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GeneMorph II Random Mutagenesis Kits - Details & Specifications
Random mutagenesis is a powerful tool for elucidating protein structure-function relationships and for modifying proteins to improve or alter their characteristics. Error prone PCR is a random mutagenesis technique for generating amino acid substitutions in proteins by introducing mutations into a gene during PCR. Mutations are deliberately introduced through the use of error prone DNA polymerases and/or reaction conditions. The mutated PCR products are then cloned into an expression vector and the resulting mutant library can be screened for changes in protein activity. Random mutagenesis allows researchers to identify beneficial mutations in the absence of structural information, or when such mutations are difficult to predict from protein structure.
The mutational bias exhibited by error prone PCR enzymes undoubtedly skews representation of random mutant libraries, diminishing the effective size of the collection produced by error prone PCR. Mutazyme II DNA polymerase is a novel error prone PCR enzyme blend, formulated to provide useful mutation rates with minimal mutational bias. Mutazyme II is a blend of two error prone DNA polymerases Mutazyme I DNA polymerase (from the original GeneMorph Random Mutagenesis Kit) and a novel Taq DNA polymerase mutant that exhibits increased misinsertion and misextension frequencies compared to wild type Taq. For the Mutazyme II polymerase formulation, the Mutazyme I polymerase and the Taq polymerase mutant have been combined to produce a less biased mutational spectrum with equivalent mutation rates at A's and T's vs. G's and C's (see Figure 1). Therefore, libraries created with Mutazyme II should exhibit greater mutant representation compared to libraries generated with other enzymes. However, the original GeneMorph I kit favors mutations at G's and C's which in some cases may be desirable.
With the GeneMorph II random mutagenesis kit, mutation rates of 1–16 mutations per kb can be achieved using a single set of buffer conditions (MgCl2, balanced dNTPs) optimized for high product yield. The desired mutation rate can be controlled simply by varying the initial amount of target DNA in the reaction or the number of amplification cycles performed.
Figure 1. Mutazyme II polymerase delivers ideal mutational spectrum Mutazyme II DNA polymerase introduces a more uniform mutational spectrum in which mutations at As and Ts occur at the same frequency as Gs and Cs. This approach produces a more comprehensive collection of mutants to discover key functional sites. On the other hand, Taq polymerase under error-prone conditions and the original Mutazyme DNA polymerase deliver bias mutational spectra and many key sites often would go undiscovered.
To address the need for efficient and flexible cloning methods, the GeneMorph II EZClone domain mutagenesis kit offers an easy and fast cloning method to perform targeted random mutagenesis on protein domains and promoter elements, while delivering a uniform mutational spectrum. Utilizing a unique cloning method, the GeneMorph II EZClone kit allows you to target specific protein domains or promoter elements without the need for restriction sites or sub-cloning (see Figure 2). The kit contains Mutazyme II DNA polymerase, which deliberately introduces mutations during PCR with a more uniform mutational spectrum compared to other error-prone PCR enzymes.
Additionally, this kit includes an optimized reaction buffer for the error-prone PCR step so that you need only vary the input DNA amount added to the reaction to produce the desired mutational frequency. The resulting purified mutated PCR products serve as megaprimers for the EZClone reaction during which they are denatured and annealed to the original donor plasmid and extended with a specialized enzyme mix containing a high fidelity DNA polymerase. Using a high-fidelity polymerase minimizes unwanted secondary mutations during the cloning process, which can affect downstream results.
The EZClone reaction is temperature cycled several times before being treated with a unique enzyme to remove parental DNA prior to transformation into competent E. coli. Our XL10-Gold ultracompetent cells are included to maximize library size and diversity. Screening libraries created by random mutagenesis allows researchers to identify beneficial mutations in the absence of structural information, or when such mutations are difficult to predict from protein structure.
Figure 2. GeneMorph II EZClone Mutagenesis Method
For Research Use Only. Not for use in diagnostic procedures


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Nausea affects most people at some time in their life, and it can become a problem for runners, especially during longer distance events such as the ultramarathon.
- Nausea is a difficult to describe feeling, usually being sensed from the stomach and sometimes nausea precedes vomiting. However there is good evidence that nausea and vomiting are separate. For instance, some people receiving chemotherapy and over a quarter of pregnant women experience nausea but no vomiting. Conversely, astronauts can experience vomiting with no sensation of nausea.
- Much of the research on nausea and vomiting is actually focused on vomiting alone, limiting our understanding of nausea itself.
- It is not possible to detect or to test for nausea. There are various physiological symptoms which may indicate that the subject is the feeling nauseous, but none of these are definitive.
- Nausea is generally accepted to be a protective mechanism. When we ingest toxins nausea frequently follows. The sensation of nausea gives a stronger conditioning to avoid whatever food was consumed just prior to the onset of the nausea. This can cause problems for people undergoing chemotherapy, as they frequently develop many food and aversions.
- Nausea tends to slow the digestive system, probably to reduce the rate of absorption of the toxins.
- After a fast, even as short as an overnight fast, people will sometimes report a mixture of hunger and nausea. Under exceptional circumstances, nausea can be confused with hunger. This may be an adaptive survival mechanism to prevent a ravenous individual from eating indiscriminately of spoiled food and becoming poisoned.
1 Causes of nausea
There are a number of major categories of causal factors.
- Infection. One of the most common causes of nausea is gastrointestinal disease.
- Diabetes. While studies are a little equivocal, there is some evidence that both type I and type II diabetics report more nausea than non-diabetic subjects. The mechanism for this is unclear.
- Anxiety. People that are suffering from anxiety have an abnormally low threshold for any type of potential threat. This may cause them to also have a lower threshold for the detection of toxins, and make them more susceptible to nausea.
- Pregnancy. During the first trimester of pregnancy nausea becomes more common, and this is often referred to as "morning sickness", or Nausea and and Vomiting of Pregnancy (NVP). NVP is believed to be a hyper-sensitization of the sensors that detect toxins as a survival mechanism to protect the fetus.
- Surgery. Nausea is a common complication of surgery and anesthesia, and is termed Post-Operative Nausea and Vomiting (PONV).
- Chemotherapy. Studies indicate anywhere from 25% to 75% of patients undergoing chemotherapy suffer from nausea. Chemotherapy related nausea can be divided into three categories.
- Anticipatory nausea. This is nausea that occurs before the chemotherapy treatment. This can be triggered by a smell associated with chemotherapy, or sometimes even the sight of something associated with chemotherapy. Not surprisingly, anticipatory nausea is most common in patients that have previously had nausea from chemotherapy.
- Acute nausea. This is the nausea that occurs during treatment, or within 24 hours of the treatment.
- Delayed nausea. This is where the patient is initially free from nausea, but 18-24 hours after the treatment nausea begins.
- Motion sickness. It is believed that everyone who possesses a working inner either can be made nauseous through a suitably provocative motion. However there are wide individual variations in the level of motion needed to provoke nausea.
- Inner ear disturbances. Problems in the inner ear can lead to motion sickness that can in turn lead to nausea.
- Space travel. Microgravity tends to exacerbate motion sickness, and different space programs reported that 35-66% of astronauts suffer from Space Motion Sickness (SMS). Note that the Mercury and Gemini missions had no SMS, probably because the small capsules restricted motion.
- Heat Illness. Nausea is a symptom of heat exhaustion (Core temperature over 38°C/100.4°F).
2 Taste Aversion
There is an intrinsic aversion to certain tastes, including sour and bitter taste that tend to be associated with spoiled food or toxins. There is also a powerful learned response, called Conditioned Taste Aversion (CTA) that occurs when nausea follows the consumption of a particular food. The food the proceeds the nausea will be avoided, and may even generate anticipatory nausea. This CTA has been shown in animals from the garden slug to humans. While CTA is "conditioned", it is quite unlike the usual classical conditioning. The time period between ingestion and nausea can be much longer than is usual in classical conditioning, and a single bout of nausea is enough to develop CTA. In addition, the CTA appears to last much longer than with classical conditioning. This appears to be a deeply embedded survival mechanism, and it only works between taste and nausea. Using other senses (sight/touch) or using a different negative stimulus (pain) does not result in the rapid, long-lasting conditioning. While CTA is generally around taste, it can often extend to smell. The smell of a food involved in CTA will often trigger nausea.
3 Hydration, Nausea and Vasopressin
Vasopressin is an antidiuretic hormone, which means that it causes the kidneys to retain fluids. Dehydration causes vasopressin to be released, and so prevent fluid loss through the urine. However, there is a relationship between vasopressin and nausea.
- Studies have shown that nausea causes a rise in and vasopressin. From a survival standpoint this makes sense, as fluid losses due to vomiting can cause dehydration. This link is so strong that anti-diuresis was proposed as a measure of motion sickness in 1957. The rise in vasopressin can be seen in subjects experiencing nausea from motion sickness, chemo therapy and substances that cause nausea, such as apomorphine. Generally subjects that do not experience nausea do not have the rise in vasopressin. Note that the vasopressin release occurs without significant changes in blood pressure or blood osmolarity.
- Studies have also shown that vasopressin can cause nausea. In one study the subjects reporting nausea also had abdominal cramping and bloating. It is not clear why vasopressin would cause nausea.
This has some interesting implications for runners.
- A runner that becomes nauseous would have vasopressin released, which could lead to Hyponatremia.
- A runner that becomes dehydrated would have vasopressin released, which could lead to nausea.
- It is conceivable that in mild dehydration could lead to an initial vasopressin release, which in turn leads to nausea, which could lead to further vasopressin release and then to Hyponatremia.

subset: commoncrawl


text: I heard a bang-bang-bang a couple of days ago and as I live on the second floor, it took me by surprise. I went to the kitchen, and saw this little thing "beaking" on the door. So I had to take a photo of him. This was through the door. If I had tried to open the door, he would have flown away or the cat would have launched himself at it.


