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text:
Fate Therapeutics Announces Encouraging Dose-Escalation Clinical Data of FATE-NK100 and Provides Regulatory Update on Landmark IND Application for FT500
NK100 Shows Clinical Benefit in Treating Advanced Hematologic Malignancies and Solid Tumors
Disease Control Shown in All Subjects Re-treated with Second Dose of NK100
No NK100-related Dose Limiting Toxicities Reported
Submitted Data to FDA Demonstrating FT500 Master iPSC Bank is Free of Adventitious Agents
Twenty heavily pre-treated subjects, each presenting with progressive disease at the time of enrollment, have been treated with FATE-NK100 in the dose-escalation phases of three Phase 1 clinical trials. As of a
- In the DIMENSION study for the treatment of advanced solid tumors (n=5 in the monotherapy regimen; n=1 in the monoclonal antibody combination regimen1), one subject at the second dose level (1-3x107 cells per kg) and two subjects at the third dose level (3-10x107 cells per kg) treated with a single intravenous infusion of FATE-NK100 in the monotherapy regimen had stable disease at one month. These two subjects at the third dose level were each subsequently treated with a second dose of FATE-NK100 and remain on study (3.1 and 5.0 months, respectively) with ongoing disease control. The study is currently enrolling at the third dose level in the monotherapy regimen, at the second dose level in the cetuximab combination regimen (1-3x107 cells per kg) and at the run-in dose level in the trastuzumab combination regimen (1x106 cells per kg).
- In the APOLLO study for the treatment of recurrent ovarian cancer (n=4), one subject treated with a single intraperitoneal infusion of FATE-NK100 at the second dose level (1-3x107 cells per kg) had stable disease at one month. The subject was subsequently treated with a second dose of FATE-NK100 and maintained disease control for 6.2 months. The study is currently enrolling at the third dose level (3-10x107 cells per kg).
- In the VOYAGE study for the treatment of refractory or relapsed acute myelogenous leukemia (n=4), all three subjects treated with a single intravenous infusion of FATE-NK100 at the second dose level (1-3x107 cells/kg) showed complete clearance of leukemic blasts in the bone marrow and achieved a morphologic leukemia-free state at Day 14 following treatment. Each of these three subjects received a single dose of FATE-NK100 only, and the anti-leukemic response in each of these subjects was transient. The study is currently enrolling at the second dose level.
No dose limiting toxicities related to FATE-NK100 were reported. One serious adverse event related to FATE-NK100 was reported (Grade 3: abdominal pain) in the APOLLO study.
"The safety and clinical benefit observed with a single infusion of FATE-NK100 as a monotherapy in heavily pre-treated cancer patients, including in refractory AML patients that have high leukemic blast burden in the marrow and in advanced solid tumor patients with progressive disease, are encouraging," said
In addition, the Company announced that adventitious agents testing of the master iPSC bank for the clinical production of FT500, a universal, off-the-shelf NK cell product candidate, has been completed. The FT500 master iPSC bank was found to be free of adventitious agents as determined by in vivo and in vitro testing. The Company has submitted these results to the
An updated presentation on the Company's NK cell cancer immunotherapy franchise can be found under "Events & Presentations" in the Investors and Media section of the Company's website at www.fatetherapeutics.com.
1 Excludes one subject treated at the run-in dose level in the cetuximab combination regimen (1x106 cells per kg)
About FATE-NK100
FATE-NK100 is an investigational, first-in-class, allogeneic donor-derived natural killer (NK) cell cancer immunotherapy comprised of adaptive memory NK cells, a highly specialized and functionally distinct subset of activated NK cells expressing the maturation marker CD57. Higher frequencies of CD57+ NK cells in the peripheral blood or tumor microenvironment in cancer patients have been linked to better clinical outcomes. In
About Fate Therapeutics' iPSC Product Platform
The Company's proprietary iPSC product platform enables mass production of off-the-shelf, engineered, homogeneous cell products that can be administered in repeat doses to mediate more effective pharmacologic activity, including in combination with cycles of other cancer treatments. Human iPSCs possess the unique dual properties of unlimited self-renewal and differentiation potential into all cell types of the body. The Company's first-of-kind approach involves engineering human iPSCs in a one-time genetic modification event, and selecting a single iPSC for maintenance as a clonal master iPSC line. Analogous to master cell lines used to manufacture biopharmaceutical drug products such as monoclonal antibodies, clonal master iPSC lines are a renewable source for manufacturing cell therapy products which are well-defined and uniform in composition, can be mass produced at significant scale in a cost-effective manner, and can be delivered off-the-shelf to treat many patients. Fate Therapeutics' iPSC product platform is supported by an intellectual property portfolio of over 100 issued patents and 100 pending patent applications.
Forward-Looking Statements
This release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995 including statements regarding the advancement of and plans related to the Company's product candidates and clinical studies, the therapeutic potential of the Company's NK cell cancer immunotherapies, including FATE-NK100 and FT500, the Company's regulatory strategy, and the Company's plans for its intended clinical investigation of FATE-NK100 and FT500. These and any other forward-looking statements in this release are based on management's current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to, the risk of difficulties or delay in the initiation of any planned clinical studies, or in the enrollment or evaluation of subjects in any ongoing or future clinical studies, the risk that the Company may cease or delay preclinical or clinical development of any of its product candidates for a variety of reasons (including requirements that may be imposed by regulatory authorities on the initiation or conduct of clinical trials or to support regulatory approval, difficulties in manufacturing or supplying the Company's product candidates for clinical testing, and any adverse events or other negative results that may be observed during preclinical or clinical development), the risk that results observed in prior clinical trials or preclinical studies of FATE-NK100 or FT500 may not be replicated in ongoing or future clinical trials or studies, and the risk that FATE-NK100 or FT500 may not produce therapeutic benefits or may cause other unanticipated adverse effects. For a discussion of other risks and uncertainties, and other important factors, any of which could cause the Company's actual results to differ from those contained in the forward-looking statements, see the risks and uncertainties detailed in the Company's periodic filings with the
Stern Investor Relations, Inc.
Source: Fate Therapeutics, Inc.

