text: NewsBest Multiple Myeloma Research, 2015Vij, Ravi MD, MBAOncology Times: January 10, 2016 - Volume 38 - Issue 1 - p 1,13-14 doi: 10.1097/01.COT.0000479752.54806.45 Free Metrics FigureRAVI VIJ, MD, MBA. RAVI VIJ, MD, MBA, is Professor of Medicine in the Section of Stem Cell Transplant and Leukemia, Division of Medical Oncology, at Washington University School of Medicine in St. Louis, Missouri.2015 was a very exciting year for us myelomatologists. The FDA approved four new agents for multiple myeloma (panobinostat, daratumumab, ixazomib, and elotuzumab). In 2016 we will have to begin the task of determining the most appropriate combinations and sequencing of agents. This is a review of some of the key manuscripts published this year of relevance to the practicing oncologist. Workup and Staging 2014 gave us revised criteria for the diagnosis of multiple myeloma; and in 2015 we now had several important manuscripts providing guidance on the diagnostic workup and prognostication for the disease. Dimopoulos et al (JCO 2015; 33:657-664) reported a consensus statement from the International Myeloma Working Group (IMWG) on the use of magnetic resonance imaging (MRI) in multiple myeloma. The authors concluded that MRI was the gold standard for imaging of the axial skeleton, for evaluation of painful lesions, and for distinguishing benign from malignant osteoporotic vertebral fractures. The authors recommended that in addition to visualization of the spinal cord or nerve compression and the presence of soft tissue masses that MRI be used for the workup of solitary bone plasmacytoma and that all patients with smoldering myeloma undergo full body MRI or spinal and pelvic MRI if whole body MRI is not available. If these patients have more than one focal lesion of greater than 5 mm in diameter, they should be considered to have symptomatic disease for consideration of therapy. In cases of equivocal or small lesions, a second MRI should be performed after three to six months and if there is progression on MRI, the patient should be treated as having symptomatic myeloma. For patients with an established diagnosis of multiple myeloma, an MRI at diagnosis and after treatment, especially autologous stem cell transplantation, was thought to provide prognostic information, but to date does not change treatment selection. Palumbo et al (JCO 2015: 33:2863-2869) published a revised international staging system for multiple myeloma on behalf of IMWG. Clinical and laboratory data from 4,445 patients with newly diagnosed myeloma enrolled into 11 international trials were pulled together, and this revised international staging system combined the exiting international staging system with chromosomal abnormalities detected by interphase fluorescence in situ hybridization after CD138 plasma cell purification and serum lactate dehydrogenase (LDH) to evaluate prognosis: Revised ISS I: ISS stage I, no high-risk cytogenetic abnormalities (deletion 17p, t(4;14) and/or t(14;16)) and normal LDH with a five-year overall survival (OS) of 82 percent and five-year progression-free survival (PFS) of 55 percent; Revised ISS 2: Not R-ISS I or III with five-year OS of 62 percent and five-year PFS of 36 percent; Revised ISS stage III: Including ISS stage III and high-risk cytogenetics or high LDH level with five-year OS of 40 percent and five-year PFS of 24 percent. Recently, next-generation sequencing (NGS) technologies have defined for us the mutational spectrum of patients with multiple myeloma and the clonal heterogeneity that characterizes this disease like several other hematological neoplasms. However, past publications did not establish the clinical relevance of these mutations. Walker et al (JCO 2015; 33:3911-3920) performed whole exome sequencing for 463 patients with newly diagnosed multiple myeloma who are enrolled onto the National Cancer Research Institute Myeloma-XI Trial for whom complete molecular cytogenetic and clinical outcome data were available. The researchers identified 15 significantly mutated genes. The mutational spectrum was dominated by mutations in RAS (43%) and nuclear factor kappa B (17%) pathways. Though prognostically neutral, these could be potentially targeted therapeutically. Mutations in CCND1 and DNA repair pathway alterations (TP53, ATM, ATR, and ZNFHX4 mutations) were associated with a negative impact on survival. In contrast, IRF4 and EGR1 mutations were associated with favorable overall survival. The authors combined these known mutation risk factors with recurrent molecular adverse features and the international staging system to generate a prognostic score that could identify high-risk populations. Though exome sequencing is not yet a clinical standard, one could imagine a not too distant future where this may become mainstream, and such a prognostic system could then become clinically useful. Therapeutics 2015 saw the promise of monoclonal antibody therapy in multiple myeloma become a reality, and two seminal papers in the New England Journal of Medicine attested to the dawn of a new era. Lonial et al (NEJM 2015; 373:621-631) reported on a Phase III study with patients randomly assigned to receive either elotuzumab, an immunostimulatory monoclonal antibody targeting signaling lymphocytic activation molecule F7 (SLAM F7), plus lenalidomide and dexamethasone or lenalidomide and dexamethasone alone. A total of 321 patients were assigned to the elotuzumab group and 325 to the control group. After a median follow-up of 24.5 months, the PFS at one year in the elotuzumab group was 68 percent compared with 57 percent in the control group, with two-year PFS rates of 41 and 27 percent, respectively. The median PFS in the elotuzumab group was 19.4 months versus 14.9 months in the control group (hazard ratio 0.70; p< 0.001). The overall response rate in the elotuzumab group was 79 percent versus 66 percent in the control group (p< 0.001). Lokhorst et al (NEJM 2015; 373: 1207-1219) reported on a Phase I/II study of single-agent daratumumab, a CD38 targeting human IgG1 kappa monoclonal antibody in patients with relapsed and/or refractory multiple myeloma. Patients had received a median of four prior treatments. The overall response rate was 36 percent in the cohort that received the Phase II dose of 16 mg/kg. The median PFS was 5.6 months, and 65 percent of responders did not have progression at 12 months. Infusion-related reactions were mild, and the most common adverse events of grade 3 or 4 severity were pneumonia and thrombocytopenia. 2015 also saw the publication of the ASPIRE trial for patients with relapsed multiple myeloma comparing the regimen of carfilzomib with lenalidomide and dexamethasone with lenalidomide and dexamethasone alone (Stewart et al: NEJM 2015; 142-152). PFS was significantly improved in the carfilzomib arm (median 26.3 vs. 17.6 months; p=0.0001). The overall rates of response were 87.1 and 66.7 percent, respectively (p< 0.001). A total of 31.8 percent and 9.3 percent of patients in the respective groups had a complete response or better. Grade 3 or higher adverse events and rates of discontinuation owing to adverse events were comparable in the two arms. Dimopoulos et al reported results of the ENDEAVOR trial (Lancet Oncology, published online: 05 Dec 2015; doi.org/10.1016/S1470-2045(15)00464-7). In this randomized, Phase III, open-label, multicenter study, patients with relapsed or refractory multiple myeloma who had one to three previous treatments were randomly assigned (1:1) to receive carfilzomib with dexamethasone or bortezomib with dexamethasone. Patients received treatment until progression with carfilzomib (20 mg/m2 on days 1 and 2 of cycle 1; 56 mg/m2 thereafter; 30 min intravenous infusion) and dexamethasone (20 mg oral or intravenous infusion) or bortezomib (1.3 mg/m2; intravenous bolus or subcutaneous injection) and dexamethasone (20 mg oral or intravenous infusion). 929 patients were randomly assigned (464 to the carfilzomib group; 465 to the bortezomib group). Median progression-free survival was 18.7 months (95% CI 15.6–not estimable) in the carfilzomib group versus 9.4 months (range of 8.4-10.4 months) in the bortezomib group at a preplanned interim analysis (p<0.0001). On-study death due to adverse events occurred in 18 of 464 patients (4%) in the carfilzomib group and 16 of 465 patients (3%) in the bortezomib group. Serious adverse events were reported in 224 of 463 patients (48%) in the carfilzomib group and 162 of 456 patients (36%) in the bortezomib group. The most frequent grade 3 or higher adverse events were anemia (67 [14%] of 463 patients in the carfilzomib group vs. 45 [10%] of 456 patients in the bortezomib group), hypertension (41 [9%] vs. 12 [3%]), thrombocytopenia (39 [8%] vs. 43 [9%]), and pneumonia (32 [7%] vs. 36 [8%]). The combination of bortezomib, lenalidomide, and dexamethasone has become a popular regimen for the treatment of patients with multiple myeloma. With the approval of the next-generation proteasome inhibitor carfilzomib and the immunomodulatory drug pomalidomide, it makes rational sense to now combine these drugs as well. Shah et al (Blood 2015; 126: 2284-2290) reported the results of a Phase I/II trial of carfilzomib with pomalidomide and dexamethasone for relapsed or refractory multiple myeloma. The maximally tolerated dose of the regimen was carfilzomib 20/27 mg/m2 on days 1, 2, 8, 9, 15, and 16, pomalidomide 4 mg daily on days 1 through 21, and dexamethasone 40 mg oral or IV on days 1, 8, 15, and 22 of a 28-day cycle. The combination was well tolerated and highly active in patients with relapse/refractory multiple myeloma. Autologous Stem Cell Transplantation (ASCT) In the era of proteasome inhibitors and immunomodulatory drugs, the integration of ASCT in the therapeutic armamentarium continues to be validated. Gay et al (Lancet Oncology 2015; 16:1617-1629) performed an open-label randomized multicenter Phase III study enrolling transplant-eligible patients with newly diagnosed multiple myeloma aged 65 years or younger. Patients received a common induction with four cycles of lenalidomide and dexamethasone followed by chemotherapy with cyclophosphamide and G-CSF for stem cell mobilization and collection. Using a 22 factorial design, patients were randomized to either consolidation with chemotherapy (six cycles of cyclophosphamide) or two courses of high-dose melphalan (200 mg/m2) and ASCT. There was a secondary randomization thereafter to maintenance with either lenalidomide alone (10 mg days 1 through 21) or lenalidomide with prednisone (50 mg every other day). For the 389 patients enrolled, PFS during consolidation was significantly shorter with chemotherapy plus lenalidomide compared with high-dose melphalan and ASCT (median 28.6 months vs. 43.3 months; P < 0.0001). PFS did not differ between the two maintenance arms (median 37.5 months with lenalidomide and prednisone and 28.6 months with lenalidomide alone; P=0.034). A key question regarding stem cell transplantation for patients with multiple myeloma is whether patients should move to transplantation after a finite period of therapy or continue with induction chemotherapy until maximum disease response before embarking on autologous stem cell transplantation. This controversy was sought to be addressed in a CIBMTR analysis (Vij et al: Biology of Blood and Marrow Transplantation 2015; 21:335-341). In this analysis, 324 patients who received additional salvage chemotherapy after failing to achieve a partial response to first-line induction chemotherapy were compared with 215 patients who had no additional salvage chemotherapy immediately before autologous stem cell transplantation. Though additional pre-transplant chemotherapy resulted in deeper responses in 68 percent of patients, multi-variant analysis showed no impact of pre-transplant salvage therapy on treatment-related mortality risk for relapse, progression-free survival, or overall survival. The authors concluded that for patients achieving a less than partial response to initial induction therapy including those with novel agent combinations, additional pre-autologous transplant salvage chemotherapy was not associated with a survival benefit. This indirectly seems to suggest that additional therapy to deepen responses may not be of benefit prior to autologous stem cell transplantation. Duration of Therapy One of the most vexing questions in the therapeutics for patients with multiple myeloma has been whether continuous therapy has any advantage versus fixed duration therapy in patients with newly diagnosed multiple myeloma. Continuous therapy has been shown to prolong PFS1 (time from random assignment until first progression or death), but chemotherapy-resistant disease and relapse could potentially negatively impact overall survival. Palumbo et al (JCO 2015; 33:3459-3466) explored whether PFS2 (time from random assignment until second progression or death) presented an additional tool to estimate outcome and evaluate the benefit of novel agent-based continuous therapy versus fixed-duration therapy in patients with newly diagnosed myeloma. The authors studied the outcome of 604 patients in a pooled analysis of three randomized Phase III studies that randomly assigned patients to novel agent-based continuous therapy versus fixed-duration therapy. After a median follow-up of 52 months, continuous therapy significantly improved PFS1 (median 32 vs. 16 months; p< 0.001), PFS2 (median 55 vs. 40 months; p< 0.001), and OS (median four-year OS of 69% vs. 60%; p= 0.003). The improvement in PFS2 suggested that the benefit reported during first remission was not negated by a shorter second remission. However, certainly longer durations of therapy do add to the cost of therapy, which was a subject of much discussion both in the academic and lay press in 2015. In this regard, it is heartening to note that investigators are attempting to study the financial toxicity of therapy in patients with multiple myeloma. Huntington et al (Lancet Haematology 2015; 2: e408-e416) reported on a cross-sectional survey of individuals receiving treatment for multiple myeloma at a tertiary academic medical center in the United States. Fifty-nine percent of patients reported that treatment costs were higher than expected; 71 percent said they had at least a minor financial burden; 36 percent needed financial assistance; 46 percent had to dip into savings to pay for myeloma treatment; and 21 percent said they had to borrow money to pay for medication. The manuscripts discussed here offer only a snapshot of the substantial body of literature that accumulated during 2015. However, this is sufficient proof that myelomatologists have been making steady progress against a devastating disease. I have no doubt that they will reap a bumper crop in 2016 as well. Links to Studies Access the hyperlinks (shown in grey) for all the abstracts noted by reading this article on our iPad app, or by reading the pdf of the article on oncology-times.com.Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.View full article text


