A new ionone derivative and six known flavonoids were isolated from the aerial parts of Isodon leucophyllus (Dunn) Kudo. Their structures were respectively elucidated as 13-carboxy-blumenol C (1), 5, 7, 3^, 4^-tetramethoxyflavone (2), cirsiliol (3), 5-hydroxy-6, 7, 3^, 4^-tetramethoxyflavone (4), 3^-hydroxy-5, 7, 8, 4^-tetramethoxyflavone (5), isosinensetin (6) and isoquercetrin (7), based on their spectra analysis. All of the six flavonoids were reported firstly from this plant.


Simple Summary Malignant Head and neck squamous cell carcinomas occur frequently, and several treatment regimens are used to fight disease progression. While anti-Epidermal growth factor receptor (EGFR) antibody cetuximab is applied successfully in many cases, therapy resistance occurs after a short period in numerous patients. We checked the hypothesis whether EGFRvIII or EGFR R521K variants can be responsible for antibody efficacy or therapy resistance. EGFRvIII, unlike stated before, was found extremely rarely (<1%), while EGFR R521K was present in over 40% of the patients and suggested to be important in the preclinical models, but not in the clinical cohort. Conclusively, our results suggest that neither EGFRvIII nor EGFR R521K variants are directly resulting cetuximab resistance in Head and neck squamous cell carcinoma patients. Abstract Background: Head and neck squamous cell carcinomas (HNSCCs) are among the most abundant malignancies worldwide. Patients with recurrent/metastatic disease undergo combination chemotherapy containing cetuximab, the monoclonal antibody used against the epidermal growth factor receptor (EGFR). Cetuximab augments the effect of chemotherapy; however, a significant number of patients show therapy resistance. The mechanism of resistance is yet to be unveiled, although extracellular alterations of the receptor have been reported, and their role in cetuximab failure has been proposed. Aims: Here, we investigate possible effects of the multi-exon deletion variant (EGFRvIII), and the single nucleotide polymorphism EGFR R521K on cetuximab efficacy. Results: Our results show that in HNSCC patients, the EGFRvIII allele frequency is under 1%; therefore, it cannot lead to common resistance. EGFR R521K, present in 42% of the patients, is investigated in vitro in four HNSCC cell lines (two wild-type and two heterozygous for EGFR R521K). While no direct effect is found to be related to the EGFR status, cells harboring R521K show a reduced sensitivity in ADCC experiments and in vivo xenograft experiments. However, this preclinical difference is not reflected in the progression-free or overall survival of HNSCC patients. Furthermore, NK cell and macrophage presence in tumors is not related to EGFR R521K. Discussion: Our results suggest that EGFR R521K, unlike reported previously, is unable to cause cetuximab resistance in HNSCC patients; therefore, its screening before therapy selection is not justifiable.


Abstract: During visually guided reaching and grasping, vision and proprioception of the hand are integrated to allow for maximal speed and accuracy of movement. Neurophysiological data indicate that BA5 in the posterior parietal cortex is one region in which information from the visual and proprioceptive modalities converge. In addition to movement accuracy, experimental data have demonstrated that preparation for a grasp will influence visual perception of objects in the context of the grasp. This indicates that proprioception can influence vision. This is consistent with a neuro-robotic model of visualproprioception interaction that we have recently developed in the context of visually guided motor control. The Multimodal Convergence Map (MMCM) is a self-organizing map connected bidirectionally to regions encoding visual and proprioceptive information, and thus implements this anatomically supported integration function of BA5. We performed experiments using a robot arm and the Spikenet vision processing system that was used to recognize the hand of the robot arm in different configurations. The task for the system is to recognize its hand as the hand moves through a continuous trajectory of postures. Based on data from the literature, we hypothesized that from the unbounded possibilities that the visual image of the hand could take, proprioception of the hand would significantly reduce those possibilities, and allow the visual system to predict or anticipate the approximate image of the hand. This prediction would allow the system to perform more optimally by restricting and refining the possible models used in the recognition. Our experiments revealed that when the MMCM model was used, the visual response selections were significantly refined (the receptive properties of the Abstract Print View http://www.abstractsonline.com/Plan/AbstractPrintView.aspx?mID=2...


There is a potential threat to long-period operation in the sector of embankment upon the slope.Process of infiltration can not only disturbe field of temperature,but creates infiltrating force.The force can reduce the stability of embankment on the slope in the southern limit region of the permafrost zone.Stability of embankment of the Qinghai-Tibet railway on slope is analyzed in the event of rainstorm where the result of infiltrated calculation is used.Consequently,the stability continuously decreases.The minimal value appears after about two days of rainfall.


Objective:To compare the difference of CD4+CD25+ regulatory T cells and Foxp3 expression in the periphery blood and tumor microenvironment of non-small cell lung cancer(NSCLC) patients with different lymph node metastasis status.Methods:46 NSCLC patients were divided into two groups according to their lymph node metastasis status.The proportion of CD4+CD25+ T cells was analyzed by flow cytometry,the mRNA expression of Foxp3 was detected by real-time PCR and immunohistochemistry was applied for detecting Foxp3 expression in tumor microenvironment.The levels of TGF-β and IFN-γ in periphery blood and tumor homogenates of patients were tested by ELISA.Results:Foxp3 expression in the metastatic lymph nodes was stronger than that in the non-metastatic ones of NSCLC patients.Foxp3 expression in the tumor microenvironment as well as the levels of TGF-β in tumor homogenates of NSCLC patients with metastatic lymph nodes were all higher than those in patients with non-metastatic ones.There was no significant difference in the proportion of CD4+CD25+ T cells,Foxp3 expression and levels of TGF-β and IFN-γ in the periphery blood of two group patients.Conclusion:Foxp3 expression in the tumor microenvironment and TGF-β level in tumor homogenates of NSCLC patients with metastatic lymph nodes were higher than those of patients with non-metastatic ones,which suggested more serious local immunosuppression situation in this kind of NSCLC patients.


Objective This study aims to determine the maximal inclusion level of defatted (d-) Tenebrio molitor larvae meal (TM) able to replace dietary fishmeal (FM) without compromising growth performance, general metabolism, and flesh quality traits in European sea bass, and to evaluate the major underlying physiological mechanisms. Materials and Methods Fish (55 ± 2 g) were fed with diets containing increasing levels of dTM: 0, 40, 80 and 100% (CTRL, TM40, TM80, and TM100, respectively) to replace FM. After 10 weeks of feeding, the growth performance, nutrient and energy balance, intestinal integrity, plasma metabolites and the expression of genes related to growth and nutrient metabolism, in liver and muscle were determined. The fatty acids (FA) profile, textural properties and color were also evaluated in muscle. Results Protein and lipids digestibility remained unaltered up to 80% dTM inclusion. Growth performance parameters were similar among dietary treatments. The dTM inclusion increased the hepatosomatic index in fish fed TM100. Muscle eicosapentaenoic acid, docosahexaenoic acid and n-3 long-chain polyunsaturated FA levels were maintained up to 80% dTM inclusion, but total cholesterol and non-esterified FA increased with dietary dTM inclusion. In liver, the expression of elongation of very long-chain FA protein 6 (elovl6) and FA desaturase 2 (fads2) did not change in fish fed TM40 and TM80, but elovl6 decreased whilst fads2 increased in fish fed TM100 when compared to those fed CTRL. The expression of cholesterol 7 alpha-monooxygenase (cyp7a1) decreased with dietary dTM inclusion. In muscle, the expression of myoblast determination protein-2 (myod2) decreased in fish fed TM80 and TM100. Conclusion It is feasible to substitute dietary FM by dTM up to 80% in European sea bass without detrimental effects on nutrient digestibility, growth performance and associated genetic pathways, whilst assuring fillet nutritional value for human consumption.


This study reveals the arrival of prints and books to the North of Spain acquired by the Italian merchant Antonio Pisano in Rome during a trip of 1582-1583. The voyage was financed thanks to the temporary commercial company established between Pisano and the Genoese Juan Luis de Musante, royal master-builder to Felipe II in Navarre, and both residents in Pamplona. The works include engravings of sacred and profane themes by the most important engravers of the epoch, such as the Dutch Cornelis Cort and the Mantuans Adamo and Diana Ghisi, in addition to books of figures, some by outstanding artists such as Michelangelo or Polidoro da Caravaggio.


![Figure][1]

Low (left) and high (right) glucose levels alter the morphology of the vacuole (red) by regulating the phosphorylation of Atg18 (green).

Tamura et al. describe how phosphorylation modulates the phospholipid-binding capacity of a protein that regulates autophagy and vacuole


Introduction: Knowledge mobilization: The new research imperative Prof Tara Fenwick and Prof Lesley Farrell Part 1: Considering the Issues and Players 1. Theory, Research and Practice in Mobilizing Research Knowledge in Education Ben Levin and Amanda Cooper 2. Exploring Strategies for Impact: Riding the Wave with the TLRP Andrew Pollard 3. 'User Engagement' and the Processes of Educational Research Anne Edwards Part 2: Politics in Knowledge Flows: Research Meets Policy 4. Affairs of the Smart: How Researchers and Decision-makers Became Bedfellows in Education Charles Ungerleider 5. Knowledge Stocks and Flows: Research Meets Policy Jenny Ozga 6. Art, Community and Knowledge Flows Margaret Somerville 7. Fighting for the Role of the Nation State in Knowledge Mobilisation and Educational Research: An Autoethnography of a Mobile Vietnamese Scholar Phan le Ha Part 3: Languages and Enactments of Knowledge Mobilization 8. Finding Common Perspectives: Knowledge Mobilization in a Transnational Museum Project Ian Dyck 9. Bridging Journalistic-Academic Divides to Promote Democratic Dialogue and Debate Deirdre Kelly and Michelle Stack 10. Ethics and Experimennts with Art in Mobilizing Educational Research Tara Fenwick 11. Balancing Knowledge Management and Knowledge Mobility in the University Chris Chesher and Sarah Howard Part 4: Responsibilities and Rights in Mobilizing Knowledge 12. Regulating Knowledge in the Global Knowledge Economy Michael Fraser 13. Scholarly Publishing, Knowledge Mobility and Internationalisation of Chinese Universities Rui Yang 14. Explicating a Shared Truth about a Colonial Past: Knowledge Mobilization, Coalition Building, Aboriginal Literature and Pedagogy Dolores van der Wey 15. Deparochializing Educational Research Three Critical Illustrative Narratives Bob Lingard, Ian Hardy and Stephen Heimans


Metallicity gradients are important diagnostics of galaxy evolution, because they record the history of events such as mergers, gas inflow, and star formation. However, the accuracy with which gradients can be measured is limited by spatial resolution and noise, and hence, measurements need to be corrected for such effects. We use high-resolution (∼20 pc) simulation of a face-on Milky Way mass galaxy, coupled with photoionization models, to produce a suite of synthetic high-resolution integral field spectroscopy (IFS) datacubes. We then degrade the datacubes, with a range of realistic models for spatial resolution (2−16 beams per galaxy scale length) and noise, to investigate and quantify how well the input metallicity gradient can be recovered as a function of resolution and signal-to-noise ratio (SNR) with the intention to compare with modern IFS surveys like MaNGA and SAMI. Given appropriate propagation of uncertainties and pruning of low SNR pixels, we show that a resolution of 3–4 telescope beams per galaxy scale length is sufficient to recover the gradient to ∼10–20 per cent uncertainty. The uncertainty escalates to ∼60 per cent for lower resolution. Inclusion of the low SNR pixels causes the uncertainty in the inferred gradient to deteriorate. Our results can potentially inform future IFS surveys regarding the resolution and SNR required to achieve a desired accuracy in metallicity gradient measurements.


