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Scrap Car Hutton Roof, LA6, Scrap your car for free
Scrap Car Hutton Roof are your Hutton Roof (LA6), Cumbria based free scrap car collection service. Having a car that is a non runner can be a real problem you will still be expected to keep the vehicle taxed if it is still on the road. You do not need to pay someone to scrap your car. We can take away your scrap car for free!
Breaking News in Hutton Roof
As well as offering a completely free collection, we are also currently able to offer cash for scrap cars in Hutton Roof depending upon the weight of the vehicle!
If you'd like us to make you an offer just ask when calling or add 'CASH QUOTE PLEASE' in the 'Additional Info' box when submitting our online form.
- DVLA notification
- Environment agency approved recycling facilities
- Completely free collection!
- Convenient collection times
- Nationwide coverage
Why not simply fill out the form to the right or ring a member of the team 0800 043 5100!
Choose Scrap Car Hutton Roof
We've got a large number of happy customers around Hutton Roof having traded there for many years now. We know the Hutton Roof area so well we can be with you in under 30 minutes. We are proud to be able to offer an unrivalled service and will arrive to collect your car at the agreed time slot. Our collection service is available at a time to suit your needs, we are open for business every single day of the year 24/7.
We will scrap your car in the most environmentally sound way in Cumbria. Dishonest scrap car collection companies may sell on your car as opposed to scrapping it, most of the time not even informing the DVLA of any change of ownership. This will leave you very vulnerable in the eyes of the law, and can easily result in you being fined a large sum of money. Scrap Car Hutton Roof always ensure that the DVLA are notified that your car has been scrapped, keeping your mind at ease. Whenever we scrap a car we always recycle or reuse whatever we can, meaning we are doing our bit for the environment.
Please try to ensure that your vehicle is disposed of correctly as we want to keep Cumbria clean and tidy. Broken down cars on streets makes our area very untidy and run down, scrap your old banger today and make your street and your neighbours happy. Scrap car collection, call the team!
How to scrap your car
We make it simple to scrap your car in Hutton Roof. Our phone operators are on hand to answer any of your questions. Otherwise, just take a look at our helpful guide to scrapping your car so that you know the procedure before calling.
Reasons to scrap your car
There are a lot of reasons you may want to scrap your car. One of the main reasons for scrapping a car will be that it has failed its MOT, and the work costs to much to put it right. If your car is ruined you might want to declare it off road but usually most people will scrap it.
The car scrappage scheme
The car scrappage scheme in Hutton Roof might seem like a great idea at first. However, you will be limited as to what you can get. You can't just go out and buy any car you want. This can cause people a lot of misery as you might have your heart set on a particular car only to be told that, "the vehicle is not in the scrappage scheme".
Just call us on 0800 043 5100 or fill out the following form:


