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Rancho steering stabilizers are designed to improve vehicle control by reducing steering shimmy and driver fatigue. Stabilizers enable you to help protect your front-end suspension components and reduce tire wear.
Added this to match the shocks from the same series, and loved the control over my death wobble at the time, temporary problem. After solving DW I could not overcome the steering wanting to push left constantly and removed it to confirm it was steering stabilizer. Disappointed because it is a great stabilizer, but without it I can track straight without hands on wheel.
Awesome, 2012 JK 33x12.50x18 drives great..
I bought this stabilizer because my factory stabilizer was worn out. I couldn't believe the difference in the two. My TJ drives like a new one. Great product and easy to install.
I had really bad death wobble when I hit pot holes or braked hard on rough roads. Thought it was the trac bar so I installed a new adjustable trac bar (and a 4" lift w/ new 35" tires) but the lift just amplified the problem. I got an alignment (w/ caster adjustment bolts) and it helped a little with overall driving feel but didn't fix the problem. I ordered this stabilizer to match the shocks I installed with the lift. When I removed the old stabilizer I realized the eyelet was broken because the mount was too far toward the driver's side of the vehicle and it was getting over extended. I moved the mount and installed the new stabilizer and haven't had a death wobble since. Jeep feels much more solid. It says you have to buy the Stabilizer Kit (Part # RANRS5510) but I used the factory hardware and one washer that came with the stabilizer. Saved me $40.
is the rancho rs7000mt better then the fox racing 2.0.. my application is a 98 tj w/35" tires and 4"zone lift
Asked by tiny from on
Hi Tiny They are both very good quality, the Fox may be a little tougher as it is designed for racing specs. But both will do what you need. Thanks
Answered by LWiff ext 4804 from on
dose this steering stabilizer has neutral resistance between the right side and the left side will not pull to the right or left when driving down the road?
Asked by Brian from Toms River NJ. on
Brian, your steering stabilizer shouldn't have enough force to push the wheel one way or the other. I would recommend a hydraulic style steering stabilizer. This RS7000 MT has a high-pressure gas charge that separates the unit internal oil and nitrogen to provide additional spring rate. This helps to maximize damping response that dissipates heat for better control.
Answered by Jason L from Toms River NJ. on
Since the 1950s, Rancho has been a top innovator and industry leader in the research, design and manufacturing of performance parts and accessories including suspension and leveling systems, shock absorbers and associated on and off-road products for Jeeps and custom off-road vehicles. A rich Jeep heritage makes the Rancho brand and its full complement of suspension systems (4-inch and up) for Jeep CJ, JK, LJ, TJ, XJ and YJ models and rockGEAR products instantly recognized in the jeeping community. Rancho's line additionally features an extensive array of high performance suspension kits and ride control components for SUVs and trucks. Exhaustively tested and engineer driven to meet today's demanding standards, Rancho products are in a class of their own. Every one of their shocks and suspension and leveling systems includes a limited lifetime warranty, and Rancho's shocks include a 90-day ride guarantee. Established in the off-road performance community, Rancho's product line is continuously evolving to develop the latest innovations for Jeeps, trucks and SUVs. Shop Rancho Now


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Afghanistan's presidential race kicked off Monday as election authorities began accepting the nominations of would-be candidates, the start of a wide-open race whose winner will oversee the final phases of the withdrawal of U.S.-led troops amid a relentless Taliban insurgency.
The first day of registration drew ... no one.
No major candidates are expected to submit their nominations until closer to the Oct. 6 deadline, part of a waiting game to see how the field shapes up.
The election, set for April 5, will determine who succeeds incumbent President Hamid Karzai, who has in some form or shape led Afghanistan since the Taliban government was ousted in the American-led invasion in 2001. Karzai, who will have served two five-year terms, is barred from running for a third.
Candidates have until Oct. 6 to submit their names and meet election requirements, including depositing a fee of 1 million Afghanis ($18,000) and proving they have the backing of 100,000 people.
At least 20 people have picked up information packages about running for president in recent days, but there were no submissions on Monday, said Sareer Ahmad Barmak, an election commissioner.
There are no clear favorites in the race, but speculation in recent days has focused on Foreign Minister Zalmai Rassoul. Rassoul is a former national security adviser with a medical degree who has tended to stay out of the limelight and could end up being a consensus candidate among some of the many political factions in this nation of 31 million.
Other potential candidates include: Abdullah Abdullah, an opposition leader who lost to Karzai in 2009; Ashraf Ghani, a well-known academic and former finance minister with a reputation as a technocrat who also lost the last election; Hanif Atmar, a former interior minister who has grown critical of Karzai; and Farooq Wardak, the education minister who has been involved in efforts to pursue peace talks with Taliban insurgents.
Some speculation also has focused on Abdul Rab Rasoul Sayyaf, an influential lawmaker with a long history as a jihadist and allegations of past links to Arab militants including Osama bin Laden. He would likely be the most controversial candidate, at least among Afghanistan's foreign allies.
Afghanistan is a desperately poor, ethnically fractious country whose economy relies heavily on foreign assistance. Its politics are marked by patronage and alliances among the elite - a demographic that includes warlords and tribal elders who can marshal votes.
But those alliances are very fluid, and so-called political coalitions that have been set up in recent months have quickly experienced fissures. Even within ethnic groups - the population is roughly 42 percent Pashtun, 27 percent Tajik, 9 percent Hazara, and 9 percent Uzbek along with other, smaller factions - there are divisions that make it difficult to predict who will line up with whom.
Karzai, who has been accused of being unwilling to crack down on the pervasive corruption in his government, has said he would not endorse a candidate, but his presence is expected to loom large during the campaign.
Also looming are the Taliban, the militant Islamists who ruled the country from 1996-2001 before being overthrown by America after refusing to hand over bin Laden, whose al-Qaida terrorist network staged the Sept. 11 attacks. The Taliban insurgency has strengthened in recent years and seems primed to wreak more havoc as U.S.-led foreign troops finish withdrawing in late 2014, leaving Afghan troops fully in charge.
Whether the election can be held safely is a major concern, as is whether it can be held without fraud. The 2009 elections were marred by allegations of vote-rigging against Karzai's camp.
Thomas Ruttig, an expert with the Afghanistan Analysts Network, said there are already warning signs about how the vote will go April 5, including reports of "many more voter cards in circulation than voters in Afghanistan" and failures to make progress in peace talks with the Taliban.
At this stage, "one has to be doubtful about how reliable these elections will be," he said.

subset: commoncrawl


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Since it was first introduced into American Medicine by Native Americans in the late 1800's, Echinacea has been one of the most widely used herbs on this continent. With modern research, scientists worldwide are validating the many ways in which Echinacea can strengthen the body's defenses. Echinacea's popularity continues to grow – it is one of the most useful herbs to keep on hand for household use.
Planetary Herbals offers three different products containing premium grade, freshly harvested, pure Echinacea. Obtaining freshly harvested material is essential because Echinacea plants rapidly lose their potency when exposed to heat and light. Once powdered, they can lose their strength in as little as six months.
Our harvesters send us whole roots of the current season's Echinacea. The roots are custom powdered, tableted or extracted immediately, and placed in tightly sealed, light-proof or amber bottles. This ensures that every bit of Echinacea potency is maintained. When properly prepared, Echinacea can remain vitally potent for years.
Echinacea Glycerites™
Unfortunately, the bitter, pungent taste of Echinacea in liquid extract form makes it difficult for many people, especially children, to ingest. Echinacea Glycerites are a great tasting alternative to traditional liquid supplements. The Echinacea used in Echinacea Glycerites is first extracted in alcohol to harness all the benefits of the herb. Then, the alcohol is evaporated off and naturally sweet glycerin is used as the carrier. Available in delicious lemon, peppermint and orange flavors, these are sure to be a hit with kids of any age!
Because of the wide range of benefits that it possesses, Echinacea is one of the most sought-out herbs in the Western world. Give yourself the best of what this herb has to offer with Planetary Herbals' premier Echinacea products.


