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Some people — a confusing group of humans who insist three-hour-long movies shouldn't be made on the subject of male biceps — have declared Bahubali:The Conclusion a perfect excuse to practice eye-rolling. They have been accused of a terrifying crime called common sense. And have been pulled up for not showing the basic human decency of breaking into 'Meri desh ki dharti, sona ugle, ugle hire moti' at the mere sight of Prabhas tackling elephants like they are hair dryers. Is it fair that you call yourselves Cumberbitches and Potterheads but don't want to put #BahuBro or #Baliber as your Facebook status? The nation wants you to know: no, not possible, never, #NaNaNaNaNaRe.
An extremely unnecessary human affliction called rationality is asking you to question this accusation. First, why does anyone who dislikes Bahubali get deported to team Troy-300-Hercules aka White-Men-In-Leather-Minis? How does a Bahubali fan arrive to the conclusion that a person who dislikes his favourite movie must automatically love Harry Potter and Lord Of The Rings and The Hobbit? It's like concluding you must love Coca Cola because you don't like masala papad. And that's a crime.
Assuming you like the Harry Potters and Gollums of the world, do you have a moral duty to express appreciation for Amarendra Bahubali and Ballal Deva? Let's examine this bit.
Is Bahubali: The Conclusion an act of charity? If you have watched the film in a multiplex, you have shelled out no less than 200 rupees to watch it. A sum of money which, hopefully, you earned yourself by some legal means. It's a commercial transaction — your having watched the film and the makers of the product, the film in this case, profiting from your spending on it. Are you allowed to say you didn't like it one bit? Looks like you are. Are you an unpatriotic twat for doing that? Well, then you are that as well if you have complained about potholes on roads, a badly-made aloo paratha, jokes in Sajid Khan movies, the IRCTC's website, Delhi's summer and Mumbai's traffic. They're as 'Indian' as Bahubali. The criteria of appreciating a film can't be that it is 'Indian'.
Rough estimates of floating around the Internet peg Bahubali: The Conclusion's budget at Rs 250 crores. Dharma Productions — one of the biggest Bollywood production houses — is distributing the film. SS Rajamouli has made at least 8 films before the Bahubali series. So really, Bahubali need not be treated like a child learning cursive writing or your grandfather trying to make a GIF for the first time. It's difficult to understand why no one is allowed to dislike the films because "at least they are trying to do something like LOTR", as the outraged are saying.
Bahubali: The Conclusion follows the good versus evil format of most movies of the fantasy genre. It's symbolism is extensively reminiscent of Hindu myths and fables and it is a fairly unmasked celebration of Lord Shiva. It also follows the central theme of most mainstream Indian movies — the hero worship of an all-powerful, stereotypically masculine, male figure. In Bahubali, the hero is not only an ardent worshipper of Lord Shiva, he is ready to lay down his life for his mother — another successful trope of melodrama in Indian popular cinema. Put together, it isn't difficult to see how Bahubali has managed to stoke this fervent, devotion-like sentiment among Indian audiences. Now, none of this is completely problematic in the world of fictional film-making as long as the movie is well-scripted and executed. But that's exactly what Bahubali: The Conclusion isn't.
Bahubali is a film which treats women like second-class citizens in its universe. The first film had the hero do really creepy stuff on a sleeping woman who possibly didn't go off to sleep expecting some dude paint on her hands. And he doesn't stop at that. Despite the woman's protests, he puts colour on her mouth, yanks open her braid, and nearly strips her, apparently to bring out her femininity. The second part associates courage and masculinity with cutting up tree trunks, human beings and pillars. Bahubali:The Conclusion pays a token nod to "strong, independent women" by creating the character of Devsena, a warrior princess. But, at the end of the day, she first needs to get saved by her paramour and then has to be rescued by her son. If you have found in Bahubali some great treatise on women's empowerment, thank you — us women will settle for online sales in the name of 'empowerment' instead. The actors in Bahubali declare they are Kshatriyas more number of times Donald Trump has whined about China. And then make themselves sound like one can't do without them. Let's call it the Aadhaar Card complex.
Now, what can make anyone un-see all of the above? Nothing.
Also on HuffPost


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Hindenberg Women's Black/Gold Leather Duchess Watch
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While you're in Charlotte County, you'll see a lot of the ocean. Whether you're on an island off the coast or even driving by it on the highway or a back road, you'll always be able to see it.
But the lakes in our region have just as much to offer when it comes to beautiful views, fun activities, and fishing. Many locals go to the lakes to cool off in the summer heat, and countless people come to see what they can catch in the lakes. Kayaking, paddle boarding, and boating are some of the most popular lake activities, and with so many different lakes, the places and possibilities are endless.
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This weekend I had the pleasure of stopping by one of my favourite shops in the world: Becnicks Wonder Emporium
Since my last visit to Chester the vintage shop has moved locations – and is just as amazing
What's so good about this place?
The variety and quality of the clothing, furniture, home accessories and other collectibles is really staggering – at every corner there's an object of desire (I was very controlled)
The staff are super friendly and happy to help – or just have a chat
And they serve tea and homemade cake (every shop should)
Definitely worth a visit
Discovered any amazing shops recently? Do share!


