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Remove Small Varicose & Spider Veins with Adelaide's Sclerotherapy Specialists
Be free from spider veins and live your life!
If you suffer from small varicose veins and spider veins, it's time you tried sclerotherapy treatment from Adelaide's sclerotherapy specialists.
Sclerotherapy treatment is an effective, fast, pain free solution to remove your unpleasant or uncomfortable leg veins. Almost all the troublesome veins can be eliminated within one to three treatment sessions.
Sclerotherapy effectively treats:
- small varicose veins
- spider veins
- reticular veins
The clinical process involves micro injections of specialised formula directly into the veins to obliterate them. The body then naturally absorbs the vein remnants, leaving you with clearer skin and better blood flow.
This time tested treatment has been around for nearly a hundred years and has seen thousands of people rid themselves of unsightly veins, so they can enjoy life to the fullest. As a premium treatment option, it is fast and effective and loved by people across Australia with results that can last for years.
For a healthy and more fulfilling life, sclerotherapy treatment is a cost effective way to rid your body of these veins and regain confidence and the freedom to express yourself.
You are in safe and professional hands at Laser Skin & Vein Clinic. We will delicately and expertly administer the treatment in our well established Adelaide clinic.
Stop worrying, start treating.
More Information - Spider & Varicose Vein Treatment
What is the cost of Varicose & Spider Vein treatment?
Prices start from $220.
The cost of sclerotherapy can alter depending on the area that needs attention and the severity of the varicose and spider veins. We'd be happy to talk you through your needs with a thorough consultation and advise you of the treatment cost in our Adelaide clinic.
Here's what you can expect from sclerotherapy treatment:
The small needle penetrates the skin less than one millimetre in depth. The sclerosant solution is then injected straight into the vein which causes lining irritation, leading to the collapse of the vein. The body then uses its own heightened intelligence and reabsorbs the vein and its materials back into the bloodstream.
Sclerotherapy is not a painful treatment. Most patients report no more discomfort than a standard appointment for eyebrow plucking or leg waxing.
Often hereditary or hormonally influenced, leg veins are a problem for many people, especially women, that can damage self confidence and cause discomfort or even worse lead to pain, deep vein thrombosis, blood clots and more. By treating them with sclerotherapy, you can avoid any further complications through a non invasive treatment that has barely any downtime. You can't go wrong!
Is sclerotherapy safe?
Yes. Especially when it is conducted by expert and well trained hands like you will find at Laser Skin & Vein Clinic.
What can I expect after treatments?
Whilst there may be some initial minimal swelling and red dots, after no more than two weeks the veins begin to break up and fade and continue to fade for approximately eight weeks, depending on the severity of the veins.
Although one to three sessions can clear up to 80 per cent of veins, after six to eight weeks any residual veins can be easily treated. Maintenance treatments are often performed about three to five years later, as new veins develop.
Normal activities and lifestyle can be resumed straight away and there should be no interruption to your life, making it the best treatment option for prominent veins.
Are there any complications, side effects or treatment failures?
Sclerotherapy is one of the safest and most reliable vein treatments available. Allergic reactions are extremely rare (with an allergy rate of approximately 1:10,000).
A condition called matting develops in about five per cent of patients, which looks similar to light bruising or a pink patch on your skin and often disappears over three to six months.
Larger veins may develop small blood clots within them. This is part of the treatment process and is in no way dangerous and are easily removed. These clots do not break off and travel.
Sclerotherapy is ineffective if major varicose veins feed the spider veins. It is, therefore, necessary to have these veins treated first. On occasion, a painless duplex ultrasound scan is required to accurately evaluate the veins.
Rest assured that we will discuss any allergies, special conditions or concerns during your consultation.
Reference Material
FULL sclerotherapy
$395 per treatment.
Half sclerotherapy
$275 per treatment.
*note more than one treatment may be required as directed by the Doctor.
Get in contact with our warm and knowledgeable staff today to discover more about this life changing treatment.
Spider Vein Treatment Blog
What are Spider Veins and How to Get Rid of Them
What Are Spider Veins? Spider veins can differ in appearance from person-to-person, but typically consist of a cluster of tiny veins stemming off each other, resembling a 'spider web'. Some of their main features include: Usually found on the legs or face Appear close...read more
Sclerotherapy: Treatment for Spider Veins
Do you suffer from unsightly spider veins? If so then don't despair because there is a minimally invasive and effective cosmetic treatment known as sclerotherapy that effectively removes the fine surface veins. You will typically notice the veins start to fade away a...read more


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Title: COO
Website: nic.best
Twitter: @dotBestSEO
LinkedIn: /honore-adrien
Location: Paris, France
Time spent in the domain industry: 5 years
Favourite extension: .Best
Tell us which domain you wish you owned: the.best
Your mentor: Elon Musk
Describe your company. How long have you been there, and what led you to this career choice?
Digital, Digital Marketing, technology, Everybody wants to be the Best
Can you tell us about how your service or product helps deliver value to your customers?
Best is a word know worldwide, with a strong definition, the extension .Best give a high value to a brand, name and business.
How does your career compare to what you envisioned in your youth?
Far from what I was supposed to become but life is a surprise, in order to be happy, learn and enjoy what is coming to you.
How would you describe what you do in a single sentence to a stranger?
I will help you to be the best.
Latest and greatest accomplishment in your career?
Become one of the owner of the .Best
Describe a recent challenge that you overcame.
Starting this TLD adventure.
What are your thoughts on the new TLDs?
They will open new possibilities.
How has GDPR affected your business, if at all?
Yes on the "whois" side of things.
What are you most looking forward to at the upcoming NamesCon?
I am ready to discover new things as it is my first year attending.
If you had fifteen extra minutes each day, what would you do with them?
I would spend them with my family.
What's the most recent thing you learned (big or small)?
I learn about SEO.
Who has been the biggest influence on your life, and what did they teach you?
My Dad. He taught me about courage, strength, and honour.
What are you proudest of in your life?
My son.
What was the best surprise you've experienced so far in life?
Sky Diving
Name three things you can't travel without.
My Phone, my Headset, my Friends
Where is your favourite place to escape?
Lac de Vouglans , Jura, France
What was the best advice you were ever given?
Leave the negative behind you
Attending NamesCon Global 2019? We want to give conference attendees the opportunity to learn more about you before the show! Fill out the Featured Attendee Profile form here.

subset: commoncrawl


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more photos
Zdrelac is the place on Pasman, one of the islands of the Zadar Archipelago connected by ferry line with Biograd. It is called by the narrow passage Ždrilo (ždrilo=gorge) at whose end it is situated. Zdrelac lies at the crossroads of maritime routes for the excursions to the nearby islands and the Kornati Archipelago. It is an attractive assigned point for boaters and lovers of water sports.
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Tag Archives: Fran Carter Make Up Sussex
A Rustic, Rural and Romantic Sussex Barn Wedding ~ Anna & Chris
Stop whatever you are doing (apart from reading this, of course) and just take a minute to appreciate the prettiness that is Anna and Chris' beautiful Hendall Manor Barns big day! Still with us? Good. This gorgeous couple tied the knot on a bright and blustery October day last autumn; … [CLICK TO READ MORE]
Posted in Country Weddings Sussex, East Sussex Wedding, Real Weddings Tagged Cheese wedding cake Sussex, Disco Fever DJ, Fran Carter Make Up Sussex, Hayley Rose wedding photography, Hendall Barns Wedding, Justin Alexander wedding dress, Rustic barn wedding Sussex, Sussex barn wedding, The Secret Restaurant 2 Comments


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St. Monica School Workshop fundraiser!
Posted by Sheena Monahan on
We had a wonderful time raising money for the Lovely St. Monica School in Whitefish Bay WI ! Loved all the elbow room we had in Donovan Hall!
Thank you for supporting your school !!!
For fundraising opportunities like this one please contact us!


