Olga Shishkina, Max Planck Institute for Dynamics and Self-Organization, Goettingen, Germany (MPIDS), and Robert E. Ecke, Center for Nonlinear Studies, Los Alamos National Laboratory, New Mexico, USA, Eberhard Bodenschatz, Marcel Wedi, Stephan Weiss, Xuan Zhang, Lukas Zwirner, MPIDS ——Experiments and simulations reveal that in rapidly rotating containers, the classical large-scale circulation (LSC) in turbulent Rayleigh-Benard convection (RBC) is replaced by a boundary zonal flow (BZF) which is located near the vertical side wall, where a prograde fluid motion and retrograde thermal traveling wave are observed (Zhang et. al. PRL 124 (2020) 084505). Both turbulent convective superstructures (LSC and BZF) play key roles in the global heat transport in the system. In this talk, we will analyze the robustness of the BZF in rapidly rotating RBC and discuss, what determines the size of the LSC rolls in classical RBC in slender (Zwirner et. al. PRL 125 (2020) 054502) and wide containers (Wang et. al. PRL (2020), in print).


A Master of Science thesis in Chemical Engineering by Mohamad Mahmoud entitled, "The Effect of Ultrasound on the Drug Delivery of RGD-Targeted Liposomes", submitted in May 2018. Thesis advisor is Dr. Ghaleb Husseini. Soft and hard copy available.


ABSTRACT Although social support has been linked to improvement in health behaviors, little is known about social support among those most affected by the AIDS epidemic: low-income, young adult, African-American women and their children. Since the age and gender of informal support providers have been shown to influence the types and degrees of social support one receives, this paper examines differences in types and degrees of social support, by age and gender of support persons, received by self-identified African-American female caretakers (n= 197) attending an HIV prevention program. Age of support person was positively associated to overall perceived social and emotional support, as well as to the support person's willingness to help respondents. Adult persons appeared to provide more overall social support to respondents, and to be more eager to help, than did younger persons, even though adult supports made fewer personal contacts. Respondents received significantly more overall social and emotional support from females than from males. Implications for family-based HIV prevention are discussed below.


Objective To investigate the anesthetic effect of sumianxin in combination with pentobarbital in dog experiments.Methods Sixty healthy dogs were included in the present study,males and females together.The anesthetics were administered intramuscularly.Results The anethesia induction time was 6 minutes in average.The anesthesia time lasted at least 270 minutes.Although sumianxin anethesia revealed well response for sedation,analgesia,as well as muscular relaxation,the combined use of pentobarbital in a half of its recommended dosage made a better anesthetization showing prolonged and stable anesthesia,with quick and smooth resuscitation.Conclusion Sumianxin combined with pentobarbital anethesia appears to be a satisfactory method for dogs during prolonged operation.


To investigate antivirus affects of marine actinomycin X2 against Coxsackieviru(CVB3),we detected the expression and secretion of vascular cell adhesion molecule(VCAM-1) in CVB3-infected ECV304 cells,and studied the effects of marine actinomycin X2 on the expression of VCAM-1 in CVB3-infected ECV304 cells.By adopting MTT methods,we detected the inhibitory action of virus by using different concentrations of marine actinomycin X2 and study the efficacy of viral adsorption.Cytoplasmic RNA from ECV304 cells was extracted by the Trizol method and mRNA levels of VCAM-1 were assayed by reverse transcript-polymerase chain reaction(RT-PCR).Flow cytometer was used to detect ICAM-1 expression on the infected ECV304 in different time courses respectively.We found that marine actinomycin X2 could inhibit virus before absorption of CVB3 into the normal cells and the SI was 63.88.The normal ECV304 did not express VCAM-1 mRNA in all 54 hours,but in the infected ECV304 cells,the expression of VCAM-1 mRNA was increased in 6-54 hours among which the VCAM-1 mRNA reached a peak at 12 hours point post-infection.The infection of CVB3 increased VCAM-1 protein expression on the surface of ECV304 at 12-48 hours.In CVB3+X2 group,the expression of VCAM-1 mRNA was lower than that of CVB3 group at 12-54 hours(P0.05),and the expression of VCAM-1 protein was lower than that of CVB3 group(P0.05) at 12-24 hours.In conclusion,marine actinomycin X2 has anti-viral function,and has protective effects on the injured ECV304 exposed to CVB3.


the ABSTRACT Background: There is sparse research on Vitamin D levels in children and adolescents with autism and ADHD from India, hence the need for this study. Aims and objectives: To assess the profile of Serum Vitamin Levels from retrospective records of children and adolescents diagnosed with autism and ADHD. Methodology: This was a retrospective study of children and adolescents who were diagnosed with autism and ADHD and were attending the child and adolescent psychiatry outpatient clinic at the Department of Psychiatry, MGM Medical College and Hospital, Navi Mumbai over the past one year. The Records of Child and Adolescent Psychiatry Clinic were referred for the past 1 year for the demographic details and Diagnostic Profile of the sample. The Biochemistry Department Records were referred for the Serum Vitamin D levels of the children and adolescents with autism and ADHD. Results were tabulated in excel sheet and analysed. Institutional Ethics Clearance was obtained. Results: We found that 142 children and adolescents were diagnosed with Autism and ADHD over the past one year. Out of the 142, Serum Vitamin D level records were available for n=70. The sample size n=70 was analyzed further. The mean age was found to be 11.84 years and maximum (80%) were from urban areas. The sex profile of the sample comprised of 41.43% boys and 58.57% girls. As per the Psychiatric Diagnostic Profile, 40% had ADHD, 55.72% had Autism, while 4.28% had both Autism and ADHD. Serum Vitamin D Levels Profile of the entire sample were Normal Vitamin D levels (14.29%), Insufficient Vitamin D Levels (18.57%), Severe Vitamin D deficient levels (37.14%), and very Severe Vitamin D Deficient Levels were seen in 30% of the sample. Conclusion: Our study has further research and clinical Implications in this domain of Vitamin D deficiency and children and adolescents with autism and ADHD.


Microstructure and electrochemical characteristics of La0.7Ce0.3Ni3.75Mn0.35Al0.15Cu0.75–x(V0.81Fe0.19)x hydrogen storage alloys were investigated. XRD indicated that La0.7Ce0.3Ni3.75Mn0.35Al0.15Cu0.75–x(V0.81Fe0.19)x alloys consisted of a single phase with CaCu5-type structure, and the lattice parameter a and cell volume V increased with increasing x value. The maximum discharge capacity first increased from 319.0 (x=0) to 324.0 mAh/g (x=0.05), and then decreased to 307.0 mAh/g (x=0.20). The high-rate dischargeability at the discharge current density of 1200 mA/g first increased from 52.1% (x=0) to 59.1% (x=0.15), and then decreased to 55.4% (x=0.20). The hydrogen diffusion in the bulky alloy was responsible for the high-rate dischargeability. Cycling stability first increased with increasing x from 0 to 0.10 and then decreased when x increased to 0.20, which was resulted from the synthesized effect of the improvement of the pulverization resistance and the decrease of corrosion resistance.


The history of our world today cannot be constructed without reckoning with the frequency of armed conflicts in many parts of the globe. Armed conflicts and wars have unfortunately assumed an important part of human existence. This paper conc nonetheless had from earliest times become the scourge of humanity. Ranging from loss of lives and property, internal displacement of people, the flow of millions of refugees, to general destabilization o consequences of armed conflicts constitute veritable assault to human dignity. This paper critically examines the underlying philosophy and jurisprudence that relate to or empower and engender armed struggles. Far from recommending p war theory, and finds its principles as the desideratum to the untoward indignity meted to the human resource. rules of International framework.


Digital breast tomosynthesis (DBT) has been shown to decrease breast structural noise thus improving the detection of masses. However decreased detectability of microcalcifications was observed, and several studies have been performed to investigate the benefit of taking an additional central projection view after a DBT scan. Our study investigates the effect of variable angular dose distribution within a single DBT scan. Using a prototype DBT system with uniform angular dose distribution, several DBT scans (25 projection views over 40 degree angular range) were performed using different glandular doses. A subset of projection images was selected from each scan to form composite DBT scans (25 views each) with different angular dose distribution schemes (ADS). Two examples of ADS were: 1) seven central views with four times the dose of periphery; and 2) five central projections with six times the dose of periphery. The total dose for each ADS was the same as a reference scan with uniform dose distribution (1.5 mGy). They also had the same number of views and angular range, and were reconstructed using identical reconstruction filter settings. The detectability of calcifications, the 3D MTF and NPS of the system, and the ideal observer object detectability index for all cases were compared. The results showed that higher dose for the central views improve the detectability of calcifications. However magnitude of improvement depends on the reconstruction method and the size of the object.


AbstractThis paper is based on technical examination of the painted panels of the Santa Marina retable, c. 1490, attributed to a Castilian painter called the Master of Palanquinos. There are two distinct styles of underdrawing, painting and gilding, indicating that two different painters worked on the retable, at least from the underdrawing stage onwards. These findings are compared with documentary evidence which indicates that collaboration between independent masters was common in fifteenth-century Spain. The techniques of construction and painting are also described and comparisons made with contemporary documents, in particular the 1493 Cordoba ordinances which specify the technical standards to be expected of master painters.


An increasing proportion of the elderly population should be aware,  because the main manifestation of the aging process experienced by the elderly can reduce ability to work, and  the ability to perform the activity and social interaction with their environment. To overcome this problem, a group-based restorative care model is needed to increase the social interaction among elderly. This study aimed to obtain an overview of the effectiveness of the group-based restorative care model on the social interactions among elderly in nursing homes. The research design used a quasi-experimental with control group design with a sample size of 66 elderly who have been living in nursing home in the DKI Jakarta area. Data analysis used t-test and Mancova test. The results of the study found that there were differences in social interaction before and after the intervention in the intervention group, while in the control group there were no differences; there were differences in social interaction after the intervention between the intervention group and the control group; there was an effect of social support on social interaction. The recommendation is the group-based restorative care model can be used as a model for empowering the elderly in carrying out various activities in various health care settings in the community


Authors has proposed a new method to decrease high-frequency noise at specific frequency band with modification of switching transient slope. In this paper, new voltage feedback type VDS controller (gate driver) has proposed to realize modified switching transient to increase stability. In the step-down converter applied propose VDS controller, harmonics reduction effect is obtained about 10 dB in AM radio band. Then, output voltage and switching loss characteristics was measured on the step-down converter applied proposed method. It is verified that these characteristics are same to conventional converter. In addition, the proposed method was applied to H-bridge step-down converter for DC motor drive application. It is verified that MT-PWM is able to realize in H-bridge step-down converter without any major modification through simulations.