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Your home is where you have built, or plan to build, a life with your family. It is where crazy and emotional memories are made. It is also an extension of the person you are and also shows off your personal style and taste. This is why all homeowners take pride in their houses and make sure that it always looks its best. Apart from offering protection, your home is also an asset. This is why you need to make sure that it is always well-maintained, even if it means spending a little extra money.
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|Barrett's Support Forum :Barrett's Support Forum :Support Forum
|Topic: Screening
Joined: 06 Aug 2011
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Posts: 36
| Topic: Screening
Posted: 11 Nov 2011 at 1:20am
This was posted on Medscape during the week. I think it is advocating less ongoing screening for Barretts patients. What do others think?
This is the cover paragraph with their special report. This article addresses whether there is too much screening--at least, I think that what it is discussing. Again, this is Medscape's material but they indicated it could be shared, printed, emailed, so here it is.
Medscape Special Report November 9, 2011
Barrett Esophagus
From Medscape Gastroenterology
Expert Commentary and Insight
Barrett Esophagus: Are We Screening Too Often?
Barrett Esophagus and Cancer: Not A Clear Link
Risk for Progression to Cancer in Barrett Esophagus
Esophageal Cancer: New Ideas About Risk and Management
An Expert Interview With Jaffer A. Ajani, MD
Recent News
Cancer Risk in Barrett Esophagus Lower Than Expected
Barrett Esophagus Poses Less Cancer Risk Than Thought
Guidelines for Your Practice
Screening for Barrett Esophagus
Want More Information on Barrett Esophagus? Bookmark the Barrett Esophagus Center for the latest news and perspectives.
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From Medscape Gastroenterology > Johnson on Gastroenterology
Barrett Esophagus: Are We Screening Too Often?
David A. Johnson, MD
Authors and Disclosures
Posted: 11/04/2011
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Hello. I am Dr. David Johnson, Professor of Medicine and Chief of Gastroenterology at Eastern Virginia Medical School.
Surveillance and diagnosis are part of the mainstay of evaluation for Barrett's esophagus (BE) in patients with reflux disease. This has been predicated on knowing that BE is a precancerous condition associated with progression to cancer at an estimated incidence of 0.4%-0.5% per year, and to high-grade dysplasia at 0.9% per year. The incidence that we quote to patients is 1.5% yearly progression to high-grade dysplasia cancer.
Those studies were done some time ago, and 2 new, very large epidemiologic studies are changing the waterfront of BE. One was published in the Journal of the National Cancer Institute [1] in July; this study came from Ireland. It was a very large database, including all patients with BE, capturing data from more than 8000 patients. The mean duration of follow-up was 7 years (range: 1-20 years). The de novo progression to cancer from BE (excluding incident cancers) at 1 year was 0.13%. This incidence is very low and very different from 0.4%-0.5% per year, which had estimated the risk to be 30-40 times that of the general population. The risk is now down to 10-11 times the risk in the general population.
The most recent study, published in The New England Journal of Medicine [2] in October, shows essentially the same information, this time coming from a study in Denmark that included all patients with BE, and excluded cancer found within the first year after diagnosis. The mean follow-up was 6 years, and the rate of progression to cancer was 0.12% per year. Progression to cancer was 3 times more common in men than women. The risk in women was inordinately low.
Let me put this in perspective for you. If you look at cost modeling studies that have been done in the past (one that comes to mind is from 2003 in the Annals of Internal Medicine [3]) they found that screening or surveillance of BE was effective from a cost standpoint, at 5-year intervals if the incident cancer risk was ≥ 1.9% per year. At 1.9%, we are talking about 4 times the rates that are being reported now. The incident rate is considerably lower than 0.1%-0.13%, the rate at which it was cost-effective to screen at 5-year intervals. The current guidelines recommend 3-year follow-up for BE. This raises the question: is it cost-effective at the present time, when, because of dollar restrictions we are tossing out things like Pap smears and prostate-specific antigen tests? Surveillance in BE is certainly now subject to cost evaluation.
Throw in the most recent study that comes from a Dr. Wani and colleagues,[4] a 5-site multicenter study that looked at the progression from low-grade dysplasia to cancer. Data were analyzed for 210 patients, and specimens were reviewed by centralized pathologists. The progression rate from low-grade dysplasia to esophageal adenocarcinoma (with a follow-up of 6 years) was 0.44% per year. In progression to cancer risk, this group did not differ from patients who had no low-grade dysplasia at study entry. The study also reiterated that there is terrible concordance for agreement on low-grade dysplasia. The kappa value was 0.14, which indicates poor agreement. Intra-observer variability was very high. This study raises red flags about the paradigm of 6-month evaluations for patients with low-grade dysplasia.
No cancers were evident in the low-grade dysplasia patients within 2 years of the diagnosis of low-grade dysplasia, so it also raises the question, could we potentially lengthen out the surveillance of low-grade dysplasia patients to longer intervals? We return to the bottom line. In the present day, no data suggest that patients with BE die at a higher rate than patients without BE. No data say that patients with BE under surveillance die at a lower rate than patients without surveillance. Even for esophageal adenocarcinomas, the risk for death doesn't seem to be higher in patients with BE under surveillance strategies.
The take-home message is that we need to re-evaluate the evaluation of risk in BE, and guideline committees need to incorporate these data, recognizing that these data are all European, and the biopsy protocols are different in Europe. The definition of intestinal dysplasia is not requisite for the diagnosis of BE in Europe as it is in the United States. These data raise a number of important questions about the relative risk for patients with BE. Do they need surveillance if they don't have dysplasia? Do patients with dysplasia need surveillance at lengthened intervals?
These findings suggest that we should not be ablating patients with low-grade dysplasia or metaplasia outside of research protocols. Certainly in clinical practice, I don't think that should be the standard of care, nor would it be justifiable in the present day based on the cost evaluation and the relative risks for these patients.
There is a lot on the plate for discussion. BE guidelines committees should convene in a more rapid fashion and reassess the relative risk, and provide guidance so we can achieve cost-effective medicine for our patients with BE.
So, let's pause, take a step back, and look at BE with a lot less concern than we used to. There is no question that BE is a precancerous condition and that it is associated with adenocarcinoma of the esophagus. As the biologic behavior of BE has become better understood, the relative clinical significance has dwindled. In your next conversation with your patients with BE, put this into perspective and evaluate the strategies for surveillance. Hopefully, the guidelines will also provide us with some meaningful changes in the not-too-distant future.
I'm Dr. David Johnson. Thanks again for listening.
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Barrett Esophagus and Barrett Ulcer
Gastroesophageal Reflux Disease
Noncolorectal Gastrointestinal Cancer News & Perspectives
GERD News & Perspectives
Barrett's Esophagus News & Perspectives
Medscape Gastroenterology © 2011 WebMD, LLC
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|Posted: 11 Nov 2011 at 9:23am
Hi again Danielle,
We discussed the NEJM report of the Denmark study cited in this article a few weeks ago.
The worrying aspect is that it will probably lead to recommendations to increase the period between surveillance scopes. It will save NHS a lot of money. But will it increase anxiety in patients? After all, if the risk of developing cancer is only one in 200 per year, how do we know we're not the one in 200?
A study using BOC's UKBOR data has revealed that those with rhesus negative blood type are at greater risk than those with rhesus positive. So it may be that those of us who are rhesus positive will have less frequent screening as a compromise?
The other worrying aspect of this report is "These findings suggest that we should not be ablating patients with low-grade dysplasia." ie. HALO will be restricted to HGD even more than presently - instead of moving towards the possibility of HALO for all.
The concern is, those who make the decisions on these issues may be guided more by financial considerations than conideration for patient anxiety.
Edited by chrisrob - 11 Nov 2011 at 9:25am
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|Posted: 11 Nov 2011 at 2:30pm
D and C
ASK the doctor IF he OR his kids had BE would he ablate ? I DID !!!!!!!
I've been saying this all along " It's all about the MONEY "... I got new ins. on 9/1 and HALO on 9/5 and was worried BECAUSE you never know what the bill will be (sell my car)... Well by now I THINK I have all the bills BUT will post if I'm wrong .
Almost the same price with my ins. as a EGD.. .Thats means EGD with Sedition then Halo 90 ...
(USA)...Cheap HGD Jeff
Edited by jcombs99 - 11 Nov 2011 at 2:41pm
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|Posted: 11 Nov 2011 at 6:47pm
I know I've said it before but as one of the very small percentage who has gone on to develop cancer, screening has literally saved my life. If I had nlt been screened or they had left it more than 6 months I would not be here to tell the tale, and I am a low risk woman and a young one and one who doesn't smoke or drink.
For me I'm glad screening saved my life.
I work at the hospital where I received my treatment and I was horrified last week to see they are cutting back on screening. Isn't one life saved worth it?
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|Posted: 11 Nov 2011 at 10:55pm
Thats my main worry, that the financial restrictions being put into place, will completely change our chances of having the correct procedure........I am two thirds of the time between scans, and cant help wondering if I should pay to have another
opinion rather than wait for another 6 months, to know whats going on inside!! But I know the consultant I am under has a real attitude to anyone having private treatment................and where i live there is no other way of having another opinion...............living in an isolated part of Scotland.
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|Posted: 12 Nov 2011 at 6:23pm
You always have to look at the cost of it and if you think it's worth it ..If you just have barretts I wouldn't do it BUT make sure it's 6 months!!! Maybe next time TRAVEL and get one at a year and let the NHS do at 2 years and DON"T tell them thats all .
I just found out Meditcare which EVERYONE is on at 65 wants to limit your hospital stay to 10 to 25 days a YEAR depending on the state you live in .They want to insure everyone with POOR health care ...
Take Care
Edited by jcombs99 - 12 Nov 2011 at 6:25pm
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|Posted: 12 Nov 2011 at 7:17pm
I am just a layman, but so far as I am aware, the treatment and monitoring in the NHS is dictated by NICE, which basically lays down what you can and can't have. If NICE say you can have it, I think that's it. If there is someone on the forum who understand how treatment is approved, please put us to rights.
If NICE do decide to decrease the monitoring, it will have to justify it based on good evidence. They will find it hard because the stats on oesophageal cancer are not great. I understand that there are critics of monitoring, who say it holds no guarantee of detection and some cancers just come out of the blue. There's a lot of arguments out there, new studies etc which will all be considered.
Personally, and as a total panicker, I think that I will choose to pay for a private gastroscopy at a cost of £1200 inbetween NHS scopes, so it works out £600 p.a. Damn annoying - so its goodbye smartphone, big telly and all other silly luxuries. Well - the odd guitar may slip through the net ....
55yo, diagnosed 2011 at 5cm Barrett's, 3cm as at 2013 (?), so far non-D
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|Posted: 12 Nov 2011 at 11:33pm
Thanks for your messages..............great to know there is such support out there...........living in an isolated part of the world has its drawbacks, and my GP tends to ask me what would I like to do??!! Not a lot of help really when I am having one of my panics about cancer, which happens every time I lose another friend to the disease!! My daughter lost a university friend two days ago, who was 40 ...................no justice in the world at all!!
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|Posted: 05 Jun 2019 at 9:31pm
Hi Jeff,
Im the mother of a 19 years old daughter with 1 cm of segment of Barrett no displasic! I would like to eradicate it and my daughter too and not to wait until is progressed!! Also she doesnt want to take PPI all her life! So l understand what do you said!
We are living in USA ( Miami) if by any chance you know a good surgeon to eradicate it will be amazing! She had also a small hernia ( around 3 cm) !
Thank you so much for your understanding and help !
Lydia( yaya)
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To compare postoperative outcomes of 27-gauge (G) and 25-G vitrectomy conducted as day surgery for proliferative diabetic retinopathy (PDR).
One hundred eighty-five consecutive PDR patients (185 eyes) who underwent primary vitrectomy (27-G in 64 eyes, 25-G in 121 eyes) were analyzed.
The 27-G and 25-G groups did not differ significantly in preoperative Early Treatment Diabetic Retinopathy Study (ETDRS) score, age, or preoperative intraocular pressure. The proportions of simultaneous cataract surgery (27-G vs. 25-G: 59.4% vs. 62.4%) and air-filled eyes (76.6% vs. 85.1%) were not significantly different between two groups. Both groups showed significant improvement in ETDRS score at postoperative 1, 3, and 6 months (all, P < 0.0001). Mean gain in ETDRS score from baseline was apparently better in 27-G group than in 25-G group at 1, 3, and 6 months, but there were no significant differences (1 month: 20.3 vs. 13.1 letters, P = 0.0703; 3 months: 22.9 vs. 17.5 letters, P = 0.1561; 6 months: 24.3 vs. 19.3 letters, P = 0.3313). Operation time was apparently longer for 27-G vitrectomy, but there was no significant difference (54.0 vs. 51.1 min, P = 0.3676). The same was observed for postoperative intraocular pressure at postoperative day 1 (19.7 vs. 18.1 mmHg, P = 0.1353). Incidence of postoperative retinal detachment (1.6% vs. 0.8%) and reoperation due to vitreous hemorrhage (6.3% vs. 6.6%) was not different between two groups.
The 27G system is as safe and as useful as the 25G system when used for PDR and can be expected to achieve earlier recovery of postoperative visual acuity.
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- 1.
Oshima Y, Wakabayashi T, Sato T et al (2010) A 27-gauge instrument system for transconjunctival sutureless microincision vitrectomy surgery. Ophthalmology 117(93–102):e2
- 2.
Osawa S, Oshima Y (2015) 27-gauge vitrectomy. Dev Ophthalmol 54:54–62
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Zehetner C, Moelgg M, Bechrakis E et al (2017) In vitro flowanalysis of novel double-cutting, open-port, ultrahigh-speed vitrectomy system. Retina. https://doi.org/10.1097/iae.0000000000001882 (Epub ahead of print)
- 4.
Lin X, Apple D, Hu J et al (2017) Advancements of vitreoretinal surgical machines. Curr Opin Ophthalmol 28:242–245
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Kunikata H, Abe T, Nakazawa T (2016) Heads-up macular surgery with a 27-gauge microincision vitrectomy system and minimal illumination. Case Rep Ophthalmol 7:265–269
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de Oliveira PR, Berger AR, Chow DR (2016) Vitreoretinal instruments: vitrectomy cutters, endoillumination and wide-angle viewing systems. Int J Retina Vitreous 2(1):28
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Khan MA, Shahlaee A, Toussaint B et al (2016) Outcomes of 27 gauge microincision vitrectomy surgery for posterior segment disease. Am J Ophthalmol 161:36–43
- 8.
Khan MA, Kuley A, Riemann CD et al (2018) Long-term visual outcomes and safety profile of 27-gauge pars plana vitrectomy for posterior segment disease. Ophthalmology 125:423–431
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Rizzo S, Barca F, Caporossi T et al (2015) Twenty seven gauge vitrectomy for various vitreoretinal diseases. Retina 35:1273–1278
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Wu RH, Zhang R, Lin Z et al (2018) A comparison between topical and retrobulbar anesthesia in 27-gauge vitrectomy for vitreous floaters: a randomized controlled trial. BMC Ophthalmol 18:164
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Zhang Z, Wei Y, Jiang X et al (2018) Surgical outcomes of 27-gauge pars plana vitrectomy with short-term postoperative tamponade of perfluorocarbon liquid for repair of giant retinal tears. Int Ophthalmol 38:1505–1513
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Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical statement
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Ethical approval
This study was approved by the Ethical Committee of the Nihon University School of Medicine.
Informed consent
Before surgery, informed consent was obtained from each patient following an explanation of the vitrectomy procedures and potential adverse effects of the procedure. For the retrospective study, formal consent is not required.
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Naruse, Z., Shimada, H. & Mori, R. Surgical outcomes of 27-gauge and 25-gauge vitrectomy day surgery for proliferative diabetic retinopathy. Int Ophthalmol 39, 1973–1980 (2019). https://doi.org/10.1007/s10792-018-1030-z
Issue Date:
- Day surgery
- Operative time
- Proliferative diabetic retinopathy
- 25-gauge vitrectomy
- 27-gauge vitrectomy
- Visual acuity