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FlexiTag - Sling Id-tag for GrabiQ sling
ID tag Grade 8
Load Pin Set Berglok BLA
Load Pin Set CLS GrabiQ
Locking Set SKA
Spare part UKN
Spare part BK
Spare Part BKD / BKLKD
Spare part CS GrabiQ


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4 large sheets dried bean curd,cut into 1/2,thawed
1 lb minced pork or plus extra
8 oz water chestnut,peeled and diced small(I used canned )
1 medium carrot,peeled ,shredder and chopped small
1 stalk scallion,cleaned and cut small
2 sliced boneless tilapia,diced small
10 large shrimp,cleaned ,shelled and diced small
2 eggs
enough oil for frying
1 tbsp 5 spice powder
1 tbsp seasalt or to taste
2 tbsp oyster sauce
2 tbsp sesame oil
1 tbsp sugar
1 tbsp ground white pepper powder
1:Use a large bowl,add in minced pork,shrimp,fish,carrot,scallion,water chestnut,eggs and seasoning,mix well.
2:Remove dried bean curd skin from plastic bag,if it's too dry,sprinkle some cold water onto it evenly.Don't sprinkle too much water it's will damage the skin.Cut bean curd skin about 12 x 12 inch or up to your desire size.
3:Lay a sheet of skin on a clean chopping board or table,fill 2 tbsp meat mixture or more in oblong shape,then tuck the skin and roll up tightly before seal with water or egg mixture,set aside on a clean plate.
4:Heat fryer or large skillet with oil at medium high heat.When oil is hot enough,slowly place roll lobak onto the fryer.Fry lobak evenly about 5 minutes or until golden brown.
5:Drain fried lobak from fryer and placed fried lobak on a paper towel to drain excess oil.Let it cool down before cut and serve with sweet Thai's sauce.


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Ancient Egyptian Hieroglyphics Quiz
This quiz offers you a fun way to test your knowledge of Ancient Egyptian Hieroglyphics (14 questions).
African Mask Quiz
African Mask Quiz 1 tests your ability to identify individual mask designs while African Mask Quiz 2 tests your knowledge of the people and customs associated with a mask.
Ancient Egyptian Art Quiz
Our Ancient Egyptian Art Quiz tests what you know about Ancient Egyptian culture: their Art, Gods, Crowns and Hieroglyphics.
Color Theory Quiz
Our Color Quiz tests your knowledge of the physical and psychological properties of color including color theory, color terms, color mixing and color symbolism.
Art Movements Quiz
Our Art Movements Quiz tests your knowledge of the great artists associated with each movement and your ability to recognise their individual styles of art.


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Login Required
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When volcanic ash darkened the atmosphere, it is said that Volcarona's fire provided a replacement for the sun.
A sea of fire engulfs the surroundings of their battles, since they use their six wings to scatter their ember scales.
Contact with the Pokémon may burn the attacker.
The Pokémon Company International is not responsible for the content of any linked website that is not operated by The Pokémon Company International. Please note that these websites' privacy policies and security practices may differ from The Pokémon Company International's standards.
Pokemon.com administrators have been notified and will review the screen name for compliance with the Terms of Use.
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If you blinked, you very well may have missed the Junior Symphony Guild's 2008 Designer Showhouse. It was open to the public for a period just shy of two weeks; in previous years, Showhouses had runs lasting a month or so.
However, those fortunate enough to have seen what teams of talented designers did to give the historic Phipps Tennis Pavilion a much-needed sprucing up are still talking about what an amazing transformation it was.
Built for the late U.S. Sen. Lawrence C. Phipps on the grounds of the storied Phipps Mansion in Denver's Belcaro neighborhood, the pavilion, which was completed in 1932, had grown a little raggedy around the edges in recent years thanks to wear and tear generated by wedding receptions, fund-raisers and other public events. Though the structure is owned by the University of Denver, attention to it had waned.
The senator and his wife, Margaret, had started the massive construction project in order to provide business and jobs during the Depression. The Tennis Pavilion was the first indoor court west of the Mississippi River. , and boasted an 8,000-square-foot tennis area, living room, gallery, kitchen, men's and women's dressing rooms, and an upstairs apartment.
The living room has stained glass windows and a winter mural by Colorado artist Allen True. The wall of windows in the gallery opens to an expanse of gardens.
A soda fountain that adjoins the small kitchen has wonderful history. The Phipps family tradition was to sign the walls of the soda fountain during their annual New Year's party and other events throughout the year, and the signatures include famous tennis players from around the world and President Dwight D. Eisenhower.
Lawrence Phipps came to Denver from Pittsburgh, after retiring as a vice president of Carnegie Steel. Already a multi-millionaire in his mid-30s, he is said to have come to Colorado to "invest in health and happiness." He married Margaret Rogers, with whom he had two sons, Gerald and Allen. Lawrence C. Phipps, Jr., from a previous marriage, moved with his father from Pennsylvania to Colorado.
Lawrence C. Phipps died in 1958. Margaret Rogers Phipps gave the Tennis Pavilion to the University of Denver in 1960 and then, with the concurrence of her sons, gave the mansion in 1964.
The opening gala, Fabulous 50 at the Phipps, also marked the JSG's golden anniversary. Gala chairs were Carol James and Jane Wilson; Evelyn Wright, Sarah Omer, Andrea Kirchhoff and Jane Koerbel were the Showhouse chairs.
Twenty past presidents were at the gala, as were 19 of the 33 women who had served as Showhouse chairs over the years.
Amy Blumental, who has worked on at least 20 Showhouses, flew in from her home in Charlotte, NC, to join in the festivities, while Scottie Button was there from Superstition Mountain, Ariz., and Linda Duncan traveled from Mableton, Ga.
It was a bittersweet night for Marie Belew Wheatley, who'd been married at Phipps Mansion 10 years to the day of the opening gala; sadly, her husband had died just weeks before the big night.
Past presidents there included Mary Lou Walters, Glenda Richter, Barbara Uhrich, Joan French, Linda Diekvoss, Michelle Austin, Linda Holben, Marla Gentry, JoAnn Gadkowski, and Chris Agnew.
Ann Cole, who'd chaired the most succesful Showhouse, the Highlands Ranch Mansion, in 1986, had fun reminiscing with such other past leaders as Gail Berliner (1978), Mari Fountain (2004), Denise Sanderson (1993) and Linda Bryant (2002).
The guild's public relations chair, Marcia Norman, loaned the gown she had worn for her 1951 wedding, to the cause. It was used to decorate the newly refurbished bride's room.
Pam Kelker was glowing from the numerous kudos she was receiving on the Herculean effort she put in re-doing the tennis court area; ditto for Richard White of HW Home, decorator for the balcony overlooking the indoor court.
"For a while, it looked like we might not have a Showhouse this year," Jane Wilson said. "But with this being the guild's 50th year, the members said this wasn't the year to put the project on hiatus."
Pure chance is how the Tennis Pavilion was selected. "I'd come out here to check it out as an event rental and immediately saw that it needed us," she said. "So we lined up some decorators, who painted and sanded and cleaned before bringing in their merchandise; Marla and Dick Gentry donated drapery fabric from their Wesco Fabrics, and before long, the pavilion had its much-needed facelift."
Others enjoying champagne and a Footers Catering buffet: Jim and Kate Taucher, Bob and Kathleen Reginelli, Tom Jensen, Sonny and Pam Wiegand, Lisa Merritt, and JSG president-elect Christine Thomas with hubby David.
Denver Post Society Editor Joanne Davidson can be reached at 303-809-1314 or email@example.com.
Pictures from the opening night gala can be viewed at www.denverpost.com/seengallery


