OBJECTIVE: Acute excitation of a small cluster of excitatory neurons in mouse ventral medial medulla (VMM) produces a phenotype resembling cervical dystonia. This study is to characterize and quantify these dystonia-like neck movements.
 BACKGROUND: Distinct groups of excitatory neurons in the medial medulla differentially affect gait parameters, skilled motor tasks, and posture. These neurons form a relay between forebrain/midbrain/cerebellum and spinal motoneurons that mediate these functions. Abnormal activity in these neurons may cause abnormal movements, including dystonia.
 DESIGN/METHODS: We inserted mutated hM3Dq receptors into small clusters of glutamatergic neurons in the VMM using an adeno-associated viral vector delivered stereotactically. Following transfection, the mutated receptors were selectively and reversibly activated through intraperitoneal injection of an otherwise inert ligand, clozapine-N-oxide (CNO). Movements were quantified with electromyography and video analysis. The location and projections of transfected neurons were determined histologically.
 RESULTS: Acute unilateral activation of VMM neurons induced slow, repetitive neck rotation towards the activated side. Rotation was prominent at rest but not during walking or grooming. Maximum rotation angle, mean duration of each rotation bout, and frequency of long-duration rotation bouts all increased markedly following CNO compared to saline. EMG activity increased in agonist and antagonist neck muscles, and irregular EMG bursts corresponded to fine, jerky movements. The severity of the phenotype correlated with the number of neurons projecting to the upper cervical cord. Wildtype mice and mice with more dorsal injections did not display this phenotype.
 CONCLUSIONS: Unilateral activation of a small cluster of excitatory neurons in the VMM induces a phenotype strikingly similar to that observed in cervical dystonia patients. This cluster may represent an important relay in circuitries that mediate abnormal muscle activation in dystonic neck movements and may be a potential interventional target for cervical dystonia.
 Study Supported by: R01 NS079623; Bachman-Strauss Dystonia & Parkinson Foundation; Fellowship AAN Disclosure: Dr. Ellison has nothing to disclose. Dr. Worley has nothing to disclose. Dr. Samardzic has nothing to disclose. Dr. VanderHorst has nothing to disclose.


In order to investigate the effect of changes in sex hormone binding globulin (SHBG) levels on d-norgestrel (d-Ng) levels in plasma, the plasma levels of SHBG and d-Ng were studied during one treatment cycle in 6 women on oral contraceptives containing d-Ng and ethinyloestradiol (EOe2) and in 3 women using subcutaneous silastic rods containing d-Ng concomitantly taking EOe2 for three weeks. A significant positive correlation between the SHBG and d-Ng levels was found in 7 of the 9 subjects studied. The results provide evidence for an in vivo binding of d-Ng to SHBG, a SHBG influence on the metabolic clearance rate of d-Ng and consequently a dependence of the plasma levels of d-Ng on the SHBG concentrations in the plasma. These findings support the concept that the clinically and biochemically observed anti-oestrogenic/androgenic effects observed in women on d-Ng containing medication are due to a displacement of testosterone from SHBG by d-Ng. Changes in the level of a specific high affinity binding protein for steroid hormones affect the metabolic clearance rate of these hormones (Anderson 1974). An increase in the binding protein leads to a reduction in the metabolic clearance rate which will be reflected in higher plasma levels of the steroid when administered at a constant rate. We have found that d-norgestrel (d-Ng) binds strongly to the sex hormone binding globulin (SHBG) in vitro (Victor et al. 1976). Ethinyloestradiol (EOe2) administration leads to an increase in the SHBG levels in the plasma (Anderson 1974; Briggs 1975a; van Kämmen et al. 1975). The aim of the present study was to investigate if the EOe2 induced changes in SHBG affect the plasma levels of d-Ng. This would provide evidence for an in vivo binding of d-Ng to SHBG. 430 Department of Obstetrics and Gynaecology, University Hospital, S-750 14 Uppsala, Sweden Downloaded from Bioscientifica.com at 11/20/2018 10:28:41AM via free access 50 150/jg d-norgestrel 30/jg ethjnylestradiol 1 5 9 13 17 21 Day of treatment Fig. i. Plasma levels of SHBG and d-Ng in 3 women using oral contraceptives containing 150 fig d-Ng and 30 fig EOe2. MATERIALS AND METHODS The plasma levels of d-Ng and SHBG were studied in 3 groups, each consisting of 3 women. Two groups received oral contraceptives containing 150 fig d-Ng + 30 fig EOe2 or 250 fig d-Ng + 50 fig EOe2, respectively, for three weeks. Blood samples were collected before treatment started and 12 h after the regular intake of each pill during treatment. This time was chosen to avoid the period of absorption after pill intake when the plasma levels are more variable (Weiner et al. 1976). The third group consisted of women treated with d-Ng containing subdermal silastic rods. Their plasma levels of d-Ng had been constant for several months before the start of concomitant treatment with 50 fig of EOe2 for 21 days. Details of all 3 groups and their plasma d-Ng levels have been published elsewhere (Weiner et al. 1976; Weiner Se Johansson 1976). The plasma levels of d-Ng were determined by radioimmunoassay (Weiner et al. 1976). This method measures all unconjugated d-Ng, both bound and unbound. In this study the values have been given in nmol/1 (1 ng/ml = 3.22 nmol/1). SHBG levels in plasma were determined by the method of Rosner (1972) and are expres¬ sed as the dihydrotestosterone binding capacity of plasma in nmol/1. The precision and reproducibility of the method is good with interand intra-assay coefficients of variation of 10 per cent or below. The addition of large amounts of cold d-Ng to plasma does not influence the results of the SHBG determinations. A reference distribu¬ tion of SHBG levels was calculated from the results of SHBG determinations in 68 healthy women, ages ranging from 18 to 43 years, with regular menstruations using an IUD for contraception and in 35 healthy men, with ages ranging from 23 to 40 years.


Abstract Ice recession in the Uppsala region. In connection with mapping for the Geological Survey of Sweden in the Uppsala region drillings were carried out at 17 localities (Fig. 1) through the glacial varved clay in order to discover the ice recession in this area. The device used for drilling was a soil sampler with metal foils, constructed by the Swedish Geotechnical Institute (W. Kjellman and co-workers 1950) and able to take undisturbed samples of lengths up to 11 m. Varve measurements were carried out at all localities and used for connections with each other and with earlier measurements from here by Gerard De Geer (1940). The results are given in the graphs of Plate 3 and 4 and the table of Plate 5. Between all localities, situated in the Uppsala plain and the vallies associated with it, it is possible to find varve connections, but it is nearly impossible to do so in the area W of the town, probably owing to topographical conditions influencing the silty bottom streams of melt water from the ic...


The field experiments were conducted in Brody, near Poznan, during 2011 and 2012 to investigate the effects of time of application and addition of adjuvants on the efficacy of nicosulfuron + rimsulfuron + dicamba and grain yield of maize. The following weed species were investigated Chenopodium album, Fallopia convolvulus, Lycopsis arvensis and Echinochloa crus-galli. Three nicosulfuron + rimsufluron + dicamba application rates were applied with addition of non-ionic surfactant (S), methylated esters (MSO) and ammonium nitrate (AMN). The herbicide mix was applied once at 400 and 200 g/ha, and twice at 170/170 g/ha with S or MSO and AMN. Evaluated adjuvants provided enhancement of control of reduced rates of nicosulfuron + rimsufluron + dicamba for all weeds. MSO was generally slightly greater effective for weed control than S. Nicosulfuron + rimsufluron + dicamba with adjuvants applied twice at reduced rates greatly increased weed control that ranged between 90 and 100%. Twice application of herbicide mixtures with adjuvants provided slight increase, as compared to other treatments, and high increase, as compare to the untreated treatment, of maize grain yield.


Writing formal "journal-style" lab reports is often one of the requirements chemistry and biochemistry students encounter in the physical chemistry laboratory. Helping students improve their technical writing skills is the primary reason this type of writing is a requirement in the physical chemistry laboratory. Developing these skills is an important goal, yet sometimes students are not given enough time to review and revise their writing. Further, they seldom are taught how to review, and thus critical steps in the writing process are omitted. We have developed an approach with the goal of helping students improve their technical writing skills that employs the peer-review process and includes detailed guidance for writing reports in a progressive manner. We present these assignments, how student progress is assessed, and how the components fit to improve the technical writing abilities of the students.


In this paper, I explore the entanglement of school related objects, such as the school bag, and children's identity processes within a Danish school context. As a central institution in the Danish welfare state, school is a formative project shaping future citizens. Consequently, school is a social and cultural context in children's lives and a context for children's identity processes. Furthermore, increased parental involvement in children's school has an impact on children's everyday lives as school is extended into the family. Based on ethnographic research on children's school day and navigations in school-home relations I address the way school is experienced and affects children's identity processes and the role school bags play in such processes. More specific, I examine how the school bag becomes a sensitive object evoking certain feelings regarding school. This happens in two interconnected ways. In children's use of their school bags and in the way school bags becomes an object for parental involvement, and a tool for adult monitoring of children. By addressing these issues I emphasise how experiences of school as something comfortable or uncomfortable is materialised through the school bag (and other objects) and becomes part ongoing processes of shaping identities as a poor or good student. Inspired by materiality studies (e.g. Miller 2008, 2009, Frykman & Frykman 2016) as well as anthropological childhood studies, the paper addresses questions of childhood, affect and materiality in ethnographic research within the field of education.


. Atak-S laying hens are a high-performance hybrid obtained by crossing of the Rhode Island Red (RIR) X the Barred Plymouth Rock (BR) and are being produced in the Ankara Poultry Research Institute since 1997. Pheno-typic and genetic improving studies are continuous for this hybrid. In this study three different SNPs, two from IGF 1 and one from IGFBP2 genes, were examined in 150 Atak-S chickens. Genetic association of SNPs were compared to body weight and egg number till 32 weeks of age, body weight at sexual maturity, age at sexual maturity and also egg quality traits such as egg shell breaking strength, shell thickness, Haugh unit, albumen index, yolk index and shape index were statistically analyzed. Only IGF1 (a) locus was in agreement with Hardy-Weinberg equilibrium, while, the rest of the loci were not. As a result of the comparisons performed to the three SNPs, it was determined that there was a significant association (P<0.05) between the T364C haplotypes of the IGF1 (b) locus and body weight at 32 weeks of age, but there was not any association to the other traits.