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Oat bran
This morning, while searching on the internet for an oatmeal recipe to make my children for breakfast (experts say it's good for their bones), right after the first options I came across a video called Narco Crops (Narco Cultivos, in the original Spanish), by Azucena Sánchez and Maria Degand. It is quite a beautiful little film, fresh to the point of bordering on the type of visual poetry that reminds one of certain scenes from Tarkovski's Stalker or, more obliquely, of Peter Greenaway's Water Wrackets. The content of the video consists of a map of Mexico drawn on the bottom of what appears to be a teflon-coated container, with the silhouette well outlined in white on a dark background.


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Minnesota | Voting Guide
Registration Deadlines and Election Dates
Voter Registration Deadline: 21 days before Election Day
You may also register during absentee voting by-mail and in-person, and on Election Day at your voting location.
Presidential Primary Election Registration Deadline: February 11
Presidential Primary Election: March 3
Statewide Primary Election Registration Deadline: July 21
Statewide Primary Election: August 11
General Election Registration Deadline: October 13
General Election: November 3
Official Election Websites
More election information at mnvotes.org
Online voter registration available at https://mnvotes.sos.state.mn.us/VoterRegistration/VoterRegistrationMain.aspx
Register at School or Home
Students have a choice about where to register to vote.
Students attending college may register at their campus address or choose to remain registered or register at their permanent or home address.
You may only be registered and vote in one location.
What Type of ID Do I Need to Register?
If you register to vote online, you will need a Minnesota driver's license number, learner's permit, photo ID card number, or the last four digits of your Social Security number.
First-time voters who register through a paper application must provide a driver's license number or the last four digits of their Social Security number. If election officials cannot match that number, you will need to provide a copy of a current and valid photo ID with your name and photo, or a current utility bill, bank statement, government check, paycheck, or government document with your current name and address, when you register or the first time you vote.
If you choose to register on Election Day, you will need to show proof of address and identification. A full list of acceptable forms of proof can be found at https://www.sos.state.mn.us/elections-voting/register-to-vote/register-on-election-day/. You have a couple options. These include:
Showing an ID with current name and address such as a valid Minnesota driver's license, learner's permit or ID, or a tribal ID with name, address, photo and signature;
Showing a Photo ID, even an expired one, and a different document with your current name and address, including any combination of a driver's license, state ID or learner's permit issued by any state, a U.S. Passport, a U.S. Military or Veteran's Health Identification Card, tribal ID with name, photo, and signature, a Minnesota university, college or technical college ID, a Minnesota high school ID, and/or any of the following documents, which can be shown on an electronic device: a bill, account or start-of-service statement due or dated within 30 days of the election for any utility, including phone, TV, Internet, solid waste, sewer, electric, gas or water, banking or credit card, rent or mortgage, residential lease or rent agreement valid through Election Day, or current student fee statement;
Having a registered voter *from your precinct* vouch for you and confirm your address by signing an oath (Note: A registered voter can vouch for up to eight voters. You cannot vouch for others if someone vouched for you); OR
Showing college student ID if your college has provided a student housing list
Finally, if you registered to vote within 20 days of the election, you may get a Notice of Late Registration in the mail. If you do not appear on the rolls, you can use that as your proof of residence to register.
What Type of ID Do I Need to Vote?
Minnesota voters with current and active registrations do not need to show ID before voting.
Where Do I Vote?
Make a plan. Look up your voting site and hours at: http://pollfinder.sos.state.mn.us/
How Can I Vote?
By Mail
You may request an absentee ballot through either a paper application or an online application. If you apply for an absentee ballot online, you must provide an email address and a Minnesota-issued driver's license/ID card number or the last four digits of your Social Security number. Absentee ballot applications must be submitted online or received by your local election office by the day before Election Day.
You must fill out your absentee ballot in front of another registered Minnesota voter or a notary and submit your absentee ballot either by mailing it or by hand-delivering it to your local elections office. If you are submitting your ballot by mail, it must be received by your local elections office before polls close on Election Day. If you hand-deliver your absentee ballot, it must be received by your local elections office by no later than 3 p.m. on Election Day.
You may register to vote at the same time as you vote by absentee ballot, so long as you include a registration form and have shown your proof of address to the person who witnesses your ballot.
Early In-Person
All Minnesota voters may vote "absentee" in person beginning 46 days before Election Day. Unregistered voters may register by bringing proof of address with them to their early voting location.
County elections offices serve as early voting locations during their normal business hours. Cities and towns may provide additional early voting locations as well. All early voting locations are open the last Saturday before Election Day and the day before Election Day. For more information on early voting locations and hours, contact your county election office or city clerk's office
Election Day
Voting sites will be open from 7 a.m. to 8 p.m. on Election Day. If you are in line by the closing time then you must be allowed to vote.
Common Questions/Concerns
Registering to Vote Does Not Affect Your:
Federal Financial Aid
Where you register to vote will not affect federal financial aid such as Pell Grants, Perkins or Stafford loans, or your dependency status for FAFSA
Status as a Dependent on Your Parents' Taxes
Being registered to vote at a different address from your parents does not prevent them from claiming you as a dependent on their taxes
Tuition Status
Being deemed out-of-state for tuition purposes does not prevent you from choosing to register to vote in your campus community
Will registering to vote in Minnesota affect my driver's license or car registration?
After becoming a Minnesota resident, you have sixty days to get a Minnesota driver's license. For more information, you may wish to contact the Minnesota's Department of Public Safety Division of Driver and Vehicle Services.
Fair Elections Center and Campus Vote Project intend the information contained herein to be used only as a general guide. This document should not be used as a substitute for consultation with a licensed Minnesota legal professional.
Last updated August 2019


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Maybe you came down to see us at this week's Museums Showoff. Maybe you just follow us on twitter. But it seems quite a few of you might be interested in joining the Ministry and writing for our blog.
Yes, the Ministry of Curiosity is amazing. But how can you be a part of it? Easy! Become a member by contributing blogs, exhibition reviews, your thoughts on lectures, pictures from openings, posts about your museum style, or maybe even some event ideas of your own!
Submission is easy and our guidelines are basic: love what you do, have fun. We love to hear about the wide variety of projects, research, interests, and ideas swirling around our amazing London cultural community. Think your idea might be a little out there for us? I doubt it. Submit submit submit!
For more information on how you can have your blog published here on our site and promoted on our twitter and facebook, just visit the 'Join the Ministry' tab on the blog.
Get writing, get curious!
Also just look at this picture of us at Museums Showoff. Clearly the Ministry is tons of fun and you want to be a part of it.