We present a surgic solution that we adopted in a case of diffuse neoplasia from the upper urinary tract to the bladder and the prostatic urethra. Case 67 year-old male, has been submitted to bladder mapping with results of diffuse CIS and sequential immunotherapy with BCG. The three month control had pathological findings of CIS in the bladder and in the prostatic urethra. The staging has shown neoplasia in both kidneys. We had performed a cystoprostatectomy with a bilateral ureterectomy and cleaning of the intrarenal tissue. We had performed a bilateral pyelocutaneous ileal conduit in accord with Holland. Results The kidney parameters at 6 months were normal and the patient was well. The control, in general anesthesia with a pediatric gastroscope, in the pelvis and calyx with x-ray facility, didn't show a recidive in the kidney. Otherwise in annual control a little neoplasia in the right kidney was found. In the successive control at 18 and at 24 months we had found no signs of neoplasia. Conclusions Despite this extreme case, in which the neoplasia is in all of the urinary tract, it is possible to preserve the kidneys, to have a good oncological result and to preserve the renal function with a good quality of life, to avoid or to delay the bilateral nefrectomy.


Biotechnologies could supply inexpensive, environment friendly and effective materials for new nonstandard and concurrent solutions. The present work's focus was on acquiring new physical data for application in electronics and medicine of biogenic materials obtained due to the metabolism in laboratory conditions of iron-oxidizing bacteria from the genus Leptothrix. Powders and coatings on glass samples were under investigation. XRD and Raman Spectroscopy analysis of the data collected show that the Fe2+-depending from the growth media could transformed into Fe3+ or Fe2.5+ in the form of two types of oxides/hydroxides such as magnetite (Fe3O4) and lepidocrocite (ɣ-FeOOH), all with nanostructured morphology. Biotechnology for obtaining one biogenic iron phosphate hydroxide (ferrian giniite) - (Fe5(PO4)4(OH)3.2H2O) was also developed. The ferrian magnetic material is dispersed in the walls of biogenic tubular structures. The average particle's size and crystalline structures of bio-products were investigated. Results based on PPMS measurements on the magnetic properties were reported. The new biogenic materials showed superparamagnetic behaviour and high sensitivity to electromagnetic radiation and have real potential for application in electronic and information technologies.


Background: All women go through menopause stage after a certain age and menopause women suffer from different medical problems which needs specific attention. Aim: The aim of the study is to find out the consequences of postmenopausal women attending in the hospital for medical treatment. This study also identifies the outcome of different consequences in those patients. Methods: Among 105 patients were selected for the study purposively those who were admitted in the gynecological ward in Kumodini Women's medical college from March 2008 to February 2009. All patients were undertake clinical examination and find out the consequence of menopause in one year observation period. A structured questionnaire was used to interview the patient and information also collected from patient's treatment file. Statistical analysis was performed by using statistical software SPSS 11.5 window. Results: Among 105 patients, age was above 40 years. Most of the patients were coming from low and low middle income society having maltiparous We have examined that most of the menopausal women developed uterovaginal prolapse was 63.8%, genital malignancies was found among 17.4% patients and rest were faced other benign disorders (19%) which includes leiomyoma, pelvic inflammatory diseases (PID), uncontrolled bleeding, urinary tract infections (UTI) and ovarian cysts. Conclusions: In Post menopausal phase of women in Bangladesh suffered from different health consequences like uterine prolapse, benign diseases and carcinoma which causes of hospital admission for better management. KYAMC Journal Vol. 3, No.-2, January 2013, Page 290-293 DOI: http://dx.doi.org/10.3329/kyamcj.v3i2.15169


Carving association rules from any available set is a predefined problem and there are a variety of methods available for the extraction of association rules. Almost in all the cases the major emphasis is given to the generating most occurring itemsets rather than the extraction of association rules. Only a few numbers of researchers have through some light on this problem. Extracting generally most occurring itemsets for sometimes does not guarantee that particular dataset will occur in its lifetime. . For finding local association rules of the form A  X A, where X and A are itemsets that hold in the interval [t, t] and X A . In order to calculate the confidence of the rule A  X – A in the interval [t, t], it is required to know the supports of both X and A in the same interval [t, t]. The supports of X and any of its subset A may not be available for the same time interval A may be frequent in an interval greater than [t, t]. So, they have loosely defined local association rule as confidence in the rule A  X – A can't be calculated in interval [t, t]. In this paper, we present a latest approach for finding association rules from generally most occurring item sets using Rough Set and Boolean reasoning. The rules carved are called local association rules. The efficacy of the proposed approach is established through experiment over retail dataset that contains retail market basket data from an anonymous Belgian retail store.


Electron transport through a quantum wire in the presence of external periodic energy-level modulations with different on-site phases is studied within the time evolution operator method for a tight-binding Hamiltonian. It is found that in the presence of spatial symmetry of the system and no source–drain and static gate voltages the pumping current can be generated. Moreover, for a wire which is tunnel-coupled to the underlying substrate, the current flowing through an unbiased wire does not fade away but increases with the wire–surface coupling. For randomly chosen phases at every wire site two regimes of the phase-averaged current are found which are related to small and high wire density of states.


Non-trivial outer algebra automorphisms may be utilized in λ-deformations of (gauged) WZW models thus providing an efficient way to construct new integrable models. We provide two such integrable deformations of the exact coset CFT SU(2)k×U(1)/U(1)q with a vector and axial residual gauge. Besides the integer level k and the deformation parameter λ, these models are characterized by the embedding parameter q of the U(1) factor. We show that an axial-vector T-duality persists along the deformations and, therefore, the models are canonically equivalent. We demonstrate integrability even though the space is non-symmetric and compute the RG-flow equations for the parameters λ and q. Our example provides an integrable deformation of the gravitational solution representing a Euclidean three-dimensional black string. ar X iv :2 01 2. 08 52 7v 1 [ he pth ] 1 5 D ec 2 02 0


To ease the problem of unemployment among high school and university graduates in Iran the government has pursued a policy to extend credit to them provided that they join production co-operatives. The credit co-operatives are supervised by a government body named ?The Center for Development of Productive and Development Services* (hereafter, called Center). The loans are interest free and the repayment period of the loan is fifteen years. The repayment would be started after project being completed. According to available statistics, in 1984, the total number of co-operatives amounted to 4,440 in agriculture, manufacturing and services with 36,922 members1.


THE INVENTION CONCERNS A INOCULUM BACTERIAL, USEFUL IN PARTICULAR FOR THE DETERIORATION OF ORGANIC MATTER IN SOIL, CONSISTS OF A MIXTURE OF DIFFERENT KINDS OF MICROORGANISMS THAT MAY LIVE IN SOIL AND NON PATHOGENIC HUMANS, ANIMALS AND PLANTS CHARACTERIZED BY IT'S AEROBIC MICROORGANISMS STRICT OR OPTIONAL AEROBIC AND MESOPHILE, UNDER EXISTING FORMS rESISTANT STORAGE, dEGRADING CELLULOSE, the HEMI-CELLULOSE LIGNIN AND PROTEIN COMPONENT MATERIALS OF ORIGIN ORGANIC VEGETABLE OR ANIMAL.


As number of the buildings increases, it shows new trends such as twisted, tilted, taperer shape. As a structural solution for the new trend buildings, diagonal grid (Diagrid) structural system was developed. Since the diagrid system is a new one, there is no reliable response modification factor in the codes available. Therefore, that of the braced frame is used for diagrid system. The purpose of this study is to evaluate the value of response modification factor for diagrid structural system. The parameters are the building heights from 4 stories to 36 stories and nonlinear static analyses was used to find the behaviour of the diagrid system. As a result, the response modification factor of the diagrid was proposed based on the pushover analysis.


In a world where opportunities and chances are common, the phenomenon referred to as "generation maybe" describes people in their 20s and early 30s who are usually being indecisive. With the increase in breadth of information and choices, the number of people who are hesitant in deciding whether to purchase increases at a fast pace, as does the number of products and services targeting this group. In order to enhance our understanding of the phenomenon of consumer hesitation, this study explores contextual factors and consumer characteristics that affect consumer hesitation in the purchase decision-making process. Specifically, this study examines whether seven contextual factors, self-determination tendencies, and five decision-making styles influence consumer hesitation in the product decision making process. An online survey was administered to test our research questions. A total of 309 Korean consumers (female


This research was conducted in Office of Public Works Lubuklinggau City. The purpose of research to determine the influence of employee placement, work discipline and commitment to employee performance in Office of Public Works Lubuklinggau City both simultaneously and partially. The sample in this research as many as 60 employees in Office of Public Works Lubuklinggau City. Data analysis technique used in this research is multiple linear regression test, coefficient of determination test, F test and t test. The results obtained are 1). The partial test (t test) performed proves employee placement has a significant effect on employee performance where tcount 4,419 > ttable 1,991 and also sig 0,009 ttable 1,991 and also sig is 0,004 ttable 1,991 and also sig is 0,026. 4). Employee Placement, Work Discipline and Commitment have significant influence simultaneously on Service in Office of Public Work Lubuklinggau City, where Fcount  4,518> Ftable 2,73 and also sig of 0,020 < 0.05.