subset: commoncrawl


text:
Glancing nervously out a window in this border city, [North Korean refugee] Kim Jong-chol said he'd commit suicide if the police threatened him with repatriation.
"I have no choice if I'm arrested. I can't go back to North Korea now," Kim said, explaining that he'd confront criminal charges, and probably execution, as someone who'd fled to China twice before, been caught both times and forcibly repatriated.
Asked to explain what life is like in his homeland, Kim said quietly: "You will never understand what I'm telling you. It's such a miserable situation." Kim, a farmer, said his family's home had no indoor plumbing. In winter, there was never enough heat. For most people, food supplies are inadequate. The children always ask for more food, Kim said, describing the daily diet as mostly boiled or mashed corn. Electricity was on for three hours a day at most, and the family had to fetch water from far away.
"Rice rations have stopped, and there's no guarantee you can get your wage," Kim said. Any criticism of the regime is kept to very intimate friends or family. "Many people disappear for making the wrong remarks," he said.
Kim said he hoped to reach a safe area outside China, then "I will work like a slave to earn money to bring my wife and children out of North Korea."


text:
The historic Old Alton Bridge, which connects the towns of Denton and Copper Canyon, has a complex and haunted history. From tragic and riveting tales of murder to the somewhat vague stories of a ghostly goatherder, it's sure to give you the chills if you ever visit – heading out there after dark probably isn't advisable, in any case!
Goatman's Bridge: History & Hauntings of Denton's Old Alton Bridge
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Wikimedia Commons/Brianchester666
The bridge was built in 1884, by the King Iron Manufacturing Bridge Company. Its original purpose was to carry horses and automobiles across the river. Though it is called the "Old Alton Bridge" the community of Alton had already dispersed by 1884. Denton County itself was formed in 1846, and the first attempt at settling the county seat was Pinckneyville (named for the Texas governor). However, water shortages forced politicians to move two years later, in 1848. The new townsite was located on a high ridge between Pecan Creek and Hickory Creek and was called Alton.
Their luck with this second townsite was also short-lived; in 1850 they moved once more, to a location five miles from present-day Corinth. This attempt was more successful. The Hickory Creek Baptist Church was organized in 1855, and by 1856, there were several buildings including a school and a saloon. However, the county seat was moved once more in 1857, to Denton. The post office closed forever in 1859. Today, the Baptist Church and the Alton cemetery are all that remains of the Alton village. The bridge was built twenty-five years later and dubbed the "Old Alton Bridge."
Wikimedia Commons/Pixelsyndicate
It didn't earn the "Goatman" title until half a century later, when an African-American named Oscar Washburn settled in the area. His living was raising and selling goats. He was successful, and most of the community was supportive and friendly toward Washburn and his family, but unfortunately, the local Ku Klux Klan was not so pleased. Washburn posted a sign on the bridge which read "this way to the Goatman's." This action angered members of the Klan, and on a fateful night in August of 1938, they drove their cars across the bridge with their headlights off, took Washburn from his home and family, and dragged him to the bridge. The legend goes that they then fitted a noose over his head and threw him over the side of the bridge – but when they looked to see whether he was dead, his body had disappeared. They returned to his home and slaughtered his family, according to the legend. Washburn was never seen or heard from again – or was he?


text:
Free kick (U13-14 activity)
in EasiCoach
Set up a free kick situation in front of goal, but not in the penalty area. You will need a player to take the kick. Put three defending players between the ball and the goal. MORE
Free-kicks are important: fact. So important that between 40 and 50 per cent of all goals scored originate from set-pieces. And it's clear from the pros that practice makes perfect.
Gareth Bale has scored some fantastic free kicks for Wales and Real Madrid – when Ronaldo allows him to take them of course!
Bale says: "I practise my free-kicks after every session, for between half an hour and an hour."
But often in youth soccer you may not be the tallest team. Crosses, or even chips from central areas into the box are of little benefit. But by being switched on, your players can still make the most of attacking freekicks.
Practice some creative ones that don't involve crossing the ball – ones that are played on the ground behind the defence. Look at Barcelona: always first to the ball, always in position, looking to thread a quickly taken free-kick to a team-mate in a dangerous position.
As with shooting, preparation and practice are key to turning free-kicks into goals. You don't always need to set up a free kick to practice quick movements to score a goal.
These two sessions are great to help develop a player's free kick technique from this activity and game
These two tactics can give you good options for ideas to build on if your team finds it difficult to head the ball
Or if you have a great kicker of the ball you can shoot like Bale
And if your team can create from crosses with headers or volleys try these