Mao Zedong critically inherited the traditional Chinese philosophy,but also enriched and developed it,and scientifically summarized its development direction.He carried forward the Chinese culture,so that the ancient Chinese culture conformed to the historical trend.Contemporary,philosophical thought of Mao Zedong era of bursting out with dazzling brilliance.In today's China to vigorously promote the socialist core value system,and vigorously promote socialist advanced culture,the era of great development and prosperity in the context of how to correctly deal with China's traditional culture,especially traditional Chinese philosophy has become an urgent problem to be solved.From this perspective,of,the attitude and method of Mao Zedong in inheriting and developing the traditional Chinese philosophy brought us new meaning and enlightenment.


The k-medilw problem is one of the classical problems in lo=tion theory and clustering. It has been well-studied for over the decades. Given a distance metric on n nodes, the task is to [lid the location of k median points (or facilities) so thlLt the sum of the distances frOID each node to its nearest median is minimized. We apply some recent techniques in improving tree dynamic programming to the case of unweighted and weighted k-mcdian problem on trees. The previous known best bound is 0(1..'11 ) by Tallir [1]. We show that improved complexity bounds for the problem llTC possible when k and h (the height of the tree) nrc asymptotically smaller than n. For the unweightcd cnse, we obtain the complexity bound of O(kn(h + logn)). In the particular CB.SC of TlUldom trees this implies O(kn 3/2 ). In the cnsc of balllJ1Ccd trees, we achieve O(k2 n log(n/k)). For the weighted cn.sc, we show that similili bounds are p055iblc if we allow a small error in the optimal objective value. Also, in the cnsc of balanced trcc." we aclJ1eve Illl O(npolylog(n» time algorithm for the weighted case, if we assume k to be a fixed constllJ1t. This is the fIrst known result wWch achieves better bounds than previously known O(k-n2 ) for many particular cases and promises to be sub-quadratic in n.


Lampung Province has the potential as a producer of mineral fertilizers. The availability of mineral and rock resources in the area has the potential to be processed into mineral fertilizers. Rocks and minerals have been shown to increase productivity and maintain fertility of agricultural land. Rocks and minerals such as zeolite, basalt, pumice, limestone, phosphate and pearlite, its availability in Lampung Province makes it possible to become an agro-mineral industry raw material. For this reason, there is a need for good cooperation between related agencies to create processing of rocks and minerals into effective, efficient mineral as fertilizers.


The Federal Trade Commission (FTC) has increased thresholds and penalties pertaining to the Hart-Scott-Rodino (HSR) pre-merger notification regime. The Commission also increased the thresholds…


This paper outlines the questionnaire content of the 1980 Census of Population, and provides a brief rationale for changes that have been made since the 1970 Census. In addition, coverage improvement plans that are new to the census operation are delineated.


Dr. Nelson reminded those present that some time previously the membersof the medicaland legal professionshad combinedand formed a society at whose meetingscombined medico-legalsubjectswere to be discussed. That society had not met for some time; but it had been thought that that evening's meeting would be a good opportunity to invite some membersof the legal profession to be presentand to take part in the discussion. Dr. Nelson then welcomed the membersof the Bar Associationand of the IncorporatedLaw Institute who had come to the meeting.


THEAPPLICATION OF GALLERY WALK MODEL AND KOKAMI MEDIA TO IMPROVE STUDENTS' ACHIEVEMENT IN BIOLOGY ON ELEVENTH GRADE STUDENTS IN SEKOLAH MENENGAH ATAS NEGERI 10 BOGORThis research is a Classroom Action Research (CAR) which aimed at to improve students' achievement in biology using gallery walk model and mystery cards box. The samples are 35 students of the eleventh grade IPA 2. This research was done in two cycles, with each cycles consist of two meetings. There are four stages for each cycles, they are planning, treatment, observation, and reflection. Evaluation is given at the end of every cycles using calibrated instrument. The evaluation result on the first cycle is 74,48 there are 24 students reach the maximum mastery criteria with KKM achievement percentage around 68,57% from 35 students, and on the second cycle the average score increased into 81,45 with KKM achievement percentage at 82,85%. It shows that the application of gallery walk learning model and Kokami media can improve students' achievement of the eleventh grade IPA 2 in biology subject in  SMAN 10 Bogor.


Background: Bi-columnar plating via combined anterior and posterior approaches is routinely applied treatment for complex acetabular fractures with noteworthy shortcomings. The goal of this study was to evaluate the effectiveness of the anterior plating with an ilioischial plate through the combined anterior approach for complex acetabular fracture treatment.

Methods: Patients with complex acetabular fractures treated at our trauma centre between January 2015 and December 2016 were retrospectively reviewed. Fractures were stabilized with an ilioischial plate via a modified Stoppa approach combined with the 1st window of the ilioinguinal approach. Interval between injury and surgery, operative time and intraoperative blood loss were recorded. Fracture reduction was evaluated radiographically with the modified Matta's criteria at 3 days postoperatively. Postoperative hip function was assessed using the modified Merle d'Aubigne and Postel clinical grading system over at least 1 year postoperatively.

Results: Twenty patients were included with an average follow-up of 17 months (range, 13-28). The mean time interval between injury and surgery was 7.0 days (range, 3-13 days), operative time was 2.0 hours (range, 1.4-3.2 hours), and intraoperative blood loss was 320 mL (range, 220-450 mL). Fracture reduction was excellent in 15 cases (75%), good in 3 cases (15%), fair in 1 case (5%), and poor in 1 case (5%). Final hip function was excellent in 13 cases (68%), good in 3 cases (16%), fair in 2 cases (11%), and poor in 1 case (5%). Bony healing was achieved in all cases and few complications were reported including recoverable obturator nerve injuries in 2 patients (10%) and traumatic arthritis in 1 patient (5%).

Conclusions: Anterior fixation of complex acetabular fractures with an ilioischial plate via the combined anterior approach yielded clinically satisfactory mid-term outcomes, providing a potentially effective alternative to the conventional treatment algorithm.


Effects of occupational hazard factors faced by the editors of sci-tech journals on their physical and mental health were analyzed.The causes of the occupational stress and job burnout were discussed and countermeasures were proposed.The author suggests that attention should be paid to the occupational health of sci-tech journal editors.It was pointed out that the occupational health of sci-tech journal editors and its influencing factors should be added into the scope of sci-tech journal editing research.


Turkish President Recep Tayyip Erdogan, upon the request of a student on social media, made a surprise visit to a boys' dormitory and had the suhoor meal with them during the holy Islamic month of Ramadan.


Two cases of neonates with severe multisystem anomalies, involving absence of external ears, malformation of the middle ears, atresia of the œsophagus, tracheo‐œsophageal fistula and multiple congenital cardiac defects, are reported. Many writers have described each of these anomalies, singly or in association with one or other of these defects, but none to date have reported all of these occurring in the one patient. These cases have certain features resembling the trisomy‐18 or deletion of long arm‐18 syndromes, but do not exhibit any of the musculo‐skeletal anomalies specific to these syndromes. This paper reviews these various theories with particular reference to possible clinical and genetic origins, and briefly reviews the pertinent embryology.


Evaluation of predict performance of five amino acid descriptors(z-scales、c-scales、ISA-ECI、MS-WHIM、PRIN) in peptide QSAR(Quantitative structure-activity relationships) with three dataset by support vector regression(SVR) is made in the article,and RBF is selected as kernel function.Using 'leave-one-out' cross-validation(LOO-CV),we suppose that radial basis function(RBF) is better than polynomial function and linear function,as long as our model is considered.Predicting accuracy of z-scales is slightly better than the other descriptors in SVR with RBF.Prediction capability of SVR in the same descriptor is better than other linear methods.Therefore,SVR is assumed to be a feasible method in peptide QSAR model.


This paper deals with the analysis of high efficiency small antenna like superconductor antenna. The superconductor antenna is useful to low frequency range because surface resistance of superconductor increased with the rate of square of frequency. Thus, the used antenna increases in size. For such a reason, the role of the matching circuit is very important in small antenna. In this paper, low loss antenna included the optimal structure of matching circuit is analyzed by using quasi-static approximation. To verify the results of this paper, input impedance and radiation characteristics of this antenna have been evaluated.