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Naomi de Bruyn penned this review.
I was looking forward to reviewing this CD with an anticipation I usually reserve for live gigs. The reason — a carynx is actually played on it! And I've wanted to hear this elusive instrument ever since I was told how wild and almost frightening it sounds. Rather like a banshee's wail, only deeper, it makes the hair stand up on the back of the neck rather nicely. The carynx is a 2000-year-old Celtic war horn, and if there's any Celtic in you, you'll feel the call. I swear it's a genetic thing, really. This particular carynx is extremely special, for according to the liner notes, it is the only playable one in existence. It is made of bronze, and comes complete with a wild boar's head, with gaping mouth and lolling tongue. The craftsmanship is just incredible, and the sound which comes forth is indeed haunting. And if one were a foe, it would give pause for thought, so chilling is its call.
For those of you not familiar with Kathryn Tickell, she is an ultimate listening delight. Kathryn is an accomplished piper and fiddler. She comes from Northumberland, which is one of England's largest counties, and has put out a number of CDs. Kathryn actually picked up the Northumberland pipes at the age of nine for the first time, and I'm happy to say she didn't put them back down but kept at it. Kathryn has appeared on four of Sting's albums, including Fields of Gold. She has also worked with the likes of Maddy Prior, Nick Holland, and Troy Donockley.
Ensemble Mystical is a journey, from the new original pieces to the oldest of the traditional airs. There is magic on this disc, the magic of incredible talents joined with one another and playing music which weaves about the soul like sunlit vines, complete with the occasional shadows within which to delve. This disc is an experience on many levels, not just for the ears. It calls forth bubbling joy, tears of anguish, fear, and hope.
Joining Kathryn for the "journey" is Mary Macmaster (harp, vocals), Ron Shaw (cello), Julian Sutton (melodeon), John Kenny (trombone, sackbut, alphorn, recorder, carynx), and of course Kathryn Tickell herself (Northumbrian pipes, fiddle, vocals), and also joining them are Allan Wood (vocals), and Donald Hay (percussion). Together, this is a very heady mix!
"Border Widow's Lament" is a touching, although very short, ballad from the Borders. It is a song of grief, and it really pulls on the heart. The melody is dark and painful, and Mary's vocals hold all the anguish a woman could feel in that predicament. "He slew my knight/I watched his body night and day/I digged a grave a laid him in … " You cannot listen to this and remain without emotion.
My favourite, perhaps because of the carynx, is "The Burning Babe." According to the liner notes, the words are supplied by the English poet and martyr Robert Southwell (1561-1595). Mary supplies the main vocals, and Kathryn the additional vocals. Their voices twine about one another like living things, ending all too quickly.
There are two versions of "Corn Fiddler," and with good reason. In the first version it is a song; Kathryn supplies the vocals. According to the liner notes, Northumbrian poet Allan Wood wrote this as "a lilt to keep step with while sowing the land with seed." A corn fiddle was an old agricultural device for sowing seed and grain. It was so-called due to the motion one had to use to work it, somewhat similar to that of drawing a bow over the strings of a fiddle. In the second version, the words are spoken by Allan Wood, to the accompaniment of fiddles. This was done to preserve the dialect poetry which is a strong and living tradition in Northumberland, and Kathryn and Mary both felt they could not do justice to the Coquetdale accent. Both versions are lovely, but I prefer the second for it seems to evoke more imagery.
This is going to be a prized CD in my personal collection, to be listened to again and again, for Kathryn Tickell is a magical musician who will take me on journey after journey with her talent.
(Park Records, 2000)
About Diverse Voices
Diverse Voices is our catch-all for writers and other staffers who did but a few reviews or other writings for us. They are credited at the beginning of the actual writing if we know who they are which we don't always.
It also includes material by writers that first appeared in the Sleeping Hedgehog, our in-house newsletter for staff and readers here. Some material is drawn from Folk Tales, Mostly Folk and Roots & Branches, three other publications we've done down the years.


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03 December 2015
Day 37 / 105 - Foot Locker Cross Country Championships -- South Regional
On Saturday, our son raced in the South Regional of the Foot Locker Cross Country Championship.
We became aware of the race about five weeks ago. Competing in the South Regional are cross country runners from Alabama, Arkansas, Florida, Georgia, Kentucky, Louisiana, Mississippi, North Carolina, Oklahoma, Puerto Rico, South Carolina, Tennessee, Texas, Virginia, West Virginia, and the U.S. Virgin Islands. However, the race is held annually in Charlotte, on a course that is practically in our backyard. For that reason, our son was encouraged by his coach (and us) to run.
Since he's 14, he needed to run a 5K. He only ran one other 5K road race this season with a time of 22:10. His goal was not to win this race. Some of the fastest runners in the nation were present. His goal was to beat his previous 5K time and hopefully clock in when there was still a 20 on the clock.
He worked harder for this than I've ever seen him work. Even though the season was over, his coach kept an abbreviated practice schedule during the week. On the weekends, my son spent his Saturdays running sprint intervals, and he spent his Sundays running the race course twice. One of the aspects I love about running is that an athlete is always able to train to beat their own personal goals. Fortunately, he's seeing the results of that.
He finished the 5K course in 20:28. It was a great weekend for him!
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Rovers boss Lambert impressed with Koita
Blackburn Rovers boss Paul Lambert was impressed with Fode Koita's first start in their goalless draw at home to Nottingham Forest.
The Guinean missed the best chance of the game, which would have been enough to win the home side the match, but the former Aston Villa boss was left impressed.
"It's been tough for him to come in from another country and have to adjust quickly to a different style of football," Lambert told the Lancashire Telegraph.
"But I thought he was a handful all night; a real, real handful.
"He won a lot of headers, his physical presence was really strong and he had the best chance of the game.
"Probably if he would have mis-headed it, it would have gone in, but he was in there to head it, and I was delighted with the way he played."
Koita has made 11 Championship appearances for Rovers, having joined the club from French side Caen back in July.
"Fode's done well in training." Lambert added.
"He's unpredictable. You see him do things in training that make you think, 'he's got something here', and then there are other times when he makes little mistakes, which is fine.
"But I thought his performance was very good."


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Project Description
Jennie E. Rogers
Of Counsel
Phone: 404-365-4576
Fax: 404-364-3138
Jennie E. Rogers is Of Counsel with McLain & Merritt and has been practicing with the firm since 2016. Prior to joining the firm, Ms. Rogers was Claims Counsel in 2004 and then in 2013, the Managing Attorney for the Atlanta Staff Counsel office for American International Group, Inc. As Claims Counsel, she specialized in coverage matters arising out of the Trucking, Environmental, General Liability and Garagekeepers policies, bad faith claims, and litigation issues in North America and Canada. As Managing Attorney, Ms. Rogers headed up a litigation team handling tort litigation on behalf of self-insureds and insureds with an emphasis on premises liability, trucking liability, products liability litigation and workers' compensation matters. Ms. Rogers represents some of the nation's largest retailers and liability insurers in federal and state courts throughout Georgia. She has extensive trial and appellate experience.
Ms. Rogers is admitted to practice in the Eleventh Circuit Court of Appeals, United States District Court for the Northern District of Georgia, United States District Court for the Middle District of Georgia, and all Georgia appellate and trial courts. She received a B.A. in History and a J.D. from the College of William and Mary in Virginia. She served as Chief Justice of the Moot Court Board. Ms. Rogers is a member of the State Bar of Georgia, the State Bar of Virginia, and the Atlanta Bar Association.
- The College of William and Mary in Virginia, Marshall-Wythe School of Law, J.D., 1981, Chief Justice and Member, Moot Court Board, 1979-1981
- The College of William and Mary in Virginia, B.A. History, 1978
- U. S. Court of Appeals, 11th Circuit
- U. S. District Court, Northern District of Georgia
- U. S. District Court, Middle District of Georgia
- Supreme Court of Georgia
- Court of Appeals of Georgia
- Supreme Court of Virginia
- Court of Appeals of Virginia
- State Bar of Georgia
- State Bar of Virginia
- Atlanta Bar Association


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Real Gangster City Crime Vegas 3D
Pop-Pop Candies play game in the Kizi 1000 site
Kizi1000.in is a great place to play the best free online Kizi games
Enjoy a sweet puzzle as you pop-pop all the candies using strategy and fast reflexes! Featuring 100+ challenging puzzles and marathon endurance levels this colorful Match-3 Puzzle Shooter game will entertain for hours.
Play the best free online Kizi games, from the top game developers all over the world. Play free online at Kizi1000.in.
Game loading!


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Anthea Terlegas
Anthea is a dually-qualified lawyer, whose expertise focuses on the areas of banking and finance, project finance and energy. She has extensive experience in advising both lenders and borrowers on the structuring, documentation and negotiation of complex secured financings in the energy, infrastructure and real estate fields, as well as in the context of large debt restructurings and secondary debt trades using the LMA platform.
"Practicing banking & finance law involves being exposed to a wide variety of transactions, in the context of which it is necessary to have a thorough understanding of each transaction's structure, as well as to address ad-hoc commercial issues in a swift, practical and cost-efficient manner. This aspect of my career is both challenging and motivating and simultaneously enhances market awareness in general. The firm's positive working environment, its continuous support and its emphasis on maintaining the delivery of high-quality, client-oriented work are the key reasons I joined, and remain a member of, the firm."
AdmissionsAthens, 2011
Solicitor of England and Wales, 2009
EducationCollege of Law Postgraduate Diploma in Legal Practice, 2007
University of Warwick LLB, 2006


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Public Workshop to be held on Wednesday, September 7
PROVIDENCE, R.I. � The Rhode Island Department of Environmental Management (DEM) announced today a second public workshop on the State's new Farmland Acquisition Program (FAP). FAP, approved by voters as part of a 2014 environmental bond measure, helps ensure Rhode Island's farmlands remain in farming. During the workshop, DEM will highlight and gather input on a preliminary outline of the FAP program.
WHAT: Review and Comment on Draft Rules & Regulations for the Rhode Island Farmland Acquisition Program
WHEN: Wednesday, September 7, 2016 � 5:30 p.m.
WHERE: Corless Auditorium, URI Graduate School of Oceanography 215 South Ferry Road, Narragansett
DEM continues to work across many fronts to strengthen Rhode Island's green economy and to promote the viability of local agriculture. The state's green industries account for more than 15,000 jobs and contribute $2.5 billion to the economy each year. And local agriculture continues to be a hotbed for innovation and entrepreneurship � with the number of farms in Rhode Island on the rise and a growing young farmer network. Access to land, however, continues to be a challenge for many farmers. FAP is one way DEM is addressing this challenge. It allows the Department to partner with the State's Agricultural Land Preservation Commission and willing sellers to purchase farmland, protect it, and affordably sell it to farmers looking for land. The voluntary program supports farmers by giving landowners an option that will keep historic farmlands available for farming. As part of the 2014 Clean Water, Open Space and Healthy Communities bond measure, $3 million is available for farmland preservation. The Draft FAP Rules & Regulations are available online and will be updated based on public input.
For more information on DEM programs and initiatives, visitwww.dem.ri.gov. Follow us on Facebook at www.facebook.com/RhodeIslandDEM or on Twitter (@RhodeIslandDEM) for timely updates.


