text:
Who Are the Top Retailers on Social Media? [INFOGRAPHIC]
It's become practically mandatory that brands incorporate social media into their business strategy, causing retailers to compete for popularity in stores and on the Internet, too.
Campalyst has provided this infographic, which covers the largest Internet retailers in the U.S., and their presence on the five key social networks: Facebook, Twitter, YouTube, Google+ and Pinterest.
Victoria's Secret is the top retailer on Facebook, with nearly 18.5 million fans, followed by Walmart with about 15 million fans. According to Campalyst, 97% of the Top 250 Internet Retailers are on Facebook, and average number of fans there is close to 1 million.
On Twitter, Major League Baseball is the leading Internet retailer account with 1.9 followers. The brand also has the most on Google+, boasting more than 600,000 followers.
Retail channels on YouTube do not show numbers as large as the other social platforms. Nike has the most subscribers with more than 200,000.
Pinterest is still relatively new to the social media game, which explains why its numbers are the lowest. It may also suggest that the platform is better for user-generated content, rather than retail. Nordstrom leads on Pinterest with more than 14,000 followers.
The infographic also breaks down what retail industries are leading on each platform. For example, apparel/accessories average 100,000 followers on Twitter, while computers and electronics only average about 62,000 — yet computers and electronics is the top industry with subscribers on YouTube.
Take a look at the stats below and let us know what you think. Do any of the retail brands or industries surprise you? Is retail suitable for all of these platforms? Share your thoughts in the comments.
Thumbnail image courtesy of iStockphoto, pressureUSA


text:
epic fails all round
i was asked to take 10% paycut last month which clobbers me as im already paid peanuts for talking to idiot users, time to abandon ship?
A survey of advertised IT salaries reveals a slight fall since last year, with little prospect of increases in the immediate future. Researchers looked at 6,000 advertised positions and found the average salary for a permanent IT position is now £36,092, down one per cent on last year. All the ads appeared in the first quarter …
It's not in London either. In fact has anyone here actually seen much of a pay rise over the last 10 years ?
I would blame out sourcing, but pay is bad there as well, as is conditions, and how many of us (including out sourcers) have been told that our salaries are sector competitive and stop the bean counters moving everything to India.
Agencies always advertise consistently at the high end of any pay range. They get a dollop of cash that represents 20% of the candidate's starting salary, so they always try and talk the market up, for that reason. Whenever I've been looking for work, it's been as thought the agent was sitting between the employer and me, controlling what message went backwards and forwards, regarding starting salary. I imagine, with greater competition, most agents are pitching more and more candidates at the same roles, so many of them are aiming their prices lower, to try and get the deal, simply because 20% of anything is worth more than 20% of nothing.
In an ideal world, a candidate would start at probationary rates and then be awarded a post-probationary pay rise, based on proven preformance. As it is, companies get asked to stump up full salary starting schemes, while being deluged with the CVs of people who don't know that Javascript isn't the same thing as Java, from agents who don't realise that clients looking for XML specialists might be interested in someone with experience in SOAP.
Lots of companies with want ads but lets say you match the ad they are posting by 99.9% and you do not have that 1% skillset then you are not hired but whereas an H1B visa holder can just have 75% of those skillsets and be hired full time at reduced pay.
This is why certification is worthless. The more certs you have the more you have to match the skillset they want whereas I have none and can do it all but have to put up with these H1B.
The sad story of H1B is once they get american citizenship and get full time then they will be fired or replaced by a H1B who does not aspire to become a US citizen.
Possibly worth mentionning to the boss that, if like me, you haven't had a pay rise in the last few years, then compared with the cost of living your salary is already more than 10% reduced.
Only way I'd accept this is to have it in writing that when things recovered I'd get the 10% back with interest and a noticable rise as well. (effectively meaning I'm lending the company 10% of my salary until times improve, which they have to pay back as soon as they can).
Paris, 'cos I don't think she'd be happy with any less than she's getting....
. . . and you get the satisfaction of contributing less towards MP's second homes, fake tudor beams, banking subsidies etc.
The closest I've come to employment in IT for the past ten years is writing comments here! It no longer makes sense to move from project to project in the crowded, expensive south east in order to earn a plausible salary, with skills which are easily the match of a GP's or solicitor's, but are short lived (IT skills must be constantly updated), now underpaid, and unprotected by the closed shop with restricted entry that keeps the earnings of the "professions" high.
Employers are in any case largely unable to tell the difference between the best and the worst, despite the difference amounting to maybe a 60-fold ratio in problem solving productivity between best and worst.
I work outside London as a developer in a full-time position and my salary is around £55K. Surely for every snotty-nosed web designer right out of college there's an experienced developer on £60K or thereabouts? Or have I got the wrong idea about salaries in this sector? I admit, it's been a while since I was on a job hunt.
As an Outer London based employee from 1998 to 2000 I was on an overall package (inc car, pension etc) worth approx £50K.
Surprised to see only £36K now being quoted.
As I am self-employed I can no longer compare things. But I wouldn't be happy accepting a full time employed position at that rate - although it would be nice to get paid holidays, sick days, etc!
Salary depends on what you do. If you're a Windows admin, code cruncher, help desk techie, etc., you aren't worth much. The world teams with people with these sckills and outsourcing these activities is cheaper. However, if you are a Big Iron admin or DBA, with years of experience, a systems architect, software engineer, etc., you're still in high demand and can ear very good money.
Monkeys get paid peanuts. If you are a helpdesk chimp then you aren't going to get paid as much as the grown ups, that's just a matter of fact.
Oh and recruitment agencies are scum and serve no purpose in a world with sites like Monster and Totaljobs (and El Reg's own wonderful job site).
Define a helpdesk chimp these days! Some helpdesk chimps are expected to be able to be able to solve every single problem at the first point of contact and sweep up behind them with that handy broom up their arses. The trouble is, and I think I speak for many and not just for the tea party, that the people making the decisions on pay often don't know how much goes into a decent IT operation, whatever the level.
As the computer becomes yet another white good, just as the television did before it, the radio before that and so on, the average pleb boss considers the support of said kit a menial task and awards a salary reflecting his perception of the job. Everything can be done in a couple of key clicks and can be done yesterday, yet I don't see said pleb boss getting his hands dirty!
As for the guy earlier with his thoughts about recruitment consultants, he obviously never heard that you should never trust them any further than you could comfortably spit a rat. If helpdesk folk are monkeys, then RCs are snakes!
I was paid more (well the same) fifteen years ago -- daily rates are the same now as they were in the 90's. In addition, I often got paid to attend interviews then, whether I took the job or not.
I once got £400 to just go and be interviewed by a pharma corporation (around 1995, I think) and this was because they regarded me as a professional person and the trip to the interview was something they felt ought to be compensated for at a professional rate whether I took the job or not. It was just a short train journey from where I lived and didn't accrue any other expense. To be fair it was more a consultation and a civilised chat than an interview but it did determine whether or not they offered me the job. They did in the end.
Maybe I'm just an old square from the past but today "interviews" are usually conducted (or should I say "committed") by the most dull, self-aggrandising ignoramuses it has been my misfortune to meet.
How times have changed!
Like I told the engineer way back when, "If you going to take their money, do their job. If all you can do is bad mouth the company, if it's that bad why are you still here?".
If it's so bad, get the hell out. Should be a wise move since IT people are so good and so much in demand.
Yeah, some of us old dinos still work on mainframes. There are a lot of people telling us we're going away. We've been "going away" for the last 30 years. The biggest problem is they really aren't training a lot of folks to take our place after the next big extinction.
"Or have I got the wrong idea about salaries in this sector?"
I'd suspect it's a combination of that, getting a bit lucky, where you live and timing.
As an experienced developer I don't earn anything even close to the average mentioned, but my living costs are very very low so I could afford to take a job with an interesting company writing exciting product. I consider myself lucky getting a new job at the pay I got given the current times but I'm fairly sure the numbers in this article are wildly skewed over national numbers - I know for sure I couldn't even dream of living in London on what I get paid though.
Ive seen the offshore pressure affecting all of the market sectors, I contract and in a very specialized niche and we're seeing less emphasis on doing things properly and much more on doing them cheaply with everyones lust for results and not to pee off the board at end of year figures time. So a lot of what would have been done properly onshore has gone offshore just to massage the figures in a bid to not be slayed by the city on shareprice at results time.
The problem is the phb's cannot really see the difference in the end product, don't understand theyre putting stuff out thats not really fit for purpose and running the companies into the ground.
It will probably take several years for the bad companies to reap the rewards of what they are sowing now to stay alive, and be replaced by a new batch of people wanting to do things properly who wont do stupid things like allowing nobody technical to speak to the staff resourcing dept or recruit people by name/reputation direct, at which point there will be another equivalent of the .com boom when the majority of the trainwrecks stop happening, some market confidence comes back to IT projects and all those plumbers will suddenly be IT workers once more, and all the IT recruitment agency staff will stop being estate agents again!
To all the developers agog at the numbers, its often said that our specialized team all STARTED off as developers many years ago. Times are hard, but its about now you should be rounding off your skillset and taking a look at the next few rungs on the ladder.
Have to say, if someone offered me 36k for my next role, Id take a year off instead, but I have worked my arse off through the ranks getting to my fortunate position...
Certification are usually a waste of time. Experience is what counts.
If I was to be certified for everything I do, I would need to spend a month taking exams. Technology moves so fast though that any exam is usually out of date a year or two after it's been written. I don't have time for that. In the current scheme of things you have to know where to find your help and you need to know how to use it and apply it. (I have huge and expensive cisco books on the shelf, but I never use them because the Cisco site contains more info. I have another £40 book on networking from 20 years ago - but it only has a cpl of paragraphs on tcpip!)
Certificates etc - there are ppl that make money by sitting the same exams many times (each time with a different name on the paper) When I was at uni, on one of the exam papers, the invigilator asked a baby and the babysitter to move further apart. When the baby complained he was moved to the front and only scored 10% on that paper - his other papers were 80% or more. I've worked with plenty of idiots who clearly have not passed their exams - or if they have then they have quickly forgotten what they learnt, or never understood stuff in the first place.
When companies like Amazon, Google, IBM, Plusnet, Tiscali and Tesco mess up big style, you have to question the quality of their staff - far too cavalier. These are the ones that need sacking in the current climate.
People working in the IT industry need to realise that their jobs are always on the line. Anything which can be done remotely will for large companys be done remotely. I've heard of pay rates as low as $2 per hour so that might explain why some of the large companies who are keen on outsourcing are having such a hard time of it at present. Righsourcing, leftsourcing, upsourcing, downsourcing, insourcing, subcontracting, downcontracting, etc - it's always cheap labour.
A large uk telco, popular with some large banks btw - they make many mistakes. I know a lot of the techies and asked them about some of the mistakes. Yep, outsourced.
HP. Started with just a few guys in a shed. Google started with a cpl of lads and a garage. This could be a model for the future. Outsource everything - design, manufacture, support, marketing, accounting, sales, distribution, warehousing. All you need is a couple of guys to pay the big wad of dosh called profits to. (Profits, who needs them? Pay yourself a big wad of dosh anyway while the gravey train rolls - and preferably before anyone looks under the rug.)
From the previous posts it looks like a lot of IT people at not earning the average and never expect to earn the average, so the average is going to stay low.
Why not upskill and get a better job. People are happy to pay out of their own pockets for leisure activities. Golf lessons, gym memberships. But, when it comes to doing soemthing that will increase their earning potentialy they expect their employer to pay up.
Why not invest some of your own free time and money so you can get a better job and earn more money then you can pay for more golf lessons, Xbox games, techie t-shirts, odd bits of kit from random websites...
It's not alwys your employers job to improve your earning potential.
Biting the hand that feeds IT © 1998–2020