240 (1975). Recent Advances in Hemophilia. L. M. ALEDORT, Editor and Conference Cochairman. M. S. GILBERT AND S. 1. RAPAPORT, Conference Cochairmen. 241 (1974). Hemoglobins: Comparative Molecular Biology Models for the Study of Disease. H. KITCHEN AND S. H. BOYER, Edilors and Conference Cochairmen. J. S. CASS AND L. M. MEYER, Conference Cochairmen. 242 (1974). Properties and Functions of (Na+ + K+)-Activated Adenosinetriphosphatase. A. ASKARI, Ediror and Conference Chairman. 243 (1975). Biological Actions of Dimethyl Sulfoxide. S. W. JACOB, Editor and Conference Chairman. R. HERSCHLER, Editor. 244 (1975). The Biological Role of Porphyrins and Related Structures. A. D. ADLER, Editor and Conference Chairman. 245 (1975). Aquatic Sciences. J. C. BAIARDI AND G. D. RUGGIERI, Editors and Cochairmen. 246 (1975). Toxicity of Vinyl Chloride-Polyvinyl Chloride. I. J. SELIKOFF AND E. C. HAMMOND, Editors and Conference Cochairmen. 247 (1975). Biologic Effects of Nonionizing Radiation. P. E. TYLER, Editor and Conference Chairman. 248 (1975). Neurophysins: Carriers of Peptide Hormones. R. WALTER, Editor and Conference Chairman. 249 (1975). Thymus Factors in Immunity. H. FRIEDMAN, Editor and Conference Cochairman. W. S. CEGLOWSKI, Conference Cochairman. 250 (1974). Hudson River Colloquium. 0. A. ROELS, Editor and Conference Chairman. 25 1 (1975). Electrostatic and Electromagnetic Confinement of Plasmas and the Phenomenology of Relativistic Electron Beams. L. C. MARSHALL, Editor and Conference Cochairman. N. ROSTOKER, Conference Cochairman. H. L. SAHLIN, Editor. 252 (1975). Medical Consequences of Alcoholism. F. A. SEIXAS, Editor and Conference Chairman. K. WILLIAMS AND S. EGGLESTON, Editors. 253 (1975). The Biology of Cytoplasmic Microtubules. D. SoIFeR, Editor and Conference Chairman. 254 (1975). Fifth International Conference on Immunofluorescence and Related Staining Techniques. W. HIJMANS AND M. SCHAEFFER, Editors and Conference Cochairmen. 255 (1975). Chemistry, Biology, and Clinical Uses of Nucleoside Analogs. A. BLOCH, Editor and Conference Cochairman. R. K. ROBINS AND A. MIITLEMAN, Conference Cochairmen. 256 (1975). Mechanisms of Tissue Injury with Reference to Rheumatoid Arthritis. R. J. P~RPER, Editor and Conference Cochairman. C. M. PEARSON, Conference Cochairman. 257 (1975). Role of Magnetic Fields in Physics and Astrophysics. V. CANUTO, Editor and Conference Chairman. 258 (1975). Jecond Conference on Vitamin C. C. G. KING AND J. J. BURNS, Editors ond Conference Cochairmen. 259 (1975). Carcinofetal Proteins: Biology and Chemistry. H. HIRAI AND E. ALPERT, Editors and Conference Cochairmen. 260 (1975). Institutions and Science Public Policy. M. LANGER AND D. K. MILLER, Editors and Conference Coorganizers. 261 (1975). Environment and Society in Transition: World Priorities. B. PREGEL, H. D. LASSWELL, AND J. MCHALE, Editors and Conference Cochairmen. 262 (1975). Seventh Texas Symposium on Relativistic Astrophysics. P. G. BERGMA", E. J. FENYWS, AND L. Mom, Edilors. 263 (1975). Developmental Psycholinguistics and Communication Disorders. D. AARONSON AND R. W. RIEBER, Editors and Conference Cmhairpersonr . 264 (1975). Carriers and Channels in Biological Systems. A. E. SHAMOO, Editor and Conference Chairman. 265 (1976). Ethical and Scientific Issues Posed by Human Uses of Molecular Genetics. M. LAPP^ AND R. S. MORISON, Editors and Conference Cochairmen. 266 (1975). Pathobiology of Invertebrate Vectors


The effect of extraction method and technology on the amount of extracted pigment is studied,and the mordanting and dyeing technology of alkannin on cotton fabric are researched.The results show that the suitable extraction technology of alkannin by 100% alcohol is extraction bath ratio(quantity of alkannin/anhydrous alcohol) 1 ∶ 20~1 ∶ 30,temperature 40~50 ℃,time 2~4 hours.The suitable mordanting process is that treating with aluminum potassium sulfate of 5 g/L at 70 ℃ for 30 min under pH 3~4,and the optimal dyeing process is that dyeing at 60 ℃ for 30~50 min under pH 4.The dyeing liquor can be reused for 1~2 times.The color fastness of dyeings is dry crocking 4~5 grade,wet crocking 3~4 grade,soaping 4 grade.


More consumers are using social media to keep abreast of personal health and well-being issues. In addition to web portals (e.g., WebMD.com and MedicineNet.com), which serve as repositories of expert derived health information (Baker et al. 2003; Sillence et al. 2007), consumers are turning in large numbers to medical forums (e.g., DiabetesForum.com and DiabetesDaily.com for diabetes management, IBSGroup.org for IBS, etc.), where communities of people with shared medical issues exchange knowledge and experiences with their illnesses (Tustin 2010). On a large forum with several hundred thousand posts, it is very hard for users to find the most relevant posts just by using the search functions of the forum. Hence, there is a need for smarter visual navigation interfaces that can organize the relevant information more systematically and provide better pathways for accessing content.


Dauciform root is chracterized by short,carrot-shape,lateral roots with remarkably dense,long root hairs and facultatively formed in Cyperaceae.It is an evolutionary and important specialized root structure that enhance the acquisition of P and micronutrients from nutrient-impoverished soil where they grow long term.These species with dauciform root release an array of carboxylates(e.g.citrate,malate),phosphatase,proton,cation,phenolics,mucilage,etc.in the rhizosphere and thus mobilize insoluble nutrients in soil,especially enhance availability of P.With global P reserves are rapidly being depleted,there is a need to study and develop plants that are highly effective at acquiring inorganic P from P-sorbing soils.Therefore,the concept,morphology and structure of dauciform root in this review were first described.Then ecophyiological functions of dauciform root were summarized.At last,pointed out the future prospect of further research on dauciform roots.


AbstractThe venue for this year's Meeting of Teachers of Surveying was Bodington Hall, Leeds University, where the arrangements for some 70 delegates were in the excellent hands of W. G. Collins and J. B. Garner of the Civil Engineering Department.


This research identifies specific communication sensor features vulnerable to fog and provides a method to introduce them into an Advanced Framework for Simulation, Integration, and Modeling (AFSIM) wargame scenario. Military leaders use multiple information sources about the battlespace to make timely decisions that advance their operational objectives while attempting to deny their opponent's actions. Unfortunately, the complexities of battle combined with uncertainty in situational awareness of the battlespace, too much or too little intelligence, and the opponent's intentional interference with friendly command and control actions yield an abstract layer of battlespace fog. Decision-makers must understand, characterize and overcome this "battlespace fog" to accomplish operational objectives. This research proposes a novel tool, the Fog Analysis Tool (FAT), to automatically compile a list of communication and sensor objects within a scenario and list options that may impact decision-making processes. FAT improves wargame realism by introducing and standardizing fog levels across communication links and sensor feeds in an AFSIM scenario. Research results confirm that FAT provides significant benefits and enables the measurement of fog impacts to tactical command and control decisions within AFSIM scenarios.


In 2001, the Muscular Dystrophy Community Assistance, Research and Education Amendments (MD‐CARE Act) was enacted, which directed federal agencies to coordinate the development of treatments and cures for muscular dystrophy. As part of the mandate, the Centers for Disease Control and Prevention (CDC) initiated surveillance and educational activities, which included supporting development of care considerations for Duchenne muscular dystrophy (DMD) utilizing the RAND/UCLA Appropriateness Method (RAM). This document represents the consensus recommendations of the project's 10‐member Respiratory Panel and includes advice on necessary equipment, procedures and diagnostics; and a structured approach to the assessment and management of the respiratory complications of DMD via assessment of symptoms of hypoventilation and identification of specific thresholds of forced vital capacity, peak cough flow and maximum expiratory pressure. The document includes a set of Figures adaptable as "pocket guides" to aid clinicians. This article is an expansion of the respiratory component of the multi‐specialty article originally appearing in Lancet Neurology, comprising respiratory recommendations from the CDC Care Considerations project. Pediatr. Pulmonol. 2010; 45:739–748. © 2010 Wiley‐Liss, Inc.


ABSTRACT We investigated both the structural and functional consequences of modifying the hydrophobic, lipopeptide-mimetic oligo-acyl-lysine (OAK) Nα-hexadecanoyl-l-lysyl-l-lysyl-aminododecanoyl-l-lysyl-amide (c16KKc12K) to its unsaturated analog hexadecenoyl-KKc12K [c16(ω7)KKc12K]. Despite similar tendencies for self-assembly in solution (critical aggregation concentrations, ∼10 μM), the analogous OAKs displayed dissimilar antibacterial properties (e.g., bactericidal kinetics taking minutes versus hours). Diverse experimental evidence provided insight into these discrepancies: whereas c16(ω7)KKc12K created wiry interconnected nanofiber networks, c16KKc12K formed both wider and stiffer fibers which displayed distinct binding properties to phospholipid membranes. Unsaturation also shifted their gel-to-liquid transition temperatures and altered their light-scattering properties, suggesting the disassembly of c16(ω7)KKc12K in the presence of bacteria. Collectively, the data indicated that the higher efficiency in interfering with bacterial viability emanated from a wobbly packing imposed by a single double bond. This suggests that similar strategies might improve hydrophobic OAKs and related lipopeptide antibiotics.


Through the five years practice of setting up a series of the electrocardiologe electives for the clinical medical undergraduate students,we have explored the new pattern for training electrocardiologe talents.


It is demonstrated that the uptake and release of hydrophobic drugs/dyes by mesoporous silica nanoparticles (MSN) is critically dependent on the functional groups present on their outer surfaces. For this, amphifunctional MSNs are synthesized, possessing hydrophobic pores and hydrophilic functional groups on the outer surface. Further, the outer surface is modified with a different chain length of molecules, e.g., propargyl alcohol, triethylene glycol, and PEG (2000) via azide–alkyne click chemistry. The effect of these different surface functional groups on uptake of drug/dye is demonstrated with Nile red, proflavine (free base form), and rhodamine 6G. The uptake of these molecules is found to be inversely proportional to the bulkiness of surface functionality. To counter this effect, an alternate method of loading is proposed and demonstrated. Finally, the effect of these different functional groups on the release of loaded drug proflavine is studied, which supports the hypothesis that bulkier outer surface groups also hinder the release of drugs loaded in the porous MSN.


