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It's been a while. We've been in a whirlwind of baby prep. We got all new furniture for our living room and had to move hubs out of his office and turn it into a suitable nursery. Our parents were amazing, helping us set things, move things out, paint, and buy furniture. I never imagined we would have such a wonderful setup to bring our little fella home to!
In addition to all the moving and setting up, I have been working and trying to get ready for the holidays, which has been hard to focus on with my one track mind lately. This past weekend, we were finally completely set up minus the car seat which my parents decided to take care of. My dad took it upon himself as "grandpa" to research and pick out the car seat in a very serious manner; something we just put in his hands.
I've been having a lot of braxton hicks contractions. They were rarely painful, just annoying mostly, but they were almost daily. My doctor assured me that even in regular intervals, they were normal and not to worry. Monday I had a regular appointment after work and I had scheduled an appointment for my grandmother that day too to save an extra trip. My mom came with me to help get us both where we needed to be on time.
Monday morning I felt bad and left work half an hour after I got there. I was having contractions, but they were intense and I had a hard time standing through them. I waited for my appointment, but on the half hour drive there the contractions got much worse. I managed to make it to the office in tears and lots of pain. My doc checked me quickly, announced I was only a fingertip dilated, but extremely soft and obviously having regular contractions. He sent me to be monitored at L&D with a shot of terbutaline to stop the contractions since I was only 35 weeks. They stopped by the time hubs got to the hospital and we decided to take advantage of the lull on the way home to grab some last minute things at the store.
On the way home the contractions hit me like a truck once again and became very strong and regular at three minutes apart and lasting a minute. We waited three hours with lots of water and rest, but ice was moving in and we decided it would be safer to head on back to the hospital. Again I was hooked up to monitors and given terbutaline to stop the contractions, but this time it didn't work. I was given a second dose, but my heart rate wouldn't regulate enough for a third dose. They decided to try fluids and pain meds instead, which finally lowered the intensity although they were coming every minute or so and lasting 40 seconds. They decided since I wasn't dilated, that I could go on home and just wait it out. I was warned that the contractions probably would not stop until delivery, but that until I reached 37 weeks, there was nothing anyone would do anymore to stop or speed them up.
I have been at home since. I am on my fourth day of prodromal labor, although my contractions are not the typical type with irregular patterns. I go through bouts of 5-8 hours with extremely intense and painful contractions that always last two to three minutes apart and a minute long. I rest or sleep in the few hours without contractions, but my body is very sore and tired already and I almost always wake up from a new stretch of contractions starting. Last night things changed. The baby is very very low now and there is tons of pressure and pain in my back and pelvis. The contractions feel different now too. There is a lot more pain with them, but they feel like they are actually doing something. I haven't had any timeable contractions today though. I feel like once they start up in a regular pattern again, we will have a baby. I don't want to wish him here too early, but the pain and stress on my body is really starting to take its toll. It's worth every single moment though. For now, we just wait and pray.
Thursday, December 12, 2013
1 comment:
- SuzyEllen said...
Awwwwww sounds like little miracle man wilk be here before Christmas! Congrats and Merry Christmas!
- December 15, 2013 at 11:59 AM
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Taking all of the actions on this page may not prevent an abuser from discovering your email and Internet activity. The safest way to find information on the Internet is to go to a safer computer. Use of your home computer to visit this site can be tracked by someone in your home. You may want to use a computer in a public library, a friend's house, your workplace or an internet café.
For help call the National Domestic Violence Hotline: 1-800-799-SAFE (7233) TTY 1-800-787-3224 or contact us at 775-883-8278 or toll free at 1-866-448-8276.
Other safety suggestions: Change your password often, do not pick obvious words or numbers for your password, and make sure to include a combination of letters and numbers for your password.
Email: If an abuser has access to your email account, he or she may be able to read your incoming and outgoing mail. Even if you believe your account is secure, make sure you choose a password he or she will not be able to guess.
If an abuser sends you threatening or harassing email messages, you can print and save them as evidence of this abuse. These messages may also constitute a federal offense. For more information on this issue, contact your local United States Attorney's Office.
History/cache file
Many browsers offer a private browsing option, but you must enable it BEFORE you view the websites. If an abuser knows how to read your computer's history of cache file (automatically saved web pages and graphics), he or she may be able to see information you have viewed on the Internet.
You can clear your history or empty your cache file in your browser's settings*
- In the top right corner of the browser window, click the Chrome menu.
- Select History.
- Click the button Clear browsing data. A dialog will appear.
- From the drop-down menu, select how much history you want to delete. To clear your entire history, select the beginning of time.
- Check the boxes for the data you want Chrome to clear, including browsing history.
- Click the button Clear browsing data.
- Click the Menu
- Choose
- And then choose Clear Recent History.
- Select how much history you want to clear.
- Click the drop down box next to Time range to clear and make your selection.
- Click the arrow next to Details to select exactly what information will get cleared.
- Click Clear Now. The window will close and the items you selected will be cleared.
- Pull down Tools
- Select Internet Options.
- On General page under Temporary Internet Files, Click on Delete Files. If asked, check the box to delete all offline content.
- Still within the Temporary Internet Files section, click on Setting (This step may make it harder to navigate pages where you would like your information to be remembered, but these remaining cookies do show website pages you have visited. Therefore, use your own judgment as to whether or not to take this next step).
- Click on View Files.
- Manually highlight all the files (cookies) shown.
- Hit Delete.
- Close that window, then on General page under History section, click on Clear History.
- Pull down the Edit
- Select
- Click on Navigator or choose Clear History.
- Click on Advanced .
- Select Cache.
- Click on Clear Disk Cache.
- Pull down Members
- Select Preferences.
- Click on WWW
- Select Advanced.
- Select Purge Cache.
Online Auto-Complete or Auto-Fill
Additionally, you should make sure that the auto-complete feature is NOT in use. This function will complete partial web addresses while typing location in the address bar at the top of the browser.
- Click the Chrome menu on the browser toolbar.
- Select
- Click Show advanced settings and find the "Passwords and Forms" section.
- Deselect the Enable Autofill to fill out web forms in a single click
- Click the menu
- Choose
- Select the Privacy
- Remove the check mark next to Remember search and form history.
- Click OK to close the Options window.
- Click Tools in the upper right hand corner.
- Select Internet Options from the dropdown menu.
- Under the Content tab, in the Auto-complete section, click the Settings
- Within this window, unclick all of the checkboxes to indicate that nothing be stored.
- Click OK
*This information may not completely hide your tracks. The safest way to find information on the Internet is at a local library, a friend's house, or at work.
For help call the National Domestic Violence Hotline: 1-800-799-SAFE (7233) TTY 1-800-787-3224

subset: commoncrawl


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Practice makes one perfect and that adage also works for people who love to golf. It is very important especially for professional players to have regular and smooth-flowing training to help them enhance their skills. Here are some of the best golf training aids that you will definitely need!
Sony Camcorder
Of course, you will need a video camera, camcorder or a digital camera to be able to record all your training sessions and review them later. It is recommended to buy something to video tape your swing so that you can look for the changes you want to make and then re-record to measure your progress. Some of the well-known brands are Panasonic, Sony and Casio. Also, a tripod would be very helpful to keep it in its place and be able to ensure that the angle is consistent.
User-Friendly Video Software
There is a lot of computer software that allows you to be able to edit your training videos. With these software, you can draw lines and even make side by side comparisons. Specifically, software such as Cswing and V1 allow you to be able to email swings and screen shots to people for their personal libraries. When it comes to tablets, the V1 app is very user-friendly and for Mac users, the Analyzr Golf software is the one to have.
Smart Body Golf Leverage Discs
To be able to clearly understand the weight shift and lateral movement and to be able to strengthen the legs during the swing, balance discs will be able to help create an incredible sense of proprioception. After a few swings on these, golfers will be more aware of imbalances in their swing and have a better concept of the role of the ankles, knees, and hips during the swing.
Last but not the very least, if you want to improve your swing without having complicated positions and mechanics, then you definitely have to get a power chute for yourself to be able to help you feel and control what your body has to do to keep the acceleration going.
