Today, knowledge is considered as a competitive advantage. So, different countries try to prepare necessary infrastructure for knowledge development in different levels. One of the solutions in this field especially for know-how development is establishing physical places with purpose of doing knowledge based projects. These physical places were established in different countries with various names like scientific parks, technopolis, hi-tech zones and so on. Regarding to the necessity of establishing these places, some efforts have been done in this way. Identification of scientific and technology park objectives and also investigation of their focused fields are very essential for policy making in future. Thus, it is tried in this research to investigate the objectives and functions of Iranian science and technology parks. Also by a national survey, importance of various stages of innovation was elicited. Finally, for improving performance of these institutions some solutions have been presented.


The invention belongs to the technical field of environmental protection and discloses an environmental-protection process for purifying the tail gas in production of amino acid. The environmental-protection process comprises the steps of removing dust and mist, desulfurizing, denitrating and preparing fertilizers. The environmental-protection process disclosed by the invention has the advantages that the operation is simple and feasible, the investment cost is low, and the treating effect is good; and the fertilizers are utilized and prepared simultaneously, so that the purpose of changing wastes into valuables is realized and two purposes are achieved by one action.


Constructions of spaces from symmetric monoidal categories or $\Gamma$-categories are typically functorial with respect to strict structure-preserving maps, but often the maps of interest are merely lax monoidal or lax natural. We describe conditions under which one can transport the weak equivalences from such a category of structured objects and strict maps to the corresponding category with the same objects and lax maps. Under mild hypotheses this process produces an equivalence of homotopy theories. We describe examples including algebras over an operad, such as symmetric monoidal categories and $n$-fold monoidal categories; and diagram categories, such as $\Gamma$-categories.


During the 1960s and 80s the author was carrying out the case studies of continental upper Mesozoic deposits of intermontane isolated basins of Transbaikalia. Great amount of facts (in the form of unpublished reports) was collected. This article is the beginning of the publications on new data on the problems of upper Mesozoic deposits in the region.The upper Mesozoic of ust-Kara basin differs from the other ones by its characteristics of cyclical stratigraphy, the dominance of psephites in the base of cyclites, by the mix of Late Jurassic species-indexes of unda-Daya complex and Jurassic-Cretaceous species of Turga complex in the presence of special conchostraca-Defretinia (layers with Defretinia).This is single occurrence with the remains of Notostraca -triopsi, fossil birds (feather) and unique gieroglyphs in the region. Key section of ust-Kara suite in the vicinity of ust-Karsk village, particular sections along the Kara, the Zheron, the Luzhanky rivers, and the section of Turga suite of the Polosatik Rock are described by the author. For the first time the author gives the reconstruction of ust-Kara volcanic lakes on the alluvial fans and the wide Turga Lake outside the volcanic zone. The addition of stratigraphic and paleontological characteristics of ust-Kara suite which is allocated as a transitional horizon between unda-Daya and Tugra suites, as well as Turga suite itself is examined here.


Foreign policy analysis (FPA) opens the "black box" of the state and provides explanations of how and why foreign policy decisions are made, which puts individuals and groups (from committees to ministries) at the center of analysis. Yet the sex of the decision-maker and the gendered nature of the decision-making process have generally been left out of the picture. FPA has not addressed questions regarding the influence of women in foreign policy decision-making processes or the effects of gender norms on decision-making; indeed, FPA appears to be almost entirely gender-free. This article argues that "gendering" FPA is long overdue and that incorporating gender into FPA frameworks can provide a richer and more nuanced picture of foreign policy–making.


Conventional rf guns such as the BNL/SLAC/UCLA 1.6-cell gun require a high operating peak field typically above 120 MV/m. By contrast, the PWT gun can operate at a much lower peak field with excellent beam properties. A 10+2(1/2)-cell PWT photoinjector can achieve an emittance of 0.56 mm-mrad for a 1 nC bunch charge at a peak field of 55 MV/m; and 1.04 mm-mrad for 2 nC at 60 MV/m. By operating the PWT gun at a low peak field, dark current production from back bombardment of electrons emitted elsewhere in the rf cavity is mitigated as the number of electrons which could back stream to hit the photocathode and the cathode holder is significantly curtailed. The quantum efficiency and lifetime of a semiconductor photocathode, such as GaAs are significantly improved if the surface of the cathode is subjected to a lower peak field.


Kinesin-1 is a nanoscale molecular motor that walks towards the fast growing (plus) ends of microtubules (MTs), hauling molecular cargo to specific reaction sites in cells. Kinesin-driven transport is central to the self-organisation of eukaryotic cells and shows great promise as a tool for nano-engineering1,2. Recent work hints that kinesin may also play a role in modulating the stability of its MT track, both in vitro3-5 and in vivo6, but results are conflicting7-9 and mechanisms are unclear. Here we report a new dimension to the kinesin-MT interaction, whereby strong-state (ATP-bound and apo) kinesin-1 motor domains inhibit the shrinkage of GDP-MTs by up to 2 orders of magnitude and expand their lattice spacing by ~1.6%. Our data reveal an unexpected new mechanism by which the mechanochemical cycles of kinesin and tubulin interlock, allowing motile kinesins to influence the structure, stability and mechanics of their MT track.


A neural network architecture able to autonomously learn effective disparity-vergence responses and drive the vergence eye movements of a simulated binocular active vision system is proposed. The proposed approach, instead of exploiting purposely designed resources, relies on the direct use of a set of real disparity tuning curves, measured in the primary visual cortex of two macaque monkeys and courteously made available by (Prince et al., 2002), that provides a distributed representation of binocular disparity. The network evolves following a differential Hebbian rule that exploits the overall population activity to measure the state of the system, i.e. the deviation from the desired vergence position, so as its modification as a consequence of the action performed. Accordingly, the signal provides an effective intrinsic reward to develop a stable and accurate vergence behaviour. Emerging from a direct interaction of the sensing system with the environment, the resulting control provides a precise and accurate control for small disparities, as well as a raw control on a broader working range when large disparities are experienced. The developed control converges to a stable state that intrinsically and continuously adapts to the characteristics of the ongoing stimulation. The results proved how actually naturally distributed resources allows for robust and flexible learning capabilities in changeable situations.


The author describes the NLQ approach to information retrieval from databases in the context of natural-language interfaces (NLIs) in particular and interfaces to database-management systems (DBMSs) in general. NLQ, a personal computer-based natural-language query system to relational databases, embodies three characteristics for database interfaces of the future: (1) the ability to interface to different DBMSs on various hots, (2) the ability to manipulate data retrieved from the DBMS in other software packages (e.g. spreadsheets), and (3) the facility for the end-user to customize his own interface.<<ETX>>


BACKGROUND
Microorganism for biological control of fruit diseases is an eco-friendly alternative to the use of chemical fungicides.

RESULTS
This is the first study evaluating the electrospraying process to encapsulate the biocontrol yeast Meyerozyma caribbica. The effect of encapsulating material (Wey protein concentrate (WPC), Fibersol® and Trehalose), its concentration and storage temperature on the cell viability of M. caribbica, and in vitro and in vivo control of Colletotrichum gloeosporioides was evaluated. The processing with commercial resistant maltodextrin (Fibersol®) 30% (w/v) as encapsulating material showed the highest initial cell viability (95.97 ± 1.01%). The storage at 4 ± 1 °C showed lower losses of viability compared to 25 ± 1 °C. Finally, the encapsulated yeast with Fibersol 30% w/v showed inhibitory activity against anthracnose in the in vitro and in vivo tests, similar to yeast fresh cells.

CONCLUSION
Electrospraying was a highly efficient process due to the high cell viability, and consequently, a low quantity of capsules are required for the postharvest treatment of fruits. Additionally, the yeast retained its antagonistic power during storage. This article is protected by copyright. All rights reserved.


Antiferromagnets (AFMs) are a ubiquitous class of magnetic materials, holding the promise of low-dissipation spintronic computing devices that can display ultra-fast switching, density scaling and robustness against stray fields1. However, magnetic sublattice compensation makes it difficult to detect and control AFM textures in a reversible and scalable manner via standard techniques2. We overcame this limitation by developing a novel ionic approach to reversibly tailor AFM anisotropy3. We focussed on the earth-abundunt AFM α-Fe2O3, which exhibits a spin-reorientation (Morin) transition between in-plane and out-of-plane configurations. Developing reversible control of AFM anisotropy in α-Fe2O3 is important for prospects in (i) topological spintronics4,5 and (ii) magnonics6,7. Regarding the former, I will discuss our recent results where the Morin transition was exploited to stabilize a wide family of exotic AFM topological textures half-skyrmions and bimerons at room temperature. These topological textures have core sizes (of ≈ 100 nm) and can be scaled further with anisotropy tuning4. In this context, I will discuss our findings on ionic control of antiferromagnetism in epitaxial α-Fe2O3 films3. The catalytic-spillover process employs Pt nano-structures to hydrogenate the AFM films, thereby, driving pronounced changes in the anisotropy, Néel vector orientation and canted magnetism via local charge-doping. As H ions are very small and light, they can be added/removed from the host lattice, without significantly disturbing the overall structure. This allows our approach to be stable yet reversible3. Tailoring our work for future applications, we demonstrated reversible control of the room-temperature AFM-state by doping/expelling H ions in Rh-substituted α-Fe2O3. I will conclude by presenting the wider implications of our work, such as how AFM-state control could eventually be realized with E-fields8 and translated to a wider variety of AFMs (e.g. orthoferrites, orthochromites)9, enabling the construction of low-energy antiferromagnetic applications. References: [1] Baltz, V et al. Rev Mod Phys 90, 015005 (2018); Wadley, P et al. Science 351, 587 (2016) [2] Cheng, S et al. Nanotechnology 29, 112001 (2018) [3] Jani, H* et al. Nat Commun 12, 1668 (2021) [4] Jani, H* et al. Nature 590, 74 (2021) [5] Chmiel, F P et al. Nat Mater 17, 581 (2018) [6] Lebrun, R et al. Nature 561, 222 (2018); Lebrun, R et al. Nat Commun 11, 6332 (2020) [7] Han, J et al Nat Nanotechnol 15, 563 (2020) [8] Tan, A J et al. Nat Mater 18, 35 (2019) [9] Afanasiev et al. Phys Rev Lett 116, 097401 (2016); Hornreich et al. Phys Rev B 12, 5094 (1975)


This paper investigates comparative advantage and structural changes across Manufacturing Industries in Yazd Province between 2000 and 2007. In doing so, we calculate the Balassa index of revealed comparative advantage using industry data at the 2-digit levels and evaluate the industrial specialization patterns of the Yazd province in terms of value added and employment factors. The results indicate that structural changes no perfectly align with comparative advantage. The results of estimation reveal the fact that the industrial specialization patterns of Yazd province has been convergence at the 2-digit level.