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A film about (local) patriotism, tourism and emigration.
The girl lives in a gray, isolated country, enclosed by a huge wall. She has never travelled anywhere, but all her life she has dreamt of leaving forever for a perfect world called "Abroad".
Production: FILM HOUSE BAŠ ČELIK
In Coproduction with: Your Dreams Factory and BFILM
Stop motion animation, 9'20''
Ana Nedeljković was born in Belgrade in 1978. She graduated in painting from the Faculty of Fine Arts in Belgrade. She was awarded a PhD in art practice at the same faculty. She is a visual artist working in the media of drawing, installation and animated film, and is also active in art education. www.ananedeljkovic.com
Nikola Majdak Jr. was born in Slovenia in 1972. He has an MFA from the Faculty of Dramatic Arts in Belgrade, camera department. For the past 20 years he has been a freelance cameraman, animator, director and lecturer.
Their first film "Rabbitland" (2013) was awarded the Crystal Bear at the Berlinale. It has also received numerous other awards and has been shown at more than a hundred festivals worldwide.


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Dermatologist explains why Exilis leads as a popular fat melting treatment
Not fitting into our favorite pair of jeans or swimsuits can leave us feeling down. Fortunately, a fat-melting treatment can be the ideal solution when dieting and exercising have been unsuccessful. This unwanted fat can be on the abdomen, thighs, arms, legs, face, and neck. The popular and innovative treatment is called Exilis, which can also treat "love handles," the upper back, male breasts, knees, ankles, and buttocks. Tightening certain areas of the body can renew confidence and help you fit into your favorite pair of skinny jeans as well as look and feel more beautiful in a bikini.
Seeking the expertise of a nationally prominent dermatologist
Regardless of your reason for exploring Exilis, Dr. Jeanine Downie is happy to explain what can be expected throughout treatment. Dr. Downie, the founder of image Dermatology® in Montclair, is a nationally known board-certified dermatologist who makes frequent appearances on shows including The Today Show and Dr. Oz. Dr. Downie can personally attest to results from Exilis, she saw a significant improvement after treating her own "love handles." Exilis is a skin tightening and tissue melting treatment for all skin tones, making it an excellent solution for many patients.
to book an appointment today.
What can be expected throughout treatment
During a consultation appointment, we will examine the areas you wish to have treated, review your medical history, ask you about your goals, and devise a treatment plan. We typically recommend four to six sessions over a few months for optimal results. A session is typically less than an hour and can be scheduled during a lunch break. There is no downtime, allowing you to return to work or other daily activities after a session.
The treatment areas are covered with a protective gel before the procedure. We will use a handheld device that reaches tissues under the skin with thermal energy. You may experience a warming sensation; however, we can activate a cooling system to keep the surface of the skin comfortable. Patients compare treatment to a hot stone massage. Following treatment, we recommend drinking at least 10 glasses of water the day before, and after the procedure.
Do you want to learn more about this fat melting, body contouring, and skin tightening treatment? Dr. Downie would love to meet with you during a consultation. Schedule yours by calling +1 (973) 509-6900.Back to Fat Melting Page


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The Canal Landing
— Deny's Trading Post —
— The Heart of Mi'kmaki —
— Welcome to The Canal Landing —
— Welcome to The Canal Landing —
— What you get here —
— What you get here —
Come visit us at the Canal Landing, where the ocean meets the inland sea.
Located on a National Historic site, The Canal Landing was once the former home of Nicholas Deny's Trading Post, a place where early settlers would trade with the Mi'kmaw. The Canal Landing is a recently established retail tourism hub that offers experiences that are culturally orientated, has recreational equipment rentals and a place to purchase authentic high quality crafts.
We will be serving food such as:
- Hamburgers
- Hot dogs
- Lobster
- Canteen
- & More!
The activities that canal landing will offer include:
- Kayaking
- Canoeing
- Hobie Mirage Eclipse Standup Board
- Pedal Boating
- Traditional Medicine Displays
- Sweet Grass Excursions
- Bicycle Rentals
- Fishing Equipment Rentals
The types of services that canal landing is providing this summer are:
• Sweet Grass Tours
• Medicine Walks
• Retail Products
• Dining Services


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Nearly everyone is interested in self-improvement. Especially when it comes to the way we look. For a lot of people, plastic surgery is a preferred method of enhancing their appearance. If you are thinking about this option, the following article will help educate you on the topic with smart advice, and helpful tips.
To ensure your cosmetic procedure is being being done by a trained professional, research the doctor's background. Learn where they were educated. What kinds of licenses, and certifications they have. Any extra training they may have undergone, and if there are any records of them with your local Department of Health. Also, ask the doctor how many times they've done the procedure you want.
When contemplating cosmetic procedures requiring surgery, it is wise to request a fair number of before and after photographs prior to scheduling your operation. By assessing the true potential as well as the limitations of your chosen procedure, you will head into the process with realistic expectations of what is achievable, thereby avoiding possible disappointment.
You should be very cautious in selecting your cosmetic surgeon. You should talk to friends and people in your community. You should look up your surgeon online and read reviews of former patients. It is imperative that you have trust in your surgeon in order have good cosmetic surgical experience.
Prior to your plastic surgery procedure, you will want to make a point to go and check out the surgery center. You can also research the center online to ensure that it is licensed, inspected or accredited. This is one of the most important pre-surgery steps you can take to ensure that your surgery is safe.
There are a lot of benefits to be had from plastic surgery; one is higher self-esteem. For example, a person who has suffered a burn generally can greatly benefit from plastic surgery. When a person has suffered a severe burn, he or she no longer feels whole; therefore, cosmetic surgery is normally called for to improve the person's self esteem.
Do not allow your child to get cosmetic surgery if they are not old enough to sign the consent forms themselves. You should let your child wait until they are fully developed both mentally and physically. Once they are of age, you can support them in whatever they choose to do.
If your teenager is asking for plastic surgery, you should wait until he or she is done growing and is mature enough to make an educated decision. Offering the child the opportunity to alter their appearance can be good for their self-esteem, but keep in mind that their body will probably keep changing after the surgery.
Take the time to save up some money if you need to. You should never settle for a cheaper alternative if this solution is riskier or if the surgeon is not properly qualified. If you want a surgery, pay the full price and look for quality rather than savings.
To summarize, it is important that you read all the information provided here about plastic surgery and use it. Be sure to pay attention to all of the details provided and check with your doctor if there is anything that you are unsure about. Hopefully, this provided beneficial information to you.