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Tuesday, August 31, 2010
Responsible Riding
We are also responsible riders.
If you are a user of ATV's, skidoos, off-road bikes, and off road vehicles here in the Yukon please click on this link to fill out an opinion survey on the Safe Operation and Use of Off-road Vehicles.
Then go and become a member of the Yukon Off-Road Riders Association. Fill out their survey as well. You can also find them on facebook.
Both of these surveys will take just a few minutes of your time. The government needs to hear from responsible riders. Even if you only use your off-road vehicle a couple of times of year for hunting, to take photos, or a family ride in the snow please go and take this survey. Have your voice heard!
Just one more thing- please join our family in asking for a helmet law. We have seen tragedies that could have been easily prevented had a rider just been wearing a helmet.
Thursday, August 26, 2010
Off to Ross
I have my sewing bin all packed with three more pairs of mittens and a pair of booties on the go. A store here in town just sold two pairs of mittens and one pair of booties. Good timing since I just spent a bunch of money ordering new leather!
Have a good weekend everyone and thanks so much for the encouraging comments on my last post. I am blessed to have so much support.
Tuesday, August 24, 2010
And I thought summer would be easy...
Summer sucks ass. Veggies? Naw. How about hot dogs and marshmallows over the fire. Walks? Not in the +25 weather we had a lot of this summer and the hellish bugs. Sun to keep me energized? How about the sun to cook me so fast I have to hide in my basement.
I got off track. Really off track. Since March I have been losing the same 5lbs over and over again. I am mad at myself for wasting all of this time. The only thing that has kept me from going off the deep end has been Tina.
Tina, another awesome blogger who used to live in the NWT, is trying to lose some weight as well. We started a blog together to encourage each other. A goal was set of each of us losing 50lbs by Feb. 1st. What is on the line? A trip to Edmonton, thanks to my awesome husband, to finally meet Tina after years of talking online. Once a week we check in on this blog and share how we are doing. Without that this summer I know I would have done a whole hell of a lot worse.
I haven't talked much on my weight loss on the blog this summer probably because I have been hiding from everyone!! So time to come clean and tell everyone how lazy I have been. And I need the encouragement everyone was so generous with over the winter and spring. I feel odd asking for encouragement, but honestly it really helps me. And if that is what it takes, then I will ask for it.
Today was my check in day with Tina and I am going to share what I wrote on our blog here today too:
Last week I was doing great and then it all went to hell. Snacking went overboard, meal sizes were ridiculous, and then I got my period. Just call me camel this week. I weighed myself and it says 286.8. Fuck.
I am mad. Mad at myself for not staying on track. I did it for months last winter and my weight dropped easily. People keep saying oh don't worry, you are just at a plateau, but I know better. I am being lazy. I am not planning my meals ahead of time, I am not using my scale to measure my food, I am not keeping track of my calories, I am not walking every day.
So how do I get out of this funk? Same as I did last winter when I made up my mind to change my life. I write it all down. I make my charts, I keep track of calories, I plan my meals, and now I think of Tina kicking my ass if I don't hit my 50lbs and meet her in Edmonton.
This morning I ate my breakfast and after I write this I will put it all into my food planner online. I made Matt take the truck to work so I will have to walk to playgroup, even if it does rain which looks probable. I am going to print off my goal chart and put it on the fridge. I am going to make Matt take his granola bars to work so I don't snack on them. I am going to make my lunch before I leave the house this morning so I am not rushed when I come back after playgroup. I am going to plan my supper and take whatever it is I need out of the freezer. I am going to put my kitchen scale on the counter to remind myself to use it.
I am going to do it all.
Monday, August 23, 2010
Family Quadding Time
We took a very kid friendly trail to a tower above Little Salmon Lake. It is about 16km each way and the view at the top in unbelievable.
Our Date
We left our kids in the care of our friends and took off. Matt and I drove 100km up the North Canol road. It was so muddy that it took us three hours to get that far, and since the ferry goes back across the river at 5pm, we turned around at that point. Not a single caribou or moose came out to greet us and our guns. And I am officially re-naming that road as Chicken Road. Grouse everywhere and of course that season doesn't open for another week.
After that drive we weren't quite ready to head home. So we drove up to the Faro mine site, got the quads off the trailer and went riding for a few hours. I hadn't had the opportunity to explore up there at all since we moved to Faro, but I already cannot wait to go back! The sub-alpine terrain is gorgeous and the trails go on for miles. I just want to see over each hill!
After a few hours of quadding in drizzle and just above freezing temperatures we finally called it a day and went home. We arrived home right around 7:30pm fully expecting our kids to greet us at the door. But our friends worked their magic and both boys were sleeping when we walked in the door.
The only way that day could have gotten any better would have been us arriving home with a moose or caribou in the back of our truck. But I am not complaining!
Friday, August 20, 2010
Change of Plans
Instead of quadding, Matt and I are going to drive up the North Canol Road to look for either caribou or moose. Our freezers are nearly empty and need a refill before winter. Wish me luck; I haven't been out hunting since shooting caribou up in the Arctic nearly four years ago. And I shot that poor bugger in the rump- worst shot ever!!
My first caribou!
Kugluktuk, spring 2006
Like New!
Needless to say, they are no longer white. They are a nasty shade of off-white with highlights of purple (blueberries), blue (blue pen), brown (dirt, poo, chocolate cake), red (strawberries, red pen), orange (mac'n cheese) and a lot of unknown colours from who knows what!
On our trip south this summer I bought some vinyl fabric to re-cover the chairs and just got around to it last weekend. They look fabulous now! And the best part- I can now just wipe off any messes! Absolutely necessary for a house with two boys.
Wednesday, August 18, 2010
Backyard Progress!
The front yard has been dug up, walls built, dirt moved around.... There is still a lot to do, but I am starting to see what the finished product will be like.
The backyard has some dirt on top of the fill finally! We still need a heap more to get it deep enough so we can sod it next year. Matt has marked off the swing set area and will soon block it off with wood and fill the entire area with sand. The fire pit is in place and trees pruned back. The other big project for this level will be flower beds to go around the wall to make it look pretty and more importantly to keep the boys in!
A friend's husband made this awesome fire pit for us! How fantastic is this! I see many a night sitting around a warm fire with cold beer in my backyard over the years.
Went's Pit!
Tuesday, August 17, 2010
Etsy: Went North Creations
For anyone not familiar with Etsy, it is an easy to use and navigate website designed for handicrafters to sell their wares. A seller receives their own page and pays a very small fee to list their items for sale. Once items sell, you pay a small percentage back to the website. I have made one purchase from another seller and that too was an easy process.
So please check it out at http://www.etsy.com/shop/wentnorthcreations
There is a way on the site to request custom items, but I am still trying to figure that part out! Hopefully I have it set up soon.
Saturday, August 14, 2010
Damn he looks good!
He now weighs about the same as when I met him ten years ago.
You look fantastic Matt!
-taken Christmas 2009
-taken just two weeks ago, August 2010
He now weighs my goal weight. Uggg.... so far to go! Will be nice though to weight less than him one day.
Make sure to smack his ass and tell him how great he looks!
My Kid Free Day
Oh my.
It was so wonderful!
I spent almost the entire day hiding in my sewing lair. For the first time ever I was able to start and finish not just one, but two projects! I also took the time to teach myself how to use the walking foot for my sewing machine and to make some new patterns for ideas I have. Matt met me for a peaceful lunch at the restaurant and then it was right back to the lair to make a little bag. Then I made a delicious roasted chicken supper without kids underfoot.
A kid free day was exactly what I needed. I will definitely try to give myself a kid free day now once a month. But now in order to pay for it, I need to sell more of my handicrafts! I think I will be starting an Etsy account this fall to make it easier. Right now I have these lovely black leather and seal mittens for sale! They have rabbit trim and pile lining. They are a small fit, fitting a hand length of 6.5 inches (finger tip to bottom of palm. Leave a comment or email me if you are interested in this pair or would like something custom made to your size.
Thursday, August 12, 2010
Makin' Mukluks
But I wanted something new to try.
So this week I went through some patterns I had been given and tried the first one- a canvas top one with moose split on the bottom. The plan is to use my cheap hide for the process of perfecting the pattern and then shell out for the pricey stuff. But a fail. Wholy crud was it ever ugly. Not what I wanted at all. So then I pulled out the pattern a friend in Whitehorse gave me and wow! Perfect! I ended up recycling a beaver coat I had purchased and again using the moose split for the bottom. I think I did alright for my first try! The pattern is nearly the same as what I make my baby booties from.
Check them out:
I still have to make linings for them and ties for the top. I have no clue how to make yarn ties, so thank goodness for the internet. I am betting someone has a tutorial online to teach me how to do it.
Normally on the top of the foot that would be fur too, but I didn't have enough beaver to do it. I kinda like the look of the increased leather. Other more talent people would add beadwork, but even though I was taught how to bead when we lived in the NWT, I really don't like doing it. I have no talent for making pretty pictures out of beads.
For my first pair of fur mukluks, I am impressed with myself! Now readers- I need feedback on ways to make these better. Any suggestions? Or maybe you have a fantastic source of smoked moose hide that you want to share with me? Or idiot proof directions for making yarn ties? Please share!
And my friend in Whitehorse who gave me this pattern is going to send me her pattern for canvas mukluks. How lucky am I! Thanks Lena!
Healthy Pancake Fail and Recovery
He stared at them for a while (they had a nice orange brown colour), took one nibble and then said, "Mom, these pancakes are yucky for my tummy." He refused to eat anymore.
Meanwhile, Cavan ate two pancakes lickety-split and then screamed until we passed him Hunter's plate.
Whenever I make pancakes, I make enough that the boys can snack on them for the next day. This morning I gave Cavan one as a snack and Hunter requested one for himself. He stared at it, took a bite and then said in a surprised tone, "Mom, these aren't so bad after all!"
Silly kid.
Wednesday, August 11, 2010
By Myself?
Three days in three years. That sure isn't much.
I love being a mom, but the lack of me time has been a struggle, especially when we went to having two kids. Last fall and winter I was eating to cope with what I believe now was postpartum depression and I was exhausted all of the time. I thought then that my desire to have more me time was selfish, but I am now coming to realize that it isn't selfish- it is necessary!
My husband is fantastic with giving me a break when I need it. He does most of the bedtime routine with the kids and they spend a lot of time outside with him so I can clean or cook in peace. But that break is never more than an hour or maybe two- enough time to clean and maybe have a few minutes to return emails without a kid in my lap.
Last year a friend here in town started operating a dayhome and I began sending Hunter there once every couple of weeks. It gave me some quality time with just Cavan and I was able to get a lot of house work done while he played with Hunter's toys without fear of his big brother taking them away. I found it worth the money to have that break for a day. Plus I get receipts and can always claim that expense at tax time.
This Friday my friend has space to take two kids and I have been going back and forth on the idea of having an entire day to myself. One minute I am thinking things like why am I wasting money when I don't work, am I not a good enough mom to take care of my own kids, how horrible will Cavan be since he is so sucky for mom right now, maybe I should keep one kid at home and on and on. But then I start thinking that yes I need the break! I have a list of sewing ideas a mile long that I want to try, I want to go fishing without kids, I want to go berry picking without kids, I want to go quadding without kids... Now I know that is more than I can do in one day, but it still gets me excited about eight hours kid free.
Talking with Matt last night he told me I deserve the break. We have decided that once a week I will send one kid to the dayhome and once a month we will try to have both kids go for the day. And on these days I will not spend the entire day doing housework. I will spend time doing tasks I want to do such as sewing. It will cost me about $230 a month, but that isn't a bad price to pay for my sanity!
Monday, August 9, 2010
Vacation Part 3: Francis Lake
My parents camped with us and we spent a lot of time out in my father's boat. The fishing wasn't all that great, but I got a lot of relaxing time and Matt drank a lot of beer so we were happy! I even got to read three novels and start a fourth while I was there. Amazing how many books I go through when the internet is no where to be found!
The boys were dirty within minutes of waking up and by the end of the day I am pretty sure they were dirtier than the ground in our site. They had a blast playing with their grandparents, taking turns driving the boat, poking at fish, throwing rocks, swimming, driving their gator around he campground, picking up girlfriends from the site next door, eating treats from grandma and chasing the squirrels. The weather was around 30C everyday, but it still cooled off in the evenings making it nice for sleeping. This was the best vacation with family I have ever had! I hope we can do it again another summer for sure.
The bugs were nasty though!
Both kids were covered in bites and Hunter even had this one right at the top of his butt crack!
Relaxing with a gorgeous Yukon view!
Cavan driving the boat. The poor kid had so many bites on his face he looks as though he has chicken pox!
So one afternoon Hunter wanted to try swimming in the lake with his water wings. He wanted to catch up to his grandpa who was floating past at that moment. He stepped into the water and declared it too cold and ask me to carry him out deeper. So I did! Once I got about mid thigh he told me that was good and to let him swim out to catch the boat! So I obliged and dropped him into the cold lake! That kid clambered up me so fast I am not sure his swimsuit even got wet!! I had a good laugh, and he decided he would wait for the boat to come to shore to get him.
Matt caught a gorgeous trout!! Had it been just 1/4" longer we would have had to have thrown it back. Instead it was turned into fish burgers and is now in my freezer. Yum!

subset: commoncrawl


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Wow! Check out this "Before & After" by Creative Stylist, Kaleigh Harvey!
Thursday, September 24, 2015
Friday, September 18, 2015
Lipstick or Lipgloss?
Do you prefer lipstick or lipgloss? Either way, we've got your pout covered with an array of gorgeous shades from bareMinerals!
Tuesday, September 15, 2015
Transformation Tuesday!
It's Transformation Tuesday, and Creative Stylist, Kaleigh Harvey, is responsible for this gorgeous fall makeover!
Saturday, September 12, 2015
"Before & After" - Cute Bob!
Thursday, September 10, 2015
Balayage Before & After!
Creative Stylist, Kaleigh Harvey, used the balayage technique to highlight her client's virgin hair, and she loved the results!
Tuesday, September 8, 2015
Back-To-School Before & After!
This little lady came in to see Senior Stylist, Brittany Hilger, for a back-to-school cut. How cute is she?!
Friday, September 4, 2015
Before & After!
Tuesday, September 1, 2015
Transformation Tuesday!
What a gorgeous transformation from over-processed blonde to healthy, shiny hair by Creative Stylist, Kaleigh Harvey!
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Small Phones, Big Problem
These days you are hard pushed to avoid all the warnings we receive through the media about the state of the planet and the ways in which humans are harming it. Whether it be flooding in Pakistan, droughts in Australia or melting polar ice caps, there is always something in the news to remind us of the impact of global warming.
Indeed, some claim that even here in Britain we do not need to switch on the TV or open a newspaper to observe the destructive impact of industry on our environment, with weather conditions becoming less predictable.
There are many causes of such issues and it is important to bear in mind that no step towards reducing the destruction of our planet is too small. With this in mind, you might want to think about mobile phones.
Although each individual product of this nature is relatively small compared to many items that you can buy, when taken as a sum total across the globe, it is easy to see how they can contribute to problems for the environment in a big way.
Each year, millions of new handsets are manufactured to satisfy the demands of the market and this trend shows no sign of abating.
However, it is important not to despair at the thought of challenging the problem. By taking small steps such as engaging in phone recycling, you can help do your bit to reduce climate change.
And mobile phone recycling has never been easier, with firms such as us here at Mazuma Mobile ready to take your devices off you and deal with them in an eco-friendly way.
So don't just throw old mobile phones away, make sure you do the right thing.