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August 22, 2013
Upcoming August Meeting
Hey all! It's time again for our monthly meeting! At this month's meeting we will be sharing the results of the design challenge that was held at last month's meeting - I hope you all have your blocks finished! I will also be leading a tutorial for a nifty way to cut bias binding. You will need to bring:
Fabric (as little as a FQ)
Rotary Cutter
While the workroom does have rotary cutters and rulers available, there will probably not be enough to go around while I am doing the tutorial. Bring your own if you can and be sure to clearly mark them with tape or something so that nothing gets mixed up.
As always, please bring along your completed projects and/or problems to share with the group.
For those members who have not paid their dues, please be sure to bring along cash on Sunday. If you do not pay your dues at this month's meeting, you will not be able to participate in the next fabric challenge organized by the MQG.
As you all know, Quilts at the Creek happened earlier this month. I was there on Saturday; were you able to make it? I took pictures of all of the quilts that I knew were made by members (sorry if I missed anyone) and will be writing a blog post about it soon.
Subscribe to: Posts (Atom)


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Tinsel Korey Gossip
Tinsel Korey gossip, latest news, photos, and video.
Wolves are pretty
Those vampires with their pasty faces and Walmart wigs vs the healthy natural beauty of the wolves – based purely on aesthetics, I am of the lupine persuasion. These are members of the pulchritudinous Quileute Nation out and about Vancouver recently– young BooBoo Stewart with a new haircut, Chaske Spencer and the rarely seen and very beautiful Tinsel Korey. Full Story


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Wow, what a whirlwind trip! We got back last night from our trip to Cleveland for my taping of Quilting Arts TV. I was totally nervous, but my dear friend Amy went with me and really helped calm my nerves. Plus she took lots of pics for me, including the one of me on set above. That's me behind the table!
And this one of me in make-up. I honestly don't think I have ever worn so much make-up in my life. I'm a pretty simple girl, and Amy swore that I looked fine, but I felt like I had plaster on my face and raccoon eyes. The make-up artist was really great though, so I'm sure I was in good hands.
And this is another reason why Amy rocks. She brought a big stash of nail polish so we could have manicures in our hotel room on Sunday night. We laughed and laughed at some crazy shows on Food Network while we painted our nails. Ah, a girls' night out for two moms of young children--and it felt so weird to not have anyone to take care of!
Amy took a lot more photos, although I haven't had a chance to even look at them yet. But I'm sure I'll have some more fun ones to share of my Quilting Arts TV adventure soon!


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Location: Pavilion
From: Thursdays & Fridays, 6:00-7:30am
The Breakfast Program, formerly known as the Caring Committee Feeding Program, is among Central Synagogue's longest ongoing social justice projects. Originally conceived and implemented by longtime congregant Nat Shapiro in 1983, the Breakfast Program was started in response to Mayor Koch's outcry for New York City's religious institutions to respond to an exploding homeless and hungry problem. Today, many clients of the Breakfast Program are working poor who greatly appreciate and regularly rely on the warm, nutritious start to their day. Volunteers assemble every Thursday and Friday morning in Lese Lobby (Community House) to prepare and serve the most important meal of the day. A bag lunch is also handed out to clients. These lunches are prepared the prior evening as part of Central Synagogue's Sandwich Making Program. Volunteers must be in the 6th grade or older; those under the age of 18 must be accompanied by an adult.
Location: Community House, room 503
From: Fridays | 8:15-9:15am
Explore one of the most radical rabbinic texts in all of Judaism, the Babylonian Talmud. The class will delve into the Talmudic texts that serve as a paradigm for Jewish innovation and rabbinic creativity and we'll use them to discover the profound roots of our modern-day faith.
Location: Community House
From: 5:00 pm - 6:00pm
Families with Children ages 0-5 • Open to All • No RSVP Required
Shabbat Central, formerly known as Tot Shabbat, provides a warm, exciting, and accessible Shabbat experience for your entire family. Geared to families of children from birth to age five, Shabbat Central is led by an experienced musician and children's service leader along with members of the Family Engagement department and Early Childhood department staff. Children and families gather together for song, prayer, movement, stories, and fun. Following the service, a light meal is served.
Open to all – no RSVP required.
For a complete list of dates, visit the Shabbat for Kids & Families page.
Any questions? Contact Amy Martin.
Your tax-deductible contribution to our Annual Yom Kippur Appeal will provide for Central's exceptional educational, community, and spiritual programs and help enrich the Jewish experience of our members and the community-at-large.


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Some of your body's cells have a 'license to kill'
Millions of "natural killer cells" -- nature's first line of defense against cancer, viruses and other infectious microbes --- are on constant patrol inside your body.
These tiny assassins, the immune system's rapid-response team, can quickly spot a dangerous cell, poke holes in its outer wall and release poisons to destroy it. They also alert other immune cells to join the attack.
Despite their forbidding name, natural killer cells are the good guys in the never-ending war against disease.
Like some espionage agents, NK cells have a "license to kill," according to Wayne Yokoyama, an immunologist with the Howard Hughes Medical Institute at Washington University in St. Louis. The "license" is a molecular tag that allows a killer cell to whack a bad cell.
Although NK cells were discovered more than 30 years ago, they're still not well understood, and they remain an active field of research. Scientists are trying to figure out how killer cells "see" a target cell, how they tell whether it's infected or healthy and how they carry out their lethal task.
"We remain puzzled about where and when NK cells develop," James Di Santo, the director of the immunology department at the Institut Pasteur in Paris, acknowledged in the journal Nature Immunology. "We still have many questions."
"We have gained only a partial understanding of how NK cells recognize a target cell as friend or foe," Michael Caligiuri, a professor of cancer research at Ohio State University, wrote in the journal Blood.
Caligiuri said researchers hope "the immune system can be engineered to cure some forms of cancer." Other potential targets for possible vaccines, treatments or cures are HIV, viruses that cause hepatitis and herpes, and various bacteria, fungi and parasites.
Some patients received NK cells in preliminary clinical trials in the 1980s, but the tests were abandoned, partly because of toxic side effects.
"We're still in early stages," Yokoyama said. "As we know more about how they work, we'll do better."
Recent advances in NK research include:
• The discovery by Yokoyama and other scientists that NK cells can "remember" a previous infection and respond more rapidly to a second attack.
"Once they've been activated, they can respond more easily and effectively to the next call for activation," Yokoyama wrote in the Jan. 30 issue of the Proceedings of the National Academy of Sciences.
• A possible method to make NK cells even more deadly executioners.
Andre Veillette, a cancer researcher at the Clinical Research Institute of Montreal, has identified a molecule, named CRACC, on the surface of NK cells that he said "augments their ability to kill abnormal cells."
A drug that stimulates CRACC would "increase their killer function," Veillette said.
NK cells are being generated constantly in bone marrow. They prowl through the blood and lymph systems, searching for signs of infected or cancerous cells. When they find one, they latch on to it and attempt to execute it, leaving nearby healthy cells alone.
If an NK cell can't find a certain protein complex, called MHC-1, which is normally on the surface of a target cell, the target is doomed. If the protein is present, however, the diseased cell is spared.
This ability to distinguish between friend and enemy "ensures that NK cells effectively carry out their surveillance function by leaving most cells undisturbed while being ready to destroy cells that are diseased," Di Santo said.
Another strength of NK cells is their quickness. "NK cells are able to deliver a response immediately after recognizing specific signals from molecules of foreign origin," said Jordan Orange, an immunologist at the University of Pennsylvania.
Other parts of the immune system, so-called B and T cells, are more numerous and powerful than NK cells but slower to react to an infection.
"It takes many days for that to happen," Yokoyama said. "NK cells, though there are less of them, can initiate a large response very early."
"More work is required to realize the dream of harnessing NK cell-based therapies in the clinic," Di Santo said. "Ultimately, we can hope that unraveling the mysteries of how these (NK cells) function will have an impact on human disease therapies."
(c) 2009, McClatchy-Tribune Information Services.
Visit the McClatchy Washington Bureau on the World Wide Web at www.mcclatchydc.com>


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Ordinarily we have a do-not-treat-"viral"-advertising-like-it-is-news policy. But according to the official hierarchy of Deadspin editorial policies, the everything-even-tangentially-involving-Rob-Gronkowski-is-news policy trumps the one I mentioned in the last sentence.
So with that disclosure out of the way, please enjoy Rob Gronkowski's homemade video campaigning for the Madden 13 cover. You can tell it's actually homemade, and not shot in some studio designed to resemble a home, because of the fuzzy carpeting and the convertible sofa from Bob's and the walls unadorned but for a Fathead and the prefab sheen of the doors. No set designer would ever produce a room this cheap. Yo soy frugal!
Via CBS Sports, h/t Scott.