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I think in metaphors. Or symbols. On good days – puns. Lately I've been getting into cooking. Actual cooking, not reheating frozen veggie burgers. Quinoa, salmon, halibut, sautéed mushrooms, actually using the spices I have beyond salt. Not only have I felt better physically, but the response from my friends has been so overwhelmingly positive, I almost don't believe them…almost.
It's true, you are what you eat. And setting the conscious intention of preparing quality healthy food that I let into my body has made a big difference in how I feel physically. Which made me think about what I'm unconsciously letting in mentally or emotionally and how THAT is making me feel.
Everyone knows we live in an obscenely saturated media culture, which is compounded when we live in urban settings because we have to block so much of our environment out to survive the day. (This is no exaggeration. Can you imagine being open to all the energy of the people, cars, vendors and happenings while driving at the corner of Hollywood and Highland? Just that corner alone would paralyzed us and we'd die.) The effects of blocking out all this energetic information narrows the view point and without clarity or focus, I want to know what enters that precious frame and why?
The big city can be lonely. It's lonely to live in any environment where you have to block so much of it out. When we're lonely, we're vulnerable. Perfect time for other people's opinions or quick fixes tend to make their way into our purview – ie Social media and the expertise of those in 'authority.' That's where discernment comes in.
Discernment: The ability to obtain sharp perceptions or to judge well.
Back to our food analogy for a moment: it's easy for me to discern between fast food and a delicious meal I'm making at home. McDonald's was my jam growing up, but it's nowhere near my radar today. #winning. I want to develop that same sharp discernment when it comes to the opinions of others.
This past week, a colleague of mine told me that the industry never promised me a career, very soon I will be aged out of the majority of paying roles and I should try another career before working off the card. This was a response to a discussion we were having about the state of the commercial world and the growing non-union work. That statement was combination punch to the heart, gut and ovaries. Perfect opportunity for discernment –Is he an expert? Is he an expert on the trajectory of my personal career?* No. He's an expert on his opinion. Therefore, I cannot let it in and override my intuition and desire. By the way, there is no one expert in this business. There is no one expert. That fact is equally frustrating and freeing.
So! Like fast food – avoid that thinking and opinion entirely. Fast food makes me feel awful. And defeatist attitudes induce the same nausea with a side of rage. I cannot allow either in my body. And neither should you.
It's a delicate balance between inner instinct and environmental influence. It's hard to hear things we don't want to hear. Discernment is a way to determine if the uncomfortable is healthy growth (like learning to appreciate kale) or hogwash, bullshit and a waste of mental energy (candy crush)
I wish this article outlined how to do discern. I'm a beginner. It's something that is cultivated over time. The best I can do is share my journey with it so far. In the sharing, I hope a collective resonance will unite us. At best, it's food for thought. (It's not a pun, but I'll take a metaphor any day.
About Katie Wallack
Katie Wallack is a professional actress and active union member. She serves on SAG-AFTRA's Commercial Performers Committee and Commercials Contract Standing Committee, and partnered with the grass roots group Union Working. Katie began graduate school in 2017 at Claremont Lincoln University pursuing a Masters Degree in Ethical Leadership. She received numerous scholarships including the John L. Dales Scholarship from SAG-AFTRA Foundation. Her undergrad degree is in Theater and Dance from Trinity College. Katie's recent film projects include "Mum" for Shoot 'Em Up show, "Stillwater", and "Wight Christmas" shot on location in her hometown – Anchorage Alaska. In addition to her theatrical credits, she has been seen in numerous commercial campaigns over the years, including McDonald's and Ford Service.


