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text: Errors delay Mladic war crimes trial Add to ... AP Video Published Thursday, May 17, 2012 1:38PM EDT Last updated Thursday, May 17, 2012 1:38PM EDT The presiding judge has ruled that the trial of Ratko Mladic on genocide and war crimes charges will be delayed because of prosecutors' errors regarding the disclosure of evidence. Watch More Video: Uncertainty looms in Europe after Brexit vote Obama: Brexit will not change the 'special relationship' between U.S. and U.K. Doug Saunders: It will take a decade to repair the relations Britain just severed Officer shot multiple times near Philadelphia Toronto officials make decision on controversial Swansea treehouse Bipartisan House gun legislation announced in U.S. Trudeau: 'We respect the choice of the British people' U.K. falling apart? New Scottish referendum 'likely' after Brexit vote Brexit: Easier said than done Bernie Sanders says he will vote for Hillary Clinton Trump: Brexit vote is 'will of the people, embrace it' Brexit vote highlights deep divides in UK 'It's a great thing': Trump praises Brexit vote 'Brexit' wins key EU membership referendum EU chief: 'What doesn't kill you makes you stronger' 'Leave' campaigner celebrates win in Brexit referendum British Prime Minister Resigns Britain votes to leave European Union Amnesty International calls on Trudeau to press Mexican president on human rights Jury: Led Zeppelin didn't steal riff Comments AA Follow us on Twitter: @globeandmail

subset: commoncrawl


text:
Photo SpecialAnd ... Action! Go Inside the Toronto International Film Festival
Jennifer Aniston! Scarlett Johansson & Joseph Gordon-Levitt! Olivia Wilde! See what happens when Hollywood heads north
Credit: Michael Buckner/Getty
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Get Your Gay Access Now!
Category Bareback
Added August 18, 2013
Viewed 11,792 times
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Duration 18m, 31s
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Martin and Mila went out for a hike this afternoon and came back changed men. They had been buds for a long time and each had feelings for the other but was always afraid of showing them. Something about the warm afternoon sun and the tranquil surroundings got them over the emotional hump. When they found out their attraction was mutual it quickly became hard to tell which of them was more excited about the prospect of getting off on one another!
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StartUpHire is the place to find Engineering jobs in and near Plymouth. Review the list below of Engineering Plymouth jobs. These Engineering jobs represent some of the most rewarding careers available. You can refine your job search for Engineering jobs in Plymouth by adding a job title, company name, or keyword to the search box above … or click the "Advanced Search" link for more options. Don't see the employment opportunity you're looking for? Check back soon for more Engineering jobs in Plymouth, or sign up for an email alert (link in upper left) to receive periodic updates on new Engineering jobs in Plymouth, MA.
? Location: Waltham ? Department: Products/Services Job Description: Overview Provides technical expertise in NoSQL data modeling and relational data modeling, as well as implementation of such models at both logical and physical level using data modeling tools. Develops,6/23/2016 Waltham, MA Save This Job
? Location: Waltham, MA, United States ? Department: Products/Services Job Description: Release Manager (Intralinks, Inc.; Waltham, Massachusetts): Intralinks is a leading worldwide provider of Cloud based extended enterprise collaboration solutions. Our products are used by6/23/2016 Waltham, MA Save This Job
Senior Solutions Engineer - Eastern Region (Boston, New York, Virginia etc...) Sales Tysons Corner, VA, United States Apply Send Jobvite The Ayla Platform? is the industry?s only complete end-to-end solution for transforming everyday products into cloud-connected devices6/22/2016 Boston, MA Save This Job
Clinical Operations Cambridge, MA, United States Merrimack is a fully integrated biopharmaceutical company that views cancer as a complex engineering challenge. Through systems biology, which brings together the fields of biology, computing and engineering, Merrimack aims to6/21/2016 Cambridge, MA Save This Job
Boston, Massachusetts ApplyApply with LinkedIn Job Responsibilities: ESSENTIAL DUTIES AND RESPONSIBILITIES include the following. Other duties may be assigned. The Localization Engineer is responsible for technical production of localization and translation projects on multiple6/15/2016 Boston, MA Save This Job
We are seeking a versatile Senior Mechanical engineer to join our engineering team in Watertown, MA. The successful candidate will focus on performing theoretical and FEA analysis for thermal and structural studies. S/he must have the ability to calculate and predict forces,6/14/2016 Watertown, MA Save This Job
Recommind builds breakthrough software solutions that harness the power of information to solve concrete business problems. Our patented innovations at the nexus of law, big data, and predictive analytics help extract critical insights from massive volumes of unstructured data -6/14/2016 Norwood, MA Save This Job
