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April 2012 – Literature review of a cantaloupe melon concentrate naturally rich in superoxide dismutase/wheat gliadin biopolymer (glisodin) and its beneficial health aspects.
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The purpose of this technical publication is to review and update the science and health benefits reported to date for the superoxide dismutase enzyme naturally present in a cantaloupe melon concentrate and delivered in combination with wheat gliadin known as Glisodin.
Superoxide dismutase (SOD) constitutes part of the body's front line in antioxidant defenses, helping to maintain the physiological oxidant-antioxidant balance. However, this balance can be disturbed by a number of different factors, including aging, smoking, pollution, exposure to sunlight, infection and the subsequent immune response, and high intensity exercise. Under such conditions the body experiences oxidative stress and this is linked with increased risk of chronic disease.
In the past, oral supplementation with the superoxide dismutase enzyme in order to boost the body's antioxidant defenses has been ineffective. This is due to the biochemical conditions experienced in the gastrointestinal tract, leading to degradation of the enzyme and subsequently rendering it useless. This technical publication reviews the science related to Glisodin, a trade name for SOD-rich cantaloupe melon combined with wheat gliadin. Science is presented to demonstrate that combination with gliadin protects the SOD during passage through the stomach and enhances absorption once inside the intestine.
An extensive section is dedicated to the proof of this concept, with presentation of results from in vitro, in vivo and human studies which show both the increase in antioxidant status as well as the reduction of markers of oxidative stress. It will also be shown that Glisodin's bioactivity in humans has been demonstrated with a daily dose of as little as 250 mg over a period of just 14 days.
Anti-inflammatory and immune system modulating effects for the SOD-gliadin combination have also been reported, and these are discussed in this publication, with particular attention paid to the mechanism(s) behind the effects.
Reducing the production of reactive oxygen species associated with oxidative stress has many important health implications. These benefits include improved recovery after strenuous exercise, reduction of inflammation (reddening) in the skin on exposure to sunlight (UV radiation), improvement in heart health, and complications arising from diabetes. Sections in the review are dedicated to each of these areas.
This publication is presented in such a way as to be accessible to both scientists and non-scientists, with the intention of providing a concise and accurate review of the science behind the Glisodin ingredient. Key references are presented throughout the review.
Production of reactive oxygen species (ROS) is a normal process in oxygen-breathing organisms. Under normal physiological conditions a balance between these species and the body's anti-oxidant defenses exists. (Figure 1) However, certain conditions, like smoking, pollution, exposure to sunlight (UV radiation), infection and the subsequent immune response, metabolism of sugars related to high intensity exercise, and aging, can increase the production of Reactive Oxygen Species (ROS) such as the superoxide ion (O2-) and the hydroxyl ion (OH-). This can disrupt the natural balance and lead ultimately to oxidative stress[1]. (Figure1)[2]
The detrimental health effects that can result from prolonged exposure to oxidative stress include: DNA damage that can ultimately produce cancer and atherosclerosis (hardening of the arteries) that leads to cardiovascular disease. Oxidative stress is known to significantly contribute to the process of inflammation, which underpins conditions like rheumatoid arthritis, inflammation, metabolic syndrome and diabetes, as well as to neurodegenerative diseases like Alzheimer's[3].
Figure 1: Cellular generation of reactive oxygen species and antioxidant defense system.
Glisodin – Definition and proof of concept/ mechanism of action
Superoxide dismutase (SOD), along with catalase and glutathione peroxidase, form the front line of the body's antioxidant enzyme defenses[4]. The superoxide anion is the starting point of the cascade of reactions of free radical production.
SOD, dubbed the "enzyme of life" on discovery in 1968, is the first antioxidant mobilized by the cell as defense against oxidative stress. The enzyme reacts with the superoxide ion and turns it into hydrogen peroxide (H2O2). This is then catabolised by catalase and glutathione peroxidase to produce molecular oxygen (O2) and water (H2O).
Figure 2: Role of antioxidant enzymes in the inactivation of the superoxide ion.
These antioxidant enzymes have a distinct advantage over the antioxidants consumed from the diet or nutritional supplements, like the vitamins A, C, and E, carotenoids, and thiols since the enzymes are biological catalysts, rapidly and repeatedly reducing reactive oxygen species without being consumed themselves. By reacting early in the process, the antioxidant enzymes can minimize the potentially-harmful oxidation of a range of biological molecules. On the other hand, a non-catalytic or stoichiometric relationship exists for most vitamins, carotenoids and thiols, meaning a defined relationship exists – one vitamin C molecule, for example, quenches just one ROS. As vitamin stores can be readily depleted under extreme free radical burden, more vitamin C must be consumed to replace that which has been lost. Moreover, in this example, as Vitamin C is involved in many other essential activities within the cell, relying on Vitamin C to quench free radicals means that Vitamin C is no longer available to perform its other essential tasks; these tasks include the production of collagen, and synthesis of certain neurotransmitters to name but two.
Like most other protective mechanisms in the body, the production of SOD decreases with age[5], while a cell's susceptibility to oxidants increases, putting the cells under increasing oxidative stress.
Oral administration of SOD and the other antioxidant enzymes present in many plant extracts is, under normal conditions, not effective. During passage through the gastrointestinal pathway the enzyme is denatured (deactivated) rendering it ineffective as an antioxidant. However, studies have shown that combining a melon concentrate naturally rich in SOD with a wheat gliadin biopolymer system temporarily protects the SOD during its passage through the gastro-intestinal tract. One explanation of this efficiency was presented by Clemente et al. who showed that gliadin increases the permeability of the intestinal wall by promoting the release of a zonulin, thereby allowing the transport of the macromolecule SOD across the intestinal barrier[6].
Figure 3. Effect of a supplementation with Glisodin® on circulating SOD activity. A. Mice were fed for 28 days, with either a control diet or supplemented with (a) melon SOD extract (10 IU of non protected SOD), (b) gliadin (1 mg) or (c) Glisodin® (1 mg for 1IU).
The combination of a cantaloupe melon (Cucumis melo L.C.) concentrate naturally rich in SOD with the wheat gliadin biopolymer (Glisodin) significantly improves the delayed release of SOD as evidenced in vitro by the progressive increase of its activity in a medium mimicking the digestive conditions (Figure 3)[7].
Vouldoukis et al. have shown ex vivo that prime activation of macrophages isolated from rodents with interferon-gamma (INF-gamma) subsequently challenged with IgGl/anti-IgG1 immune complexes leads to the significant production of superoxide anions.
This production may be regulated, in a dose-dependent manner, in macrophages originating from rodents previously supplemented with Glisodin. These results prove the potent in vivo activation of antioxidant activities made by the SOD-melon concentrate/gliadin biopolymer combination [8]
An important proof of concept in vivo study by Vouldoukis et al. using Balb/c mice receiving the SOD-rich melon concentrate orally, either alone or combined with wheat gliadin (Glisodin) for 28 weeks showed that only the gliadin-SOD complex resulted in a significant increase in circulating antioxidant levels[6].
Figure 4. Gliadin polymers delay the release of the melon SOD activity in a medium mimicking the digestive process. An identical amount (100 units) of melon-SOD extract was submitted free or combined with gliadin (Glisodin®) to conditions mimicking the digestive process, for 1 h at 37 °C.
Figure 4 illustrates circulating SOD activity in mice supplemented with free gliadin, free SOD, or Glisodin, compared to control (no supplement).
Kick et al.[9] used the aortic cross-clamping technique with 18 pigs to induce ischemia-reperfusion process (IR), a well-established model of oxidative stress. After two weeks of supplementation with Glisodin (1250 mg, nine pigs) or placebo (nine pigs), the animals were subjected to aortic clamping to induce injury-related oxidative stress. Pigs were chosen to avoid confounding factors such as smoking and dietary habits, and because their tissue antioxidant profiles and susceptibility to oxidative stress are similar to that of humans.
At the end of the study, Glisodin-supplemented animals had significantly lower levels of oxidative-stress induced DNA damage. Furthermore, the researchers found significantly lower levels of apoptotic (dead) cells in the spinal fluid of the swine, showing a marked protective benefit.
Glisodin – Evidence from human studies
Glisodin was studied in a trial utilizing induced oxidative stress, thereby establishing its efficacy in humans. Similar results to the swine study were obtained in a randomized, double-blind, placebo-controlled clinical trial involving 20 men. Trials with such a design are considered the 'gold-standard' for scientific evaluation. Muth et al. assigned the volunteers (average age 31) to receive a daily dose of 1000 International Units (IU) of SOD (Glisodin) or placebo for 14 days prior to being exposed to hyperbaric oxygen (HBO) – pure oxygen at a pressure of 2.5 atmospheres – for 60 minutes. DNA damage that results in exposure to HBO was measured using the comet assay, and found to have significantly increased in the placebo group, while no significant changes were observed for the SOD-supplemented group. (Figure 5)
Moreover, the levels of F2-isoprostanes, well-accepted markers for oxidative stress, increased significantly in the placebo group (22.3 picograms per milliliter of plasma from the start of the study). No significant increases were observed in the Glisodin-supplemented group indicating significant protective benefit.
Muth et al. concluded that Glisodin was able to protect against DNA damage induced by HBO and thereby confirmed the antioxidant activity of the supplement[10].
Figure 5. Results of the comet assay measuring human DNA damage that results from exposure to HBO. Glisodin was protective while damage significantly increased in the placebo group.