The recent loophole-free experiments have confirmed the violation of Bell's inequalities in nature. Yet, in order to insert measured values in Bell's inequalities, it is unavoidable to make a hypothesis similar to "ergodicity at the hidden variables level". This possibility opens a promising way out from the old controversy between quantum mechanics and local realism. Here, I review the reason why such a hypothesis (actually, it is one of a set of related hypotheses) in addition to local realism is necessary, and present a simple example, related to Bell's inequalities, where the hypothesis is violated. This example shows that the violation of the additional hypothesis is necessary, but not sufficient, to violate Bell's inequalities without violating local realism. The example also provides some clues that may reveal the violation of the additional hypothesis in an experiment.


The direct charmonium and bottomonium production rate observed at highpl in pp collisions at the Tevatron is factors of ten larger than predictions based on conventional perturbative &CD. We show that this excess can be accounted for by our model for soft colour interactions, previously introduced . . to describe in a novel way the large rapidity gap events observed at HERA. . (Submitted to Physical Review Letters) Typeset using REVTjjX *Work supported in part by the Swedish Natural Science Research Council and the U.S. Department of Energy, contract DE-AC03-76SF00515.


Abstract Peanut curing must proceed fast enough to avoid mold problems and harvest delays, and yet proceed slow enough to avoid milling quality loss. A new dryer heat control method, termed drying rate control (DRC), was developed to better meet the above criteria. DRC was tested and compared with humidistat control (HC) and conventional control (CC) using a bulk simulation model and laboratory curing tests. Airflow rates of 5, 10, and 15 m3/min/m3 were used. Simulation studies incorporated five years of actual weather data from Suffolk, Va. Laboratory curing tests were done on nine lots of peanuts over two years. Average curing times were the same for CC and DRC, but averaged 17% longer with HC. Estimated fuel costs were nearly the same for CC and DRC, but were 14% less for HC. Mold risk, percent splits in the grade sample, and volatile organic matter concentrations were nearly the same for all heater control methods. Percent skin slippage in ELKs, measured with a subjective test, averaged approximately ...


In the article socio-economic analysis of neighborhood is presented on the basis of big ethni-cally defined neighborhoods in Pretoria and the practice of the inhabitants thereof: communi-cations, activities, relation to environment, activities of individuals, form of neighborhoods. A neighborhood is defined as a form of interaction of natural and social environment.


Purpose – Major health benefits have been associated with the consumption of soy based foods. Non‐dairy beverage creamers made from soy protein will reduce cost and appeal to lactose intolerant consumers. The purpose of this study is to determine the knowledge and perceptions of beverage creamers among consumers in Accra, as a case study for many West African countries.Design/methodology/approach – Self‐administered questionnaires were used to evaluate the knowledge and attitudes of beverage consumers to the use of creaming agents.Findings – Chi square tests conducted on data collected during the survey showed no significant association between social status and consumption of beverages such as tea and coffee. Most respondents cream their beverages with dairy milk. They lacked adequate knowledge on non‐dairy creamers but would be prepared to use them if they are proved to be beneficial to human health and well being.Originality/value – Consumer preferences and perceptions of new foods can easily be swayed...


A lot of promising computer vision research has been conducted in order to automatically recognize facial expressions during the last decade. Some of them achieve high accuracy, however, it has not yet been investigated how accurately humans accomplish this task, which will introduce a comparable measure. Therefore, we conducted a survey on this issue and this paper evaluates the gathered information regarding the recognition rate and the confusion of facial expressions.


Variation in serum levels of CD44, which acts as an adhesion receptor involved in lymphocyte migration and binding, have been reported in some malignancies. The aim of this study is to compare serum levels of CD44 in children with sarcomas with those in healthy children.


Junior Enterprises (JEs) are non-profit associations whose premises encourage both personal and professional development. Research has shown that students associated with JEs believe that among the desired personal changes are enhanced commitment, and ability to deal with emotions and challenging situations. Thus, this research aimed to verify and compare the expression of personality traits, emotional regulation, and coping with stress in 159 junior entrepreneurs from Minas Gerais ( M age = 21.40, SD = 2.684), split into groups according to the time they have been working (G1 = up to 12 months; G2 = from 12 to 24 months; G3 = more than 24 months). The data were treated with descriptive techniques, comparison between groups, and network perspective. There were no differences between the groups regarding the variables of interest, but they showed a distinct expected influence for each one. The data showed the need to implement strategies for the personal development of the volunteers in the JEs.


Multichip mechatronic power packages have been developed in Motorola for automotive applications. Copper heat sink based metal substrates were used to improve thermal and electrical performance. In the early stage of development, mold delamination and die cracking have been observed after assembly. With some mold compound materials, die backside have large delaminated areas, while with other mold compound, delamination stops early but die cracks. Finite element analysis, incorporated with interface fracture mechanics method, has been conducted to understand these phenomena. Impact of mold material properties and package geometry on post-assembly delamination has been evaluated. Good agreements have been obtained between experimental data and the simulation results. The phenomenon of crack branching into the die was also studied. Finite element simulation can be used to predict whether and when the crack at the interface will turn and crack the die. With a thorough understanding of the failure mechanism, both mold delamination and die cracks have been eliminated in the final package development.


Carson, Research Professor of New Testament at Trinity Evangelical Divinity School, demonstrates a bracing understanding of our times and the cultural challenges faced by conservative Christianity. In his 1996 book, The Gagging of God: Christianity Confronts Pluralism, he offered an incisive analysis of postmodernism. In that work, Carson's primary focus was epistemology and the postmodern understanding of truth and its knowability. In this new book, Carson continues to focus on truth and knowledge, challenging the Emerging Church at the foundational level of Christian identity.


Typical Batik Tebo yet well know neven Tebos ociety, because the problem sare fearedlostits cultural value. This study aimed to describe about the craft of Batik Tebo which includeforms ofmotive, the meaning containedin the motif, as well astools andmaterials for batik making techniquesin the studio Mursida Tebo. The method usedin this researchis descriptive methodqualitatively. Collecting datain this studyis doneby usingthe techni ques of observation, interview sand documentation. Datareviewed andanalyzed byt he stepsof data reduction, data presentation. Data validation was donewith the extension ofobservation, increa sepersistene and triangulation.The results showed that Batik Teboconsists of 11. motif batik bambu runcing, motif batik sialang rajo, motif batik buah manggis,motif batik rebung nyengum, motif batik serat kayu rengas, motif batik tapak kudo, motif batik bungo tanjung dan buah sawit, motif batik tapak kudo buah sawit, motif batik bungo tanjung,motif batik bungo paku dan buah sawit dan motif batik pawn(koin). Batik technique used is the technique of batik yestaining. Keyword : Batik Tebo, Studio Mursida, TeboCentralDistricts


ABSTRACT The omnipresence of orientation, wayfinding and navigation tasks in everyday life calls for high-quality cartographic media that help people to solve their tasks in the best possible way. Modern maps should not only consider modern visualization techniques and design approaches but also knowledge on the map user's cognitive processing. Previous studies of cognitive cartography and spatial cognition identified grids as suitable cartographic elements that can enhance the accuracy of cognitive representations of geographic space. Grid lines form grid cells and these cells subdivide a map layout into different regions. These regions seem to contribute to a categorization of cartographically represented contents. The categorical organization of a map provides a superordinate spatial structure that can improve the recall of object locations. An important parameter influencing categorization is the distance between grid lines (spacing/separation). A previous study suggested 5 cm (paper distance) spacing as being suitable for an accurate performance in recalling object locations in topographic maps. Based on a recall-memory-paradigm adopted from experimental studies in cognitive psychology, the experiments reported in the present study take up this value and aim at specifying the ideal value of grid line spacing for object location memory. The results show that previous findings can be extended. The results allow the proposal of ideal grid line spacing in a 6.5-7.5 cm range. These spacing values help to reduce spatial distortion errors in the memory of object locations, especially in maps with a low amount of visual details.


Abstract 4894 Background Liver involvement is frequent in AL amyloidosis patients, and is found in 70% of cases in autopsy series. Histologic diagnosis of amyloid deposition is mandatory, preferably by biopsies of non-hepatic tissue, liver biopsy being associated with an increased risk of bleeding. FibroScan, a non invasive method for measuring liver stiffness, is used to measure liver fibrosis in patients with viral hepatitis. We postulated that amyloid liver deposition in AL could enhance liver stiffness and that may help for the diagnosis of liver amyloidosis. Methods 41 consecutive AL patients with systemic disease seen at the French Reference Center for AL amyloidosis were analyzed: 17 had liver AL, 23 cardiac AL, and 13 no liver or cardiac involvement according to the criteria defined by the Tours Consensus Opinion on Amyloidosis (2005). All had liver stiffness measured by FibroScan simultaneously with 76 controls: 16 healthy controls, 10 multiple myeloma and 50 consecutive patients chronically infected with hepatitis C virus (HCV). According to the manufacturer9s criteria, liver stiffness was interpretable in 32 (78%) of AL patients and in 68 (89%) of the control group. The Mann Whitney test with Bonferroni correction for multiple comparisons was used to compare the interpretable liver stiffness values between the groups. Results The liver stiffness was not statistically different between the healthy (median 4,6 range 2,8-6,5 KPa) and the myeloma controls (median 5,4 range 3,3-11,9 KPa) and both were considered as the negative control group. The negative control group had a liver stiffness significantly different from the HCV group (median 6,8 range 2,9-69,1 KPa, p Conclusion FibroScan is a useful non invasive tool which may suggest that a patient with undefined signs (enlarged liver, asymptomatic cholestasis, isolated monoclonal gammopathy) has liver amyloidosis and may help to define liver involvement in patients with proven amyloidosis, especially when liver stiffness reaches the cut-off value of 17,5 KPa. Disclosures No relevant conflicts of interest to declare.


This guide contains information resources on executive orders, immigration history and policy, and materials written by and about refugees and individuals from Iran, Iraq, Libya, Somalia, Sudan, Syria, and Yemen.


