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Ctrip sees strong start to 2017
Leading Chinese online travel firm Ctrip reported first quarter figures for 2017 at the end of last week, demonstrating a strong underlying business. Net revenue for the three months ending March 31 rose an incredible 46% from the year-ago quarter to RMB 6.1 billion. This is a beat against analysts' expectations of 2%. The share price dropped slightly following the news, but this is likely a reflection of its incredible rise already this year – and in any case, the decline reversed itself the following day.
Ctrip is up an incredible 38% so far in 2017
SOURCE: Yahoo Finance
One of the most important narratives about Ctrip in the first quarter is the demonstration of its successful implementation of an acquisitions strategy. The company bought competitor Skyscanner last year in order to dominate the market, and it has achieved its goal. With around 80% market share in the OTA space, Ctrip has been able to decrease its marketing spend significantly and implement new economies of scale. The result is a big win on its bottom line: +7.6% to gross margin (now at 80.5%), and a huge increase in operating margin to 15.4% of revenue from just 0.2% in the previous year.
James Liang, Ctrip's executive chairman, said: "This is the first quarter we consolidated Skyscanner results. By leveraging Skyscanner and other strategic overseas investments, we expect to further strengthen our international product offerings and improve user experiences for both Chinese and international travelers."
Meanwhile, the group's CEO, Jane Jie Sun, said: "We kicked off 2017 with great results. The group has continued to achieve healthy revenue growth and margin expansion. We have also been making great strides in penetrating into lower-tier cities and expanding into international markets, thanks to our teams' strong execution and strategic investments."
Dominion holds Ctrip in its Global Trends Luxury Fund.
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Welcome Home
new school living
> > in jp
Be part of a newly renovated historic school building in the heart of Jamaica Plain. Reclaimed wood floors, huge thermal windows, and modern finishes create unique loft apartments. Studio and one bedroom lofts are creatively laid out, allowing you to enjoy this vibrant neighborhood in a bike friendly and eco-friendly place you can call your own!
20 Sunnyside Street, Jamaica Plain, Massachusetts
617 433 8231
Off Centre Lofts • 20 Sunnyside • Jamaica Plain, MA • 617 433 8231 • firstname.lastname@example.com

subset: commoncrawl


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Protecting Memories | UMMC to Lead in $26 Million Nationwide Alzheimer's Study
Produced by Jim Albritton | The University of Mississippi Medical Center and four collaborating academic medical centers have received a $26 million grant from the National Institutes of Health to identify risk factors for Alzheimer's and related forms of cognitive decline. The multi-year study, building on clinical data collected from 16,000 patient participants over 20 years, is expected to give researchers a unique window on the early physiological changes that might eventually culminate in Alzheimer's.
The NIH grant and the creation of the MIND Center (Memory Impairment and Neurodegenerative Dementia Research) was announced at a press conference at UMMC. Supporters of the new research center combating Alzheimer's disease and dementia also announced a $9 million campaign aimed at raising private funds to support its work.


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War preparations were zealously pursued by people on both sides.
Tuesday, April 30, 1861
Two hundred ladies, with their needles and thimbles, met at the Town Hall Tuesday morning, April 30, at ten o'clock. After prayer by the Rev. Dr. Arnold, of the Baptist Church, and the singing of a hymn, the different garments, "consisting of four dozen blue-flannel shirts and four dozen pairs gray-flannel drawers," were distributed. The work progressed steadily for four or five hours, until the allotted task was completed. This work was for the State. Subsequent meetings for preparing uniforms for the Westborough company were frequently held until the 20th of June. The result was the thorough equipment of the company (the town furnishing the material, and J.A. Trowbridge, who then had a tailor's shop, attending to the cutting) with uniform, fatigue-suit, havelock, thread-bag, towels, handkerchief, soap, and comb for each soldier.
A Walk Among Storied Tombstones: The Irish of Alexandria National Cemetery - The latest instalment of the series focuses on Alexandria National Cemetery, which I visited on my recent trip to the United States. The majority of buri...
1 day ago


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The Marlipins Museum is aa beautiful 12th century building in the middle of Shoreham but it will stay open only if there are enough volunteers to cover five days a week from May to October.
The Friends of Marlipins Museum desperately needs more custodian volunteers as it has lost six wonderful people through illness and moving out of the south east.
Liza McKinney said: "If you can spare just three hours a week or a fortnight from May 1 to October 31, we would love to have you join us.
"You do not need to be a history buff – just someone who enjoys meeting people and working in a lovely place.
"It is voluntary but we are a friendly bunch and you would always work with someone who has been a custodian for a long time to support you.
"You have a chance to meet people from near and far, learn about local history and enjoy the museum events and special activities."
Telephone Liza on 01273 462233 or visit www.friendsofmarlipins.org.uk
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Over 100 Air Cadets turned out at the Aeroventure aircraft museum at Doncaster Lakeside to commemorate the 75th Anniversary of the Battle of Britain, with a parade and service.
The parade formed up for a march past outside the Doncaster Air Museum main hanger. The reviewing officer was retired Air Vice Marshal Alan Johnson, who took the salute. The march passed was accompanied by the cadet band from 148 (Barnsley) Squadron.
The Revd Neil Redeyoff led a remembrance service.


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In the spirit of Christmas and domaining I decided to write my first comic. I used to do it all the time but Mr. Patrick is kind of known for his and I didn't want to steal his thunder. Let me know if you like it. If you don't…………….Merry Christmas
Merry Christmas… and my First Comic
Dec 25 2009
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This week's coaching topic is about Belief!! We all have things we believe deeply in. I challenge you to increase your BELIEF level this week!! You need to BELIEVE!
In this video I assign a "homework" task for you…
Here's the video:
A few of my Beliefs:
~I believe… in Jesus! My Christian Testimony
~I believe… I LOVE YOU ALL!! It is fun to have such great friends like you~ and it is really fun to realize I truly LOVE YOU!!
~I believe… thistles have beautiful flowers Isn't that amazing…that a horrible icky weed like thistles can have VERY beautiful flowers?! I was running outside today around the yet to be built area of our neighborhood and the lots were full of TALL thistles…and noticed how pretty the purple flowers were on them. God probably made them that way as a reminder that even things (or people) in life that poke us, hurt us, stick us, cut us, etc…. still can produce beautiful flowers!!
~I believe… in the power of REST! In looking back at this week, I had a GREAT one. I took a couple extra days "off" of working out, but made my workout days count and It was great despite it is usually one of my roughest hormonal times (c-days: 19, 20, 21, 22) of the month!!! I am pumped about it~ I followed my own advice and RESTED more than I usually let myself REST and it keep myself HAPPY, unstressed, productive, loving, patient and healthy! In addition to the rest I was a good girl about taking my "boosting" supplements and they always help with keeping my hormones balanced. Soooo, I feel great! and ready to hit my LEG workout today HARD and have another super week of Boosting!!
~I believe… in Adrenalin~ I love thrills and wild rides- watching wild fight, wild sports etc…I am an adrenalin junkie and I'm excited for the adrenalin to come this week!
~I believe… in PURPOSE. WE ALL have a purpose for our lives…do you have a vision of what your's is? I know mine…it is to HELP WOMEN- as simple as that! I'd like to help every woman in the world have HOPE- I want to share the message that YOU have the power to change YOUR body, life and legacy.Does that sound do-able? LOL! I BELIEVE it is!!Now, I have not always had this VISION for my PURPOSE…it has taken time, effort and GOD's timing to reveal it in my life. I've only had a CLEAR VISION for my purpose for the past 2-3 years. Until then I was searching and honestly more than a little frustrated…I had an uneasy feeling, I knew I was supposed to do something, but WHAT??I really believe that God put me through every part of my life for a reason…even the bad parts. I now see how things that seemed bad at the moment, have turned to work for my favor NOW. I've also gained a ton of WISDOM through my struggles and my triumphs. Without the past 32 years of my life I wouldn't be me and I wouldn't be ready to attack my PURPOSE.A couple books that helped me in finding my purpose are: the BIBLE, "Reduce me to LOVE" by Joyce Meyer and "The Prayer of Jabez" by Bruce Wilkinson Keep on Believing and keep striving towards your PURPOSE…YOU HAVE ONE!!
~I believe…in PAIN without it we don't know the joy of being pain free, lol!
NO PAIN, NO GAIN is also true~ if you want results you have to push into some pain…lactic acid pain, the pain of sacrifice, the pain of having to take ANOTHER shower! ON AND ON…. PAIN is an important part of life!I
~I believe… To WIN no one needs to LOSE~I read that statement somewhere last week…and it STRUCK me! I am very competitive, and LOVE to WIN…AND I also LOVE seeing others win. HOWEVER, there are times when I catch myself in a contest with someone wishing that they would LOSE~so I can WIN. I DON'T want to EVER think that way.
That's why I LOVE that no one has to lose in order for ME to win!! We can all win~ woohoo!
~I believe… in leading by my actions…case in point my workout today. I don't ask my clients to do anything I am unwilling to do myself. SOOOO…Since, I am on the same workout schedule as one of my clients LISA of NE, I decided to do the same workout as her today. The friendly "competition" really helped push me to excel and be relentless! Thanks LISA!
~I believe… my day was a good one! I am rather sore…I guess that's what happens when you don't workout for a week or so, lol!
I believe in relationships…we are made for this purpose. The reason God created man was so he could have "relationship"…that is AMAZING! And makes me realize that the HAPPIEST times of my life have been when I am actively seek out relationships with other people. I am a very independent person and have at times a tendency to isolate myself from interacting with others. It is my natural "I can do it better by myself" attitude. However, it is not very fun nor is it very rewarding when others are not involved in the process or the reward. That's why I love the Rally Room! It keeps me in relationship with others and gives me a place to easily give my energy away through encouraging others!! I love the RELATIONSHIPS I have been blessed with in TEAM BUFFMOTHER!!
Some GREAT Belief Quotes:
Mark 11:23,24 Jesus said " I tell you the truth, if anyone says to this Mountain, 'Go throw yourself into the sea' and does not doubt in his heart but believes that what he says will happen, it will be done for him. Therefore, I tell you, whatever you ask for in prayer, believe that you have received it and it will be yours."
"You've got to believe you've got it, before you get it"- Joyce Meyer
"As long as people believe in absurdities, they will continue to commit atrocities." -Voltaire
"When someone shows you who they are, believe them the first time."-Oprah
"God didn't have time to make a nobody, only a somebody.I believe that each of us has God-given talents within us waiting to be brought to fruition."~Mary Kay Ash
"Four things for success: work and pray, think and believe."
-Norman Vincent Peale
"You can do it if you believe you can!"-Napoleon Hill
Keep on Believing Ladies~