Resource Description Framework (RDF) is a graph-like data model designed for the web. One of its compelling features is a precise, model-theoretic semantics. We address security in the context of the RDF. We rst observe that the problem of securing RDF is related closely to the more traditional problem of securing graphs. Consequently, before we address security for RDF, we make broader contributions to security in the context of graphs. Speci cally, we reconcile four di erent notions of security that have been proposed in prior work, and compare them from the standpoint of strength of security whether satisfaction of one implies satisfaction of another. We then ask whether strength of security is correlated to computational complexity. We make the somewhat surprising observation that the answer to this question is, no. We then extend the two strongest notions of security in a natural way for RDF. We establish results on RDF's semantics that then gives us a way of meaningfully quantifying the loss of information from security. Thus, for RDF, we are able to pose the natural trade-o between information-quality and security in a precise way. We show that a corresponding decision problem is NP-complete, and with a reduction to Cnf-Sat that we have designed and implemented, present empirical results on realistic data. Our empirical results show interesting relationships between the various parameters, such as the size of the graph versus the information-loss, to achieve a particular level of security.


Guinea pigs are a popular pet choice and are often encountered in veterinary hospitals, as they are susceptible to husbandry and stress-related conditions and do not readily show the early stages of an illness. Consequently, they are often presented in a critical condition and requiring 'life-saving' treatments which can be challenging, mainly owing to their stoic yet easily stressed nature. A full physical examination will allow for priorities in the treatment plan to be determined, and species-specific considerations could improve patient care. Veterinary nurses should be encouraged by their team to pursue developing skills in clinical techniques such as venepuncture, to ensure efficient relief from suffering. Consequently, nurses can play a vital role in applying the initial critical care and therapies such as heat, fluids, oxygen and nutritional support. This article aims to review the relevant characteristics of guinea pigs as patients and their commonly encountered critical illnesses. Part two of th...


Objective To evaluate the application of antipsychotic treatment of schizophrenia status and trends of clinical treatment in the past 4 years in our hospital.Methods Make a retrospective analysis of patient data those were suffering from schizophrenia and were treated whit antipsychotics,Calculate the sales amount of DDDs(DDDs) of different kinds of antipsychotics and sorting index.Results In 2007 to 2010 oral taking anti insane amount of drug consumption was rising trend;2007 to 2010 in our hospital the value of antipsychotics DDDs upward trend;Top three of Consumption in our hospital the amount of antipsychotics were Olanzapine tablets,risperidone,quetiapine.Conclusion Summary of usage of antipsychotics in 07 to 10 years can learn Clinical characteristics and treatment needs of patients.To assess the rational use of antipsychotics,scientific management and scientific basis to develop new products and ideas.


Central Java is one of the provinces in Indonesia where most people live cultivating.
This study aims to determine the effect of education level, population, and minimum wage of
regency / city (umk) in Central Java in 2013-2014.
The results showed that: The level of education and the number of population has
no significant effect on the absorption of agricultural workforce, the minimum wage of
regency / municipality has a positive and significant effect on the employment of agricultural
sector.


Recently, professional baseball watching is expected to be the industry attracting many customers to the city, and it is important to know its feature. In this study, their features and economic effect are analyzed by questionnaire survey for the spectators of Fukuoka Softbank Hawks(baseball team). The following things became clear by this research. 1) The consumptionof the person who came alone or from a distant place is expensive. 2) Before and after watching the game, the spectators drop in the places except Fukuoka Dome (baseball stadium), and Fukuoka Dome is contributing to the bustle of a city. 3) Big demand is produced also to the industries which aren (cid:182) t directly related to professional baseball watching. 4) Attracting customers is greatly influenced by the traffic cost. Therefore, professional baseball watching has the big influence that cannot be disregarded on the urban economy.


This book explores the power of using media education to help urban teenagers develop their critical thinking and literacy skills. Drawing on his twenty years of experience working with inner-city youth at the acclaimed Educational Video Center (EVC) in New York City, Steven Goodman looks closely at both the problems and possibilities of this model of media education.


Telecommunications service providers (TSPs) previously provided network functions to end users with dedicated hardware, but they are resorting to virtualized infrastructure for reducing costs and increasing flexibility in resource allocation. A representative case is the Central Office Re-architected as Datacenter (CORD) project from AT&T, which aims to deploy virtualized network functions (VNFs) to over 4000 central offices (COs) across the U.S. However, there is a wide spectrum of options for deploying VNFs over the COs, varying from highly distributed to highly centralized manners. The former benefits end users with short response time but has its inherent limitation on utilizing geographically dispersed resources, while the latter allows resources to be better utilized at a cost of longer response time. In this work, we model the TSP's virtualized infrastructure as hierarchical datacenters, namely hierarchical CORD, and provide a resource allocation solution to strike the optimal balance between the two extreme options. Our evaluations reveal that in general, the 3-tier architecture incurs the least cost in case of deploying VNFs under moderate or loose delay constraints. Furthermore, the margin of improvement on the resource allocation cost increases inversely with the overall system utilization rate. Our results also suggest that as heavy request load overwhelms the network infrastructure, the relevant VNFs shall be migrated to lower-tier edge datacenters or to some nearby datacenters with superior network capacity. The evaluations also demonstrate that the proposed model allows highly adaptive VNF deployment in the hierarchical architecture under various conditions.


Macro- and micromorphological characters of the seeds of 32 species belonging to Aizoaceae (26 species), Gisekiaceae (one  species)  and  Molluginaceae  (five  species)  were  analysed  for  their  taxonomic  value.  Seed  morphology  is  found to be of considerable taxonomic value within the taxa investigated, although additional criteria are usually necessary for distinguishing the species. However, a subgroup of Trianthema, consisting of T. cussackiana, T. megasperma, T. pilosa, T. rhynchocalyptra and T. oxycalyptra var. oxycalyptra (Aizoaceae) shares the synapomorphy of seeds with scattered idioblast cells (papillae). There is little infrageneric variation within Sesuvium and Zaleya in contrast to Trianthema, whose seeds are considerably polymorphic. The fairly different seed structures found in Aizoaceae s.s. and Molluginaceae support their treatment as two distinct families. However, the position of Lineum (Molluginaceae) remains uncertain. Moreover, seed characters support the independence of Gisekia (Gisekiaceae) in a family of its own. © 2005 The Linnean Society of London, Botanical Journal of the Linnean Society, 2005, 148, 189–206.


Structural dependence on annealing of a-SiOx:H was studied by using infrared absorption and Raman scattering. The appearance of Raman peaks in the range of 513 - 519 cm-1 after 1170 degree(s)C annealing was interpreted as the formation nanocrystalline silicon with the sizes from 3 - 10 nm. The Raman spectra also show the existence of amorphous-like silicon phase, which is associated with Si-Si bond re-construction at boundaries of silicon nanocrystallites. The presence of the shoulder at 980 cm-1 of Si-O-Si stretching vibration at 1085 cm-1 in infrared spectra imply that except that SiO2 phase, there is silicon sub-oxide phase in the films annealed at 1170 degree(s)C. This sub-oxide phase is located at the interface between Si Crystallites and SiO2, and thus support the shell model for the mixed structures of Si grains and SiO2 matrix.


A multiple quantum well (MQW) structure for the light emitting diode, to provide a method of fabricating an MQW structure for a light emitting diode. MQW structure comprises a plurality of quantum well structures, each quantum well structure, a barrier layer and, and a well incorporating a quantum dot structure is formed on the barrier layer layers, one of these barrier layers and the well layers are first comprising a metal nitride based material, at least one quantum well structure further comprises a capping layer formed on the well layer, the capping layer is different compared to the first metal nitride based material comprising a second metal nitride based material having a metal element. .FIELD 1


The authors recently published a nonsignificant meta-analysis of 30 extrasensory perception ganzfeld studies, all conducted after the 1986 publication of important methodological guidelines aimed at reducing sources of artifact noted in earlier studies. In response, L. Storm and S. Ertel (2001) presented a meta-analysis of 79 studies published between 1974 and 1996. They argued that the positive and highly statistically significant overall outcome indicates a replicable paranormal effect. In doing so, they ignored the well-documented and widely recognized methodological problems in the early studies, which make it impossible to interpret the results as evidence of extrasensory perception. In addition, Storm and Ertel's meta-analysis is not an accurate quantitative summary of ganzfeld research because of methodologica l problems such as their use of an inconsistent method for calculating study outcomes and inconsistent inclusion criteria. Storm and Ertel (2001) presented a meta-analysis of ganzfeld studies, which, they argued, provides strong evidence of a replicable and genuine communication anomaly. We disagree both with their conclusion and their view of the role of methodologica l quality in attempts to resolve whether extrasensory perception exists. In this article, we discuss the problems in the early ganzfeld studies that make it difficult to draw strong conclusions from meta-analyses such as Storm and Ertel's that include them, additional problems in Storm and Ertel's meta-analytic approach, the general difficulties in using meta-analysis to identify and correct for methodological problems in constituent studies, and a possible approach to the replication problem within parapsychology.


We study Maldacena's conjecture and the AdS/SYM correspondence on the Coulomb branch. Several interesting aspects of this conjectured AdS/SYM correspondence on the Coulomb branch are pointed out and clarified.


In studying 150 cases of gastric cancer, 93 (62%) were found to be CEA‐positive. Among them, 5 cases had concurrent elevation of serum AFP over 200 ng/ml and appearance of serum CPALP. Further, there were another 2 cases simultaneously positive in serum CPALP. All these 7 cases were of pathologically well‐differentiated adenocarcinoma with liver metastases.


I hope to argue that the respective projects of Popper and Kuhn differ so significantly largely because of their divergent purposes. Furthermore, I find myself seeing the differences between the two as, in some senses, indicative of the differences between science education at Shimer and science education in the traditional sense.


