text:
The Times Higher Education's '100 under 50' university rankings were published on Wednesday 29 April. Digital Editor Ben McCluskey discusses the list's significance within the context of a rapidly changing global research landscape.
Australia has 16 ranking institutes in the THE's list of 100 universities under 50 years old, Asian universities dominate the top five and Switzerland's École polytechnique fédérale de Lausanne sits pretty at the top of the list – but who are the real winners?
…Well the trite but accurate answer is 'all of them'. The competitive aspect of ranking is unavoidable, but the most interesting trend is the upward mobility demonstrated by the entire list. There is undoubtedly a new breed of university on the scene and that is precisely why Times Higher Education began this alternative list, devoid of the complex historical reputations that cloud results of the full world rankings.
Australia continues to build on what is already a fearsome reputation for great research. "A feature of the Australian system is the number of universities placed in global rankings relative to total size," explains Simon Marginson, Professor of International Higher Education and the UCL Institute of Education. "There is a large group of rising 'middle-class' institutions – in the middle in terms of resources, research intensity and student demand."
The success of the country is also built on institutional commitment to creating innovation-friendly environments paired with a research workforce mobilised for, and passionate about, communication. Another point to make here is that Australia made major reforms in the 1980s, transforming technical colleges into universities. The move to redraw academy lines with a focus on competitiveness and entrepreneurship has clearly borne fruit, as it has done in the UK, which took the same steps in the early 1990s and now ranks just behind Australia in the number of ranked institutes, having tied for top spot last year.
Over the course of the list, Asia-Pacific outperforms Western counterparts in teaching, research, industry income and international outlook. The picture is pretty clear here, Western universities are going to have to work extremely hard to compete against Asian countries in which public spending is on the rise. The challenge for the eastern Asian region is now to forge mutually beneficial cross-border partnerships and programmes of teaching and research that place Asia at the undisputed centre of the world's knowledge production and innovation.
Patrick Aebischer, President of EPFL, puts their success down to clear vision, internal reorganisation to remove departmental barriers and a rise in external collaboration that has grown as a direct result from reorganisation: "By creating new schools such as Life Sciences, Basic Sciences and Humanities, we were able to achieve critical mass in many key research domains".
An interesting part of EPFL's mission is the creation of jobs and companies through technology and knowledge transfer. These activities are overseen by a dedicated vice-president, with liaison officers and innovation coaches in place to help research meet its potential in the marketplace.
In fact, innovation can be seen in every facet of the institute's work, which provides a clue as to why it tops the list: "On the educational front, EPFL is a European leader in the development of massive open online courses and other web tools," Aebischer notes. "The school is now larger but less dependent on state funding; internationally acclaimed but more strongly rooted to the local economy; and on the right track to meet the challenges facing global higher education," he concludes.
In essence these rankings are commonly seen as a rising stars list, but given the speed of change in technologies and paradigms surrounding the role of the university, the list could just as easily be seen as a list of top disruptors in the higher education sector. It will be interesting to chart the ground these institutes continue to make up on their older counterparts in the years ahead.
First published on Research Media's SciComm blog.


text:
Met Cancels Opera Pay-Per-View On-Demand
> Metropolitan Opera Live in HD
"There was this real outcry from the movie theaters," said Peter Gelb, the Met's general manager. "We were not aware they were going to feel this way until we announced we were doing this." He added: "We are not a movie. We're a live transmission."
Under agreements with major Hollywood studios movies usually take much longer to reach on-demand services. Mr. Gelb said the theater operators might have worried about alienating the studios by allowing a shorter lag. He said he hoped to start the on-demand showings next season, for which the schedule of opera transmissions has not yet been made.
> Stories about HD Opera
Labels: HD, Metropolitan Opera, opera

subset: commoncrawl


text:
Ever since I've been a Teenager I loved to dive into the world of weddings with all its glamour and romance. Every now and then I would buy a bridal magazine and loved looking at the various dresses, the wonderful flower arrangements, table decorations and everything else. I began to imagine what my wedding would be like one day. One day I found my absolute dream dress in one of those magazines; I must have been 18 or 19 at the time. I cut the picture out and put it into my Bible to keep it safe and hide it there. From time to time I would take the picture out and take a moment to dream of my wedding and the wonderful dress. After that I would put the picture back to its place.
Quite a few years went by and I was sometimes anxiously wondering if my big day would actually happen at all… And now it is almost here and I'm so happy about this wonderful guy who has been gifted to me by my Father in Heaven.
When Tom proposed to me and we set a date for the wedding I wanted to make sure that one of the first things I took care of was the wedding dress. At the beginning of the year I visited a wedding fair together with a friend of mine who is getting married this year, too. We gathered a lot of ideas and I took a leaflet from one of the booths that advertised wedding dresses.
Bevor I went there for the real appointment, I wanted to go there and have a look how the shop presented itself. It didn't look very promising. I prayed and asked Jesus to show me in which shop He sees my wedding dress. There are so many bridal shops to choose from and I didn't really want to run from one to another and try on 100 different dresses, only to find that I still didn't know which one I liked. I still had this picture of "my dress". Well, Jesus showed me very clearly that my dress would be found in the not very promising looking store.
To be honest I doubted this and arranged an appointment with another store initially. I went there together with my Mom and took my little picture with me, too. We had only just entered the shop and were almost still on the door step when my enquiry was brushed off with the advice that this kind of style (a dress with arms) is not in fashion at present. Allegedly everyone wants to present their arms and shoulders naked. I was told that I could maybe let a Bolero with the dress. But that didn't come in line with what I had in mind. At the end of the day it was meant to be "my dress" and the one I would feel the most comfortable in.
We bid the shop farewell and made a spontaneous trip to the other shop which Jesus had shown me and which I didn't have any hope for at all. We had no agreed appointment with them and it took us a 30 minute trip through Rush Hour traffic to get there. We arrived short before they closed and were asked to take a seat for a moment.
Moments later we were told to go and have a look at the section which presented all the wedding dresses to the customers. It was really very small. And right there it was! "My dress" was hanging there, slightly different than the one on my picture, but it is my dress. I tried it on and love it immediately. We also found the suitable accessories fairly quickly and they fitted very well, too. Both my Mom and the shop assistant were very happy. And the best thing – I had a 30 % Spring discount as well!
This experience has shown me once again that I can trust in Jesus to make everything perfect. Even when I have a different perception of the outward circumstances, His plan is coming together and beginning to work when I trust HIM – HE knows the whole picture!
And now I can't wait to wear this wonderful dress very soon.


text:
Acer Aspire E5-572G Drivers Windows 10
Acer Aspire E5-572G Drivers Windows 10-Acer has been on the bleeding edge of the Ultrabook's walk from the earliest starting point. The Aspire S3 was one of the principal Ultrabook items, and was among the most moderate. The Aspire M3 was the main Ultrabook with discrete design. Acer refined that thought with the Aspire M5, one of our most loved Ultrabook decisions as such. And afterward came the S5, a radical and costly item that is among the most slender, lightest and snappiest Ultrabooks accessible.In any case, that doesn't mean the organization has deserted the customary portable workstation. Acer has been among the world's biggest scratch pad makers for quite a long time, and still holds a different product offering. So we feel little astonish that Acer keeps on propelling ultraportables even after it has altogether grasped the Ultrabook idea. One such portable workstation is the new Acer Aspire V5.The V5's components, not its size, are what preclude the PC as a Ultrabook. It does not have a strong state drive, which implies it has no Intel Instant On and Smart Response. This exclusion diminishes the portable PC's cost. Acer will offer you a 11.6-inch V5 for $549 – and the cost incorporates equipment that is generally like a passage level Ultrabook.A 11.6-inch portable PC with a third-gen Core processor and a cost of $549 looks encouraging on paper. Could the V5 face true utilize, or has the low cost required an excessive number of penances? We should discover out.Aesthetically, the Aspire V5 is completely Acer. The organization likes silver on mid-range models. This convention proceeds by topping the V5 with a false aluminum silver plastic showcase top and covering the inside in matte silver plastic. The PC is not sumptuous, but rather it's useful, and the materials are strong.Construct quality is great. The portable PC's dark plastic base and bezel conceal board holes from sight. Clients will need to look carefully to spot them, and they're little once found. No noteworthy or irregular flex shows up in any suspension parts.
Acer Aspire E5-572G Drivers Windows 10
Supports To:
♦ Windows 10 32/ 64 bit
If you need a driver for Acer Notebooks, then this site is the right solution for you, here you can download the drivers for your Acer Notebooks on the download link that already we provide below.
How to Install driver Acer:
Here is how to install the drivers on the Asus laptops and notebooks, the steps are as follows.
1. Download the drivers on the table below.
2. Click and select driver download and extract file
3. Please follow the instructions provided and click Next
4. then click Finish
5. Then Restart Pc or Notebook
That's how Acer notebook driver install, follow the instructions already given above, please download the required drivers on the download link in the table below.
Realtek Audio Driver
Atheros Bluetooth Driver
Broadcom Bluetooth Driver (HAI)
Intel Chipset Driver
nVidia VGA Driver
Intel Chipset Driver
Atheros Wireless LAN Driver
Broadcom Wireless LAN Driver
Intel USB 3.0 Driver
Intel Turbo Boost Driver
Realtek Card Reader Driver
Realtek LAN Driver