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Congratulatory letter by the President of the World Council of Hellenes Abroad, Stefanos P. Tamvakis for the appointment of the new Minister of Foreign Affairs, Stavros Lambrinidis
The President of SAE, Mr. Stefanos Tamvakis, in his letter, expressed the satisfaction of the World Council of Hellenes abroad, on the appointment of Mr. Stavros Lambrinidis in his appointment in "the significant position of the Government, as Minister of Foreign Affairs, in one of the most critical times for our homeland".
"Personally and on behalf of the Board of the World Council of Hellenes Abroad I would like to express our sincere and cordial congratulations, wishing you every success in your work, beneficial and useful to our Homeland and Hellenism", stresses the President of SAE.
Mr. Tamvakis concluded stating "Your successful terms at the General Secretariat for Greeks abroad, in which we had a constructive and effective collaboration, at the European Parliament, as well as other positions you served, are a guarantee for the success in the task you are overtaking for the benefit of Greece and Hellenism. SAE is, and will always remain an active supporter of the Greek State and assist you in your work"
Source: ANA – MPA


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BUHS (BUHS) Class of 1951 Alumni List
Help us Update the BUHS 1951 Class List by adding any names missing from the list below:
Registered Alumni
1951 Class List
Know BUHS Class of 1951 graduates that are NOT on this List? Help us Update the 1951 Class List by adding missing names.
The most popular movie of 1951 was Quo Vadis? which has grossed over $30,000,000 since its release. The TV series Texaco Star Theater was the most popular show of 1951.
Reunions and Brawley Union High School News
More 1951 alumni from Brawley Union HS have posted profiles on Classmates.com®. Click here to register for free at Classmates.com® and view other 1951 alumni.
If you are trying to find people that graduated in '51 at Brawley Union HS in Brawley, CA, check the alumni list below that shows the class of 1951.
If you are an alumn of BUHS you should register now in the alumni directory. We also encourage you to interact with the rest of the alumni on this site. You can find old friends, share photos and stay updated on the latest school news.


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Born in Ste-Anne-des-Plaines, Quebec, Delisle starred in the QAAA with the Ste-Foy Governors. He then played in the QMJHL with Verdun College Francais and the Hull Olympiques. Montreal chose the feisty forward 86th overall in 1995 the returned him to junior where hit registered consecutive 30-goal seasons. As a pro, Delisle provided muscle and periodic offense on the AHL's Fredericton Canadiens and Quebec Citadelles while hoping to gain another opportunity to compete in the NHL.
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C.1. Primary…
C.1. Primary objectives
Standard text as first item of this section (as this sentence will be quoted word for word in point 2 of the Memorandum proper, it should be extremely concise): "The main objective of the Action is… (please add)â€
- The impact of COST comes from concrete outcomes, not just activity. Therefore indicate clearly what should be achieved through the Action.
The primary objective of the proposed Action is to produce a 'roadmap' or 'manual', conceived and endorsed by an international expert group of IT-researchers and researchers in the field of (digital) scholarly editing, visualizing and analyzing literary material. The 'roadmap' conceptualizes the development of a technical infrastructure for collaborative digital preparing, editing, publishing, analyzing and visualizing literary research materials.


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30% of Companies to Drop Health Coverage Because of Obamacare
One more example of We. Are. Finished. With. DC. -- unconstitutional federal health care law that companies are dropping their health care coverage for. Great, isn't it?
The Snooper Report
Join us as we Take Our Country Back
Sic vis pacem para bellum
Fight Accordingly


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Imagine a city covered in green. Tree canopies intermingle with the cityscape, wheat and other crops grow on the roofs, vertical gardens bring buildings to life, and streetscapes integrate with long linear gardens. These cities are not a current reality, but our Chicago office, along with OMNI Ecosystems, took a step towards imagining what that would look like in in the future.
On April 20th, the USGBC Illinois Chapter hosted the Chicago Thrives! Resilience Symposium, a collection of presentations by industry experts on resilience in Chicago. We presented findings from a mapping exercise conducted with OMNI Ecosystems' Molly Meyer (Founder and CEO) and Michael Skowlund (Dir of Landscape Architecture). The central question of our presentation was simple: what would happen if Chicago aggressively expanded its green roof program to as many buildings as possible? What would this do to the region's hydrology?
Chicago, like nearly every city in the United States, has a combined sewer system. This means that stormwater and sewage mix before going to a water treatment plant. In previous decades, these systems would fill beyond capacity during heavier rain events, and raw sewage mixed with storm water would be discharged directly into a local body of water. In recent years, cities have opted for tunnel or reservoir systems to act as large holding tanks for this overflow water. The overflow is then treated at a later date when the rain subsides. Chicago's Tunnel and Reservoir Plan or TARP does exactly this and is very effective at improving water quality in the region. However, it doesn't particularly address the issue of flooding on smaller, localized scales.
The region around Chicago was originally swamp land and often floods. Flooding, especially flash flooding, is a major issue for cities and home owners. It causes significant property damage, endangers motorists, creates environments for mosquito breeding (a major public health crisis), and causes erosion, among other problems. The primary culprit of urban flooding is impervious surfaces, materials that don't allow water to penetrate them and return to the water table. More simply put: most buildings and roads., If these surfaces are altered to become pervious, they will act as "tiny sponges" to hold water and slowly release it back into the atmosphere or soil or passively reach the water table.
OMNI develops, amongst many services, green roof media. These technologies allow roofs to grow small plants, crops, grasses, and even trees in some cases. Between the water consumption of these plants and the retention capacity of the media they are planted in, they can absorb a significant volume of water. For instance, a typical 1,500 square foot roof for a three story apartment building in Logan Square (neighborhood in Chicago) could absorb up to 2,400 gallons of water if retrofit with a 12-inch deep media green roof.
The Perkins+Will team from Chicago took OMNI's figures and processed the existing GIS data for Chicago for every building in Chicago that had viable data. Through a few statistical methods and some data analytics, the team reduced over 800,000 data points to 497,868 buildings with viable data and applied some calculations to determine a total building area that could host a green roof (see figure 2 for workflow). The high estimator used a slightly different statistical method than the low estimator, hence generating a different outcome of total square feet. Minimum saturation represents a media's performance when it is completely dry, while typical saturation looks at performance when the media has some moisture already present (see figure 3 for analysis, units are in gallons).
To add some context to these nebulous numbers, 1.8 billion gallons of water is the equivalent of 50 Willis Towers or 2,733 Olympic swimming pools. Alternatively, 1.8 billion gallons is about 20% of the total volume of TARP's current capacity. This figure is encouraging, because flood waters never reach TARP due to storm sewer backups or poor drainage on localized levels, ultimately creating more flood resistant communities. Furthermore, this translates to 6.7 – 9.8 million pounds of wheat flour.
It is estimated that the construction costs would range from $1.3 billion to $5.7 billion. This may sound prohibitively expensive. In 2014 alone, it is estimated that Cook County filed 181,000 flood claims, amounting to an estimated $733 million in damages. In only a few years' time, the roofs make up their outlay cost.
The potential doesn't stop at roofs. We want to investigate how roads and parks perform when we apply OMNI retrofits. Building rooftops only make up an estimated 13% of the total land area of Chicago (based on available GIS data). Using that same dataset, roads make up about 16% of land area in Chicago meaning that the remaining 71% is made up of parks, lawns, driveways, sidewalks, train tracks, vacant lots, and so forth. It's entirely possible for Chicago to better equip all of these spaces to become part of a living infrastructure network in the city. This would better serve communities by absorbing storm water, generating arable land, improving air quality, creating job opportunities, bettering public health, and enhancing urban aesthetics. Through actively stitching together multiple forms and layers of green infrastructure, large metropolitan cities could improve their environmental, fiscal, medical, and social resilience, ultimately improving the quality of life for urban dwellers.


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Details » Leah & Rob's Wedding
- Url: http://betrothed.informe.com/
- Category: Family & Parents
- Description: Photos of Our Special Day
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- Created On: Mar 31, 2008
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User Comments:
1. | Aug 3, 2014
sdWPc3 Enjoyed every bit of your article post. Cool.
2. | Jun 26, 2014
Let me just start this off saying I am a teen panert. My son is three and I have been dating his father for over seven years. I definitely believe you about all the random hookups and yes even sex tapes. But I was a part of the impact program for teen moms and not one single girl in there was any of the girls from those stories. They were very focused on their children and growing up. None of them pawned their kid(s) off on there panerts and they didn't get pregnant on purpose. Yes maybe a bad judgment call but they nor have I messed up our lives.
3. | Dec 16, 2013
Better blog Some habits are good for you and oetrhs are not. The same is true for your blog. Some of your blogging habits, meaning those things you do repeatedly, are good for you and your blog's growth and improvement while oetrhs are distractions that stop you
4. | Dec 14, 2013
Hey, Adam, don't you think the freshwater alrengs of SJ would be better served by the State eliminating the trout stocking and focusing instead on enhancing the habitat and numbers of those species more natural to the region, like bass, crappie, and pickeral? Trout (and trout stamps) don't fit in slow-moving, warmer blackwater, except that the State can make a few extra bucks by convincing spring and fall Saturday alrengs that they're really fishing with fly-rods and nymphs in the fast moving streamwaters of upstate New York.
5. | Dec 13, 2013
InnaFarrington:*girl*:Aleksander also not only the most charming,also he is the less-conflictю*Aleksander*:Many aristts make complainings that everything is not in the way they ordered.But in such a big show singers should adapt,not the organizers.For example we ordered a bright day' ,and they made a beutiful night [lightening].