DNA double strand breaks are the most dangerous type of DNA damage. The MRN complex and 53BP1 have essential functions in the repair of DNA double strand breaks and are therefore important for maintaining genomic stability and preventing cancer. DNA double strand breaks are repaired by two main mechanisms homologous recombination and non-homologous end joining. The MRN complex senses DNA double strand breaks and activates a cascade of posttranslational modifications that activates and recruits other effector proteins. In addition MRN mediated resection is important for removing adducts in non-homologous end joining and creating single stranded DNA required for homologous recombination. 53BP1 is recruited to DNA double strand breaks by site specific ubiquitinations and inhibits DNA resection, thereby promoting nonhomologous end joining at the expense of homologous recombination. In this thesis we show that MRE11 binds to the R2TP chaperone complex through a CK2 mediated phosphorylation. Knockdown of R2TP or mutating the MRE11 binding site leads to decreased MRE11 levels and impaired DNA repair. Similar phenotype has been observed in cells from patients with ataxiatelangiectasia-like disorder (ATLD), containing MRE11 deletion mutation which is missing the R2TP complex binding site. Based on R2TP complex function as a molecular chaperone, we conclude, that R2TP complex is important for MRN complex assembly/quality control. Moreover, we explored the processes important for regulating localisation of DNA repair protein 53BP1 to the nucleus and DNA damage site. We investigated PLK1 and CDK1 mediated phosphorylations in 53BP1 ubiquitin binding domain and discovered that they inhibit 53BP1 recruitment to the DNA damage site in mitosis. Finally we discovered the sequence of 53BP1 localisation signal and explored regulatory mechanisms of 53BP1 nuclear localisation by post translational modifications. In conclusion, we deepened our understanding of MRN complex assembly and pathophysiology of a specific MRE11 mutation leading to ATLD. In addition we found new ways of regulation of 53BP1 localization and function.


A guide to make the triple point cell of water for calibrating precise thermometers with an accuracy of 0.1 mK is studied from a practical point of view. The triple point cell of water can be made by a simple method of filling it with usual distilled water of ∼105 Ω·cm in resistivity under ordinary atmosphere and then degassing the water by pumping at 40°C for an hour, degassing result being assumed by observing no bubbles of air in the ice mantle made immediately after sealing the cell.


This article presents the Parabolic-Monge-Ampere (PMA) method for numerical solutions of two-dimensional fourth-order parabolic thin film equations with constant flux boundary conditions. We track the PMA technique, which employs special functions to acclimate and force the mesh moving associated with the physical PDE representing the thin liquid film equation. The accuracy and convergence of the PMA approach are investigated numerically using a one two-dimensional problem. Comparing the results of this method to the uniform mesh finite difference scheme, the computing effort is reduced.


The term of caixue novels(novels characterized by their display of the author's academic accomplishments and artistic talents) originated from Lu Xun's interpretation of the history of Chinese novels,but it usually encounters two problems when regarded as a name of a genre in novel creation.To display academic accomplishments is a new development of novel writing in the Mid-Qing Dynasty,the emergence of which is caused by at least the following three factors: 1) to make a more effective narration;2) to realize the author's life value;3) to preserve the author's academic achievements.The caixue novels reflect a change of attitude towards novels among men of letters in that period,which is an inevitable consequence of the development of Chinese vernacular novels.Novels intended to display the author's academic accomplishments are a valuable creative attempt in the history of Chinese fictions.


It has been well known that acetylenic compounds react with cobaltcarbonyl and give benze derivatives via cyclic intermediate (II). The authors found that a new complex compound (IV) wa formed in the reaction of propargyl undecynoate with cobalt carbonyl. The structure of (IV) was identified by molecular weight measurement, elementary analysis and on the basis of the following information : (a) (IV) (1 mole) was formed by the reaction of propargyl undecynoate (1 mole) and cobaltcarbonyl (2 moles) at room temperature in n-hexane with evolution of 4 moles of carbon monoxide. (b) (IV) (1 mole) was decomposed by iodine with the evolution of 12 moles of carbon monoxide. (c) (IV) was decomposed by iodine or CrO3, and propargyl undecynoate was given. (d) (IV) was decomposed by the hydrogenation at 80°C for 24 hrs over Pd-alumina (5%) to give propyl undecanoate. (e) The i.r. spectrum of (IV) showed the absorptions at ca 2000cm-1 due to terminal carbonyl groups and no absorption at ca 1860cm-1 of bridged carbonyl group. (f) The n.m.r. spectrum of (IV) exhibited a proton signal at 6.5τ attributable to methine proton.


The photochemistry of 1,2-benzisoxazole (1) was studied using low-temperature matrix isolation coupled with infrared spectroscopy and quantum chemistry calculations. We identified, for the first time, spiro-2H-azirine 2 and ketenimine 3 as intermediates in the photoisomerization of 1 to 2-cyanophenol (4). These results constitute indirect evidence for the existence of vinylnitrene intermediates in the photochemistry of 1,2-benzisoxazoles. The potential energy surface (PES) resulting from the N–O bond cleavage of 1 was compared with the


19.16 MB Free download Turn Coat: A Novel of the Dresden Files book PDF, FB2, EPUB and MOBI. Read online Turn Coat: A Novel of the Dresden Files which classified as Other that has 464 pages that contain constructive material with lovely reading experience. Reading online Turn Coat: A Novel of the Dresden Files book will be provide using wonderful book reader and it's might gives you some access to identifying the book content before you download the book.


The tobacco is a drug used globally and considered by the World Organization of Health (1985) as the main cause of avoidable illnesses and disabled. This study was accomplished with 5.057 students of public and private schools that filled out solemnity-applicable and anonymous questionnaire. The prevalence of the experimentation was shown elevated among the students 36,2% (1827). The students' age group which more tried tobacco was from 14 to 16 years, completing a total of 53,6% (936). This substance has been tried among 1732 students being 54,4% (943) female students and 45,6% (789) male. The study demonstrated a precocious beginning of the behavior for the tobaccoism, especially when the family relationships were fragile. The pointed results indicated the need of united actions with involvement of the school, family and society, aiming at the prevention of the experimentation of the tobacco and consequently of its use and abuse. The study was approved by the Committee of Ethics of Passo Fundo University,


for program and website: With the expansion of online education, chairs and deans must formulate new strategies for evaluating online course development and instructional delivery. Four chairs (of Business, Education, Sports & Exercise Science, and Psychology Departments), and their dean, will share quality strategies for defining course criteria, developing quality course design, and delivering valued instruction. Presentation Objectives: 1. Provide a framework for assessing quality course evaluation 2. Discuss approaches to evaluating online faculty delivery 3. Examine how online development impacts online delivery Presentation Description: Have you asked yourself: (1) How do I effectively evaluate a faculty member's online delivery? (2) How do I check for quality instruction within the online learning environment? (3) How do I measure online course development and delivery? (4) How can I provide online instructors with pedagogical, technical, and curriculum support? or (5) What are realistic quality performance expectations for online faculty? These questions are increasingly critical with the shift of traditional learning to online platforms. Online education allows learners improved flexibility and expanding options for continued education; however, this shift requires administration to adapt the means by which faculty are evaluated for their teaching efforts. Using face-to-face methods for evaluating online teaching is akin to hammering a square peg in a round hole; these pieces do not fit and fail to address unique dynamics specific to online education. An instructional evaluation tool designed for online education will help facilitate student engagement and allow faculty to connect teaching efforts with instructional competencies. Departments and schools will benefit by establishing clear strategies and standards for how online instruction should be provided. Instructional delivery evaluation tools can be effective and strategic methods for achieving positive student-instructor engagement as well as institutional growth. Aligning the faculty instructional development and delivery goals with the strategic goals of the department or school will help connect development/delivery expectations to a university's larger strategic plan. Additionally, providing faculty with development and delivery expectations allow instructors to better meet teaching expectations. This presentation will examine key components of evaluating online design and delivery and discuss how to operationalize key components of online instructional evaluation including: (1) creating instructional guidelines; (2) developing meaningful discussions or peer-to-peer contact; (3) providing multiple levels of information, evaluation, and acknowledgement feedback to students; (4) establishing and effectively communicating assignment deadlines and expectations; (5) creating communication and teaching channels resulting in a positive learning community and interactive environment; and (6) valuing the diverse learning methods of students. Utilizing a design/delivery tool unique to the online environment will foster improved evaluation of online curriculum and the facilitation of quality instructional delivery.


MicroRNAs (miRNAs) are small RNA molecules that target particular genes and prohibit their expression. Since many important diseases are related to the expression or non-expression of particular genes, knowing the miRNAs that affect these genes can help in finding possible treatments. In the last decade, a large amount of experimental studies trying to reveal the targets of several miRNAs has been published. A handful of curated databases that collect miRNA targets from the literature have been developed to make this information more easily available. However, due to the large number of existing published articles, maintaining these databases up-to-date is a tedious task that requires important resources. In this work we introduce TarMiner, a pipeline for automatic extraction of miRNA targets that can facilitate the curation process of databases that maintain miRNA validated targets.


worries about Communist expansion in Southeast Asia, these fault lines within the Communist world not only prevented the 1961 Laos agreements from being implemented but also spoiled any chance for a negotiated settlement in Vietnam. Together with Qiang Zhai's China and the Vietnam Wars, 1950–1975 (Chapel Hill: University of North Carolina Press, 2000), Gaiduk's book alls a wide gap in the historiography, which hitherto tended to overlook the central roles Moscow and Beijing played in the unfolding Vietnam War. Gaiduk also rectiaes the faulty impression, often promoted in the Chinese literature on this topic, that Moscow was merely an appendix to Beijing's Vietnam policy. Although Gaiduk conducted extensive research in the Russian archives, especially in the foreign ministry archive (AVPRF) where access to materials from the 1950s is better than for any subsequent period, he was unable to use the most important ales (Khrushchev and the Presidium, for example) in the presidential archive (APRF) and the two central party archives (RGASPI and RGANI). He thus went to great lengths to use other available sources, such as archival material in Washington, DC and London; published Russian-, English-, and French-language document collections; and the newest secondary literature. Research in the Russian-language holdings of some key East European party archives, as I discovered when working on Soviet relations with China during the same period covered by Gaiduk, might have provided important additional documentary evidence. But this is a minor point, which does not lessen Gaiduk's achievement. The organization of the book is sound, and the writing is clear. Gaiduk presents his main argument well and provides extensive support with much previously unseen evidence. The inclusion of Laos and, to a lesser degree, Cambodia as well as the use of Western archival material provides the reader with far more than just a narrow account of Moscow's policy toward Hanoi. Gaiduk's book is a major contribution to our understanding of one of the most destructive conoicts after World War II and will be warmly received by experts, university students, and the wider audience beyond.


