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Uploaded by admin on September 09, 2010
September marks the beginning of the final quarter of the year; it also traditionally marks the return to school. So what better time to revisit the books of our youth? I remember buying my new term books at the end of August, before protectively wrapping them in newspaper and old calendars.
For me, Enid Blyton's Mallory Towers books were superb at describing the joy of the students' return to school: the joshing with the house mistresses and Matrons, the calling of 'hullo!', the return to the dormitory. Years later, I would get pretty much the same feeling as I read the Harry Potter series, albeit with the warm fuzzies of nostalgia. And decidedly less magic.
So, let's make this interactive. What books remind you of going back to school? What books best capture the feelings - elation, despair, resentment, resignation - that come with the return to school? The boundaries are loose - a book that describes the return, or maybe a book that's set in a school, or perhaps even a book that you read at school and haven't read since. I've shared some above and here are a few more:
Why don't you all share yours below in the comments?
Wow dude, this is extremely good information, much appreciated.
The children of Ananse by peggy Appiah , Mysterious ebony carver by Ibizugbe(where can I find this book? ) Forest of a thousand demons by Wole Soyinka
@Siren, here is a list of bookstores that carry our books, I'm sure one of them will have the book you're looking for:
Passport of Mallam Ilia and The Mysterious Ebony Carver
An African Nights Entertainment (Cyprian Ekwensi) & The Unknown Tomorrow( A Ghanian author, cant remember)


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In this city business hotel, everything is meant to provide guests with a pleasant stay. This property offers 99 modern and spacious suites and has a lobby with 24-hour reception and check-out service, hotel safe, currency exchange facilities, lift access, caf�, bar and restaurant. Further amenities include WLAN Internet access, room service and laundry service.
The hotel is situated in the Zona Viva, close to restaurants, bars, stores and the business district. The National Palace is 5 km away. The handicraft market is located around 3 km from the hotel, the National Museum approximately 5 km and the Mateo Flores Stadium about 4 km away. Antigua is approximately 47 km from the hotel, which is also just 5 minutes from La Aurora International Airport.
All suites feature individually regulated air conditioning, an electronic control panel, minibar, cable TV, work desk and full kitchen with fridge and cooker. Special rooms for non smokers are available. The rooms are en suite with shower/bathtub, hairdryer, double or king-size bed, tea and coffee making facilities, ironing set and a balcony or terrace.
The restaurant offers a full continental breakfast buffet and � la carte or set menu lunch and dinner.
Credit cards accepted are American Express, MasterCard and VISA.
Room Facilities:
Satellite cable TV
Tea Coffee
Iron and board
Double bed
King size bed
Individual airconditioned

subset: commoncrawl


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Nightblade by Ryan Kirk
Category: E-Book
Nightblade by Ryan Kirk
Audiobook Unabridged | English | November 16, 2015 | ISBN: 0692530169 | ASIN: B017XZTTA6 | mp3 | 1 ch 64 Kbps | 13 hrs 18 min | 367 MB
Ryuu is a boy orphaned by violence at a young age. Found by a wandering warrior, he learns he may have more strength than he ever imagined possible.
A quiet child, Moriko is forced into a monastic system she despises. Torn from her family and the forest she grew up in, she must fight to learn the skills she'll need to survive her tutelage under the realm's most dangerous assassin.
Young, beautiful, and broke, Takako is sold to pay for her father's debts. Thrust into a world she doesn't understand and battles she didn't ask for, she must decide where her loyalties lie.
When their lives crash together in a kingdom on the brink of war, the decisions they make will change both their lives and their kingdom forever.
If they can stay alive.


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Convenient for boats to Bomba
Labuhan village T: (0464) 21 280
Marina is a short walk from the port where the public boat service to and from Bomba is located.
By Samantha Brown
Last updated on 6th September, 2013.
The Travelfish newsletter is sent out every Monday and is jammed full of free advice for travel in Southeast Asia. You can see past issues here.


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Debt Consolidation Advice For Those Dealing With It
Debt consolidation may help in various ways if you start now. Struggling under heavy debt can cause anxiety and stress for anyone. Understanding debt consolidation is a good way to see beyond to a bright future. Learn what you can about the topic of debt consolidation here.
asian currencies Are the counselors at your debt consolidation company fully certified? Is there are certain organization that they are certified through? Is the company legitimate with the backing of well-known and highly reputable institutions? You can determine if they are worth using to consolidate your debt if you know this information.
If you're a home owner, you might need to think over getting your home refinanced and using that money to help with your financial situation. Since mortgage rates are showing historical lows, this could be a great solution. It is likely you will pay less monthly on your mortgage as well.
Do you currently hold a life insurance policy? You may want to cash your policy in if you wish to pay some debts. Talk to a life insurance agent in order to discover how much money you could get from your policy. You can sometimes borrow a part of what you invested in your policy to pay your debt.
When consolidating your debts, make sure to consider which debts are worth consolidating and which should be kept separately. For example, it makes little sense to consolidate loans with zero percent interest onto higher interest loans. Consult a financial planner to discuss your debts with so they can recommend ways to make wiser choices.
Get financial counseling to change your long-term spending habits. If you don't adjust your spending habits, you're going to keep having problems with debt. Once you have gotten the right debt consolidation loan, review your finances and spending behavior with a fine-tooth comb, and make some changes so that you don't find yourself in this situation again.
Research any debt consolidation company that interests you and try reading various consumer reviews for them. Doing this will help ease your mind that the future of your finances is in good hands.
You can obtain a loan from a person you know for debt consolidation. However, keep in mind that this can be dangerous because if you do not repay the money, you can destroy your relationship with this person. Only borrow money from someone your know if you have no other options.
What kind of fees will the company assess? Every fee should have an explanation attached, and it should be written down in the contract. It is also a good idea to find out how your payment shall be split amongst creditors. Ask the company you use for a schedule that will show you when payments will be paid out to every creditor.
Choose a debt consolidation service you can easily contact when you need help. Also, call your counselor if you have any questions or concerns. If you don't hear back from them quickly, you will just suffer anxiety.
Take the time to do the proper research on a handful of legitimate companies. The BBB is a great place to find out if your loan consolidation company is reputable because there is nothing worse than being in excessive debt and making a costly mistake with a an unscrupulous company.
People in debt make irrational choices sometimes. This is not necessary, and you know that now. You are well versed in how debt consolidation can help, so start using this advice to better your situation.


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I happened across some boot love while at Target this morning….
i heard them calling my name from across the aisle….so i did what any normal warm blooded girl
who should have been at home in bed instead because she wasn't feeling very well would do.
I bought them.
Bonus: They cost less then 40 boxes of Mac n cheese.
I am hoping i'm not the only girl who will feed her kids ramen noodles when the checking account
gets real low because she over spent on some must haves.
I mean really…..
i think it's necessary to look good while cooking ramen noodles.
Trader Joe's has their killer holiday packaging out now….
and i went a little overboard.
This time…i bought the box of peppermint chocolate covered marshmallows…
and let's just say….
the kids never had a chance to taste them.
I did come home with these though….
sweet sticks….so tasty…use one of them to swirl your hot cocoa around with.
Bonus: a low calorie food
I am getting my wrapping station all set up for Christmas…and i am loving all this cuteness i found on Etsy.
Bonus: friends and family get cute packages
When i was at Target…i came across these bird ornaments…
and they were only $1.
So cute.
Bonus: You can decorate a tree for less than $15 and still buy cute boots.
I realize the poor child has dirty fingernails and they are a bit on the long side.
The important part is that he is loved and fed and clothed.
This is my house at the moment….i'm a bit challenged in the clean up and put things away area.
I need therapy.
I also need someone to help me.
My cleaner is not calling me back…so it looks like i might have to step up the plate and do it myself.
I also want to know how long is normal to not unpack from a vacation?
I'm asking because…we have been home for almost 5 days now…and i still see my bag on the floor.
…and here is Lola's room….
she emptied her suitcase onto the floor and will live off of floor clothes for months.
I will say though…that even though the suitcases might not be unpacked…or that
my sofa has pillows all over the floors….
i did get a little Christmas decorating done today.
I even washed some sheets today.
I have two children bathed…and one to go.
I gave my bird fresh water and new food.
I am not sure i brushed my teeth this morning though.
I also forgot to buy some Ferria at Target because i was all consumed over grey boots.
I have ramen noodles on the dinner table.
I have a glass of wine waiting for me in the kitchen.
And one in the living room as back up.