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Your Account
Windows Developer Power Tools
by James Avery, Jim Holmes
December 2006
Print: $59.99
Ebook: $47.99
"What I found most pleasing about this book, is the consistency in which it presents each topic for you. The authors has gone to great length to make it a flawless experience in reading this book and even though many has contributed to the content, the layout is flawlessly simple. A very easy read and a bookshelf essential! "
--Brian Madsen, .NET Powered by Caffeine
"Until reading this book, I did not realize how much productivity I stood to gain...When I first agreed to review this book I didn't know what I was really getting into. I expected a brief catalog of fairly standard, well-known tools which would only come as a surprise to fresh graduate. I expected I getting a small pocket-sized book which I could devour in one train ride. I could not have been more wrong.
The book covers over 170 Open Source tools across a wide variety of development domains from Windows Forms and Web Development, to working with Databases and XML data. Each tool will in some way enhance your productivity in some way, allowing you to do the things your really enjoy about writing software on the Microsoft Windows platform. The productivity gains vary from being able to generate the tedious 80% of your project to those 5 second boosts which all add up and prevent RSI."
--Michael Minutillo, Wolfbyte .NET
"...there is a boat load of tools available out there in the wild, and it's hard to decide which one could be useful for us, and this book does a great job at pointing us out to what's worth checking out."
--Claudio Lassala, Windows Live
"Looking for the right tool for the job at hand is often an arduous process usually involving the comparison of similar tools and cost. It would be nice to have a reference to some of the most widely used tools available and an understanding of what makes the tool beneficial to you. This is where the Windows Developer Power Tools book can help enormously. Created by James Avery and Jim Holmes (both Microsoft MVPs with a wealth of experience), the book introduces you to over 170 tools that are either free to use or published under various open source licenses. Although the title of the book may suggest that it concentrates on Windows Development, don't be fooled, it contains many tools and components for ASP.NET developers plus tools that will help you document, debug and profile your applications...The book is extremely well laid out and offers good insights into the tools that you need to get your job done. The amount of time saved looking for the right tool and the information and instructions provided for each tool easily covers the cost of the book. If you like your toolbox to contain the best tools of the trade, then this book is definitely for you. "
--David Jeavons, DevCity.NET
"Windows Developer Power Tools by James Avery and Jim Holmes effectively points out nearly 170+ interesting tools along with relevant explanation regarding the usage of each one of them...Overall, I feel that the book is a good reference material for developers as it will surely benefit them someday."
--Anand Narayanaswamy, ASPalliance
© 2020, O'Reilly Media, Inc.
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All trademarks and registered trademarks appearing on oreilly.com are the property of their respective owners.


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North Korea's leader has warned of an "all-out" war against the South while denouncing its ongoing joint military drill with the United States, state media said today.
The US and South Korean militaries on Monday began a two-week exercise aimed at testing defences against the communist North, insisting it was defensive in nature but Pyongyang called it a drill for a preemptive nuclear attack.
More than 30,000 US troops, including most of those based in the South plus 3,000 from overseas, are taking part in the annual joint drill known as Ulchi Freedom Guardian.
North Korean leader Kim Jong-un called the drill a grave threat and said his army was ready to deal "deadly blows" if their territory was violated during the exercise.
"If the enemies fire even a single shell on our inviolable territory... the whole army should turn out as one and lead the battle to an all-out counter-offensive," said the leader, according to KCNA news agency.
The courageous officers... are now waiting for a final order for charge for a life-and-death battle against the enemies," Kim was quoted as saying in a speech to army officials yesterday. "There is a limit to our patience."
Kim, believed to be in his late 20s, took over the impoverished but nuclear-armed nation after his late father and longtime ruler Kim Jong-Il died last December.
On the eve of the ongoing drill, the young leader visited a frontliner artillery unit that carried out a deadly 2010 bombardment of a South Korean island near the disputed western sea border.
Kim praised its personnel as heroes and told them never to tolerate enemy aggression.
The two Koreas have remained technically at war since their 1950-53 conflict ended in an armistice, without a subsequent peace treaty.
Cross-border tensions have been high since the South accused the North of torpedoing one of its warships with the loss of 46 lives in March 2010.
The North angrily denied involvement but went on to shell the Yeonpyeong island in November of the same year, killing four South Koreans including two civilians.