Location Burlington, MA Data Quality Engineer The Data Quality Engineer is responsible for creating and maintaining test plans and test cases, executing formal test plans, and implementing API based regression and performance tests. This position reports to the VP Engineering -6/2/2016 Burlington, MA Save This Job
Operations Boston, MA, United States Today, Zipcar provides hundreds of thousands of people with a viable alternative to traditional car ownership, saving them money, time and headaches. Around the world?from coast to coast, across Canada, the United Kingdom, Spain, Austria,6/2/2016 Boston, MA Save This Job
Location: Cambridge, MA Founded by pioneering scientists in fabrication, genetics, and bio-engineering, the Gen9 vision is one of democratizing synthetic biology. Our goal is to enable broad adoption of powerful synthetic biology techniques by providing custom DNA constructs6/2/2016 Cambridge, MA Save This Job
Tracking Code 244-093 Job Description The purpose of the Field Engineer (FE) is to provide: technical oversight of the products? installation environment, maintenance of the system to ensure reliable performance, solution-oriented consultative training, technical support, and5/31/2016 Boston, MA Save This Job
Tracking Code 263-093 Job Description We are seeking a talented and highly motivated individual to join our team as a Software QA Engineer - Contract. This position will report directly to the Director, Software Engineering. T2 Biosystems uses Agile and Extreme Programming (XP)5/31/2016 Lexington, MA Save This Job
Cambridge, Massachusetts Job Description The health care system doesn't work for patients. But you can help change that. PatientsLikeMe is leading the social medicine space by focusing on the sharing of real-world data. If you want to work with great people for a well-funded5/31/2016 Cambridge, MA Save This Job
Tracking Code 210-093 Job Description We are seeking a talented and highly motivated individual to join our team as a Quality Assurance Engineer. Summary Responsible for supporting the quality assurance department promoting product quality and quality system compliance consistent5/31/2016 Lexington, MA Save This Job
About the Job We are currently seeking an energy efficiency project manager to join the Utility Services group in our Burlington, MA office. The successful candidate will be responsible for managing demand side management programs for commercial, industrial, and utility clients.5/30/2016 Burlington, MA Save This Job
US-MA-Boston Apply View All Jobs Share This Job About Bullhorn We build applications that help businesses deliver an incredible customer experience. Headquartered in Boston with offices in London, Sydney, St. Louis, and Vancouver, Bullhorn is the global leader in CRM5/30/2016 Boston, MA Save This Job
Job Description Director of Product Management - (02152) Description Summary: Gemalto?s Software Monetization business unit is looking to add to our Product Management team a strategic market-facing PM to take ownership for promoting and driving our strategy for the Sentinel5/29/2016 Boston, MA Save This Job
Department:Engineering Location:Boston, MA Click Here to Complete Your Application Who we are: Advanced Practice Strategies ?APS? is a technology company committed to helping clinicians achieve their highest potential. We?re fast growing, venture-backed and work with some of the5/29/2016 Boston, MA Save This Job
Information Technology Cambridge, Massachusetts Apply Who We Are Good Start Genetics is a molecular genetics information company transforming the standard of care in reproductive medicine. Its suite of reproductive genetics products provides clinicians and patients with5/27/2016 Cambridge, MA Save This Job
Information Technology Cambridge, Massachusetts Apply Good Start Genetics is a molecular genetics information company transforming the standard of care in reproductive medicine. Its suite of reproductive genetics products provides clinicians and patients with insightful and5/27/2016 Cambridge, MA Save This Job


text:
Great job! It's been a while since I've played a classic Pokémon game so I need some getting use to. Two questions:
1) Does the 2nd gen patch also work on the 15 generation IV PKMN from Brown so you could have the total of 266 Pokémon?
2) If we need to re-patch, can you patch it again with the pre-patched rom or do I patch a fresher Red Version?


text:
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Training InstituteThe training institutes directory provides information on the leading education training institutes of India. Get extensive details on education institutes in India providing training facilities in various fields such as computers, human resources, information technology, media, etc. View online website listing of popular training institutes of India and browse these websites to get important information such as course details, fee structure, admission procedure and contact details from this vast training institute web guide of India.