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Technology can help just about anybody, including journalists and writers. And I am not talking about the tablets, PCs and laptops. I am referring to online tools that help a writer get on with writing and polish it along the way. Here are a few nifty tools that are just what the wordsmiths needed.
What's your writing style? Are you a metaphor-throwing Ed McBain or the light and frothy PG Wodehouse? Or horror bible Stephen King? Just write a few paragraphs and paste it on this website to know where you fit in. Hit the 'analyse' button and within minutes, it will tell you if you are an Ian Fleming in the making or James Joyce. The latter was what they said about the previous paragraph. Just one caution: It might become addictive. Then again, there's another spoof site that is just as much fun: I Really Write Like (http://www.richardclegg.org/previous/write). We pasted the previous paragraph and it said: "I actually write like an adolescent goth after a heavy night on the absinthe". Have fun but don't take everything with a creased forehead.
This tool offers a crash course on how to write clear, direct sentences without muddling up the subject and predicate. It analyses your writing (no matter what length) in a rigid structure and grades your writing. It color codes your writing into blue, purple, orange, green and cyan. It warns you of sentences dripping with adverbs, lengthy phrases and passive voices. The next time you want to polish your piece, you know where to head.
The best writing is simple. So weed out dense sentences, use plain words and score high on readability — there are five grade levels. You might know some of them from MS Word: Flesch-Kincaid Grade Level, Gunning-Fog Score, Coleman-Liau Index, SMOG Index and Automated Readability Index. Quite a mouthful, but all have a similar algorithm that ranks the ease with which you can read your stuff. So a score like 22 means, your writing can only be understood by graduates. Aim for the sixth grader or less. As Albert Einstein once said: "If you can't explain it to a six-year-old, you don't understand it yourself'. The site also throws up quite a few statistics that are just as useful. Like the number of characters, syllables, words and sentences in your manuscript. Revelatory, indeed.
Writing a novel or short story? Need some interesting sounding names for your characters? Perhaps, this online tool is just what you need. Pick the gender, language and nationality and the site will throw up a randomly generated identity. Complete with height, birthday, occupation, blood type and more. The only downside? The site can't suggest Indian names. But what's the Indian telephone directory for?
Free-writing is like meditation. Pray why? Because you just write, without thinking of grammar, syntax or spelling. It's just your thoughts on digital paper. And this site allows you to do just that. And only you are privy to it. You get one point for writing something and two points for crossing the 750-word daily yardstick. With charts to show your daily writing progress, it's a great way to know how fast you write and how good you are at it. Try it even if you are not a writer. As the site's founder says: "I've used the exercise as a great way to think out loud without having to worry about half-formed ideas, random tangents, private stuff, and all the other things in our heads that we often filter out before ever voicing them or writing about them. It's a daily brain dump."
~ Zahid Haroon Javali
Tags: 750 Words, edit, editing, fake name generator, hemingway editor, i write like, online tools, readability score, write, writer, writing


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From the Department of Medicine, Bassett Medical Center.
Correspondence to: Wisit Cheungpasitporn, MD, 1 Atwell Rd, Cooperstown, NY 13326; e-mail: firstname.lastname@example.com
Financial/nonfinancial disclosures: The authors have reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.
We read with interest the recent article in CHEST (November 2012) by Rho et al.1 The authors presented an interesting case of IgG4-related sclerosing disease.
We were wondering whether there was any significant lymphadenopathy. Asymptomatic IgG4-related lymphadenopathy is common, occurring in 80% of patients with autoimmune pancreatitis.2 Cough and dyspnea could be clinical manifestations of pulmonary sarcoidosis. Also, lymphadenopathy and pulmonary nodules are common in sarcoidosis. Interestingly, there was a biopsy specimen-proven report of the association between IgG4-related disease and sarcoidosis.3 This association is fascinating and we may have overlooked the diagnosis of IgG4-related sclerosing disease in the past in patients with or without sarcoidosis.
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See our latest news and events on our Facebook page!read more
Need to hire out our venue for an event? Suitable for a range of social events, parties and much more! Want to find out more?read more
Are you a student group and need to hire out our room? Download the student group venue hire booking form!read more
The Griff Inn Bar & Kitchen has been renovated to provide a relaxed and easy-going environment for our customers to socialise with friends and colleagues. We've introduced a great new food menu and offer options for those with special dietary requirements. The Griff Inn is available for private hire, bookings & birthdays please contact firstname.lastname@example.com
Monday: 10:00am - 6:00pm
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Weekends: Closed (Available for private hire)
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020 7882 8686
View our code of conduct here
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- 1 [countable] (symbol $) the unit of money in the US, Canada, Australia and several other countries You will be paid in American dollars. compare buck see also top dollar CulturemoneyThe US dollar is made up of 100 cents. The Department of the Treasury prints bills (= paper money) in various denominations (= values): $1, $2, $5, $10, $20, $50 and $100. US bills are all the same size, whatever their value, and measure about 2×6 inches/6.5×15.5 centimetres. All are green and are sometimes called greenbacks. On the front, each has a picture of a famous American. The dollar bill, for instance, shows George Washington, the first US president. An informal name for dollars is bucks, because in the early period of US history people traded the skins of bucks (= deer) and prices would sometimes be given as a number of buckskins. Buck refers to the dollar itself, and not to the bill. So although you can say 'He earns 500 bucks a week', you have to say 'If I give you four quarters could you give me a dollar bill?'The Treasury also makes US coins: pennies which are worth .01 of a dollar, nickels (.05), dimes (.10) and quarters (.25). There are also half dollars (.50) and silver dollars but these are not often seen. Pennies have a dark brown colour; all the other coins have a silver appearance.When you write an amount in figures the dollar sign ($) goes to the left of the amount and a decimal point (.) is placed between the dollars and the cents. If the amount is less than one dollar, the cent sign (¢) is put after the numbers. So you write $5, $5.62 and 62¢.Britain's currency is the pound sterling, written as £ before a figure. A pound consists of 100 pence, written as p with figures. Pound coins are round and gold-coloured. They have the Queen's head on one side and one of four designs, English, Scottish, Welsh or Northern Irish, on the other. The £2 coin is silver-coloured with a gold edge. Coins of lower value are the silver-coloured 50p, 20p, 10p and 5p pieces, and the copper-coloured 2p and 1p pieces. All are round, except for the 50p and 20p pieces which have seven curved sides. Coins are made at the Royal Mint. Paper notes (not bills), which have the Queen's head on one side and a famous person on the other, are worth £5, £10, £20 or £50.A pound is informally called a quid, a £5 note is a fiver, a £10 note is a tenner. Scottish banknotes have their own designs. They can be used anywhere in Britain, though shops can legally refuse to accept them. To prevent people forging (= making their own) paper money, designs are complicated and difficult to copy. To check that a note is genuine, a shop assistant may hold it up to the light to see if it has a narrow silver thread running through it.The decimal system now in use in Britain replaced the old pounds, shilling and pence, or LSD system in 1971. Formerly there were 12 pence or pennies in a shilling, and 20 shillings in a pound. The old coins included the farthing (= a quarter of a penny) and the half-crown (= two shillings and sixpence). There were notes for 10 shillings, £1 and £5.Gold guinea coins were used in the 18th century and were worth 21 shillings. Until 1971 prices were often set in guineas instead of pounds for luxury items, such as antiques and jewellery, for the fees of doctors, lawyers, etc., and at auctions, though the guinea coin had long since gone out of circulation. Some racehorses are still auctioned in guineas.On 1 January 1999 the euro system was introduced in 11 countries of the European Union. Britain chose not to be part of this first group and no date was fixed for Britain to start using the euro. However, many British businesses have euro bank accounts so as to be able to pay for goods and be paid in euros and a few shops in Britain accept payment in euros.
- 2 [countable] a banknote or coin worth one dollar Do you have a dollar? a dollar bill
- 3the dollar [singular] (finance) the value of the US dollar compared with the value of the money of other countries The dollar closed two cents down. Word Originfrom early Flemish or Low German daler, from German T(h)aler, short for Joachimsthaler, a coin from the silver mine of Joachimsthal ('Joachim's valley'), now Jáchymov in the Czech Republic. The term was later applied to a coin used in the Spanish-American colonies, which was also widely used in the British North American colonies at the time of the American War of Independence, hence adopted as the name of the US monetary unit in the late 18th cent.Idioms
nounjump to other results
BrE BrE//ˈdɒlə(r)//; NAmE NAmE//ˈdɑːlər//
(informal) to look/feel extremely good Wow, you look like a million dollars.
look/feel like a million dollars/bucksjump to other results
(informal) used to say that you are certain that something will happen You can bet your bottom dollar that he'll be late.
you can bet your life/your bottom dollar (on something/(that)…)jump to other results
Check pronunciation: dollar


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USPTO defends 'secret' patent system
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The US Patent and Trademark Office (USPTO) has been criticised after details of a little-known system for delaying "sensitive" patent applications were revealed.
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SAWS, patent, USPTO, FOI, Kilpatrick Townsend & Stockton
USPTO defends 'secret' patent system