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Who Says Real Estate Is Not Selling?
As of today, May 13, 2008, I have closed 22 properties with an additional 3 properties scheduled to close by the end of this month. While I have sold more in past years, my current sales numbers are more than 10 times the average real estate agent's sales. I think there are good reasons why this is true.
Sellers and Buyers who might have used their new, part-time or unproductive real estate agent relative, friend, church member, neighbor, etc. are choosing experience over friendship and family loyalty in this challenging market.
After 30 years as a full-time, successful REALTOR, I have learned to adapt to constantly shifting market conditions. We have systems in place to provide consistently exceptional service to our clients regardless of market conditions..
The current reality is that there are at least twice as many sellers than buyers so the job is to attract and capture buyers.
Studies show that buyers typically call more than one agent and continue calling until someone is available to talk to them. The first available agent often gets the sale.
My phone is answered 24 hours a day, 365 days a year by a live person. We have three licensed agents on our team to insure that someone is always available to talk to a buyer when they call. The office and the answering service transfers calls directly to one of us immediately. We prefer that instead of taking messages, we talk to people when they call.
The percentage of buyers who search for homes on the internet continues to soar. Our properties are listed on more than twenty individual websites and include multiple photos and visual tours, both of which increases the number of unique visitors who will stop to view your property online. To see how we market properties visit www.leslieedwards.com and www.SouthMetroAtlantaMLS.com
Contact me for a FREE Buyer and/or Seller Consultation by email, phone or in person.
leslie edwards sells real estate 770.460.9448
30 years experience is not expensive. It's priceless
RE/MAX Around Atlanta All Stars


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Lovely little beach houses! I love the pastel colors.ReplyDelete
These look so cute, I love to own oneReplyDelete
Thank you for linking up
Cute beach huts, I bet they are a lovely sight in any weather #MySundayPhotoReplyDelete
Ahh! So pretty! I love the colours xReplyDelete
I love beach huts and how colourful they can be. Makes a beach look a bit better and worth a visit. #mysundayphotoReplyDelete
Hi Afra, what pretty looking beach huts. I didn't realise there were any left.ReplyDelete


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The team at SailTime Newport Beach welcomes you to our webpage! We are here to assist in making your dreams of sailing a reality! Whether you're a potential owner member or member your dream of sailing is achievable at a fraction of the cost!
Please check out our local website for more information:
At SailTime Newport Beach our goal is to make sailing accessible, affordable and worry free, for you on a highly upgraded yacht.
SailTime provides access to the lifestyle that you and your family will love. Our fractional sailing program is the financially intelligent way to experience more of what the yachting life has to offer. Leave the hard work of boat maintenance to us and we'll leave the enjoyment of sailing to you.
Whether you enjoy a relaxing cruise in Dana Point, a weekend sail to Catalina, or pulling up for dinner at one of Newport's waterfront restaurants, SailTime is a great way to pursue your passion for life without all the hassles of boat ownership.
Send us an e-mail or call us and we'll show you how easy it is to become a SailTime member. We look forward to hearing from you!
Fair Winds,
Chris Jester Tom Collins
Managing Director Base Manager
714 878-7700 Mobile 562-964-6656 Mobile
email@example.com firstname.lastname@example.com
SailTime Orange County www.sailtimenewportbeach.com
1600 W. Coast Hwy., Suite E
Newport Beach, CA 92663


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Your company — whether you are a current employee or retired — may offer a benefit to you that can help multiply the impact of your philanthropy. Through corporate matching gift programs, some companies match a portion or all of your contribution to Penn Medicine. Your corporate human resources office can provide details on your company's program. Typically, your human resources office will furnish a matching gift form for you to include with your charitable contribution.
Find Matching Gift Program Participating Employers
Congratulations to the 478 Penn physicians listed below who were included in Philadelphia Magazine's Top Docs™ 2018.
Penn Medicine is one of the world's leading academic medical centers.
A clinical trial is a research study involving patient volunteers that are conducted to find safe and effective treatments for a variety of health conditions.


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- Recommendation ID
- Question
Older people in day and residential care:- How effective are interventions in day and residential care for older people that aim to prevent infection and to reduce antimicrobial resistance?
- Any explanatory notes
(if applicable)
Why this is important:- Day and residential care settings for older people are 2 settings where preventing the spread of infection and reducing the risk of antimicrobial resistance are particularly important. This is because many older people are vulnerable to infection as a result of chronic conditions, and there is the risk of infection spreading among large numbers of people. In addition, antimicrobial resistance is increasing in older people, particularly in relation to E. coli infections of the urinary tract.
Source guidance details
- Comes from guidance
- Antimicrobial stewardship: changing risk-related behaviours in the general population
- Number
- Date issued
- January 2017
Other details
|Is this a recommendation for the use of a technology only in the context of research?
|Is it a recommendation that suggests collection of data or the establishment of a register?
|Last Reviewed


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Bansai Cais Orange Candle Holder (set Of 3)
Take a stance for shapely style. Crafted of a glazed ceramic, this candle holder illuminates the appeal of simply striking design and contemporary flair.
Product Features
Product Features
- ,
- Made of ceramic ,
- Holds 3 pillar candles (not included) ,
- Clean with a soft, dry cloth ,
Depth: 12.5"
Length: 16.75"
Width: 14.5"


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Agnetha – My Very Best – Tracklist
Agnetha Fältskog – My Very Best is released in Sweden on 08 October, 2008 and can be pre-ordered at the site ginza.se for SwKr 159.00. Tracklist to follow.
Nice choice of cover, I must say – but there are presently no clues as to what period this compilation covers or on what label the release is on. Still, what with this single CD release and the 5CD Cupol compilation Original Album Classics due out September 29, Agnetha music fans/collectors certainly have two interesting products to look out for…
September 22/23, 2008 – Update: There are now, according to ginza.se, no less than four versions of the My Very Best CD for pre-order purchase, see screen sample below taken from their site. Although, in reality, it looks like possibly just two double CD items will make it to sale:
www.ginza.se screenshot as at 22 September, 2008
The distributor is given as SME and the record label as Columbia. The only version shown with a cover picture is the original jewelcase version as linked to below.
Translated from Swedish Sony/BMG press release:
Agnetha – My Very Best
On October 8 the career-wide collection album My Very Best by Agnetha Fältskog is released. It is SONY BMG, which together with Agnetha has made a record that reflects her career as a solo artist, from the tracks from her debut 40 years ago until the last album came out in 2004.
Among the 35 songs are her English-language version of SOS, När du tar mig i din famn (When you take me in your arms), Dröm är dröm, och saga saga, Wrap Your Arms Around Me, The Heat Is On, I Won't Let You Go, Let It Shine and also includes Agnetha's special favorite from the ABBA period, The Winner Takes It All. The accompanying booklet contains an introduction by Agnetha, unique images and all song lyrics.
Agnetha Fältskog's career is remarkable and she is one of Sweden's most successful artists of all time. ABBA has made all its members world-famous, including Agnetha with her special quality.
Agnetha has had a successful solo as a singer and songwriter. She has also produced many of her own recordings. Agnetha made the hit-list entrance for the first time in January 1968 when the debut single Jag var så kär entered 'Svensktoppen', the Swedish Charts. This was followed by five albums and a long list of well-known hits on the Swedish 'topplistorna'.
Her solo career continued in the 70s on the side of her involvement with ABBA. During the 80s Agnetha recorded three international solo album with the help of producer Mike Chapman, Eric Stewart and Peter Cetera. All were big sellers in Sweden and in other countries. In 2004 came the latest album My Colouring Book which went straight in at Number 1 on the Swedish music charts and acheived platinum selling status.
Agnetha – new album cover photo


