text:
Participating Organization(s)
National Institutes of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Funding Opportunity Title
Epigenetic Inheritance and Transgenerational Effects of Alcohol (R01)
Activity Code
R01 Research Project Grant
Announcement Type
Related Notices
Funding Opportunity Announcement (FOA) Number
Companion Funding Opportunity
Catalog of Federal Domestic Assistance (CFDA) Number(s)
Funding Opportunity Purpose
This Funding Opportunity Announcement (FOA), issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), encourages Research Project Grant (R01) applications proposing to conduct mechanistic studies in humans and animal models on alcohol-induced transgenerational effects and the role of epigenetic inheritance in these effects.
Posted Date
October 3, 2012
Open Date (Earliest Submission Date)
January 5, 2013
Letter of Intent Due Date
Not Applicable
Application Due Date(s)
Standard dates apply, by 5:00 PM local time of applicant organization.
AIDS Application Due Date(s)
Standard dates apply, by 5:00 PM local time of applicant organization.
Scientific Merit Review
Standard dates apply
Advisory Council Review
Standard dates apply
Earliest Start Date(s)
Standard dates apply
Expiration Date
May 8, 2016
Due Dates for E.O. 12372
Not Applicable
Required Application Instructions
It is critical that applicants follow the instructions in the SF 424 (R&R) Application Guide, except where instructed to do otherwise (in this FOA or in a Notice from the NIH Guide for Grants and Contracts). Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.
Part 1. Overview Information
Part 2. Full Text of the Announcement
Section I. Funding Opportunity Description
Section II. Award Information
Section III. Eligibility Information
Section IV. Application and Submission Information
Section V. Application Review Information
Section VI. Award Administration Information
Section VII. Agency Contacts
Section VIII. Other Information
This Funding Opportunity Announcement (FOA), issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), encourages Research Project Grant (R01) applications proposing to conduct studies on alcohol-induced transgenerational effects and the role of epigenetic inheritance in these effects. There is growing evidence that the DNA sequence alone is not the sole source of information transfer across generations leading to phenotypic diversity. Chemical modifications of DNA and chromatin as well as non-coding RNAs are critical molecular processes that regulate gene expression and are grouped under the rubric of epigenetics. The maintenance of these epigenetic marks are critical for normal somatic function, but are generally thought to be cleared in germ cells which allows for totipotency. The main premise of this FOA is that some epigenetic marks are not cleared in germ cells and serve as an ancestral 'memory' of environmental exposure. More specifically, epigenetic inheritance can result when these marks are not cleared in germ cells and thus can be passed from one generation to the next contributing to phenotypic diversity. Diet, environmental toxicants, and stress have been shown to alter epigenetic marks with evidence that these environmental 'exposures' can cause transgenerational phenotypes which may involve epigenetic inheritance. The involvement of epigenetic inheritance in the transgenerational effects of alcohol is not well studied but could lead to significant advances in our understanding of vulnerability to alcohol use disorders. The effects of in utero alcohol exposure are well documented in the exposed generation and lead to Fetal Alcohol Syndrome (FAS) and Fetal Alcohol Spectrum Disorder (FASD). However, if the deleterious effects of in utero alcohol exposure are transmitted epigenetically to unexposed offspring is not well studied. In addition, the effects of chronic alcohol exposure in male and female parents prior to conception could result in transgenerational phenotypes that are transmitted epigenetically. Both studies examining the effects of in utero alcohol exposure as well as chronic alcohol exposure of male and female parents prior to conception are encouraged.
Complex traits are the result of multiple genetic and environmental factors which interact over the lifespan and typically do not follow a simple Mendelian mode of inheritance. The non-Mendelian inheritance pattern is thought to be the result of the collective effects of several to hundreds of genes that individually do not have a large effect on the phenotype. The results of Genome-Wide Association studies (GWAS) have generally supported this notion: many common variants of small effect have been identified for complex traits and diseases. However, a perplexing situation has arisen because the variants identified by GWAS have not been able to account for all of the estimated heritability of the traits under study, leading to the 'missing heritability' problem. There have been several explanations presented to explain the missing heritability, some of which include: undetected rare variants of large effect, epistatic interactions, and the idea that heritability estimates may actually be over-inflated. Implicit in these explanations is that inheritance is determined at the level of the DNA sequence and this idea is a well-established and accepted principle of modern genetics. There is, however, increasing evidence that the DNA sequence alone is not the sole source of information transfer between generations that affects phenotypic diversity. A new paradigm in which epigenetic modifications contribute to the inheritance of phenotypes across generations is gaining support and could transform the way we understand inherited vulnerability to disease. Unlike DNA-centric inheritance models, epigenetic inheritance also incorporates the inheritance of acquired traits whereby environmental exposures that alter a phenotype in one generation can be transmitted epigenetically to unexposed offspring. This notion has profound implications for understanding disease etiology but also for basic mechanisms of evolution. For this reason, NIAAA is interested in studies that examine the transgenerational effects of alcohol exposure and how epigenetic inheritance might contribute to this process.
Evidence for transgenerational epigenetic inheritance in mammals
Although transgenerational epigenetic inheritance is a well-documented phenomenon in plants and fungi, it was not convincingly demonstrated in mammals until relatively recently. Epigenetic regulation of the agouti viable allele (Avy) in isogenic mice caused alterations in coat color and an obesity/diabetes-like phenotype. This aberrant phenotype was transmitted to subsequent generations via an epigenetic modification in the female germline. In addition, epigenetic inheritance at the Avy allele has produced evidence that an environmental agent can change the germline epigenetic state of the allele, and that the induced change can be acted on by selection. There is also evidence of epigenetic inheritance in humans, but this evidence is less direct compared to the rodent studies. Germline epimutations in the human DNA mismatch repair gene MLH1 were associated with cancer and this 'epimutation' was transmitted to offspring. Although these examples demonstrate that transgenerational epigenetic inheritance is a real phenomenon, the full extent to which it functions to alter disease susceptibility is unknown.
Transgenerational effects of alcohol
Transgenerational effects of alcohol were initially demonstrated in rodent models more than twenty years ago. For example, male rats chronically exposed to alcohol and mated with alcohol-naïve female rats produced offspring with cognitive, physiological and behavioral abnormalities in adulthood. The offspring of the alcohol exposed male parent were never exposed to alcohol, yet still showed pronounced behavioral impairments suggesting that some mechanism exists for transmitting this phenotype across generations. At the time of these studies little was known about the molecular aspects of epigenetics and how the environment (namely alcohol exposure) can modify epigenetic marks. However, in the last five years a substantial amount of information has accumulated on the role of epigenetic mechanisms in the acute and chronic effects of alcohol. The majority of these studies link alcohol-induced epigenetic modifications to phenotypes such as alcohol consumption and anxiety. These studies are important but do not address whether alcohol-induced epigenetic modifications can be transmitted to subsequent generations and affect the phenotype of unexposed offspring. In addition, sons of alcoholics show cognitive, physiological and psychological problems with an increased risk for developing alcoholism, which could be interpreted as a transgenerational effect of alcohol similar to the rodent studies. Genetic variants that are inherited clearly play a role in this increased vulnerability in sons of alcoholics, but the role of epigenetic inheritance in the vulnerability to alcoholism is unknown. If epigenetic inheritance is a mechanism of the transgenerational effects of alcohol, then this would have profound implications for understanding vulnerability to alcoholism.
Types of studies relevant to this FOA include, but are not limited to:
Funding Instrument
Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.
Application Types Allowed
The OER Glossary and the SF 424 (R&R) Application Guide provide details on these application types.
Funds Available and Anticipated Number of Awards
The number of awards is contingent upon NIH appropriations, and the submission of a sufficient number of meritorious applications.
Award Budget
Application budgets are not limited, but need to reflect actual needs of the proposed project.
Award Project Period
Scope of the proposed project should determine the project period. The maximum period is 5 years.
NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made in response to this FOA.
Higher Education Institutions
The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
Nonprofits Other Than Institutions of Higher Education
For-Profit Organizations
Non-domestic (non-U.S.) Entities
(Foreign Institutions) are eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.
Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Applicant organizations must complete the following registrations
as described in the SF 424 (R&R) Application Guide to be eligible to apply
for or receive an award. Applicants must have a valid Dun and Bradstreet
Universal Numbering System (DUNS) number in order to begin each of the following
All Program Directors/Principal Investigators (PD(s)/PI(s))
must also work with their institutional officials to register with the eRA
Commons or ensure their existing eRA Commons account is affiliated with the eRA
Commons account of the applicant organization.
All registrations must be completed by the application due date. Applicant organizations are strongly encouraged to start the registration process at least 6 weeks prior to the application due date.
Any individual(s) with the skills, knowledge, and resources
necessary to carry out the proposed research as the Program Director/Principal
Investigator (PD/PI) is invited to work with his/her organization to develop an
application for support. Individuals from underrepresented racial and ethnic
groups as well as individuals with disabilities are always encouraged to apply
for NIH support.
For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF 424 (R&R) Application Guide.
This FOA does not require cost sharing as defined in the NIH Grants Policy Statement.
Applicant organizations may submit more than one application, provided that each application is scientifically distinct.
NIH will not accept any application that is essentially the same as one already reviewed within the past thirty-seven months (as described in the NIH Grants Policy Statement), except for submission:
Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the "Apply for Grant Electronically" button in this FOA or following the directions provided at Grants.gov.
It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide, except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
For information on Application Submission and Receipt, visit Frequently Asked Questions – Application Guide, Electronic Submission of Grant Applications.
The forms package associated with this FOA includes all applicable components, mandatory and optional. Please note that some components marked optional in the application package are required for submission of applications for this FOA. Follow all instructions in the SF424 (R&R) Application Guide to ensure you complete all appropriate "optional" components.
All page limitations described in the SF424 Application Guide and the Table of Page Limits must be followed.
All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions:
Resource Sharing Plan
Individuals are required to comply with the instructions for the Resource Sharing Plans (Data Sharing Plan, Sharing Model Organisms, and Genome Wide Association Studies (GWAS)) as provided in the SF424 (R&R) Application Guide, with the following modifications:
Do not use the Appendix to circumvent page limits. Follow all instructions for the Appendix as described in the SF424 (R&R) Application Guide.
Foreign (non-US) institutions must follow policies described in the NIH Grants Policy Statement, and procedures for foreign institutions described throughout the SF424 (R&R) Application Guide.
Part I. Overview Information contains information about Key Dates. Applicants are encouraged to submit in advance of the deadline to ensure they have time to make any application corrections that might be necessary for successful submission.
Organizations must submit applications via Grants.gov, the online portal to find and apply for grants across all Federal agencies. Applicants must then complete the submission process by tracking the status of the application in the eRA Commons, NIH's electronic system for grants administration.
Applicants are responsible for viewing their application in the eRA Commons to ensure accurate and successful submission.
Information on the submission process and a definition of on-time submission are provided in the SF424 (R&R) Application Guide.
This initiative is not subject to intergovernmental review.
All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.
Pre-award costs are allowable only as described in the NIH Grants Policy Statement.
Applications must be submitted electronically following the instructions described in the SF 424 (R&R) Application Guide. Paper applications will not be accepted.
Applicants must complete all required registrations before the application due date. Section III. Eligibility Information contains information about registration.
For assistance with your electronic application or for more information on the electronic submission process, visit Applying Electronically.
All PD(s)/PI(s) must include their eRA Commons ID in the Credential field of the Senior/Key Person Profile Component of the SF 424(R&R) Application Package. Failure to register in the Commons and to include a valid PD/PI Commons ID in the credential field will prevent the successful submission of an electronic application to NIH.
The applicant organization must ensure that the DUNS number it provides on the application is the same number used in the organization's profile in the eRA Commons and for the Central Contractor Registration (CCR). Additional information may be found in the SF424 (R&R) Application Guide.
See more tips for avoiding common errors.
Upon receipt, applications will be evaluated for completeness by the Center for Scientific Review, NIH. Applications that are incomplete will not be reviewed.
Applicants requesting $500,000 or more in direct costs in any year (excluding consortium F&A) must contact NIH program staff at least 6 weeks before submitting the application and follow the Policy on the Acceptance for Review of Unsolicited Applications that Request $500,000 or More in Direct Costs as described in the SF 424 (R&R) Application Guide.