subset: commoncrawl


text:
The folks at the Bonobo Great Ape Trust Sanctuary of Des Moines, Iowa have a noble goal — to build their bonobos a teleoperated RoboBonobo so that the apes can interact with their environment using a mechanical avatar.
In practice, this means strapping a grinning monkey head to a droid, equipping it with a water gun, and allowing the horror to unfold while strains of the Benny Hill theme toodle softly in the distance.
We jest, we jest! Bonobos can utilize a vocabulary of approximately 400 words, and the Bonobo Chat and RoboBonobo projects would offer the apes an opportunity to expand their interactions using the internet and other computer technology.
The team seeks to raise $20,000
to build this undying ape-machine army to make human-ape communication history. Here's their pitch:
We would like the bonobos to use the Bonobo Chat app to control their environment using simple lexigram commands - to operate vending machines, open doors, watch movies and, hopefully, to control robots. We believe that controlling robots might be a good way for the bonobos to interact with guests and visitors outside their caged areas. They could play chase games or squirt guests with an onboard water gun.
[RoboBonobo via IEEE Spectrum]


text:
- 1.2 Trick Pony - Sandwich
- 2.Track 8
- 3.Fireflies
- 4.Sandwich - Butterfly Carnival
- 5.mga kababayan
880 members18230 Comments 89 Likes
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Started this discussion. Last reply by Lheins loyola Dec 7, 2011. 2 Replies 0 Likes
That's according to Sorsogon Bishop Arturo Bastes, who recently chastised the Kapisanan Ng…Continue
Started this discussion. Last reply by AgeOfAtheists14 Oct 9, 2011. 6 Replies 0 Likes
this is a short story about a girl who is "lesbian"...who "love" to make some seminars and forums to help people with emotional and spiritual problems..who love to make some "party for a cause" and…Continue
Started this discussion. Last reply by Lheins loyola Apr 30, 2012. 2 Replies 0 Likes
I was suffocated surrounded by believer people..believer of different Gods even they doesn't know how god exist..I'm not against them but sad to say they are against me because I'm not a believer…Continue
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Posted on October 3, 2011 at 11:33am 13 Comments 1 Like
Masturbation is Abortion says Sen. Enrile | Urban Meter 10/02/2011
The latest RH Bill plenary debate has enlightened millions of Filipinos as the Honorable Senator Juan Ponce Enrile labeled the…Continue
I see PI has an atheist organization now. I have worked in PI for years now, and I know a few atheist there. I missed the convention this summer, but hope to make the next one.
Welcome, Lheins! Glad you could join us. :D
Please consider joining a group to meet people and talk about anything that's on your mind, Hang With Friends.
Hello Lleins Loyola.
Welcome to this freethinker's haven of truth and peace---far from the superstitious world of the god-believing masses.
"If freethinkers could reason with religious people, there would be no religious people."
We invite you to make good friends by joining the busy group "ORIGINS: Universe, Astronomy, Life, Earth, Humans, Religion, Gods, Atheism, Evolution, Darwin..." with 500 discussion topics and 3000 members.
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text:
10 S Calvert St
Baltimore, MD 21202 Downtown Baltimore Rate and review
Baltimore, MD 21202 Downtown Baltimore Rate and review
Oxygen is one of Baltimore's hottest nightclubs featuring state of the art sound systems, VIP table service and multiple bars.
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text:
honeycomb semifreddo
- 3 eggs
- 2 egg yolks, extra
- 1 cup (220g) caster (superfine) sugar
- 1 teaspoon vanilla extract
- 2 cups (500ml) single (pouring) cream
- 100g store-bought honeycomb, chopped
- ice-cream cones, to serve
- Place the eggs, extra yolks, sugar and vanilla in a heatproof bowl over a saucepan of simmering water and, using a hand-held electric mixer, beat for 6–8 minutes or until pale and thick. Remove from the heat and beat for a further 6–8 minutes or until cooled.
- Whisk the cream until soft peaks form. Gently fold the cream through the egg mixture until well combined. Fold through the honeycomb. Pour into a 2 litre-capacity metal tin and freeze for 6 hours or overnight. Spoon into cones to serve. Makes 2 litres.
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text:
|+ view similar properties
|+ view additional features list
This beautifully restored medieval village in Tuscany offers a luxurious range of character filled self-catering cottages that can sleep from 2 to 8 people. The estate has wonderful walks from the doorstep, generous garden grounds, a large swimming pool and a smaller children's pool.
The gardens grounds and terraces are laced with ancient walls, pretty pathways bordered by fragrant Lavender and Rosemary bushes, Wisteria covered pergolas and lots of trees for providing shade on those hot summer days.
The pools (20m x 7m and 7m x 3m) are designed as an adults pool and a children's pool, they sit side by side and are built into a terrace on the hillside. Ample poolside furniture is provided. The pool is heated and usually opened from 1 May to 31 October.
Full of character, the beautifully restored 14th-century village of Borgo di Vagli boasts panoramic views and is idyllically set amongst olive groves, ancient woodlands, fruit trees and vineyards. The village had been left in ruins before a ten-year project was undertaken to completely and authentically restore it. Today, the village maintains, as faithfully as possible, its medieval character and atmosphere with the sympathetic incorporation of modern day comforts.
All of the cottages have been restored with great attention to detail, with wooden beams, stone ceilings and handmade Cotto tiles all complimented by the use of one of the five original Calce plaster colours and rural Tuscan antique furnishings. The houses are brimming full of character and where every cottage is completed to the same high standard, due to the age of the buildings, no two properties are identical.
The Borgo is part of a large geographically protected area and the countryside views take in the 10th century Pierle Castle. The parkland surrounding the property has olive groves, fruit trees, and grassy terraces that offer the privacy to read, relax and dine alfresco. Entirely private and offering a level of authentic country luxury rarely seen in rural Tuscany, the village is comprised of 21 unique properties and includes two swimming pools, a restaurant, and a small shop. The restaurant is located at the base of the 14th-century guard tower, it specialises in traditional Tuscan cuisine using locally sourced products and has a very well-stocked wine cellar.
A car is a necessity and here you are in an ideal position to get out and about to explore both Tuscany and Umbria. Within an easy 20 minute drive is the picturesque town of Cortona and Lake Trasimeno, offering boat trips and various water sports is within an easy drive. Florence, Perugia, Assisi, Siena, Arezzo and Montepulciano are all within easy reach for some great sightseeing opportunities and day trips.
The cottages at Borgo di Vagli are booked based on requirements for one, two or three bedrooms, with the actual accommodation for your stay being allocated about two weeks prior to arrival to take into account any guest's specific requirements, i.e., not having too many steps, suitability for children, etc. On this basis we have provided as many photographs as possible in the 'Gallery' on the Estate Overview page, to allow you to see that all apartments are finished to an equally high standard and each is unique in character and layout.
Enquire About This Property
You can check availabilty and book this property by selecting the 'Prices / Availability' tab above, alternatively, call a member of our team on 01945 430 055 if you would prefer to book this property by phone.