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Sunday, November 14, 2010
So Fun Fabrics Offer!
All you need to do is leave a comment on this post to go into the draw. A winner will be drawn on Thursday 18th November.
Tisha from So Fun Fabric: 'The code for your readers is "FQ10" and it's good for 10% off their order, excluding sale and clearance items, from 11/15-11/18. They can "redeem" it a couple different ways. If they purchase existing listings, they can enter FQ10 in the Notes to Seller section and receive a refund. Or if they would like us to set up a custom listing with accurate charges, they just need to include the code in their request email to us.'
So, what are you waiting for! Get yourselves over to So Fun Fabrics and take advantage of the savings!
Posted by One Flew Over at 9:00 AM
228 comments:
- DanielleNovember 14, 2010 at 9:07 AM
Another giveaway and a discount - yeah!ReplyDelete
What lovely fabrics.ReplyDelete
Thanks so much!ReplyDelete
Looks like a great fabric site! :)ReplyDelete
Love that awesome fabric!! Thanks for the chance.ReplyDelete
Love it! I hope I win :)ReplyDelete
Awesome giveaway and discount and I love your fabrics too! Thanks for the chance to win!ReplyDelete
How generous, thank you So Fun Fabrics and Fat Quarterly!ReplyDelete
Woooo Hoooo!!!!ReplyDelete
Thanks for a great giveaway!!!!
Thanks for the chance to win the voucher!ReplyDelete
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Awesome giveaway, and thanks for the discount, gotta love it!ReplyDelete
Adorable fabric. I already know what to do with it. HOping I am lucky!ReplyDelete
thanks for the giveaway. and the discount.ReplyDelete
A giveaway and a discount! Wonderful. Happy quilting.ReplyDelete
cool! nice fabrics!ReplyDelete
YAY! love when you can get a discount! Thanks for the giveawayReplyDelete
Wow-that sounds "so fun"!ReplyDelete
- AnonymousNovember 14, 2010 at 10:01 AM
thank you for the chance to win!ReplyDelete
Wow, thank you to So Fun Fabrics! I hope I get lucky :)ReplyDelete
What a great present (for me!!!)ReplyDelete
Those fabrics do look like they are So Fun. Thanks for the giveaway. Kathie L in AllentownReplyDelete
Such lovely and enticing fabrics - thanks for the chance to winReplyDelete
Thank you for the giveaway and the discount!ReplyDelete
This is a nice giveaway. Thank you So Fun Fabrics and Fat Quarterly.ReplyDelete
Thanks for offering this give-away of such lovely fabrics.ReplyDelete
yay giveaway :)ReplyDelete
thanks for the giveaway!!ReplyDelete
- AnonymousNovember 14, 2010 at 10:33 AM
Pick me!ReplyDelete
I'm throwing in my hat. Good luck to all!ReplyDelete
So very nice! Thanks for the chance!ReplyDelete
This is just brilliant! Thanks to So Fun Fabrics and FQ!!!ReplyDelete
Such pretty fabrics!ReplyDelete
Thanks for the discount and giveaway!ReplyDelete
thanks for the discount code and the giveaway!ReplyDelete
Such cute fabrics! Thanks for the discount and a chance to win!ReplyDelete
Sandy A
who can say no to free fabric?! Thanks Sew Fun!ReplyDelete
Thanks for the chance to win.ReplyDelete
How fun, Sew Fun! Thanks for the giveaway :)ReplyDelete
Oh, I'm SO short of $$ this month already. :(ReplyDelete
But when I win, I'll feel a lot better. *S*
Wow! Love the name - Sew Fun. Thank you!ReplyDelete
I simply love giveaways:) and such giveaways the most:)))ReplyDelete
Thank you so much for the chance to win.ReplyDelete
Absolutely beautiful fabric. Please enter me in the giveaway!ReplyDelete
I could always use more fabric (who couldn't) The hard part is choosing which out of all their great fabrics.ReplyDelete
Count me in. I would love to win those gorgeous fabrics. Thanks for all the giveaways and discounts.ReplyDelete
Thanks for the giveaway. Lovely fabrics. nanasew at gmail dot comReplyDelete
They really have fun fabric :)ReplyDelete
Thanks for the giveaway!
Gorgeous fabrics!ReplyDelete
Thank you for sponsoring this giveaway. Great fabrics!ReplyDelete
I would love a chance to win. I'm already envisioning a beautiful cathedral pillow for a family member for Christmas with some of those beautiful fabrics. :DReplyDelete
I love their selection ~ thanks for the chance!ReplyDelete
yummi prints! i'm off to their store to have a closer look at that umbrella-print :)ReplyDelete
Hi,yes I am in this wonderful giveaway.. The fabrics looks realy yummi!!ReplyDelete
awesome prints!ReplyDelete
I've purchased from this shop before -- great service & fast shipping! Thanks for the chance to enter!ReplyDelete
Love, love, love these fabric lines!ReplyDelete
Winning would be great!ReplyDelete
If I'm on a winning streak, I'll do a winning streak! Thank you for the opportunity and the discount xReplyDelete
I hadn't actually heard of So Fun Fabrics before but it looks like a great selection - I would love to win!ReplyDelete
Those fabrics are beautiful. I hope to win.ReplyDelete
Thanks so much for the opportunity to win, and the discount too :0)ReplyDelete
Awesome! Thanks!ReplyDelete
Great giveaway! Thanks!ReplyDelete
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Great giveaway! and the discount is great too...i just wish i had money right to buy fabric and such....starting in Oct through January I try to cut myself off for the holiday's and concentrate on making gifts.ReplyDelete
Would love to win! Thanks!ReplyDelete
Yes please. Count me in. The fabrics are gorgeous. Thanks.ReplyDelete
Thanks so much for the coupon code and the contest.ReplyDelete
super giveaway, cute shop, thanks!!!ReplyDelete
I simply loves fabrics and need always more.... Thanks for the give away.ReplyDelete
What a wonderful shop! So tempting :-) Daniela from FranceReplyDelete
What else would I want to receive on my birthday, NOVEMBER 18th,but the news that I had won a fat quarter giveaway! Fingers crossed!ReplyDelete
what cute fabrics!! on my way to check out the shop now! Thanks for the great giveaway!ReplyDelete
I spy some cute fabrics. THANKS!ReplyDelete
Nice! I'm off to check out their shop!!ReplyDelete
Thanks for another chance...wish me luck.ReplyDelete
Yippee! Hope it's me!ReplyDelete
What is that fabric in the first picture? It is so cute!ReplyDelete
this looks like a great store! love those fabric combos pictured! :) Thanks for an awesome giveaway!! :)ReplyDelete
Love the fabric pictured ... hope I win!ReplyDelete
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Awesome giveaway! Thank you.ReplyDelete
Gorgeous fabrics, count me in! I will have to go and visit them now :)ReplyDelete
Thanks for a chance to win!ReplyDelete
- AnonymousNovember 14, 2010 at 3:13 PM
SWEET FABRICSReplyDelete
This is great! Thanks for the giveaway :) :)ReplyDelete
Oh how fun! Thank you for the chnace. Love the pinks in the first picture!ReplyDelete
Such pretty fabrics......so tempting!ReplyDelete
Beautiful! I would love to win.ReplyDelete
so pretty!!!ReplyDelete
Awesome! And I love any post that has a picture of Modern Meadow..... thanks for the chance to win. :)ReplyDelete
Wow, they stock some gorgeous fabrics! I love a good giveaway - count me in please.ReplyDelete
I love these fabrics and would love to win some.ReplyDelete
Peggy in NJ
Love that third set! Thanks for the giveaway!ReplyDelete
Thank you for the chance to win! I already have several of their fabrics marked as favorites, so spending this would be no problem ;)ReplyDelete
Ooooh love the look of those fabrics - so fresh and fun. CiaoReplyDelete
- AnonymousNovember 14, 2010 at 4:14 PM
Fat Quarterly has the best giveaways. Lots of gorgeous fabrics!!!ReplyDelete
I could definitely demolish $20 in a heartbeat. Thanks for the chance to win!ReplyDelete
What a great giveaway! Very cute fabric pictured too!ReplyDelete
I would like to be in the drawing.ReplyDelete
Thanks for the giveaway. I would love to win the $20 gift certificate.ReplyDelete
- firstname.lastname@example.com 14, 2010 at 4:53 PM
Would love to win this giveaway! Thanks! Love Fat Quarterly!!!!ReplyDelete
LOVE sew fun fabrics! That Joel Dewberry is delicious!ReplyDelete
I'm off to take a look, those Christmas fabrics look very interesting.ReplyDelete
This would be so fun to spend!ReplyDelete
These fabrics look great!ReplyDelete
Thanks FQ and So Fun Fabrics for this awesome giveaway. Please enter me into the drawing.ReplyDelete
Great giveaway! I love fabric of course. ;)ReplyDelete
- AnonymousNovember 14, 2010 at 5:19 PM
maybe this time i"ll win...sung like Liza of courseReplyDelete
Thanks for the great giveaway! :o)ReplyDelete
What a great giveaway! Way to go!!ReplyDelete
oh, that umbrella fabric is super cute!ReplyDelete
- AnonymousNovember 14, 2010 at 6:01 PM
Oooooooo! Pretty pretty fabrics! I'll be glad to take them off your hands! :)ReplyDelete
How exciting! Yesterday was my birthday, and I will gladly, shamelessly plug that in the hopes that the random number generator gods will respond accordingly!ReplyDelete
Whee! Thanks for the chance!ReplyDelete
I am trying to be good, but that umbrella fabric is on my wish list, sigh. And you have it!ReplyDelete
I do likes me some fabric.ReplyDelete
thanks for the give away. and the chance to win those beautiful fabrics.ReplyDelete
- AnonymousNovember 14, 2010 at 6:25 PM
I need some new fabric. Thanks for the chance!ReplyDelete
Love giveaways! Now I'm going to go explore...ReplyDelete
hope I win!ReplyDelete
Ooooh I'd love $20 to spend!ReplyDelete
Oh fun! Beautiful fabrics, fun fabrics, great offer. Thanks.ReplyDelete
Thanks for the chance- would love to win these in time for holiday projects!ReplyDelete
What could be better than this? A giveaway and a discount in the same post! Thanks so much!ReplyDelete
I love this line by joel dewberry... Thanks for the giveaway and discount... a great two for 1!ReplyDelete
Such beautiful fabric! It would be wonderful to work with that during the cold, dark winter!ReplyDelete
Thank you for the chance to win some very pretty fabrics!ReplyDelete
What a nice giveaway!ReplyDelete
What fun! Thanks for offering the giveaway.ReplyDelete
hooray, pick me, pick me :)ReplyDelete
Great giveaway, thanks for the offer too!ReplyDelete
Love the fabrics featured!ReplyDelete
What lovely fabrics, thanks for the chance to win!ReplyDelete
Thanks for offering such a great giveaway.ReplyDelete
I've always hankered after those umbrella fabrics...ReplyDelete
Oooo, a fabric giveaway! Thanks for hosting it!ReplyDelete
What glorious fabric!ReplyDelete
So Fun Fabrics is a favorite shop of mine on Etsy!! Tisha is the sweetest!ReplyDelete
$20 bucks of free fabric! yeehaw. Count me in.ReplyDelete
Thanks So Fun!
Thank you, thank you for the chance to win!ReplyDelete
Let me say the obvious... this is SO FUN! Thanks!!! You guys are awesome!ReplyDelete
Three delicious fabric selections - I don't normally go for pink but the designs on these just make them 'pop' / I love the crisp sharp summer shower colour range on the next set and well the last range the icy blue and the mossy green you are torn between the end of spring or the first days of winter - all beautifulReplyDelete
oh yes please! I love the latest fabrics from America, count me in! Thanks for the chanceReplyDelete
Those fabrics are beautiful.ReplyDelete
great prices AND a giveaway! great shop!ReplyDelete
I have bought fabrics from them and they have perfect service! Lovely shop!ReplyDelete
Beautiful fabrics!!!ReplyDelete
Free fabric to start Christmas presents - yes, please!ReplyDelete
who doesn't want free fabric this close to the holidays. SIGN ME UP!!ReplyDelete
Thank you for a chance to win! I'd love to be entered.ReplyDelete
Awesome fabrics !!!!ReplyDelete
Those are great fabrics! I will have to go check out that shop!ReplyDelete
Thanks you for the lovely fabric offer!ReplyDelete
How fabulous! I would be thrilled to win! Thanks! ♥ReplyDelete
Thanks - just starting to reorganize sewing area for the long winter!ReplyDelete
I would love to win some fabric! Gorgeous!ReplyDelete
Love these fabrics!ReplyDelete
- AnonymousNovember 15, 2010 at 6:51 AM
Really cheerful fabrics!ReplyDelete
Love the fabrics and sure would like to win some!!! THANKS!ReplyDelete
Yay! I see some It's a Hoot finally too!ReplyDelete
Lovely -- thanks for the chance!ReplyDelete
Thanks for the opportunity to win this fabric!ReplyDelete
So much fabric to choose from! Thanks for the giveawayReplyDelete
Thanks for the chance to win!ReplyDelete
I would not be able to pick just one of the fabrics I love....all of the fabrics are yummmyReplyDelete
Hard not to pass up the chance at free beautiful fabric! Thanks for the giveaway!ReplyDelete
Mmmmm, double yum. Thank you!ReplyDelete
I'm determined to win something from you all! LOL. Maybe this will be the time.ReplyDelete
November 18th! That's my birthday! :DReplyDelete
Thanks for the giveaway - cute fabrics!ReplyDelete
Beautiful fabrics! Thanks for the giveaway chance!ReplyDelete
Oh my, such gorgeous fabric!!! I'd love to win a gift certificate! Off to check out the So Fun Fabric store!ReplyDelete
- beth StudleyNovember 15, 2010 at 10:33 AM
I love pink! I need to have a daughter!ReplyDelete
Love this giveaway!ReplyDelete
Thank you for the giveaway! I need some fun new fabrics!ReplyDelete
Faaaabbbrrriiiiiic ... puts me in a happy trance.ReplyDelete
What a great giveaway!ReplyDelete
Would SO love to win! Could use some fresh fabric :)ReplyDelete
I'd love to win. Great collection available.ReplyDelete
Sew Fun Fabrics is new to me! I've enjoyed looking around that Etsy. Lots of lovely things there.ReplyDelete
Wonderful giveaway! Someone is going to be a very happy winner!
How fun. I would love a chance to win!ReplyDelete
Ooh! The hardest part about winning would be deciding what to buy!ReplyDelete
Great!! Count me in please *^o^*ReplyDelete
Ooh I love the fabrics pictured and now I have another site to add to my online shopping list :)!ReplyDelete
Thank you for the great giveaway. kcarlson1152[at]hotmail.comReplyDelete
awesome. I could really use this right now. I love those umbrellas.ReplyDelete
I love the colors especially the blue. I'm thinking a nice lap quilt for the back of my couch.ReplyDelete
WOW! There is some good stuff over there!ReplyDelete
Wonderfully delicious fabrics!ReplyDelete
Loving those pinks!!!ReplyDelete
How lovely :)ReplyDelete
Woo Hoo, great giveaway!ReplyDelete
Fabric giveaways AND a discount!? Whoohoo :) Count me in!ReplyDelete