One of the classic examples of a fluid mechanical bifurcation is the appearance of Taylor vortex flow in a viscous fluid contained between concentric rotating cylinders. A natural consequence of the mathematical model due to D. G. Schaeffer, which has been most successful in describing this phenomenon in a finite system, is the presence of 'anomalous modes' in the steady solution set. These are cellular flows that exist in contradiction to the commonly held belief that the radial flow close to the ends is necessarily directed towards the inner cylinder because of the presence of an Ekman boundary layer. To date anomalous modes have only been studied in a restricted parameter range, but here we report the results of numerical and experimental studies that cover a wide range of parameter space. It is shown that the lower stability limits for anomalous modes are removed to high Reynolds numbers when the gap between the cylinders is reduced. This perhaps explains why this class of flow remained undiscovered in over fifty years of study of the Taylor─Couette problem until the work of T. B. Benjamin. We also consider the implications of these results for the organization of dynamical behaviour in the Taylor─Couette system.


In the current study, the intertidal amphipod assemblages of two Iranian Islands which includes Qeshm ,  as an Island near to mainland, and Abu Musa, as an Island far from the mainland. The sampling is down in eight stations in each Island from 2013 to 2016. Results show that the amphipod assemblages of Abu Musa  and Qeshm islands were composed of 8 species from 8 genera and 5 families and 11 species from 11 genera and 6 families, respectively.  The record of the Glossomaera octodens (Sivaprakasam, 1968) is new for the western part of the Indian Ocean. There were no differences in taxonomic indices between islands. However, both islands showed similar average taxonomic distance with greater variation in taxonomic distance and species richness [a1] of Qeshm  compared with Abu Musa, primarily because of .greater   variation in habitats in the former. The better environmental conditions in Abu Musa caused higher abundance per species then in Qeshm. The results of the present study add two species to previous reports of the Abu Musa Island and produce first comprehensive listed record of amphipods in the Qeshm Island, including new species record.


Stephen M [Martin] Saxby, was hired by the British Admiralty as an acting Naval Instructor to instruct junior officers and engineers at the Chatham naval base. He lived on the HMS Devonshire, Sheerness UK, from 1858 to 1865. He was interested in the formation of storms and weather forecasting and he came up with a theory that was totally erroneous. He believed that the declination of the moon, north or south of the equator, influenced the formation of storms and hurricanes.
 A letter from Saxby to Dr George Fordyce Story dated 1865.
Saxby writes about his third son, Gordon Harding Saxby's visit to friend Mr Meredith during the time of the great flood on 14th December. He was staying with Sir Richard Dry at Quamby Hall on Tasmania's East Coast prior to leaving for New Zealand.
 He thanks Story for his weather register, and comments that many lives that had been saved through his meteorological observations. He also mentions his second son Henry Linkmeyer Saxby (Doctor and ornithologist) and father-in-law , Dr Laurence Edmondston (Doctor and well respected amateur naturalist, who built Halligarth on Unst, now owned by the National Trust for Scotland). From Cotton Family Papers C7/176


OBJECTIVE To study the clinical characterization,the layering diagnosis and treatment about invasive aspergillosis in the children hematological diseases and malignant tumor.METHODS A total of 26 children with invasive aspergillosis were analyzed.The patients with dangerous factor would carry on complete first,experience and aiming at treatment.To carry on date processing by SPSS 10.0 statistics software.RESULTS There were 26 cases for the invasive aspergillosis.5 cases among them were diagnosed.The others were probable and possible.9 cases were dead and 17 cases were survival,The WUVH was adopted for the first time in children in China.The score was over 15.The 26 cases had no characteristic.The positive rates of Halo sign and air-crescent sing were 23.08% and 29.62%,respectively,GM of 22 cases were positive.Survival rate of voriconazole group was 91.67%.Survival rate of fluconazole +AmB group was only 50.00%.CONCLUSIONS Identifing the people with dangerous factor in early as possible,such as host,clinical characterization,microbiology and organization pathology be advantageous to diagnose.The layering diagnosis and treatment can benefits the patients.The choice of reasonable medicine is effectively to reduce the mortality.


Objective To establish efficacy and safety of medium depth spot peeling with 35% TCA in atrophic and rolled acne scars, in Asian skin (Fitzpatrick skin type III to IV). Patients and methods The study was carried out in the Department of Dermatology Sheikh Zayed Hospital form September 2009 to April 2010. Patients with rolled or atrophic acne scars who presented to skin or plastic surgery outdoor were enrolled in the study. After taking informed consent and counseling, the enrolled patients were put on prepeel regimen of topical application of 4% hydorquinone and tretinoin for 2 weeks. 1 to 3 spot peeling sessions, with 35% TCA, were carried out depending on severity of scars. Prepeel and postpeel photographs were taken. Results Nine patients with acne scars were enrolled in the study. The average age was 24 years. Total of 22 peeling sessions were done. Five patients had good, 4 had excellent and 1 patient had fair improvement. None of the patients had postinflammatory hyper- or hypopigmentation, scarring or keloid formation. Conclusion 35% TCA spot peeling in rolled and atrophic acne scars is safe, effective and affordable treatment in patients with Fitzpatrick skin type III to IV.


Single crystals of a highly conductive oxide SrMoO3 have been grown by a floating-zone method under argon atmosphere with ultralow oxygen partial pressure p(O2)∼10−25atm. The obtained single crystals of SrMoO3 reveal quite low resistivity at 300 K ρ(300K)=5.1μΩcm, which is the lowest to date in the values of ρ(300K) of all the oxides. Resistivity and specific heat data suggest that electrons in SrMoO3 behave as the Fermi liquid (correlated electron), and that its low resistivity is due to the extremely small electron-phonon interaction in SrMoO3.


A Norm Resistance Scale was constructed to measure four main aspects of deviance perception: the respondent's definition of the act as criminal or deviant; the intensity of the respondent's reaction; his preferences for official societal sanctions; and his general opinion concerning decriminalization. The scale was administered to urban and rural samples from five countries selected to represent a diverse array of political, social, economic, and cultural factors. Evidence was found for general agreement concerning the extent to which the control of a wide variety of deviant acts might be resisted. However, when cross-cultural comparisons were made for specific acts, wide differences were found both across countries and within countries, and the cross-country differences were the greater. Factor analysis was used to investigate similarity in underlying structure of deviance perception across countries. Although the data were not conclusive, they did suggest that two important factors-deviance protest and moral indignation-were operating on differing levels across all countries.


In present era demand for land is high for residential, commercial and industrial growth of any country and also we need to preserve land for agriculture. Due to this there is increase demand for high rise structures. These tall buildings are subjected to lateral forces due to wind and earthquake. Today's tall buildings have become more and more slender, leading to the possibility of more sway in comparison with earlier high rise buildings. To improve the dynamic response of these slender tall buildings different forms of structural system need to be adopted. One of the structural forms for RC buildings is by using shear walls. Lateral forces due to wind or earthquake are usually resisted by shear walls which are provided parallel to the direction of lateral load. These shear walls, by their shearing resistance and resistance to overturning, transfer the lateral loads to the foundation. In this study A 30 storey building with and without openings in shear wall is studied. Response spectrum method is used for dynamic analysis.


Australian & New Zealand Journal of Psychiatry, 47(10) This issue of the Journal has a thematic focus on the interplay between social factors and mental health. Despite the fact that surveys of mental health consumers consistently identify treatment and prevention as priorities, neither attracts the lion's share of resources, with prevention in particular retaining orphan status as a research topic. Jacka and colleagues (2013) argue that, in many other branches of medicine, preventive initiatives have delivered the greatest contribution to public health and treatment breakthroughs. They hypothesise that there is likely to be similar utility in the common mental disorders from embracing prevention strategies. They explore what is known about modifiable risk factors at a social, biological and environmental level and attempt to capitalise on the knowledge derived from the successes and failures of preventive efforts in other disorders, including obesity, cancer and cardiovascular disease. This is based on an expanding evidence base suggesting the importance of social and environmental factors, including stress, diet and lifestyle, to mental illness operative from early childhood (Pasco et al., 2011). They argue that there are common risk pathways, and hence significant synergies between preventive strategies for high-prevalence mental disorders and other non-communicable disorders. They additionally argue that most of the successes in the preventive sphere have been in the arena of public policy, and that partnering with agencies and disciplines with shared goals is likely to be a critical path to success. One of the unintended consequences of the policy of deinstitutionalisation and changes in attitudes to compulsory treatment (Callaghan and Ryan, 2012) has been a dramatic rise in the proportion of people in the forensic system with psychiatric problems and/or intellectual disability. Indeed, the forensic system has become, by default, the new asylums (Konrad, 2002). The needs of individuals with mental health problems and intellectual disability in the forensic system are therefore an increasingly pressing issue. Dias and colleagues (2013) explore the prevalence of mental co-morbidity amongst prisoners who have intellectual disability, arguing that the high rates of psychiatric burden and unmet treatment needs merit a coordinated approach to treatment delivery for this marginalised and disadvantaged cohort (Lawn, 2012). This need is borne out by an earlier study into high rates of psychotropic prescribing in this group (Griffiths et al., 2012). Concluding the forensic theme, Ducat and colleagues (2013) report that firesetters have high rates of psychiatric co-morbidity, particularly substance use, mood and personality disorders. Nevertheless, they emphasise that most firesetters have not had prior contact with mental health services nor received a psychiatric diagnosis. A means of identifying firesetters in advance would be of great benefit and, better still, would be the ability to administer effective treatment, perhaps even compulsorily. Anand and Pennington-Smith (2013) detail the complexities around the issue of compulsory treatment. They focus on the shifting landscape of societal attitudes to the balance of individual freedoms and personal and societal risks. They highlight the tensions and oscillations of the political pendulum between the personal and societal risks of not treating severe mental illness and the deprivation of personal liberty. Griffiths (2013) highlights the prevalence and disability of social anxiety and contrasts this with low levels of helpseeking behaviour. They highlight high levels of stigma and low levels of mental health literacy as drivers of low help-seeking. In an attempt to alleviate this, they have mapped a framework for help-seeking behaviour, in which a variety of modifiable factors have been identified. These include attitudes, beliefs, knowledge and the availability of help, as well as intervening with the behavioural elements secondary to the illness itself that impair motivation and the intention to seek help. Continuing the social theme, Coombs and colleagues (2013) review measures of social inclusion to complement the suite of outcome measures that are routinely used in public mental health services. They highlight the protective nature of social inclusion and the profound extent to which people with mental health difficulties feel excluded from the social mainstream, as evidenced in earlier work Contextualising the biology of psychiatry within its social environment