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text:
Nicely symmetric idiom:
The verb quiet can be used as a causative, with or without the particle down. Some examples from the web:
Without down:
- Shut Up and Play 9 summer apps that will quiet your kids. (source)
- It'll help calm and quiet your kids, before they settle down to sleep. (source)
With down:
However, only with down can quiet be used as an intransitive verb with a reflexive interpretation.
(6) is ungrammatical on any reading, whereas (5) is grammatical only on the reading 'I decided to quiet myself down'. Why is the particle down important here? In my dissertation (chs. 4 and 5), I proposed that certain argument positions introduced by prepositions and particles can be left unsaturated in a way that leads to a reflexive interpretation. Direct objects without a preposition, particle or small clause of any kind are special; following work by Alec Marantz, such direct objects are not arguments in the same sense as external arguments, applied arguments, or the subjects of small clauses, but are incorporated more directly into the verb's event structure. That is, the direct object in (1-2) doesn't have the same status as the direct object in (3-4); in (3-4), the object is a thematic argument of the particle down. This is the sort of argument that can be left semantically unsaturated, such that it forms a complex predicate where the external argument gets two theta-roles in (5).
Of course, there are intransitive verbs like wash, which seem to be intransitive with a reflexive interpretation. Why isn't a particle important for these verbs?
One possibility is that verbs of the sort in (8) are primarily interpreted as activities, with the causative-result being inferred but not entailed. However these verbs are built and interpreted, the particle is necessary for the event structure to entail a reflexive causative-result. Since a verb like quiet in (1-6) names a result and not an activity, it requires a particle in order to be interpreted as an intransitive reflexive, ruling out (6) in contrast to (8).
Very interesting construction– here you have a body-part prefixed to a verb like "break" (e.g. "he arm-broke"). At some point, I'd love to study structures like this from the perspective of inalienable possession structure(s) cross-linguistically. But I wouldn't mind if someone beat me to it :-)
- Fara á skíði (hef ekki gert það síðan ég handleggsbraut mig 9 ára). (source)
- Talið er að hann hafi handleggsbrotnað. (source)
Note in (2) the intransitive –na form brotna 'break' is used, whereas in (2) the transitive form brjóta 'break' is used with a reflexive object in the accusative case. The transitive form can take a non-reflexive object as well. For example, (3) is a headline in an online newspaper; (4) comes from the body of the same article, and uses the intransitive form.
- Handleggsbraut kennarann sinn. (source)
- 14 ára nemandi í Hvaleyrarskóla í Hafnarfirði hrinti kennara sínum í síðustu viku með þeim afleiðingum að kennarinn handlegs- og hryggjarliðsbrotnaði.
The example in (4) also shows (i) coordination of the prefixed body part and (ii) another bone other than 'arm'. A brief google search leads me to suspect that this is a fairly productive construction, in terms of its applicability to various body parts, but I haven't confirmed this.
(Does hryggjarliður refer to "spine" or "vertabra"? The article doesn't seem to imply that the teacher was hurt as badly as would be implied by the English sentence Her back broke or She broke her back.)
A waitress at a casino was passing out drinks, and a couple of dollar bills fell into a beer. The waitress said that she would get another beer, since the money clearly contaminated it. Referring to the money, she said, very fluidly, "Think of where it could've and probably was," an ungrammatical sentence to me and no doubt many others as well, but maybe not an entirely unprincipled speech error.


text:
F.J. Raymond is credited with saying, "Next to being shot at and missed, nothing is quite as satisfying as an income tax refund." While this may be a bit of an exaggeration it is true that a large tax refund can make you feel like Christmas came twice.
Nobody takes great pleasure in filing income tax forms. But if you use discretion and fill those forms out strategically, you could be rewarded with a handsome tax return for your efforts. The first, and most important, step is knowing which tax forms you need to fill out. Many people find these forms intimidating, frustrating, and more difficult to decipher than stereo instructions. But knowledge is power, so let's take a look at the different tax forms and discuss when it is appropriate to use them.
The Long and Short of It
- 1040EZ (very short form)
This is by far the shortest and most straightforward of the income tax forms. But don't allow yourself to be too drawn in by its simplicity – it can only be used by people who fulfill a number of requirements including having less than $100,000 total annual income, less than $1,500 total interest income, under 65 years of age, no income adjustments, and income that stems exclusively from wages, interest, or unemployment. Using 1040EZ also only allows you to claim the standard deductions and the Earned Income Credit. Therefore, this form is short and sweet, but usually won't maximize your deductions.
- 1040A (short form)
The vast majority of American taxpayers can use form 1040A. This form still requires that your total annual income be less than $100,000 but all other areas are more flexible than the 1040EZ. For instance, you can be any age, any filing status, have income from a variety of sources like Social Security benefits and IRA, claim certain income adjustments, and claim tax credits such as the child tax credit or education credits. Form 1040A gives you more flexibility in filing. However, it is very important to note that you cannot itemize your deductions in this form.
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By following these tips and soliciting the advice of a tax attorney, you will be able reap the benefits of a better refund.
Written by Randy Otis of Levy Tax Help.


text:
Jeffrey Pfeffer
People are often cognitively lazy, not just cognitively biased. Our mental shortcuts and unconscious patterns of thought make everyone susceptible to the tactics of interpersonal influence: tactics that depend on the norm of reciprocity, accepting and obeying authority (or its symbols), the power of liking, the value created by scarcity, and the tendency to escalate levels of commitment, even in the face of negative outcomes. … [ Read more ]
Content: Quotation | Author: Jeffrey Pfeffer | Source: McKinsey Quarterly | Subjects: Influence, Organizational Behavior, Personality / Behavior, Persuasion
Jeffrey Pfeffer
When executives tell me that flattery doesn't work and that people can see through strategic efforts to garner their support, I cite extensive evidence showing that we are generally quite poor at discerning deception. When the deception is coming from a master deceiver and consummate politician like [Lyndon] Johnson, the odds of successful resistance are quite low.
Content: Quotation | Author: Jeffrey Pfeffer | Source: McKinsey Quarterly | Subjects: Influence, Organizational Behavior, Personality / Behavior, Persuasion
James E. Lukaszewski
Here's a test of your current level of influence in your organization. Do people hold up meetings, waiting for you to arrive to make important contributions or interpretations of current events? Do people remember what you say and perhaps quote you in other places and venues? Do people tell your stories and share your lessons as though those stories belong to them? Do people learn … [ Read more ]
Content: Quotation | Author: James E. Lukaszewski | Source: Leader to Leader | Subject: Influence
Ralph Szygenda
There are two thoughts that often get lost in the discussion about being effective in building and using influence: Don't assume you have all the right answers-that's why a strong team is essential. And, above all, do the right thing-not only for business or economic impact, but also for social and philosophical implications. Ultimately, power is the ability to influence and facilitate change, and people … [ Read more ]
Content: Quotation | Source: Optimize Magazine | Subjects: Influence, Power / Authority
Dale Carnegie
The only way on earth to influence… [someone] is to talk about what he [she] wants and show him [her] how to get it.
Content: Quotation | Source: MarketingProfs | Subjects: Influence, Persuasion
E. M. Forster: Howard's End
Don't ask for power. Seek influence. It lasts longer.
Content: Quotation | Subjects: Influence, Power / Authority