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Decades before Forrest Ackerman, the creator of the Famous Monsters of Filmland magazine, coined the genre title "Science Fiction" in 1954, illustrators were creating images of fantastic worlds published within the pages of books and magazines.
From 1863 to 1905, French author Jules Verne employed over 4,000 woodcuts and drawings to illustrate his series of novels, Voyages Extraordinaires. The anthology included such classic titles as Journey to the Center of the Earth (1864), From the Earth to the Moon (1865), Twenty Thousand Leagues Under the Sea (1869), and Around the World in Eighty Days (1873).
Illustrator Warwick Goble provided the images for H.G. Wells' novel The War of the Worlds in its first edition in 1898. However, the terrifying images more commonly associated with the book came from the hand of Brazilian artist Henrique Alvim Corrêa, who illustrated the book's 1906 edition.
Throughout the first half of the 20th century, Science-Fiction (or Fantasy, as it was called then) illustrations were primarily printed in pulp magazines like Amazing Stories, Wonder Stories, Weird Tales, Captain Future, and Fantastic Adventures. The pulp art appeared as cover paintings and interior story art alongside fiction written by many well-regarded authors of the genre, such as Edgar Rice Burroughs, Ray Bradbury, H.P. Lovecraft, H.G. Wells, and Arthur C. Clarke. It was in the opening pages of Amazing Stories, No. 1, April 1926, in which editor Hugo Gernsback first referred to the genre as "Scientifiction."
Once the pulp industry began its steady decline in the 1940s, science fiction illustration became prevalent in the pages of superhero comic books and magazines like Mad, Famous Monsters of Filmland, and Heavy Metal, and the roleplaying game Dungeons & Dragons. In the 1970s, artists like Frank Frazetta, Vincent Di Fate, Boris Vallejo, Moebius, Ralph McQuarrie, and William Stout took up the mantle of the artists before them. Their work was occasionally adapted to the big screen in films like Star Wars (1977), Heavy Metal (1981), and Conan the Barbarian (1982). Illustration is still widely used in the concept art for science-fiction films of today.