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February 11, 2014 · 0 Comments
By Mark Pavilons
The seeds have been planted. And the efforts of a Nobleton-based alternative punk rock band are bearing some pretty exotic fruit.
We Outspoken, led by Nobleton brothers Anthony and Alex Mascarin, is marking some major milestones. Their music video and single, A Million People Watching, is scheduled to hit the radio airwaves and YouTube.
The visually stunning video that accompanies the song was shot this past fall at Wasaga Beach and the band is hopeful they'll add to their legions of faithful followers that currently span the globe.
The group members are unofficial Canadian ambassadors, spreading goodwill and their brand of music to eager, thirstly listeners from Germany to South America.
The band will visit Brazil for the first time this spring, performing concerts in Rio de Janeiro, Sao Paulo and Curitiba. They'll be taking in the sights, performing and networking in this Latin market March 22 to April 1.
They're quite excited to embrace this culture and the upcoming adventure. Exploring the world and playing their music makes them "feel alive," according to Alex. They've been planning the trip for years and fortunately received a lot of help from the venues and promoters in Brazil. One of the biggest marketing tools there is Facebook, radio play and world of mouth.
They'll be playing along with local bands and they're hoping for a warm reception.
On a typical Friday night, the crowds venture to see and hear bands. "This is what they do," Alex said.
They've been given an opportunity to do something amazing, and they're plucking that low-hanging fruit at every opportunity.
They have to strike while the iron is hot, and the hunger for North American music is high.
Their songs are reflective in nature, and comment on societal issues. They're more personal, too.
The group takes a hands-on approach to everything – from booking venues and travel to marketing and burning CDs. They're still largely self-funded, putting money aside at every opportunity to take advantage of new ventures.
They're constantly building bridges and making converts to their brand of music, their message and their inspiration. The reception has been quite amazing.
While most artists struggle to make a dent in the music industry here, a band like We Outspoken is highly regarded in many European nations. One fan in Germany actually got the band's logo tattooed on his arm. High praise indeed.
The band had nothing but great experiences to share from their second European tour this past September, performing in cities like Paris, Barcelona, Zurich and Prague. They performed 13 shows in 18 days in their journey that just keeps getting bigger and better.
They enjoyed this recent tour more since they knew just what to expect and were familiar with some of the cultures. They met new faces and were reacquainted with fans from their 2012 tour. Some fans drove four hours or more to catch their show.
It was humbling, Alex noted, since they were treated very much like family by their European counterparts. They found the scenery quite beautiful, especially during some of their longer drives across borders.
We Outspoken is turning heads primarily in the 16-25 age group who appreciate groups like this for giving them something unique. We Outspoken is seen as the "real deal" of grassroots music-makers with a story to tell, something that appeals to European music lovers.
Unlike following trends and top hits here in North America, fans in Europe and South America rely on music to get them through the day. They take the messages to heart.
"Music opens doors and strikes a chord," Anthony observed. He said it was really interesting when he heard people in Europe singing their lyrics, which were downloaded on phone apps or from video games.
The European experience continues to impress the band and increases their own popularity. Alex said it's important for all of us to "leave the box we live in," share with other cultures and "appreciate life more."
When the band returns from Brazil, they'll be heading off to Montreal for the annual punk rock celebration, Pouzza Fest, featuring 200 bands over the three days (May 16-18).
You can catch them at Toronto's Hard Rock Cafe Feb. 21.
They may not be household names yet, but this made-in-King export is a commodity well worth listening to.
For more, visit www.weoutspoken.com.
You must be logged in to post a comment.