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T-Pain - Rap Song ft. Rick Ross MP3
T-Pain's official audio video for 'Rap Song' ft. Rick Ross. Click to listen to T-Pain on Spotify: http://smarturl.it/TPainSpotify?IQid=TPainRap As featured on Rap ...
Rap Song
T-PainNappy Boy, ooh, wee Ooh wee Everybody say yeah Oh, oh, oh Hey, eh, eh, eh, eh We been messin' 'round for a long (Long time) A while now (While now, uh) And you already know what's on my mind (Mind) It's goin' down now (It's goin' down now) And I don't need no background music, girl I turn it loud now I got the gangsta feelin' And I'mma do somethin' to you To you, to you Oh We can take it over The Bay Where my Mistah F.A.B. at? (F.A.B. at, uh?) Or just put on that N.W.A. Comin[...]
T-pain ft Rick ross- Rap song w/ lyrics MP3
I DO NOT OWN THIS SONG, But I made this video! Like & subscribe for more music, and correct lyrics.
T-Pain - Rap Song (Feat Rick Ross) (Dirty) MP3
T-Pain - Rap Song (Feat Rick Ross) (Dirty)
T-Pain feat. Rick Ross - "Rap Song" LYRICS MP3
T-Pain feat. Rick Ross - "Rap Song" LYRICS.
T-Pain - Best Love Song ft. Chris Brown MP3
T-Pain's official music video for 'Best Love Song' ft. Chris Brown. Click to listen to T-Pain on Spotify: http://smarturl.it/TPainSpotify?IQid=TPainBLS As featured on ...
Best Love Song
T-PainTurn up the bass, turn up the treble, I'm about to take you to a whole other level! DJ turn off what you're playing I want the whole club to hear what I'm saying! Because this girl means so much to me, And now we're on the floor and she touching me. And if I wanna ta[...]
T Pain vs Kevin Hart Rap Battle (AKA Chocolate Drop) MP3
I have Free Beats for you ! Download Industry Quality, Full Length, Un-tagged, beats @ http://NiyaBeats.com - Offer ends soon ! Available for the first 25 people ...
T-Pain Feat. Rick Ross - Rap Song (Instrumental) MP3
The Lonely Island - I'm On A Boat ft. T-Pain MP3
Music video by The Lonely Island performing I'm On A Boat. (C) 2009 Universal Republic Records.
I'm On A Boat
The Lonely IslandWhoa, free boat ride for three. Now, who should I take? Kiv. And...T-Pain. Cool. (Shawty) Aw, shit! Get your towels ready, it's about to go down. (Yeah) Everybody in the place, hit the fuckin' deck. (Shawty) But stay on your motherfuckin' toes. (Yeah) We runnin' this, let's go... I'm on a boat (I'm on a boat) I'm on a [...]
T-PAIN "RAP SONG" ft. RICK ROSS BEHIND THE SCENES MP3
www.floridafilmhouse.com and www.nappyboyonline.com were there to get exclusive behind the scenes footage of T-Pain's single "Rap Song" which includes ...
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T-Pain - Buy U A Drank (Shawty Snappin') ft. Yung Joc MP3
T-Pain's official music video for 'Buy U A Drank (Shawty Snappin')' ft. Yung Joc. Click to listen to T-Pain on Spotify: http://smarturl.it/TPainSpotify?
Buy U A Drank (Shawty Snappin')
T-PainShawty snap (Yeah) T-Pain Damn, shawty snap Yung Joc (Shawty) Shawty snap Ay ay She snappin' Snap ya fingers, do ya step You can do it all by yourself Baby girl, what's your name? Let me talk to ya, let me buy a drink I'm T-Pain, you know me Konvict Muzik Nappy Boy ooh wee I know da club close at three What's the chances of you rollin' wit me? Back to the crib, show ya how I [...]
T-Pain "Rap Song" Instrumental wit Link MP3
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T Pain performs his new smash single RAP SONG to his Canadian Fans at the SUMMER JAM CANADA 2010 event in Kitchener Ontario.
T-Pain ft. Rick Ross Rap Song ((Slowed)) MP3
nt my song i js slowed it dwn.
T-Pain Ft. Rick Ross - Rap Song [CDQ/DOWNLOAD] MP3
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DJ Khaled "All I Do Is Win" feat. Ludacris, Rick Ross, T-Pain & Snoop Dogg / Victory In Stores Now MP3
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T-Pain ft. Rick Ross - Rap Song MP3
T-Pain ft. Rick Ross - Rap Song.
Thug Story Taylor Swift and T Pain MP3


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Performance Nutrition provides an overview of how nutrition can be used to maximize human performance. Starting with the end in mind, each chapter takes the reader from the science through to the practical application, making the science of sports nutrition accessible. The book shows how nutrition can be used to: reduce the risk of injury and illness for athletes; maximize strength gains in the gym; adapt effectively to endurance training; minimise the negative effects of concurrent training; improve competition performance (whether for football or for the Tour de France), and finally, lose weight safely and effectively to maximize performance. Packed full of information, each chapter takes the reader from the science through to the practical application. Illustrated with 40 diagrams and 18 tables.
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Big emoji are now a thing in latest version of iMessage in iOS as well as What'sApp.
Now you can have big emoji on your forum too!
Inspired by...
Hi i was just seaching on forums fox a fix, and i saw you are online.
I am Aljaz, i own this website.
I am running XF 1.5.9
Github: twitter/twemoji · GitHub
Twitter: Twitter Emoji (Twemoji)
Addon requests: Add-on - Twemoji addon
Click "like" ↘ to...
Separate names with a comma.


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The Deal
- $15 for one ticket to see A Bravo! Christmas (up to $25 value)
- When: Sunday, December 15, at 3 p.m.
- Where: Camas High School Theatre
- Section: general admission
- Door time: 2 p.m.
- Ticket values include all fees.
A Bravo! Christmas
Bravo! Vancouver's 60-voice chorale doesn't believe in spending the holidays alone. For their Christmas fundraiser, they welcome the Michael Kissinger Jazz Quartet on stage with them to add its groove to a smattering of classic carols. And they get the audience in on the action, too. Attendees of all ages unleash their inner baritones and sopranos as they sing along to "Jingle Bells," "Silent Night," "Joy to the World," and more. With so many voices in unison, it should hardly be a surprise if Santa stops by, prompting audiences to break into a melodious recitation of their Christmas lists.
Bravo! Vancouver
The Bravo! Vancouver chorale stays busy. Since its start in 1993 it has presented more than 100 concerts to more than 40,000 audience members and has grown to include 60 members. Weaving classical music with jazz and chamber music, the chorale brings the work of greats such as Brahms and Bach to the Northwest, and even travels to such far-off locales as Croatia. It often focuses its concerts on the major chorale works of the 18th through the 20th centuries, including Haydn's Creation and Mendelssohn's St. Paul Oratorio, while excluding Beethoven's little-known The ABC Song.
26900 Southeast 15th Street
Camas, WA 98607Get Directions


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The Epistle To The Colossians, Chapter 1 (5 Of 5) by Harley Howard
This content is part of a series.The Epistle to The Colossians, Chapter 1
Part 5 of 5
Dr. Harley Howard
Back to Colossians 1
This is why there are so many attacks about the person
and work of Christ. Not just the work on he cross,
but His current work, through the person of the Holy
Spirit operating in and through the church. As I said
already, "In establishing the greatness of salvation,
Paul established also the greatness of the person from
whom this salvation came, Jesus Christ."
All matters relative to this marvelous salvation rest
in the greatness of the person who gave it. Many
people have ignored this fact, to the hurt of their
own walk. Performance-based salvation is a failure.
Man's own efforts apart from Christ is a failure.
Rules and regulations produced by men, the doctrines
and teachings of men, all rob multitudes of true
worship as well as an understanding of the greatest
truth of all. That truth being that, "salvation is in
a person, and that person is Jesus Christ." In
Christ, we have (meaning that we keep on having) the
redemption through His blood, through His sacrificial
death. We have been brought back from a slavery to
which we were all sold into. Salvation is not
maintained by you or of your performance, it solely
exist because of Jesus Christ and Him alone. From
start to finish, salvation is always and forever,
Jesus Christ. In Christ we have redemption through
His blood, the forgiveness of sins. Now one of those
foundational truths that we need to understand
relative to who Jesus is, is to understand that Jesus
is the Savior. This truth we have already seen and
will see it more in this study. It is through His
redemption, through His blood that we have fellowship
and a relationship with God.
The second foundational truth relative to who Jesus
is, is the fact that He is God, the Son of God. This,
undoubtedly, is the most attacked truth in the history
of the church. Yet, an ...
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Featured Worship Backgrounds


text:
I want....
What are you wanting?
I want to go to the store and buy Burt's Bees face products. I've been wanting since I saw some good reviews on it recently.
And I want to take a bath, in a clay facemask, with a glass of wine, and a book.
What are you wanting?
Sent from my SAMSUNG-SGH-I997 using CurlTalk App
-to be with my best friend
-to finish this book
-the perfect deep conditioner
To be done with college so I can start my life.
Someone to shop for my clothes and dress me. I'm in desperate need of a new wardrobe and I'm too tired to think about it myself.
...a real job.
...a haircut.
...to see magic mike.
I want school to start.
...a man.
^Yep! Can he look like a real-life version of Mako, too, please?!
I'll settle for the next Mega Million jackpot, though.
I also want a house that cleans itself.
Put me down for a man( that excepts me for who I am), a house that cleans itself, and to see Magic Mike. Or how about a man that accepts me for who I am, cooks, cleans and is a private dancer.
Aside from that I want an Aston Martin V12 Vanquish, and maybe some new dresses & shoes.
Worn out iPhone. Need I say more?
I want to race against an Olympian in like a meter race, I just think the footage would be hilarious to watch.
i want to stay here in Ottawa...
I want my new apartment to be DONE (was supposed to be done Jul 1).
I want my knee to stop hurting (it's interfering with my work)
I also want about 100K, that would solve all my financial issues right now. Plus some for a holiday!
I want my husband to get a job teaching! Summer teaching positions are great but only if they turn out to have a permanent job in the end!
I'll try to keep this down to earth...
To be able to paint better.
I finished making over a dresser today and LOVE it...except for when I look close at the paint job. Maybe it was the lack of good tools, but it was a frustrating and disheartening process. I assumed painting was way easier than that. I'm relieved it actually looks as decent as it does though, from a couple feet away.
More female friends.
My boss. Ha.
One of the smocked dresses here, which I have this board and a curly in particular to credit for :)
A great winter coat (CA winter..), suitable for rain, warm but not too bulky, with a hood.
To take out time to read more.
- The power to be turned on in my new home so I can officially move in.
- Cooler weather
- for my husband to have a great birthday this weekend.
Sent from my PC36100 using CurlTalk App
-a stable job, I'm so over this temp crap. I had a better time w/this company in NY
-some more friends
-go home to visit and stuff my face
-new soft bed
-my eye brows threaded
-my damn couch to be delivered already!!! It's been 4 weeks, I should have it by now.
I want it to be 5:00.
I want a professional to come in and help me get organized in my apartment.
I would like another dog, or possibly a cat, but I know I shouldn't. :(
a really good, deep tissue massage and a prime rib dinner w/ a mojito
eta - OK, three mojitos
to get over to the library today. Just finished "The Chaperone" yesterday and am bookless!
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Titus and Roni(2010)
A novel by Gregory Dark
Two parents who, in facing death, face life. Perhaps for the first time. Titus, as well as being a father, is a grandfather. He has been kidnapped by his son in Colombia; Roni is a Glaswegian mother whose son, in twenty-four hours, will be executed by lethal injection. They are two novellas which, whilst they could exist separately, also complement each other. They are stories of doom, but not of gloom; stories, certainly of tragedy, but ingrained with both comedy and optimism. Their two principal characters surrender in order to fight on and traverse despair to find hope. They are two unremarkable people who, in finally accepting death, triumph over life, and become thereby remarkable indeed. Certainly, you will cry with Titus and with Roni, but also you will laugh with them. You will despair with them, and clutch at the same straws. Written with Dark's customary elegance, Titus and Roni is as mellifluous in its telling as it is compulsive in its tale.
Used availability for Gregory Dark's Titus and Roni
See all available used copies of this book at Abebooks UK or Abebooks US
Paperback Editions
August 2010 : UK Paperback
|Title: Titus and Roni
Author(s): Gregory Dark
ISBN: 1-84694-341-8 / 978-1-84694-341-6 (UK edition)
Publisher: Roundfire
Availability: Amazon Amazon UK Amazon CA
Genre Pages