text:
Table of Content
MVAPICH2 is an implementation of the MPI 2.2 Message Passing Interface standard. It is produced by the Network-Based Computing Labortory, Dept of Computer Science and Engineering, The Ohio State University. It is optimized for use over InfiniBand interconnects and related protocols.
Versions and Availability
Softenv Keys for mvapich2 on supermike2
|Softenv Key
▶ Softenv FAQ?
The information here is applicable to LSU HPC and LONI systems.
A user may choose between using /bin/bash and /bin/tcsh. Details about each shell follows.
System resource file: /etc/profile
When one access the shell, the following user files are read in if they exist (in order):
- ~/.bash_profile (anything sent to STDOUT or STDERR will cause things like rsync to break)
- ~/.bashrc (interactive login only)
- ~/.profile
When a user logs out of an interactive session, the file ~/.bash_logout is executed if it exists.
The default value of the environmental variable, PATH, is set automatically using SoftEnv. See below for more information.
The file ~/.cshrc is used to customize the user's environment if his login shell is /bin/tcsh.
SoftEnv is a utility that is supposed to help users manage complex user environments with potentially conflicting application versions and libraries.
System Default Path
When a user logs in, the system /etc/profile or /etc/csh.cshrc (depending on login shell, and mirrored from csm:/cfmroot/etc/profile) calls /usr/local/packages/softenv-1.6.2/bin/use.softenv.sh to set up the default path via the SoftEnv database.
SoftEnv looks for a user's ~/.soft file and updates the variables and paths accordingly.
Viewing Available Packages
The command softenv will provide a list of available packages. The listing will look something like:
$ softenv These are the macros available: * @default These are the keywords explicitly available: +amber-8 Applications: 'Amber', version: 8 Amber is a +apache-ant-1.6.5 Ant, Java based XML make system version: 1.6. +charm-5.9 Applications: 'Charm++', version: 5.9 Charm++ +default this is the default environment...nukes /etc/ +essl-4.2 Libraries: 'ESSL', version: 4.2 ESSL is a sta +gaussian-03 Applications: 'Gaussian', version: 03 Gaussia ... some stuff deleted ...
Managing SoftEnv
The file ~/.soft in the user's home directory is where the different packages are managed. Add the +keyword into your .soft file. For instance, ff one wants to add the Amber Molecular Dynamics package into their environment, the end of the .soft file should look like this:
To update the environment after modifying this file, one simply uses the resoft command:
% resoft
The command soft can be used to manipulate the environment from the command line. It takes the form:
$ soft add/delete +keyword
Using this method of adding or removing keywords requires the user to pay attention to possible order dependencies. That is, best results require the user to remove keywords in the reverse order in which they were added. It is handy to test out individual keys, but can lead to trouble if changing multiple keys. Changing the .soft file and issuing the resoft is the recommended way of dealing with multiple changes.
- Set up your .soft file to select the library version, and the compilers you want to use for building and executing your code. Keep in mind that keys take effect in the order they appear. The following shows how to select and MVAPICH2 library and use it with the GNU gcc compiler. Do not simply copy them, as they are subject to change. Use the softenv command to verify them before use.
- The compiler, mpicc, will use gcc and link with mvapich2 with no further ado.
- Run with:
mpirun_rsh -hostfile $PBS_NODEFILE -np $NPROCS /path/to/executable
- An example PBS script can be viewed below.
+mvapich2-1.4-gcc-4.3.2 +gcc-4.3.2 @default
▶ Open Example?
#!/bin/sh # # No shell commands until PBS setup is completed! # # Before you submit your job, make sure the following are customized # for your particular needs: # # Provide your allocation code. #PBS -A ALLOCATION_CODE # # "workq" is the default job queue. #PBS -q workq # # Set to your email address. #PBS -M EMAIL_ADDRESS # # Queen Bee uses "ppn=8", all others use "ppn=4" #PBS -l nodes=1:ppn=4 # # Set amount of time job may run in hh:mm:ss #PBS -l walltime=00:10:00 # # Have PBS pass all shell variables to the job environment #PBS -V # # Send stdout and stderr to named files. #PBS -o MPI_test.out #PBS -e MPI_test.err # # Give the job a name to make tracking it easier #PBS -N MPI_test # # Shell commands may begin here. # Your executable should either be in your path, or defined explicitly. # Here we'll assume a custom program named "hello" that exists in the # work directory: export EXEC=hello export WORK_DIR=/work/uname/path export NPROCS=`wc -l $PBS_NODEFILE |gawk '//{print $1}'` cd $WORK_DIR # Note that order in which the options appear is important, and the # names may have changed since MVAPICH: mpirun_rsh -np $NPROCS -hostfile $PBS_NODEFILE $WORK_DIR/$EXEC
Last modified: July 27 2019 14:35:54.


text:
KY OEM Short Sleeve Fold Down Collar 3 Button Front Closure Ribbed Cuff man polo t-shirt
Can offer swatchbooks for color option
-Paypal is acceptable for sample
-Trade assurance is acceptable
-On-time Shipment
-100% Product quality protection
-Can change fabric
-Can add your brand label
Printing,Embroidery,Wahing all is welcome
S, M, L, XL, XXL 3XL,4XL,5XL,US size or Euro size all can be customized
Machine Wash Cold,Do Not Bleach,Hang or Ling Dry,Iron with Low Setting
according to designs ,will be full refunded against bulk orders(300 pieces for one color)
7 working days
TT or alibaba Credit insurance payment,L/C
King Young Apparel Company Limited is specialized in manufacturing Tshirts,Hoodies&sweatpants,Shorts,Swimwear,Sportswear,dress,Denim clothings.,
own 1000 square meters Production Workshop,106 Masterful workers,89 Advanced equipment.
Convenient water, land and air transportation / close to Shenzhen,HK,GuangZhou Airport (Port)
our customers from USA,Canada,Australia,Brazil,Sinpapore,Thailand,Vietnam,Malaysia,Sounth Africa,Ireland,Saudi Arabia,Europe Etc
Our company regards "reasonable prices, efficient production time and good sales service" as our tenet. We hope to cooperate with more customers for mutual development and benefits.
1.Are you a manufacturer or trading company? We are the professional garment factory, with 8 years experience in this industry .
2.What is your advantage?Dongguan King Young Apparel Co.,LTD is a professional apparel maker for 6 years experiences,specialized in producing tracksuit,outfits,dress,blouse,T-shirt,Jacket,coat,Pajamas,sports wear(yoga bra,leggings,boxer,caps,hoodies,joggers) , swimwear(bikinis,one piece,trunks),maternity&nursing wear. We have integrated the whole industry chain. We have our own garment factory. High efficient linkage of these mills can afford a completely controled delivery and cost.
3.What is the OEM procedure ? 1) Receive design files ,you can send out your samples too 2) Custom to make samples and ship them to you. 3) Discuss details with you,confirm sample ,deposit paid and begin production.
4.Can you Custom design, logo , size,color,label,packing?
-yes,design,logo ,label,packing all can be customized.
for design,you can send us the JPG,PDF,AI,or hand drawings,we will custom make according to your request
for logo,if you have size,it is better to provide,if no,we will do based on our designer suggestions.
for size,if possible,please provide your model size,so we can make it more fitness.
for color,please contact with our excellent sales,she will send you different color options.
for label,we will send you a computer mockup design,we will make it after you confirmed it.
for packing,you can custom make the hangtag,and print your logo on the polybag.
5.Can I get a free sample?
-dear,because we need buy cloth, print your logo ,sew for you and ship to you.all has cost,so we can not provide free samples.
6.How long is the sample time and mass producing time?
sample making time:7-10 working days+sample delivery time:3-5working days
mass production time:15-25 working days.
7.How much is the product?
the price based on the fabric,logo,order quantity,we will provide accurate price after sample confirmed.
8.Do you have any assurance for the quality?
yes,we can deal on alibaba,and before mass productions,we will make one right sample for you and take photos for you to confirm every details with you avoid any mistakes.
9.Can I get a small order?
dear,it is based on the style and fabric,because cloth supplier has strict MOQ on the cloth too.
10.If I do not like samples,can I change it before mass productions?
yes,of course,tell me any changes you like,and we will modify it according to your request.
11.what product do you sell?
Tshirt,blouse,tank top,swimwear,hoodies,pants,shorts,dress,jacket,tracksuit etc.
12.How to pay?
for sample cost ,you can pay on paypal,wechat or alibaba.
for bulk order,you can pay on paypal,alibaba or our bank account.
13.what is the shipping cost?
we will call different airlines after the goods finished,and get a most economical freight for you.
14.payment terms.
30% or 50% deposit first,before shipment,pay off all the balance.
15.Looking for long terms cooperations!and if you have any questions,please contact with us,we will reply within 1-8 hour.


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@ Richard Bohn
Some would insist that being a 'true' Christian is actually a relationship, not a religion
The Bible is like no other 'religious' book in that those who answer God's call are blessed with the discernment to ferret out what is true or not
Is this in any way in reference to the fact that most Atheists became Atheists, because they actually read the bible? Sounds like they were "blessed with the discernment to ferret out what is true or not."
That's what religions view on religion is. It's what makes me feel sorry for the religious, though religion remains a good start to any persons journey through life as long as they know when to let go of it. I think the problem is that too many people from all groups within the overall group of humanity are prone to following blindly and without question. Some times, people are forced to believe something they don't want to believe in and some times what they refuse to believe in may be partially the right thing to believe in. For, many are those who overlook the good values of religions to state simply their dissatisfaction with those religions.
It becomes a matter of fact that while espousing many bad ideas about how to live life and while horribly spreading hypocrisy through hate while their religion preaches love and undermines its own wordings, those religions themselves; much like any other grouping; are still prone to corruption and deceit as they do remain comprised of earthly men and women who similarly believe in something without true understanding of their own belief.
What I find most common in so many people is a belief in something without the thought structure to reinforce it; including atheists. This leads me to believe that it is the mixture of all stories into a singular narrative; the combining of all things into one; that is the true answer for everything. Only when we all come together in our similarities; for our belief structures for as varied as they seem are massively similar to one another; to disregard our differences will we finally understand and have mass-acceptance of truth and peace and harmony.
One can not fight hate by issuing hate and hate is the division of self and of groupings. Only through love can the combination of selves and groupings maximize their potential and exceed it. Only when the majority are bent toward peace will peace be obtained; as is evidenced strongly by when the majority seeks violence and when does the majority seek violence? When freedom is trampled on and when justice is lost and righteousness fails to fall equally on all people and when peace becomes an impossibility.
Wars become the product of singular individuals who are able to utilize peoples blind faith for their own purposes. Only when people question intensively everything they do and believe in to the point of leaving behind something that remains impossible to deny will they stop having their faith in good things taken advantage of. There is a balance to life and lessons to be learned and those who refuse to learn from those lessons refuse to learn of life and so they come to hate those who do learn those lessons and do learn of life and that brings us to modern society, which isn't so very different than some ancient societies; which only goes to show how much history repeats itself for our benefit. It can only continue on so long until we ultimately destroy ourselves, though.
A war is already here, yet to be fully announced to the public. It remains a war politely fought through politics and non-violence; yet is cruel beyond belief. At any moment, it has the volatility and potential to escalate firmly into a full-on war. It will be the worst one we have ever seen in the history of our kind. And yet, it will breed the greatest time of peace ever known for the survivors. It is not just a war of man against man that we need to be concerned with, but a war against man by nature; a war that man started foolishly as a child argues with a parent when punished fairly for a misdeed.
Imagine no religion; no government; no politics and no drama; imagine a brotherhood of men that all looks out for each other and has true equality and have recognized the responsibility needed to espouse such equality. Personal responsibility, and accountability for ones self and ones actions.
With more and more frequency, people all over the world are entering into higher states of awareness and with each day that passes that we continue to exist in this age of mass-media and information at our fingertips, the more people that are likely to similarly enter into higher states of awareness. This is surely the age that Jesus spoke of and dreamt of all those years ago; not to make christianity the foreground for this post as I view Jesus as just a man largely slandered by the church and immortalized against his will. He wanted people to connect with him and to him and to take his entire life as an example of everything he was saying. I believe he was more like any one of us than a lot of people realize. Just a man and yet a great man all the same.
The answer has always been to understand ourselves; to make fixing ourselves and working on ourselves and bettering ourselves our top priority; for each other. For how can we be strong together if we're not strong on our own and how can we be strong on our own if we're not strong together? And yet, strength is what is given with each failure and mistake, with each persistance and refusal to give up. Spirituality is something that is strongly needed in humanity; it has a truth all its own, though each religions garbled view of it is wrong and its hard for any true atheist to find any concrete answers as to... well, anything.
This teacher, he would destroy in fire those unrepentant fools who persist in harming themselves and others and refuse to change for the better; for what else would he be able to do with them? And this teacher, why would he reward the faithful over those who don't have faith the same as everyone else? If he were a true teacher, would he not praise those that questioned and learned the value of the answer for themselves and learned to have faith in themselves and through that, learned to have faith in him? For whether they know they have faith in him or not, if he is truly a great teacher, then having faith in the answers is more important than having faith in the source of those answers. Faith is what makes us see that all peoples answers are the same answers voiced in different ways; true faith and not false faith which is followed blindly.
That is a pretty creative analogy. I love the cookies and milk for the good little cultists.