Applicants are required to follow the instructions for post-submission materials, as described in NOT-OD-10-115.
Important Update: See NOT-OD-16-006 and NOT-OD-16-011 for updated review language for applications for due dates on or after January 25, 2016.
Only the review criteria described below will be considered in the review process. As part of the NIH mission, all applications submitted to the NIH in support of biomedical and behavioral research are evaluated for scientific and technical merit through the NIH peer review system.
Reviewers will provide an overall impact/priority score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved, in consideration of the following review criteria and additional review criteria (as applicable for the project proposed).
Reviewers will consider each of the review criteria below in the determination of scientific merit, and give a separate score for each. An application does not need to be strong in all categories to be judged likely to have major scientific impact. For example, a project that by its nature is not innovative may be essential to advance a field.
Does the project address an important problem or a critical barrier to progress in the field? If the aims of the project are achieved, how will scientific knowledge, technical capability, and/or clinical practice be improved? How will successful completion of the aims change the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field?
Are the PD(s)/PI(s), collaborators, and other researchers well suited to the project? If Early Stage Investigators or New Investigators, or in the early stages of independent careers, do they have appropriate experience and training? If established, have they demonstrated an ongoing record of accomplishments that have advanced their field(s)? If the project is collaborative or multi-PD/PI, do the investigators have complementary and integrated expertise; are their leadership approach, governance and organizational structure appropriate for the project?
Does the application challenge and seek to shift current research or clinical practice paradigms by utilizing novel theoretical concepts, approaches or methodologies, instrumentation, or interventions? Are the concepts, approaches or methodologies, instrumentation, or interventions novel to one field of research or novel in a broad sense? Is a refinement, improvement, or new application of theoretical concepts, approaches or methodologies, instrumentation, or interventions proposed?
Are the overall strategy, methodology, and analyses
well-reasoned and appropriate to accomplish the specific aims of the project?
Are potential problems, alternative strategies, and benchmarks for success
presented? If the project is in the early stages of development, will the
strategy establish feasibility and will particularly risky aspects be managed?
If the project involves clinical research, are the plans for 1) protection of human subjects from research risks, and 2) inclusion of minorities and members of both sexes/genders, as well as the inclusion of children, justified in terms of the scientific goals and research strategy proposed?
Will the scientific environment in which the work will be done contribute to the probability of success? Are the institutional support, equipment and other physical resources available to the investigators adequate for the project proposed? Will the project benefit from unique features of the scientific environment, subject populations, or collaborative arrangements?
As applicable for the project proposed, reviewers will evaluate the following additional items while determining scientific and technical merit, and in providing an overall impact/priority score, but will not give separate scores for these items.
Protections for Human Subjects
For research that involves human subjects but does
not involve one of the six categories of research that are exempt under 45 CFR
Part 46, the committee will evaluate the justification for involvement of human
subjects and the proposed protections from research risk relating to their
participation according to the following five review criteria: 1) risk to
subjects, 2) adequacy of protection against risks, 3) potential benefits to the
subjects and others, 4) importance of the knowledge to be gained, and 5) data
and safety monitoring for clinical trials.
For research that involves human subjects and meets the criteria for one or more of the six categories of research that are exempt under 45 CFR Part 46, the committee will evaluate: 1) the justification for the exemption, 2) human subjects involvement and characteristics, and 3) sources of materials. For additional information on review of the Human Subjects section, please refer to the Human Subjects Protection and Inclusion Guidelines.
Inclusion of Women, Minorities, and Children
When the proposed project involves clinical research, the committee will evaluate the proposed plans for inclusion of minorities and members of both genders, as well as the inclusion of children. For additional information on review of the Inclusion section, please refer to the Human Subjects Protection and Inclusion Guidelines.
Vertebrate Animals
The committee will evaluate the involvement of live vertebrate animals as part of the scientific assessment according to the following five points: 1) proposed use of the animals, and species, strains, ages, sex, and numbers to be used; 2) justifications for the use of animals and for the appropriateness of the species and numbers proposed; 3) adequacy of veterinary care; 4) procedures for limiting discomfort, distress, pain and injury to that which is unavoidable in the conduct of scientifically sound research including the use of analgesic, anesthetic, and tranquilizing drugs and/or comfortable restraining devices; and 5) methods of euthanasia and reason for selection if not consistent with the AVMA Guidelines on Euthanasia. For additional information on review of the Vertebrate Animals section, please refer to the Worksheet for Review of the Vertebrate Animal Section.
Reviewers will assess whether materials or procedures proposed are potentially hazardous to research personnel and/or the environment, and if needed, determine whether adequate protection is proposed.
For Resubmissions, the committee will evaluate the application as now presented, taking into consideration the responses to comments from the previous scientific review group and changes made to the project.
For Renewals, the committee will consider the progress made in the last funding period.
For Revisions, the committee will consider the appropriateness of the proposed expansion of the scope of the project. If the Revision application relates to a specific line of investigation presented in the original application that was not recommended for approval by the committee, then the committee will consider whether the responses to comments from the previous scientific review group are adequate and whether substantial changes are clearly evident.
As applicable for the project proposed, reviewers will consider each of the following items, but will not give scores for these items, and should not consider them in providing an overall impact/priority score.
Applications from Foreign Organizations
Reviewers will assess whether the project presents special opportunities for furthering research programs through the use of unusual talent, resources, populations, or environmental conditions that exist in other countries and either are not readily available in the United States or augment existing U.S. resources.
Select Agent Research
Reviewers will assess the information provided in this section of the application, including 1) the Select Agent(s) to be used in the proposed research, 2) the registration status of all entities where Select Agent(s) will be used, 3) the procedures that will be used to monitor possession use and transfer of Select Agent(s), and 4) plans for appropriate biosafety, biocontainment, and security of the Select Agent(s).
Resource Sharing Plans
Reviewers will comment on whether the following Resource Sharing Plans, or the rationale for not sharing the following types of resources, are reasonable: 1) Data Sharing Plan; 2) Sharing Model Organisms; and 3) Genome Wide Association Studies (GWAS).
Budget and Period of Support
Reviewers will consider whether the budget and the requested period of support are fully justified and reasonable in relation to the proposed research.
Applications will be evaluated for scientific and technical merit by (an) appropriate Scientific Review Group(s), in accordance with NIH peer review policy and procedures, using the stated review criteria. Review assignments will be shown in the eRA Commons.
As part of the scientific peer review, all applications:
Applications will be assigned on the basis of established PHS referral guidelines to the appropriate NIH Institute or Center. Applications will compete for available funds with all other recommended applications. Following initial peer review, recommended applications will receive a second level of review by the appropriate national Advisory Council or Board. The following will be considered in making funding decisions:
After the peer review of the application is completed, the PD/PI will be able to access his or her Summary Statement (written critique) via the eRA Commons.
Information regarding the disposition of applications is available in the NIH Grants Policy Statement.
If the application is under consideration for funding, NIH
will request "just-in-time" information from the applicant as
described in the NIH
Grants Policy Statement.
A formal notification in the form of a Notice of Award (NoA) will be provided to the applicant organization for successful applications. The NoA signed by the grants management officer is the authorizing document and will be sent via email to the grantee's business official.
Awardees must comply with any funding restrictions described in Section IV.5. Funding Restrictions. Selection of an application for award is not an authorization to begin performance. Any costs incurred before receipt of the NoA are at the recipient's risk. These costs may be reimbursed only to the extent considered allowable pre-award costs.
Any application awarded in response to this FOA will be subject to the DUNS, CCR Registration, and Transparency Act requirements as noted on the Award Conditions and Information for NIH Grants website.
All NIH grant and cooperative agreement awards include the NIH Grants Policy Statement as part of the NoA. For these terms of award, see the NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General and Part II: Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Grantees, and Activities. More information is provided at Award Conditions and Information for NIH Grants.
Cooperative Agreement Terms and Conditions of Award
Not Applicable.
When multiple years are involved, awardees will be required to submit the Non-Competing Continuation Grant Progress Report (PHS 2590) annually and financial statements as required in the NIH Grants Policy Statement.
A final progress report, invention statement, and the expenditure data portion of the Federal Financial Report are required for closeout of an award, as described in the NIH Grants Policy Statement.
The Federal Funding Accountability and Transparency Act of 2006 (Transparency Act), includes a requirement for awardees of Federal grants to report information about first-tier subawards and executive compensation under Federal assistance awards issued in FY2011 or later. All awardees of applicable NIH grants and cooperative agreements are required to report to the Federal Subaward Reporting System (FSRS) available at www.fsrs.gov on all subawards over $25,000. See the NIH Grants Policy Statement for additional information on this reporting requirement.
We encourage inquiries concerning this funding opportunity and welcome the opportunity to answer questions from potential applicants.
Customer Support (Questions regarding Grants.gov registration and
submission, downloading or navigating forms)
Contact Center Phone: 800-518-4726
Email: firstname.lastname@example.com
GrantsInfo (Questions regarding application instructions and
process, finding NIH grant resources)
Telephone 301-710-0267
Email: firstname.lastname@example.com
eRA Service Desk (Questions regarding ASSIST, eRA Commons registration, tracking application status, post submission issues)
Phone: 301-402-7469 or 866-504-9552 (Toll Free)
Email: firstname.lastname@example.com
Matthew Reilly, Ph.D.
Program Director, Division of Neuroscience and Behavior
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Phone: 301-594-6228
Email: email@example.com
Examine your eRA Commons account for review assignment and contact information (information appears two weeks after the submission due date).
Judy Fox
Chief, Grants Management Branch
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Telephone: 301-443-4704
Email: email@example.com
Recently issued trans-NIH policy notices may affect your application submission. A full list of policy notices published by NIH is provided in the NIH Guide for Grants and Contracts. All awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.
Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 45 CFR Parts 74 and 92.
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Akademy Awards 2009
Award Winners David Faure, Celeste Lyn Paul and Peter Penz accepted by Sebastian Trueg
The Akademy Awards for 2009 have been announced, celebrating the best of KDE contributors. As always the winners are chosen by the winners from the previous year. Read on for the winners.
Aaron Seigo, as played by Sebas, one of last year's winners presenting an award
Peter Penz
Peter Penz is the developer of Dolphin and won the award for best application category. Unfortunatly Peter was not at Akademy so his award was accepted by Sebastian Trueg on his behalf.
David Faure accepts his prize
David Faure
David Faure is one of KDE's longest serving developers. He won the Jury Selection category for greatest service to KDE.
Celeste Lyn Paul
Celeste is a member of KDE's Usability team and a contributor to OpenUsability.org. She accepted the award for greatest non-application contribution to KDE. She said she was pleased at the community's acknowledgement of the work of the usability team and how it proved that improvements were noticed and appreciated.
Augustin Benito Bethencour
The final award was given to the Akademy organiser Agustin. In his acceptance speach he said he accepted the award on behalf of the whole organising team. The conference was going to make a big difference to the attitudes of people to Free Software in the Canary Islands he said.
minor typo
"The conference was going to make a big different to the attitudes of people to Free Software in the Canary Islands he said." - difference;
and is that really aseigo in the first picture ? another image change ? :)
By richlv at Tue, 2009/07/07 - 6:18am
re: minor typo
"and is that really aseigo in the first picture ? another image change ? :)"
Looks more like sebas to me, though I've never seen either of them "in the flesh", as it were :)
By SSJ_GZ at Tue, 2009/07/07 - 7:53am
Is Jonathan drunk or joking :) ?
I'm not a KDE member, but I still know the difference between Aseigo und Sebas :)
By kragil at Tue, 2009/07/07 - 7:55am
nice to see that some of the
nice to see that some of the awards goes to non coders/devs (to the usability team).
By beer at Tue, 2009/07/07 - 4:13pm
Augustin's award
What award did Augustin Benito Bethencour get, and what for?
By Matthew Smith at Tue, 2009/07/07 - 7:47pm
Re: Augustin's award
He is (one of ?) the main organizer of GCDS/Akademy.
By aneundorf at Tue, 2009/07/07 - 8:55pm
Congratulations !
Congratulation to all three, the jury again made a very good choice ! :-)
Finally David receives the award, it was about time :-)
By aneundorf at Tue, 2009/07/07 - 8:56pm

