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SaaS Comes at You Fast
SaaS Comes at You Fast
These days, it seems only a software-defined application delivery platform can keep up with the needs of multi-cloud and dynamic infrastructure.
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It's an exciting time to be software! Chances are you were brought into the world through continuous delivery, making a loving team of DevOps parents very proud… and very, very happy. Your potential is unlimited! The only thing that could possibly prevent you from growing up to fulfill your SaaS destiny is a poor application delivery strategy.
Your Grandfather Was a Monolithic App
In a simpler time, maybe five or six years ago, applications were monolithic in nature, making delivery a straight forward process. That's no longer the case, as today's modern apps are distributed and often powered by microservices like containers or cloud services. DevOps teams these days need to make sure every component of the application is performing as expected. But that's just the start, as they also must make sure the connective tissue of these distributed apps isn't underperforming, which could create a terrible end-user experience. Software-defined application delivery allows you to decide exactly how you want your application to be experienced by the end user, and easily write contingency-based code to implement those rules. Changes to your application architecture aren't a major concern since your rules can accommodate both planned and unexpected changes.
Your Generation Is Right at Home on Heterogeneous Infrastructure
Like applications, modern infrastructure has also changed significantly in the last several years. No longer are you using a single data center, or perhaps a data center and one CDN to make sure your app gets to your customers. Multi-CDN infrastructures allow you to re-route app traffic when performance is an issue. Multi-cloud environments are becoming more and more prevalent as enterprises want to avoid public cloud vendor lock-in and gain more control over their critical shared infrastructure. And of course, the data center you purchased a few years ago isn't just gathering dust…you paid for it, so you're using it. The net result is a heterogeneous set of infrastructures being used to deliver you to customers.
Kids Today With Their Dynamic Infrastructure
Even if your infrastructure is fully built out and provisioned, it is, by the nature of the cloud, constantly changing as instances are both spun-up and de-provisioned. Often, and for many reasons, this happens without you explicitly knowing about it. Software-defined application delivery helps you optimize your infrastructure in its current state, again using the business rules you decide on. This has the additional benefit of giving you a better idea of how to plan for cloud capacity and avoid overpaying since you can automate delivery based on your reserved instances and fully utilize the capacity you paid for. Your Software-defined application delivery also accounts for changes in cloud provider pricing and specific geographic needs, keeping the end of month bill surprises to a minimum.
Moving Sucks
There aren't any shortcuts when it comes to migrating applications to the cloud. The first step in cloud migration needs to be making sure your application can be delivered to your worldwide customers before, during, and after the migration. Do you really want to do that manually, while in the middle of a migration? Software-defined application delivery systems make sure your app reaches customers at all times.
Learn to Speak a Multi-Cloud Foreign Language
There are plenty of reasons to shift to a multi-cloud infrastructure plan: avoiding cloud lock-in, protection against massive cloud outages, leveraging certain vendor-specific services or offerings, and good old fashion Cloud SLA negotiation leverage. But once you've made the decision to add a second cloud vendor to your infrastructure, it's time to start thinking about how to ensure your app delivery is optimized for multi-cloud environments. Having your Ops team do so manually with each vendor isn't likely to be a popular strategy. The only way to manage delivery is with a software-defined abstraction layer on top of both clouds. Your Software-defined application delivery speaks both cloud "languages", and does all the translating for you, automatically.
Your Grandfather's Application Delivery Controllers Can't Keep Up
Remember the monolithic app? Its best friend was the Application Delivery Controller (ADC), also built for a different age. Often built into a blinking hardware box in a data center, old guard ADCs had several drawbacks. They required a significant upfront expense, as opposed today's cloud pay as you go model. Monitoring was done with synthetic testing only, not the combination of real-user and synthetic monitoring many software-defined application delivery solutions provide today. Most importantly, ADC solutions were not as easily configurable and customizable as the robust software-defined application delivery, making them unusable with today's modern application architecture.
Get in a Routine
As more and more concerns (security, DevOps, new technologies, etc.) are added to the Ops team's list of things to worry about, the need for process automation becomes paramount. Software-defined application delivery automation has the very practical effect of removing many common delivery issues, such as micro-outages, service degradations, and the occasional (and highly newsworthy) public cloud outage from the "worry" list. Your uptime and customer experience should all be ensured by a set of routing rules you determine ahead of time. You can't put a price on peace of mind, or not getting a million "OUR APP IS DOWN!!!!!" emails.
SaaS Comes at You Fast
Outages and cloud service degradation happens, so you need a plan in place for when they do. Many companies choose to utilize multiple cloud providers to ensure their application is always available to worldwide customers, even during an outage. Taking control over changes in public cloud service offerings, pricing models, and SLAs is another powerful motivator for Ops teams to move to a multi-cloud architecture. Software-defined application delivery allows you to seamlessly and automatically deliver applications over multiple clouds and/or CDNs, factoring in real-time availability, costs structures, and application performance.
There's No Fate But What We Make for Ourselves
There's no way you can keep up with constantly changing applications, the infrastructure they're built on, and inevitable network issues with manual processes. Software-defined application delivery allows you to implement the business rules that you know are important to the app delivery process, and do so instantly and automatically via customizable code. End user experience, network latency, unplanned cloud provisioning or CDN bursting, and other considerations can all be factored in as your needs change. The multiple application delivery fail-safe layers will keep you insulated from the outages that need to be mitigated during your Game of Thrones viewing.
Opinions expressed by DZone contributors are their own.


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2020 Ford Ranger Engine, Interior and Price – After many years of gossips and speculation, Ford verified in Jan that the lengthy-standing upright Ranger would go back to the U.S. marketplace. Stopped in 2011 following close to 30 many years in services, the Ranger left a void in Ford's ranks. Ford says that without small or mid-sized trucks, purchasers are only going to switch to their whole-measurements F-150 entrance-levels edition. Content with the F-150 chart-topping gross sales and predicting the mid-size-van sector is virtually dry, Ford seems to be satisfied permit Toyota, Nissan, and aging Standard Motors stabilizers fight with the getting smaller current market. However GM faked it accurately and created the newly released Chevrolet Colorado and GMC Canyon trucks for 2015, and two strong and cheap shields sold far better than any person had required. When Honda helped bring his Ridgeline again, Ford required to recover into play.
2020 Ford Ranger Redesign
Exterior and Interior Design
More than just an extra gross sales electrical generator, compact trucks are adored by weekend fighters on the outskirts of the community who love job-in a positioning motor vehicles as well as camping outdoors, kayaking, classic, garden, and the periodic drywall endeavor while not a track down of the entrance from the comprehensive-dimensions truck. With the Ranger coming back, Ford will once more have lorries for people purchasers, as well as for people who move up from the car and try to get out the whole-sizing truck, just before defecting for other manufacturers. The household ranger shall be linked to overseas Ranger and brought to life by Ford Sydney and purchased in some promotes near the planet. Right now booked to get constructed at Ford Michigan Installation Place in Wayne, the new Ranger will feature a gentle revision on the international body-on-framework model platform to optimize it in home projects.
Ford has proved that the Ford Ranger 2020 is going to be an ordinary body-on-body truck according to a global pickup platform since nameplate resides all around the entire world following being balked on the U.S. once the 2011 model year. Many years ago, the F-100 model was rumored to become a feasible admittance-levels exchange, but the Ranger label has survived (in the U.S. and offshore) to view other years.
Mainly because of the outer walls, it is, however, challenging to know whether or not the new pickup will vary considerably from its brothers and sisters abroad. No less than we hope to determine some design cues that will help tie up it to large F-Series versus related car forms concerning trucks outdoors the United States. What the Ford Motor Company needs to say on the subject of the North United states Ranger to date is that output will start at the Michigan Convention Vegetation at the conclusion of 2018, with a body-on-body Bronco for being added in 2019 for the 2020 model year.
2020 Ford Ranger Engine
You count on 2020 Ford Ranger to produce the Ranger with a 2.3-liter inline-several EcoBoost turbocharged as a standard powerplant and to take advantage of the 2.7-liter EcoBoost or 3.5-liter V-6 engine for premium or sports models. Ford can even call them by natural means aspirated 3.7-liter V-6 for reduce-charged models, and diesel ability comes in an inline-your five 3.2-liter form now used in Transportation vans or 3.-liter V-6 diesel into 2018 F-150, both equally of which are badged Electrical power Stroke. At this moment, it's not clear how or when the new instant ten quickness Ford auto gets into the situation, but it is a good guess that the automaker will need to make use of it inevitably in many models with longitudinal orientation equipment as it must be. The rear variation, several, as well as even all-wheel-drive will probably be supplied.
2020 Ford Ranger Price and Release Date
We expect to see the vehicle to gain access to the sector at the conclusion of 2019. After the release of the prior decades, we predict the price of 2020 Ford Ranger sets out from $30.000. If there are changes, we are going to notify you promptly. So, abide by our weblog improvements.