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The Institute of Jamaica (IOJ) invites you to its annual Research Symposium 2012, the symposium will be held on Wednesday November 28 at the IOJ Lecture Hall, 10-16 East Street. The Symposium will be held under the theme, "Embracing our History, Culture and Heritage".
Registration is at 9 a.m. Presentations 9:30 a.m. to 3:00 p.m.
Oral Presentations will include:
- Tracian Meikle: "Playing the 'Race Card': Pre-Independence Black Nationalism in Jamaica" (The African Caribbean Institute of Jamaica/Jamaica Memory Bank).
- Donna McFarlane: "From British to Folk: Recalibrating Identity through the Folk Museum" (Liberty Hall: The Legacy of Marcus Garvey)
- Sasha-Kay Osbourne-Weir: "Is Revivalism the New Pentecostalism?"(Museums of History and Ethnography)
- Veerle Poupeye, PhD: "Objects of Power: Some Preliminary Notes on Late 19th Century Obeah Figural Carvings from Jamaica." (National Gallery of Jamaica)
- Kerri-Ann Palmer: "TEACH THEM, REACH THEM…The Impact of the Parenting Workshops held at the Greater Portmore Junior Centre between 2009 and 2011 on the Parent-Child Relationship" (The Coordination Division/The IOJ Junior Centre)
- Jason Ramsay: "Transforming Historical Buildings into Museums"(Museums of History and Ethnography)
- Tracy Commock: "Picking Flowers: Reflections on the Selection of Lignum Vitae as the National Flower" (Natural History Museum of Jamaica)
The following posters will be displayed:
- Kenisha Rowe: "Proud Defiance: Black Working-Class Women in Jamaica During the Victorian Era" (Museums of History and Ethnography)
- Judeen Meikle: "Georeferencing of descriptive locality data on herbarium specimens" (Natural History Museum of Jamaica)
- Dorsia Brooks: "St. Catherine's Wild Cats; A Study on the Occurrence and Perceptions of Feral Cats in the Parish of St. Catherine". (Natural History Museum of Jamaica)
- Suzanne Davis, Ph.D: "Impact of an Invasive Fern on Bird Diversity in a Jamaican Ramsar Site" (Natural History Museum of Jamaica)
- Shani Roper: "Pharmaceutical Bottles in the Port Royal Collection of the Institute of Jamaica" (Museums of History and Ethnography)
- Patrice Russell: "An Impact Assessment of the Biodiversity Awareness Programme on the Knowledge and Awareness of the Student Members of the Chandler's Pen Primary & Junior High School's Environmental Club." (Natural History Museum of Jamaica)
- Leleka Johnson: "The Anthony Robinson Manuscript – A descriptive and enlighten manuscript on Jamaica's Natural History" (Natural History Museum of Jamaica)
Secure parking will be available at 24 Hanover Street.
If you have any questions, queries or concerns please contact Mrs. Tracy Commock, Chair of the IOJ Research and Curators Committee and Director of the Natural History Museum of Jamaica, at 922-0620, extension 308 or email her at firstname.lastname@example.com


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We know how important having the right mindset is to ensuring that every student learns the right way, so we create calm environments for our students, allowing them to develop in the way they're most comfortable with and feel confident behind the wheel. Make the right choice for your driving career and choose to learn with the team at Metro Driving School.
We know how difficult it can be to fit in a driving education around work, school, social commitments and more, so we make booking lessons easy. Just jump on to our online booking portal, pick your preferred length of lesson, select your date and time and lock it in. With our system, you can book a huge number of lessons well in advance, ensuring that you're getting the consistent, high-quality tutelage you need to be a safer driver.