Improvements in antioxidant status have also been observed in patients with HIV and AIDS, a population with reduced circulating antioxidant levels. Chenal et al. performed a double-blind clinical trial with 35 AIDS patients not receiving anti-retroviral therapy to receive placebo, non-protected SOD melon concentrate (Cucumis melo, 1000 IU SOD) or the SOD-gliadin combination (1000 IU SOD) every day[11].
At the end of 21 days of supplementation, patients receiving Glisodin were found to have normalized circulating SOD1 activity and total antioxidant status, while no such effects were observed in the placebo or non-protected SOD groups. The researchers concluded that Glisodin could improve antioxidant defenses.
Taken together these results from in vitro, in vivo and human studies show that Glisodin is bioavailable when taken orally and can significantly improve the antioxidant status of an individual.
Benefits of the antioxidant Glisodin for promoting immune health
The combination of superoxide dismutase and gliadin (Glisodin) was studied for its ability to regulate the immune response. Balb/c mice were fed a control diet supplemented with either free vegetal SOD (10 IU) or the SOD-gliadin combination (Glisodin, 10 IU) for 28 days Blood samples were taken every seven days and measures of circulating SOD, catalase or glutathione peroxidase indicate that their respective level only increased in the group receiving the Glisodin combination.
Additionally, spleen cells isolated from mice in each of the groups showed that the mice supplemented with Glisodin had increased production of type1 helper T lymphocytes (Th1) and INF-γ and IL-4. The immunoglobulin G (IgG) response – the predominant antibody used by the body to identify and neutralize foreign objects – was stimulated, while the response of IgE, the immunoglobulin associated with an allergic response, was only marginally affected.
Vouldoukis et al. proposed that the mechanism behind these effects was due to an activation of antigen presenting cells (APC), which results in the production of hydrogen peroxide (H2O2) and nitric oxide (NO), both of which are reactive oxygen species and upset the oxidant-antioxidant balance. In response to this, production of the antioxidant enzymes catalase and glutathione peroxidase is induced. This results in a polarized adaptive immune system, highlighting the benefits of Glisodin since this polarization is a sign of the natural equilibrium of antioxidants in the cells[11].
Quality of life, a measure of overall health, daily activities, tiredness, and energy levels, is an important issue for people infected with HIV and receiving highly active anti-retroviral therapy (HAART). Rahman et al. investigated the effect of receiving Glisodin-containing supplements on quality of life and performance of 23 AIDS patients on HAART. Subjects received two daily supplements of Resurgex, a blend of Glisodin (500 IU), co-enzyme Q10 (75 mg), and beta-glucans (100 mg) for up to 24 weeks.
Measures of Quality of Life (QoL) significantly improved in the patients, particularly for measure of overall health, daily activities, tiredness, and energy levels. Such improvements were supported by improvements in measures of performance status.
On a biochemical level, Rahman et al reported clinically important improvements in a number of metabolic and immunological functions, which would be tied to the improvements observed in performance and Quality of Life.
These results indicated that supplements of Glisodin could have significant benefits for the millions of people infected with the HIV-1 virus and receiving anti-retroviral therapy.
Benefits of Glisodin for physical performance & sport
High intensity aerobic exercise can increases oxygen consumption by up to 20 –fold, overwhelming our antioxidant defenses and resulting in increased oxidative stress[14]. A study by Arent et al. at Rutgers University looked at the effects of pre-season training on performance capacity and oxidative stress responses of 22 Division 1soccer players randomly assigned to receive a supplement of Resurgex, a blend of Glisodin (500 IU), co-enzyme Q10 (75 mg), beta-glucans (100 mg) and other complementary nutrients, or an isocaloric equivalent daily for the duration of preseason.
The group receiving the Glisodin supplement showed improvements in measures of lactic acid threshold and "time to exhaustion", and significantly greater reductions in oxidative stress-inducing lipid hydroperoxide levels than the control group. The researchers concluded that the Glisodin may have meaningful effects possibly including improved recovery for people exercising at a high intensity[15].
In another study with the Glisodin/ nutraceutical blend, various parameters were measured in the strength athlete using College Football players. The active group demonstrated an increase in peak power approximately 86% greater than the increase in the control group using a commercially available performance nutrition shake. Further, the active group showed significantly improved recovery parameters and inflammatory markers, including IL-6, Creatine Kinase and Isoprostanes levels as compared to control. [16]
Hong et al. recruited 44 healthy individuals and assigned them to receive a daily SOD (Glisodin) dose of 1500 IU for four weeks. Healthy volunteers were then submitted to cycling or treadmill exercise but assigned into two distinctive groups: the severe exercise group (27 subjects) or the moderate exercise group (17 subjects). Only volunteers ranging from the severe exercise group showed a significant reduction in the exercise-induced lactate production, after the four-weeks of SOD supplementation [17].(Figure 7.)
Figure 7. Effect of 4-week oral SOD administration on exercise-induced increase in plasma lactate
These studies indicate that supplementation with the gliadin-SOD complex could allow for quicker recovery for people undertaking strenuous exercise.
Benefits of Glisodin for Cardiovascular Health
Researchers from France's National Association of Medical Prevention reported that supplementation with Glisodin, in combination with diet and lifestyle changes, should significantly reduce the risk of cardiovascular disease by significantly reducing vascular inflammation, and may even positively impact on previous damage.
Cloarec et al. recruited 76 patients considered to be at risk of cardiovascular disease but free of any clinical symptoms of the disease and assigned them to diet and lifestyle changes for 12 months. Minor improvements in blood pressure, LDL-cholesterol (so-called 'bad' cholesterol) and body mass index (BMI) were reported. Due to the stringent conditions of the study 42 volunteers dropped out. The remaining 34 subjects were randomly divided into two groups, one to continue with the diet and lifestyle recommendations only, and the second group received a daily supplement of Glisodin (500 IU) for two more years.
Using ultrasound-B imaging to measure carotid artery intima media thickness (IMT), a sign of hardening of the arteries (atherosclerosis), the researchers found a reduction in the IMT in the SOD-supplemented group, compared to the diet and lifestyle only group. (Figure 8.) It is interesting to note that recent studies with statins have not shown a regression in IMT.
While no changes in antioxidant status were observed in the control group, significant improvements in antioxidant status as a result of SOD supplementation were observed. Furthermore, Glisodin supplementation produced a 34 per cent reduction in malondialdehyde (MDA) levels – MDA is a reactive carbonyl compound and a major end product of lipid oxidation. A major part of the pathogenesis of atherosclerosis, and subsequently cardiovascular disease, is the oxidative modification of LDL-cholesterol.
Figure 8. Changes of IMT at baseline, D365, D545, and D730. Upper columns: IMT in control group; lower columns: IMT in Glisodin group. While the control group experienced significant thickening of IMT, the Glisodin group experienced a significant reduction of IMT.
This study showed that supplementation with Glisodin could impact antioxidant status and the inflammatory process, and had clear benefits against atherosclerosis, a major risk factor for cardiovascular disease[18].
Benefits of Glisodin for skin health
A randomized double-blind clinical trial by Mac-Mary et al. showed that Glisodin supplementation reduced skin-reddening when healthy fair-skinned volunteers were exposed to UV radiation[19]. Fifty subjects were randomly assigned to receive a daily dose of Glisodin (500 mg) or placebo four weeks. Subjects were exposed to UV radiation to induce sunburn on the inner-forearms, and the susceptibility of the participants to sunburn (defined as the minimum erythematous dose – MED) and a measure of the resulting redness (actinic erythema).
Figure 9 shows that supplementation with Glisodin resulted in an increase in the minimum exposure to UV rays necessary to produce skin burn for fair-skinned people (phenotype II), compared to placebo. The induced redness also decreased quicker in the Glisodin-supplemented group over the four-week period. These results confirmed the efficacy of the SOD-gliadin combination against the consequences of oxidative stress produced by exposure to UV radiation.
However, in a later study of similar design with Type II (fair-skinned) participates, Glisodin significantly increased the MED in two weeks' time with a dose of just 250mg.[19]
These studies were built on two older studies; a pilot study of 15 patients who were susceptible to sun-burn supplemented with a daily dose of 500 mg Glisodin for three to eight weeks of normal sun exposure; and an open clinical trial with 150 volunteers taking a daily Glisodin supplement (500 mg) for 60 days. 86% of participants reported significant relief.[ , ]
Figure 9. Glisodin induced increased in minimum erythematous dose (MED) compared to Placebo
The role of Glisodin in suppressing inflammation
An in vivo study by Vouldoukis et al.[7] submitted C57BL/6 mice groups to various supplements for 28 days: placebo, gliadin only (1 mg), SOD only (5 IU), the SOD-gliadin combination (5 mg equivalent to 5 IU of SOD, Glisodin), or heat-inactivated SOD-gliadin combination (5 mg) for 28 days and then given an intra-peritoneal INF- injection (300 IU). Peritoneal macrophages were harvested 24 hours later and challenged with IgGl/anti-IgG1 immunocomplexes to amplify the inflammatory response. Only Glisodin reduced the production of the pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-α) and promoted production of the anti-inflammatory cytokine interleukin-10 (IL-10), compared to the other treatments (Figure 6).
Figure 6. Effects of Glisodin on production of pro- and anti-inflammatory cytokines
This result also showed that it is necessary to preserve the enzymatic activity of the administered-SOD to retain the anti-inflammatory effect of Glisodin® since IL-10 production was not observed when Glisodin was previously heat inactivated.
The anti-inflammatory effects of Glisodin are significant since chronic inflammation is associated with the onset and progression of many chronic diseases.