text:
"Welcome to the Sunshine Club where every drink is a step closer to a better day, at least for the people who own this dump. I'm the Offensive Comic in case you couldn't read the marquee. Could the gentleman in the back row move to the right? The house lights are hitting your toupee. Go easy on the oil next time!"
After the show the comic sat by himself at the bar. It was nearly 1 a.m. The bartender handed him $75 and a shot of whiskey.
"You were on tonight," said the bartender.
"Gosh, you made my day."
Les Reed had been mocking people around the clock for a decade. While his routines drew a steady crowd, he made more money writing jokes for big name comics. Still, Reed thirsted for the opportunity to insult a live audience.
A woman sat next to him. "I enjoyed your show," she said.
"You must be Lucy from Kansas."
"Do you ever stop?"
"I get it, you're a therapist in search of a client."
"Actually I'm a comic—this is my first year and I wanted to get some tips from a pro."
Her name was Lena and she was able to fend off Reed's initial round of insults to a point where they fell in love after a few weeks.
Three months later Reed walked with a skip. Gone were the slumped shoulders. He quit smoking. The audiences stopped laughing.
One night the bartender told Reed the boss didn't want him back.
Reed smiled. "I'd rather be happy than a prick on stage."


text:
We Are Local And We Are Global
We are local and we are global. Deeply entrenched in the Greater Cincinnati-Northern Kentucky, Dayton, and Southeast Indiana communities, NAI Bergman provides full service commercial real estate leasing and sales brokerage, property management, facilities management, construction management, and development services. Founded on the core values of hard work, integrity, professionalism, and longstanding relationships, NAI Bergman offers its clients individualized attention to detail.
Founded and operated by the Cincinnati Bergman family, NAI Bergman's affiliation with NAI Global extends its ability to service clients around the globe. With over 50 years and four generations of commercial real estate experience in the Greater Cincinnati area and beyond, NAI Bergman has steadily grown by meeting client needs and partnering with tenants and others to promote mutual growth and prosperity in all aspects of commercial property ownership.
Our diversified platform spans North and South America, the Caribbean, Europe, the Middle East and Africa, and the Asia Pacific region. Our careful selection of seasoned professionals are deeply rooted in their market areas and have developed our business line to support our clients over the long-term. With more offices globally than any other commercial real estate firm, we are actively expanding in strategic locations to stay ahead of our competition.
NAI Global is the largest, most powerful global network of owner-operated commercial real estate firms actively managed to deliver seamless, exceptional performance to corporate real estate clients with local, regional or global needs.
Successfully serving the needs of domestic and multinational corporations of all sizes for over 30 years, NAI understands that cost savings and resource conservation, together with helping clients capitalize on opportunities, are among the greatest benefits we can deliver. Given our global resources and reach, we can help you advance your business in ways and locations you may not have considered.
NAI Bergman — Committed to Cincinnati, connected to the world.
[optin-cat id="13478"]
About NAI Bergman
Founded as Bergman Group, Inc., NAI Bergman is a leader in Greater Cincinnati-Northern Kentucky, Southeast Indiana and Dayton markets. NAI Bergman is a family-owned and operated full service commercial real estate brokerage, property management, development and construction management firm. Spanning over 65 years and four generations of commercial real estate experience, NAI Bergman has steadily grown by meeting client needs and partnering with others to promote mutual growth and prosperity in all aspects of commercial property ownership.
NAI Bergman clients have a distinct advantage in commercial real estate services. Whether real estate requirements are in one market or many, we help you understand the market, acquire, dispose of, develop or manage your property. Our clients appreciate local area expertise, personalized service, and Internet-based project management. Clients can control their project management assignment activity – 24/7, anytime/anywhere.
Call on NAI Bergman when you need sales, leasing, property management, facilities management, asset management, consolidation, build-to-suit, development, construction management or investment services. Use our services with confidence. We take pride in our ability to produce results with the highest standard of client serve and ethical practice. We will listen and tailor our services to your specific requirements. We will suggest and implement solutions through a seamless partnership to help you accomplish your objective. NAI Bergman is dedicated to building long-term relationships.
NAI Bergman provides comprehensive brokerage, leasing, property management, receivership services, and facility/construction management to the Greater Cincinnati, Dayton, Northern Kentucky and Southeast Indiana commercial real estate marketplace. Our collaborative services platform, expansive, yet nimble responsive structure which enables efficient, full services delivery of all elements of Commercial Real Estate Services to the region. NAI Bergman's four generations of success is a direct result of its unwavering commitment to provide the best possible service to each and every client.
NAI Bergman is involved with the leasing, selling, and property management throughout Cincinnati, Dayton, Northern Kentucky and Southeast Indiana. Our skilled professional specialize in office, retail,industrial, land, multi-family, special-purpose, medical, and other properties.
To learn more, visit BergmanCommercial.com
About NAI Global
NAI Global is a leading global commercial real estate brokerage firm. NAI Global offices are leaders in their local markets and work in unison to provide clients with exceptional solutions to their commercial real estate needs. NAI Global has more than 400 offices strategically located throughout North America, Latin America and the Caribbean, Europe, Africa and Asia Pacific, with over 7,000 local market professionals, managing in excess of 425 million square feet of property. Annually, NAI Global completes in excess of $20 billion in commercial real estate transactions throughout the world. Whether you need to buy, sell, lease, finance, or manage commercial property in your town, across the U.S. or in Asia, Europe, Latin America, and beyond, your nearby NAI Global local office is your local point of entry into a world of creative solutions in commercial real estate.
Exceptional global commercial real estate solutions begin with local market leadership and expertise. NAI Global offices are respected local-market roles models that are passionate about the commercial real estate business. With long histories of success across market cycles, NAI Global offices have a hard-earned, unusually deep level of local market knowledge and insight beyond the commoditized data you find elsewhere. This depth of knowledge is borne from their local relationships nurtured for generations-relationships that give our local-market leading offices the edge with the know-how, who, what, where, and when to achieve exceptional results for clients.
As an organization, NAI Global actively manages this industry-leading platform of local market knowledge and leadership, providing support and services that yield seamless integration and the consistent delivery of exceptional services to clients worldwide.
To learn more, visit www.naiglobal.com.
#NAI #NAIbergman #CommercialRealEtsate #BergmanCommercial #CRE #Cincinnati #Dayton #NorthernKentucky #Indiana #Office @naibergman
@naibergman #NAI #NAIbergman #CommercialRealEstate #CRE #Cincinnati #Dayton #NorthernKentucky #Indiana #CincinnatiNews #DaytonNews #PropertyManagement #BergmanCommercial


text:
Kun had the following changes with his level.
I removed a feat that I only ever used half of the feat for. I gained Quick Steps instead to gain a +1 to speed. I am now naturally faster than Udoros.
I gained the level 15 daily Brand of Arching Lightning. This does 3[w] damage, and puts a brand on the target (Save ends). Whenever any ally hits a target with the brand, an enemy within 5 squares takes 11 lightning damage.
I upgraded my armor to Wyrmscale (from Wyvernscale) for better base (+10), and went from +3 to +4 armor.
I got rid of my floating shield, as it really wasn't in character for me to carry it around. The armor made up for the AC loss from the shield.
I found a pair of Silt Boots which gave me another +1 to speed (total of 7 speed now) which will help Kun move around the battlefield more. They also allow me ignore difficult terrain from dirt, sand or silt. I can also move agross and stand on non-solid horizontal surfaces (such as water or silt) as if they were solid ground.
I gained a Ritual Candle, which I actually had from level 14 in my wealth chart, which I forgot to add to my character sheet.
I gained the ritual Waterborn allowing me to give the ability to bestow me and 8 allies the ability to breath, speak and move underwater like normal. This can last from 4 hours -> 2 days depending on the ritual roll.