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Eastern Sierra Fish Report
Walker River - East Fork (CA) Fish Report for 8-29-2015
Walker River - East Fork (CA) Fish Report for 8-29-2015
East Walker River Fishing Report
Walker River - East Fork (CA) - Bridgeport, CA (Mono County)
by Nor Cal Fish Reports
Water Conditions: Poor
Flows are at 20cfs as of 8/27
Haven't had any reports. Last we heard most of the fish moved downstream. It's anybody's guess now. Give us a call for the latest information.
Flows are at 20cfs as of 8/27
Haven't had any reports. Last we heard most of the fish moved downstream. It's anybody's guess now. Give us a call for the latest information.
< Previous Report Next Report >
< Previous Report Next Report >
More Reports
Nor Cal Fish Reports Reportsfor Wednesday, August 26th, 2015
Lake Almanor: Slow for most at Almanor
Lake Amador: All quiet at Amador
Anderson Reservoir: Good shoreline bite at Anderson
Lake Berryessa: Good bass, scattered koke bite at Berryessa
Bullards Bar Reservoir: Cats biting at Bullards
Calero Lake: Good bass bite at Calero
Lake Camanche: Cats biting at Camanche
Caples Lake: Caples in good shape
Lake Chabot: Chabot cats biting better
Clear Lake: Clear Lake bass strong
Collins Lake: Collins cats lurking
Contra Loma Reservoir: Little action at Contra Loma
Coyote Lake: Bass hit surface lures at Coyote
Del Valle Lake: Stripers boiling at DV
Donner Lake: Donner bite hanging on
Indian Creek Reservoir: Slow shore bite at Indian Creek
June Lake Loop: Boomer brown hooked at June
Lafayette Reservoir: Final catfish plant goes in Lafayette
Lewiston Lake: Moving water aids Lewiston
Lopez Lake : Big bass, cats at Lopez Lake
Los Vaqueros Reservoir: WInd slows, bite improves at LV
Mammoth Lakes : More trout planted in Lakes Basin
Lake McCloud: Hot bite at McCloud Reservoir
Lake Mendocino: Crappie, cats bite at shrinking Mendo
New Melones Reservoir: Cats best at New Melones
Lake Oroville: Tough access, tough bite at Oroville
Prosser Reservoir: Smallmouth active at Prosser
Quarry Lakes: Nothing happening at Quarry Lakes
San Luis Reservoir: Dog days at San Luis
San Pablo Reservoir: Warm water, slow bite at San Pable
Santa Margarita Lake: Fair prospects at Santa Margarita
Shasta Lake: Shad schools attract Shasta fish
Lake Sonoma: Slow bassing at Sonoma
Carson River - East Fork (CA): East Carson well stocked
Klamath River - Upper - CA: Jacks hit the Klamath
Napa River: Solid striper bite on Napa River
Sacramento River: Colusa salmon elusive
Sacramento River: Rumors of Butte County salmon
Trinity River: Waiting for main run of Trinity salmon
Sacramento Delta: Antioch striper bite keeps going
: Salmon numbers improving in Benicia
Discovery Bay: Little stripers in Disco Bay
Sacramento Delta: Black bass slow, stripers OK in Franks Tract
Sacramento Delta: Big zip in Freeport
Sacramento Delta: Pittsburg full of small striper
Sacramento Delta: No salmon, improving stripers in Rio Vista
Sacramento Delta: Stockton striper action picking up
Sacramento Delta: Big bass, lots of cats in Tracy
: Cod bite best in Capitola
: Few salmon, lots of cod in Crescent City
: Eureka boats heading south
: Salmon on uptick in Fort Bragg
: Night bite for Pacifica stripers
: Bay salmon bite tepid
: San Pablo bay full of small stripers
: Salmon bite ON in Trinidad
Nor Cal Fish Reports Reportsfor Wednesday, August 19th, 2015
Lake Almanor: Hamilton Branch the bright spot at Almanor
Lake Amador: Amador full of bluegill
Anderson Reservoir: Anderson closed to boating
Lake Berryessa: Berryessa bass bite good, koke bite fair
Calero Lake: Calero remains open to boats
Lake Camanche: Catfish biting at Camanche
Lake Chabot: Slow going at Chabot
Chesbro Reservoir: Crappie biting at Chesbro
Clear Lake: Jigs, crank baits work at Clear Lake
Collins Lake: Collins cats biting
Contra Loma Reservoir: Cats biting at Contra Loma
Convict Lake: Convict pushing out big trout
Coyote Lake: Good bass numbers at Coyote
Del Valle Lake: Cats, smallies biting at Del Valle
Donner Lake: Nothing easy at Donner
June Lake Loop: Mixed results at June Loop
Lafayette Reservoir: Heat takes toll at Lafayette
Lexington Reservoir: Take minnows to Lexington
Lewiston Lake: Lewiston clearing
Lopez Lake : Warm water fish biting at Lopez
Los Vaqueros Reservoir: LV stocked for the future
Mammoth Lakes Basin: Lakes Basing gets more big trout
Lake Mendocino: Mendo boat ramps closed
New Melones Reservoir: Catfish best option at New Melones
Lake Oroville: Launching biggest Oroville challenge
San Luis Reservoir: Bait gets San Luis stripers
San Pablo Reservoir: Slow bite at San Pablo
Santa Margarita Lake: Good crappie bite at Santa Margarita
Shadow Cliffs Reservoir: Cats biting at Shadow Cliffs
Shasta Lake: Find cool water for Shasta bass
Shaver Lake: Shaver Lake on fire
Stampede Reservoir: Stampede slowing
Lake Tahoe: Good action at Tahoe
Uvas Reservoir: Uvas cats willing
Whiskeytown Reservoir: Nothing easy at Whiskeytown
Carson River: East Carson due for a plant, West too low
Feather River: Feather light on salmon
Klamath River - Upper - CA: Lower Klamath ready for fresh salmon
Napa River: Napa River striper run underway
McCloud River: McCloud fishable again
Sacramento River: Sparse pickings in Colusa
Sacramento River: Dog days in Butte County
Trinity River: Water surge inviting salmon upstream
Sacramento Delta: Antioch striper bite very good
: Stripers stopping by Benicia
Sacramento Delta: Frogs fading at Franks Tract
Sacramento Delta: Dinks invading Pittsburg
Sacramento Delta: Stripers trickling back to Rio Vista
Sacramento Delta: Stockton providing action
Sacramento Delta: Tracy putting out black bass
: Lots of cod, a few sea bass, halibut in Capitola
: Jack smelt invade Crescent City
: Eureka salmon hiding
: Fort Bragg rock cod biting
: Bottom fishing in Monterey spotlight
: Stripers moving offshore from Pacifica
: Stripers moving into San Pablo Bay
EasternSierra.FishReports.com © 2020. All Rights Reserved.
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text:
This site is the archived OWASP Foundation Wiki and is no longer accepting Account Requests.
To view the new OWASP Foundation website, please visit https://owasp.org
Saudi Arabia
OWASP Saudi Arabia
Welcome to the Saudi Arabia chapter homepage. The chapter leader is Amro Ahmed
<paypal>Saudi Arabia</paypal>
OWASP Foundation (Overview Slides) is a professional association of global members and is open to anyone interested in learning more about software security. Local chapters are run independently and guided by the Chapter_Leader_Handbook. As a 501(c)(3) non-profit professional association your support and sponsorship of any meeting venue and/or refreshments is tax-deductible. Financial contributions should only be made online using the authorized online chapter donation button. To be a SPEAKER at ANY OWASP Chapter in the world simply review the speaker agreement and then contact the local chapter leader with details of what OWASP PROJECT, independent research or related software security topic you would like to present on.
to this chapter or become a local chapter supporter. Or consider the value of Individual, Corporate, or Academic Supporter membership. Ready to become a member?
Local News
Our next event will focus on auditing application systems development
Location Venue: Makarim Hall - Marriott Hotel City : Riyadh - KSA Date: 2nd March 2009 Time: 08:30 - 15:00
Seminar Agenda
08:30 – 09:00 Registration Team 09:00 – 09:30 Introduction 09:30 – 10:20 PCI (Applications Firewalls/SSL VPN) 10:20 – 10:40 Refreshment 10:40 – 11:20 Case Study 11:20 – 12:10 Application Delivery Controller 12:10 – 12:40 Prayer 12:40 – 01:00 Last Session + Questions +Closing Session 01:00 – 02:00 Lunch
Peter Draper, Security Specialist: has been providing guidance, design and implementation of Info Sec solutions for some 17+ years. The last ten years have been focused on Application delivery and security with the most recent focus following the main hacking attempts into the Web Application Security space. Peter has been instrumental in delivering Web Application Security into a wide and varied range of customers including finance, government, ecommerce and travel industry companies. Within the Middle East region Peter had delivered solutions to Government, Finance and Corporate customers ensuring the best possible protection is in place to secure customer sensitive data.
Peter's presentation will focus on:
1) What is the "PCI Journey"? 2) What do I need to do and when? 3) Is PCI the only reason to deploy security solutions? 4) Where should I concentrate my $ 5) What happens once I have it?
Nigel Ashworth, F5 MEA Technical Director: has been F5's Technical Director for Middle East and Africa since September 2005. In that time he has driven the region's increasing importance to F5's global business, managing the pre sales engineering team, and investing technical resources in key verticals to drive double-digit sales growth. Nigel has been with F5 for nine years in a number of senior technical roles, including Technical Director responsible for driving EMEA Strategic Alliances with key partners including Microsoft, SAP and Oracle, and Technical Director responsible for pre-sales in Europe. Prior to joining F5, Nigel held technical leadership positions for companies including Reuters and UB Networks. He received his B.S in Electrical Engineering from Portsmouth University.