Summary A method has been described for the determination of the total numbers of bone marrow cells in the rat femur. Administration of corticosterone to adrenalectomized rats results in significant increases in the numbers of nucleated erythroid cells and decreases in the numbers of neutrophils and eosinophils within femoral marrow.


Near-field scanning of phased arrays and other antennas traditionally use mechanical scanning techniques that are relatively slow. Switched probe arrays have been used to remove the positioning time for at least one axis of motion, but still suffer from various limitations. Recent advancements in phased array design and calibration methods offer an alternative with potentially near-instantaneous capture of near-field data using digital coding techniques. This paper will investigate the technique and several variations of possible implementations.


The morphologies observed on layers of III-V compounds and their alloys grown by Liquid Phase Epitaxy (LPE) are reviewed; these include: facets, terraces and the effect of small misorientation of the substrate; effects due to both the moving and the static three-phase boundary line on the surface of the crystal; nucleation effects; and the effects of insoluble particles in they solutions.


The effect of metal electrodes on high frequency vibrations of plates has to be carefully considered in the analysis and design of quartz crystal resonators. Extensive studies have been done in the analysis of various electrode configurations, including the symmetric, asymmetric, and layered structures to predict the exact frequency and mode shapes which are important in the estimation of resonator properties and the optimal design parameters for the fundamental thickness-shear vibration mode. Through practical experiences, it is evident that the electrode structure has much stronger effects on the overtone vibrations of quartz crystal plates and resonators, but analytical solutions based on a simple physical resonator model have not been examined in earlier studies. In this paper, we start from the usual ideal model of an AT-cut quartz crystal plate covered by metal electrodes, and frequency equations, which have been obtained in earlier studies with and without the consideration of piezoelectric effect, are evaluated with known parameters to observe the changes of the vibration frequencies of different overtone modes and deformation. From calculation, it is clear that the frequency change is much large for overtone modes in comparison to the familiar fundamental vibrations of most quartz crystal resonators. The formulation can also be extended to consider the thermal effect of electrodes for the study of frequencytemperature relation of higher-order overtone modes. It is expected that by solving the familiar equations for frequency under the complication of electrodes at higher-order overtone frequencies, we should be able to refine and establish a procedure for the analysis and design which has been overlooked due to the complexity of the problem and lack of demands, which is now being promoted by the elevated frequency and miniaturization of resonators related to energy consumption reduction.


Reflection on the Phenomenology as a research approach in the scenario of Brazilian Nursing knowledge production and the possibility of developing sustained studies in philosophical and theoretical conception of the thought of Martin Heidegger. Describes the research mode and comprehensive hermeneutic analysis and methodical issues of interest to the epistemological field of qualitative studies.


We present basic facts about electron lenses used in high-energy accelerators and discuss their possible application in the LHC. Four proposals are presented: (a) electron lenses for compensation of head-on beam-beam effects; (b) electron lens as tune-spreader for better beam stability; (c) as electromagnetic primary collimator for ions and protons; (d) satellite bunch cleaning by electron lenses. Main requirements are discussed.


To screen the tobacco varieties with stronger adaptability in Pu'er region to promote the development of specialized high-quality tobacco,the differences in growth duration,agronomic traits,economic characteristics(yield,output value and high quality leaf ratio),resistibility and tobacco leaf quality of four new flue-cured tobacco varieties(KRK26,KRK22,KRK23,T27) were compared in Jingdong County,Pu'er City.The results showed that the variety with shortest field growth duration was KRK26 with stronger resistance to fertilizer and maturity and better appearance quality.At the same time,the yield,output value and high quality leaf ratio of KRK26 were highest,reached to 1 772.5 kg/hm2,25 808.18 yuan/hm2 and 52.46 %,respectively.All varieties demonstrated the resistance to black shank disease,bacterial wilt,angular leaf spot,root knot nematode,CMV and PVY.In addition,KRK26 also demonstrated the resistance to TMV.Therefore,KRK26 has stronger potential of extension in Pu'er region.


The present invention provides a drum for a load handling machine, the drum allowing a rope to be wound therearound in multiple layers such that the windings are parallel to each other. Convex-shaped guide sections (12) for supporting and guiding a rope are arranged at predetermined intervals on the surface of a circular cylindrical drum body (11) so as to extend in the circumferential direction thereof. The guide sections (12) are formed to have a circular arc cross-sectional shape having a curvature radius greater than or equal to the radius of the rope. Supports (13) for supporting the rope are provided between the guide sections (12).


AbstractThe introduction of the 10 mSv.h−1 at 3 m limit for LSA unshielded material makes it impossible to transport, as LSA material, the highest radiation level wastes from EdF PWR's operations. At present, the EdF's waste blocks can be transported as LSA III material by special arrangement. A new package design, equivalent to a Type B package, will be available for their transport before the end of the year 1995. It consists of a re-usable steel cylinder over-packing each block. Compliance of this package model with transport safety requirements will be demonstrated by taking into account the non-dispersability, as LSA III material, of the irradiating waste. The transport of LSA combustible material is affected, in the revised regulation, by the new limitation to 100 A2 of the total activity per conveyance. Complying with this limit would greatly reduce the quantity transported by conveyance and therefore multiply the number of journeys, which is not desirable. A two-step approach has been accepted by ...


This paper considers the responsibility of the connected corporation. It highlights a dissonance between the connectedness of social and material relationships that form corporate-profit streams, and the comparable detachment of the company from negative externalities, crises and systemic harms. The latter often persist awkwardly in connective networks, as events without a clear story in terms of origins, causal forces or responsible actors. It is the aim of this article to learn more about this apparent void in the case of the global corporation, against the background of ever more intense pressure for the 'responsibilisation' of corporate actors for longer range harms. Relevant patterns of corporate detachment are broken down, in the article, into three stages that implicate the company and its governance processes, all of which begin with the letter 'D'. The 'D's concern the 'dissipation', 'diversion', and 'displacement' of responsibility over time. The paper seeks to transform corporate responsibility projects by highlighting the limits on social mobility that patterns of corporate detachment, once ingrained, can bring. It comments on why longer-range (social) obligations are necessary in order that companies might grow their fair share of responsibility for the state of our world.


In this paper, we characterize all nonbinary sequences of length <inline-formula><tex-math id="M2">\begin{document}$ n $\end{document}</tex-math></inline-formula> with nonlinear complexity <inline-formula><tex-math id="M3">\begin{document}$ n-4 $\end{document}</tex-math></inline-formula> for <inline-formula><tex-math id="M4">\begin{document}$ n\geq9 $\end{document}</tex-math></inline-formula> and establish a formula on the number of such sequences. More generally, we characterize other finite length nonbinary sequences with large nonlinear complexity over <inline-formula><tex-math id="M5">\begin{document}$ \mathbb{Z}_{m} $\end{document}</tex-math></inline-formula>.


Morbidity of myocardial infarction is increasing.Owing to the lack of replacement of necrotic cardiac myocytes,the therapeutic methods today are not sufficient to prevent left ventricular remodeling.However,the current insights into stem cell have opened up new perspectives for the infracted heart.Varied stem cells,including embryonic or foetal stem cells,myoblasts,and bone marrow stem cells,have been used for(cellular cardiomyoplasty.The review discusses recent animal experimental data and the clinical potential of varied stem cells.


The stability problem of continuous time positive switched systems composed of unstable subsystems is investigated. By taking advantage of the invariant subspace theory and an assumption, the sufficient stability criteria for positive switched systems with designed periodic switching is presented. Besides, a necessary condition is also proposed with certain hypothesis. Finally, numerical examples are given.


Religious dogma and the ritual of confession are analyzed in six plays by Carlos Solorzano: Mea culpa, El sueno del angel, El zapato, Dona Beatriz (la sinventura), El hechicero, and Las manos de Dios. The treatment of these themes in this theater exemplifies Michel Foucault's writings on discourse and power as expressed in his 1976 Histoire de la sexualite. The confessional rite is depicted as an instrument of repression used by the church to secure power and to affirm its superior position in the social hierarchy of the Americas. These plays challenge the deceptive practices and the underlying motives of the patriarchal institutions that dominate Latin American society and suppress the individual. (TPR, in Spanish)


The embodiment of the invention discloses a thermoplastic polyurethane cable sheath material and a preparation method. The thermoplastic polyurethane cable sheath material comprises following components in parts by mass by taking 100 parts of thermoplastic polyurethane TPU as a cardinal number: 1-5 parts of a light screening agent, 0.1-10 parts of an ultraviolet absorber UVA, 0.05-0.5 part of a hindered amine ultraviolet light stabilizer HALS and 0.1-1.0 part of an antioxidant. Through a comparison test, the anti-UV aging performance of the thermoplastic polyurethane cable sheath material provided by the embodiment is better than that of a currently applied thermoplastic polyurethane cable sheath; the thermoplastic polyurethane cable sheath material provided by the embodiment can be directly processed into a cable sheath for one time by a cable sheath extrusion molding production line; the preparation method is simple to machine, high in production efficiency and energy-saving; the damage on TPU resin molecules is small.


This study investigated the relationship between years practicing the Transcendental Meditation (TM) technique and EEG alpha coherence in 37 undergraduate and graduate students from Maharishi International University (M/U). The subjects, 28 males and 9 females, had been practicing the TM technique for various lengths of time, between 2 and 13 years (X=6.77). The average age of the students was 26.46. Subjects were tested for EEG coherence as part of MIU' s psychophysiological testing program. All measures were monitored simultaneously with the mean coherence scores being derived from ten .53 -minute periods during which all subjects practiced the TM technique. Pearson product-moment correlations were computed to determine the relationship between years meditating and frontal (F3, F4), left (F3, C3), right (F4, C4), and overall (F3, F4, F3, C3, F4, C4) EEG alpha coherence. Frontal, left, and overall EEG alpha were found to be positively correlated with years meditating ( p <.05), and right EEG alpha was not found to be significantly correlated; (frontal, r =.336; left, r =.466; right, r =.283; and overall, r =.423). The above correlations were still found to be significant after partialing out the age of the subjects. In addition, JQ was found not to correlate significantly with EEG coherence. The results of this study indicate that the TM technique is a viable technology for enhancing EEG alpha coherence.