Compression Board
Simplicity is the key here. The club must be working downward with an iron in order to hit the ball solidly, which is why this product is great for practice. With this, you will have an automatic feedback telling you whether your club hit the board and where your divot started. It's flexible where it can be used for chipping as well as putting.


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Roslindale Farmers Market and Local Ethnic Gourmet Shopping Tour
Saturday, 10 a.m. to 1 p.m., June – October
This is a 3 hour guided tour through Roslindale Village, with Personal Chef Lester Esser of one of the most popular farmers markets in Boston and over a dozen surrounding ethnic and gourmet shops. While less well-known than some other neighborhoods, Roslindale is an up-and-coming destination for foodies – called a "Food lover's paradise " by the Boston Globe as well as a "Top spot for foodies."
We begin the morning with a quick meet and greet, before heading to the Roslindale Farmer's Market, where we will visit farm stands, talk with farmers and local food producers, and discover new items to add to your dinner table. I will give you shopping tips, storage and recipe ideas. After we meet the vendors, you will have time to revisit the farm stands to complete any personal shopping. Every visit is unique, depending on the seasonal items. There is nothing more satisfying than buying produce directly from the person who grew it.
We will then visit Rozzie's local shops, including European-style bakeries, Greek, Mexican and Lebanese markets, Italian grocery and butcher shop, gourmet cheese shop, Halal butcher, and boutique wine store – a variety you will not find anywhere else in Boston! As we make our way through this selection of food purveyors, I give examples for preparing and serving the many items we will explore.
This is a fun learning experience for anyone interested in healthier eating, local shopping, ethnic and artisan foods and learning about this great Boston neighborhood.
This shopping adventure is open to individuals and groups. It makes a great outing for mother's groups, foodie friends, healthy eating groups, team building with employees or coworkers. Call to schedule a group tour or to find out about joining a regularly scheduled tour.
The tour can be custom designed to include a cooking lesson using the food items we've discovered and/or dinner that I will prepare for you. Roslindale Village also welcomes you to enjoy many of the excellent restaurants in the Square, that will be pointed out during the tour.
A tour of just the local markets can also be arranged outside the farmers market season.
It is recommended to bring your own reuseable shopping bags and if you are traveling very far by car, a cooler with ice packs or ice to keep your purchases fresh. Please plan on 3 plus hours.


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Democracy on the streets
Over the last six months or we have seen people take to the streets all over the world in protest over gay rights, bus tickets, parks, austerity measures and constitutional changes. All of them in countries with a democratically elected government .
So are these protests successful and what do they mean for democracy? Is this is a crisis for democracy or a liberating way to hold governments to account? Social media played a huge role in the protests so will we eventually see a democracy app?
- Associate Professor Bessma Momani
- Associate Professor at the University of Waterloo's Balsille School of International Affairs
Senior Fellow, the Brookings Institute and the Centre for International Governance and Innovation
Further Information
- Interviewer
- Amanda Vanstone


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Last week, The Wall Street Journal reported that Verizon will not offer the Samsung Galaxy S II in US. This news surprised many because the latest flagship handset of Samsung, the Galaxy S II, has been a hit all over the world. According to reports, Samsung has sold 5 million Galaxy S II in 85 days. But now, things are appearing to make sense after the latest report by BGR.
According to BGR, Verizon has given up the offer of launching the Samsung Galaxy S II in return of getting a bigger and better offer. The report suggests that Verizon will launch the much awaited successor of Google's Nexus S, the Nexus Prime (reports suggest it will be called DROID Prime) as exclusive, which will be made by Samsung. The device is suggested to be launched by Verizon as soon as October. The Nexus Prime/ DROID Prime will be the first device to sport Android 4.0 a.k.a. Ice Cream Sandwich. The model number of the device will be SCH-i515.
Verizon probably made this move because the Samsung Galaxy S II may find hard to stand against Apple's iPhone 5, when it will launch in near future. And having the device, which will be the first device to sport Android 4.0, that too as an exclusive is a huge boost. It seems that Verizon's subscribers will have the bragging rights in the end.


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Weave in various items from questionnaire and other sources to present a coherent picture of a person functioning highly competently…
That word—picture—combined with the context of selection-based algorithms brought responding to a book I had read some years earlier to strength.
Okay, it made me think of the book Why We Feel: The Science of Human Emotions by Victor Johnston.
In the book, Johnston describes the use of selection-based algorithms to produce a likeness of a person only briefly seen. Producing such a likeness is routinely performed in police investigations and is typically done by an observer describing facial characteristics to a graphic artist. Instead of this typical method, Johnston displayed on a computer screen various combinations of facial features. The observer then rated the characteristics and the face as to how well they matched the actual person observed. The algorithms generated variations, selected against variations that received low ratings, and presented new combinations based upon known variation principles. Within a short time, the algorithms provided a picture of the person that was a very close match to the person observed and was, in fact, much better than the artist's sketch.
The immediate question was raised: could a similar procedure be used to provide "a coherent picture of a person functioning highly competently…?" Of course, a questionnaire is based on asking questions, but so is an artist's sketch. Could a series of multiple choice or yes-no questions be used to generate an early picture—a written scenario—that could then have its features and overall description rated? As a result of interacting with the program, could a picture—much like what is derived from the Constructional Questionnaire—be accurately produced (as rated by the user)?
The Constructional Questionnaire begins:
"I am going to ask you a group of questions about your goals. You are here because you want certain changes to occur, or want something else. (a. Presented outcome) The first of these is: Assuming we were successful, what would the outcome be for you?"
At this point the client typically talks in generalities about being less anxious, depressed, etc. Or if more positive, "I would be a better communicator." The client is allowed to say whatever they like with little direction.
The next series brings much more specificity to the answers by asking what precisely the client would be doing if they were not anxious, depressed, etc. This is not always easy. People are used to speaking pathologically. That is, they can easily say what they would like to stop doing. But, describing what they would be doing if the present problem were not a problem can be challenging for many. To help with this, the next question was creatively designed to produce useful answers:
"Now, this may sound silly, but suppose one of these flying saucers is for real. It lands and 2,000 little Martians pour out. One of them is assigned to observe you—your name was chosen by their computer on some random basis. He lands some time after L-Day—Liberation Day from your problems—and follows you around invisibly. He records his observations and these are sent back to Mars. Their computer will decide on the basis of the sample of 2,000 Earthlings they have what their disposition toward Earth should be. What does he observe? (Alternate or added form: What would others observe when the successful outcome was obtained?)"
The client is then asked to begin in the morning and describe what the Martian sees from awaking in the morning to falling asleep at night, on weekdays and the weekend. Remember, this is life after the problems are solved. When a patient says, "I would have a happy exchange with the receptionist," the interviewer responds by saying, "What does the Martian see when you are having a happy exchange?" Eventually, a picture of how the client's life would change is provided. It is comprehensive and thorough and is likely something to which the client has given very little thought.
The next question asks, "How does this differ from the present state of affairs? Can you give me an example?" Here is where the client describes and gives examples of the difference between the way things are now and where they would be if all was well. It provides the before and after from which the success of the intervention will be determined.
Other questions are designed to explore other important areas, such as whether there is a "hidden agenda" not mentioned in the outcome question, what is going well and would not change, and one which often provides revealing answers: "You've heard of the proverb, 'It is an ill-wind that blows no good.' With regard to some advantages that might have 'blown your way,' has your problem ever produced any special advantages or considerations for you? (Examples: in school, job, at home) Please give specific examples." The full questionnaire may be seen here: http://journals.uic.edu/ojs/index.php/bsi/article/view/92/117.
Here was a method that had the potential to bring the benefits of this very sophisticated interview to thousands of people.
Two possibilities immediately emerged. First, could we ask some carefully constructed multiple choice type questions that would allow us to construct a completed scenario for the question about successful outcomes, which could then have its components as well as its overall picture rated? We could iterate this process using composite scenarios with the selectionist algorithms producing variants until the components and composite received high ratings for accuracy.