This paper discusses the innate capacity, expandable memory and essential to human learning . Music requests very intensely abilities of the auditory system as well as the motor cortex . The intense instrumental practice leads to neurological reorganizations differentiating the brains of musicians from no musicians . The musical perception among other peculiarities instrumental timbres identifies and recognizes the changes in height of a sound in a vast brain complexity . This is organized by building sensory maps forming networks that talk to each other continuously.O objective of this research was to review the literature that addresses the neuroscience knowledge and mental faculties involved in auditory processing and memory mechanisms that interfere with the performance of skills musical . The keywords used were : memory, music cognition and neuroscience . Vocational guidance consolidated neuroscientific studies may optimize the musical development. Index Term – music, brain, neuroscience, memory.


In the steel logistics park, the operational efficiency is repeatedly compromised due to excessive truck turnaround. For solving this problem fundamentally, the mixed loading relationship of multi-type steel products is excavated and the optimum solution for storage yard is proposed in the paper. Due to the limited stacking space, some products with small outbound demand have to be stacked together. A two-stage model is established to meet the stacking requirements for different outbound quantity of steel products. In the first stage, products with a small amount of stock will be mixed and stacked together according to certain rules. Then all products are allocated to specific yards in the second stage with the goal of maximizing the mixed correlation of steel products in the same yard to reduce the number of transitions for pick-up trucks. At the end, products in large quantities are placed in the stacking position close to the pick-up position. Experiments demonstrate that the proposed scheme is of great benefit to improve the operation efficiency of the logistics park.


Abstract Internal customers know what they want and when they want it. IT knows what resources it has and how much time it will take. the problem is the lack of synchronization between these two forces. By pushing back on the customer, IT can appear responsive and the customer can make a business decision regarding the best course of action given the reality of resources and time.


The author discusses the set of constants required to describe the external gravitational field of the Earth : a set of form factors and two scale factors. Some problems in relating the external field as derived from the motions of satellites to the quantities observed at the surface are mentioned. The fondamental parameters cannot be derived from the data without a knowledge of other astronomical constants, and it is shown how a general adjustment of data of different origins can be made. The results enable suggestions to be made about the way in which new conventional values of these parameters should be chosen.


A n emerging theme in medical education is the need to expose students to patients as early as possible in their undergraduate training. This is motivated by the desire to teach them a 'holistic' approach to patients and their problems, to encourage them to focus on the patient as 'an individual', and to give importance to patients' ideas, concerns and expectations, as opposed to focusing only on their medical problems. In addition, empathy may be learned through spending time in conversation with patients, listening to their stories, and sharing their experiences. Real patient encounters before the clinical phase of undergraduate medical education are now recommended to stimulate the integration of theory and practice.


It is important to study the natural frequencies of the BLDCM stator for reducing the noise of the BLDCM and optimizing control strategy.This paper constructs several 2D and 3D finite element analysis models with ANSYS,studies the influence of the structure and parameters of BLDCM on vibration mode and natural frequency.


ABSTRACT LED beacons operated on an isolated marine area are mostly employing the solar power supply system, and this system is well known for increasing the cost of management and maintenance. Recently, a number of researches and demonstrations on self-contained LED beacon is actively conducted to solve this issue. In this work, we propose an self-contained LED beacon with Bluetooth Low Energy function for an effective management of LED beacon. Firstly, control program structure is designed by expanding the status protocol of self-contained LED beacon, and then it is implemented into the form which administrator can easily understand. The control system visualizes the status and control data of self-contained LED beacon, and this enables the rapid decision-making of administrator. Also, minimizing electricity consumption of the beacon, it can transfer and update the status or light information of self-contained LED beacons with smart phone. 키워드 : 블루투스 저전력, 일체형 등명기, 제어 시스템, LED 등명기


We present a novel approach to generating 001 scripts by using agents with different person- 002 ality types. To manage character interaction in 003 the script, we employ simulated dramatic net- 004 works. Automatic and human evaluation on 005 multiple criteria shows that our approach out- 006 performs a vanilla- GPT2 -based baseline. We 007 further introduce a new metric to evaluate di- 008 alogue consistency based on natural language 009 inference and demonstrate its validity. 010


Purpose - The purpose of the paper is to investigate the global and regional influences on the domestic term structure of nine Asian economies. Design/methodology/approach - The dynamic Nelson Siegel model was used to extract the latent factors of a country's yield curve movements in a state-space framework using the Kalman filter. The global and regional factors of the yield curve were extracted using the dynamic factor model. Further, the Bayesian inference of Gibbs sampling approach was used to identify the influence of global and regional factors on the domestic yield curve. Findings - The results suggest that financial integration does not reduce the control of monetary authorities on the front end of the yield curve, and long-term interest rate is the potential transmission channel through which the contagion of the financial crisis spreads. Practical implications - The results of this study would help the monetary authorities to understand the efficacy of the monetary policy transmission mechanism. It also offers the global investors diversification opportunities for investing in the Asian bond markets. Originality/value - It is one of the earliest attempts to capture the global and regional yield curve movements and their impact on the emerging Asian economies yield curve. It contributes to literature by identifying the linkages in the long-term factor that is the potential channel through which crisis spreads.


We examine the measurement of tax expenditures, as well as review issues concerning the classification of tax expenditures generally. We use calculations from NBER's TAXSIM to illustrate some of the problems with the current methodology for estimating tax expenditures. Unlike most previous work on the topic, we focus on how features of the current tax system including the alternative minimum tax and sunset rules complicate and compromise the value of information provided by the tax expenditure budget.


The alternating copolymerization of carbon dioxide and epoxide to give aliphatic polycarbonate is one of the most promising methodologies for the efficient utilization of carbon dioxide as a direct raw material in the synthetic chemistry. In this article, recent author's examples of efficient catalysts for the alternating copolymerization of carbon dioxide and epoxide are described.


In order to reduce the cost of China's "home appliances going to the countryside" effectively, the centralized logistics centre in a province was put forward to carry out the logistics distribution. The model based on the exact centre-of-gravity method was built to analyze the location of these centralized logistics centers. Liaoning Province was taken as an example to show the process of calculation. Results show that the optimal location of the centralized logistics centre can make the logistics costs of "home appliances going to the countryside" reduced well. The government and the enterprises participating in "home appliances going to the countryside" can plan the logistics distribution centers with this result.


Disclosed is a fan fixing device, comprising an installation bracket used to house at least a fan, and at least one fixed piece which is fixed on the fan. The installation bracket comprises two opposite side walls; the end pf each side wall bends vertically to have a hem; two side walls of the installation hole are respectively provided with vertical hopper chutes; two sides of the fixed piece respectively develop into two retainer parts which retain the corresponding hems of the installation bracket when the fixed pieces are loaded into the respective hopper chutes.


In 1952 Hodgkin and Huxley were able to separate the m e m b r a n e currents which occur in response to step changes in membrane potential, upon voltage c lamping the squid giant axon, into two major current components : an initial transient component mainly carried under normal conditions by sodium ions and a delayed component mainly carried by potassium ions. Tetrodotoxin ( T T X ) specifically blocks the initial current mechanism when applied externally (Narahashi et al., 1964; N a k a m u r a et al., 1965). However, internal application of T T X at the same concent ra t ion does not block the sodium current. At higher internal concentrations, it becomes effective (Narahashi et al., 1966). O n the other hand, in the squid axon, te t rae thylammonium ion (TEA) blocks the delayed current when applied internally (Tasaki and Hagiwara, 1957; Armstrong and Binstock, 1965; Armstrong, 1966). Whereas cesium ion is able to block the delayed outward steady-state current when applied internally (Chandler and Meres, 1965; Adelman and Senft, 1966), cesium ion has no effect on this current when applied externally (Pickard et al., 1964). T h e object of this paper is to examine in some detail interactions among the five readily available group IA metal cations in contributing to a n d / o r inhibiting membrane conductances when the concentrations of these ions are varied externally.


Many people over the age of 65 are living with pain. It's a part of the nurse profession to assess and evaluate pain. Purpose: The purpose of this literature review was by existing research explore nurses knowledge and attitudes towards pain assessment and pain measurement in the care of elderly patients. Methods: In this literature review the databases Cinahl and Pubmed were used. Results: The results in this study are based on 10 articles. 7 quantitative, 2 qualitative and 1 were both methods was used. Factors that influenced how the patients' pain was assessed by the health care givers was experience and education, attitudes and different obstacles that made adequate assessments difficult, such as patients having cognitive impairment and lack of time to perform assessment. In general, the caregivers had a positive attitude towards education about pain assessment and a great intention to assess pain correctly. However, it could be shown that negative attitudes and prejudices against pain in the older patient and how it should manifest affected how the pain assessment was performed. Conclusions: Negative attitudes regarding aging that is still exists in our society is affecting the health care of the individual. The authors believe, in support of the reviewed literature, that education is an important way to improve and develop the pain assessment performance.


In 2005 and 2006, the influence of fertilization was investigated on forming of yield components and yield of three soybean varieties in sugar beet growing area. Varieties Korada, Supra and OAC Vision were grown. Number of plants per m2, number of pods per plant, number of seeds in pod, thousand seeds weight, yield of seeds, yield of stems and harvest index were examined. Variants of fertilization: I. non-fertilized control, II. LAV 27 % (40 kg ha-1 net nutrient
of N) in growing stage of first pair of true leaves unfolded, III. Humix komplet (rate 8 l.ha-1) applied in growing stage of first pair of true leaves unfolded (4 l.ha-1) and in growing stage of first flower buds visible (4 l.ha-1), IV. Humix komplet in rate 8 l.ha-1 applied in growing stage of first pair of true leaves unfolded. The yields of seeds and stems were high significantly influenced by variety, fertilization and year. The significantly highest yield of seeds was achieved by Korada variety (4,04 t.ha-1). Varieties OAC Vision and Supra reached yields in interval 3,74-3,84 t.ha-1. Split rate of
Humix komplet (III var) significantly influenced yield of seeds and stems. The fertilization have increased weight of seeds in proportion to aboveground phyto-mass weight, what was expressed by harvest index.