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- Message From the Chair
- Letter from the Editor
- Awards and Scholarships
- Interview
- Technical Program
- Informatics and Chemical Biology: Identifying Targets and Biological Pathways
- Collaborating for Success: Professional Skills Development for Undergraduates, Graduates, and Post-Docs
- What do synthetic chemists want from their reaction systems?
- Herman Skolnik Award Symposium
- Tim Clark: Approaching reality - simulating electronic devices
- Alex Tropsha: Applications of machine learning to materials and chemical property prediction
- Yoram Cohen: A nanoinformatics platform for environmental impact assessment of manufactured nanomaterials
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David Winkler: Sparse QSAR modeling methods for therapeutic and regenerative medicine
David Winkler's award address was co-authored by his colleague Frank Burden, now retired from CSIRO, and by co-workers at Imperial College London, King's College London, and the University of Nottingham, whose work is acknowledged in the literature references.
David's research concerns computational chemistry applied to a molecular level understanding of interactions of molecules and materials with biology. He has a strong interdisciplinary, translational research focus. His modeling, design, and optimization of bioactive materials focus on testing model predictions by subsequent experiments. He employs a range of computational tools including quantum chemistry, molecular dynamics and mechanics, molecular graphics, pharmacophore models, protein docking, and, in the case of this talk, quantitative structure-property relationship modeling. He is interested in the design of drugs and materials for therapeutic and regenerative medicine, especially control of stem cell fate, with a particular focus on the application of artificial intelligence (AI), machine learning, pattern recognition, complex systems science, evolutionary algorithms, and adaptive learning.
His work has had commercial impact, including the transfer of neural network modeling technology to BioRAD Corporation; several field trials candidates with Du Pont and Schering Plough; and clinical trials of a radioprotectant drug for cancer radiotherapy patients (with Sirtex and the Peter Mac Cancer Institute). He developed core intellectual property (a novel antibacterial target in bacterial replisome) for the Betabiotics company spinoff, and discovered a new mechanism for strontium biomaterial-induced differentiation of mesenchymal stem cells to bone. He carried out a large project with Air Liquide Santé on using in silico methods to understand the surprisingly rich biological properties of noble gases. He discovered new antifibrotic and antihypertensive agents for Vectus Biosystems (allowing them to float on the stock market) and a first in class drug lead for myelofibrosis, which will be further developed by a new spin off company soon.
Winkler's research thinking was greatly influenced by complex systems science, which finds deep mechanistic similarities between areas of science that appear to have nothing in common. Concepts include nonlinear dynamical behavior, networks and their attractor states, self-organized criticality, chaos, and emergent properties. Complex systems science stimulates substantial lateral thinking and novel problem solving. Methods from other areas of science can provide novel solutions to problems in drug discovery; and methods developed for drug discovery can provide novel solutions to problems in other areas of science, such as biomaterials, gene expression, non-biological materials, and regenerative medicine.
QSAR was invented by Toshio Fujita (very recently deceased) and Corwin Hansch, and rapidly evolved into a method for optimization of drugs and agrochemicals. David and Toshio published a recent paper43 on the two forms of QSAR: "explain" and "predict". Graham Richards' and Peter Andrews' seminal commercialization ventures influenced David to make translation a strong focus in his research.
The research for which David received the Skolnik award involved the application of modern computational and mathematical methods to optimizing the QSAR modeling process.44 The first operation is to generate descriptors. Model quality is critically dependent on descriptors. Descriptors with low or no relevance to the property modeled degrade the model. Bad descriptors were a problem in early QSAR work, and there is still a major research need for good descriptors for materials. Next a subset of descriptors is chosen for the model in a context-dependent way. Choosing too many subsets can give chance correlations. In generating the relationship between the descriptors and the target property, model quality is less dependent on the modeling algorithm than on the descriptors, but there can be issues in overfitting, overtraining, ambiguity in network architecture, and subjective choices. The next operation is validating the performance of the model in predicting properties of new data. Here, cross validation and bootstrapping generate optimistic measures of performance, and an independent test set not used in training is best. The final operation is making new predictions from the model and synthesizing and testing new materials.
Descriptors are the last major research problem for QSAR. Many (such as DRAGON descriptors) are arcane; efficient, interpretable descriptors are needed. Descriptors specific to complex materials are essential, but the field is embryonic. High throughput characterization data can augment computed descriptors.
There are advantages in removing irrelevant features. Least squares in multiple linear regression (MLR) has a Gaussian prior. This can be replaced with a Laplacian prior which effects the removal of uninformative weights by driving them to zero. Sparse Bayesian feature selection methods (feature selection using expectation maximization) identify a small number of relevant features very efficiently.45
There are many methods of varying sophistication in finding structure-activity relationships,44 including simple linear statistical regression methods such as multiple linear regression; nonlinear regression methods using polynomials or nonlinear kernels, and nonlinear machine learning; bioinspired methods such as neural nets; support vector machines; and random forests. These have new applications in materials, nanotechnology, and regenerative medicine.
The universal approximation theorem states that neural networks can model any complex relationship given sufficient training data. Neural networks are very well suited to modeling of complex data, but they have problems such as overfitting and overtraining. They raise an ill-posed problem in statistics (instability), and optimum network architecture is ambiguous. The contribution of David and his co-workers is to develop very robust, self-optimizing sparse feature selection and neural network methods that overcome all these problems.46 These methods have been shown to have performance similar to that of deep neural networks.
Sparse Bayesian modeling and feature selection, replacing the Gaussian prior with the Laplacian prior, is a general nonlinear modeling method45,47-49 that automatically optimizes model complexity, prunes neural network weights to avoid overfitting, and prunes irrelevant descriptors to optimize the predictivity of a model. A sparsity-inducing Laplacian prior (LP) was introduced into Winkler's Bayesian Regularized Artificial Neural Network algorithm (BRANN) creating BRANNLP.47,49 Low relevance weights are set to zero, and descriptors are also pruned from the model if all weights are zero.
From selection and mapping, David turned to validation. Cross validation, bootstrapping, and other methods give an overly optimistic estimate of predictive power because the test set is not independent of the training set. An independent test set never seen by the model is the gold standard. Many measures of predictivity have been proposed. Test set validation is actually a simple problem in statistics; standard error of prediction, test set (SEP) is preferred over r2 as it is less dependent on dataset size and model complexity.46,50
Methods from other areas of science can provide novel solutions to problems in drug discovery, and methods developed for drug discovery can provide novel solutions to problems in other areas of science. Implantable medical devices are an example. Bacterial adhesion and growth on biomaterial surfaces of joint prostheses, heart valves, shunts, vascular and urinary catheters, and intraocular lenses are serious problems in health care. There is a major unmet medical need for new coating materials for implantable and indwelling medical devices. David and his co-workers from Morgan Alexander's research team at the University of Nottingham have used machine learning methods to derive quantitative models relating the molecular structure of a polymer to the attachment of the bacteria to that polymer surface. These models can be used to screen large databases of new materials for those with low pathogen attachment.
Hook et al. have detected the attachment of selected bacterial species to 576 polymeric materials in a high-throughput microarray format.51 In work by David and his colleagues, data from a large polymer microarray exposed to three clinical pathogens were used to derive robust and predictive machine learning models of pathogen attachment.52 The BRANN models can predict pathogen attachment for the polymer library quantitatively. The models also successfully predict pathogen attachment for a second-generation library, and identify polymer surface chemistries that enhance or diminish pathogen attachment. A manuscript on work on multiple pathogen attachment models has been submitted.
Sparse feature selection methods have also identified a new mechanism for strontium biomaterial-induced differentiation of mesenchymal stem cells to bone. Strontium ranelate (Protelos) is a drug approved in the European Union for the treatment and prevention of osteoporosis. It reduces risk of vertebral and non-vertebral fractures in post-menopausal women. Although controversial, it is reported to have an anabolic and anti-catabolic effect on bone. Strontium ion's mechanism of action is not fully understood, but it is thought to up-regulate differentiation of osteoprogenitors or stimulate bone formation.53-55
David and his Imperial College co-workers,56 Molly Stevens, Eileen Gentleman, and Hélene Autefage, have evaluated the global response of human mesenchymal stem cells to strontium-substituted bioactive glasses using a combination of unsupervised biological and physical science techniques. Their objective analyses of whole gene-expression profiles, confirmed by standard molecular biology techniques, revealed that strontium-substituted bioactive glasses up-regulated the isoprenoid pathway, suggesting an influence on both sterol metabolite synthesis and protein prenylation processes.
In future, David hopes to see exploitation of new AI methods such as deep learning; improved descriptors for molecules that are effective and interpretable; exploitation of evolutionary methods of discovery aided by robotics; synergy of AI and evolutionary methods for adaptive evolution; adoption of in silico methods from drug discovery for materials and regeneration; development of autonomous or semiautonomous "closed loop" design methods; and more effective exploration of vast molecular or materials spaces.
Deep learning was predicted to be a breakthrough technology in 2013. Deep neural networks are not necessarily magic. According to the universal approximation theorem, a feed-forward network with a single hidden layer containing a finite number of neurons can approximate any continuous function, under mild assumptions on the activation function. This was first proved by Cybenko in 1989 for sigmoid activation functions. Hornik showed in 1991 that it is not the choice of the activation function, but the multilayer architecture itself which gives neural networks the potential of universal approximators.46
Deep learning methods have generated impressive improvements in image and voice recognition, and are now being applied to QSAR and QSAR modeling. A recent publication46 describes the differences in approach between deep and shallow neural networks, compares their abilities to predict the properties of test sets for 15 large drug datasets, discusses the results in terms of the universal approximation theorem for neural networks, and describes how deep neural networks may ameliorate or remove troublesome "activity cliffs" in QSAR datasets. Materials space is vast and at least in some of its many dimensions, the fitness landscape is smooth. This allows adaptation, one step (one mutation) at a time. Evolution and machine learning can be combined in adaptive learning (the Baldwin effect).
A recent review discusses the problems of large materials spaces, the types of evolutionary algorithms employed to identify or optimize materials, and how materials can be represented mathematically as genomes.57 It describes fitness landscapes and mutation operators commonly employed in materials evolution, and provides a comprehensive summary of published research on the use of evolutionary methods to generate new catalysts, phosphors, and a range of other materials. Another recent paper describes the materials genome in action.58
Machine learning methods have achieved wide applicability: for example, in aqueous solubility of drugs;59 polymers for stem cell growth;60 cubane as a benzene isostere;61 benign organic corrosion inhibitors;62 markers for stem cell division;63 materials for stem cell factories;64 adverse effects of nanomaterials;65 anticancer farnesyltransferase inhibitors;66 and prediction of materials properties.44
In summary, AI tools developed for therapeutic medicine also work well for regenerative medicine. Neural networks are machine learning methods that are very applicable to (bio)materials design. The universal approximation theorem means that deep learning methods should not be superior to shallow neural networks for molecular design. Bayesian regularized neural networks can generate robust, predictive models of many types of materials and properties. Sparse Bayesian feature selection methods can reduce the dimensionality of problems, improve interpretability, and generate robust models with better predictivity. Evolutionary methods, combined with machine learning (adaptive evolution) can find effective materials quickly and efficiently.
Erin Davis, chair of the ACS Division of Chemical Information, formally presented the Herman Skolnik Award to David Winkler at a reception held in honor of David, following the symposium.
Erin Davis and David Winkler
- Fujita, T.; Winkler, D. A. Understanding the Roles of the "Two QSARs". J. Chem. Inf. Model. 2016, 56 (2), 269-274.
- Le, T.; Epa, V. C.; Burden, F. R.; Winkler, D. A. Quantitative Structure-Property Relationship Modeling of Diverse Materials Properties. Chem. Rev. (Washington, DC, U. S.) 2012, 112 (5), 2889-2919.
- Figueiredo, M. A. T. Adaptive sparseness for supervised learning. IEEE Trans. Pattern Anal. Mach. Intell. 2003, 25 (9), 1150-1159.
- Winkler, D. A.; Le, T. C. Performance of Deep and Shallow Neural Networks, the Universal Approximation Theorem, Activity Cliffs, and QSAR. Mol. Inf. 2017, 36 (1-2), 1600118.
- Burden, F. R.; Winkler, D. A. Robust QSAR models using Bayesian regularized neural networks. J. Med. Chem. 1999, 42 (16), 3183-3187.
- Burden, F. R.; Winkler, D. A. An Optimal Self-Pruning Neural Network and Nonlinear Descriptor Selection in QSAR. QSAR Comb. Sci. 2009, 28 (10), 1092-1097.
- Burden, F. R.; Winkler, D. A. Optimal sparse descriptor selection for QSAR using Bayesian methods. QSAR Comb. Sci. 2009, 28 (6-7), 645-653.
- Alexander, D. L. J.; Tropsha, A.; Winkler, D. A. Beware of R2: Simple, Unambiguous Assessment of the Prediction Accuracy of QSAR and QSPR Models. J. Chem. Inf. Model. 2015, 55 (7), 1316-1322.
- Hook, A. L.; Chang, C.-Y.; Yang, J.; Luckett, J.; Cockayne, A.; Atkinson, S.; Mei, Y.; Bayston, R.; Irvine, D. J.; Langer, R.; Anderson, D. G.; Williams, P.; Davies, M. C.; Alexander, M. R. Combinatorial discovery of polymers resistant to bacterial attachment. Nat. Biotechnol. 2012, 30 (9), 868-875.
- Epa, V. C.; Hook, A. L.; Chang, C.; Yang, J.; Langer, R.; Anderson, D. G.; Williams, P.; Davies, M. C.; Alexander, M. R.; Winkler, D. A. Modeling and prediction of bacterial attachment to polymers. Adv. Funct. Mater. 2014, 24 (14), 2085-2093.
- Reginster, J. Y.; Seeman, E.; De Vernejoul, M. C.; Adami, S.; Compston, J.; Phenekos, C.; Devogelaer, J. P.; Curiel, M. D.; Sawicki, A.; Goemaere, S.; Sorensen, O. H.; Felsenberg, D.; Meunier, P. J. Strontium Ranelate Reduces the Risk of Nonvertebral Fractures in Postmenopausal Women with Osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) Study. J. Clin. Endocrinol. Metab. 2005, 90 (5), 2816-2822.
- Meunier, P. J.; Roux, C.; Seeman, E.; Ortolani, S.; Badurski, J. E.; Spector, T. D.; Cannata, J.; Balogh, A.; Lemmel, E.-M.; Pors-Nielsen, S.; Rizzoli, R.; Genant, H. K.; Reginster, J.-Y.; Graham, J.; Ng, K. W.; Prince, R.; Prins, J.; Seeman, E.; Wark, J.; Reginster, J. Y.; Devogelaer, J. P.; Kaufman, J. M.; Raeman, F.; Ziekenhuis, J. P.; Walravens, M.; Pors-Nielson, S.; Beck-Nielsen, H.; Charles, P.; Sorensen, O. H.; Meunier, P. J.; Aquino, J. P.; Benhamou, C.; Blotman, F.; Bonidan, O.; Bourgeois, P.; De Vernejoul, M. C.; Dehais, J.; Fardellone, P.; Kahan, A.; Kuntz, J. L.; Marcelli, C.; Prost, A.; Vellas, B.; Weryha, G.; Lemmel, E. M.; Felsenberg, D.; Hensen, J.; Kruse, H. P.; Schmidt, W.; Semler, J.; Strucki, G.; Phenekos, C.; Balogh, A.; De Chatel, R.; Ortolani, S.; Adami, S.; Bianchi, G.; Brandi, M. L.; Cucinotta, D.; Fiore, C.; Gennari, C.; Isaia, G.; Luisetto, G.; Passariello, R.; Passeri, M.; Rovetta, G.; Tessari, L.; Badurski, J. E.; Hoszowski, K.; Lorenc, R. S.; Sawicki, A.; Diez, A.; Cannata, J. B.; Diaz Curiel, M.; Rapado, A.; Gijon, J.; Torrijos, A.; Padrino, J. M.; Roces Varela, A.; Bonjour, J. P.; Rizzoli, R.; Spector, T. D.; Clements, M.; Doyle, D. V.; Ryan, P.; Smith, I. G.; Smith, R. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N. Engl. J. Med. 2004, 350 (5), 459-468.
- Meunier, P. J. Postmenopausal osteoporosis and strontium ranelate. Reply. N. Engl. J. Med. 2004, 350 (19), 2002-2003.
- Autefage, H.; Gentleman, E.; Littmann, E.; Hedegaard, M. A. B.; Von Erlach, T.; O'Donnell, M.; Burden, F. R.; Winkler, D. A.; Stevens, M. M. Sparse feature selection methods identify unexpected global cellular response to strontium-containing materials. Proc. Natl. Acad. Sci. U. S. A. 2015, 112 (14), 4280-4285.
- Le, T. C.; Winkler, D. A. Discovery and Optimization of Materials Using Evolutionary Approaches. Chem. Rev. (Washington, DC, U. S.) 2016, 116 (10), 6107-6132.
- Thornton, A. W.; Simon, C. M.; Kim, J.; Kwon, O.; Deeg, K. S.; Konstas, K.; Pas, S. J.; Hill, M. R.; Winkler, D. A.; Haranczyk, M.; Smit, B. Materials Genome in Action: Identifying the Performance Limits of Physical Hydrogen Storage. Chem. Mater. 2017, 29 (7), 2844-2854.
- Salahinejad, M.; Le, T. C.; Winkler, D. A. Aqueous Solubility Prediction: Do Crystal Lattice Interactions Help? Mol. Pharm. 2013, 10 (7), 2757-2766.
- Epa, V. C.; Yang, J.; Mei, Y.; Hook, A. L.; Langer, R.; Anderson, D. G.; Davies, M. C.; Alexander, M. R.; Winkler, D. A. Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces. J. Mater. Chem. 2012, 22 (39), 20902-20906.
- Chalmers, B. A.; Xing, H.; Houston, S.; Clark, C.; Ghassabian, S.; Kuo, A.; Cao, B.; Reitsma, A.; Murray, C.-E. P.; Stok, J. E.; Boyle, G. M.; Pierce, C. J.; Littler, S. W.; Winkler, D. A.; Bernhardt, P. V.; Pasay, C.; De Voss, J. J.; McCarthy, J.; Parsons, P. G.; Walter, G. H.; Smith, M. T.; Cooper, H. M.; Nilsson, S. K.; Tsanaktsidis, J.; Savage, G. P.; Williams, C. M. Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere. Angew. Chem., Int. Ed. 2016, 55 (11), 3580-3585.
- Winkler, D. A.; Breedon, M.; Hughes, A. E.; Burden, F. R.; Barnard, A. S.; Harvey, T. G.; Cole, I. Towards chromate-free corrosion inhibitors: structure-property models for organic alternatives. Green Chem. 2014, 16 (6), 3349-3357.
- Huh, Y. H.; Noh, M.; Burden, F. R.; Chen, J. C.; Winkler, D. A.; Sherley, J. L. Sparse feature selection identifies H2A.Z as a novel, pattern-specific biomarker for asymmetrically self-renewing distributed stem cells. Stem Cell Res. 2015, 14 (2), 144-154.
- Celiz, A. D.; Smith, J. G. W.; Langer, R.; Anderson, D. G.; Winkler, D. A.; Barrett, D. A.; Davies, M. C.; Young, L. E.; Denning, C.; Alexander, M. R. Materials for stem cell factories of the future. Nat. Mater. 2014, 13 (6), 570-579.
- Epa, V. C.; Burden, F. R.; Tassa, C.; Weissleder, R.; Shaw, S.; Winkler, D. A. Modeling Biological Activities of Nanoparticles. Nano Lett. 2012, 12 (11), 5808-5812.
- Polley, M. J.; Winkler, D. A.; Burden, F. R. Broad-Based Quantitative Structure-Activity Relationship Modeling of Potency and Selectivity of Farnesyltransferase Inhibitors Using a Bayesian Regularized Neural Network. J. Med. Chem. 2004, 47 (25), 6230-6238.
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Code Match
Code match is such a simple problem. But it doesn't get much attention. And surprisingly, there aren't many ready-to-go code match solutions available. We have one—it's a new product for us and it's a winner.
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i'm searching for a solution you've described.
We have already Motorola Scanners with Windows CE 6.0 running.
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i'm searching for a solution you've described.
We have already Motorola Scanners with Windows CE 6.0 running.
Do you have a price list for the Software itself "ready to install" or an overwiev about your offers?
Thanks in advance
Viktor V.
What is the cost of each unit? What are the specs of the units (o/s, memory, etc)?
What is the cost of each unit? What are the specs of the units (o/s, memory, etc)?