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|Photo Delta
Both yes and no.
The airline is undertaking a two-week pilot test from 13th May, on some 55 domestic flights a day where they will allow passengers, in all cabins, to surf the net for free.
This two-week pilot trial runs in all cabins on select short-, medium- and long-haul routes and is perhaps the first step toward offering free in-flight Wi-Fi as part its leading suite of complimentary onboard entertainment options.
"Customers are accustomed to having access to free Wi-Fi during nearly every other aspect of their journey, and Delta believes it should be free when flying, too," said Ekrem Dimbiloglu, Director of Onboard Product. "Testing will be key to getting this highly complex program right – this takes a lot more creativity, investment and planning to bring to life than a simple flip of a switch."
But....yes there is a but, this free test will not support content streaming, so watching the latest episode of your favourite soap or drama will not be possible. It will, however, allow less high bandwidth operations such as browsing the net, emailing, shopping, sending a message or even engaging on social media and that sort of thing.
Delta's initial test on select domestic high-speed 2Ku Wi-Fi-equipped aircraft is designed to understand customer experience preferences, system performance, customer feedback and more. Dimbiloglu noted that due to the complexity of the project, it will likely take several more test phases and lots of listening to ensure the free product Delta delivers, adds value.
"As with any test in uncharted territory, Delta will rely heavily on customer and employee feedback to navigate how to best make free in-flight Wi-Fi a reality," Dimbiloglu said.
Test flight segments will change daily as part of the test structure, but customers will be notified by Delta if they're being tapped for the test via email and a Fly Delta app push notification prior to their flight and upon visiting the Wi-Fi portal on board.
Delta currently offers Wi-Fi on nearly all flights across its domestic and international networks and has installed high-speed 2Ku on 60% of mainline aircraft. Wi-Fi for purchase and free mobile messaging will remain available throughout the test timeframe, just as they are today.
Recommended for you...


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Wednesday, November 19, 2014
Toke Makinwa Looks Stunning For The Kinabuti Show Tonight
23 comments:
She looks like African barbieReplyDeleteReplies
- Anonymous20 November, 2014 01:59
toke when will u stop all this una waka waka. you should start considering getting mature. cause u are getting older. ah ah give itself some respect once ina little while. ehh nDelete
- Anonymous20 November, 2014 07:20
Stop hating.Delete
- Anonymous20 November, 2014 10:10
some one in the house has just heard the word 'hating' because people just use the word stupidly nowadays. which one is hating in 01:59's comment. there is nothing offensive about that commentDelete
- Anonymous19 November, 2014 20:55
- Anonymous19 November, 2014 20:58
She's a stunnerReplyDelete
- Anonymous19 November, 2014 21:08
Ghost thingzReplyDelete
Nice, however that ugly necklace was unnecessary, Also she should have shortened the gown just a bit. No excess fabric dragging on floor. O well!!!! Nice ToksReplyDelete
Fine faceReplyDelete
Flawless. Love me some TokeReplyDelete
- Anonymous20 November, 2014 00:04
whats with the hair up to the belly button??????ReplyDelete
Take a deep breath..whew. relax ,u can't just force it.nyc dress thoReplyDelete
- Anonymous20 November, 2014 00:47
Tokeee...Everywhere u go*Waka abt*Bennie BooReplyDelete
She looks good! :)ReplyDelete
- Anonymous20 November, 2014 02:29
Lovers of sport plz check my blog ckjacob.blogspot.comReplyDelete
- Sunshine20 November, 2014 03:02
What's wrong with her hands?ReplyDelete
- Anonymous20 November, 2014 07:20
I loveReplyDelete
She looks niceReplyDelete
- Anonymous20 November, 2014 08:25
It would have been more befitting if only the upper 3rd of this picture was released for public viewing.ReplyDelete
Toke, you really need to hire a good publicist. Trust me, you wouldn't regret it. It is far better than showing yourself being displayed like a waxed-up statue.
This babe knows how to dresss mehnnnn...I give it to herReplyDelete
she's stunning


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Google+ for Android has just been updated to version 3.6 (18.104.22.168338848), with lots of new features and improvements, such as re-share posts to communitiess, in addition to our current location on our profile and control who can see it via Google+ settings, among many others.
Features of Google+ for Android:
- New Feature: Google+ Communities
- Enjoy magazine style layout in the new tablet version
- Automatically share photos to an Event with Party Mode
- Video chat with up to 9 friends with mobile Hangouts
- Turn on Instant Upload to sync photos from your phone to a private Google+ album
- Check out the What's Hot stream to see trending topics
- View the Nearby stream to see what people near your location are saying
Google+ for Android in action:
Changelog Google+ for Android v3.6:
- New stream design (including comment previews and swiping through photo albums inline)
- Control the volume of posts that you see in your stream from individual circles/communities
- New app setup flow
- Filter search results by best or most recent
- Tell others about a community (by sharing it or sending an invitation)
- Re-share posts to communities
- Share your current location on your profile and control who can see it via G+ settings
Google+ for Android is available for free on Google Play.
Download | Google Play
QR Code:


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We had a great time at Earth Day 2015! The event attracted more than 29,000 people and almost 8,000 of them came car free! Santa Barbara Car Free and the Air Pollution Control District booths were the first stop for more than 800 people who registered to receive prizes donated by Car Free partners. They came using all varieties of transportation, like the pooch riding in his owner's bicycle sidecar. Kids lined up to answer trivia questions about air pollution and transportation from our Wheel of Change.
Our Advertisement for Earth Day 2015 — Click image for full size view.


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PRADERA Parker, Colorado
Welcome to Pradera. A luxury community of new homes for sale in Parker Colorado.
Nestled in the rolling countryside between Parker and Castle Rock, Pradera offers families wide-open vistas with an attitude to match. Life at Pradera is friendly, unpretentious, and very welcoming. Maybe it's the influence of hundreds of acres of beautiful Colorado open space and some of the Denver area's most sought-after new luxury homes in Parker. Maybe it's rounds of golf with neighbors on the private, award-winning course. Or maybe it's having room for kids to play capture-the-flag on spacious home sites.
WHAT WE LOVE: The Amenities
Living in a new home at Pradera gives you much more than a place to hang your hat. It's a place to truly live. Besides having a private golf course and club right in the neighborhood, Pradera families can choose from many other ways to stay active and engaged with their neighbors through the numerous community amenities.
Pradera's 3,100 square foot community center features a competition-size pool, spray play area and a sun deck that's perfect for lazy summer days with friends. Inside, a catering kitchen and party room provide an ideal pool-side resource for everything from children's birthdays to anniversary parties.
The surrounding park is a big draw for Pradera's youth, with a brand new playground, basketball/inline hockey court, two soccer/lacrosse fields and a baseball/softball field. A trail system winds throughout the community's vast open spaces, providing residents with panoramic views and an abundant variety of hikes and bike rides.
CONSTRUCTION STATUS: Choose Your Collection
The European Hillside Collection consists of 28 lots integrated into the naturally rolling terrain. These homesites include large lots with features like courtyards, balconies, patios and decks, where you can enjoy the Colorado landscape as well as the beauty of the Pradera community.
Once you've selected the perfect lot for your new home at Pradera, choose from one of five luxury floor plans within the European Hillside Collection by Celebrity Custom Homes. Crafted in the style of European architecture, this small community will transport you to an intimate community in the European countryside. Enjoy close proximity to the nearby golf course, tennis courts, fitness center, pro shop and neighborhood restaurant located at the golf course clubhouse.
If you're looking to build a new, luxury home from the ground up, then this is the Pradera community for you. With numerous lots to choose from, you can pick the location from the map that's right for you and your family. There are four different custom home builders working within this community – Ades Design Builders, Celebrity Custom Homes, Gregg Design Custom Builders, and Johnson & Sons. Carefully vetted, these builders have strong experience and are passionate about the local Colorado area.
Whether you choose your own architect to design your home at Pradera or select from an existing plan offered by your builder, you're sure to create an experience that is uniquely designed to your specifications from the exterior all the way down to the minor details. The Custom Collection at Pradera offers close proximity to all of the community's amenities. Whether it's the Club at Pradera, fine dining, or area schools, you'll never be far from what you need.
SCHOOLS: The Douglas County School District
No, that happy feeling you have inside isn't because they're leaving. It's because of where they're going. From elementary through high school, Pradera children attend highly respected Douglas County Schools, which means parents can relax and know their kids are getting a great education: one that's only minutes away, making the early morning rush out the door a little easier.
The Douglas County School District is a leader in Colorado's public education, outpacing state performance in every grade and on every subject tested by the Colorado Student Assessment Program (CSAP). Douglas County students exceed the state average by 12 to 21 percentage points. And students continue to widen the gap.
Support and coordination can be found at the district level, but each school has the flexibility to build its own instructional programs. Parents at Pradera can choose from a variety of elementary schools with open enrollment, charter schools, instruction for gifted and talented students, magnet schools, an International Baccalaureate program, Advanced Placement courses, and many other special programs. And the district champions a well-researched, integrated and standards-based curriculum, a rich array of extracurricular offerings and strong community involvement.
Take a look for your self and see what the buzz is all about!
Sort By