In the field of urology, therapeutic triumphs have been produced d uring the past three decades against testicular cancers, genitourinary rhabdomyosarcomas, and Wilms' tumors. Has progress been made against vesical neo plasms? What has the shift of emphasis toward a surgical attack accomplished? Is it justified to promote another shift in treatment now? Methods for diagnosis and prog nosis of vesical neoplasms have clearly improved during these years, but such are only incidental within the scope of this presentation. Here we try to assay the overall effect of whatever therapy has been prescribed over about 40 years. Has progressbeen made againstthe cancerousprocess itself, or are all improvements more related to betterment in supportive techniques? All patients here itemized have had biopsies revealing primary vesical neoplasms. As a first step, we have corn pared a recent series with an earlier series, using essentially all cases from that particular time regardless of treatment or the lack of it. Later these comparisons will be broken down according to certain classifications and selections. The re cent series was composed of all cases at The New York Hospital-Cornell Medical Center from 1960 to 1971 inclu sive. The early series was from The New York Hospital and The Memorial Center beginning with all cases of cancer from 1932 to 1938 inclusive, with an addition of papillomas consecutively collected at The Memorial Center from before 1955 which seemed necessary to round out a full spectrum of these neoplasms (3, 5). We do not consider histologically benign papillomas as carcinomas. The papillomas were already tabulated separately and were added as a facilita tion, although they were not precisely of the same vintage (4). The groups are not absolutely comparable even in chro nology, but we believe they are sufficiently comparable to provide valid information. An apparent discrepancy in dates stems from the fact that the date when these patients were actually given their treatments is not the same as that at which they were evaluated; for example, those reported in 1956 were treated in 1951 and before. There was a contro versy concerning my report on this point in 1947 (3). Conse quently, a professional statistician rechecked the data and confirmed the figures essentially unchanged (1). The ex pectancy in the general population for survival 5 more years from the age of 59 (the average age of our groups) is now 91%, up from the 88% when our studies first began (3). The expectancyfora survival of5 yearswithlittle orno therapy has been reliably estimated as 5% (6). Tables 1 and 2 reveal that the gross figures of survival between the 2 groups have remained essentially the same. The difference to be noted in


Knowledge of the changes in physiological traits associated with genetic gains in yield potential is essential to improve understanding of yield-limiting factors and to inform future breeding strategies. Our objective was to identify physiological traits associated with genetic gains in grain yield of winter wheat (Triticum aestivum L.) in the UK. The growth and development of eight representative cultivars introduced from 1972 to 1995 (one tall rht-D1b cultivar and seven Rht-D1b, formerly Rht2, semidwarf cultivars) was examined in field experiments at Sutton Bonington in 1996-1997, 1997-1998, and 1998-1999. A linear genetic gain in grain yield of 0.12 Mg ha(-1) yr(-1) (1.2% yr(-1)) was positively correlated with both harvest index (HI) and aboveground biomass; a quadratic function fitted to the data showed that progress in HI was most apparent during the earlier phase of the 23-yr period, whereas biomass contributed most since about 1983. There was a linear increase across time of 217 grains m(-2) yr(-1), but no change in grain weight. Significant genetic changes across time and correlations with grain yield were also found for preanthesis radiation-use efficiency (RUE, 0.012 g MJ(-1) yr(-1)) and water soluble carbohydrate (WSC) content of stems and leaf sheaths at anthesis (4.6 g m(-2) yr(-1)). Our results suggest that recent genetic gains in grain yield have been based on a combination of improved growth rate in the preanthesis period, which has driven increases in number of grains per square meter, and a larger source for grain filling through increases in stem soluble carbohydrate reserves.


The extrusion/ spheronization technique makes a notable contribution to the existing range of pharmaceutical forms, especially in the area of oral controlled-release product. Analysis of this technique leads the authors to make a parallel study of the influences of the aspects linked to formulation (water content) and to processing used (extruder screw speed) with the aim of optimizing the product quality. Textural variables, porosity, saturation degree and water content were monitored throughout the elaboration process. The kneading operation brings the material to a state in which porosity is linked to water content. The extrusion operation densities the material to saturation point, while spheronization is simply a shaping process which maintains the hygrotextural state. Also emphasized is the presence of solid/liquid ratios optimizing pellet quality independently of the operating variables. In parallel to this, a range of water content for which the influence of the process parameter is relevant is identified.


ABSTRACT Tumors – the plant hyperplasia symptoms- - induced by speciesof Agrobacterium sp. have deeply impressed plant pathologists sinceearly 20 th Century when Erwin Smith and his co-workers demonstratedthat such tumors had a bacterial etiology. Nevertheless, until recentlythe state of art of Microbiology and Molecular Biology was notdeveloped enough for scientists to realize and to elucidate thecomplexes biochemical, genetic and physiologic mechanisms by which Romeiro, R.S.;Vieira Junior, J.R.;Brommonschenkel S.H. Tumorigenesis in plants induced by species of Agrobacterium . Summa Phytopathologica ,v.33, n.1, p.9-15, 2007.Additional keywords: Tumors, Phytobacteria, Oncogeny, Transformation, Ti plasmid the pathogen transforms the plant by inserting a region of its ownplasmid into the genome of the latter, creating an specific ecologicalniche for itself. In this paper its is showed a historical brief on theevolution of knowledge about the genomic characteristics of the TiPlasmid, events and requirements needed for infection to take placeas well as it is discussed the transformation dynamics of the host bythe pathogen.


Five varieties of cormCichorium intybus L.were introduced and the comparison test was done in order to select the suitable variety for cultivation in the Jilin area.The results showed that the growth period and morphological characteristics of different varieties had significant differences,the yield of per unit area had very significant differences,and the resistance to disease,stress and insect of varieties were all strong.In which'red leaf Cichorium intybus' was the best,the second were'corm red Cichorium intybus','red Cichorium intybus' and'1044',could be cultivated in Jilin area,but the yield of'Queen'variety was low and not suitable for cultivation in Jilin area.


The behaviours of the microstructure coarsening of the Alnico8 thermomagnetically treatedat 800 C with time were investigated by means of transmission electron mocroscopy (TEM) and small angleX-ray scattering (SAXS) technology. The results indicated that, the alloy was decomposed in Fe-Co richphases, and Ni-Al rich phases in which the Ni-Al rich phase is ordered. The microstructure was coarsenedrapidly in a short time at the earlier stage of the treatment. And then with increasing the heating time,the microstructure is further refined and homogenized due to the decomposition of the larger Fe-Co richparticles in smaller ones. This is attributed to the large elastic distortion energy introduced during themicrostructure coarsening. It is the first time that the phenomenon called stability bifurcation is observedin Alnico8 with the complex chemical composition. Meanwhile, the aspect ratio of the rod-like Fe-Co richparticles increases with increasing the heating time. In addition, the Alnico8 treated for 10 min has the optimum magnetic properties.


Ray craters are impact craters surrounded by radial rays or ejecta patterns (both bright and dark) and prominent on Ganymede, the biggest satellite of Jupiter. Bright ray craters are recognized to be the youngest features on Ganymede [1], and represent the most recent impact cratering [2]. Also, being susceptible to destruction by various processes [1-3], bright ray craters may inform on the most recent geologic processes on Ganymede.


The Cherenkov Telescope Array (CTA) will be the largest ground-based observatory operating in the very-high-energy gamma-ray (20 GeV - 300 TeV) range. It will be based on more than one hundred telescopes, located at two sites (northern and southern hemispheres). The energy coverage, in the southern CTA array, will extend up to hundreds of TeV thanks to 70 small size telescopes (SST), with primary mirrors of about 4 meters in diameter and large field of view of the order of 9 degrees. It is proposed that one of the first sets of precursors for the CTA SSTs array will be represented by nine ASTRI telescopes. Their prototype, named ASTRI SST-2M, is installed in Italy. It is currently completing the overall commissioning before entering the science verification phase that will performed observing bright TeV sources as Crab Nebula, Mrk421 and Mrk 501 cross-checking the prototype performance with the Monte Carlo predictions. ASTRI telescopes are characterized by a dual-mirror optical design based on the Schwarzschild- Couder (SC) configuration. The focal-plane camera is curved in order to fit the ideal prescription for the SC design and the sensors are small size silicon photomultipliers read-out by a fast front-end electronics. The telescope prototype installed in Italy, has been developed by the Italian National Institute for Astrophysics, INAF, following an end-to-end approach that comprises all aspects from the design, construction and implementation of the entire hardware and software system to the final scientific products. All parts of the system have been designed to comply with the CTA requirements. A collaborative effort, addressed to the implementation of the first ASTRI telescopes for the CTA southern site, is now on-going led by INAF with the Universidade de Sao Paulo (Brazil), the North-West University (South Africa) and the Italian National Institute for Nuclear Physics.


Decision tree is one of heated fields in data mning in recent years,and it is a widely-used solution for classification problems. But the design of the optimal decision tree has been proved to be NP-hard. This paper first introduces the main thoughts of algorithm of ID3, then discusses some difficult problems of selecting value on division in decision tree,and puts forward an algorithm to improve the gain of information, and makes a contrast to ID3 by experiments. Results demonstrated this algorithm outdoes the others in the size of decision tree and classification accuracy.


Decontamination and Decommissioning (D important requirement of the U.S. Department of Energy''s Environmental Restoration and Waste Management (ERWM) program. Means need to be devised to minimize radiation exposure to humans involved in the D research presented in this paper describes a human-machine system which can be employed for performing radiation scan and pipe cutting operations in a typical D Advanced Servomanipulator (ASM) from the Oak Ridge National Laboratory (ORNL), we have designed a hybrid telerobotic pipe-cutting module. The module, when fully integrated, will allow users of the ASM to exploit the original functionality of the telerobot when our pipe cutting system is not in use. Comprising the pipe-cutting system are interactive three- dimensional object localization, graphical task modeler, arm control, human-machine interface, radiation sensor, and cut-tool sub-systems. Only the task modeler and interactive object localization modules are discussed in this paper. The goal of these modules is to interactively localize an object, usually a pipe, and display it in a three-dimensional rendering of the work space. Through interaction with these modules, the supervisor coordinates a task- specific sequence of actions that the lower-level sub-systems will perform.