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How many poems did Service write? Have they all been published?
It has been reported that Service wrote over 2,000 poems. Many to friends, relatives, and for special occasions. Only about 1,200 have been published. I understand there is a large collection of his work at the Mitchell Library in Glasgow.
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Ogun tops list of funded estates in Southwest, says FMBN – The Nation Newspaper. Doris Hill. Contents.. Fig 1.6: View of Consultants and Top Government Officials of Anambra State. Ogun State to form a mega city. southwest – northeasterly direction to reduce the effects..
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Editorial: California bill would help borrowers struggling with student debt Levine is campaigning on climate change. But his sea-rise legacy is complicated. The hottest city in the Twin cities metro area is. Blaine? | city pages affinity fcu partners with CU Realty Services to bring HomeAdvantage to New Jersey – CUInsight Loans – Affinity Plus Federal Credit Union – Get financing for new and used vehicles with an exclusive loan package, including warranty, loan protection, and a list of trusted dealer partners. home loans find first mortgages, home equity loans and other home loans for single-family homes, condos, townhomes, duplexes, cabins, rental homes, and more.Microsoft OneNote | The digital note-taking app for your. – Microsoft OneNote | The digital note-taking app for your.But his sea-rise legacy back home is complicated.. under Levine's tenure, angst about the city's climate change efforts effectively torpedoed.Editorial: California bill would help borrowers struggling with student debt. that 3.8 million student loan borrowers in California owe about $134.3 billion.. who were struggling with.
· Release everyone': Ocasio-Cortez says Paul Manafort's solitary confinement is government torture' Ogun tops list of funded estates in Southwest, says FMBN – The nation newspaper ogun State has the largest number of funded estates in the Southwest, the Managing Director, Federal Morgage Bank of Nigeria (FMBN), Ahmed Dangiwa, has said Dangiwa made this known at an.
Ogun tops list of funded estates in Southwest, says FMBN – The Nation Newspaper The Nation October 26,2011.. to enable the state expedite work on the completion of three housing estates being funded by FMBN in Zaria, Kafanchan and Barnawa.. says CBN. T. HE Central Bank.
Ogun tops list of funded estates in Southwest, says FMBN – The Nation Newspaper Prime Estates Developer begins Ogun Citygate estate Projects By Tosin Fodeke HE landscape of Agbara in Ogun state may be in for a major change as an indigenous property development firm, Messrs.
Job fair set at Fresno DoubleTree Hotel Convention Center An outdoor pool and a restaurant are featured at Fresno DoubleTree by Hilton Fresno Convention Center. Fresno Convention & Entertainment Center is a minutes' walk away. Free WiFi and free parking are included in all rooms. Styled in modern dcor, each room provides a flat-screen cable TV and free toiletries.Economists continue to pick holes in government programme US consumer credit for April $17.497 billion versus $13 billion estimate Read more about Microsoft tops $1 trillion after strong Q3 earnings, cloud growth forecast on Business Standard. per cent to $130.54 in late trading after the forecast issued on a conference call with investors, pushing the company ahead of Apple Inc's $980 billion.Deficit spending is the amount by which spending exceeds revenue over a particular period of time, also called simply deficit, or budget deficit; the opposite of budget surplus.The term may be applied to the budget of a government, private company, or individual. Government deficit spending is a central point of controversy in economics, as discussed below.Who Is Really Funding Uncle Sam? Uncle Sam, popular symbol for the United States, usually associated with a cartoon figure having long white hair and chin whiskers and dressed in a swallow-tailed coast, vest, tall hat, and striped trousers. His image is derived from two earlier symbolic figures in American folklore: Yankee Doodle and Brother Jonathan.Notes from the Publisher | FintekNews 'I am afraid': Taxi driver's sexual assault to result in deportation to India | CBC News April 2019 Price Paid data average propane Prices – NYSERDA – Average Propane Prices. Note: full service residential customers credit price, typically these accounts use annually 1,100 or more gallons of propane. Dealers are surveyed weekly from September through March; April through August, the survey is conducted twice a month.www.ebay.com – We would like to show you a description here but the site won't allow us.You've undoubtedly read here previously that you should own your ISBNs. Being the publisher of record for your books gives you complete.
Ogun tops list of funded estates in Southwest, says FMBN – The Nation Newspaper Ogun State has the largest number of funded estates in the Southwest, the Managing Director, Federal Morgage Bank of Nigeria (FMBN), Ahmed Dangiwa, has said Dangiwa made this known at an.