Background: Lower Gastrointestinal endoscopy is useful in the evaluation and treatment of many lower gastrointestinal diseases. There has been no report on indications and outcomes of diagnostic lower gastrointestinal endoscopy in the South Eastern part of Nigeria Aim: To determine the indications and findings in patients who had lower gastrointestinal endoscopydonein a private hospital in Enugu, south-eastern, Nigeria. Patients and Methods: A retrospective cohort study of patients who had lower gastrointestinal endoscopy between January 2012 and October 2015 at the study hospital was carried out. The medical records were reviewed to evaluate the indications and outcomes of the procedure. Results: A total of 151 patient records were reviewed. Males constituted 74.8% and females constituted 25.2% of the subjects giving a male: female ratio of 3:1. The ages ranged from 6-92 years with a median of 60 years. The commonest indication for the procedure was bleeding per rectum 81(53.6%) followed by constipation 15(10%) and unexplained anaemia 8 (5.3%). There was no request for routine screening colonoscopy. The most frequent findings were haemorrhoids 56 (37.1%), colorectal polyps 22 (14.6%), diverticulosis 15 (10%) and colorectal cancer 9(6%).Ulcerative colitis was seen in 1 patient (0.7%).However, 38(25.2%) of the patients hadnormal findings. Conclusion: The commonest indication for lower gastrointestinal endoscopy in the studied hospital was bleeding per rectum while the commonest finding was haemorrhoids. Routine screening colonoscopy was nonexistent in this population. Keywords: Lower gastrointestinal endoscopy, Indications, Findings


sudden onset, dyspnoea and dry cough of 4 days of evolution. The initial physical examination showed arterial hypotension (80/40 mm Hg), Since the 1980s there has been increasing interest in invasive infections due to Streptococcus pyogenes (the Lancefield Group A streptococci [GAS]). A number of reports have warned of a possible resurgence of severe clinical forms of GAS infections, which can range from uncomplicated superficial forms to severe invasive disease. Invasive GAS infection is associated with high mortality despite early antimicrobial therapy. We present 2 such cases, one involving pneumonia and the other bacteremia with no detected primary focus. Our aim is to draw attention to the continuing importance of GAS infections and the use of population-based surveillance to provide data for monitoring trends in incidence and identifying the relevance of particularly virulent strains. This provides a rational basis for disease control measures and future vaccine development. [Emergencias 2008;20:435-438]


The meaning of the notions «research activity», «activity» regarding the educational process in the secondary comprehensive school is defi ned. It is shown that the pupils research activity in the process of teaching Physics can be realized through such educational activities as: cognitive-productive activities, communicative activities, technical activities, psychological and educational activities, methodological and content activities. The basic stages of the pupils research activities are rationed. The results of the 11 th forms pupils some research works (projects) in Physics, namely: 1) determinating the krypton (Kr) spectrum lines emission wavelength using the diffraction grating; 2) investigating the phenomenon of polarization plane rotating in the magnetic fi eld, and 3) researching the phenomenon of polarization plane rotating in the optically active substances. Describes the technical characteristics for a universal platform through which these may conduct research (projects).


(1) Metivier, V. M. (Trinidad).-Intra-ocular foreign bodies in Trinidad and Tobago. Carribean Med. Ji., Vol. II, No. 3, 1940. (1) Metivier reviews his cases of intra-ocular foreign bodies between May, 1932 and May, 1940. In this period 32 patients out of a total of 14,940 new cases had intra-ocular foreign bodies. This incidence is rather higher than the 1 per 1,000 cases in records from Manchester, Wolverhampton and Moorfields. A Haab giant magnet was procured for the Colony in August, 1934. Before this seven cases had come in in 1932, and one case in 1933. Some of these had to travel to Europe for attention. Of the author's cases 30 were cases of magnetic foreign bodies. The visual results in 20 cases are given and they were good or very good in 50 per cent. of the patients. The r6le of occupation as the causation factor is shown; and the number of cases among persons emploved in local industry is relatively smaller than uwould be expected. "Apart from the manufacture of sugar and the production and refining of mineral oil and its by-products, major works of importance in the period under review were the construction of the new deep water harbour and the central water supply scheme." The cases from private and hospital practice are shown in tabular form as well as the visual results and a classification of all magnetic foreign bodies, in respect of occupational risk. R. R.J.


Background:  Gall bladder dyskinesia describes a clinical entity with symptoms of biliary colic but without objective evidence of gallstones. Recent work has suggested laparoscopic cholecystectomy as an effective treatment although this approach has not gained widespread acceptance in Australia.


The purpose of this article is to show the results of a qualitative research study carried out with school-age children of immigrants to France, who are going to be incorporated into the French school system (ENAF: eleves nouvellement arrives en France). The main goal of this study was to implement pedagogical activities based on the intercultural approach to achieve a more effective and smoother integration process for these immigrant children. With this purpose in mind, an action research study was undertaken to describe ENAF situation first, and then evaluate the research problem. After the implementation of the action plan and administration of the questionnaires, it was confirmed that the intercultural approach is a driving force that can help increase motivation and curiosity for the target language and culture.


. A conjecture of A. Joyal is proved, which states that, in contrast to topological spaces, toposes which are connected and locally connected are also path-connected. The reason for this phenomenon is the triviality of cardinality considerations in the topos-theoretic setting; any inhabited object pulls back to an enumerable object under some open surjective geometric morphism. This result points towards a homotopy theory for toposes.


A foreshortened log-periodic antenna which includes variously configured dipole elements and a tapered feedline is disclosed. The dipole elements are arranged in four regions. A first region, located nearest to a feed end of the antenna, includes solid triangular dipoles having constant base-to-height ratios. A second region, adjacent to the first region, includes solid triangular dipoles having decreasing base-to-height ratios. A third region, located adjacent to the second region, includes a single linear dipole. A fourth region, located adjacent to the third region and nearest to a low frequency end of the antenna, includes foreshortened dipoles. The feed line may be implemented either in coaxial or microstrip form so that a lower characteristic impedance is pressed at the feed end of the antenna than at the low frequency end of the antenna. Specifically, for a coaxial feedline having individual conductors separated by a distance "d' at the feed end of the antenna, the individual con ductors taper relative to each other so that they are separated by a distance of 2d-5d at the low frequency end of the antenna.


Electromigration-induced Plasticity and Texture in Cu Interconnects A. S. Budiman^ C.S. Hau-Riege^ P.R. Besser^, A. Marathe^ Y.-C. Joo^ N. Tamura\ J.R. Patel^^'\ W.D. Nix^ 'Dept. Of Materials Science & Engineering., Stanford University, Stanford, CA 94305 ^AdvancedMicro Devices, Inc., Sunnyvale, CA ^Dept Of Materials Science & Engineering, Seoul National University (SNU) ''AdvancedLight Source (ALS), Lawrence Berkeley National Laboratory (LBNL),Berkeley, CA 94720 Abstract. Plastic deformation has been observed in damascene Cu interconnect test structures during an in-situ electromigration experiment and before the onset of visible microstructural damage (ie. voiding) using a synchrotron technique of white beam X-ray microdiffraction. We show here that the extent of this electromigration-induced plasticity is dependent on the texture of the Cu grains in the line. In lines with strong textures, the extent of plastic deformation is found to be relatively large compared to our plasticity results in the previous study [1] using another set of Cu lines with weaker textures. This is consistent with our earlier observation that the occurrence of plastic deformation in a given grain can be strongly correlated with the availability of a direction of the crystal in the proximity of the direction of the electron flow in the line (within an angle of 10°). In out-of-plane oriented grains in a damascene interconnect scheme, the crystal plane facing the sidewall tends to be a {110} plane,[2-4] so as to minimize interfacial energy. Therefore, it is deterministic rather than probabilistic that the grains will have a direction nearly parallel to the direction of electron flow. Thus, strong textures lead to more plasticity, as we observe. INTRODUCTION Most interconnect metals are aggregates of crystalline grains. The crystalline lattice of each grain has a characteristic orientation, and a polycrystal is thus characterized by a distribution of orientations - its texture. Texture governs many of the physical, electrical and mechanical properties of polycrystalline materials. In metallic conductor hues in microelectronics integrated circuits, texture has been known to play important roles in the performance and reliability of the conductors, for instance in electromigration. [5] Recently, an unexpected mode of plastic deformation has been observed in Al[6,7] as well as in Cu[l,8,9] conductors - or intercormects, as they are usually referred to in industry - during electromigration (EM) stressing. This deformation occurs not in any random direction, but always in a direction transverse to the direction of electron flow in the lines. Texture and crystal plasticity have a close, intertwined relationship;Textures evolve during plastic deformation, while plastic deformation often depends on crystallographic orientations. Understanding crystal plasticity and how it progresses in intercormect lines during electromigration therefore might lead us to fundamental insights on the role of texture in electromigration.


