text:
This is the first time Perdomo's beard has played this high up on the East Coast since he made his major league debut against the New York Mets! (4/15/09). And thought he temptation to celebrate is great, clearly Perdomo's beard won't rest until it attains that lofty perch of being the most feared set of facial follicles in the major leagues.
So he will toil along side other players with former big league experience. No longer will he be the sage old timer in the bullpen, impressing the young whelps with stories of his time in the show (where you hit white balls for batting practice and the women all have long legs and brains) now he'll be part of a staff where the vast majority have played in the bigs (many, recently).
|Courtesy Lewis Carroll
and courierpress.com
But let's not spoil this with cynicism or "facts", the truth is that Luis Perdomo's beard is one step closer to making it back to the major leagues. After battling, fighting and holding fast to that fervent dream of a return to glory, he's moved closer this week. And no matter how long the odds or how questionable the circumstances are, it's great to see a great bit of facial hair (and a dedicated player) keep living their dream.


text:
Thursday, November 6, 2014
10 comments:
Whatever you call em, I love the movement and texture on those little jumprings! You need to coin some kind of special name for that :)ReplyDelete
These are yummy colors, shape, and texture! Love them!ReplyDelete
Beautiful and moody! I love the finishes and colors you've combined here, the stacked rings are a great touch. Love Petra!ReplyDelete
These are gorgeous Claire! Love the color combo...so natural.ReplyDelete
Beautiful Claire! And freebies to boot! love the golden bronze colors together. These have a rustic and yet really elegant look at the same time. Love it!ReplyDelete
Very cool, love the stacked textured jumprings!! And the colors are fantastic!ReplyDelete
Ohhh so very very pretty! I absolutely love the style and the colors. Love, love, love!ReplyDelete
I love that little jump ring embellishment, and the colors are fabulous.ReplyDelete
I have heard them called love knots, but somehow that sounds a little rude. Maybe that's just me....they are lovely earrings - Petra's spikes always do the trick!ReplyDelete
These are amazing...perfect for autumn and on into winter. I would wear them daily!ReplyDelete

subset: commoncrawl


text:
Hi everyone! Are you feeling a little tired of the same-old political discussions? Wishing there could be more math involved? If so, I've got a blog series for you!
In light of the upcoming elections, I thought it'd be a good time to write on The Math of Elections. In this post I will talk about the Gibbard-Satterthwaite theorem. Tomorrow I will write about how this theorem illuminates the problems that exist in our primary system. Following that I will talk about Kings, suggest alternatives to our primary system, discuss the electoral college, analyze whether voting matters, and lastly, on election day, will analyze the complexity of vote counting. Let's get started.
The Gibbard-Satterthwaite theorem deals with elections where there are at least 3 candidates running for a single position. Observe that most elections have these characteristics — for instance most US elections begin with primaries that feature at least three candidates. Most elections that take place within your community or among your friends would also qualify. And even in our largest nation-wide general elections, many races feature an independent or third party candidate who will receive a notable number of votes.
Let's assume that every member of the electorate explicitly ranks their preferences. They may prefer the Democrat's candidate most, then the Libertarian, then Herman Cain, then the Republican, then the Green Partier, etc.. From this, we are going to generate society's preference list in some way, with the most preferred candidate being declared the winner. The goal, of course, would be to find a way to do so that is fair. One procedure could be to ignore how people voted and simply place the candidate's names in alphabetical order, and declare that to be society's preference ranking. But, of course, that is not fair.
What about a system like our own? Our current primary system, for example, takes each voter's preference list, ignores everything but their top choice, and gives one vote to the candidate who was that top choice. Then the candidate with the most votes wins.
Is this system fair? How can we tell? And if it isn't, does a fair system even exist?
Well, unfortunately for society, the Gibbard-Satterthwaite theorem roughly says that no voting system with 3 or more candidates, decided by these voter preference lists, is fair. First let's talk about what makes a voting system "fair"? I believe that most everyone would agree that the following properties are ones that a fair voting system should have.
Dictatorial Property. For starters, a dictatorship does not seem fair. So let's say that the first condition that we demand is that there is no dictator; i.e. the result of the election cannot simply mimic the preference of a single voter.
In Iran, for instance, it appears that many citizens voted for president, but the only vote that mattered was Ahmadinejad's vote for himself.
Winnability Property. Second, it must be possible for any candidate to win. A system where the winner is decided by picking the person whose name comes first in alphabetical order does not seem fair. We gotta give Zygarri Zzyzzmjac a fighting chance!
Manipulability Property. Finally, it should not be to one's advantage to engage in tactical voting. Meaning, it should never be possible for someone to submit false preferences because doing so will help their true preference win.
So, for example, suppose that at the moment the Societal Ranking Procedure (whatever it may be) reports that society likes the Republican candidate the most, then the Democrat, then the Green Partier, then Herman Cain, then the Libertarian. If I personally have the ranking of Republican then Democrat then Herman Cain then Green then Libertarian, but I decide to interchange Democrat and Libertarian or Libertarian and Herman Cain, then that should not change the fact that society prefers the Republican to the Democrat. It would make no sense if suddenly the Democrats candidate jumped into first place. More to the point: no one changed their preferences with respect to the Democrats and the Republicans, so it does not make sense that society should have changed its preference either.
So those are three conditions which all seem fairly reasonable ones to ask of a voting system. However, Gibbard and Satterthwaite showed that these three conditions can not all happen simultaneously. Given any voting system with at least 3 candidates, where the winner is deterministically chosen as a function of these voter preference lists, either your system has a dictator, or some candidate is incapable of winning, or there is a way to manipulate the system by being dishonest. How sad.
I will omit the proof of this theorem in order to keep this series accessible to a large audience. Possibly some day I will come back and write a post proving it. But that day is not today.
This series will continue tomorrow when I will talk more about this theorem in the context of one unfair electoral system: the US primaries.


text:
Event Date:
Event Location:
- Webb 1100
Title: Observational evidence for a geodynamo driven by thermal energy in the outermost core and by precession deeper in the outer core
Abstract: VGP (Virtual Geomagnetic Pole) paths during reversals are preferentially located in roughly north south circum-Pacific arcs, above where the lower mantle is coolest. This indicates that the movement of magnetic flux concentrations in the outermost core responds to thermal constraints during the reversal. Hence thermal energy is involved in driving the geodynamo. The preponderance of the occurrence of reversals when the obliquity is lower than the average within the last 5 Ma, and their preferential onset during the decreasing half of the obliquity cycle provide evidence for a role of precession in driving the dynamo. The geodynamo therefore appears to be driven by a combination of thermal and precession energy. A reversal with its decay of the dipole intensity by almost an order of magnitude, the polarity switch, and regrowth of the new axial dipole involves an intermediate equatorial field source, whose polarity also switches with the axial dipole and the whole reversal process takes roughly one obliquity cycle of 41,000 years.


text:
Day 28 of 6000 steps or more!
Day 28 of 6000 steps or more!
That's fantastic, nswef!
I've completed 46 days of writing.
Go us!
EJ that's great! This has helped me stay focused. Day 31, but what excites me is that I've had 6 days this month of at least 10 minutes steady walking-the pedometer calls it aerobic as long as it is 10 min. in a row. The aerobic ranged from 847-3648 steps.
That's fantastic, nswef! This is helping me stay focused too.
I've completed 48 days of writing.
48 days is a LOT of writing. Bravo to you. I am on 32 of 6000 steps and made myself do the extra 300 last evening to push it over to 6000. Not hard, but often will skip it. Plus I see on the other thread you are having to change to electronic grading. Ummm- such fun to have new technology!
Day 13 of decluttering- took 15 minutes before I had to leave for book club and got rid of 4 grocery bags of fabric, books and clothes that were on a cupboard shelf!
There are currently 1 users browsing this thread. (0 members and 1 guests)


text:
Tag Archive: Snow
Cleopatra's Needle (in Central Park)
Cleopatra's Needle (Wiki) isn't really associated with Cleopatra, and predates her quite a bit (1450BC), and Wiki has the full story about how it got to New York in 1880… it may very well be the oldest human-crafted object out in the public in NYC.
Belvedere Castle (Central Park)
The view from the castle, which is an odd piece of architecture in my opinion to begin with, is really nice, especially the view of the Delacorte Theater and the Turtle Pond, which didn't seem to have any ducks on ice at the moment.
The Rock
I shot this panorama the same night as I shot "Hearnshead." It was really cold, and Peter was already a bit complaining about the cold. We found one of the many strange rock formations that are very common in Central Park. Looking at this Panorrama, i think i could have choosen a slightly different location, …
The Cop Cot (Central Park South)
Nights in Manhattan full of those beautyfully wasted photons. Just get out and capture some of them. Digital, about 25700x8000px.


text:
The Leahy-Smith America Invents Act (AIA), H.R. 1249, was passed by the U.S. House of Representatives on June 23, 2011, and by the U.S. Senate on September 8, 2011. The bill now goes to President Obama to be signed into law. http://www.uspto.gov/patents/init_events/aia_implementation.jsp
One of the most important provisions of this Act is that it introduces a "first-to-file" system as opposed to the "first-to-invent" system that is currently in place. This will bring the US system into line with the "first-to-file" system used in Australia. While it has its detractors, I welcome this change because, to some extent, it saves my clients having to adopt a different set of rules for the US. In the complex world of patent practice, any such alignment is to be welcomed.
Here's the wiki on the difference between the two systems: http://en.wikipedia.org/wiki/First_to_file_and_first_to_invent


text:
GoECart.com Releases True Search Engine Friendly Shopping Cart Solution
New York City, NY. – March 1, 2005 - Manish Chowdhary, CEO of GoECart.com said "The latest version from GoECart will make life easier for those who are still waiting for the search engine crawlers to visit their store. Features like user defined search engine friendly files names and header tags for all categories, subcategories and product pages, alt tags for product images; provision for unique title and meta tags for all pages and clean code will all enable GoECart powered online stores to achieve top search engine rankings even for the most competitive keywords. End of URLs with long dynamic query strings should allow the spiders to crawl deep into the product catalog and provide a definite boost to the search rankings of our database driven stores." GoECart has made major modifications to its software technical architecture in order to bring these new capabilities to the market."
A recent survey found that search engine beat all other media avenues in driving visitors to websites, with 77% of online users employing search engines to find websites. Furthermore, 78% of users will abandon their query if the first three pages of results do not yield an answer to their query, and fully 33% of users believe companies whose websites are found in top search results are a major brand in their specific product/service category – indicating that top rankings transmit brand equity. Therefore, a website must be found prominently within the search results of ALL the major search properties in order to capitalize on the behaviors of people searching for product or service solutions online. Search Engine Optimization (SEO) is the most cost-effective, holistic, long-term solution to establishing and maintaining visibility within search engine results. It focuses on relevancy of content, which will always be the most important factor used by search engines in displaying a site in their search results.
High visibility in natural search results is critical to online store operators, especially given the fact that CPC (Cost per Click) rate is rapidly rising for the paid search listings on all major Pay-Per-Click (PPC) search engines. Database driven shopping cart solutions have always challenged the search engines, leading merchants to rely on paid advertising to drive traffic to their online store or to live with the inflexibility of a static product catalog. By eliminating these barriers, GoECart believes that improved organic rankings will immediately translate into higher sales and profits for its merchants and give them an additional competitive advantage. Beta users of the v5.0 system have exhibited great satisfaction and provided plenty of positive feedback, which has further strengthened this offering.
Besides the SE friendly features, GoECart shopping cart solution has easy to use store authoring tools, full inventory management and robust back end features, integration with all leading payment gateways and shipping carriers and backed by world-class customer service and support. GoECart's 30-day no obligation free trial allows store operators to try the fully functional GoECart solution before they buy.
The latest version of GoECart also has other new functionalities like provision to send and redeem Gift certificates through email or paper, customized HTML templates and better product import facilities. Newly added soft goods module enables electronic delivery or instant download of digital goods.
About GoECart
GoECart.com is a leader in on-demand e-commerce applications and services. GoECart is one of the most comprehensive, yet cost-effective e-commerce solutions available on the market today. The company serves a diverse customer base ranging from single-person operation to Fortune 500 companies. Visit www.GoECart.com or call 877-243-3612 toll free for more information.