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Apparently not content with medicating more than one out of every five Americans with mind-altering and potentially dangerous psychiatric drugs, the Big Psychiatry and Big Pharmaceutical industries are working to promote their latest invented "mental disorder" supposedly requiring their benevolent and costly assistance: Being too concerned about eating healthy. Calling the proposed new "disorder" orthorexia nervosa, the increasingly discredited establishment press has so far been more than happy to unquestioningly parrot the notion that people deeply concerned with eating healthy and nutritious food are somehow "ill" and in need of expensive "treatment." As public knowledge of toxins in processed food and genetic engineering spread, the "disorder" is apparently surging in tandem.
The dubious diagnosis of so-called "orthorexia," which translates roughly into righteous or correct eating, was first proposed by Dr. Steven Bratman in 1997. He originally defined it as "an unhealthy obsession with eating healthy food." Outside of psychiatry, it was largely ignored or ridiculed. Even many psychiatrists balked as the whole industry faced increasing scrutiny over its accelerating efforts to expand the list "mental disorders" by just making more up — along with expanding the potential pool of "patients" in need of supposed "treatment." A handful of articles discussed it over the years, including a 2005 piece in the state-funded BBC and a 2011 article in the Huffington Post.
Starting late last year, though, almost certainly with an expensive public-relations propaganda campaign operating behind the scenes, Bratman's alleged "disorder" gained a great deal of traction in the establishment press. Indeed, inside a period of just a few months, the Wall Street Journal, CNN, ABC News, and other media outlets all began hyping the supposed "disorder" as if it were a totally legitimate disease that had just been discovered and was fast becoming another scourge on mankind. All of the articles indicated that the alleged condition was on the rise, failing to mention growing awareness about widely distrusted genetically modified organisms (GMOs) and various toxins often found in processed foods. Just 37 percent of Americans think genetically engineered food is generally safe to eat, according to a recent survey.
In the media, though, "orthorexia" was treated as deadly serious. The Journal, for example, called it "a little-researched disorder," and claimed that researchers were coming up with "criteria" for clinicians to "diagnose orthorexia." ABC News even found an eccentric 23-year-old woman whose "perfectionism" surrounding food had supposedly "morphed into a full-blown eating disorder called 'orthorexia nervosa.'" Not to be outdone, CNN claimed: "There's now a name for people dangerously addicted to all things healthy — a sufferer of orthorexia nervosa." Popular Science, Fast Company, and other media outlets also began hyping the supposed disorder. Despite all of the hysteria, however, there seems to be little agreement on what precise combination of seemingly arbitrary "symptoms" must be exhibited to qualify.
In traditional medicine, objective biological diagnoses can be made because there are real medical problems being dealt with — a broken bone on an x-ray, a bacterial infection, and so on. With "orthorexia," though, like virtually all of modern psychiatry, there are no objective criteria or biological tests. Indeed, psychiatrists actually vote regularly to literally invent or redefine supposed diseases, "symptoms" that go with their newly created "disorders," and what drugs ought to be used to treat them. While what critics call the latest "quackery" has not yet been formally added to the ballooning "bible" of psychiatry known as the Diagnostic and Statistical Manual of Mental Disorders (DSM), the recent PR campaign appears to be setting the stage for its eventual inclusion.
Even the DSM, though, is coming under increasing fire. Duke University psychiatry professor Allen Frances, who served as the lead editor of the fourth edition of the American Psychiatric Association's DSM, explained that "there is no definition of a mental disorder." In fact, "it's bull****," he said as he attacked the very foundations of psychiatry's "diagnostic" tool. "I mean, you just can't define it." "The DSM is distinct from all other diagnostic manuals because it has an enormous, perhaps too large, impact on society and millions of people's lives," explained Dr. Frances, who also worked on previous editions of the manual. "Unlike many other fields, psychiatric illnesses have no clear biological gold standard for diagnosing them."
In 2012, as the DSM was being updated and packed with new and improved labels, the problems only grew. In an unprecedented rebellion, 13,000 mental health professional from around the world were so outraged at what they saw that they attacked it publicly in an open letter calling for the manual to be put on hold and reconsidered. "[The DSM] is wrong in principle, based as it is on redefining a whole range of understandable reactions to life circumstances as 'illnesses,' which then become a target for toxic medications heavily promoted by the pharmaceutical industry," clinical psychologist Lucy Johnstone with a Health Board in Wales told Reuters at the time. "The DSM project cannot be justified, in principle or in practice. It must be abandoned so that we can find more humane and effective ways of responding to mental distress."
For the psychiatric and pharmaceutical industries, however, the DSM and its perpetually mushrooming list of invented "disorders" means big money. In a widely reprinted report first published by the Natural Society, journalist and researcher Jefferey Jaxen lambasted the drive to label those concerned about healthy eating as mentally disordered. Suggesting it was an establishment attempt to curb growing consumer demand for healthy and nutritious food, Jaxen also attacked the psychiatric industry and its close relationship with the pharmaceutical industry as an unholy alliance aimed at fleecing consumers by inventing more "disorders" to be treated with their "toxic products" as the supposed answer.
"The cherry on top is that if you have the pseudo-science labeled disorder of orthorexia nervosa, you will be prescribed known toxic, pharmaceutical drugs from some of the same conglomerate corporations that you are trying to avoid by eating healthy in the first place," he wrote, pointing out that efforts are underway to label even creativity as a mental disorder. "As the people continue to walk away from the broken medical and agricultural/food systems like any abusive relationship, the food makers are willing to do anything to maintain their waning control…. Perhaps some people to take it too far to the point of self-harm, but the problem we face with a toxic food system is a much larger threat."
Indeed, beyond what critics say is wild overmedication and over-diagnosing of "mental disorders," some experts have raised an even more troubling specter. As The New American reported in 2012, former U.S. Marine Brandon Raub was detained in a psychiatric ward by law enforcement over anti-government Facebook posts. "The police state is here," explained John Whitehead, president of the Rutherford Institute, about Raub's case. "For government officials to not only arrest Brandon Raub for doing nothing more than exercising his First Amendment rights but to actually force him to undergo psychological evaluations and detain him against his will goes against every constitutional principle this country was founded upon. This should be a wake-up call to Americans." Of course, the mass-murdering regime ruling the Soviet Union became infamous for its use of "psychiatry" and quack diagnoses to disappear and discredit political opponents.
While there may indeed be a tiny handful of people who are what most would consider "too" concerned about healthy eating, critics of the effort to make "orthorexia" into a "mental disorder" said the issue highlights a growing and troubling trend. DSM-IV lead editor Dr. Frances, for example, warned years ago that the overly broad and vague definitions of "disorders" would create more "false epidemics" and increase the "medicalization of everyday behavior." His motivation for speaking out, he wrote in Psychology Today, was to prevent "diagnostic inflation" that would result in the "mislabeling of millions of people as mentally disordered."
As psychiatry increasingly seeks to label any and all emotions, beliefs, and actions as "disorders," healthy eaters and the general public ought to be paying attention. If the industry and its Big Government allies are left unchecked, Americans may wake up one day to find that they, too, have some newly invented "mental disorder."
Alex Newman is a correspondent for The New American, covering economics, education, politics, and more. Follow him on Twitter @ALEXNEWMAN_JOU. He can be reached at:
Related articles:
Critics Blast Big Psychiatry for Invented and Redefined Mental Illnesses
Research: Antipsychotic Meds Cause Hopelessness, Zombie-Like State
Former Marine Held in Psychiatric Hospital Over Facebook Posts Questioning Govt.
GMO Giant Monsanto Joins Big Business Coalition for UN Agenda 21
Psychiatric Meds: Prescription for Murder?
Using "Mental Health" to Take Away Guns
UN Seeking Global "Mental Health" Plan
Are Mental Health Professionals Working to Normalize Pedophilia?
Could California Parents Lose Rights to Help Homosexual Children?
Is the APA Playing Politics With Sexual Disorder Definition?
Russia Bans GMO Corn Over Cancer Fears as Pressure Builds on Monsanto
France Responds to Study of GMOs That Shows Links to Tumors and Organ Damage
Psychiatric Group Backtracks on Pedophilia Classification


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At the Cottage Door
Her Dower, study of A Girl Arranging Linen
Lady of the House,
Harbingers of Spring, 1911
Daffodils, detail
Title unknown
The Laundry Maid, 1920
The Sea Haths Its Pearls, 1897
che qualcuno venga a te e vada via
senza essere migliore e più contento.
Sii l'espressione della bontà di Dio.
Bontà sul tuo volto
e nei tuoi occhi,
bontà nel tuo sorriso
e nel tuo saluto.
Ai bambini, ai poveri
e a tutti coloro che soffrono
nella carne e nello spirito
offri sempre un sorriso gioioso.
Dà loro non solo le tue cure
ma anche il tuo cuore.
Madre Teresa di Calcutta, da "La Gioia di amare"
- picture 1 - Fresh Lavender, 1909
William Henry Margetson (1860-1940) was an English painter active during the late Victorian era and the Edwardian one known for its full-length portraits of pretty girls, always smiling, with a clean, simple, seren and cheerful face, only protagonists of his canvas with their humility
- picture 2 - At the Cottage Door
- picture 3 - Her Dower, study of A Girl Arranging Linen
- picture 4 - The Morning Walk
that shines through their eyes, bright with the joy that only modesty allows to reach and makes it possible to give it.
When his subjects don't watch the painter they seem to be caught in the serene moments of their daily activities, and communicate to the viewer, anyway, joy and peace of mind ...
- picture 5 - Barbara Allen
- picture 6 - Lady of the House
- picture 7 - Harbingers of Spring, 1911
- picture 8 - Daffodils, detail
- picture 9 - Title unknown
- picture 10 - The Laundry Maid, 1920
- picture 11 - A Moment's Reflection
He lived in Wallingford on Thames and led studies of art at the South Kensington Schools, and perfected them at the Royal Academy where he began to exhibit in 1885.
Alongside portraits of contemporary young girls, Margetson also started to give life to images of religious scenes
- picture 12 - St. Mary at the Loom
- picture 11 - Ecce Homo
of allegorical nature
- picture 13 - The Sea Haths Its Pearls, 1897
- picture 14 - The Stranger, 1902
and classic / ancient ones.
- picture 15 - Cleopatra
With the beginning of the century, he devoted himself, with some success, to the creation of watercolor illustrations regaining the radiance on the faces he first portrayed, which probably gave him success.
- picture 16 -
Hope it may reach you, deeply joyous, my most affectionate greeting, full of gratitude and sincere devotion,
see you soon ♥


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A wealthy Burmese businessmen, Htay Myint, is establishing a massive mono-crop plantation in the world's largest tiger reserve in the Hugawng Valley in Kachin State in northern Burma, according to Kachin environmentalists.
Htay Myint, the owner of Yuzana Company, is on the US and EU's targeted sanctions list because of his ties with the Burmese military regime.
The Yuzana Company was granted 200,000 acres in the Hugawng Valley Tiger Reserve in 2006 to establish sugar cane and tapioca plantations, according to a report titled "Tyrants, Tycoons and Tigers" released on Wednesday by the Kachin Development Networking Group (KDNG), an Kachin environmental group.
The report documents how fleets of bulldozers and backhoes have razed forests and destroyed animal corridors, while leaving the conservation group's signboards standing.
"The destruction in Hugawng makes a mockery of the tiger reserve," said Ah Nan, a spokesperson of the KDNG.
The report also highlights the struggle of indigenous farmers who are being forcibly relocated to make way for the plantation. If they complain, farmers have received threats from employes of the Yuzana Company, according to the report.
The reserve was established in 2001 with the support of the US-based Wildlife Conservation Society (WCS). WCS has remained silent on the encroachment into the reserve, according to the KDNG report.
Htay Myint said, in a meeting attended by Burmese officials, ministers and businessmen in mid-August, that he will run as a candidate for a constituency in Tenasserim Division, and that he plans to spend more than 100 million kyat (US $101,500) on his campaign, according to sources close to military officials.
Ah Nan said, "These tycoons are a new face of tyranny in Burma. They're set to enjoy even greater power after the elections."
Burma's military regime recently outlined a National Tiger Plan, in which it said it will double the country's tiger population by 2022. The plan will be submitted at the Global Tiger Summit in later this year.