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Useful links featuring Marlin Lodge
We want you to understand more about Marlin Lodge. We're not shy to direct you to their own website as we're confident that a trip there with us will cost you the same or less than booking it any other way, even directly. So follow the links below for more information.
Marlin Lodge homepage
For more pictures please have a look at Marlin Lodge's homepage.


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The following are video excerpts from the 34th Precinct Community Council meeting held Wednesday, Sept. 9, 2015, at the Columbia University Campbell Athletics Center. At the meeting, Dep. Insp. Chris Morello presented an update on crime and other police matters over the summer and responded to questions about crime and safety in the Washington Heights and Inwood communities.
Tag Archives: community policing
Meet your Neighborhood Coordinating Officers
As many of you know by now, our precinct was one of four selected to pilot the NYPD's new neighborhood policing model. Since May 18, officers in the 34th Precinct are assigned to specific neighborhood sectors every day and expected to be "active problem solvers" instead of spending entire shifts running from call to call or assigned to specific tactical units and spread out over a large area. It is a return to the "generalist" cop on a beat, supported with modern technology, better training, and additional resources to tap when warranted.
"The officers will take ownership of their sectors," says Commissioner Bill Bratton. "The public will identify sector officers as their go-to cops and not just another blue uniform."
The mayor announced expansion of neighborhood policing in June.
Each of the four sectors of the 34th Precinct has two dedicated Neighborhood Coordinating Officers (NCOs) and several "steady sector" patrol officers. The NCOs are the officers who are expected to address any police, crime or quality of life issue. Call 911 to report any crime in progress, but call your NCO for just about anything else.
This program also counts on all of us to report non-emergencies, such as noise complaints or minor crimes that occurred but are not in-progress, to 311. Each NCO has dedicated time during which they review 311 complaint records and other information to identify and address trends or emerging problems. This is a big change from before the pilot program, when officers were pretty much tied to their patrol cars and assigned to go from one call for service to another, throughout a full shift. (Much more information about the program is available on the NYC.gov website.)
The program is still in the pilot stage, so some things need to be sorted out. For example, some of the NCOs want people to call them on their (new) mobile phones, while some prefer email. We expect this will get standardized somewhat over the coming weeks. For now, look for your local police when they are on patrol, introduce yourself, and exchange contact information directly. The idea that we can call our beat cops directly is unheard of in most police departments. This is an endorsement by NYPD of the officers in the NCO roles, and it is an endorsement of our community as one that won't abuse this privilege.
Here are our NCOs:
Sector A (north of w. 179th Street to Dyckman Street, east of Broadway to the Harlem River)
Officer Edwin Rodriguez firstname.lastname@example.com
Det. Thomas Troppmann email@example.com
Sector B (north of w. 179th Street to Riverside Drive, west of Broadway to the Hudson River)
Officer Bryan Polster email@example.com
Officer Keisha Lawhorne
Sector C (east side of Broadway from Fairview Ave. to Sherman Ave., north until w. 207th Street and east to the Harlem River)
Sector D (Broadway and Sherman Ave., north to the Bronx, and everything north of 207th St.)
Officer Francisco Guzman firstname.lastname@example.com
Officer Elvis Delacruz firstname.lastname@example.com
Supervisor of the NCOS:
Learn more about the neighborhood policing plan and its rollout citywide on the NYPD website.
Read the plan in its entirety [here]
Read more about the NYPD's "Five T's" [here].


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Yuqi, whose native language is Chinese, is now a busy senior in high school. He has been living in America four years and writing for InterestEng. for two years. Recently, Yuqi has taken on writing about videos. Here's his latest commentary.
THIS video is from a Chinese show called Talent. Basically, people come and show their special talents or skills, like these two performers. But these two musicians are using vegetables as musical instruments to create amazing sounds! It's pretty funny when the host who's behind the stage says that the music can be found in the ground.
The show has three judges, and their job is to evaluate the performers and say whether they pass or not. Performers who pass can go on to compete with others. But, unfortunately, these two men did not pass. At the end of the video, one of the judges comes to the stage. He thinks they were cheating and not really playing the vegetables. But then one of the performers plays each "instrument" smoothly and shows that the talent was coming from him. Although they did not pass, they earned a round of applause. I personally think the musicians were awesome! —Yuqi


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Group of Structural Mechanics Materials Modeling, Aragón Institute of Engineering Research (I3A), University of Zaragoza, Spain
Group of Structural Mechanics Materials Modeling, Aragón Institute of Engineering Research (I3A), University of Zaragoza, firstname.lastname@example.com
One of the essential causes of disk disorders is the pathologic change in the ligamentous attachments of the disk-condyle complex. In this paper, the response of the soft components of a human temporomandibular joint during mouth opening in healthy and two pathologic situations was studied. A three-dimensional finite element model of this joint comprising the bone components, the articular disk, and the temporomandibular ligaments was developed from a set of medical images. A fiber reinforced porohyperelastic model was used to simulate the behavior of the articular disk, taking into account the orientation of the fibers in each zone of this cartilage component. The condylar movements during jaw opening were introduced as the loading condition in the analysis. In the healthy joint, it was obtained that the highest stresses were located at the lateral part of the intermediate zone of the disk. In this case, the collateral ligaments were subject to high loads, since they are responsible of the attachment of the disk to the condyle during the movement of the mandible. Additionally, two pathologic situations were simulated: damage of the retrodiscal tissue and disruption of the lateral discal ligament. In both cases, the highest stresses moved to the posterior part of the disk since it was displaced in the anterior-medial direction. In conclusion, in the healthy joint, the highest stresses were located in the lateral zone of the disk where perforations are found most often in the clinical experience. On the other hand, the results obtained in the damaged joints suggested that the disruption of the disk attachments may cause an anterior displacement of the disk and instability of the joint.
Displacement of the right condyle on the plane of movement (X and Y) and its rotation (Θ). In continuous lines, the input displacement introduced in the FE simulation; in dotted lines, the results obtained by Chen (34)
Finite element model of the TMJ
Schematic diagram of fibers distribution in the articular disk and finite element model of the disk
Diagram of the mandible where the plane of movement is defined. The displacement is imposed on the condyle at P.
Details of the two pathologic situations under study: on the left, disruption of the retrodiscal tissue; on the right, disruption of the lateral attachment of the disk to the condyle
Evolution of the opening movement of the jaw: Closed position (left), 10.5mm opening (middle), 17.5mm opening (right)
Evolution of the maximum principal (SMAX), minimum principal (SMIN) stresses, and pore pressure (PRESS) in the disk during the opening movement. Top and bottom surfaces of the disk are shown, with the following labels: A, anterior; P, Posterior; L, Lateral; and M, Medial.
Evolution of maximal principal stresses (SMAX) in the temporomandibular ligament and in the collateral ligaments during opening. These elements are shown in lateral and medial views.
Comparison of the maximal principal (SMAX) and minimal principal (SMIN) stresses in the disk between a healthy joint and one where the retrodiscal tissue has been removed (damaged)
Comparison of the maximal principal (SMAX) and minimal principal (SMIN) stresses in the disk between the healthy joint and one where the lateral attachment of the disk has been removed (damaged)
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Hello friends! Hope you're having a great day! I'd like to share my March version of Tim Holtz's 12 Tags of 2016 (even though March is over). Tim Holtz has a great tutorial on his blog with step-by-step instructions on how to create this fun technique here. I'm really loving the awesome remix of his techniques, mixing old with new! Here's my take on it!
Even though I'm late on this one, I don't really mind. I'm doing ALL 12 tags this year and I'm super excited! Every month I feel like Tim gives us a mini class, with step by step instructions on TECHNIQUES! I love them! Thank you Tim :)
I've been having so much fun with the Distress Crayons, they're awesome!
I hope you enjoyed todays project! You can find the supplies I've used via the links below. If you have any questions please let me know I love your comments, I truly appreciate each and everyone of them! As always thanks for stopping by and I'll see you next time! xx