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Nursing Assistant / NAC – Hawthorne, CA
We have a new employment opportunity for a Nursing Assistant / NAC / CNA in a long-term care / skilled nursing facility (LTC / SNF) in Hawthorne, California. This respected nursing home company values the opportunity to help every resident make the most of each day. Prior SNF experience strongly preferred. Multiple positions and shifts available, contact us today!
Nursing Home Certified Nursing Assistant / CNA responsibilities:
Maintaining resident confidentiality at all times
Positioning and proper alignment using pressure ulcer prevention techniques
Promptly responding to call lights
Bathing, showering, and feeding residents
Assisting resident in ambulation
Safely using wheelchair, walkers, mechanical lifts and scales
Documenting I&Os
Assisting with resident hygiene; grooming activities, oral and hair care
Recording vital signs and weights
Assisting residents to and from the bathroom/commode
Using appropriate transfer techniques and/or Hoyer lift
Monitoring resident blood pressure & temp
Nursing Assistant / CNA qualifications:
Current State Nursing Assistant Certificate (NAC) required
CPR / BLS certification
Competitive benefits for full time employees!
Executive Search Solutions is a national recruitment firm with a long-term care focus. Our clients include Skilled Nursing Facilities (SNF) / Nursing Homes, Assisted Living and Independent Living centers, Continuing Care Retirement Communities (CCRC), Rehab, Hospice, and Home Health Agencies.
Please click apply now, email email@example.com, or fax resume to 877-685-8779 to be considered for this Skilled Nursing Facility Certified Nursing Assistant / CNA / NAC opportunity in Hawthorne, CA. We look forward to hearing from you!


text:
The Once and Future King looked around his realm, to see his knights standing close by and his beloved overjoyed at his return. But Lancelot was not there. Nor was his beloved Guinevere there to cleave him. A horrific world moved about him, a world so futuristic the King fell to his knees in awe.
While he did not know it, the 31st century whizzed by his ancient being. Lanterns flashed unnatural colours. Horseless carriages flew through the air. The tongues of far of lands were shouted at him from passersby. The smells that overwhelmed him were so sweet, so new.
That was the first familiar thing that had happened since his resurrection. The thought hit him like a lance to the chest. If he hadn't already been on his knees, he would have dropped. He recalled the words "future" and "again" while his eyes closed for the last time, but didn't perceive what was being said. What had Merlin done? What magick had brought him here?
He stood to his feet, glancing back and forth for the voice that called him. He stood a foot above those shoving past him. Their gaze never meet his own, as if he was a ghost to them. What was this place that he had been called to?


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View Changes to a Configuration Template
When you push a template configuration to a device, you can view changes between the old and the new configuration template. To view changes made to a configuration template, use the vManage Monitor ► Audit Log screen.
- Select the audit log row from the table. The Message column of the audit log row will contain a message to the effect that the template is successfully attached to the device.
- Click the More Actions icon to the right of the row and click CLI Diff.
The CLI Diff popup window opens, with the Config Diff tab selected by default. This window displays a side-by-side view of the differences between the configuration that was on the device and the changes made to the configuration. To view the changes inline, click the Inline Diff button located to the right of the window.
To view the updated configuration on the device, click the Configuration tab located to the left of the window.
Release Information
Introduced in vManage NMS in Release 15.2.
Additional Information
Export Audit Log Data in CSV Format
Set Audit Log Filters
View Audit Logs


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Agni is the body fire, which is responsible for transformation of one substance to another. It breaks down the food substances, eliminates toxins and wastes, maintains body temperature, and resists the invasion of microbes by maintaining strong body immunity. The body fire which is assisted by balanced doshas digests the food completely to form Pakwa Anna rasa (the liquid form of food which is completely digested by digestive enzymes) which is ready to get absorbed by body tissues. According to ayurveda Pakwa Anna rasa nourishes the body and its components to keep the body devoid of diseases. But when body fire is impaired there will be an incomplete digestion of food forming Apakwa rasa (indigested food). The indigested food fails to nourish the body components leading to lowered body resistance.
Herpes is caused by a virus the herpes simplex virus ( HSV) which belongs to the same family of viruses that cause chickenpox. There are two types of herpes simplex viruses.
- herpes simplex type 1 (HSV-1) and mostly causes oral herpes
- herpes simplex type 2 (HSV-2). And mostly causes genital herpes
However, both type-1 and type-2 can occur in the genitals, oral area or both.
Due to unhealthy life styles and diet , the delicate balance between doshas get disturbed. This disturbs the body fire or agni .
The disturbed agni fails to digest the food and toxins accumulated in body due to improper metabolism.
Accumulation of toxins reduces the body immunity and paves the way for invasion by microbes.
When a person who has low immunity comes in contact with HSV virus, he/she gets the genital herpes (HSV-2) or oral herpes. (HSV-1)