In digital educational gaming, there are presently no games devoted to the trends of contemporary music. Also, there are no studies of noise-related sound in contemporary gaming discourse, yet noise is presently one of the most current trends in the arthouse world. The author of this study is carrying out a post-doctoral research into contemporary audio-visual art and digital game theory. Next to the other trends of modern gaming, the study incorporates analysis of noise-related artefacts that are of particular interest to the author taking into account her musicological education. The author intends to transfer knowledge gathered in the research process to the general public with an aim to facilitate the comprehension of noise music. Noise-related sound does not belong to the traditional system of musical expression thereof it requires an explanation and justification in order to be well apprehended. It has been explained in the literature of musicology, but serious gaming would help to disseminate these results and thus support intellectual education. The new experimental game Art Space explores the noise effect in order to deepen the understanding of this fuzzy area of contemporary culture. The game incorporates the historical background of noise music and its contemporary examples in the academic and alternative genres. The methods used in this study are literature analysis (theory of gaming and musicology), analyses of game sound scores and music examples. The mission of the research project and the innovative game Art Space is to pave the way to a new type of edugame that supports the documentation and analysis of aesthetical trends today.


Patency of ductus arteriosus (PDA) is morbid; especially it is a severe problem in preterm infants. Hence, to investigate the mechanism of DA closure is important for pediatrics. The present study focused on endothelial cells (ECs) in the DA because ECs lining vessels have a variety of functions and play a central role in homeostasis of the circulatory system. We hypothesized that ECs of the DA had unique characteristics from other vessels and that they should be the primary target to investigate the molecular mechanisms of the DA‐specific vasoconstriction and vascular remodeling.


Lithium–oxygen cells with nonaqueous electrolyte show high overpotentials during charge, indicating asymmetric charge/discharge reaction mechanisms. We present a kinetic modeling and simulation study of the lithium–oxygen cell cycling behavior. The model includes a multistep reaction mechanism of the cell reaction (2Li + O2 ⇄ Li2O2) forming lithium peroxide by precipitation, coupled to a 1D porous-electrode transport model. We apply the model to study the asymmetric discharge/charge characteristics and analyze the influence of a redox mediator dissolved homogeneously in the liquid electrolyte. Model predictions are compared to experimental galvanostatic cycling data of cells without and with 2,2,6,6-tetramethylpiperidinyloxyl (TEMPO) as redox mediator. The predicted discharge behavior shows good agreement with the experimental results. A spatiotemporal analysis of species concentrations reveals inhomogeneous distributions of dissolved oxygen and reaction products within the cathode during discharge. The e...


Two geographic races of the house musk shrew (Suncus murinus) were crossed and intercrossed in the laboratory. Many cases of male sterility were detected among the hybrids. Segregation analysis of the pedigree data showed that the inheritance of male sterility in interracial hybrids of S. murinus can be described within the framework of monogene polyallele model with sterility of a single allele combination. This model is similar if not identical to that proposed by Dobzhansky and Muller.


In this paper, the recently introduced control strategy referred to as model predictive pulse pattern control (MP3C) is adapted to the ACS 2000 five-level power converter of ABB. The drive consists of an induction machine and a five-level active neutral-point clamped (ANPC-5L) inverter. The power inverter is fed with optimized pulse patterns (OPPs) that produce minimum harmonic distortion in the stator winding of the ac machine. An optimal stator flux trajectory is calculated from these OPPs and a trajectory controller tracks it in real-time. In the proposed approach, trajectory tracking is based on model predictive control (MPC): a constrained optimal control problem is formulated and solved in real-time in a time-efficient manner. An event-based prediction horizon is employed in order to ensure fast tracking of the stator flux trajectory. The advantages of the proposed method are optimal steady-state behavior in terms of harmonic distortion and fast torque response. The method was tested on a pilot ACS 2000 power converter coupled to a general-purpose 1.21-MW induction machine. Experimental results were obtained from this industrial setup; they are presented in this paper to demonstrate the high performance of MP3C.


Objective: The study's objective is to evaluate the effectiveness of the Pap smear screening procedure for identifying precancerous lesions. Study Design: Prospective study Place and Duration: Department of Pathology, Nishtar Medical University Multan, From 1st October, 2021 to 31 March, 2022. Methods: There were 162 females had age 18-50 years were presented in this study. All of the women were given a complete physical examination, including a speculum exam and a vaginal exam, and their medical histories were recorded. Women's cervical cancer screenings often involved a Pap smear. Using an Ayre spatula, a smear was collected and spread over a labelled glass slide before being stored in 95% ethyl alcohol and delivered to the Pathology Department for cytopathological testing. SPSS 24.0 was used to analyze all data. Results: Among 162 females, 45 (27.8%) had age 18-30 years, 73 (45.1%) were aged between 31-40 years and 44 (27.2%) patients had 41-50 years. Mean BMI of the females was 22.4 ±6.52 kg/m2. Frequency of smokers was 4 (2.5%). Most common complaint was vaginal discharge, followed by irregular menstrual cycle and abdominal pain. We found that 63 (32.7%) cases had no pathology, frequency of inflammatory was 49 (30.2%) cases, atypical squamous cells of undetermined significance (ASUS) was 28 (17.3%), low-grade squamous intraepithelial lesions (LSILs) was 8 (4.9%) and high-grade squamous intraepithelial lesions (HSILs) was 5 (3.1%). As per HPV, low risk and high risk virus was found in 11 (6.8%) cases. Conclusion: The Pap smear is an easy, quick, and inexpensive way to check for cervical epithelial precancerous abnormalities. It has the potential to be employed as a routine screening tool, leading to better treatment outcomes and lower death rates. Increased detection of these lesions is facilitated by the Pap test and the HPV-PCR test. Keywords: Cervical Cancer, Pap smear Test, HPV, Pathology


Inverter with output LCL filter is widely used in power system. It has better switching frequency harmonic suppression effect, meanwhile it has resonance problem. Virtual resistor damping can suppress the resonance, but it affects the current control character, particularly for harmonic current. This paper develops the detailed models of the inverter with virtual resistor damping for output harmonic current control. Based on the analysis of current control loop with virtual resistor, the transfer function of current loop is obtained. Moreover, with the optimal value of virtual resistor, the performance of inverter is similar to 2nd order low pass filter. To control the output current equals to reference current, reference regulation method is proposed. At last, simulation and experimental results verify the correctness of theatrical analysis and effectiveness of the method.


This paper focuses on drought risk assessment using satellite data. Methods of the extreme value theory (EVT) are applied for a time series of vegetation health index (VHI) derived from the National Oceanic and Atmospheric Administration satellites in order to provide drought hazard mapping. A Poisson-GP (generalized Pareto) model is applied for modelling VHI extreme values. The model allows estimation and mapping of return periods of different categories of droughts. An approach to economical risk assessment due to droughts is presented that relies on the following components: damage function assessment, crop yield assessment, and crop area estimation. The advantage of the proposed approach is that it allows quantification of drought hazard through the drought return period, damages, and ultimately drought risk using satellite data. The derived drought hazard map is integrated with high-resolution crop map to provide final estimates of risk. The proposed approach is implemented for quantitative assessment of drought risk for the Kyiv region in Ukraine. The derived map shows that risk is distributed non-uniformly over the region, thus allowing identification of areas with higher risk. Such a map would be of great benefit to both local authorities to take directed actions to reduce the risk and insurance companies operating in agriculture sector.


These are notes for a lecture given at CIRM in 2014, for the Journées Nationales du Calcul Formel . We explain the basic algorithms based on combining congruences for solving the integer factorization and the discrete logarithm problems. We highlight two particular situations where the interaction with symbolic computation is visible: the use of Gröbner basis in Joux's algorithm for discrete logarithm in nite eld of small characteristic, and the exact sparse linear algebra tools that occur in the Number Field Sieve algorithm for discrete logarithm in large characteristic. Disclaimer: These notes contain no new material. They also do not aim to be a survey, and exhaustivity is not a goal. As a consequence, many important works (old or recent) are not mentioned. 1 The problems and their cryptographic signi cance 1.1 Cryptographic context Cryptography, as a science that studies tools to secure communications in a wide sense, contains various sub-themes among which the so-called public-key cryptography covers algorithms such as digital signatures, and asymmetric encryption, i.e. encryption systems in which the key that is used to encrypt is publicly known, while the corresponding decryption key is known only by the recipient. This is useful in particular when the participants do not share a common secret prior to any interaction. Most public key algorithms used today are based on di cult problems in number theory, and more precisely integer factorization and discrete logarithm problems, which constitute the central topic of this lecture. Let us give two examples. EMV. The EMV is the standard adopted by Visa, Mastercard, the French Carte Bleue and many others, to secure the chip-and-pin smartcard transactions. The public key part of the standard is based on the RSA cryptosystem, whose security relies on the presumed di culty of factoring integers. The typical key sizes found in today's cards are 1024 bits or slightly more. Anyone who would be able to factor numbers of this size could easily break into the system and create fake transactions. SSL/TLS. The SSL/TLS standard is the one used to secure many protocols found on the internet. For instance, the s at the end of https acronym means that the connection between your webbrowser and the server is secured using SSL/TLS. By clicking on the lock picture when browsing


The inspection of laser treated stainless steel alloy is performed via a microcomputer on-line to a digitizer which records interferograms produced using projection interference techniques. Heating was performed by an high power industrial carbon dioxide laser. Special image processing algorithms were developed to extract the heat variation features from the surrounding background. The results reveal the quality of the laser heat treatment and its effect on different areas of the alloy. Lateral and depth resolutions of the order several microns were achieved. A topological mapping of the treated material is presented as the three dimensional color (or shades of gray) contour of the surface.


We present a planning algorithm for a mobile robot in unknown indoor dynamic environments. The algorithm takes into account the robot's own dynamics and the dynamic obstacles' future behavior in a safety hierarchy. It also uses an appropriate time horizon for planning and respects the timing constraints on various modules of the planner that are imposed by interleaving of planning and execution. We provide a formulation of this safety hierarchy in a single step via a composite costmap. The planning algorithm has been implemented in Player/Stage. We have run extensive simulations and compared the performance of the full safety hierarchy with various permutations of safety levels, as well as with some baseline algorithms over three different performance measures. We show that our safety hierarchy performs statistically significantly better across most performance measures and most simulation scenarios.