These Ecole polytechnique federale de Lausanne EPFL, n° 1295 (1994)Institut de microelectronique et microsystemesLaboratoire d'electronique generale 1 Reference doi:10.5075/epfl-thesis-1295Print copy in library catalog Record created on 2005-03-16, modified on 2016-08-08


The high-density Li0.95Na0.05FePO4 cathode material was synthesized through microwave heating, using a spherical sample prepared by co-precipitation method as precursor. The morphology, structure, electrochemical performance and the tap density of the materials were characterized by scanning electron microscope (SEM), x-ray diffraction (XRD), cyclic voltammetry (CV), constant current charge-discharge experiment and the tap density measurement. The results indicated that the samples have rules spherical or similar spherical morphology and simple pure olive-type phase. The Na doped Li0.95Na0.05FePO4 material showed excellent performance with a tap density of 1.63g/cm3. At room temperature, its initial discharge capacities reached 164.2 mAh/g, 151.5mAh/g, 130.5mAh/g at 0.2C, 1C, 2C current rates, respectively.


In this article, a common fixed point theorem in 2-metric spaces is proved. Moreover, the main theorems of [2] and [15] in 2-metric spaces are investigated.


Abstract Thin protective zirconium oxide coatings prepared via sol-gel with zirconium propoxide and acetyl acetone (acac) or hydroxypropyl cellulose as stabilizers have been successfully deposited onto iron substrates at low temperature. Electrochemical current density vs. potential scans showed a reduction of the iron dissolution current density and coating porosity in comparison to uncoated iron, with a strong decrease of these parameters around 5 orders of magnitude for a HPC concentration = 0.004 g/l. This result is expected as the steric effect of HPC. A mixed oxide layer of zirconium and iron was observed in SIMS depth profiles. The mixed oxide layer thickness showed a dependence on the acac molar ratio. Increases of acac shorted the overall film thickness, while the mixed oxide layer was thicker. ZrO2-HPC coatings displayed however, a thicker mixed oxide layer and additional increases of the zirconium intensity direct onto substrate surface. So a higher interdiffusion of zirconium into deeper layers and of iron towards coating surface was reached. XRD revealed that the mixed oxide layer is localized between the substrate and coating surface and possess crystalline structure. At a HPC concentration = 0.004 g/l no ZrO2 reflexes could be detected. ZrO2 crystals of 70 nm size were identified by TEM in ZrO2-acac coatings. However, ZrO2-HPC films showed an amorphous structure constituted of ZrO2 and iron oxide containing nanocrystalline zirconium oxide particles immersed in the mixed oxide layer. The crystals (monoclinic 112) size was between 5 and 10 nm. This result explains why there were not zirconium oxide reflexes visible in the XRD analysis. Obviously the ZrO2 crystalline particles are too small (less than 10 nm) to be detected by XRD so they appear as amorphous material [83]. The particles are immersed in a compact and amorphous mixed oxide matrix. The correlation between growth of the mixed oxide phase and decrease of dissolution current density suggests that it is the mixed oxide phase with zirconium nanoparticles that is responsible for the reduction of film porosity and the good corrosion protection properties of the films.


Sexual abuse of adolescents can have detrimental effects on their perceptions of their different future life-roles. We investigated such perceptions of students with a history of sexual abuse (n=163) as well as typically developing others (n=237). Participants completed the Life-role Inventory of the then called Human Sciences Research Council (Langley, 1990). Between-group comparisons were carried out. Adolescents with a history of sexual abuse reported negative perceptions of themselves fulfilling some of their roles in the future, being committed to these roles and attaching value to them, compared to typically developing others.


Cucumber,watermelon,pumpkins,squash,tomato,radish,wheat,flax,sesame,castor,flower bean,green bean are used to study the effect of extract from root of watermelon on seeds germination,weight increasing of root and seedling of different crop.The results showed that extract from root of watermelon on different crops in various organs are affected,cucumber and wheat seed's sprouting and weight of seedling increased,the effect is not significant;Flower bean germination and root weight as well as in pepper root weight also increased,but the effect is not significant;green bean root weight had significant increase;Radish seedlings weight also increased,and other crops have inhibitory effect.


Mr.Liao Li's "The Critical biography of Chen Cen" has comprehensively demonstrated the personality of Cen Cen,but in Cen Cen's thought there has not actually had the thought of retiring from world,which as Mr.Liao said,on the contrary Cen's mind was filled with the thought of exerting himself self to front,the thought of diligently striving for success for the family and the country.Besides,Cen also has high ambition and his thought filled with the conflict and pain that he can't fulfill himself in the reality.


A series of equations have been proposed to calculate take-off angle dependency of the elemental composition of layer-structured models from the experimentally obtained peak intensities of XPS. We have measured the take-off angle dependency of XPS peaks of O 1s, C 1s, Si 2p and Cd 3d from a well-characterized one-layer Langmuir–Blodgett (LB) film of polymerized cadmium 10,12-pentacosadiynoate on a silicon wafer substrate and have applied the newly proposed equations to deduce attenuation lengths of photoelectrons for every element in the layer-structured organic materials. From the best fitting between the theoretically calculated and the experimentally obtained data by the least-squares method, attenuation lengths for a monolayer film of polymerized cadmium 10,12-pentacosadiynoate have been evaluated to be 3.4, 3.7, 4.0 and 4.5 nm for the respective photoelectrons of O 1s (955 eV), Cd 3d5/2 (1082 eV), C 1s (1202 eV) and Si 2p (1388 eV) with the kinetic energy dependency ofE0.75. It is essential to use polymerized LB films and to confirm the surface structure of the film directly by suitable techniques such as atomic force microscopy, scanning electron microscopy or transmission electron microscopy.© 1997 by John Wiley & Sons, Ltd.


Atherosclerotic plaque can cause severe stenosis of the arterial lumen. Blood flowing through the narrowed artery may have different flow characteristics, and produce different forces on the plaque surface and arterial wall. The turbulence and force field in the lumen may have serious effects on vascular endothelial cells, smooth muscle cells and circulating blood cells. At the same time, different plaque characteristics will affect the flow field in the blood vessel, thus affecting the stress distribution on the vessel wall. This paper mainly focuses on the influencing factors of different plaque characteristics. The finite element models with different patch characteristics are established for numerical simulation. The effects of plaque size (degree of stenosis), plaque spacing and plaque relative rotation angle on the stress distribution of vascular wall were calculated.


Objective To studay on the therapeutic effects of early endoscopic retrogrode cholangiopancreatography(ERCP) and endoscopic sphincterotomy(EST) in acute biliary pancreatitis.MethodsThe clinical data of 420 patients with acult biliary pancreatitis were retrospectively analyzed,acult biliary pancreatitis were divided in to early endoscopic therapy group(218 case) and conservative therapy group(202 case),according to the treatment methods.The disappearance of abdominal pain,decrease of serumd and urine amylase leave,liver function recovery time,blood white blood cell recovery time,the mean days and costs of hospitalizations were observed in all patients.ResultsIn ERCP group,all patient were performed EST.The days of disappearance of abdominal pain and critical illness mortalities,were singnificantly shoter in the early early ERCP group than in the contral group.ConclusionThe early endoscopic management for patients with acult biliary pancreatitis not only lear etiology,and also can reduce expense,basic Nursing Workload and relieve pain,so pay attention to postoperative care can effectively reduce the incidence of postoperative complications


Trichoderma fungi are the most popular agents used in a biological control. Therefore, our aim
was to determine an impact of Trichoderma harzianum on the fungus Alternaria alternata - a
causing agent of the brown spot disease on tobacco. In vitro analyses were made in several
variants of double culture, in order to study the effect of diffusible and volatile metabolites.
There was strong reducing effect on the development of A.alternata with various mechanisms
of antagonistic influence. The volatile metabolites have also shown reducing effect.
Some abnormalities were observed in the pathogen's morphology both in diffusible and
volatile metabolites. The strong reducing effect of T. harzianum towards A. alternata can be
applied in biological control of this pathogen.


The European Convention on Human Rights (ECHR) guarantees certain human rights for the benefit of individuals in general within the jurisdiction of the contracting parties. It is established case-law under Article 3 that States are under an obligation to protect the physical and mental health of prisoners and detainees. In ensuring that the right of a fair trial is enjoyed effectively by disabled persons it is submitted that all the necessary facilities for an effective conduct of proceedings on behalf of them and an effective exercise of the right of defence in a criminal case against them should be provided by the State. The Commission considered an application brought by the parents of a child with mental and physical disabilities. By virtue of Article 14, States must secure the enjoyment of all Convention rights without discrimination on any of the listed grounds.Keywords: case-law; Convention rights; European Convention on Human Rights (ECHR); fair trial; physical disabilities


As one of the salient features of light, polarization contains abundant structural and optical information of media. Recently, as a comprehensive description of polarization property, the Mueller matrix polarimetry has been applied to various biomedical studies such as cancerous tissues detections. In previous works, it has been found that the structural information encoded in the 2D Mueller matrix images can be presented by other transformed parameters with more explicit relationship to certain microstructural features. In this paper, we present a statistical analyzing method to transform the 2D Mueller matrix images into frequency distribution histograms (FDHs) and their central moments to reveal the dominant structural features of samples quantitatively. The experimental results of porcine heart, intestine, stomach, and liver tissues demonstrate that the transformation parameters and central moments based on the statistical analysis of Mueller matrix elements have simple relationships to the dominant microstructural properties of biomedical samples, including the density and orientation of fibrous structures, the depolarization power, diattenuation and absorption abilities. It is shown in this paper that the statistical analysis of 2D images of Mueller matrix elements may provide quantitative or semi-quantitative criteria for biomedical diagnosis.