The second approach would be to take smaller steps. Instead of constructing a composite scenario and rating it's various components and the overall picture presented, this approach would present a component for rating. Once the component evolved into a highly rated one, another component would be added and the process repeated until a composite was produced. For example, "What would the Martian see when you awake, arrive at work, at lunch, etc.?" Mini scenarios would be generated and put through the process. Responses to earlier questions may be useful for producing subsequent variants. These components would eventually be put into a larger composite for evaluation.
Would one approach or the other yield better results? Would both yield the same result, but with one more efficient than the other? Could it be done at all? As to the last question, given my investigation into how Johnston contracted his algorithms, I was confident it actually would work. The accuracy of the scenarios could be evaluated using ratings as well as by comparing the results to verbal pictures produced during actual interviews. Once there was some confidence in the outcome, an evaluation could be conducted to determine how well programs whose outcomes were defined by this automated selectionist interview actually performed when used in a program to help individuals meet their goals.
Think about it for a minute. Here was a method that had the potential to bring the benefits of this very sophisticated interview to thousands of people. An interview that specifies not only the consequences maintaining the client's disturbing patterns given their alternatives, but that could specify outcomes having the same or better benefits at less cost to the individual. Further, it might be possible to produce different versions of the interview to match individual characteristics determined by a big data analysis. Earlier I described four possible categories into which potential uses might fall. Each person in a particular category could be provided with a separate interview customized for their category. Our research and development plan would need to coordinate these two features. Further, our individual assessment results would be fed back to the big data algorithms to help define and make more precise the categories and their predictive validity.
This would not simply be an app that provided goals and feedback, but one that evaluated progress, collected the right kind of information (including client emotions), adapted to user performance, benefitted from big data analytics, and would be able to switch from "topical" to "systemic" approaches to achieving client outcomes.
So now two elements of what would be required were specified: the big data feature and the selection-based automated interview based on the Constructional Questionnaire. But once the contingency analysis was made and a case guide such as described in Part 1 was generated, a delivery program would be required. This would not simply be an app that provided goals and feedback, but one that evaluated progress, collected the right kind of information (including client emotions), adapted to user performance, benefitted from big data analytics, and would be able to switch from "topical" to "systemic" approaches to achieving client outcomes.
Now an app would have to be created that could provide both topical and systemic programs, collect personal data, and connect everything to big data analytics and ongoing selection—the topic of Part 3.
T. V. Joe Layng has over 40 years of experience in the experimental and applied analysis of behavior with a particular focus on the design of teaching/learning environments. In 1999, he co-founded Headsprout. At Headsprout, Joe led the scientific team that developed the technology that forms the basis of the company's patented Early Reading and Reading Comprehension online reading programs, for which he was the chief architect. Joe earned a Ph.D. in Behavioral Science (biopsychology) at the University of Chicago where Israel Goldiamond was his advisor. At Chicago, working with pigeons, he investigated animal models of psychopathology, specifically the recurrence of pathological patterns (head-banging) as a function of normal behavioral processes. Joe also has extensive clinical behavior analysis experience with a focus on ambulatory schizophrenia especially the systemic as well as topical treatment of delusional speech and hallucinatory behavior. Joe is a fellow of the Association for Behavior Analysis International, and Chairman of the Board of Trustees, The Chicago School of Professional Psychology.


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- Premier League
Mourinho convinces Ba to stay
Demba Ba claims he will still be a Chelsea player next season after revealing Jose Mourinho has told him he wants the striker to stay.
Ba had said he wanted to leave in April because he felt he was not being given the opportunity to become a first-team regular at the club. Along with Chelsea's other strikers, he was also criticised by the manager for a lack of success in front of goal.
However, Ba, who joined from Newcastle United for £7 million in January 2013, says he will remain at Chelsea - even though he is not completely confident about getting more playing time.
"Jose Mourinho has asked me to stay at Chelsea next season," Ba told the Daily Star.
"He assured me that my situation would change. I see this as my reward from God. I weighed up the pros and cons and will stay put to see what happens.
"I don't know whether my situation will improve, but with the coach's offer anything can happen. I want to play a lot of matches and I think that will be the case for me."
Ba scored the decisive goal for Chelsea to help them overcome Paris Saint-Germain and reach the Champions League semi-finals. The Senegal international also scored the opening goal in the 2-0 victory against Liverpool at Anfield in the Premier League.
Ba was linked with a loan move to Arsenal last summer, but has revealed the reason why Mourinho decided to block the transfer.
"I was approached by Arsenal last August," he said. "But Mourinho refused to let me join them, as he said he didn't want to help a rival team to get stronger."
Chelsea finished third in the Premier League, four points behind champions Manchester City and, after losing to Atletico Madrid in the Champions League semi-finals, ended the season without a trophy.
Andre Schurrle says Mourinho - despite his protestations about making progress - was "not happy with the situation" and the German has called for his Chelsea team-mates to be "more ruthless" next term.
"We almost won two titles but in the end we finished with nothing," he said. "It all went wrong for us in one week. We drew at home to Norwich in the league and then we lost to Atletico Madrid in the Champions League.
"We lost the Premier League title because we didn't beat teams like Aston Villa, Sunderland and Crystal Palace.
"We won against all of our title rivals but we didn't play well against the lower teams. Next season we need to be much more ruthless - to be so strong that our opponents see they have no chance against us."


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When you quote something, or repeat an idea you got from somewhere else, you need to cite that source, so that other readers can easily find it. Historians use footnotes for citation. Other disciplines use other forms--for example, the name of the book at the date in parentheses. In this course you must use foot or end-notes. Footnotes appear at the bottom of the page; end-notes appear on a separate page at the end of the paper.
For quotations from print sources, the history department at George Mason uses the Turabian or Chicago style. You can purchase one of the style guides written by Kate Turabian at any bookstore. There is also a limited version of the Turabian guide on the web. This site includes standards for citing electronic sources, like CD-Roms or the internet.
Again, all quotations or restatements of other people's ideas or conclusions should be supported with citations in the Turabian style.
Guide to Citation


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Lufia II: Rise of the Sinistrals is a game I look back on fondly. It's kind of like one of your early crushes; you can't remember why or what attracted you to the person, you just remember that you liked them. That's exactly how Lufia II is for me. Not too much stands out in my mind as to why I loved it as much as I did; I just know I enjoyed the time I spent playing it. As such, I feel that it's my duty as a reviewer to let you know up front that my nostalgia meter might not be as high as the ultimate Lufia fanboy's or girl's. However, don't count me out of having nostalgic feelings altogether as I felt those twinges while I was playing Lufia: Curse of the Sinistrals (L:CotS) like a giddy little school girl. I must confess, though, I can't sit here and do a precise comparison of L: CotS to its SNES counterpart.
With that said, when I got an early glimpse of L:CotS at E3, I knew it was something special. I was hoping that feeling wasn't simply nostalgia with a short demo, because so many times when I hype myself for a game, I end up getting let down. Needless to say, I tried my hardest not to get my hopes up, but at the same time, I was secretly wishing that L:CotS would live up to the awesomeness of the E3 demo. After plowing through challenging time based puzzles that only the most hardcore Guitar Hero player would find easy and challenging boss battles that made me rethink my hardcore gamer status, I just have to say L:CotS is all kinds of awesome and then some. If you enjoy puzzles and exploration in the vein of Wild Arms and the Tales games with an old school feel, mark my words you don't want to pass up L:CotS. Natsume and Neverland deserve a round of applause for bringing hardcore RPG fans such a worthy game to add to their collection.
Oh No! Gades: The Sinistral of Destruction is Approaching!
L:CotS starts with Gades, "The Sinistral of Destruction," wreaking havoc upon the world. Maxim, the monster-hunting main character, runs into Gades and they duel. Gades realizes Maxim has a strong power, but is still not strong enough to defeat him. From here on out, Maxim is on a journey to find Gades again while strengthening himself enough to take the foul being down for good. During this journey, Maxim meets up with other characters who help him in his quest to bring ultimate peace to the world. Like most other RPGs, the quest is not only about Gades. There are also other bad guys along the way who derail the gang's progress as they try to inch closer to Gades.