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Mystic Lake Center is a 70,000-square-foot event center and a 180-room hotel tower featuring 18 new suites with scenic views. Combining this expansion project with the existing Mystic Lake Casino Hotel makes it the second-largest in the Minneapolis-St. Paul area. Empirehouse entered into design-assist services with PCL Construction to assist with budgeting, pre-engineering, and the design layout anchoring of the saw-tooth curtainwall attachment.
Owner: Shakopee Mdewakanton Sioux Community
General Contractor: PCL Construction
Architect: Worthgroup Architects & Designers
Architectural Glass & Glazing Contractor: Empirehouse
Total Glass Area: Approx. 42,000 square feet
On-Site Pre-Glazing
Entering the project at the beginning of the design phase helped Empirehouse utilizes its Project Managers, Field Superintendents, and Glazing foreman to come up with an innovative on-site pre-glazing plan. It worked to doubled efficiency and reduced equipment costs and lift-related injuries for the nine-story hotel tower featured approx. 25,000 square feet of 6″ curtainwall assemblies glazed with high-performance glass. Empirehouse also participated in enclosure meetings early on with other Project Managers to hash out critical details on the exterior skin of the building prior to field mobilization, and a full-sized mockup was created to ensure system constructability.
After the Empirehouse production team fabricated the aluminum frames and delivered them to the job site, Empirehouse Glaziers set up two staging areas to pre-glaze curtainwall sections on site. When one section was pre-glazed it was hoisted to the opening by a custom picking beam and Spyder Lift Crane and installed by a team of Empirehouse Glaziers as the other curtainwall section was being pre-glazed on the second stage. After the first unit was installed, an Empirehouse foreman folded up and transported the Spyder Lift Crane above the second staging area to crane the other pre-glazed curtainwall unit to the opening for installation. It was a quicker approach than setting each frame separately using a swing stage to set the frames and glass into place. It also reduced equipment costs and kept the field crew productive with little downtime. In addition, Empirehouse utilized the Spyder Lift Crane to do the heavy lifting of other items like setting steel-loaded curtainwall mullions. This paid dividends in time savings as well as eliminating lift-related injuries.
Teamwork and Creative Glazing
In order to meet the Mystic Lake Center project Super Bowl deadline, our Field, Fabrication, and Project Management Team applied creative glazing and installation strategies to accomplish more work safely in less time. Empirehouse field team members utilized innovative pre-planning, teamwork, and creative glazing when they brought together a choreographed dance of three boom lifts and 12 Glaziers to install 190 glass lites into the facing hotel tower curtainwall on a sunny, summery Saturday.
During the week, glass units were crate dollied and skip stationed to each floor opening in preparation for installation. Then on Saturday, three teams of two Glaziers worked from the boom lifts and three teams of two Glaziers were stationed inside the building. One team prepped glass units, the second team set glass units, and the third team bolted frames. Working this way saved the time of moving the boom lifts up and down nine stories. Care was taken in coordination and planning so that there wasn't a lift installing glass units over another glazing team to ensure safety on site.
In all approx. 3,500 square feet of glass lites were safely installed by the Glazing Team in one day!
Video: 3,500 square feet of glass installed in one day
Installing Electrochromic Smart Glass
The "swoosh" curtainwall lining the event center of the Mystic Lake Center project offered challenges of another kind. Approx. 10,000 square feet of 10.5″ curtainwall assemblies were glazed with Sage electrochromatic smart glass. This state-of-the-art programmable glass automatically tints as the sun moves across the sky. Hotel and event guests can enjoy uninterrupted scenic views without the sun's glare, while it provides a comfortable controlled climate by blocking heat-gain during the summer months which reduces cooling costs. To make this electrochromatic smart glass function properly, each unit needed to be carefully wired, tested, and glazed perfectly into a unique frame location. This required an organized communication strategy. Project Assistant Rachel Yechout created an elevation to relay Sage wiring instruction procedures to the Fabrication and Installation Teams as they tested each glass tag.
Architectural glass and metal scope:
- Approx. 25,000 square feet of Kawneer 1600UT champagne anodized 2.5″ x 6″ fully captured ultra-thermal curtainwall assemblies glazed with 1″ Viracon VS6-08 blue-green tinted high-performance low 'e' coated glass and ceramic frit at spandrel
- Approx. 10,000 square feet of Kawneer 1600UT champagne anodized 2.5″ x 10.5″ fully captured ultra-thermal curtainwall assemblies glazed with electrochromatic Sage glass
- Approx. 7,000 square feet of Kawneer 451UT champagne anodized center-pocketed, flush-glazed storefront framing assemblies including 1.75″ x 4.5″ non-thermal framing systems glazed with 1/4″ clear tempered glass and 2″ x 4.5″ ultra-thermal framing systems glazed with electrochromatic Sage glass
- 25 aluminum thermal and non-thermal entrances
- Approx. 128 lineal feet of structural glass balustrade railing at stairs, overlook, and exterior patio
- Shower doors and mirrors for 180 hotel rooms and suites
- Borrowed lites
- Suite glass shelves
Thanks to teamwork, innovative problem solving, and going above and beyond, the Mystic Lake Center was successfully completed safely and in time for 2018 Super Bowl guests.
For your next project, trust a Certified NACC Architectural Glass & Metal Contractor for quality results. Contact Empirehouse at 763-535-1150 or contact us.
Photo Gallery: (Click to enlarge)