Latest Website Listings
- Institution of Industrial Safety Professionals of India. Several leading Professionals from the field of Industrial Safety promoted the national body of Safety Professionals during the year 1977 and named it the "Institution of Industrial Safety Professionals of India" with their headquarters at Bombay. The Institution was formally inaugurated on the 19th August, 1978.
- 1st Academy of Security Science Education & Training Pvt. Ltd. 1st Academy is one of the pioneers of Security Education and Training in India. It provides expert tuition, vocational training, and qualifications. In this role 1st ASSET works in partnership with key industry representatives to define and meet current and future training needs within the industry.
- Frameboxx Animation Visual Effects Pvt. Ltd. Frameboxx Animation & Visual Effects is a versatile conglomerate with a focus on providing world class Animation, Media & Visual Effects training. Founded by a team of industry professionals with over ten years of experience in Animation Production and Education, Frameboxx is a pioneer in providing highly innovative and quality training services over a range of verticals with Classroom Training being the primary domain of operations.
- Jetking Infotrain Ltd. Jetking Infotrain Ltd., Indias No. 1 Computer Hardware, Networking and Cyber Technology Institute, is a pioneer in IT education in India, with 60 years experience in Training Industry.Today we are the acknowledged market leader in training in Computer Hardware and Networking Technologies, having trained more than 2,00,000 students through our network of 110 highly successful centers across the country.
- Teachers Training Courses in Delhi INDOSS Polytechnic for women is the premier teacher training institute offering, nursery/primary teacher training, for aspiring teachers and Montessori school administrators. The courseware has been developed by senior montessorians and the Montessori course has proven to be comprehensive for the pre-school level, to anyone who wants to become teacher. We offer full-time, part-time and distance learning courses with contact programs and practical workshops.
- IEC Education Ltd. IEC is one of the premium Computer Training Institutes in the country which has grown immensely from a humble beginning to an established brand in providing quality education. India Education Centre was an Association of Persons run and managed by Gupta Enterprises, a registered private family trust established on 16th October, 1981 with Mr R.L Gupta and family.
- Sri Sarada Math Rasik Bhita Rasik Bhita - Shiksha O Sanskriti Peetha, is the educational and cultural welfare centre of Sri Sarada Math, Dakshineswar, Kolkata. Started on January, 2002, it has opened the doors to Information Technology, Communication through English and Soft Skill mainly for the underprivileged girls of the surroundings.
- Cynix Technologies Online IT Guru Services Welcomes you in the world of E-Learning, where we provide a single point of accessibility for your learning need. Over the last two years Online IT Guru Services is has fulfill the needs of many individual and companies in various software technologies.
- Eagle Academy Col Prakash Khandekar completed his ISC 12th from Mount St.Marys , New Delhi in 1971 and joined the 46th Course NDA as Army Cadet in June 1971 . He graduated as Cadet Sergeant Major CSM of LIMA Squadron in 1974 after obtaining B.Sc.degree from JNU.He joined the Indian Military Academy, Dehradun - June 1974 and was commissioned on 15 Jun 1975 into the Corps of Electrical & Mechanical Engineering EME also known as The EAGLES as a Second-Lieutenant 2/Lt.
- PARIKSHAN Prashikshan Kendra Pvt. Ltd. formerly known as the IITians Pratishthan is a premier institute for IIT-JEE and allied competitive exams training in Maharashtra. The institute offers classroom and postal courses for competitive exams from Std. VIII - XII. The IITians Prashikshan Kendra has the track record of producing the maximum number of IIT selections from Pune city for five consecutive years.
- Brilliant Institute We provide proper counseling to choose proper career and this facility is provided without any extra charge. Later it helps the students to build their career in a better way. Information and counseling for helping in choosing their career, courses, subjects and other ancillary matters e.g. where to study, when to take admission, its expenses and ways to get admission, all information is provided by us.
- U TURN Training & Consultancy U TURN Training & Consultancy is an emerging firm in the field of training and counseling and aims at providing value-added services to its clients. Our aim is to provide effective training and counseling services to our corporate clients leading to a highly motivated and an effective and efficient workforce, which is a great asset to an organization.
- Indian Institute of HARMONICA We have successful rate astonishing and results show that 97% of our students play the harmonica with great ease at the end of their term. In fact we provides every fresh student plays his first tunes right from the first session and all plays a number of songs at the end of two/three months. Also we'll like to add here that it is not at all difficult to learn. So instead of spending time in reading the tabs one should try to learn the standard notation, either sol-fa or staff.