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- Latest Industry Standards
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With respect to Tankless Gas Water Heaters in Fredericksburg, VA, you need to be well informed to make the very best choices. We will not inspire you to put together ill advised decisions, as we understand exactly what we're working on, and we make sure you know very well what to expect from the work. You won't face any unexpected surprises when you use Tankless Gas Water Heater Guys. Start out by contacting 888-255-9207 to talk about your job. We'll resolve all your concerns and questions and set up the initial meeting. Our crew can arrive at the scheduled time with all the necessary supplies, and will work together with you during the entire process.
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You will have many good reasons to look to Tankless Gas Water Heater Guys to meet your requirements concerning Tankless Gas Water Heaters in Fredericksburg, VA. We have the greatest customer care ratings, the best supplies, and the most helpful and successful cash saving strategies. We fully understand your preferences and objectives, and we are there to serve you using our practical experience. Dial 888-255-9207 when you need Tankless Gas Water Heaters in Fredericksburg, and we'll work together with you to properly accomplish the project.


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The Fin Brothers, Clark and Bruce, have teamed up once again to fight ocean crime. Follow their progress, brought to you in weekly episodes, as they take on the bad guys and bring them to justice. In Episode 5 they take their message to the people of New Zealand.
13 - 24 of 900 results.


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The number one question asked of our photo lab's customer service representatives is; "When is my order scheduled to ship?" By setting your account up and then logging on to our web site, you will find a complete listing of both your current orders and orders that have shipped within two weeks of your inquiry. Here's a list of information available to you free 24/7 on this site:
All access to your orders and account information, and price catalog is strictly password protected. However, to be included in the data downloading of order information, you must first call customer service and ask to be set up. Have two passwords ready when you call and we will gladly add you to the growing number of H&H customers logging on to this site!
Now it's easier than ever to check your order status! If you carry an iPhone or iPod Touch, you can download the FREE H&H Color Lab iPhone App from the App Store!
Click here for more information.
Download the app from the android market:
Click here for more information.
Log into our web site and fill out the Supplies Order Form. Contact customer service for assistance as needed.
hhstudio breaks jobs into categories when an order is placed. A minimum order is applied to each category. This list shows which products will be grouped together in a single order and the minumum order for each group.


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Bigfoot, Nessie, Ogopogo, the atmospheric jellyfish — (most of) these cryptids are household names. But did you know that there's a subfield of cryptozoology that deals with massive hominids, sequestered on our planet's hidden places? Let's take a look at some curious cases of Brobdingnagians amongst us.
Living dinosaurs and skunk apes have leapfrogged giants on the cryptid taxonomy, but this wasn't always the case. In the 19th century, facsimiles of giants and petrified humans captured the public imagination at sideshows. The most famous of these fakes was the Cardiff Giant, a 10-foot-long, 3,000 pound block of gypsum that was sculpted to look like a fossilized man and was exhibited in upstate New York in late 1869. The Cardiff Giant was the brainchild of tobacconist George Hull, who was inspired by the Nephilim of the Book of Genesis to create his oversized hoax.
Hull staged an excavation and subsequently profited off his giant...until P.T. Barnum covertly built his own replica of the Cardiff giant and displayed his fake (of Hull's fake) as the real deal. Hull attempted to sue Barnum, but in order to do so, he would have to swear on the veracity of his own giant. Hull instead revealed to press that his giant was made of 100% Balonium. Similar "petrified" specimens were unearthed at the tail end of the 1800s, such as the Solid Muldoon, another petrified man, which too was built by Hull.
As the world's various mythologies can attest, giants had a following way before the age of traveling hucksters. In a fascinating article in Archaeology, Mark Rose recounts how an interest in cryptids went hand-in-hand with nascent American life. After all, this was a continent where Southern farmers dug up Basilosaurus fossils to build their homes:
The Massachusetts Puritan Cotton Mather believed that mastodon fossils found near Albany, New York, in 1705 were those of giants who had perished in Noah's flood. "The Giants that once groaned under the waters," he wrote, "are now under the Earth, and their Dead Bones are lively Proofs of the Mosaic history." Nearly a century later, when Connecticut farmer Pliny Moody discovered foot-long three-toed tracks in a sandstone ridge on his land, his pastor identified them as from Noah's raven, which had "rested on that ledge and probably slept there before resuming the dangerous journey back to the Ark." The same cleric later deduced that dinosaur bones found to the south were "probably the remains of giant humans."
Thomas Jefferson had his own interest in fossils, and in 1804 he even set aside a room in the White House for his collection of extinct elephant, giant ground sloth, and bison bones, teeth, and tusks. Earlier, he had convinced Yale College president Ezra Stiles that such remains were of animals rather than giants. Fascinated by an immense claw of a ground sloth, Jefferson wrote to a friend, "I cannot...help believing that this animal, as well as the mammoth, are still existing."
But what about more recent interest in giants? Cryptozoologist (and Cryptomundo blogmaster Loren Coleman) is an expert in the extremely rarified study of "true giants" and details present-day encounters with massive hominids in his book True Giants: Is Gigantopithecus Still Alive? According to Coleman's studies, most modern accounts of giants are of hairy creatures that could be descendants of the 10-foot-tall prehistoric ape Gigantopithecus rather than loincloth-clad chaps of the Fee-Fi-Fo-Fum, Jolly Green, or Samuel Beckett variety.
Modern accounts and possible traces of true giants have come from Tajikistan , Malaysia (where the creature is known as Orang Dalam or Orang Mawas), and the Solomon Islands.
Barring some four-toed footprints, much of this evidence is anecdotal. As fringe as an undiscovered hominid that eclipses Bigfoot sounds, crazier ape-like beings have been spotted — for example, gangs of what appeared to be giant orangutans were observed during the Vietnam War.
[Illustration of Konga from Kill All Monsters]


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It Is All About BTC, LTC, ETH, ZEC mining as well as other alternative crypto currencies
Bitwala is a service that makes bank transfers on your behalf in exchange for bitcoins, so you can use it to pay bills in Euro by spending Bitcoin you own. What is more interesting though it the Bitcoin virtual assistant called LolaBot that the company has just launched and it is dubbed the Siri for Bitcoin. LolaBot is a fun and more personal way to get to know Bitcoin and cryptocurrency in general. Not only are visitors able to ask general questions such as the price of Bitcoin, who invented Bitcoin and so on, visitors interested in getting to know Bitwala can also ask questions about the company, the founders, and even about Lola herself.
Do note that LolaBot requires you to use Chrome, Safari or Chromium browser in order for the full functionality to be available, including the voice recognition feature, using it on other browsers will still work, but you will have to type your questions instead of speaking them. It is more of a fun project at the moment than something very functional and useful, but you might still want to give a try and ask LolaBot some questions regarding Bitcoin or crypto currencies or maybe even about the services that Bitwala offers to its customers.
– For more information about Bitwala's LolaBot project and to try it out yourself…


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Did you hear the one about the new Channel 2 reporter who ended up in the hospital after doing his first on-air report?
The reporter, Danny Spewak, will be hearing about it for the rest of his career.
Spewak, who arrived this week from KOMU in Missouri, was on the Channel 2 set Thursday after doing his first story for the NBC affiliate about the new app the NFTA has to report crimes on its buses or rail system.
News Director Jeff Woodard said that Spewak has not been at the station long enough to get a customized, fitted earpiece so he pulled a spare out of a Channel 2 drawer.
Not a good idea.
After he finished his report, Spewak couldn't get the earpiece out his ear canal. After a few unsuccessful minutes trying to remove it, Spewak was sent to Erie County Medical Center for assistance. Woodard said it took about five minutes at the hospital to get it out.
Spewak had fun on Twitter addressing his embarrassing moment.
"A Cubs player once got hit by a pitch on his first at-bat and didn't play for seven years," wrote Spewak. "I at least had a better first day than him."
Woodard did say Spewak's debut was one for the record books.
"I've been here for 15 years, and this is the best first-day story I have ever heard," said Woodard. "He's fine, no one's hurt, nothing happened on the air. It is a funny story that he'll remember the rest of his career."
Spewak said late Friday afternoon that he's "feeling great."
As to why he headed to Twitter on Thursday night after the incident, Spewak added: "You have to be able to laugh at yourself when something embarrassing happens."
email: firstname.lastname@example.com