subset: commoncrawl


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I try to add .pls radio station to rhythmbox. I download the file and I click music>import file but nothing happen. I added one station before and it works fine but now it simply does not work. Also when I try to get from the file, click on
open with rhythmbox I have the error:
Couldn't start playback
Problem occurred without error being set. This is a bug in Rhythmbox or GStreamer.
I have all medibuntu installed and I have one radio station already playing. I don't know how to proceed from now and what should I check if there is something to fix. Anyone get similar problem?
(Ubuntu 12.04 64-bit Gnome3)


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Amazon has made the jump from small to big screens with its e-readers in the past, and its now done so again with its tablets. The company has just announced a new Kindle Fire HD with an 8.9-inch, 1920 x 1200 display (or 254 ppi). The device itself measures 8.8mm thick and weighs in at 20 ounces, and that high-res screen has a polarizing filter on it that promises to cut down on glare -- the touch sensor is also laminated, which Amazon says offers better sharpness and contrast. As for internals, the Fire HD 8.9 (as Amazon has distinguished it) has a TI OMAP 4470 processor, dual speakers, a front-facing HD camera, and HDMI out. As the company is happy to point out, it's also the first tablet with dual-band (2.4GHz, 5GHz) MIMO technology, which Amazon says makes the device's WiFi 41 percent faster than the latest iPad. Look for it to run you $299 for the 16GB version when it starts shipping on November 20th. Those looking for some added connectivity will also be able to opt for a Kindle Fire HD with 4G LTE for $499 (also shipping November 20th). That buys you 32GB of storage instead of the standard 16GB (a 64GB option is also available), and you'll get 250MB of data per month from AT&T if you shell out an extra $50 a year.
But that's not all, Amazon has also announced a smaller, 7-inch Kindle Fire HD that will run you just $199 (also for 16GB). It boasts most of the same specs as its larger counterpart, the big exception being the screen resolution -- you'll get 1280 x 800 here, which puts it on par with the Nexus 7. According to Amazon, you can expect 11 hours of battery life from the 7-inch model, but it's curiously not offering battery details on the Fire HD 8.9. Pre-orders for all three options start today.