subset: commoncrawl


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|Tournament Description
The Tampa Bay Sportsplex is proud to host the National Hockey Festival during the Thanksgiving Holiday. As on the biggest Field Hockey events in the world, Festival attracts over 7,000 visitors from the US, Canada, Europe and Caribbean. Please read below when each division's registration opens and for more information on pricing and payment processes.
The 2019 National Hockey Festival features play for U-12 Co-Ed (7v7), U-14 Girls (7v7/11v11), U-16 Girls (11v11), U-19 Girls (11v11), U-19 Boys (7v7) and Adults in an Open and Mixed Division (11v11).
College Coaches attend Festival! Over 105 Colleges reported for the 2017 National Field Hockey Festival. To see last year's attendance click here.
Registration Guidelines:
Registration for the 2019 National Hockey Festival will be conducted in two separate sessions. The first session, opening on April 12th, 2019at 12:00pm EDT, will allow clubs to register for only the U-12 Co-Ed, U-14 Girls, U-16 Girls, U-19 Girls divisions. During this first registration session, clubs will only be allowed to register one team per club in each of the Divisions so that well-rounded club diversity can be achieved in our most popular divisions!
Beginning on April 26th, 2019 at 12:00pm EDT, a second registration session will open that will allow clubs to register teams across all U-12 Co-Ed, U-14 Girls, U-16 Girls, U-19 Girls, U-19 Boys and Women's Adult Open and Mixed Divisions with no restriction on the amount of teams that can be registered until the divisions are at capacity or the initial registration deadline of June 28th, 2019 at 11:59pm EDT. Teams that register after a division is full or after the registration deadline will be put on a waitlist.
*Registration information for ancillary event offerings, such as player, coach and umpire development opportunities will be communicated in future pre-event email communication.
Stay To Play:
With hotels being in high demand during Thanksgiving weekend in the Tampa Bay area, USA Field Hockey has teamed up with Team Travel Source as the official housing provider to make sure the best quality hotels are available during this time of year at the best possible rates available. Teams may start reserving room blocks upon the registration opening date by clicking here or by contacting
Pricing Information:
Pricing for age divisions will vary per division, please see below a breakdown of each division's registration fees. A deposit option will be available for teams when they register so that full registration payment is not due up front when registering. U-19 Girls and U-16 Girls registrations will be eligible for a $500 deposit while all other divisions are eligible for a $300 deposit option. *Deposits are nonrefundable. Refunds will not be granted after the registration deadline of June 28th. Full payment is due August 3rd.*
Division Information
U-12 Co-Ed teams will be placed in pools with like rating. There will be a rerating persion for this division, before the schedule release. 6 game guarantee!
U-14 Girls, U-16 Girls, and U-19 Girls teams will be placed in a pool snaked by rank. 6 game gaurantee!
U-19 Boys, Women's Adult Open, and Mixed will have a 6 game maximum. The minimum game count is dependant on final registration numbers.
Roster Information:
Roster Deadline: Friday, October 25, 2019 at 11:59pm EDT. *A late fee will be applied after this date
Roster Lockdown: Friday, November 15, 2019 at 11:59pm EDT.
*You will still be able to edit your roster until the lockdown date.
Contact Information:
We are excited to be partnered with the Tampa Bay Sports Commission to help USA Field Hockey execute a well-rounded event experience in the Tampa Bay Area. For more information on the Tampa Bay, Fla. area, please visit their visitor's website here.
Need more information on the National Hockey Festival? Please contact Madeline Hoeppner, Event and Club Services Manager, at firstname.lastname@example.com
About USA Field Hockey
|Location & Contact Information
Last Updated: 7/7/2020 1:29:56 PM


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Currently Out of Stock
- Product Details
- Specifications
- History
- Sell Silver to Us
- Why Buy Silver
One of only 9 MS-70 First Strike examples certified by PCGS!
Coin Highlights:
- Contains 1 oz of .999 fine Silver.
- PCGS encapsulation guarantees the coin's perfect MS-70 condition.
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- Obverse: Adolph A. Weinman's design showing Lady Liberty draped in an American flag, walking gracefully as the sun rises over a ridge.
- Reverse: A heraldic eagle is shown below 13 small stars, representing the original colonies.
- Sovereign coin guaranteed by the U.S. government.
- QA Check sticker reveals this coin's quality and grade have been verified by a trusted and reputable third party. QA check stickers are the modern's coins equivalent to the CAC sticker.
Display your certified Silver American Eagle in style by adding an attractive presentation box to your order.
One of the most popular designs in American coinage, the Silver Eagle combines beauty with Silver bullion appeal. Add this beautiful, rare Silver American Eagle to your cart today!
Investment and Collection Potential of Silver EaglesOf all the Silver bullion produced by the U.S. Mint, the Silver Eagles might offer the most value. They appreciate quickly thanks to their beauty and collectibility, and their long-standing quality has enchanted numismatists for decades. The Silver Eagle features Lady Liberty with a flag flowing around her shoulders on the obverse and an eagle with a shield on its chest on the reverse.
Iconic American symbolism dominates both surfaces. In addition to the Walking Liberty image and the eagle depiction, you will also notice the 13 stars that hang over the eagle's head and the U.S. motto written across the eagle image. Plus, the words "United States of America" appear on the reverse along with the coin's legal tender value and its rating as fine Silver.
First Strike Silver Eagles Offer Tremendous ValueAll Silver Eagles feature 1 oz of .999 fine Silver, which is the finest Silver offered by the U.S. Mint. Additionally, PCGS has given these Mint State coins a rating of 70, which means the grading experts detected no post-production imperfections at five-times magnification.
If you decide to invest in First Strike Silver Eagles, you will get the most value. These early release coins travel from the U.S. Mint to PCGS within 30 days, so they retain their beauty and offer the finest luster. Additionally, Mint State coins often offer better appreciation rates than Proof coins.
APMEX takes pride in being one of the most innovative companies in our industry. In true innovation, we leveraged partnerships with the top coin grading agencies to create CoinGrade+®, providing relevant numismatic information, synced daily with third-party grading services, ensuring you have the most up-to-date information available.Learn More
|Coin ID
The total number of coins produced at a specific mint for a particular date and mintmark combination.
|Graded Higher
The total number of coins that have obtained a higher grade than the subject coin by a particular grading service.
|Mint Mark
|N/A - Not Available
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We provide all of our customers with a refund, return and / or exchange on everything we sell including all bullion and certified coins. If for any reason, you have a problem, please feel free to call us. We will always do our best to accommodate you.