text:
- Videos
- Home
- Energy & Power
- Construction & Mining
- Water & Environment
- Logistics
- Finance
- Manufacturing
- Magazine
- Events
- Buyers' Guide
The Kenyan government has planned to construct three power plants to exploit steam in the Rift Valley, the Geothermal Development Company (GDC) has revealed
The GDC said it will drill 120 wells in the first stage of the project, with the three plants expected to generate 300MW of power by 2018.
"A period of 24-36 months will be provided for power plant construction," read a statement from the company.
Suitable investors for the project will be expected to bring in a total of US$400mn for the development, however the Kenyan government would not promise risk guarantees.
It encouraged potential investors to find funding from organisations such as the World Bank's Multilateral Investment Guarantee Agency.
Kenya currently has 1,664MW of capacity, while there is a demand of about 1,410MW which is still rising.
The government recently said it wanted to add 5,000MW to Kenya's power output by 2017 to drive economic growth even quicker, which is set to increase power demand to 15,000MW by 2030.
It also said that it aims to cut the cost of power generation by 50 per cent in three to four years, primarily by replacing diesel generation.
Alain Charles Publishing, University House, 11-13 Lower Grosvenor Place, London, SW1W 0EX, UK
T: +44 20 7834 7676, F: +44 20 7973 0076, W: www.alaincharles.com


text:
29 January 2016
February Watercolor Challenge
at 10:55 AM
For this month's challenge, I spent a few minutes browsing through the Google Art Project's watercolor collection. There's some stuff in there that I look at and think, "Really? That got in a museum?" As well as some pieces that are incredibly beautiful. This month's logo features a painting of Conwy Castle in North Wales that I found while browsing. (That's the Welsh spelling, not a misspelling, by the way.) So the first suggestion this month is to spend a few minutes browsing their watercolor collection, and maybe pick a few paintings that catch your eye to come share in the Facebook group. There's an amazing variety of looks that the various artists have persuaded their water color paints to produce for them. As with so many things, spending time looking at copying the work of accomplished artists will give us a boost in our own work; you can't go wrong by studying excellence.
After that, spend a few minutes watching watercolor timelapse videos to see how experienced artists build their paintings. I think it's fascinating to watch how they layer their colors, and I find it helpful to watch them do it, and think about their work as I'm planning my own attempts. Here's a couple, but there are many more on YouTube.
This one is a little bit longer, but it shows the whole process, including how this artist uses the lifting technique that we practiced last month. I think it's interesting how she made the painting "loose" - which made a beautiful final picture.
Next, read chapter 3, Transparency and Opacity from our book. This chapter has more discussion of how to mix colors, and the properties of the two classes of paints, transparent and opaque. Mess around with your colors. Observe how they mix, and what they do on wet paper when placed adjacent each other, as well as what happens when you tip a damp page. Once you have figured out if your colors are transparent or opaque, try building up a few layers, working from light to dark. As with last month's blending activity, remember that this exercise is not about the final product, but rather about learning the behavior of your paint: there are no mistakes, even when the result is not what you were anticipating.
Finally, still working with the artist you selected last month, choose another painting to copy in whole or in part. Remember to bring a photo of your projects to our Facebook group and share your accomplishments so we can cheer for you!
The January challenge can be found here.
No comments:
Subscribe to: Post Comments (Atom)


text:
CBS News Monthly Poll, July 2009 (ICPSR 27801)
Version Date: Sep 9, 2010 View help for published
Principal Investigator(s): View help for Principal Investigator(s)
CBS News
Version V1
Summary View help for Summary
This poll, fielded July 9-12, 2009, is part of a continuing series of monthly surveys that solicit public opinion on the presidency and on a range of other political and social issues. Respondents were asked whether they approved of the way Barack Obama was handling the presidency, foreign policy, the situation in Iraq, health care and the economy, whether they thought things in the country were on the right track, their rating of the national economy and whether they thought the economy would get better. Respondents were also asked questions about the economic recession including how long they thought it would last, whether they believed the stimulus package made the economy better, whether the stimulus package would make the economy better in the future, whether the federal government should spend money to stimulate the national economy, whether it was acceptable to raise the deficit to create jobs and stimulate growth, and whether the federal budget deficit affected the respondent's family's financial situation. Several questions about health care were asked including whether President Obama would be able to bring about significant health care reform in his first term, whether respondents would favor government administered health insurance plans, and whether the respondent would consider public health care that anyone could join at any age. Opinions were sought about Sarah Palin, whether respondents heard about her resignation as Governor of Alaska, the reason she resigned, whether she would have the ability to be an effective president, whether the media was harder on her than other political figures, and whether respondents thought she would run for president in 2012. Other topics that were covered included, the wars in Iraq and Afghanistan, North Korea's development of weapons, Michael Jackson, the United States space program, marijuana, Barack Obama's Supreme Court Justice nominations, how the federal government should use taxpayer's money, how the deficit should be handled, personal finances, and job security. Demographic variables include sex, age, race, marital status, education level, household income, political party affiliation, political philosophy, perceived social class, religious preference, whether the respondent considered themselves to be a born-again Christian, and voter registration status and participation history.
Citation View help for Citation
Export Citation:
Subject Terms View help for Subject Terms
Geographic Coverage View help for Geographic Coverage
Distributor(s) View help for Distributor(s)
Time Period(s) View help for Time Period(s)
Date of Collection View help for Date of Collection
Data Collection Notes View help for Data Collection Notes
The data available for download are not weighted and users will need to weight the data prior to analysis.
The CASEID variable was reformatted in order to make it a unique identifier.
A truncated value label in variable EDUC was corrected.
This data collection was produced by CBS News, New York, NY.
Sample View help for Sample
A variation of random-digit dialing using primary sampling units (PSUs) was employed, consisting of blocks of 100 telephone numbers identical through the eighth digit and stratified by geographic region, area code, and size of place. Phone numbers were dialed from RDD samples of both standard and land-lines and cell phones. Within households, respondents were selected using a method developed by Leslie Kish and modified by Charles Backstrom and Gerald Hursh (see Backstrom and Hursh, SURVEY RESEARCH. Evanston, IL: Northwestern University Press, 1963).
Universe View help for Universe
Persons aged 18 years and older living in households with telephones in the United States.
Unit(s) of Observation View help for Unit(s) of Observation
Method of Data Collection View help for Method of Data Collection
Mode of Data Collection View help for Mode of Data Collection
Original Release Date View help for Original Release Date
Version History View help for Version History
- CBS News. CBS News Monthly Poll, July 2009. ICPSR27801-v1. Ann Arbor, MI: Inter-university Consortium for Political and Social Research [distributor], 2010-09-09. http://doi.org/10.3886/ICPSR27801.v1
2010-09-09 ICPSR data undergo a confidentiality review and are altered when necessary to limit the risk of disclosure. ICPSR also routinely creates ready-to-go data files along with setups in the major statistical software formats as well as standard codebooks to accompany the data. In addition to these procedures, ICPSR performed the following processing steps for this data collection:
- Performed consistency checks.
- Created online analysis version with question text.
- Checked for undocumented or out-of-range codes.
Weight View help for Weight
The data contains a weight variables (WGHT) that should be used in analyzing the data. According to the CBS News Web site, the data were weighted to match the United States Census Bureau breakdowns on age, sex, race, education, and region of the country. The data were also adjusted for the fact that people who share a telephone with others have less chance to be contacted than people who live alone and have their own telephones, and that households with more than one telephone number have more chances to be called than households with only one telephone number.
Data in this collection are available only to users at ICPSR member institutions.
This study is provided by ICPSR. ICPSR provides leadership and training in data access, curation, and methods of analysis for a diverse and expanding social science research community.


text:
Holocaust Education Successfully Reaches 93% of the Public and Charter Schools in Pennsylvania
November 9, 2017
The Pennsylvania Jewish Coalition (PJC) commends the Pennsylvania Department of Education and the Act 70 of 2014 Task Force (comprised of professional educators focused on the Holocaust, genocide and human rights violations) on reaching their goal of having guided over 90% of the Pennsylvania public and charter schools to offer instruction on the Holocaust and related issues in their curriculum. This morning the Pennsylvania Board of Education approved the survey of the state's public and charter schools, confirming that 90% of these schools are sensitizing students to the Holocaust, genocide and human rights violations through such instruction. The Board likewise made recommendations for the Commonwealth to continue to update resources and training on these subjects.


text:
Pawns are pushed and swords clash in Human Combat Chess
As someone who was both on the chess team in high school and a fencer in college, I truly wish human combat chess was a real sport. I'd be its biggest fan.
As it stands, I'll just have to take in the annual performances by Six Elements Theatre. Human Combat Chess is like the mutant spawn of professional wrestling and the Society for Creative Anacronism. Two teams of 16 face off over a giant chess board. Pieces move in normal fashion -- until it is time to capture another piece.
See also: Human Combat Chess: Check, and en garde[jump]
There's nothing automatic here. The two pieces face off in a bit of stage combat, using a bevy of weapon choices, from the ancient trident and net to the not-quite-as-ancient dueling rapiers.
It makes for a fast-paced evening of entertainment, with touches of chess strategy mixed in with moments of violence.
This year's finals pits the Dragons, who are sort of the New York Yankees of the Midwest league (lots of talents without as much chemistry), against the Phoenix. All the while the play-by-play announcers give us a sense of what's happening before us while clearly rooting for one side (the Phoenix).
All of this made for a heady mix, where the combatants could wear knee-high leather boots, a sash, and an Under Armor compression T-shirt and not look out of place. As the game progressed, we learned a bit about the history of combat chess (it goes back centuries; and there are leagues all over the world), and some the distinct rules that are fun to work out as the fights go on.
The performers do have variable skills, so the combat at times felt uneven. A slick brawl could be followed by a slower and clumsy battle that didn't have the grace or violence of the previous one.
Also, while the Wesley Center has a good vibe for the event, it lacks in acoustics. That made a lot of the play-by-play hard to understand. That's a shame, because there were funny things happening when I could hear it.
Though the overall event was fun to watch, a bit more story throughout the experience would go a long way toward making it more compelling. Some of this was played out in the combat itself, but a few "sideline" interviews or pronouncements from the kings could give it some real unity.
Human Combat Chess Through July 19 Wesley United Methodist Church, 101 E. Grant St., Minneapolis $15-$18 For tickets and more information, visit online.
Got a tip? Email us at Dressing Room.