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W3C | TAG | Previous: 22 Mar teleconference | Next: 29 Mar
Nearby: Teleconference details · issues list (handling new issues)· www-tag archive
See also open actions by owner and open issues.
See email from Danny Weitzner and email about timing expectations.
Actions 2004/03/15 (due 25 March?) to review sections:
The TAG did not discuss issues below this line.
The TAG expects to review the list of open actions by owner and to close any that are obvious to close. TAG participants are encouraged to review this list before the meeting, as well as other action items listed in this agenda.
See also TAG findings


text:
Colours Choose a colour below
Colour variations may differ due to the type of
leather, different dyes used on the leather and oiling. *
This product is made with soft leather which comes in different grains. The bag is unlined to allow for the genuine feel of the leather and to encourage a rugged feel.
Hand cut, sewn and coloured
Colour varies depending on leather type and grain
Customisable to suit your specific needs
Length: 34cm
Width: 10cm
Height: 23.5cm


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Still haven't signed up for The Husband Project Online Bible Study with Proverbs 31 Ministries?
Too tired? Tired of working on your marriage and not seeing a difference?
You are not alone…… but before giving up on the idea of joining us on The Husband Project, listen to my conversation with Cheri Gregory. We cover everything from the Chewbacca Mom video to real objections Cheri had about joining Online Bible Study. You'll laugh, you'll nod your head, and you'll leave with at least a little bit of hope. I promise.
Mentioned in the podcast:
The Highly Sensitive Person book
Sensitive: the Untold Story documentary
"HSP—Who, Me?!?" free downloadable assessment
"You're NOT Too Sensitive: the Strength of a Tender Heart" 10-Day Email series for HSPs
Cheri's Facebook page for HSP wives doing The Husband Project via Proverbs 31 OBS
Join us for the next Online Bible Study: The Husband Project by Kathi Lipp
What if the key to a better marriage starts with you?
With The Husband Project you'll be equipped to:
- Prevent complacency in your marriage by learning practical ways to do something intentional, every day, for your husband.
- Overcome the feeling of "not being enough" and pursue every option to make your marriage what God intended it to be.
- Discover the unique plan God has for your marriage and your role as a wife with weekly projects.


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Plot Summary:""
When will people learn that they can't sneak a crud film past the noses of seasoned horror fans by giving it a new title and cover art?
The abysmally titled 'Halloween Camp 2: Scream if you wanna die faster', is a boring tale of some graduating teens who head off to camp and encounter a masked slasher whose weapon of choice just happens to be a crossbow.
Whilst the film was occasionally easy on the eye, it was simply boring with the first one of the teens dying at around 40 minutes in!!
The cast are all relative newcomers and their performances were all hit and miss but the plot was terrible.
I knew in the opening sequence who the killer would be and I was right!! This one uses every tired cliche in the book and doesn't put any originality into it either.
It's pretty slick looking and has a decent score/soundtrack but for all it's gloss it is neither scary nor entertaining. Why spend all that money on a below par story when plenty other low budget films could have been improved massively with the budget from this?
Adam & Evil truly is a rotten apple, but gets merit for its score and soundtrack.


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BRENDAN RODGERS has praised Liverpool fans for their "incredible" support during a tough start to the season.
The Reds have won only two of their opening 10 Premier League games ahead of tomorrow's trip to Chelsea.
"I have got so much respect for the supporters because it must be frustrating for them considering what they have had at the past at this club and where we are currently at," said Rodgers.
"But I also believe we can't keep looking in our rear view mirror. If we keep looking back we will never go forward. We are in the situation we're in, where we have a thin squad. I now have to try and grow that.
"Hand on heart, the support we've had has been great. The club hasn't won many games at Anfield over a period of time, but it's certainly nothing to do with the supporters.
"The support is incredible and against Newcastle last weekend they really picked us up and lifted us. They got us that point. We should have gone on to win that game and that came from our support, it was absolutely phenomenal and I don't think that will change.
"This is their football club and we have to try and give them a team they can be proud of. What we're showing at the minute is a lot of character and that bodes well going forward."


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Eastern Wake: Community
Notables, March 3
Elon honors
Elon University has released its list of students who made the President's List and Dean's List for the fall semester of 2013.
Ruby Marie Gibbs, of Knightdale, made the President's List. She is the daughter of Barbara Gibbs.
Jane Marie Seidel, of Knightdale, made the Dean's List. Jane is the daughter of David and Suzanne Seidel.
Kali O'Ryan Snuggs, of Wendell, made the Dean's List. Kali is the daughter of Erin and Kristi Snuggs.
Students recognized
Three eastern Wake County students were recognized as DAR Good Citizens by the General James Moore Chapter of Daughters of the American Revolution at their monthly meeting in Wake Forest: Rachel Kate Cockrell, daughter of Bobbie and Jean Cockrell, from East Wake School of Health Sciences; Nicholas Xavier Sanders, son of Julio and Felicia Sanders, from East Wake School of Engineering Systems; Orvellin Villarreal, Jr., son of Orvellin and Irma Ocampo Villareal, from East Wake School of Integrated Technology; and Anna Kate Whitfield, daughter of John and Rebecca Whitfield, from East Wake School of Arts, Education and Global Studles.
The DAR Good Citizens award and scholarship contest rewards high school seniors who possess qualities of dependability, service, leadership and patriotism in their communities. Selected by faculty, students are then invited to participate in the scholarship portion of the program.
Mills receives martial arts scholarship
Local Knightdale High School senior Joshua Mills has received the Nathaniel and Beula Ray Bu Bun Ryo Do scholarship from Supreme Martial Arts & Fitness in Knightdale. The scholarship is given to students who participate in the martial arts and exemplify the drive to discipline both mind and body.
Merit Scholarship finalist
Grant Masini, a senior at Corinth Holders High, has been named a finalist in the 59th annual National Merit Scholarship program. Merit Scholar Finalists are selected on the basis of their skills, accomplishments, and potential for success in rigorous college studies and compete for approximately 8,000 National Merit Scholarships with a combined worth of about $35 million.
Masini was entered into the 2014 National Merit Scholarship Program by taking the Preliminary SAT/National Merit Scholarship Qualifying Test and receiving one of the highest scores in the state.
CFSP re-certification
Cary B. Cannady, CFSP, a funeral director with Montlawn Funeral Home, has recently qualified for re-certification of the designation of Certified Funeral Service Practitioner by the Academy of Professional Funeral Service Practice. To initially receive this award, the practitioner must complete a 180 hour program of continuing education activities and events. The practitioner is required to accumulate 20 hours per year to re-certify.
Hatcher at Sigma Tau Delta
Wendell native Rebecca Hatcher was one of four undergraduate students at Campbell University to present her research at the Sigma Tau Delta International English Honor Society's annual conference in Savanna, Ga. Hatcher, a member of Sigma Tau Delta, studied Samuel Taylor Coleridge's "Christable," which explores the corruptibility of women and the nature of temptation to evil.
Silver award
Camille and Hanna Olson of Wendell have been awarded the Girl Scout Silver Award by Girl Scouts – North Carolina Coastal Pines. The Silver Award is the second highest achievement in Girl Scouting. The award symbolizes Girl Scout Cadettes' accomplishments in Girl Scouting and their community as they discover their strengths and take action to make the world a better place.
For their Girl Scout Silver Award project, the girls constructed two benches for a Wendell community park. After gaining approval from the Parks and Recreation Department, the girls installed the benches along walking trails in a newly expanded area of the park. The girls hope that the benches will help attract more people to come out to the park and use the new and existing trails.
The Olson girls have been Girl Scouts since 2005, and are members of Girl Scout Troop #1434 led by Stephanie Hawke. They are the daughters of Jon and Kim Olson and are in the 9th grade.
WCU graduates
Three area students graduated from Western Carolina University during the Fall 2013 semester. Gabrielle L. Ellis, of Knightdale, graduated with a Bachelor of Science in sociology; Elizabeth Ann trace, of Knightdale, graduated with a Master of Health Sciences; and Edward Jason Dennis, of Wendell, graduated with a Masters in Project Management.
WCU Dean's List
Western Carolina University has released its list of students who made the Dean's List. From Knightdale, Devin Gabrielle Devore, Candace D. Thompson, and Kimberly Rebecca Ward were named to the Dean's List. From Wendell, Veronica Nicole Browning and Lauren Olive; and from Zebulon, Michelle Jacqueline McDuffie.