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My Story: Fighting for Cannabis Legalization
I am fighting for marijuana (cannabis) legalization in England for my chronic pain. I am a veteran of the U.S. Air Force. I found the love of my life in England and came over here in 2011 to be with him.
I am the child of a Vietnam veteran who was exposed to Agent Orange and many of my brothers and sisters (friends who are also children of veterans) suffer very much.
Thanks to my beginning of life being affected by this chemical, I now have a list of medical problems, such as aching, burning, throbbing, gnawing, shooting, and tingling pain. It is migratory and moves all over my body, causing fatigue, sleep problems, muscle stiffness, depression, anxiety, mood swings, migraines and cognitive function problems.
I also suffer from constant nausea and daily headaches. I have trouble remembering what I just said or did. I may be speaking and suddenly I cannot think of the words to continue and forget everything.
I have been working since I was 13 years old and it is very hard to accept that I cannot work anymore. The doctors here have told me that they are ignorant as to how to help me with my predicament. I can't go anywhere because I am on disability.
I have been trying to get into shape but it is hard when you feel like this. So thanks to the NHS (free medical care), which does nothing for me, I sit every day at home and have no energy. I have trouble eating food because of the nausea and nobody can help us.
My partner obtained some marijuana and guess what? While I could get some, I was mostly pain free. I could eat and sleep, and felt better. Cannabis is a miracle.
I'm writing so people can see what I see — that cannabis is not some horrible thing. That it is a help to those of us in pain. That it is relief from the constant stabbing agony of being trapped in a sick body.
I have written to groups called CLEAR and LEAP. One is a cannabis reform political party in England and the other is law enforcement group opposed to cannabis prohibition.
Why should I be labeled a criminal because I want to have cannabis in my life? My neighbors say they will call the police if they smell cannabis. I am not well enough to survive prison time. I don't make enough money to handle fines.
So my solution is to keep campaigning for cannabis legalization. I want to be able to grow my own and not have to deal with the government. I am sharing my story with you and hope you can spread the word — not just my story but the thousands of others that are too sick or medicated to write to people they feel can help make a change.
I have written to my Member of Parliament, the Deputy Minister Nick Clegg, Normal Baker another MP, and am writing to the Prime Minister.
My doctor looks at me like I am crazy when I mention cannabis as a solution. This country is full on reefer madness. It needs to stop.
Jacqueline Rainwater lives in Roborough, England.
National Pain Report invites other readers to share their stories with us.
Send them to email@example.com
The information in this column is not intended to be considered as professional medical advice, diagnosis or treatment. Only your doctor can do that! It is for informational purposes only and represents the author's personal experiences and opinions alone. It does not inherently or expressly reflect the views, opinions and/or positions of National Pain Report or Microcast Media.
Although I cannot smoke pot anymore due to my illness I have met so many patients who swear by it as a pain reliever and something that adds happiness and productivity to their lives, I am a true, true believer. Coming from the great state of Colorado, where it quickly became obvious that legalizing pot for medical reasons means it should be legalized for any other reason, like trusting adults to be good, decent people, that Coloradans got off their couches and flocked to the polls to get this law passed.
As it turns out, there was no crime wave, no reckless behavior, the cartels had to leave the state, and a lot of money from tax revenues. Just a few reasons it should be legalized everywhere. We need to start trusting adults again despite the small percentage of bad guys. There are many more people who need pot as a pain reliever than there are, seedy drug addicts out there! TIME TO WAKE UP FOLKS!
My name is CC, I'm 39 years old and I believe that my 36 year old sister and I are suffering the same fate as this author.
We are both suffering from a similar, if not the same deliberating disease. We are at such a loss as to what to do because all our doctors have told us that either we're crazy or they can't help us.
I am a marijuana activist in Texas. I, too, believe that cannabis oil is our only answer to this neurological disease that seems to have no other answers. I've done a small amount of research, but European studies are stating over and over again that cannabis oil either cures or slows down the progression of all neurological disorders including mental illnesses.
I struggle daily with the legality of my medication. It's not easy being dependent on something for your well being. It is the only thing I've found that has come close to touching the pain that I have. My pain fluctuates, but is rarely less than 6 out 10 on a pain scale (10 being the worst) without cannabis. Living life with less pain is wonderful, but being able to function better cognitively is a god send.
I urge everyone to try to understand this from a patient's stand point. When marihuana is all you have that makes your life bearable and it's not available, then it makes people desperate. It's not easy hearing that there's no problem (no diagnosis) and no solution. Cannabis is the neurological disorder's solution and friend.
Please find me on my website or on fb.com/castalovespell I'm always looking for more people who have similar symptoms so we can fight this disease! Work smarter, not harder is my motto!
Thank you Kimberly Kay Miller for what you wrote. Right now I am fundraising trying to get enough money to move somewhere I can get Cannabis. Do I want to move? No not really I like my life in England. http://www.gofundme.com/71xumo If they could only legalize it here for me I could stay. I really don't like asking for help money wise but what else can I do? I make only my disability money.
I was tried to work since getting sick and I can't. I tried to get an online customer service job and it was so hard to concentrate because of my many prescriptions. I also have Asthma, spondylosis, fibromyalgia, degenerative disk disease, migraines, sciatica, multiple back surgeries as well. My life is one big pain filled nightmare.
Who really wants to sit on the couch all day consumed by symptoms and side effects? I certainly don't but if the laws do not change that is exactly what my life is. I used to be so vibrant and had so many things to do. I would make my own clothes and cook dinners for my family.Now thanks to fibromyalgia and everything else my quality of life has become dismal.
This is not my dream.. sitting here begging for help but the pharmaceutical companies, the NHS, my Doctors and the current laws I am left with no other choice. I am so tired of feeling like this when all it takes is cannabis to alleviate many symptoms and at least get rid of that feeling that I am going to throw up yet again. My chest hurts my body hurts I am feeling dizzy writing this and I fear I may have to go throw up again.. please help me.. please.
Ms. Rainwater is a true pain warrior writing this piece so all can see that Marijuana is not the Devil Drug many believe it to be. Harmless in comparison to many pain medications in the mere fact that you cannot overdose on marijuana.
Since being able to obtain the marijuana she had regained the pain free life she thought she had forever left behind. Now, whenever she can obtain the illicit substance, she is transported back to a time of life she can otherwise only remember.
We need to continue to fight for the legalization of medical marijuana as Ms. Rainwater has done for years. I salute your efforts!
See Link for the following page:
"Opposition to Kentucky HB 1-Reform HB 217 aka "Pill Mill Bill"
Then in March, federal Drug Enforcement Agency agents seized a small shipment of medical marijuana in transit from Prosser's state-approved caregiver. Though she was never criminally charged, Prosser was crushed. She said caregivers became afraid to supply her with the medicine she needed so badly.
Sadly, this story comes much too late for this Pain Warrior. She took her own life as a result of her continued efforts to obtain the Marijuana she needed to stave off her chronic pain, but police and DEA continued to harass her caregivers and she was still unable to obtain the product on a consistent basis. Having extreme adverse reactions to nearly every pharmaceutical she had been tried on, I guess that was all she felt left for her to do. the following is an excerpt from a local Montana paper recalling the event following her suicide:
Quote from Missoula Independent:
"In July, she penned an op-ed piece in the Billings Gazette, pleading with Montana's politicians and her fellow citizens to speak out against the DEA's actions and improve the lives of people like her.
"Give me liberty or give me death," she wrote. "Maybe the next campaign ought to be for assisted-suicide laws in our state. If they will not allow me to live in peace, and a little less pain, would they help me to die, humanely?"
We must continue to fight the fight for people like Robin Prosser who couldn't take it anymore and fought the good fight as long as she could.
See Link for the following page:
"Opposition to Kentucky HB 1-Reform HB 217 aka "Pill Mill Bill"
Amen!!! Let's legalize this beautiful natural plant. It is a win, win situation!!!