The sole surviving monumental column from the Basilica of Maxentius and Constantine is the focus of Paul V, the Column of the Virgin, and the New Pax Romana. In 1613 Pope Paul V removed and re-erected this column at the center of Piazza S. Maria Maggiore in Rome, crowning it with a gilded bronze statue of the Virgin and Child. After reconstructing the little-known history of the monument and situating it within the history of honorific columns and Paul's urban planning, Steven F. Ostrow examines the antiquarian interest it long held, what was known about its original context, and the symbolic associations with which it was endowed. This close reading of Paul's monument demonstrates how, by appropriating the column and topping it with a statue of the Virgin, the pope eloquently expressed the Church's longstanding belief in Mary as a bringer of peace and the protector of Rome.


Several factors,such as the void location and the void shape,affect the bearing capacity behavior of shallow foundation.The cavity effect on the bearing capacity of strip foundation above a void is investigated analytically by using the elastoplastic 2D FEM.The relation between load and settlement of shallow foundation is analyzed for different conditions of the void;and the failure mechanism of ground is also examined.The analytical results indicate that there is a critical effect region for the void under the shallow foundation.Only when the void is located within this region,the bearing capacity and settlement of strip foundation vary considerably with the void location.In addition,based on the above finite element results,a simple calculation method is proposed for the cavity effect on the bearing capacity of strip foundation.


Background: The authors examined the notion that a reduction in succinylcholine dose from 1 mg/kg to ≈0.6 mg/kg would allow a faster recovery of spontaneous ventilation and reduction in the incidence of hemoglobin desaturation during the period of apnea in simulated complete upper airway obstruction situations. Methods: This prospective, randomized, double-blind study involved 60 patients. After preoxygenation to an end-tidal oxygen concentration >90%, patients were anesthetized with 2 &mgr;g/kg fentanyl and 2 mg/kg propofol. After loss of consciousness, patients were randomly allocated to receive 0.56 or 1.0 mg/kg succinylcholine or saline (control group). Oxygen saturation was monitored continuously at the index finger. When the patient became apneic, the face mask was removed and the patient's airway was left unsupported. If the oxygen saturation decreased to 90%, the face mask was reapplied, and ventilation was assisted until the patient was awake. Time from injection of the study drug to the first visible spontaneous diaphragmatic movements was noted. Results: Oxygen saturation decreased <90% in 45%, 65%, and 85% of patients in the control, 0.56 mg/kg, and 1.0 mg/kg succinylcholine groups, respectively (P = 0.03). Corresponding times (mean ± SD) to spontaneous of diaphragmatic movements were 2.7 ± 1.2, 4.8 ± 2.5, and 4.7 ± 1.3 min, respectively. These times were longer (P < 0.001) after either dose of succinylcholine compared with controls. Conclusions: Reduction in succinylcholine dose from 1.0 mg/kg to 0.56 mg/kg decreased the incidence of hemoglobin saturation <90% from 85% to 65% but did not shorten the time to spontaneous diaphragmatic movements. A significant fraction of patients would be at risk if there were failure to intubate and ventilate whether succinylcholine is administered or not and regardless of the dose of succinylcholine administered.


A revolution in medical science was marked with the advent of imatinib, a site‐specific drug for the management of patients with chronic myeloid leukemia (CML). Imatinib mesylate (also known as Glivec, Gleevec, STI‐571, CGP57148), an orally administered 2‐phenylaminopyrimidine derivative approved by FDA in 2001 for the treatment for CML, is highly effective in treating the early stages of CML, but remission induced in advanced phase was observed to be relatively short‐lived. The primary cause of resistance in patients with CML is the mutations in the BCR–ABL kinase domain. This review discusses the different mechanisms leading to imatinib resistance and various treatment options to over‐ride imatinib resistance.


The primary challenges in implementing a Si based quantum cascade laser are discussed. Intersubband absorption measurements were carried out on a series of modulation doped multiquantum well structures. The spectra were compared to the predictions of a 6 band k.p model, which confirmed the excellent accuracy of the model, and its ability to predict the bandstructures of more complicated cascade structures. A detailed structural analysis demonstrated excellent growth quality, with an interface roughness of < 0.4 nm. Electroluminescence measurements on cascade structures with doped contacts, processed as finger structures and waveguides of various sizes, enabled a quantitative analysis of the active region performance. The upper state lifetime τnr was ~ 100 fs, leading to a total active region optical gain of ~ 2 cm -1 , a factor of ~ 10 lower than the estimated total losses due to free carrier absorption. The total emitted power and the linewidth of the intersubband emission saturate above ~ 6.5 kA/cm 2 , probably due to misalignment of the injector levels at high biases. The effect of leak currents and interspersed light hole states on the intersubband emission are considered.


Introduction: War injured patients from Syria are constantly being transferred to Lebanon for management after rudimentary primary closure of their wounds is done at the combat zone.
Case presentation: The cases presented below represent some of the extreme cases of delayed presentation of peri-ocular trauma and the adaptations reconstructive surgeons had to make for conventional techniques.
Conclusion: We describe in our paper modified techniques in reconstructing delayed presentations of peri-ocular injuries secondary to war trauma in Lebanon and Syria.


The provision of genetics evaluation and counseling services is one impor tant aspect of comprehensive care for individuals with Prader-Willi syn drome (PWS) and their families. This distinctive counseling service should be offered to parents of children who are known or suspected to have PWS. It is best provided by a medical geneticist in conjunction with a genetics nurse specialist or a genetics counselor. Unfortunately, the importance of genetics evaluation and counseling is frequently underestimated and, too often, the process itself is misunder stood. For example, some team professionals believe they can provide genetics counseling as well as a trained geneticist/counselor. Also, there are instances in which parents of affected children are not referred for genetics consultation because they do not plan to have more children; thus, the reproductive counseling aspect of services is not considered necessary. Understanding the genetic aspects of PWS and provision of reproductive information are just two parts of the total genetics evaluation and counsel ing process. It reaches beyond confirmation of diagnosis and informative counseling and includes both support and follow-up counseling as well. Whereas it may appear that there is considerable overlap in the informa tion provided by the genetics professionals and other members of the health care team, it is most likely that benefits accrue from purposefully repeated discussions of pertinent facts. Information about PWS restated in a variety of ways can enhance understanding. Certainly, qualified genetics professionals do provide a reliable resource and sensitive ongoing support for families over an extended period of time.


Interview with H. E. Maris, a seaman in the US Navy during WWII. He answers questions about his service to the military and his experiences of coming home


Corruption has been shown to discourage entrepreneurship in transition economies and previous research corroborates that individual dispositions affect entrepreneurial intentions. It is less clear, however, to what extent individual attributes impact entrepreneurial behaviours in different institutional contexts. Here, we assess the cross-level moderation effect of corruption at the national level and attributes of entrepreneurs at the individual level, on the likelihood of individuals entering into entrepreneurship. Hence, we contribute to the emerging literature examining contextual influences on entrepreneurialism by focusing on transition economies. Our results indicate that self-efficacy, fear of failure and opportunity recognition may be more important determinants of entrepreneurial intentions in less corrupt contexts, whereas ties with other entrepreneurs become more relevant in contexts where corruption is endemic.


The paper introduces the necessity of modified recycle of waste polyethylene,and reviews filling modification situations of waste polythylene home and abroad from the following three aspects:filling modified recycle of inorganic particles,reinforcing modification of fiber and toughening modification of elastomer.


:  The landlocked dwarf ayu (koayu) Plecoglossus altivelis altivelis in Lake Biwa is one of the most important predators of planktonic crustacea. As part of predation ecology of koayu, the process of gastric evacuation was examined by two kinds of aquarium experiments. In the first experiment, koayu was fed for 1 h and the stomach contents after feeding was enumerated. Stepwise multiple regression analysis of the number of prey in the stomach on eight independent variables (numbers of six kinds of behavior during feeding, food concentration, and predator mass) selected only the number of foraging attacks as the predictor variable. In the second experiment, koayu was starved for 2 h after 1 h feeding. Prey number in the stomach before starvation was calculated from the number of foraging attacks and was compared with the number actually enumerated after starvation. Almost all stomach contents were digested and evacuated during the 2-h starvation. The stomach contents of koayu were, hence, ingested less than 2 h before the moment of collection. The present results enabled the estimation of predation rate in the field from the mass of stomach contents.


The purpose of this study was to determine the extent of the relationship between four measures of educational experience, a measure of job performance, and six dimensions of job satisfaction for a population engaged in outside sales.


Ab*str»ct. Tunnel junctions with high-Tc superconductor thin film(dc-sputtered from УВа2Си30 7_" target) as tunnel barrier were obtained. Tunnel characteristics with zero-bias anomaly in d l / iV suggest amorphous nature of thin YBaCuO Шт. The Raman and d1V /d l1 spectra prove that the layers obtained have semiconducting YBa2CuOs structure and are probably doped with BaCuOj. The Scanning Tunneling Microscope (STM) surface topography of YBaCuO layers shows the amorphous nature before annealing and some structure features the emerging of grain boundaries after annealing.