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Scrap Car Oldways End, TA22, Scrap your car for free
We offer a reliable service for the collection of scrap vehicles in Oldways End (TA22), Devon. Your old scrap vehicle can cause you serious problems if you do not get them scrapped, for instance to keep your car on the road it will need to be taxed. You do not need to pay someone to scrap your car. We can collect your vehicle free of charge in Oldways End!
Recent News in Oldways End (TA22), Devon
As well as offering a completely free collection, we are also currently able to offer cash for scrap cars in Oldways End depending upon the weight of the vehicle!
If you'd like us to make you an offer just ask when calling or add 'CASH QUOTE PLEASE' in the 'Additional Info' box when submitting our online form.
- Nationwide coverage
- Completely free collection!
- DVLA notification
- Environment agency approved recycling facilities
- Convenient collection times
Why not complete the online booking form or ring for your free collection!
Choose Scrap Car Oldways End
After trading in Devon for over a decade we have built up our company based on very happy customers. We know the Oldways End area so well we can be with you in under 30 minutes. We set a time slot and we will not be late we have a reputation that is great for service and customer satisfaction. We will collect cars, vans and trucks day or night, seven days a week, and can work around you commitments.
We make sure that your car is disposed of the right way. Unreliable scrap car collection companies might sell on your car and try to make more money than if they recycled it, sometimes they will not even inform the DVLA of any change of ownership. This can result and usually does in you being fined. When we collect a scrap car in Oldways End we always ensure that the DVLA have been notified that the car is going to be scrapped, so that should keep your mind at rest. Here at Scrap Car Oldways End we make sure that we recycle everything, so as you can tell we always do our bit for the environment.
Make sure you do your bit for the local community and scrap your car in the correct way. Having old broken down cars littering the streets makes the area look very run down and untidy, so scrapping your car will make your neighbours happy. Get your car scrapped in Oldways End, call today!
The car scrappage scheme
The vehicle scrappage scheme may seem like a brilliant idea. However, you will be limited as to what you can get. You can't just go out and buy any car you want. This is frustrating for a lot of people as the cars in the scrappage scheme may not be to your liking.
Reasons to scrap your car
There will be many reasons for you to scrap your car. In our experience the most common reason of all is that the vehicle has failed its MOT and the required work to repair it is simply too expensive. If you have a scrap car that is unusable you need to either declare it off the road or scrap it, otherwise your will continue to need to pay road tax on the car.
How to scrap your car
You won't believe how easy it is to scrap your old car in Oldways End. Pick up the phone, dial our number and learn the process today. Otherwise please feel free to browse our website and find as much information as you can before you call.
Just call us on 0800 043 5100 or fill out the following form:


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Former President and Chief Executive Officer, Amylin Pharmaceuticals
Ginger L. Graham is the former President and Chief Executive Officer of Amylin Pharmaceuticals. Prior to this, Graham was Group Chairman, Office of the President for Guidant Corporation, a major cardiovascular medical device manufacturer. In addition, Graham serves on the Boards of Directors for Genomic Health Inc., Proteus Digital Health Pharmaceutical Division, Surefire Medical, Elcelyx Therapeutics, Clovis Oncology Inc. and the Circle of Life Hospice Foundation. She is a member of the Harvard Business School Health Industry Alumni Advisory Board, the University of Arkansas Chancellor's Campaign Steering Committee and the Advisory Board for the BioFrontiers Institute at the University of Colorado. She also serves on the Advisory Board for the Kellogg Center for Executive Women and co-chairs the Scientific Council of the University of Colorado's Center for Women's Health Research.


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Congress has its hands full keeping the Obama administration in check, and in most Americans' opinion, leaders could use some help — from the church. The key to confronting the President's agenda may be as simple as encouraging more pastors to speak out. So said 61% of Americans surveyed in FRC's latest poll — the results of which we announced yesterday at the National Religious Broadcasters Convention (NRB) in Nashville. With Christianity under attack as never before, the country is looking to its spiritual leaders to engage in the fight. As our First Freedom, religious liberty serves as the foundation for all other freedoms — which will all be at risk if it crumbles. If pastors would just speak to the issues from a redemptive heart, most people agree that we would see this country turn around.
Rafael Cruz, director of Purifying Ministries and father of U.S. Senator Ted Cruz (R-Texas) thinks that more boldness from the pulpit could have a profound effect on the state of our nation. At yesterday's news conference, he the press, "Too many pastors have been intimidated by a concept of separation of church and state not found in the Constitution." His comments were echoed by Dr. Robert Jeffress, senior pastor of First Baptist Church of Dallas, who insisted, "No president in history has launched an attack on religious liberty like President Obama. If pastors remain AWOL on this issue like they have on others, we will lose the war for religious freedom that our forefathers gave their life's blood to provide."
Marie Coppola February 2014


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This raw vegan coconut porridge is so delicious it's almost like a dessert!
It's packed with goodness and if you like a hearty breakfast look no further, it's very filling.
It serves 4 but it's so delish I frequently have it all in one go.
Hope you like it!
Raw Vegan Coconut and Apple Porridge
Serves 4
– 200 gram fresh coconut
– 2 apples
– 2 dates
– 1/4 cup cashew nuts
– 2 tablespoons sunflower seeds
– 1/2 tablespoon cacao nibs
– 1 teaspoon cinnamon
– 1/4 teaspoon vanilla extract
– nut milk to serve
MY YOUTUBE CHANNEL: http://www.youtube.com/lisagusto
FOLLOW ME ON INSTAGRAM @lisagusto
FOLLOW ME ON TWITTER: https://twitter.com/lisagusto


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It is a walk through 19th and 20th Century art movements at lightning speed with a series of very lovely (and to me) unknown single works - both paintings and and a smattering sculpture of most major artists one encounters in art history class. Several would be worth hanging on my wall and I wouldn't mind having to look at them every day. Others not so much, as you would expect - the Joan Miro and the Rene Magritte paintings, for example, were very disappointing choices.
All major art periods and schools are represented by their major artists, although not by their major work. The Auckland Art Gallery
Overall, "Degas to Dali" is less a curated/visionary exhibit than an educational effort. Since all works come from the National Gallery in Scotland some strange anomalies like the "Scottish Colourists" are included, the weakest section of the lot - although one of them, Sir William Nicholson "The Lustre Bowl" was one of my favourite pictures (so dark! so hard!):
Here are some of my other favourites:
Lucian Freud "Two Men Sleeping". An impressive rendering of the skin tones and textures.
Nicholas de Stael "Le Bateau". Lovely colouring and much darker than the photograph.
There were two Belgian surrealists in the collection, Rene Magritte with a dark, brooding war theme; and the ever hilariously funny Paul Delvaux (who usually forces any exhibit of his work to have an R18 rating) with - a particular obsession of mine (trams) - "La rue due Tramway".
My #2 top painting is Gustave Courbet "The Wave". Very Japanese-inspired but unmistakeably a north-west European scene.
My favourite is a tiny painting, done as a study, but it's full of atmosphere. The photograph doesn't do the piece any justice as the colours in the real picture are far warmer. Georges Seurat "Study for Une Baignade".
The exhibition runs until 10 June and a day pass costs $20.


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I had just returned home with family when it started raining and just a few minutes later we heard that there has been heavy rain and hailing in parts of the city. What I missed, to regret forever in the rest of life, was captured by others.
Here are some photos and a video clip of the snowy-makeover of my Lahore by mother nature on the evening of Saturday the 26th of February, 2011.
All photo credits to my son Abdullah's friend Umar.


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Google overnight sent out e-mails reminding users of its expiring App Inventor that it will no longer support the project on Dec. 31, 2011. As you'll recall, App Inventor was a tool that allowed anyone with arguably no programming skills to create Android apps, though it certainly wasn't quite as easy as that sounds. Google's shutting things down but open-sourcing the project to MIT, and you can migrate your projects over if you want to keep them. Head to App Inventor and hit the "Download all projects" button and you'll get a handy zip file.
Full text of the e-mail's after the break.
Dear App Inventor User,
As we announced on the App Inventor Announcement Forum, Google will end support for App Inventor on December 31, 2011, after which data in appinventorbeta.com will not be accessible and will be deleted from Google servers. You can preserve your App Inventor projects by simply clicking on the Download All Projects button on your My Projects page. This will download to your computer a zipped archive of all your projects. We recommend you retrieve your projects well before December 31st.
By the end of 2011 Google will also be making the complete App Inventor source code publicly available under an open source license, so that anyone can study the code and modify it as they desire.
In order to ensure the future success of App Inventor, Google has funded the establishment of a Center for Mobile Learning at the MIT Media Lab. Sometime in the first quarter of 2012, the Center plans to provide an App Inventor service for general public access, similar to the one Google is currently running.
In order for you to continue working with your projects in an open source instance (MIT or otherwise) of App Inventor you will need to download your data from appinventorbeta.com before December 31st and later upload them to an open source instance as it becomes available.
Please visit the App Inventor user forums to get future updates on App Inventor. You can also visit http://mobilelearning.
mit.edu/ for updates on what is being done with App Inventor at MIT.
The App Inventor Team


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TiE Tours for Schools
From 19th – 23rd October we'll be hosting some of the best TIE companies in the UK as they tour schools in Coventry and Warwickshire.
Designed specifically for young audiences, this work explores a range of ideas and issues and provides meaningful, cross-curricular learning opportunities.
For more information, or to make a booking for your school, please contact our Education Officer, Claire Procter, on 024 7684 6708 or email firstname.lastname@example.com.