- WisdomHall WisdomHall is an educational and training facility for Professional Skills Building. It is promoted with a purpose to provide well rounded development of the Students who wish to prepare themselves for the modern corporate culture and to meet the requirements of Corporate Sector. Our aim is to groom the youth of today for better personality, working ethics, knowledge and experience that will put them ahead in the competitive corporation for various job position available in the market.
- Avesthagen Clinical Research and CDM Training Avesthagen Clinical Research and CDM Training with Job Placement We are providing Advanced PG Diploma in Clinical Research, ICH GCP, Pharmacovigilance, Regulatory and Clinical Data Management ( SAS Clinical, Oracle Clinical Programming and Pharmacovigilance Software )Training with internship and Job Placement. Contact : Dr.Shaw Mobile : 09886735658
- CAD ZONE CAD ZONE has been established with an aim to provide software training, services in the field of Mechanical, Architectural/Civil, Electrical, Interior Designing and Project Management with the help of high end software like Auto CAD, Solidworks, CATIA, Unigraphics, STAAD, REVIT and Primavera etc. CAD ZONE is backed by high profile and experienced manpower to provide software training and product development.
- Faith Institutions Our Institution was started in year 2003 � 2004 under the able excellent and experienced management and Educational Charitable Trust. We have minority institution that provides University Education atmosphere for deserving students irrespective of caste and creed. Our college is committed as the economically weak, socially backward and needy students.
- Maharashtra Institute Of Printing Technology Pune Vidyarthi Griha has many activities like Sadachar Vasati Griha, English and Marathi Medium Schools / Junior Colleges at Pune, Mumbai and Nasik. Engineering College and Polytechnic at Pune. It is situated at the heart of the city at Sadashiv Peth and therefore is easily accessible. Bus Stands, Railway Stations, Hostels, Markets, Hospitals all are very close to Pune Vidyarthi Griha.
- SGK India Industrial Services P Ltd. At the outset, we would like to introduce ourselves as SGK India Industrial Services Pvt. Ltd. an ISO 9001:2008 Certified Company. We are constantly evolving research fields into the development of our recruitment, outsourcing and training Programs. We can maintain all employees record like compliance issues, statutory parts, Labour laws etc. And all the responsibilities, risks are under our scope.
- System Administration Support Services, DADA INTERNATIONAL is a global Information Technology company which provides Information Technology Support Services in field of System Administration, System Architect, Datacenter Support, Business Continuity, Disaster Recovery, Storage, Backup and Virtualization. Services we provide System Administrator We provide Linux and Solaris System Administration support for US companies. We can work during US hours. We work 24/7. The support includes: * Remote system administration using authenticated and encrypted connections * Automated service monitoring and alerts * Storage Administration * Virtualizaton Support * System Architecture * Software Upgrades * Disaster Recovery Setup * Backup Maintenance * Server Setups * Capacity Planning * Script Writing for Automation
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text:
ExtraOrdinary Part 2 is HERE. Available on USB cassette & Digital DL
Extraordinary Part 2. It's here. right now.
Extraordinary Part 2. It's here. right now.
TOMORROW Sat 9/12 – some #NYC heads controlling the music at Kinfolk 94 in BK . DJ Soul, Max Glazer and yours truly.
TONITE – Sept 4th w/ DJ Delve & DJ SSSolution at Addiction in Honolulu HI for ColorWaveHIFI
Today 8/22 Sat , I'll be providing the soundtrack at 136 wooster while ya shop…
A few years ago I had a summer residency at Brooklyn Bowl.
I'm back for one night only – August 7th Friday.
TODAY – July 29th from 6-8 come join us in Freehold NJ for a sneak peak of the new adidas store!
july 25th – A REALLY KOOL PARTY – Official Sneaker Summit Pre-Party
H-Town Sneaker Summit is the destination for this weekend… 7/25- 7/26 at the NRG Center.
Join us today at 7/22 from 1-3pm at adidas Sports Performance Store – 610 Broadway NYC for the Chelsea Football Club Jersey Launch
Watch some of New York's hottest young soccer talent battle it out in an adidas 2 v 2 soccer tournament at FC Harlem's Training Ground on Tuesday July 21st!
6/26 – I'm holding down the turntables for this invite only event. Hoping ya got the invite! I'm on the wheels from 8-9:30 Tonite 6/26 Friday.