Parabolae (Par) VII is set in two separate scenarios each of which contains its own topographical complexity, and each of which proposes an answer to the double question, "Where do you come from, and where do you go?" The overall scenario and spiritual framework of the narrative is the monastic plot. This plot is unfolded around the via of the monk (with a short necessary deviation into the cubiculum) and tells how the monk went to the market and met Christ on his way. The via of the monk takes its point of departure in the monastery from which he sets out and is aimed at the heavenly kingdom that he buys on his way. Anthropologically, the two different yet interactive plots of Par VII each has its specific stress on the aspect of respectively viator and peregrinus.Keywords: Anthropology; Christ; monastic plot; monk; Parabolae (Par) VII; peregrinus; spiritual framework; viator


Attending to the relationship between where individuals start (e.g., their initial status) and how rapidly they progress (e.g., their rates of change) can help draw attention to possible concerns regarding the distribution of student achievement within schools in longitudinal studies of school effectiveness. Focusing on the relationship between initial status and rates of change, we address questions concerning equity: Why is it that student achievement is distributed in a more equitable fashion in some schools than in other schools? To what extent might this be due to school characteristics, school policies, or school practices? Do schools that start off with high mean achievement have a more positive relationship or negative relationship? To address questions of this kind, we present a latent variable regression modeling strategy that incorporates latent variable regression into a three-level hierarchical modeling framework (LVR-HM3). To illustrate key ideas and the distinctive features of the LVR-HM3, we fit a series of LVR-HM3s to the data from the Longitudinal Study of American Youth (LSAY) using the Gibbs sampler. We also present results from sensitivity analyses that involve employing t - distributional assumptions in LVR-HM3s, and we examine the convergence of the Gibbs sampler using different formulations and parameterization of the LVR-HM3. In a final section, we discuss some implications and possibilities that arise in longitudinal multi-site intervention studies using LVR-HM3s.


Despite significant progress in research, practice, and policy over the past few decades, many children and youth continue to experience poor mental health outcomes based on their socioeconomic disadvantage, ethnic or racial minority status, or immigrant status. As a result, many of these children fail to adequately meet developmental tasks, demands, and transitions, such as entry into and successful achievement in school, interpersonal and peer relationships, and civic functioning. Compounding these challenges for minority children and youth is their low levels of mental health service utilization, impediments to accessing care, and care that is not culturally competent or does not conform to evidence-based guidelines.


It seems like such a simple device: a U-shaped piece of metal with a stem to hold it; a simple mechanical object that, when struck lightly, produces a single-frequency pure tone. And yet, this simple appearance is deceptive because a tuning fork exhibits several complicated vibroacoustic phenomena. A tuning fork vibrates with several symmetrical and asymmetrical flexural bending modes; it exhibits the nonlinear phenomenon of integer harmonics for large-amplitude displacements; and the stem oscillates at the octave of the fundamental frequency of the tines even though the tines have no octave component. A tuning fork radiates sound as a linear quadrupole source, with a distinct transition from a complicated near-field to a simpler far-field radiation pattern. This transition from near field to far field can be seen in the directivity patterns, time-averaged vector intensity, and the phase relationship between pressure and particle velocity. This article explores some of the amazing acoustics that this simple device can perform.


Bureau of Alcohol, Tobacco and Firearms regulations require that a straight whiskey be aged in a freshly charred oak barrel for a minimum of 2 years and that it not be colored with added caramel. The regulations, however, permit addition of caramel in blended whiskeys. Blended whiskeys are usually produced by mixing a straight whiskey with neutral spirits which causes loss of color intensity. Caramel addition is permitted to compensate for this loss. Thus, it is not possible to authenticate the standard of identity of a straight whiskey by measurement of color intensity, Our investigations suggest that furfural (2-furaldehyde) and 5-hydroxymethyl-2-furaldehyde are imparted into a straight whiskey during aging in a freshly charred oak barrel. Caramel, on the other hand, imparts only 5-hydroxymethyl-2-furaldehyde. Thus, the measurement of the concentrations of furfural and 5-hydroxymethyl-2-furaldehyde and their ratio could effectively authenticate the standard of identity of straight whiskeys. This study shows that straight whiskeys aged in freshly charred oak barrels for a period of 2 years or more have a 2:1 or higher ratio of furfural to 5-hydroxymethyl-2-furaldehyde. A high-performance liquid chromatographic method for the determination of furfural and 5-hyroxy- methyl-2-furaldehyde at low parts-per-million levels is described.


The recently amended Constitution and Rules of the New York Stock Exchange1 permit public ownership of member corporations by allowing them to issue "freely transferable securities." Previously, securities of these firms could be owned only by a limited class of persons each of whom had to be approved in advance by the Exchange.2 In the case of a proposed issuance or transfer of voting securities, such approval would not be granted to individuals other than full time employees of the member corporation.3 Once having become a shareholder, an individual who subsequently wished to dispose of his voting shares was required to sell only to a person approved by the Exchange as an "allied member"4 and had to give the member firm a right of first refusal on any proposed sale. The new rules provide a mechanism by which the member corporation, at its election, can constitute all or a part of its stock as freely transferable, i.e., issuable and transferable without prior approval of the Exchange. The objective of the Exchange in making these changes was to provide its member corporations with the ability to raise permanent capital through the public sale of securities. Equally important, however, from the point of view of the Exchange, was the preservation in the new rules of its self -regulatory function over member organizations. The old methodology, which utilized direct Exchange control over shareholders to insure compliance by member corporations with the regulatory pattern, was clearly inconsistent with the concept of public ownership; the new approach, therefore, narrows the primary


The convergence of artificial intelligence, high-performance computing (HPC), and data science brings unique opportunities for marked advance discoveries and that leverage synergies across scientific domains. Recently, deep learning (DL) models have been successfully applied to a wide spectrum of fields, from social network analysis to climate modeling. Such advances greatly benefit from already available HPC infrastructure, mainly GPU-enabled supercomputers. However, those powerful computing systems are exposed to failures, particularly silent data corruption (SDC) in which bit-flips occur without the program crashing. Consequently, exploring the impact of SDCs in DL models is vital for maintaining progress in many scientific domains. This paper uses a distinctive methodology to inject faults into training phases of DL models. We use checkpoint file alteration to study the effect of having bit-flips in different places of a model and at different moments of the training. Our strategy is general enough to allow the analysis of any combination of DL model and framework—so long as they produce a Hierarchical Data Format 5 checkpoint file. The experimental results confirm that popular DL models are often able to absorb dozens of bit-flips with a minimal impact on accuracy convergence.


patient as the subject of this note, though extremely rare, is by no means unprecedented. Thus Osier and M'Crae,2 in an analysis of 7000 cases, found six between the ages of 10 and 20 years. From the literature they collected thirteen cases between 10 and 20, and six actually below the age of 10. Hale White,3 writing in Allbutt's System, regards some of this last group as more than doubtful. It is interesting to note that one of these was described as congenital (Williamson and Widenhofer), while another was found at autopsy in an infant of five weeks (Collingworth). Hale White3 goes on to say that probably some of the reported cases were sarcomatous, while Hussey, reporting a case of gastric carcinoma in a woman of 20, mentions that " Fenwick, Osier, and others think it very probable that cases of lymphosarcoma and hypertrophic stenosis of the pylorus were mistaken for carcinoma." It seems to be agreed that the frequently quoted case of Norman Moore's of carcinoma of the stomach in a girl of 13's


Blood-CSF barrier alterations had been demonstrated in children with sepsis and claimed to be a useful indicator of infection. No information is available, whether infection affects the barrier in term and preterm neonates. We studied 58 neonotes (31 term; 27 preterm: GA 28-3, mean 32.1 wks). Sepsis with positive blood culture was present in 11/31 term infants and 7/27 prematures. Albumin (Alb) and IgG levels were measured by immunodiffusion in serum and CSF sampled to exclude meningitis. Results (mean ± SD) :CSF/serum ratios of Alb and IgG were higher (p<0.05 unpaired t-test) in all groups of preterm compared to term infants. Sepsis and amnionitis had no significant influence on the blood-CSF barrier. Our data of noninfected infants agree with previous reports. Forming from our data the Link's index (IgG ratio/Alb ratio), it appears that local CNS IgG production is negligible in these infants. In conclusion blood-CNS barrier permeability is inversely related to maturity. In contrast to previous speculations it is not a useful indicator of neonatal sepsis.


Protection of power transformer is a very challenging problem in power system relaying. Since it is very important to minimize the over loading and duration of unwanted outages, there is a high demand imposed on power transformer protective relays. Various relaying principles have been proposed and used to protect transformers against different types of faults. Relays involving over current, over voltage and overheating principles protect the transformers against overloads and externally applied conditions.The main objective is to protect the entire distribution system against tapping of power fro m unauthorized points by using SCADA, Zigbee. SCA DA is used for sup ervisory control and monitoring. Zigbee technique acts as a commun ication med iu m between the mast er and slave devices. To implement CAN protocols for message conveyance between master and slave devices and to develop the hardware using microcontroller based relay system.


Integrated navigation and pilotage systems are mainly used in missiles, bombs and unmanned armed vehicles designed for combat purposes of moving air, ground and surface ships. The purpose of these control systems is to obtain a direct hit or bringing those objects close enough to the surroundings, allowing it to be destroyed by the warhead.


Study Objective. To compare the effects of vecuronium administered as an intravenous continuous infusion versus intermittent bolus doses in patients treated with therapeutic hypothermia after sudden cardiac arrest (SCA).


Taking VC as reference,three kinds of methods(2,2-diphenyl-1-picrylhyd-razyl radical scavenging,ferric reducing power and total antioxidant) were performed to detect the antioxidant activity of flavonoids in vitro.These results indicated that the more concentration Acanthopanax trifoliatus flavonoids extracts were,the stronger antioxidant was.But to some extent,the antioxidant showed subtle change with the concentration increasing.In general,the optimal concentration for anti-oxidant was 45mg/mL.Total flavonoids from leaves of Acanthopanax trifoliatus have better antioxidant activity than VC.This research can provide theoretical basis for the good control of flavonoids usage amount.


Spin properties and spectral variations of high mass X-ray binary 4U 2206+54 are studied with long-term hard X-ray monitoring observations by INTEGRAL. A long-period X-ray pulsar of P_spin\sim 5558 s has been identified in 4U 2206+54. The spin evolution of the neutron star in 4U 2206+54 is detected with the INTEGRAL/IBIS data. From 2005 to 2011, the spin period of the neutron star in 4U 2206+54 varies from \sim 5558 s to 5588 s. The average spin-down rate in the last 20 years is derived as \sim 5\times 10^{-7} s s^{-1}. 4U 2206+54 is a variable source with luminosities of \sim 10^{35} - 10^{36} erg s^{-1} in the range of 3 -- 100 keV. Its spectrum can be described by an absorbed power-law model with exponential rolloff. The hydrogen column density and photon index show the anti-correlations with hard X-ray luminosity: low column density and small photon index at maximum of luminosity. This spectral variation pattern suggests that 4U 2206+54 would be a highly obscured binary system. Furthermore, the possible cyclotron line features are searched for in the spectra of different luminosities. The possible cyclotron absorption feature around 30 keV is not confirmed in our work. The physical origin and evolutional track of this very slow pulsation neutron star are still unclear. We suggest that 4U 2206+54 would be a young system with the long-term spin-down trend, would evolve to a longer spin period range and transit to the spin-up phase similar to 2S 0114+65. These very slow pulsation X-ray pulsars would belong to a new class of compact objects -- accreting magnetars.