Moreover, Okada et al. reported that administration of the gliadin-SOD complex could prevent cancer progression, promoted by inflammation[22]. The researchers used C57BL/6 female mice implanted with a gelatine sponge (to promote inflammation) and injected with QR-32 tumor cells. The mice were then randomly supplemented with Glisodin, SOD-only or gliadin only at a dose of 10 mg per kg of body weight. While tumor growth was suppressed in the Glisodin group, the tumors in the mice supplemented with only SOD or gliadin were found to have significantly increased. The mechanism behind these effects was proposed to be related to reducing levels of the reactive oxygen species, the superoxide ion. It was also proposed that the melon SOD extract-gliadin combination may also be affecting immune response.
This result indicated that the antioxidant and anti-inflammatory properties of Glisodin might have significant benefits for the prevention of tumor development and progression.
Potential benefits of Glisodin for diabetes
Diabetes is on the rise worldwide, with diabetic kidney disease just one of the many complications of the disease. It has been suggested that high glucose levels may result in increased oxidative stress, and thereby promote the development of diabetic kidney disease (diabetic nephropathy). To test whether oral administration of Glisodin could positively impact on the pathogenesis of diabetic nephropathy, Naito et al. assigned diabetic and non-diabetic mice to receive a standard rodent diet and one group was supplemented with the cantaloupe melon extract-gliadin combination (0.08 per cent of the diet) for twelve weeks[23].
No significant differences in blood glucose levels or body weight were observed between the diabetic mice in the SOD-gliadin-supplemented group and the control group. Both diabetic mice groups had higher blood glucose levels and body weights than non-diabetics.
In terms of kidney health, significant reductions in the levels of 8 hydroxydeoxyguanosine (8-OHdG), a marker of oxidative stress, were observed in the SOD-gliadin-supplemented group. Ha et al.[24] have reported that 8-OHdG formation is closely related to the development of diabetic kidney disease in rodents, and reductions in 8-OHdG were associated with improvements in kidney health amongst the test animals used by Naito et al.
This study suggested that the cantaloupe melon extract-gliadin combination might be a novel approach for preventing diabetic kidney disease by reducing oxidative stress.
Production of reactive oxygen species (ROS) is a normal process in oxygen-breathing organisms. Under normal physiological conditions a balance between these species and the body's anti-oxidant defenses exists, but certain conditions can increase the production of ROS like the superoxide ion (O2-) and disrupt the natural balance and lead ultimately to oxidative stress.
The superoxide ion is the starting point of the cascade of reactions of free radical production. Superoxide dismutase (SOD), dubbed the "enzyme of life" on discovery in 1968, is the first antioxidant mobilized by the cell as defense against oxidative stress.
Oral delivery of the pure enzyme to boost the body's natural antioxidant defenses has been limited by the harsh conditions experienced in the gastrointestinal (GI) passage. However, combination of SOD-rich cantaloupe melon (Cucumis melo L.C.) with the wheat gliadin biopolymer (Glisodin) can significantly and progressively increase SOD stability and delivery during passage through the GI tract, as shown by results from in vitro, in vivo and human studies.
The anti-inflammatory and immune system modulating effects for the Glisodin have also been discussed, with the results showing that, while no such effects are observed when SOD or gliadin alone are administered, the SOD-gliadin combination is effective.
Such benefits can also be related to other conditions associated with oxidative stress, with significant health implications for improved recovery after strenuous exercise, reduction of inflammation (reddening) in the skin on exposure to sunlight (UV radiation), improvement in heart health, and complications arising from diabetes.
As strategies to inhibit oxidative stress and contribute towards healthy aging are considered, oral supplementation with Glisodin has been shown scientifically to offer a therapeutic means for the prevention and treatment of many conditions associated with increased oxidative stress and inflammation.
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(2) Rahman I., Biswas S.K., Kode A., "Oxidant and antioxidant balance in the airways and airway diseases" European Journal of Pharmacology, 2006, Volume 533, Pages 222-239
(3) Ding Q., Dimayuga E., Keller J.N., "Oxidative damage, protein synthesis, and protein degradation in Alzheimer's disease" Current Alzheimer Research. 2007, Volume 4, Pages 73-79
(4) McCord J.M., Fridovich I., "Superoxide dismutase: an enzymatic function for erythrocuprein (hemocuprein)" J. Biol. Chem., (1969) Volume 224, Pages 6049-6055
(5) Di Massimo C., Scarpelli P., Di Lorenzo N., Caimi G. di Orio F., Ciancarelli M.G., "Impaired plasma nitric oxide availability and extracellular superoxide dismutase activity in healthy humans with advancing age" Life Sciences. 2006, Volume 78, Pages 1163-1167
(6) Clemente M.G., De Virgiliis S., Kang J.S., Macatagney R., Musu M.P., Di Pierro M.R., Drago S., Congia M., Fasano A., "Early effects of gliadin on enterocyte intracellular signaling involved in intestinal barrier function" Gut 2003, Volume 52, Pages 218-223
(7) Vouldoukis I., Conti M., Krauss P., Kamaté C., Blazquez S., Tefit M., Mazier D., Calenda A., Dugas B., "Supplementation with gliadin-combined plant superoxide dismutase extract promotes antioxidant defences and protects against oxidative stress" Phytotherapy Research 2004, Volume 18, Pages 957-962
(8) Vouldoukis I., Lacan D., Kamate C., Coste P., Calenda A., Mazier D., Conti M., Dugas B., "Antioxidant and anti-inflammatory properties of a Cucumis melo LC. extract rich in superoxide dismutase activity" Journal of Ethnopharmacology 2004, Volume 94, Pages 67-75
(9) Kick J., Hauser B., Bracht H., Albicini M., Öter M., Simon F., Ehrmann U., Garrel C., Sträter J., Brückner U.B., Leverve X.M., Schelzig H., Speit G., Radermacher P., Muth C.-M., "Effects of a cantaloupe melon extract/wheat gliadin biopolymer during aortic cross-clamping" Intensive Care Medicine 2007, doi:10.1007/s00134-006-0518-6
(10) Muth C.M., Glenz Y., Klaus M., Radermacher P., Speit G., Leverve X., "Influence of an orally effective SOD on hyperbaric oxygen-related cell damage" Free Radical Research, 2004, Volume 38, Number 9, Pages 927-932
(11) Chenal H., Davit-Spraul A., Brevet J., Legrand A., Demouzon J., Cosson C., Dugas B., Montagnier L., Conti M., "Restored antioxidant circulating capacities in AIDS west african patients receiving an antioxidant nutraceutical Cucumis melon extract rich in superoxide dismutase activity," Abstract included at the XVI International AIDS Conference Aug 2006
(12) Rahman H., Rocco R., Latorre J., Tabassum V., "The effects of a specialized superoxide dismutase nutritional supplement for HIV patients on HAART" Millenium Biotechnologies.
(13) Rahman H., Rocco R., Latorre J., Tabassum V., "The effects of a specialized superoxide dismutase nutritional supplement for HIV patients on HAART" Millenium Biotechnologies
(14) Marzatico F., Pansarasa O., Bertorelli L., Somenzini L., Della Valle G., "Blood free radical antioxidant enzymes and lipid peroxides following long-distance and lactacidemic performances in highly trained aerobic and sprint athletes" Journal of Sports Medicine and Physical Fitness, 1997, Volume 37, Issue 4, Pages 235-239
(15) Arent S.M., DiFabio D., Greenwood J., Pellegrino J., Williams C.A., "Nutritional supplementation in male college soccer players: effects on performance and oxidative stress" Rutgers University. 2004
(16) Shawn M. Arent, PhD, "Nutritional Supplementation (Glisodin® Containing Resurgex® Formula) In Male College Football Players: Effects On Strength, Body Composition And Oxidative Stress," Human Performance Lab, Rutgers University, New Brunswick, NJ. 2007.
(17) Hong Y., Hong S., Chang Y.H., Cho S.H., "Influence of an orally effective superoxide dismutase (glisodin) on strenuous exercise induced changes of blood antioxidant enzymes and plasma lactate," presented at the American Association for Clinical Chemistry (AACC) National Meeting, July 2004
(18) Cloarec M., Caillard P., Provost J.-C., Dever J.-M., Elbeze Y., Zamaria N., "Glisodin, a vegetal SOD with gliadin, a preventative agents vs. athersclerosis, as confirmed with carotid ultrasound-B imaging" European Annals of Allergy & Clinical Immunology, 2007, Volume 39, Number 2, Pages 2-7
(19) Mac-Mary M., Sainthillier J., Creidi P., Series J.P., Vix F., Humbert Ph., "Could a photobiological test be a suitable method to assess the anti-oxidant effect of a nutritional supplement (Glisodin®)?" European Journal of Dermatology, 2007, Volume 17, Number 2
(20) Laverdet C., Pomarede N., Oliveres-Ghouti C., "Glisodin and Exposure to the Sun," an open study conducted in France on 150 patients by 40 dermatologists. Sponsored by ISOCELL Nutra, France. March 2005
(21) Laverdet C., "Glisodin Sun pilot Trial," an open study conducted in France on 15 patients presenting fragile skin, hypersensitivity to the sun or even problems of sun disease; Attachee de Consultation des Hopitaux de, Paris. July-September 2003
(19) DermExpert Trial, "Evaluation Of Glisodin's Effect On Erythema Induced By UV Radiations," Intermediate Reports, February 2006
(22) Okada F., Shionoya H., Kobayashi M. Kobayashi T., Tazaxa H., Onuma K., Iuchi Y., Matsubara N., Ijichi T., Dugas B., Hosokawa M., "Prevention of inflammation-mediated acquisition of metastatic properties of benign mouse fibrosarcina cells by administration of an orally available superoxide dismutase" British Journal of Cancer 2006, Volume 94, Pages 854-862
(23) Naito Y., Akagiri S., Uchiyama K., Kokura S., Yoshida N., Hasegawa G., Nakamura N., Ichikawa H., Toyokuni S., Ijichi T., Yoshikawa T., "Reduction of diabetes-induced renal oxidative stress by a cantaloupe melon extract/gliadin biopolymers, oxykine, in mice" BioFactors 2005, Volume 23, Pages 85-95
(24) Ha H., Kim C., Son Y., Chung M.H., Kim K.H., "DNA damage in the kidneys of diabetic rats exhibiting microalbuminuria" Free Radis. Biol Med., 1994, Volume 16, Pages 271-274


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text: Klaus Schmidinger wrote: > geronimo wrote: > > Hello, > > > > I hope it's OK to post this kind of things (it's my first post here). > > Typical beginners mistake: you have replied to an exiting post > instead of starting a new thread. Could you please extend your corrections? - what was (respect to the technical format) wrong with my first mail? - my question did not focus the technical format but the ideally format / permission. > Regarding shutdown: no more changes before version 1.4. I did not mention any version or roadmap. I just asked for (especially) your opinion. kind regards geronimo


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Welcome to the homepage of Handwrought Writing and editing.