subset: commoncrawl


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Alcohol in Fitness
The metabolism of alcohol on the body effects physiological functions of organs and disrupts processes by which the human body derives vitality. This article treads lightly over the possible effects alcohol can have on the body that are harmful to the development sought when trying to accomplish goals in fitness. As I am not a…Read More
Skip the Raw Eggs- Protein Pancakes Have Arrived
Sorry Rocky, but cooked breakfast sounds a little more appetizing than chugging raw salmonella. And, these protein pancakes have nearly the same amount of protein as an egg does; only, they're a little more delicious. I am not a morning person, but these pancakes make me roll out of bed and waddle my way to…Read More
Holiday Love Handles
It's tough to say 'no' to holiday cheer when it comes in endless cookies and endless calories… but how can we refrain from retaining all that weight? Personally, I've found it to be fairly simple. It's a matter of making a few key decisions, and being a bit smarter about what you choose to consume.…Read More
Beginners Guide to Middle-aged Fitness
Prologue This is an introductory workout, diet, and weight loss program; meaning this is what we need to do to get you started! The routine should suffice for about a month, at which point you should re-evaluate your current level of health, goals, and amount of time that you can spend exercising. This workout is…Read More


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James Purnell has been named as the new secretary of state for work and pensions following Peter Hain's resignation on 24 January.
Hain stepped down from the Cabinet after the Electoral Commission requested a police investigation into the way he funded his deputy leadership campaign.
Purnell, Labour MP for Stalybridge and Hyde in Greater Manchester, has previously served the Cabinet as culture secretary and has also served as pensions minister in the Department for Work and Pensions.
The 37-year-old has made the headlines for announcing Gordon Brown's U-turn on super casinos and for reprimanding the TV channels during vote rigging and "faked footage" scandals.
But he was left red-faced last year when the NHS superimposed his image onto an official photograph after he was unable to attend the photo shoot.
During his time as pensions minister he worked on the development of the national pensions savings scheme.
Purnell says: "I am delighted to be returning to the Department for Work and Pensions, to deepen the reform of the welfare and pension systems and continue to tackle child poverty.
"My aspirations are to ensure everyone has the chance to be self-reliant in old age, and to make work the right - and the responsibility - of everyone who is capable of it."
James Purnell has been named as the new secretary of state for work and pensions following Peter Hain's resignation on 24 January.