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Heavy material losses were inflicted on Palestinian properties in the Jordan Valley due to the Israeli military drills over the past week.
The local activist Aref Daraghmeh affirmed that Israeli military drills inflicted heavy losses in dozens of agricultural lands in the Jordan Valley.
Over the past week, Israeli military vehicles have been deployed in large numbers throughout the Jordan Valley under the pretext of military drills.
Dozens of families were forcibly displaced during the drills period.
Heavy material losses are usually inflicted in such military drills in the area, where agricultural materials, sheds, and houses are partially or totally damaged.
(Source / 05.12.2016)


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Street Harassment - Hollaback London!/
Following on from my ranting on twitter about Eamonn Holmes using victim blaming language on This Morning (telling a rape victim that he hoped she would take taxis home from now on) I experienced some nasty street harassment.
I was at the bus stop at about 7pm, and noticed a man looking at me as he was on the phone. Now I sometimes do get looked at due to how I look, but it definitely felt a little more creepy than usual. However he walked away from the bus stop (looking back at me) so I didn't think much more about it.
He walked back towards me at the bus stop, and came close. I really thought he was about to snatch my phone, and my heart was racing. He whispered loudly 'I like your pussy'. But walked away. I was actually more relieved that i had my phone, but I was shaking.
I could see the bus finally coming, and I moved towards the curb. As I was about to board the bus, he came up behind me again, and whispered loudly at my, 'I want to fuck your pussy'. I boarded the bus, and checked he hadn't got on with me.
I was shaking but fuming with anger. Anyone who follows me on twitter would have seen my anger! How dare he make me scared like that?!
It reminded me of an awesome campaign - Hollaback
There is also Stop Street Harassment which is full of scary statistics like, ''In a 2008 study of 811 women conducted by Stop Street Harassment, almost 1 in 4 women had experienced street harassment by age 12 (7th grade) and nearly 90% by age 19.''
I have the right to walk down the street and feel safe. Street harassment limits women's peace of mind and freedom. It matters.