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MP VYAPAM Samvida Shikshak Bharti 2018 for 41000 Vacancies (मध्यप्रदेश व्यापम में संविदा शिक्षाक के 41000 पदों की भर्ती 2018)
MP VYAPAM Samvida Shikshak Bharti 2018 for 41000 Vacancies (मध्यप्रदेश व्यापम में संविदा शिक्षाक के 41000 पदों की भर्ती 2018): The Madhya Pradesh Professional Examination Board (MPPEB) is very soon likely to release its Notification in respect of Samvida Shikshak (SS) Bharti 2018 for the Grade-I, II & III on the Contractual Basis for appointments at MP State in the official website: http://www.vyapam.nic.in/. Those job seekers who are looking for the Shikshak jobs in the Madhya Pradesh state then they will apply online application form when it will start from the official portal very shortly.
The Madhya Pradesh Professional Examination Board (MPPEB) is also Known as MP Vyapam through its Advertisement will be invited Online Applications from the UR / OBC / SC / ST Candidates for Recruitment of the Samvida Shikshak (संविदा शिक्षक) Bharti for the Varg-1, 2 & 3 on contract basis very quickly through the official website. Candidates submit their Online application form 2018 for First Grade, Second Grade and Third Grade Samvida Shikshak Recruitment 2018 on or before the last date of submission from the website as stated.
MP VYAPAM Samvida Shikshak Bharti 2018: Details
Organization (संगठन): Madhya Pradesh Professional Examination Board (MPPEB)
Total Vacancies (रिक्त पदों की संख्या): 41000 Posts
Post Name (पद का नाम ): Samvida Shikshak (संविदा शिक्षक)
Post Grade (वर्ग): Varg-1, 2 & 3
MP VYAPAM Samvida Shikshak Bharti 2018: Eligibility Criteria
Educational Requirements (शैक्षिक योग्यता ):
Samvida Shikshak Varg -I: The Candidates Should Have Post graduation degree in the concerned subject from recognized University with B.Ed Degree qualification.
Samvida Shikshak Varg -II: The Candidates Should Have Graduation Degree and Two-year Diploma in elementary education (D.El.Ed) Or Graduate with 50% marks in concerned subject and B.ed or Higher Secondary (10+2), with 50% marks and B.El.Ed in elementary education.
Samvida Shikshak Varg -III: The Candidates Should Have Higher secondary (10+2) with 50% marks and the Two-year diploma in elementary education or B.El.Ed Degree in Elementary Education from recognized Board or University.
Age Limit (रोजगार में आयु सीमा):
Candidates must have age limit Between Minimum 21 years & Maximum 35 years as the advertisement notification. (उम्मीदवार की आयु कम से कम 21 वर्ष एवं अधिकतम 35 वर्ष).
MP Samvida Shikshak Application Form 2018
Application Fee:
- For Unreserved (UR) category, the fee should have of Rs. 400/- + 70 Rs Online portal charges.
- For Reserved categories like SC/ST/PWD shall be pay of Rs. 200/- with 70 Rs Online portal charges.
Candidates Shall have submit the examination fee through the Net Banking, debit card or credit card. No other mode of payment will be accepted. After once making payment nobody can take refunded the paid amount under any circumstance.
Important Dates
|Starting of online application forms
|28 February 2018 (Tentative)
|Last date for receiving filled applications
|27 March 2018
|Online Admit Card Publish Date
|15 days before the Examination
|Display of Schedule of Exam for Samvida Shikshak Grade – I
|19 June 2018
|Display of Schedule of Exam for Samvida Shikshak Grade – II
|17 July 2018
|Display of Schedule of Exam for Samvida Shikshak Grade – III
|31 July 2018
Selection Procedure (रोजगार में चयन प्रक्रिया):
The candidate will be selected by the merit list on the basis of the marks obtained in the written examination. The Madhya Pradesh Professional Examination Board (MPPEB) will prepare the Final Merit List of the candidates based on their performance both in the Optical Mark Recognition Based Written Examination, Document Verification & Final Cut off List.
How to apply?(आवेदन कैसे करे):
Interested & Eligible Candidates can apply Online through the website http://www.vyapam.nic.in/ as per schedule mentioned above through the below link (इक्छुक उम्मीदवार अपना आवेदन नीचे दिए लिंक पर करे).
MP VYAPAM Samvida Shikshak Bharti Admit Card 2018
MP VYAPAM Samvida Shikshak Bharti Admit Card 2018. When they will upload the exam admit card at the website then the candidates may download the Admit Card for Samvida Shikshak grade First/Second/Third in 15 days before the examination. you can download by providing registration number and date of birth etc details and submit through the website of MP Vyapam.
MP VYAPAM Samvida Shikshak Result 2018
Those applicants who are waiting for the MP VYAPAM Samvida Shikshak Result 2018 they can check it on the MP Vyapam Government official web portal at http://www.vyapam.nic.in/.
Important Links
MP VYAPAM Samvida Shikshak Bharti Notification 2018: Click
MP VYAPAM Samvida Shikshak Bharti Apply Online
Official Website: Link
Note (ध्यान देंवें) : To know more about this post Please refer official advertisement for Education qualification, Age relaxation, Application Fees and other Information (पद से सम्बंधित अधिक जानकारी के लिए तथा शैक्षणिक योग्यता, आयु एवं आवेदन शुल्क से सम्बंधित अन्य जानकारी के लिए कृपया विभागीय विज्ञापन का अवलोकन करें)
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CG PHED Handpump Technician Vacancy 2017-18
AIIMS Raipur CG Vacancy for Various Group "C" & "B" Posts 2017
CG Vyapam Direct recruitment of staff nurse in Employee State Insurance Services
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Chhattisgarh Teacher Eligibility Test 2017 (CGTET17) छत्तीसगढ शिक्षक पात्रता परीक्षा -2017
Tags: Application Form, mp 41000 samvida jobs, mp samvida shikha form, mp samvida shikshak 2018, mp samvida shikshak bharti, MP Vyapam vacancy, samvida exam date 2018, samvida shikshak 2018, samvida shikshak recruitment 2018, samvida shikshak varg 1, samvida shikshak varg 2, samvida shikshak varg 3, samvida vacancy, Vacancies, vyapam.nic.in, www.vyapam.nic.in