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Avène TriAcnèal 30ml
Avène TriAcneal Cream is an innovative product that is used to help eliminate severe imperfections, including blemishes and reduce the appearance of scarring.
In stock
Avène TriAcneal Cream is an innovative product that is used to help eliminate severe imperfections, including blemishes and reduce the appearance of scarring.
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Why has my order not yet been dispatched?
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text: Discover We are supported by a wide range of research facilities across our four university partner institutions. Our academic staff are able to utilise these capabilities as needed when working on a project. 正规福利彩票幸运飞艇5分 钟开奖In our film library you will find a number of short films about our interdisciplinary research and the industrial impact we are having on the energy sector. Research facilities 正规福利彩票幸运飞艇5分 钟开奖Discover the facilities at our disposal. READ MORE >> Film library Watch our latest video content. WATCH NOW >>


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Our weekends are normally saturated with lots of sleep. So it is quite common for us to wake up at almost noon, practically in time for lunch. The problem with that is we would miss out on having a proper meal at lunch time and we would end up eating junk instead.
Thankfully, there are still hawker restaurants that serve lunch until 3:00pm, and one of these sold curry laksa which I have grown to love. My husband, on the other hand, can be quite fussy with what he wants to eat, so today, we shall leave him out of the equation.
This particular curry laksa (as shown in the picture above) did not have too much spicy sensation in its soup, nor did it taste too sour either. My guess was maybe customers may have complained about the amount of chilli she added in it, or that they weren't used to the soup being too sour to consume.
Whatever the reason, it had just the right amount of flavour to it. Her bowl of curry laksa had a lot of contents as well, such as chicken thighs, tau fu pok (deep fried tofu puffs), fu chuk (deep fried tofu skin), taugeh (bean sprouts), fried fish balls, and occasionally, some squid and cockles, so I don't have so much of a bone to pick with it.
However, if you spoke to a true consumer of all things laksa, he or she would probably abandon the bowl and walk away.
Because laksa, in general, is meant to be spicy and/or sour. Let me spin you a tale about the deliciousness of laksa.
Despite making its appearances in Indonesia and Singapore, laksa is Malaysian in origin, and Malaysia remains the best place to try it in its many forms. Why some people call it curry laksa or curry mee has always baffled me. Until I learnt that the term laksa is the Persian word laksha for noodles.
There are two main types of laksa, with a number of variations for both. The first type is commonly known as curry laksa or curry mee (the word mee being a Chinese name for noodles). This laksa is easily identified due to its use of coconut milk, and can be found in Singapore as well as the southern tip of Malaysia. The base of this dish is made from shallots, garlic, lemongrass, chilli paste, coriander seeds, and belacan (Malaysian shrimp paste), all grounded into a curry paste. This paste might vary from stall to stall, with a final touch of chilli oil added into the broth just before serving. Other common ingredients you can find nesting on a bed of noodles (your choice of vermicelli or yellow noodles) are bean sprouts, shredded chicken, seafood, halved pieces of deep fried tofu puffs, and half a hard boiled egg. Again, what you find in your bowl may differ from stall to stall.
Sometimes, you will see people adding sambal, a squeeze of lime juice, or a sprinkle of dried chillies for the extra oomph. It usually depends on what your preferences are, and well, you are what you eat!
The other type of laksa is called asam laksa or just Penang laksa, which is essentially where the dish calls home. Asam in Malaysia means sour, as the tamarind (the fleshy fruit of the tamarind tree) is a major component of the flavour in this sour and spicy dish.
The base of the broth in this dish comes from wholly fish stock, commonly made from mackerel and sardines, and often, you will find pieces of these fish in your bowl of noodles. Asam laksa is usually eaten with a small bowl of black shrimp paste which you will mix in according to your own taste. Other ingredients include julienned cucumbers, mint leaves, red onion, cili padi (bird's eye chilli), strips of pineapple, the laksa leaf, and the perfumed, unopened flower of the torch ginger (otherwise known as bunga kantan).
One can find laksa stalls in many restaurants and shopping malls in Malaysia. Some vendors only sell one type of laksa, but it is also common to find vendors selling both types of laksa. All these vendors need are a huge pot of stock required for each type of laksa, and all the necessary condiments, and they're good to go. They only close up for the day once they have exhausted their inventory. Then, they go home and come back again for business the next day.
What makes laksa so wonderful in Malaysia is that you have the opportunity of trying out the different variations of the noodles in different cities and towns that you visit. Try the Penang laksa as many have claimed that it being the home of the dish, it is therefore the best place to have it. Otherwise, you can go to Sarawak and have their version of laksa or remain in Kuala Lumpur to try all the different types of laksa under one roof.
Why don't you put your tastebuds to the test and tell me which ones you like best? Will it be the sweet-sour and spicy mix of the asam laksa or the creamy coconut milky mix of the curry laksa?
Source: Asian Correspondent.


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Agave ovatifolia
Pronunciation: Uh-gah-vay oh-vay-tih-foh-lee-a
Family: Agavaceae
Common Name: Whale's tongue agave
Plant Type:
- perennial
- succulent and cactus
Height to: 4'
Width to: 5'
USDA Hardiness Zones:
- 10 to 0ºF ZONE 7
- 20 to 10ºF ZONE 8
- 30 to 20ºF ZONE 9
- 40 to 30ºF ZONE 10
Notes for Identification: Origin: from the mountainous regions of northeastern mexicohardiness zones sunset 12-24 usda 7-10 landscape use: strong gray accent, focal point for desert gardens; oasis and xeric landscape design themes. Great for use around desert and oasis ramadas and patios, even in large containers. Often effectively used in mass or groups spaced at 6' to 8' on center. Form & character: broadly spreading, wide, exposed, stiff and pointed, imposing. Growth habit: solitary (non-offsetting) with a hemispherical rosette reaching anywhere from 2' to 4' tall by 3' to 5' feet across; eventual size much influenced by available water. Foliage/texture: broad leaves are presented in a regular rosette pattern, somewhat reflexed, strap-shaped, succulent, grayish to 2' long. Leaves are coarsely serrate and taper to a distinct sharp, grayish black spiny tip, coarse texture flowers & fruits: whale's tongue agave will produce a paniculate inflorescence that is about 10' to 14' tall and consists of several side branches (arborescent), each branch densely clustered with large, greenish yellow flowers, can produce bulbils in urban conditions. Seasonal color: none except when flowering. Temperature: very cold hardy to 5of, heat tolerant also. Light: filtered shade of a small desert tree is best. Leaves will yellow a bit when grown under full phoenix sun conditions. Soil: well-drained best watering: apply only occasional water once established. It readily responds to water by increasing growth and eventual size. Pruning: none propagation: seed disease and pests: root rot if soil is wet additional comments: this is a striking and imposing "smaller" agave. The gray color accent of the foliage is striking with juxapositioned to nearby landscape greenery.
USDA Heat Zones (days above 86ºF):
- 60 to 90 days ZONE 7
- 90 to 120 days ZONE 8
- 120 to 150 days ZONE 9
- 150 to 180 days ZONE 10
- 180 to 210 days ZONE 11
Submitted by: Distantkin
Seed photo: 0
Located in: Succulents