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So here it is.
The night before I start my first day back at work since 11th March 2016 (I'm discounting the odd KIT day).
Since I joined The Motherhood.
Wow. It feels weird (but good!) to be getting into a routine of packing our bags and setting our clothes for the next day.
Something I'll probably grow to hate. Or will I? I like being organised. Hopefully it will become autopilot and my future self (the tired head-less-chicken one in the morning) will thank me for it.
A nice bath. Early to bed to read a book and set an alarm.
Argh I haven't set an alarm (bar the KIT days) since March 2016.
I'll probably not sleep tonight for fear of sleeping in.
I know, I know. I've shouted from the rooftops how I've looked forward to this day. How I've longed to get back to work for some 'me time'.
It's comical isn't it? Who would've thought I classed work as my time.
But I do.
And I am looking forward to it.
However, do you know what I'm looking forward to the most?
Coming home to this gorgeous, happy little thing I'm proud to call my daughter.
I'll look forward to having tea with her. To enjoy preparing it and then watching her eat it.
And bathing her. Watching her play with bubbles and the purple and yellow ducks. And the little spikey orange ball that lights up.
Splashing her little hands on the water and giggling every time she does it. Looking at me with those big blue eyes. Eyes that ask me to giggle back with her too.
Then wrapping her in her hooded towel where she resembles a baby Yoda.
Patting dry her utterly delightful skin.
Dressing her for bed.
Giving her a bottle of warm milk.
Reading her a story. Or two.
And then lying her in her cot. Her big girl cot which has been completely lowered now (when did that happen?)
Then tucking her in.
Actually, this is a daddy job as I don't tuck her in tight enough. She's like that magician that can escape being chained, bolted and dropped in water. Wriggles in all the right places and breaks free.
And do you know why I will look forward to all of this?
Because for nearly ten whole months, the monotony of everyday motherhood – looking after a small human by myself – takes it's toll in the evening.
I've been too tired or sick of her by this time of day to actually embrace and enjoy these moments.
Gasp. What an awful thing to say.
But it's true.
These moments tend to be flung at the other half. For him to try and embrace after his day at work.
So no doubt I'll still be tired from my day at work.
But that's just it.
I've been at work. I've had time away from her. She's had time away from me.
So those moments that we are together.
Will be unbelievably special.
I can't wait to see how excited she gets when I come home from work.
This festive period I've had the hubby on hand so I've had little breaks.
Little breaks like having a lie in.
Where I've surfaced and she's already had her breakfast and her dad has dressed her. Dressed her like only a dad can dress his daughter – in obscure outfits that should never leave the house.
I inch my way through the living room door. As sometimes she's crawling around right behind it (again – when did this happen?)
Then, she sees me.
With those innocent blue eyes.
Taking me in.
All dishevelled in my dressing gown and untamed hair. My make-up free face still puffy from sleep.
And she looks at me like
I'm the most beautiful person
in the world.
Her long little legs kick wildly. Her smile lights up her cheeky little face and the excited giggles that escape from that tiny little mouth are breathtaking.
I do have a heart underneath all of this Warrior Mode.
And my god it explodes.
My little buddy for life.
I've come a long way in nearly ten months.
It's been the toughest, hardest most emotional time of my life.
I'd go so far as to say it's been the craziest.
I'm still me. Just a different version.
One that has been on a huge learning curve.
But I look back upon my time with fondness. There have been plenty of highs and there have been plenty of lows.
There's also been some questionable parenting moments.
Like the time I couldn't remember leaving chocolate in her cot, only to discover it wasn't actually chocolate on her hand – that mammy had left the dirty nappy bag in the cot …
And as much as I've wanted this absolutely crazy time off to hurry up, I'll reflect on 2016 in years to come as the year that not only broke me – but it also made me.
I've poured my feelings and frustrations into what can be looked upon as an online maternity diary. Like diaries, there will be some entries I look back upon and downright cringe, even regret. But for most of it, I'll look back with pride.
That maternity leave not only gave me a chance to spend (albeit some frustrating and exhausting) time with this little human of mine.
It gave me the chance to take a step back from life.
To focus on something I've absolutely loved doing since I was a little girl myself.
Last week, I watched the BBC film on the Bronte sisters To Walk Invisible.
And that was empowering in itself. Three women masquerading as men to get their novels published. What a significant piece of history.
A piece I want to share with my daughter. I'd like to think that by writing this blog I'm writing some history for her too. That mammy loved writing and her dream came true to share it with the world.
On the subject of the Bronte's, I'm ashamed to admit I've never read Jane Eyre. Ouch.
I've downloaded it to my Kindle. I want to get into the routine of reading before bed again.
I digress.
This whole pregnancy and maternity experience has brought me new friends. Friends which some of whom I've not even known a year. But it's felt like I have known them a life time. Who've been there on the toughest journey of my life. And that's a strong bond.
Then there are friends I've always had who've been on this journey with me too. Through the raw parts. Who have seen me at my worst and I have seen them at their best as they support and pick me up.
Friends who bring you pizza when you've got a teething baby and all you have eaten is a bowl of trifle for tea.
Those people are priceless.
And I thank them.
For sharing this crazy ass journey with me.
That's Sisterhood for you.
That's Motherhood.
Here's to my next chapter. I'm off to make it a good one.