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Learning to program a computer is hard. While you can learn to make useful things in a few months, mastery may take a decade. It's not like learning to bake a cake or shoot a video. It's more like learning to play a musical instrument. It takes years of practice to get really good — or in the programmer's case, tens of thousands of lines of production code. Meanwhile, you're going to make the neighbors' ears bleed.
Why would anyone do this? I think the reasons people invest such insane amounts of time in such a specialized skill are shifting. And I think that shift is healthy. It's a shift in what it means to be a technologist. And the culture of our technical communities is shifting with it.
Back then
I learned to program in high school, early 90s. Looking back, I think my formative experiences as a technologist were pretty typical for my generation of programmers. I had three or four close friends in high school who also liked computers. They were all male. This was the dawn of the internet, around the time of the very first web browsers, and long before the first tech bubble made geeks into rich visionaries. We were not remotely cool. Technical information was somewhat harder to come by than today, but not excessively so. My first C++ compiler shipped in a big box which included a thick paper reference manual and a really nice language tutorial. We subscribed to Byte and Doctor Dobbs' Journal. We hacked on stuff at lunch time and after school and weekends, and traded shareware on floppies. The technology was different, but the substance of the experience was much the same as today. We spent a lot of time at the computer, and we were well-connected into a community of like minded people. The community provided technical help but also motivation and inspiration.
We weren't trying to change the world. We were driven by an intense curiosity about the inner workings of machines, and we wanted to be admired for being good at something. I wrote the Windows port of Netrek, one of the very first multiplayer online games, and the local geeks knew who I was when I arrived at the University of Toronto. This kind of experience persisted through my undergraduate years studying computer science. Long nights in the computer lab; cool hacks. There's a wonderful book which captures this culture as it evolved starting in the late 1950s.
Enter women
There were no women in the communities where I learned to program. Or, almost none. I did a head count in one of my classes: four out of 150 students. Sadly, this kind of ratio persists today in many technical fields. I didn't really know why this was. Us nerdy boys would have welcomed geeky girls. For all sorts of the right and wrong reasons.
It's only in the last few years that I've started to understand why the dominant nerd culture drove women away in droves. Simply put: it was a club full of very poorly socialized boys, and our peer-based motivation was all about status. We all wanted to be the alpha geek. We would jump all over each other to point out errors. We would never miss a chance to demonstrate our superior, elegant technical minds. We were completely insufferable to anyone else.
Fortunately, there are now more women in tech. And they're starting to tell their tale. While I don't want to generalize too much from the experiences of a single person, I found the account of Rebekah Cox to be really enlightening (there are lots more great stories in the same thread):
So, if you enter this environment as a woman without any sort of agenda or understanding of this culture the first thing you find is that if you actually say something the most likely reaction is for a guy to verbally hit you directly in the face. To the guys this is perfectly normal, expected and encouraged behavior but to women this is completely out of nowhere and extremely discouraging.
As a technical woman, this is your introduction and the first thing you have to learn is how to get back up and walk right back into a situation where the likelihood of getting punished for participating is one. How you choose to react to this determines the rest of your career in technology.
Now, I don't want to give the wrong impression. It wasn't all one-upmanship and verbal assaults. These geek scenes could also be wonderfully supportive, and often served as social groups too. You have to remember that this was before computers were cool, and it was an awkward adolescence when you were interested in things you couldn't begin explain to anyone else. Also, it was a great learning environment. Cox again:
Even the aforementioned nerd trash talk is actually a useful tool that can help you. The reason that culture exists is to make everyone in the group better. The fact that you are getting hit in the face means that someone is either wrong and you can hit back with a correct answer or that you are wrong and someone is letting you know that directly. Sticking that out means you are learning in an accelerated environment with instant correction.
Furthermore, if you stick around long enough, you can find people who aren't completely insecure and are confident enough to not resort to insults to assert themselves. Those people make the tough environment actually tolerable. If you can help each other then you can establish a safer zone to talk through ideas. And since those more secure people are typically so secure because they are really, really good, you can find yourself in an informational jet-stream.
In this artificial high-pressure environment we got good fast. But it was certainly off-putting to women, and not just women. Lots and lots of people wanted no part of this, and for good reason. Yet for quite a long time it was these sorts of socially dysfunctional communities that produced the lion's share of the best technologists.
Why program?
Learning to program is still ridiculously hard, and still requires a community of practice. And it still requires an absurd focus and motivation. But the sources of that motivation are broadening. I've been watching this shift for a while. The notion of programming for the social good has even crystalized into institutions such as Random Hacks of Kindness (for international development), Hacks/Hackers (for journalists), and Code for Amercia (civic platforms.) For that matter, there's Wikipedia. There are services and data all over the web. We don't have to wonder whether software can change the world — it already has!
So by my old-school standards, the burgeoning hackers of today are very applied. I grew up desperately curious about the insides of things. Many of the programmers getting started now are far more extroverted than that. Here's MIT Media Lab fellow Lisa Williams:
I want to learn to code because a lot of things piss me off.
I believe a program can stand in opposition to Things That Suck, just like a documentary, a work of art, or a protest march.
I wanna code because SHIT IS BROKEN. I want to code because corruption is real, because people are getting thrown out of their houses, because veterans aren't getting what they deserve, because racism is real and has real effects, because yes it does matter when you cancel a bus line, because it's really hard to shut a computer program up, because you can't say it's an isolated incident when there's a bigass Google Map in your face showing you it's not.
This is Lisa demanding "computational journalism." But pretty much every field of human endeavor uses lots and lots of software now. Software not only determines what is possible, in many ways, but what is not possible: code-as-law. It's part of the system, and if you want to hack the system, well, at some point someone has to hack the code. That person could be you.
At the Online News Association conference last week, I ran into Michelle Minkoff and Heather Billings standing in front of couple dozen enthusiastic young journalists who had gathered in the hallway to hear about programming. Michelle works with me in the Interactive department at the AP, while Heather just started at the Chicago Tribune. Both are fearsome technologists, though I don't think either would be offended if I said they are still near the beginning of their journey. That makes them the perfect people to talk to about learning to program.
Most of the people attending had some programming experience, but not much. There were 24 people listening to Michelle and Heather, 9 of whom were female. A great improvement. I sat in on this conversation for a while. It wasn't what I was expecting. No code. Very little technical discussion at all actually. One woman said she knew enough Python to write a Hangman game. "Great!" said Michelle. "You're ready to learn Django!"
I guess I'm surprised anyone has to be told that they are ready to learn to program. But inclusion and connection was a major theme in the discussion. Here are some of the snippets of conversation I wrote down:
"You can make an anonymous account on StackOverflow and ask stupid questions."
"Connect in person, build that mentor relationship."
"But that documentation is for developers!"
This was a group of people who needed to be told that they could learn to program. That they could be one of them. This is understandable. When you can't begin decipher the supposed "instructions," technology can seem like an occult priesthood. But you don't need them. You just need to want to do it, really badly, and you need to find some other people who want to do it badly too (and obviously, expect to meet these people online.) Then one of them becomes one of us. Of course you can learn to program. It just takes a while, and a stupid amount of practice.
In fact it's probably necessary to devote a few years of your life to it full time. That's one of the advantages of a computer science degree — time to focus. Also, a CS degree is a fast track to the deep theory of computation; if you find yourself looking at programming languages and asking why they are the way they are, or staring hungrily across the awesome gap between your web apps and a search engine, you probably want to learn computer science, and formal education is one way to do that. But CS theory won't make you a programmer. Only programming will do that.
Every truly good programmer I have known had some period of their life where they thought of nothing but code. Something around a year or two. It's got to get under your skin at some point. I call this the hacker gestation period. You'll know you've reached the other side of it, because software will stop being mysterious. Eventually code becomes clay.
And this formative period is why it's so important to have a community. You're going to need friends who are interested in talking about geeky stuff. You'll be so excited about it for a while that you won't be able to talk about much else. (Really. If this is not the case, go do something else. Programming takes so much soul that you're going to hate your life if you don't genuinely enjoy it.) Your community will help you when you get stuck, and they will help you develop your sense of style. Code is the most obscure art, because only another programmer can see all the layers of beauty in a truly lovely piece of code. But it's very hard to become an artist alone, without influences and critics.
So it takes a village to make a programmer. I won't say that our technical villages are now inhabited by "normal" people, by any stretch of the imagination, but the communities where programmers are now growing up seem far more diverse, supportive, and extroverted than in years past.


text:
Think of a number, add one, double it, take away 3, add the number you first thought of, add 7, divide by 3 and take away the number you first thought of. You should now be left with 2. How do I. . . .
Here are three 'tricks' to amaze your friends. But the really clever trick is explaining to them why these 'tricks' are maths not magic. Like all good magicians, you should practice by trying. . . .
Choose any four consecutive even numbers. Multiply the two middle numbers together. Multiply the first and last numbers. Now subtract your second answer from the first. Try it with your own. . . .
Take any four digit number. Move the first digit to the end and move the rest along. Now add your two numbers. Did you get a multiple of 11?
This jar used to hold perfumed oil. It contained enough oil to fill granid silver bottles. Each bottle held enough to fill ozvik golden goblets and each goblet held enough to fill vaswik crystal. . . .
Make a set of numbers that use all the digits from 1 to 9, once and once only. Add them up. The result is divisible by 9. Add each of the digits in the new number. What is their sum? Now try some. . . .
Choose two digits and arrange them to make two double-digit numbers. Now add your double-digit numbers. Now add your single digit numbers. Divide your double-digit answer by your single-digit answer. . . .
This Sudoku requires you to do some working backwards before working forwards.
A brief article written for pupils about mathematical symbols.
Read this article to find out the mathematical method for working out what day of the week each particular date fell on back as far as 1700.
Can you arrange these numbers into 7 subsets, each of three numbers, so that when the numbers in each are added together, they make seven consecutive numbers?
If you would like a new CD you would probably go into a shop and buy one using coins or notes. (You might need to do a bit of saving first!) However, this way of paying for the things you want did. . . .