Present investigation attempts to isolate those personality factors which are predominent in accident-prone drivers. The study was conducted at the Passenger Bus Depot of the U.P. State Road Transport Corporation, Azamgarh. Hindi version of Cattell's 16 PF Test was used to assess the personality of these drivers. The study was conducted on a total sample of 40 drivers divided into two groups of 20 drivers in the each group. The first group included drivers with accident records (AG), and the second group included those driverss who were free from accidents (NAG). The accident group was further divided into two sub-groups, namely, multi-accident group (MAG) and single-accident group (SAG). There were 14 drivers in the SAG and 6 in the MAG.The results were analysed in terms of mean, S. D., and F-ratios. The findings of the study indicate that drivers involved in accidents are characterized by such personality traits as happygo-lucky, impulsive, gay, enthusiastic, shy, restrained, diffident, timid, tenderminded, dependent, overprotected, sensitive, apprehensive, worrying, depressive, throubled adequacy, anxiety and introversion. Those drivers who were free from accidents were found to be sober, prudent, serious, venturesome, socially bold, uninhibited, spontaneous, tough-minded, self-reliant, realistic, placid, confident, serence, adjusted and extravert.


This literature review addressed four questions. (1) In which populations other than cerebral palsy (CP) has the Gross Motor Function Classification System (GMFCS) been applied? (2) In what types of study, and why was it used? (3) How was it modified to facilitate these applications? (4) What justifications and evidence of psychometric adequacy were used to support its application? A search of PubMed, MEDLINE, and Embase databases (January 1997 to April 2017) using the terms: 'GMFCS' OR 'Gross Motor Function Classification System' yielded 2499 articles. 118 met inclusion criteria and reported children/adults with 133 health conditions/clinical descriptions other than CP. Three broad GMFCS applications were observed: as a categorization tool, independent variable, or outcome measure. While the GMFCS is widely used for children with health conditions/clinical description other than CP, researchers rarely provided adequate justification for these uses. We offer recommendations for development/validation of other condition‐specific classification systems and discuss the potential need for a generic gross motor function classification system.


One of the unique candidates to explore the evolution of physical surface processes on the Moon is Tycho, a dark haloed impact crater representing well-preserved bright ray pattern and intact crater morphology. Sampling of the central peak in such complex crater formation proves significant in terms of unraveling intriguing science of the lunar interior. With the current state-of-the-art radar technology, it is possible to evaluate the response of the geologic features constrained in the near surface and subsurface regolith environments. This can be achieved by modelling the dielectric constant of media, which is a physical parameter crucial for furthering our knowledge about the distribution of materials within different stratigraphic layers at multiple depths. Here, we used the applicability of Mini-RF S-band data augmented with a deep learning based inversion model to retrieve the dielectric variations over the central peak of the Tycho crater. A striking observation is made in certain regions of the central peak, wherein we observe anomalously high dielectric constant, not at all differentiated in the hyperspectral image and first Stokes parameter image, which usually is a representation of retrieved backscatter of the target. The results are also supported by comparing the variations in the scattering mechanisms. We found those particular regions to be associated with high degree of depolarization, thereby attributing to the presence of cm- to m- scale scatterers buried within a low dielectric layer that are not big enough to produce even-bounce geometry for the radar wave. Moreover, we also observe high rock concentration in the central peak slopes from DIVINER data and NAC images, indicating the exposure of clasts ranging in size from 10 meter to 100s of meter. Furthermore, from surface temperature data, these distinctive outcrops sense warmer temperature at night than the surrounding, which suggests the existence of thermal skin depth in such vicinities. Interestingly, we are able to quantify the pessimistic dielectric constant limit of the large boulder in the middle of the central peak, observable at the Mini-RF radar wavelength, as 4.54 + j0.077. Compared to the expected dielectric constant of rocks, this value is lowered significantly. One probable reason could be the emergence of small radar shadows due to the rugged surface of the boulder on the radar illuminated portion. From our analysis, we showcase the anomalous dielectric variability of Tycho central peak, thereby providing new insights into the evolution of the impact cratering process that could be important for both science and necessary for framing human or robotic exploration strategies.


I read with great interest the recent review ''Left-Sided and Duplicate Inferior Vena Cava: A Case Series and Review'' by Ang et al. (in press). The authors noted the association of left-sided Inferior Vena Cava (IVC) with germ tumors. The association of testicular germ cell tumors with retroperitoneal anomalies has been previously reviewed (Holt et al., 2007). We have previously reported on a case of duplication of the IVC in a 21-year-old male with a mixed germ cell tumor (Snow et al., 2007) (Fig. 1). In addition to our report, there are several other reports of duplicated IVC in patients with testicular germ cell tumors (Cohen et al., 1982; Klimberg and Wajsman, 1986). The tumors did not show a consistent laterality. These cases add further support to the hypothesis that there is an embryologic relationship between IVC malformations and anomalies of testicular descent and/or germ cell dysplasia that are associated with development of testicular tumors. Recognizing retroperitoneal venous anomalies in cases of testicular cancer has both diagnostic and therapeutic implications. Abnormal retroperitoneal venous structures have been confused with retroperitoneal metastatic disease (Cohen et al., 1982; Klimberg and Wajsman, 1986; Arisawa et al., 1999). These errors could lead to unnecessary treatment. Further, if surgeons are not made aware of the presence of venous anomalies before operation, this could lead to surgical complications. Clinicians diagnosing and treating testicular malignancies need to be aware of the possible association of germ cell tumors and retroperitoneal venous anomalies such as duplicated or left-sided IVC and retroaortic left renal vein.


Several studies have linked hormonal factors such as high parity and oral contraceptive use with an increased risk for invasive cervical cancer. This Italian hospital-based study examined the relation between estrogen therapy and cervical cancer risk.

Researchers interviewed 645 women aged 40 to 75 who were hospitalized between 1981 and 1993 …


Abstract Bacillus probiotics have been shown to possess several advantages over conventional probiotics, including the capacity to withstand heat during feed manufacturing processes and to be stored for a long time without losing viability, as well as the ability to survive and function in the acidic environment of the chicken gut. However, there are inconsistent results on the effect of Bacillus on growth performance of broiler chickens. The objective of this meta-analysis was to assess the effect of dietary Bacillus supplementation on feed intake (FI), feed conversion efficiency (FCE), and average daily gain (ADG) in broiler chickens. PubMed, Google Scholar, and Scopus databases were searched for studies that fed diets with and without Bacillus to broilers. Pooled estimation revealed that Bacillus supplementation improved FCE (standardised mean difference [SMD] = −0.33, 95% confidence interval (CI) −0.39 to −0.28) and increased ADG (SMD = 0.37 g/bird/day, 95% CI 0.28–0.46). In contrast, feed intake (SMD) = 0.03 g/bird/day, 95% CI −0.03 to 0.09) was not significantly different from controls. Subanalysis revealed that broilers fed with Bacillus at 0.1–0.5 × 106 colony-forming unit (cfu)/g had higher ADG than controls. There is evidence of significant heterogeneity (inconsistency index [I 2] = 80–93%) among the studies included in the meta-analysis. Meta-regression showed that studied moderators (i.e., Bacillus spp., duration of supplementation, and broiler strain) explained most of the effect. In conclusion, our results suggest that Bacillus supplementation at 0.1–0.5 × 106 cfu/g improved FCE and ADG in broiler chickens. However, it is recommended that more research be conducted to determine the Bacillus supplementation dose that optimises growth performance indices in broiler chickens.


Core-collapse supernovae are a useful laboratory to probe the nature of exotic particles. If axionlike particles (ALPs) are produced in supernovae, they can affect the transfer of energy and leave traces in observational signatures. In this work, we present results from two-dimensional supernova models including the effects of the production and the absorption of ALPs that couple with photons. It is found that the additional heating induced by ALPs can enhance the diagnostic energy of explosion, E_diag. For example, for moderate ALP-photon coupling, we find explosion energies ~0.6*10^51 erg compared to our reference model without ALPs of ~0.4*10^51 erg in the first ~0.5 s postbounce explored in this work. Our findings indicate that when the coupling constant is sufficiently high, the neutrino luminosities and mean energies are decreased because of the additional cooling of the proto-neutron star via ALPs. The gravitational wave amplitude is also reduced because the mass accretion on the proto-neutron star is suppressed. Although the ALP-photon coupling can foster explodability, including enhancing the explosion energy closer to recent observations, more long-term simulations in spatially three-dimension are needed to draw robust conclusions


Between 1983 and 1993, 680 patients with rectal carcinoma were treated at Ulm University. The resection rate was 84%. After undergoing radical surgery, 492 of the patients were followed up regularly at our hospital for a median of 66.9 months (range 4-177.6). Recurrences occurred in 172 patients (35%) and were diagnosed a median of 13 months (range 4-106 months) postoperatively; 9.4% had regional recurrences, 10.4% regional recurrences and distant metastases and 10.2% distant metastases. The 10-year survival rate of the patients in tumour stages I, II and III was 88%, 62%, and 32%. In patients with carcinoma of the midrectum, after anterior resection or abdominoperineal amputation the same local recurrence rate was found.


For obtaining the model of avionics SCI linc in opnet, some functional modules have been discussed based on two important SCI protocols--Bandwidth allocation and Queue allocation protocols. a applied model of SCI linc for avionics simulation is given and some key points for establishing model have been explained.


As a multiracial and multilingual society, Malaysia employs bilingual/trilingual education system. . At secondary level, there are three different types of schools in terms of medium of instruction (hereafter MOI). To explore the relationship between MOI and language use, language attitude, and further language shift among Chinese students, two questionnaire surveys are designed. The 423 respondents come from Confucian Private Secondary School with Mandarin as MOI and SMJK Confucian which adopts Malay as MOI in Kuala Lumpur respectively. The results show that students from the Chinese medium school maintain more Chinese dialects, such as Hakka and Minnan dialect, and hold more positive attitude towards them compared to those from Malay medium school. However, minor dialects such as Chaoshan dialect, Fuqing dialect, and Qiongwen dialect are loosing ground for both groups. As for the use of Mandarin and Cantonese, the dominant dialect in the Chinese community in Kuala Lumpur, in family domain, no significant difference is found between the two groups. To conclude, Chinese students from the Malay medium school are experiencing a rapid language shift towards Cantonese and Mandarin, while students from the Chinese medium school show a stronger degree of maintenance of Chinese major dialects.