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Mets fall short in back-and-forth affair with Nationals
NEW YORK -- The Mets are 7-1 this year with Jon Niese or Matt Harvey on the mound. They are 1-7 with any other starting pitcher. With 10 percent of the season in the books, no statistic better encapsulates this team.
As Niese and Harvey looked on from the dugout bench at Citi Field, Jeremy Hefner and Aaron Laffey combined to allow six runs in 4 2/3 innings Saturday, spoiling the best efforts of a resurgent offense in a 7-6 loss to the Nationals.
"Guys are trying to find their niche, understand roles," third baseman David Wright said. "We'll get better."
Despite Saturday's ineffective starting pitching, the Mets came back to tie the game on John Buck's RBI double off Ryan Mattheus in the seventh. But they lost the lead for good on Bryce Harper's leadoff homer against Josh Edgin in the eighth, falling victim to a player whom Mets manager Terry Collins called "dangerous."
"As I said last year when I saw him for the first time," Collins said, "when this guy's done playing, he's going to set a lot of records."
Thus ended a back-and-forth battle that consumed the middle innings. The Mets managed to knock Nationals starter Gio Gonzalez out of the game after four innings, plating five runs in a rally that prompted Collins to pinch-hit for Hefner. But they gave the lead back half an inning later, when Adam LaRoche greeted Laffey with a three-run homer to left-center.
Laffey faced five batters in relief, retiring two of them and allowing two extra-base hits. A day after Harvey's seven-inning gem, Hefner completed four innings, giving up three runs on four hits and three walks.
"In my mind, I was wanting to go up 2-0 in the series so that we could sweep tomorrow," Hefner said. "Obviously, it didn't work out that way."
Unable to do much of anything early against Gonzalez, the Mets erupted for four hits and three walks in the fourth inning, resulting in five two-out runs. The rally appeared to stall when Wright was caught in a rundown between third and home, but Collin Cowgill broke through with a two-out, two-run single to put the Mets on the board.
Justin Turner, who started at shortstop in place of Ruben Tejada, followed with a two-run single of his own, before Daniel Murphy completed the rally with an RBI hit.
But the Nationals answered half an inning later, when LaRoche tagged Laffey for his three-run homer. Harper's home run was part of a three-hit, two-homer effort for the outfielder, who reached base in all four of his plate appearances. Harper also smacked a two-run shot to right-center field in the third inning, and Ian Desmond tagged Hefner for a solo blast in the second.
The Nationals, in short, outslugged the Mets.
"You get five off Gio, you've got to win that game," Wright said. "I guess you can take some good out of that, but ultimately, we've got to win these types of games. Ultimately, that's something we haven't been very good at this year."
In averaging more than six runs per game early in the season, New York's offense has been downright consistent compared to its pitching, which has ranged from stellar to substandard. Collins chalked his rotation's struggles up to an inconsistent schedule, which included three postponements last week, a delayed doubleheader, a long road trip and freezing temperatures in multiple cities. Hefner, Laffey and third starter Dillon Gee have all pitched on irregular rest as a result, perhaps affecting their consistency.
"We just haven't been able to get our guys in a situation where they're feeling comfortable," Collins said.
The two pitchers who have enjoyed some semblance of a regular schedule, Niese and Harvey, have responded with solid starts to the season. Hardly perfect, Niese has given the Mets at least six innings in three of his four starts, while Harvey has averaged more than seven innings per outing in running his record to 4-0.
Gee, Laffey and Hefner, meanwhile, have averaged just over four innings per outing, crippling the relief corps while digging insurmountable holes for the offense. Even when the bullpen performs admirably, as it did Saturday, five shutout innings is typically too much to ask against one of the National League's most prolific offenses.
So it was at Citi Field, where the Nationals tackled adversity on Saturday better than the Mets. The rubber game looms Sunday, and neither Niese nor Harvey will be pitching.
For the second time this season, the Mets will need to find a way to win regardless.


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Signs of life have re-emerged in New Zealand's manufacturing sector, according to one indicator.
New Zealand manufacturing returned to a minor level of expansion in October, although the sector remained in a flat state, going on the latest BNZ - BusinessNZ Performance of Manufacturing Index (PMI).
The seasonally adjusted PMI for October was 50.5 - up 2 points from September and the first level of expansion after four consecutive months of no expansion. Over the last quarter, the PMI has averaged 48.8, and the year to date at 51.2.
A PMI reading above 50.0 indicates that manufacturing is generally expanding while a drop below 50.0 indicates a decline.
BusinessNZ's executive director for manufacturing Catherine Beard said that any return to expansion was positive news, "but no one should think this is the immediate start of better times ahead for the sector".
"Looking at the history of the survey, we've just come out of the longest consecutive period of contraction since 2009," she said.
On the plus side, an improvement in production and a sharp rise in the number of positive comments by manufacturers are welcome. However, new orders remain historically low, while those employed in manufacturing have been in decline for five consecutive months, she said.
BNZ senior economist Craig Ebert said the October result gave hope that the sector was stabilising after going through a rough patch in recent months.
He said the PMI result was "relief" but that headwinds for the manufacturing still prevail.
"The NZ dollar remains high, international demand is patchy, and the New Zealand economy is looking a bit bumpy and hesitant, including in employment," he said in a statement.
"Until we see a more concerted and consistent pulse in the PMI, we'll stay reticent about the sector's immediate growth prospects," he said.


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DIY Crystal Card Kit: Happy Birthday
Crystal card kits are craft kits, ideal for children and adults, which enable you to make your own sparkly and beautiful crystal cards. The technique is similar to painting by numbers. Each crystal card design has a numbered, adhesive template. Using the amazing magic pencil (included), simply lift up the coloured crystals and place them on the corresponding numbered dots. They affix instantly! The technique is relaxing and therapeutic, and the result is a beautiful piece of rhinestone art which you can gift to loved ones. Crystal card kits are also a great way of making DIY Christmas cards. Making a crystal card takes 30-45 minutes. They are suitable for ages 8 and up.
These new Crystal Cards Kit use the same resin gems as the Crystal Art Kits, giving these cards a subtle shine.
This card is 18 x 18cm in size.
Each crystal card craft set includes:
1 x crystal card template
1 x envelope
1 x magic pencil
1 x tray
Bags of crystals
Zip Lock Bags
The Pedlar's Tray will endeavour to confirm and dispatch your order within 48 hours of receipt. If we foresee any problems in the timely delivery of your goods we will contact you by the fastest assumed means you make available to us at registration. All post will be sent via Royal Mail unless it is a large item, which will be sent via courier service.
The Pedlars Tray will endeavour to confirm and dispatch your order within 48 hours of receipt. If we foresee any problems in the timely delivery of your goods we will contact you by the fastest assumed means you make available to us at registration.
If in the unlikely event that your order arrives damaged, please email us immediately on email@example.com with your contact details or call us on 01432 379095. We will assess the best way to deal with the damaged items and, if required, arrange for a replacement.
While we hope that you are delighted with your order, we understand that due to the limitations of viewing items on the internet they may not be what you had expected and sometimes you will want to return some items ordered through the internet. Please check goods on receipt and call us immediately on 01432 379095 to advise a return together with the reason and to confirm whether you would like to exchange, receive a credit note or refund. Items must be returned to us within 14 days of receipt and, providing goods and their original packaging are in perfect condition, we will arrange the agreed exchange/refund. The parcel and its contents are your responsibility until they reach us. Please wrap the items very securely, giving full details of the action required, and return them to our Brighton store by insured registered delivery and keep the receipt.
The cost of returning goods is at your expense. This does not affect your statutory rights.
Alternatively you may return goods directly to our store. Please note that items bought in the store are not subject to refund unless faulty.
The return address is:
The Pedlars Tray Ltd
Wyevale Hereford Grden Centre
King's Acre Road