Thank you for looking me up, but I'm no longer taking freelance work; I have contracted exclusively to a consultancy firm.
I'm sure your writing is significantly more interesting than the business writing that big companies produce… but they do so much of it.
Thanks again for stopping by.


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A year after heavily crushing on this pattern by Rachel of Stitched in Color and seriously doubting I'd ever have the sewing skills to make one, I have completed my very own Wheel Quilt. It is one of the final week's projects for Curves Class.
I love it. I love it a lot more than I expected to.
I did not use fabrics that were 'oh my god I love these so much anything they go in will be perfect!'. Instead I had two charm packs I was kind of meh about, that I'd bought early last summer. One, Good Fortune by Kate Spain, I really loved online, but when I got the charm pack I was a bit put off by the size of the prints and the punch you in the face colours confusingly (to me) combined with a wishy-washy beige-grey. The other charm pack was Birds and Berries by Lauren & Jessi Jung. It is a lovely collection, but I found the amount of turquoise in it overwhelming. Neither inspired me to come up with a pattern I really wanted to make. So they sat. And sat.
I signed up to do Curves Class and then realised I had no money to buy new fabrics for the projects. I had to rely on my stash and whatever old sheets and fabrics I had lying around my parent's house. Thankfully, I have been buying fabrics since I was a teenager and hoarding them. Way before I started sewing or quilting. But this is I think the greatest revelation of Curves Class to me. (Well, it's on a par with overcoming my fear of curves and discovering how much fun improv piecing is - seriously! Why have I not been doing this already???) Yeah, the other greatest revelation: This quilt was living in my stash AND I HAD NO IDEA!
|The backing is Turtle Bay from Prince Charming by Tula Pink. I have tonnes of this for some reason...
It begs the question - what else is living in my stash?? How do I get the vision to see the possibilities?? It's exciting and overwhelming!
This quilt finished at 38" square. The binding is the remaining charms cut into 2.5" strips. I successfully attached the binding using a combination of Rachel's zig-zag binding tutorial and Canoe Ridge Creations' double fold binding tutorial. I had tried before and failed miserably, so yay!! I can only continue to improve now I have the technique right.
I have no one to give this to, and no baby of my own to put it aside for. I will keep it though and eventually I'll find the perfect recipient for it. I'm not finished stroking it and looking at it just yet anyway!
I'm off now to try and finish up the Orange Peel Cushion for Curves Class. Then it's onwards to various horribly delayed BOM blocks over the weekend. That may be wishful thinking, but maybe by this time next week I'll have them done :)
Happy Friday everyone!
Linking up to TGIFF at Gingersnaps Quilts this week.
And to Finish it up Friday at Crazy Mom Quilts!
And to Finish it up Friday at Crazy Mom Quilts!


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But the credit card-size leisure "passes" that were available at tourist sites in and around the nearby 15th century walled town of Langres listed "le mini-golf" in precisely this spot, and if we looked carefully, we could see a crude, hand-drawn map posted on an exterior stone wall, guiding us back to a private home in an adjacent, unnamed village where, presumably, we could pick up golf balls, clubs and a scorecard.
Sure enough, we followed the directions and--voilà--there was a pleasant woman sitting in her garage at the prescribed address, happy to dig out the requisite equipment and collect 30 francs--about $4.50--for the three of us, my wife, Lucy Stille; our then-11-year-old son, Lucas; and me.
We returned to the golf course, certain from our earlier, cursory examination that on so small a course, with no one else playing, we would finish in 30 minutes, with all of us well under par.
Every hole turned out to have impossible obstacles. A brick wall right in front of one tee. Several wood-and-metal barriers in the first six feet, one after another. A mock overturned milk container and a huge piece of plastic "cheese" in the middle of a putting green. To get around the barriers, we had to hit the ball off the course--a one-stroke penalty--on at least half the holes. It was all so daunting that we spent more time giggling than hitting the ball.
On miniature golf courses at home, I usually wind up within two or three strokes of the typical par of 54; Lucy and Lucas are slightly higher. Par on this course was also 54. My score: 89. Lucy and Lucas were over 100. But the course was right next to a canal, so between errant strokes, missed putts and raucous laughter, we yelled greetings to French families floating by on their barges. The experience wound up being one of the highlights of the delightful week we spent in Burgundy last summer.
I tend to plan my vacations around restaurants, so I've always liked Burgundy--home of some of the world's finest food and wines--but the region can also be great fun for kids, as our excursion to le mini-golf helped prove. Indeed, the main reason we rented a house in this location was that it offered a little bit of everything for everyone--not just good food and wine but sightseeing, relaxation, beautiful scenery and outdoor activities.
The house, which we had rented on the Internet, was about 20 minutes from the golf course. It had three bedrooms, a modern kitchen, large dining and living rooms and a huge frontyard filled with fruit trees, rosebushes and other plants I couldn't begin to identify. It also had several fireplaces and a good selection of English-language videos--none of which we initially expected to use. After all, this was Burgundy in late July. Who would want a fire? And who goes to France to sit around watching American movies?
Guess again.
It was unseasonably chilly that week, and it rained a little almost every day--although, fortunately, almost all the rain fell while we were driving, eating or sleeping. More important, since we were on vacation we didn't have to get up early, so we could stay up late.
On three of our seven nights in the house, we lighted fires and had our own classic film festival. We saw Audrey Hepburn in "Roman Holiday" after dinner at a casual nearby restaurant overlooking a beautiful lake. We saw Ingrid Bergman in "Indiscreet" over a simple supper of bread, cheese, wine and fresh fruit on a day when we had driven two hours each way for a spectacular three-hour lunch at the Michelin three-star La Côte d'Or in Saulieu. We saw James Stewart in "Rear Window" over a dinner that Lucy cooked after a visit to the market in Dijon, the capital of Burgundy, about 35 minutes south of our house.
As it turned out, we had gone to Dijon on the wrong day--Monday, when the main open-air market was closed. We had a pleasant time there anyway--walking through the fine arts museum, which was once a ducal palace; coming upon an impromptu choral performance; admiring a 13th century Gothic church and lunching in the simple Bistro des Halles, across from the site of the market.
Even with the market closed, we were able to buy elsewhere fresh fruits and vegetables and most of the other components of the dinner we planned to have at home that night--including a strawberry cake that turned out to be one of the best desserts of the trip.
But as we left Dijon, Lucas said, "What kind of dinner will this be? We don't have a main course."
"Not to worry," I said, with more confidence than I felt. "Instead of taking the freeway back, we'll take the N74; it's the main road that runs through Burgundy. I'm sure we'll find plenty of places open with good things available."
Lucas teased me every five minutes thereafter as we whizzed through countryside that was as lovely as it was uncluttered--nary a commercial, comestible or agricultural venture in sight. Then, about 10 minutes from home, we spotted a farm with a sign advertising freshly killed chickens, ducks and geese. I pulled triumphantly into the dirt driveway.
The proprietors were out of ducks and geese, but they had chickens. We took one home. All French chickens seem to taste better than American chickens, but this one was especially flavorful--perhaps because there was a hint of vindication in its seasoning.
The next day was the sunniest and warmest of the week, so we took advantage of it to visit Lac Villegusien and Lac de la Liez, both within 20 minutes of our house. At the first Lucas swam while Lucy and I sat on the grass and read. After a picnic lunch composed mostly of leftovers from the previous night's dinner, we headed to Lac de la Liez, where we rented a pedal boat and pedaled our way around the lake for a blissful hour.
That night we had one of the two big-deal meals we had budgeted for during the week--at Lameloise in Chagny, where we met friends from Washington, D.C., and had several Burgundian specialties--including frogs' legs, snails, pigs' feet with mashed potatoes, and assorted preparations of pigeon and duck--and one distinctly non-Burgundian dish, a lobster and mushroom risotto that may have been the best dish of the night.
Two of our three wines--all Burgundies, of course--were definitely the best of the trip: a 1998 Chassagne-Montrachet, La Maltroie, from Bernard Moreau, and a 1985 Volnay, Clos des Ducs, from Marquis d'Angerville.
Burgundy is home to some of the greatest wines in the world, and those wines were the perfect prelude to my plans for the next day--"My Wine Day," as I called it, having promised Lucy that if we went to Burgundy I would not drag her through vineyard after vineyard day after day. (Lucas, who thoroughly enjoys the wining and dining experience--all the more so in France, where they happily let him taste wines in restaurants and at vineyards--did grumble, "Why can't we go to more wineries?")