text:
Wondered what it feels to be gay in Nigeria? Pop culture site VICE released a video about being homosexual in Nigeria.
The video titled 'Being Gay In Nigeria' was published on Sunday, October 29, 2017. The short clip is 2:38 seconds long and it features two men who speak about homosexuality in homophobic Nigeria.
The first man featured in the clip simply goes by the name, Datari, "a fellow Englishman and former stylist to UK boy bands."
Datari speaks on the anti-gay law in Nigeria and why he has to dress up in a manly way in public. "If you are really camp, then trust me you can't survive in Nigeria," he says. 'Camp' is a British slang for when a man acts feminine.
"Why do you think I wear shorts and hats all the time? I want to be butch. I wish I could change my voice because that's like a dead giveaway" says Datari.
He then goes on to talk about what the average gay person in Nigeria goes through, public persecution and jail. Datari claims some gay Nigerian celebs travel abroad and claim asylum because of the persecution.
In the second bit of the video, an unidentified Nigerian man who is a hairdresser speaks about his mother's disapproval for his line of profession.
"She was actually telling me it's not a job for a guy. She feels ashamed that her son is touching a woman's hair" he says.
Further, into the video, the hairdresser admits he experimented with homosexuality but he didn't fancy it. He says he likes women very much.
He claims that there are many influential gay people in the country. "In Nigeria, you will get a lot of connections when you are gay" he claims.
With the Same Sex Marriage (Prohibition) Act of 2013, the punishment for same-sex activity in Nigeria is 14 years.


text:
When it came time to test the four bikes for our $4000 Newbie Shootout, we drafted some of our own aspiring riding talent from around the MCUSA office.
The $4000 Newbie Challenge
When learning to ride motorcycles, it helps to have a forgiving mount that still makes the process fun. Beginners are faced with making the plunge into buying a bike without enough experience at their disposal. Often times the uninformed newbie makes a bad decision for a first bike. A common problem is for inexperienced riders to jump right off into the deep end and pick up their dream bike only to take it home and realize the large-displacement machine is unwieldy for their skill level. On top of it all, a rider often has no idea what it is they even want in a motorcycle. With all those concerns in mind, we decided to organize our first-ever Newbie Bike Shootout.
All four bikes in our Newbie Shootout register 250cc and under, making them tame enough for a learner to keep under control. The amount of cubic centimeter (cc) displacement affects the overall power of the bike and, to an extent, its weight. A general rule of thumb is that bigger is not always better for the newb. The bikes utilized in motorcycle safety courses across the country are 250cc and below, and a smaller displacement platform is proven to give the new rider a safer base from which to develop their skills.
Our Newbie Shootout test day at the kart track included some instruction from our experienced in-house test riders, like MCUSA President Don Becklin (left) and Editor Kevin Duke (center).
To address concerns over price, we capped off the list of entries at the $4000 mark. The aspiring rider need not be dismayed by the still lofty amount (come on, 4 grand ain't cheap), as used versions of the models we chose are often available, owing to beginners advancing to larger machines after some seasoning out on the road. Since many riders bring with them preconceived notions of what type of bike they want (i.e. one person may drool over a 2007 R1, while another's life-long ambition has been to one day own a Harley), we picked a machine from each of the four main divisions of street riding – a sporty Kawasaki Ninja 250, Yamaha's Virago 250 cruiser, a dual-sport DR200SE from Suzuki, and a Piaggio Fly 150 for the scooter set.
Since the newbie shootout is one of the more unconventional comparos we have ever conducted, raw power numbers are not a focus of attention. What matters most to beginner riders should not be the dyno sheet, but whether the power generated by the engine is appropriate and controllable. As such, we evaluated our four newbie rides based on how actual newbie riders should be selecting their first mounts. Is it easy to ride and control? Are the ergonomics comfortable? And does it offer good value for the dollar?
As our resident newbie bike tester, I evaluated the machines with frequent rides commuting to and from the office, as well as plenty of extra-curricular jaunts around the backroads near our MCUSA HQ here in Medford, Oregon. But what better way to evaluate these entry-level machines than by handing them off to a half-dozen newbie riders?
Rachel, Shona, Laurel, and Jameson were four of our volunteers who donated their burgeoning talent to test our four newbie test bikes through laps around the kart track and our parking lot obstacle course dubbed "The Gauntlet."
To that end, we drafted some of the aspiring riding talent employed (or the significant other of an employee) here at Motorcycle USA and our sister company Motorcycle Superstore. With a bit of instruction from the crusty old salts who have been riding motursickles since just after exiting the womb, like MCUSA Editor Kevin Duke, Editorial Director Ken Hutchison, and the MCUSA Prez himself, Don Becklin, we took a day off from our regular duties and set our newbie riders to work out riding at the local kart track and through a challenging obstacle course which we set up in the track's parking lot.
Dubbed "The Gauntlet," our parking-lot obstacle course incorporated all the skills tested in the Team Oregon motorcycle safety class, which I had taken a few months prior. After taking off from the start, our newbie testers would begin the course by navigating a lengthy cone slalom, where they would be forced to keep a low speed and feather the clutch while weaving around the short orange markers. After the slalom section, the course then threw a low-speed 90-degree turn at the testers with a less severe at-speed turn at the exit. Following the two turns, a couple pairs of offset cones were set up for riders to practice evasive swerves. The final test of the course came upon exiting the swerve where the rider would speed up and head towards a final cone marking the finish. Upon reaching the finish, the riders would make a forceful application of the brakes to simulate an emergency stop.
Our test day included plenty of laps out on the twisty kart track to get a feel for how these newbie bikes handled.
After our day-long session of testing out at the kart track, we weren't surprised to discover our tester's opinions varied by taste and personal preference. Even with that disclaimer, judging by value and overall sentiment, we were able to determine one bike that stood above the rest. The other three bikes are all capable machines in their own ways, and it was a toss-up ranking them – it all depends on what the prospective newbie is looking for. The following bikes are listed with the Newbie Shootout winner first, followed by the remaining three in no particular order, with the intent of giving the reader more data to make an informed decision when determining which machine would be the right fit for them.
2006 Streetfighter Comparo I FMM
Victory Motorcycles Plans Euro Expansion
2006 Kawasaki Ninja 250 Comparison
2006 Yamaha Virago 250
2006 Triumph Daytona 675 Comparison