text:
Electrical Stimulation of the Sphenopalatine Ganglion for the Treatment of Migraine Headaches
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01294046
Recruitment Status : Completed
First Posted : February 11, 2011
Results First Posted : March 7, 2017
Last Update Posted : April 14, 2017
- Study Details
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
This investigation will gather information about a procedure called sphenopalatine ganglion (SPG) stimulation, and its appropriateness, safety, and efficacy as a treatment for those who suffer migraine headaches which may result in chronic severe disability. The SPG is a small collection of nerve cells in the head, and is located near the base of the nose on either side. Participation involves the surgical implantation of an electrode (small electrical conductor) over the sphenopalatine ganglion. The electrode is connected to a stimulator which will enable treatment for migraine headaches. Tiny electrical current is delivered to the stimulator device by an internal pulse generator implanted in the area at the top of the chest, to stop the migraine headaches. The implant system will be controlled with a wireless remote provided after the implant procedure.
Participation will record headache diaries throughout the study, which will last approximately 8½ months, and a yearly visit annually for five years.
|Condition or disease
|Migraine Headache
|Device: Deep Brain Stimulation of SPG for Migraine
|Not Applicable
This application proposes a clinical study of electrical stimulation of the sphenopalatine ganglia (SPG) as a treatment for up to three individuals with episodic migraine headache. The present study is aimed at obtaining pilot data to guide a future controlled trial of this treatment modality. The study population will include individuals suffering from episodic migraine headaches with chronic severe disability, as demonstrated by the Migraine Disability Assessment Questionnaire (Lipton, 2000) and Headache Impact Test short form (HIT-6™) (Kosinski, 2003).
The treatment involves implantation of an electrode into the SPG. The electrode is connected subcutaneously to an infraclavicular stimulator (PrimeAdvanced™ 37702 Multi-program Neurostimulator System, Medtronic Inc., Minneapolis MN). Proper electrode placement will be verified using anatomic and physiologic techniques. Participants will receive the Medtronic Model 3389 or 3387 lead, or Medtronic subcompact lead Model 3776-45, 3776-60, or 3776-75. Stimulation will be delivered in a range of frequencies from 20 to 130 Hz, and pulse width from 60 to 450 μsec, and a titrated voltage. The voltages used for chronic stimulation may range up to the pulse generator maximum of 10.5 volts but are anticipated to generally be below 3 volts, keeping below the 30 µcoulomb/cm² charge density safety limit, and below the threshold for adverse stimulation-related effects. The minimum number of contacts on the quadripolar leads will be activated as necessary to produce a response.
The Prime Advanced neurostimulator to be used in this study allows the clinician to set all stimulation parameters including the maximum allowable amplitude. It is our responsibility to assure that appropriate stimulation parameters are used to result in appropriate electrical exposure charge density) below a 30 µC/cm2/phase limit. As is done with commercially available neurostimulators, during this study, we will utilize the charts presented in Figures 1 and 2 below to assist in selection of programming parameters, and this programming will be maintained by software controls within the neurostimulator.
For this exploratory study of 3 patients, the maximum electrical stimulating parameters, resulting electrical exposure (e.g., charge density), will be determined using the methods described above. It is our responsibility to assure that safe stimulation parameters are used at all times and that the maximum settings do not exceed the safety limits. Our plan is to begin with lead 3776 if possible, because it does not require an extra extension, but we would use 3387 or 3389 if clinically indicated.
The proposed study is a physician-sponsored research investigation of three patients, and the attention to stimulation parameters will be much greater than can be expected for a commercially released product. It is our responsibility within this investigational study to insure the selected stimulation parameters do not exceed the safety limit of 30μC/cm2/phase. Patients participating in the study will only be able to lower stimulation amplitudes, thereby keeping stimulation parameters BELOW any clinician set maximum. The only programs available to or accessible by the patients will maintain the previously described parameter set limitations. Thus, the programming of the Implantable Programmable Generator (IPG) will keep the three patients from stimulating outside or above the set and safe parameters.
The primary outcome measures for assessing the efficacy of migraine treatment will be a subject reported daily diary noting frequency and intensity of headaches. During this investigation we will obtain preliminary controlled data on the safety and efficacy of SPG stimulation for migraine treatment.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|3 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Electrical Stimulation of the Sphenopalatine Ganglion for the Treatment of Migraine Headaches
|Study Start Date :
|March 2011
|Actual Primary Completion Date :
|March 2014
|Actual Study Completion Date :
|March 2014
Experimental: Deep brain stimulation of SPG for migraine
Electrical SPG for Treatment of Migraine
Device: Deep Brain Stimulation of SPG for Migraine
Deep Brain Stimulation of SPG for Migraine
Other Name: Medtronic 37702 PrimeAdvanced™
- Migraine Relief at 2 Hours Post Stimulation [ Time Frame: 8.5 Months ]Pain is rated at stimulation and 2 hours after stimulation initiated based on four point categorical scale, FDA-approved, where 0 = no headache pain, 1= mild pain, 2 = moderate pain, 3 = severe pain. This scale has been used since 1991 for all regulatory submission migraine protocols. Each migraine is categorized in a binary fashion as meeting the endpoint at 2 hours. Migraine relief or Pain relief is defined as moving from pain levels of 3 to 2 down to 1 or 0.
- Migraine Free at 2 Hours [ Time Frame: 8.5 Months ]Each migraine will be categorized as meeting the endpoint of migraine free if there is a reduction in the migraine grade to 0 for pain with no nausea, photophobia and phonophobia at 2 hours after initiation of stimulation.
- Pain Free at 2 Hours Post Stimulation [ Time Frame: 8.5 months ]As noted above, we are using the FDA-approved categorical scale used for all migraine regulatory trials since 1992. This is a 4 point categorical scale where 0= no pain, 1= mild headache pain, 2= moderate pain, and 3= severe pain. Pain free is defined as the subject moving from pain intensity of 2 to 3 at baseine to 0 by 2 hours after stimulation.
- Acute Migraine Medication Use [ Time Frame: 8.5 months ]During the baseline period, subjects will record their acute as-needed migraine relief medication use for each attack by drug, dose, route, and frequency. A secondary endpoint for this phase is a reduction in acute migraine medication usage for each attack for drug, dose, route, and frequency during the last month of the study as compared to the baseline month.
- Headache Impact Test (HIT-6) Compared With Baseline [ Time Frame: 8.5 months ]The Headache Impact Test -6 (HIT-6) is a validated tool for evaluating headache impact and disability across 6 domains, which will be recorded at baseline and at study conclusion.
- Migraine Disability Assessment Scale (MIDAS) at Study Conclusion Compared With Baseline [ Time Frame: 8.5 months ]The Migraine Disability Assessment Scale (MIDAS) is a validated tool that assesses how many days in the last 3 months a patient had at least 50% disability at work, home, school, or recreational activities due to migraine. MIDAS will be assessed at baseline and after study conclusion.
- Stimulation Related Adverse Events [ Time Frame: 8.5 months ]Number of Participants with Adverse Events as a Measure of Safety and Tolerability
- Average Per Subject Reduction in Migraine Days/Month [ Time Frame: 8.5 months ]During the baseline period, subjects will record the number of migraine days (as defined by the FDA-approved International Classification of Headache Disorders, 2d Edition definition of migraine with and without aura) during the month. The primary endpoint for this phase is a reduction in the number of migraine days during the last month of the study as compared to the baseline month.
- Implantation and Stimulation Related Adverse Events [ Time Frame: 8.5 months ]As noted above, we are using the FDA-approved categorical scale used for all migraine regulatory trials since 1992. This is a 4 point categorical scale where 0= no pain, 1= mild headache pain, 2= moderate pain, and 3= severe pain. Pain free is defined as the subject moving from pain intensity of 2 to 3 at baseine to 0 by 2 hours after stimulation.
- Relief of Migraine-associated Symptoms, e.g. Nausea/Vomiting, Photophobia, Phonophobia [ Time Frame: 8.5 months ]Presence or absence of nausea, vomiting, photophobia, and phonophobia will be assessed at baseline and after stimulation at 2 hours for each stimulation for each individual.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Age ≥18 years.
- Subject has onset of migraine headache occurring before age 60.
- Subject has been diagnosed with migraine headache with or without aura, according to the 2004 IHS criteria 1.1 and 1.2.
- Subject reports a HIT-6 score of >56, a MIDAS score of >20 and/or a failure of adequate and appropriate previous migraine treatment.
- Subject has carried the diagnosis of migraine for at least 6 months prior to enrollment.
- Subject has had at least three migraine headache attacks per month.
- Subject has had at least three headache days (migraine or non-migraine) per month and maintains this requirement during the baseline period on diary.
- Subject is able to distinguish migraine headache attacks as discrete from other headaches (i.e., tension-type headaches).
- Subject has the ability to read, comprehend and legibly and reliably record information as required by the protocol.
- Subject is able to provide written informed consent prior to participation in the study.
- Subject agrees to not participate in supplemental or alternative therapy during the baseline or treatment phases of the clinical study. This includes: acupuncture, spinal manipulation, TENS, and magnetic field treatments.
- Subject agrees to maintain current preventative headache medication regimens (no change in type, frequency, or dose) from baseline screening visit to the end of the Phase 2 treatment phase.
Exclusion Criteria:
- Subject currently has Medication Overuse Headache (MOH) in the judgment of the investigator or by ICHD-II criteria.
- Subject has a history of headaches days ≥ 15 per month.
- Subject has a history of trigeminal autonomic cephalalgias.
Subject has any medical condition or disorder that:
- Is considered to be clinically significant and may pose a safety concern
- Could interfere with the accurate assessment of safety or efficacy
- Could potentially affect a subject's safety or study outcome.
- Subject has had a major infection or surgery in the past month.
- Subject has undergone facial surgery in the area of sphenopalatine ganglia for cosmetic, corrective, therapeutic, or traumatic reasons.
- Subject has been treated with radiation to the face.
- Subject was diagnosed with any major infectious processes, primary or secondary malignancies involving the face that have been active or required treatment in the past six (6) months.
- Subject currently meets criteria as defined by the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) for an active major depressive episode or for active significant psychiatric disorders, including dementia, uncontrolled general anxiety disorder, psychotic disorders or uncontrolled bipolar disorder. Exclusion criteria include: suicidality, active psychosis, untreated severe depression and/ or anxiety disorder, litigation, addiction, homicidal ideation, significant Axis II disorders and untreated sleep disorder.
- Subject currently has clinically significant drug or alcohol abuse as defined by DSM-IV-TR or is unable to refrain from substance abuse throughout the study.
- Subject is currently participating or has participated in the last month in another clinical study in which the subject has, is, or will be exposed to an investigational or non-investigational drug or device.
- Subject is felt to be at risk of non-compliance (e.g. for completing the diary or maintaining a stable headache medicine regimen) in the investigator's opinion.
- Subject is woman of childbearing age who is pregnant, nursing, or not using contraception.
- Subject has had previous radio-frequency ablation of the SPG.
- Subject has had blocks of the SPG in last 3 months.
- Subject has undergone botulinum toxin injections of the head and/or neck in the last 3 months.
- Subject has an implantable stimulator or any implanted devices in the head and/or neck.
- Subject has H/O bleeding disorders or coagulopathy, or is on anticoagulation, antiplatelet, or GP IIb IIIa inhibitor medication.
- Subject has H/O malignancy or any other condition that requires MRI monitoring.
- Subject has or requires pacemaker/defibrillator.
- Subject is not suitable for the study, in the judgment of the Investigators, due to social, co-morbid psychological, and/or medical considerations.
- Subject has H/O stroke, cardiovascular disease, and/or epilepsy.
- Subject was on antipsychotic or antidepressant medications (except for migraine prevention) in the past 3 months prior to the study.
- Subject is allergic or has shown hypersensitivity to materials of the Medtronic components which come in contact with the body.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01294046
|United States, Ohio
|Cleveland Clinic
|Cleveland, Ohio, United States, 44195
|Principal Investigator:
|Stewart J Tepper, MD
|The Cleveland Clinic
|Responsible Party:
|The Cleveland Clinic
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
IDE Number : G100007
|First Posted:
|February 11, 2011 Key Record Dates
|Results First Posted:
|March 7, 2017
|Last Update Posted:
|April 14, 2017
|Last Verified:
|April 2017
|Individual Participant Data (IPD) Sharing Statement:
|Plan to Share IPD:
Episodic migraine headache
Migraine Disorders
Headache Disorders, Primary
Headache Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms