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The Università Politecnica delle Marche has set up a special welcome service targeted to the needs of disabled students enrolled in the courses of our university to make education easier and more accessible .
At the time of matriculation or registration students with disabilities are requested to inform the Student Office of their faculty about their own situation adding the certification to the administrative practice.
The reception, located at Via Oberdan 12, Ancona, is available for any needs or requests of assistance or for the delivery of services for interested people.
Rector's delegate for the disabilities:
Prof. Gianfranco Romanazzi
Department of Agricultural, Food and Enviromental Sciences - D3A
Via Brecce Bianche 10 - 60131 Ancona
Tel. 071 220 4336
E-mail: email@example.com
Educational Services
Head of Service: Doriana Campetella
Tel. 071 220 2227
Info point
Anna Montesanto
Opening hours
11.00 - 13.00 Monday and Thursday
15.00 - 16.00 Wednesday
Monte Dago campus
Via Brecce Bianche 10 - 60131 Ancona
Tel. + 39 071 2204269
E-mail: firstname.lastname@example.com


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Classroom Resources
Online Lesson Plans
MCASD is dedicated to supporting educators and providing resources to promote art education in the classroom and out-of-school time learning environment.
The Museum's Education Department offers a variety of standards-based lesson plans that can be adapted for various grade levels and subjects, utilize inexpensive materials, and promote class dialogue regarding contemporary artists and the culture of our time.
Please click on the links below to download PDF lesson plans based on MCASD collection piece and exhibitions:
A Personal Perspective
Inspired by the works featured in Chicanitas: Small Paintings from the Cheech Marin Collection, this lesson plan is designed to inspire educators to extend the Museum visit into the classroom. Students will discuss how the artists in the collection were affected by their personal history and produce a "me" box, drawing from their own personal backgrounds and life experiences.
Mapping Identity
Drawing upon the theme of self-identification through geographic location evident in the American artist Iana Quesnell's work Triptych: Migration Path , students will be given the opportunity to distinguish the cultural, political, and social ways in which they relate to their physical surroundings. This one and a half hour-long lesson plan allows students grades 9-12th to collaborate and produce a piece of art that speaks to their individual and collection experiences and identity.
Based on the works of contemporary Southern California artists such as Larry Bell and John McCracken, students will use new, nontraditional materials as artistic mediums to analyze the effects of light, space, and surface on their compositions. This lesson plan is designed for grades 6-12 and encourages the discussion of artistic process and the impact a piece of art has on the surrounding environment.
California Landscape Mural
In this one-session lesson plan students will create a collaborative mural of a landscape, incorporating complementary colors and contrast. This lesson is designed for grades 4-5 and will take approximately 1 ½ hours to complete.
Recycled Sculpture
Using recycled materials, students will create a sculpture using additive and subtractive processes in a 45 minute class session. This lesson plan is designed for 3rd- 5th grade classes.
In this lesson, students will be guided by steps as they create a self-portrait using colored pastels. They will also use their self-portraits as a springboard to write a personal narrative. This lesson plan is designed for 3rd- 5th grade classes, and will take approximately 1 ½ hours to complete in one session.
Objects as Identity
Based on Rochelle Costi's Quartos , this lesson provides students with the opportunity to use one-point perspective to create a drawing of a room featuring items that reveal their identity. This lesson is designed for grades 4-6, and fills approximately one 90 minute class session.
Tattooing Objects
Inspired by the work of Dr. Lakra, an artist featured in MCASD's Viva la Revolucion , this lesson plan provides students with the opportunity to layer a tattoo design on a found object of their choice. Discussion questions are included to develop a conversation about the aesthetic value of what is conventionally thought of as a "low" artform. This lesson is oriented towards High School students, and will take 2-3 hours.
MCASD Lesson Plan Project
Surface and Light
Using industrial materials, students will experiment with surface and light to create projects inspired by the works featured in Phenomenal: California Light, Space, Surface. In this lesson, designed for grades 9-12, students will be asked to explore light, color, and the quality of their materials, which include glass and colored tissue paper.


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For decades now, Honda's line of Rancher all-terrain vehicles has pretty much been where the search for the perfect mid-size ATV starts and ends. And it's easy to see why so many thousands of Rancher owners know they've made the right choice. With a variety of models and options, it's easy to get the features you want. Plus, the Rancher just hits that sweet spot in terms of size and performance.
Every Rancher starts with the same proven Honda engine, the heart of any ATV. A 420cc liquid-cooled single-cylinder design with fuel injection, it's engineered for the kind of wide, low-revving power an ATV rider wants. And it offers something no other ATV can: Honda's legendary reliability and efficiency.
After that, the mix-and-match of features is up to you. We have models with independent rear suspension (IRS) for excellent handling and a superior ride. We also have swingarm/solid-axle models suited to riders who tow a lot, or who want a solid axle's simplicity of design. Standard manual ATV transmission, our exclusive Electric Shift Program, or Honda's revolutionary Automatic Dual Clutch Transmission (DCT) are all available, as is Electric Power Steering and your choice between two- and four-wheel drive.
A Honda Rancher is all about what Honda does best—combining innovation with proven performance. Now, which Rancher is right for you?
Front - 190 mm dual hydraulic disc
Rear - 170 mm hydraulic disc
Front - 24 x 8-12
Rear - 24 x 10-11
Front - Independent double-wishbone; 7.28 in. travel
Rear - Independent dual-arm; 8.46 in. travel
Honda Phantom Camo
Active Yellow
MSRP excludes destination charge. Visit powersports.honda.com to view applicable destination charge amount.
UTILITY ATVs ARE RECOMMENDED ONLY FOR RIDERS 16 YEARS OF AGE AND OLDER. ATVs CAN BE HAZARDOUS TO OPERATE. FOR YOUR SAFETY BE RESPONSIBLE. READ THE OWNER'S MANUAL. ALWAYS WEAR A HELMET, EYE PROTECTION AND PROTECTIVE CLOTHING. BE CAREFUL ON DIFFICULT TERRAIN. ALL ATV RIDERS SHOUD TAKE A TRAINING COURSE. (FREE FOR NEW BUYERS. ASK YOUR DEALER OR CALL ASI AT 800-887-2887). NEVER RIDE UNDER THE INFLUENCE OF DRUGS OR ALCOHOL, ON PAVED SURFACES, ON PUBLIC ROADS, WITH PASSENGERS, OR AT EXCESS SPEEDS. NO STUNT RIDING. RESPECT THE ENVIRONMENT WHEN RIDING. FourTrax and Rancher are registered trademarks of Honda Motor Co., Ltd.
*Models shown on are offered from the manufacturer and may not be in stock at the dealership.. Call or visit us for specific availability. Visit our showroom for the best pricing you will find. Rebates are limited and subject to availability on a first come first serve basis on select models. Rebates may or may not be available at the time of your purchase. Visit our showroom and speak with a sales expert or call 480-994-8400 to make a debit or credit card deposit to secure our best total pricing. SRP and Advertised price excludes destination charges, optional accessories, custom installations, applicable taxes and other dealer fees. Dealer not responsible for mistakes made on this website.