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The Be Well Chiropractic
Team is Here to Help You
Scoliosis Care
Scoliosis. At the end of this article will include a link to Sarah Key, physiotherapist's website. It is a lovely website that I agree with in theory and methodology.
This article will express my professional opinion as well as my personal experience. In advance, I will say I am very passionate about my opinion on this topic because I have scoliosis. I find the rods put in the spine, one of the most barbaric forms of surgery. The only need for something so severe as rods is if a child has something termed 'runaway scoliosis' and it is advancing so rapidly that no other method can change it. But beware the solution. I treat patients who have had the rod surgery and still have up to 75-degree curvatures. The spine never stopped growing crooked and now they have rods on their back. There is no evidence that the rods, in fact, did anything. Spinal growth is self-limiting and regardless of whether it grows straight or crooked, it will eventually stop growing and stabilize.
Scoliosis is idiopathic, meaning medicine has NO known cause. How many things in this day and age does medicine admit to not knowing about?! That is pretty remarkable in itself.
I have a great respect for those who research. It is a job I have no patience to do. And research is of great importance. However, double blind studies that are not financed by outside interests are rare, in all fields. I always say 'the proof is in the pudding'. If chiropractic does not work for your scoliosis, don't do it, but its worth a go. My scoliosis affected me in such a way that it lead me to become a doctor of chiropractic when modern medicine failed me. (See Dr. Janelle's, Story)
My theory of how scoliosis begins is not new: congenital factors related to genetics, nutritional deficiencies, and environment are one possibility. Another is something I see in practice: the result of a car accident, multiple head traumas from falling, or other traumatic events in babies or childhood that lead the spine to grow incorrectly. Lastly, birth trauma is an issue. When a baby is born it is often in torsion and the cranial bones and C1 especially are out of alignment. To the naked eye, you can see when a baby is not growing straight. As a provider, it is physically evident that after a baby is adjusted, they unwind.
While a theory, mine is based on the 'righting reflex'. The body will contort in any way to keep the eyes straight on the horizon. Correcting a misalignment can help the baby's body to unwind and give it a chance to grow straighter. It is amusing, these articles I read about how subluxations or misalignments aren't true. They are areas that aren't entirely functioning correctly and measured in millimeters based on spinal mechanics. This is the same as any form of medicine measured in milligrams and millimeters. What a difference psychology believes that a few milligrams of medicine make. A surgeon knows millimeters is the difference between life and death. The body is functional, fluid, and self-healing.
Regardless of the degree of your scoliosis: mild, moderate, or severe; balance is the key. A scoliosis person always feels out of balance or like they have random things wrong because of it. They do not function the same as a person with a straight spine, ***and they should not be adjusted the same. Getting adjusted typically results in an effort to balance the spine as is; I have never claimed to straighten a spine. The increase in proper posture and function results from the nerve-bone-muscle structure being released and put into correction And the surrounding supportive muscles strengthened.
When the upper cervical area in a scoliosis patient is corrected, it makes a world of difference. It feels like a spring has been unwound. While the actual curve may not change, the neurology of the body, in its own wisdom, allows the body to function better.
For people without scoliosis, it is hard to understand how painful it is to live 'off balance'.
Adjusting the patient in the convexity (curves) of the spine in a cross body fashion as opposed to bilaterally makes a significant difference in how that person functions. Likewise, I always recommend unilateral exercises for patients (lunges or one legged squats instead of regular squats for example) over bilateral. Lastly, foot mechanics can be a factor in the spine not growing correctly and the feet also need properly assessed and adjusted. Orthotics should not be cast unless the child is 'in correction' and they are not a total solution for a dynamic foot. I prefer kinesiology tape myself, as it is a functional solution.
Regardless of your age, there are many functional solutions for scoliosis. If it is evident in your child, please search and exhaust all options before you undergo rod or clip surgery. It is not a forever solution and decreases function and adds pain to your child's life.
Dr. Janelle S. Farris (who has scoliosis) is the owner of Be Well Chiropractic in Franklin TN and lives in town with her two daughters.
Link: http://www.simplebackpain.com/back-fusion-surgery.html
Marcie English
Jenn Weithman
Brittany Craft
Alysse Warburton
Chasity Hood
Denise McLain
Bonnie Hohler
Becca Stoll
"(My experience) has been amazing and I have formed a wonderful relationship with both doctors. They continue to research how to show me more exercises and treatment plans to help strengthen my body."
"My body has adjusted better as time has gone by and feels very flexible and strong doing long days at work."
Candace Gilg
"I've gotten a lot better and have learned how to take care of my own body with stretches and exercises Dr. Janelle has given me specifically for my body type."
"I would recommend not just seeing a chiropractor, but seeing Dr. Janelle. She's knowledgeable and thorough and will give you the best plan to bring you into a healthier lifestyle"
Fred Johnson
"I loaded up on Tylenol and other pain medications and tried getting frequent massages, which only provided temporary relief. I was always in pain and stiff."
"I absolutely love this office and staff. Dr. Greg gave me a great program of treatments and exercises (and) I started to feel relief after the very first session."
Michelle Smith
"Chiropractic should be in one's priority list, just as taking vitamins and eating healthy. A must try, as you may not know how much better you can feel. Depending on the issue, I strongly feel chiropractic care is important to feeling healthy and staying active."
Wendy Cripe
"I was kind of scared of the adjustments but I figured chiropractic care was the only medical care that could "fix" the problem. Dr. Hutti was very kind and good about explaining what was going on in a clear way that was easy to understand for an average person with no medical background."
"(Dr. Hutti) recommended continued adjustments to re-align the vertebrae, daily exercises to keep movement and to strengthen my muscles, to hold vertebrae in the correct position."
"I am so thankful for their knowledge and help!"
Anna Clark
Anna starting coming to Be Well Chiropractic with lung complications due to cystic fibrosis. She was having middle back pain mainly due to coughing. She has "always been a huge fan of chiropractic care when it comes to keeping (her) immune system at its strongest."
"Dr. Janelle has been a huge factor and partner in my health. When your body is aligned right it can heal itself so much easier. I think chiropractic care is crucial to my health and quality of life."
Since seeing Dr. Janelle her "breathing has become much easier and more free."
Heather Dupes
Deion Sims
"I am better now than when I first came. I continue to get/feel better with every visit. I am learning things that I believe will allow me to stay healthy for a very long time."
Donna Hartman
"I find that going to Dr. Greg was very helpful. I tried everything else (and) nothing seemed to help. My headaches are gone. I would recommend trying Dr. Greg. It does work."
Lauren Forsythe
Her first impression of chiropractic, this office, and the doctor was that "Dr. Janelle has a holistic approach that will have long-term benefits." She was "very impressed with her knowledge and her approach."
Since seeing Dr. Janelle, Lauren has gained back her range of motion in her neck and back. The numbness in her leg has gone away, the pain in her rib has lessened, and she no longer has headaches.
"I would recommend improving your lifestyle habits such as diet, physical activity, and chiropractic care."
"I feel that this is a life-changing practice and that (chiropractic) is necessary for a healthy life."
Amye Miller
Lauren Bagley
"(I) feel so much better and the pain is practically gone."


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Court orders Dinakaran to appear in connection with FERA case on Apr. 18, 19
| Updated: Aug 23, 2017 11:20 IST
Chennai (Tamil Nadu) [India], Apr. 13 (ANI): The Egmore magistrate court headed by Judge Malarmathi on Thursday ordered the All India Anna Dravida Munnetra Kazhagam (AIADMK) general secretary T.T.V. Dinakaran to appear for questions in connection with the Foreign Exchange Regulation Act (FERA) case against him on April 18 and 19. Earlier in the week, the Madras High Court refused to defer Dinakaran's trial in a money laundering-cum-foreign exchange violation case till April 12. Justice R. Mahadevan said that the court was neither staying nor deferring the trial against Dinakaran in the Economic Offences Court-II. Justice Mahadevan agreed with the Enforcement Directorate (ED) counsel's submission that in the absence of an interim stay, the lower court was free to go ahead with Dinakaran's trial on April 10. The judge denied reprieve to Dinakaran while hearing his petition against the court's order which had refused to defer his trial by six weeks. (ANI)


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By renting private meeting rooms in Birmingham AL, you'll avoid some of the high rates that many hotels tack on to reserve conference rooms. Even if fees are reasonable, you aren't always guaranteed a venue that meets your needs. You may end up with a room too small or not equipped to hold your meeting. With our meeting rooms in Birmingham, you can book cheap deals in advance online or make reservations to secure a specific meeting room. Space can be conveniently rented for short term and long term time frames. Even if your desired meeting room is booked, we can usually find a temporary solution until your desired meeting space is available for rent.
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text:
Z-Coil Videos
Pain - How Z-Coil Can Help
Styles for Men
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Custom Fitting
Contact Us
Z-CoiL® Pain Relief Footwear™ Custom Fitted to You
We specialize in the custom-fitting of Z-CoiL® footwear, shoes uniquely designed to relieve foot, leg, and back pain.
Many of our customers suffer from nagging to severe pain in their feet, knees, hips, or back. Others ache from working long hours on hard floors.
At Z-CoiL® Pain Relief Footwear™ we take your pain issues personally. We will do whatever we can to maximize the pain relief benefits our footwear can provide. Our trained staff will measure your feet, assist you with your footwear selection, and make any necessary adjustments to the footwear to meet your individual needs.
Relief from pain may be only a step away.


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- Angie has received several email orders for her book. Thanks for your support! If you have read it, do leave your comments here. She'd be most happy to hear from you about your thoughts and views on her maiden publication~
- Catch Angie on the <早安你好> next Tuesday (1 Sep 09) when she'd be appearing on the programme to talk about her book. The segment has been scheduled to be screened at 0810hrs. So do tune in to Mediacorp Channel 8 at that time!
- Grab a copy of My Paper on 1 Sep 09! There'd be an aritcle published in there on "便当前面的故事". We were told the coverage is going to be quite extensive, so we're naturally very excited about this. Watch out for it!
- Diana has posted a wonderful review of the book (she calls it her 阅读报告! Ha!) up on her blog. Thanks, Diana! Read her book review here.
- Having fullfilled the first portion of her dream, Angie proceeded to fiercely pursue the second portion of that audacious dream - to personally hand-deliver this piece of work, the birth of which has been inspired in a big part by Mayday 五月天, to the members of the band themselves. We are exhilarated to announce that Angie is now all set to actually carry out this dream of hers. She'd be meeting up with Mayday tonight, right after attending their concert! More updates on this soon!
Updates @ 24 Aug 09
Those wishing to place orders (or autographed copies~) directly from the author may also do so by clicking here. To enjoy the special online discount, quote "kinigu" in your email subject.
If you have read this book and enjoyed it, help promote it by placing the hyperlink banner below in your blog!


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Information For
School for New Learning > Academics > Graduate Programs > Programs > Applied Technology (MS) > Specialization Requirements > Applied Human-Computer Interaction
This area of specialization within the MS in Applied Technology program prepares students to design, implement, and evaluate computer interfaces so that they are accessible and easy for people to use. This interdisciplinary specialization integrates concepts and methods from computer science, graphic design and the social sciences to provide a comprehensive understanding of the user-centered design process. The combination of coursework, liberal learning seminars, and independent workplace-based projects advance students' capabilities to influence organizations and apply a repertoire of strategies and techniques to the user-centered design process, including usability assessment and testing, user task and preference analysis, information architecture, and construction of dynamic and function-driven web sites and other applications.
Introductory courses may be waived for any of the following conditions:
Three courses chosen from the following:
Content displayed from Applied Human-Computer Interaction on DePaul University Catalog
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CodeTwo QR Code Desktop Reader is a simple tool which allows you to work with QR Codes on your PC.
QR Codes? They're the characteristic blocks of square dots which you'll often see on ads, websites, packaging and more. Mobile phones can interpret them with ease (once you've figured out the appropriate app to use, anyway), and QR Code Desktop Reader now brings the same ability to Windows.
The program makes it easy to grab a code from your screen, for instance. If you see one within your browser, say, switch to QR Code Desktop Reader, click "From screen", draw around the code, and the program will display whatever text it contains.
QR Code Desktop Reader can also open and read QR Codes stored in all the main graphics formats (BMP, GIF, PNG, JPG, TIFF).
And whatever text the code contains may then be copied to the clipboard, or saved to a file, with a click.
It's mildly annoying that such a very simple program (just a single executable, essentially) requires installation. Making it portable would have been more convenient.
We can't complain too much, though: QR Code Desktop Reader is free, easy to use, and a very handy addition to any desktop, and that's good enough for us.