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Ingmar Bergman
Through the eyes of ten-year-old Alexander, we witness the delights and conflicts of the Ekdahl family, a sprawling bourgeois clan in turn-of-the-twentieth-century Sweden. Ingmar Bergman intended Fanny and Alexander as his swan song, and it is the legendary director's warmest and most autobiographical film, a four-time Academy Award–winning triumph that combines his trademark melancholy and emotional intensity with immense joy and sensuality.
Janus Films is proud to present a touring retrospective spanning Abbas Kiarostami's nearly five-decade career. This series includes new restorations, undertaken by the Criterion Collection and MK2, of The Koker Trilogy, Taste of Cherry, The Wind Will Carry Us, and rarely screened shorts and documentaries.
Abbas Kiarostami
DCP, 35 mm, Blu-ray
The final film from the late, beloved Agnès Varda is a characteristically playful, profound, and personal summation of the director's own brilliant career.
Agnès Varda
DCP, Blu-ray, DVD
This widely acclaimed film from Soviet director Elem Klimov is a stunning, senses-shattering plunge into the dehumanizing horrors of war. As Nazi forces encroach on his small village in present-day Belarus, teenage Flyora (Aleksei Kravchenko, in one of the screen's most searing depictions of anguish since Renée Falconetti's Joan of Arc) eagerly joins the Soviet resistance.
Elem Klimov
Soviet Union,
DCP, Blu-ray, DVD
Seattle, 1984. Taking their camera to the streets of what was supposedly America's most livable city, filmmaker Martin Bell, photographer Mary Ellen Mark, and journalist Cheryl McCall set out to tell the stories of those society had left behind: homeless and runaway teenagers living on the city's margins
Martin Bell
United States,
DCP, Blu-ray, DVD


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Betsy Wolf Regn
Artistic Director
Betsy Wolf Regn graduated Magna Cum Laude from Muhlenberg College with a B.A. in English Education and has since received her Master's in Education. She taught English and Drama for 11 years in Abington School District, then retired to join Wolf PAC as a full-time staff member. Betsy is our Camp Director, directs and choreographs our 6th-12th grade performers, and oversees all of Wolf PAC's mainstage productions. She is married to an amazing man and has two budding performers of her own: a daughter in 2nd grade and a son in 1st grade.
Extension 106


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Had a fling with Kyle Houston
Although Kyle's friend Paul married Jewel, in college Kyle had a fling with the brazen blonde, but it didn't last very long.
Married to Paul Flare
Although Paul and Jewel are married to one another, they spend more time with other people and apart then they do with each other. Unfortunately their daughter Stacy gets lost in the shuffle between them when they are on their on and off phases..
Had a fling with Nate Pryce
When Jewel first came back to town she decided to spice things up in her life and she chose Nate Pryce as a means of making that happen. The two hooked up with one another when Jewel realized that he was Don's brother-in-law. Eager to get under Don's skin Jewel decided to start seeing Nate for secret passion sessions, but when she learned that her sister Cori was the object of Nate's curiosity, she decided to lay it on thick and put more efforts into seducing Nate just to annoy her sister. Of course now it seems that Jewel's progress has been pushed back a bit as Nate focuses on taking care of his friend Mindy during her time of need.
Had a fling with Don Leveski
Before Don and Stephanie finally became an item Don and Jewel saw one another briefly during his college years. Their relationship didn't last very long as he was in love with Stephanie and Jewel was interested in other prospects.


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Create an Account - Increase your productivity, customize your experience, and engage in information you care about.
View All Calendars is the default. Choose Select a Calendar to view a specific calendar. Subscribe to calendar notifications by clicking on the Notify Me® button, and you will automatically be alerted about the latest events in our community.
December 8, 2018, 8:00 AM - 2:00 PM @ North Miami Beach Senior High School
Holiday arts and crafts, t-shirts, foods, candles, clothing and more. Fun the entire family.
December 8, 2018, 6:00 PM - 11:00 PM @ City Hall
A snow advisory has been issued for North Miami Beach! Bring the entire family to enjoy a snow mountain, rock climbing walls, rides, carnival games, bounce houses, music, and arts & crafts.


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Preview: Fast-Track Incubator
Friday, August 30, 2019
While celebrating the first five years of the Hub101, the founders of the business incubator looked back on a string of successful companies to come out of the program.
"We want startups to move out. We want them to grow and then outgrow the space," Gerhard Apfelthaler, dean at California Lutheran University's School of Management in Thousand Oaks, which runs Westlake Village-based Hub101, told the Business Journal.
Read the full story in the Sept. 2 issue of the San Fernando Valley Business Journal.


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Tagged: Keap1
A virtual reality for Parkinson's: Keapstone
In 2017, Parkinson's UK – the largest charitable funder of Parkinson's disease research in Europe – took a bold step forward in their efforts to find novel therapies.
In addition to funding a wide range of small and large academic research projects and supporting clinical trials, they have also decided to set up 'virtual biotech' companies – providing focused efforts to develop new drugs for Parkinson's, targeting very specific therapeutic areas.
In today's post we will look at the science behind their first virtual biotech company: Keapstone.
A virtual world of bioscience. Source: Cast-Pharma
I have previously discussed the fantastic Parkinson's-related research being conducted at Sheffield University (Click here to read that post). Particularly at the Sheffield Institute for Translational Neuroscience (SITraN) which was opened in 2010 by Her Majesty The Queen. It is the first European Institute purpose-built and dedicated to basic and clinical research into Motor Neuron Disease as well as other neurodegenerative disorders such as Parkinson's and Alzheimer's disease.
The research being conducted at the SITraN has given rise to multiple lines of research following up interesting drug candidates which are gradually being taken to the clinic for various conditions, including Parkinson's.
It's all very impressive.
And apparently I'm not the only one who thought it was impressive.
Hey DJ, I-so-sit-rate!
The title of this post probably reads like the mad, drug-fuelled scream of a drunk Saturday night party animal, but the elements of it may be VERY important for a particular kind of Parkinson's disease.
Mutations in a gene called DJ-1 can cause an early onset form of Parkinson's disease. The protein of DJ-1 plays an important role in how cells handle oxidative stress – or the increase in damaging free radicals (explained below).
This week researchers announced that they have found an interesting new therapeutic target for people with DJ-1 associated Parkinson's disease: A chemical called Isocitrate.
In this post, we will discuss what DJ-1 is involved with Parkinson's disease, how isocitrate helps the situation, and what the results of new research mean for future therapeutic strategies.
Source: Listchallenge
In 2017, we are not only observing the 200 year anniversary of the first description of Parkinson's disease (by one Mr James Parkinson), but also the 20th anniversary of the discovery of the first genetic variation associated with the condition (Click here to read more about that). Our understanding of the genetics of Parkinson's disease since 1997, has revolutionised the way we look at Parkinson's disease and opened new doors that have aided us in our understanding.
During the last 20 years, we have identified numerous sections of DNA (these regions are called genes) where small errors in the genetic coding (mutations or variants) can result in an increased risk of developing Parkinson's disease. As the graph below indicates, mutations in some of these genes are very rare, but infer a very high risk, while others are quite common but have a low risk of Parkinson's disease.
The genetics of PD. Source: Journal of Parkinson's disease
Some of the genetic mutation need to be provided by both the parents for Parkinson's to develop (an 'autosomal recessive' mutation – the yellow circles in the graph above); while in other cases the genetic variant needs only to be provided by one of the parents (an 'autosomal dominant' mutation – the blue circles). Many of the genetic mutations are very common and simply considered a region of increased risk (green circles).
Importantly, all of these genes provide the instructions for making a protein – which are the functional parts in a cell. And each of these proteins have specific roles in biological processes. These functions tell us a little bit about how Parkinson's disease may be working. Each of them is a piece of the jigsaw puzzle that we are trying to finish. As you can see in the image below, many of the genes mentioned in the graph above give rise to proteins that are involved in different parts of the process of autophagy – or the waste disposal system of the cell. You may notice that some proteins, like SCNA (otherwise known as alpha synuclein), are involved in multiple steps in this process.
The process of autophagy. Source: Nature
In today's post we are going to look at new research regarding just one of these genes/proteins. It is called DJ-1, also known as Parkinson disease protein 7 (or PARK7).
What is DJ-1?