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|Project by Orvile Baker
|posted 04-29-2018 01:53 AM
|3350 views
|1 time favorited
|13 comments
Just a little something to let you all know I am healing up .Hand is doing good , cast comes off on the 9th. then we will know how soon I can get back into the shops. I am going nuts not being able to work. mI made these for the grandkids so they will have something to do while I fish this summer. Scraps from cleaning the shop, nothing special.
-- Bud Baker , Ojibwa, WI. http://papabudswoodtoys.webs.com/
13 comments so far
#1 posted 04-29-2018 01:58 AM
Great to hear you're on the mend Bud.
-- Lifes good, Enjoy each new day...... Cheers from "On Top DownUnder" Crowie
#2 posted 04-29-2018 02:37 AM
#3 posted 04-29-2018 03:33 AM
My goodness a whole fleet of them Cool!!! lol
-- An Index Of My Model making Blogs https://www.lumberjocks.com/htl/blog/130264
#4 posted 04-29-2018 08:00 AM
Just a little something to let you all know I am healing up
Great to hear.
#5 posted 04-29-2018 04:51 PM
Nice fleet "Admiral".
Making a navy . Is something to do.
I do realize the "can do nothing" will drive anyone over the edge! I can barely tolerate decent TV; let alone the GARBAGE my wife likes.
-- Wood rescue is good for the environment and me! just rjR
#6 posted 04-29-2018 06:27 PM
I hope that you will recover very well and get back to the shop as fast as possible. That's a nice toy boat.
-- helluvawreck aka Charles, http://woodworkingexpo.wordpress.com
#7 posted 04-29-2018 07:21 PM
Hey Bud. I also am gaining strength, allowed out of bed but not in the garage yet. Keep up the good fight.
-- DonB
#8 posted 04-29-2018 09:32 PM
Hey Don hang in there bud , we will both be back in the shop soon. I get my cast off on the 9th then 6 week working the hand to work right (I hope) then back to work. So hang in there and I am sure" we will be back"
-- Bud Baker , Ojibwa, WI. http://papabudswoodtoys.webs.com/
#9 posted 04-29-2018 11:02 PM
Nice use of different colored lumbers.
-- Dick, Malvern Ohio - my biggest fear is that when I die, my wife sells my toys for what I told her I paid for them
#10 posted 04-30-2018 12:30 AM
You say nothing special, your to humble. That's a great looking toy. Very creative in your design and that makes for a super toy. Thanks for inspiring
-- CurleyJoe, "You only learn from your mistakes"
#11 posted 04-30-2018 04:45 AM
It's good to see that the fleet is sailing off- so I bet new ships are coming.
-- Ivan, Croatia, Wooddicted
#12 posted 04-30-2018 01:39 PM
Looks like you are back in the shop. doing well for a one arm bandit
-- Brian - Hazelton, British Columbia
#13 posted 04-30-2018 01:56 PM
im so glad your back on the mend ….i been missing your projects Bud …GREAT JOB :<)) GRATZ TOP 3
-- Tony---- Reinholds,Pa.------ REMEMBER TO ALWAYS HAVE FUN
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To see more photos of the completed loom, check out our other post here, or to see the loom in action see our video on YouTube. Connect with us on Facebook .
Suggested materials:
at least 2 large strong tray-style cardboard boxes (plus some extra cardboard for beams and some other parts)
a packet of bamboo skewers
8 small fishing weights (we had none so we used metal washers instead)
4 small bulldog/binder clips
fine strong thread (for example size 10 crochet cotton)
twine or strong yarn (not too slippy or thick)
pvc tape or duct tape
double-sided tape
strong glue
Pack of strong velcro (hook and loop fastener) stickers
a scissors
a darning needle
a book or other heavy object (to hold the reed in place while you are making it).
A note about materials:
The list above shows the materials we used purely because we had most of them lying around – the only things we actually bought were double-sided tape and velcro. If you don't have the same materials we'd encourage you to be creative and adapt the design to use whatever you have available. The real joy of this project is in the creation of 'something from nothing'!
A note about measurements:
We purposely left out measurements from these instructions. We used our materials to guide us, and suggest you do the same.
The parts of a loom
Loom – A device used to hold yarn under tension so that cloth can be woven.
Castle – The vertical part of the loom.
Frame – The supporting part of the loom which holds the castle in place.
Warp – The long yarn threads that are held under tension on the loom (shown in red and yellow).
Weft – The yarn that is passed over and under the warp threads by the weaver to build up cloth. (shown in purple)
Beams – The warp threads are wound onto the warp beam. They then run over the back beam, and through the castle. In front of the castle the weaver adds weft to build up cloth. The cloth then runs over the front beam and is collected on the cloth beam.
Reed (and beater) – The reed controls the width of the warp and keeps the warp threads evenly spaced. The beater is used to move the weft into place. In this loom the reed and beater are combined into one piece.
Heddles – Each warp thread is threaded through a string heddle. When the heddle is raised, it causes the warp thread to be raised.
Shaft – The shafts hold groups of heddles. The shafts can be raised in various combinations so that different groups of warp threads are raised at different times. This loom has 4 shafts that hang in the castle (only 2 shafts are shown in picture).
Shed – The vertical space created between groups of warp threads when one or more shaft is raised.
Shuttle – The shuttle is loaded with weft yarn and passed through the shed by the weaver.
How to build your loom
The Frame
Trim any tabs and cover up any rough edges by adding some light cardboard to the sections shown above in yellow (use glue or double-sided tape).
Velcro is composed of two strips of fabric, one is made up of hooks (feels rough to the touch) and the other is made up of loops (feels softer to the touch). Turn box upside down. Fix strips of the hooked side velcro to the back and underside, as shown by the red areas above.
The warp and cloth beams
Using a square knot, tie a length of strong yarn near to the end of one skewer. (For instructions on how to tie a square knot see here.)
Use this yarn to lash on a second skewer. Do this by looping it around both, as shown above, until you reach the end. Secure the yarn to the first skewer with a square knot.
Cut a piece of stiff cardboard (if you wish you can glue multiple layers together for added strength). The piece should be the same width as the loom. Add velcro (looped side) to the end sections shown in red. Do this on both sides of the piece of cardboard.
Finally, using pvc tape or duct tape (shown above in blue), tape the first skewer to the cardboard beam. Use plenty of tape and wrap the skewer tightly to the beam in multiple places. Repeat so you have 2 beams.
The Castle
Cut a box in half
Cut a section out from each half as shown. Slot one half inside the other and secure with double-sided tape or glue.
Place your castle inside the frame – you will need to allow the frame to bend slightly so the castle can fit. Secure it firmly with plenty of double-sided tape and/or glue.
Bar for hanging shafts
Many cardboard boxes have a handle hole in the section marked by the red circle at the top of the castle. If there is none, cut one out. This is where you will place the bar for hanging the shafts.
Insert a skewer through the corrugation, as shown above. Push it all the way through, and trim away any excess.
The lifting mechanism (part 1)
Cut out a piece of cardboard to fit on the side of the castle in the position shown above by the red circle.
Make it at least 2 inches tall, and fold it as shown above.
Cut a second piece about 1 inch tall and glue it where shown above in red. Place it so the bottom edge is slightly lower than the fold line. This will stop the platform bending up too far. Glue the platform in place on the side of the castle. Make a second platform and set aside for later.
The Heddles
The picture above shows a cardboard heddle jig on the left and a string heddle on the right.
The height of the heddles depends on the beam height (shown above). Work out your heddle height as follows:
Heddle height = [beam height – 1½"]*2
( Metric: Heddle height = [beam height – 38mm]*2 )
Use your calculated heddle height to measure the distance between the top and bottom notches. Cut 6 notches in total as shown above.
Lay a length of strong thread so the midpoint is in the first notch. Tie a square knot (see instructions here) at each of the other notches. Be sure to keep tension on the thread between each knot, this will help ensure all your heddles are the same size. Slide the top loop of each heddle onto one skewer and the bottom loop onto another. One becomes the top bar of a shaft, the other becomes the bottom bar of the shaft. Repeat until you have the desired number of heddles on your shaft, then continue on a new set of skewers. Continue until you have completed heddles for all 4 shafts. We suggest 40 heddles per shaft, but feel free to choose fewer or more.
The shafts
On the top bar of your shaft move all heddles to the middle of the shaft. As shown above, use glue and some thick strong yarn/twine to make a stopper near the end of the bar. Make another stopper on the other side. Repeat for all 4 shafts. Leave some space at the outer edge so there will be room for the hanging cord. Repeat for all 4 shafts.
Take a length of strong yarn/twine and tie the ends together to form a loop, as shown above. Fold the loop in half and tie an overhand knot at the midpoint to form a smaller double loop.
Using lark's head knots (as shown above) attach the long looped ends to the top bar of your shaft, just outside the stoppers. The stoppers will prevent the cord from slipping toward the middle of the shafts.
Hang a weight from each side of the bottom bar. (If using washers then add a folded piece of cardboard to stop the washers swinging and knocking into the other shafts.) Move half of the heddles to each side of the shaft. Hold the shaft by the top loop so that it hangs freely. Adjust the position of the weights until the shaft hangs level, without dipping to one side. (Be sure that you don't move the weight too far from the edge of the bar, as they may then restrict the movement of heddles.) When you are happy with the positioning you can glue the weights in place.
Hanging the shafts
Tie a length of strong yarn/twine through the top loop of the shaft. Run the yarn along the path shown in red so it runs over the top bar of the castle, across the top of the castle and tie it to a binder clip on the top platform. Tie it so that the weights of the shaft barely touch the bottom of the loom. Repeat for all 4 shafts. You should place the 4 shafts as close together as possible, but not touching each other.
When you have hung all 4 shafts, tape 3 skewers (shown above in brown) to the top of the castle to separate the hanging cords as shown above in brown. Trim them down to size if necessary.
The lifting mechanism (part 2)
Now the second (lower) platform needs to be fixed to the castle. To choose the position, try lifting your shafts and observing the heddles. To lift a shaft unclip the binder clip from the top platform and pull it downwards. When a shaft is raised the heddle eyes should be at a height just slightly lower than the top bars of the lowered shafts. (If you wish you can wait until you have a warp on the loom to complete this step, then you can be absolutely sure of the correct positioning).
The reed
On the edge of a table lay a row of skewers side by side. Continue the row until it is about an inch shorter than the length of one skewer, ensuring that you have an odd number of skewers. Place a heavy weight, such as a large book, directly on top of the skewers to hold them firmly in place. (Please note that the picture above is not to scale – you will have a longer row of skewers!)
Push every second skewer to create a gap. (Those you push in will not be part of the finished reed, they are just used to create even sized gaps).
Place another skewer on top of the row as shown. Thread a darning needle with some strong yarn and use it to wrap this skewer to those underneath. Wrap very tightly and be sure to fill the space between skewers too. Add glue every inch or so as you progress.
To complete your reed repeat the glueing and wrapping process with a second skewer on the other end of the row of skewers. Make sure you remove the skewers that were used to create the gaps.
The shuttle
Cut out a piece of cardboard in the shape shown above (approximately 10 inches wide, or 25cm) to create a shuttle. Use tape to wrap it, covering any raw cardboard edges.
You have now completed your loom – congratulations!
In order to start weaving, you now need to prepare a warp and put it on the loom. There are many different ways to do this and many different resources you can consult.
An excellent book is:
Learning to Weave by Deborah Chandler
Here are some web-based resources for learning to weave:
Elizabeth Wagner's youtube channel
Weaving with Jette youtube channel
Facebook group 4-shaft weaving – we absolutely love this group!
If you enjoyed this post, please like and share!
We'd love to see your version of our loom – if you build one, please contact us and send pictures! We would be happy to answer any questions that you may have. If you are sharing your project online, we just ask that you include a link to our instructions.
Please do not reproduce or copy these instructions without permission, but feel free to share a link to our page!
Possible upgrades:
– Add a few layers of cardboard between the bottom of the box and the beam attachment points – this will allow more warp/cloth to be wound.
– For an 8-shaft loom just add 4 more shafts on the other side.
– Make the shafts "spring-loaded" by using elastic bands instead of springs.


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Cool projects
by Reiner Bronsgeest
Happy Lunar new year and a good February to all! When you do something twice it becomes a tradition. So here are my top picks for digital and technology projects that will be delivered this month:
• delivering a first live use case (>€3M savings annually) with our Proof-of-Value team for business use cases on a data lake #datascience
• completing the global integration of one high-tech company into the second #mergers
• finishing up a workload migration for dozens of applications from Azure to AWS #publiccloud
• a business case for global standardization of security systems in a tele-communications R&D company
Itility Cloud Control
by Geert Vorstermans
Happy new February! Sharing our ideas, deliveries and many small next steps towards innovation and becoming fully digital. Dream big, Start small!
February starts well, celebrating our 12,5 years anniversary at Itility! Our Itility Cloud Control team is looking forward to February 2019:
• working together with Dizain-Sync to support design and engineering applications
• starting 2 new cloud control foundation initiatives
• new pressure cooker session on SAP automation
• embedding cost control reporting in our cloud toolkit
• ... are you ready to start a journey together?
Training and culture
by Fleur Kappen
Happy February to all :-) And February at Itility is all about growth! Here you see what we have done/planned in February related to training, culture, and growth:
• we have celebrated our 12,5 year anniversary (woohoo!) with a special gift for all Itilians: seeds to continue growing an awesome future together
• we are currently designing our Spring School training, and at HQ we have a "training tree": here you can hang your training preferences in the tree. Grow your own future! (sneak preview of the Spring School topics: #Kubernetes, #AzureResourceManager, #SiteReliabilityEngineering)
• we are also designing a new leadership training together with experts Eddy Veugen and Anke van Luijt to grow and develop new leaders
• for sustainable growth and smart decision making, we've learned more about people analytics from the HR Analytics Academy and the KIN Center for Digital Innovation
• we grew our close partnership with Techwave further by means of a cool cricket match
Data Science
by Marianne Faro
February starts well, with celebrating our 12,5 years anniversary. Other goals for our data science team in February 2019:
• 4 data scientists from our YPP class to start working at customers KPN and ASML, and finalize hiring new YPP'ers for the class of March
• become an Amber customer/hub, so that our own way of booking the electric shared car will influence our Amber replenishment algorithm
• demo of our DevOps/DataOps/DataFactory way of working to Vanderlande
• connect with AVR to define next steps for an Azure DWH.
Make sure to subscribe below to stay updated about our monthly celebrations – directly into your inbox.
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text:
Retail chains – ACORT
members represent about 25%
of the market of retail trade
Moscow government thanks Dixy for conscientious work
On the eve of the fiftieth anniversary of the Day of Retail Worker, DIXY'S Group team received a letter of gratitude from the Moscow Mayor "For conscientious operation for the benefit of residents and guests of the city."
"It is a great honor for us to receive the gratitude and special recognition of our daily work from the Mayor of Moscow. Moscow and the Moscow Region are one of the key areas on DIXY's map, with several hundred stores concentrated in the city. This is where we launched an extensive company development program in order to satisfy the expectations of Moscow residents to the fullest possible degree. So today we are increasing our assortment efficiency, upgrading product quality control system, working on shopping experience improvement," says Pedro Pereira da Silva, President of DIXY Group.
The Group is represented in Moscow since 1999, when it opened the first neighborhood store. Today there are over 470 DIXY stores and thirty Victoria supermarket in the capital. Each of them helps to provide the residents with high-quality essential food products and creates jobs. Moscow stores and offices employ a total staff of over 12 thousand people. The company observes the RF Labor Code standards, provides comprehensive social protection and adequate wages. Besides, DIXY cares about the professional development of its employees, offering them all opportunities for advance training and career growth on the basis of the DIXY Academy in-house training center. It is attended on a weekly basis by approximately 700 employees.
DIXY Group stores actively participate in Moscow festivals. Victoria has supported the Fish Week and Moscow Jam municipal festivals for two consecutive years. Since February 2016, all Victoria stores in Mo successfully sell the Moskva cake, the recipe of which was developed upon the initiative of the Trade and Services Department of Moscow.
Also on the Day of Retail Worker, DIXY Group took part in the festive Race to Meet the Customer 2016. Employees from DIXY stores, offices, and distribution centers joined 2,500 representatives of retail chains operating in various formats and business areas to cover together the five-kilometer marathon distance towards new results and customers.