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Kendall Wilkinson and Assistant Coach Noelle Winkles cheer at first base. Mississippi University for Women's softball team won its first game of the USCAA Small College World Series on Monday. Photo by: Owls Communication/Courtesy photo
May 14, 2019 9:56:09 AM
DUBOIS, Penn. - Mississippi University for Women's softball team remains in the winner's bracket after defeating Carlow University 4-1 in the first round of the USCAA Small College World Series.
The No. 3 seed Owls (23-9) sent out their ace pitcher Madison Scoggin to take on the hard-throwing Carlow (18-21) pitcher Abby Stroud. What opened as a battle between defenses saw the Celtics land two hits and strand three runners in the first two innings.
The W broke the stalemate in the bottom of the second with a two-out rally. With Emily Littlejohn making it on base with a single, Carolyn "Kendall" Wilkinson reaching on an error, and Anna Lloyd scoring a base on balls, Kandler Flora stepped to the plate with bases loaded and singled to left field to bring in Littlejohn. Heidi Matthews followed Flora with a single of her own to bring in two runners and give the Owls a 3-0 advantage.
The Celtics scored their first run of the game with a bases-loaded no out fielder's choice to cut The W's lead to 3-1. To close out the frame, Matthews, at second base, and Brianna Duquette, at first base, executed a perfect double play for the remaining outs.
The lead for the Owls was expanded in the bottom of the sixth. After a single, a stolen base, and a wild pitch, Anna Lloyd was in prime scoring position. She scored the Owls last run of the game on a ground out with Megan James receiving credit for the RBI.
At the plate, Matthews, the senior second baseman, went 2-for-4 for two RBIs and Lloyd led the team in scoring on a 1-for-2 appearance for two runs.
On the mound, Scoggin threw her 13th complete game of the season. The senior from Bay Springs delivered three strikeouts with two walks for one earned run and eight hits against.
The Owls will return to action at 1 p.m. CT today when they take on Penn State University-Hazelton in the second round of the tournament.
Wright State-Lake 5, MUW 2: The No. 5 seed Owls baseball team opened the 2019 USCAA Small College World Series against the No. 4 Wright State University-Lake Campus on Monday afternoon at Showers Field.
After carrying the lead into the fifth inning, The W saw the Lakers bring in three runs on a single and a double to start a rally and close the game ahead of the Owls 5-2.
Returning from an injury, Owls ace pitcher Drew Williams took the mound against Wright State's Ryan Barker. Williams pitched a scoreless four innings, while Barker saw an unearned run in the first to start the competition.
In the top of the first, Heath Ford made it to base on a throwing error and advanced to second and Damain Benefield reached first on a walk. Johndavid Birdsong started the scoring effort with a single to left field to bring Ford home giving The W a 1-0 lead.
Both teams blanked in the second, third, and fourth inning but the Lakers scored three runs in the bottom of the fifth to take their first lead.
Benefield, the Owls power hitter, hit a home run over the left center fence to give the Owls an additional run and bring the score to 3-2.
Wright State did not let it go unanswered, scoring two runs on three hits to close the game 5-2.
Williams, Owls starter, pitched 4-1/3 innings for seven strikeouts, five walks, three earned runs, and four hits against.
Luke Hobson entered the game in the fifth to pitch 1-2/3 innings with two strikeouts, one walk, two earned runs, and four hits against.
With a single and a double, Birdsong led The W at the plate with a 2-for-3 appearance and one RBI, while Ford and Benefield scored one run each.
The Owls will be back in action today when they fight to stay in the tournament at 10 a.m. CST. They will face Penn State-Mont Alto.
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Class Dance Opinion
October 18, 2018
The class dance on September 21 was a big hit, although some did not agree with the results. The freshman came in fourth, sophomores in third, juniors in second, and as always, seniors in first place.
The freshmen were saddled with the theme Nashville, Tennessee, which already set them apart from the pop vibes of other themes. They didn't have many stunts, though. The freshmen are destined to get fourth every year, as part of the natural order of things. The dance was pretty good if you're a fan of country, but a lot of people aren't.
The sophomores' theme was Miami, Florida. The dance begun with a cardboard cutout of an airplane, which was a flashback to last year's PBS Kids dance . The music for this dance was sprinkled with Pitbull and just the right amount of songs about the beach and had a good balance of stunts and actual dancing. At some times, the dancing got a bit off beat, but I think the sophomore dance as a whole deserved second.
The juniors stole the show with their New York City theme. Packed with skyscraping stunts and references to several Broadway musicals, the junior dance was a showstopper. They performed stunt after stunt and all were nicely pulled off. Class of 2020 is notorious for winning the class dance, but came in second this year. This was a shock to some people, because they definitely deserved first this year.
And finally, the seniors. All in all, their dance was pretty good but not very impressive, starting out with the 90210 to 2019 stunt. The seniors didn't make a mess this year, which was unusual. Then came the sad part of the dance, the part where the seniors tug on your heartstrings by reminding you that they're graduating. According to a poll I did on Instagram where I asked participants to message me with their ideas of how the results should have gone, 32 of the 56 people that replied said the dance should have gone juniors, sophomores, seniors, freshmen.
We may all have different opinions, but I believe the dance should have gone juniors, sophomores, seniors, freshmen, all because of the quality of the dances. Not just because I'm a sophomore.
Ava Ryan is a sophomore member of colorguard in the DHS band, DECA, and a first-year member for the Pitchfork. She enjoys science and reading. In fact,...