I'm in LA to do a little talk at the #powwowlongbeach school of music, so I figured we could take it a step further and do a special #dinnerandamixtape , joining the love of Music & Art with the love of good food.
Hella DJ's Bdays at Lock & Key LA
Ya'll know I love food, so we're gonna do a food related bday event with the homies over at Ain't 2 Proud 2 Brunch.
Another year living, another year to come celebrate with me .
Nice interview about my love of Food, Music, Travel & my pooch Poh the dog on The Hundreds …
You are invited to the 2015 Young Lions Ficion Award Benefit:
celebrating the 15th Anniversary of the Fiction award and honoring the works of today's best young writers with Fiction Award Co-Founder Ethan Hawke
4/11 – Saturday – The Final Stop on the Dinner & A Mixtape Roadtrip in Austin Texas, at Jenna's Asian Kitchen.
4/7 TONITE – Joining the party peoples for Tuesday Blend at Hard Rock Live
Dinner & A Mixtape Roadtrip rolls on, April 5th – Sunday Dinner & A Mixtape w/ Kaba Curry
Vegas baby, Vegas! Back at Insert Coin(s) LV for Game Over Fridays…
4/1 Dinner And A Mixtape's Next Stop in LA at POT
The Road Trip is half way over, and we got stops left for y'all to join us on during this cross country tour…
For this Portland edition of Dinner & A Mixtape on Tuesday night March 24th, DJ Neil Armstrong is partnering up with Saucebox 214 sw broadway near burnside : portland, oregon.
M.O.M. is your proper weekly dose of Motown, Soul, Funk, Doo-Wop, Remixes and timeless music!
Dinner and Mixtape is Coming March 23rd, in partnership with Food And Sh*t and Resident Media
Papalote & DJ Neil Armstrong Bring you for the very first time BRUNCH & A MIXTAPE – AT Papalote in the mission 3409 24th St.
DJ Neil Armstrong back in the LBC for SnapBack at Federal Bar March 20th Friday
Thursday 3/19 From 9:30 to 3 AM NuRoots @ Tokyo Beat, Downtown LA
We're going to eat our way across the United States, and here's your chance to join us.


text:
iHerb Customer Reviews
Savings of: $5.06 (84% off)
Sorry, this product is no longer in stock.
Perfect Sample Size
Posted by 4784886715748619040 on Dec 12, 2015
This krill oil is great. Doesn't taste fishy. However, it would b better if there was enough for a full week or two, to really tell the difference.
Contain higher Astaxathin
Posted by brownrice on Apr 18, 2014
I saw this product contains more natural astaxanthin, so I wanted to try it.
Posted by Reviewer1752466 on Mar 28, 2014
This product has no aftertaste, and there were no digestive problems after using it. Not exactly sure if it has done any good (I didn't feel any different), but there were no side effects.
Posted by 5748816083243916974 on Jun 20, 2016
I just wrote a review on a (Lactobif?) Pribiotic, but after submitting the review, I was given no feedback or indication that my review was accepted or even submitted. I really consider my time too valuable to be submitting reviews that are neither noticed nor recognized. When you get this little problem cleared up, please let me know. I will be happy to continue writing reviews for you.
haven't had enough to know
Posted by Reviewer2255839 on Nov 07, 2013
only 6 in the bottle ..not exactly enough to know if it does anything.
Posted by vanagelyte on Oct 31, 2013
just a trial, not gonna buy any more.
Dose too low to tell
Posted by Reviewer1108029 on Oct 23, 2013
Would need a longer trial of this product to give an honest review.
all right
Posted by 5670561747566256167 on Dec 22, 2013
Small package, easy to swallow.
Posted by Niknak on Dec 27, 2013
Only had 6 tablets but it seemed good
haven't used eyt
Posted by 5055116116083968125 on Jan 15, 2014
haven't used eyt


text:
6 of 6 people found the following review helpful
A Pleasant Read,
This review is from: Little Vampire Women (Paperback)
I suspect like many others I keep saying I will not but any more of these mash-up type novels. However, when I was in a bookshop the cover of this book caught my attention and on an impulse I decided to get it. Not really expecting much I thought this may while away some time, but I must admit that I did get caught up in the story.
Louisa May Alcott's popular classic has been added to by Lynn Messina, who has given it vampiric parts. The March's are vampires in a world that is supposedly human and vampire integrated, however there are still vampire slayers around, and so the vampires have created their own cadre, these are called defenders who are vampire slayer slayers. Jo wants to become one of these defenders.