Graphite electrodes were modified with specifically designed Os-complex modified electrodeposition polymers exhibiting a formal potentialofthepolymer-boundcomplexofabout0to20mV(vs.Ag/AgCl/3MKCl)whichisonlyabout100mVanodicoftheformalpotentialofpyrroloquinolinequinone(PQQ)inPQQ-dependentglucosedehydrogenase(PQQ-GDH).Theefficiencyofwiringthepolymer-entrappedPQQ-GDHwasdependentonthenatureofthepolymerbackbone,thecrosslinkingwithbifunctionalcrosslinkersandtheco-entrapmentofmulti-walledcarbonnanotubes.Duetothelimitedlong-termstabilityanewpolymersynthesisstrategywasadaptedusingthesameOs-complexbutprovidingenhancedcrosslinkingcapabilitiesbyintroducingepoxidefunctionsatthepolymerbackbone.Relatedbioelectrodesshowedenhancedglucose-dependentcurrentandastabilityofatleast3daysofcontinuousoperation.©TheAuthor(s)2014.PublishedbyECS.ThisisanopenaccessarticledistributedunderthetermsoftheCreativeCommons electrochemical measurements.— UV-Vis spectroscopy was used to evaluate the activity of PQQ-GDH. Spec- tra were recorded using a Specord S100 spectrometer (Analytik Jena, Germany). The procedure was following a protocol based on 3 measuring the change in absorption at a wavelength of 600 nm using DCIP as electron acceptor. Differential pulse voltammetry (DPV) of the Os-complex modi- fied EDPs was performed with an Autolab PGSTAT12 potentiostat (Eco Chemie, Utrecht, The Netherlands) controlled by the GPES 4.7 software (Metrohm, Filderstadt, Germany) in a three-electrode config-uration with a Ag/AgCl/3M KCl reference electrode and a platinum counter electrode. For Os649, Os650 or Os651 detection, a Pt-disk (1 mm in diameter) was used as working electrode in 1 M KCl so- lution after drop-coating the EDP. For P002-P54 detection, a drop of P002-P54 was placed on a 3 mm graphite electrode. After drying in air the modified electrode was used as working electrode in 0.01 M HEPES buffer containing 0.1% Triton (pH = 7). The potential was scanned from − 0.30 V to 0.45 V (all potentials are referred to Ag/AgCl/3M KCl reference electrode), with an amplitude of 0.05 V and a pulse width of 0.06 s. Cyclic voltammetry (CV) and chronoamperometry was performed with a conventional three-electrode system using a CHI 1030 electrochemical workstation (CH Instruments, Austin, Texas, USA) at a scan rate of 5 mV/s. Chronoamperometry was performed at an applied potential of 100 mV for the case of Os649, Os650, Os651 and 150 mV for P002-P54. Dynamic light scattering (DLS), static light scattering (SLS) and electrophoretic light scattering (ELS) measurements were done for


An optimal design problem is considered for a flexible-manufacturing system (FMS), which consists of a group of numerically controlled machines, automatic guided vehicles (AGVs) and an auto-storage. The processing times of materials (jobs) at each machine form a sequence of identically, independenly distributed (i.i.d.) random variables (r.v.s.). The transferring times of jobs by each AGV from the auto-storage to a machine or from a machine to the total storage also form a sequence of i.i.d.r.v.s. The decision variable is the number of AGVs in the system when the number of machines is fixed. We propose a method for obtaining a lower bound NL on the optimal numbers of AGVs under some important economic criteria which have been used extensively for optimal machining speed problems: This means that at least NL AGVs should be installed in the system. Some numerical examples are presented that demonstrate the practical usefulness of the proposed method.


In order to improve network intrusion detection precision, this paper proposed a network intrusion detection model based on simultaneous selecting features and parameters of support vector machine (SVM) by particle swarm optimization (PSO) algorithm. Firstly, the features and parameters of SVM are coded to particle, and then the PSO is used to find the  optimal features and SVM parameters by collaboration among particles, lastly, the performance of the model was tested by KDD Cup 99 data. Compared with other network models, the proposed model has reduced input features for SVM and has significantly improved the detection precision of network intrusion. DOI : http://dx.doi.org/10.11591/telkomnika.v12i2.3826


PURPOSE
To evaluate the accuracy of mechanical torque rachet types based on the number of uses.

METHODS
A total of 25 ratchets, including three frictional- and two spring-type torque ratchets from every mechanical torque ratchet group, were used in our study. A digital torque measurement device was used in assessing the efficiency of mechanical torque ratchets. All ratchets were tightened according to the torque values recommended by the companies. The ratchets were tightened 500 times in total.

RESULTS
Given the changes in torque delivery by the number of uses, a statistically significant torque loss was observed in the Bego ratchets (P< 0.05), and a statistically significant increase was found in the torque values of the other ratchet groups (P< 0.05). The highest increase in torque values was obtained in the MEDENTIKA ratchet group.

CLINICAL SIGNIFICANCE
This study showed that there are changes in the torque values applied based on the number of rachet uses. Thus, clinicians are advised to regularly evaluate the accuracy of the rachets.


Ten new diterpenoid representatives from the briarane skeletal class have been isolated from shallow water colonies of the Caribbean gorgonian octocoral Briareum asbestinum collected at Mona Island near Puerto Rico. The structures of the new secondary metabolites, named briareins C-L (3-12), were defined by chemical and spectroscopic methods. In addition, two known diterpenoids, briareins A (1) and B (2), were among the most abundant compounds isolated. Traces of another known diterpenoid, briarane methyl ester (13), were also isolated from the same gorgonian extracts. In this paper we also establish unambiguously structure 2 for the known diterpene briarein B.


In the article the etymology of the concepts «deviance» and «deviation» is considered. Articles of various dictionaries are analyzed. Intrinsic signs are allocated. Definition of considered concepts is formulated.


Elevated plasma high‐density lipoprotein (HDL), and its major constituent apolipoprotein AI (apoAI), are cardioprotective. Paradoxically, two natural variants of apoAI, termed apoAIMilano and apoAIParis, are associated with low HDL, but nevertheless provide remarkable protection against heart disease for heterozygous carriers and may even lead to longevity. Both variants arise from point mutations and have Arg173 and Arg151 to Cys substitutions, respectively, which allow disulphide‐linked dimers to form. Potentially, synthetic RNA/DNA oligonucleotides (chimeraplasts) can permanently correct single point mutations in genomic DNA. Here, we use a variation of such targeted gene repair technology, 'gain‐of‐function chimeraplasty', and attempt to enhance the biological activity of apoAI by altering a single genomic base to generate the atheroprotective phenotypes, apoAIMilano and apoAIParis.


s of the 47th Annual Meeting of the SENP (Société Européenne de Neurologie Pédiatrique)– Paris, March 22–23, 2019 Elisa Fazzi, President of SENP1 1Unit of Child Neurology and Psychiatry, Civil Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Italy Neuropediatrics 2019;50:e1. Dear Colleagues and Friends, On behalf of the board and of local organizing committee it is a pleasure to present the selected abstracts of the 47th Annual Meeting of the Société Européenne de Neurologie Pédiatrique (SENP). This year our meeting takes place in Paris, the historic cradle of our scientific society. The program is quite exciting and, in many aspects, innovative. The first day is focused on the effects of precariousness, environment and nutrition on brain, neurological problems in refugee, and migrant children ... The new challenges that our discipline need take into account and understand for the future. The interaction between the environment andgenetics plays a role in shaping thebrain. It is fundamental to underline the impact of poverty on cerebral development as it affects the health andwell-being of people through thenegative effects of stress experiences starting early in infancy. A poor environment has been linked to reduction in gray matter volumes, especially in the frontal and parietal areas, relatedwith executive function abilities; it also limits opportunities relevant to an optimal development, such as an exposure to a rich and varied language. Furthermore, the child is subjected to chronic stressors that can negatively affect neurobiological development. Therefore, it is important to promote prevention and early intervention programs, given thebrain plasticity exhibited in specific critical periods, such as childhood. The second day is going to be devoted to an update of neurological diseases which manifest in the neonatal period and in infancy. Themain issues in this field are related to new frontiers of cerebral reorganization and plasticity after brain damage and new techniques of exploration: neuroimaging, neurophysiology, and, last but not least, clinical aspects. In this critical period, such as the neonatal period and the first years of life, neurological signs change according to the infant's age and neurodevelopmental milestones, as well as the clinical approach of the pediatric neurologist, which is very subtle and competent and highly specific, typical of our discipline. The organizing committee, in particular Antoinette Gelot and François Rivier, our French board members are hosting us in the wonderful "ville Lumière" and we are very grateful for all their hard work. As usual in addition to invited lectures and satellite symposia, there will be free communications and posters. We are pleased to present here several selected, peerreviewed abstracts. We want to thank the invited speakers for sharing their valuable scientific competencies during the conference and to all our colleagues for attending it. The annual meeting of the SENP is an excellent opportunity to improve our scientific knowledge and exchange clinical and research experiences in a friendly atmosphere. Address for correspondence Elisa Fazzi, MD, PhD, Unit of Child Neurology and Psychiatry, Civil Hospital (ASST Spedali Civili), Piazzale Spedali Civili, 1 25123 Brescia, Italy (e-mail: firstname.lastname@example.com). © 2019 Georg Thieme Verlag KG Stuttgart · New York DOI https://doi.org/ 10.1055/s-0039-1685144. ISSN 0174-304X. Editorial e1 T hi s do cu m en t w as d ow nl oa de d fo r pe rs on al u se o nl y. U na ut ho riz ed d is tr ib ut io n is s tr ic tly p ro hi bi te d.