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Wendy Williams talks Sharina Hudson (00:10)
Wendy Williams talks 50 Cent on 'Watch What Happens: Live' (01:01)
Wendy Williams dating life (02:09)
Chance The Rapper postpones tour (03:34)
Blake Griffin roasts Kaitlyn Jenner (04:23)
Powerhouse on October 26th (05:50)
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Wendy Williams Says Very Nice Things About 50 Cent On 'Watch What Happens Live'
The Breakfast Club features celebrity interviews, Charlamagne tha God's Donkey of the Day, Angela Yee's Rumor Reports, DJ Envy's mixes and so much more! Every guest visiting the world's most dangerous morning show is grilled with their signature blend of honesty and humor. The results are the best interviews to be found on radio.
Mann Yee fine as hell
4:30 I'm sorry but those Blake Griffin jokes were funny! It's a ROAST, PC/Cancel Culture People!
Wendy Williams looking like a cougar out here😅 but I like cougars😂😂😅💯
Wendy want the D from 50
*This is no disrespect to Ms. Wendy Williams. Why does the breakfast club constantly report on her and her business?*
Wendy needa a train ran on her ugly ass, she talks to much…
Dick Gregory left his wife to march with Dr. King days after she had a miscarriage. She didnt like it. He was like oh well get over it the people need me. I wish someone had told those men your family needs you not the people. I want my man to go make his money not be up under me. I got aunties and grandma for that. You can see the baby when you get back. We got videochat homey!!!


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Environmental science is the study of the myriad interactions between us and the world.
As our population continues to grow, as technology advances and our needs and wants increase, our impacts on the world become more widespread and severe, despite improvement in some areas. Environmental impacts, in turn, affect human health and wellbeing.
Environmental challenges are multidisciplinary in nature. That is, in order to understand each environmental challenge sufficiently well to develop effective solutions, we must assemble expertise in several disciplines. It is also important that environmental scientists and decision makers understand the different sciences sufficiently well to communicate with those of other specialties and to appreciate the importance of other disciplines in addressing the challenges.
In the environmental science program, you will build a strong foundation in the basic sciences essential for understanding and resolving environmental challenges, including biology, chemistry, geology, physics and mathematics. You will enhance and apply this knowledge with experience in the field – from the highlands to the coast. You will work on a major research problem or gain professional experience by interning with a government agency, industry or consulting firm.
Upon completion of the environmental science program, you will be ready to start a meaningful and rewarding career as an environmental scientist, or begin graduate study, contributing to the rapidly growing body of knowledge in this multidisciplinary field.
Internships and Research in Environmental Science
Note: The information below provides convenient links to some of the courses required for this degree; however, it should not be used as a course registration guide. Please refer to the official Lander University Academic Catalog for the most accurate and up-to-date program requirements.
Humanities and Fine Arts
Behavioral and Social Perspectives
MATH 123 or MATH 141*
CHEM 381 or ES 390
1 For approved courses see the General Education section
2 Students are required to take at least one Global Issues and Cultures course prior to graduation
*Students anticipating graduate studies in environmental science are strongly encouraged to choose MATH 141.
Lander University offers a beautiful campus, modern residence halls, excellent academic programs and exciting sporting events. While to campus is closed due to the COVID-19 pandemic, we invite you to explore Lander virtually.
Welcome to Lander University! At Lander, you are our priority. As a member of a close-knit community that welcomes individual flair, you'll be known by name by peers and professors committed to your success. With study abroad experiences, intense and impactful research, more than 60 student organizations, performing arts and NCAA athletics, your Lander experience will launch you on a successful career and lifetime of learning.
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Students in Lander University's School of Nursing team up with the G. Frank Russell Technology Center to assemble "period packs," small packages containing feminine hygiene products, for young homeless women in local school districts.
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Lander's recent symposium on the South and World War I was a resounding success, drawing large audiences and attracting scholars from across the country, but it might never have happened without the publication of The American South and the Great War, 1914-1924, by Lander's Dr. Ryan Floyd, associate professor of history.
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Celebrating their fortieth reunion, the brothers of Kappa Sigma fraternity sold barbecue plates to tailgaters as part of Lander's 2020 Homecoming festivities on Saturday, Feb. 22. The funds raised from their cookout will support the Mary Kinard Able Scholarship fund.
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In this Aug 12, 2019 photo, thousands of protesters flooded Hong Kong International Airport, leading to the cancellation of all hundreds of flights for the rest of the day. (PHOTO / CHINA DAILY)
BEIJING - Radicalized protests and escalating violence in Hong Kong have weighed down the Asian financial hub and compromised the well-being of its 7 million residents.
Hong Kong International Airport is the latest to suffer. The airport, which normally handles nearly 200,000 passengers a day, has been disturbed by unauthorized protests, resulting in a large number of flights canceled.
IN PHOTOS: Travelers bear the brunt of protests as flights canceled again in HK
The illegal gathering also caused serious traffic jams along the expressways around the airport and affected the commutes of local residents.
Carrying weapons, smashing facilities, setting fires, blocking main streets and harassing passers-by, wherever the radicals have ventured, streets lie deserted, with shops closed and destruction in their wake. The scenes bear little resemblance to the dynamic and cosmopolitan Hong Kong of recent memory.
The damage has begun to show. Hong Kong's gross domestic product in the second quarter increased by only 0.6 percent in real terms year on year with the three sectors of catering, tourism and retailing hit the hardest.
Visitor arrivals and the hotel occupancy rate reported double-digit reductions in July and tourism business operators had their average revenue drop by almost 80 percent in the past two months year on year.
These scenes, so unbearable to anyone with love for Hong Kong, are exactly what the radicals and their behind-the-scenes string-pullers desire.
By taking a look at the regions around the world that underwent "color revolutions" instigated by Western forces, one sees case after case of civil war, social disorder, ethnic conflict and human suffering.
This cannot become the future of Hong Kong!
ALSO READ: Violence is pushing HK into 'abyss of destruction'
An increasing number of Hong Kong residents have broken their silence by standing against violence and voicing their support for the rule of law. They have expressed the Hong Kong people's common will that the chaos can last no longer.
It is the common aspiration of the Hong Kong people to stop violence and the chaos, so that Hong Kong can restore order and return to prosperity and harmony. Anyone who harms the city will surely be severely punished by law and condemned by the people.
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Solidarity day for al-Jazeera journalists held in Egypt
People in cities across the world have been staging protests in support of journalists from the al-Jazeera network who are being detained in Egypt.
Al-Jazeera has called for a "global day of action" to demand the immediate release of the journalists, who include former BBC correspondent Peter Greste.
Mr Greste and eight other al-Jazeera staff went on trial last week on charges including aiding a terrorist organisation - the Muslim Brotherhood.
Six are being tried in absentia.
Another 11 people are also defendants in the case, but al-Jazeera denies the prosecution's claim that they work for it.
It has said the allegations are "absurd, baseless and false" and denied aiding the Brotherhood, on which the authorities launched a fierce crackdown after the military ousted President Mohammed Morsi in July.
The interim government and its supporters have accused international news networks of bias in their reporting of the ongoing political crisis.
'Humiliation, threats and rage'
Thursday's global day of action saw dozens of journalists take part in demonstrations, holding up placards saying "journalism is not a crime". Some also taped their mouths shut.
They demanded the release of Mr Greste, an Australian al-Jazeera English reporter, as well as Egyptian-Canadian Cairo bureau chief Mohamed Fahmy, Egyptian producer Baher Mohamed and Egyptian al-Jazeera Arabic reporter Abdallah Elshamy.
The first three were seized in a raid at a Cairo hotel on 29 December, while Mr Elshamy was detained in the Egyptian capital on 14 August.
Mr Fahmy and Mr Mohamed are among 16 Egyptians charged with belonging to a terrorist organisation and "harming national unity".
Mr Greste and three other foreigners who have left the country - British al-Jazeera reporters Dominic Kane and Sue Turton, and the Dutch newspaper and radio journalist Rena Netjes - are accused of "collaborating with the Egyptians by providing them with money, equipment, information", and "airing false news".
Those present at the start of the trial pleaded not guilty to all charges.
Al-Jazeera cameraman Mohamed Badr was released last week after seven months in detention. On Thursday, he spoke of the difficulties he endured in prison until he was acquitted of separate charges.
"I faced humiliation, threats and rage, since the very moment of the arrest, when the officer threatened to kill me when he knew that I was al-Jazeera staff," he said.
"They took me then to some place they call 'the fire pit', where I was welcomed by severe beatings."
Mostafa Souag, acting director-general of al-Jazeera Media Network, said that the network was delighted to have Mr Badr back, but that it looked forward to the release of the rest of its journalists.
"Journalists and individuals have been speaking out in their thousands worldwide, not just in support of al-Jazeera, but because they know that this situation is a threat to freedom of journalists everywhere," he added.
Gehad Khaled, the wife of Mr Elshamy, said he had been detained without charge for 197 days, and that he had been on hunger strike for five weeks in protest.
"Despite what Abdallah is suffering, his message to all his colleagues is to stick to reporting the truth no matter the consequences," she added.