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Michigan Democratic Party State Convention, Cobo Hall, Detroit, MI, 8 am to 5 pm
- 8 am to Noon – Registration and Constituency Caucuses
- Noon – 1 pm – Lunch Break
- 1:00 pm – 3:00 pm Congressional District Caucuses (8th District W2-63, 9th District O3-45) – Officers and State Central delegates to be elected
- 3:00 pm – 5 pm Riverview Ballroom, election of MDP Chair, two Vice Chairs, remarks from Senator Stabenow and other elected officials.
to vote you must receive your Delegate credential at registration. Non-voting members can attend this convention.
NODC February Meeting, Wed. Feb. 16, 6:30 -8:30 pm, Clansman Gaelic Pub at Canterbury Village (upstairs meeting room), 2369 Joslyn Ct., Lake Orion, MI, 48360 [Map http://mapq.st/eIG4Jn ]
- Guest Speaker: MDP Chair Mark Brewer
- Guest Speaker : Lance Enderle, candidate for MI- 8th Congressional District
- Please bring canned and packaged food for our ongoing community service project to support the Oxford/Orion Fish Food Pantry.
- NODC Membership is now due (membership is on a calendar year basis) – See membership page for information and form.


text:
In Design
Tysons/Old Meadow Road Bike/Ped ImprovementsNear I-495 and Route 123 in Fairfax County
Area Maps
Construction: Spring 2020
Est Completion Date
Fall 2020
In Design
$13 million
Northern Virginia
Abraham Lerner, P.E.
Senior Project Manager
About the Project
This project, in cooperation with Fairfax County, will build a pedestrian and bicycle bridge and shared-use path in the vicinity of Route 123 and I-495, to improve bicycle and pedestrian safety and connectivity in the Tysons area.
Improvements include a new 10-foot shared-use path from near Tysons One Place and Fashion Boulevard to Route 123 and Old Meadow Road via a new pedestrian and bicycle bridge over I-495; the path will mostly follow Old Meadow Road.
Based on the results of the preliminary engineering phase of the study, which included extensive public outreach, the "Option 2" alignment was selected for final design.
Public Involvement
A design public hearing was held in June 2018, materials presented include: Meeting Materials | Displays | Comments from June 18 Public Hearing
Two design workshops were held in Nov. 2017, materials presented include: Nov. 28 Presentation | Meeting Materials | Boards | Comments from Nov. 9 Meeting | Nov. 9 Presentation
A public information meeting was held in May 2017, materials presented include: Presentation | Brochure | Comment sheet | Displays: Context map | Evaluation scoring (Pros & cons) | Renderings of design options | Plan views
The project team has worked with the community over the last several years on preliminary design options, review a summary of outreach.
Design Public Hearing: June 2018
Environmental Studies Memo Available: August 2018
Design Approval: November 2018
Begin Right of Way Acquisition: Spring 2019
Begin Utility Relocation: Fall 2019
Begin Construction: Spring 2020
Estimated Completion: Fall 2020
Estimated Costs
Preliminary Engineering - $1.9 million
Right of Way Acquisition and Utility Relocation - $3.1 million
Construction - $8 million
Total - $13 million
This project is financed with federal, state and local funding.
Environmental Studies Memo - August 2018
Document | Public Notice
AM/PM Peak Hour Traffic Counts at Selected Intersections (Dec. 2017)
Preliminary Engineering Report (July 2017)
Concept Plans
The Colonies of McLean Meeting Presentation (March 2017)
June 2014 Public Comment Summary Report
Public Hearing Brochure and Comment Sheet (June 2014)
Aerial Overviews: 1 | 2 | 3
Typical Sections: Chain Bridge Road and Idylwood Road
Re-Evaluation Document (March 2007)
I-495 HOT Lanes Record of Decision (June 2006)
Final Environmental Impact Study (April 2006)
Project Numbers
State: I495-029-078, P101, R201, C501, B630
Federal: CM-495-5 (091), CM-495-5 (092)


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Right now there's a Simple Stories exchange thingie with Maya Road, which means we get to play with their products combined with Maya Road stuff. Here's what I created for it – an itty bitty gift (this one was fun to make! Both the gift itself and the embellished wrapping). And as usual with these product exchanges, there's chances to win stuff! :)
I thought I'd share my favorites atm – right now this crystal star pin is a HUGE favorite from Maya Road. I so need more of these! *loves*
Maya Road products: Vintage wood spools, Trinket pins (crystal star), Mixed Blossom Mini Chipboard, Small Organza Roses ribbon (Olive), Mini Ticket Strip Transparencies (White), Snowflake Clear Stamps. Simple Stories products: 25 Days of Christmas Collection Pack.
See the star pin once again? Yepyep!
Another product favorite: Crackled accents (the ones I'm using are from Ranger), as used on the butterfly here! Both the bottle/tube one called crackle accents and the distress crackle paint – rock candy (the other crackle paint types are utterly cool aswell).
Truly adore these cute mini wooden spools :)
Maya Road products: Kraft Envelopes - Decorative, Butterfly Chipboard, Trinket Beads, Trinket Pin (Crystal Star), Wood Mini Spools, Cherry Red Glitter. Simple Stories products: 25 Days of Christmas Collection Pack.
If you would like more Christmassy inspo, Prima has a whole post dedicated to Christmas cards atm. Here's my contribution to that one =)
Once again distress paint was used – this time on these roses. Not sure if it shows too well on the photo (note to self: need macro lens!), but – it's pretty cool irl :)
Product List:
- #843281- North Country- Forest Notes
- #843267- North Country- In The Forest
- #551339- Say It In Crystals
- #553289- Coventry Rose- North Country
- #550448- Toggle- Quirky
- Ranger Ink: Distress Crackle Paint-Rock Candy, Distress Ink- Vintage Photo
Another favorite, or perhaps I should say a must, is the Raisen's from Glue Arts. I use it on seriously pretty much everything, burning through my stack atm :/ It's like pop up glue dots, invisible and of perfect thickness to give a subtle dimension…and so far it's been pretty darn sticky aswell :)
Disclaimer: yes yes, I'm on the dt of a few but not all of the products' manufacturers mentioned as my faves. Still allowed to share which products of theirs which's my fave atm, no? :)


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I looooove retro hairstyles. I wish I could walk around every single day looking like Ava Gardner or Rita Hayworth. Unfortunately I'm not very skilled when it comes to hair. But before going out on Friday night I had a go at some kind of victory rolls, using pin curls as a way of prepping my hair for the do.
Step 1. pin curls in damp hair with some setting fluid.
Step 2. loosening the cursl with fingers.
Step 3. shaping hair into rolls and fastening with hair pins.
This is the result, not half bad if I may say so myself! And I may.
If buying glasses wasn't so horrendously expensive I would get myself a pair of retro ones to match this look. My hipster-wannabe-aviator specs are looking just a bit out of place here.


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Crazy Uncle Ned has collected many underwater items, but they must be sorted! Test your memory in this oceanic version of Concentration!
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I just found out that Khalil Gibran's inspiring book, The Prophet was turned into an animated movie starring Liam Neeson and Salma Hayek. This is one of the best books I've ever had the honour of reading. I have a deep love for it, so hearing that it's been turned into an animation makes me a little nervous. Hopefully, I'll be able to find a copy … and that it will be well done.
If you enjoyed this post, I encourage you to Share it:


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|Beyond The Yellow Brick Road
|Written by themindencourier
|Wednesday, 07 July 2010 21:00
Although Brette Covington has served as administrative assistant at the Minden Opera House since last November, many area people know her because of her role as Dorothy in the recent Minden Community Players production of The Wizard of Oz. Brette has resigned from her job at the opera house and is about to embark on a new career path.
For complete story subscribe to The Courier


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The 12th Annual URS
April 27, 2019
8:00 AM to 5:00 PM
CHSS Building
Faculty moderators support the URS by offering professional feedback to student presenters in order to facilitate their academic growth.
Click Here to Register as a Faculty Moderator
Registration for faculty moderators closes on March 31, 2019
Moderator Information
Moderator Form Information
- Sample Moderator Form
- Forms should be given to presenters after their sessions are over
- Critiques of student presentations should be listed out on the evaluation form only and not relayed during the question and answer sessions
* If you are unable to give the student his/her form, please give them to your Honors Student Ambassador Moderator or turn it in at the registration desk.
Moderating Oral-Media Sessions
- Each session will include 3-4 presenters who will each be allotted 12-15 minutes to present his or her research
- Moderators will be responsible for filling out one evaluation form per presenter
- A question-and-answer period will be held after all students have presented
* Honors Student Ambassadors will preside over sessions introducing presenters and keeping track of time.
Moderating Poster Sessions
- All posters are presented concurrently in the LSC Ballroom
- Moderators will be responsible for filling out one evaluation form per poster they are assigned
- Student presenters will be standing near their posters throughout the session to answer any questions regarding their presentation
The Elliott T. Bowers Honors College
Academic Building IV Suite 201 | Box 2479 | Huntsville, Texas 77341-2479
Phone: (936) 294.1477 | Email: email@example.com