In this issue, Yamaji et al[1][1] report the very long-term (15-year) outcomes of patients treated successfully with balloon angioplasty (BA) compared with bare-metal stent implantation (BMS). Considering the major progresses made in interventional cardiology since the advent of BA, it would be


The purpose of this communication is to correct what I believe to be misconceptions concerning certain visual phenomena associated with strabismus by pointing to significant facts hitherto overlooked or disregarded. These misconceptions are so prevalent that their correction is of considerable importance. Of the misconceptions in question, probably the most misleading relate to anomalous projection. Before this remarkable phenomenon can be intelligibly discussed, it is essential that a precise definition of corresponding retinal points be given. Many such definitions have been attempted, some of which are evidently inaccurate, while others are inadequate or ambiguous.1The following definition, which, so far as I know, has never previously been definitely expressed, has certain advantages, particularly for the purpose of discriminating between normal and anomalous projection. With the head stationary, fix with one eye (for the present assumed to be the right) the center of any suitable object,A, as in


BiCMOS technolory has been ~ioven to be most effective for improving the performance of SRAMs. A sub 10"s access time has been reported in jl BiCMOS SRAM of IMeg bit density I] In addition to performance advantaaes. the availability of birk transistors in &CMOS technology has triggered an evolutibn of BiCMOS de"!" techniques for improving margin and minimining process sensitivity of Ultra Large Scale IC's. In this paper an Automatic Gain Control (AGC) circuit is discussed. This AGC circuit is applied to a high speed RiCMOS SRAM bitline scheme to control the bitline voltage swings BO that they are independent or temperature, operation and pmcess variations. Utilization of the superior small signal amplification eapabilitu of bioolar tranristor differential sense L~DB to directly coude


The Salisbury Court Theatre was the last London playhouse to be built before all theatres were closed by the Puritans in 1642. Although we know that the theatre was converted from a barn standing on a piece of property measuring 140 feet by 42 feet at a cost of ?1200,1 and we can now locate the property with some precision,2 there are no extant illustrations or descriptions of the interior of the Salisbury Court, as there are for its contemporary, the Cockpit-in-Court. As Oscar Brownstein points out, this playhouse may have represented the culmination of all previous private theatre experience, or it may have marked a major change in form or size from the other private theatres. "Though . . . these suggestions are interesting," says Brownstein, "they must remain insubstantial speculations until some better grasp of the physical features of the theatre can be found."3 While Glynne Wickham speculates that the Inigo Jones drawings held at Worcester College (Nos. 7B and 7C) might represent the Salisbury Court,4 there is no substantiation for this claim. In a recent article John Orrell suggests that this drawing represents the Phoenix, or Cockpit, in Drury Lane.5 While no firm conclusions can be drawn, it is far from certain that these drawings represent the Salisbury Court Theatre. The title of Edward A. Langhan's brief article in Theatre Notebook, "A Picture of the Salisbury Court Theatre,"6 seems hopeful but proves misleading, since Langhan speculates that the Lea and Glynne 1706 map of London contains by mistake a picture of a theatre known to have burned down some forty years earlier. In the absence of any acceptable illustrations or detailed descriptions of the interior of the theatre, the plays that were


The purpose of this study was to construct artificial intelligence (AI) training datasets based on multi-resolution remote sensing and analyze the results through learning algorithms in an attempt to apply machine learning efficiently to (quasi) real-time changing landcover data. Multi-resolution datasets of landcover at 0.51- and 10-m resolution were constructed from aerial and satellite images obtained from the Sentinel-2 mission. Aerial image data (a total of 49,700 data sets) and satellite image data (300 data sets) were constructed to achieve 50,000 multi-resolution datasets. In addition, raw data were compiled as metadata in JavaScript Objection Notation format for use as reference material. To minimize data errors, a two-step verification process was performed consisting of data refinement and data annotation to improve the quality of the machine learning datasets. SegNet, U-Net, and DeeplabV3+ algorithms were applied to the datasets; the results showed accuracy levels of 71.5%, 77.8%, and 76.3% for aerial image datasets and 88.4%, 91.4%, and 85.8% for satellite image datasets, respectively. Of the landcover categories, the forest category had the highest accuracy. The landcover datasets for AI training constructed in this study provide a helpful reference in the field of landcover classification and change detection using AI. Specifically, the datasets for AI training are applicable to large-scale landcover studies, including those targeting the entirety of Korea.


Populations of spiking neuron models have densities of their microscopic variables (e.g., single-cell membrane potentials) whose evolution fully capture the collective dynamics of biological networks, even outside equilibrium. Despite its general applicability, the Fokker-Planck equation governing such evolution is mainly studied within the borders of the linear response theory, although alternative spectral expansion approaches offer some advantages in the study of the out-of-equilibrium dynamics. This is mainly due to the difficulty in computing the state-dependent coefficients of the expanded system of differential equations. Here, we address this issue by deriving analytic expressions for such coefficients by pairing perturbative solutions of the Fokker-Planck approach with their counterparts from the spectral expansion. A tight relationship emerges between several of these coefficients and the Laplace transform of the inter-spike interval density (i.e., the distribution of first-passage times). 'Coefficients' like the current-to-rate gain function, the eigenvalues of the Fokker-Planck operator and its eigenfunctions at the boundaries are derived without resorting to integral expressions. For the leaky integrate-and-fire neurons, the coupling terms between stationary and nonstationary modes are also worked out paving the way to accurately characterize the critical points and the relaxation timescales in networks of interacting populations.


We present a combined or mixed method for the dynamic analysis of thin‐walled structures, based on the superposition of beam and shell strains and displacements. Polynomial or exact shape functions are used for the interpolation of the shell displacements, while discrete degrees of freedom are introduced instead of the generalized von Karman coefficients. Special attention has been given to the integration schemes, because of the combined beam and shell behaviour of the considered structures. The stability and accuracy of the four‐point integration scheme are studied by using the z‐transform. The method is applied to thin‐walled pipes and is also compared to the von Karman approach.


Information needs among children is interesting topic because the way they looking for information are difference with adult. Usually children require assistance from certain person to help them finding the right and valid information. In the case of street children who living in social institutions, social worker role is very important to help then finding information because most of street children have no formal education, so they need to directed at finding and retrieving information to develop their knowledge. The number of street children in Surabaya increasing every year, this condition forced Surabaya Social Service to implement appropriate strategies to reduce the problems related to street children. Ones were through the assistance from the Regional Technical Implementation Unit (UPTD) "Kampung Anak Negeri" staff in Surabaya. The aim of this research is to describe the role of social worker in developing information needs of street children in UPTD Surabaya. Data in this research was collecting using questionnaire. The research method is quantitative descriptive with total population (32 people) become respondent, consisting of all street children (15 children) and social worker (17 person) in UPTD "Kampung Anak Negeri" Surabaya. The result show that social worker in UPTD Surabaya have a potential role in developing information needs among street children, especially when they playing as facilitator and educator roles. Social worker support street children to find information that as many 9 (60%) street children mostly need information related to their hobbies (such as music, sports). Around 13 (76.5%) social workers provide an opportunity for them to disclose that information, and for more aware and independent in the process of finding information 12 (70.6%) social worker teaches street children a strategy to obtain appropriate information like visit the library or using the internet (with permission). According to 12 (70.6%) social worker, the ability of street children to finding information is still dependent on social worker role as facilitator and educator. But, the social worker role as community representatives and technical, become a supporting role for the success of finding information that street children needs..


During the preimplantation period, morphological and functional characteristics of the endometrium depend on the dual effects of hormonal action and the presence of the zygote. In this paper we attempt to demonstrate the possibility that spermatozoa also participate in the changes occurring during this period. Adult New Zealand rabbits were inseminated (50 X 10' sperm) via the abdominal route. One uterine horn (ES) was the experimental site, while the other served as control (EC) into which isotonic saline solution or C-75 Sephadex was injected. The animals were sacrificed at different times (from 0-12 h after insemination) and the uterus was removed. The endometrium was weighed and homogenized in the supernatant of 15,000 X g and the activity of isoenzymes B and C of carbonic anhydrase was determined. ES showed the following maximum enzymatic activities at 8 h postinsemination: isoenzyme B (0.70 ± 0.12) and C (2.72 ± 0.39) ; in (EC), B = (0.06 ± 0.01)' and C = (0.36 ± 0.05)'. In other experiments, the spermatozoa before insemination were preincubated at 37#{176}Cfor 30 mm in sialidase (5) or trypsin (T) to study the cell-cell (spermendometrium) effect. The endometrial response with (S) was 6 times higher than with (EC). (T) did not show any inductor effect. Carbonic anhydrase activation regulates the pH of uterine fluids and thus facilitates fertilization. The present paper indicates that spermatozoa in the uterus may be necessary for required increases in carbonic anhydrase activity. occurs without the gamete's participation as an inductor and that the sequence depends on molecules already present in the genital secretions of the female (Hicks and Rosado, 1975), which act on the recently arrived sperm. However, if this were true, capacitation would take place in a short time, perhaps in minutes. It is known that approximately 10 h are required for spermatozoa capacitation to take place in the uterus of the rabbit (Dukelow and Williams, 1967). This would be sufficient time to induce important metabolic and structural It is currently accepted that capacitation changes in the endometrial cells, as well as to produce a molecular response by capacitating


–  The different reproductive roles of the sexes can predict the direction and magnitude of sexual dimorphism of external and internal morphology. Males should have enlarged structures that enhance the acquisition of mating opportunities, whereas females are predicted to have enlarged organs that are associated with the production of eggs. We tested these predictions in male and female lake whitefish, a species in which both sexes have similar overall body size and shape. After controlling for body size, male lake whitefish had significantly longer jaws and pectoral and pelvic fins, larger hearts, and more muscle than females. Sexual dimorphism in relative muscle mass may be one of the most fundamental morphological differences between males and females. Females had relatively heavier livers than males. Because the liver is important for the breakdown of fats and vitellogenesis, selection should favour an enlarged liver in females for the processing of energy and the production of large numbers of eggs.

Resumen

1. Los diferentes papeles reproductivos de los sexos pueden predecir la direccion y magnitud del dimorfismo sexual en la morfologia externa e interna. Los machos deberian tener estructuras mayores que estimulen la adquisicion de pareja mientras que las hembras deberian tener organos mayores asociados a la produccion de ovulos. Examinamos estas predicciones en machos y hembras de Coregonus clupeaformis, una especie en la que ambos sexos tienen formas y tamanos similares.