text:
BRICS Bank to provide its first loan to India on Solar project
Posted on:01 Mar 2016 09:47:10
01 March 2016 Current Affairs: The New Development Bank set up by BRICS countries aims to lend up to USD 2 billion this year starting in about two months and the multilateral lenders first loan to India could be for a green solar energy project, its president K V Kamath said. "For this year, if we can approve one-and-a-half to two billion dollars I will be happy. We are six months into setting up the bank. We do not want to take steps which are too fast," Kamath told PTI.While the bank is in the process of finalising its set of loans to green projects from each of the BRICS countries -- Brazil, Russia, India, China and South Africa -- India's first loan could be for a solar project, the eminent banker hinted."The projects we are looking at are all green projects. They are primarily in solar. A variety of initiatives were placed before us by the government," he said. Kamath, 68, said the bank is also looking for water projects and thereafter road projects to fund. The bank will release the first set of loans by April this year.


text:
Customize your Chicago catering menu
When you host your meeting or event at Kimpton Hotel Allegro, the stunning space isn't the only thing you'll ooh and aah over. Featuring the culinary handiwork of our culinary team, our customizable catering menus are designed to dazzle. Enjoy mouth-watering Breakfast Buffets brimming with pastries, bagels, and fruits and savory Lunch Buffets, with Cajun-spiced chicken breast and Italian beef while ending your day with lavish plated dinners and sumptuous confections.


text:
Sparkly Mason Jar
May 9, 2012 § 4 Comments
Needless to say, I love trying to come up with different ways to re-invent the use of the Mason Jar. This is my second post about mason jars and I feel that anyone can find a cool place in their dorm or home for this craft. I have a weird obsession with sparkles and glitter…
The mason jar on the far right is from my DIY post on tinting mason jars. The two on the left are what I'll be explaining in this post. Some of the different ways you can use mason jars include; flower vase, votive holder, makeup brush holder, pencil/pen holder, container for cosmetic items (cotton balls, Q tips, etc.), keeping change, etc. So first, here are the supplies you will need.
Mason Jar: $10-$12 (They usually come in a pack of about 9 or 12)
Mod Podge: $10 (Like I always say, invest in this now and it will last forever for so many different crafts!)
Glitter: $4.99 (I bought the large size, the smaller one would have been more than enough and it was $2.99)
Paint Brush: $1.99
Small Bowls: $FREE
Tape: $FREE
Rubbing Alcohol: $FREE (I cleaned the outside of the jar to make sure the glitter stuck well)
Now, put the tape on the mason jar where you do NOT want the glitter. You can get as creative as you want with this step. I only made two of the sparkly mason jars so I made them contrasting.
Next, paint the mod podge on to the parts of the mason jar that is not covered by tape. After that sprinkle the glitter on the mod podge. If you have a large enough bowl, I would reccomend rolling the mason jar in glitter. This would result in even coverage and less mess!
Let the glitter dry a little. I let mine sit for about 10-15 minutes but it depends on how much mod podge you used. Next, apply another coat of mod podge on top of the glitter to ensure that it stays put.
Once again, let the modge podge dry again. The magic of mod podge is that it becomes clear when it is dry. The trick with this project is to take the tape off before the mod podge and glitter are completely dry so that you can still pull it off the mason jar.
After you take the tape off of the mason jar, let them sit until completely dry. Individually these mason jars cost about $2.99 a piece, this cost will change if you already own some of the supplies like mod podge and a paint brush!
How would you use a sparkly mason jar? Would you use a different pattern to apply the glitter?
Happy Crafting!
§ 4 Responses to Sparkly Mason Jar
Im thinking cut pieces of tape or paper into hearts and then glitter the rest of the mason jar. Would be especially cute if you're planning to put candles in it ecause it would shine out in hearts 🙂
[…] If you liked this craft be sure to check out my tutorial on Tinted Mason Jars or Glittered Mason Jars […]
[…] Crafty Collegiate – Glitter Mason Jars. My attraction to glittery Mason Jars never ceases. I love these! […]


text:
Install the leading
smart home solution
Loxone offers the perfect opportunity for companies that are active in the smart home industry to grow their business. With Loxone, you'll have a reliable and future-proof partner with a market leading solution. Whether you're an electrician, manufacturer of prefabricated houses, architect, M&E designer or solar specialist; get in touch to find out how you can benefit from a strong collaboration with Loxone.
How do I become a Partner?
We think our Partner program is pretty special, and as such, we're looking for dedicated Partners who love smart homes as much as we do!
Great Loxone Partners look after their customers all the way through their Loxone Smart Home journey – from the consulting and planning stages, to the installation and all the way through to aftercare support and follow up.
Electricians and/or those who have an established home automation arm of their business are welcome to apply to join the program. Please note that membership of the Loxone Partner program is not guaranteed and all applications will be reviewed.
Blinds/Shading specialists
M & E designers
Solar & PV installer
Heating engineers
Security providers
AV installers
System designers & integrators
Hear from our current Partners
Since partnering with Loxone, business has never been better. We've achieved far smarter, better quality and more reliable smart systems using Loxone automation products.
With such leverage to hand, we pride ourselves in bringing affordable smart homes to the UK and beyond and our mission is to provide a reliable and constant service.S. Knight
We had tested a variety of smart home manufactures extensively and arrived at the conclusion that Loxone was the best option.
We found that the equipment's ease of use was the best in the market. Together the reliability and the programming of the system were also impressive. The value for money that Loxone could offer represented a great selling point for our customers.A. McCully
I have personally been fitting Loxone automation for about 3 years, Everything about Loxone is incredible, From the ground up… The staff are there to help you, from order process to technical support, Their products are what we all want, also at affordable prices. I honestly believe automation and control is the future, and being part of the Loxone community, this is all achievable. I have no concerns or apprehension when specifying Loxone… I also have Loxone at home.M. Nicic
Training & education
From training in-house to numerous online resources, we offer many possibilities to learn about Loxone. Immerse yourself and become a Loxone Smart Home professional.
Other industries
Property developers
Business Focus:
Property development, prefabricated house manufacturing and home building
Designers & architects
Business Focus:
Architecture, interior design and consulting
If you are a member of the press seeking further information and materials about the Loxone Smart Home, you'll find all of our latest press releases and resources as well as the relevant contact details over in our press section.
If you are a member of the press seeking further information and materials about the Loxone Smart Home, you'll find all of our latest press releases and resources as well as the relevant contact details over in our press section.


text:
Thanks to Lilly Pavlak (CZ/CH), winner of a Distinguished Achievement Award at this year's IBMA World of Bluegrass (WOB) in Nashville, TN, for many photos - and a link to even more photos - from World of Bluegrass 2011.
The photo on the left shows the members of Monogram (CZ), who took part in the official WOB showcase programme, enjoying the sun in downtown Nashville. Sixty-four of Lilly's IBMA 2011 photos can already be viewed in a Facebook album, and a second album is likely to follow.
Update 17 Oct.: A further 129 photos by Lilly can be seen on the second album, here.
Southern Raised – Another World
2 hours ago


text:
Wherever evil is lurking and danger is a foot… Lily & Frog's Super Hero Capes are there to save the day.
My kid, Zach, has a mild (HUGE) obsession with Super Heroes… Unfortunately, I can't take the credit for getting him hooked. I don't know very much about Super Heroes, but I can certainly sew a Super Hero Costume and Cape! Tap on the pictures below to read through my DIY instructions…
Super Hero Lair of Capes:
We are always adding NEW Super Hero Capes, if there is a cape without a link, it will be up and running in a few days, thank you for your patience.
Each Lily & Frog Super Hero Cape is custom-designed, so no two Super Hero Capes are ever the same. I will be happy to discuss with you a Super Hero Cape which works best for your little Super Hero In-the-Training while maintaining a classic pattern with a wholesome design, finished off with a sprinkle of Lily & Frog flair! Super Hero Capes are available in ONE size, toddler age 3 size, unless otherwise stated by you. They are also available in a snap neck closure or a ribbon neck closure. Each is Super Hero Cape is available in 100% cotton flannel fabric in an assortment of colors, the cape is double sided in a color of YOUR choice while the underside is lined in white and the shield is designed using a coordinating felt… Starting price for a custom designed Super Hero Cape is $25.00 and may vary slightly from there.
Lily & Frog Super Hero Capes are only available through contact with Elizabeth via firstname.lastname@example.com. After details of the Super Hero Cape have been exchanged, the final checkout will be done through our online shoppe. For any questions, please contact Elizabeth directly via email@example.com.


text: Manga with a heavy dose of cute, this debut introduces a shy teenager who is transformed into a reckless heroine by a bicycle with unusual properties. Just a day or so after Aki come across an old bike in the garage that—with a mighty FWOOOOSH—changes her school uniform to high boots, a short dress and a snazzy helmet, a gang of masked bicyclists embarks on a crime spree. Somehow managing to overcome her reluctance, off Aki pedals to do battle. Outfitting her lissome young daredevil with a hot boyfriend/sidekick, a cheery kimono-clad Grandfather to fill in the back story and a "Spirit Bike" with a front fender that turns into a giant snake at need, a toy elephant's head on the handlebars and the ability to zoom along at super speed, the author propels the tale through many sudden jumps and inset-crammed pages to a climactic race, the dismaying revelation that the gang's leader is a member of her own family and a juicy closing clinch with the aforementioned sidekick. Bound on the left edge rather than the right, but otherwise indistinguishable from its imported cousins, this should find a ready crowd of action-oriented shojo fans. (Graphic novel. 11-13)


text:
Free Home Evaluation in Toronto
Today we have a special announcement for all our blog readers. We at Murji Team are dedicated in providing the best real estate service in the Greater Toronto Area. For absolutely no charge we are offering a free home evaluation.
Our free home Evaluation is different from others and is not an automated report.
Reasons Why You Should Opt-In For Our Free Home Evaluation
- One of our agents will personally work on a competitive market analysis and come up with a personalized free home evaluation for your home in Toronto.
- We will meet up with you (upon your request) and go through your home evaluation.
- We will include a detailed list of just sold and just listed properties in your street.
Listings News


text:
Altuglas® Signature Range, the magnificent alliance of acrylic glass and fabric
Altuglas® Signature is the result of the research of Altuglas International
This new Altuglas® Signature sheet is the top choice design material for architects and designers in the creation of boutiques, point of sale advertising, interior design, or in the construction of all types of buildings.
With LEDs along the edges, Altuglas® Signature has amazing optical effects. Depending on the power and illumination angle, a close mesh will make the sheet opaque while non-woven material unveils its 3D effect.
It is also possible to customize Altuglas® Signature by putting in an order for a fabric. This allows clients to create a unique design based on technical compatibility.
- Altuglas® Signature has the traditional features of acrylic glass in addition to the high-tech properties of textiles. Twice as light and transparent as glass, this sheet has no distortion effects, while offering exceptional light transmission.
- Altuglas® Signature meets all the requirements of the necessary material tests in the fields of architecture and design, such as the sand bag or impact and heat resistance.
- Altuglas® Signature is thermoformable (as far as material goes) and does not bleach. It can also be tinted, smoothed, pierced, screwed, or sawed. This product works like wood, without the constraints of fiber.
- Altuglas® Signature is resistant to chemical products thanks to the Altuglas "Essential" process and to UV rays through its special formula.