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Microsoft issues HPC, web server challenge to Linux
Imitation, not innovation, the sincerest form of flattery?
Microsoft has taken its battle against Linux and open source a notch higher with a first beta of its Windows Server 2003 Compute Cluster Edition operating system for high-performance computing (HPC), and a modular version of its IIS web server.
Bob Muglia senior vice president of Microsoft's Windows server division, announcing the Windows beta at Microsoft's Professional Developers Conference (PDC) positioned the operating system as an integrated alternative to Linux in HPC.
"[Open source] applications are not integrated into companies' Linux environments. They are built on one off environments so there's no consistency... there are real support issues," Muglia told Windows diehards.
Windows Server 2003 Compute Cluster Edition will cluster at least four, eight, 32 and 64 machines, Muglia claimed, with the ability to run jobs across different machines with different requirements and memory demands. "Windows Server 2003 Compute Cluster Edition is targeted at intensive environments," Muglia said.
Microsoft has recognized that it is trailing Linux in HPC and Windows Server 2003 Compute Cluster Edition, due in 2006, is designed to close the gap. While acceptance of the Linux threat is new, Microsoft has been chipping away at clustering since the late 1990s, when Windows 2000 - then Windows NT 5.0 - was on the drawing board.
In a second stab at open source, Microsoft on Wednesday handed out its first developer release of the next version of IIS. IIS 7.0, part of the Longhorn Server due in 2007, has dumped the web server's monolithic architecture for an Apache-style, modular approach.
By going modular, developers can quickly add and remove services and launch their web server without rebooting. Also gone is the IIS metabase, which stored all of IIS's configuration data and required machine-level skills to change or fix.
"The monolithic nature of IIS which has been a total pain for people to build applications has been replaced," Muglia said. Product unit manager Bill Staples, also speaking at PDC, added IIS 7.0 was "molded on the kind of modularity Apache is known for."
Console consolation
Muglia also used PDC to outline Windows server features for Windows Server 2003 Release 2, due later this year, and Longhorn Server for developers. Muglia sold developers on improved management and directory based security.
Windows Server 2003 Release 2 will feature federated password synchronization with Unix and support for WS-Management, the XML-based web services specification. Microsoft's Management Console (MMC) 3.0 will allow developers to write management applications using .NET managed code.
Muglia promised, too, the introduction of Microsoft's systems definition model (SDM) architecture after Windows Server 2003 Release 2. SDM, revealed at PDC in 2003, provides an architecture for application developers to build management capabilities, like setting performance thresholds, inside an application before it goes live.
SDM creates binaries and content files that are used to speed rollout to testing or runtime environments by generating installation packs.
Developers can also expect a new scripting language for management applications, called Monad. Monad is an object-oriented language based on .NET, and provides command-line based management while enabling management services to be passed between different commands. Muglia called Monad a "gigantic leap forward in management of the server."
Banging the drum on directory based security, Muglia explained developers must move beyond simple password-based log-in to web services, applications and data. With Microsoft's Active Directory the primary directory for 75 per cent of Windows customers, developers can use the directory as the foundation for identity and authentication services in a range of web, enterprise and regulatory scenarios.
"It's no longer about single sign-on, it's about dealing with HIPAA [Health Insurance Portability and Accountability Act] and compliance, privacy and identity theft. Authentication that is password based is not secure," Muglia said.
Looking further out, Muglia highlighted Longhorn Server features while releasing the first Longhorn Server Community Technology Preview (CTP) to developers. The server companion to Windows Vista is following IIS down the modularity route, with a layered approach to operating system features and architecture. Longhorn will consist of a basic foundation of the operating system, networking, security and Active Directory with additional layers for features such as antivirus.
As with Windows Vista, storage is a focus. Longhorn Server will introduce the Transactional File System (TxF), which will allow administrators to transfer files in bulk and to also roll-back a transfer in the event of a mistake. TxF will become part of new WinFS Windows storage subsystem and be used in Microsoft's SQL Sever database.®
Sponsored: Webcast: Build the next generation of your business in the public cloud


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I am a full-time textile artist and tutor living on the Essex/Suffolk border.
I teach Creaive textile courses as part of Creative Stitch based in Ipswich and run a variety of workshops nationally and around the region. I offer talks to groups.
I am a member of Out of the Fold - a group of textile artists based in East Anglia http://www.outofthefoldtextilegroup.blogspot.co.uk
My other group is Tin Hut Textiles who exhibit each September at Snape Maltings in Suffolk
Branch chair of Suffolk West Embroiderers Guild


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4 hours per week
As the largest group of employees our Sales Advisors are very important to us. We provide them with a great product to work with, some great incentives to work towards and a great team working environment.
Our Sales Advisors are key to growing sales and creating an outstanding customer experience. Being focused on the daily operational running of the store they are more than just sales people. by being customer focused, working as a team and living The Perfume Shop brand you are truly our "Perfume People" who drive the success of our business.
In return we are keen for our Sales Advisors to be able to wow our customers, to be able to sell to them and make their day. We also expect our Sales Assistant to support with living our brand, whether this is opening the store, cleaning, replenishing the shelves or supporting their management team where possible.
• Use your talent to drive sales in store and achieve your daily sales and KPI target
• Offer every customer a TPS reward card and register their details
• Work as part a team to set up new promotional campaigns in line with company guidelines and use your initiative to merchandise the store effectively
• Convert every customer through the use of all available options, eg store to door, price matching
• Deliver the Perfume Shop's "The Perfect Service" to every customer
• Strive to achieve a 100% customer love score by consistently providing excellent customer service
• Show your spark and passion when selling our products and brands
• Continuously learn about the products we sell using Company training tools, including new products
• Attend regional and training events as required and share feedback with your team
• Use the store iPAD to check competitor pricing, to find additional information on products, and to process click and collect orders
• Be a key holder for the store, following all key security procedures (over 18 only)
• Be responsible for checking and attending your planned shifts using the Company's online rota plan (Rotageek)
• Ensure stock inventory is correct at all times and carry out store stock takes when required
• Be accountable for the prevention of stock loss including theft, damages, breakage and transactional errors
• Process refunds and exchanges in line with Policy
• Follow all store and health & safety procedures correctly in line with Policy
• Cover gap shifts where possible to ensure your store trades effectively and cover other stores when required
• Keep all areas of the store, stock room(s) and staff area clean and tidy
• You love talking to customers every day and finding their perfect scent or gift
• You love perfume and the brands we sell
• You enjoy working in a team to deliver excellent results
• You like learning about new products
• You're aware of our competitors and have an interest in retail
• You wear our uniform with pride and observe the Company dress code
A healthy on target bonus
20% employee discount
Discount at Superdrug
Plenty of opportunity for training and development
up to 4% contributory pension scheme
Charity giving through payroll
Retail Trust (employee support)
Childcare scheme and plenty of in store incentives.
We opened our first three retail stores here at The Perfume Shop over 25 years ago in 1992. Since then we have grown to be the largest single category fragrance retailer in the UK and we were awarded The Fragrance Foundation 2018 national fragrance retailer of the year!
Our brand has become widely recognised across the UK and Ireland by our ever increasing presence on the high street and online, and we are proud to be owned by the A.S. Watson Group, the world's largest health and beauty retailer. The A.S. Watson Group are also known in the UK for owning Superdrug and Savers.
With year on year objectives of growing our business we are well known for offering great fragrance deals on the high street and being the 'go to' experts for service. This is proved with our top 20 placements in the past few years in the well known Which? High Street Shops Satisfaction Survey.
Apply now to become part of more
By joining us, you will be part of More than just a health and beauty retail group. You'll become part of an organisation which is well-recognised all over the world.Apply


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An Achilles' Heel: Inequality threatens Asia's growth miracle »
Source: Finance and Development, December 2013
Volume/Issue: 50/4
Series: Finance & Development
Author(s): International Monetary Fund. External Relations Dept.
Publisher: INTERNATIONAL MONETARY FUND
Publication Date: 25 November 2013
Keywords: intellectual property, global trade, supply chain, copyright
For the latest thinking about the international financial system, monetary policy, economic development, poverty reduction, and other critical issues, subscribe to Finance & Development (F&D). This lively quarterl...


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There is nothing sexy about chemo. But nothing is wrong with having sex while receiving treatment, either. In fact, if you're feeling up to it, it can be a great idea!
Make time for bonding. While you may not always be "in the mood," there will be days when you feel quite well—and will want to be intimate with your partner. In time, you'll be able to figure out when you're likely to feel ill and when you'll feel good. Expect side effects, if they occur at all, 24 to 72 hours after a session.
Deal with appearance anxiety. Hair loss, weight gain and the aftermath of surgery can take their toll. Talk through your feelings with your partner. You'll most likely learn that these issues loom much larger in your mind than in your partner's.
Closeness counts. Don't rule out cuddling or holding hands–they're a big part of intimacy.
Take precautions. If you want to be intimate the evening after a session, ask your oncologist if oral sex is okay. Some drugs appear in semen or vaginal secretions, and you wouldn't want your partner getting a chemo dose.
Combat side effects. Vaginal dryness can be an issue. To prevent painful intercourse, use a vaginal lubricant. For men, getting erections can be difficult. Drugs are an option—and insurance will generally cover them if your oncologist goes to bat for you.
One warning: Sex while you have low white blood cell counts is generally not recommended. Ask your doctor about your count and if sex is safe.
Finally, be sure to talk. Sharing dreams for the future is one of the most intimate things you can do.
|Your Sex Life
How Chemotherapy Affects Fertility