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|<< Previous book
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High Dominion(1981)
A novel by Janis Flores
She was the victim of one man- and the deciever of another. Lovely, rebellious young Kate Beauvais willingly surrendered herself to the persuasive Englishman she loved, Roger Templeton- only to have him cast her aside when he married a proper young lady who was everything that Kate refused to be. Kate was secretly pregnant with Roger's child when she wed the arrogant, iron-willed American, Page Taggart- and was taken by him across the seas to the empire he was carving out of the raw and violent Colorado territory. Thus the seeds of dynasty and destiny were planted... in an act of shame and guilt that returned to haunt the Taggart generations as the fire in their blood threatened to destroy all that their driving ambition could build... High Dominion. A magnificent woman. An unforgettable family. A novel with all the power and passion of life, love and lust.
Used availability for Janis Flores's High Dominion
See all available used copies of this book at Abebooks UK or Abebooks US
Paperback Editions
October 1981 : USA Mass Market Paperback
|Title: High Dominion
Author(s): Janis Flores
ISBN: 0-451-11106-0 / 978-0-451-11106-7 (USA edition)
Publisher: Signet
Availability: Amazon Amazon UK Amazon CA
Genre Pages


text:
Ospho and Cold Galv
My rear window channel is a constant source of rework. Its always rusting and I am forever stripping it down, treating it with one thing or another and repainting. I was thinking about doing ospho and then cold galvanizing it this time. Has anyone tried this? Ive used them separately but never together. Any side effects (i.e. cracking up, poor adhesion )? Thanks
I use Ospho but epoxy primer seams to work best to seal it all up...Have you tried using an epoxy? I'd have to say it sounds like your not getting all the rust out ,use the Ospho to remove rust NOT convert it...Some stiff wire wheels will help a lot..or a recirculating spot blaster...You are taking the glass out , right??????
I'd suggest emailing the Ospho restoration expert. DBM seems to know the product really wellm maybe even as well as their restoration expert.
Years ago the bottom of the rear window channel disintegrated with rust. I removed the rusty metal and rebuilt it with fiberglass. The problem now comes in from the bottom of the window channel going down about 4 inches. This area is vinyl covered and the metal underneath is heavily pitted and has many holes. For striping I typically use a 4" wire wheel on a side grinder, a D/A with some rough grit, and then a Dremel in the pitted areas with a cut off blade (trying to scale but not remove the metal). I've used epoxy primer in the past but honestly I didn't think much of it, probably a mistake from what I'm hearing. I'll give it another shot, along with Ospho. This is a tuff area because of the vinyl keeping moisture against the finish. Thanks for the replies, Ill post some pictures.
some pics would be nice...just remember that after cleaning up the rust and then applying the ospho it must be epoxied THEN fiberglassed.otherwise the glass wont stick very well to the metal and although fiberglass isnt near as good a repair as some new metal, a glass repair should last 2-3 yrs
5 Attachment(s)
I hit it with a wire wheel and put one coat of Ospho on. Keep in mind some of the areas showing filler are fiberglass backed and have no metal behind them. I'm trying not to dig too deep in these filled spots, not to take out the existing fiberglass backing. Next, I plan on hitting it with a Dremel with a cutoff wheel and conservatively, removing more metal around bad pits. Ideally Id like to redo the metal but I don't have the equipment of the $ so I'll be working with this.
Well,cutting it out is the best bet,but eastwood has some good stuff.check this out.
Heres a couple things I noticed right off;
Thats going to be a hard piece of glass to find so if your not going to remove it then cut up some cardboard and duct tape it down so you protect it better,and your paint finish looks pretty good so cover that too...
bondo will soak up just about anything and you'll have problems getting anything to stick so clean out that old bondo...
Thats a very good wire wheel ,its one I use a lot,after the ospho drys wire wheel it again and reapply the ospho...something I do is wire wheel it while its wet....when your ready ,scuff it up good ,clean it with a wax & grease remover and prime with epoxy BEFORE using any fillers,fillers dont like to stick to ospho treated metal but epoxies stick well and fillers stick to epoxies well ...when your all done sanding, seal it all up with epoxy again...
As long as you know,those panels are wasted and need to be repaired with metal for a long lasting repair and this is just a temporary fix, its probably the best way to get the longest lasting repair you can but anything more than two years is a gift....
I'm having second thoughts on the metal replacement. I'm a little hesitant though the last guy I used to fix an old deck lid warped it badly. Mig welded it instead of tiging it and used 1/4" plate. $350 and 2 gallons of bondo later I had a mediocre lid that weighed about as much as an engine block. I ended up getting another lid. Thanks for looking close. I thought someone would say something about the window if they did. But yup, I got a replacement to put in. Junkyards are a powerful place in the South. Thanks youre a big help. I'll post again when I decide how I want to go.
Theres nothing wrong with mig welding you just found an idiot that didnt know what he was doing as far as welding sheetmetal goes....Where are you in S.C.????
2 Attachment(s)
I've decided to go with what I have. I put on ospho, grinded and wire wheeled times 5. Finally I epoxy primed. I waited for activation and sprayed it but it was still very watery going on. When in hardened it created what's like a plastic shell. Thanks for the heads up on this, an eye opener. I think years ago I used laquer primer or something else, it was thick put it didn't look like this.
One thing I thought of is a good seal. There has to be moisture and /or rust existing after the repair has been made. Check for water leaks after the job is done, also check the under side of the rusted metal for more rust, wire brush it down, ospho and seal with epoxy primer.
If your trying to fiberglass that mess it will come back to bite you. At best it will be a temporary repair. What you use for primer wont make that big of a difference. You really need to cut it out and rebuild with new metal then finish it off with epoxy and body filler and paint from there. I know a lot of work but only way to get any time out of your repair.
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Pillar fire hydrants by PAM
Search product
C9 Plus
Valves and hydrants
The C9 Plus pillar fire hydrant with visible intakes is a product that can be customized with a logo. It exists in collapsible and non-collapsible versions and also in a very short non-collapsible version:
- box with a bend or straight box with a duck foot bend.
- head adjustable by degrees to 360°
- possible option for STORZ, AWWA and BS fittings
- collapsibility indicator on the collapsible versions
- very short version for car parks and tunnels
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Selection of 4 products from
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The tasty High Energy Suet Cake from Dawn Chrous is suitable for all year round feeding. This a suet cake with seeds and comes in easy open tear down packaging with a hanger.
All prices include VAT where applicable. *The freephone number is free from most UK landlines only, mobiles are usually charged so we'd recommend calling our landline from your mobile or internationally.
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text:
Cannes festival lineup mixes Hollywood star power, world cinema
By Alexandria Sage
PARIS (Reuters) - Hollywood star power will vie with world cinema and a large crop of French films, including New Wave director Jean-Luc Godard's latest, for the top prize next month at the 67th Cannes film festival, the world's most important cinema showcase.
Godard's "Adieu au Langage" will bring the accustomed Gallic flair to the swanky festival on the palm-lined French Riviera, whose top Palme d'Or prize can significantly boost a movie's revenue and awards potential.
Tommy Lee Jones, Meryl Streep and Hilary Swank in the frontier drama "The Homesman" will add Hollywood pizzazz.
The 18 films announced on Thursday in the prestigious main lineup include entries from Canada, Russia, Turkey, Italy and Japan, highlighting the international breadth of what Artistic Director Thierry Fremaux called "cinema's great rendezvous".
"What is important to us is that the selection at Cannes is a voyage in the world of cinema and in the world overall," Fremaux told a news conference of film critics and journalists.
One of the world's oldest film festivals, Cannes is a glamorous affair marked by a much-watched red carpet, a phalanx of tuxedo-clad photographers, luxury yachts bobbing in the old port and a rotating cast of autograph-signing celebrities.
Featuring in the main lineup are two female directors - Italy's Alice Rohrwacher with "Le Meraviglie" and "Futatsume No Mado" (Two Windows)" from Japan's Naomi Kawase - with Oscar-winning New Zealand director Jane Campion leading its jury.
Campion is the first and only woman to have won the Palme d'Or, for "The Piano" in 1993, and the paucity of female directors has been criticized in recent years. Continued...