text:
Results tagged ' Ozzie Guillen '
Feeling good right now; let's keep it going
What's up, everyone? If you can't tell, I have been pretty happy this last road trip. This actually might be one of the easier blogs I have written. Everything is easier when you are winning. We are back in Chicago and, man, do I love this city, especially when the weather is as nice as it is today.
Great job by the guys in Baltimore against a team that can hit. What I liked so much about this series is even in the games where we gave up the lead, the team kept pushing and coming back. That's a great sign. It really shows how our guys aren't going to give up or give in. There are so many games left to go, and it's so important that we don't give in at all. Even the game on Wednesday that we lost in extra innings, we came back and put up a good fight. I guess as a manager that's all I can ask for.
When you win games, it seems like everyone has been playing great. At this point in the season, you can really throw the stats out the window and focus on winning games; that's all that matters. Our focus is on winning the division. I don't care if we don't get to .500. If we win the division, I will be happy.
We have Kansas City coming into town starting today, and they are a pain in our butts. They always play us well and they can swing the bat, too. It has come to my attention that we play better baseball on the road and have a tendency to play better against teams over .50o. … I don't have an answer to this, but I hope the trend stops right now. We have to have a good weekend here at home because we get Cleveland next week before the American League Champs come to town. So sit back, relax and strap it down (hahaha). Yes, I know all the things Hawk says, but this weekend we are right in the hunt and first place is up for the taking. I hope to see The Cell packed and loud for this homestand.
See you all there!
— Ozzie
That TriStar event was a good time!
That Twins sweep put me in a better mood
Hey, everyone, are you starting to feel like it's easier for me to write these blogs and talk to you guys when we win games? Well, it definitely is. I'm in a great mood this morning in Baltimore and decided to write one of these up. Actually, my room here is right over Candem Yards. I can actually see the field right now.
Anyways, it was a great sweep of the Twins this weekend because, as you all know, they are always a huge pain for us. Those guys always play so well against us; we finally got them. I'm not going to lie, it's a pretty good feeling. I just hope this starts a trend of us playing better and more consistently, and this series against the Orioles would be a good way to continue it.
Jake Peavy did a great job yesterday and got some help from Brent Lillibridge, and the defense definitely threw some leather around this weekend. The new kid with all the hair, Zach Stewart, did an awesome job as well this weekend. I hope he continues to throw the ball like that. Anytime you sweep a team, especially on the road, it seems like everyone needs to contribute, and we got that. Alex Rios was crushing he ball, and of course, "Q" (Carlos Quentin) continues to swing a hot bat.
I will have time to write you guys after this series with Baltimore and hopefully answer some more of your questions. I had a great time this past Saturday at the TriStar National Memorabilia Convention thanks to Bobby and all the guys that worked there; it was a lot of fun. I will have pictures up for you guys here soon on the website. My son and I had a great time, and I hope to be back doing that every year.
Thank you all for the support and talk to you guys soon!
— Ozzie
Next up, the Yankees visit The Cell
OK, well we didn't end the weekend the way we wanted, but we all know the big boys from the AL East are very tough. It's hard to beat good teams, and the last two days, we just didn't get any timely hits like we did on Friday. To be honest with you, I don't really care whether we win by one run or 10; right now, winning is the most important thing. I would of course rather it be less nerve-racking, but that's why this job is so fun. The tension you feel and the emotions that come with this game make it the best in the world. But when you aren't getting the big hit, it makes everything else so much more important. Every pitch and every decision could be the ballgame, but that's what it means to play this game in the race for the division.
We get the Yankees in town tonight, and I think CC Sabathia is going for them, so that should be interesting. We have battled tough this year against the league's best, and I expect tonight to be no different. These are the teams we have to be beat to be considered elite. It will be nice to congratulate Derek Jeter on his 3,000th hit in person. I have always been a fan of his. It's also going to be nice to see Freddy Garcia. I'm glad he isn't pitching against us with the way he has been pitching lately. I also hate facing him because he is family. Freddy is married to my wife's niece, and it's hard to root against family. Also, we get to see Andruw Jones, as well, which is always a good time.
This should be a great series for the fans, and I think our boys will bounce back like they have done all season long. See you guys at The Cell.
— Ozzie
On my mind on this off day: Cut into that lead
Well, that's the way you want to start a homestand. We need to just keep winning series.
First of all, I want to wish Mark Teahen and Edwin Jackson the best of luck. I know they will be just fine, and I appreciate what they did for me. They always respected my decisions and the coaching staff's opinions, so I wish those guys the best of luck from here on out.
If you continue to win series, you give yourself a chance over time to keep gaining ground. We had a couple of sloppy mistakes, but as long as you find a way to win, it doesn't really matter.
It's only going to get tougher with Boston coming into town, and last I checked, they were a pretty good ballclub. But it's hard not to like your team when you've got guys like John Danks giving the performances like he did yesterday; that guy has some stones. Chris Sale did a great job again, and I'm glad we picked up some bullpen help to support Jesse Crain and Brian Bruney. Now we can give those guys some rest from time to time.
We get another off day today, and I'm trying to get out and play some golf, but this rain isn't doing us any favors. My family is headed to Cirque du Soleil tonight. I have seen their show before, but I'm excited to see what new they have come up with this time. It's easy to enjoy the days off, but I want to continue to cut into that lead as much as we can. As you know, the next week is going to be a big test for us, so I'm curious to see how we respond to the challenge. I have no doubt the park will be filled for the Red Sox and Yankees series.
Should be fun.
— Ozzie
Big series starts tonight — we're ready!
Well, we are finally back home after what turned out to be a pretty good weekend in Cleveland. That's the way you end a long road trip on a good note. We kinda stumbled a bit in Kansas City, but the guys responded and showed what they were made of.
We did get a little break there yesterday with the center fielder making an error, but like I have said before, I would rather be lucky than good (haha). We got a couple great outings by Edwin Jackson and Gavin Floyd, and everyone in the bullpen did a great job. When you get that kinda pitching along with some timely hitting and great defense by the old timer Omar Vizquel, it usually leads to a win. Now it's time for a long homestand.
Not exactly sure what the numbers are, but I think we have played better on the road this year than at home. I hope that changes because this homestand is going to be a test, and we need to defend out home field. We start out the homestand with the Tigers tonight, a team we need to beat. Hope to see you guys out there.
I also want to say congrats to my man, a friend and someone I played with and against — Roberto Alomar. He was the best and smartest player I ever saw. Also, congrats to Bert Blyleven, as well. These guys both represented the game of baseball the way you should, and I'm very happy for them!
— Ozzie
Day off in Cleveland; time for a Q&A
I think it's safe to say it's easier to answer your questions than write a blog on this day off in Cleveland. It's definitely not the best day off, but I looked at some of your questions and thought now was a good time to answer:
Q: Hi, Ozzie. I am a lifelong Sox fan living in Minnesota and am desperate for a Sox series win against the Twins. Anyway, was just wondering if there's any topic you won't talk about in public. Is anything off limits to Ozzie Guillen? — Brandon H. (St. Paul, Minn.)
A: Well, I would also like to beat the Twins, but they have just had our number, I guess. Weird things happen in baseball; sometimes it's just the way it goes. No topic is off limits but my personal life — meaning my wife and my kids are what's sacred to me.
Q: My friend O.G. — congrats on the website. Great way to keep in touch with the people who follow you. Keep doing what you're doing. — Carlos C. (Caracas, Venezuela)
A: Thanks a bunch. The idea behind the website was to stay in touch with the fans and anyone who wants to reach me.
Q: Hey, Ozzie, any suggestions on some places to take her after the game for a few drinks besides the Bacardi Bar? — Eric C. (Joliet, Ill.)
A: Well, Chicago is Chicago, but I would take her down to Buffalo Wings & Rings on 34th and Halsted. My close friends and kids have been going there and I stopped by a couple of times; good place with some very good food. You will be hearing more about this place soon, trust me.
Q: What is your favorite ballpark to visit when your team is on the road? — Russelle D. (Fremont, Calif.)
A: Well, my favorite place to visit is Kauffman Stadium in Kansas City. I managed my first game ever there and it has gotten a lot nicer since then. Only problem is they seem to play well against us, and I'm not a fan of extra innings …
Q: Mr. Guillen, what is it like to wake up every morning being so awesome? — Jeff P (Rockton, Ill.)
A: Hahaha. Well I'm glad you think so. Every morning I wake up and my wife sees me, I hope she thinks the same thing you do. I'm just happy to be blessed and healthy; everything else happens for a reason.
Q: Ozzie, I would like to know — what is your view on Interleague Play? It seems like a lot of people in baseball have a dislike for Interleague. I personally believe it's fun. I mean, when else will we see Philles vs. Red Sox, or White Sox vs Cubs? — Seong O. (Las Vegas)
A: I don't mind it, to be honest with you, because it brings people to the stadiums and sells tickets. If it sells tickets, then it makes sense to everyone. But I do think the DH should maybe alternate every year in Interleague Play.
Q: When you are mad at an umpire, do you ever swear at him in Spanish? If so, what is the usual reaction? — Danielle G. (Sycamore, Ill.)
A: Haha. Maybe I do sometimes. In the heat of the moment, you say crazy stuff. And believe me, I run out of bad words in English very fast, so I usually say the same ones over and over.
Q: What do you think about Jim Riggleman resigning in the middle of the season AND over his contract? Thanks, Ozzie! — Jeffrey H. (Minneapolis, Minn.)
A: Well, I believe he had his own personal reasons for doing what he did. But as I have said before, those 25 guys and the coaching staff would be hard for me to walk away from. So to each his own, but I don't see myself being able to do that.
Thanks for all your questions. My day off in Cleveland just got a little better. Come tomorrow, I hope we are ready to kick some butt and come back home on a winning note!
— Ozzie
Kids skills camps a great success
As most of you know, last week during the All-Star break I held my first-ever kids skills camps. The experience was incredible, and if the kids had half as much fun as I did, I know they had a great time, too. I owe a special thanks to the Bulls/Sox Academy for their help in putting this together as well as to all of the parents who brought their kids out. I will, without a doubt, be doing this again, but for now you can check out the pictures I have posted and see what the camps were all about!
– Ozzie
Happy for my boy Carlos Quentin
I hope everyone had a very happy and safe 4th of July weekend. Happy birthday to the U.S.A., and thank you very much to all the people who serve this country!
Our weekend wasn't too bad. We took two out of three from the Cubs and won another series. Last night, we won on a balk against the Royals — a "balk-off." Sometimes it's better to be lucky than good, and right now, I'll take them anyway we can get them.
The series vs. the Cubs ended on a bad note because we couldn't score any runs off of Rodrigo Lopez — a guy I felt like we should handle — but this is baseball and sometimes crazy things happen. The All-Star teams were announced over the weekend, and I'm very happy for Carlos Quentin — he deserves it. I also think Paul Konerko was very deserving because he has been amazing for us the entire season. I know what it's like to try and pick reserves for the All-Star team and know what Ron Washington is going through. That is not an easy job.
We get the Royals and Twins this week, I think, and yesterday started a stretch of 19 straight games against our division. The Royals always seem to play us very well, and it's time for us to start swinging the bats a little better to close the gap before the break. The next 3 weeks are either going to have us out of it or right in the thick of things for the home stretch. Hopefully we can make the right adjustments and continue to win ballgames.
See you guys at The Cell!
— Ozzie
It's so much easier to blog when we win
Well, I'm definitely a big fan of the city of Denver. Very nice city, and you can walk to the park and back to the hotel after the game; it's so close. I also want to say Happy 27th Birthday to my oldest son, Ozzie Jr. We got to celebrate a little late last night when I got back into town. By far my favorite job in the world is being a dad to my three sons.
Why does it seem so much easier to write one of these blogs after we win a series? Or in this case, after we just won back-to-back games? I'm very impressed with yesterday's games — the fact that we kept battling, and when it looked like we were done late, we kept pushing and got the job done. Loved it that Gordon Beckham laid down that bunt that gave us a better chance to score those runs, and Juan Pierre was clutch the entire series. When you work as hard as JP does, only good things will come from it.
Jake Peavy was very solid even after the first-inning home run to Troy Tulowitzki, and I will say it again about the bullpen — WOW. Seems like I say it in every blog, but those guys continue to give everything they have for this team, and it's been impressive.
Now we move into the North side of town. Kind of cool because now I live closer to Wrigley Field than The Cell (haha), so I won't be getting lost anymore (I hope). Wrigley on a weekend is always exciting and maybe even a little more so now that both teams have won back-to-back games. Should be interesting to see how it plays out. I'm sure fans will be into it, and I can't wait to get 4th of July weekend started the right way.
I enjoyed catching up with Mike and Mike on ESPN Radio this morning. Those guys are the best in the mornings! See you guys at Wrigley this weekend!
Hey, Chicago, what do you say …
— Ozzie