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Spokane WA
Spokane, Washington City Page
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Daily exercise is an essential part of a healthy dog's daily schedule. Though many owners may not have time to follow their pet's daily exercise routine, finding a professional dog walker in Spokane is easy withLocalDogWalker.com. Whether you're looking for part time dog walking services, an uptown dog walker or a multiple-dog walker, we can assist you in finding the ideal provider. Each Spokane dog walking business that we contract with is insured and bonded and will offer a variety of dog walks and fitness services to meet your pet's unique needs.
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AtLocalDogWalker.com, we have built a top-notch network of Spokane pet grooming professionals who represent the best in the dog grooming and pet grooming industries. Whether your pet needs more general services such as a shampoo and condition or a cut and blow dry, or more specialized full-service grooming, our contracted Spokane pet grooming companies will leave your pet looking and smelling his best.
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Dog daycare services provide daytime care for dogs, usually while their owners are at work. The staff at a doggie daycare facility will generally provide meals and exercise for your dog, as well as playtime and possibly some grooming. Many of Spokane's best dog daycare centers have contracted withLocalDogWalker.com, allowing us to help you find the perfect local doggie daycare so that you can leave your pet in the morning with confidence.
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amdgpu is the open source graphics driver for the latest AMD Radeon graphics cards.
- 1 Selecting the right driver
- 2 Installation
- 3 Loading
- 4 Xorg configuration
- 5 Features
- 6 Troubleshooting
Selecting the right driver
Depending on the card you have, find the right driver in Xorg#AMD. This page has instructions for AMDGPU and AMDGPU PRO.
At the moment there is support for Volcanic Islands (VI) (and newer) and experimental support for Sea Islands (CI) and Southern Islands (SI) cards. AMD has no plans to support pre-GCN GPUs.
Owners of unsupported GPUs may use the open source radeon or the AMD Catalyst driver instead.
Install the mesa package, which provides the DRI driver for 3D acceleration.
- For 32-bit application support, also install the lib32-mesa package from the multilib repostory.
- For the DDX driver (which provides 2D acceleration in Xorg), install the xf86-video-amdgpu package.
- For Vulkan support, install the vulkan-radeon package. Optionally install the lib32-vulkan-radeon package for 32-bit application support.
Support for accelerated video decoding is provided by libva-mesa-driver and lib32-libva-mesa-driver for VA-API and mesa-vdpau and lib32-mesa-vdpau packages for VDPAU.
Enable Southern Islands (SI) and Sea Islands (CIK) support
The linux package enables AMDGPU support for cards of the Southern Islands (SI) and Sea Islands (CIK). When building or compiling a kernel,
CONFIG_DRM_AMDGPU_SI=Y and/or
CONFIG_DRM_AMDGPU_CIK=Y should be be set in the config.
Even when AMDGPU support for SI/CIK has been enabled by the kernel, the radeon driver may be used instead of the AMDGPU driver.
To make sure the
amdgpu is loaded first use the following Mkinitcpio#MODULES array, e.g.
MODULES=(amdgpu radeon).
Set required module parameters
To enable full support for SI/CIK when using the
amdgpu, set the following kernel parameters to prevent the
radeon module from being used [1]:
$ dmesg
[..] amdgpu 0000:01:00.0: CIK support provided by radeon. [..] amdgpu 0000:01:00.0: Use radeon.cik_support=0 amdgpu.cik_support=1 to override.
The flags depend on the cards GCN version:
- Southern Islands (SI):
radeon.si_support=0 amdgpu.si_support=1
- Sea Islands (CIK):
radeon.cik_support=0 amdgpu.cik_support=1
AMD DC (display code), introduced in linux 4.15-4.17, is a new display stack that brings support for atomic mode-setting and HDMI/DP audio. For more info about AMDGPU-DC, see this article.
If you are on GCN 1.1 or newer with AMDGPU and want to use DC, set
amdgpu.dc=1 as kernel parameter or module option when using KMS.
- To use the proprietary OpenCL component without AMDGPU PRO, install opencl-amdAUR instead.
- A downgrade of the linux (4.9) and Xorg (1.18) packages is required to use AMDGPU PRO 17.10.
AMD provides a proprietary, binary userland driver called AMDGPU PRO, which works on top of the open-source AMDGPU kernel driver. The driver provides OpenGL, OpenCL, Vulkan, VA-API and VDPAU support (although this is also supported by the open-source driver). For some workloads it provides better performance than the open-source driver (example benchmark), while for others the contrary is true (example benchmark).
See the release notes and the announcement at the Phoronix forum for more information.
A patched version of the official AMDGPU PRO driver is available as amdgpu-proAUR in AUR.
amdgpu kernel module should load fine automatically on system boot.
If it does not happen, then:
- Make sure to #Enable Southern Islands (SI) and Sea Islands (CIK) support when needed.
- Make sure you have the latest linux-firmware package installed. This driver requires the latest firmware for each model to successfully boot.
- Make sure you do not have
vga=as a kernel parameter, since
amdgpurequires KMS.
- Check that you have not disabled
amdgpuby using any kernel module blacklisting.
Enable early KMS
Kernel mode setting (KMS) is supported by the amdgpu driver, is mandatory and enabled by default.
KMS is typically initialized after the initramfs stage. It is possible, however, to enable KMS during the initramfs stage. To do this, add the
amdgpu module to the
MODULES line in
MODULES=(amdgpu radeon)
Now, regenerate the initramfs:
# mkinitcpio -p linux
The change takes effect at the next reboot.
Xorg configuration
Xorg will automatically load the driver and it will use your monitor's EDID to set the native resolution. Configuration is only required for tuning the driver.
If you want manual configuration, create
/etc/X11/xorg.conf.d/20-amdgpu.conf, and add the following:
Section "Device" Identifier "AMD" Driver "amdgpu" EndSection
Using this section, you can enable features and tweak the driver settings, see amdgpu(4) first before setting driver options.
Tear Free Rendering
TearFree controls tearing prevention using the hardware page flipping mechanism. If this option is set, the default value of the property is 'on' or 'off' accordingly. If this option isn't set, the default value of the property is auto, which means that TearFree is on for rotated outputs, outputs with RandR transforms applied and for RandR 1.4 slave outputs, otherwise off:
Option "TearFree" "true"
DRI level
DRI sets the maximum level of DRI to enable. Valid values are 2 for DRI2 or 3 for DRI3. The default is 3 for DRI3 if the Xorg version is >= 1.18.3, otherwise DRI2 is used:
Option "DRI" "3"
Video acceleration
See Hardware video acceleration.
Since Linux 4.17, it is possible to adjust clocks and voltages of the graphics card via
/sys/class/drm/card0/device/pp_od_clk_voltage. It is however required to unlock access to it in sysfs by appending the boot parameter
After this, the range of allowed values must be increased to allow higher clocks than used by default. To allow the maximum GPU clock to be increased by e.g. up to 2%, run:
echo "2" > /sys/class/drm/card0/device/pp_sclk_od
/sys/class/drm/card0/device/pp_sclk_od does always return either 1 or 0, no matter the value added to it via
Unlike with previous kernel versions, this alone doesn't lead to a higher clock. The values in
pp_od_clk_voltage for the pstates have to be adjusted as well. It's a good idea to get the default values as a guidance by simply reading the file. In this example, the default clock is 1196MHz and a range increase by 2% allows up to 1219MHz.
To set the GPU clock for the maximum pstate 7 on a Polaris GPU to 1209MHz and 900mV voltage, run:
# echo "s 7 1209 900" > /sys/class/drm/card0/device/pp_od_clk_voltage
The same procedure can be applied to VRAM pstates, e.g.:
# echo "m 2 1850 850" > /sys/class/drm/card0/device/pp_od_clk_voltage
To apply, run
# echo "c" > /sys/class/drm/card0/device/pp_od_clk_voltage
To check if it worked out, read out clocks and voltage under 3D load:
# watch -n 0.5 cat /sys/kernel/debug/dri/0/amdgpu_pm_info
You can reset to the default values using this:
# echo "r" > /sys/class/drm/card0/device/pp_od_clk_voltage
It is also possible to forbid the driver so switch to certain pstates, e.g. to workaround problems with deep powersaving pstates like flickering artifacts or stutter. To force the highest VRAM pstate on a Polaris RX 5xx card, while still allowing the GPU itself to run with lower clocks, run:
# echo "manual" > /sys/class/drm/card0/device/power_dpm_force_performance_level # echo "2" > /sys/class/drm/card0/device/pp_dpm_mclk
Allow only the three highest GPU pstates:
# echo "5 6 7" > /sys/class/drm/card0/device/pp_dpm_sclk
To set the allowed maximum power consumption of the GPU to e.g. 50 Watts, run
# echo 50000000 > /sys/class/drm/card0/device/hwmon/hwmon0/power1_cap
Until Linux kernel 4.21/5.1, it will only be possible to decrease the value, not increase.
Enable GPU display scaling
To avoid the usage of the scaler which is built in the display, and use the GPU own scaler instead, when not using the native resolution of the monitor, execute:
$ xrandr --output "<output>" --set "scaling mode" "<scaling mode>"
Possible values for
"scaling mode" are:
None, Full, Center, Full aspect
- To show the available outputs and settings, execute:
$ xrandr --prop
- To set
scaling mode = Full aspectfor just every available output, execute:
$ for output in $(xrandr --prop | grep -E -o -i "^[A-Z\-]+-[0-9]+"); do xrandr --output "$output" --set "scaling mode" "Full aspect"; done
Xorg or applications won't start
- "(EE) AMDGPU(0): [DRI2] DRI2SwapBuffers: drawable has no back or front?" error after opening glxgears, can open Xorg server but OpenGL apps crash.
- "(EE) AMDGPU(0): Given depth (32) is not supported by amdgpu driver" error, Xorg won't start.
Setting the screen's depth under Xorg to 16 or 32 will cause problems/crash. To avoid that, you should use a standard screen depth of 24 by adding this to your "screen" section:
Section "Screen" Identifier "Screen" DefaultDepth 24 SubSection "Display" Depth 24 EndSubSection EndSection
Screen artifacts and frequency problem
Dynamic power management may cause screen artifacts to appear when displaying to monitors at higher frequencies (120+Hz) due to issues in the way GPU clock speeds are managed[2][3].
A workaround [4] is saving
high or
low in
There is also a GUI solution [5] where you can manage the "power_dpm" with radeon-profile-gitAUR and radeon-profile-daemon-gitAUR.
Screen flickering
If you experience flickering [6] add
amdgpu.dc=0 to your kernel parameters.
R9 390 series Poor Performance and/or Instability
If you experience issues [7] with a AMD R9 390 series graphics card, set
radeon.cik_support=0 amdgpu.cik_support=1 amdgpu.dpm=1 amdgpu.dc=1 as kernel parameters to force DPM support.
Freezes with "[drm] IP block:gmc_v8_0 is hung!" kernel error
If you experience freezes and kernel crashes during a GPU intensive task with the kernel error " [drm] IP block:gmc_v8_0 is hung!" [8], a workaround is to set
amggpu.vm_update_mode=3 as kernel parameters to force the GPUVM page tables update to be done using the CPU. Downsides are listed here [9].


text:
- Sales Home
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Prairie Homestead Self-Guided Tour
Audience: Family (all ages)
Presented and Managed by the City of Aurora
Join us at the Plains Conservation Center for a self-guided tour of our historical sod village and tipis. See what a Native American tipi camp might have looked like in the early 1800s. Immerse yourself in a replication of an 1880s prairie homestead village with authentic artifacts and, depending on the season, real farm animals.
Please Note: All guests must check in at the PCC Visitor Center with purchase confirmation prior to beginning self-guided tour in order to receive site condition updates and the actual self-guided brochure.
For a more in-depth experience, sign up for a guided tour or program! Join us for a "Plains Conservation Center Wagon Tour" on a Saturday or schedule a private tour by contacting Denver Botanic Gardens at email@example.com or 720-865-3500.
The City of Aurora's Parks, Recreation & Open Space department's mission is to encourage active lifestyles and create healthy environments for people, nature and community.
Location: Plains Conservation Center, 21901 E. Hampden Avenue, Aurora, CO 80013
Hours for Self-Guided Tours:
Monday-Tuesday: Closed
Wednesday-Friday: 1:30 p.m. - 4 p.m.
Saturday-Sunday: 9 a.m. - 4 p.m.