2. Los machos exhibieron mandibulas y aletas pelvicas y pectorales significativamente mas largas, corazones mas grandes y mas musculo que las hembras. Dimorfismo sexual en la masa muscular relativa puede ser una de las diferencias morfologicas fundamentales entre machos y hembras. Las hembras tuvieron higados mas pesados que los machos. Dado que el higado es importante para el metabolismo de las grasas y para la vitelogenesis, la seleccion deberia favorecer mayores higados en las hembras para procesar la energia y para la produccion de mayores numeros de ovulos.


In general, schools in eastern Agam Regency have not yet making use optimal computer technology in learning process. Furthermore, limited innovation has been made dealing with the limitation of chemical laboratory work materials. To answer the problem, training on making use of ICT in Chemistry subject and manipulative skill laboratory equipments for Chemistry teachers throughout eastern Agam Regency was conducted. Kata kunci: ICT, manipulative skill, laboratory


Over recent years, various exact cone-beam reconstruction algorithms have been proposed. The derivations of these algorithms are quite complicated, and often difficult to see the fundamental connections among these methods and their key steps. In this paper, we present a straightforward perspective based on the Fourier transform, which is a universal principle for parallel and divergent beam computed tomography (CT). The formulas in this paper are not only consistent with the latest findings in the field but also valid under more general conditions.


Received: 27 November 2017 Accepted: 20 July 2018 The present work proposes an analytical investigation on the energetic and exergetic performance of an air heating solar collector having absorber surface equipped with fins and twisted tapes of twist ratio Y=2,4,6 and 8. A mathematical model capable of predicting the energy and exergy efficiency has been developed. The effects of mass flow rate, twist ratio and insolation on the thermal and exergy efficiency have been studied. Further, a comparison has been made with the results of smooth absorber solar air heater to check the performance enhancement over it. The results indicated that the thermal efficiency increases monotonically with increase in air flow rate but the exergy efficiency curve first goes up, achieves its maxima and then declines. Decrease in twist ratio from Y=8 to 2 leads to improvement in the thermal efficiency for whole range of studied mass flow rate but enhancement in the exergy efficiency was observed only up to the mass flow rate of 0.022 kg/s thereafter it starts decreasing.


We present results on L estimates for solutions of ∂̄-equations on a Stein manifold with a divisor. The structure of the divisor allows us to introduce weights with certain types of singularities, and the geometry of the manifold near the divisor allows us, by exploiting twisted techniques, to weaken the usual curvature hypotheses that guarantee a solution. We investigate two situations; one in which the weights are not locally integrable, and another in which they can be. Dedicated to John D'Angelo, who really enjoys life in a suspended fourth.


Chester Robinson, PhD (1956–2021) served as Executive Editor from 2004–2007, following a three-year tenure as Managing Editor. Under his leadership, the Journal of Professional Counseling: Practice, Theory & Research won the Best Branch Journal Award from the American Counseling Association. Shortly thereafter, Dr. Robinson transitioned the Journal of Professional Counseling: Practice, Theory & Research from a small branch publication to a nationally recognized professional journal. The editorial board grew to 16 members with as many as 8 editors hailing from across the United States. He was especially proud to have the journal abstracted and indexed by EBSCO and assigned an ISSN number by the Library of Congress during his tenure as Executive Editor. Dr. Robinson not only launched our national journal but also created opportunities for counselor educators across Texas to publish their research and build their publication skills. Many who served under Dr. Robinson have gone on to serve as Executive Editors of several national and international counseling journals. The Journal of Professional Counseling: Practice, Theory & Research is a well-recognized resource for the latest and best interventions, practicerelated research, and theories and models that have applicability across all counseling specializations as a result of the strong foundation built by Dr. Robinson during his tenure as Executive Editor. His passion for the counseling profession and high ethical standards were evident throughout his career. JOURNAL OF PROFESSIONAL COUNSELING: PRACTICE, THEORY & RESEARCH 2022, VOL. 49, NO. 1, 60 https://doi.org/10.1080/15566382.2022.2088224


The author calculated that the body of a man weighing 75 kilograms contains 1) enough fat to make three candles, 2) enough water to wash two sheets, 3) enough iron for a pinky nail, 4) enough lime to whitewash a small room, 5) enough sulfur to kill fleas in a sick dog, 6) enough sugar for morning tea.


Aim: To examine the relationship of physical activity levels and physical fitness components with overweight and obesity in adolescent boys. Method: We recruited 332 school going boys of age 13-18 years as subjects. The subjects filled a validated questionnaire: Physical Activity Questionnaire-A (PAQ-A) to report their physical activity levels. They were further subjected to the testing of their physical fitness components including speed, explosive power, flexibility, agility, endurance, coordination, balance, handgrip strength and reaction time. The relationship between these variables and overweight and obesity were examined by applying the Point-biserial correlation test. Results: The prevalence of overweight and obesity was 5.42% and 1.51% respectively. Significant correlations were found between the body mass index (BMI) status of adolescent boys and their physical activity levels and overall physical fitness status. Conclusion: Overweight and obese adolescent boys had inferior levels of physical activity and physical fitness profile than the non-overweight and obese boys.


Maternal obesity is a growing health concern that has previously been associated with increased need for induction of labour (IOL) and caesarean section (CS) rates. Currently, limited evidence explores the influence of maternal body mass index (BMI) on Bishop Score (BS) and outcome of IOL. This study hypothesises that maternal obesity will lead to a lower BS at presentation, higher rates of failed IOL, and increased CS rates.


According to one embodiment, the electrode comprises a current collector and containing an active material layer. The layer comprising the active material comprises a first layer and a second layer. A first layer on a surface of the collector is provided and includes a lithium titanium oxide having a spinel structure. A second layer provided on the first layer, and including monoclinic β-type titanium composite oxide.


· Abstract An analysis of the short-period and tidal sea-level variations is performed based on the measurements taken at the stations along the coasts of the Southwestern Black Sea, Strait of Istanbul (Bosphorus), Sea of Marmara, Strait of <;:anakkale (Dardanelles) and Northeastern Aegean Sea. Short-period oscillations observed on the records were related to the natural periods of the straits and the Sea of Marmara itself. Tidal oscillations are small in amplitude and tidal regimes change along the Turkish Strait System.


Author(s): Davidson, Alec | Advisor(s): Asker, John | Abstract: This thesis consists of three chapters, each dealing with a topic that relates to the effects of government regulation on agent behavior and social outcomes. The first chapter examines the role of government policy in encouraging the proliferation of residential solar panels in California between 2009 and 2016. It examines the extent to which a policy known as net-metering served as an indirect subsidy to households that chose to install solar panels, and predicts the effects of removing that policy on demand. To do so I formulate a model of consumer demand for solar panels and estimate it using a moment inequality technique. I use the results of this estimation to run a counterfactual analysis on the effects of removing net-metering. My results indicate that the complete removal of net-metering would have resulted in about 40\% less solar being installed over the relevant time period. The second chapter is joint work with Pavel Anreyanov and Vasily Korovkin. It covers corruption in Russian government procurement auctions. Specifically, we examine a scheme whereby government auctioneers reveal information about participants bids to their preferred candidate in sealed bid auctions. We estimate the extent of this behavior in a data set of auctions spanning a variety of industries and locations between 2011 and 2016. We find substantial evidence of corruption: in total about 10\% of the auctions we observed exhibit evidence of corrupt behavior. The total value of these affected auctions was about \$1.2 billion. The third chapter is a examination of the theoretical implications of state-mandated network neutrality. Network neutrality is the informal name for the policy that restricts the ability of Internet Service Providers to control how much bandwidth is allocated to different users. I demonstrate the possibility, that under certain assumptions, there exist scenarios where a no-network-neutrality policy is welfare superior to the setting with network neutrality. My approach is centered around the ability of certain large bandwidth users to impose an externality on other users by hogging the available space. I find that either charging these high usage participants or restricting the amount of bandwidth they can utilize simultaneously, welfare can be improved.


Abstract: Background: Endothelial dysfunction is a common finding in renal transplant recipients (RTR) and is related to impaired local regulation of vasodilative and vasoconstrictive substances, such as nitric monoxide (NO) and endothelin‐1 (ET‐1). In non‐transplanted patients, an association between impaired endothelial function and insulin resistance has been shown. Whether such an association also exists in RTR is unknown.


The emotive issue of abortion is once again in the news as Nadine Dorries MP seeks to include an amendment in the Health and Social Care Bill about organisations who are permitted to counsel women seeking abortions. Emily Jackson discusses the proposed amendments and its aim of reducing the number of abortions taking place each year.


This paper reviews advanced-economy productivity developments in recent decades. We focus primarily on the facts about, and explanations for, the mid-2000s labor-productivity slowdown in large European countries and the United States. Slower total factor productivity growth was the proximate cause of the slowdown. This conclusion is robust to measurement challenges including the role of intangible assets, rankings of productivity levels, and data revisions. We contrast two main narratives for the stagnating productivity frontier: The shock of the Global Financial Crisis; and a common slowdown in productivity trends. Distinguishing these two empirically is hard, but the pre-recession timing of the U.S. slowdown suggests an important role for the common-trend explanation. We also discuss the unusual pattern of productivity growth since the start of the Covid-19 pandemic. Although it is early, there is little evidence so far that the large pandemic shock has changed the slow pre-pandemic trajectory of productivity growth.


The foundation as the theme of political philosophy has turned its attention to the problem of the principle. This is a phenomenon that is recorded since the legendary narratives of antiquity. Hannah Arendt conceives the analysis of the Revolutions as foundation, addressing this relationship from the idea that the foundation is developed through this novelty introduced in the context of the eighteenth century. Thus, the theme of the foundation, discussed by Arendt under the light of the events of the American and French Revolutions, is crucial and has relevant aspects, because it places us in front of the problem of the novelty. The objective is to address the phenomenon of revolution as foundation demonstrating that wars do not have the purpose of being an unprecedented novelty, for this purpose has been provided by the events in France and the United States. We intend, therefore, to explain the purpose of the phenomenon of the Revolution as the foundation of freedom.