text:
Sean Costigan
Senior Associate
Sean S. Costigan is a strategist and technologist in diverse security and technology fields including cybersecurity and foresight.
Mr. Costigan advises governments and corporations on risk, cybersecurity and foresight. He serves as a Professor at the George C. Marshall European Center for Security Studies. His current work includes a US DOD-funded cybersecurity education initiative and consulting on cybersecurity, looking particularly at next generation challenges. Mr. Costigan has served as a team member of the Private Sector Program at the Office of the Director of National Intelligence, Chief Information Officer of The MIT Press,
Director for Strategic Initiatives, Center for Security Studies, ETH Zurich, and Visiting Fellow at the University of Calcutta's Institute of Foreign Policy Studies, among other posts. He teaches emerging security challenges and international affairs courses in the US and Germany. Mr. Costigan has previously served as an Executive Editor at Columbia International Affairs Online, Research Associate for Science, Technology and Defense Industrial Policy at the Council on Foreign Relations, and on the staff of the
Center for International Affairs, Harvard University. He is presently serving as a Senior Adviser to the NATO/GCSP/PfPC Emerging Security Challenges study group, co-chair of the Economics of Security Study Group, and Chair of the Editorial Board, Partnership for Peace Consortium of Defense Academies and Security Studies Institutes.


text:
B2B Lead generation In India has become a tough nut to crack in this era of intensifying competition and shoe-string budgets; one need to go beyond age-old tactics to be successful. The post stresses on providing value added services for attracting quality leads.
The Global Associates Lead Generation in India has become far tougher than a decade earlier with continuing economic slowdown forcing the companies to work on shoe-string budgets. A lot of companies rely now on outsourcing their lead generation job to experienced vendors; however, depending on the age-old tools is not enough to boost lead generation in India, you need to offer something extra, something special in order to woo the prospects. You need to ensure, for example that your vendor is providing qualified leads and not just a mailing list with names, addresses and phone numbers.
Simple mailing list vs. qualified lead:
Any business guru would tell you that you can easily get simple mailing lists online or buy them from any vendor without paying much. A qualified sales lead would be backed with some thorough research, useful information and deep insights about the organization to help you plan your strategy accordingly. Unless you have leads like this, you are only throwing away your money on some useless lists not worth a dime.
Qualifying leads:
If a company provides sales leads with minimal information without any proper research about the prospect's company or industry; forget about enhancing lead generation in India working with such leads. One need to be aware of a prospect's specific needs and pain points in order to judge their level of motivation level and it becomes impossible to prioritize such leads. The right way of qualifying a sales lead is to do a thorough research about their organization's needs and problems before even approaching them. You should try to contact the decision makers only after getting familiar with their background properly and try to ascertain their motivation level to buy from you. If their level of motivation is high enough; approach them for appointment setting which paves way for presenting your solution. A contact list is nothing more than a cheap mailing list without these insights and client specific information.
Remember, you need qualified leads with all the required information to be able to boost lead generation in India.


text:
17.4k in 2.5 Minutes!
This is straight out of our forum and was posted by uffrank. Much thanks to that GT5 fan! You can also check it out direct at the forum by clicking here.
First you will need to be at Level 12.
Second you will need a ride:
2006 Chevy Corvette Z06 (100k)
Tune it to 600 – 650 hp, Drop weight to stage 1, and buy some medium racing tires (50 – 60K)
Third the event:
Enter the Supercar Racing series in the Advanced Level, Select the Second track 3 laps at Daytona.
You will complete 3 laps flat out at 44-46 seconds a lap, and will earn 17.4k.
With loading time you can enter compete and win this race 3 times in 10 minutes for $52,200
You can also use this car for the American Muscle car series & earn the same 52k for 3 races, but it takes more time.
Quick cash is a beautiful thing isn't it?
Let us know if you have tried this or give it a go and tell us what you think!
Don't forget you can always check out new cheat in the forum or visit http://gt5cheats.com/forum
UPDATE: Here is a good Youtube video of how its done!
Thanks to msotelo09 for sending this through.. good work!
Tags: daytona cheat gt5, gt5 cash cheat, gt5 fast money, money cheat gt5, quick cash cheat gt5


text:
In This Section
Got Skills? What it Takes to be a Learning Health System Researcher
Don't let those crisp, white lab coats fool you. While researchers share the ultimate goal of reaching new findings that can advance the best possible medical care, they aren't all the same. Each investigator has a highly specialized knowledge base that is constantly changing as they apply new things that they've discovered, whether in the lab, at the bedside, or within an emerging field called the learning health system.
A learning health system engages patients, physicians, and researchers who together explore the wealth of health information available in large, shared data-sets that can be aggregated, analyzed, and quickly disseminated to inform individualized patient care decisions. A new article from the Agency for Healthcare Research and Quality (AHRQ) describes the unique skills that learning health system researchers need to be successful, and it identifies core competencies to guide their future training requirements and curricula.
The authors define a learning system researcher as: "An individual who is embedded within a health system and collaborates with its stakeholders to produce novel insights and evidence that can be rapidly implemented to improve the outcomes of individuals and populations and health system performance."
Christopher Forrest, MD, PhD, a professor of Pediatrics at Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, co-authored the article that appeared this week in Health Services Research. He explained that "embeddedness" is a distinguishing feature of a learning health system researcher.
"A learning health system researcher must be part of the system that he or she is studying, either as an employee or invited guest," Dr. Forrest said. "This embeddedness allows the researcher to execute scientific investigations in real-world settings in ways that do not disrupt day-to-day operations, and it ensures that the researcher understands the context within which the work is being done."
The AHRQ article was developed based on a literature review, interviews and surveys, and input from three expert panels that included researchers, practicing clinicians, patients, and health system leaders. It provides a list of 33 core competencies divided into seven domains of expertise as a framework for health systems to design, implement, and evaluate training programs for learning health system researchers:
- Systems science
- Research questions and standards of scientific evidence
- Research methods
- Informatics
- Ethics of research and implementation in health systems
- Improvement and implementation science
- Engagement, leadership, and research management
These core competencies could improve outcomes for children because pediatric research often requires multiple disciplines to work together to tackle healthcare delivery challenges. No single pediatric institution usually has enough patients to generate large numbers of study participants, so a national, pediatric-specific learning health system called PEDSnet provides access to diverse, nationally representative health information from millions of children. Dr. Forrest is the principal investigator of the research network that combines clinical data from eight children's hospitals, including CHOP, plus several specialty disease networks.
"PEDSnet was formed by leading children's hospitals in the U.S. to advance the learning health system model nationally in pediatrics," Dr. Forrest said. "The leaders of PEDSnet believe that one of the best ways to improve the outcomes of children and their families is to forge a national learning health system by collaborating across organizational boundaries on research and implementation of evidence. This is the vision that has been part of the DNA of PEDSnet since it was formed."
Find out more about AHRQ's development of a learning health system here, and about PEDsnet here.