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An Underground Adventure of Mammoth Mazes
Drop, squeeze and scurry through snug spaces in a world of underground challenges.
Weave your way through one area to another towards your destination with tip top communication – a great way for families to bond and work together.
Different difficulty levels mean there's something for the whole family to enjoy and get stuck in to (quite literally).
Think this is the perfect activity for your next day out? Plan your adventure today by calling us on 01708 224753 (9am-5pm) or visit our dedicated contact page.
Key info:
- Time – allow up to 90 minutes for this activity
- Ages – 5 1/2 years+
- Maximum weight – 18 stones (114kg)
- Don't bring the bling! – all jewellery, including piercings, must be removed for this activity
- Children under 16 – must be under direct parent/guardian supervision
- Children under 18 – must have a Medical & Risk declaration form signed by their legal parent/guardian before being allowed to participate. This will be emailed to you with your booking
- Enclosed Footwear – open toed shoes, "croc" type shoes or open back shoes are not permitted for this activity


text:
Search hotels
Top destinations
Useful Links
Ringhotel Chateau Berlin From EUR 80.1,-
Knesebeckstr. 38-49 10719, Berlin, Germany
Quick description
Extra Information
Hotel information
We offer 2 function rooms for conferences with a capacity for 60 people. Modern conference technology and the latest technical equipment will help make your conference a success.
Parking is available on-site.
Room information
The tastefully designed rooms, equipped with direct dial telephones, room safe, TV with pay channels, minibar and wireless internet, meet the demands of business and leisure travellers alike.
All rooms are fully air conditioned.
For your comfort, the rooms feature a private bathroom with bath, cosmetic mirror and hairdryer. Smoking and non-smoking rooms are both available on request, subject to availability.
Food & beverage
Have a good start into the day with an extensive and varied French breakfast, offering fresh and homemade croissants and baguettes.
You can also choose from a rich variety of alcoholic and non-alcoholic drinks at our lobby bar.
Hotel Policies
Cancellation Policy
Cancellation Policy: If cancelled or modified up to 2 days before date of arrival, no fee will be charged.
If cancelled or modified later, 80 percent of the first night will be charged.
In case of no-show, the first night will be charged.
Children and Extra Bed Policy: All children are welcome.
All children under 12 years stay free of charge when using existing bedding.
All children under 2 years stay free of charge for cots.
All older children or adults are charged EUR 30.00 per night and person for extra beds.
Maximum capacity of extra beds/babycots in a room is 1.
Deposit Policy: No deposit will be charged.
VAT and city/tourist taxes: VAT is included.
Service charge is included.
City/tourist tax is not applicable.
Internet: Wireless Internet Hotspot is available in the entire hotel and is free of charge.
Meal Plan: Buffet breakfast is included in the room rate.
Parking: Private parking is possible at a location nearby and costs EUR 14.00 per day.
Pets: Pets are allowed. Charges may be applicable.
The hotel reserves the right to pre-authorise credit cards prior to arrival.
Accepted credit cards
American Express, Visa, Euro/Mastercard
07:00 hours.
07:00 - 12:00 hours.
Ringhotel Chateau Berlin From EUR 80.1,-
Knesebeckstr. 38-49 10719, Berlin, Germany
More Photos
Click thumbnail to see larger photo.
Ringhotel Chateau Berlin From EUR 80.1,-
Knesebeckstr. 38-49 10719, Berlin, Germany
Making your reservation
You can guarantee your booking with American Express, Visa and Euro/Mastercard. Please note that the property you have selected may require a different method of payment upon arrival, but this will be detailed in both your on-line and email confirmations.
The hotel and not 2hotel.be makes all charges to your credit card.
Making your reservation is easy and safe:
Short terms and conditions
Your reservation is absolutely secure. All personal data is encrypted and will be processed in a secure way. 2hotel.be takes the privacy of your personal data very serious. Your personal information will only be used to process your booking. 2hotel.be will not charge you any reservation fees for making this booking, nor charge your credit card. You will simply pay for your stay at the hotel. Cancellation is free of charge; provided you adhere to the notification period stated in the hotel cancellation policy (see "Hotel Policies" under Overview ).


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This is Peter Saville's new design for Tate Modern's new "Switch House" pale ale.
Saville is a British graphic designer. We've mentioned him a couple times before. (See also: More Transparent Branding and Blue Monday: color coded branding)
Saville worked with Tate Design Studio on the packaging design, which is silver with brightly coloured geometric artwork.
Peter Saville designs packaging for Tate Modern pale ale
Dezeen, July 25, 2016
The museum beer packaging is an extension of Saville's color-coded brand identity for Tate Modern's "Switch House" gallery in London. The beer take its name from the building—a former power station and was brewed by Fourpure Brewing.
I hadn't realized that art museums were now selling beer as a consumable sort of brand collateral. Tate Modern, however, appears to having been doing this a while now.
Tate Britain and Tate Modern, London's famous art galleries, have introduced its own gin and limited edition beers…
The Tate's exclusive range of beer will be labelled with art work inspired by the latest exhibitions held at the London galleries.
The Tate launches gin and beer, Drinks International, 2013
FMCG as Art
For the Switch house beer can, the designers used Saville's abstracted diagram of the building on the front of the can, and then tucked the museum's brand logotype tastefully out of sight at the back of the can.
Photos via: Untappd
We've seen this kind of "designer pack" before: a familiar commercial container, incongruously devoid of any (obvious) branding.
There was a time when consumers didn't much like commercial packaging on their dinner tables. In recent years, of course, we've been conditioned to accept it more and more.
Yet, for those still wishing to control their intake of branding messages, a package with "art" as a label may seem preferable to one with a prominent brand logo. Naturally, an art museum is uniquely well-positioned to give its packaged products this aura of fine arts.
Museum gift shops have long been an outlet for housewares with artistic aspirations. But museum beer was new to me. Will logo-suppressed "fast-moving-consumer-goods" be the wave of the future for museums and non-profits?
More about "museum beer" after the fold…
Bottled vs. Canned
Earlier craft beers by Tate Modern have been bottled beers with printed labels.
The museum "collaborated" with Mad Hatter Brewing to make "Dazzle" Beer. Sir Peter Blake had designed his "Dazzled" Mersey Ferry and Museum Cafe for Tate Liverpool. The beer was another brand extension of Blake's project.
Blake's Dazzle design on the… ferry commemorated the centenary of World War One and was inspired by the work of ship designers who used the "dazzle" effect to try to avoid detection by the enemy.
The bright and twisty designs made it harder for hostile forces to track the range of allied ships.
BBC News, March, 2016
(In 1955, package designer Milner Gray wrote about "dazzle painting" as it relates to packaging design.)
Tate Modern has launched other bottled beers promoting exhibitions of Paul Klee and Piet Mondrian.
But even if Saville's Switch House ale is not the first "museum beer" ever, it might just be the first canned museum beer.
We will therefore confine ourselves to canned museum beer for what I am now declaring to be "Canned Museum Beer Week."