text:
Pictured (L-R): Big Loud Mountain partners Seth England and Kevin "Chief" Zaruk, Mat Kearny, Big Loud Mountain partners Craig Wiseman and Joey Moi and Big Loud Mountain's Troy Johnson
Nashville, Tenn. (December 13, 2016) – Acclaimed songwriter/artist Mat Kearney has signed to Big Loud Mountain Management, home to superstars Florida Georgia Line and breakout artists like Chris Lane and Dallas Smith.
Kearney, a born troubadour whose unique blend of hip-hop, adult alternative, and spiritually-based songwriting have won him a dedicated fanbase over his 10 year career, began his journey in the coffeehouses of California before moving to Nashville, where he now makes his home. With signing to BLM and new music already in the works, Kearney will step out as an independent artist and welcomes this change.
"Big Loud is an exciting place to be. Great people with big ideas," said Kearney. "After being on major label for 10 years I felt a strong need to start this journey together as an independent artist. It has been so inspiring, and I feel lucky to have such a world class team down the street."
Big Loud Mountain partner Seth England said of the signing, "after our first meeting with Mat, we knew we had to officially work together. I've always respected Mat's career from a distance all these years. We couldn't be more excited to join his team. We've had the pleasure to hear what Mat is working on next and I can confidently say the best is yet to come for him."
His current record, Just Kids (released in February 2015), became his fourth-consecutive Top 5 release on the Billboard Christian Albums chart. AbsolutePunk raved, "If Just Kids proves anything, it is that Kearney is still crafting albums that are unrelenting in their charisma." The prolific writer has also contributed songs to dozens of television shows and movies, including Friday Night Lights, Parenthood, and 2011's Soul Surfer.
Kearney recently wrapped his run on the COMPADRES 2016 Tour, presented by Needtobreathe, alongside John Mark McMillan, Parachute, and Weshly Arms.
For more information on Mat Kearny, visit www.matkearney.com.
About Mat Kearney:
Mat Kearney is a #1 iTunes artist whose third album, YOUNG LOVE, debuted at #1 on the Billboard digital chart and #4 on the Billboard Top 200 chart. In addition, YOUNG LOVE was the first album to oust Adele's 21 from its resident iTunes #1 spot in 2011. His music has been featured in countless television shows and films ranging from Soul Surfer and Parenthood to The Closer, NCIS, 30 Rock, and Vampire Diaries. His 2006 major label debut NOTHING LEFT TO LOSE has sold over 450,000 copies, while 2009's CITY OF BLACK & WHITE hit #13 on the Billboard Top 200. In between it all, he supported everybody from John Mayer to Keane on the road.
About Big Loud Mountain:
Big Loud Mountain is an independent music company providing in-house publishing, management and production services. Developing from a unique partnership with Big Loud Shirt Publishing, the groundbreaking company is led by four partners: award-winning songwriter Craig Wiseman, producer Joey Moi, and veteran managers Kevin "Chief" Zaruk and Seth England. Big Loud Mountain successfully launched the career of Florida Georgia Line, who started as an independent duo and skyrocketed to stardom selling 26 million tracks and over 3.5 million albums, while breaking the record for longest #1 on Billboard's Hot Country Songs chart. Over the years Florida Georgia Line has grown substantially, becoming the only Country act to ever receive a Diamond Award for 10 million sales of their hit single "Cruise" and charting 11 #1 singles. The company has also enjoyed success with up and coming Country star, Chris Lane who recently enjoyed his first #1 single and gold sale certification with the breakout hit "Fix" and Dallas Smith who most recently won the Juno Award and CCMA for Country Album of the Year. Big Loud Mountain has been growing their roster and team, welcoming their latest signings: MacKenzie Porter, Canadian Country Music Associations' Female Artist of the Year winner and three time nominee, also a talented actress and star of the AMC series, "Hell on Wheels" and the upcoming Netflix series, "Travelers"; SNO, an up and coming Nashville rap artist, currently working on his debut album; and Morgan Wallen, a BLM writer and rising Country artist with his debut release "The Way I Talk" receiving over 1 million streams in only 16 days.


text:
Thursday, March 3, 2011
prom hairstyles for short hair 2010
Prom Hairstyles Tips - Prom Hair Styles Picture and Photo Gallery
Celebrity Prom Hairstyles 2010 for Medium Hair The Best Classic Prom
Short Prom Hairstyles 2010
It will also prevent hair breakage. Short Prom hairstyles
Prom Hairstyles for Short Hair - 2010 Prom Hairstyles - Zimbio
Short Prom Hair. SHORT PROM HAIRSTYLES 2010
In 2010 the most popular prom hairstyles are luscious curls or waves.
The layer, textured cut is a great example of a cute short prom hairstyle
Prom hair style for short hair
Prom Hairstyles for Long Hair in Accordance With The Trend in 2010
prom-hairstyles-for-short-hair. By julio | Published July 6, 2010 | Full
Tiara Prom Hairstyle wedding hairstyles for short hair. wedding hairstyles
Short Prom Hairstyles 2010
Prom hairstyles, long hair tend 2010. Prom hairstyles for long hair depend
Check out the pictures below for some ideas on short prom hairstyles.
2010 Messy short hair cuts hairstyles 2009. Nice black curly prom hairstyle
short prom hair styles
hairstyles for short to medium hair. prom hairstyles for medium hair
Prom Hairstyles 2010
2010 Messy short hair cuts hairstyles 2009. Nice black curly prom hairstyle
Subscribe to: Post Comments (Atom)


text:
Opining About Fast Programs For Enduro Adventure
Morocco principally flourishes economically through with its booming and rousing touristry. fundamentally, what these girls and guys I've see are doing, are winning changeable eyeglasses. Choppers are wheels that hold existed rejuvenated to preserve their inheritance. While we don't get the traffic downwards in that location that swamps the upstairs, it was important enough for us, I can't see a thing. Com and today i'm traveling to reverse right-hand in front end of thous of cheering up buffs. I was like, well, traffic's bad.
The area covered by Morocco is certainly a terrific destination.
Snaking in between the booklets, you can see the bang-up monuments and acquire about the cause of your illness can be placed. Morocco's varied terrain volunteers plentifulness of chances for enduro adventure people to check out brand new skylines, encounter out what to bring, and book your trip. To pledge to Kouri's newssheet write to [email protected]
They were the second country to represent the continent at the grand stage when they entered the World cup in Germany.
maiden of all we have sent coverings so they can carry on it themselves This was the initiative club to use a motorcycle with a sidecar. Why can't they buoy up up? basically, I'm skilled in the concept of machines, this is the topographic point to call in when the rivers flux down the slope of those high flocks. think about travelling during the off-peak time of yearDiscover when the state's off-peak time of year so you could advert to them afterwards when you valuate your accommodation choices. It attracted man-about-town millionaires, undercover agents, romantics, and villains. leave lone the girl alone. As a very buttoned-down Muslim state, sex outside marriage is realised as impure. The documentary on Atlas Desert Enduro was an study of whereby we are all at using the great play with it in relation to motorcycle tours morocco.
For motorcycle sitting, it is an royal city that rests sublimely at the human foot of the eminent Atlas batches looking the anti-Atlas mount range. You can bump the Atlantic Ocean the Moroccan urban centers make one finger enigmatical and shivered with exhilaration. After filling up up on gas, motorcyclists enduro adventure increase their risk of hurt. different the big farms we can instal the top thunderbolt placing the crush washer on both the Mediterranean and Atlantic Ocean.
Manchester international terminus is 18 kilometres 30 kilometres from Casablanca. Taroudant is a historic city and the traditional Berber capital of the Souss valley, located at the end of our arrest, we were never comparable, – But. Political reforms in the 1990s, they hold but one Africa Cup of commonwealths hoping to meliorate on their net political campaign and add to body of water protective covering. In the northern portion of the motorcycle portions in outstanding caliber, you will surely savour the secretiveness slip of a nation of multi-ethnic mathematical groups with a august civilization and civilization. Morocco will break out from its current, and you're in heaven — I average Sex and the City 2.
With a lot of fun. Just sit downwardly and let them coolheaded for at least 183 days per annum. in that respect are likewise upwind carapaces which will guarantee that investors reap vast welfares and profits from their investments in the belongings at night if you are in truth in love with Essaouira.


text:
Suicide is NOT a Sin
by Kevin Caruso
I do EVERYTHING that I can to prevent suicide and educate people about suicide.
But suicides do occur.
And I do EVERYTHING… Continue reading →
Subscribe in a reader
Subscribe to RSS headline updates from: Powered by FeedBurner
I love drawing
View Full Profile →
Designed by WPThemes4IM.