Strange nonchaotic attractors (SNAs), which are realized in many quasiperiodically driven nonlinear systems, are strange (geometrically fractal) but nonchaotic (the largest nontrivial Lyapunov exponent is negative). Two such identical independent systems can be synchronized by in-phase driving: Because of the negative Lyapunov exponent, the systems converge to a common dynamics, which, because of the strangeness of the underlying attractor, is aperiodic. This feature, which is robust to external noise, can be used for applications such as secure communication. A possible implementation is discussed and its performance is evaluated. The use of SNAs rather than chaotic attractors can offer some advantages in experiments involving synchronization with aperiodic dynamics.


A new method for phase-only optimization of array antennas with constrained amplitude is presented. In order to form a given antenna pattern for array antennas, variable metric algorithms, Davidon-Fletcher-Powell(DFP) and Broyden-Fletcher-Goldfarb-Shanno (BFGS) were joint used to optimize the phase distribution of excita-tions, thus, the optimized main lobe of the antenna pattern is fitted for the given one and the side lobe level is efficiently controlled. Since N-dimensional unrestricted function is sloved, the method shows fast convergence and small amount of computing,so it is a valuable beam shaping method for array antennas.


This paper presents the speed monitoring of a DC motor drive using field programmable gate array which provides a faster operation than any other conventional analog methods or digital methods like DSP. The paper consists of two parts. The first part deals with the MATLAB simulation for speed control of a DC motor using fuzzy logic. The most effective method of control is the control of PWM, generated for triggering the converter circuit. The PWM is given through the driver circuit to the half bridge converter, which controls the speed of the motor. The hardware part deals with the speed monitoring of the DC motor using FPGA. In this implementation, the PWM is generated using XBLINX software, which is given to the converter through the FPGA The use of FPGA reduces the processing speed and hence increases the efficiency of the motor. The result of the open loop control is compared with the fuzzy logic control.


The time course of the center of pressure (CoP) during human quiet standing, corresponding to body sway, is a stochastic process, influenced by a variety of features of the underlying neuro‐musculo‐skeletal system, such as postural stability and flexibility. Due to complexity of the process, sway patterns have been characterized in an empirical way by a number of indices, such as sway size and mean sway velocity. Here, we describe a statistical approach with the aim of estimating "universal" indices, namely parameters that are independent of individual body characteristics and thus are not "hidden" by the presence of individual, daily, and circadian variations of sway; in this manner it is possible to characterize the common aspects of sway dynamics across healthy young adults, in the assumption that they might reflect underlying neural control during quiet standing. Such universal indices are identified by analyzing intra and inter‐subject variability of various indices, after sorting out individual‐specific indices that contribute to individual discriminations. It is shown that the universal indices characterize mainly slow components of sway, such as scaling exponents of power‐law behavior at a low‐frequency regime. On the other hand, most of the individual‐specific indices contributing to the individual discriminations exhibit significant correlation with body parameters, and they can be associated with fast oscillatory components of sway. These results are consistent with a mechanistic hypothesis claiming that the slow and the fast components of sway are associated, respectively, with neural control and biomechanics, supporting our assumption that the universal characteristics of postural sway might represent neural control strategies during quiet standing.


Students are the major clients of many institutions, and they've come to realize that they're in the service industry. Before designing a performance-enhancement program, a student's existing status must be evaluated. Higher education officials place a strong focus on accurately predicting a student's performance. This study tries to reveal the many factors that influence a student's choice to join a certain college or institution. Students who are able to forecast their own performance early on are better able to take action to enhance their results. In order to achieve a high level of education, several forecasts of student performance have been devised. However, these predictions have been shown to be inadequate. EDM uses a variety of elements, including social, behavioral, cognitive, and motivational, to predict student behavior. Many domain models have previously been improved by using optimal learning and instructional sequences. This article examines a variety of educational data mining strategies in great detail. Data mining in education also faces a number of concerns and obstacles, which are explored in this article.


MESSAGE FROM THE PRESIDENT AND CEO Getting to the Right Tables of Influence Partnership was a driving force at AACP during the past year. We sought "all the right tables of influence," pursuing other organizations in education and healthcare that are contributing to the dramatic changes underway in our society. We are pleased to provide a recap of this work in the context of AACP's 2012-13 broad accomplishments. Chief among the important tables of influence at which AACP had a seat in 2012 was the unique summit hosted by the Accreditation Council for Pharmacy Education. AACP leaders and others from the Academy worked with ACPE to critically examine forces of change in healthcare that should impact the next version of ACPE standards and guidelines for Pharm.D. program accreditation. These guidelines will affect pharmacy education and the Academy's contributions to society for many years to come. The Institute of Medicine was another influential table to which AACP was drawn. In partnership with the American College of Clinical Pharmacy and Research Corporation Technologies, AACP initiated the first IOM anniversary fellowship in pharmacy. Dr. Sam Johnson, clinical pharmacy specialist at Kaiser Rocky Mountain and clinical instructor at the University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, is now serving in the first of this two-year fellowship. He will be interacting with IOM members during study committees, forums and board meetings. Our work to advance interprofessional education ensures that pharmacists are integrated as essential team players in healthcare delivery redesign. AACP--along with its five partner organizations in the Interprofessional Education Collaborative, representing medicine, nursing, dentistry and public health education--convened two IPE institutes this past year. We've planned three more to meet the strong demand for faculty development to accelerate interprofessional learning at our member institutions. Again, the IOM was an important platform for examining IPE. As a founding member of the IOM Global Forum on Innovation in Health Professions Education, AACP co-chaired the planning committee for the first two forum workshops, which explored ways to advance IPE across all the health professions and in a global context. AACP's interaction with thought leaders continued throughout the year. Cooperative efforts--such as those with the IOM and ACPE along with many others--strengthened our member service to pharmacy schools and educators in multiple meaningful ways. This annual report offers a summary and shines a light on our efforts to discover, learn and care in order to improve health. J. Lyle Bootman, PhD President Lucinda L. Maine, PhD, RPh Executive Vice President and CEO CRITICAL ISSUE #1 Human Resources for Education, Research and Service How does AACP assist members in attracting, motivating, developing and retaining the highest quality and most diverse faculty, students, administrators and professional staff? Academic Leadership Fellows Program A strong pharmacy Academy requires continuous robust leadership. AACP plays a vital role by helping gifted faculty prepare for roles as future academic leaders. Through Academic Leadership Fellows Program, pharmacy school deans nominate faculty, mentor fellows during their ALFP year and facilitate development sessions. ALFP is now enrolling its 10th cohort. This brings the total number of participants to nearly 300 since the program began. An advisory committee is being convened to reflect on the first decade of ALFP. The committee will put forth recommendations to ensure that participants continue to flourish through this superlative professional development opportunity. Interprofessional Education and Faculty Development The Interprofessional Education Collaborative (IPEC) hosted an encore faculty-development institute, Building Your Foundation for Interprofessional Education, in October 2012. …


Technology start-ups able to globalize from inception in the literature are called "born global" (BG) companies. The paper aims to study the internationalization trajectories of BGs in the developing entrepreneurial ecosystem framework of the emerging knowledge economy. We suppose that value system and networks of BGs are the part of general entrepreneurial ecosystem and the factors leading to early internationalization are new market conditions, technological advantages and entrepreneurial learning. The three case studies demonstrate the different globalization trajectories of start-ups depending on the maturity of the entrepreneurial ecosystem. For the conclusion has been proposed that shortening of start-up period, growing number of success stories and growing intensity of start-up creation indicate the maturity of the entrepreneurial ecosystem.


RACK1 is a scaffold protein that orchestrates numerous protein‐protein interactions and cellular signaling mechanisms. The C. elegans genome encodes a single RACK1 homolog that is >70% identical to mammalian RACK1. GFP reporters demonstrated that RACK1 is expressed in numerous worm tissues including the gonad, spermatheca, intestine and excretory cell. Systemic knockdown of RACK1 expression by RNAi feeding caused complete sterility. We carried out video microscopy in living worms to identify the cellular basis of the fertility defect. Oocytes form in the proximal gonad, a tube‐like structure that is comprised of contractile myoepithelial sheath cells and attached to the spermatheca. A signal from sperm stored in the spermatheca induces meiotic maturation in the most proximal oocyte. Secretion of an EGF‐like protein from the maturing oocyte triggers sheath cell contraction, dilation of the gonad‐spermatheca valve and ovulation. Gonads of RACK1 RNAi worms contained endomitotic oocytes, suggesting the presence of an ovulation defect. Video analysis indicated that sheath cell contraction was largely normal. However, dilation of the spermatheca valve failed to occur or occurred inappropriately after ovulation was complete, causing oocytes to reenter the gonad. Spermatheca valve function is controlled by PLC‐ε and PLC‐γ/IP3–dependent Ca2+ signaling processes. Our results suggest that RACK1 plays an essential role in PLC and/or IP3 signaling pathways. The readily observable fertility and spermatheca defects caused by RACK1 loss of function provide the basis for ongoing genetic analysis of RACK1 signaling mechanisms.


The utility model relates to a nonpolarized communication circuit based on ammeter application. The nonpolarized communication circuit mainly solves problems of polarity automatic determination of a 485 communication bus under various conditions in ammeter application and problems of drive capability of an ammeter without an up-and-down resistor. The nonpolarized communication circuit comprises a 485 communication bus (A/B bus) judgment module to obtain polarity determination signals and control a switch which receives output and transmits input, so as to achieve an objective of polarity automatic determination of the 485 communication bus under various conditions in the ammeter application. Then, drive capability enhancing modules are started based on results of the polarity automatic determination and original data transmission on the 485 communication bus, so that the problems of insufficient drive capability when no up-and-down resistor exist in ammeter nonpolarized 485 communication system application. Finally, a whole polarity automatic determination module is turned off so as to ensure low power consumption and anti-interference capability of the whole circuit.