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Racists Attack Daddy Blogger Over Viral Photo of Interracial Daughters
Daddy blogger Doyin Richards spends most of his days recounting the joys of fatherhood on his website, Daddy Doin' Work: Adventures of a First-Time Father Raising His Daughters.
Last October, Doyin (pronounced doe-WEEN), 39, took a month off from his day job to "baby bond" with his newborn.
It was during this time that he snapped this adorable photo of himself styling his three-year-old's hair while the baby rests comfortably in a BabyBjörn.
Doyin says he took the photo because his wife, Mariko, refused to believe he could do his daughter's hair, and he wanted to show her that he could.
"After 15 minutes of multitasking, the final result was a nice, tight ponytail for big sister and a happily sleeping baby in the carrier. Mission accomplished," he wrote in the blog post. "I emailed the photo to her with the caption 'Boom.' and we both got a good laugh out of it."
So far so innocent, but when the photo was reposted late last month on social networking sites it quickly went viral, and that's when all Hell broke loose.
Doyin was inundated with racist comments calling his devotion into question and suggesting his daughters couldn't be his because they didn't share the same exact skin color (Mariko is half-white and half-Japanese).
"I would bet anything that you're a deadbeat," said one commenter. "OK buddy, cute picture. Now why don't you hand the children back to their mom so you can go back to selling drugs or your bootleg rap CDs?" said another.
"He probably rented those kids," said a third. "They don't even look like him."
And the vile kept coming: "Look at this Uncle Tom. No chance he would be doing this if his kids were black," read one particularly unacceptable remark. "So do you do this for all of your illegitimate kids?"
Responding to his haters with signature levelheadedness, Doyin decided not to stoop to their negativity, and instead turn their sorry behavior into a teachable moment, daddy-style.
"Why don't you put big boy shorts on and get in on the revolution of good fathers?" Doyin inquired of his detractors, rhetorically. "It's not a good look to tear down dads for doing the work your wives wished you were man enough to do on your own. If you don't believe me, just ask your spouses. They'll tell you. But don't worry. I'll still be here whenever you're ready to step your game up and join #TeamGrownAssMan."
In a lengthy response post since reposted by The Good Men Project, Doyin invokes Dr. Martin Luther King, Jr., and says he dreams of a day when "people will view a picture like this and not think it's a big deal."


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December was such a crazy month in the Quilt Dad home that I just realized I forgot to post about some of the things I received leading up to the holidays. So crazy, in fact, that I even took pictures of these things, uploaded them, and edited them ... then promptly forgot all about the final step of blogging about them. Until today.
First up, I received the giveaway prize from Michelle that I had previously blogged about. Along with the four embroidered squares, Michelle sent some additional festive holiday fabric, ribbon, and chocolate (yum!). The four charm packs pictured are my own, shown here because I think I will combine the sweet embroidered Santas into a quilt with these Merry & Bright and Holly Jolly fabrics. For 2009. Maybe.
I also received my Holiday Booty Swap package from Sharon. Now see if you can follow this: I actually had Sharon as my secret partner in the Doll Quilt Swap (quilt shown here) while, at the same time and unbeknownst to either of us, she had me as her secret partner for the Booty Swap. Needless to say, I think we were both confused when we received packages from each other ... and sent packages to each other ... for two different swaps at the exact same time (cue Twilight Zone music ...)
Sharon sent an adorable little holiday quilt, "First Snow", that was prominently displayed in our living room throughout the season. Check out those awesome little snowflake button embellishments! Sharon included some great extras, like those homespun patches shown above. I can't wait to find just the right project to use them. Suggestions welcome!
Finally, there aren't too many of us guy quilt bloggers out there, so I want to be sure I support one of my cohorts. I believe all of us straddle the line between quilter and artist, with some falling more on one side of the fence than the other. Scott over at Blue Nickel Studios is one of those quilters for whom I believe the ARTIST side is immediately apparent. He's been making some really great quilts and quilt patterns lately for the nice people at Free Spirit fabrics, including new designs for Jay McCarroll and Anna Maria Horner.
One of Scott's fabric designs, "Punk Andy", is in contention for Fabric of the Week over at Spoonflower. Please take a look and CLICK HERE to vote and support Scott in his new endeavor.


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Meet Smooth Jarvis, the new character for the PlayStation Network game PAIN, brought to you by the fine folks at AXE deodorant.
In-game advertising gets ridiculous with the introduction of Smooth Jarvis, whose "Double Pits to Chesty" special move mimics the actions involved in applying AXE brand deodorant products. Players who use PAIN's in-game video function to capture Jarvis combining the Double Pits move together with other pain moves between September 1st and 30th can enter to win fabulous prizes, like a 42" Sony HDTV, or a custom Smooth Jarvis action figure. Yay.
If you were going to be outraged over in-game advertising, now would be a good time.
PlayStation and AXE Introduce "Smooth Jarvis" and New Moves in PAIN [PlayStation Blog]


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Kanye West's new album didn't leak online over the weekend. It gushed out into the pop ecosystem like a million barrels of renegade crude — ominous, mesmerizing and of great consequence.
"Yeezus" is the rapper's sixth album and his riskiest since "808s & Heartbreak," the 2008 left turn that proved West to be one of the most powerful steering forces in contemporary pop. But where "808s" was forlorn and mysteriously triumphal, "Yeezus" is churlish and peculiarly magnetic. As the phantom choir explains in the middle of "On Sight," the album's prickly opening salvo, "He'll give us what we need / It may not be what we want."
West is unquestionably doing whatever he wants here. And whether or not we actually need these 10 mongrel pop songs, it's thrilling to watch the man discover new ways to stick out his neck. "Soon as they like you, make 'em unlike you," he growls on "I Am a God," describing the rope-a-dope methodology that's made him today's most complex pop star. (Fittingly, it's the winning line from a song about a perennial self-loather being on a first-name basis with Jesus Christ.)
"Yeezus" has already been branded as West's ugliest album, but he'll always be a populist at heart, incapable of releasing anything truly repulsive. For all of the charred melodies and serrated rhythms on "Yeezus," this is still luscious electronic music sculpted into elegant shapes that only signal threat. French dance music duo Daft Punk and studio sage Rick Rubin were called on to collaborate, helping West evoke hip-hop's icy, electro roots while echoing the sly, synthetic snarls of Depeche Mode and Nine Inch Nails.
There's still plenty of ugliness scribbled on West's lyric sheet. He plumbs the depths of his id like a knife scraping the bottom of the peanut butter jar. He turns civil-rights-era mantras into gross pillow talk that no human should ever utter in real life. He promises to get the club "shaking like Parkinson's."
"Black Skinhead" crams all of this attitude into one dystopian, Gary Glitter-ish jock jam that would be perfect for the stadium scene finale of "Akira," the legendary Japanese anime film that West adores. "I keep it 300 like the Romans," he spits during the refrain, a boast that blurs fantasy and reality, Hollywood retina candy and Chicago gang violence. ("300" is slang for Chicago's Black Disciples street gang, as well as the title of a 2007 action flick in which ancient soldiers bathe one another in CGI blood.)
Despite a handful of arresting quirks and kinks, the lyrics on "Yeezus" are West's least refined and probably his least compelling. But they don't feel lazy so much as drunk on bitterness. After engineering something as magisterial as his 2010 opus "My Beautiful Dark Twisted Fantasy," this is West at his most wasted, stumbling through rubble.
It's all over in about 40 minutes, instantly provoking questions about legacy. The last time West took a risk this great, with "808s & Heartbreak," he taught hip-hop about the potency of vulnerability and ended up paving a four-lane highway for Drake, Kid Cudi, the Weeknd and Future. Will "Yeezus" teach a rising generation of rap stars to melt poison from their frozen hearts?
And how will the auteur himself reconcile the unholy mess he's been making? "Yeezus" might blow our collective hair back for the summer, but West has to live with these tunes for the rest of his life. His girlfriend, Kim Kardashian, delivered a daughter Saturday. How do cynicism and self-obsession jibe with being a dad?
In addition to keeping us thinking about him, West's music always keeps us thinking about the future. He's a visionary who's managed to tweak the serial rhythms that dictate so much of our pop culture diet. He doesn't do cliffhangers. He jumps off.
We gasp, gawk and wonder, "Where will he land?"