We were going to visit one of my favorite Burgundy producers, Domaine Dujac, in the morning and, after lunch, drive to Beaune, gateway to the Côte d'Or, the oenophile's version of a pilgrimage to Lourdes.
It was drizzling when we made the drive, but even though I had to strain to see the signs, I still felt my pulse race as we passed the vineyards and villages known to wine lovers the world over--Chambolle-Musigny, Morey-St.-Denis, Gevrey-Chambertin, Clos de Vougeot, Vosne-Romanée. Dujac is behind a stone wall on a tiny side street in Morey-St.-Denis, marked only by a modest sign. Jacques Seysses, the proprietor, had arranged for his son Jeremy to give us a brief tour and tasting, and after we tried barrel samples of half a dozen of his 2000 wines, Jeremy opened about a dozen bottles of the '98s and '99s. When he learned that Lucas was born in 1989, he opened an '89 for all three of us to sip--and he showed Lucas the proper way to spit out wine when you're just tasting. Then, it being lunchtime, he recorked the '89 and suggested we take it around the corner to one of his favorite local restaurants and enjoy it with our meal.
Next we were off to Beaune, the home of the dukes of Burgundy until they moved to Dijon in the 14th century. The city is best known for the annual Hospices de Beaune charity wine auction, which every November draws a large, invitation-only gathering to the medieval hospital-cum-museum known as the Hôtel-Dieu.
The Hôtel-Dieu was founded as a hospital for the poor in 1443 by Nicolas Rolin, then chancellor to the duke of Burgundy. Used as a hospital until 1971, the facility was so attractively designed and so sumptuously decorated--its walls were hung with valuable works of art--that it came to be known as a "Palace for the Poor."
The building remains a stunning jewel of Burgundian-Flemish architecture, perhaps most noticeable in the steeply pitched slate roof, filled with glazed geometric patterns in gold and red and black, punctuated by weather vanes, dormer windows and a single turret topped by a 98-foot spire. The hospital has a large central courtyard and the massive "Great Hall"--165 feet long, 47 feet wide and 50 feet high, with an immense vaulted ceiling and 31 hospital beds in individual wood cubicles. The beds have been preserved as they were when they held patients--each with a red blanket and a matching set of red drapes, to be closed for privacy.
To Lucas, the kitchen was the most fascinating room in the hospital. Realistic-looking dummies of faceless nuns in habits stood over the stove and chopping blocks, one of which had six whole chickens arrayed on it. One nun was cutting up a rabbit; another was poised over a big pot, as if washing dishes.
After examining tapestries and other works of art, we strolled back out into the gray midsummer day and headed for home.
We had one more sunny day before we had to leave Burgundy, though, and that was the day we played le mini-golf. We began that splendid day by walking the ramparts in Langres, ducking into its caves and towers and sauntering through the town's open-air market. We had lunch there, sitting on a wood bench while we ate local sausages hot off the grill, then headed for what Lucas had really been looking forward to ever since we had found out about it--a go-cart course.
Like the miniature golf, the go-cart course was listed on our leisure pass, and, like the miniature golf, it was not easy to find. But once we found it, the man in charge couldn't have been more helpful--perhaps because we were his only customers.
Neither Lucas nor Lucy nor I had ever been go-carting before, and Lucy wasn't about to start in rural France. I agreed to race Lucas, though I had no idea what to expect or how this course might compare with an American track.
He is not usually a risk-taking kid, so at first I thought he might be too tentative and go too slowly to have any fun. But he is a very competitive kid, so then I worried that he would roar off at 60 mph, flip out on a curve and--well, I didn't want to think about it.
As it turned out, he was neither tentative nor reckless. He drove fast--much faster than I expected--but he did so safely, slowing at the turns (of which there were many), then accelerating down the straightaways. I made sure not to challenge him too aggressively for fear of triggering his competitive drive in a dangerous fashion.
When we finished, he was beaming. He went fast, he beat me, and his mom got lots of pictures.
What more could an 11-year-old boy ask for?
David Shaw is media critic for The Times.


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At UW-Green Bay, students experience hands-on learning from award-winning
faculty on a naturally beautiful campus. Learn more about academics,
campus life, affordability, and how to apply.
Women of Color is an organization dedicated to improving the quality of life for women of color at the University of Wisconsin – Green Bay. WOC exists to provide support academically, socially, spiritually, culturally, and serve as a positive role model to young women.
For student organization contact information and a list of all student organizations, please click on this link:
Student Organization Big List


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Amidst the hubbub of the first wave of real people getting their hands on the fabled Google Glass, something's being ignored: the Explorer programme is a tech launch, done as we've never seen before. Thing is, it hasn't been a no-holds-barred success for Google.
You've probably heard of Google Glass: basically a heads-up display for life, that theoretically lets you do lots of smartphone-y things, like checking your email or Googling stuff, without actually using said smartphone. Unveiled a year ago at Google I/O by Sergey Brin, Google co-founder and overseer of the Google X Labs, Glass has become the poster-boy of the wearable-computing craze sweeping the technology world.
One of the unusual (or 'disruptive', in Silicon-Valley-ese) facts about Google Glass is the beta-testing programme Google's undertaken. Project Glass was first launched in 2012, and full retail versions aren't expected until 2014. Nonetheless, Google launched the #ifihadglass campaign a few months ago, allowing wannabe cyborgs to tweet what they would do #iftheyhadglass. Around 8,000 lucky respondents were chosen, allowing them the chance to pony up £1,100 to buy a set of Google Glass Explorer right now. Add that onto those who pre-ordered Glass at I/O 2012 (for the same £1,100), and that creates around 10,000 people who are #wanderingaroundwithglass, almost a year before its general-public release.
This is a marked contrast to the normal state of affairs surrounding technology launches. Traditionally, prototypes are kept tethered to desks, protected by spies and FBI agents, and generally guarded like the MacGuffin in a C-rate action film. The idea behind this is that the 'unveiling' of a new product, with lots of anticipation and tension and probably scantily-clad ladies, will build a butt-load of hype around the new product, driving the Twitterati into a feeding frenzy and causing misguided souls to queue outside Apple stores for hours. It's a tried and tested formula, so for Google to be turning their backs on conventional product-launch wisdom is a brave move.
From a publicity perspective, the Explorer programme has been a runaway success. As well as netting it a cool £10 million in cold hard cash, the Explorer programme gives Google publicity and hype beyond its wildest dreams. Normally, PR firms have to give away vast amounts of stuff to get individual products trending on Twitter, but Google managed to get millions of people gagging to over-pay it for buggy software and prototype hardware. There's no doubt that in the short-term, the Explorer programme is raising cult levels of awareness around Glass; but in the longer run, Glass won't just be a niche product, but (Google hopes) a mainstay of everyday technology.
It's in this longer-term perception of Glass that Google's Explorer programme may be less than ideal. People can only sustain hype for so long, and I've got a feeling that a few months may be the limit. The evidence is clear -- Apple's winning formula, which has driven record-breaking sales figures, relies on launching a product, having a pregnant pause during which pre-orders are open and marketing ramps up, followed by the launch a couple weeks after the initial Jobs talky-talky. Products with much promise, but little by way of delivery, lose a lot of the buzz surrounding their launch, as the media coverage and marketing becomes a diluted drip-feed, rather than a slap in the face with a gigantic logo. Take the Pebble smartwatch as an example -- launch date slipped by around six months from the initial promise, and despite incredible interest around the product itself, it's faded into relative obscurity.
And loss of buzz isn't Google's only problem. Wise men (and OKCupid-bound creepers) often say that you only get to make a first impression once; that's especially true in the tech world, where attention spans are short and opinions are as in-depth as a YouTube comment. Although the Google Glass Explorer edition is a prototype, and unlikely ever to go on general sale in its current form, its well-documented flaws will almost certainly haunt further versions of Glass. Reviews have semi-slated the limited functionality and poor battery life, and while I'm sure those are flaws that will be fixed (or at least made better) before launch, that bad association is made, and will take years to shake.
Furthermore, perhaps Glass' biggest barrier to adoption is the privacy concern -- a problem that hasn't been helped by the Explorer version being hacked by an intrepid dev to take a photo with just a wink. Privacy nuts are already signing petitions and banning Google Glass from bars; the negative publicity they generate, before Google's really had a chance to address the problem, puts Glass in serious danger of being still-born.
It's a shame, because the open, transparent development procedure has a lot going for it. Beyond the transparent veil of publicity, there's a further use for Explorer: Google's got themselves an unbeatable collection of individuals, all of whom are paying to do beta testing on Google's behalf. Hopefully, this will lead to a consumer version of the tech that doesn't have any of the teething problems traditionally associated with first-gen products. That's the ideal outcome.
My only concern is that in the process of getting the perfect product, Google might leave Glass -- a project that could be the future of wearable computing -- with a mighty hangover that'll take years of some serious technological painkillers to clear. That'd be a mighty shame.


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- Employer
- USAJobs
- Location
- Arlington, Virginia
- Posted
- Apr 02, 2018
- Closes
- Apr 02, 2018
- Industry
- Government and Public Services, Federal
- Career Level
- Experienced (Non-Manager)
- Hours
- Full Time
Occasional travel - You may be expected to travel for this position.
Relocation expenses reimbursed Yes You may qualify for reimbursement of relocation expenses in accordance with agency policy.
You must be a U.S. citizen to be eligible for this position.