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- Research article
- Open Access
Dietary regulation of hypodermal polyploidization in C. elegans
- Luke S Tain1, 2Email author,
- Encarnación Lozano2, 3,
- Alberto G Sáez2, 3 and
- Armand M Leroi2Email author
© Tain et al; licensee BioMed Central Ltd. 2008
- Received: 08 August 2007
- Accepted: 12 March 2008
- Published: 12 March 2008
Dietary restriction (DR) results in increased longevity, reduced fecundity and reduced growth in many organisms. Though many studies have examined the effects of DR on longevity and fecundity, few have investigated the effects on growth.
Here we use Caenorhabditis elegans to determine the mechanisms that regulate growth under DR. We show that rather than a reduction in cell number, decreased growth in wild type C. elegans under DR is correlated with lower levels of hypodermal polyploidization. We also show that mutants lacking wild type sensory ciliated neurons are small, exhibit hypo-polyploidization and more importantly, when grown under DR, reduce their levels of endoreduplication to a lesser extent than wild type, suggesting that these neurons are required for the regulation of hypodermal polyploidization in response to DR. Similarly, we also show that the cGMP-dependent protein kinase EGL-4 and the SMA/MAB signalling pathway regulate polyploidization under DR.
We show C. elegans is capable of actively responding to food levels to regulate adult ploidy. We suggest this response is dependent on the SMA/MAB signalling pathway.
- Body Size
- Dietary Restriction
- High Food Level
- High Food Condition
- Wild Type Worm
Many animals change their life-history, size or shape in response to the environment; a phenomenon known as phenotypic plasticity [1, 2]. One environmental factor that exerts great influence over the development and life history of an organism is that of nutrition, or 'dietary restriction' [3–8]. Studies in a variety of taxa have shown that restricting the nutrition of juveniles or adults reduces growth and fecundity, while increasing longevity [9–11].
Over the last decade the underlying cellular mechanisms that regulate the effect of DR on growth have been explored more extensively [12]. In metazoans, it appears that much of an organism's ability to respond to DR is determined by insulin-like signalling. For example, overexpression of Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) is known to cause retardation of bone growth [13] and is found in DR rats at three times the normal level [14]. Drosophila and mice lacking components of the Insulin-like signalling pathway have greatly reduced body [15–19]. This reduction in size is due to a combination of reduced cell number and cell size [18, 19]. In contrast, insulin-associated pathways in C. elegans are known to determine fat storage, diapause, and longevity, but their effect on body size is less evident [20–25]. However, genetic mechanisms of body size determination in C. elegans are known to involve DBL-1 signalling (TGF-β ligand homologous to Drosophila's Dpp and vertebrate's BMP). DBL-1 regulates normal growth in C. elegans through the SMA/MAB pathway [26], along with downstream components such as LON-1 [27, 28]. It seems to us a reasonable hypothesis that the DBL-1 signalling may be involved in the DR response. Moreover, this relationship may extend to sensory-based regulation of growth. Mutant strains lacking properly formed and functional sensory ciliated neurons, such as the che mutants (cilia extension defects), together with downstream cGMP-dependent protein kinase EGL-4, exhibit alterations not only in longevity but also in body size [29–31].
In this study we investigate whether C. elegans undergoes a programmed regulation of growth in response to DR. First, we characterized life history responses, of wild type C. elegans, to DR, determining longevity, fecundity and body size. Second, we determined the role of the sensory system in growth regulation in response to DR. Thirdly, we examined the role of TGF-β signalling in DR mediated growth responses and determine how this relates to the sensory system.
Dietary restriction in C. elegansreduces body size, hypodermal ploidy and fecundity but increases longevity
The reduced fecundity and extended longevity are consistent with previous studies on DR using C. elegans grown in liquid media [5]. They are also consistent with Drosophila's experiments where DR induces adults of smaller size [34, 4]. However, unlike in Drosophila, where the reduction in size is due to a combination of reduced cell number and size, in C. elegans there is no alteration in cell number, at least in the hypodermis (Figure 1E), which secretes the cuticle, scales with body size and regulates it through TGF-β signalling [35]. Our data also show that the reduction in body size seen on DR is associated with reduced levels of hypodermal endoreduplication (Figure 1F), which we recently showed drives growth in adult worms [36].
Food consumption regulates body size but not hypodermal ploidy
Effect of Dietary Restriction on Body Size. All genotypes show significant (p < 0.0001), wild type-like (genotype by environment interaction term; p > 0.05), reductions in volume under DR.
Body size (mm3)
High Food
Low Food
% reduction
0.0051 (± 1 × 10-4)
0.0021 (± 1 × 10-4)
147, 121
0.0022 (± 1 × 10-4)
0.0009 (± 2 × 10-4)
106, 43
0.0029 (± 2 × 10-4)
0.0013 (± 8 × 10-5)
19, 12
0.0027 (± 1 × 10-4)
0.0012 (± 1 × 10-4)
41, 23
0.0021 (± 3 × 10-4)
0.0009 (± 5 × 10-5)
11, 16
0.0033 (± 2 × 10-4)
0.0013 (± 2 × 10-4)
26, 20
0.0063 (± 2 × 10-4)
0.0023 (± 1 × 10-4)
127, 118
0.0025 (± 1 × 10-4)
0.001 (± 6 × 10-5)
121, 80
0.0020 (± 4 × 10-4)
0.0010 (± 2 × 10-4)
19, 15
0.0025 (± 2 × 10-4)
0.0010 (± 1 × 10-4)
32, 24
0.0010 (± 1 × 10-4)
0.0006 (± 1 × 10-4)
33, 22
0.0019 (± 3 × 10-4)
0.0009 (± 2 × 10-4)
39, 22
0.0050 (± 6 × 10-4)
0.0017 (± 3 × 10-4)
20, 9
0.0019 (± 1 × 10-4)
0.0007 (± 4 × 10-5)
48, 35
0.0028 (± 3 × 10-4)
0.0020 (± 1 × 10-4)
0.0008 (± 4 × 10-5)
71, 56
0.0011 (± 1 × 10-4)
0.0005 (± 1 × 10-4)
85, 45
Effect of Dietary Restriction on Hypodermal Ploidy. All genotypes, unless stated (NS, p > 0.05), show highly significant (p < 0.0001) alterations from wild type ploidy responses to DR.
Hypodermal ploidy (xC)
High Food
Low Food
% reduction
10.9 (± 0.3)
8.4 (± 0.2)
113, 94
8.6 (± 0.3)
7.5 (± 0.4)
56, 25
8.4 (± 0.5)
7.5 (± 0.7)
17, 12
9.2 (± 0.3)
8.5 (± 0.5)
32, 21
8.4 (± 0.5)
7.5 (± 0.5)
13, 13
8.8 (± 0.4)
7.6 (± 0.5)
24, 17
12.3 (± 0.3)
11.6 (± 0.3)
101, 88
7.5 (± 0.5)
6.9 (± 0.4)
51, 32
7.6 (± 0.7)
7.0 (± 0.5)
14, 11
8.2 (± 0.4)
7.0 (± 0.4)
39, 23
7.4 (± 0.3)
6.4 (± 0.5)
35, 22
8.3 (± 0.3)
7.1 (± 0.3)
31, 18
12.2 (± 0.9)
8.5 (± 1.0)
9, 8
9.1 (± 0.5)
7.8 (± 0.5)
29, 18
8.9 (± 0.8)'
10.1 (± 0.7)
7.7 (± 0.4)
24, 17
8.5 (± 0.4)
7.0 (± 0.4)
43, 23
Endoreduplication requires the sensation of food by ciliated neurons
If the amount of food that a worm actually eats does not control endoreduplication, why do DR worms have low hypodermal ploidies? One possibility is that worms regulate endoreduplication in response to the amount of food that they sense in their environments. Worms sense their environment by means of their amphids, two small sensory organs that are exposed to the environment through pores located near the worm's mouth. Each amphid has 12 neurons from which eight project into the channel that leads to the pore [39–42]. These eight neurons are ciliated and have specialised endings containing receptor proteins that interpret and distinguish between external stimuli [43].
To test whether sensory signals from the amphids are involved in the DR response, we measured body size in various mutants possessing malformed, non-functional, sensory cilia. Consistent with Fujiwara et al. [30], we found that che-2(e1033) is smaller than wild type worms under high food conditions (Table 1). This phenotype is shared with all the other sensory cilia mutants examined (Table 1): che-13(e1805), osm-5(p813), che-3(e1124) and che-11(e1810). We also investigated whether the sensory mutants become smaller under DR and found that they had wild type responses (Table 1).
Then, to determine if the small body size of the sensory cilia mutants was associated with reduced ploidy we examined the hypodermis of all the sensory mutants. All of these mutants showed a reduction in ploidy (p < 0.001) (Table 2). More importantly, when subjected to DR, their ploidy declined only by approximately 11%, compared to a 23% reduction of the wild type (Table 2). We found no significant differences between the hypodermal nuclei number of che-2(e1033) and wild type worms (data not shown). These results suggest that signals from the amphids partly control endoreduplication in response to DR.
EGL-4 mediates the response from sensory cilia
Previous studies have shown that EGL-4, a cGMP-dependent protein kinase, functions downstream of sensory ciliated neurons in wild type worms [30]. Furthermore, mutations in egl-4 result in increased body length, altered sensory perception and egg laying behaviour, without affecting cilia structure [44]. To determine whether EGL-4 is required for the regulation of body size and endoreduplication in response to DR, we first characterized the growth of a strong loss-of-function mutant, egl-4 (n478), under normal levels of food. We found these worms to be 21% larger than wild type (Table 1) and possess a 13% higher level of hypodermal endoreduplication (Table 2), while maintaining wild type cell numbers (data not shown).
Surprisingly, under DR, egl-4 exhibits a wild type reduction in volume, but importantly, it fails to show a wild type reduction in endoreduplication. Hypodermal polyploidization, in egl-4 worms, declines only 5% under DR compared to a 25% decline in N2 (Table 2). Therefore, egl-4 defective worms maintain a hyper-endoreduplicated state at their hypodermis even under DR. Their hyper-endoreduplicated state, their failure to show wild type declines in endoreduplication, and the placement of EGL-4 downstream of CHE-2 [30] (also see Table 1 &2), all together suggest that EGL-4 acts as a negative regulator of food dependent endoreduplication.
DBL-1 signalling regulates the DR endoreduplication response
CHE-2 and DBL-1 act in the same pathway to regulate body size and hypodermal ploidy
In order to test the hypothesis that sensory signals and DBL-1 signalling act in the same pathway, we generated double che-2;dbl-1 mutants and analysed their size and ploidy levels under standard and DR conditions. When grown in high food conditions, che-2;dbl-1 was similar in size and ploidy (p > 0.05 for all comparisons), to dbl-1, che-2, or related genes (e.g. sma-6, che-13; Tables 1 and 2). The corresponding reduction for both characters under DR was also similar (Tables 1 and 2). This result suggests that dbl-1 and the amphid mutants act in the same pathway when controlling body size and hypodermal endoreduplication.
We also asked whether the regulation of body size by food intake per se was affected by DBL-1 signalling. To test this we examined eat-2;dbl-1 double mutants. We found that at high food levels, these worms are smaller than either eat-2 or dbl-1 (Table 1). This additive effect suggests that these genes regulate body size through different pathways, and is consistent with the finding that eat-2 worms have normal ploidy.
EGL-4 negatively regulates DBL-1
To confirm the effect of EGL-4 on the signalling of DBL-1 seen previously [30, 31], epistasis analysis was carried out between null mutants dbl-1 and egl-4. The nature of these mutants allowed a relatively simple analysis because egl-4 worms are larger than wild type, whereas dbl-1 worms are smaller [45, 46] (Table 1). The same thing can be said about hypodermal ploidy (Table 2). Examination of egl-4;dbl-1 worms revealed that, though slightly smaller, the double mutant did not significantly differ from dbl-1 worms in either adult volume or hypodermal ploidy (P > 0.05, for body size and ploidy; Tables 1 and 2, respectively), but it did with respect to egl-4 worms (P < 0.0001, for body size and ploidy).
Growth is a fundamental part of biology, yet its regulation is still poorly understood [12]. The notion that growth responds passively to nutrient availability has been replaced with the idea that growth is actively regulated in response to constant monitoring of nutrient availability in the external environment. We observed that when C. elegans is exposed to a low food environment there is a reduction in adult body size, similar to the reductions seen in other organisms e.g. Drosophila and Daphnia [4, 34, 49, 50]. However, in contrast to these organisms, the stunting in C. elegans is not due to a lack of cell proliferation, which implies that it is due to a reduction in cell size.
In order to investigate how DR controls adult body size in C. elegans, we studied the growth of wild type and mutant worms subjected to high and low food regimes. We found that all of our mutants became smaller by about the same amount (60%) at low food levels. This absence of interaction between food and genotype on growth might mean that none of the genes examined are involved in the dietary-dependent regulation of growth, but it could also simply mean that severe DR has additional effects.
For this reason we needed a more subtle way of examining the effects of DR on worm development. We have previously shown that hypodermal endoreduplication is required for growth in adult C. elegans [36]. Strikingly, we also found that DR inhibits hypodermal endoreduplication and so adult ploidy. This result gave us a sensitive assay for the effects of DR on the worm's development. We found that mutations in several genes mimic the DR response: even at high food levels, mutations that disrupt sensory or DBL-1 signalling show reduced ploidy and body size. That suggested to us that these genes might be involved in the DR endoreuplication response. This inference was confirmed when we examined these mutants under DR: in each case, the reduction in ploidy normally found at low food levels was largely abrogated. An even more striking lack of response to DR was also found in a large mutant that disrupts egl-4, a cGMP-dependent protein kinase previously associated with food sensing and food dependent behaviour [30].
These results, and our epistasis experiments, suggest a model in which the amphids monitor nutrient availability and activate a downstream signalling pathway involving the growth repressor EGL-4 (Figure 2). This kinase in turn regulates the DBL-1/SMA/MAB pathway, which positively regulates hypodermal endoreduplication. As the observed body size reduction under DR for both the sensory and DBL-1 signalling pathway mutants was similar to that of wild type (Table 1), we suggest that the main effects of DR on body size do not arise from the lack of endoreduplication, but rather from some other unknown pathway. A likely candidate could be what we call the "caloric pathway" in Figure 2. That is, the severe food restriction under DR could be masking the "sensory pathway" on body size when this one is impaired (e.g. in dbl-1(nk3); Figure 2). Reduction in food may prevent DBL-1 like mutants, whose endoreduplication levels do not drop as much as wild type under DR, from growing larger. Nevertheless, the reduced ploidy programmed by the sensing of lower levels of food (Table 2) must contribute to the stunting, since previous work shows a cause-and-effect relationship between endoreduplication and adult growth [36]. Consistent with our model, we showed that eat-2 mutants, one of the genes active in the feeding mechanism, has small size but normal ploidy, and that it reduces both characters in a wild type manner under DR (Tables 1 and 2). Recent work suggests that eat mutants have small body sizes due to increased autophagy [38], which is also included in our model (Figure 2).
How do our results relate to other animal models? Endoreduplication in Drosophila depends on a mitogen from the fat body that is regulated in a nutrition-dependent manner [51], which may suggest at least an underlying common plan beyond their differences (see Introduction)[52]. However, one of the proteins studied here, EGL-4, is a key regulator of nutrient responses not only in worms but, with the generic name of cGMP-dependent protein kinase, in organisms such as honeybees and fruit-flies controlling their foraging behaviour [53]. It is somewhat surprising that loss-of-function egl-4 has a change in hypodermal endoreduplication in high vs. low food which is half of what it is observed for the sensory ciliated or for the dbl-1-related mutants (Table 2). We think that this difference can be explained because egl-4's role in nutrient-dependent growth may be central, not shared with other proteins in parallel positions, whereas the various sensor genes investigated may be acting in parallel, either among themselves, or in relation to other genes or pathways (similarly for DBL-1 and the SMA/MAB pathway). In agreement with this, egl-4 is considered a highly pleiotropic gene, a main regulatory hub, not only mediating body size but longevity, locomotion feeding, and other processes [54].
Apart from the wild type strain N2, the following mutant strains were used, which were obtained from the Caenorhabditis elegans Genetics Center. Mutations are listed by linkage group: LGI: che-3(e1124), che-13(e1805); LGII: sma-6(wk7), eat-2(ad465); LGIII: lon-1(e185), sma-2(e502), sma-3(wk20), sma-4(e729); LGIV: egl-4(n478); LGV: che-11(e1810), dbl-1(nk3); LGX: che-2(e1033), osm-5(p813). We also used double mutants that we produced through crosses of the previous strains. Double mutants eat-2(ad465);dbl-1(nk3) were confirmed by PCR and sequencing using the following primers: 5'-eat-2: 5' TGATCACCCTAGTTGTCTGG; 3'-eat-2: 5' AGTGTAGAGGTACTGTATGG; 5'-dbl-1: 5' CATGGACAAACATCGGGGA; and 3'-dbl-1: 5' CGTGTACACAAATCTGTTCG. che-2(e1033);dbl-1(nk3) was generated by crossing heterozygous dbl-1(nk3) males with che-2(e1033) hermaphrodites. Then, their F1 progeny was PCR-screened for the nk3 allele, and double mutants in F2 were confirmed by PCR for both nk3 and e1033 alleles, and by DNA sequencing with oligonucleotides 5'- dbl-1, 3'- dbl-1, 5'-che-2: 5' AGATGGATGTTTACTGCC, and 3'-che-2: 5' GAGAATGACACAATGTGG.
All strains and experiments were maintained at 20°C.
Dietary restriction
We developed a novel method of dietary restriction (DR) on solid media. Three different food treatments are described within this study: excess, high, and low food treatment plates. Excess food plates: 100 μl of 5.19 × 108/ml E. coli (OP50)-Luria broth was spread around the centre of 5.5 cm NGM plates and left at room temperature for 24 hours before being killed by exposure to UV light for 1 hour. High food plates were prepared as excess food plates, but were exposed to UV light for 1 hour immediately after preparation. Low food plates were prepared as high food plates, but using a suspension of 3.95 × 107/ml E. coli (OP50)-Luria broth. For each experiment, the same E. coli culture was used for each food treatment. Treatment plates were replaced every 24 h during worm growth experiments to prevent depletion food source.
Body size analysis
Growth curves were determined for each strain, from worms grown individually on 5 cm Petri dishes. At 24 h intervals from 36 h to 120 h post hatching, images were captured using a video camera (JVC KY-F50) attached to a dissecting microscope (×50), and analyzed with OBJECT-IMAGE 1.62. Length and area were measured from pictures of individual worms and calibrated from a 1 mm graticule. Volume was calculated assuming cylindrical body shape using the formula (pi*length*(area/length)2/4) [36, 46]. All comparisons of body size use Log-transformed data.
Hypodermal ploidy analysis
Upon completing growth (120 h), worms were fixed in Carnoy's solution for 24 h, stained in a 0.007 mg/ml solution of 4',6-diamidino-2-phenylindole dihydrochloride (DAPI) [36, 48, 55, 56] and viewed under a Leitz epifluorescence microscope. Images of hypodermal and ventral cord nuclei were collected using a CV-M300 video camera, and analyzed using OBJECT-IMAGE 1.62. C values of hypodermal nuclei were estimated by dividing their DAPI-based densitometric quantifications by an average of those values from ventral cord nuclei (divided by two) in the same microscopic preparations [36].
Cell number analysis
Young adult worms were anesthetized with 0.1 M sodium azide [57], and viewed at ×1000 under differential interference contrast optics with a Nikon Eclipse E600 microscope. All nuclei, excluding neuronal and seam cells, between the posterior pharyngeal bulb and anus were counted. Images were captured with a CV-M300 camera and reconstructed by using Adobe PHOTOSHOP 4.0.
Longevity analysis
We analysed Kaplan-Meier survival distributions, which are based on a discrete stepped survival curve, adding time specific data as each death occurs. Individuals that died from internal hatching of eggs (bagging), or crawled off the plate were censored. Censoring allows the inclusion of individuals that were lost to the study, and thus contribute towards knowledge of survivorship, but nothing to the knowledge of age at death. Log-rank tests were performed to determine if survival curves were significantly different from each other.
Egg-laying assays
Individual worms were placed OP50-seeded 5.5 cm NGM plates before adult moult occurred and transferred to a fresh plate every 24 h. Total fecundity was measured with only fertilized eggs and larvae being included in the count.
Statistical analyses
Data analysis was undertaken using JMP 3.2 (SAS Institute, Cary NC, USA). Body size and ploidy data were compared across food level and genotype using a standard two-way ANOVA, including a genotype by environment interaction term, to determine responses of each genotype to DR. A food level by genotype interaction term allowed the comparison of each mutant genotype's response to DR to that of wild type. Ratios, between high and low food groups, were not used in this analysis.
We thank the Caenorhabditis Genetics Center for providing strains, and Almudena de Vivero for helping us to measure some of the mutants and their levels of endoreduplication. Our support came primarily from NERC (UK) and BBSRC. LST was also supported by Parkinson's Diease Society (PDS). EL and AGS were also supported by programs I3P and Ramón y Cajal, respectively, and by Plan Nacional I+D (CGL2005-00307; all from the Ministry of Education and Science, Spain).
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Tuesday, September 30
St. Jerome - "The Scorpion"
Domenico Ghirlandaio, St. Jerome in His Study, 1480. A handsome Renaissance work, that, while filled with the era's distinct classical style, nonetheless retains in this instance the rich iconographic detail of earlier medieval works (though his lion appears to have gone missing in this instance). Formerly on the ponte or roodscreen of the church of the Ognissanti, Florence, it was balanced on the other side by a fresco of St. Augustine. (At least so I have been told). The two are now housed in separate chapels within the church. The scissors are a symbol of biblical exegesis. And yes, we know they did not have cardinals back then. We do not care. They had bishops and they had popes, and that's close enough for me.
Long before I rode the water-taxi to Regla, many wise men and women had already discerned how best to approach such luck. One of these sages was Saint Jerome, the man who translated the Bible from Hebrew and Greek into Latin in the fifth century. Legend had it Saint Jerome used to say, "Have mercy on me, Lord, I am a Dalmatian," [the saint was from Istria in Dalmatia] while he beat his breast with a stone, struggling to suppress his own will and make his soul ready for God's grace. What a wise man. He knew how deeply sin dwells in our own skin. My own worst instincts still lead me to turquoise water, tangerine sunsets, and the judge's seat. I, too, find myself clutching jagged chunks of granite, beating my breast, seeking redemption. But I have to make a slight alteration in Jerome's prayer--a small change that makes a world of difference:
Misere mei, Domine, Cubanus sum.
"Have mercy on me, O Lord, I am a Cuban."
"I like Jerome because he is proof that even grumpy old men can become saints and get into heaven. Apparently, there is room for all temperaments in God's kingdom. [...] In Rome he had a benefactor who later became his best friend, a woman named Paula. She followed him to Bethlehem, and financed his monastery and three convents. When she died, crusty, cantankerous old Jerome was said to be inconsolable." (Source).
And for the kiddies on this feast-day, some juvenile POD just for the occasion. (Source.)