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1949 logo t-shirt
Estimated delivery: 1 - 2 working days. More info
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Stay classy in the 1949 Logo adidas t-shirt for women that features a high quality, stylish flat ink graphic print design. Created to keep you dry during those high intesnsity training sessions thanks to the climalite® technology based fabric.
- Separate drawstring bag for a better gear arrangement
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- Material Composition: 100% Polyester


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Article Summary:
Original Article Text From El Economista via Google Translate :
Minimum wage will rise to 18% in Panama
The Panamanian government approved raising the minimum wage in the private sector from 15% to 18% from January 2012, the new rates were set according to economic activity, occupation and firm size.
The Minister of Labour, Alma Cortés said the wage increase decreed by the Executive, having failed negotiations for several months held employers and employees to establish a new minimum wage earn about 250 thousand employees. "We are aware that we will not look good either with employers because they will see very high, and with the workers, because they will not meet your expectations, but I am confident that is the best decision you have taken for the country, "Cortes said in a press conference.
The minimum wage in effect until December averages $ 416 dollars. The new rate will be applied based on two industrial regions, number one, which includes Panama City, Colon and San Miguelito, recorded the highest salaries.
Cortes noted that for both areas increases the range varies by activity and type of occupation with special treatment for small businesses and the agricultural sector.
With the new reclassification wages are unified in areas such as mining, financial services and insurance, professional, scientific and technical, telecommunications, security agencies, and shopping malls (with more than 50 local).
The executive order also unifies wages for port workers of companies with more than 50 employees, attorneys, health technicians and journalists who have increased the minimum wage, from $ 376 to $ 490.68, an increase of 18%, said Cortes .
In the case of l domestic service, was set at $ 200 for region 1, and $ 175 for the challenge facing the country.
This is the second minimum wage set by the present Government to the private sector, the first time was in December 2009.
The president of the Chamber of Commerce, Industries and Agriculture of Panama Federico Humbert was concerned about the range of increases, which explained the proposal beyond the business sector by 7% based on technical and economic studies to prevent a cyclical effect inflationary.
He said the wage increase of 15% will cause an increase of $ 300 million in private-sector payroll , that regardless of subsequent increases in the rest of the organization of societies.
"Undoubtedly, this increase will finance a blow to private enterprise, especially given a thrust to micro and small enterprises, an important part of our economic engine," said Humbert. In contrast, workers unions considered that "the increases are insufficient" to address the decline in the value of the dollar, the high cost of living in the country and the strong economic growth would close 2011 at 10.5%, according to estimates government.
The workers had suggested a minimum wage increase between $ 540 and $ 550 per month to meet rising prices especially of basic food basket. In November, the Consumer Price Index (CPI) rose 6.8% compared with the same month last year, while in the 11 months, cumulative inflation was 6.1%, according to the Comptroller General of the Republic.
The wage increase did not include public employees, who in 2010 received a raise of $ 50. The Minister of Economy and Finance, Frank De Lima said the General Budget of the Nation approved for 2012, does not include a minimum wage increase for the public sector, but said the issue will be discussed in the coming months.
"… It is not fair that an increase in private sector minimum wage and not the officials who work in the public sector … we have to see where we make the transfer of items to make the rise," he said De Lima.


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Much like the classic Wavefarer shorts, these are designed with a slimmer profile, a more streamlined fit and slimmer through the thigh. Super comfortable with 2-way mechanical stretch and inseam free for zero chafing makes riding the waves all day in these a dream come true. Featuring UPF 50+ sun protection and a DWR (durable water repellent) finish, flat-lying closure with rubber button and ladderlock drawstring for durability. There's also a self-draining zippered pocket for valuables with an internal key loop and they come in an 18in length which makes them perfect for watersports and days on the beach.
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Robin Crowley
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314 W. Main St.
Gun Barrel City , TX 75156
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Robin Crowley
Associate, Ebby Halliday Realtors
- Direct (214)929-4520
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- 314 W. Main St.
- Gun Barrel City, TX 75156
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About Me
Born and raised in Dallas, Texas, I started my career in the hotel business and have over 20 years of experience as an administrative assistant. My husband and I moved our family to Panama City Beach, Florida in 2013 and successfully managed our vacation condominiums. Cedar Creek Lake has been our family vacation spot since 1994 and we permanently moved here in 2016. I am knowledgeable of the area, extremely organized and committed to helping you with your real estate needs. Call me today. I look forward to working with you!
- Full-Time Real Estate Professional
- Member of National Association of REALTORS®
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209 Tangle Drive Tool, TX 75143
2 Beds 2 Baths 1,180 Sq Ft
Whispering Trail Gun Barrel City, TX 75156
Northwood Place Enchanted Oaks, TX 75156
Point La Vista Malakoff, TX 75148
Colonial Drive Mabank, TX 75156
Point La Vista Drive Malakoff, TX 75148
Point La Vista Drive Malakoff, TX 75148


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CHOOSE YOUR ACCESSORY/Bike Protection/Crashbars
SW-MOTECH Crash bars BMW F650/Dakar
Body and other vital components such as your radiator are protected with a well engineered set of crash bars.
In stock
The Crash bars for the BMW F650/Dakar by SW-MOTECH has been individually crafted ensuring a perfect fit, optical integration and maximum protection.
High-strength frame mounting points are designed to provide maximum protection to both the engine and body work.
All components are protected against corrosion by sandblasting and powder coating. High-strength frame mounting points.
Special Note for Dakar Owners: You will have to remove the stock engine guard to use this crash guard.
Does not fit the 2011 and newer G650GS.
Constructed of 21.3mm outer-diameter mild steel tubing.
Features include:
- Reliable protection of important motorcycle parts
- Strong frame connection
- Black powder-coated
- Suits the appearance of the motorcycle
- pipe diameter 22 mm
- 2 crash bars
- Mounting material
- Mounting instructions
Visit our Crashbar Page for more in-depth knowledge base of all SW-MOTECH Crash Bars
|5 kg


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It appears that 2006 is going to crawl in fairly quietly for me this year as new years plans came to rather little. Way back in September I had intended to be in Edinburgh for new year, but within a few weeks of moving up plans had to be made, stress levels were faily high and at that stage I had only just met everyone. Plus the increased travel costs and rapid turn arround required meant that it threw that extra spanner in an already entangled works. So instead I resolved to spend two weeks at home, give me a chance to kick back, relax, catch up with people and spend new year among familiar faces.
Unfortunately it hasn't quite worked this way. Many of my friends are off, either with family or back in there respective homes at university or elsewhere. The few that are around are either opting for quite nights in or else are out in Malmesbury with no formal plans. Unfortunately, with my inability to drive and parents who are out I shan't be able to make this.
Thus I'm spending new years at home. I'm not the only one, it seems a common affliction for a number of people I know. My brothers have some friends arround so I needn't spend the actual transition in silence (or cheering by myself) but it does seem that things will b a little slow and the whole anti-climax that is so often new-year will be even more apparent than usual.
Tags: 2006, anti-climax, new year


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If you follow me on twitter you would know that I have been talking about making Christmas cards. I always try to make my own cards no matter what the occasion; I am not just trying to save money, trust me it would be easier and less time consuming to just buy them. I like the creativity and thought that goes behind creating a unique card for someone.
This "Mini Card Collection" was inspired by the Bauhaus Art movement. This art is not for everyone, some say it is too simplistic but I find a lot of inspiration in it. If I made these using Photoshop and Adobe Illustrator it would have been 100 times easier and faster, but call me old school. I just love the pleasure of sitting down, with paper, ruler, pencil and going for it. I want to continue to use this blog as a creative outlet and to share ideas, not just Fashion.