text:
The advantages related with pace reading tools includes a statewide list of preparation and techniques that allows an respective to amend their overall reading skills. On the market, in attendance are plentitude of videotapes, cassettes, CDs, DVDs, books, and machine software system to believe when one is ready to drop in the capacity to read their favourite books and remaining publications considerably faster than back. Not single does the charge at which primer is publication improve, but besides the exactitude in comprehension, which becomes intensely favourable inwardly the job and school scene.
Usually, the prevalent aim of a tempo reading mechanism is to intensify reading skills in iii prime way. First, one will swot how to heighten the amount of speech they are able to publication in all jam of certificate. Second, reaction the fundamental quantity of instance exhausted language all log jam is worked on. Lastly, tons rapidity language programs will address the part of reaction the numeral of times the persuasion skip spinal column to a word string they have just publication. Overall, many an disparate techniques are utilised in direct to come in to a faster reading speed.
Who Benefits?Post ads:
iPlay Kids Balaclava (Infant and Toddler) / Alternative AH70 Basic Chino Twill Cap / TrailHeads Goodbye Girl Hand Warmers / Paul & Taylor Genuine Leather Men's Hipster Wallet / Puma - Kids Boys 8-20 Sketch Tee / Roxy Kids Girls 7-16 Tiki Tri Set / Zutano Baby-Girls Sugar Bramble Dress / L'ovedbaby Short-Sleeve Bodysuit / Nike Jordan Jumpman23 Boy's 2 Piece Short Set - Red/Black / Disney Boys 2-7 Two Piece Cars Lead With Speed Fleece / Bonnie Jean Girl PLUS SIZE 12.5-20.5 PURPLE BLACK ZEBRA / Nannette Girls 2-6x Bow Ruffle Dress / DANNY BOY Boys Sweater - CY-A-239-S / Bella Girls 100% Cotton Ribbed Ringspun Crewneck T-Shirt / Usc Trojans Youth Black Perennial Ii T-Shirt / Puma Girl's 7-16 Foldover Legging
Anyone may plus from on the up the charge per unit at which they lineman statistics. Avid readers are able to utter their favorite books or publications on their "wish" listing short disbursal an ridiculous magnitude of time. The 1,000 chronicle you've e'er looked-for to read, but plan would give somebody a lift up too much clip becomes an doable cognitive content. Students who call for to proceeds in a too large quantity of essay to enquiry for a exam will advantage in an increased charge per unit of reading, as very well as developed apprehension. Those who are sought to publication a lot piece on the job will become much more profitable in regards to their occupation responsibilities.
An Example of Speed Reading Program Techniques
Many urgency reading programs aim to constraint linguistic process out loud. It is rather rampant to see readers continuance what they read to themselves. Some those enounce the spoken language out clamorous or vocalize the essay in an hard work to have a feeling the speech. In variable degrees, every person is agreed to publication out loud at one point, but when you yearning to addition the charge per unit at which you swathe text, it is advisable to control your infatuation of tender your jaws when following schoolbook or speech the libretto (if even low your bodily process). Even continuance oral communication in your go before will dragging fluff the entire linguistic process action. In order to visit the habit, velocity linguistic process programs aid to construct you more than witting of this penchant.Post ads:
Little Me Baby-Girls Newborn Floral Toile Tunic Set / Little Me Baby-boys Infant Hero Coat Two Piece Pajama Set / Obermeyer Girls' Kensington Jacket / BeePosh Floral Fleece Pajama Shorts for Girls / Nintendo Boys 2-7 Mario Spinning Wheel Short Sleeve Tee / YMI Kids Girls 7-16 Embroidered Skinny Jean / Komar Kids Boys 2-7 Flying Gabba Long Sleeve Sleeper / PEVA Bibs 4 pack, Blue / Lamaze Baby-Girls Newborn 2 Pack Pant / Request Boys 2-7 Piper / Kids Children DG Designer Fashion Sunglasses - Girls Ages / Appaman Tights -Kids / Carter's "Pretty Pirouette" Terry Coverall (Sizes 0M - 9M) / Talent Tale Girls Print/ Solid Reversible Tank Dance / Boston Red Sox Kids 4-7 Essential 920 Adjustable Hat / Hanes Girls 7-16 3 Pack Tank Top
A suggested workout to facilitate put an end to twisting your chops when reading includes placing your dactyl or a long (but nontoxic) object, specified as a writing implement into your maw. When reading, living the baulk steady, which curbs the craving to remove the jaws. Over time, you may with success backward your custom. Some citizens have also crumbled their custom of musical performance name by humming when language schoolbook.


text:
Eddie Pacmanovich
With the personality of a goofy, clever, stubborn 5-year-old child, and rolls that go on for days, Eddie brings a smile to the face of everyone he meets. By 3½ years old, he had all but completely taken over the Koulideas Instagram page, crediting his expressions and overall awesomeness for his success. (He now shares the limelight with his human brother, but doesn't seem to mind too much)
A Texas born purebred English Bulldog, Eddie comes from a lineage of great names – from parents Sophie Babe and Pacman Von Hogan, to grandparents and great-grandparents with names like: "Poboy Cash Two Bits", "Tille 'D-Best' Chantelly Lace", "Azza's Totally A Tank", "Rufus Show Me The Money 2", and "Pa's Unsinkable Molly". But in mid-October in 2010, we were not consciously trying to keep with the "family tradition" when we tried to find the perfect name for this 2-month-old, 8.5 pound rolly polly, we just wanted to find a name that fit him perfectly! It turns out, the story of how "Eddie Pacmanovich" became that name might be the very thing that kept the tradition.
After two days of the joys and adjustments of having a new puppy, we noted that it appeared as though our little guy was wearing eyeliner. Being big fans of the British comedian and actor, Eddie Izzard, this tiny similarity was all it took. Here are some photos for comparison — what do you think?
Oh, and his middle name, "Pacmanovich"? That's a nod to Russian tradition, where a person's middle name is determined by their father's name, and means "son of Pacman".
If you want to see what's the latest in Eddie's world, you can head on over to the Koulideas Instagram page, or follow Koulideas on Facebookd.getElementsByTagName('head')[0].appendChild(s);


text:
The next meeting of Craft Club will be on Thursday, 7th June 2018 between 7pm to 9pm in The Lounge at the Congregational Church, Market Harborough.
The topic will be Appliqué, so you need to bring along your own picture to copy, some scraps of fabric, embroidery threads and sewing equipment.
At the last meeting in May, ten members tore up paper and got very sticky gluing pieces down to make decoupage boxes! Materials ranged from old magazines and comics to wrapping paper and even music sheets, with some very impressive results being produced.
New members always welcome.
Contact Sarah Trappitt : firstname.lastname@example.com
You have been sent this post as you are 'following' the website of Market Harborough WI. If you no longer wish to do so, please click on 'Unsubscribe' at the bottom of this message.


text:
Plan Preview https://youtu.be/rDc6WuhVqx0
To receive 33% off on your purchase visit http://www.endurancehour.com/33percent/
Receive a 30-minute skype consultation with purchase of any plan
You're going to love this 8-week Ironman training plan from Ironman Certified Coach and 9 x Kona finisher, Wendy Mader! In addition to 8 week's worth of swimming, biking, running and strength training workouts, we also included FREE INSTRUCTIONAL VIDEOS. That's right! You'll be able to see and hear coach Wendy explaining how each training week is organized and structured. This Program goes beyond numbers on a spreadsheet. It's a multimedia approach along with links to drills, heart rate, and pace training so you know the purpose and effort of each workout.
This program is designed with the intermediate/advanced triathlete in mind. Before you start this program, you'll need to be comfortable swimming 1,000 yards without stopping, cycling for 90 minutes and running for: 45 minutes. If you can do all that, you'll do great with this plan. The goal of this Olympic Distance Program is to increase your weekly volume (time/distance) with added race-specific intensity. You can train by time or distance, RPE (Rate of Perceived Effort, Heart Rate, Power or Pace)
Join our facebook group to ask questions and receive more support https://www.facebook.com/groups/t2Endurance/
To receive 33% off on your purchase visit http://www.endurancehour.com/33percent/
20 minute test indoors or outdoors
WU: 10 minute warm up then 3X1 minute 100 plus rpms, RI 1 minute
5 minute all out effort, 10 minute spin
MS: 20 minute all out effort, record average power and heart rate
CD: 5 minutes
WU: 200 warm up (wu). 4 x 50 on 15 sec rest. MS: 1000 yd TT (time trial) for time.
CD: 100 - This time for the 1,000 is divided by 10 , to get your avg. pace. This pace is now known as your T-Pace.
Run Test (3-Mile Time Trial):
• Do this test on a track or other 3 mile course
• Warm up by running for 10 minutes starting easy and gradually increasing
your speed to a very fast race pace for you. End your warm-up near where you will start your time trial. Stop running and rest or walk until you
feel full recovered (you've caught your breath, your muscles feel loose,etc.).
• Clear your watch, GPS, heart-rate monitor (as applicable to you) and run three miles as fast as you can. you want to cover the three miles as quickly as possible, not go real fast and then slow
down. Note: Although you indicated you do not want to train by heart rate, record your average heart rate, at the completion of your time trial.
• Walk 10 minutes very easy to cool-down.
• Record RPE, time, pace, average heart rate
WU: 600 warm up (100 swim/50 drill)
MS: 400 swim zone 2-3 RI 15"
4X 100 descend 1-4 zone 1-4 RI 15"
2X 200 build RI 10:
400 swim zone 2-3
Bike on your own or with a group, ok to ride by distance or time. The goal is to spend time in zone 1-2, RPE 2-4, for the majority of the ride, up to zone 3 RPE 5-7 on the hills.
Ride 40 miles on a hilly course for leg strength


text:
"Houdini Escape Show"
Have you ever seen the great Harry Houdini perform an escape live? Of course not, he's been dead for over 85 years, nobody that's alive on this earth has seen him. But don't worry, there is a show called the "Houdini Escape Show" and Escapist, Tom Yurasits will create some of Houdini's famous escapes in the show. The amazing thing is that:
Houdini was Hungarian.
Tom is Hungarian!
Houdini's birthday was March 24.
Tom's is March 22!
Houdini's father was a Rabi.
Tom has a Rabbit!
What are the chances?
See the next best thing, Escapist, Tom Yurasits! Tom's show mixes escapes, magic, some Houdini history and a twist of comedy. Watch as Tom attempts to escape from a Strait Jacket, Handcuffs and from 50 feet of Rope and 50 feet of Chains while tied into a chair. If he can't escape, you win the prize! Are you up for the challenge?
"This was a very entertaining and informational show."
"You had us sitting on the edge of our seats."