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In many ways, it was to We Have Band's advantage that they didn't release their debut album until 2010. Had they emerged in 2007, they'd have been cheaply branded as 'nu rave' and mopped up in the same fluorescent puddle as Shitdisco and Hadouken! On the plus side, their nightclub-friendly four-minute indie might have had a few more column inches dedicated to it, but probably nobody would have have wanted to write about it two years later.
Fortunately for them, We Have Band emerged too late to be too closely associated with any made-up music scene. They're no flash-in-the-pan, and their second record Ternion reminds us of that. Yes, it does have a certain ravey quality that would have made them an A&R man's dream in the not-too-distant past, but it's made intelligible by clever use of Kraut bleeps and a shadowy soulfulness which tip-toes towards chart R'n'B.
Single 'Where Are Your People?' creates this combination quite convincingly. It begins with an ambience akin to Kraftwerk's Autobahn, before getting funked up by soulless synthesised strings and Darren Bancroft's silky-yet-solid croon. It's a sound suited to strobe-lit dancefloors, but one enhanced by the disaffection in its delivery.
In fact, Ternion's downbeat tendencies are clear from the outset, as opener 'Shift' gets caught in a tangle of Hail To The Thief-style guitar and a strained electronic whirr. Likewise, the skittering beat of 'After All' is kept in its place by long, flat buzzes of synth and mumbled lyrics which by the end are being yelped from somewhere lonely and distant.
But while that track's climax is a masterclass in controlled chaos, what follows comes closer to clumsy carnage. On 'What's Mine, What's Yours', We Have Band take an everything-but-the-kitchen-sink approach, leading a twinkling space-age melody into a chorus that's overwhelmed by its techno throb. By the end, a chainsaw guitar is struggling for space alongside ringing telephones and spaceship sound effects. 'Steel In The Groove' is worse still, as its pulsing, repetitive beat is underscored by innumerable aimless synth patterns and vocal samples. Even the gripping fragility of closing track 'Pressure On' – slow-motion acid house piano, brimming bass, whispered vocals – is spoilt by more dumb sound effects that sound like lasers being fired in sci-fi movies and toy police sirens.
It's clear that We Have Band are at their best when they give their songs the arrangements that they're worth, instead of piling extra melodies and samples on top. It can all be a bit much, just as hearing nothing but bands clad entirely in neon blast air horns all became a bit much for about six months in 2007. We Have Band's strongest moments actually have more in common with a band like Metronomy than Klaxons. While Ternion doesn't have the class, flair or essential brilliance of The English Riveria, it often shows the same gift for understatement and ability to embrace the spaces in between the sounds. The problem is that it doesn't do so with much consistency, but at least it leaves us interested to hear where We Have Band will go next.
6Robert Cooke's Score


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STLR Link Roundup – April 9, 2010
The latest on the STLR radar: The British Parliament has approved a law authorizing temporary suspension of internet access for those accused of repeated copyright infringement, reports the New York Times. Opponents of the law, such as the Open Rights Group, promise to turn this into an election issue in Great Britain. Canadian company Wi-Lan has filed suit in the Eastern District of Texas against 19 high-tech companies—including heavyweights Apple, Dell, Motorola, Acer, and others—for Continue Reading →