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Have you ever wondered what Seneca Park Zoo is like at night? Join us for one of our family sleepovers at the Zoo to find out! Through a guided tour, families will explore the Zoo at night, learning about everything the animals in our care need to survive and looking for them in their habitats. Families will also get to meet some education animals up close and make a shelter-related craft.
And don't forget to pack a sleeping bag! You'll be sleeping inside Rocky Coasts Gallery near the polar bear and sea lions.
A pizza dinner, snack, and continental breakfast will be provided.For children ages 5-10 and their adult.
Members: $60 per adult & child pair, $30 per additional person
Non-members: $70 per adult & child pair, $35 per additional person
Seneca Park Zoo, Rochester


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Backhill is a new project from Finnish multi-instrumentalist Kimmo Perämäki, who handles the guitars, bass, keyboards, and vocals on "Shadow Man". Though his musical history lies in power metal (he is a former member of Celesty), "Shadow Man" leans in a bit of a different direction. The best description of this release would be melodic metal. It's definitely a bit of a vague term in general, but it perfectly describes this album. The songs are built around great melodies, both vocal and guitar, and it sort of sounds like "easy-listening" metal. In fact, the only song on this entire album that displays any aggression is the short tune "She Said" (which is one of the stronger tracks). Aside from that, the rest of the album is more straightforward, and very easy to get into. At times, the band builds a bit of a creepy atmosphere, such as on the title track, but overall, this album is just about having fun.
Two very apt comparisons to Backhill would be the bands Altaria and Fullforce. Both are more focused on writing really great songs rather than sticking within the confines of power metal. As a result, the music ends up being a bit lighter, and perhaps alienates those who need some double bass, but the music ultimately proves very rewarding. Backhill takes a similar approach on "Shadow Man". As the album goes on, it actually strays further from metal and more into rock territory. One exception is the closing ballad "Little Lighthouse", which is neither rock nor metal. Despite being the softest song on the album, it is actually one of the best. It is a duet featuring some female vocals, and a really catchy chorus. The song actually sounds like it was written for Michael Kiske; or at least, both singers offer a similar delivery that is very effective (it's just easy to imagine how incredible Kiske would sound on this track). Another great tune is the instrumental "Jaako and the Beanstalk", which displays both Perämäki's shredding abilities and his ability to write incredibly captivating guitar lines.
Despite my praise above, I find the album to be lacking just a little. As mentioned earlier, I'm ok with it not being too heavy, but unfortunately it doesn't feel like the songs always make up for the lack of speed and intensity. When they do, this album is incredibly enjoyable, but at other times, you kind of just want Perämäki to let loose and unleash a power metal assault. At the very least, this album displays a lot of potential. There's nothing that's outright bad, but perhaps a better balance between the band's softer approach and some more rocking tunes could make the band's future records stronger. Nevertheless, this is highly recommended for fans of the aforementioned Altaria and Fullforce, as you can never have too much of that style of music!
Be sure to check out and like Backhill on Facebook!
"Shadow Man"
"She Said"
"Jaako and the Beanstalk"
"Little Lighthouse"
Final Rating
3.75/5 or 75%.
Written by Scott


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Microalgae at the heart of our expertise
Invisible to the naked eye, microalgae populate the oceans and produce 80% of our oxygen. At the origin of all living organisms, they are astonishingly similar to the skin and contain a wealth of powerful active ingredients. By combining them with Physiomarine water, rich in active minerals, our researchers create natural, effective and sensorial cosmetics: Marine Cosmetics.
The island where it all begins
Located off France's Brittany coast, the island of Houat is a preserved environment, an ecological paradise. It is home to the Eclosarium, the Daniel Jouvance Marine Biology Research Centre. It is there, in this rare and unusual setting, that our scientists study microalgae. Respectful of natural reserves, we grow them from our own strains. From the nursery where we incubate them to the photoreactors where they are concentrated, we produce them exclusively for our products.
Our commitments
At Daniel Jouvance, marine cosmetics and respect for the environment go hand in hand:
© Groupe Rocher 2016


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About the Author
Brenda Herchmer has a diverse background gained in a variety of government, education, business, and voluntary sector settings. A writer, educator, consultant, and project manager, her primary work has involved organizational and community transformation and the change process, training, and leadership it requires. She has specialized in leadership development, adaptive planning, and recreation and community development. She is the owner of Grassroots Enterprises and the Campus for Communities of the Future (a social enterprise/micro college).
Brenda is an avid writer of both mainstream and academic material, a weekly newspaper columnist for 7+ years (Welland Tribune, Niagara Falls Review), and a regular blogger.
She is the author of three books: Leadership for Active, Creative, and Engaged Communities; A Planning Toolkit for Community Leaders; and Community Building for the Recreation Practitioner. Brenda was a recipient of the District 60 Toastmasters Communication and Leadership Award and was acknowledged as a YWCA Woman of Distinction in Training and Education.
Previously she has worked for Alberta Recreation and Parks Association, Niagara College, the City of Niagara Falls, and Brock University. While at Niagara College she founded and then managed the Niagara Centre for Community Leadership which was acknowledged by College and Institutes Canada (formerly ACCC) as an "exemplary practice in community development" and was a finalist for the Peter F. Drucker Voluntary Sector Innovation Award. Brenda was named the 2016 Brock University Distinguished Graduate Award for the Faculty of Applied Health Sciences and in 2017 was inducted as an Honourary Member, Golden Key International Honour Society.
While Brenda's experience is diverse, there is a common thread throughout - as a community builder she is committed to, and believes in, the importance and strength of our communities.Posted on 01-01-13 Commenting is not available in this channel entry.
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If you want to have your business presence online too, there are a number of options to do so. As a businessman with no skills or experience of designing or developing a website, you will need to look for somebody who could do that for you. Having a website for your small business in Dubai can boost up your sales. You might one day be able to see a big day in your small store due to online presence and performance. In order to be present and available for your customers and prospect customers online, you can take the services of an already present online platform. These are giant websites that accommodate a number of companies and their products on one page.
The person searching for a particular product can open the link of the giant website and can find the product/service of your company. On the same page, the same person can also find the same product being offered by your other three competitors. It makes it difficult for the consumer to decide which brand to select and similarly things get kind of difficult for your business as well. The giant website accommodating your business says that you need to stay with them and keep on making monthly payments directly through any PayPal or any bank account link. The option of streamlining business might just work for some lucky vendors and not for all. What if you are not getting enough revenues and still bind to make expensive pays to the giant website every month. It can get messy for you, especially when your business has just begun and you never were in this field before.
There is truly nothing like independence. The best option for you to make your online appearance is through an independent website that isn't associated with any giant platform. It is understandable that you might be having zero web designing experience and so you do need support. You can take support of a company that doesn't bind you to make monthly payments and doesn't put conditions of a percentage of shares from your revenues. You need Dubai eCommerce solutions that require only one time investment and then you can hold the reins of your smart horse as it continues to grow and gallop through increase in sales. Your business can continue to grow independently through one time investment on website development. However, you need to be sure that the company that you selected for making your website is offering a complete range of Dubai eCommerce solutions all in one place.
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December 2018