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The Premier Modular GearBox offers versatile and accessible storage for a variety of gear. A shelf with a cushioned liner, riding on full-extension ball bearings, slides for smooth operation. This storage cabinet docks efficiently under a Gladiator Modular Workbench or can stand alone as an additional work surface or tool stand.


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How do you circumvent the same, boring fate as your famous monster parents? Run away from home and launch a maniacal computer virus that might possibly annihilate human- and monster-kind. Oops.
Seventeen-year-old Boy's name is mundane, but his life isn't. With his celebrity parents (Frankenstein's monster and the Bride of), he lives among a merry band of monsters and mythical creatures in catacombs beneath Times Square. Under the guise of a theater troupe, they perform a popular creature-feature show, their human audience blissfully unaware that the stage is populated by bona fide trolls, sirens and an egomaniacal gorgon. With their mostly scientific origins, Boy and his parents aren't fully accepted by the 100-percent myth-and-magic creatures in their commune. So rather than endure segregation—and the life his parents planned for him—Boy runs away. Tech-savvy Boy's plan to leave his stamp on the world backfires when the computer virus he engineers goes rogue, the troll he loves goes feral and returning home means facing parental wrath. From naiad to minotaur, the straight characters, gay characters, jerks, bitches, buddies and one major diva are fleshed out, not merely relying upon their exteriors for interest. And as Boy's journey takes him from the tri-state area to the West Coast, each locale rings with well-researched authenticity.
A comically creepy coming-of-age road trip stitched together with action, romance, sex, combat and a couple of bootleg cocktails. (Science fiction. 12 & up)


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With $3.541 Billion in total sales volume, and 15,190 total transactions in 2018, First Weber is consistently the #1 most productive real estate firm in Wisconsin.
PLEASE NOTE: Market conditions can change rapidly across the state. Contact Chris McPhetridge for the latest updates.
Expect Less Focus On Organic, Farmhouse Design Elements And More Materials Like Concrete And Metal Accented With Rustic Touches
THE IDEA IS…to pair rustic elements like barn doors with modern materials like glass or metal.
With the boom in home prices in the recovery, homeowners have been profiting in the tens of thousands when they unload; and in 2018, the payout was at a peak. In the past year, the average homeowner pocketed $61,000 at resale, $11,000 more than what the average homeowner profited in 2017, and $21,500 more than the average realized in 2016, according to ATTOM Data Solutions findings.
The gains were an average 32.6 percent return. Gains haven't been this high since 2006, before the downturn.
Nationally, the highest profits were in the West, where home prices have risen substantially. While 2018 was the most profitable time to sell a home in more than 12 years, those along the coasts reaped the most gains.
"The effects of last year's tax cuts are wearing off as limits on homeowner tax deductions are in place and mortgage rates are ticking up ever so slowly, which could dampen the potential for home price gains in 2019," Todd Teta, chief product officer at ATTOM Data Solutions explains.
Chris McPhetridge, First Weber Realtors, 601 Oregon Street, Suite B, Oshkosh, WI 54902
The material in this publication is provided for your informational purpose only and is not intended to substitute professional advice.
Not intended to solicit presently listed properties. All information deemed reliable but not guaranteed.
© 2019 First Weber, Inc.. All rights reserved.