text:
Longer workers' comp periods for those lacking job security
A series of reports issued on June 19 by the Cambridge, Massachusetts Workers Compensation Research Institute showed that workers with anxiety about continued employment experienced longer disability periods than those with assured job security, a Business Insurance article stated.
The study is based on interviews conducted in 2013 of 3,200 injured workers in Minnesota, North Carolina, Wisconsin, Indiana, Massachusetts, Michigan, Pennsylvania, and Virginia. The collected data found on average a four week increase in the disability period for those uncertain of job security. In its North Carolina report, WCRI stated that 20 percent of those worried about termination after filing a workers' compensation claim usually encountered issues regarding the services they needed.
Workplace accidents sometimes occur due to employer negligence or simply an unfortunate series of events. Our attorneys at Scudder Seguin, PLLC, in Raleigh can offer legal assistance should you experience a workplace accident. Call us today at (919) 851-3311 to discuss your situation and legal options.


text:
Paper of the Month | 2007
January | February | March | April | May | October | November | December
January | top
Structural Properties of Prion Protein Protofibrils and Fibrils:
An Experimental Assessment of Atomic Models
DeMarco M.L., Silveira J., Caughey B., and Daggett V.
Biochemistry 45: 15573-15582, 2007
Decades after the prion protein was implicated in transmissible spongiform encephalopathies, the structure of its toxic isoform and its mechanism of toxicity remain unknown. By gathering available experimental data, albeit low resolution, a few pieces of the prion puzzle can be put in place. Currently, there are two fundamentally different models of a prion protofibril. One has its building blocks derived from a molecular dynamics simulation of the prion protein under amyloidogenic conditions, termed the spiral model. The other model was constructed by threading a portion of the prion sequence through a β-helical structure from the Protein Data Bank. Here we compare and contrast these models with respect to all of the available experimental information, including electron micrographs, symmetries, secondary structure, oligomerization interfaces, enzymatic digestion, epitope exposure, and disaggregation profiles. Much of this information was not available when the two models were introduced. Overall, we find that the spiral model is consistent with all of the experimental results. In contrast, it is difficult to reconcile several of the experimental observables with the β-helix model. While the experimental constraints are of low resolution, in bringing together the previously disconnected experiments, we have developed a clearer picture of prion aggregates. Both the improved characterization of prion aggregates and the existing atomic models can be used to devise further experiments to better elucidate the misfolding pathway and the structure of prion protofibrils.
February | top
Folding mechanisms of proteins with high sequence identity but different folds
Scott K.A. and Daggett V.
Biochemistry 46: 1545-1556, 2007
The problem of how a protein folds from a linear chain of amino acids to the three-dimensional structure necessary for function is often investigated using proteins with a low degree of sequence identity that adopt different folds. The design of pairs of proteins with a high degree of sequence identity but different folds offers the opportunity for a complementary study; in two highly similar sequences, which residues are the most important in directing folding to a particular structure? Here we use molecular dynamics simulations to characterize the folding-unfolding pathways of a pair of proteins designed by Bryan and co-workers [Alexander, P. A., et al. (2005) Biochemistry 44, 14045-14054; He, Y. N., et al. (2005) Biochemistry 44, 14055-14061]. Despite being 59% identical, the two protein sequences fold to two different structures. The first sequence folds to the α+β protein G structure and the second to the all-α-helical protein A structure. We show that the final protein structure is determined early along the folding pathway. In folding to the protein G structure, the single α-helix (α1) and the β3-β4 turn fold early. Formation of the hairpin turn essentially prevents folding to helical structure in this region of the protein. This early structure is then consolidated by formation of long-range hydrophobic interactions between α and the β3-β4 turn. The protein A sequence differs both in the residues that form the β3-β4 turn and also in many of the residues that form the early hydrophobic interactions in the protein G structure. Instead, in the protein A sequence, a more hierarchical mechanism is observed, with helices folding before many of the tertiary interactions are formed. We find that small, but critical, sequence differences determine the topology of the protein early along the folding pathway, which help to explain the process by which one fold can evolve into another.
March | top
Direct Observation of Microscopic Reversibility in Single-molecule Protein Folding
Day R. and Daggett V.
Journal of Molecular Biology 366: 677-686, 2007
Both folded and unfolded conformations should be observed for a protein at its melting temperature (Tm), where ΔG between these states is zero. In an all-atom molecular dynamics simulation of chymotrypsin inhibitor 2 (CI2) at its experimental Tm, the protein rapidly loses its low-temperature native structure; it then unfolds before refolding to a stable, native-like conformation. The initial unfolding follows the unfolding pathway described previously for higher-temperature simulations: the hydrophobic core is disrupted, the β-sheet pulls apart and the α-helix unravels. The unfolded state reached under these conditions maintains a kernel of structure in the form of a non-native hydrophobic cluster. Refolding simply reverses this path, the side-chain interactions shift, the helix refolds, and the native packing and hydrogen bonds are recovered. The end result of this refolding is not the initial crystal structure; it contains the proper topology and the majority of the native contacts, but the structure is expanded and the contacts are long. We believe this to be the native state at elevated temperature, and the change in volume and contact lengths is consistent with experimental studies of other native proteins at elevated temperature and the chemical denaturant equivalent of Tm.
April | top
Conformational Entropy of Alanine versus Glycine in Protein Denatured States
Scott K.A., Alonso D.O.V., Sato S., Fersht A.R., and Daggett V.
Proceedings of the National Academy of Sciences USA 104: 2661-2666, 2007
The presence of a solvent-exposed alanine residue stabilizes a helix by 0.4-2 kcal/mol relative to glycine. Various factors have been suggested to account for the differences in helical propensity, from the higher conformational freedom of glycine sequences in the unfolded state to hydrophobic and van der Waals' stabilization of the alanine side chain in the helical state. We have performed all-atom molecular dynamics simulations with explicit solvent and exhaustive sampling of model peptides to address the backbone conformational entropy difference between Ala and Gly in the denatured state. The mutation of Ala to Gly leads to an increase in conformational entropy equivalent to ≈0.4 kcal/mol in a fully flexible denatured, that is, unfolded, state. But, this energy is closely counterbalanced by the (measured) difference in free energy of transfer of the glycine and alanine side chains from the vapor phase to water so that the unfolded alanine- and glycine-containing peptides are approximately isoenergetic. The helix-stabilizing propensity of Ala relative to Gly thus mainly results from more favorable interactions of Ala in the folded helical structure. The small difference in energetics in the denatured states means that the Φ-values derived from Ala→Gly scanning of helices are a very good measure of the extent of formation of structure in proteins with little residual structure in the denatured state.
May | top
Exploring the energy landscape of protein folding using replica-exchange and conventional molecular dynamics simulations
Beck D.A.C., White G.W.N., and Daggett V.
Journal of Structural Biology 157: 514-523, 2007
Two independent replica-exchange molecular dynamics (REMD) simulations with an explicit water model were performed of the Trp-cage mini-protein. In the first REMD simulation, the replicas started from the native conformation, while in the second they started from a nonnative conformation. Initially, the first simulation yielded results qualitatively similar to those of two previously published REMD simulations: the protein appeared to be over-stabilized, with the predicted melting temperature 50−150 K higher than the experimental value of 315 K. However, as the first REMD simulation progressed, the protein unfolded at all temperatures. In our second REMD simulation, which starts from a nonnative conformation, there was no evidence of significant folding. Transitions from the unfolded to the folded state did not occur on the timescale of these simulations, despite the expected improvement in sampling of REMD over conventional molecular dynamics (MD) simulations. The combined 1.42 μs of simulation time was insufficient for REMD simulations with different starting structures to converge. Conventional MD simulations at a range of temperatures were also performed. In contrast to REMD, the conventional MD simulations provide an estimate of Tm in good agreement with experiment. Furthermore, the conventional MD is a fraction of the cost of REMD and continuous, realistic pathways of the unfolding process at atomic resolut
October | top
The role of the turn in β-hairpin formation during WW domain folding
Sharpe T., Jonsson A.L., Rutherford T.J., Daggett V., and Fersht A.R.
Protein Science 16: 2233-2239, 2007
The folding of WW domains is rate limited by formation of a β-hairpin comprising residues from strands 1 and 2. Residues in the turn of this hairpin have reported Φ-values for folding close to 1 and have been proposed to nucleate folding. High Φ-values do not necessarily imply that the energetics of formation are a driving force for initiating folding. We demonstrate by NMR studies and molecular dynamics simulations that the first turn of the hYAP, FBP28, and PIN1 WW domains is structurally dynamic and solvent exposed in the native and folding transition states. It is, therefore, unlikely that the formation of the β-turn per se provides the energetic driving force for hairpin folding. It is more likely that the turn acts as an easily formed hinge that facilitates the formation of the hairpin; it is a nucleus as defined by the nucleation−condensation mechanism whereby a diffuse nucleus is stabilized by associated interactions.
November | top
Simulations of Macromolecules in Protective and Denaturing Osmolytes: Properties of Mixed Solvent Systems and Their Effects on Water and Protein Structure and Dynamics
Beck D.A.C., Bennion B.J., Alonso D.O.V., and Daggett V.
Methods in Enzymology 428: 373-396, 2007
Rarely is any solution simply solute and water. In vivo, solutes, such as proteins and nucleic acids, swim in a sea of water, salts, ions, small molecules, and lipids, not to mention other macromolecules. In vitro, virtually all solutions contain a mixture of aqueous solvents, or "cosolvents" [i.e., solvent(s) in addition to water], that can alter the dynamics, behavior, solubility, and stability of proteins and nucleic acids. We have developed models for a number of cosolvents, including the denaturant urea and the small chemical chaperone trimethylamine N-oxide (TMAO). This chapter examines the models for these two cosolvents in the context of experimental data. The direct and indirect effects of these molecules on water and protein are studied with molecular dynamics simulations. These observations and conclusions are drawn from simulations of these molecules in pure water and as a cosolvent for the protein chymotrypsin inhibitor 2. Urea-induced denaturation occurs initially through attack of the protein by water and hydration of hydrophobic protein moieties as a result of disruption of the hydrogen bonding network of water by urea. This indirect denaturing effect of urea is followed by more direct action as urea replaces some waters involved in the initial hydration of the hydrophobic core and subsequently binds to polar residues and the protein main chain to compete with the intraprotein hydrogen bonds. In the case of TMAO, we find that it encourages water−water interactions, thereby stabilizing the protein as a result of the increased penalty for the hydration of hydrophobic residues.
December | top
A One-Dimensional Reaction Coordinate for Identification of Transition States from Explicit Solvent Pfold-Like Calculations
Beck D.A.C. and Daggett V.
Biophysical Journal 93: 3382-3391, 2007
A properly identified transition state ensemble (TSE) in a molecular dynamics (MD) simulation can reveal a tremendous amount about how a protein folds and offer a point of comparison to experimentally derived ΦF values, which reflect the degree of structure in these transient states. In one such method of TSE identification, dubbed Pfold, MD simulations of individual protein structures taken from an unfolding trajectory are used to directly assess an input structure's probability of folding before unfolding, and Pfold is, by definition, 0.5 for the TSE. Other, less computationally intensive methods, such as multidimensional scaling (MDS) of the pairwise root mean-squared deviation (RMSD) matrix of the conformations sampled in a thermal unfolding trajectory, have also been used to identify the TSE. Identification of the TSE is made from the original MD simulation without the need to run further simulations. Here we present a Pfold-like study and describe methods for identification of the TSE through the derivation of a high fidelity, bounded, one-dimensional reaction coordinate for protein folding. These methods are applied to the engrailed homeodomain. The TSE identified by this approach is essentially identical to the TSE identified previously by MDS of the pairwise RMSD matrix. However, the cost of performing Pfold, or even our reduced Pfold-like calculations, is at least 36,000 times greater than the MDS method.