You must be able to submit and pass designated and/or Random Drug Testing as required.
You must be able to obtain/maintain a Top Secret/SCI clearance.
Mobility is an essential element of the DISES.
- Male applicants born after December 31, 1959, must complete a Pre-Employment Certification Statement for Selective Service Registration.
- You will be required to provide proof of U.S. Citizenship.
- Two year trial/probationary period may be required. You will serve a two-year probationary period unless you have previously completed the probationary period in the DISES.
- Appointment is subject to the completion of a favorable suitability or fitness determination, as determined by a background investigation.
- Direct deposit of pay is required.
- This position requires you to submit a Public Financial Disclosure Report (OGE 278) upon entry, and annually thereafter.
- The incumbent is required to travel on both scheduled and unscheduled aircraft, and other modes as required, under conditions specified under the DoD Joint Travel Regulations.
- The incumbent is expected to travel on short notice to attend high level meetings to obtain resolution of problems and gather information to assist in the decision making process.
- Mobility: An essential element of the DISES is mobility across geographic, organizational and functional lines. Individuals selected for Army DISES positions may be subject to reassignment that requires them to be mobile. The U.S. Army senior leadership considers mobility to be an integral part of employment as an DISES member with the Department of the Army.
If you are a current DISL, the following mandatory Executive Core Qualifications (ECQs) and Technical Qualification factor must be included. If you are an SL the following mandatory ECQ, Intelligence Community Senior Officer Core Qualification (IC SOCQ), and Technical Qualification factor must be included. Failure to meet mandatory ECQs, Technical Qualification, and IC SOCQ automatically disqualifies an applicant:
ECQ 1 - LEADING CHANGE: This core qualification involves the ability to bring about strategic change, both within and outside the organization, to meet organizational goals. Inherent to this ECQ is the ability to establish an organizational vision and to implement it in a continuously changing environment.
ECQ 2 - LEADING PEOPLE: This core qualification involves the ability to lead people toward meeting the organization's vision, mission, and goals. Inherent to this ECQ is the ability to provide an inclusive workplace that fosters the development of others, facilitates cooperation and teamwork, and supports constructive resolution of conflicts.
ECQ 3 - RESULTS DRIVEN: This core qualification involves the ability to meet organizational goals and customer expectations. Inherent to this ECQ is the ability to make decisions that produce high-quality results by applying technical knowledge, analyzing problems, and calculating risks.
ECQ 4 - BUSINESS ACUMEN: This core qualification involves the ability to manage human, financial, and information resources strategically.
ECQ 5 - BUILDING COALITIONS: This core qualification involves the ability to build coalitions internally and with other Federal agencies, State and local governments, nonprofit and private sector organizations, foreign governments, or international organizations to achieve common goals.
MTQ: Ability to manage Army's Counterintelligence, Human Intelligence, Disclosure and Security programs by providing authoritative advice, decisions, and recommendations on programs critical to the operational success and security of the Army and protection of its installations, forces, technologies and personnel. Leverage technology, and apply knowledge of doctrine, policy, federal statutes, DoD Directives and Army regulations to conceptualize, develop, and maintain Army regulations, policies and programs relevant to Counterintelligence, Human Intelligenceand Security efforts, including Personnel, Technology, Information and Industrial Security; Foreign Disclosure; Insider Threat; and sensitive Counterintelligence, Human Intelligence operations.
Intelligence Community Senior Office Core Qualification Standard-Mandatory
Intelligence Community (IC) Senior Officer Core Qualification (SOCQ) - Leading the Intelligence Enterprise: Required for all senior executive positions effective 1 October 2010. This SOCQ involves the ability to integrate resources, information, interests, and activities effectively in support of the IC's mission and to lead and leverage cross organizational collaborative networks to achieve significant mission results. Inherent to this Standard is a deep understanding of the Intelligence enterprise (or other comparable interagency or multi-organizational environment) and a shared commitment to the IC's core values. (Include a separate attachment one page maximum per competency).
(1) Collaboration and Integration: IC Senior Officers have a responsibility to share information and knowledge to achieve results, in that regard are expected to build effective networks and alliances; actively engage these peers and stakeholders; involve them in key decision; and effectively leverage these networks to achieve significant results. Senior officers are expected to create an environment that promotes employee engagement, collaboration, integration, information and knowledge sharing, and the candid, open exchange of diverse points of view.
Candidates assessed against this competency must:
a. Build, leverage, and lead collaborative networks with key peers and stakeholders across the IC and/or other government/private-sector organizations, or professional/technical disciplines to achieve significant joint/multi-agency mission outcomes.
b. Integrate joint/multi-agency activities effectively exercising collaborative plans that realize mutual IC, joint, or multi-organizational goals.
(2) Enterprise Focus: IC Senior officers are expected to demonstrate a deep understanding of how the missions, structures, leaders, and cultures of the various IC components interact and connect; synthesize resources, information and other inputs to effectively integrate and align component, IC, and the United States Government interests and activities to achieve IC-wide, national, and international priorities. Senior officers are expected to encourage and support Joint Duty assignments and developmental experiences that develop and reinforce enterprise focus among their subordinates.
Candidates assesses against this competency must:
a. Understand the roles, missions, capabilities, and organizational and political realities of the intelligence enterprise; apply that understanding to drive joint, interagency, or multi-organizational mission accomplishment.
b. Understand how organizations, resources, information, and processes within the IC interagency/multi-organizational environment interact with and influence one another; apply that understanding to solve complex interagency or multi-organizational problems.
(3) Values-Centered Leadership: IC Senior officers are expected to personally embody, advance and reinforce IC core values. Senior officers are expected to demonstrate and promote departmental and/or component values. Candidates assessed against this competency must demonstrate:
a. A Commitment to selfless service and excellence in support of the IC's mission, as well as to preserving, protecting, and defending the Nation's laws and liberties.
b. The Integrity and Courage (moral, intellectual, and physical) to seek and speak the truth, to innovate, and to change things for the better, regardless of personal or professional risk.
c. Collaboration as members of a single IC-wide team, respecting and leveraging the diversity of all members of the IC, their background, their sources and methods, and their points of view.
d. Promote, reinforce, and reward IC, departmental/component core values in the workforce and ensure that actions, policies, and practices are aligned with, and embody those values.
e. Ensure that organizational strategies, policies, procedures, and actions give appropriate focus, attention, and commitment to diversity of people, points of view, ideas, and insights.
Candidates for this position will be reviewed for receipt of joint duty credit. You must provide evidence of having obtained joint duty credit by submitting a previously approved Joint Duty Claim Form(s) or by requesting approval of a joint duty claim by submitting the Joint Duty Claim Form with supporting documentation. Your claim will be reviewed, approved/disapproved and returned to you. Information, to include forms and instructions on joint duty can be found on the JDA website by clicking the link below.
JDA Website and from: https://www.dni.gov/index.php/careers/joint-duty
**NOTE: Applicants without Joint Duty Credit may apply for the position and can be considered. If selected a Joint Duty waiver will be required prior to final appointment. An external candidate, if selected, will be required to provide proof of Joint Duty credit apply for credit prior to appointment.
FOREIGN EDUCATION: If you are using education completed in foreign colleges or universities to meet the qualification requirements, you must show the education credentials have been evaluated by a private organization that specializes in interpretation of foreign education programs and such education has been deemed equivalent to that gained in an accredited U.S. education program; or full credit has been given for the courses at a U.S. accredited college or university. For further information, visit: http://www.ed.gov/about/offices/list/ous/international/usnei/us/edlite-visitus-forrecog.html.
- If you have retired from federal service and you are interested in employment as a reemployed annuitant, see the information in the Reemployed Annuitant information sheet.
- Veteran's Preference: By law Veteran's Preference does not apply to the Senior Executive Service.
- False Statements: If you make a false statement in any part of your application, you may not be hired; you may be fired after you begin work; or you may be subject to fine, imprisonment, or other disciplinary action.
- Non Discrimination: All applicants will be considered without regard to race, color, religion, national origin, marital status, political affiliation, age, sex, sexual orientation, disabling condition, membership in an employee organization, or any other non-merit factors.
- Adverse Information Screening: Applicants proposed for selection are subject to inquiries as to any incidences of misconduct, malfeasance, neglect of duty, or the appearance thereof. Information gained in this check will be considered in the approval decision.
- E-verify: If you are selected for this position, the documentation that you present for purposes of completing the Department of Homeland Security (DHS) Form I-9 will be verified through the DHS "E-Verify" system. Federal Law requires DHS to use the E-Verify system to verify the employment eligibility of all new hires, and obligates the new hire to take affirmative steps to resolve any discrepancies identified by the system as a condition of continued employment. The U.S. Department of Army is an E-Verify Participant.
You will be evaluated for this job based on how well you meet the qualifications above.
You will be evaluated on the quality and extent of your total accomplishments and experience.Read more Security clearance Top Secret/SCI
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The world's most-cited Plant Sciences journal
in Plant Science
Technical Advances in Plant Science publishes new methods that facilitate our understanding of plant biology — from molecular to whole-plant scale.
Scientific progress is inextricably linked to the development of new technologies that allow previously intractable questions to be addressed. Technical Advances in Plant Science aims to accelerate the pace of discovery through publication of new methods that will have a significant impact on our ability to study and understand the biology of plants. The section publishes technical advances related to any type of plant (unicellular or multicellular), at levels ranging from molecules to whole organisms. Areas of interest include, but are not limited to, advances in tools for making system-level measurements (genomics, proteomics, metabolomics, etc.); computational approaches for analyzing and/or integrating large-scale datasets; methods for integrating mathematical, statistical, and/or computational models to decipher plant function and growth at any level; microscopy and imaging techniques; methods for physiological and morphological analyses; high-throughput screening; genetic tools for non-model or developing model plants; biofuel-related methods; instrumentation development; improvements to existing methods that significantly increase their utility and/or robustness; and adaptation of existing methods to plant systems. The main criteria for publication are proof-of-concept and demonstration of the application of a new research tool, along with enough information to allow readers to employ it. Significant new biological insights are welcomed but are not a requirement for publication.