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A beautiful figurine showing a mum with her son - A wonderful gift of portraying the bond between the two, ideal for Mothers day.
Beautifully sculpted and charged with emotion this range captures emotional moments and special occasions through poignant poses that powerfully express unspoken words straight from the heart.This charming Figurine is Exclusive to Crusader Gifts
Designed by Neil Welch, the More Than Words collection uses natural texture and subtle colour to create elegant sculptures with powerfully emotional themes; celebrating the special relationships that touch our lives.
Each sculpture comes with branded name cards, information on the rest of the collection and is beautifully packaged in a printed box. More Than Words is highly commended in the Gift Of The Year awards.
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Out of four Navratris, there are two Gupt Navratri Magh and Ashadh. These Navratris are not well known by people therefore called Gupt Navratri. During the Gupta Navratri, devotees worship the Maa Kali, Tara Devi, Tripura Sundari, Bhubaneswarwari, Mata Chinnamasta, Tripura Bhairavi, Maa Dhrumavati, Mata Baglakami, Matangi and Kamala Devi.
While the other Chaitra and Shardiya Navratri are famous and celebrated with joy. Some unique rituals like vashikarans, uchatans, stambhan, videshan and maran are performed in Gupt Navratri.
Magh Navratri is more famous in northern India, and Ashad Navratri popularly celebrated in Southern India.


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Send upcoming events to:
Friday 30
Eagles Auxiliary bingo: 1 p.m., Eagles Club, 146 N. Seventh.
Jolly Mixers bingo: 6:30 p.m. mini bingo, regular bingo 7:30, Muse Ballroom, 1700 Beverly.
Friday Night Live—The Hooten Hallers & Normal Reaction: 7 p.m., The Voo, 249 N. Santa Fe.
"Elf, the Musical": 7:30 p.m., Salina Community Theatre, 303 E. Iron. Tickets: $20-$35.
ABILENE—"Not Another Christmas Letter!" The Musical: 7:30 p.m., Great Plains Theatre, 215 N. Campbell.
Tickets: $20 students, $35 adults.
LINDSBORG—Fika Swedish Friendship Group and Coffee: 10 a.m., Bethany Lutheran Church, 320 N. Main.
LINDSBORG—American Legion Post 140 bingo: Doors open 5:30 p.m., games at 7, 524 E. State.
Saturday 1
Libertarian Party of Saline County meeting: 10 a.m., Mokas Bistro & Espresso, 2424 S. Ninth. All interested persons welcome.
Santa arrives at the VFW: 10 a.m.-noon, 1108 W. Crawford. Children's activities. Parents welcome to take pictures of their children with Santa. Free and open to the public.
Holiday Open House at Smoky Hill Museum: 1-3 p.m., 211 W. Iron. Music, refreshments, make and take crafts, door prizes and Pioneer Prairie Santa.
"Elf, the Musical": 7:30 p.m., Salina Community Theatre, 303 E. Iron. Tickets: $20-$35.
Karaoke with Miss Diny: 8 p.m., Salina Innovation Foundation, 336 S. Santa Fe.
The Country Unplugged Tour: 8 p.m., Stiefel Theatre, 151 S. Santa Fe. Tickets: $39-$64.
ABILENE—Breakfast with Santa: 9 a.m., Abilene Civic Center. Tickets: must be purchased by Nov. 30 at Abilene Community Center.
ABILENE—Holiday Craft and Vendor Show: hosted by Debbie Davis. 10 a.m. to 3 p.m., Sterl Hall, 619 N. Rogers.
ABILENE—Night of Christmas Magic: 3-8 p.m., 418 N.W. Third. Candy Cane Lane, ornament decorating, holiday movies, downtown carriage rides, holiday tree lighting and stories and photos with Santa.
ABILENE—Homes for the Holidays: 4-8 p.m. Dec. 1, Abilene Convention & Visitors Bureau, 201 N.W. Second. $10. For information: (785) 263-2231 or 1-800-569-5915.
ABILENE—"Not Another Christmas Letter! The Musical": 7:30 p.m., Great Plains Theatre, 215 N. Campbell. Rated G. Tickets: $20 students, $35 adults.
CAWKER CITY—Christmas Tree Lighting Ceremony: 6 p.m., Main Street/Highway 24. Visit by Santa Claus with hot drinks and treats for all. Sing Christmas carols and enjoy the holiday season.
DENMARK—Festival of the Nativities: 10 a.m. to 5:30 p.m., Denmark Hall, 7 miles west of Lincoln on KS Hwy. 18, then 3 miles north on 120th. 250 nativities displayed. By donation.
EMPORIA—East Central Kansas Model T Ford Club (ECKTs) lunch: 1 p.m., Corral Room, Pizza Ranch Buffet, 3000 W. 18th. Everyone welcome; reservations not required. Cost is cost of meal.
LINDSBORG—Senior Center Holiday Brunch: 9:30 a.m., 116 S. Main. Freewill donation.
LINDSBORG—Artist's Studio Open House: 10 a.m.-5 p.m., 212 S. Main. Working studios of 29 local artists at 20 different locations, museums and galleries. Brochure at Red Barn Studio with map and bio of artists.
LINDSBORG—Snowflake Parade: 11 a.m., Main Street from Saline to Grant. No entry fees or forms, if you'd like to be in the parade, simply show up at Bethany Lutheran Church parking lot by 10:30 a.m.
McPHERSON—Mini Main Street: 10 a.m.-1 p.m. Dec. 1, American Legion, 401 N. Main. Features products under $10, provided by local merchants. Volunteer wrappers wrap each gift.
McPHERSON—Historic Holiday Homes Tour: 12:30 p.m., McPherson Opera House, 219 S. Main. Proceeds benefit the opera house and McPherson County Food Bank. Tickets: $20.
McPHERSON—Holiday Open House and Raffle: 1-4 p.m. Dec. 1, McPherson Museum & Arts Foundation, 1111 E. Kansas. (620) 241-8465.
VESPER—Family Friendly Bingo: Doors open 5:30 p.m., bingo at 7, Vesper Community Center, 1247 N. 120th, Lincoln.