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Hi friends! I survived the weekend in one piece. Being away from the kids and Ron wasn't as horrible as I thought it would be. I missed 'em terribly but I had lots to keep my mind busy at the Healthy Living Summit. I've been thinking about everything that I learned and observed over the weekend every since we left the hotel. My head is still swimming. I think the biggest thing that I took out of it all was "Where do I want to take Happy Fit Mama?" There's lots of options but I want to stay true to being ME. I'm still processing things so it is definitely a work in progress.
So where do I begin? Let's start off with my procrastination in packing. Cheryl and I had planned to leave around 2 pm. I thought that gave me plenty of time to pack. Too bad I didn't really start until 11 a.m. Then it was a panic. I brought WAY too much.
The trip down to Cambridge was great until we started following the Google maps directions. After circling MIT for at least 30 minutes, we finally made it to the Hyatt. Gah! We later learned from the front desk staff that Google maps is off in their directions. Lesson definitely learned!
We checked in right away and picked up our swag bags. Check out all the goodies!
And the best swag of all:
Reebok RealFlex shoes! The pair on the left is the original pair I got. However, a size 8 was too big so I thankfully was able to exchange them for a 7.5. I liked the gray but I really, really love the pink and green. So cute and extremely comfortable! I must admit that I have not bought anything Reebok in a long time (middle school, maybe?). But their new line is fantastic! I'm really digging the bright colors and cute strappy tanks. I see this tank in my future. Thank you so much Reebok!
After pouring over our bags we got ourselves all pretty for the cocktail party. We snacked, sipped wine and mingled for a couple of hours. I met some great bloggers including Stephanie.
Of course, we had to have some fun in the photo booth too.
Clearly, I love photo booths and props. 😉 Oh boy…
Saturday morning I ventured out for a easy 3 mile run with a lovely group of ladies along the Charles.
Dani, Rachael, Min, me, Danielle, and Phyllis
Rachael was actually my Foodie PenPal last month. It was great to meet her in person! My knee felt great during the run and I stuck to my promise of not going over 3 miles. Oh wait! Have I filled you all in on my knee situation? That will have to happen tomorrow. Stay tuned…
Anyway, back to Saturday at HLS. The day was packed full of food, speakers, and a CrossFit workout.
The workout put on by Reebok, CrossFit One and CrossFit New England was fantastic! Hands down that was the biggest highlight for me. After their workout, Cheryl and I picked the brains of 2 of the trainers. We talked about body mechanics and Paleo mostly. Don't worry, I'm not going Paleo anytime soon! I mean I love almond butter and sweet potatoes but my options as an almost vegetarian are pretty slim on Paleo. 😉 I may be looking into my local CrossFit Box very soon.
The speakers on the panels and sessions did a great job. I'm going to start implementing some of their tips very soon. Like I said before, my head is still swimming from all the information! I'll share my notes in the next couple of weeks.
Another highlight? Getting to meet the fabulous FitFluential CEO, Kelly Olexa! Blogger fail – no picture! 🙂 Trust me when I say she is just as great in person as on her vlogs and writing.
Before I forget, I have to give a big THANK YOU to the wonderful ladies from the Portsmouth lululemon store. They graciously gave me this awesome tee to where to HLS.
Isn't the back cute??!!! LOVE! It is so comfortable, too. Thank you so much ladies!
I'm so glad I had Cheryl with me to "hold my hand" during the weekend. We are both fairly new bloggers who didn't know anyone else going into HLS. I would have never made it without her. Thanks so much roomie! 😉
It was an interesting weekend to say the least. I was disappointed by a few things. However, it was just a reminder that I need to be ME in real life and on my blog. I'm sure I'm forgetting something that I absolutely had to recap but I'm drained. Don't be surprised to see random thoughts from the weekend popping up in posts for the next month. 🙂
Have a great Monday everyone!


text:
What experience do you have playing MMORPG games?
I have been playing MMORPG's now for the best part of 14 years , including WOW, EQ, EQ2, Vanguard SoH, Asheron's Call, Rift and many more.
What raiding experience (if any) do you have? Please give details.
Mostly with EQ2 before Velious, APW on vanguard, some raids on Wow and Rift.
Why do you want to join United Kingdoms?
I was part of United Kingdoms for a while in EQ2 on the Splitpaw server.
What are your goals when playing Pantheon? Please give details.
To enjoy the game to its max, play my chosen class well and to help others when needed.
Do you have a microphone to talk to other guild members via our voice chat server?
I do yes, but being a Geordie I prefer not to use it as noone understands me haha.
Do you have pre-alpha access to Pantheon?
Do you have alpha access to Pantheon?
Do you have beta access to Pantheon?
I believe I do have Beta access.
App: Magnos
Post your guild application here.
Post Reply
First unread post • 2 posts • Page 1 of 1
Re: App: Magnos
Hi Magnos,
As a former member of United Kingdoms you have been given full member access. Welcome back.
As a former member of United Kingdoms you have been given full member access. Welcome back.
Post Reply
2 posts • Page 1 of 1


text: The DiscipleShip Children's Ministry invites you to be a part of the Shipwrecked: Rescued By Jesus Vacation Bible School (VBS)! Preregister your kids (ages 3 to 12) or sign up to serve online by May 31st and you might win a VBS themed T-Shirt. You can also GIVE to help fund this year's VBS by putting VBS 2019 on an offering envelope or in the memo line of your check. Each servant will NEED to attend a VBS Servant's meetings after service on Thursday, June 20th.https://www.youareloved.org/thediscipleship/vbs2019.php


text:
Effective treatment of patients with locally advanced pancreatic cancer is a significant unmet clinical need. One major hurdle that exists is inadequate drug delivery due to the desmoplastic stroma and poor vascularization that is characteristic of pancreatic cancer. The local iontophoretic delivery of chemotherapies provides a novel way of improving treatment. With the growing practice of highly toxic combination therapies in the treatment of pancreatic cancer, the use of iontophoresis for local delivery can potentiate the anti-cancer effects of these therapies while sparing unwanted toxicity. The objective of this study was to investigate the impact of formulation on the electro-transport of the FOLFIRINOX regimen for the development of a new treatment for pancreatic cancer.
Three formulations of the FOLFIRINOX regimen (5-fluorouracil, leucovorin, irinotecan, and oxaliplatin) were generated at a fixed pH of 6.0 and were referred to as formulation A (single drug solution with all four drugs combined), formulation B (two drug solutions with two drugs per solution), and formulation C (four individual drug solutions). Anodic iontophoresis of the three different formulations was evaluated in orthotopic patient-derived xenografts of pancreatic cancer.
Iontophoretic transport of the FOLFIRINOX drugs was characterized according to organ exposure after a single device treatment in vivo. We report that the co-iontophoresis of two drug solutions, leucovorin + oxaliplatin and 5-fluorouracil + irinotecan, resulted in the highest levels of cytotoxic drugs in the tumor compared to drugs delivered individually or combined into one solution. There was no significant difference in plasma, pancreas, kidney, and liver exposure to the cytotoxic drugs delivered by the three different formulations. In addition, we found that reducing the duration of iontophoretic treatment from 10 to 5 min per solution resulted in a significant decrease in drug concentrations.
Underlying the difference in drug transport of the formulations was electrolyte concentrations, which includes both active and inactive components. Electrolyte concentrations can hinder or improve drug electro-transport. Overall, balancing electrolyte concentration is needed for optimal electro-transport.
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Folinic acid, 5-fluorouracil, irinotecan, and oxaliplatin
University of North Carolina
Liquid chromatography–mass spectrometry
Quality controls
Inductively-coupled plasma mass spectroscopy
- 1.
Garrido-Laguna I, Hidalgo M (2015) Pancreatic cancer: from state-of-the-art treatments to promising novel therapies. Nat Rev Clin Oncol 12:319–334
- 2.
Kleef J, Reiser C, Hinz U, Bachmann J, Debus J, Jaeger D, Friess H, Büchler MW (2007) Surgery for recurrent pancreatic ductal adenocarcinoma. Ann Surg 245:566–572
- 3.
Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, Madhu B, Goldgraben MA, Caldwell ME, Allard D, Frese KK, Denicola G, Feig C, Combs C, Winter SP, Ireland-Zecchini H, Reichelt S, Howat WJ, Chang A, Dhara M, Wang L, Rückert F, Grützmann R, Pilarsky C, Izeradjene K, Hingorani SR, Huang P, Davies SE, Plunkett W, Egorin M, Hruban RH, Whitebread N, McGovern K, Adams J, Iacobuzio-Donahue C, Griffiths J, Tuveson DA (2009) Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324:1457–1461
- 4.
Neesse A, Algül H, Tuveson DA, Gress TM (2015) Stromal biology and therapy in pancreatic cancer: a changing paradigm. Gut 64:1476–1484
- 5.
Byrne JD, Jajja MR, O'Neill AT, Bickford LR, Keeler AW, Hyder N, Wagner K, Deal A, Little RE, Moffitt RA, Stack C, Nelson M, Brooks CR, Lee W, Luft JC, Napier ME, Darr D, Anders CK, Stack R, Tepper JE, Wang AZ, Zamboni WC, Yeh JJ, DeSimone JM (2015) Local iontophoretic administration of cytotoxic therapies to solid tumors. Sci Transl Med 7:273ra14
- 6.
Byrne JD, Jajja MR, Schorzman AN, Keeler AW, Luft JC, Zamboni WC, DeSimone JM, Yeh JJ (2016) Iontophoretic device delivery for the localized treatment of pancreatic ductal adenocarcinoma. Proc Natl Acad Sci 113:2200–2205
- 7.
Kalia YN, Naik A, Garrison J, Guy RH (2004) Iontophoretic drug delivery. Adv Drug Deliv Rev 56:619–658
- 8.
Gratieri T, Kalia YN (2014) Targeted local simultaneous iontophoresis of chemotherapies for topical therapy of head and neck cancers. Int J Pharm 460:24–27
- 9.
Conroy T, Desseigne F, Ychou M, Bouché O, Guimbaud R, Bécouarn Y, Adenis A, Raoul JL, Gourgou-Bourgade S, de la Fouchardière C, Bennouna J, Bachet JB, Khemissa-Akouz F, Péré-Vergé D, Delbaldo C, Assenat E, Chauffert B, Michel P, Montoto-Grillot C, Ducreux M, Groupe Tumeurs Digestives of Unicancer, PRODIGE Intergroup (2011) FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med 364:1817–1825
- 10.
Moffitt RA, Marayati R, Flate EL, Volmar KE, Loeza SG, Hoadley KA, Rashid NU, Williams LA, Eaton SC, Chung AH, Smyla JK, Anderson JM, Kim HJ, Bentrem DJ, Talamonti MS, Iacobuzio-Donahue CA, Hollingsworth MA, Yeh JJ (2015) Virtual microdissection identifies distinct tumor- and stroma specific subtypes of pancreatic ductal adenocarcinoma. Nat Genet 47:1168–1178
- 11.
Na YS, Kim SM, Jung KA, Yang SJ, Hong YS, Ryu MH, Ro S, Cho DH, Kim JC, Jin DH, Lee JS, Kim TW (2010) Effects of the HDAC inhibitor CG2 in combination with irinotecan, 5-fluorouracil, or oxaliplatin on HCT116 colon cancer cells and xenografts. Oncol Rep 24:1509–1514
- 12.
Azrak RG, Cao S, Slocum HK, Tóth K, Durrani FA, Yin MB, Pendyala L, Zhang W, McLeod HL, Rustum YM (2004) Therapeutic synergy between irinotecan and 5-fluorouracil against human tumor xenografts. Clin Cancer Res 10:1121–1129
- 13.
Louvet C, Coudray AM, Tournigand C, Prévost S, Raymond E, de Gramont A, Chazard M, Gespach C (2000) Synergistic antitumoral activity of combined UFT, folinic acid and oxaliplatin against human colorectal HT29 cell xenografts in athymic nude mice. Anticancer Drugs 11:579–582
- 14.
Wallace BD, Roberts AB, Pollet RM, Ingle JD, Biernat KA, Pellock SJ, Venkatesh MK, Guthrie L, O'Neal SK, Robinson SJ, Dollinger M, Figueroa E, McShane SR, Cohen RD, Jin J, Frye SV, Zamboni WC, Pepe-Ranney C, Mani S, Kelly L, Redinbo MR (2015) Structure and inhibition of microbiome β-glucuronidases essential to the alleviation of cancer drug toxicity. Chem Biol 22:1238–1249
- 15.
Büchel B, Rhyn P, Schürch S, Bühr C, Amstutz U, Largiadèr CR (2013) LC–MS/MS method for simultaneous analysis of uracil, 5,6-dihydrouracil, 5-fluorouracil and 5-fluoro-5,6-dihydrouracil in human plasma for therapeutic drug monitoring and toxicity prediction in cancer patients. Biomed Chromatogr 27:7–16
- 16.
Kai MP, Keeler AW, Perry JL, Reuter KG, Luft JC, O'Neal SK, Zamboni WC, DeSimone JM (2015) Evaluation of drug loading, pharmacokinetic behavior, and toxicity of a cisplatin-containing hydrogel nanoparticle. J Control Release 204:70–77
- 17.
Hammel P, Huguet F, van Laethem JL, Goldstein D, Glimelius B, Artru P, Borbath I, Bouché O, Shannon J, André T, Mineur L, Chibaudel B, Bonnetain F, Louvet C, LAP07 Trial Group (2016) Effect of chemoradiotherapy vs chemotherapy on survival in patients with locally advanced pancreatic cancer controlled after 4 months of gemcitabine with or without erlotinib: the LAP07 randomized clinical trial. JAMA 315:1844–1853
- 18.
Heestan GM, Murphy JD, Lowy AM (2015) Approach to patients with pancreatic cancer without detectable metastases. J Clin Oncol 33:1770–1778
- 19.
Indolfi L, Ligorio M, Ting DT, Xega K, Tzafriri AR, Bersani F, Aceto N, Thapar V, Fuchs BC, Deshpande V, Baker AB, Ferrone CR, Haber DA, Langer R, Clark JW, Edelman ER (2016) A tunable delivery platform to provide local chemotherapy for pancreatic ductal adenocarcinoma. Biomaterials 93:71–82
- 20.
Yi HG, Choi YJ, Kang KS, Hong JM, Pati RG, Shim IK, Lee CM, Kim SC, Cho DW (2016) A 3D-printed local drug delivery patch for pancreatic cancer growth suppression. J Control Release 238:231–241
- 21.
Wu H, Infante JR, Keedy VL, Jones SF, Chan E, Bendell JC, Lee W, Kirschbrown WP, Zamboni BA, Ikeda S, Kodaira H, Rothenberg ML, Burris HA, Zamboni WC (2015) Factors affecting the pharmacokinetics and pharmacodynamics of PEGylated liposomal irinotecan (IHL-305) in patients with advanced solid tumors. Int J Nanomed 10:1201–1209
- 22.
Pikal MJ (2001) The role of electroosmotic flow in transdermal iontophoresis. Adv Drug Deliv Rev 46:281–305
- 23.
Leucovorin [package insert] (2012) Sagent Pharmaceuticals, Schaumburg, IL, USA
- 24.
5-Fluorouracil [package insert] (2000) APP Pharmaceuticals, Schaumburg, IL, USA
- 25.
Irinotecan [package insert] (2008) Sun Pharmaceuticals, Gujarat, India
- 26.
Oxaliplatin [package insert] (2009) Hospira, Gujarat, India
- 27.
Melisi D, Xia Q, Paradiso G, Ling J, Moccia T, Carbone C, Budillon A, Abbruzzese JL, Chiao PJ (2011) Modulation of pancreatic cancer chemoresistance by inhibition of TAK1. JNCI 103:1190–1204
- 28.
Kurata N, Fujita H, Ohuchida K, Mizumoto K, Mahawithitwong P, Sakai H, Onimaru M, Manabe T, Ohtsuka T, Tanaka M (2011) Predicting the chemosensitivity of pancreatic cancer cells by quantifying the expression levels of genes associated with the metabolism of gemcitabine and 5-fluorouracil. Int J Oncol 39:473–482
- 29.
Cui Y, Brosnan JA, Blackford A, Sur S, Hruban RH, Kinzler KW, Vogelstein B, Maitra A, Diaz LA, Iacobuzio-Donahue CA, Eshleman JR (2012) Genetically defined subsets of human pancreatic cancer demonstrate unique in vitro chemosensitivity. Clin Cancer Res 18:6519–6530
We would like to thank X. Wang, C. Santos, S. Herrera-Loeza, UNC Animal Studies Core, PDX Program, and the Tissue Procurement Facility for their contributions to this work.
University Cancer Research Fund at the University of North Carolina. J. D. B. was supported by a National Defense Science and Engineering Graduate Fellowship, UNC Medical Scientists Training Program NIGMS-2-T32-GM008719, and PhRMA Foundation Fellowship.
Ethics declarations
Conflict of interest
J. D. B., J. M. D., and J. J. Y. hold equity in the start-up company, Advanced Chemotherapy Technologies L.L.C.
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Cite this article
Byrne, J.D., Jajja, M.R.N., O'Neill, A.T. et al. Impact of formulation on the iontophoretic delivery of the FOLFIRINOX regimen for the treatment of pancreatic cancer. Cancer Chemother Pharmacol 81, 991–998 (2018). https://doi.org/10.1007/s00280-018-3570-3
Issue Date:
- Iontophoresis
- Pancreatic cancer
- Device delivery
- Chemotherapy