Please consider the requirements for experimental studies as listed below
Indexed in: PubMed, PubMed Central, Scopus, Web of Science, Google Scholar, DOAJ, CrossRef, AGRICOLA
PMCID: all published articles receive a PMCID
Technical Advances in Plant Science welcomes submissions of the following article types: Correction, Editorial, Hypothesis and Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review and Systematic Review.
All manuscripts must be submitted directly to the section Technical Advances in Plant Science, where they are peer-reviewed by the Associate and Review Editors of the specialty section.
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Maybe the principal didn't say "I REALLY mean it!"
Edwardsville High School in Edwardsville, Ill. has expelled 12 students for a premeditated fight on November 9:
It started with a party invitation — or lack thereof. It ended in a minute-long fight and expulsions from school that could narrow the futures of a dozen young lives.
Between the dust-up in the Edwardsville High School cafeteria on Nov. 9 and a somber School Board meeting at which the expulsions were announced 11 days later, school officials say, they carefully followed a scripted process, including interviews and hearings. The students had an opportunity to bring attorneys, cross-examine, make statements and offer character witnesses.
"It's almost like a mini court proceeding," said Merry Rhoades, the Edwardsville School District's attorney.
In most states, including Illinois and Missouri, the school expulsion process proceeds behind closed doors to protect the privacy of the students. But school officials and lawyers say students are given the opportunity to mount a defense much like in a court of law.
"The school districts try to make it fair, and by law they have to make it fair," said Melanie Keeney, a St. Louis-based attorney who specializes in education law and whose firm represents the Edwardsville district.
But to at least some of the students involved in the fight, the end result doesn't seem fair at all. One parent said she was considering taking the matter to court.
Whitney Blockton is an honors student who was expelled 16 days before a planned early graduation. "I definitely take responsibility for what I did. It was wrong,'' she said. ''Fighting is never the answer. But … I think expulsion was a little too hard. I think they had already made their minds up."
A perceived slight
The feud stemmed from a perceived slight in October, when a handful of girls weren't invited to a party. Tension grew between two groups. School administrators learned of the brewing problem, and, according to Superintendent Ed Hightower, "spent an enormous amount of time with each of the students involved in an attempt to mediate and provide conflict resolution."
On Nov. 3, the administration called the parents of seven students to tell them about the problem and urged them to come to school with their children for a meeting Nov. 6. At that meeting, seven students and some parents signed a pledge saying they would try to avoid the other group and be respectful of them. If they violated the pledge, they were told, they could face police or school discipline.
But on Nov. 8, on the MySpace.com website, "both groups communicated their plans to fight" the following day, Hightower said. And on the morning of Nov. 9, they met in the commons area of the school, and several punches were thrown. There were no weapons involved, no serious injuries, and school officials and police officers broke up the fight in about a minute. Eleven girls and one boy were suspended. Some of the girls were arrested: three were charged with misdemeanors, three others spent the weekend in jail, charged with mob action, a felony.
Last week, at Hightower's recommendation, the School Board voted unanimously to expel all 12 from the district for a year.
Parents speak out
At least two sets of parents say they wish the school had contacted them earlier to let them know about the feud. William Blockton, Whitney's father, said his wife, Nicholee, had called the school to warn administrators that their girls had been threatened. Another parent, Marqueta Lott, said she tried to call the school on Nov. 8 and the morning of Nov. 9 to warn them about the fight. (The school's phone system does not take messages before and after school.)
''I feel like they are getting punished over and over and over,'' said Nicholee Blockton "I agree with the suspension, but everyone had a role." She said she believes the school should have done more than simply "monitor the situation."
Hightower says his team did everything it could to warn students and their parents about the simmering feud and the consequences of a fight.
"We've got 2,500 good kids at Edwardsville High School, and every parent thinks that his or her daughter is the absolute best kid in the world. They should feel that way," Hightower said. "But does that give them a right to go infringing on other peoples' right to an education, even if you're an honors student?"
Discipline process
In Illinois, where 3,322 public school students were expelled last year, the expulsion process is laid out in the state school code. In Missouri the process is decided district by district.
Each school, typically, has a list of expellable offenses in its handbook, and when a student commits one of those offenses, he or she is generally suspended by an administrator. Under the rules in Illinois, an administrator can suspend a student for up to 10 days.
Within those 10 days, the school can enlist the help of a hearing officer who acts as a fact-finder — which Edwardsville does — or the school board can hear the matter directly. If a district uses a hearing officer, that person holds a hearing with the student and parents, plus anyone the family wants to bring into the process — an attorney or character witnesses, for example. The officer, often a school attorney or former administrator, also talks with administrators, teachers and staff members. The officer presents a written report to the board at a special closed meeting, where the students or parents are allowed to make a final statement. Then, in an open meeting, the superintendent makes a recommendation, and the board votes on punishment.
"They can present all the evidence they'd like," said Greg Moats, superintendent of the Belleville High School District. His district expelled 25 students last year, according to state statistics, and has expelled 15 this year. "It's not necessarily a rubber stamp. They ask a lot of questions."
In the Edwardsville case, Hightower said, he sent letters to parents advising them of their rights and telling them that they would be given as much time as they needed to make their case at a hearing on Nov. 16.
At those hearings, Hightower said, the officer tape-recorded the testimony. "He reviews the evidence, the documentation, and he makes an independent assessment and he reports it to the board," Hightower said.
Neither the Blocktons nor the Lotts had attorneys at the hearings, they said. (The families of several other students could not be reached for comment.)
"We had our little hearing, then we had five minutes to make our plea," said William Blockton. "In all honesty, they had made up their minds. I apologized … I just asked them to give her one more chance."
A final decision
For Hightower, the experience was clearly a difficult one, but he said the safety considerations of other students left the district without a choice. "I have 7,500 students in this district and with violence in the schools these days, we take these issues very seriously," he said. "In my 11 years, we've expelled only 21 students. That speaks for itself.
"There's no appeals process within the district," Hightower said. "The board made the final decision."
Rhoades, the school district's attorney, said parents could appeal the decision through the courts. But, she said, school district decisions "typically aren't overturned because there's great weight given to a school administrator's authority in keeping a school safe."
The expelled students now have few choices.
"An expulsion from one public school essentially expels them from all public schools," said Cullen Cullen, the assistant superintendent at the Madison County Regional Office of Education. "They need what's called a 'student in good standing' form to transfer, and they won't have that. They can go to private schools, but there's nothing in the law that compels them to accept them."
The regional office runs a school where the students may be able to make up course work, and they may be able to pursue correspondence courses or wait for summer school.
Whitney Blockton was thinking about going to college and pursing a degree in psychology, with a minor in criminal justice. Now she's unsure how she'll earn her high school diploma.
"She has a battery on her record," her mother said. "It's going to be a struggle for Whitney."
There's some backstory here. On the day the expulsions were decided, Superintendent Ed Hightower remarked, "Generally when a fight occurs, suspensions result. What takes this incident to the next level is the calculation and premeditation involved, as well as the blatant disregard for the efforts of many professionals who attempted to help these students resolve their differences."
These young ladies were willing to get in a brawl over not receiving an invitation to a party. They were given plenty of mediation to try to resolve the dispute, and ample warnings from the school administration regarding what would happen if they escalated the dispute to the physical level. They then exhibited premeditation by planning the fight on MySpace. When they receive the consequences that they were warned about, they claim that they have been unfairly treated. How does the mother think these kids "were punished over and over?" Would it be when the students were counseled over and over to try to avoid the brawl in the first place? What else could the school district have done? What could the parents have done that might have impressed upon these young ladies that they needed to act like young ladies on the verge of adulthood?
The expulsions probably stemmed from the fact that these girls were counselled and mediated and warned, and yet they insisted on DELIBERATELY initiating a melee in the hallways of the school. How many warnings does someone need? After all that, the decision to plan and initiate a fight shows that these girls had no intention of behaving like students, but instead like a wolfpack. Despite all the best efforts of school officials, no matter what the students now say (no doubt at the advice of attorneys), they coolly decided that fighting definitely WAS the answer.
And how was the initial insult commensurate with the resolution? How was it reflective of the initial conflict? Where, in all of this, do they show any understanding of how they disrupted the learning environment, endangered others, and disregarded all attempts to help them behave appropriately? The fighters themselves could have been seriously injured. Bystanders could have been seriously injured. The adults involved in breaking up the fight could have been seriously injured. They plotted the particulars of the fight on a webpage-- newsflash, kids, these can be read by anyone, including adults!-- and then carried this willful decision to fight into the arena-- I mean, the school building.
These were not the actions of the heat of the moment, but premeditated violence. These students have demonstrated that they cannot be trusted not to disrupt the learning environment again, if they should so decide.


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I have to be honest with you. Being a stay-at-home mom was a very lonely time for me.
You see, I have four kids and I was a stay-at-home mom for 16 years. I also have two engineering degrees from Tufts University and was a Computer Engineer for 16 years prior to staying home. Even through I routinely worked over 40 hours in my "career" job, my 24/7 stay-at-home job was by far the hardest–and yet my favorite.