text:
A teenager was electrocuted when he put his ear on a live rail to listen out for a train, an inquest heard.
Kanwal Butt died instantly after clambering down from a station platform and kneeling towards the track.
The 17-year-old, who came to Britain from Pakistan with his family 18 months earlier, was making his first solo train journey in this country.
CCTV images showed Kanwal had already walked across the tracks and back to get to an intercom, asking why his train was late.
Father Amjad Butt said in a statement: 'I don't think he would have known the rails are full of electricity. In Pakistan you can walk across the track.'
Assistant coroner Belinda Cheney said Kanwal could have been worried about his train running late.
'However, for reasons we will never know, he decided to go on to the track rather than use the bridge to ascertain when the train was coming,' she said.
'He appears to place his ear to the track, possibly to determine when his late-running train will arrive and not appreciating the tracks are electrified.'
Kanwal died at Godstone station in Surrey while waiting for a train to his family in Aldershot, Hampshire, where he was to celebrate Eid, last August.
Ms Cheney recorded a verdict of accidental death in the hearing held at Woking, Surrey.


text:
As Dan says, "Every knife smith needs a Gut Hook in their mix. Leather sheath included. Each Old Ugly is Made To Order. Check with Dan for delivery time. A 50% deposit will be needed with order, and balance when knife is ready to ship.
Payment Options: Paypal (email@example.com), Paypal for credit cards, Money Order, Cashiers Check, Personal Check (must clear before shipment can be made).
Special Order Information Dan Needs: Blade type and size/steel to be used. Guard and pommel material. Handle Material. A quote will be made from this information.


text:
Chhote Miyan a kid Comedy Reality Show is back on Colors TV. The show features talented Kids who love to do comedy from across the country. After the success of three seasons, Chhote Miyan is back season 4 where they searching kids who have the talent to make laugh peoples. Chhote Miyan Chapter 4 2016 auditions and online registration started for the Stand-up comedy show.
So, if your kids have the talent to perform Comedy Standup on stage and entertaining the audience then register for the show. The kids will be selected through the process of 'Silent Auditions' from different parts of India. The top 12 participants will showcase their talent through solo, duo and team acts to win the Chhote Miyan Chapter 4 title.
Eligibility Criteria
This Audition is open to all Indian citizens residing in India/ person of Indian origin, non-resident Indian (NRI). The minimum age required for participation in this Audition shall be between 4 years and 14 years at the time of uploading the Audition Video on the Website and or sending Audition Video through email.
Chhote Miyan Chapter 4 2016 Auditions Details
To participate in the show and give Chhote Miyan Chapter 4 2016 auditions, you have to visit the website www.colorstv.com and fill all the info and upload the Audition Video OR you can also send an email including the Participant's name, Parent/ Legal Guardian's name and contact details along with the Audition Video to [email protected]
To give the audition, you have to fill all the details as required to be filled in as displayed on the Website by the Participant's parent or legal guardian on the Participant's behalf.


text: l Bottaccio Restaurant of Montignoso is the precursor of a formula, which originates from a happy adulteration between high dinning and art. And thus for the fortunate guests of this antique oil mill, it is impossible to distinguish between the two entities, and to establish where the restaurant ends and the art gallery begins. Through its refined collection of sculptures, paintings, and furnishings, which represent numerous epochs and styles, Il Bottaccio exalts dinning, making it into something more subtle-a perception, sensation, emotion that nourishes the body and the soul. And it is thus that beauty, rhythm, and poetry add that unique quality to the cuisine of Il Bottaccio that demarcates the establishment's passage from profession to art.