Quantum Stochastic Calculus can be used as a means by which randomness can be introduced to observables acting on a Hilbert space. In this article we show how the mechanisms of Quantum Stochastic Calculus can be used to extend the classical Black-Scholes framework by incorporating a breakdown in the liquidity of a traded asset. This is captured via the widening of the bid offer spread, and the impact on the nature of the resulting probability distribution is modelled in this work.


ABSTRACT This study is an examination of an'attempt within the Adult Basic Education Department at College of the Mainland to reduce the anticipatory test fear in normal adult students preparing for the General Educational Development (GED) Test. The experiment covered a time span of 16 weeks and made-application of systematic desensitization, a therapeutic technique proper to the writings and practice of Dr. Joseph Wolpe. There is no vindication, from the pre-post testing of the cantrol group, that participation in a GED preparation class or the application of the systematic desensitization technique as applied in this experiment increases or decreases either basal trait anxiety or specific academic performance anxiety.. (Author/RC)


The present study examined the existence of unrealistic expectations in abusive parents. It was hypothesized that abusive parents would have higher expectations of their children's social-emotional and self-help skills than nonabusive parents. It was also hypothesized that abusive parents would have higher expectations of their children's social-emotional skills than nonabusive parents when both groups compared their children to average children. Abusive and nonabusive parents were administered the Social Competence Scales of the Child Behavior Checklist and the Daily Living Skills domain of the Vineland Adaptive Behavior Scales. The results contradict previous studies in this area and raise questions about present conceptualizations of expectations in abusive parents and the importance of this factor in child abuse.


We perform a temporal and spectral analysis of simulated and experimental photoplethysmographic signals. We obtain technical requirements for an advanced photoplethysmographic imaging system able to add photoplethysmographic waveform and oximetry maps to the conventional measurements. The imaging system is centered on measuring the pulsatile signals produced by diffuse reflectance on the inner layers of the skin. We consider controlled illumination conditions for the system, with visible and near infrared components. This work comprises backscattering evaluation, waveform analysis and spectral dependence of photoplethysmographic signal. We determine the resolution requirement for the system by evaluating the amplitude of the backscattered signal using Monte Carlo simulations. We determine the bandwidth limit for the signal acquisition by Fourier analysis from a set of plethysmographic waveforms. Finally, the spectral dependence of the system is obtained from experimental results. We establish the requirements for the photoplethysmographic imaging system, including the source, subject and detector conditions.


Control Mechanisms in International Human Rights Treaties: The Moderation Effect by Katarína Sipulova, Hubert Smekal And Jozef Janovsky [Katarína Šipulová is a student in an MSt in Socio-Legal Research, University of Oxford and a PhD candidate at the Faculty of Social Studies, Masaryk University. Hubert Smekal is an Assistant Professor at Faculty of Social Studies, Masaryk University; and Jozef Janovský holds an MSc in Applied Statistics, University of Oxford, having previously studied politics and applied mathematics at Masaryk University. This contribution comes from research under a project entitled "International Human Rights Obligations of the Czech Republic: Trends, Practice, Causes and Consequences," GA13-27956S, supported by the Czech Science Foundation GAČR.] The study finds that the strength of a human-rights treaty's control mechanism moderates the effect of the political regime on how states commit to HR treaties. Empirical test of the "moderation effect hypothesis" showed that the overall speed of the commitment process of communist Czechoslovakia and newer democratic regimes (CR and SR) was quite similar. However, while communist Czechoslovakia preferred commitments to treaties with weak control mechanisms, the transitioning CSFR and its democratic successors were more prone to ratify treaties with a strong control mechanism.


This study investigates the return lead–lag and volatility transmission between dry bulk shipping and container shipping freight markets over the period before, during and after the 2008 financial tsunami. Both cointegration analysis and the Granger causality test are applied to explore the lead–lag relationship between the Baltic dry index (BDI) and the China containerized freight index (CCFI). Besides, in the study we employed GARCH–BEKK model, which allows for transmission in freight volatility. On the whole, the empirical results show that the BDI reflects the economic climate earlier than the CCFI during the financial tsunami, whereas the CCFI leads the BDI after the financial tsunami. The price formation hypothesis could well explain the relationship. Moreover, volatility spillovers are found in most subperiods. The dynamics of the conditional volatilities differ, but causality links in the variance are found to be strong and bidirectional in normal periods, and unidirectional during the financial tsunami. Therefore, the occurrence of the financial tsunami could be regarded as an interference factor.


In Roger Howe's 1989 paper [5], Howe introduces the notion of a dual pair of Lie subalgebras – a pair (g1, g2) of reductive Lie subalgebras of a Lie algebra g such that g1 and g2 are each other's centralizers in g. This notion has a natural analog for algebraic groups; namely, a dual pair of subgroups is a pair (G1, G2) of reductive subgroups of an algebraic group G such that G1 and G2 are each other's centralizers in G. This paper presents substantial progress towards classifying the dual pairs of the complex classical groups (GL(n,C), SL(n,C), Sp(2n,C), O(n,C), and SO(n,C)) and their projective counterparts (PGL(n,C), PSp(2n,C), PO(n,C), PSO(n,C)). The classification of dual pairs in Sp(2n,C) already exists in the literature (see [6, Chapter 2]) and follows easily from Howe's analysis in [5]; the classifications of dual pairs in GL(n,C) and O(n,C) are also likely known, but an explicit treatment is lacking. In this paper, we provide a straightforward presentation of the classifications of dual pairs in GL(n,C), Sp(2n,C), and O(n,C) using basic techniques from representation theory. Additionally, we classify the dual pairs in SL(n,C) and SO(n,C), and present partial progress towards classifying the dual pairs in PGL(n,C) and PSp(2n,C).


Rapid and high-resolution histological imaging with minimal tissue preparation has long been a challenging and yet captivating medical pursue. Here, we propose a promising and transformative histological imaging method, termed computational high-throughput autofluorescence microscopy by pattern illumination (CHAMP). With the assistance of computational microscopy, CHAMP enables high-throughput and label-free imaging of thick and unprocessed tissues with large surface irregularity at an acquisition speed of 10 mm2/10 seconds with 1.1-µm lateral resolution. Moreover, the CHAMP image can be transformed into a virtually stained histological image (Deep-CHAMP) through unsupervised learning within 15 seconds, where significant cellular features are quantitatively extracted with high accuracy. The versatility of CHAMP is experimentally demonstrated using mouse brain/kidney tissues prepared with various clinical protocols, which enables a rapid and accurate intraoperative/postoperative pathological examination without tissue processing or staining, demonstrating its great potential as an assistive imaging platform for surgeons and pathologists to provide optimal adjuvant treatment.


compare enzyme activity measurements for the solid-associated microorganisms (SAM) made at pH 6.5 with those made at actual rumen pH in relation with the diet and time. Four cows were restricted- fed once a day at the level of 7 kg DM/d and received 3 diets: 100% cocksfoot hay, (diet H), 65% hay and 35% pelleted ground barley (diet HB) and diet HB with a continuous intraruminal infusion of bicarbonate salts (diet HBB). These diets were chosen for their pronounced differ- ences in the diurnal variations in rumen pH. SAM enzymes were extracted by sonication under anaerobic conditions from rumen contents col-lected 1 h before feeding, and 2 and 5 h after feeding on 2 consecutive days. Polysaccharidase and glycosidase activities were determined at pH 5.5, 6.5 and 7.5 by measuring the amount of re- ducing sugars or p-nitrophenol released from appropriate substrates. The results were anal- ysed by a split-plot analysis of variance. Gly-cosidases activities in the SAM decreased (P < 0:001 ) when the pH increased. A specific activity of 20.1, 15.3, and 12.3 nmol p-nitrophenol released/mg protein/min for the fi-D-glucosidase was measured at pH 5.5, 6.5 and 7.5, respec-tively. A similar pH effect was observed for polysaccharidase activities, but the variations were not significant (P > 0.05) for xylanase which had a specific activity of 180, 176 and 136 nmol reduced sugars released/mg protein/min at pH 5.5, 6.5 and 7.5, respectively. Nevertheless, variations in the enzyme activity of the SAM with diet and sampling time were similar (P > 0.05) for measurements made at pH 6.5 and at actual rumen pH. Thus, measurements of enzyme activity realized at pH 6.5 remain valid irrespective of ruminal physico-chemical conditions at sampling time. Suspensions of about 2 x 1 OS Polyplastron multivesiculatum were prepared from the rumen con- tents of sheep harbouring this single ciliate genus. Each suspension was incubated for 24 h in anaer- obic conditions with 40 ml of a buffer solution and chloramphenicol (50 μgml-1) in a fermentor. The formation of the end products of the digestion and fermentation of the celluloses tested was measured by comparison it with control fermentors that received no substrate (2 fermentors per series) and fermentors to which 80 mg of cellulose were added (4 fermentors with soluble celluloses and 6 fermentors with crystalline celluloses per series). Incubations were performed during 4 sep- arate series of measurements. P multivesiculatum did not ferment the soluble celluloses but had an effect on the degradation and fermentation of the 3 different crystalline cel- luloses tested (8-12 mg fermented in each fer-mentor in 24 h). The total production of volatile fatty acids (VFA) was 0.50 ymol/1 000 ciliates, made up of 72% acetate and 28%


To study the anti-inflammatory effect of ethanolic extract of Moringa oleifera leaves using the technique of Carrageenan induced hind paw edema in albino rats. It is a randomized control study. Albino rats of the Wistar strain between weight 100-150 g were used. The animals were starved overnight with water being provided ad libitum. The Ethanolic extract of Moringa Oleifera (EMO), and the standard drug were administered by oral route. One hour later the rats were challenged with the subcutaneous injection of 0.1 ml of 1% solution of carrageenan on the plantar surface of the left hind paw. The paw was marked with ink at the level of lateral malleolus and immersed in the water chamber of the digital plethysmometer for measuring paw volume. The paw volume was measured before and after carrageenan injection at 1,2,3,4,6 &24 hrs. The efficacy of the drug was tested on its ability to inhibit paw edema. The ethanolic leaf extract of Moringa oleifera showed significant (p<0.05) reduction of paw volume edema at 100 ,200 ,400 mg/kg compared with the control group. The percentage inhibition of paw edema was maximum at 4hrs with EMO 400 mg/kg of 63%


This paper presents the theory and method to realize SSB modulation by using DSP, and (analyzes) the key techniques. An actual SSB digital modulation system with TI TMS320 series is designed. Compared with the analogue modulation, the performance of the digital modulation system is more stable and easily realizable with more simple circuit.