text:
Rosana Herrero-Martín
Rosana Herrero-Martin (Burgos, Spain, 1976 - ) holds a European Doctorate on Language Performativity and Irish Theatre from the University of Salamanca. MA in Anglo-Irish Literature and Drama, University College Dublin. She is the author of the book, The Doing of Telling on the Irish Stage: A Study of Language Performativity in Modern and Contemporary Irish Theatre (Peter Lang, 2008). She is currently Spanish Senior Lecturer at Antigua State College and University of the West Indies on the Caribbean island of Antigua. She is an active literary translator and interpreter. Her research interests converge at the intersection of the following coordinates: theatre and performative studies; comparative and postcolonial literature; Hispanic Caribbean and Indo-Caribbean theatre; Cuban ritual and religious performativity; Irish literature and theatre, as well as second-language teaching and didactic material design.


text:
Installation fails (at least on xenial) with:
The repository 'https://deb.nodesource.com/node_6.x xenial Release' does not have a Release file., W:Data from such a repository can't be authenticated and is therefore potentially dangerous to use
This bug is missing log files that will aid in diagnosing the problem. While running an Ubuntu kernel (not a mainline or third-party kernel) please enter the following command in a terminal window:
apport-collect 1743995
and then change the status of the bug to 'Confirmed'.
If, due to the nature of the issue you have encountered, you are unable to run this command, please add a comment stating that fact and change the bug status to 'Confirmed'.
This change has been made by an automated script, maintained by the Ubuntu Kernel Team.
Changed in linux (Ubuntu):
status: New → Incomplete
tags: added: artful
$ echo | mutt -a syslogs.tar.gz email@example.com
Try installing npm using aptitude:
sudo apt install aptitude
sudo ...READ MORE
A 777 permission on the directory means that everyone has access ...READ MORE
Hey @Dinesh, this isn't an error, its ...READ MORE
Please check the below-mentioned syntax and commands:
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Pamper Yourself In Scottsdale Arizona
Scottsdale, Arizona, is one of the nation's "fun capitals," and is known worldwide for its art galleries, international restaurants, hiking trails, specialty hotels, museums, canal walkway, sporting venues, and more.
Even local residents from the larger Phoneix head to Scottsdale when the weekend arrives. They, along with visitors from every part of the world, enjoy spending an evening or two among the walker-friendly shopping districts, gardens, theaters, historic landmarks and spas.
If you're headed to Scottsdale in the near future, here are a few of the local highlights to get you started on your Arizona adventure:
Things To Do
The Old Town area is a favorite due to its many fine dining spots, nightclubs, art galleries and local historical sites. Frank Lloyd Wright's second home, Taliesin West, is just a short drive and is open to tourists throughout the year.
The enclave, which houses a world-renowned architecture school and sculpture garden, features dozens of buildings that Mr. Wright designed and built with his young team of artisans in the 1930s.
The McCormick-Stillman Railroad Park includes a unique collection of classic train cars, an old depot, and a railroad museum that is nationally known for its fine specimens of a bygone era. Not far away is Pinnacle Peak Park, one of the nation's largest and most scenic desert parkland area that is a local favorite for weekend picnics and trail walks.
The city of Scottsdale caters to walkers and those who don't want to drive. You can use the convenient bus system to get just about anywhere in the city. There's also a small bus-van service call "The Scottsdale Trolley" that runs continuously and covers most of the major shopping areas with rides every few minutes.
Like many other US towns, there are multiple choices for those who want to take electric scooters or wheeled devices, all of which are rentable by the hour.If you don't bring your own bicycle and want to ride one, there are several local Scottsdale bike rental shops that offer a wide range of models at reasonable prices. A bike trip through Old Town can be one of the best ways to see that part of town because of all the nooks and crannies that aren't accessible by car.
Sporting Fun
For sports enthusiasts, the Salt River Fields at Talking Stick and Scottsdale Stadium are two places to see Major League Baseball spring training games. The Ice Den is the best local rink in the area; it is not only huge, but it also offers classes and lessons for beginners.
For walkers and runners, there are numerous trails in and through Scottsdale, and the hike to the top of Camelback Mountain is a hugely popular activity for those who want the best possible view of the city.
The Andaz Scottsdale Resort & Bungalows is a popular hotel choice for visitors and locals who want picturesque scenery of Camelback Mountain, a top-rated spa, comfortable bungalows and eclectic dining choices.
Anyone looking for a Scottsdale resort and spa experience will appreciate the Andaz Scottsdale Resort location too. It's situated in the middle of all the action that has made the city a worldwide destination.