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If you're aged between 16 and 19 you can
apply for an Endeavour Card from Suffolk
County Council and receive discounted bus
travel across the county.
It's easy to apply just click
the logo above for more
So whether you're heading off to college,
starting a new job or hitting the town,
it's now even cheaper with Galloway.
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My Health Record general enquiries
My Health Record Help line
Phone: 1800 723 471 (option 2)
For help with:
- registration enquiries for My Health Record
- general enquiries or concerns relating to the My Health Record system (e.g. privacy and security)
- clinical safety related enquiries
Healthcare Identifiers (HPI-Is, HPI-Os, IHIs)
Healthcare Identifier Service Enquiry Line
Phone: 1300 361 457
Email: healthcareidentifiers [at] servicesaustralia.gov.au
For help with:
- registering your organisation as a Seed or Network and getting a Healthcare Provider Identifier – Organisation (HPI-O)
- registering as an individual healthcare provider and getting a Healthcare Provider Identifier – Individual (HPI-I)
Digital credentials (Medicare certificates, NASH PKI certificates)
eBusiness Service Centre
Phone: 1800 700 199
Email: ebusiness [at] servicesaustralia.gov.au
For help with:
- enquiries relating to Medicare and NASH PKI certificates
- installing your Medicare and/or NASH PKI certificates
- locating lost or forgotten passwords for PKI certificates and tokens
PRODA Help
Phone: 1800 700 199
For help with:
- Provider Digital Access (PRODA) support queries
HPOS Help
Phone: 132 150
For help with:
- Health Professional Online Services (HPOS) support queries
Clinical software technical support
Contact your clinical software vendor
For help with:
- clinical software technical support and trouble shooting (e.g. error messages)
- installing Medicare and NASH PKI certificates
Digital Health general enquiries
Australian Digital Health Agency Help Centre
Phone: 1300 901 001
Email: help [at] digitalhealth.gov.au
For help with:
- developers interested in connecting to My Health Record
- using the My Health Record eLearning platform and clinical software simulators (on-demand training)


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I procrastinated. I had a few ideas for writing tip 2, but nothing concrete. So I decided to look around and see what others were posting. I checked out Tess Gerritsen's blog.
You can find it here.
And what did I read? In her post titled "But I don't know anything interesting" she touches on "write what you know" and had this to say:
"Are you … forced to write about what you know? Absolutely not …you should write about what you want to know."
That's why I love her blog. Head on over there and read the entire post. Heck, read the entire blog. She has some very interesting things to say.
Wednesday, January 10, 2007
Tess's take on "write what you know"
Posted by NL Gassert at 8:49 PM
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Plymouth City Museum and Art Gallery wins the Favourite Museum or Historical Attraction Category in the Primary Times Reader Star Awards 2017 - The Box, Plymouth
By: Jo Clarke
Added: 21 November 2017
Although its building is currently closed for the redevelopment of The Box, the Plymouth readers of the Primary Times have voted for Plymouth City Museum and Art Gallery as their 'Favourite Museum or Historical Attraction' in this year's Reader Star Awards.
While construction work for The Box is underway Museum staff are running a 'Museum On Tour' programme which is taking exhibitions, partnership projects and activities to a variety of offsite venues across the city and beyond.
Family-friendly events during the school holidays and weekends are a key part of the 'Museum On Tour' programme. Over the past few months they have included arts and crafts workshops, storytelling sessions and natural history events.
The interest in the Primary Times Reader Star Awards continues to grow each year. Over the last couple of months, the highest recorded number of readers voted for their favourite family friendly places and people in the area, in a specially designed online survey.
The awards are distinctive in nature, due to their authenticity. They are chosen, organically, by the readers of Primary Times, namely local families with primary school aged children.
Local families were informed of the questionnaire in Primary Times, a family friendly magazine that is delivered to primary schools across Plymouth. With a distribution of 26,000 copies the magazine reaches 94 primary schools in Plymouth. Parents of children aged 4 to 11 across the city cast their nominations in an online survey.
There were 8 different categories asking readers for their favourite: family attraction; family eating place; indoor play or activity centre; outdoor activity centre; museum or historical attraction; sports venue; party venue or entertainer; theatre or arts centre.
One tightly fought-after category was that of favourite Museum or Historical Attraction which garnered a broad spectrum of answers. The interesting artefacts, historical stories and fun family events ensured that Plymouth City Museum and Art Gallery gained the most votes.
Councillor Glenn Jordan, cabinet member for culture said: "We are so pleased to receive this accolade and would like to thank the Primary Times readers for giving us their votes. Our motto ever since the Museum and Art Gallery closed in September 2016 has been 'The building is closed but the service continues.' Staff have worked extremely hard since then to provide a great family-friendly offer in venues such as the Guildhall, the Council House and the Mayflower Museum. This award is a testament to their effort and creativity. No doubt there will be plenty more family fun to follow in 2018."
Linda Edwards, Publishing Editor at Primary Times said: "We are thrilled with the extraordinary response to this year's Reader Star Award survey and we'd like to say a massive thank you to all the readers who took part. The results are sure to help other local families decide what to do and where to go. Each individual category winner deserves worthy recognition, as they are clearly offering something that our readers want."
To can stay up-to-date with the 'Museum On Tour' programme by visiting the what's on section of www.plymhearts.org
You can read more about the Primary Times Star Awards at www.primarytimes.net/plymouth
For more details about the Primary Times Reader Star Awards please contact Alicia Coles or Kirsty Woodgate on 01626 891944 or email firstname.lastname@example.com or email@example.com
Editors Notes:
- The Primary Times Reader Star Award survey was featured in the Back to School magazine and 26,000 copies were distributed to Primary Schools in Plymouth.
- Aside from the overall winner, there were 8 different categories asking readers for their favourite: family attraction; family eating place; indoor play or activity centre; outdoor activity centre; museum or historical attraction; sports venue; party venue or entertainer; theatre or arts centre.
Latest news
Covid 19 Story Collecting!
The Museum of Barnstaple and North Devon
Topsham Town Walking Trails
Topsham Museum
Nello's Long Table, 2021
Topsham Museum
New Book Available
Newton Abbot Town and GWR Museum
Torquay Museum launches Crowdfunder Campaign
Torquay Museum
The National Lottery provides support to help Torquay Museum reopen
Torquay Museum
Topsham Secret Gardens 2021
Topsham Museum
Market Gardening in Topsham: new booklets available
Topsham Museum
Museum Closed Until Further Notice
Dawlish Museum
Lyn and Exmoor Museum
Regular Opening for Ashburton station
South Devon Railway
South Devon Railway Temporary Closure
South Devon Railway
Bovey Tracey Heritage Centre
Bovey Tracey Heritage Centre Summer Season
Bovey Tracey Heritage Centre
Documentary Photography Open
The Museum of Barnstaple and North Devon


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Those in the midst of a domestic violence situation will soon have a new safe haven in central Ohio.
The CHOICES Domestic Violence Shelter is being upgraded to a new 46,000 square foot facility. For the safety of those seeking refuge, the locations of both facilities are unlisted.
"When someone calls in imminent danger even if we don't have a bed we will find room for them," Jamie Jones, a case manager with CHOICES domestic violence shelter, said.
Jones says she helps domestic violence survivors with housing, counseling and safety plans but there often isn't enough room to accommodate everyone's needs.
"Sometimes we have three or four families in one room, you will have a mother sleeping on a bunk bed with three of her children."
Shelter directors say the current location has 51 beds but the demand is higher than the shelter can service.
CHOICES staff says they frequently house 73-75 people a night while keeping a continuous waiting list.
But a new CHOICES Domestic Violence Shelter is looking to give even more survivors a sense of security.
Dozens gathered Friday as the roof was raised on the new 46,000 square foot facility.
It will offer more security, a playground even a kennel so those escaping violent situations don't have to leave their family pets behind.
The new center will also offer 120 beds.
The CHOICES center is scheduled to open by the end of the year.


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Enticing aphrodisiac mist to induce lust, desire, and playfulness. Leave your inhibitions outside the bedroom door and have fun making your partner happy to be your sex poppet. Play dirty!
Use to spritz your bed, linens, even yourself. You can also use this in your love and sex rituals by spraying in your work space or altar area where you are burning candles.
Fragrance is Pomegranate, Narcissus, and other essential oils whose properties are for making your lover endlessly attentive and desire you obsessively.
Always test small amount on skin for allergic reaction if you plan to wear essential oils as a fragrance.
If you are interested in the Adam & Eve poppets pictured on the label, you can purchase yours here: http://www.barefootwitcheryshoppe.com/adam-eve-poppet-pair-voodoo-dolls-poppets-dollbabies/


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The Dentacoin price development
January 9, 2018 8:10 am,
Dentacoin (DCN) price analysis
Ethereum has an actual possibility to be the most important Blockchain platform also in future, Blockchain based B2C manufacturing explanation will be the genuine winners on the market. Dentacoin, for instance, is a tradition token for the worldwide dental business. To one side from being deliberate as an industrial means of expense, Dentacoin is increasing many tools with a regular point: to generate a group of people among patients and dentists and therefore – to get better on the whole treatment superiority worldwide. At the same time, dentists will attain major financial success, as they will have a devoted patient base to help them progress the quality of examining and action provided. In addition, costs of all market contributors will be condensed.
These results are sustained by the real-world knowledge of the first partner clinics. At present, all preceding expectations are met.
The value of Dentacoin (DCN)
The Dentacoin user network has developed extremely with over 3500 recently scheduled users on the Dentacoin tools. The market response to the present growth with a sequence of success: Dentacoin reached a latest all-time high and traversed a value of $0.005, the 24 h trading volume exceeded $50 million, a market cap of over $2 billion was accomplished promising DCN a rank in top 30 cryptocurrencies on coinmarketcap.
Short-term (5 years): First 3 global Operations are to produce 0.1% of the objective market share. Medium-term (10 years): getting 1% of the objective market all the way through the industrial Health Database, Dentacoin Insurance, and operating Platform. Long-term (25 years): In the designed rollout phase 10% of the objective market share will be attained.
The estimation of the potential value is based on the number of Dentacoin wallets formed. Within the first 3 phases of its expansion, Dentacoin establishment aspires to attain a market share of 10%. In the worldwide dental commerce, this 10% market share means 600 million patients and 200 000 dentists that is 12.5% of the entire dentists, with the Dentacoin value-creating tools. 10% of the market share, with an equivalent rate of USD 60 per patient and USD 600 per dentist, a corporation value of in the order of USD 36.12 billion is produced. USD 3.6 billion per 1% market share.