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News About 2014 Mackinnon Stakes
Atzeni Happy with Farraaj Ahead of 2014 Hong Kong Cup
13 of the world's best stayers will contest the Group 1 Hong Kong Cup (2000m) at Sha Tin on December 14, including the Roger Varian-trained Farraaj.
The five-year-old gelding travelled to Australia during ...
2014 Maribyrnong Plate Field – Emirates Stakes Day Opener
The final Melbourne Cup Carnival race day is this Saturday's Emirates Stakes Day at Flemington with the day's racing action kicking off with the two-year-olds in the Maribyrnong Plate 2014 field.
Running as Race 1 ...
2014 Mackinnon Stakes Results: Happy Trails Wins 5th for Oliver
One of Australia's premier hoops Damien Oliver celebrated his fifth Mackinnon Stakes victory on Victoria Derby Day this afternoon with the always honest Happy Trails atoning for a luckless Cox Plate run seven days ago with his third Group 1 success.
Oliver has ...
Mackinnon Stakes 2014 Odds Update
One race before today's marquee race, the Victoria Derby, a field of stayers including a number of potential Melbourne Cup starters will face off in the 2014 Mackinnon Stakes.
Due to jump at 3:00pm (AEDT) as Flemington Race 6, this year's $1 million ...
Rising Romance Primed for Mackinnon Stakes
Running a close second to talented Japanese raider Admire Rakti in the featured Group 1 Caulfield Cup (2400m) last time out, trainer Donna Logan is confident four-year-old mare Rising Romance is the runner to beat in Saturday's Group 1 Mackinnon Stakes (2000m) at Flemington.
2014 Mackinnon Stakes Betting Tips
A field of 14 top middle-distance runners will get their last chance at Group One success for the spring racing season this Saturday in the Group 1 Mackinnon Stakes (2000m) at Flemington.
With all but three of ...
Payne Confident of Mackinnon Stakes Success for Criterion
Unlucky to be blocked for a run and hampered when seventh in the featured Group 1 Cox Plate (2040m) last weekend, trainer David Payne is confident of a return to the winner's circle in Saturday's Group 1 Mackinnon Stakes (2000m) for Criterion.
Moody Won't Change Tactics with Brambles in 2014 Mackinnon Stakes
Trainer Peter Moody learned a valuable lesson when Brambles finished fourth in the Group 1 Crown Golden Ale Caulfield Cup (2400m) last time out, which was to not change any tactics with the six-year-old gelding.
He'll be following this ...
2014 Mackinnon Stakes Betting Update
14 middle-distance runners will start the Group 1 Mackinnon Stakes (2000m) this Saturday at Flemington after reigning champion Side Glance was scratched from the field earlier today due to a wrenched fetlock.
The $1 million Mackinnon Stakes is one of four Group One races running as ...
Side Glance Scratched from 2014 Mackinnon Stakes
Defending Mackinnon Stakes champion Side Glance will no longer get a chance to win back-to-back in the $1 million feature race after being scratched from the race on Thursday morning.
The UK galloper had been paid up for the race on Wednesday, drawing ...


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In manufacturing self-lubricating components for the tool and die industry, the SelfLube Company uses graphite and graphene in their everyday business. Graphite, which has been used since ancient times, was always thought to be pretty well understood – but the reality is it has always been a strange substance. It is one of the few materials that doesn't expand when heated or shrink when cooled (i.e., it has zero coefficient of linear expansion). It isn't a metal, but it conducts electricity like a metal. And, when reduced to a single layer, Graphene, the name given to a single sheet of graphite, turns out to be the strongest material known – 100 times stronger than steel. It is not just a good conductor of electricity; it is the best-known conductor of electricity. And, it is slippery, very slippery.
Month: January 2012
Carbon nanotubes set to shake up smart window market
A new market research report prepared by NanoMarkets and published by Smart Window Markets – 2012 has earmarked carbon nanotubes as the most likely replacement for current smart window technology.
As reported here before, carbon nanotubes have featured in the story of graphene for some time. Essentially a rolled form of graphene, nanotubes are proving to be at the forefront of developments in many different market sectors, with uses as diverse as nanosized needles for medical use to super light but strong windmill blades. In this latest report carbon nanotube and silver nanostructure inks are suggested as a replacement for the currently dominant ITO technology.
iNanotube for iOS — Animated, Engaging Visualizations of Nanotechnology
It's been available for several months now but I'm sure the developer of this brilliant app will be happy with a bit of free publicity; iNanotube 1.1 for IOS allows customers to style and create a nanotube (an atomic sized) making use of the app's easy program. Construction and treatment of these small wires is easily obtained through the touchscreen interface, which allows manipulating a piece of graphene into the form of a nanotube. The app provides immediate online design of the small components, made from the most effective and stiffest material yet found, which are too small to be seen with even the highest resolution microscopes.
Stevens Professor Makes Graphene-Based Inkjet-Printed Electronics
Along with partners in the Army and other researchers at Stevens Institute of Technology, Dr. Woo Lee the George Meade Bond Professor in the Department of Chemical Engineering and Materials Science in the Schaefer School of Engineering and Science at Stevens is advancing printed electronics through the recent demonstration of a method to inkjet print electrical energy storage devices using graphene. Made of carbon sheets one atom thick, graphene has quickly become a go-to material for the next-generation of nanoscale and microscale devices. Dr. Lee's team was recognized with the Academic R&D Award at Printed Electronics USA 2011 for combining the potential of graphene with precision inkjet printing technologies.
Graphene Oxide's effectiveness as a nanomedicine.
Medicine is one of the highest achievements of the human species and graphene is about to play its part in the most recent and exciting developments in the discipline; that is in the emerging domain of nanomedicine. Concerns for health and well-being have inspired some of the boldest innovations in history and nanomedicine continues in the great tradition of these pioneering advances. Born of interdisciplinary work in the fields of bioengineering, physics, chemistry and medicine, nanomedicine is increasingly looking to the material properties of graphene to assist in some of its most interesting projects.


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- Weight Gain Shockers Slideshow Pictures
- Take the Quiz on Belly Fat
- The Best Diet Tips Ever Slideshow Pictures
Quick Guide12 Reasons to Love the Mediterranean Diet in Pictures
Why is the Mediterranean diet beneficial to your health?
When trying to understand what the Mediterranean diet does for your health, just remember that "it's what inside that counts." The nutrients and phytonutrients in the foods, beverages, herbs, and seasonings are responsible for the health benefits. These nutrients have benefits ranging from anti-inflammatory, antiviral, antimutagenic, antioxidant, antithrombic, and vasodilatory effects.
There are six essential nutrients in our diet: carbohydrates, protein, fat, water, vitamins, and minerals. They are essential because they are needed for your body to function optimally. When you are deficient in any of these, there are negative health consequences. You also need the correct balance of these nutrients for ideal weight and health. The Mediterranean diet gets this right with a high amount of vitamins, minerals, essential fatty acids, and high-fiber sources of carbohydrates while it is low in processed foods.
Along with the essential nutrients are phytonutrients (also called phytochemicals). These are not considered essential because there is no deficiency if we don't have them in our diet. But they are very beneficial because having them in our diet enhances our health and helps fight diseases. Phytonutrients are found in plant foods and are there to protect the plants from germs, fungi, bugs, and other threats. There are over 25,000 phytonutrients and possibly more to be discovered. This is the reason you want to eat foods to get these instead of taking them in the form of a supplement. The Mediterranean diet is full of phytonutrients.
So, what does the Mediterranean diet have that other diets don't? Here are the sources of some of the health benefits:
There are two essential fatty acids in our diet; omega-3 (n-3) and omega-6 (n-6). Human beings' diets originally evolved with an equal ratio of n-3 to n-6. That means we consumed an equal amount of each. Over the years, the amount of n-6 in our diets went up to about 20 times the amount of n-3 that we consume. This is important to know because the benefits of n-3 are clear, and many people choose to take a supplement without realizing that not all essential fatty acids work the same or are needed from a supplement.
The research on the benefits of n-3 fatty acids has shown that it can help protect against inflammation, cardiovascular disease, hypertension, cancer, arthritis, depression, insulin resistance, obesity, and aging. The Mediterranean diet is high in n-3 food sources. These include salmon, anchovy, sardines, bluefish, herring, mackerel, mullet, sturgeon, and tuna.
Olives and olive oil
The phytonutrients found in olives and olive oil, known as phenolic antioxidants, are linked to neuroprotective effects against cerebral ischemia, spinal cord injury, Huntington's disease, Alzheimer's disease, multiple sclerosis, Parkinson's disease, aging, and peripheral neuropathy. Black olives and extra virgin olive oil have the highest content and need to be used in moderation to control the calories that you are getting from them.
Well-known legumes include green beans, peas, peanuts, soybeans, dry beans, chickpeas, lentils, alfalfa, clover, and broad beans. The majority of legumes contain phytonutrients that are linked to health benefits protecting against numerous diseases or disorders, including coronary heart disease, diabetes, high blood pressure, and inflammation.
Many people know how good garlic tastes but don't realize how good it is for you. The phytonutrient found in garlic, allicin, has turned out be helpful in acting as an antioxidant, an antimicrobial, for anticancer properties, and as a protectant against cardiovascular disease.
These flower buds from a shrub are used in the popular dishes chicken piccata, spaghetti puttanesca, and eggplant caponata. Few people realize the numerous health benefits of these little buds. Research has linked them to having antimicrobial, anti-oxidative, anti-inflammatory, immunomodulatory, anti-diabetic, anti-atherosclerosis, and antiviral properties.
This list goes on and on with all of the herbs, spices, and fresh foods that are consumed in the Mediterranean region. Getting to know the cuisine from the region can give you more ideas on what you can change in your diet.