There were times, though, that I wasn't sure I was going to make it to the other side. I lived in a rural area and my husband worked over an hour away. I loved my kids, but I also loved adult companionship. I relished any times with adults and often hosted potluck dinners for moms and their kids.
I didn't know there there was another way. I didn't know about Arbonne.
I didn't know that I could build a home-based business working with other moms in the area.
I didn't know that I could set up weekly mom and kid meetings where we could share ideas, meals, and encouragement.
I didn't know that I could use a healthier diaper rash cream on my babies, and use other plant-based baby products on my precious treasures.
I also didn't know I could have a create enough monthly income to cover my mortgage and more.
I didn't know, but now you do. This is my "hindsight is 20/20" gift to you.
Are you a leader who would like to connect with other moms in your area? There is no better stay-at-home career than working with a direct selling company and Arbonne is the best for moms.
Find out more by sending me a message via my Arbonne Online Store. (CLICK HERE)
©Kat Frati and www.grownUPgirl.com, 2013-2019. Unauthorized use and/or duplication of this material without express and written permission from this site's author and/or owner is strictly prohibited. Excerpts and links may be used, provided that full and clear credit is given to Kat Frati and www.grownUPgirl.com with appropriate and specific direction to the original content.


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Hope you like my creations.If you pop by please stop leave a message and i will pop back and sat hi!Whilst your here please enter my candy closes on 31st October .
Great creeepy card !
greetings from sunny belgium,
Fab card :-) Lots of fun! Love 'n' hugs, Mel xx
Fab Halloween card Jude, love the images and the layout. Hope you are having a good week so far hun.
Suzi x
oh hun this is one brilliant,hallowean card just love that image,super detail too hun love hugs cheryl xx
This is really cute Jude, I'm sorry I'm with your daughter on this one lol! I actually never thought he was that attractive either then read the books and its the character that makes him so desirabele lol! Fan fun card though, adorable image and well coloured! Hugs Rebekah xx
Great card and a fun image, love the sentiment too. Thanks for joining us at Fab and Funky this week x
fabulous card Jude :-) the images are fab and the colours are perfect ,,, very spooky :-)
thanks for joining us on the Simon Says Stamp Challenge :-)
Lols x x x
Hi Jude, what a fantastic card. I love your "scary creatures". Thanks for joining us at cupcake craft challenge this week. Hugs, Denise x
Made me smile x love it x Leigh x
Cool card, fab coloring and great scene. Thanks for joining us at Fussy and Fancy.
Ha, I'm with you on the Robert Pat comment. I think he is so wrong as Edward, you so need to read the books.


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We are networks of copycats 13 September 2010Posted by MOZAFFAR in Misc.
Despite our individuality, it is in our nature to mimic others. We mimic others in our language, in our posture, in our expressions. You have to wonder what about yourself, if anything, is original. You have to wonder if there is any aspect of your life that, at some point, was not a mimicking of someone else. Thus, your individuality — beyond your individual consciousness — might be that unique combination of the various imitations in the various aspects of your person and history.
Now, we know that you will have what you have earned, whether it comes from originality or from mimicry. Ideally, much of your mimicry is a mimicry of piety, and among those acts of copying, the best would be those imitating the Prophet -p.
But, with this aspect of human nature in mind, the real question is: which of the behaviors of others trace themselves to you? What aspects of your life are others imitating? Be sure that everyone in the world cares even the smallest bit of influence. Who is there who influences more than a parent influences a child? A mother may seem to spend her entire day in the home, being told by society that she is insignificant. Yet anyone with any sight beyond the immediate moment knows that that same mother is among the most influential members of society, because she is molding the next generation. That job is alone a full time job at least as important for the future of a society as any job in society. It is unfortunate that so many mothers, rather, so many parents (mothers and fathers) have pawned off this great responsibility to part-time babysitters, screens (television, phone, internet), and empty houses. For the child will imitate his/her environment.
But, what of your peers? How often do we extol the importance and virtues of good company. With each meeting, you partake of a piece of your friend, and with each meeting your friend partakes of a piece of you.
But, there is a catch in all this: we tend to imitate the people, forces, and ideas we respect. That respect may come from love. That respect may come from intimidation. That respect may come from repulsion: evil acts, harmful acts, repulsive acts also get imitated. But, the point is that if you respect a behavior, you will seek to imitate it. Some behaviors will be within your reach, while others will beyond reach. But, if you respect a behavior, you will seek to mimic it. And if you respect a person, if you love a person, you will seek to imitate that person. You will seek to embody that person.
Thus, we see in the tradition that there is a distinction between the practice of obeying the Prophet -p, and following him -p. You may obey him out of hope, perhaps even out of fear. But, if you respect him -p, if you love him -p, you will seek to imitate him -p. And, then those who respect and love you will imitate you.
And Allah knows best.
- 1. anonymous - 13 September 2010
mashaAllah, very concise yet beautiful.


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Historic Clarysville Inn
A Tribute
Courtesy of Martin Strouber.
The scene in this postcard is taken from a lithograph housed at the Allegany County Historical Society. During the Civil War, the Inn served as a military hospital. Surrounding the Inn are numerous one story buildings constructed by the military and long since demolished. The only two story building in the picture, located to the left of the flagpole, is the Clarysville Inn. Before the war, this Inn had been serving the travelers along the National Highway for more than 50 years.
It is generally believed that the Inn was built in 1807 by Gerald Clary. Helen Straw Hinkle, in her research, sites survey records supporting this date. The Clarysville Inn served as a stagecoach stop, and as such, attained a prestige not accorded the wagoneer stops. According to Thomas B. Searight, in his history of the national road, stagecoach drivers and the inns that served the coach lines were considered to be in a "higher class" than wagoneers and the establishments catering to their needs. But the wagoneers knew how and where to have more fun.
Enlargement from lithograph 1864.
In 1894, Mr Searight observation of the Inn was: "Eight miles west from Cumberland Aden Clary, Gerald's nephew kept [an inn]. His house was a large and commodious brick building on the south side of the road, and is still standing. There was not a more popular house on the road than Aden Clary's." Later he points out that Aden Clary was well known in the early history of the road.
From Heritage Press, courtesy of
the Preservation Society
At the outbreak of the Civil War, Mary Townsend is said to have convinced her husband, M.M. Townsend, MD to use the Inn as a hospital. Dr Townsend established the hospital and continued to serve there when the army assigned a military commander to oversee operations at the hospital.
Courtesy of Lee Schwartz & Al Feldstein
As Allegany County moved toward the 20th century, ever expanding railroad service for goods and passengers, significantly impacted the traffic patterns on the National Road. The technological advances of the era gradually altered the nature and the volume of all businesses on the National Road.
The two pictures which follow are believed to be late 1800's vintage. Both photos reveal that the Inn is showing it's age, but none-the-less managed to maintain it's popularity.
Courtesy of Lee Schwartz & Al Feldstein
This photo,
circa 1895, is here through the generosity of Tom Cecil and
Charles Hill.
Click here for 300KB GIF version.
Take a close look at these two pictures. You will find many similarities and enough differences to be certain that some time has passed between the photographs. However, with the exception of some obvious aging, little has changed since the time of the Civil War.
By the fall of 1914, when Robert Bruce traveled the National Road, work on the Inn had already begun. Note that the roof no longer extends over the porch, and it appears that the upper porch has been replaced.
Photo by J.K. Lacock, from "The National Road" by Robert Bruce
Contributed by Mel Collins,Preservation Society of Allegany County
Some time during the Roaring '20, the Inn's face lift continues. Take a look at the photo below, from the collection of Walter Neff. It is now the late 1920's.
Courtesy of Lee Schwartz & Al Feldstein
The beloved Clarysville Inn underwent another major facelift as is evidenced in the postcard below. The semi-circular porch, which replaced the full length porches of the past, graced the front entrance to the Inn to the present. The exact date of this final transformation is yet to be established, but the postcard appears to be from the 1940's or early 1950's. Help establishing this date would be appreciated.
From the postcard collection of Mel Collins
We are in the process of collecting additional information about the Clarysville Inn, and will add it to the site whenever it becomes available. Contributions to this collection, in the form of additions, corrections or observations, are always welcome, and may be sent to Carol Askey. The main reason we have undertaken this effort is that on March 10, 1999, this historic Allegany County landmark was lost to future generations.
The Cumberland Times-News published articles about the destructive fire and the magnificent history of the Inn, and have graciously granted us permission to reprint the articles on this site. Click on the picture below for more about how this Inn has been a living landmark to 20th century Alleganians.
A Pictorial History Allegany County, by Lee G. Schwartz, Albert Feldstein and Joan H. Baldwin, 1980
The Old Pike: A history of The National Road, by Thomas B. Searight, 1894
The National Road, by Robert Bruce,
for the National Highway Association, 1916
Contributed by Mel Collins, Sec/Treas Preservation Society of Allegany County
Heritage Press, June, 1972, Vol. 1, No.8
Postcard Collection of Mel Collins.
Cumberland Times-News, March 10 & 11,1999, Online Edition.
© Carol Askey 1999


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The following is a list of some information that presenters will find useful in presenting Cordelia in their community.
Headshots: Cordelia has a variety of head shot that can be copied and used off this is website for you promotional materials.
Fees: vary dependent upon the special needs of the sponsor and travel time. They can be negotiated based on total budgets available; the nature of the work needed and estimated time and expense; writing budget and travel time. Email Cordelia directly for more information.
Contact: Cordelia Anderson
Sensibilities Prevention Services
3118 West Lake Street # 431
Minneapolis, Minnesota 55416