text:
Accessibility InformationThere is a path that leads from the carpark to the Grotto. The first 80 metres of the path has timber decking with timber
The Grotto
Change of conditionsAdd change of condition
No change of conditions applyView all changed conditions for Port Campbell National Park
Accessibility Information
There is a path that leads from the carpark to the Grotto. The first 80 metres of the path has timber decking with timber edging. Some of the timber decking has gaps of up to two centimetres wide, which may be hazardous for some walking frames.
After the first 80 metres the path changes to a surface of compacted small to medium crushed rock.
The first designated viewing area of The Grotto is approximately 300 metres from the carpark. This section of the path is relatively level, except for a small section with a gradient of about 1:14. The viewing area consists of a timber deck and has horizontal timber safety railings.
The main designated viewing area of The Grotto is approximately 40 metres further down the path from the first viewing area. This section of path becomes quite steep, with a gradient of approximately 1:10. As a result, the path section after the first viewing area is not recommended for wheelchairs or strollers or visitors with limited mobility.
At the main viewing area there is a staircase leading down to a beach-level view of The Grotto. This is not suitable for strollers, wheelchairs or visitors with limited mobility.


text:
Blood Orange and Star Anise - Braised Pork Shank
2 Tablespoons Olive Oil
2 small onions, diced into one half inch pieces
2 small carrots, diced into one half inch pieces
2 cloves of garlic - minced
4 stalks of celery, diced into one quarter inch pieces
1/2 lb pound of pancetta, diced fine
5 star anise, whole
1/2 bottle of red zinfandel, or another good red wine
2 quarts of chicken stock
4 pork shanks, organic if you can find it
1 teaspoon ground fennel
2 Tablespoons canola oil
5 blood oranges
1. Preheat your oven to 300 degrees. Heat the olive oil in a large skillet and saute the vegetables and pancetta until soft. Add the star anise and saute for 5 more minutes. Add the wine and stock and bring to a boil.
2. Season the pork shanks with the fennel, salt and pepper. In a large roasting pan, heat the canola oil. Brown the pork shanks on all sides. Then add the stock mixture to cover, cover all with foil tightly and put into the oven. Roast this for 3 hours, or until tender. Cool in the sauce, overnight.
3. Next, remove the shanks from the sauce. Bring the sauce to a boil, then remove from the heat. Strain the solids. Pour the sauce over the shanks reheat at 400 degrees, for approximately 25 minutes, while making sure to baste the shanks often.
4. Serve the pork shanks with the sauce, and scatter with blood orange segments.


text:
Welcome to the Framer's Insurance Open Six Pack brought to you by Bottom Line Jay in Boston! Who's got the edge this week? Tiger vs. Phil, Rickie vs. Davis. Who's got great odds this week? Who might be my long shot? Click my link to find out in my detailed article on Bleacher Report!
No matter who you like, have a great weekend and hit 'em straight!
Tuesday, January 25, 2011
The 2011 Farmer's Insurance Open at Torrey Pines
Posted by Bottom Line Jay at 11:47 PM
Subscribe to: Post Comments (Atom)


text:
Sign up for new arrivals and promotions North Face clothing!
Why Do You Want North Face Jackets From Our Online Outlet.
- Worldwide Shipping
- Fast shipping 5-7 days. And we generally have to order gift-wrapped. So you do not want to spend the customs tax.
- Best Price Guarantee
- Our North Face on the internet retailer offers the Beat Price Guarantee.Just appreciate the luxury of exquisite North Face at excellent discount here!
- Earn Free Gifts
- It truly is fantastic news for every buyer to earn a lot of free presents just like North Face after you order greater than thirty times.
- 30 Days Guarantee
- You are able to return it in 30 days for anyone who is not satisfied with our North Face sale. We will refund the money to you.
- Why not become our customer now?
- Registering to become a member will take only minutes. With your account, you could take component inside the a variety of services we supply to you. You will receive free assistance from our sale representatives, they're going to answer all your questions and advise the most decent solutions to you. Get begin obtaining online now!
North Face will be the fashion leader supplying North Face jackets and coats for men, women and children. The exquisite North Face jackets characterized by lightweight and cozy. You can expect to surely get enjoyment from our comprehensive North Face jackets sale, diverse designs and colors.
- Home
- | About Us | Privacy Notice | Shipping & Returns | Conditions of Use | Contact Us | FAQ | Site Map


text: "This best thing I EVER COULD HAVE DONE for my health, and my body, is call the Medifast Weight Control Centers. I went from a size 11 to a size 7 in pants. I went from a L to a M in shirts. I got my body back!!! If you have 30 pounds to lose like me, or 100 pounds, the Medifast Weight Control centers can help!!! You meet with a counselor, you get to pick your food, you still get to eat the things you love, and it is proven FAST, SAFE, AND EFFECTIVE weight loss!!!! Before you know it, you get your body back! It was amazing, and I just wish I would have called sooner!!" – Ashlee from The Show on Rock 105.3


text:
Auditions for "The Servant of Two Masters" will be held on February 8, 9, & 10 from 12:30-3 p.m. with callbacks being held Fri., Feb. 10 from 1-3 p.m.
Come prepared to perform a short one- to three-minute monologue. Please, audition not to exceed 3 minutes.
Auditions and performances will be held at:
Shoreline Community College Theater (1600 Bldg.)
16101 Greenwood Ave. N.
Shoreline, WA 98133
Directed by Duygu Monson, "The Servant of Two Masters" will be performed June 8, 9, 10, 15, 16, 17.
TO SIGN UP FOR AN AUDITION, please go to the audition page on the theater website and sign up for a five-minute slot. You will receive a confirmation email confirming your audition time.
We are also looking for students who are interested in tech work to assist in the production. Students can get musical theater performance credits, drama credits, or stage technical credits. Auditions are open to the community, but everyone involved in the production must register for some type of Shoreline Community College credit. Additional questions can be sent to John Nold at firstname.lastname@example.com.


text:
Southern Rail to reinstate services
The thundering mess that is Southern Rail is trundling back into action, and reckon that passengers will notice less delays and cancellations over the next few weeks.
Southern Rail customers, feel free to snort in derision any time you feel like it.
The train company is planning to reinstate over a hundred services - a third of the 300 they cut from their timetable in July.
Even so, the 48-hour strike which has been planned by Southern workers over working conditions is still going to go ahead next week, unless talks are successful in the meantime.
Charles Horton, from parent company Govia Thameslink Railway, says: "We know how difficult life has been for our passengers recently and we are sincerely sorry."
"Our aim has been to bring back as much of the timetable as quickly as we could and for several weeks we've had September 5 as our target to begin the reinstatement of trains."
"We're pleased that we can restore a large chunk of our train timetable for our passengers on this date but we will not be satisfied until the full timetable is running, and running in a punctual way people can rely on."