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This addon disallows your users to post links in their posts & their signature.
In your acp options you can define the allowed urls.
If somebody tries now to post a link, he'll get a errormessage
[Extra] Block Links in Posts & Signatures (with Whitelist) 1.1.1
Block Links in Posts & Signatures
Recent Updates
- New Feature Release Jun 14, 2014
- New Feature Release May 31, 2014


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UPDATE 2-Exor to sell Cushman & Wakefield to DTZ in a $2 bln deal
* Exor's net proceeds at $1.28 bln, capital gain of $722 mln
* Proceeds will help Exor pay for any future acquisition
* Exor may consider raising PartnerRe offer, sources say (Adds details, PartnerRe, analysts, shares, edits throughout)
MILAN, May 11 (Reuters) - Italy's Agnelli family has agreed to sell real estate services group Cushman & Wakefield to DTZ in a deal that values the U.S.-based firm at around $2 billion.
Exor, the Agnellis' investment vehicle, said the sale of its 75-percent Cushman stake will generate net proceeds of $1.28 billion, representing a capital gain of $722 million.
The deal will give Exor additional firepower should it seek to raise its bid for Bermuda-based reinsurer PartnerRe.
The merger of Cushman with Chicago-based DTZ, owned by private equity group TPG, PAG Asia Capital and Ontario Teachers' Pension Plan, will create one of the world's largest real estate services companies, Exor said in a statement on Monday.
The proceeds will help Exor pay for any future acquisitions as it seeks to diversify a portfolio which also includes controlling stakes in carmaker Fiat Chrysler and tractor maker CNH Industrial.
Last month Exor made a $6.4 billion all-cash offer for PartnerRe to try to trump a bid by Axis Capital Holdings as it seeks to branch out into financial services with its steadier and higher returns. Continued...


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AKC PuppyFinder: Lagotto Romagnolo Puppies
- Breed Traits
- Personality: Easygoing, affectionate, and eager to please
- Energy Level: Somewhat Active; curious and upbeat, but not hyper
- Good with Children: Better with Supervision
- Good with other Dogs: Yes
- Shedding: Infrequent, Hypoallergenic
- Grooming: Occasional
- Trainability: Eager To Please
- Height: 17-19 inches (male), 16-18 inches (female)
- Weight: 28.5-35 pounds (male), 24-31 pounds (female)
- Life Expectancy: 15-17 years
- Barking Level: Barks When Necessary
- Breed Description
This ancient Italian breed may be the original water dog and is the only breed recognized as a specialized truffle finder. If you're not planning to search for truffles, the Lagotto Romagnolo can be an intelligent, affectionate companion. He doesn't ask for much, but does need lots of exercise, like a game of fetch or a swim. Your Lagotto Romagnolo puppy should be socialized early as he can be reserved with strangers. He's adaptable and rugged--a great match for an active family.
- History & Job
Origin: Italy
Year Recognized: 2015
Breed History & Job Description: Lagotti go back to at least Renaissance Italy, where they were bred as waterfowl retrievers working the marshlands of Ravenna. ("Lago" is Italian for "lake.") For many years, though, Lagotti, blessed with an exceptional nose, have been used in the Italian countryside to sniff out truffles, a tasty and expensive delicacy. Though many breeds can be trained on truffles, the Lagatto is generally considered the world's finest truffle dog.
- Health
Lagotto Romagnolos are generally a healthy breed. Like all breeds there may be some health issues. Some dogs may be faced with these health challenges in their lives, but the majority of Lagotto Romagnolos are healthy dogs.
Recommended Health Test from the National Breed Club:
- Hip Evaluation
- Ophthalmologist Evaluation
- Benign Familial Juvenile Epilepsy DNA Test
- Lagotto Storage Disease DNA Test
- Breed Club
- Breed Club: Lagotto Club of America
- Breed Club Link: http://www.lagottous.com/
- Breed Standard: View
- Group: Sporting
- 2016 Popularity: 114
- Rescue
- Breed Club Rescue: Lagotto Romagnolo Club of America
- Breed Club Rescue Email: email@example.com
- Breed Club Rescue Link: http://www.lagottous.com/page-18165


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Group Booking Terms and Conditions
Because you are making a Group Booking, there are additional Terms and Conditions that apply. Please read them and click 'I Accept' below to continue with your booking
General Group Booking Terms
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Hostel Specific Terms & Conditions
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Cancellation / No Show & Reduction in Numbers Policy
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최근 리뷰
" The staff here checks out on you on a regular basis if things are going good and try to give you good tips about Fez and other cities as well. Out of all the hostels I have visited, Veruz has the best breakfast. Common area is decorated with authentic moroccan stuffs which make you feel like your in a right place to stay. In Morocco, if you get any help on street, you will be charged for it, so the staff is the only reliable source you can get info without paying anything. Highly recommended! "- 익명
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호스텔월드 모바일앱으로 예약하세요.


text:
What we liked most about the Trump was the lack of any major inconveniences or drawbacks. The suite was nice and had a great view overlooking the strip. The bathroom was the most marvelous of a comparable size suite or room that we ever stayed at. There was a lot of storage space; there was a nice little kitchenette; none of the space was wasted on a mini-bar with insulting prices; 24 hour room service with excellent food; a 24 hour gym; and quite importantly...
... fast and reliable internet access.
Thankfully, all of the hotels we stayed at in Vegas this time - Trump, Vdara, and South Point - offered great internet access.
Now fast forward to our stay in Chicago. The most reasonable accommodation we could find was at a Residence Inn, where for a decent price, the little suite has nearly everything you might wish for - even a full fledged kitchen with a large fridge and a freezer - except...
... fast and reliable internet access.
About a week ago at South Point, I clocked the download speed at 2.3 megabytes per second. Here at Residence Inn, the "High Speed Internet" connection manages a paltry 60 kB/s, or about 2.5% of that.
At Vdara, the ping time to Google was consistently around 60-70 ms. Here, the ping time ranges anywhere from 300 to over 1000, with an average of over 500 ms. Even just pages with a lot of images take long to load, let alone more network intensive types of access.
I called the hotel's internet help desk, provided by Guest-Tek, to ask about these issues, and was shocked at their response. I thought perhaps there is a technical problem that makes the network temporarily that slow. But no. This is their service operating as intended. They consider the service to be primarily for business purposes such as email and basic web browsing. The following, they explicitly stated, are not what they consider acceptable uses:
- Watching streaming video (e.g. YouTube).
- Downloading music (e.g. from Amazon or iTunes).
- Skype.
If anyone knows of a place to stay in or around Chicago that offers (1) a fridge, (2) actual high speed internet access, and (3) a reasonable price...
... please leave a comment.
Edit: We made the mistake of giving a chance to another Marriott-operated Residence Inn in a different area near Chicago. They again advertised "free high-speed internet", and again, the problems were identical. The average ping time is 500-1000 ms, and the average transfer speed is 30-60 kB/s. A simple text page can take some 10 seconds to load. A page with photos takes minutes.
I am reporting these guys to the Federal Trade Commission - if I can get the page to load. :)