The story itself is a complete reimagining of Lufia II: Rise of the Sinistrals. The script was reworked from the ground up, so Natsume had a lot of localizing to do. With that said, I wouldn't call the story the main focus of the game (and most Lufia fans wouldn't disagree with me here). It really isn't anything to write home about and, to be honest, it's really bare bones throughout. There are scenes here and there as you complete dungeons, but something feels a little disjointed about them and how they function in the whole scheme of the story. I will say that Natsume, for the most part, did an excellent job with the localization of this game. It's obvious they put a lot of effort into it and it's free of spelling and grammar errors. My only gripe is the humor in this game. There are some funny moments, but a lot of it seems like the game is trying too hard to be funny in an obvious way. L:CotS almost feels like that kid at the party who keeps telling all the jokes you've heard before; you'll laugh at the first few, but then after a while you've had your fill. I'll admit, I had more than a few eye roll moments. On the other side of the coin, it is nice to have an RPG not take itself too seriously, so if you want an RPG that takes the whole "we need to save the world" thing with some levity and where your characters have some fun along the way, L:CotS may be your cup of tea.
I also wouldn't go into L:CotS expecting to become attached to the characters. Regrettably, the cast didn't resonate as much with me as I hoped they would. I'm all about strong characters in my games, so this was disappointing. Perhaps it was the game's focus on having such one dimensional characters; every character seems to have one big trait and that's all there is to them. For instance, Tia is insecure because she has feelings for Maxim and Guy is not the sharpest crayon in the box, but outside of those traits – I'm not sure I could tell you much more about these characters personality wise. One character who managed to be more multi-dimensional was Selan. I won't say why, as I don't want spoil anything, but she had more layers than the supporting cast. I would have liked a little more depth to the other characters, but at the end of the day what shines best about L:CotS is the gameplay, which kept me playing the game. And I think it says a lot that I was so enamored with that aspect of the game that the story and characters didn't weigh on me as much as they usually do when I play RPGs.
Puzzles and Bosses That Will Boggle Your Mind
The gameplay recipe in L:CotS is one part puzzle solving and one part dungeon crawling. Most old school Lufia II fans know the biggest change in L:CotS is the battle system. L:CotS scrapped the traditional battle system that Lufia II used in favor of an action-based battle system. Thankfully, the game also lacks random battles; you can actually see what you are getting yourself into. For the most part, the new and improved battle system works well. It makes sense, because you're exploring the atmosphere and solving puzzles. If the traditional battle system was still in place, it wouldn't have worked so well since the separate battle screens would wreck the flow of the dungeon. Trust me on this, it was bad enough enemies respawned a few times before they completely stopped, making puzzle completion a pain. I�m pretty sure if you added random battles to the equation, I wouldn't have been able to handle it.
The only problem that I had with the new battle system was more with the controls and camera angles than with the system itself. The controls lack fluidity and it feels a little clunky to say the least. I never felt like the actions went smoothly and it was difficult at times to get used to the Y as the action button instead of the usual A. Camera angles can get tricky as well, as since environments sometimes get in your way. I noticed this more when I was making jumps for puzzles, but it's still sometimes obstructive to the player. This isn't anything new to using an action based battle system. Anybody who has played Kingdom Hearts can tell you that camera angles are the number one gripe they have with the game. It's just a shame that the controls aren't as fluid as they could be.
As you explore dungeons, you'll run the gamut of standard RPG staples: you'll fight enemies, level up, and get new gear. The armor and weapons you purchase increase your stats and some weapons even net you additional abilities in battles. Standard battles can be difficult in L:CotS and it seems like the game forces the player to always be prepared. Almost any status ailment that can hit you will hit you. In L: CotS, there are very few times that you are lucky. Limited inventory space doesn't help combat this issue: you can only carry nine of each item at a time, so those of you who try to bulk up on items as a strategy need to think of a different one. Yes, this game is not for the feint of heart.
Boss battles are just as intense and are quite varied. That's probably where this game stands out: you're never in the same boss battle and always possess some new strategy to net a win. Whether it's throwing a bomb at just the right time to blow up a tank or destroying several towers as an evil Sinistral jumps from one to another, there's never a dull moment in a boss battle. One thing is always consistent, they are never easy. In fact, the game even knows this because it has a feature where, for no penalty, you can choose to raise all your characters five levels and try the battle again if you fall. Honestly, using it doesn't make the game that much easier, either. That just goes to show where this game lies on the difficultly meter.
Another way to remedy the toughness of the game is to take advantage of the Mystic Stone Board. Using the Mystic Stone Board, you can customize your characters a bit by giving them certain stat boosts as you see fit. Each character has their own board that you can connect the stones together on. The key is that all the stones must be connected to one another to be activated. It's another part of the game that is almost like a puzzle to figure out, you want to strategize what is best to do with your stones, i.e. what will get you the most bang for your buck and to split them accordingly between your party members. It's not the most complicated character customization system, but it works for what it is.
Besides tough as nails boss battles, as you explore dungeons you'll experience another type of toughness &ndash this time for your head: puzzles. Now, none of the puzzles are too difficult, but they do require some brain power. The majority of the time when I was stuck on a puzzle, I would go back and realize how to figure it out and feel ashamed that I hadn't thought of the solution sooner. A nifty feature of L:CotS is that each character has their own unique ability to help you solve puzzles. For instance, Selan has a boomerang that can activate far away switches while Guy can crush large boulders that stand in your way. Often during dungeons, you switch back and forth between characters to complete the puzzles. The best part of the puzzles in this game is that they aren't redundant and don't rely on similar solutions to advance. There's a good amount of challenge here where you'll have to think outside of the box. There are also time based puzzles as well, which require some extra skill. Some of the dungeons you'll have to revisit during your journey, but the puzzles you have to complete to advance in them will always change. And, thankfully, if you mess up a puzzle there is a reset button to start you up at your last checkpoint. My only complaint is the lack of a save anywhere feature. They really should be obligatory in handheld games, especially when trying to solve a puzzle you can't figure out. I had to keep my DS on sleep mode on the charger a lot just to ensure I didn't lose any of my data.
I must confess, the best part of L:CotS is the variety within the game. This could have been a very generic game relying on nostalgia alone, but it has so much jam packed into it that it never got dull for me. And, yes, long time fans, the Ancient Cave is even there for you. For those of you who don't know what the Ancient Cave is, you start back to level one and lose all your equipment and basically have to dungeon crawl your way back up to the top and regain all your equipment. If you leave the cave you lose your progress. It's intense, but a fun challenge at the same. Back to my point, there is something for everyone in this game. Heck, at one point, I even got to control a tank. I wasn't expecting so much out of the gameplay, but it truly was a treat to play a game that constantly changed things up as I played it. Things never got boring and I always felt a challenge with L:CotS. The gameplay truly is what makes this game stand out.
A Facelift and Familiar Sounds
L: CotS features brand new 3D character models and in-game character portraits. The newer character models do look better than they did in Lufia II: Rise of the Sinistrals, and yet compared to what's out in the market today, they don't stand out too much. The 3D graphics are a nice addition and do give it an up to date feel, but sometimes they do appear pixilated on the DS screen. Each dungeon stands out from the other, but within any given dungeon there isn't much that separates one area from the next. Unfortunately, that's disheartening because you have to revisit some of the dungeons in the game.
Hardcore Lufia fans might recognize some of the tunes in L: CotS; some tracks from Lufia II: Rise of the Sinistrals have been rearranged. This no doubt keeps the nostalgia flowing as you're playing the game. In fact, the soundtrack has such a great way of pumping you up for battle and keeping your ear in tune throughout the game. This is quite a sanity saver when "battling" a difficult puzzle. Something that's completely new for Lufia fans is voice acting. It's not the best I've heard, but it's not terrible. It's adequate and it supplements the game like it's supposed to. I've always seen voice acting as just a bonus and not an end all be all, so that's how I view it here.