This paper addresses the problem of maximum pseudo-likelihood estimation of the non-homogeneous Potts image model parameters using higher-order non-causal neighborhood systems in a computationally efficient way. The motivation is the development of a new methodology for contextual classification that uses combination of sub-optimal MRF algorithms for multispectral image classification, which requires accurate parameters estimation. Our objective is to make multispectral image contextual classification fully operational without human intervention. The results show that the method is consistent with real data and in the presence of random noise.


We investigate the effects of a temperature-dependent shear viscosity over entropy density ratio η/s, with a minimum near the phase transition, on the elliptic flow of hadrons in ultrarelativistic heavy-ion collisions at the RHIC and the LHC. We find that the suppression of the elliptic flow in Au+Au collisions at the RHIC is dominated by the viscosity in hadronic matter and in the phase transition region, but insensitive to the viscosity of the quark–gluon plasma (QGP). However, at the highest LHC energy, the elliptic flow becomes sensitive to the shear viscosity of the QGP and insensitive to the hadronic viscosity.


In a base solution containing NaOAc-HCl buffer (pH 1.5), potassium iodide and gelatin, an oscillopolarographic wave of Pb~(2+) was observed at potential around -0.55V (vs. SCE). The peak heights of the wave (i_p) kept a linear relationship with the concentrations of lead in the range 0.01~0.80μg·ml~(-1). This method has been applied to the rapid and direct determination of traces of lead in agastache rugosa capsules. RSD′s (n=6) obtained were less than 3.6%, and recoveries in the range of 92% to 104% were found


In response to falling rates of bulk billing, in April 2003 the Australian Government proposed changes to the way that general practitioners (GPs) are reimbursed. It claimed that the General Practice Access Scheme (GPAS) would benefit all Australians by providing more affordable access to GP services and improved access to free GP consultations for concession cardholders. This article examines the likely impacts of the GPAS, focusing on the proposed changes to bulk billing and payments to GPs. It examines the current spatial distribution of bulk billing and discusses how the package changes the incentives for GPs to charge patients and likely impacts on GP income, patient copayments and bulk billing rates.


The interactions of methyl and propyl p-hydroxybenzoate with polyethylene glycol (PEG) 4000 were investigated by means of an ultrafiltration technique. The results show that the interaction is a weak and nonspecific process of large binding capacity, and is a type of partitioning phenomenon between the macromolecule and the aqueous phase. The characteristics of this interaction are quite similar to those of the binding of p-hydroxybenzoates with the polyoxyethylene region of polyoxyethylene dodecyl ether (PDE) micelles. A solubility study of p-hydroxybenzoates in aqueous solutions of PEG-400 was also performed. Assuming that the increase in solubility of the preservatives in the presence of PEG was due to the interaction with PEG, the ratio of bound preservative concentration to PEG concentration was calculated. The ratio increased as the concentration of PEG in the solvent increased, and this was thought to be due in part to a dehydrating effect. A comparison of solubility data with the binding parameters of p-hydroxybenzoates for the secondary binding sites of PDE micelles provided information concerning the micellar hydration. The amount of water trapped by nonionic surfactant micelles was estimated and the values thus obtained were consistent with those reported elsewhere.


Selection Sort which proceeds on linear list is a kind of Sionple inner sort algorithms.Computer workers always research and discuss the realization as well as improvement on Selection sort Algorithon of link list.In this article we discuss the algorithm and realization proceeded on single-link list and static-link list.Finally we analyze the complexity of time and space of the.


We studied electronic states of borophene in a crystal of rare-earth aluminum/chromium boride and the hydrogenated sheet, borophane, successfully prepared by ion exchange and liquid exfoliation of the crystal. The layer has a boron network with five-membered and seven-membered rings. Electronic structures of all the boron-derived layers are found to be gapless by soft x-ray absorption and emission spectroscopy measurements at the B K-shell absorption edge and density functional theory calculations. The present results support the existence of a Dirac nodal loop at the Fermi level in the borophane layer with five- and seven-membered rings, predicted recently by topological calculations.


It is important to recognize the impact of programming languages on the production of language because they ultimately affect the production of language digitally and will demonstrate a lasting effect on the process of writing.


Adults who have limited English skills, usually immigrants or refugees, often face poor labor market prospects. The number of such individuals in the U.S. workforce has grown dramatically over the past decade—accounting for nearly half of all workforce growth—yet the workforce development implications of this growth have received scant attention. Current resources for language and job training services are dwarfed by the need. Moreover, few programs focus on providing the nexus of language, cultural, and specific job skills that are key to helping low-income adults with limited English skills increase their wages and economic status—and to helping our nation's economy grow.


Leaf anatomical characteristics of eight species plants on Heimahe Grassland are compared and analyzed using wax-slides.Results showed that leaf structure of all species is similar,composed of epidermis,mesophyll and leaf vein.The leaf belongs to two types: bifacial leaf and Isobilateral leaf.Their common characteristic is that palisade tissue has multilayered and well-developed.The ratio of palisade tissue and spongy tissue is high.The cell is arranged loosely with well-developed aerenchyma.Leaf vein has well-developed and separated by small space.Differences among leaf anatomical structure are the ranges of variation among thickness of leaf and mesophyll,intercellular space.The range of the thickness of spongy tissue variation is the biggest followed by intercellular spaces and the ratio of palisade and spongy.All leaf anatomical structures of eight species show distinctive characteristics for both mesophyte and xerophytes,and even hygrophyte.Results show that there may be distinctive manners of plant adaptations to various environments,but that all plants adapt to hypoxia,low temperatures,and intense radiation environments.


Formal education in the Primary School (the PRIMARY SCHOOL), the stu- dent Could blind study of the map to know information about available Provinces as well as cities in the Javanese island. To facilitate studied him, that is with use of com- puter technology. One of Them by using CD Interactive Learning. That on the basis of making the CD writer was interested be entitled the Interactive Learning Blind Map of the Javanese Island by using Macromedia Flash. This inter- active CD was one of learning where the student was asked for to ll in the name of the city That has been marked with the keyboard used. The Library use and Actionscript in the production of this program were the resource per- sons were the resource persons That facilities provided by Macromedia Flash to facilitate the production and organi- zation. That movie le was needed in this interactive pro- duction of the CD


A method of NIRS for the determination of contents of alcohol and moisture in fuel alcohol made from cassava was proposed,in order to determine the quality of the fuel alcohol.Based on the spectral data of samples and by the application of revised partial least square method,the calibration models relating the contents of alcohol and moisture to the respective NIR spectra were established.It was found that the results obtained by the present method were in consistency with those obtained by chemical method.The following parameters were obtained: values of square errors of Cross-Validation and correlation coefficient of the calibration model were 0.110 2 and 0.960 5 for alcohol,0.014 3 and 0.975 9 for moisture.


1. A method of heating the molded part (2) for subsequent tempering under pressure, wherein the shaped part (2) is first heated to a predetermined temperature, followed by configured to control independently the heating elements (7) of the field (10) of the heating elements is heated in selected areas to a higher temperature, characterized in that the shaped part (2) during its transport through the field (10) of the heating elements is heated by the heating elements (7) arranged relative to the direction NIJ (3) transportation of longitudinal and transverse rows (8, 9) and configured to control, at least in groups, with different power nagreva.2. A method according to claim 1, characterized in that the shaped part (2) in the direction of strip-cooled (3) by means of respective conveying longitudinal rows (8) of heating elements (7) arranged to control the choice of the cooling device (15) .3. Continuous furnace (1) for zone heating preheated to a predetermined temperature of the molded part (2) to a higher temperature, comprising passing through its body (14) conveyor (11) for the molded part (2) and a corresponding conveyor (11), the field (10) heating elements of the individual, adapted to control independently the heating elements (7), characterized in that arranged relative to the direction (3) of movement of the conveyor (11) with longitudinal and transverse rows (8, 9), heating elements (7) made with to control, at least in groups in longitudinal and transverse directions with different power nagreva.4. oven


In this paper we wish to call attention to some experimental facts which may give a clue to the real nature of beryllium, an element which since the beginning of this century has been the enigma of inorganic chemistry.


Background: Iron deficiency is the most common cause of anemia during pregnancy. Red dragon fruit is assumed having much iron to increase hemoglobin and erythrocyte level. Objective: This study aims to examine the effect of dragon fruit juice on levels of hemoglobin and erythrocytes.  Methods: This was a quasi-experimental research with non-equivalent control group design. There were 34 respondents recruited in this study using consecutive sampling. The samples were divided into intervention group (17 respondents) and control group (17 respondents). Data were analyzed using independent t-test and paired t-test. Results: There was a statistically significant effect of red dragon fruit juice Hb level on the 7 th day of intervention with p-value 0.037 ( 0.05). This study also revealed that there was a statistically significant effect of red dragon fruit juice on pregnant women's erythrocyte level on the 7 th day with p-value 0.025 ( 0.05).   Conclusion: There was a statistically significant effect of red dragon fruit juice on hemoglobin and erythrocyte levels. This study provides the insight of knowledge that the red dragon fruit juice can be an alternative treatment to deal with anemia among pregnant women.


Objective to explore clinical application value of mycoplasma pneumonia antibody detetion with indirect haemagglutination assay in children respiratory passage infection. Methods 50 cases with mycoplasma pneumonia infection by clinical definite and 30 cases with non-respiratory infection; to contrast the infection state of mycoplasma pneumonia in 535 cases respiratory infection in children. Results the sensitivity was 92.6% and specificity was 93.3% in indirect haemagglutination assay in 50 cases with mycoplasma pneumonia infection by clinical definite; the masculine rate was 22.8% in 535 cases respiratory infection; the masculine rate in group of under 3 years was 11.4%, between 3 and 6 years was 29.3%, 6 and 12 years was 17.9%. Conclusion mycoplasma pneumonia antibody detection with indirect haemagglutination assay could be applied clinically because of the simplicity of the operation and cheap price.