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It's happening...
Finally here is the cure worse than the disease, as Trump said, a Venezuelan hell hole where we start preying on each other to keep from starving? I've been waiting for this shoe to drop.
Fortunately we have the Greatest Generation that showed us what to do. So let's get busy. In the cities a new movement has been slowly taking hold and the time is ripe for it to blast off across America. City governments need to pass emergency ordinances designating park space for food growing, with the space organized by designated local committees.
This corona thing, as awful as it is, is an opportunity for a long overdue change in the fragile supply chain which makes large parts of our population hostage to the social chaos which can arise from the mismanagement of the bankers' debt and fiat money economy. No longer are there blank stares or smug smiles when talking prepping, self-sufficiency, and food growing.
People are away from their Monday Night Sports fixes and they are paying attention. They may never be paying this close attention again.
Coronavirus may cause some food shortages, warns government task force
I for one cannot sit still as I watch a freight train coming at me. MORE>>> https://hubpages.com/politics/Food-S...ests-Push?done
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Babysitter Bunga is a book inspired by The Lion Guard.[1]
Author's Description
The Lion Guard is stunned when Bunga becomes the go-to babysitter for all the Pride Lands parents. His babysitting style is highly unorthodox, but when his young charges are threatened, they use all the fun things Babysitter Bunga taught them to fight back against the jackals - and win!
The Lion Guard are out on patrol when they notice Reirei's pack in the Pride Lands attacking a zebra herd. The Guard race to save the zebras, but Ono notices that two jackal pups, Dogo, and his sister Kijana are separating a baby zebra from the rest of the herd.
While the rest of the Guard attack the adults, Ono and Bunga race over to assist Hamu. They take down Dogo's sister, but Dogo pounces on Hamu. Bunga cries out for Hamu to kick and he obeys, sending the other jackal flying. Bunga commends the young zebra for his success.
After chasing all of the jackals back into the Outlands, Hamu's mother, Muhimu, is still nervous after the whole ordeal. Beshte suggests that she takes some time out for herself, but Muhimu asks what she would do with her son. She turns to see Hamu playing happily with Bunga, and asks if he can stay with him. Bunga doesn't see why not and decides to take him back to Hakuna Matata Falls.
Muhimu heads to the Watering Hole to relax, alongside some other mothers. Her friend Twiga calls out for her daughter to avoid the porcupine in case she gets hurt, but then notices Hamu's absence. After asking where he is, Muhimu informs her that Bunga is babysitting for her, which makes the other parents wonder if he could do the same for them.
With Bunga and Hamu enjoying themselves at the falls, the other mothers show up and ask Bunga if he can take care of their children as well. Bunga is excited about the increase in kids since it means the noise and splashes will also increase, and agrees.
Bunga is then left with Young Rhino, a Little Monkey, a Young Serval and Juhudi in addition to Hamu. When they ask him what to do, he replies that they should teke, ruka and teleza.
He demonstrates "Teke" with Hamu, instructing him to kick while Twiga's daughter watches. He demonstrates "Ruka" with the monkey, instructing the monkey to jump while the serval watches. And finally, he demonstrates "Teleza" with Young Rhino, telling him to slide.
Meanwhile, over in the Outlands, Reirei's Pack are practicing their hunting skills. When satisfied with their work, Reirei praises her children and states that it's time to return to the Pride Lands.
Back at Hakuna Matata Falls, the kids are enjoying themselves so much that they fail to see the jackals sneaking up on them. They leap out of the bushes and approach the children. Bunga exclaims "Teke" to them, and the kids kick with all their strength, sending the jackals away.
Bunga then notices Goigoi about to pounce on the monkey. He calls "Teleza" to him, and the monkey slides on his belly across the grass. Goigoi tries the same but crashes into a pile of rocks.
While Bunga tries to defend himself against Reirei, he sees Hamu being chased down. He warns the zebra, but the zebra replies that he knows what to do. He leaps onto a teeter-totter rock and, when Dogo hops on the other end, he leaps off. Hamu cries "Ruka" to Young Rhino, who jumps onto Hamu's end of the rock, launching Dogo into the air. Hamu happily exclaims that it's how they do it in Hakuna Matata Falls.
Just then, Beshte, Fuli, Ono and Kion arrive. Kion asks if he and Hamu are okay, and Bunga proudly informs him that his brave kids managed to defeat the jackals. Hamu then adds that they're brave like Bunga. Fuli wonders where all the other kids came from, and Bunga is only able to assume that the word spread about how much of an "un-bungalievable" babysitter he is.
With Young Rhino sitting on her, Reirei calls to Kion and orders him to look at what the "horrible little kids" have done to them, asking for his help. Kion agrees to assist her, provided that she leaves the Pride Lands for good this time. She agrees, and the jackals leave, without looking back.
A little later, the parents come to pick up their kids. Bunga informs them of how they managed to fend for themselves against the jackals, and Hamu explains how Bunga taught them about Teke, Ruka, Teleza. Muhimu is impressed that Bunga taught them how to defend themselves and labels him as the best babysitter ever.
Soon, the kids have to return to their parents. They gather around Bunga and say their goodbyes. Fuli admits that Bunga is really good with kids. The honey badger shrugs, asking her to call him "Babysitter Bunga".
Differences From The Episode
- Goigoi distracts the Lion Guard and falls in a hole he never attacked the kids
- Fuli doesn't admit that Bunga is a good babysitter Muhimu does instead
- This is the first and currently only book that does not feature Kion on the cover of the US released book.
- This is the first book to be released before the episode.
- Bunga's Mark of the Guard is on the underside of his arm on the cover of the book.


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Hunt Ortmann is one of the foremost authorities on California construction law, contracts, dispute resolution and litigation offering additional legal services in the areas of business and commercial law, employment matters and labor law compliance, real estate, insurance and suretyship.
Presented by Wahid Guirguis, Esq.
Shareholder, Hunt Ortmann Palffy Nieves Darling & Mah, Inc.


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This month I have been lucky enough to have my first tutorial published by Bead and Jewellery Magazine. It is in issue 76, the romance and passion-themed one for Valentines Day. This is a great magazine, perfect for seed bead beginners who just want to learn more.
The tutorial is a basic introduction to the technique of hand stamping aluminium. I have previously blogged about my stamping journey here, and the evolution of my polishing. There are lots of suppliers out there for stamping tools, I prefer Little Freckle who has a great range. I tend to get my blanks from Metal Stamping Blanks, always reliable and great quality aluminium blanks.
I created 3 pendant necklaces for this tutorial. If you like them, make sure you buy the magazine to learn how to create them.


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I got a seminar topic named Forecasting risk from cross sectional moments? Could at least someone tell me what should I write about and if there is any paper that I could read. Thank you very much in advance.
Active 4 years, 10 months ago
Viewed 79 times
1$\begingroup$ I am not sure what "cross sectional moment mean"? Are you sure it is not "second central moment"? $\endgroup$ – Robert Szóstakowski Sep 14 '15 at 19:35
$\begingroup$ I haven't the faintest either, this topic is actually the top hit for '"Cross-sectional moments"' on Google in incognito mode for me. @user17539, can you please clarify? $\endgroup$ – Bob Jansen♦ Sep 14 '15 at 20:34
$\begingroup$ Look up "cross sectional standard deviation" or "cross sectional dispersion". It is a measure of how the population of stocks stocks did on a particular day. (all stocks up or all stocks down => dispersion of zero. $\endgroup$ – noob2 Sep 17 '15 at 19:54


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Sessions: Two
Fee: $42
Date/Time: Mon, April 29 & May 6 from 10:30 – 1:30
Instructor: Carol Kinsley
Description: Back by Popular Demand! We had such a fun time making umbrellas we're doing it again! There are kits for the umbrellas, and I will get them for you. (Aprrox. $32). The first class you will need your sewing machine and the second class will be finishing it with the hand sewing. There is a shelf of digital fabric at TIS that would be spectacular for an umbrella!


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Screen Time: Our best & worst TV finales
October 14, 2019
All good things must come to an end. This includes long-running television series, though sometimes they may not end the way we would like them to. In this week's edition of Screen Time, TPN staffers share what they believe are some of the best and worst television finales.
Opinion | "Game of Thrones" Characters as 2020 Presidential Candidates
By Devi Ruia, Staff Columnist
April 18, 2019
With "Game of Thrones" returning this past Sunday for its final season, here are the characters that most closely align with 2020 Presidential Candidates.
Winter is here: Bar of Thrones opens doors in Market Square
By Delilah Bourque, Senior Staff Writer
April 10, 2019
Winter has come to Pittsburgh's Market Square. While the weather has been warming up, Bar of Thrones, a Game of Thrones themed pop-up bar, has opened downtown. The bar serves Game of Thrones-themed cocktails, along with beer, wine and certain food offerings.
Game of Thrones awkwardly rushes plot in season seven finale
By Luke Stambaugh / Staff Writer
August 29, 2017
Watching the "Game of Thrones" season seven finale was as entertaining as it was frustrating. The creators of HBO's fantasy and action juggernaut provided six seasons of carefully crafted dynamic characters and complex interwoven storylines. But the finale of season seven was unfortunately rushed...
'Shall we begin?': Dragons, the undead and murderous mortals take their final places in 'Game Of Thrones' premiere
By Matt Maielli / Contributing Editor
July 19, 2017
In the "Game of Thrones" season seven premiere, "Dragonstone," the remaining pieces of the Great Game finally move into their places on the board. A large part of prestige television — which viewing audiences are drowning in lately — is waiting. That is definitely true of HBO's "Game of Thrones" and also true of S...
'Game of Thrones'-themed beer provides fiery spice
By Stephanie Roman / Staff Writer
April 17, 2014
Daenerys Targaryen, the only surviving child of King Aerys II, deposed by King Robert Baratheon and competitor for the Iron Throne of Westeros, once said, "I will take what is mine with fire and blood." Such is the name of Ommegang Brewery of Cooperstown, N.Y., and HBO's newest beer in the "Ga...
'Game of Thrones' picks up pieces from tragic third season
By Allison Latzko / Staff Writer
April 7, 2014
"Game of Thrones"Episode: "Two Swords"Grade: BIt's hard to come up with something more shocking and horrifying than the "Red Wedding," which left viewers with a huge game-changing scene for hit HBO original series Game of Thrones. The debut of the show's fourth season slowed down the pace a bi...