One of the Better Offerings On Your DS
Lufia: Curse of the Sinistrals may fall short in a few areas, but it more than makes up for it in its dynamic gameplay. For a reimagining of a classic, this game sure does get it right; it does just enough new while preserving just enough of what people loved about Lufia II: Rise of the Sinistrals. The most impressive part of Lufia: Curse of the Sinistrals is the amount of variety packed into its gameplay, there really is something new with every dungeon, puzzle, and boss battle you encounter. There's something here for the hardcore Lufia fan and the RPG fan who has never played a Lufia game. There's really no excuse not to experience one of the better games to hit the DS this year.
May 19: Zanki Zero: Last Beginning w/Scott • 10am PDT/1pm EDT
Suikoden II w/Maxx • 12pm PDT/3pm EDT
Golden Sun w/Kat • 4pm PDT/7pm EDT
Final Fantasy VIII w/Kyle • 3pm PDT/6pm EDT
Valkyrie Profile 2 w/Scott • 7pm PDT/10pm EDT
Mass Effect 2 w/Nathan • 10am PDT/1pm EDT
Valkyrie Profile 2 w/Scott • 7pm PDT/10pm EDT
Golden Sun w/Kat • 4pm PDT/7pm EDT
Valkyrie Profile 2 w/Scott • 7pm PDT/10pm EDT
Super Robot Wars X w/Kyle • 3pm PDT/6pm EDT
Trails of Cold Steel (Nightmare Mode) w/Scott • 7pm PDT/10pm EDT
Final Fantasy XIV Online w/Scott • 3pm PDT/6pm EDT


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|Add Memory | Add To Friends
|moonshinehommie (profile) wrote,
on 11-18-2007 at 10:50pm
|Subject: im hurt
|Briana finally wrote me back...it was the worst thing that happened to me all week.
Looking back on life in High school I really don't blame her for being a total bitch to me but what she said to me was harsh. she even made me cry. I have never understood that words hurt untill just a min ago. I don't think anybodys letter has ever made me cry before.
I guess that just tops off my week though. I have been working my ass off lately to reap no benifit from it. it seems as soon as I get any money it leaves my pocket almost as soon as it enters it. something always comes up. Like the fact that I have already paid corey for my insurance this month but so simply "forgot" about it and spent the money so now I have to pay it again so that I am not driving around without insurance. Oh and my car payment and phone bill...I just can't keep up I don't make enough money to be paying for two people right now. I don't know what to do there are no good jobs around here and seems that ever single interview that I go on is just a joke. I am so frustrated right now. Maybe I need to get another part time job. Then I really wouldn't have any spare time.
Jessa and Andy) I had a great time this weekend and believe it or not so did corey! it helped hanging out with some friends for once this week it made my day at work today go a lot more smoother. Thanks . And we should deffiently do that again next weekend.
well okay I should probably calm down and take a bath or something Im stressed....maybe some tea? hmm that sounds good
|Read Comments


text:
DAVISON, Hollis
DAVISON, Hollis, General USMC. Inspector General for the Marine Corps arrived at ET AFB to investigate supposed misuse of military aircraft by Col. Underwood. He was assigned additional duties as the Deputy Naval Inspector General for Marine Corps Matters Inspector/General of the Marine Corps on Oct 1, 1990. General Davison retired from active duty on January 1, 1992.


text:
1. Rose, B.R., Thompson, C.E., McDonald, A.M., Henderson, B.R., Cossart, Y.E. and Morris, B.J. (1987) Cell biology of cultured lesions.
Br. J. Dermatology , 116, 311-322.
2. Parker, B.J., Cossart, Y.E., Thompson, C.H., Rose, B.R. and Henderson, B.R. (1987) The clinical management and laboratory assessment of lesions.
Med. J. Aust ., 147, 59-63.
3. Henderson, B.R., Thompson, C.H., Rose, B.R., Cossart, Y.E. and Morris, B.J. (1987) Detection of specific types of human papillomavirus by DNA hybridisation.
J. Medical Virology , 21, 381-393.
4. Chee, M.S., Rizos, H., Henderson, B.R., Baker, R. and Stewart, T.S. (1991) Subfamilies of serine tRNA genes in the bovine genome.
Mol. Gen. Genet., 231, 106-112.
5. Henderson, B.R. and Kefford, R.F. (1991) Conservation and potential role of RNA-instability motifs in urokinase gene 3'-untranslated sequences.
J. Natl. Cancer Inst., 83, 1103-1104.
Henderson, B.R.,
McDonald, D.A. and Kefford, R.F. (1992) Post-transcriptional regulation of
urokinase plasminogen activator gene expression occurs in the
nucleus of BC1 rat mammary cells.
Int. J. Cancer, 50, 918-923.
Henderson, B.R.,
Tansey, W.P., Phillips, S.M., Ramshaw, I.A. and Kefford, R.F. (1992)
Transcriptional and posttranscriptional activation of urokinase plasminogen
activator gene expression in metastatic tumor cells.
Cancer Res., 52, 2489-2496.
Henderson, B.R. and
Sleigh, M.J. (1992) TATA box-independent transcription of the human tissue
plasminogen activator gene initiates within a sequence conserved
in related genes.
FEBS Lett., 309, 130-134.
9. Henderson, B.R. and Kefford, R.F. (1993) Dexamethasone decreases urokinase plasminogen activator mRNA stability in MAT 13762 rat mammary carcinoma cells.
Br. J. Cancer, 67, 99-101.
10. Henderson, B.R. (1993) Expression of the nm23-2/NDP kinase alpha gene in rat mammary and oral carcinomas of varying metastatic potential.
Br. J. Cancer, 68, 874-878.
Emery-Goodman, A., Hirling,
H., Scarpellino, L., Henderson, B. and Kühn, L.C. (1993) Iron regulatory
factor expressed from recombinant baculovirus: conversion
between the RNA-binding apoprotein and Fe-S cluster containing aconitase.
Nuc. Acids Res., 21, 1457-1461.
12. Henderson, B.R., Seiser, C. and Kühn, L.C. (1993) Characterization of a second RNA-binding protein in rodents with specificity for iron-responsive elements.
J. Biol. Chem., 268, 27327-27334.
Hirling, H., Henderson,
B.R. and Kühn, L.C. (1994) Mutational analysis of the [4Fe-4S]-cluster
converting iron regulatory factor from its RNA-binding form to
cytoplasmic aconitase.
Henderson, B.R.,
Menotti, E., Bonnard, C. and Kühn, L.C. (1994) Optimal sequence and structure
of iron-responsive elements: Selection of RNA stem-loops with
high affinity for iron regulatory factor.
J. Biol. Chem., 269, 17481-17489.
15. Kuhn, L.C., Hirling, H., Henderson, B., Emery-Goodman, A., Neupert, B. and Kaldy, P. (1994) The structure of iron regulatory factor.
Adv. Exp. Med. Biol. 356, 101-109.
16. Henderson, B.R., McDonald, D., Jones, S. and Kefford, R.F. (1995) A novel model for metastasis suppression involving regulation of nuclear precursor mRNA stability.
Int. J. Oncology, 6, 483-486.
Henderson, B.R. and
Kühn, L.C. (1995)
modulation of the RNA-binding proteins IRP-1 and IRP-2 in response to iron:
IRP-2 inactivation requires
translation of another protein.
J. Biol. Chem., 270, 20509-20515
Kohler, S.A., Henderson,
B.R. and Kühn, L.C. (1995) Succinate dehydrogenase b mRNA of drosophila
melanogaster has a functional iron responsive element in its 5'
untranslated region.
J. Biol. Chem., 270, 30781-30786
19. Henderson, B.R., Menotti, E.M. and Kühn, L.C. (1996) Iron regulatory proteins 1 and 2 bind distinct sets of RNA target sequences.
J. Biol. Chem., 271, 4900-4908
Henderson, B.R. and
Percipalle, P. (1997) Interactions between HIV Rev and nuclear import and
export factors: The Rev nuclear localisation signal mediates specific
binding to human importin-beta
J. Mol. Biol., 274, 693-707.
21. Menotti, E.M., Henderson, B.R. and Kuhn, L.C. (1998) Translational regulation of mRNAs with distinct IRE sequences by Iron Regulatory Proteins 1 and 2.