Ambiguous appearance discrimination plays an important role in the impurity detection task. Among the majority of deep learning models, images from every sequence are processed separately instead of being considered collectively. Therefore, the outputs of these models given a single region proposal might not be accurate. In this paper, a gallery-guided graph architecture is proposed and integrated to overcome such limitations. Specifically, region proposals are firstly generated using a two-stream fusion network; then their feature embeddings are extracted from a convolutional neural network by reducing intra-class variations while increasing inter-class ones. Secondly, a graph representing clusters among different training sequences updates relationships between region proposals in the test sequence. Finally, the features of the graph are classified by a graph convolutional neural network. Different from those learned weights in conventional common object detectors, region features from all the training sequences are explicitly integrated into a gallery-guided graph architecture. Extensive experiments on IML-DET dataset demonstrate that our proposed method can obtain competitive performances compared with previous state-of-the-art object detection approaches transferred into this task.


The study was conducted to evaluate arhar and gram straw based pelleted complete feed. Non descript local goats (18; 320 d old of 21.8 ± 0.8 kg BW) divided into 3 equal groups were offered complete feed pellets based either on arhar straw (ASCF) gram straw (GSCF) or exclusive arhar straw pellets supplemented with concenrate pellets (AS-CONC) for 110 days. The roughage to concentrate ratio was maintained at 60:40 in all the diets. The DM and CP intake (as % BW) was comparable between ASCF and GSCF but was improved (P<0.01) in AS-CONC diet. The digestibility of most of the nutrients (OM, CP and EE significantly) was higher in goats fed gram straw based pelleted complete feed. The significantly (P<0.01) low NH3-N and NPN content in the rumen liqur of goats fed AS-CONC diet were responsible for higher (P<0.01) TCA-N as compared to other groups. The gram straw based complete feed pellets had highest (P<0.01) DCP content compared to other diets, but the TDN content was comparable in all groups. The goats under all the treatments were in positive nitrogen, calcium and phosphorus balance. The daily live weight gain was considerably higher in goats fed gram straw based pellets. It was concluded that goats fed on gram straw based pelleted complete diet performed better and fulfills the requirement of goats growing at 108 g per day under stall fed condition.


Nowadays the application of Android-based media is currently a trend in science education research. In the subject of Invertebrates, there can be found terms use the Latin or scientific language. Students are having difficulty in following the materials of invertebrates, especially in understanding the terms of invertebrate's body structures. This research aims to know the effect of the implementation of Android-based biology dictionary on invertebrate's subject topic to improve student's learning motivation. Questionnaire is used as instrument in this research. This research used the pretest-posttest control group design. The subject was XI Grader of SMAN 2 Bantul consisted of an experimental class and a control class. The gain scores were analyzed to know the improvement of student's learning motivation. The result shows that Android-based illustrated biology dictionary is able to provide significant effect towards the improvement of student`s learning motivation.


Eliade proposed to 'undertake to analyze the religious creativity of modern societies' in his History of Religious Ideas but never did so. In this paper I have attempted to suggest the general direction that his analysis would have taken – the identification of the real with the actual is a religious valorization of contemporary humanity. This is not a generic shift from religion to non-religion but a belief of a religious nature which constitutes a novel departure from the traditional operations of the religious mind. It is accompanied by a refusal to countenance our creative involvement in the construction of reality. This Eliade labels 'modern' and 'historical'.


To improve the method of selection of the service mode for medical equipment in Class A Tier 3 hospitals,an assessment system is designed based on the analytical hierarchy process and the weight of relevant criteria is calculated in this paper.


A kind of medical experiment arrangement arrangement problem,which was a constrained optimization was solved by using an improved Simulated Annealing algorithm based on Hierarchical Fair Competition Model(HFCSA) through modifying the definition of individual,designing new coding method and growth pattern,and proposing efficient operators.The results show that the time expense of the new optimal solution is 77% of the older one.The success to solve medical experiment arrangement problem has widened the HFCSA's application field and found out a new way for solving some similar constrained optimization problems.


Arguments are presented to support the barrier-cluster model of non-crystalline semiconductors. It turns out that several experimental facts and from the field of optical phenomena can be explained successfully using this model complemented by the idea that free electrons in a non-crystalline semiconductor stimulate non-radiant recombinations. The article presents new, as well as earlier published facts in favour of this model.


Implementation of the pilot project «Inpatient unit of emergency medicine» in a multidisciplinary hospital resulted in enhancement of indicator values of multidisciplinary hospitals of emergency medicine. The rate of unjustified hospitalizations in the share of short-term patients hospitalized in specialized subdivisions was reduced from 22.32% to 19.07% (p<0,05). It has been revealed a reduction in the number of patients by 1,82 times with the diagnosis-marker «S06.0 Cerebral Contusion» which were treated in the neurosurgery department up to 3 days of stay in hospital. It was identified an increase of frequency of medical care at emergency department by 17,81% (from 833,53 in 2012 to 981,98 in 2015 for 100 cases of medical resource utilization). Achieved changes gave rise to increase of admission capacity by 11,0% within 2013-2015 due to increase in the number of out-patient cases (15,26% to 27,71%) and reduction in the number of hospitalized patients (84,74% to 72,29%).


Recently, Device-to-Device (D2D) communication has been under discussion with great attention. In particular, D2D discovery, as the first step of D2D communication, is a matter in dispute. In this paper, we propose a novel D2D discovery protocol to significantly reduce the participation delay, i.e., the time duration from the user's entrance into the network to the first beacon transmission, compared with the existing protocols incurring long participation delay. For the verification of our work, we evaluate our work via both mathematical analysis and simulation. Through our thorough investigation with a few resource selection algorithms, we observe that our proposed scheme reduces participation delay by 66% and that it barely degrades the performance in guaranteed distance among users which share the same resource.


Electronic apparatus according to the embodiment, as an example, comprises a housing, a touch pad unit, a supporting portion, an operation portion, and the reinforcing member. The housing opening is provided. Touchpad unit is exposed from the opening, has an operation surface, it detects an operation on the operation surface. Supporting portion is configured in a plate shape, it is supported by the housing displaceably supporting the touch pad unit. Operation unit is pushed along with the displacement of the touch pad unit. The reinforcing member is constructed in a plate shape, is fixed in a state overlapping the touch pad unit or support unit comprises a hard material than the support portion.


Remote sensing(RS) based soil moisture reversion is original and tentative for topographical survey and analysis in exposed tidal flat where this area is strongly affected by tidal fluctuation.The spatial distribution of soil water content is also highly helpful for deep level cognition and comprehension of the ecological environment there.So taking experiences from land phase soil property research,a soil moisture reversion model was established based on the correlation analysis between in situ soil water content and its relevant RS spectrum data using Landsat ETM+ image in an intertidal flat area near Wanggang Port,Jiangsu Province,China.And then the model was applied for soil moisture reversion with good precision.Results showed that:(1) spectral reflectance of ETM+ Band 4 has the maximum correlation with soil moisture in tidal flat;and(2) compared with different models such as multivariate linear model,single band,band-ratio and pseudo-NDVI model,single band model has the minimum error for soil moisture reversion.It was indicated that the distribution of soil water content in the exposed intertidal flat could be quickly and conveniently obtained by the model when the appropriate RS image was available.


The moment method is applied to calculate and study the induced current distribu tion, far scattering held, and near field distribution of perfectly conducling cylinders with various cross sections for incident E-plane wave.The calculated results are in good agreement with analytical solutions and experimental results.


Objective To investigate the expression of two different RASSF1 transcripts and its clinical relations with the glioma pathology.Methods The mRNA expression of RASSF1A and RASSF1B was detected by RT-PCR method in 46 specimens of brain glioma and 6 normal brain tissues.Results The expression of RASSF1A and RASSF1B was complete in six normal brain tissues。The rates of expression loss of transcripts A and B in glioma were 47.8 %(22/46)and 26.1%(12/46)。The mRNA expression level of RASSF1A was significantly lower in gliomas than in normal brain tissues.The rates of expression loss of RASSF1A and RASSF1B mRNA had no signifcant relation with differentiation stage and pathological histology of gliomas.Conclusion There is a significant difference in the expression between the two different RASSF1 transcripts of A and B in the brain gliomas,and normal brain tissues.It is important to detect the rate of expression loss of RASSF1A in the glioma.


Abstract : Diabetes mellitus type 2 is caused by insulin resistance, thus it produces hyperglicemia (blood glucose > 126 mg/dl) and usually occurs in weight more than normal (Soeparman, 1991; Christine, 2002). The exercise is an activity which is useful for diabetic as it can reduce blood glucose. When exercising, the body needs energy which is mostly obtained from glucose in body. While exercising, there is enhancement of power needs. Therefore, the glucose level in body will reduce because of that activity. The exercise is useful to the body is not just any sport activities, it can be said useful if there is achievement of target pulse, it does not seen from fatigue which is felt or amount of sweat that is produced. When the pulse to be achieved can stimulate organ function, the body will always respond each burden and accustomed with FITT (frequency, intensity, time and type), in terms of frequency 3 times a week, aerobic intensity 60-70% DNM, time 20-30 minutes, and type; jogging, run and other types of exercises (Wiarto, 2013). The advantage of exercise is to control blood-glucose, enhance high-quality cholesterol level (HDL), lose weight, improve musculoskeletal symptoms, improve quality of life, and prevent the occurence of diabetes mellitus. If the exercise is concucted appropriately, thus the indicator of its success is fasting blood glucose 80 to < 100 mg/dL, blood glucose after meal 80 to <145 mg/dL, HbAlc < 7%, LDL < 100 mg/dL, HDL for men ≥ 40 mg/dL, for women ≥ 50 mg/dL, trigliserida < 150 mg/dL, total cholesterol < 200 mg/dL, and blood pressure is 120/80 mmHG (Suryono E, 2013)).


According to the roles of ring beam acted in preservation structures of foundation pit finite element model is established.Reasonable hypothesis is proposed for calculation.Combined with practical work utilizing ANSYS numerical simulation analysis is made on preservation structure with or without ring beam and the situations with various rigidities.The internal force and deformation status of ring beam and retaining pile are discussed.Analysis show the deformation of retaining beam reduces with increase of the rigidity of ring beam.