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Experts share the latest on equipment maintenance
For waste management fleets facing heavy workloads and tight schedules, ensuring uptime and reliability from their trucks and equipment is paramount to success. That's why maintenance can be the key to improving your fleet's overall performance. Download this free eBook to learn how to optimize your maintenance plane.
Learn how to maximize reliability in hydraulic systems
Find out how to prevent hose failures
See the secrets to keeping trucks running all winter
Learn about simplifying oil cleanliness specs


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Damaged neck disc can be a great problem for anybody. If you have neck disc herniated, you may feel severe pain in your shoulder blades, pain in neck while moving it in various directions, or bending it. Sometimes you may also feel stiffness in neck muscles also known as muscle spasm.
In some cases people feel numbness or a tingling feeling in their arms. Sleeping in awkward position can also cause herniated neck disc problem. Due to herniated disc, you may also feel weakness in your arms, biceps and handgrip. It should be taken seriously and for those that stay in Singapore, visiting Specialist Pain International Clinic can be a great advantage.


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Sweet and tangy dip can be enjoyed with any type of snack or wafers....
1 Red bell pepper
1 dry red chilli, soaked in water
1 tbsp garlic
3 tbsp onion, roughly chopped
1 tomato, roughly chopped
Salt to taste
1 tbsp olive oil
Vegetable stock for consistency, if required
- Sauté the onion, garlic and tomato on medium heat, for 5 minutes or until soft.
- Grill bellpepper and roast to all sides evenly. Place roasted bellpepper in cold water for 5 min.
- When cool enough to handle, remove off the roasted skin, cut the peppers in quarters and remove seeds and membranes.
- Blend all ingredients together. If the sauce is too thick add stock, 1 tbsp at a time to make a smooth, but not thin, sauce.
- Serve with snacks or wafers.


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Ministry of Finance and Mass Media has called applications from journalists for 'AsiDisi Media Scholarship Program - 2017', which will provide financial assistance for the training courses of journalists.
Journalists serving in recognized electronic and print institutions island-wide on full time or part time basis, freelance journalists, provincial journalists and web journalists, who have completed a three year service period and between 18-55 years of age are eligible to apply for the scholarship.
Selected journalists will be granted financial assistance for their training courses directly linked to the field of media to a maximum of Rs. 100, 000. Applicants should not be benefitted from the AsiDisi Scholarship Program earlier.
Applications should be sent through registered post to Director (Media), Ministry of Finance and Mass Media, No 163, Kirulapone Avenue, Polhengoda, Colombo 05 before 31st July 2017.
For further details contact 011 - 2, 513 645, 011 - 2 513 459 and 011 - 2 513 460 and log on to www.media.gov.lk for the application.


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Things looking bleak?
When milestone days approach, a holiday, a birthday or deathday, do your emotions tumble downhill as you struggle with lonely, depressing efforts to hold back your feelings? Is the one you really want with someone else, or did he or she pass away, yet you hunger and yearn for whom is missing? Do you have to push away painful memories just to get through the day and that takes all your concentration and energy? The pain of heartbreak can be acute and overwhelming. Your grief keeps you focused on the pain when you think about them. Maybe after fifty years you only remember the day someone died or your first love's face as he left you. The grief blocks all the good memories that lie beneath waiting.
Would you like to try a quick fix for an enduring heartache?
You have memories of these people that are yours to enjoy, too. If you can just get past the grief, even temporarily, you might recapture lost moments of joy.
Take tonight to be alone and set the stage for memories of someone who was once precious, but is now missing. Light some candles, get out the worn photos, drop the fake smile from your face….finally, and allow yourself to really feel the pain. Step into the murky water of your tears and despair and wail and cry, for say, ten minutes. Then, take the next ten minutes to crank up some rhythmic music and express the pain physically. Boldly and wildly move your body in an expression of your hurt. Next, gradually change the dance to a joyful or silly one, like the chicken dance. The physical efforts release brain chemicals. Hopefully, no one is watching this cathartic gig but if someone is, explain that you dance for your health.
Grief held inside is poison. The act of grieving is about releasing the toxic thoughts and physical ramifications of those thoughts. Faking it, smiling when you could split apart in pain or pretending you do not care is not fooling your organs. Get the pent up rage, despair, guilt or envy out of you. Just talking about it or ignoring it will not release grief as well as the Brokenheart Stomp. The change from a grieving movement to a happier movement will send a powerful signal to the mind that you are trying to recover from grief.
Purging grief is a detox cleanse that allows you to recover joy and balance to your mind and gut. You NEVER have to stop feeling love and longing for what you miss, but you need to periodically fall back deeply into your sadness, feel terrible and then release it quickly just like a cramp in your foot. When the pain begins to build up, try shaking it out and then laugh loudly long before you sincerely feel happy. Our bodies respond to the emotion we act out, so act out a joyful dance.
Loving someone – even if it does not last – can become a source of experience and strength to treasure, if you learn to release the grief regularly. Grief can last years, but your nervous system needs a break frequently. The Heartbreak Stomp may shorten the pain by grieving the feelings out just a bit while you laugh at your antics. Take this opportunity to remember the good and bask for a bit in positive memories of having loved someone dearly. Eventually, the pain will go and the good memories will heal your heart and last forever.
Dr. Molly Barrow holds a Ph.D. in clinical psychology and is the author of the new book, ?Matchlines: A Revolutionary New Way of Looking at Relationships and Making the Right Choices in Love.? She is an authority on relationship and psychological topics, a member of the American Psychological Association and a licensed mental health counselor. Dr. Molly has appeared as an expert on NBC, PBS, KTLA, and in O Magazine, Psychology Today, Newsday, MSN.com, Match.com, Women?s Health and Women?s World. Please visit: www.askdrmolly.com, www.DrMollyBarrow.com
Article Source: http://EzineArticles.com/?expert=Molly_Barrow


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Atlus Releasing Trine 2, Rock Of Ages For Digital Platforms
June 18, 2010 6:00 AM | Eric Caoili
As part of its E3 showing this year, Atlus debuted two intriguing indie titles it intends to release through digital distribution platforms: Frozenbyte's Trine 2 and ACE Team's Rock of Ages.
Trine 2, naturally, is a sequel to last year's well-received high-fantasy, physics-based action platformer for PC/PSN. This follow-up will include "more action, more puzzles, and the introduction of online support" for its three-person, co-op multiplayer mode. Expects this to release on so-far unspecified digital distribution platforms next spring.
Also coming next spring is a new and original title from ACE Team, the Chilean studio behind acclaimed first-person shooter/brawler Zeno Clash. Rock Of Ages (trailer after the break) is a completely different experience from ACE's debut title, combining strategy with rock-rolling in over two dozen stages.
In Rock Of Ages two warring castles take turns sending giant boulders across an uneven, narrow pathway in order to take down their opponent's towers. In between the rock-rolling, they build defenses on that pathway. Just as awesome as the concept, each stage is modeled after a different period of classical art, featuring art styles and music from that era.


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Keyblade reshapes the concept of comfort in the sports eyewear combining our unique Vent Controller System to efficiently manage airflow, the enhanced Vertical Power Flow ventilation system with its nicely detailed exhaust ports scientifically integrated within the upper chassis, the adjustable temple tips and nose-pads. The Keyblade slim design allows a perfect fit for women and smaller heads and is fully RX able.
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Great product
I love the sunglasses. They don't fog like all my previous glasses did, the photochromic property is especially nice since on many long rides I encounter varied lighting conditions. Thanks!
Good product & reasonable prices


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Madison Square Garden Resident DJ, Tiff McFierce takes us down memory lane as she provides hits that totally made us fall completely in love. The formula of meaningful songs that still had structure and catchy bridges, Tiff reminds music lovers of what has been missed for some time now.
Tiff says:
Happy Valentine's Day my lovelies! As some of you know, I released a McFierce, vibe-y mix for this 2017 VDay a couple of weeks ago for you all. Whether you have a bad or you're just buying your moms some chocolates, rock out with me to the sounds of great song structure and ACTUAL bridges. Remember those? Yes, I took it to the bridge for you with this mix. Nothing but love, all the fierce feels and swaying with head bops. NAYYYHOOOOOOOO! Get your harmonies and ad libs on. Have a sweet Vday!
XOXO, Tiff
She also said:
Vibes on vibes on vibes ONLY, because If the love don't feel like 90's r&b…
I grew up when songs still had bridges & fly song structure- so I aint cutting sh*t short! 🙂 Enjoy loves! Happy Valentine's Day!
P.s-Thank you to every boy in middle school, high school & college that made mixtapes/cd's- this is for you, LOL!
Get into the spirit of Love above.


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YOUNG dancers have been working with professional performers ahead of a tour of local venues.
Phoenix Dance Theatre spent four days working with the youngsters at Brooklyn Youth Centre in Norton to create a short piece to be performed ahead of their critically acclaimed show REfined.
The project 'Create Tour' was launched in 2013, by Rural Arts, to give young people the chance to tour alongside performers while they work in the area, providing young people with valuable, professional experience.
Chloe Hampson, Rural Arts ON Tour coordinator, said it was an exciting opportunity for youngsters to experience dancing in front of an audience.
"The project also gives young people in rural areas the chance to work with professional performers," she added.
"During the workshop we have had a mix of some who have danced before and others who have never taken part in a dance performance."
Leeds based Phoenix Dance Theatre is performing at several venues in as part of Rural Arts spring ON Tour line up.
The show is a mixed programme with solos, duets and more and highlights their most popular pieces from the last five years.
As well as a curtain raiser from local young people, REfined is followed with a Q&A.
REfined will be at the Milton Rooms in Malton on Friday, April 25 and Kirkbymoorside Memorial Hall on April, 26.
Tickets and more information is available online at www.ruralarts.org
All projects are thanks to Rural Arts funders Arts Council England, Ryedale Council and North Yorkshire Youth.