text:
Physiological β-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma
Cell differentiation and proliferation
A few reports suggested that low levels of Wnt signaling might drive cell reprogramming, but these studies could not establish a clear relationship between Wnt signaling and self-renewal networks. There are ongoing debates as to whether and how the Wnt/β-catenin signaling is involved in the control of pluripotency gene networks. Additionally, whether physiological β-catenin signaling generates stem-like cells through interactions with other pathways is as yet unclear. The nasopharyngeal carcinoma HONE1 cells have low expression of β-catenin and wild-type expression of
Introduction of increased β-catenin signaling, haploid expression of β-catenin under control by its natural regulators in transferred chromosome 3, resulted in activation of Wnt/β-catenin networks and dedifferentiation in HONE1 hybrid cell lines, but not in esophageal carcinoma SLMT1 hybrid cells that had high levels of endogenous β-catenin expression. HONE1 hybrid cells displayed stem cell-like properties, including enhancement of CD24+ and CD44+ populations and generation of spheres that were not observed in parental HONE1 cells. Signaling cascades were detected in HONE1 hybrid cells, including activation of
Wnt/β-catenin signaling regulates self-renewal networks and plays a central role in the control of pluripotency genes, tumor suppressive pathways and expression of cancer stem cell markers. This current study provides a novel platform to investigate the interaction of physiological Wnt/β-catenin signaling with stemness transition networks.
Multiple groups have shown that different dosage levels of Wnt signaling contribute to distinct cellular activities such as reprogramming, differentiation, tumorigenesis, and epithelial-mesenchymal transition (EMT) events
Nasopharyngeal carcinoma (NPC) is a unique cancer, which is particularly prevalent among the southern Chinese, but rare in most other areas around the world
We previously established several microcell hybrid cell (MCH) lines derived from HONE1 cells containing a transferred copy of chromosome 3
It is important to determine what critical role β-catenin plays in the transferred chromosome by examining the relevant network activities in recipient cells. It is well-accepted now that Wnt/β-catenin signaling interacts with many other signaling networks such as pluripotency, cadherins, EMT, transforming growth factor-β (TGF-β), fibroblast growth factor (FGF), and TSG signaling
Monochromosome 3 transfer confers physiological increases of β-catenin that up-regulates expression of core stem cell genes
We previously established several HONE1 hybrid cell lines that were confirmed to contain an exogenous copy of the intact chromosome 3, following fusion of parental HONE1 and mouse MCH903.1 donor cells
Figure 1
Exogenous β-catenin signaling induces Wnt pathway and stem cell-related network activities in HONE1 hybrid cells
Exogenous β-catenin signaling induces Wnt pathway and stem cell-related network activities in HONE1 hybrid cells. A. RT-PCR analyses for HONE1, MCH903.1, HONE1 hybrid cells (MCH4.4/4.5/4.6) and human embryonic stem cells H7. B. Immunofluorescence staining shows that β-catenin proteins clearly accumulate in the cellular membrane in most of hybrid cells (MCH4.6). C. Western blot analysis reveals that protein expression of β-catenin, Axin2, Nanog, Oct4 and E-cadherin is up-regulated in HONE1 hybrid cells, but N-cadherin is down-regulated. D. Luciferase assay shows increased Wnt activities in HONE1 hybrid cells. STOP/SFOP values are increased by 70-fold in MCH4.6 cells compared to parental HONE1 cells. E. Immunohistochemical staining shows consistent expression of Wnt target genes in mouse models. In tumor samples, protein expressions of β-catenin, E-cadherin, and Cyclin D1 are strongly up-regulated in tissues derived from two HONE1 hybrid cell lines (MCH4.5-1TS and MCH4.6-1TS), 40x magnification. Bars, 20 μm. F. RT-PCR analysis shows that loss of transferred chromosome fragment containing an exogenous β-catenin copy (MCH4.5-2TS) is associated with concomitant loss of up-regulated expression of endogenous genes.
Significant expression of pluripotency genes,
The increased level of β-catenin protein accumulating around membranes was clearly detected in the majority of hybrid cells compared to parental HONE1 cells by immunofluorescence staining (Figure
Enhanced Wnt/TCF/LEF network activity is maintained
A luciferase assay was performed using a Wnt/TCF reporter plasmid that carries a large array of Wnt response elements and is, therefore, a sensitive reporter of Wnt signals. As shown in Figure
Immunohistochemical staining of the xenograft tumors demonstrated that β-catenin, E-cadherin
It has long been known that some regions of transferred chromosomes in TSs are selectively lost during tumor growth and the expression of relevant exogenous genes reverts back to levels similar to parental HONE1 cells
Physiological expression of exogenous β-catenin is essential for the up-regulation of the endogenous core stem cell network
To further confirm whether expression of exogenous β-catenin is a major determinant in the regulation of the core stem cell network in HONE1 hybrid cells, we performed inhibitory assays using short hairpin RNAs (shRNAs) that silence β-catenin expression in infected cells. A scrambled shRNA was used as a negative control in all experiments. HONE1 hybrid cells with infected scramble shRNA have up-regulated expression of β-catenin compared to parental HONE1 cell (Top panel, Figure
Figure 2
shRNA knockdown of β-catenin is associated with the regulation of Wnt pathway, EMT, and pluripotency networks
shRNA knockdown of β-catenin is associated with the regulation of Wnt pathway, EMT, and pluripotency networks. A. The top panel shows that HONE1 hybrid cells have an up-regulated expression of β-catenin by qPCR analyses, compared to the parental HONE1 cells. MCHs 4.5 and 4.6 are infected by scramble (empty bars) and β-catenin shRNAs (black bars). The number in parenthesis refers to the growth passages of cells after infection. Fold-changes reflect inhibitory expression of β-catenin in these cells compared to corresponding scramble negative controls. β-catenin expression is reduced in all four cell lines, as shown in the bottom panel. B. qPCR analyses show inhibited expression of
HONE1 hybrid cells are poorly differentiated and exhibit stem cell-like properties
Parental HONE1 cells grow as monolayers that do not form spheres under ordinary culture conditions, evidenced by our long-term culture of these cells
Figure 3
HONE1 hybrid cells have properties of stem-like cells
HONE1 hybrid cells have properties of stem-like cells. A. Phase-contrast images of spheres that could be grown on the surface of monolayer epithelial cells or bottom of flask (upper right and upper left). The bottom picture shows image of parental HONE1 cell growth. The bar graph indicates that parental HONE1 cells and HONE1 hybrid cells with infected β-catenin shRNA (Hybrid/shB) do not form spheres in the same culture conditions. B. FACS analyses (bar chart, Left) show that HONE1 hybrid cells (solid bars) contain more CD24+, CD44+, CD24+/CD44+ populations than those of HONE1 cells (empty bars). The figure (right) shows that hybrid cells have increased numbers of double positive CD24+/CD44+ populations.
Since CSC markers, CD24 and CD44, are commonly expressed in many stem-like cells, we investigated expression changes of these two markers by FACS analysis. CD24+, CD44+, and CD24+/CD44+ populations were markedly increased from 23% to 53.2%, 35.7% to 77.9%, and 42.7% to 77.2%, respectively, in HONE1 hybrid cells compared to parental HONE1 cells (Figure
Physiological Wnt levels trigger multiple signaling activities during the regulation of stem cell gene networks
The qPCR array results confirmed that pluripotency genes,
Figure 4
Physiological β-catenin signaling triggers multiple signaling pathways in HONE1 hybrid cells, and BIO-induced Wnt signaling activities in HONE1 cells
Physiological β-catenin signaling triggers multiple signaling pathways in HONE1 hybrid cells, and BIO-induced Wnt signaling activities in HONE1 cells. A. Stem Cell Transcription Factors Array shows major transcription factors that are up-regulated in HONE1 hybrid cells. B. The bottom panel demonstrates Stem Cell Signaling Array, showing that four signaling pathways are activated in HONE1 hybrid cells. C. RT-PCR analyses show that both β-catenin and
The exogenous copy of β-catenin in HONE1 hybrid cells induced signaling cascades involved in multiple pathways such as Wnt, TGF-β superfamily containing
Additional file 1
Table S1. Expression changes in HONE1 hybrid Cells (compared to parental HONE1 cells) assayed by Stem Cell Signaling PCR Array. Table S2. Primers used in RT-PCR and qPCR analyses. Table S3. Antibodies used.
Click here for file
BIO activation of Wnt signaling generates similar signaling activities as induced by chromosome 3 transfer in HONE1 cells
The GSK-3-specific inhibitor, Bromoindirubin-3'-oxime (BIO), activates Wnt signaling in stem cells and somatic cells
To verify the critical role that physiological signaling levels exert, BIO treatment was used to generate high, non-physiological levels of β-catenin protein expression in cells. Western blot analyses indicated that β-catenin, Axin2, and E-cadherin were strongly up-regulated in BIO-treated HONE1 cells. These results were also confirmed in MCH4.5-2TS cells that lost a transferred copy of
Figure 5
The high levels of β-catenin signaling do not up-regulate Nanog and Oct4 expression in both HONE1 and SLMT1 cells
The high levels of β-catenin signaling do not up-regulate Nanog and Oct4 expression in both HONE1 and SLMT1 cells. A. Western blotting shows that both concentrations of 5 μM and 10 μM BIO treatment induce strong over-expression of β-catenin in treated cells, but 10 μM BIO treatment causes strong cytotoxic effects in cells and possible reduced expression of Axin2 in HONE1 cells. Compared to mock-treated HONE1 and MCH4.5-2TS cells, no obvious up-regulation of both Nanog and Oct4 expression is detected in β-catenin over-expressing cells, but E-cadherin is clearly up-regulated in both BIO-treated cell lines. B. SLMT1 cells have high levels of expression of β-catenin and do not respond to exogenous β-catenin signaling. RT-PCR analysis shows that HONE1 hybrid cells have an up-regulated expression of β-catenin and
Chromosome 3 transfer does not affect cells with high levels of endogenous β-catenin expression
To determine whether physiological β-catenin signaling might regulate other human cells, esophageal carcinoma SLMT1 cells were examined
Tumor suppressor gene-mediated pathways are activated in HONE1 hybrid cells
Because the tumor suppressor
Figure 6
The exogenous β-catenin signaling induces an up-regulation of
The exogenous β-catenin signaling induces an up-regulation of
Since tumor suppression pathways were activated in HONE1 hybrid cells due to the up-regulation of Wnt/β-catenin signaling, it may affect growth ability of cells. To test these possibilities, MTT and colony formation assays in matrigel were performed with both stable scramble and β-catenin shRNA-infected HONE1 hybrid cells. The results indicated that tumor cell growth was inhibited by the knockdown of Wnt/β-catenin signaling in these cells (Figures
Wnt signaling and stemness network activities are progressively up-regulated in sphere-forming cells
In the dedifferentiation progression of HONE1 to hybrid to sphere cells, RNA expression of four core stem cell genes,
Figure 7
Analyses of spheres derived from HONE1 hybrid cells
Analyses of spheres derived from HONE1 hybrid cells. A. RT-PCR analyses show that the expression of genes that encode CSC markers, CD9, CD24, CD44, CD90, and CD133, in sphere-forming cells (spheres A, B, and C) are progressively up-regulated compared to HONE1 and HONE1 hybrid cells. B. and C. Wnt Signaling Pathway qPCR Array assay lists the 34 up-regulated genes and 12 down-regulated genes in spheres, compared to HONE1 hybrid MCH4.4.
Consistent with findings obtained from Stem Cell Signaling Array analysis (Figure