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Term plan premiums1 min read . Updated: 11 Feb 2019, 08:20 AM IST
- Here is a list of premium rates for some policies of a sum assured of ₹ 1 crore across three age categories for policy terms are 30, 25 and 20 years.
- The list of 15 policies has been sorted on the basis of claims settlement rate.


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Tis the season to avoid online scammers In a bid to avoid Christmas crowds, online shopping during the festive season is very appealing. And while the ease and convenience of shopping from the comfort of home is a positive, it's still important to be aware of simple security measures to ensure … [Read more...] about Christmas Safety
House deposits – is Airbnb the answer? New company offering down payments with a catch
Down payment with a catch It's getting harder and harder for many to enter the housing market, but a new start-up in America is making it a little easier for those wanting to purchase a home…but it comes with a catch. A 29-year-old entrepreneur from Seattle, Yifan Zhang has come up with a … [Read more...] about House deposits – is Airbnb the answer? New company offering down payments with a catch
Airbnb – what are your rights?
Do you have rights to share your home? Airbnb has become a central player in the sharing economy in the last decade. While its usage has presented opportunities to ease the financial burden of a mortgage, there are legal implications that hosts of strata-titled properties should be aware of. In … [Read more...] about Airbnb – what are your rights?
Cyclone season is upon us
That's not a cyclone…this is a cyclone Although the effects of Cyclones Debbie, Yasi, Marcia and Larry are generally well known, these are dwarfed by Cyclone Mahina. Cyclone Mahina is the deadliest cyclone in recorded Australian history, striking Bathurst Bay in Cape York on the 4th March 1899, … [Read more...] about Cyclone season is upon us


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When you have been charged with Drunk Driving charges, you are going to need a defense lawyer that can put your needs first. At The Law Office of John M. Phillips, LLC, we understand how to make the most out of every detail in a case, and because of this skill we have seen great success with our clients in the Green Cove Springs area for 14 years.
The Law Office of John M. Phillips, LLC specializes in defending clients who are facing Drunk Driving charges. When you are facing accusations anywhere in Green Cove Springs, count on us to have your back in any court. We have 14 years of experience defending clients charged with Drunk Driving offenses, and we are more than happy to bring this to your case.
When you need help with Drunk Driving matters, The Law Office of John M. Phillips, LLC is here to help you. We have 14 years of experience in working on these matters, and are confident we can use this experience to help those in Green Cove Springs.
Get Our Help Today!
Here at The Law Office of John M. Phillips, LLC, we devote ourselves to the successful legal representation of our Green Cove Springs area clients. When you work with our team, we make sure your Drunk Driving case is ready to be taken seriously in court. Give us a call today at (904) 444-4444 so that you can get the results you want.
$2.6 Million Jury Verdict against Volusia County. Trial televised on Good Morning America.View More
Represented the family of Jordan Davis and oversaw criminal prosecution of his killer, media relations of internationally reported cases and confidential civil settlement.View More
Confidential settlement of over 100 cases against a pediatric dentist who faces prosecution for fraud based on abuse of children.View More


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Ina Kent
Ina Kent
Ina Kent founded her eponymous bag label in Vienna in 2007. Ina Kent's bags and accessories are made from fine Italian leather and are available in a multitude of colors from metallic to vegetable dyed, as well as a variety of shapes and sizes. Kent's bags stand out as multifunctional in their ability to accommodate your personal preference – the tenor 4 bag for example can be worn in 6 different ways thanks to its clever design. In fact every one of Ina Kent's bags is highly customizable and comes accompanied with a little manual demonstrating some of its many uses. As Ina Kent will tell you, "the broad spectrum of possible combinations and colors enables you to create individually tailored solutions."Show lessRead moreFabian
Siebensterngasse 50 , Vienna
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Jacksonville FL Family Photographer {The beach with the J Family}
This family had a session scheduled it seems like, forever ago. But the weather kept making us put it off over and over again. Finally, it looked like we were going to have a wonderful evening, so we quickly got to the session spot. It was pretty dismal when we got there. However, I knew I could work a little editing magic so we went ahead with the session.
This sweet little guy was not a fan of me taking his photo. He was way more interested in playing in the water than the crazy lady running around with a camera. The pup pretty much felt the same, haha.
However, we were able to get so many great images for this family's session and I hope they love them as much as me.
I can't wait to see what the future has in store for this gorgeous family and can't wait to see them again!
Looking for the Jacksonville FL Family Photographer email me at firstname.lastname@example.com


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Photo by jetalone
The first time I encountered green curry was when my colleagues and I went to Bali Thai, for a fellow colleague's farewell dinner. I didn't know what to expect as I've never had it before. I was surprised at how creamy, yet spicy it was. At that time, I was on a cooking binge so I searched and found a relatively simple (but tedious) recipe for green curry from scratch.
For the green curry paste
* 15 large fresh green hot chillies
* 3 shallots, sliced
* 9 cloves garlic
* 1 tsp finely sliced fresh galangal
* 1 tbsp sliced fresh lemon grass
* 1/2 tsp finely sliced kaffir lime rind
* 1 tsp chopped coriander root (or substitute coriander stems if unavailable)
* 5 white peppercorns
* 1 tbsp roasted coriander seeds
* 1 tsp roasted cumin seeds
* 1 tsp sea salt
* 1 tsp shrimp paste (omit this is you're going vegetarian)
For the curry
* 400 grams beef (a little less then 450g)
* 1 tbsp cooking oil (corn, safflower or peanut oil, not olive oil)
* 3 tbsp green curry paste (more if you like it spicier)
* 2 1/2 cups coconut milk
* 2 kaffir lime leaves, torn
* 5-10 small fresh Thai eggplants, quartered
* 2-3 fresh red chilies, sliced diagonally
* 1/4 cup sweet basil leaf (optional)
* 1 1/2 tbsp fish sauce (or salt if you're going vegetarian)
* 1 1/2 tsp palm sugar (or regular sugar if you don't have any)
* Sweet basil leaves and red chili slices for garnish
For vegetarian:
2 cups napa cabbage or chinese cabbage, shredded
1 medium red pepper, cut into thin strips
1 medium carrot, cut into matchsticks
1 cup fresh or canned straw mushrooms
1/2 cup canned baby corn
1 cup tofu puffs (or firm tofu cubes that have been deep fried)
1/4 – 1/2 cup Thai basil leaves, loosely packed.
Toast the spices in a frying pan until they're fragrant but not for too long as they burn easily. Combine coriander seeds, cumin and peppercorn in a mortar, pound well. If You don't have a mortar and pestle, you can use a dry blending attachment that usually comes with the blender. Transfer to a bowl and put aside.
Pound the chilies and salt together well. You can use a blender for this, just try not to add in too much water. Add the remaining ingredients except shrimp paste, pound until mixed well. Add the cumin mixture and shrimp paste, continue pounding until smooth and fine.
Slice the beef into thin pieces, about about 1/3″ (3 cm) thick. Sauté the green curry paste in oil over medium heat until fragrant, reduce the heat, gradually add 1 1/2 cups of the coconut milk a little at a time, stir until a film of green oil surfaces.
Add the beef and kaffir lime leaves, continue cooking for 3 minutes until fragrant and the beef is cooked through. Add the remaining coconut milk, season with palm sugar and fish sauce. When the mixture returns to a boil add the eggplants. Cook until the eggplants are done, sprinkle sweet basil leaves and red chilies over, then turn off the heat.
Garnish with sweet basil leaves and red chilies before serving with hot rice.
Note: The last time I made this, I used all the paste that I made (yeah, all 15 sticks of chili) as I thought that the curry needed to be thicker and spicier. It depends on how spicy you want it. You can also substitute the beef with chicken or fish, though that changes the cooking time. Give it a go and tell me what you think.