text:
From: Washington (Nomura)
To: Tokyo
November 20, 1941
#1148. (To be handled in government code)
Secretary of State HULL, in the conversations I detailed in my #1144 [a], expressed his satisfaction that in the last two or three days Japanese newspaper editorial comment on the United States had become calm. This, doubtless, is due to your great efforts.
Since newspaper editorial comment in this country has become extremely circumspect in conjunction with our conversations, no doubt as a reflection of State Department opinion, I would like to have you continue your efforts in guiding newspaper opinion.
Army 25174 Trans. 11/24/41 (2)
[a] S.I.S. #25137 in which HULL says that so long as it is not made clear that Japan is turning toward a peaceful policy, it will be impossible to stop aiding China.
(EXHIBITS OF JOINT COMMITTEE , EXHIBIT NO. 1 INTERCEPTED DIPLOMATIC MESSAGES SENT BY THE JAPANESE GOVERNMENT BETWEEN JULY l AND DECEMBER 8, 1941)


text:
Located just two blocks from the famous Wildwood Boardwalk and it's expansive white, sandy beaches, Esplanade Suites is the perfect place for your next vacation. Whether it's a romantic getaway, or the whole family is together, the Esplanade will meet all your needs and make your stay unforgettable. If you're in town for one of the many concerts or events held at the Wildwood Convention Center, Esplanade Suites is just a few short blocks away.
Hotel/Motel Amenities
- Barbecue grills
- Cable/Satellite TV
- Coffee makers
- Daily maid service
- DVD/Blue Ray available
- Efficiency units available
- Free parking
- Free wi-fi
- Guests under 25 years of age may book reservation
- Heated pool
- Heated rooms
- Kiddie pool
- Largest units can sleep up to 6 people
- Pet friendly
- Pool
- Rooms with microwaves
- Rooms with refrigerators
- Rooms with stoves
- Rooms with toasters
- Rooms with TVs
- Sun deck
- Trolley stop nearby
- Walking distance to bars
- Walking distance to beach
- Walking Distance to bike rentals
- Walking distance to boardwalk
- Walking distance to public park/playground
- Walking distance to restaurants
- Walking distance to shopping
Business Information
|Esplanade Suites
|230 East Taylor Ave Wildwood, NJ 08260
|Visit Website
|Price Range
Lodging Info
|Click to Visit
|Click to View


text:
MOD+DMOC: Automating Administration with Windows PowerShell (M10961)
New – Learn to remotely manage your Windows-based servers with PowerShell 5.1
New – Learn to remotely manage your Windows-based servers with PowerShell 5.1
$1445 CADEnroll Request Group Training
In this course, you will gain the fundamental knowledge and skills to use Windows PowerShell for administering and automating the administration of your Windows-based servers. You will learn how to identify and build the command they require to perform a specific task. In addition, students learn how to build scripts to accomplish advanced tasks such as automating repetitive tasks and generating reports
This course incorporates materials from the Official Microsoft Learning Product M10961: Automating Administration with Windows PowerShell.
Microsoft Official Course On-Demand (MOD) plus digital Microsoft Official Courseware (dMOC) includes three months, 24x7 access to:
Redeem five SATVs for an individual On-Demand course plus digital Microsoft Official Courseware (dMOC). For more information on Microsoft SATVs click here.
Windows PowerShell
Cmdlets for administration
Working with the Windows PowerShell Pipeline
How the Pipeline Works
Using PSProviders and PSDrives
Querying System Information Using WMI and CIM
Working with Variables, Arrays, and Hash Tables
Basic Scripting
Advanced Scripting
Administering Remote Computers
Using Background Jobs and Scheduled Jobs
Using Advanced PowerShell Techniques and Profiles
Configure Windows PowerShell
Find and Run Basic Commands
Windows Administration
Use the Pipeline
Filtering Objects
Enumerating Objects
Sending Output to a File
Work with Pipeline Parameter Binding
Use PSProviders and PSDrives
Work with WMI and CIM
Working with Variables
Basic Scripting
Accepting Data from Users
Implementing Functions and Modules
Using Basic Remoting
Using PSSessions
Using Background Jobs and Scheduled Jobs
Practicing Advanced Techniques
Redeeming your Microsoft Software Assurance Training Vouchers:
This course comes with three months, 24x7 access to:
This course is available in the following formats:
Train at your own pace with 24/7 access to courses that help you acquire must-have technology skills.


text:
My Creative Space.
Totally different to my original idea of Satchel, totally inspired by the bag it replaces ... seen here behind. The paper version serves it purpose well but its getting a little ratty and is un necessarily deep.
I just have to work out the handle placement and attach them, my mind is ticking over with options so I just need to settle on one. LOL
I plan to use it to carry my knitting, I travel on busses a lot.
It also fits my current crochet project and reading material nicely too.
For what I am doing now its a perfect fit and it would also hold my embroidery floss cases and a small hoop nicely ... if ... when ... I start embroidery again.
Its soft sided in contrast to its boxy shape and that poses no inconvenience and perhaps works to an advantage as it folds over on itself when sitting in the cupboard at work or floor at home so my work isn't gathering dust.
I see a lot more bags in my future and a growing stash of stabiliser options too.
For more creative spaces pop over to Kirstys.
24 comments:
I rather like the fabric you have chosen for the bag. It is very summer. :)ReplyDelete
What a cute bag..Can't beat the functionality of it...I have yet to brave the transporation of my crochet projects. Maybe a bag like this would do the trick :PReplyDelete
Hey Tammy, your bag looks wonderful. It'll be such a great summer accesory. I am having computer issues, is there any way u could post my link into Kirsty's grid 4 me? Thanks heaps. XReplyDelete
I love it! So cheerful and enthusiastic :-) How can you not be inspired to work on whatever's inside with a bag like that!ReplyDelete
Perfect size for craft on the go.ReplyDelete
I love the bag! If I ever see it on the bus, I'll be sure to say hello to it's owner.ReplyDelete
oh tammy the colors are magic in your new bagsReplyDelete
Great work - bags are fun and useful) to make - so many options and designs. Have fun!ReplyDelete
oooh, I totally love it, great job!ReplyDelete
I love your new bag Tammy, colourful and happy. A lovely bag to put all of your creative work in.:)ReplyDelete
Just perfect........ I say! Bring on summer!!ReplyDelete
You can never have too many bags! Great colours.ReplyDelete
What wonderful bright and cheery fabric, I like the way the black contrasts with the colours. Super summer tote.ReplyDelete
Looks fabulous Tammy. 'Tis the season for swapping knitting for embroidery you know. Isn't it great to be able to use your transport (and any other waiting) time for creativity?! I'm infatuated with the idea of making bags but I've yet to dive in and try one. The colours on this one are fantastic - perfect for the cheery weather ahead. xxxReplyDelete
It wouldn't be possible to go past that bag and not feel like delving into it to create something - it is terrific. Peta (loving your knitting too)ReplyDelete
Lovely bag Tammy, I would love to go on a big bus ride with you, I will bring some crochet too and ask you questions about breadmaking...ReplyDelete
Have fun in your creative pursuits!
Annamaria :)
I like your bag, Tammy! It is so bright and colorful, plus it's the perfect size. Well done!ReplyDelete
fab fabric. What a great size for keeping all those essential crafty things whilst you're on the move :)ReplyDelete
How cool that your fancy bag was inspired by a paper bag. And that it is just what you need. Possibly the perfect bag!! If you can't decide on the handles, are two options possible???....ReplyDelete
What a fun, happy bag. I store my knitting in a bag too and I love the fact that I can pick it up and bring it along with me wherever I go.ReplyDelete
Really lovely fabric. I also like the fact it is soft instead of stiff, very practical as well as pretty.ReplyDelete
I love the colors in your bags. It's such happy fabric. Much prettier than the paper bag :)ReplyDelete
Great functional bag. i love the idea of having projects and reading material always at the ready.ReplyDelete
Love the bag! Just found it via your sewing machine post. :)ReplyDelete


text:
On Jan 20th 2017, 200+ protesters were mass-arrested, detained, and prosecuted.
For 18 months, these protesters stood up to the Trump Justice Department—and won.
Coming soon!
The story of the J20 Arrests and Prosecutions
For now, find us on Twitter (or your favorite social network):
The "J20" Arrests & Prosecutions
On Jan 20th, hundreds of inauguration protesters were mass-arrested, held in inhumane conditions, and are now facing at least 8 felony charges each. Their cell phones were confiscated and searched, their homes were raided, and their social media data was seized.
After an initial (already unusual) "felony rioting" indictment, prosecutors pushed for a series of revisions - pulling in more defendants and bringing each person's total charges to a staggering 8+ felonies.
Prosecutors in these cases have demanded vast troves of website data involving millions of unrelated people, sought gag orders forcing Facebook to silently hand over data without notifying users or allowing for legal due process, and 'cracked' over 100 defendant cell phones to extract terabytes of personal data.
At the same time, they requested a rare 'protective' order to keep defendants from sharing police body camera footage - shielding the police from public accountability, and complicating efforts to prepare a defense.
Prosecutors have even balked at their basic, legal duty to disclose individualized evidence - citing the workload of so many cases. The irony of that complaint, given the disruption caused in over 200 people's lives by their choice to bring these charges, appears lost on both the prosecution and the court.
Most defendants will wait more than a year for their day in court - under the constant, debilitating threat of decades in prison.
Throughout these cases, prosecutors have engaged in vindictive, intrusive, and excessive behavior - from detectives misleading the Grand Jury to offers of 'wired' pleas designed to coerce easy 'wins' for the prosecutor by pitting defendants against family and friends.
Even following complete defeat in the first trials—where the jury returned 'not-guilty' verdicts for all defendants and the judge dismissed some charges for lack of evidence—they refuse to drop the charges against the remaining defendants.
But who 'wins' when prosecutors abuse their power and disrupt lives?
If we let these cases continue uncontested, we empower one of the world's biggest school-yard bullies - the modern American prosecutor - to set aside even the meager protection offered by the Constitution.
We make the next abuse easier; the next target more vulnerable.
Fortunately, unlike so many of the complex problems we face, the power to end this lies squarely in the hands of a few specific people.
The US Attorney for DC has near-complete discretion to drop these charges!
It's up to you to demand that they do.