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Having a WordPress Membership site doesn't have to be hard.
Let WP Rebilly handle it for you - so you can focus on what you do best: your business. Request your invite now and do more today!


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On Wednesday this week, South Africa's finance minister Malusi Gigaba delivered the 2018 budget speech in parliament. The budget focuses on cost savings in government, makes money available for the beginning of the National Health Insurance scheme as well as free tertiary education, and seeks to lower the amount of government bloat and the cost of supporting state-owned enterprises. If you already felt yourself falling asleep just reading that, don't worry – the speech really was that boring. But there were two changes that Gigaba highlighted in his budget speech that affects gamers in the country – the VAT increase and changes to the luxury goods tax.
You can read up on the budget as a whole in this article on BusinessTech. The changes to the budget are wide-ranging, but we're really only interested in what effects the changes have on our primary hobby – gaming. All of these changes will come into effect on 1 April 2018.
VAT increases from 14% to 15%
In the first change to VAT in the country for more than 20 years, government is committing themselves to increasing the VAT rate to 15%. This tax affects everyone and almost everything sold in stores across the country. And it affects our games bought online through Steam, EA Origin, Uplay, the PlayStation Store and the Microsoft Store. Games will see a 1% hike in their prices overall. It's not a massive change considering how much our games cost these days (1% of R899.99 is only R8.99), but it's definitely going to move the price brackets of games up a bit. Lets say you buy six games a year at R899 each – that's an extra R54 you had to pay in.
This also hits software like Microsoft Windows 10. The average price for Windows 10 Home is R1900, and after 1 April it'll be R19 more expensive. If you're buying hardware, that Ryzen 7 1800X just got hiked up by R52 on average. It's not a huge amount, but this adds up thanks to how many people are spending their hard-earned money buying stuff.
Given that there's a bill going into effect on 1 October 2018 that applies VAT to every service rendered over the internet, tacking an extra 15% to the cost price of online services that previously didn't charge VAT may be enough to affect the profitability of online services, as well as the likelihood of consumers using them. This could affect things like software subscriptions (Xbox Live Gold comes to mind), or cryptocurrency exchanges like Luno.
Ad Valorem tax increases from 7% to 9%
A change that was unexpected, government is planning to add smartphones to the luxury goods/ad valorem tax code as well as increasing the tax price by 2% for luxury imported goods. The ad valorem tax covers everything from cars, to electronics, cosmetics, perfumes, and other goods considered luxury items. Electronics and electronic equipment basically applies to all computer parts, so that Ryzen 7 1800X just tacked on another 2% to the final total. Smartphones just got 9% more expensive as well, so that's going to affect prices of cellphone contracts as well as sales of phones through other retailers.
Ad valorem tax is applied to the value of the product as it enters the country, imported by an authorised distributor, and it increases the cost price of the product, not the final price. Still, consumers will bear the cost of that increase in the final price of the product. That Ryzen 7 1800X you've been eyeing will pick up another R103 to the price after the change takes place. Apple's new iPhone X, already priced at a hefty R18,999 for the silver 64GB model, sees a 10% increase overall, moving up to R20,899.
Fuel levy increases by 52 cents
For physical goods that need to be transported, the fuel levy increase is going to affect the costs for suppliers and retailers, which will inevitably see a hike on the shelf price as well. Diesel per litre currently costs around R12.60, so a 52c increase is roughly a 4% increase in the fuel price. This affects many parts in the supply chain from importer to retailer. You're going to see an increase in the price of the product you're buying on the shelf or online, because delivery costs have increased. You're also going to pay more for delivery from Raru, or Rebel Tech, or Wootware thanks to the increase. Whoop-de-doo.
The 4% increase won't result in a 4% increase on the shelf price, though. It's rarely a 1-to-1 gain because goods are transported in bulk, so the increase may be smaller than expected because of what goods are being transported, and by whom. But let's say that it'll increase the price of a Ryzen 7 1800X by 3%. Taking into account the VAT and ad valorem tax increase, we're looking at a 6% increase in the final price, or about R300. My recommended R5,000 build in the System Builder's Guide currently sits at R5,198. The parts in that list come from three different retailers, so there's three separate delivery charges in addition to the 6% increase of the parts themselves.
All told, we might be looking at a total increase of about R350 once all charges are accounted for. And that's just for the cheapest build. Thinking of spending R13,000? You might be facing a price increase of R780 after 1 April. Eish!
For those of you thinking of buying a new system, getting that game or DLC, or subscribing to Xbox Live Gold or PlayStation Plus, or Netflix, it might be worth your while to pick those up before the tax changes come into effect. You could save yourself a lot of money in the process.