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Choose among different QR code types according to your requirements.
Customize your QR code design, choosing among amazing shapes. You can even add logo and change color of different parts of QR code.
Finalize your QR code design until you are satisfied.
Once you are done with your QR code design, you can download it in PNG and SVG Vector format.
The QR code is a brand of a specific two dimensional matrix barcode. It was created by the Toyota branch Denso Wave in 1994 due to the need for tracking automotive parts during the manufacturing processes. The matrix barcode is highly secure designed and can also be reconstructed if up to 30 percent of it has been destroyed.
In the meantime, QR codes are well established to present URLs, Telephonnumbers and whole contact data e.g. business cards on websites, image brochures, online and print advertisements. They are used by smart people who recognized that most user do not want to manually write and type any data. If you are looking at a qr code, just take your mobile phone and scan it with an easy click. No need to type anything, the software on your smartphone recognize the content and you will be asked what to do next, e.g. visit a url or safe the data as a new contact. With the QR-Code-generator i offer, everyone is able to create such qr codes and to publish them on any desired media. The qr code is able to hold almost the complete textual content of this website. A maximum of 4,296 alphanumeric characters can be stored within the code.
The encoded text and data is presented in a two dimensional quadrant with black and white dots. A two-dimensional matrix barcodes is able to store approximately 100 times more data than a common linear barcode. The maximum capacity of the encoded characters is over 4,200 alphanumeric characters (numbers, letters and symbols). You find more technical and historical information about it here: Wikipedia and here
Common QR Codes contains only black and white pixeldots. There are some special variants like integrated brands or logos within the matrix or multicolor codes with different colors, but a really new and extravagant creation is shown by Russ Cox He explains how to convert a photo into a pixel matrix code and to embed it in a way that it looks like the image beside. There is a lot of content on his site, maybe you do not find the right link to the image QR-Code-Generator, so here it is: image qr code
For Android based mobile devices there is the great QR code and barcode scanner barcoo
We use the QuickScanner - It´s a very fast and accurate qr code scanner. It´s free in the app store. Get it here!
Find here a TOP 10 List of the most popular QR Code readers


text: Back in early October, we reported that David Cronenberg had written a script for his sequel to The Fly — but whether the movie actually got made was up to Fox, who were taking a look at the script. Now, Cronenberg says Fox has officially passed on the project. He tells an interviewer, "I wrote a script, and at the moment Fox is not wanting to do the project." [The Playlist]


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Computer-Mediated Communication Magazine
/ ISSN 1076-027X / Volume 2, Number 1 / January 1, 1995 / Page 1
CMC '95: Previews, Predictions, Prognostications
Editor's Page
The Nerd in the Noosphere
The Internet Liberation Front, the Lawnmower Man, monadology, neurobiology, and Tai Chi...Michael Heim pulls it all together metaphysically on this journey with stopovers in the global village and the Omega Point. Can a French Jesuit paleontologist and the Baron who invented differential calculus find common ground in a virtual community? Heim thinks so.
Cybercasting About Cyberspace
The very concept behind this special issue of
CMC Magazine
troubles Laura Gurak, who warns of the development of an explicit technological determinism that underlies the prognostication process. Gurak believes any questions we ask about the future of CMC are actually reflections of what we should be asking about society as a whole; she outlines what she considers to be the prime assumptions being made about CMC, highlighting those which deserve careful scrutiny.
Transitions in Studying Computer-Mediated Communication
The burgeoning presence of on-line activity throughout society--fostered by new CMC technologies--has changed approaches to studying CMC since the field's beginnings in the 1970's. John December explores new issues that researchers should attend to, and offers his predictions for how scholarship, technology, and society will continue to change during the coming year.
Can We Keep Community Networks Running?
Although civic computer networks provide valuable services to local communities, these grassroots efforts are facing a myriad of threats to their existence, such as unstable funding, increased competition, and limited technical resources. Steve Cisler looks at the challenges that community networks are facing, and he offers suggestions for keeping them running in the face of these obstacles.
What's Dis'Course About? Arguing CMC into the Writing Classroom
Purdue's Bill Hart-Davidson takes the CMC argument to a specific battlefront: that which was once called "Freshman Composition." What happens when writing no longer equals print? Instructors are forced to reconsider what they're teaching and why they're teaching it in the first place. Hart-Davidson asks, and begins to answer, the question that faces all writing teachers who favor CMC: How can we argue our case more effectively than we have been?
MUDS in Education: New Environments, New Pedagogies
The use of multi-user domains in the writing classroom can benefit both teacher and student; according to Louisville's Tari Fanderclai, MUDs even provide students with opportunities for "incidental," self-motivated learning. But the insistence of many academicians on utilizing MUDspace to perpetuate traditional notions of classroom education has Fanderclai worried about the future of educational MUDding.
The View from Singapore: Re-Imagining the Wild, Wild Web
From halfway around the world, international electronic commerce professional Thomas I.M. Ho never felt far from home, thanks to the World-Wide Web. His take on the bullish and bearish features of the national information infrastructure and the commercial potential of the Internet suggests an exciting, if not entirely rosy future.
Reconceptualizing the Virtual: Bringing CMC Back into this Reality
We need to re-think the concept of "virtuality" itself, according to Greg Siering, particularly when we're considering MUDspace. The rapid growth of educational and professional MUDs is raising a "real" problem --the "real life" priorities of businesses and the academy. Siering calls for a reconceptualization of MUDs as "communicative environments," among other necessary changes.
It's Fun to Have Fun But You Have to Know How!
or, How Cavorting on the Net Will Save the Academy
Rebecca Rickly, Eric Crump and others tackle the tough issue of why folks in the academy resent the sense of play that seems intrinsic to cyberspace. Follow their Borgesean, hypertextual frolic as they argue for more fun in the halls of academe.
Do Computers Matter?
Are computers any more important now for the average person than they were 30 years ago? Does the explosion in sales of multimedia PCs signal that the digital revolution--so long predicted for the middle-class household--has finally arrived? Peter Jerram takes a look at the sort of cultural revolution(s) that the PC is bringing to those households.
Of Ivory Towers and Infobahns
Metaphor, metaphor, who's got the metaphor? In our haste to name the tools that allow for computer-mediated communication, are we forgetting the effect the naming process itself can have? Mick Doherty and Kevin Hunt swap a series of letters arguing the point.
Letters to the editor always welcome:
CMC Studies Center