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Shanghai 5 from Charles Lanceplaine on Vimeo.
A fun, thoughtful piece about the local skateboard culture in Shanghai and what it means to navigate this mind-boggling, ever-changing city where the old and new collide. One sees why, in the words of one skateboarder, "It's great to be young in Shanghai."
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A hundred different problems can arise during a typical home sale or purchase. Good realtors solve these problems and anticipate them before they occur.
Buying or selling a home can be complicated and time consuming. A hundred different problems can arise during a typical transaction. Good realtors not only solve these problems for clients, they also anticipate such problems before they occur.
But not all realtors are good at what they do. Some are not as committed or competent as others, and their shortfalls can cause headaches and considerable financial losses for clients.
Here are five common ways a realtor can mishandle – or even destroy -- your home sale or home purchase.
1. Delaying or complicating access to the property for inspections and appraisals.
Both listing agents and buyer agents can be guilty of this.
Real estate purchase contracts usually require that a property inspection be completed by a certain deadline – typically seven to 10 days after the date of contract acceptance. An appraisal of the home is required and arranged by the buyer's lender as a condition of making the loan.
It's the listing agent's duty to help ensure that the property is accessible to the home inspector and the appraiser. The buyer's agent, meanwhile, must help the buyer arrange the property inspection, and make sure that any repair requests resulting from the inspection are submitted to the seller in the proper format by the established deadline.
Many real estate deals collapse due to inspection and appraisal issues. If the buyers and their agent miss the deadline for completing the home inspection and requesting repairs, the buyers can lose the right to ask the sellers to make the repairs as a condition of moving forward with the deal.
If you're buying a home, make sure your agent knows the specific date by which he/she must submit repair requests to the seller. Better yet, immediately after the contract offer is signed by both parties, ask your realtor when the property inspection will take place.
2. Failing to get completed paperwork to the mortgage lender on time.
Home buyers and their agents are responsible for getting certain information to the mortgage lender on time. Failure to provide complete and accurate information to the lender as requested can significantly delay or even wreck a deal.
One great example of this is when first-time home buyers use home buyer assistance programs to help fund their purchase. Some of these programs require that buyers complete coursework to receive their benefits.
Lenders usually require proof that this coursework is completed. Home buyers sometimes drag their feet on completing this work. Failing to complete a home buyer assistance course and provide appropriate documentation to the lender can unnecessarily delay or derail your home purchase.
To help avoid this and similar problems with red tape, ask your realtor what documents and forms must be submitted to the mortgage lender and when that information must be provided.
3. Handling a type of transaction they're unfamiliar with.
Some agents are better at handling certain types of real estate transactions.
Want to buy waterfront property? Then your agent should understand things like riparian rights and the proper mean-low-water-level for your boat.
What about buying a short sale? Does your agent use a short-sale negotiation service or does he "handle" all the mind-numbing administrative requirements himself?
Engaging a realtor to handle a transaction type he or she is unfamiliar with is setting yourself up for failure.
Consider short sales, for example. Every short sale is different, and there are key questions to ask.
For example, does the seller have one mortgage on the property or two? If there are two mortgages, does the same bank hold both mortgages, or are they owned by different banks? And which banks, in particular, hold those loans? Realtors that handle short sales know that certain banks are notoriously difficult to work with.
The answers to these questions can make a difference in whether you'll wait two months for an approval decision or nine months. Or even longer.
A good agent with experience handling short sales can set the proper expectations for you and streamline the purchase process to minimize the work and aggravation short sales entail.
The same holds true for other types of real estate transactions: investment properties, vacation properties, rent-to-owns, waterfront homes and the like.
Make sure your agent has experience with the type of property you're looking to buy.
4. Failing to promptly return phone calls, emails or text messages.
Buying real estate is an involved, high-stakes endeavor with many key players and critical deadlines. Problems crop up quickly and frequently. Consequently, transactions must be constantly monitored and nurtured by your realtor, and your realtor should keep you apprised of what's happening. This is especially true if you, as the buyer or seller, have not been through the process before.
The key to conducting any business of this magnitude is communication. The parties must have the ability to contact one another whenever necessary to clarify issues that arise.
In this day and age, people prefer to communicate in different ways, whether it be by phone, email or text message. You and your realtor should discuss this issue before signing a representation agreement. How often do you expect updates from your realtor? How quickly do you expect him or her to respond to your messages? What is your preferred method of communication?
It's one thing for your agent to leave town for a few days for a family vacation. But it's another thing if your agent doesn't return your messages and hasn't enlisted a qualified colleague to help you while he's away.
5. Failing to do proper research.
What if your agent helps you buy a home and after taking possession you learn that your HOA doesn't allow you to keep your dog?
What if you buy a home thinking it's located in a certain school district, but once you move in you find the home actually feeds into a different school?
Or, what if three months after placing a purchase contract on a short sale home you discover the seller will not pay to have the home's gas, water and electric service turned on for the property inspection?
In instances like these, more comprehensive research by the agent – along with due diligence by the client – can help prevent nasty surprises.
Realtors are not responsible for knowing everything about a home. But reputable, experienced agents tend to know more about the business and how to avoid the kinds of problems that can arise.
Seek out agents you can trust. Ask friends and relatives for referrals. Ask tough questions of your realtor before you engage his or her services.
Not all realtors are the same. As in any profession, some practitioners are better than others, and you want to work with the good ones.
Jerry Kline is a Realtor with the Odenton, Md., office of Keller Williams Flagship Realty (1216 Annapolis Rd., Odenton.) For more information on the local real estate market, contact him at (443) 924-7418, or visit his blog (www.JerryKlineRealtor.wordpress.com) or website (www.JerryKline.kwrealty.com).


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Assertive Community Treatment (ACT) Programs
Way Station's ACT Program provides services that are designed to meet the needs of individuals who are unable or unwilling to engage in traditional, facility-based outpatient psychiatric treatment and rehabilitation services.
ACT services are available 24 hours per day, seven days per week and are provided in community settings and at times that best address individual client needs.
The following mobile treatment services are provided to individuals at a frequency, intensity, and duration that addresses the needs of each individual served:
- Psychiatric Evaluation and Assessment
- Medication Administration and Monitoring
- Medical Psychotherapy
- Interactive Therapies
- Skill Assessment and Training
- Health Promotion and Training
- Crisis Intervention
- Support, Linkage, and Advocacy


