes is used for?
npomarede wrote:Hello
I have KF image of The Union Demo that MugUk sent me, as he was kind enough to dump it one year ago when I was working on IPF support for Hatari.
Brume wrote:- The Overscan Demos by Paulo Simoes. If i remember correctly, it was hacked by Paulo Simoes in order to make a .ST/.MSA file
AtariZoll wrote:There is contradiction. What can be imaged as MSA or ST is not considered copy-protected. There is a lot of SW what can put them in image, and write onto floppy, reproducing 100% working copy. No FAT, no visible files ? It will not prevent hackers to steal code.
Extra space may be the reason, but you can make 880K in regular format. More than it is possible, but only little - and using read track. I really would like to see some demo with it
Since Ijor has Union demo on his Pasti site, it must have some real copy protection.
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