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Twelve-year-old Sophie has never quite fit into her life. She's skipped multiple grades and doesn't really connect with the older kids at school, but she's not comfortable with her family, either. The reason? Sophie's a Telepath, someone who can read minds. No one knows her secret—at least, that's what she thinks…
But the day Sophie meets Fitz, a mysterious (and adorable) boy, she learns she's not alone. He's a Telepath too, and it turns out the reason she has never felt at home is that, well…she isn't. Fitz opens Sophie's eyes to a shocking truth, and she is forced to leave behind her family for a new life in a place that is vastly different from what she has ever known.
But Sophie still has secrets, and they're buried deep in her memory for good reason: The answers are dangerous and in high-demand. What is her true identity, and why was she hidden among humans? The truth could mean life or death—and time is running out.
Sophie is settling in nicely to her new home and her new life in the world of the lost cities. And it helps that living at Havenfield means getting to spend time with rare, precious species—including the first female Alicorn, who shows herself to Sophie and trusts no one but her.
Sophie is tasked with helping to train the magical creature so that the Alicorn can be revealed to the people of the lost cities as a sign of hope, and Sophie wants to believe that the recent drama and anguish is gone for good.
But the secrets buried deep in Sophie's memories remain, and before long before she's back in incredible danger, risking everything to find the answers to questions that could save not only her life, but the life of someone close to her…
Sophie Foster is ready to fight back.
Her talents are getting stronger, and with the elusive Black Swan group ignoring her calls for help, she's determined to find her kidnappers—before they come after her again.
But a daring mistake leaves her world teetering on the edge of war and causes many to fear that she has finally gone too far. And the deeper Sophie searches, the farther the conspiracy stretches, proving that her most dangerous enemy might be closer than she realizes.
In this nail-biting third book in the Keeper of the Lost Cities series, Sophie must fight the flames of rebellion, before they destroy everyone and everything she loves.
Sophie Foster is on the run—but at least she's not alone.
Her closest friends from the Lost Cities have gone with her to join the Black Swan. They still have doubts about the shadowy organization, but the only way to find answers is to start working with them. And as they settle into their new lives, they uncover secrets bigger than anything they'd imagined.
But their enemies are far from done, and they unleash a terrifying plague that threatens the safety of an entire species. Sophie and her friends fight with everything they have—with new allies joining them—but every choice has consequences. And trusting the wrong person could prove deadly.
In this game-changing fourth book in the Keeper of the Lost Cities series, Sophie must question everything to find a truth that will either save her world—or shatter it.
Dark schemes unfold—and Sophie's loyalty is pushed to the limit—in this thrilling fifth book in the bestselling Keeper of the Lost Cities series.
Sophie Foster is back in the Lost Cities—but the Lost Cities have changed. The threat of war hangs heavy over her glittering world, and the Neverseen are wreaking havoc.
The lines between friend and enemy have blurred, and Sophie is unsure whom to trust. But when she's warned that the people she loves most will be the next victims, she knows she has to act.
A mysterious symbol could be the key—if only she knew how to translate it. Every new clue seems to lead deeper into her world's underbelly and the Black Swan aren't the only ones who have plans. The Neverseen have their own Initiative, and if Sophie doesn't stop it, they might finally have the ultimate means to control her.
Sophie and her friends face battles unlike anything they've seen before in this thrilling sixth book of the New York Times and USA TODAY bestselling Keeper of the Lost Cities series.
Sophie Foster is struggling. Grieving. Scrambling. But she knows one thing: she will not be defeated.
The Neverseen have had their victories—but the battle is far from over. It's time to change tactics. Make sacrifices. Reexamine everything. Maybe even time for Sophie to trust her enemies.
All paths lead to Nightfall—an ominous door to an even more ominous place—and Sophie and her friends strike a dangerous bargain to get there. But nothing can prepare them for what they discover. The problems they're facing stretch deep into their history. And with time running out, and mistakes catching up with them, Sophie and her allies must join forces in ways they never have before.
Sophie Foster doesn't know what—or whom—to believe. And in a game with this many players, the worst mistake can be focusing on the wrong threat.
But when the Neverseen prove that Sophie's far more vulnerable than she ever imagined, she realizes it's time to change the rules. Her powerful abilities can only protect her so far. To face down ruthless enemies, she must learn to fight.
Unfortunately, battle training can't help a beloved friend who's facing a whole different danger—where the only solution involves one of the biggest risks Sophie and her friends have ever taken. And the distraction might be exactly what the villains have been waiting for.
Read an Excerpt >
Illusions shatter-and Sophie and her friends face impossible choices-in this astonishing eighth book in the New York Times and USA TODAY bestselling Keeper of the Lost Cities series.
Sophie Foster wants answers. But after a lifetime of lies, sometimes the truth is the most dangerous discovery. Even the smallest secret comes with terrifying new responsibilities.
And Sophie's not the only one with blank spots in her past, or mysteries surrounding her family. She and her friends are part of something much bigger than they imagined-and their roles have already been chosen for them.
Every clue drags them deeper into the conspiracy. Every memory forces them to question everything-especially one another. And the harder they fight, the more the lines blur between friend and enemy.
Sophie Foster has always felt out of place. Her remarkable intelligence, which has made her a high school senior at only twelve years old, has also left her disconnected from everything and everyone—even her family. She's also been hiding her ability to read minds, thinking it's because she fell and hit her head when she was five. But when she meets a beautiful and intriguing boy named Fitz on a class field trip, Sophie discovers it's actually because she isn't human at all! She's an elf, just like Fitz, and is part of a secret world hidden on our planet called the Lost Cities.
From that moment on, Sophie's life is forever changed. Leaving behind the human world she's only ever known, Sophie embarks on an incredible journey to discover where she truly belongs and uncovers new abilities, new friends, and the powerful and extraordinary individual she was always meant to be.
Dex Dizznee is Sophie's best friend in the Lost Cities and immediately takes Sophie "under his wing." He introduces her to the teachers and students that make up Foxfire Academy and helps her find her way around the humongous campus. He doesn't have a special ability when Sophie first meets him, but she can tell he's incredibly talented. When he isn't busy playing a practical joke on the school bully Stina, or working at Slurps and Burps, his parents' special apothecary, Dex is right by Sophie's side, looking out for her, helping with anything she needs, and tutoring her in her most challenging subjects.
Best of all, he knows how to make her laugh—though sometimes he wishes he could make her feel something…more. He's happy to be her friend, but he can't help having a huge crush on her too, and is less-than-thrilled to find himself in a competition with Fitz—and maybe Keefe—to win Sophie's heart.
Keefe Sencen is Foxfire Academy's resident troublemaker—though he'll of course claim he had nothing to do with "The Great Gulon Incident." Confident and cute, with infamously awesome hair, he's always ready with the perfect joke or prank to make everyone laugh. Naturally that makes him quite popular at school (though not nearly as popular with the teachers). But while he may be a regular in detention—and know all the best places to ditch class—there's so much more to Keefe than his prankster ways.
His photographic memory has allowed him to skip an entire grade level, and he's an excellent friend to Fitz and Biana. He also befriends Sophie from the moment he meets her—and not just because he loves teasing her. His ability as an Empath allows him to read her feelings, which helps him understand her in ways no one else can. He's always there when she needs him, whether she realizes she needs his help or not. If only he could understand his own feelings for her as easily…
Fitz Vacker is the confident teal-eyed heartthrob who spent years secretly helping his dad search for Sophie in the human world. And despite coming from a famously important family, he's actually very down-to-earth. Like Sophie, he's a Telepath, though not *quite* as powerful as she is. And even though he's two grade levels ahead of Sophie at Foxfire Academy—the school they both attend—he still sits with her at lunch. He's best friends with Keefe, but he's also "Mr. Popular," and quite a few girls at Foxfire are known to have crushes on him. He never knows what do do what that, just like he doesn't always know the right thing to say to Sophie.
But he cares about her more than she knows—more than he knows, sometimes. Maybe it's because he saw how hard it was for Sophie to leave her human life behind, or because she's close in age to his younger sister, Biana, but he feels a special connection with Sophie, and does everything he can to keep her happy and safe.
Biana Vacker may seem like the Princess of Foxfire Academy—but don't let the perfect hair and fashionable dresses fool you. Yes, her family is kinda famous, and most people think she's the prettiest girl in school, but beneath all the makeup and perfectly coordinated accessories is an incredibly loyal friend. She's fiercely protective of her brother, Fitz, especially from the silly girls always crushing on him. And once she gets past some misunderstandings with Sophie, they become very close.
Biana may not have manifested her special ability when we first meet her, but that never stops her from taking on Fitz and Keefe in a game of base quest, (And no, that's not just because Keefe is so cute—though that definitely *does* help). She's also not afraid to tackle or throw a few punches either—so long as she can still do it in heels. And when it comes to understanding boys, Biana might be the best. Hopefully she can help Sophie sort things out.
SHANNON MESSENGER graduated from the USC School of Cinematic Arts where she learned—among other things—that she liked watching movies much better than making them. She's studied art, screenwriting, and television production, but realized her real passion was writing for kids and teens. She is the author of the middle grade series Keeper of the Lost Cities and the young adult novels Let the Sky Fall and Let the Storm Break. She lives in Southern California with her husband and an embarrassing number of cats. Find her online at ShannonMessenger.com.


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Pa. lawmakers mull prescription drug monitoring
State lawmakers, spurred by a rise in prescription drug overdose deaths, are considering a monitoring effort aimed at preventing people from other states who are addicted to narcotic painkillers from obtaining the drugs in Pennsylvania.
Canonsburg pharmacist Gerald O'Hare told The (Washington) Observer-Reporter (http://bit.ly/YY6e37 ) that he refused to fill five such prescriptions Friday at his Jeffrey's Drugstore, suspecting people were trying to use cash to get illegal supplies of the drugs. He said he doesn't have that problem at a pharmacy he owns in Ohio because the state runs prescriptions through a computerized central monitoring program to identify physicians and customers who abuse the system.
"The dealers are moving out. Now pharmacies are seeing these customers with all kinds of sob stories from Ohio, Kentucky, West Virginia and Tennessee," said Rep. Brandon Neuman, D-North Strabane Township, who said he wants to amend state law to help prevent addicts from easily using cash to get narcotics by traveling to different physicians and pharmacies in the commonwealth.
State House lawmakers have forwarded from committee for a final vote on the floor a measure to set up a Pennsylvania Accountability Monitoring System database that would flag patients or customers who have already received an adequate supply of Schedule II drugs containing opiates or synthetic opiates.
Washington County District Attorney Gene Vittone said the law would be a major tool in preventing the illegal use of such drugs as Oxycontin. He said his office has made prescription drug abuse a priority, given the high number of local overdose deaths.
Coroner Tim Warco said he investigated 40 overdose deaths last year in Washington County, 17 of which involved the use of opiates. There were 46 overdose deaths the previous year, while 28 people died in that fashion in 2003 and just two in 1992.
Vittone called those figures "off the charts," since statistics from the federal Substance Abuse and Mental Health Services Administration would indicate that for its population Washington County should only be seeing half as many such deaths a year.
Prescription drug abuse has also fueled a rise in heroin trafficking since people who can't afford the price of Oxycontin turn to heroin as a cheaper alternative, Vittone said. He said Kentucky's problem of dealers and addicts getting such drugs by "doctor shopping" was "eliminated almost immediately" after that state in July put in a monitoring system like the one being considered in Harrisburg.
The Westmoreland County coroner's office said it investigated a record 71 drug overdose deaths last year and has probed 16 such cases in the first six weeks of this year -- five of them occurring in one week's time.
Greene County Coroner Gregory Rohanna said he doesn't keep cause-of-death records but "obviously, I see more (overdose deaths) now than I did 10 or 15 years ago."
Information from Observer-Reporter, http://www.observer-reporter.com