J. Biol. Chem., 273, 1821-1824.
22. Henderson, B.R. and Eleftheriou, A. (2000) A comparison of the activity, sequence specificity and CRM1-dependence of different nuclear export signals.
Exp. Cell Res., 256,213-224.
23. Henderson, B. R . (2000) Nuclear-cytoplasmic shuttling of APC regulates beta-catenin sub-cellular localization and turnover.
Nature Cell Biology, 2, 653-660.
24. Rodriguez, J. and Henderson, B.R. (2000) Identification of a functional nuclear export sequence in the BRCA1 tumor suppressor.
J. Biol. Chem., 275, 38589-38596.
25. Eleftheriou, A., Yoshida, M. and Henderson, B.R. (2001) Nuclear export of human beta-catenin can occur independent of CRM1 and the APC tumor suppressor.
J. Biol. Chem., 276, 25883-25888.
26. Lixin, R., Efthymiadis, A., Henderson, B. and Jans, D.A. (2001) Novel properties of the nucleolar targeting signal of angiogenin.
Biochem. Biophys. Res. Comm., 284, 185-193.
27. Lam, M.H.C., Henderson, B., Gillespie, M.T. and Jans, D.A. (2001) Dynamics of leptomycin B-sensitive nucleocytoplasmic flux of parathyroid hormone-related protein.
Traffic, 2, 812-819.
Galea, M.A., Eleftheriou,
A. and Henderson, B.R. (2001) ARM domain-dependent nuclear import of APC
is stimulated by the B56alpha sub-unit of protein
phosphatase 2A.
J. Biol. Chem., 276, 45833-45839.
Fabbro, M., Rodriguez,
J.A., Baer, R. and Henderson, B.R. (2002) BARD1 induces BRCA1
intranuclear foci formation by increasing RING-dependent BRCA1 nuclear
import and inhibiting BRCA1 nuclear export.
J. Biol. Chem., 277, 21315-21324.
30. Henderson, B.R., Galea, M.A., Schuechner, S. and Leung, L. (2002) LEF-1 blocks APC-mediated nuclear export and degradation of beta-catenin.
J. Biol. Chem., 277, 24258-24264.
Keough, R.A.,
Macmillan, E.M., Luwyche, J.K., Gardner, J.M., Tavner, F.J., Jans, D.A., Henderson,
B.R. and Gonda, T.J. (2003) Myb-binding protein 1a is a
nucleocytoplasmic shuttling protein that utilizes CRM1-dependent and -independent nuclear export pathways.
Exp. Cell Res., 289, 108-123.
32. Fabbro, M., Schuechner, S., Au, W.W. and Henderson, B.R. (2004) BARD-1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention.
Exp. Cell Res. 298,
Rodriguez, J.A., Schuechner, S., Au, W.W.Y., Fabbro, M. and Henderson,
B.R. (2004) Nuclear-cytoplasmic shuttling of BARD1 contributes to its
pro-apoptotic activity
and is regulated by dimerization with BRCA1.
Oncogene 23, 1809-1820.
34. Rodriguez, J.A., Au, W.W.Y. and Henderson, B.R. (2004) Cytoplasmic mislocalization of BRCA1 caused by cancer-associated mutations in the BRCT domain.
Exp. Cell Res. 293, 14-21.
35. Au, W.W.Y. and Henderson, B.R. (2005) The BRCA1 RING and BRCT domains cooperate in targeting BRCA1 to ionizing radiation-induced nuclear foci.
J. Biol. Chem. 280, 6993-7001.
36. Brocardo, M., Näthke, I. and Henderson, B.R. (2005) Redefining the subcellular location and transport of APC: novel insights using a panel of antibodies.
EMBO Reports 6, 184-190.
37. Schüchner, S., Tembe, V., Rodriguez, J.A. and Henderson, B.R. (2005) Nuclear targeting and cell cycle regulatory function of human BARD1.
J. Biol. Chem. 280, 8855-8861.
Lovelock, P., Healey, S.,
Wendy Au, Eleanor Sum, Ee Ming Wong, Andrea Tesoriero, Ross Brinkworth, Anna
Bekessy, Orland Diez, Mark Jenkins, Helene Renard,
John Hopper, Paul Waring,
kConFab, Sean Tavtigian, David Goldgar, Geoff Lindeman, Jane Visvader, Fergus
Couch, Beric Henderson, Melissa Southey,
Georgia Chenevix-Trench, Amanda Spurdle, Melissa Brown (2006) BRCA1 variant 1708E is mislocalised to the cytoplasm of human cells in vitro and is associated with
centrosome amplification.
J. Med. Genetics 43, 74-83.
Sharma, M., Leung, L.,
Brocardo, M., Henderson, J., Flegg, C. and Henderson, B. R. (2006)
Membrane localization of adenomatous polyposis coli protein at cellular
protrusions: Targeting sequences and regulation by beta-catenin.
J. Biol. Chem 281, 17140-17149.
Sharma, M. and Henderson,
B.R. (2007) IQGAP1 regulates beta-catenin at membrane ruffles and its role
in macropinocytosis of N-cadherin and adenomatous
polyposis coli.
J. Biol. Chem. 282, 8545-8556 .
41. Au, W.W.Y. and Henderson, B.R. (2007) Identification of sequences that target BRCA1 to nuclear foci following alkylative DNA damage.
Cellular Signalling 19, 1879-1892
42. Zanella, F., Rosada, A., Blanco, F., Henderson, B.R., Carnero, A. and Link, W. (2007) A HTS approach to screen for antagonists of the nuclear export machinery using
high content cell based assays.
Assay and Drug Development Technologies 5, 333-342
Bolli, N.,
Nicoletti, I., Felicetta De Marco, M., Bigerna, B., Pucciarini, A., Mannucci,
R., Paola Martelli, M., Liso, A., Mecucci, C., Fabbiano, F., Martelli, M.F., Henderson,
and Falini, B. (2007) Born to be exported: C-terminus nuclear export signals of different strength ensure cytoplasmic accumulation of nucleophosmin leukemic mutants.
Cancer Research 67, 6230-6237
V. and Henderson, B.R. (2007)
BARD1 translocation to mitochondria
correlates with Bax oligomerization, loss of mitochondrial membrane potential
J. Biol. Chem. 282, 20513-20522
Lovelock, P.K., Spurdle,
A.B., Mok, M.T.S., Farrugia, D.J., Lakhani, S.R., Healey, S., Arnold, S.,
Buchanan, D., kConFab,
Couch, F.J., Henderson,
B.R., Goldgar, D.E.,
Tavtigian, S., Chenevix-Trench, G. and Brown, M.A.
Identification of BRCA1 missense
substitutions that confer partial functional activity: potential
moderate risk variants?
Breast Cancer Research, 9:R82
Brocardo, M., Lei, Y.,
Tighe, A., Taylor, S.S., Mok, M.T. and Henderson, B.R. (2008)
Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by
truncating cancer mutations: Regulation of Bcl-2 and implications for cell survival
J. Biol. Chem. 283, 5950-5959
47. Fabbro, M. and Henderson, B.R. (2008) BARD1 regulates BRCA1-mediated transactivation of the p21WAF1/CIP1 and Gadd45 promoters.
Cancer Letters 263, 189-196
Johnson, M., Sharma, M.,
Jamieson, C., Henderson, J.M., Mok, M.T.S., Bendall, L. and Henderson, B.R.
(2009) Regulation of beta-catenin trafficking to the membrane in
living cells.
Cellular Signalling
21, 339-348
Maniccia, A.W., Lewis, C.,
Begum, N., Xu, J., Cui, J., Chipitsyna, G., Aysola, K., Reddy, V., Bhat, G.,
Fujimura, Y., Henderson, B., Reddy, E.S.P and Rao, V.N. (2009)
Mitochondrial localization, ELK-1 transcriptional regulation and growth inhibitory functions of BRCA1, BRCA1a and BRCA1b proteins.