Wnt signaling plays a substantial role in the control of development of several types of tissues through a dosage-dependent fashion. These regulated cells include crypt progenitor
Consistent with findings of both components of Wnt pathways and the core stem cell network being expressed or up-regulated in HONE1 hybrid cells, we found that the Wnt signal was clearly increased in HONE1 hybrid cells, as compared with untreated HONE1 cells. These
To exclude the possibility that genes other than
Both chromosome 3 transfer and BIO treatment in HONE1 cells regulated EMT genes or its regulators. However, BIO only had similar, not identical biological effects as the chromosome 3 transfer, as evident in the control of cadherin switching. The Wnt signal controlling these EMT and cadherin networks was evidenced by the fact that β-catenin protein accumulated at the membranes, as seen in BIO-treated cells, hybrids with transferred chromosome 3, and recent stemness studies
The qPCR Array results confirmed that physiological β-catenin signaling triggered signals through additional pathways including pluripotency maintenance, FGF, and TGF-β superfamily signaling in HONE1 hybrid cells. For example, Smad2/5/9 and TGF-β receptors were clearly activated, which confirms previous reports that the TGF-β signaling pathway is associated with the pluripotency gene network and the EMT process
The stemness transition of HONE1 cells, driven by physiological Wnt/β-catenin signaling, appears to be a progressive process leading to a de-differentiated state in spheres, as demonstrated by analysis of up-regulated expression of core stem cell genes. Furthermore, genes that encode surface markers, such as CD9, CD24, CD44, CD90, and CD133, in spheres were expressed or clearly up-regulated compared to hybrid cells. Many Wnt signaling components in sphere-forming cells were identified as being involved in this stemness transition process, compared to hybrid cells. More than two-fold up-regulation of expression was detected in 34 genes
These studies demonstrate that both dosage levels of β-catenin signaling and genetic background of tissues play critical roles in the regulation of self-renewal networks in human cells. There are very limited methods to explore physiological levels of Wnt/β-catenin signaling in current biology studies and the results of these studies indicate that haploid levels of expression of transferred β-catenin can induce signaling cascades that include multiple known pathways associated with reprogramming and self-renewal processes. Appropriate Wnt signaling may drive cancer cells into a progressive de-differentiated state, which generates expression profiles for exposure of the regulatory mechanism in stemness transition. These novel results clarify the relationships that are still controversial and rather unclear at present among Wnt signaling, stemness networks, EMT events, TSG pathways and expression of common cancer stem cell surface markers. These findings shed new light on a variety of cellular processes never before associated with physiological levels of β-catenin signaling that provide a framework for future studies to define the molecular mechanisms governing cell fate determination in human cells.
Cell lines and culture conditions
NPC HONE1 cells
BIO treatment
BIO (Stemgent, San Diego, USA) was stored and diluted following manufacturer's instructions. Cells were grown in T25 flasks to 50% confluence and treated with BIO at concentrations of 0.5 μM, 1.0 μM, 2.5 μM, 5 μM, 10 μM, and 20 μM. Twenty-four hours later, both BIO-treated and mock-treated cells were washed in PBS and harvested for total RNA extraction.
Sphere formation assay
HONE1, HONE1 hybrids, and HONE hybrids with infected β-catenin shRNA cells were plated in T25 flasks, coated with 0.1% gelatin at 10–30 viable cells/ml and grown in Dulbecco's modified eagle medium (DMEM) supplemented with 10% FBS. Cells were allowed to grow until spheres appeared. Three independent experiments were performed. After spheres formed, non-spheroid cells surrounding the spheres were scratched off and washed away with PBS daily in order to maintain the sphere growth. Only 50% of the culture medium was changed each time. The number of spheres was recorded under microscopy from 45 to 90 days after seeding cells. The pooled large and small spheres were collected for further RNA analysis.
RT2 Profiler PCR array analysis
Stem Cell Transcription Factors, Stem Cell Signaling, and Wnt Signaling Pathway PCR Arrays were obtained from SABIOSCIENCES (
Infection of shRNAs
Both shRNAs scramble
Luciferase assay
HONE1 and HONE1 hybrid cells were transiently transfected using 1 μg of luciferase reporter plasmids (STOP) and control plasmids (SFOP) with the Lipofectamine 2000 (Invitrogen) transfection reagent according to manufacturer's instructions. Cells were collected and lysed 48 hours post-transfection. The luciferase activity was assayed using the Luciferase Assay System (Promega). The β-galactosidase activity was assayed using Galacto-Light Plus System (Applied Biosystems, Life Technologies, Carlsbad, CA, USA). Both luciferase and β-galactosidase activities were measured using a TD20/20 luminometer (Turner Biosystems). STOP/SFOP ratio of luciferase reporter activities was normalized using β-galactosidase activities
RT-PCR and qPCR analyses
Total RNA was extracted using TRIzol reagent (Invitrogen, Carlsbad, CA, USA). One microgram of total RNA was reverse-transcribed with M-MLV Reverse Transcriptase (USB, Cleveland, OH, USA), as previously described
Flow cytometry
Antibodies against CD24 and CD44 (BD Pharmingen) were used for FACS analyses. To sort HONE1 and HONE1 hybrid cells, the collected cells were resuspended in Pharmingen Stain Buffer and stained with antibodies for 30 min. The antibody-positive cells were sorted by the BD FACSAria Cell Sorter (San Jose, CA, USA), according to the protocols provided by the manufacturer.
Cell proliferation assay
The cell proliferation ability was studied using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay. Briefly, 0.5 × 103, 2.0 × 103, and 4.0 × 103 cells were seeded in 96-well plate. The cell proliferation rate was measured consecutively for 5 days. Thirty μl of 5 mg/ml filtered MTT solution (Sigma Chemical Co., St. Louis, MO) was added into the cells and incubated at 37°C for 4 hours. The absorbance at 570 nm was recorded with Multiskan FC Microplate Photometer (Thermo Scientific Inc., MA, USA).
Three-dimensional matrigel colony formation assays
A total of 1,000 cells was seeded on the top of Matrigel (BD Biosciences) and cultured for 14 days in 96-well plate. Images were captured at 4x and 10x magnification using Nikon Eclipse Ti inverted microscope (Nikon Instruments Inc., NY, USA) and analyzed with SPOT Advanced software (Diagnostic Instruments Inc., MI, USA). Colonies in 3 fields at 10x magnifications were counted and reported as the average number of colonies on the day 7 and 14.
Western blotting and immunofluorescence staining
Cells were seeded onto a 150 mm culture plate and were then scraped from the plate for Western blotting, which were performed as previously described
Animal assay and immunohistochemical staining
Both HONE1 and HONE1 hybrid cells were injected into nude mice as previously described
BIO: Bromoindirubin-3'-oxime; CSC: Cancer stem cells; DMEM: Dulbecco's modified eagle medium; EMT: Epithelial-mesenchymal transition; FGF: Fibroblast growth factor; MHC: Microcell hybrid cell; MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide; NPC: Nasopharyngeal carcinoma; ShRNA: Short hairpin RNA; TGF-β: Transforming growth factor-β; TS: Tumor segregants; TSG: Tumor suppressor gene.
Competing interest
The authors declare that they have no competing interest.
Authors' contributions
YC designed research. YC performed molecular, cell culture and animal studies. AKLC, JMYK and YPP carried out Western and immunofluorescence staining. YPP and YC performed Luciferase, qPCR array and
The authors thank Dr. Eric Stanbridge (University of California, Irvine) for helpful discussion and material support. The authors also thank Drs. David Sabatini and William Hahn for shRNAs from Addgene, the University of Hong Kong Li Ka Shing Faculty of Medicine Stem Cell Core Facility for stem cells, equipment access in the Core Facility for microscopy and FACS analyses, and the Department of Anatomy for access to the TD20/20 luminometer. This work was funded by the Research Grants Council Area of Excellence scheme in Hong Kong (AoE/M-06/08) to MLL and the University of Hong Kong Seed Funding Program for Basic Research (Project Codes: 201007159005 and 201111159142) to YC.
Wnt/beta-catenin signaling in cancer stemness and malignant behavior
Selective activation mechanisms of Wnt signaling pathways
Wnt signalling in stem cells and cancer
Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells
Defining the role of Wnt/beta-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cells
Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
Wnt/beta-catenin signaling and disease
WNTing embryonic stem cells
Wnt/beta-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4
Functional evidence for a nasopharyngeal carcinoma tumor suppressor gene that maps at chromosome 3p21.3
A functional investigation of tumor suppressor gene activities in a nasopharyngeal carcinoma cell line HONE1 using a monochromosome transfer approach
An infrequent point mutation of the p53 gene in human nasopharyngeal carcinoma
Nasopharyngeal carcinoma shows no detectable retinoblastoma susceptibility gene alterations
Suppression of induced pluripotent stem cell generation by the p53-p21 pathway
Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle
Mechanisms of stem cell self-renewal
Excess beta-catenin promotes accumulation of transcriptionally active p53
p53 and microRNA-34 are suppressors of canonical Wnt signaling
A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells
Differential requirement for the dual functions of beta-catenin in embryonic stem cell self-renewal and germ layer formation
Maintaining embryonic stem cell pluripotency with Wnt signaling
Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation
Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal
Develop-WNTs in somatic cell reprogramming
WNT signaling pathway and stem cell signaling network
Periodic activation of Wnt/beta-catenin signaling enhances somatic cell reprogramming mediated by cell fusion
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
E-cadherin-mediated cell-cell contact is critical for induced pluripotent stem cell generation
Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast
Embryonic stem cell lines derived from human blastocysts
Mapping of nasopharyngeal carcinoma tumor-suppressive activity to a 1.8-megabase region of chromosome band 11q13
Deciphering the molecular genetic basis of NPC through functional approaches
Monochromosome transfer provides functional evidence for growth-suppressive genes on chromosome 14 in nasopharyngeal carcinoma
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
Identification of a tumor suppressive critical region mapping to 3p14.2 in esophageal squamous cell carcinoma and studies of a candidate tumor suppressor gene, ADAMTS9
Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB
Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells
Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion
Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer prrx1
A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts
Abrogation of E-cadherin-mediated cell-cell contact in mouse embryonic stem cells results in reversible LIF-independent self-renewal
Roles of tumor suppressor signaling on reprogramming and stemness transition in somatic cells
Two epithelial tumor cell lines (HNE-1 and HONE-1) latently infected with Epstein-Barr virus that were derived from nasopharyngeal carcinomas
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity
A unique DNA binding domain converts T-cell factors into strong Wnt effectors
Diversity of LEF/TCF action in development and disease
Chromosome 14 transfer and functional studies identify a candidate tumor suppressor gene, mirror image polydactyly 1, in nasopharyngeal carcinoma