text:
Not directly related to the log entry, but several plugins (EventWatcher, SystemMonitor?) expose a CPU-load type of parameter.
In particular, EventWatcher has a CPU05 variable giving CPU loading over a 5-minute average.
If really necessary, you could pull this directly from the pseudo-file in /proc/loadavg, without even needing a plugin installed.
Edit: I should add that I routinely log memory usage (free and available) plus CPU load for all three of my Vera systems. See attachment


text:
exclusive! Antthony "Glitter" Asymmetric Top and Pant Set
- Item qualifies for VIP Easy Returns with the HSN Card. Restrictions apply. See Details
- ExtraFlex available when paying with the HSN Card. Select the FlexPay option above and then select ExtraFlex. Apply Now
HSN Credit Card Perks & Offers Apply online or call 1-800-695-1418.
Overview & Details
Tired of trying on different tops and bottoms until you find ones that seemingly go together? When you're done, you've got a pile of clothes on the bed that the dog is buried under. Get it right the first time with this perfectly matched set. The stylish, asymmetric top with classic, pull-on pants adds effortless elegance to your day-to-night looks.
What You Get
- Top
- Pant
Garment is sized by the bust and hip measurements. If your bust and hip correspond to 2 different sizes, choose the larger size from the HSN Size Chart.
|Color Choices:
|Almond, Black or Midnight Blue
|Stretch, matte jersey knit
Top Details
|Design Details:
|Asymmetric, mock layered seaming
|Asymmetric, sharkbite
Pants Details
|Full elastic
|Leg Type:
Size, Content & Care
|Size Choices:
|XS-XL; 1X-3X Average or Petite
|Body Length:
|Approx. 29-1/2"L (average); 27-1/2"L (petite)
|Approx. 30-1/2"L (average); 28-1/2"L (petite)
|Top Fit:
|Loose-Fitting: Designed for 4 to 6 inches of ease between body and garment. Measures 4" - 6" larger than the fit-critical body measurement. Generously sized for ease of movement and fabric drape
|Pant Fit:
|Semi-Fitted: Designed for 3 to 4 inches of ease between body and garment. Measures 3" - 4" larger than the fit-critical body measurement. Somewhat close to the body, but cut for ease of movement and fabric drape.
|95% polyester, 5% spandex
|Machine wash, line dry
|Country of Origin:
Love this pant set
This is so comfortable, so pretty, dress it up or down. Feels like you are in your pajamas all day! And very flattering.Highly recommend.BobbiL12, NJWas this review helpful? 0 out of 0 found this review helpful
Sent back--The Pants were much too long for being petitePHYLLY31, FLWas this review helpful? 5 out of 5 found this review helpful
Day or night
This was one of my frist item from Anthony, love love how it fitted my body. The color was true blue which i love This was a home run for me will buy more. 5 all the way home.pudding65, NVWas this review helpful? 3 out of 3 found this review helpful
Fit and style
I love the fit of this outfit. True to size with a little room. The shirt fits just right. I am shot and with a heel or a flat this fits just right. Very comfortable and soft.Niecy46, MOWas this review helpful? 2 out of 3 found this review helpful
Love ,love this suit
I love the almond color ,the feel and the coverage is on point . I love the feel of the fabric .thanks Anthony for another winner. Tons of compliments wore it too my birthday bash ,I was the belle of the ball.cleopatra57, CAWas this review helpful? 3 out of 4 found this review helpful
Antthony Design Originals
Designer Antthony has captured a distinctive, urban look in Georgette silk and other waif fabrics that easily tie, silhouette or drape. Free-flowing designs in floral, paisley and geometric patterns give you the comfort and style you deserve – perfect for fun, casual or dressy occasions. Exotic accents include sequins, beading, fringe, ruffles, crochet trim, tassels, lattice, burnout edging and embroidery, offering you a wardrobe unrivaled within your circle of friends. Coordinating shoes and a handbag work with several pieces to complete your head to toe look.
Remind me about Antthony Design Originals upcoming shows.
When To Watch
with Host Tina Jennings
with Host Tina Jennings