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CHICAGO — Sears, the once-dominant retail chain that changed how Americans shopped and lived, has filed for bankruptcy.
The 132-year-old company has been struggling for several years and is drowning in debt. The final straw was a $134 million debt payment due Monday that it could not afford.
Sears' parent company, which owns Sears and Kmart, is among dozens of prominent retailers to declare bankruptcy in the era of Amazon.
The filing in federal bankruptcy court in New York came just after midnight early hours of Monday. The company issued a statement saying it intends to stay in business, keeping stores which are profitable open, along with the Sears and Kmart online shopping sites. But it said it looking for a buyer for a large number of its remaining stores and that it will close at least an additional 142 stores near the end of this year, in additional to the 46 store closing already planned for next month.
Sears has been caught under the weight of its massive debt load and dwindling cash reserves. Over the decade, Sears sold many of its most valuable real estate and other assets to raise the cash it needs to survive.
It ditched Lands End in 2014. Three years later Sears dumped the Craftsman brand, which it had sold exclusively. Sears has been looking for a buyer for its Kenmore brand of appliances for years. The only buyer it could find was Eddie Lampert, its chairman and majority shareholder. He offered $400 million for Kenmore, but the Sears board never accepted the offer.
By September, Sears' market value had fallen below $100 million, less than quarter of the value of Kenmore itself.
Sears has been struggling to survive for years. It warned investors last year there was"substantial doubt" it would be able to stay in business. It has lost $11.7 billion since 2010, its last profitable year. Sales have plunged 60% since then. The company shuttered more than 2,600 stores over the past 13 years.
With the handwriting on the wall that a bankruptcy was imminent, suppliers demanded Sears pay cash up front for the items in its stores, putting it an even greater competitive disadvantage with other retailers.
Whirlpool, which had started in business more than a century ago selling its appliances at Sears, pulled its various brands out of Sears and Kmart stores in 2017. Once the dominant appliance retailer in the country, Sears accounted for only 3% of Whirlpool's sales worldwide last year.
In September, Lampert proposed that Sears restructure its finances without filing bankruptcy. But he warned that the company was running out the cash. The company's stock quickly fell below $1 a share for the first time in its history.
Creditors opted instead to try their hand in bankruptcy court. Without a deal and with $130 million in debt payments due Monday, Sears filed for Chapter 11 bankruptcy protection.
The brand that shaped a nation
Sears was once the nation's largest retailer and its largest employer. In its heyday it was both the Walmart and Amazon of its time.
Formed in 1886 by railroad station agent Richard Sears, the company started as a watch business in North Redwood, Minnesota. Sears moved to Chicago in 1887, and he hired watchmaker Alvah Roebuck as his partner. The first Sears Roebuck catalog, which sold watches and jewelry, was printed in 1896.
The Sears catalog was the way many Americans first started to buy mass produced goods. That was an enormous shift for people who lived on farms and in small towns and made many of the goods they needed on their own, including clothes and furniture.
Sears' stores helped reshape America, drawing shoppers away from the traditional Main Street merchants. Sears brought people into malls, which helped to lead to the suburbanization of post-World War II America. Its Kenmore appliances introduced many American homes to labor saving devices that changed family dynamics. Its Craftsman tools and their lifetime guarantees were a mainstay of middle-class America.
Sears truly changed America.
But long before the rise of Amazon and online shopping, Sears was struggling to keep up with changing shopping habits of Americans. Big box retailers such as Walmart beat it on both price and merchandise selection.
In 1999, it was booted out of the Dow Jones industrial average, where it had been for 75 years. Big box rival Home Depot took its place.
Sears and Kmart merged to form Sears Holdings in 2005. At the time, they had 3,500 US stores between them. They have fewer than 900 today.
In July, Sears closed the last store in Chicago, once its hometown. In August the company announced another 46 store closings. The company had 89,000 employees as of February. That's down from 317,000 US employees in early 2006, soon after the merger.


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Minneapolis, Minnesota
Hope Academy is a K-12 private school located in Minneapolis. Our mission is to foster hope in God within the inner-city neighborhoods of Minneapolis by providing youth with an outstanding Christ-centered education.
Teen Challenge offers Christ-centered, faith-based solutions for youth, adults, and families struggling with life-controlling problems, such as addiction.
These two entities at 2300 Chicago Avenue, Minneapolis have immediate opening for Building Maintenance Support.
This is a full time, year-round position with full benefits and is responsible for supporting and reporting to the Hope Operations Manager and the Building Engineer. This person must be available to work during the day to late afternoon, Monday-Friday for 40 hours per week. In addition, this person may need to be available periodically for on-call nights and weekends for emergencies.
Qualifications for this position include:
• Mechanical aptitude
• Minimum one to two years maintenance/mechanical/HVAC experience, or related technical education and certification
• Knowledge of educational/commercial building structures with knowledge of codes preferred
• Open to working towards and attaining a boiler license
• Good physical condition, able to lift a minimum of 50lbs regularly and 75lbs occasionally. Ability to perform following actions for the duration of an entire shift: walking, twisting and turning, stooping and bending, gripping, working with arms over one's head, climbing ladders and working at heights. Physician verification may be required
• Effective verbal and written communication skills in the English language
• Ability to work independently and with a team; good interpersonal skills
• Ability to follow written and verbal instructions
• Ability to positively interact with K-12 school students, teachers staff and administration, parents and school guests
• Excellent organizational skills and attention to detail, with the ability to effectively prioritize
• Willingness to learn and ready to accept new challenges
• Flexible and able to multi-task
• Valid MN driver's license
• High school graduate
• Basic computer familiarity
Primary Duties:
• Address and complete work orders and projects, including working with outside vendors and contractors
• Provide support in the operations and maintenance of all building HVAC systems, including boilers, chillers, cooling towers, pumps, ventilation units and other plant-related HVAC systems
• Help test and maintain building life safety (fire detection and alarm & fire sprinkler), emergency lighting, fire extinguishers and security systems
• Provide and follow a regular schedule of building inspection and preventive maintenance as directed by Building Engineer
• Help maintain building plumbing, lighting electrical, doors/locks and other systems and equipment
• Provide support for school staff with requested maintenance and tasks
• Provide leadership for Hope Academy safety drills and reporting as appropriate to proper authorities
• Assist Hope Academy management in other duties as assigned including but not limited to managing and planning for usage of floor space and school vehicle policies and procedures
• Provide light cleaning and trash services
• Assist in the documentation of work and maintenance performed, including detailed log sheets on all appropriate equipment
• Support the Building Engineer in completing projects and perform all tasks necessary for the day-to-day operation of the facility
• Positively communicate concerns or needs to the Building Engineer
• Serve as an example of Hope Academy /Teen Challenge in support of their mission, strategies and initiatives
• Take on oversight of building in the absence of the Building Engineer
• Salary dependent upon qualifications
• Subject to satisfactory background checkIf Interested:
• Please email staff application (http://hopeschool.org/wp-content/uploads/2016/06/Staff-Employment-Application-Form.pdf), resume, and cover letter to [email protected]
• All faculty and staff agree to abide by our Statement of Faith and our
Faith & Life Covenant. Before applying, we encourage you to read the following statements:


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The Samsung Galaxy Nexus has arrived and it's got Android's new Ice Cream Sandwich OS on board. The Nexus has the privilege of being the first smart-phone to run Google's brand new Android 4.0, which has been designed for both phones and tablets and incorporates the best bits of Google's previous Honeycomb and Gingerbread OS's.
The Samsung Galaxy Nexus certainly sounds impressive on paper and aside from its new OS, it features another first – a true 1280x720p resolution screen, which produces the crispest of images on its lovely little 4.65-inch display.
With Apple's new iPhone 4S providing its users with an 8MP camera, it's a bit disappointing to find that the Samsung Galaxy Nexus only offers a 5MP camera. However, it should be noted that its superb shutter speed helps to deliver effortlessly beautiful pictures.
One of the more intriguing features of the Samsung Galaxy Nexus is Face Unlock. Instead of typing in an easily forgotten PIN number, you use the phone's front facing camera to recognise your face, ensuring that only you (and maybe your identical twin) can unlock the phone.
It's an interesting idea, but perhaps somewhat hard to consider this as anything more than an adventurous gimmick. It's a polished piece of equipment and the ability to see emails, texts, tweets and voicemails in one notifications area really adds to the phone's usability.
The phone will hit stores on November 17 with the sim free model currently retailing at a hefty $750 (£549).


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You may have noticed that Pixar didn't release a movie this year. This is the first time that's happened since 2005, and it's due to the fact that the studio instituted a director change on its original 2014 film, The Good Dinosaur, fairly late in the game, resulting in a pretty significant overhaul of the story. The film will finally hit theaters next fall with co-director Peter Sohn stepping into the director's chair to tell the story of a dinosaur named Arlo who, after a traumatic event unsettles his family, sets out on a journey with an unlikely companion—a human boy. The buddy comedy takes place in world in which the dinosaurs never went extinct, and this new piece of concept art offers up a striking tease of the kind of visuals we might expect.
Check out the new The Good Dinosaur concept art and official logo after the jump. The voice cast includes Lucas Neff, Bill Hader, Neil Patrick Harris, John Lithgow, Frances McDormand, and Judy Greer. The Good Dinosaur opens in theaters on November 25, 2015.
Here's the official synopsis for The Good Dinosaur:
"The Good Dinosaur" asks the generations-old question: What if the asteroid that forever changed life on Earth missed the planet completely and giant dinosaurs never became extinct? In theaters November 25, 2015, the film is a humorous and exciting original story about Arlo, a lively Apatosaurus with a big heart. After a traumatic event unsettles Arlo's family, he sets out on a remarkable journey, gaining an unlikely companion along the way – a human boy. "The Good Dinosaur" is an extraordinary journey of self-discovery full of thrilling adventure, hilarious characters and poignant heart.
Images via Disney. Click to enlarge.


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A welcome boost from Greenwich Hospital
HighGround's fundraising for the Horticultural Therapy Challenge received a welcome boost this week with a generous donation from Greenwich Hospital. The move to the new DNRC later this year will be a big expense for HighGround and this donation will help with the transition costs.
Hugh Player, Director of Greenwich Hospital, the Royal Navy's Crown Charity said: 'We recognise the value of HighGround's horticultural therapy and are keen to both encourage and support the charity in this excellent work. We are confident that the transfer from Headley Court to the new facility at Stanford Hall will go ahead as planned, and that HighGround will therefore be able to continue bringing benefit to those who need this therapy to assist in their rehabilitation.' For more information about Greenwich Hospital visit: www.grenhosp.org.uk


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Monthly Archives: September 2013
Running With Bulls Tempranillo 2011, Barossa, SA
$20 from Bottega Tasca (Lygon St), $18.50 from Auswine. Intense black ruby colour with a slight purple-garnet rim. On the nose, I'm getting light, lifted rose florals, but then there's a slight disconnect with deeper black raspberry candy, anise and … Continue reading
Posted in Daily happenings Tagged 2011, Barossa, Barossa Valley, Running With Bulls, Sam Wigan, South Australia, Tempranillo, Yalumba Leave a comment
Plantagenet Omrah Sauvignon Blanc 2011, Great Southern, WA
$18.50 direct from winery, though members pay closer to the $16 found at DM's. This one's got a bit of age on it, although you're very unlikely to pick it out. The current vintage is 2012. Very pale yellow tinge, … Continue reading
Posted in Daily happenings Tagged 2011, Cath Oates, Great Southern, grilled prawns, Omrah, Plantagenet, salad, Sauvignon Blanc, Western Australia Leave a comment
Taltarni Brut 2010, Pyreness, VIC (multi-regional sparkling)
Taltarni operates out of the Pyreness, VIC but the fruit for the vintage Brut is sourced from multiple states, namely Victoria (65%), South Australia (24%) and Tasmania (11%). Produced using methode traditionnelle, i.e. fermented in bottle to achieve dissolved carbon … Continue reading
Posted in Australia, Daily happenings, South Australia, Tasmania, Victoria Tagged 2010, Brut, Brut Taché, Chardonnay, Pinot Meunier, Pinot Noir, Pyreness, SA, Sparkling, Sparkling Brut, Taltarni, TAS, VIC, Vintage Leave a comment
Seppelt Salinger Vintage Cuvee 2009, Great Western, VIC
Made from Chardonnay (63%), Pinot Noir (28%) and Pinot Meunier (9%), and includes up to 5% aged reserve wines for added complexity. This is a multi-regional wine, with fruit sourced from the cool climate sparkling regions of Henty (70%), Adelaide … Continue reading
Vasse Felix on the shelves, the eagle lands
Bit of a wet cold spell sweeping through Melbourne at the moment, so what better than a curry night at a friend's place (no washingup, hey score!). We had just been to Enoteca Sileno looking for some Italian biancos, but … Continue reading
Posted in Australia, Daily happenings, Margaret River, Western Australia Tagged 2010, 2011, 2012, Cabernet Sauvignon, Chardonnay, Margaret River, Merlot, Sauvignon Blanc, Semillon, Vasse Felix Leave a comment