Abstract Renal cancer, according to the Polish National Cancer Registry, was the cause of 4% of cancer cases in men and 3% of cases in women in 2010. Most often it affects men over 65, although it may also concern infants. In 2010, the number of reported cases for men was 2,700 and 1,900 for women. For the last three decades – up to 1990, the incidence of kidney cancer has increased significantly. Currently, it remains at the stable level of morbidity. One of the most significant issues of modern diagnostics and treatment of renal cancer is the problem of its heterogeneity brin-ging many difficulties in systematization and categorization of this neoplasm. The World Health Organization Classification of Renal Tumors has been published in 2004 and is currently supplemented with new classification units, which, according to ISUP (International Society of Urological Pathology), should be considered as separate groups of kidney epithelial cancers.


Education systems usually fall into two main types: the Continental and Atlantic systems of education. Countriesbelonging to the third world often follow after the characteristics of the continental system, however, thespecificities of the country may overwrite some characteristics of the original concept. This article aims tointroduce some specific aspects of the educational systems of Iran, Ethiopia and Myanmar through thecomparison of these systems. According to the data analysis, centralisation is relevant, but decentralisationtends to be strengthened in each country. Concerning their structure, similarities in the division of levels wereidentified, along with differences in duration and focus. Unsurprisingly, the curriculums are different in eachcountry; however, the basic subjects are almost the same. Finally, the grading systems use similar categories,although the underlying points providing the basis for the grades significantly differ. Comparing them cancontribute to their evaluation and further development.


The world has witnessed an information explosion in the past two decades. Electronic devices are now available in many varieties such as PCs, Laptops, book readers, mobile devices and with relatively affordable prices. This and the ubiquitous use of software applications such as social media and cloud applications, and the increasing trend towards digitalization, the amount of information on the global cloud has surged to an unprecedented level. Therefore, a dire need exists in order to mine this massively large amount of data and produce meaningful information. Text Classification is one of the known and well established data mining techniques that has been used and reported in the literature. Text classification methods include statistical and machine learning algorithms such as Naive Baysian, Support Vector Machines and others have widely been used. Many works have been reported regarding text classification of various languages including English, Chinese, Russian, and many others. Arabic is the fifth most spoken language in the world. There has been many works in the literature for Arabic text classification. However, and to the best of our knowledge, there is no recent work that presents a good, critical and comprehensive survey of the Arabic text classification for the past two decades. The aim of this paper is to present a concise and yet comprehensive review of the Arabic text classification. We have covered over 50 research papers covering the past two decades (2000 - 2019). The main focus of this paper is to address the following issues: 1) The techniques reported in the literature including. 2) New Techniques. 3) Most claimed efficient technique. 4) Datasets used and which ones are most popular. 5) Which feature selection techniques are used? 6) Popular classes/categories used. 7) Effect of stemming techniques on classification results.


pollution of piped supplies, but such endeavours as have been made to educate the people in this matter have met with limited success. After heavy bombardment it is often difficult or impossible to boil water owinig to interruption of the gas and electricity supplies, and simple chemical methods of purification which could provide a high degree of protection are unlikely to be widely used in the absence of any co-ordinated scheme for the education of the public and the provision of materials on the scale of that adopted for defence against poison gas. In the existing state of knowledge only a limited degree of protection could thus be expected from any measure which might depend upon the individual if left to his own devices, and we must therefore consider our last line of defence. Should there be good reason to fear an epidemic of enteric fever the surest means of prevention would undoubtedly be the intelligent use of preventive inoculation. Once decided upon this would have to be carried out without delay, and a high degree of success could be achieved only were it done under compulsion. The argument against this might well be overwhelming, and, if the risk were widespread, the performance of inoculation in the time available might be very difficult. We are thus driven back upon purification of water by the individual, and have to consider how the highest.degree of protection can be secured in this way. Plans must be carefully worked out fn advance, sufficient materials must be available, and the public must be educated in their use. We cannot afford to rely upon last-minute improvisation. One point needs emphasis-the effectiveness of any precautions which may lie behind the water undertakings is limited, and theirs must always remain the first line of defence. This fact, however, provides no justification for not bringing each line up to its maximum efficiency, and this can be done only by planning and organizing on a uniform national scale. Lieut.-Colonel E. F. W. Mackenzie, Director of Water Examination to the Metropolitan Water Board, to make doubly sure of the efficiency of an already highly efficient undertaking, has recently asked the Board to set up a consultative committee which shall provide a closer link between himself, the medical profession, and the public health service in the Board's area. The chairman of this committee is Lord Horder, and it has on it representatives of the London School of Hygiene, the Society of Medical Officers of Health, and the Royal Sanitary Institute. Londoners may feel grateful that this additional care is being taken on their behalf.


This paper explores international criminal law as a way to curtail the currently largely unfettered power of multinational corporations. With yearly turnovers that sometimes exceed the gross national product of states and corresponding political influence, such corporations not only theoretically can, but in the past repeatedly have, created detrimental effects for states and individuals in their sphere of operations. On the other hand, viable international solutions to subject multinational corporations to international rules and obligations comparable to those applicable to states are missing, except for voluntary partnerships like the UN Global Compact introduced by former UN Secretary-General Kofi Annan or efforts to make human rights obligations applicable to multinational corporations. The paper addresses the possibilities to extend the applicability of international criminal law to legal persons such as corporations. To that end, it shows how often-mentioned conceptual "stumbling blocks" such as establishing a corporation's criminal intent (mens rea), corporate complicity, and means of punishment for corporations can be overcome, and hghlights the potential international criminal law bears to provide remedies to victims not only to crimes committed by states and individuals but also by multinational corporations. Only in extending the scope of international criminal law to multinational corporations, it is argued, can the former live up to its role not only as a means to punish but also to protect.


The practices and values of management are increasingly shaping the management of life outside of work. Here, experts reflect critically on the implications this has for our everyday experiences of self and society. The book helps students to reflect critically on the relationship between management and changes in the organization of work.


XTENDING FROM MONT MICHEL southeastward to a point on the coast 1.8 112 kilometers northeast of Cape Sounion, the Agrileza valley cuts a swath about four kilometers long diagonally through the heart of the deme of Sounion. In its upper and middle part, where the valley floor is deep, the side walls of the valley are rock cliffs. The valley's lower third is less deep, and the border here, except near its end where the valley opens out onto a narrow coastal strip, consists of shelves of the upper marble which form broken terraces on either side. These terraces are bare of ancient remains, in contrast to the cliffs further inland upon which ancient farmsteads and other installations are perched.1 Indeed, my explorations of the lower Agrileza valley have so far turned up only one spot where there are any antiquities worth noting, an ancient grave with a rupestral inscription.2 The spot in question is on the west side of the valley, 200 meters north of and at the same contour as the Church of Ayia Paraskevi.3 Horizontal expanses of bedrock are here exposed at different levels. On the uppermost level one flat area of rock carries the retrograde inscription (P1. 32:a and Fig. 1, upside down in both):


The incidence of pertussis throughout the Netherlands, determined by notifications, rose suddenly in 1996 to reach 27.2 cases per 100 000 population, compared with 2.3/100 000 on average from 1989 to 1995. Earlier increases in 1989-1990 and 1994 reflected


7533 Background: Peripheral T-cell lymphomas (PTCL) have suboptimal outcomes with conventional chemotherapy. Autologous hematopoietic stem cell transplant (AHCT) is a therapeutic strategy for patients in first complete or partial remission (CR1 or PR1), with median progression-free survival (PFS) after AHCT of 36-48% by intent to treat (d'Amore et al JCO 2012, Reimer et al JCO 2009). Romidepsin (romi) is a histone deacetylase inhibitor approved for treatment of relapsed/refractory T-cell lymphoma. We present updated data of the first multicenter study to evaluate PFS of patients (pts) receiving maintenance therapy with romi after AHCT. Methods: This was a phase 2, open-label, investigator-initiated study (expected PFS 45%, desired PFS 70%; success achieved if 15 or more pts out of 25 were progression-free at 2 years post-AHCT). 26 pts transplanted in CR1 or PR1 were evaluable for the primary endpoint of 2-year PFS (Cohort 1, Table). An exploratory cohort (Cohort 2, n=7) enrolled pts either transplanted ≥ CR/PR2 (n=5) or with high risk histologies (n=2). Pts underwent AHCT with carmustine, etoposide, cytarabine and melphalan (BEAM) conditioning. Maintenance romi 14 mg/m2 started days 42-80 post AHCT; every other week through 6 mon, every 3 weeks through 1 year and every 4 weeks through 2 years post AHCT. PFS was estimated by Kaplan-Meier. Results: 47 pts consented; 13 did not receive romi (no AHCT, n=2; relapse before romi, n=3; cardiac comorbidity, n=3, patient declined, n=5). 1 consented pt did not have PTCL. 15 out of the first 25 pts in Cohort 1 were progression free after 2 years; median follow up of 31 mon (21 - 36 mon). Estimated 2-year PFS was 62% (45-83%, 95% CI); median PFS 30 mon (12.0- NA, 95% CI). In Cohort 2, estimated 2-year PFS was 43% (18 – 100, 95% CI); median follow up of 30 mon (range, 24 – 37 mon); median PFS 14 mon (5 – NA, 95% CI). Across cohorts, 5 pts required dose reduction. The most common toxicities (≥10% of pts, all grades) were fatigue (n=24, 73%), decreased platelets (n=16, 48%) and anemia (n=16, 48%). Conclusions: While the study did not meet its desired primary efficacy endpoint, maintenance romi was well-tolerated with an estimated 2-year PFS of 62%, greater than historical data. A larger, randomized study would be needed to determine the superiority of this approach. Clinical trial information: NCT01908777. [Table: see text]