text:
- Research
- Open Access
Stabilizing mutation of CTNNB1/beta-catenin and protein accumulation analyzed in a large series of parathyroid tumors of Swedish patients
- Peyman Björklund1,
- Daniel Lindberg1,
- Göran Åkerström and
- Gunnar Westin1Email author
© Björklund et al; licensee BioMed Central Ltd. 2008
- Received: 26 February 2008
- Accepted: 09 June 2008
- Published: 09 June 2008
Aberrant accumulation of β-catenin plays an important role in a variety of human neoplasms. We recently reported accumulation of β-catenin in parathyroid adenomas from patients with primary hyperparathyroidism (pHPT). In CTNNB1 exon 3, we detected a stabilizing mutation (S37A) in 3 out of 20 analyzed adenomas. The aim of the present study was to determine the frequency and zygosity of mutations in CTNNB1 exon 3, and β-catenin accumulation in a large series of parathyroid adenomas of Swedish patients.
The mutation S37A (TCT > GCT) was detected by direct DNA sequencing of PCR fragments in 6 out of 104 sporadic parathyroid adenomas (5.8%). Taking our previous study into account, a total of 9 out of 124 (7.3%) adenomas displayed the same mutation. The mutations were homozygous by DNA sequencing, restriction enzyme cleavage, and gene copy number determination using the GeneChip 500 K Mapping Array Set. All tumors analyzed by immunohistochemistry, including those with mutation, displayed aberrant β-catenin accumulation. Western blotting revealed a slightly higher expression level of β-catenin and nonphosphorylated active β-catenin in tumors with mutation compared to those without. Presence of the mutation was not related to distinct clinical characteristics.
Aberrant accumulation of β-catenin is very common in parathyroid tumors, and is caused by stabilizing homozygous mutation in 7.3% of Swedish pHPT patients.
- Parathyroid Adenoma
- Parathyroid Tumor
- Swedish Patient
- CTNNB1 Mutation
- Rectal Carcinoid Tumor
Parathyroid disease with hypersecretion of parathyroid hormone and generally also hypercalcemia occurs in primary hyperparathyroidism (pHPT), due to growth regulatory disturbance in one or several parathyroid glands. Activation of CCND1 oncogene expression or inactivation of the MEN1 tumor suppressor gene contributes to deregulated growth control in a fraction of sporadic parathyroid adenomas [1–4].
Activation of the Wnt/β-catenin signaling pathway by aberrant accumulation of stabilized β-catenin is involved in the development of many neoplasms. β-catenin accumulation is typically caused by mutations in components of the signaling pathway, such as APC, Axin, β-Trcp, and WTX, or results from secondary events. In addition, protein stabilizing mutations in the glycogen synthase kinase 3β phosphorylation sites of β-catenin (Ser-33, Ser-37, Thr-41, Ser-45) occur with varying frequency in several neoplasms [5–9].
We recently reported activation of the Wnt/β-catenin signaling pathway by aberrant accumulation of β-catenin in parathyroid adenomas from patients with pHPT [10]. The accumulation of β-catenin was caused by expression of an aberrantly spliced internally truncated Wnt receptor LRP5 or by a stabilizing mutation (S37A) in CTNNB1 exon 3 [10, 11]. Stabilizing mutations of CTNNB1 have not been detected in parathyroid adenomas of patients from Japan and the United States [12, 13]. Here we have determined the frequency and zygosity of mutations in exon 3 of CTNNB1, and β-catenin expression status in a large series of parathyroid adenomas of Swedish patients.
Tissue Specimens
Sporadic parathyroid adenomas (n = 104) were acquired from 104 Swedish patients with pHPT diagnosed and operated on in the clinical routine at the Uppsala University Hospital. Normal parathyroid tissue was obtained as normal gland biopsies in patients subjected to parathyroidectomy. Tissues were intraoperatively snap frozen. Informed consent and approval of institutional ethical committee were obtained.
DNA Sequencing
DNA from parathyroid tumors was prepared by standard procedures including proteinase K treatment and phenol extraction. Blood DNA was prepared using the Wizard Genomic DNA Purification Kit (Promega Corp., Madison, WI). DNA was PCR amplified with primers for exon 3 of CTNNB1. PCR forward primer: 5'-TGA TGG AGT TGG ACA TGG CC; reverse: 5'-CTC ATA CAG GAC TTG GGA GG. The complementary strand was also sequenced for fragments with mutation. The PCR fragments were sequenced directly on the 3130xl Genetic Analyzer using the ABI Prism Dye Terminator Cycle Sequencing Ready Reaction kit (Applied Biosystems, Foster City, CA).
Restriction Enzyme Digestion
CTNNB1 exon 3 PCR fragments were purified using the GFX PCR DNA and Gel Band Purification Kit (GE Healthcare Europe GmbH, Uppsala, Sweden) and cleaved with Xma I or Nla III according to instructions by the manufacturer (New England Biolabs, Inc., Beverly, MA). Products were analyzed by agarose gel electrophoresis.
CTNNB1 Gene Copy Number
SNP genotyping
SNP position
refSNP ID
Patient 1
Patient 2
Patient 3
Patient 4
Immunohistochemistry and Western Blotting
Frozen tissue sections were stained as described [10] using an anti-β-catenin goat polyclonal antibody with an epitope mapping at the C-terminus (Santa Cruz Biotechnology, INC., Santa Cruz, CA; catalog no. sc-1496). Protein extracts for Western blotting were prepared [10] in Cytobuster Protein Extract Reagent (Novagen Inc., Madison, Wisconsin, USA) supplemented with Complete protease inhibitor cocktail (Roche Diagnostics GmbH, Penzberg, Germany). The anti-active (nonphosphorylated) β-catenin [14] mouse monoclonal antibody (Upstate, Lake Placid, USA, # 05-665), the anti-β-catenin goat polyclonal antibody (above), and anti-actin goat polyclonal antibody (Santa Cruz Biotechnology INC.) were used. After incubation with the appropriate secondary antibodies, bands were visualized using the enhanced chemiluminescence system (GE Healthcare Europe GmbH, Uppsala, Sweden). Membranes were scanned by the ChemiDoc XRS and the band intensities were determined using Quantity One Software (Bio-Rad Laboratories, Inc., Hercules, California, USA).
Statistical Analyses
Unpaired t test, z test, and χ2 test were used. The data were calculated with Statistica 6 (StatSoft, Tulsa, OK, USA). Values are presented as arithmetrical mean ± SEM.
Homozygous CTNNB1 Stabilizing Mutation S37A
In order to resolve the issue of zygosity for the S37A mutation, 4 tumor DNAs with the corresponding constitutional DNAs were genotyped with the GeneChip 500 K Mapping Array Set (Affymetrix). Gene copy number analysis was done by comparison of informative single-nucleotide polymorphisms (SNPs). Five informative SNPs in CTNNB1 and 2 SNPs downstream of the gene showed equal copy number for the 4 paired DNA samples (Table 1). Thus, taking also the DNA sequencing results into account the S37A mutation was homozygous in these 4 tumours, rather than hemizygous with one mutant and one deleted CTNNB1 allele.
β-catenin Protein Expression
We have found that a total of 9 out of 124 (7.3%) randomly selected parathyroid adenomas displayed the CTNNB1 stabilizing homozygous mutation S37A. None of these 9 tumors expressed the internally truncated LRP5 receptor [11] (data not shown), further emphasizing the previous observation that these events are mutually exclusive [11]. The mutated LRP5 receptor, with the central region deleted, is expressed in the majority of pHPT tumors and is required for accumulation of β-catenin and parathyroid tumor cell growth [11].
The S37A CTNNB1 mutation commonly occurs also in gastrointestinal carcinoid tumors where 26 out of 29 tumors with mutations harboured S37A [15]. The mutant protein shows resistance to ubiquination and proteosomal degradation, with a longer half-life than wild-type β-catenin. S37A β-catenin also shows an enhanced affinity for LEF1 and TCF4, its DNA-binding partners in transcriptional regulation [16–18]. Homozygous mutation as detected by direct DNA sequencing of CTNNB1 seems to be uncommon in other neoplasms, but have been described in a rectal carcinoid tumor and in colorectal cancer [15, 19]. To be conclusive regarding zygosity, direct DNA sequencing clearly requires low or no contamination of normal cell populations in the tumor sample. In colorectal cancer cells with inactivating APC hemizygous mutation or activating CTNNB1 heterozygous mutation, the total β-catenin signaling activity seemed dependent also on silencing of SFRP genes by promoter hypermethylation with consistent constitutive WNT signaling [20]. Whether combined activity of two mutant S37A CTNNB1 alleles suffices for benign parathyroid tumor growth or whether constitutive WNT signaling is required in addition, remain to be investigated.
DNA sequence analysis of 24 parathyroid adenomas from Japanese patients revealed no CTNNB1 mutations, and immunohistochemistry showed weak cytoplasmic β-catenin staining in 2 tumors [12]. In another study from Japan (n = 9), cytoplasmic and/or membranous β-catenin staining was seen in 8 adenomas and nuclear staining in one adenoma. DNA sequencing analysis was not done in these specimens [21]. Furthermore, a recent study did not detect CTNNB1 exon 3 mutations in 97 sporadic parathyroid adenomas from patients who had undergone parathyroidectomy in the United States. Unfortunately, β-catenin protein expression was not evaluated in this report [13]. Since we observed a CTNNB1 mutation frequency of 7.3% in adenomas from Swedish patients, this may suggest possible contribution of geographical origin (dietary or environmental differences, or different genetic backgrounds) to mechanisms of parathyroid disease. The CTNNB1 mutation frequency vary considerably also in colorectal cancer (1–60%) and melanomas (0.02–27%), apparently not related to geographical origin [8, 17, 22–30]. The observations may be attributed to the stochastic distribution of probability in analyzed material or to other causalities, like that the tumor sample purity and pathology must be guaranteed.
By analyzing a large series of tumors from Swedish patients, this study further emphasizes β-catenin accumulation as the most common aberration in parathyroid tumors of primary origin. CTNNB1-stabilizing mutations were found in 5.8% of the tumors, or in 7.3% when taking our previous study [10] into account. The WNT/β-catenin signaling pathway, with β-catenin and the internally truncated LRP5 receptor [11] in particular, present therapeutic targets for hyperparathyroidism.
This work was supported by the Swedish Research Council and Swedish Cancer Society. We thank the referee of another paper for suggesting the use of Xma I and Nla III. We are grateful to Birgitta Bondeson and Peter Lillhager for skilful technical assistance. We are also grateful to Marika Rönnholm at the Bioinformatics and Expression Analysis core facility at NOVUM, Karolinska Institute, Huddinge, Sweden.
Authors' Affiliations
- Marx S: Hyperparathyroid and hypoparathyroid disorders. N Engl J Med. 2000, 343: 1863-1875. 10.1056/NEJM200012213432508View ArticlePubMedGoogle Scholar
- Arnold A, Shattuck TM, Mallya SM, Krebs LJ, Costa J, Gallagher J, Wild Y, Saucier K: Molecular pathogenesis of primary hyperparathyroidism. J Bone Miner Res. 2002, 17 (Suppl 2): N30-36.PubMedGoogle Scholar
- Åkerström G, Hellman P: Primary hyperparathyroidism. Curr Opin Oncol. 2004, 16: 1-7. 10.1097/00001622-200401000-00002PubMedGoogle Scholar
- Åkerström G, Hellman P, Hessman O, Segersten U, Westin G: Parathyroid glands in calcium regulation and human disease. Ann N Y Acad Sci. 2005, 1040: 53-58. 10.1196/annals.1327.005View ArticlePubMedGoogle Scholar
- Polakis P: The oncogenic activation of β-catenin. Curr Opin Genet Dev. 1999, 9: 15-21. 10.1016/S0959-437X(99)80003-3View ArticlePubMedGoogle Scholar
- Lustig B, Behrens J: The Wnt signaling pathway and its role in tumor development. J Cancer Res Clin Oncol. 2003, 129: 199-221.PubMedGoogle Scholar
- Giles RH, van Es JH, Clevers H: Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta. 2003, 1653: 1-24.PubMedGoogle Scholar
- Polakis P: The many ways of Wnt in cancer. Curr Opin Genet Dev. 2007, 17: 45-51. 10.1016/j.gde.2006.12.007View ArticlePubMedGoogle Scholar
- Major MB, Camp ND, Berndt JD, Yi X, Goldenberg SJ, Hubbert C, Biechele TL, Gingras AC, Zheng N, Maccoss MJ, Angers S, Moon RT: Wilms tumor suppressor WTX negatively regulates WNT/β-catenin signaling. Science. 2007, 316: 1043-1046. 10.1126/science/1141515View ArticlePubMedGoogle Scholar
- Björklund P, Åkerström G, Westin G: Accumulation of nonphosphorylated β-catenin and c-myc in primary and uremic secondary hyperparathyroid tumors. J Clin Endocrinol Metab. 2007, 92: 338-344. 10.1210/jc.2006-1197View ArticlePubMedGoogle Scholar
- Björklund P, Åkerström G, Westin G: An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/β-catenin signaling. PLoS Med. 2007, 4 (11): e328- 10.1371/journal.pmed.0040328PubMed CentralView ArticlePubMedGoogle Scholar
- Ikeda S, Ishizaki Y, Shimizu Y, Fujimori M, Ojima Y, Okajima M, Sugino K, Asahara T: Immunohistochemistry of cyclin D1 and β-catenin, and mutational analysis of exon 3 of β-catenin gene in parathyroid tumors. Int J Oncol. 2002, 20: 463-466.PubMedGoogle Scholar
- Costa-Guda J, Arnold A: Absence of stabilizing mutations of β-catenin encoded by CTNNB1 exon 3 in a large series of sporadic parathyroid adenomas. J Clin Endocrinol Metab. 2007, 92: 1564-1566. 10.1210/jc.2006-2554View ArticlePubMedGoogle Scholar
- van Noort M, Meeldijk J, Zee van der R, Destree O, Clevers H: Wnt signaling controls the phosphorylation status of beta-catenin. J Biol Chem. 2002, 277: 17901-17905. 10.1074/jbc.M111635200View ArticlePubMedGoogle Scholar
- Fujimori M, Ikeda S, Shimizu Y, Okajima M, Asahara T: Accumulation of β-catenin protein and mutations in exon 3 of β-catenin gene in gastrointestinal carcinoid tumor. Cancer Res. 2001, 61: 6656-6659.PubMedGoogle Scholar
- Orford K, Crockett C, Jensen JP, Weissman AM, Byers SW: Serine phosphorylation-regulated ubiquitination and degradation of β-catenin. J Biol Chem. 1997, 272: 24735-24738. 10.1074/jbc.272.40.24735View ArticlePubMedGoogle Scholar
- Rubinfeld B, Robbins P, El-Gamil M, Albert I, Porfiri E, Polakis P: Stabilization of β-catenin by genetic defects in melanoma cell lines. Science. 1997, 275: 1790-1792. 10.1126/science.275.5307.1790View ArticlePubMedGoogle Scholar
- Williams BO, Barish GD, Klymkowsky MW, Varmus HE: A comparative evaluation of β-catenin and plakoglobin signaling activity. Oncogene. 2000, 19: 5720-5728. 10.1038/sj.onc.1203921View ArticlePubMedGoogle Scholar
- Ilyas M, Tomlinson IPM, Rowan A, Pignatelli M, Bodmer WF: β-Catenin mutations in cell lines established from human colorectal cancers. Proc Natl Acad Sci USA. 1997, 94: 10330-10334. 10.1073/pnas.94.19.10330PubMed CentralView ArticlePubMedGoogle Scholar
- Suzuki H, Watkins DN, Jair KW, Schuebel KE, Markowitz SD, Chen WD, Pretlow TP, Yang B, Akiyama Y, Van Engeland M, Toyota M, Tokino T, Hinoda Y, Imai K, Herman JG, Baylin SB: Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet. 2004, 36: 417-422. 10.1038/ng1330View ArticlePubMedGoogle Scholar
- Semba S, Kusumi R, Moriya T, Sasano H: Nuclear accumulation of β-catenin in human endocrine tumors: Association with Ki-67 (MIB-1) proliferative activity. Endocr Pathol. 2000, 11: 243-250. 10.1385/EP:11:3:243View ArticlePubMedGoogle Scholar
- Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, Kinzler KW: Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science. 1997, 275: 1787-1790. 10.1126/science.275.5307.1787View ArticlePubMedGoogle Scholar
- Sparks AB, Morin PJ, Vogelstein B, Kinzler KW: Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer. Cancer Res. 1998, 58: 1130-1134.PubMedGoogle Scholar
- Omholt K, Platz A, Ringborg U, Hansson J: Cytoplasmic and nuclear accumulation of beta-catenin is rarely caused by CTNNB1 exon 3 mutations in cutaneous malignant melanoma. Int J Cancer. 2001, 92: 839-842. 10.1002/ijc.1270View ArticlePubMedGoogle Scholar
- Reifenberger J, Knobbe CB, Wolter M, Blaschke B, Schulte KW, Pietsch T, Ruzicka T, Reifenberger G: Molecular genetic analysis of malignant melanomas for aberrations of the WNT signaling pathway genes CTNNB1, APC, ICAT and BTRC. Int J Cancer. 2002, 100: 549-556. 10.1002/ijc.10512View ArticlePubMedGoogle Scholar
- Pollock PM, Hayward N: Mutations in exon 3 of the beta-catenin gene are rare in melanoma cell lines. Melanoma Res. 2002, 12: 183-186. 10.1097/00008390-200204000-00013View ArticlePubMedGoogle Scholar
- Demunter A, Libbrecht L, Degreef H, De Wolf-Peeters C, Oord van den JJ: Loss of membranous expression of beta-catenin is associated with tumor progression in cutaneous melanoma and rarely caused by exon 3 mutations. Mod Pathol. 2002, 15: 454-461. 10.1038/modpathol.3880546View ArticlePubMedGoogle Scholar
- Johnson V, Volikos E, Halford SE, Eftekhar Sadat ET, Popat S, Talbot I, Truninger K, Martin J, Jass J, Houlston R, Atkin W, Tomlinson IPM, Silver ARJ: Exon 3 beta-catenin mutations are specifically associated with colorectal carcinomas in hereditary non-polyposis colorectal cancer syndrome. Gut. 2005, 54: 264-267. 10.1136/gut.2004.048132PubMed CentralView ArticlePubMedGoogle Scholar
- Luchtenborg M, Weijenberg MP, Wark PA, Saritas AM, Roemen GM, van Muijen GN, de Bruine AP, Brandt van den PA, de Goeij AF: Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study. BMC Cancer. 2005, 5: 160- 10.1186/1471-2407-5-160PubMed CentralView ArticlePubMedGoogle Scholar
- Thorstensen L, Lind GE, Lovig T, Diep CB, Meling GI, Rognum TO, Lothe RA: Genetic and epigenetic changes of components affecting the WNT pathway in colorectal carcinomas stratified by microsatellite instability. Neoplasia. 2005, 7: 99-108. 10.1593/neo.04448PubMed CentralView ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.