J. Cell. Physiol 219, 634-641
Zheng, G., Lyons G.J, Wang,
Y., Tang, T.K., Min, D., Coombes, J., Rangan, G.K., Hu, M., Henderson, B.R.,
Alexander, S.I. and Harris, D.C.H. (2009)
Disruption of E-cadherin
By Matrix Metalloproteinase Directly Mediates Tubular Epithelial-Mesenchymal Transition Downstream of TGF- b 1.
Am. J. Physiol. 175, 580-591
51. Mok, M.T.S. and Henderson, B.R. (2010) A comparison of BRCA1 nuclear localization with 14 DNA damage response proteins and domains: identification of specific
differences between BRCA1 and 53BP1 at DNA damage-induced foci.
Cellular Signalling 22, 47-56
52. Brodie, K. and Henderson, B.R. (2010) Differential modulation of BRCA1 and BARD1 nuclear localisation and foci assembly by DNA damage.
Cellular Signalling 22, 291-302
C., Sharma, M., Medina-Palazon, C., Jamieson, C., Galea, M., Brocardo, M.,
Mills, K. and Henderson, B.R. (2010) Nuclear export and centrosome
targeting of
the protein phosphatase 2A subunit B56alpha: Role of B56alpha in nuclear export of the catalytic subunit.
J. Biol. Chem. 285, 18144-18154
54. Johnson, M.J., Sharma, M., Brocardo, M.G. and Henderson, B.R. (2011) IQGAP1 translocates to the nucleus in early S-phase and contributes to cell cycle progression
after DNA replication arrest
Int. J. Biochem and Cell Biol. 43, 65-73.
55. Jamieson, C., Sharma, M and Henderson, B.R. (2011) Regulation of beta-catenin nuclear dynamics by GSK-3beta involves a LEF-1 positive feedback loop.
Traffic 12, 983-999
56. Brocardo, M.G., Borowiec, J. and Henderson, B.R. (2011) Adenomatous polyposis coli protein regulates the cellular response to DNA replication stress.
Int. J. Biochem and Cell Biol. 43, 1354-1364
K., Mok, M.T.S. and Henderson, B.R. (2012) Characterization of BARD1
targeting and dynamics at the centrosome: The role of CRM1, BRCA1 and the
Q564H mutation.
Cellular Signalling 24, 451-459
58. Mok, M.T.S. and Henderson B.R. (2012) A two-step FACS approach to isolate genetically modified mammalian cells with IPTG-inducible gene expression.
Cytometry 81, 101-104
K. and Henderson, B.R. (2012)
Characterization of BRCA1 centrosome
targeting, dynamics and function: A role for the nuclear export signal, CRM1
Aurora A kinase.
J. Biol. Chem 287, 7701-7716
60. Mok, M.T.S. and Henderson, B.R. (2012) The in vivo dynamic organization of BRCA1-A complex proteins at DNA damage-induced nuclear foci.
Traffic 13, 800-814
Mok, M.T.S. and Henderson,
B.R. (2012) Three-dimensional imaging reveals the spatial separation of
gammaH2AX-MDC1-53BP1 and RNF8-RNF168-BRCA1-A
complexes at ionizing radiation-induced foci.
Radiotherapy and Oncology 103, 415-420
62. Mok, M.T.S. and Henderson, B.R. (2012) The in vivo dynamic interplay of MDC1 and 53BP1 at DNA damage-induced nuclear foci.
Int. J. Biochem and Cell Biol . 44, 1398-1409
M. and Henderson, B.R. (2012) The scaffolding protein IQGAP1 co-localises
with actin at the cytoplasmic face of the nuclear envelope: implications for
cytoskeletal regulation.
Bioarchitecture 2, 138-142
Johnson, M., Sharma, M., Mok, M.T. and Henderson,
B.R. (2013) Stimulation of in vivo nuclear transport dynamics of actin and
its co-factors IQGAP1 and Rac1 in
response to DNA replication stress.
BBA Mol Cell Res. 1833, 2334-2347
Y., Henderson, B.R., Emmanuel, C., Harnett , P. and DeFazio, A. (2015)
Inhibition of ANKRD1 sensitizes human ovarian cancer cells to endoplasmic
stress-induced apoptosis.
Oncogene 34, 485-495 (IF= 8.56)
E., Henderson, B.R. and Brocardo, M.G. (2014)
Targeting the DNA
replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy
to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy.
Oncotargets 5, 9889-9990
67. Mok, M.T.S., Cheng, A.S.L. and Henderson, B.R. (2014) The ubiquitin ligases RNF8 and RNF168 display rapid but distinct dynamics at DNA repair foci in living cells.
Int. J. Biochem. Cell Biol. 57, 27-34
S.C., Garcia, M. I., Wagner II, L.E., Rodriguez, A.M., Chintapalli, S.V.,
Snyder, R.R., Hankins, G.D.V., Henderson, B.R., Brodie, K.M., Yule,
D.I., van Rossum,
D.B. and Boehning, D. (2015) The BRCA1 tumor suppressor binds to Inositol 1,4,5-Trisphosphate receptors to stimulate apoptotic calcium release.
J. Biol. Chem 290, 7304-7313
V., Martino-Echarri, E, Marzec, K.A., Mok, M.T.S., Brodie, K.M.,
Mills, K., Lei, Y., DeFazio, A., Rizos, H., Kettle, E., Boadle, R. and Henderson,
BARD1 BRCT domain contributes to p53 binding, cytoplasmic and mitochondrial localization, and apoptotic function.
Cellular Signalling 27, 1763-1771
Jamieson, C., Lui, C., Brocardo, M.G. and Henderson,
B.R. (2015) Rac1 augments Wnt signaling by stimulating beta-catenin-LEF-1
complex assembly independent of
beta-catenin nuclear import.
J. Cell Sci 128, 3933-3946
71. Lui, C., Ashton, C., Sharma, M, Brocardo, M.G. and Henderson, B.R. (2016) APC functions at the centrosome to stimulate microtubule growth.
Int. J. Biochem and Cell Biol . 70, 39-47
72. Mills, K., Brocardo, M.G. and Henderson, B.R. (2016) APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane.
Molecular Biology of the Cell 27, 466-482 (highlighted by the editors)
73. Jamieson, C., Mills, K.M., Lui, C., Semaan, C., Molloy, M.P., Sharma, M., Forwood, J.K. and Henderson, B.R . (2016) Characterisation of a beta-catenin nuclear
localisation defect in MCF-7 breast cancer cells.
Exp Cell Res. 341, 196-206.
74. Martino-Echarri, E., Brocardo, M.G., Mills, K.M. and Henderson, B,R . (2016) Tankyrase inhibitors stimulate the ability of tankyrases to bind axin and drive assembly
of beta-catenin degradation competent axin puncta.
PLoS One 11(3):e0150484.
75. Lui, C., Mok, M.T. and Henderson, B.R . (2016) Characterisation of adenomatous polyposis coli protein dynamics and localisation at the centrosome.
Cancers (Basel) 8(5). pii: E47
76. Marzec, K.A., Martino-Echarri, E., Irminger-Finger, I. and Henderson, B.R . (2016) BARD1 splice variants display mislocalisation in breast cancer cells and can alter the
apoptotic response to cisplatin.
Cancer Letters 2016 381(1):149-155
77. Sharma, M., Jamieson, C., Lui, C., Henderson, B.R . (2016) Distinct hydrophobic "patches" in the N- and C-tails of beta-catenin contribute to nuclear transport.
Exp. Cell Res. 348(2):132-145
Dickson, K.A., Cole, A.J., Gill, A.J.,
Clarkson, A., Gard, G.B., Chou, A., Kennedy, C.J.,
Henderson, B.R
., Australian Ovarian Cancer Study
(AOCS), Fereday, S.,
Traficante, N., Alsop, K., Bowtell, D.D., DeFazio, A.,
Clifton-Bligh, R., Marsh, D.J. (2016) The RING finger domain E3 ubiquitin ligases BRCA1 and the RNF20/RNF40
complex in global loss of the chromatin mark histone H2B monoubiquitination (H2Bub1) in cell line models and primary high-grade serous ovarian cancer.Hum. Mol. Genet . 25(24):5460-5471.