Long-term memory or long-term dependencies of financial time series' returns allows testing the efficiency of capital markets. This paper investigates the long-term memory in Sibex market by both static and dynamic approaches. Identifying the long-term memory in futures market can be useful for detecting arbitrage opportunities in this market and thus for managing portfolios of financial assets. For measuring the long-term dependencies we used the Generalized Hurst Exponent because it has the smallest estimation error compared to other methods. The implementation of GHE test on rolling windows allows for robust results concerning the degree of markets' informational efficiency in time.


To meet the growing demand for data consumption, IO speeds, IO ports, CPU core count and pin density continue to increase every generation. In the last few generations, the number of ports of peripheral component interconnect express (PCIe) and double data rate (DDR) interfaces have nearly doubled in CPUs. Ball grid array (BGA) breakout in current CPUs is becoming a challenge due to the increased density. Significant noise can get coupled to high-speed signals if the package or BGA breakout is less than optimal. In this paper, various BGA breakout schemes that are popularly used are discussed. The advantages and limitations of these schemes are discussed with frequency domain data. In addition, the paper also highlights that trace-to-via fringe coupling at high frequencies can impact high-speed signals adversely


The management of dairy production systems based on rotational grazing and maize-concentrate feeding requires a complex lookahead decision making procedure to elaborate a seasonal strategy that is sufficiently robust to uncertainty. In this paper, the problem is characterized rather precisely as finding for the late winter to early summer period an appropriate combination of commitments concerning the fields allocated to grazing, those kept just in case of need, the time profile of maizeconcentrate distribution, the nitrogen fertilization policy and the field rotation policy. A simulation tool designed to evaluate tentative man-made strategies under given climate scenarios is described.


CANZIAN, R., Le Chatelier's Principle Analysis in chemical textbooks. 2011. 80 f. Dissertacao (Mestrado). Instituto de Quimica, Instituto de Fisica, Instituto de Biociencias e Faculdade de Educacao, Universidade de Sao Paulo, Sao Paulo, 2011. This work presents a reflection on the role of the Le Chatelier"s principle concerned by its creation and some implications in the teaching of chemistry. The main purpose was to analyze as high school chemical textbooks approach with this subject. For this, historical aspects of the evolution of the principle were studied with the objective of discussing important characteristics, for example: the universal character of the principle, his problems and limitations regarding their applications to previse changes in chemical equilibrium systems and the possible alternatives to the use of the principle. It was found that the principle formulations were similar to that more simple and popular wrote by Le Chatelier, in the year of 1888. It was also made an analysis of how the textbooks address the issue of variables that influence in the state of equilibrium such as: concentration, pressure, catalyst and temperature. Also was analyzed the i llustrations present in these books with the objective of address the equilibrium change based in the of Johnstone"s triangle (that explicitly shows the macroscopic, microscopic and representational levels of chemical knowledge). The main results showed that the majority of the figures in textbooks refers only to macroscopic level and the effects done by of the equilibrium reactants concentration change. There are few figures which are related the three levels represented in the Johnstone"s triangle. Is very important that teachers include the illustrations missing, mainly the microscopic level, once that this level is essential to correct understand of chemical equilibrium change in the molecular level. In general, the authors of chemical textbooks present the Le Chatelier"s principle in an inductive manner, vague and ambiguous. They never present theoretical aspects and limitations in the application of the principle. This stresses the infallible character of Le Chatelier"s principle and transmits the idea that it is an absolute truth. This superficial treatment of the principle can encourage processes of teaching-learning based on memorization and the students can correctly use the principle in the problems solutions without have an exact understanding the phenomena.


Introduction: The detection of biosignatures in mineral matrices in extraterrestrial planetary environments relies on the successful encapsulation and preservation of organic material or other biotic signals. Serpentine-bearing units have been detected on Mars [1] and considered important to astrobiological study there [2,3]. Serpentinites have diverse petrogenetic sequences, often involving complex fracture and veinfilling histories. The accumulated load of late stage vein minerals holds promise as a stockpile of biological debris, perhaps concentrated over time. In this work, we interpret co-registered μFTIR and Raman spectroscopy data for natural serpentinites sampled near the wells of the Coast Range Ophiolite Microbial Observatory [4].


Reigstad B. Henvisninger til psykisk helsevern for barn og ungdom i Norge. En sammenligning av tre barne- og ungdomspsykiatriske poliklinikker over en elleve-ars periode.Referrals of 3939 children and youths, 0-18 years of age, to three outpatient clinics sited in different parts of Norway, are analyzed for the period 1975-85 on basis of annual reports from the three clinics. Referrals are analyzed in relation to age, sex. referral agency, and problem. Health agencies were found to be the most common source of referral in all three clinics, 50% in two of them, followed by school agencies. Referrals from child protective agencies are increasing. Rate of family and self referrals seems to depend on accessibility of the clinics in terms of geographical distances. Boys are more frequent referred until the age of 14 years after which the rate is decreasing. Girls are more frequently referred from this age on, and the difference between boys and girls in terms of total sex ratio seems to diminish. The same tend...


Membrane-based gas separation is a process necessary for the realization of a clean energy world. Membranes comprise of nano-sized pores through which gas mixtures are separated due to the significantly different transport rates of each gas. For each application there is a desired flow rate (permeability) and purity of by-product (selectivity). By tuning pore size and operating temperature the desired outcome can be achieved. Here the mathematical equations that govern gas transport throughout the pores are combined and analysed to provide overall guidelines for tailoring pore size and operating temperature.


In some signal collection system,the work voltage changes with the environment.At that time,a high speed and precision feedback system is very important.A biology signal sensor control system compacted by TMS320VC5416 and MAX5633 is presented in this article.Application of a high precision and multicenter D/A signal collection system is discussed.The hardware and software are also given.This system solves the problem brought by the change of the sensor′s work voltage,and is voluable to guiding the signal collection system design.


The invention discloses an aqueous adhesive for a lithium ion secondary battery. The aqueous adhesive contains a soft monomer, a hard monomer, a functional monomer, an emulsifying agent, an initiating agent, a buffering agent and deionized water, wherein the functional monomer contains at least two different functional groups. The aqueous adhesive has the strong adhesive property for a solid powder material used for the lithium ion secondary battery, and simultaneously has the excellent corrosion resistance to an electrolyte.


To describe the clinicopathological characteristics and prognosis of subsequent non‐muscle‐invasive bladder cancer (NMIBC) after radical nephroureterectomy (RNU) for upper urinary tract urothelial carcinoma (UTUC), and particularly its response to intravesical Bacillus Calmette‐Guérin (BCG).


The cover material (1) is bonded to the main face (3) of the wooden panel (2) so that at least two parts of the material protrude beyond the main face on at least two adjacent side edges (6) of the panel. The protruding cover material is then bent and pressed against these adjacent side edges.


The cascaded integrator comb filter is commonly used as a first stage decimation filter in communications systems. This paper reviews sharpening techniques for correcting the passband 'droop' present in the frequency response of these filters. A variation on an existing technique that would allow a partially non-recursive (and, therefore, potentially higher speed) implementation is presented for CIC filters with power of two decimation ratios.


A differently expressed gene wound inducible transcript 3.0 (wit3.0) was isolated from rat wounded gingival fibroblasts. Due to the unique expression pattern of this gene, we hypothesize wit3.0 expression accelerates wound contraction. The objective of this study is to investigate the potential role of wit3.0 in wound contraction. We compared the contractility of wounded/ un‐wounded gingival and skin fibroblasts by in vitro collagen gel contraction assay. wit3.0 siRNA were transfected to wounded fibroblasts to further test the function of wit3.0. In vivo function of wit3.0 was tested by transducing lentiviral vector carrying wit3.0 mixing with gelatin to wounded skin. Wound area sizes were measured, and wit3.0 gene expression and protein levels were determined. Results showed wounded gingival fibroblasts had the fastest contraction rate. This contractility was inhibited by the siRNA treatment. Transduction of wit3.0 to skin tissue also showed a faster wound closure rate. We conclude wit3.0 expression positively correlates to the cell's contractility thus warrant further investigations of the mechanism of this gene and its potential application to skin wound healing. Source: various donors.


This thesis presents the design of a dynamically configurable Fast Fourier Transform (FFT) processor built around a continuous flow, mixed-radix architecture. Complex FFTs/inverse FFTs (IFFTs) of size 16to 4096-point can be performed, with the option to turn on/off block floating point (BFP), and to divide the input data by 2 (to prevent overflow in the butterfly). An addressing scheme is presented to accomodate performing FFTs of any size. Minimizing twiddle factor data storage is discussed with a method to improve FFT accuracy and reduce the number of multiplications performed within an FFT. The datapath for this processor varies between 16to 34-bits. Built in a 65 nm technology, a 1024-point FFT is performed in 1.29 μs and a 4096-point FFT is performed in 6.11 μs at a clock speed of 1.01 GHz. The accuracy is 80 dB for a 64-point FFT and 73 dB for a 1024-point random-data FFT. The processor consumes 250 mW at 1.3 V, and takes up an area of 1.01 mm.


The book of Genesis contains two creation myths which have corollaries in the Igbo creation myth, as in other ethnic groups in Africa. This is particularly in the area of sanctity of life. The first Genesis creation mythexplicitly states that man was created in the image (Hebrew צלם ) of God, and after His likeness, (Genesis 1: 26-27). The second creation myth states that God formed man out of the dust of the ground and breathed into him the breath of life (that is, a part of Himself) and man became a living being (Genesis 2:7). In Igbo creation myth, the God, Chineke, created man with part of Himself. Here, the God, Igwe, and the Goddess, Ala, (both components of the creator God, Chineke) met and formed human beings, male and female. The significant points of convergence between the Genesis creation myths and the Igbo creation myth are first, that man was formed by the direct action of God (gods) and second, that man contains a component of God (gods). Mankind is not just a physical being that accidentally came into existence. Mankind was formed by God (gods) carrying a part of Himself (themselves). For this reason, life is highly revered in Igboland, as in all parts of Africa. This paper, therefore, examined human life and its sanctity as derivable from creation myths in Genesis and some Igho communities. The comparison is vital for the appreciation of life and its enhancement in Afro-Christian social milieu.