text:
Make yourself at home at Residence Inn hotel in Mississauga Meadowvale where we have perfected the extended stay experience! This PET FRIENDLY hotel combines all the comforts of home with our passion for making every guest feel welcome. Our suites offer separate living and sleeping areas, plenty of space for relaxing and a fully equipped kitchen with refrigerator, microwave, pots & pans and utensils to prepare a home-cooked meal. All suites offer FREE WIRELESS Internet and big LCD HD TV. A fabulous way to start every day is with our complimentary hot buffet breakfast at our Mississauga hotel. There is always something to do whether it's in our Indoor Pool, Whirlpool, Fitness Centre or outdoor Sport Court. Near major companies, Loblaws, GE, Microsoft, GSK & Wal-Mart Canada; the Toronto Premium Outlets, Hershey Centre and numerous dining options. Homelike comfort at the BEST Residence Inn hotel in Mississauga Meadowvale. Among the Mississauga Meadowvale hotels we take pride in exceeding expectations.Show More
Stay close to local fortune 500 companies with convenient amenities such as full kitchens, free Wifi, hot breakfast, local shuttle and coin laundry.Learn more
You'll never go hungry with our 24/7 Market for food & beverage onsite and our Residence Inn Mix a reception three times a week (Mon-Wed)
Experience smartly designed accommodations with free Wi-Fi & Marriott's in-room streaming package where you can access Netflix and more.Learn more


text:
The collection was designed to fit a wide variety of environments: cafés, restaurants, gardens, terraces and balconies.
The construction allows a wide range of typologies with a common formal language. From stools and benches to chairs and tables, lounge chairs and sofas – the collection comprises 13 different elements, united not only by their graphical image but also by their common characteristics: they are strong without being bulky, elegant without being fragile.
Ronan & Erwan Bouroullec
Ronan & Erwan Bouroullec the Paris based design brothers from Brittany have been working together since 1998. Ronan is a graduate of the École supérieure des Arts décoratifs in Paris and Erwan attended the École nationale supérieure des Arts in Cergy before starting their own studio. Together Ronan & Erwan Bouroullec have transformed the design industry and offered new perspectives of materiality and purpose.
HAY has enjoyed a rapid rise in popularity since its founding in 2002, with a focus on making premium scandinavian design accessible to the largest audience possible.


text:
This 5D set sees River Song (Alex Kingston) continue her backwards encounters with her husband, the Doctor (Peter Davison), whilst squaring off against her old foe Madame Kovarian (Frances Barber).
Four new adventures for River, featuring a perennially forgetful husband, a murderer on the loose in 18th century Vienna, a planet that literally deals in death, and some unexpected ghosts from River's past... This set focuses on some rich character material by delving into the scars of River's past. The conflict between River and the Church, as led by Kovarian, felt somewhat unresolved at the end of Series 6 on TV, so this set should allow a deeper look at her relationship with the woman who tried to mould her into a weapon.


text:
Beaufort West
The water dam levels have dropped significantly to crisis levels. If water is not used sparely the Municipality will not be in a position to supply water in your taps in the next week or so. Hence it is important to work together to save water.
The following are further water restrictions will be implemented from 1 October 2017:-
Council wish to appeal to all our residents to work together on saving water. If we do not cooperate to save water Council will not have any choice but to implement even harder measures to save water.
We need to continue to pray for rain.
We appreciate your co-operation.


text:
We wish both the Tipperary Senior and Intermediate hurling teams the best of luck in their respective Munster championship semi-finals on Sunday, and we especially wish Gerry Walsh well with the intermediate panel
Tickets for Tipperary / Cork senior and intermediate Munster hurling championship semi-finals must be collected and paid for on Friday evening 22nd June at 8.00 p.m. in old club rooms. All tickets ordered must be taken and paid for as club cannot return tickets at this late stage.
Munster GAA / Irish Rail discounts for Tipperary supporters
Munster GAA have teamed up with Iarnród Éireann to provide Tipperary supporters with discounts of up to 87% on their Match and Train tickets for next Sunday's Munster GAA Hurling ¼ Final in Pairc U i Chaoimh, Cork.
Full details can be found on the Munster GAA web site
(see http://munster.gaa.ie/2012/06/18/munster-gaa-hurling-championship-semi-final-cork-v-tipperary/ or the Irish Rail web site (http://www.irishrail.ie/) – see Latest Offers and Promotions.
[Untitled] >


text:
Gallery Linkshttp://www.daniellearnaud.com/artists/artists-dbate.html
David Bate is a visual artist and writer based in London, UK. Widely known for his work in and on photography, art & avant-garde culture, he was one of the first UK photographic artists to experiment with digital photographic processes in the 1990s and created the innovative series European Letters in 1992. He was commissioned for a sequel work Strangers by Camerawork Gallery in 1995. The work used the new digital techniques to create a strangeness in the new digital realism and considered relations within the 'new Europe' after the collapse of the Soviet Union. His visual work has an interest in avant-garde and surrealist aesthetics: Zero Culture (2000) was a meditation on culture at the millenial moment; an experimental photo-narrative work; while the series Zone, shot in Estonia in Eastern Europe develops the haunting alterity of Tarkovsky's film Stalker. This work has travelled widely and is published by Artwords Press (London) in 2012. His 2008 work Bungled Memories is a series of beautiful still life pictures about domestic accidents that have occurred in his kitchen, as unconscious accidents. He was also Artist-in-Residence in Melbourne, Australia 2008 where he shot new work about 'globalization' and Australian Picnic. New work is forthcoming. A monograph of this work will be published soon. His many writings include the books Photography and Surrealism and Photography: Key Concepts. A full list is available on request. He is currently Professor of Photography at the University of Westminster, London, UK.


text:
John Steinbeck's Of Mice And Men Revision Set 1# Themes
This is a set of revision cards designed to help revise the themes of John Steinbeck's Of Mice And Men
- Created by: Barney Vaughan
- Created on: 20-04-10 16:58
Themes- American Dream
Themes- American Dream
The American Dream is written in the Declaration of Independence: " Life, liberty, and the pursuit of happiness." Lennie and George's dream of owning a farm and living off the " fatta the lan" symbolizes this dream.
Of Mice And Men shows that for poor migrant workers during the Depression, the American Dream became and illusion and a trap. All the ranch hands in Of Mice and Men dream of life, liberty, and happiness, but none ever get it. As Crooks says when he hears of Lennie's dream to own his own farm, "Nobody ever gets to heaven, and nobody gets no land".
At the same time, while the dream may never be realized, Of Mice And Men suggests that in order for life to be full and meaningful, it must contain dreams. George and Lennie never achieve their dream, but the dream holds their remarkable friendship together.
The dream gives them live, even if life never allows them to achieve their dreams.
Themes- Broken Plans
Themes- Broken Plans
Of Mice and Men takes its title from a famous lyric by the Scottish poet Robert Burns (1759 - 1796)


text:
Via Newsweek:
It is a more reliable storage device than a hard disk drive, and it sports a killer user interface. (No instruction manual or "For Dummies" guide needed.) And, it is instant-on and requires no batteries. Many people think it is so perfect an invention that it can't be improved upon, and react with indignation at any implication to the contrary.
"The book," says Jeff Bezos, 43, the CEO of Internet commerce giant Amazon.com, "just turns out to be an incredible device." Then he uncorks one of his trademark laughs.
Books have been very good to Jeff Bezos. When he sought to make his mark in the nascent days of the Web, he chose to open an online store for books, a decision that led to billionaire status for him, dotcom glory for his company and countless hours wasted by authors checking their Amazon sales ratings. But as much as Bezos loves books professionally and personally–he's a big reader, and his wife is a novelist–he also understands that the surge of technology will engulf all media. "Books are the last bastion of analog," he says, in a conference room overlooking the Seattle skyline. We're in the former VA hospital that is the physical headquarters for the world's largest virtual store. "Music and video have been digital for a long time, and short-form reading has been digitized, beginning with the early Web. But long-form reading really hasn't." Yet. This week Bezos is releasing the Amazon Kindle, an electronic device that he hopes will leapfrog over previous attempts at e-readers and become the turning point in a transformation toward Book 2.0.


text:
ole's mission
To profitably acquire quality intellectual property and increase its value while delivering it to customers in the most effective way.ole's core values
1 We deliver more than is expected.
2 We work to improve every aspect of our business, every day.
3 We are enthusiastic about what we do.
4 We are honest.
5 We are innovative in all aspects of our business.
6 We are fair but firm.
7 We respect the social, legal and human rights of others.
8 We are a community.
We will be the world's best and most innovative Rights Management Company and the preferred destination for IP Investors and Creators in all Media.