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- Home Secretary Theresa May says Syrians will face multiple screenings
- Two of the Paris gunmen arrived in Greece posing as refugee from Syria
- David Cameron is meeting world leaders at G20 summit in Turkey today
- The first Syrian refugees will arrive in Britain on charter flight this week
Britain is to step up security checks on Syrian refugees as they arrive this week over fears of terrorists sneaking into the country.
Home Secretary Theresa May said Syrians offered sanctuary in the UK would face multiple screenings as calls grew for Europe to tighten border controls after it emerged two of the Paris gunmen arrived in Greece posing as refugees from Syria.
David Cameron, who has vowed to destroy ISIS, is meeting world leaders at a G20 summit in Turkey but faces stiff opposition from Labour against Britain bombing jihadist strongholds in Syria.
Interviewed: Mrs May (left) said Syrians offered sanctuary in the UK would face multiple screenings, while Miss Bermann (right) said 'we have to strengthen our external borders'
PM: David Cameron, who has vowed to destroy ISIS, is meeting world leaders at a G20 summit in Turkey today (above) but faces stiff opposition from Labour against Britain bombing jihadist strongholds in Syria
On guard: French soldiers patrol at the Eiffel Tower which remained closed on the first of three days of national mourning in Paris today
The first Syrian refugees will arrive in Britain on a charter flight this week. The Government has offered to take 20,000 people by 2020 direct from camps in Syria and neighbouring countries.
But the UK has opted out of an EU scheme to relocate tens of thousands of people who have already reached Europe.
Public attitudes to the migration crisis are certain to harden in the wake of the Parisian atrocity which left more than 120 people dead and scores critically injured.
It will raise fears that ISIS could exploit the routes used by desperate refugees to carry out further attacks in Britain and the rest of Europe.
Mrs May insisted that touch procedures were in place to check the identity of those arriving in the UK.
French Ambassador to London Sylvie Bermann wept on TV this morning while listening to her country's national anthem – as she described the Paris attacks as her country's 9/11.
Emotional: Sylvie Bermann, French Ambassador to the UK, on the BBC's Andrew Marr Show today
Responding to the horrific attacks in which teams of gunmen killed 29 people in the French capital, she said it was an 'Act of War' and had been coordinated by Isis.
Miss Bermann, 61, then shed tears while listening to French opera singer Nicolas Courjal sing 'La Marseillaise' on the BBC's Andrew Marr Show this morning.
Tears: Miss Bermann listened to French opera singer Nicolas Courjal (left) sing 'La Marseillaise'
She said: 'I think this is totally different from Charlie Hebdo attacks. This time this is more like 9/11. This is an act of war.
'Those attacks have been coordinated, planned, organised from outside, from Isis.'
She told BBC1's Andrew Marr Show: 'We have processes in place. There are two levels of screening that take place.
'First of all, we are taking people directly from the camps. We are working with UNHCR - UNHCR take biometrics, they look at documents, they interview people, they do their own process of screening against issues like war crimes and serious criminality.
'Then there is a further check that is done once people are referred to the UK. The Home Office then undertakes further checks, further biometrics are taken.'
She added: 'We are ensuring that we are checking people who are coming in to the UK. Of course we are taking people direct from camps and that means we are taking some of the most vulnerable people.'
More than 700 Britons have travelled to Syria to join ISIS.
Up to 450 are thought to have returned to the UK, with security agencies tasked with monitoring them to see if they are plotting attacks.
'It is right that just over 700 have gone to Syria. Those who are returning, they are looked at on a case-by-case basis to see if action is necessary,' Mrs May said.
'Of course there may be some cases where it is possible to prosecute people who are coming back from Syria.'
France is calling for tighter controls on Europe's borders to prevent terrorists entering from overseas and using free movement laws to travel across the continent.
Sylvie Bermann, the French ambassador to Britain, told the Marr programme: 'What is obvious is that we have to strengthen our external borders.
'There's a lot to be done, including by the European Union, Frontex, and that's also the reason why we want to have those hotspots properly working and doing the screening of people.'
World leaders have united in offering support to France after Friday night's attack, which President Francois Hollande described as an act of war.
In a statement posted online ISIS drew a link between the deadly attack on Parisian diners and concert goers and France's involvement in airstrikes in Syria.
Britain is carrying out daily missile strikes against jihadis in Iraq but the Commons has not authorised RAF missions in neighbouring Syria.
But ministers insist they will only go ahead with a Commons vote if there is a 'consensus' that means MPs would back military action.Mr Cameron has repeatedly made clear he believes it makes no sense not to extend the strikes across a border which ISIS itself does not recognise.
Labour leader Jeremy Corbyn has vowed to oppose any extension of British involvement, calling for a 'peaceful' solution to the conflict.
However the hardline stance risks putting him increasingly at odds with voters appalled at the Paris attacks.
Labour's shadow justice secretary Lord Falconer called for 'a plan that covers the whole of the Middle East and addresses Syria'.
He said there needed to be 'a major international effort that needs to be thought-out in a way that convinces the people of Britain'.
Shadow foreign secretary Hilary Benn told Sky News that it was not possible 'to defeat Isil in Syria just by dropping bombs'.
Meanwhile a close ally of Mr Corbyn has said Labour will only consent to extending military action into Syria if there is a UN mandate to do so.
Speaking in the wake of the Paris terror attacks, the shadow international development secretary Diane Abbott, outlined the circumstances which will be required for her party to back a bid to extend the UK's military role from Iraq and into Syria.
She told Murnaghan on Sky News: 'As far as Labour's policy in relation to Syria, we actually discussed this at party conference and we have a policy.
'We can only agree to bomb in Syria first of all if there is a UN resolution and also, and this is my particular concern, if there is a plan to deal with the refugees that will result from further military action.'
When asked if the Paris attacks had changed any of that, Ms Abbott said: 'Yes, it is a game changer in that it makes the need to resolve the civil war in Syria even more urgent than it was and that's part of Labour party's policy, that we put the need for a diplomatic solution to the Syrian civil war right at the top of the agenda.'
Ms Abbott said defeating ISIS is 'not about dogma, it's not about gestures, it's about what works and in the end you have to resolve the civil war in Syria'.


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> Flowers >
Symphony in Pink
Your Montreal Florist
6334 rue Sherbrooke Ouest, Montreal
How desirable were orchids in nineteenth-century Europe? A legend says that 4,000 trees were once cut down just to collect orchid blooms. Luckily, we've since found better means of cultivating these exotic flowers. This arrangement with dendrobium orchids is suitable for any occasion. Colours may vary.
Product Code:
F Arr Orc 1
Montreal 04 July 2020 3:23 PM


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Year of Publication
- 2017 (2) (remove)
Document Type
- Report (1)
- Working Paper (1)
Potentials and limitations of different requirements (offsetting) in bilateral and global carbon pricing systems (2017)
In the Paris Agreement, the governments of the world have pledged to attain climate neutrality in the second half of this century. More precisely, in Art. 4.1 parties agreed to "achieve a balance between anthropogenic emissions by sources and removals by sinks of greenhouse gases". However, the collective as well as the majority of measures by individual countries fall short of embarking on a pathway towards that objective. But nevertheless, an increasing number of actors - countries, sub-national entities, as well as corporations - have stepped up their efforts and set themselves carbon neutrality goals. In this Policy Brief Lukas Hermwille and Markus Gornik portray the commitments of Costa Rica, Norway, Sweden, the City of Melbourne, Australia and the corporation Microsoft. All cases have set themselves ambitious neutrality goals and have implemented measures to achieve them. However, none of the cases will be able to achieve accomplish neutrality on their own, at least not on short-term. The remaining emissions will be compensated using carbon credits either from domestic offset schemes (Costa Rica) or from international schemes. For the time being, voluntary carbon neutrality goals, as presented in this Policy Brief, are an effective way to demonstrate leadership in climate protection. For the near future, pioneering actors that set voluntary carbon or climate neutrality goals could provide a significant source of demand for international carbon credits.