Abstract Background The pathway consisting of the receptor programmed cell death 1 (PD-1) and its ligands plays a crucial role to escape T cell-mediated immunity. Antibodies targeting PD-1 and its ligands have beneficial antitumor effects on many cancers, and some cases show long-time survival. Methods We retrospectively reviewed medical records of non-small cell lung cancer (NSCLC), head and neck cancer, and renal cancer patients who received subsequent therapy (chemotherapy or targeted therapy) after the administration of anti PD-1 or PD-L1 antibody between January 2016 and December 2018 at Okazaki City Hospital. Subsequent therapy included S-1, Pemetrexed (PEM), Cisplatin (CDDP) +PEM +Bevacizumab (BV) and PEM +BV maintenance, Carboplatin (CBDCA) +PEM and PEM maintenance, weekly Paclitaxel (wPTX), Docetaxel (DTX), Everolimus and Pazopanib. The latest analysis was performed in June 2019. Results Of the 13 patients who had received anti PD-1 antibody (NSCLC/head and neck cancer/renal cancer, 7/3/3; Nivolumab/Pembrolizumab, 10/3), 2 had partial response and 7 had stable disease for the 1st line subsequent therapy (overall response rate, 15%; disease control rate, 69%). Duration of median progression free survival (PFS) at the therapy was 10.9 m (S-1 in NSCLC), 16.0 m (CDDP+PEM+BV and PEM+BV maintenance), NE (PEM), 6.2 m (CBDCA+ PEM and PEM maintenance), 5.0 m (wPTX), 0.5 m (DTX), 6.0 m (Everolimus) and 14.1 m (Pazopanib) each. Median overall survival was 14.0 m, and 7 of the 13 patients were still alive. Two patients with Grade 2 interstitial lung disease due to Everolimus and PEM were successfully treated. Conclusion PFS of S-1 in NSCLC after the administration of anti PD-1 antibody was longer than that of the East Asia S-1 Trial in Lung Cancer. Interstitial lung disease due to targeted therapy was successfully managed.


Components of genetic variation for pod yield and other associated yield characters in lablab bean have been estimated through six-parent diallel cross in F2 generation. Additive as well as dominance components were significant for all the characters in both environments. Diallel analysis after Hayman's approach suggested environmental interaction for flowering date, pods/inflorescence, inflorescence/plant and pod yield/plant. Complete dominance was observed for flowering date in environment 2, flowers/inflorescence and pod yield/plant in environment 1 and pods/inflorescence, pod width in both environments. Over dominance was displayed for flowering date in environment 1 and for pod yield/plant in environment 2. Partial dominance was found for flowers/inflorescence in environment 2 only but for inflorescence/plant, pod length and 10-pod weight in both environments. Introduction Lablab bean is a protein rich major winter. vegetable in different parts of Asia. Many types and varieties of lablab bean are found in Asia. Little research work has been done to improve its pod yield and other associated characters. Work on genetic improvement of this crop is mainly done in India (Baldev et al., 1988), but not much studies on genetic architecture. The improvement of yield depends on a better understanding of the type of gene action. Evaluation of genotype performance in different environments is important in plant breeding. Genetic studies on lablab bean have been reported by some investigators (Mia et al., 1989; Ushakumari and Chandrasekharan, 1992; Newaz et al., 1995; Arora and Loodhi, 1998). The differential response of genotypes when subjected to different environments possess a major problem relating phenotypic performance to genetic constitution and make it difficult to decide which genotype should be selected. It is important to understand more fully the nature of genotype x environment (GXE) interaction to make testing and selection of genotypes more efficient. The present investigation about the nature arid magnitude of the components of variation yield and its direct components would be helpful in deciding the most efficient breeding procedure in Lablab purpureus. Materials and Methods Six genotypes of lablab bean were crossed in all possible combinations excluding reciprocals in Bangladesh Agricultural University Farm at Mymensingh. Seeds of parents and 15 F, families were shown with five replications in RCB design. Two cultural environments lenv.1 was with fertilizer and early sowing and env. 2 was without added fertilizer but had relatively latter sowing date were considered to investigate environmental interaction in the study. Sowing distance was 2 m x 2 m, between and within the rows. Diallel analysis was done following Hayman (1954 a,b) approach. The genetic components of variation in F2 population were calculated according to Jinks (1956) and heritability was estimated as outlined by Verhalen and Murray (1969) for population. Results and Discussion From the Hayman analysis of variance (Table 1) environmental heterogeneity was found for additive (a) genetic effect in inflorescence/plant and pod yield/plant for dominant (b) genetic effect in pods/dnflorescence and for both in flowering date. In both the environments, additive and dominant genetic eornpononts were important in the regulation of almost all the characters except inflorescence/plant and 10-pod weight in environment 2 which showed good agreement with Table 2. Although additive genetic components preponderance in inflorescence/plant, pod length and pod yield/plant, environmental interaction was observed only pod yield/pant for additive component. Environment could not influence upon Flowers/inflorescence, pod length, pod width and 10pod wt. Table 2 suggested that in majority of the characters, excess dominant allele was present in their parents except inflorescence/plant, pod length and pod yield/plant because their F value was positively significant. For all the characters differences between parents and crosses were present, which is measured by h value. Degree of dominance was measured by (H1/D)/4) parameter. Complete dominance was observed in pods/inflorescence


I submitted a Brief Communication to Nature on 15th June 2009, pointing out that its issue of 30 April 2009, with no fewer than nine articles claiming that it is not the atmospheric concentration of carbon dioxide (i.e. [CO2]) that is responsible for rising global mean temperature (GMT), as asserted by the IPCC, but the total cumulative volume of anthropogenic emissions of CO2. I pointed out that this approach implied there are and have been no net uptakes of CO2 by the global biospheres, both oceanic and terrestrial. My rejection note from Nature's Michael White stated the articles had "implicitly" taken such net absorptions into account. In a second Brief Communication I responded as follows showing this not to be the case, but with the same result, rejection by Dr White (8th July 2009).


In response to Martha Joynt Kumar's essay on maximizing presidential transitions while minimizing hazards, this essay presents additional practical recommendations, framed within the context of the upcoming presidential transition.


This thesis focuses on epigenetic processes involved in the regulation of gene expression in endogenous pararetroviruses (EPRVs), exemplified by endogenous Petunia vein clearing virus (ePVCV-1) and its episomal form, PVCV. Since ePVCV-1/PVCV was found to have features characteristic of retrotransposon and endogenous retroviruses (Richert-Poggeler and Shepherd, 1997), detailed analysis of these retroelements in different systems gives a deep insight to understand the interconnection of these elements and their regulation by the host cellular machinery as described in chapter one.
Chapter two describes the different silencing states of ePVCV-1 in two distinct Petunia hybrida lines, "white 138" (W138) and "rose du ciel" (Rdc). Despite of ePVCV-1 integration into the pericentromeric regions of the Petunia hybrida chromatin, we found that this position still allows for a low level of transcription that increases with increasing plant age and is higher in W138 than Rdc. To correlate these findings with epigenetic marks, we compared these cultivars in respect to DNA- and histone-methylation and siRNA production. Using bisulfite treatment, ePVCV-1 sequences were found to be methylated at cytosines in all contexts. Astonishingly, however, in both hosts the methylation rate in the non-coding region containing the promoter is relatively low. This might indicate a special ability of the viral promoter to escape complete inactivation by methylation. In Rdc, nearly all histones covering the ePVCV-1 coding region were methylated at lysine 9 of histone 3 (H3K9), a flag for heterochromatin, while in W138 about half of them were of the H3K9- and half of the H3K4-type, the latter representing active chromatin. Interestingly and in accordance with the DNA methylation data, the H3K4/H3K9 ratio was relatively high for the promoter region of both cultivars. The higher H3K4/H3K9 ratio in W138 correlates with an increased rate of ePVCV-1 induction. Furthermore, we show the production of siRNAs of three different size classes (24, 22 and 21 nt) in both cultivars, all of

which are weaker in W138 than in Rdc. Together our observations indicate that W138 is less efficient in silencing of the endogenous viral sequences than Rdc.
In chapter three, I investigated the promoter region of PVCV and determined its ability to direct transcription in transgenic plants. Furthermore, I analyzed the regulatory elements of this particular promoter in comparison with those of other plant pararetrovirus promoters. In particular I studied the functionality of an as-1 like element and its contribution to PVCV promoter expression. Although originally of medium strength, the promoter could be improved to about 50% strength of that of the CaMV 35S promoter by "repairing" a pair of degenerated as-1 enhancer elements. We show, that the promoter includes upstream and downstream enhancer elements, and that it can be improved considerably by restoring two degenerated as-1 elements.
The concept of creating virus-resistant plants by transformation with genes derived from the pathogen genome is a well-exploited and highly effective procedure to fight viruses as causal agents of diseases in plants (Fichen and Beachy, 1993). Recently it has been demonstrated that RNA interference (RNAi) can be successfully triggered against plant viruses by transient expression of an inverted repeat of target sequences (Pooggin et al., 2003; Tenllado et al., 2004). In chapter four, we use this technique to develop RNA-mediated banana streak virus resistance via TGS and/or PTGS and the method should prevent the outbreak of virus infection upon rare spontaneous induction of endogenous BSV in tissue culture.
Chapter five is a publication in EMBO journal to which I contributed in major ways. This paper describes the production of cloned PVCV originating directly from Petunia plants and from a Petunia gene library. Our findings allowed comparative and direct analysis of horizontally and vertically transmitted virus forms and demonstrated their infectivity using biolistic transformation of a provirus-free petunia species. Some integrants within the genome of P.hybrida were found to be arranged in tandem, allowing direct release of virus by transcription. In addition to known inducers of endogenous pararetroviruses, such as genome hybridization, tissue culture and abiotic stresses, we observed

activation of PVCV after wounding. Our data also support the hypothesis that the host plant uses DNA methylation to control the endogenous pararetrovirus.
In a preamble I point out, which part of this paper is based on my own experimentation and interpretation. on to control the endogenous pararetrovirus.
In a preamble I point out, which part of this paper is based on my own experimentation and interpretation.