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Our full-service hotel features 213 newly-renovated guest rooms and suites and over 40,000 square feet of flexible meeting space. You'll find world-class personalized service at our refreshingly local yet sophisticated Ramada Topeka Downtown.
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- 213 Newly Renovated Hotel Rooms
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- Holley Museum of Military History
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Work In Progress Construction updates.
» More student housing is underway
CCU broke ground Jan 24 on an $85 million residence facility that will house 1,270 freshman students.
The four-building facility marks a new direction in student living, with residence halls arranged in "communities" of four suites grouped around a common social space. Each building will have its own community wing with a lounge, laundry, an office/apartment for the resident director, workrooms and a recycling center. The main building, or "head house," will offer conference rooms, a convenience store, kitchen and other multipurpose spaces.
Debbie Conner, vice president of Student Affairs at CCU, describes the project as "state-of-the-art living communities that will be tied to the overall student learning experience."
Designed by Quackenbush Architects and Planners, the buildings will be constructed in three phases. The first two buildings are expected to be ready for occupancy in the summer of 2015, and the entire project will be finished in 2016. The architectural design of the complex will compliment the traditional Southern classical style of the campus. The placement of the buildings on the site will allow for the development of a large green space that will accommodate two existing ponds and a stand of mature oak and maple trees. The structures will be designed to meet Leadership in Energy and Environmental Design (LEED) standards for sustainability.
"The increase in our bed inventory means we are built for growth, and we will be able to introduce many new aspects to our University Housing offerings," said Stephen Harrison, director of University Housing. "University Housing seeks to create a foundation of care for resident safety and success, and today's groundbreaking ceremony marks a huge leap forward in our efforts to make that vision a reality."
The groundbreakers at the ceremony, all wielding teal shovels, were CCU President David DeCenzo; Board of Trustees Chairman Wyatt Henderson; Provost Ralph Byington; Debbie Conner; Stephen Harrison; Harry Titus, student president of CCU's Residence Hall Association; Shawn Godwin, CCU project manager; architect Doug Quackenbush; and Ryan Reynolds of HG Reynolds, building contractor.


text:
Changes related to "Standard approaches to obtaining a Maintenance Contract ... and the problems that result"
From CCTV Information
This is a list of changes made recently to pages linked from a specified page (or to members of a specified category). Pages on your watchlist are bold.
No changes during the given period matching these criteria.


text:
The Chargers needed change in some areas.
April attendance isn't one of them.
On Monday morning, players begin a nine-week offseason workout program that is divided between three phases, and as usual, a high turnout is expected. The roughly 50 veterans will be one of few familiar sights at Chargers Park, however, as the new-look team facility runs its workout schedule at a new time.
The next two weeks, called "Phase One," begin early.
San Diego is among eight NFL teams to start structured training this week, a two-week head start on the rest of the league. It's a collectively bargained allowance for those who replaced a head coach since the end of last season.
They also receive an extra veteran minicamp.
For the Chargers, that runs April 16 to 18. Attendance, again, is optional.
"The coordinators and I have already outlined the voluntary minicamp, so we've gone through all that," coach Mike McCoy said at last month's annual league meeting. "We've said, 'Here's what we're going to run in practice.' … We've got a good idea of what we want to emphasize — the coaching points — and really build the foundation."
For now, the football coaches can't do much with players.
They can't join them in the weight room, which has been redesigned with new equipment. They can't join them on the practice field, which was been fully resodded. From a distance, they can't so much as observe.
The two weeks are purposed for strength and conditioning and physical rehabilitation.
For a variety of reasons, attendance to them is typically very high.
Many players live local. Workouts informally are viewed as a chance to build chemistry and set a positive first impression, be it with staff members or teammates. It's an opportunity to meet some of the new free agents; there are eight first-time Chargers players that have been signed since Feb. 20.
Strength and conditioning coach Kent Johnston and assistant Rick Lyle also are both new. They spent the past three years in Cleveland.
One incentive is financial.
Each player will earn $175 for a day of attendance. Last year, players made as much as $4,960 for offseason training, a rate of $155 per session.
Phase One workouts, closed to the media and public, entail little activity directly related to football.
There are no helmets or pads. For the most part, there are no footballs.
The exception is quarterbacks Philip Rivers and Charlie Whitehurst can throw passes to receivers as long as no player is attempting to cover them.
OTAs run from May 13 to 15, May 20 to 22 and June 3 to 6.
Mandatory minicamp is on June 11 to 13.