With vampire slayers around though the family is under threat, especially from the nefarious Dr Bang, who has developed potions that can actually make vampires ill and cause them to die. With the vampiric parts added this makes the story a little bit different and should appeal to all ages, and it is quite a good read.
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Initial post: 11 Nov 2011 11:51:30 GMT
Jasmine Richards says:
I thought this was a well written, fair and open minded review. I would love to ask the reviewer M.Dowden to review a novel called Oliver Twisted by JD Sharpe. If interested please email firstname.lastname@example.com.
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As the weather warms up, children in the town of Brookfield will have a chance to dust off their fishing equipment and head to Brook Park to enjoy another edition of the Carp O'Rama Fishing Derby.
The event is open to children ages 4 to 12 and tests the young anglers' ability to catch the biggest fish. It will be held Saturday, May 31, from 8:30 to 10:30 a.m.
"We've been doing this for over 20 years," town of Brookfield Parks and Recreation Director Chad Brown said. "It's just a fun fishing event."
Carp O'Rama is open only to town of Brookfield children. Brown said the event remains relatively popular, although attendance has decreased in recent years.
"Numbers are down from the past, but we still usually get around two dozen (entrants)," he said.
Children are divided into age groups and by gender.
"We have prizes for the biggest fish, with prizes for each age group and for boys and girls," Brown said. "(Prizes) depend on the year, but usually it's fishing equipment."
Adults are not required to attend and supervise their children, although Brown recommends it, especially with younger anglers. Brown noted that the pond in Brook Park is rather shallow.
"Brook Park is surprisingly active with fishermen. People seem to be there quite a bit and, of course, with the Fox River, there seems to definitely be plenty of interest in fishing in the area," Brown said.
Carp O'Rama competitors must bring their own fishing equipment and advance registration is mandatory. The deadline to register is Thursday, May 29.
The event is in need of adult volunteers to assist throughout the morning.
If you go
WHAT: town of Brookfield Carp O'Rama Fishing Derby
WHERE: Brook Park, west of Barker Road off Brook Park Drive
WHEN: 8:30 to 10:30 a.m. May 31
REGISTER: by May 29 by calling (262) 796-3781 or sending an email to email@example.com
More from News and Features
- Mystery Photo Contest: June 30
- Residents, officials pleased with improvements at Calhoun Road railroad crossing in Brookfield
- Brookfield and Elm Grove In Brief: Elm Grove Library hosting a celebration of supper clubs
- Brookfield Ask Now: Will the pathway on Pilgrim be paved?
- Brookfield and Elm Grove Police Report: June 30
- Brookfield residents unsatisfied by reduced levels of lighting at Golf Parkway
- Brookfield and Elm Grove Meetings: June 30
- Brookfield committee to study beekeeping
- Brookfield Senior Meals: Week of July 4
- Brookfield and Elm Grove Things to Do: June 30


text:
Wiltshire: Summer Treasure Hunt
Join the Wiltshire Branch on this fun day to help improve your butterfly identification and recording skills.
Welcome to the Wiltshire Branch of Butterfly Conservation.
The future of our butterfly and moth populations in Britain is under threat with many specialist species in serious decline. Butterfly Conservation's reason for being is to save these populations by identifying the causes for the decline and carrying out corrective measures to halt and reverse the trend.
To do this successfully we need volunteer help locally in Wiltshire, particularly from those who may not yet members of BC, to record what is out there by conducting butterfly transects and moth trapping. We have to know what species we have and how they are prospering if we are to save them. Help with scrub clearance on important sites is also a vital role for volunteers.
In parallel we need to educate the community and in particular the younger generation about moths and butterflies by way of public events such as the annual Bird & Butterfly Day at Iford Manor near Bradford on Avon.
Join the Wiltshire Branch on this fun day to help improve your butterfly identification and recording skills.
All welcome at this great FREE family day out, with guided walks, moth trap displays, bat roost viewing by infra-red camera, arts and crafts, face-painting and story-telling, butterfly-friendly plants for sale and more.
Join the Wiltshire Branch on a joint trip with the Dorset Branch to explore this mixed woodland that straddles both counties.
View sightings in the Wiltshire region or submit your own records online
Transect walking is a method for assessing butterfly abundance and involves walking a fixed route, called the transect, through an area at least once a week.