The stabilities log(K/dm3 mol–1) of [ML1]+ formed by 1,4,7,10-tetrakis(2-hydroxyethyl)-1,4,7,10-tetraazacyclododecane (L1) were found to vary with M+ in the sequence Li+(8.07 ± 0.05 and 8.90 ± 0.05), Na+(6.66 ± 0.05 and 7.49 ± 0.05), K+(3.40 ± 0.05 and 5.91 ± 0.05), Rb+(3.00 ± 0.05 and 4.23 ± 0.05), Cs+(2.90 ± 0.05 and 4.04 ± 0.05) and Ag+(9.35 ± 0.04 and 14.00 ± 0.05), in acetonitrile and propylene carbonate, respectively, determined by potentiometric titration at 298.2 K and I= 0.05 mol dm–3(NEt4ClO4). Complexes of the parent macrocycle 1,4,7,10-tetraazacyclododecane (L2) are less stable. For the monomolecular decomplexation of [NaL1]+ in acetonitrile and propylene carbonate the values kd(298.2 K)= 78.5 ± 1.0 and 26.1 ± 0.6 s–1, ΔHd‡= 49.2 ± 0.3 and 57.7 ± 0.4 kJ mol–1, and ΔSd‡=–43.7 ± 0.9 and –24.0 ± 1.0 J K–1 mol–1, respectively, were determined by 23Na NMR spectroscopy. Carbon-13 NMR spectroscopy showed that for the enantiomerisation of square-antiprismatic [LiL1]+, [NaL1]+ and [KL1]+ in methanol, ke(298.2 K)= 18 300 ± 3100, 7100 ± 220 and 7010 ± 200 s–1, ΔHe‡= 41.3 ± 1.3, 24.6 ± 0.5 and 53.7 ± 0.6 kJ mol–1, and ΔSe‡=–24.8 ± 5.9, –88.6 ± 1.8 and 8.8 ± 2.3 J K–1 mol–1, respectively. For [LiL1]+ and [NaL1]+ enantiomerisation occurs much more rapidly than intermolecular exchange of L1, but for [KL1]+ enantiomerisation occurs predominantly through intermolecular exchange of L1.


We have developed a standardized methodology to model hohlraum drive in NIF experiments. We compare simulation results to experiments by 1) comparing hohlraum xray fluxes and 2) comparing capsule metrics, such as bang times. Long-pulse, high gas-fill hohlraums require a 20-28% reduction in simulated drive and inclusion of ~15% backscatter to match experiment through (1) and (2). Short-pulse, low fill or near-vacuum hohlraums require a 10% reduction in simulated drive to match experiment through (2); no reduction through (1). Ongoing work focuses on physical model modifications to improve these matches.


We have previously reported radiant energy detection by superconducting thin films in both a thermal (or bolometer) mode and a current mode. We now report evidence that at least some current-mode detection is due to Josephson behavior associated with agglomeration in tin films. The temperature dependence of the critical current agrees with results for Dayem bridges, and we observe microwave-induced steps in the current-voltage characteristics which have the proper dependence on frequency and power. At a constant film resistance the current-mode responsivity shows structure (dips) in its dependence on bias current which shifts with microwave frequency in agreement with the Josephson theory. The films appear to behave like an array of weak links in the "correlated" state as observed by Clark and explained by him and Tilley.


Presentation of Case A 73-year-old man was admitted to the hospital with a diagnosis of a contained, ruptured aneurysm of the left femoral artery. The patient was a retired shipyard pipe fitter, with known exposure to asbestos. He had smoked one pack of cigarettes daily for 30 years and then switched to pipe-smoking 32 years before admission. He also had "chronic bronchitis," which was managed with theophylline, and hypertension, which was treated with enalapril. Ten years before entry a stage B1 carcinoma of the prostate gland was found and was treated at another hospital by radiation therapy with a . . .


The result of water quality and eutrophication assessment indicated that :(1)drawing water from Yangtze River to Taihu Lake did not improve the water quality overall;(2)water quality of part of the Taihu Lake(Gonghu Lake) improved from class Ⅳ to class Ⅲ.(3)although extensive pollution controlling projects begun from 1996 improved TP、TN、CODMn,they were higher than that of 1981,(4)research suggested that to restore water quality of Taihu Lake,pollution controlling and drawing water must be developed at the same time.


In order to solve the problem of large vibration noise,high flow pulsation and simple control mode of the traditional marine pump,this paper proposed a piston pump driven by linear motor. With the linear motor driven piston pump system as the research object,the linear motor driven piston pump working principle of the constant flow was studied and the mathematical model of different motion curve was established. Then,the simulation analysis and experimental test of the linear motor dynamic response for different motion control mode and motion curve were conducted. Experimental results and the conclusions show that the speed planning control program which based on Labview has good controlling characteristics. Servo characteristics of permanent magnet synchronous linear motor can meet the highspeed and high-frequency working requirements of direct-driven reciprocating piston pump. The maximum following error of triangular and S wave velocity curve under PVT motion mode was 87. 5 μm and 91 μm.Either triangular wave velocity curve or S-wave velocity curve,the maximum following error of linear motor under PVT motion mode was less than that of Spline motion mode. It is beneficial to reduce the direct-driven piston pump combination flow pulsation and system vibration. The vibration amplitude of system in the radial direction was weakened by about 70%,and the other direction also had gooddamping effect. A series of vibration experiments demonstrate that the vibration response characteristic of linear motor driven piston pump system is excellent under triangular wave / PVT mode,the vibration of system is greatly weakened.


We read with interest the recent study by Harris et al. (2018). Using data from more than 5000 patients under community treatment order (CTO), the authors found that CTOs were effective in (1) reducing readmission rates, (2) increasing the time to their first readmission and (3) reducing the number of hospital admissions. In the accompanying debate piece, Ryan (2018) draws less optimistic conclusions about the clinical significance of these findings: Ten people would need to be treated involuntarily in the community to avoid one fewer admission, and 48 would need to be treated involuntarily to prevent future readmission for a single patient.


Hilda K. Weisburg, a highly respected and long-standing US commentator, explores the practical and personal ways we can develop our leadership skills for the ultimate benefit of ourselves, our school community and our profession.


The human-oriented idea is a new issue heatedly discussed in the domain of theoretics. The scientific connota- tion of human-oriented idea is firstly examined comprehensively and accurately; secondly, general introduction to the hu- manism of three generations of China's state leaders is provided and the human-oriented idea is proved to be the guiding ideology of China's state leaders.


Describes recent activities in the in-car navigation industry. Focuses on the new "full-bodied" navigation systems which combine map-matching and Global Positioning System (GPS) technologies into a single unit. Reports on the advent of hand-held units which offer a reduction in cost, size and increased availability.


Taxman, F.S., & Thanner, M. (2006). Risk, Need, and Responsivity (RNR): It All Depends. Crime & Delinquency, 52, 28-51. (Original DOI: 10.1177/0011128705281754). Authorship of the article was appearing as "Faye S. Taxman and Meridith Thanner". We have now fixed the correct authorship to read as Faye S. Taxman, Meridith Thanner, and David Weisburd".


The role of the plasma membrane Ca2+ pump (PMCA) is to remove excess Ca2+from the cytosol to maintain low intracellular Ca2+ levels. Asp1080 lies within an acidic sequence between the C-terminal inhibitory region and the catalytic core of PMCAs and is part of the caspase-3 recognition site of isoform 4b. Caspase-3 cuts immediately after this residue and activates the pump by removing the inhibitory region (Pászty, K., Verma, A. K., Padányi, R., Filoteo, A. G., Penniston, J. T., and Enyedi, Á. (2002) J. Biol. Chem. 277, 6822–6829). Asp1080 had not been believed to have any other role, but here we show that it also plays a critical role in the autoinhibition and calmodulin activation of PMCA4b. Site-specific mutation of Asp1080 to Asn, Ala, or Lys in PMCA4b resulted in a substantial increase in the basal activity in the absence of calmodulin. All Asp1080 mutants exhibited an increased affinity for calmodulin because of an increase in the rate of activation by calmodulin. This rate was higher when the inhibition was weaker, showing that a strong inhibitory interaction slows the activation rate. In contrast, mutating the nearby Asp1077had no effect on basal activity or calmodulin activation. We propose that the conserved Asp1080, even though it is neither in the regulatory domain nor in the catalytic core, plays an essential role in inhibition by stabilizing the inhibited state of the enzyme.


Detection of Liver cancer from CT images is an exigent task due to the reason that cancer impression in CT images are of very low in contrast and have indistinguishable edges. Indistinguishable edges are edges in which foreground and background are almost same. Image segmentation is used to extract desired anatomical structure from image. Image segmentation is the process of dividing the image into multiple regions. These regions are sometimes called region of interest (ROI). These ROI's are used as informative inputs to further image processing e.g. feature extraction, selection and ultimately the classification of a disease. Thus an effective image segmentation is utmost important in medical images. In case of indistinguishable edges most segmentation techniques fails to detect edges. Edge based and region based active contour methods are most prevalent for image segmentation. Edge based technique works using gradient function and ultimately stopping function to detect edges , while region based uses average information inside and outside regions to control evolution and termination at edges. In this paper comparative analysis of edge based and region based active contour using level sets is done. When applying these methods on the CT images with an impression of liver cancer, it has been found that the edge based contour able to locate the desired edges more accurately. The quantitative and qualitative results comparison between two techniques has also been done. Results shows that edge based methods performs comparatively better than region based active contour using level set if number of iterations are controlled properly.


process aspires to a momentous significance for otherly forms of life, love, and labor beyond (trans)nationalism. The "archival turn" coined by Ann Stoler in the 1990s presaged an eminently interdisciplinary enterprise. Papailias's theoretically informed ethnography of the forms of historical consciousness skillfully balances between disciplines and, notably, employs linguistics as well as literary/cultural studies to energize the relations between anthropology and history. Its understanding of the versatility of writing modes in particular is matched by the author's own impeccable writing. Its insights are archival in scope; were the reader to take a cue from the case studies, he or she might solely read the book's footnotes and still generate a host of alternative histories.