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text:
- Research
- Open Access
Asymptotic structural properties of quasi-random saturated structures of RNA
- Peter Clote1Email author,
- Evangelos Kranakis2Email author and
- Danny Krizanc3
© Clote et al.; licensee BioMed Central Ltd. 2013
- Received: 3 October 2011
- Accepted: 21 September 2013
- Published: 25 October 2013
RNA folding depends on the distribution of kinetic traps in the landscape of all secondary structures. Kinetic traps in the Nussinov energy model are precisely those secondary structures that are saturated, meaning that no base pair can be added without introducing either a pseudoknot or base triple. In previous work, we investigated asymptotic combinatorics of both random saturated structures and of quasi-random saturated structures, where the latter are constructed by a natural stochastic process.
We prove that for quasi-random saturated structures with the uniform distribution, the asymptotic expected number of external loops is O(logn) and the asymptotic expected maximum stem length is O(logn), while under the Zipf distribution, the asymptotic expected number of external loops is O(log2n) and the asymptotic expected maximum stem length is O(logn/log logn).
Quasi-random saturated structures are generated by a stochastic greedy method, which is simple to implement. Structural features of random saturated structures appear to resemble those of quasi-random saturated structures, and the latter appear to constitute a class for which both the generation of sampled structures as well as a combinatorial investigation of structural features may be simpler to undertake.
- RNA secondary structure
- Kinetic trap
- combinatorial analysis
- Zipf distribution
RNA is an important biomolecule, now known to play both an information carrying role, as in retroviruses, such as HIV, whose genome consists of RNA, as well as a catalytic role, as in the the peptidyl transferase catalysis by RNA, which concatenates an amino acid to a growing peptide chain in the formation of a protein on the ribosome [1]. It has recently emerged that RNA plays a wide range of previously unsuspected roles in many biological processes, including retranslation of the genetic code (selenocysteine insertion [2], ribosomal frameshift [3]), transcriptional and translational gene regulation [4, 5], temperature sensitive conformational switches [6, 7], chemical modification of specific nucleotides in the ribosome [8], regulation of alternative splicing [9], etc.
The diverse and biologically important functions performed by RNA molecules depend for the most part on RNA tertiary structure, which is known to be constrained by secondary structure, the latter acting as a scaffold for tertiary contact formation [10]. For this reason, much work has focused on RNA secondary structure prediction [11–14] and on the kinetics of RNA folding [15–17]. In [18], Stein and Waterman pioneered work on asymptotic combinatorics of RNA secondary structures, where they developed recurrence relations to count the number of secondary structures. These recurrence relations were later modified by Nussinov and Jacobson [19] and especially by Zuker [20] to compute the minimum free energy secondary structure.
Formally, a secondary structure for a given RNA nucleotide sequence a1, …, a n is a set S of base pairs (i, j), such that (i) if (i, j) ∈ S then a i , a j form either a Watson-Crick (AU,UA,CG,GC) or wobble (GU) base pair, (ii) if (i, j) ∈ S then j - i > θ = 3 (a steric constraint requiring that there be at least θ = 3 unpaired bases between any two paired bases), (iii) if (i, j) ∈ S then for all j′ ≠ j and i′ ≠ i, (i′, j) ∉ S and (i, j′) ∉ S (nonexistence of base triples), (iv) if (i, j) ∈ S and (k, ℓ) ∈ S, then it is not the case that i < k < j < ℓ (nonexistence of pseudoknots). For the purposes of this paper, following Stein and Waterman [18], we consider the homopolymer model of RNA, in which condition (i) is dropped, thus entailing that any base can pair with any other base, and we modify condition (ii) so that θ = 1. With inessential additional complications in the combinatorics, we could handle the situation where θ is any fixed positive constant.
For a given RNA sequence, a saturated secondary structure is one such that no base pair can be added without introducing either a pseudoknot or base triple; in other words, saturated structures have a maximal number of base pairs, while the Nussinov minimum energy structure has a maximum number of base pairs. Since the kinetics of RNA structure formation depend on secondary structure energy landscape, and more particularly on the distribution of kinetic traps (saturated structures), in previous work we have designed an algorithm to compute the number of saturated structures [21], determine the asymptotic number of saturated secondary structures [22] and the expected number of base pairs in saturated and quasi-random saturated structures [23].
Secondary structures are conveniently displayed in Vienna dot bracket notation, consisting of a balanced parenthesis expression with dots, where an unpaired nucleotide at position i is depicted by a dot at that position, while a base pair (i, j) is depicted by the presence of matching left and right parentheses located respectively at positions i and j. The minimum free energy secondary structure of the selenocysteine insertion (SECIS) sequence fruA, given by
is a saturated structure. In contrast, the following structure for the Gag/pro ribosomal frameshift site of mouse mammary tumor virus [24] is not only not saturated, but includes a pseudoknot, as shown by the square bracket notation necessary to show the crossing base pairs.
Having defined saturated structure, we now define a stochastic greedy process to generate random saturated structures, technically denoted quasi-random saturated structures. This notion was defined in [23], where we showed that the expected number of base pairs in quasi-random saturated structures is 0.340633 · n, just slightly more than the expected number 0.337361 · n of base pairs in all saturated structures.
Results and discussion
With these definitions, we are now in a position to state some results concerning structural features of (quasi) random saturated structures. Under the uniform distribution, we show that the asymptotic expected number of external loops is O(logn), and the expected maximum stem length is O(logn). In contrast, under the Zipf distribution, the asymptotic expected number of external loops is O(log2n), and the expected maximum stem length is O(logn/ log logn)a.
In the literature on RNA combinatorics ([18] and subsequent papers), combinatorial results have been proved for the homopolymer as well as for the Bernouilli model, in which latter one assumes a stickiness parameter p = 2(p A p U + p G p U + p G p C ) that any two positions can base-pair. To the best of our knowledge, the current paper appears to be one of the first combinatorial analyses of RNA secondary structures, which involves the Zipf distribution for base pairs.
Saturated secondary structures form natural kinetic traps in the energy landscape with respect to the Nussinov energy model [19], in that it is energetically unfavorable to move from a saturated structure to any neighboring structure that differs by one base pair. However, there is currently no program to sample saturated secondary structures with respect to the Nussinov energy (given either a homopolymer or an RNA sequence), although the programs we developed in [21, 22] could be extended to do so for both homopolymers and RNA sequences. (Note that the program RNAsat, described in [25], can sample saturated structures in the Turner energy landscape, and the program RNAlocopt, described in [26], can sample locally optimal structures in the Turner energy landscape). In contrast, it is extremely simple to implement a program to sample quasi-random saturated structures, thus permitting one to easily obtain an idea of various structural features in the ensemble of quasi-random structures. We expect many structural features to be approximately shared between the random saturated structures and quasi-random saturated structures – for instance, as earlier mentioned, the expected number of base pairs in quasi-random saturated structures is 0.340633·n, while the expected number of base pairs in saturated structures is 0.337361·n, almost the same value [23].
Generally, it requires substantial effort involving the application of deep results from complex analysis, such as the Flajolet-Odlyzko theorem [27] or the Drmota-Lalley-Woods theorem [28–30] (see also the text by Flajolet and Sedgewick [31]) to prove asymptotic results, such as the fact that the asymptotic number of saturated structures is 1.07427 · n-3/2 · 2.35467 n and the asymptotic expected number of base pairs is 0.337361 · n, and the asymptotic expected number of hairpins is 0.323954 · 1.69562 n [23]. In contrast, the argument given in this paper is elementary, not requiring complex analysis. Taken together we believe that the stochastic greedy method, described in Figure 1, performs reasonably well in sampling saturated structures, that appear to be representative of the ensemble of all saturated structures, and supports a combinatorial analysis that may be simpler than that required for all saturated structures.
Structural properties of quasi-random saturated secondary structures
In general G(S) is a forest; i.e., a set of trees. In the sequel we determine the size of several structural parameters of random saturated secondary structures, in particular, expected stem length and expected number of external loops. These parameters are studied both for the uniform and Zipf distributions. Before proceeding any further, we first define the probability distributions to be considered.
Probability distributions
Zipf's law is the observation first made by the deceased Harvard linguist, George Kingsley Zipf, that the frequency p i of English words, when graphed against their rank i (in the list of English words sorted in decreasing order with respect to frequency), obeys the power law p i ≈ i - α. More generally, Zipf's law is the statement of a power law, when plotting frequency against rank (Zipf's first law) or when plotting frequency against reverse rank (Zipf's second law). In bioinformatics, Zipf's law has been observed in the frequency/rank plot of differentially expressed gene in microarray data [33], as well as in the frequency/rank plot for protein structures [34], where there are a few very frequent structures, and very many rare structures. In the remainder of the paper, we consider probability distributions related to Zipf's law.
for all n ≥ 2.
Observe that when α = 0 the α-Zipf distribution is the same as the uniform distribution, while if α = 1, we have the (classical) Zipf distribution [35]. Moreover, observe that as α increases, "shorter" base pairs are being selected with higher probability by the stochastic process described in equation (1).
The stochastic process of generating random saturated secondary structures, according to equation (1), is of the "divide-and-conquer" type, very common in computer science, where well-known algorithms such as QUICKSORT choose a division point according to the uniform distribution. Stochastic algorithms of this kind have been intensively studied for the uniform distribution. Known results suggest that the probability distribution for the number of base pairs in random saturated structures, generated by the earlier described stochastic process (uniform choice of base pairs) is asymptotically Gaussian (see [36] and [37]). We also note that structural features of trees have been well studied including the expected depth and the exact distribution of the depth; see, for instance, [36, 38, 39]. In the sequel, we consider a random binary search tree with n nodes obtained by inserting n i.i.d. random variables X1, …, X n . Careful analysis of [36] and [39] implies our results in the section on the uniform distribution. However we will use a different and simpler technique that enables the analysis not only for the uniform distribution in the following section concerning the Uniform Distribution, but also for the Zipf distribution in the section following this section.
An important observation concerns the threshold θ considered above. All the results proved in this section are "upper bounds" and therefore it is easily seen that they are valid for any threshold θ ≥ 0. Therefore to simplify proofs in the sequel we consider the case of threshold θ = 0.
Uniform distribution
The main theorem of this section concerns stem length and number of external loops of random saturated structures S, generated by a natural stochastic process associated with the tree graph G(S). Throughout the remainder of the paper, we state results in terms of random saturated structures, although we intend to mean only those structures generated by the stochastic process associated with the graph G(S); we will distinguish between the uniform and α-Zipf variant of the stochastic process. Without this convention, statements of lemmas and theorems would be too cumbersome.
Theorem 1. With high probability, the number of external loops and the maximum stem length of random saturated structures generated by the uniform distribution variant is O(logn).
Proof. Before we give the proof of the main theorem it will be necessary to give the proof of two lemmas. In the first lemma we consider the expected number of external loops.
Lemma 1. With high probability, the number of external loops is O(logn).
where the last inequality is valid for k + 3 ≤ n.
In particular, . This completes the proof of Lemma 1. □
Next we prove the following lemma.
Lemma 2. With high probability, the maximum stem length is O(logn).
(notice the dependence of the random variable T′ on n).
In particular, since , we conclude that . Finally, we can derive It follows that
As a consequence we conclude that This completes the proof of Lemma 2. □
Finally, we can complete the proof of the main result of Theorem 1 since this is now immediate from Lemmas 1 and 2.
Zipf distribution
is defined to be the (n - 1)st harmonic number. As before, the chord joining 1 and u partitions the ring into two parts. One part has k bases between 1 and u, where k ≤ n - 2, and the other part has the remaining n-k-2 bases (see Figure 1).
Define Z n to be the expected number of base pairs of a random saturated secondary structure with n bases, where n ≥ 2. A base pair (1, u) is added as follows. Select u ≥ 2 at random among 2, 3, …, n with probability .
for all n ≥ 2. The main theorem of this section concerns the overall structure of random secondary structures.
Theorem 2. With high probability, random saturated secondary structures generated by the Zipf distribution have O(log2n) external loops and stem length O(logn/ log logn).
Proof. Before we give the proof, it will be necessary to give the proof of two lemmas. In the first lemma we look at the number of external loops.
Lemma 3. With high probability, the number of external loops is O(log2n).
In particular, since H(n - 1) ∼ lnn we conclude that This completes the proof of Lemma 3. □
The next result concerns the maximum stem length. We can prove the following result.
Lemma 4. With high probability, the maximum stem length is O(logn/ log logn).
(notice the dependence of the random variable T′ on n).
The proof shows that the leftmost sequence of base pairs given by the recursive construction of the random secondary structure has length at most O(logn/ log logn) with high probability. We would like to prove the same for any sequence of nested base pairs. It is easily seen that a proof similar to the one presented above works. This completes the proof of Lemma 4. □
If we now combine Lemmas 3 and 4 we derive the proof of Theorem 2.
a Throughout this paper all logarithms are in base 2.
Many thanks to the anonymous referees for useful comments that improved significantly the presentation.
Funding for the research of P. Clote was provided by National Science Foundation grant DMS-1016618. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation. Additional support was provided to P. Clote by the Deutscher Akademischer Austauschdienst (DAAD) during a visit to the Computational Molecular Biology Department of Martin Vingron, at the Max Planck Institute for Molecular Genetics. Funding for the research of E. Kranakis was provided by the Natural Sciences and Engineering Research Council of Canada (NSERC) and Mathematics of Information Technology and Complex Systems (MITACS).
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