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Forward thinking NZ food company Hubbards has just launched two clever, new breakfast cereals.
Part of the new Clever Clusters range, Innocent Indulgence and Metro Modern have been carefully crafted to deliver the "dream team" of flavours – a taste explosion that will have consumers hungry for more.
Innocent Indulgence is a fusion of real dark chocolate teamed up with delicious raspberries to create a luxurious "not so naughty" treat. With 70 % wholegrain clusters the cereal is high in fibre and has reduced fat. It is the first time real chocolate has been used in a cluster. Now you can indulge yourself without the guilt. This cereal will be loved particularly by people who enjoy a treat. But make sure it stays on the top shelf, otherwise the whole family will be helping themselves to it!
Drawing on the taste and nutritional value of ancient grains, Metro Modern has been developed for modern tastes. The medley of grains including quinoa and buckwheat along with cinnamon flavours and seeds combine in what will become a sure fire flavour favourite. The light cereal includes healthy linseed, sunflower and almond seeds (LSA) to keep you healthy on the inside, clusters that are reduced in fat (30 per cent less fat than Hubbards Simply Berry Clusters), and the cereal contains no wheat or gluten, which is perfect for people on a restricted diet or simply choosing a healthier lifestyle. This cereal is for the discerning consumer, one who is looking for something different and a guaranteed jump start to the day.


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With winter's cold, grey days still lingering, now is the perfect time to take a break and enjoy a little sun. Secret's Footcover collection features fashionable, comfortable options for enjoying a tropical destination in style.
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A little lace
Shop for souvenirs while sporting a pair of these Low Cut Padded Lace Footcovers. Ideal for pairing with flats and ballet slippers, they feature pretty lace detailing and padding for cushioning the ball of the foot. Available in black, retail price $6.99 (two pairs.)
Foot rub
From Mayan ruins to designer outlet malls, Secret's Unique Massaging Sole Footcover keeps feet happy for the duration of the adventure thanks to a textured sole. Available in medium nude and black, retail price $6.49 (two pairs.)
Starry, starry night
And when it comes to enjoying those sultry evenings, Secret has a variety of Foot Tubes and Toe Covers ($4.99, two pairs) that are ideal for everything from sling backs to open-toe sandals!
The entire Footcover collection is available exclusively at major retailers nation-wide.
Recommend to a friend


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Friday, September 9, 2011
wild grapes, zucchini seeds, Chinese mantis
They are significantly smaller, tend to ripen at varying stages.. and are sour. Like with many wild fruits, the seeds are significantly larger with less flesh. These are lovely when mixed with other fruit in juices and jams. While munching on them off the vine is fun, the seeds can be daunting, rather like when bits of popcorn get stuck in the back of your throat. The chickens were snaking on them as well, often jumping up like Michael Jordan with incredible "air time" to snag a few treats.
There are several species native to North America. With wild genetics, each one is a bit different than it's neighbor. Even if you are not pleased with the grapes these natives provide, the vines do offer more. Grafting is an option. Many are not aware that wild strains of grapes from North America saved many vineyards in Europe. Our wild types are resistant to a disease that was ravaging European cultivars.
If you are interested in grafting, this is a helpful link.
I was surprised by this massive guardian of the garden.
See her? A Chinese mantid. 4 inches my foot.. she's over 6 from her head to the end of her body.
A beneficial invasive, imported for bug control over 100 years ago. We have a couple of these wandering about. You can see the Japanese beetle damage to the vines. Minimal damage compared to the vines that were not patrolled by my feathered friends.
I've pulled my first zucchini for seed saving this year. You have to let the fruit get fully ripe.. which a ripe zucchini has a hard shell and is yellow.
This is Ronde de Nice, a small round French heirloom strain. These are great for stuffing. I like a few of these.. and let them hang out until close to Halloween. The seeds benefit from some storage time of the fruit. I'll carve a few out, save the seeds ( and roast the extras).. to be small jack-o-lanterns.
These are cucurbita pepo.. and many "summer" squash are as well. That means they will cross with many other garden favorites. I controlled cross pollination by picking the male flowers of the other c. pepo that were soon to bloom. They became dinner.
Same drying method as others. Clean off the seeds, dry them well (will snap in half when bent). They can last a decade and better in proper storage and still maintain decent viability.
Ok.. have to run! Best to you all!
5 comments:
I have been seeing the mantis ladies everywhere this Summer. I spied three very pregnant ones down by the outter apiary the other day. I always wonder if some poor mantis fellow lost his head when I see them .... OUCH!!!ReplyDelete
I got buzzed by one.. it was by the front door and it was night time. Rather unsettling! The chickens haven't found any yet.. but they have devoured quite a few small frogs.ReplyDelete
I saw a healthy number of mantids this summer too, but none so big as your 6" lady!ReplyDelete
That zucchini looks like a pumpkin! We grow the Black Eel variety. Have been for at least 5 yrs now, I keep the seeds every few years. Taking off all the male flowers is smart! Then you don't have to get up so early to make sure the bees/bugs haven't had their fun yet before you hand pollinate, then tie/close the female flower up. I've been pretty successful keeping varieties pure by adjusting planting times. Like starting a variety of lettuce a few weeks before starting another, so the flowering time is not concurrent.
I have yet to stumble across wild grapes in my area...one of these days. I enjoyed hearing your thoughts on the "wild" apples in your previous post too...we just processed a bunch into apple sauce.ReplyDelete
@ AJK.. pulling the male flowers was just what I had gotten used to because in CO the squash bees would eat right through taped blossoms. Organza bags also work (yay.. finally bridesmaid dresses can be used a second time).. and I've gone so far as planting certain ones in containers, taking it inside overnight so I could control the blooms the next day. The container thing was short lived.. lol.. bad idea when you have a bad back. Pulling the male flowers was easiest, and stuffed blossoms dipped in tempura batter and fried are yummy.ReplyDelete
@ Mr. H.. I hope you find some! These bitty apples will be the end of me! lol my thumb looks like a papercut torture demonstration.


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9 Videos - The Ian Norbury Collection
An incredible set of teaching videos which help the carver to master a range of techniques. These films are each around an hour long and are supplied with printable plans. If you wish to read more about each video please visit the following page.
Ian Norbury Downloadable Videos.
Download Now - $59.99 (Save 29.92)


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Immerse between private gardens and pinewood, is the ideal place where you can spend all the happiest moments.
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Sunday, August 30, 2009
Clay Pavers
4 comments:
I love them, they match well together... How is it all going for you?ReplyDelete
Thanks Fee, we love them too & the price is a real bargain!ReplyDelete
Our plans should come out of council this week so not long now till we start YAY.
We had our kitchen appointment on Saturday with Cobbitty Grove Kitchens.It went well & we are getting a quote on a few extra's but will depend on how much extra $$ it costs!
We decided to go for gloss poly... i was a bit worried about finger marks showing but it looks so good & I noticed that you are having it so It must be a good choice!!
Will let you know when we get a start
Congratulations on your approval. You must be getting so excited... the butterflies start in your tummy yet?ReplyDelete
Yeah, we got white gloss poly. When we had our appointment, I was leaning more towards the satin look, but both Mark and Anita said that the gloss looks so much swisher ;D. So we got the gloss. I am glad that we got it now. I think that you would get fingerprints on both though, no kiddies touching the cupboards, or the walls, or the ... haha!!! Do you have any kids?
Thanks Fee,Yep getting excited now even though we have built a few times before it still feels like the first time!ReplyDelete
Yeah we saw samples of the different finishes & you could see fingerprints on all of them. I'm a bit older than you (45)so my 2 boys are all grown up now...well older don't know about grown up ha ha...22 & 24 years.The 22 yr old still lives at home & I have told him he has to only touch the handles & he just rolled his eyes...boys!! So I have been through all that kiddies touching everthing stage but I tell you it never really stops when they get older!!
Now I work with them in childcare aahhh.
BTW I noticed that you are a hairdresser...do you work in the camden area as I will be looking for a new one when we move out there... we are renting at Illawong atm.


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Secret Garden is an award-winning Irish-Norwegian duo playing new instrumental music, also sometimes erroneously known as neo-classical music. Secret Garden features the Irish violinist Fionnuala Sherry and the Norwegian composer-pianist Rolf Løvland. The duo has sold over 3 million albums and won the Eurovision Song Contest for Norway's second time in 1995, with the composition "Nocturne". It was the only
In movie industry terminology usage, a sound track is an audio recording created or used in film production or post-production. Initially the dialogue, sound effects, and music in a film each has its own separate track (dialogue track, sound effects track, and music track), and these are mixed together to make what is called the composite track, which is heard


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