Invited Review Articles
79. Henderson, B.R. (1996) Iron Regulatory Proteins 1 and 2.
BioEssays 18, 39-46
80. Henderson, B.R. and Fagotto, F. (2002) The ins and outs of APC and beta-catenin nuclear transport.
EMBO Reports, 3, 834-839.
81. Fabbro, M. and Henderson, B.R. (2003) Regulation of tumor suppressor proteins by nuclear-cytoplasmic shuttling.
Exp. Cell Res. 282, 59-69
82. Henderson, B.R. (2003) Nuclear transport as a target for cancer therapies.
Drug Discovery Today, 8, 249. Invited Commentary.
83. Henderson, B.R. (2005) Regulation of BRCA1, BRCA2 and BARD1 intracellular trafficking.
Bioessays 27, 884-893.
84. Tembe, V. and Henderson, B.R. (2007) Protein localisation response to DNA damage.
Cellular Signalling 19, 1113-1120.
85. Brocardo, M. and Henderson, B.R. (2008) Shuttling of APC to the membrane, nucleus and beyond.
Trends in Cell Biology 18, 587-596.
86. Johnson, M., Sharma, M. and Henderson, B.R. (2009) IQGAP1 regulation and roles in cancer.
Cellular Signalling 21, 1471-1478
87. Henderson, B.R. (2010) Cryptic mitochondrial targeting signals in human ARF: clues to controlling cancer?
Cell Cycle 9, 866-867
C., Mills, K., Brocardo, M.G., Sharma, M. and Henderson, B.R. (2012) APC
as a mobile scaffold: Regulation and function at the nucleus, centrosomes and
IUBMB Life 64, 209-214.
89. Jamieson, C., Sharma, M. and Henderson, B.R. (2012) Wnt Signaling from membrane to nucleus: beta-catenin caught in a loop.
Int. J. Biochem and Cell Biol. 44, 847-850
90. Henderson, B.R. (2012) BRCA1 intracellular dynamics, transport and function.
Scientifica 1-15
91. Jamieson, C., Sharma, M. and Henderson, B.R. (2014) Targeting the beta-catenin nuclear transport pathway in cancer.
Sem. Cancer Biol . 27, 20-29.
Invited Book Chapters
92. Henderson, B.R. and Kühn, L.C. (1997) Interaction between Iron Regulatory Proteins and their RNA target sequences, Iron-Responsive Elements.
In "Cytoplasmic fate of messenger RNA" (Ph. Jeanteur, ed.)
Progress in Molecular and Subcellular Biology Vol. 18, Springer-Verlag Berlin Heidelberg, pp. 117-139
93. Henderson, B.R. (1999) Post-transcriptional regulation. In
Encyclopedia of Molecular Biology (T. Creighton, ed.) John Wiley & Sons, New York, pp.1927-1931
94. Brocardo, M. and Henderson, BR (2008) "Detection of cytoplasmic and nuclear localisation of adenomatous polyposis coli (APC) protein in cells " in Wnt Signaling.
Methods in Molecular Biology (E. Vincan ed., Humana Press NY) Volume 468, pp. 77-89.
M. and Henderson, B.R. (2010) "Methods to measure the nuclear export of
beta-catenin using fixed cell and live cell assays" in "Transcription
Methods and Protocols"
Methods in Molecular Biology (P. Higgins ed., Humana Press NY) Volume 647, pp. 187-197
Sharma, M.,
Johnson, M., Brocardo, M., Jamieson, C. and Henderson, B.R. (2014) "
Wnt signalling proteins associate with the
nuclear pore complex: Implications
for cancer" in " Cancer biology and the nuclear envelope"Advances in Experimental Medicine, 773, 353-372


text:
Coronado football success started at Holmes Middle School
He didn't realize at the time what an understatement that would be.
In the recently completed football season, almost the entire Coronado team consisted of boys who played their first organized tackle football at Holmes, including seniors who were seventh-graders on that 2008 team.
It's hard to dispute the difference the program has made. Until 2012, when Coronado went 5-5, the high school had been below .500 every season since 1992, and this year was the Cougars' best ever at 13-1.
Spectators applauding senior Joah Smith's long passes to his twin brother Sam - including a key fourth-quarter play in the title contest - could have seen a preview of that in middle school. "We were able to put Joah back at quarterback, and we had one little play where it was almost a touchdown every time," Wilshusen recalled. "When I saw the games this year, I remembered that."
Some of this year's Coronado players have even kept the jersey numbers they were assigned in middle school, noted Mike Kreidel, who shares the Holmes head- coach duties with Wilshusen in alternating years. These include Zeb Foster (44), Austin Micci (33) and Isaah Duvall (42).
The way the program works, Holmes and other middle schools coordinate with City Parks' youth sports division. Before 2008, kids who signed up with Parks would be assigned to random teams. What changed that year was that middle schools could have their own teams, taking the seventh- and eighth-graders from their attendance areas.
(Initially, on the Westside, West Middle School also had a team. But after the first year, it did not have enough signups, so ever since 2009 its athletes have played for Holmes.)
In all, Coronado's 52-man championship roster included 5 from West and 40 from Holmes, according to Kreidel.
After the program started, it wasn't long before then-Coronado coach Bruce Gross "started connecting to the middle school program," explained Bobby Lizarraga, the current Coronado coach. And he's kept it going since taking over from Gross four years ago.
The result has been players arriving at high school with a better understanding of the game. "It's made a lot of difference in prepping these kids and helping them understand what's expected at the high school level," Lizarraga said.
The cooperation is not just one way, either. The Coronado coaches work with their Holmes counterparts, and in some cases knowledgeable parents who've volunteered with the middle-school program have moved with their sons to fill similar roles at the high school.
Some Coronado coaches who've also helped out at Holmes are Gerry Strabala (son Ryan), Scott Edmunds (son Wesley), Darin Smith (sons Sam and Joah), Chris Gregory (sons Michael and Christopher), Craig Carly, Paul Sinatra and Caleb Muth.
"The support from the Coronado coaches has been phenomenal," Wilshusen commented.
An early indication that something special was happening was in 2010, when Holmes won the city football championship. "That core [Coronado juniors this year] from 2010 is still there," Kreidel said. He remembered that he and Wilshusen both had a good feeling about their chances. "They were smart and [a rarity in many schools] learned to play both sides of the ball."
At Holmes, the budding players get insights into teamwork, fundamentals and even some of Coronado's offensive and defensive schemes. The "smashmouth" running game behind all those Cougar comebacks? The players began learning that at Holmes. "The front line is where everything starts, with a real simple blocking scheme," Kreidel said. "You dominate the line and go in and gain yards."
Conditioning too. Sets of small hills lie on the undeveloped land behind Holmes. To get in shape, the middle-school coaches have the players regularly run them. A pleasant memory for Kreidel is how the boys now at Coronado willingly accepted that part of the training, and that they did it together. "You could see them going up and down them, as a team," he said.
Wilshusen also spoke to the character building that's part of the coaching effort, which emphasizes life skills, family support and "giving their best effort in everything they do. We're focused on trying to build their self esteem and confidence," he said. "And we try to get parent involvement, to get everyone realizing that it's not just the football team, it's the success of everyone involved and that winning is a byproduct of effort."
One of the parents, Rosa Medellin, has had two of her sons play for Coronado. Aaron, the younger, was the senior center on this year's team until suffering a knee injury in the first playoff game. He was one of the players originally from West Middle School who became part of Holmes' team in 2009. She praised the coaches for helping him and the parents from West feel at home. She also likes the part about requiring players to keep their grades up if they want to play. "Those are good coaches over there," she said.
In summing up the current status, Wilshusen offered an understatement similar to his guarded prediction in 2008: "We're trying to create a sense on the Westside that something special is happening here, that the players we have are going to be on JV and varsity at Coronado soon," Wilshusen said. "I'd like to think some of that is helpful."
Westside Pioneer article