To understand the barriers to vasectomy in Honduras, an operations research project is being conducted. 2 separate research activities composed the initial phase of the project. The 1st activity was a series of focus-group discussions to determine male attitudes and beliefs about vasectomy. The 2nd activity was a knowledge, attitude, and practice survey which studied a larger and more representative sample of the population. In the groups, the men frequently said that they should be more responsible for family planning. Although a few men could explain vasectomy, most of them knew little about the procedure. Preliminary findings from the survey indicate that more than 2/3 of the sample had never heard of vasectomy. Misconceptions regarding vasectomy were widespread. More than 80% believed that the woman should be sterilized. Only 5% believed that the man should be sterilized. 58% agreed that information regarding vasectomy should be provided in their communities. These preliminary results clearly demonstrate a need for a widespread educational campaign concerning the nature of vasectomy and its benefits and risks.


RESPECT THE INVENTION A METHOD AND DEVICE FOR PERFORMING MEASURES IN RESPONSE OUET SERVING WELL STRONGLY INCLINED RELATIVE TO THE VERTICAL OR HORIZONTAL WITH A SET OF INSTRUMENTS PLACE TO LOWER END OF 'COLUMN RIGID. RESPECT THE INVENTION ALSO A METHOD FOR PERFORMING SEISMIC PROFILES THE METHOD ACCORDING TO THE INVENTION IS ESPECIALLY CHARACTERIZED IN THAT:. PLACED ON OR KEEPS ON SUCH POSITIONS SET 2 IN EXTENSION COLUMN THE LOWER END OF THAT COLUMN SAID SET 2 BEING IN A FIRST POSITION WITH RESPECT TO THAT END; ON INTRODUCED INTO THE WELL SAID SET 1 2 AND THAT LOWER PART OF THAT COLUMN; ON ADVANCES IN WELL SAID SET 1 PUSH ON THAT GRADUALLY END OF THAT UNTIL SUCH COLUMN SET REACHES AN ESSENTIALLY DESIRED POSITION; RELEASED ON AND ON SUCH CLEAR ALL OF ITS FIRST POSITION AND ON THE LEADS IN SECOND POSITION IN WHICH THE SAME IS BASED ON A WALL AND WELL IT IS MECHANICALLY DECOUPLE OF THAT COLUMN, THE LINK BETWEEN SAID THAT TOGETHER AND COLUMN BEING MADE BY A LINE FLEXIBLE HOSE AND MADE ON MEASURE OUET INTERVENTION. DEVICE ENABLES THE IMPLEMENTATION OF THE METHOD. SEISMIC METHOD IS ESPECIALLY CHARACTERIZED IN THAT YOU MADE THE MEASURES IN A SUBSTANTIALLY HORIZONTAL DRAIN WHERE A SEISMIC SOURCE IS PLACED AT THE SURFACE IN ACTION. APPLY THE INVENTION INCLUDING MEASURES OUET ACTIONS THAT WE MADE IN DRILLING ON THE GROUND.


BACKGROUND:Mesenchymal stem cells(MSCs) have the potential of multilineage differentiation. Some researchers put them into tissue-regeneration or diseases treatment. There are many studies about MSCs derived from bone marrow,umbilical cord of rat or mouse. However,little is known about MSCs derived from rat placenta. OBJECTIVE:To establish a method to isolate MSCs from rat placenta and to observe its biological characteristics in vitro. METHODS:Rat placental MSCs(r-pl-MSCs) were separated and obtained by collagenase-digested method. Morphology of r-pl-MSCs was daily observed with inverted microscope. Growth kinetics was measured with MTT assay and growth curve was drawn. Their surface antigens and cell cycle were detected by flow cytometer. Adipogenic differentiation and osteogenic differentiation were tested by immunohistochemistry. RESULTS AND CONCLUSION:The primary cultured cells adhered after 8 hours and formed clone within 24 hours. The size and morphology of the 4th generation cells were almost same;most cells were fusiform-shaped. Cell cycle measure showed the proportion of cells in G0/G1 phase,S phase,G2 phase was respectively 83.76%,8.01%,8.23%. Immunophenotype analysis showed that the cells expressed CD29 and CD90,but no CD45. Placenta-derived MSCs have potentials of adipogenic and osteogenic differentiation in special culture condition in vitro.


Aim of this paper is to represents the design and control strategy of UPQC to get the highest benefit in terms of maximum power transfer capability and system stability. The UPQC design and controlling is shown using current source topology. FACTS devices are very effective and capable of increasing the power transfer capability of a line, as thermal limits permit, while maintaining the same degree of stability. With the improvements in current and voltage handling capabilities of the power electronic devices that have allowed for the development of Flexible AC Transmission System (FACTS), the possibility has arisen in using different types of controllers for efficient shunt and series compensation In series compensation, the FACTS Sis connected in series with the power system. It works as a controllable voltage source. Shunt compensation, power system is connected in shunt with FACTS. It works as a controllable current source. The rating of a shunt FACT device is selected in such a way so as to control the voltage equal to sending end voltage at the bus of the shunt FACT device. In this paper modelling and simulation has been done for voltage balancing of the system.


There is no denying that policy actors matter in driving policy change. Most of the policy process frameworks argued for the centrality of policy actors but have similarly contended that the occurrence of policy change is contingent upon the dynamic interaction of policy actors, organizations and institutions. But the roles played by the actors in the policy process has been typically framed in terms of the technician-politician dichotomy. The burgeoning literature on the increasing complexity of policy work, however, shows a spectrum of roles instead of a binary distinction. Policy work is comprised of functions within and outside the government that transcend the political-analytical distinction. Despite this recognition, very limited attention has been given towards systematically and comprehensively measuring the set of skills and resources necessary for policy actors to perform this various functions. This paper discusses the development of instrument to address this gap in public policy literature. It builds on the framework of policy capacity developed by Wu, Ramesh and Howlett (2015) by integrating three separately assessed dimensions of policy capacity (analytical, managerial and political) into one measurement instrument. In doing so, we hope to measure not only the levels of individual policy capacity but also the dynamic interactions of the policy actors with resources at the levels of the organization and policy system.


MicroRNAs (miRNA) are small, non‐coding RNAs that play a critical role in post‐transcriptional gene regulation by acting as a guide for directing the repressor protein Argonaute 2 (Ago2) and its RNA‐induced silencing complex (RISC) to mRNA targets. Recently, we reported on the dynamic movements and localizations of individual miRNAs in living cells, thus demonstrating the feasibility and potential of using single molecule analysis to study non‐coding RNAs in the cellular environment. Our goal is to now extend these studies to the Ago2 protein, the central effecter of the miRNA pathway. Rudell et al (2011) recently found that mutation of the conserved tyrosine Y529 located in the 5′‐end‐binding pocket of Ago2 to a negatively charged glutamate mimics phosphorylation by an as‐yet‐unknown kinase and inhibits small RNA binding. We plan to incorporate this mutation using site‐directed mutagenesis into a plasmid encoding a human Ago2‐EGFP fusion. Using fluorescence microscopy, we will then monitor and compare the localizations and diffusive properties of EGFP‐Ago2 Y529E to its wild‐type counterpart in HeLa cell lines under transient expression. Since EGFP‐Ago2 Y529E is incapable of binding miRNA, it will enable us to distinguish the diffusive motions of miRNA‐loaded RISC from unloaded‐RISC, and to characterize and potentially quantify miRNA loading, a critical step in the miRNA pathway.


The Directors of the three institutes, CRM, Fields and PIMS are pleased to announce that Martin Barlow from UBC is the recipient of the 2009 CRM – Fields – PIMS Prize. Martin Barlow is a leading figure in probability and the leading international expert in diffusion on fractals and other disordered media. In addition, the impact of his work has been important in such diverse fields as partial differential equations, including major progress on the De Giorgi conjecture, stochastic differential equations, the mathematical finance of electricity pricing, filtration enlargement and branching measure diffusions.


Low Voltage Direct Current (LVDC) Photovoltaic (PV) systems are considered suitable solutions for increasing the capacity of existing LV networks. They provide a good power quality, renewable energy source compatibility, and simple integration with batteries. This paper compares the proposed LVDC supply concept with existing traditional PV systems regarding energy efficiency. The proposed LVDC Photovoltaic System was realized. The results obtained from this study revealed that using the LVDC system supply concept, instead of Low Voltage Alternative Current (LVAC) ones, is very interesting if the PV-generated electricity is used locally during day hours. To achieve a high PV system efficiency, the PV power installed in the houses should be accurately sized regarding the consumed energy. The shorted path taken by the PV-generated power to feed load during daytime is the main advantage of the proposed LVDC architecture.


The advent of sequencing technologies and efforts in sequencing and analysis of polymorphic regions in various viruses, bacteria, and higher organisms, including humans, has led to a wealth of genetic information (1)(2). This information is used to relate genetic information to phenotypic effects, which is used to provide better tools in drug development and a better understanding of the biologic pathways involved in various rare as well as common diseases in humans. A tool in this type of analysis is parallel testing on the basis of microarrays. These arrays, sometimes referred to as "DNA-chips", usually consist of a flat surface with capture probes at specific positions (spots) directed toward the various targets that may be present in the sample.

The use of microarrays for genomic-based screening and the search for new genes has been well documented by scientific groups using systems (e.g., from Affymetrix and Sequenom) that have integrated many novel, microscale technologic developments (3)(4). The ability to either deposit directly, or synthesize in situ, hundreds or thousands of oligonucleotides on glass surfaces in subnanoliter volumes at high density allows for high-throughput simultaneous detection.

These first-generation microarrays, characterized by passive hybridization between targets and probes, are typically performed on planar surfaces. The fundamental problem caused by the concept of working on a basic two-dimensional surface has led many research groups to develop second-generation microarrays that seek to enhance the performance of this platform. The aim is more toward low costs, reproducibility of hybridization signals, and speed. …