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Individual differences |
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Clinical: Approaches · Group therapy · Techniques · Types of problem · Areas of specialism · Taxonomies · Therapeutic issues · Modes of delivery · Model translation project · Personal experiences ·
Familial Alzheimer's disease (FAD) is an uncommon form of Alzheimer's disease that comes on earlier in life (usually between 30 and 60 years of age) and is inherited in an autosomal dominant fashion. While it only accounts for 5% or less of total Alzheimer's disease, it has presented a useful model in studying various aspects of the disorder.
Clinical featuresEdit
Alzheimer disease (AD) is the most common form of dementia. It usually occurs in old age, and starts gradually with early signs being forgetfulness, particularly in remembering recent events and the names of people and things. There may be some other cognitive difficulties early on, but nothing overly alarming.
As the disease progresses, the patient may start to exhibit greater problems. They may forget how to do simple things such as brushing their hair, and later in the disease may become anxious or aggressive, ultimately needing full-time care.
Familial Alzheimer disease is an uncommon form of Alzheimer's that comes on earlier in life (usually between 30 and 60 years) and is inherited in an autosomal dominant fashion. There are a number of types of familial (or early-onset) AD, which are identified by their genetics and other characteristics such as the age of onset. As a whole, this form of the disease only accounts for roughly 10% to 15% of all cases of AD.
Histologically, familial AD is practically indistinguishable from other forms of the disease. Deposits of amyloid can be seen in sections brain tissue (visible as an apple-green yellow birefringence under polarised light). This amyloid protein forms plaques and neurofibrillary tangles that progress through the memory centres of the brain. Very rarely the plaque may be unique, or uncharacteristic of AD; this can happen when there is a mutation in one of the genes that creates a functional, but malformed, protein instead of the ineffective gene products that usually result from mutations.
Genetic causes and mutationsEdit
There are multiple genetic causes of Alzheimer disease. Two of these are the presenilin polymorphisms on chromosomes 1 and 14, Others include several amyloid precursor protein polymorphisms and one of the four common alleles of apolipoprotein E. Several other gene polymorphisms have also been identified to increase susceptibility to Alzheimer's.
PSEN1 - Presenilin 1Edit
The presenilin 1 gene (PSEN1) was linked to the long arm of chromosome 14 (14q24.3) using a pedigree of 34 people suffering from early-onset Alzheimer disease by Campion (1995). The actual gene was identified by Sherrington (1995) to be PSEN1, and multiple mutations were identified. Mutations in this gene cause familial Alzheimer's type 3. This protein has been identified as part of the enzymatic complex that cleaves amyloid beta peptide from APP (see below).
The gene contains 14 exons, and the coding portion is estimated at 60 kb, as reported by Rogaev (1997) and Del-Favero (1999). The protein the gene codes for (PS1) is an integral membrane protein. As stated by Ikeuchi (2002) it cleaves the protein Notch1 so is thought by Koizumi (2001) to have a role in somitogenesis in the embryo. It also has an action on an amyloid precursor protein, which gives its probable role in the pathogenesis of FAD. Homologs of PS1 have been found in plants, invertebrates and other vertebrates.
There are many allelic variants in PSEN1 that cause AD including Met146Leu which has been found in unrelated families in Italy by Sherrington (1995), and in Argentina by Morelli (1998). There are other mutations at this same amino acid position including Met146Val, found by the Alzheimer's Disease Collaborative Group (1995), and Met146Ile identified as two different point mutations, one in a Danish family by Jorgensen (1996), and another in a Swedish family by Gustafson (1998).
Some of the mutations in the gene, of which there are over 90, include: His163Arg, Ala246Glu, Leu286Val and Cys410Tyr. Most display complete penetrance, but a common mutation is Glu318Gly and this predisposes individuals to familial Alzheimer disease, with a study by Taddei (2002) finding an incidence of 8.7% in patients with familial AD.
PSEN2 - Presenilin 2Edit
The presenilin 2 gene (PSEN2) is very similar in structure and function to PSEN1. It is located on chromosome 1 (1q31-q42), and variants of this gene cause type 4 FAD. A study by Kovacs (1996) showed that PS1 and PS2 proteins are expressed in similar amounts, and in the same organelles as each other, in mammalian neuronal cells. Levy-Lahad (1996) determined that PSEN2 contained 12 exons, 10 of which were coding exons, and that the primary transcript encodes a 448 amino acid polypeptide with 67% homology to PS1. This protein has been identified as part of the enzymatic complex that cleaves amyloid beta peptide from APP (see below).
The mutations have not been studied as much as PSEN1, but distinct allelic variants have been identified. These include Asn141Ile, which has been identified by many studies in Volga German families with familial Alzheimer disease. One of these studies by Nochlin (1998) found severe amyloid angiopathy in the affected individuals in a family. This phenotype may be explained by a study by Tomita (1997) suggesting that the Asn141Ile mutation alters amyloid precursor protein (APP) metabolism causing an increased rate of protein deposition into plaques.
Other allelic variants are Met239Val which was identified in an Italian pedigree by Rogaev (1995) who also suggested early on that the gene may be similar to PSEN1, and a Asp439Ala mutation in exon 12 of the gene which is suggest by Lleo (2001) to change the endoproteolytic processing of the PS2.
APP – Amyloid beta (A4) precursor proteinEdit
Mutations to the amyloid beta A4 precursor protein (APP) located on the long arm of chromosome 21 (21q21.3) can also cause familial Alzheimer disease (type 1) as well as other problems. The different mutations have different ages of onset.
Research done by Yoshikai (1990) found that the multiple isoforms of this protein were caused by alternative splicing of the 19-exon gene.
APP is cleaved by gamma-secretase integral membrane proteins such as PS1 and PS2 discussed above.
Allelic variants of APP that cause Alzheimer disease include three mutations from a valine at position 717 to isoleucine, phenylalanine or glycine.
In addition, a form of FAD has been discovered that has no mutation in the APP protein but a mutation in the APP promoter region.
APOE - Apolipoprotein EEdit
The APOE gene codes for an apolipoprotein, so is involved with the transport of lipids around the body. Its role in the cause of Alzheimer disease is not an autosomal dominant effect as with the previous three genes; some variants may cause a slight predisposition to AD (Corder, 1993), and Amouyel (1994) reported an increased the risk of other neurological disorders such as Creutzfeldt-Jakob disease.
The variant discussed by Corder (1993) was apolipoprotein E type 4 (ApoEε4) - the greater the number of copies of this allele a person possessed, the greater their chance of developing Alzheimer disease. This gene lies on chromosome 19 (its locus is 19q13.2), and the subgroup of FAD it causes is type 2.
Other mutations summaryEdit
There is considerable genetic heterogeneity in familial Alzheimer disease, and obvious genetic causes of Alzheimer's account for a small proportion of the disease. With each gene, there are usually many different mutant alleles that are capable of causing the problem.
Clinically there is rarely any correlation of the disease phenotype with the genotype, though there may be biochemical and histological tests where a difference can be picked up.
The types of FAD include type 1, caused by APP mutation; type 2, the susceptibility to which is increased with APOE*E4; and type 3 and type 4 caused by PSEN1 and PSEN2 mutations respectively. The PSEN and the APP mutations show autosomal dominant inheritance. As well as these there are other types including a mitochondrial DNA association identified by Lin (1992), and an association of a variant of alpha 2-macroglobulin with FAD reported by Liao (1998) (although later studies have not been able to reproduce this). Zubenko (2001) showed Alzheimer disease type 7 is associated with a gene (D10S1423) whose locus is 10p3. Olson (2002) found a locus for late-onset Alzheimer disease (type 8) on the short arm of chromosome 20. Many of these genes affect APP (which is not surprising given the pathology of Alzheimer disease), and there are other lipoprotein associations apart from Apolipoprotein E.
See alsoEdit
References & BibliographyEdit
- Alzheimer's Disease Collaborative Group (1995), The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families. Nature Genetics, vol. 11, pp. 219-222.
- Amouyel, P., Vidal, O., Launay, J. M., Laplanche, J. L. (1994), The apolipoprotein E alleles as major susceptibility factors for Creutzfeldt-Jakob disease. Lancet, vol. 344, pp. 1315-1318.
- Campion, D., Brice, A., Hannequin, D., Tardieu, S., Dubois, B., Calenda, A., Brun, E., Penet, C., Tayot, J., Martinez, M., et al. (1995), A large pedigree with early-onset Alzheimer's disease: clinical, neuropathologic, and genetic characterization. Neurology, vol. 45, no. 1, pp. 80-85.
- Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., Pericak-Vance, M. A. (1993), Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science, vol. 261, pp. 921-923.
- Del-Favero, J., Goossens, D., Van den Bossche, D., Van Broeckhoven, C. (1999), YAC fragmentation with repetitive and single-copy sequences: detailed physical mapping of the presenilin 1 gene on chromosome 14. Gene, vol. 229, no. 1-2, pp. 193-201.
- Gustafson, L., Brun, A., Englund, E., Hagnell, O., Nilsson, K., Stensmyr, M., Ohlin, A. K., Abrahamson, M. (1998), A 50-year perspective of a family with chromosome-14-linked Alzheimer's disease. Human Genetics, vol. 102, pp. 253-257.
- Levy-Lahad, E., Poorkaj, P., Wang, K., Fu, Y. H., Oshima, J., Mulligan, J., Schellenberg, G. D. (1996),Genomic structure and expression of STM2, the chromosome 1 familial Alzheimer disease gene. Genomics, vol. 34, pp. 198-204.
- Liao, A., Nitsch, R. M., Greenberg, S. M., Finckh, U., Blacker, D., Albert, M., Rebeck, G. W., Gomez-Isla, T., Clatworthy, A., Binetti, G., Hock, C., Mueller-Thomsen, T., Mann, U., Zuchowski, K., Beisiegel, U., Staehelin, H., Growdon, J. H., Tanzi, R. E., Hyman, B. T. (1998), Genetic association of an alpha-2-macroglobulin (val1000ile) polymorphism and Alzheimer's disease. Human Molecular Genetics, vol. 7, pp. 1953-1956.
- Lin, F. H., Lin, R., Wisniewski, H. M., Hwang, Y.-W., Grundke-Iqbal, I., Healy-Louie, G., Iqbal, K. (1992), Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in Alzheimer's brains. Biochemical & Biophysical Research Communications, vol. 182, pp. 238-246.
- Lleo, A., Blesa, R., Gendre, J., Castellvi, M., Pastor, P., Queralt, R., Oliva, R. (2001), A novel presenilin 2 gene mutation (D439A) in a patient with early-onset Alzheimer's disease. Neurology, vol. 57, pp. 1926-1928.
- Jorgensen, P., Bus, C., Pallisgaard, N., Bryder, M., Jorgensen, A. L. (1996), Familial Alzheimer's disease co-segregates with a met146ile substitution in presenilin-1. Clinical Genetics, vol. 50, pp. 281-286.
- Kovacs, D. M., Fausett, H. J., Page, K. J., Kim, T.-W., Moir, R. D., Merriam, D. E., Hollister, R. D., Hallmark, O. G., Mancini, R., Felsenstein, K. M., Hyman, B. T., Tanzi, R. E., Wasco, W. (1996), Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nature Medicine, vol. 2, pp. 224-229.
- Ikeuchi, T., Sisodia, S. S. (2002), Cell-free generation of the notch1 intracellular domain (NICD) and APP-CTfgamma: evidence for distinct intramembranous "gamma-secretase" activities. Neuromolecular Medicine, vol. 1, no. 1, pp. 43-54.
- Koizumi, K., Nakajima, M., Yuasa, S., Saga, Y., Sakai, T., Kuriyama, T., Shirasawa, T., Koseki, H. (2001), The role of presenilin 1 during somite segmentation. Development, vol. 128, no. 8, pp. 1391-402.
- Morelli, L., Prat, M. I., Levy, E., Mangone, C. A., Castano, E. M. (1998), Presenilin 1 met146leu variant due to an A-T transversion in an early-onset familial Alzheimer's disease pedigree from Argentina. Genetics, vol. 53, pp. 469-473.
- Olson, J. M., Goddard, K. A. B., Dudek, D. M. (2002), A second locus for very-late-onset Alzheimer disease: a genome scan reveals linkage to 20p and epistasis between 20p and the amyloid precursor protein region. American Journal of Human Genetics, vol. 71, pp. 154-161.
- Rogaev, E. I., Sherrington, R., Rogaeva, E. A., Levesque, G., Ikeda, M., Liang, Y., Chi, H., Lin, C., Holman, K., Tsuda, T., Mar, L., Sorbi, S., Nacmias, B., Placentini, S., Amaducci, L., Chumakov, I., Cohen, D., Lannfelt, L., Fraser, P. E., Rommens, J. M., St George-Hyslop, P. H. (1995), Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature, vol. 376, pp. 775-778.
- Rogaev, E. I., Sherrington, R., Wu, C., Levesque, G., Liang, Y., Rogaeva, E. A., Ikeda, M., Holman, K., Lin, C., Lukiw, W. J., de Jong, P. J., Fraser, P. E., Rommens, J. M., St. George-Hyslop, P. (1997), Analysis of the 5-prime sequence, genomic structure, and alternative splicing of the presenilin-1 gene (PSEN1) associated with early onset Alzheimer disease. Genomics, vol. 40, pp. 415-424.
- Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., Tsuda, T., Mar, L., Foncin, J. F., Bruni, A. C., Montesi, M. P., Sorbi, S., Rainero, I., Pinessi, L., Nee, L., Chumakov, I., Pollen, D., Brookes, A., Sanseau, P., Polinsky, R. J., Wasco, W., Da Silva, H. A. R., Haines, J. L., Pericak-Vance, M. A., Tanzi, R. E., Roses, A. D., Fraser, P. E., Rommens, J. M., St George-Hyslop, P. H. (1995), Cloning of a gene bearing mis-sense mutations in early-onset familial Alzheimer's disease. Nature, vol. 375, pp. 754-760.
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- History
- The symptoms of the disease as a distinct nosologic entity were first identified by Emil Kraepelin, and the characteristic neuropathology was first observed by Alois Alzheimer in 1906. In this sense, the disease was co-discovered by Kraepelin and Alzheimer, who worked in Kraepelin's laboratory. Because of the overwhelming importance Kraepelin attached to finding the neuropathological basis of psychiatric disorders, Kraepelin made the generous decision that the disease would bear Alzheimer's name (J. Psychiat. Res., 1997, Vol 31, No. 6, pp. 635-643).
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