Share your photographs of butterflies or moths with our Witshire Flickr group
Nature lovers are being asked to look out for a blue butterfly in Wiltshire this summer following concerns that it may be struggling, Butterfly Conservation (BC) can reveal.
More than three-quarters of the UK's butterflies have declined in the last 40 years with some common species suffering significant slumps, a major scientific study has revealed.
Could millions of Painted Ladies descend this summer?


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"Aflibercept in combination with irinotecan and fluorouracil-based therapy for treating metastatic colorectal cancer that has progressed following prior oxaliplatin-based chemotherapy." has been saved, and will be accessible from the My NGC page.
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Metastatic colorectal cancer
To evaluate the clinical effectiveness and cost-effectiveness of aflibercept in combination with irinotecan and fluorouracil-based therapy for treating metastatic colorectal cancer that has progressed following prior oxaliplatin-based chemotherapy
Patients with metastatic colorectal cancer that has progressed following prior oxaliplatin-based chemotherapy
Aflibercept in combination with irinotecan and fluorouracil-based therapy
Note from the National Guideline Clearinghouse (NGC): The National Institute for Health and Care Excellence (NICE) commissioned an independent academic centre to perform an assessment of the manufacturer's submission on the technology considered in this appraisal and prepare an Evidence Review Group (ERG) report. The ERG report for this technology appraisal was prepared by the Centre for Reviews and Dissemination/Centre for Health Economics Technology Assessment Group, University of York (see the "Availability of Companion Documents" field).
Clinical Effectiveness
Critique of the Methods of Review(s)
Search Strategy
The manufacturer's submission (MS) described the search strategies used to identify relevant clinical effectiveness studies about the use of aflibercept for the treatment of metastatic colorectal cancer (mCRC) previously treated with an oxaliplatin-containing regimen.
The electronic databases MEDLINE and MEDLINE In-Process (via PubMed), EMBASE and Cochrane Central Register of Controlled Trials (CENTRAL) were searched to identify clinical studies on the use of aflibercept in the second-line treatment of mCRC. In addition to this, abstracts of conference proceedings from the American Society of Clinical Oncology (ASCO) and the European Society of Medical Oncology (ESMO) were reviewed.
Searches were conducted on 19 December 2012. The searches covered the period 1 January 1992 to December 2012, were limited to English language publications, and excluded animal studies. In addition, the EMBASE search strategy excluded all 'conference' publication types and the 'review' publication type. The manufacturer did not explain why the search was limited by date range and to only English language publications.
Overall the searches were appropriate and well documented, and included the use of both subject indexing terms (MeSH and EMTREE) and free text searching. Field searching, Boolean operators and truncation were used where required. All the databases required by NICE were searched, though only CENTRAL was searched in the Cochrane Library when it might have been useful to have searched the Cochrane Database of Systematic Reviews (CDSR), the Database of Abstracts of Reviews of Effects (DARE) and the Health Technology Assessment (HTA) database. Information about the EMBASE service provider was not provided, but was subsequently provided via the Points of Clarification letter.
There were some issues with the use of MeSH and EMTREE terms. The PubMed search strategy included both MeSH and Major MeSH index terms; Major MeSH terms are redundant when used alongside the equivalent MeSH terms. Further, the MeSH terms used ('Colorectal Neoplasms', 'Colonic Neoplasms' and 'Rectal Neoplasms') were not exploded, and so additional MeSH terms found further down the MeSH hierarchy would not have been searched for. In the EMBASE search strategy MESH terms are used instead of EMTREE terms in search line #1.
Other issues included: a missing Boolean operator (OR) in search line #2; a redundant search line (line #11); and unnecessary repetition of search terms (lines #4 and #36). The drug name aflibercept (and related terms) was not included in the search strategies and so it is possible that potentially useful records were not retrieved. The search strategies used in the manufacturer's submission were limited to RCTs and phase II and phase III trials, however a search for other study designs such as cohort or case control studies may have provided useful supplementary information about safety. It is not clear if the methodological search filters used in PubMed, EMBASE and the Cochrane Library were derived from validated search filters. The addition of the following EMTREE terms would have improved the filter used in EMBASE: 'Randomized Controlled Trial' and 'Controlled Clinical Trial'.
Despite the issues identified above, the searches were appropriate and comprehensive, and included the use of both subject indexing terms and free text searching. Field searching, Boolean operators and truncation were used where required. It is unlikely that any relevant studies have been missed. No separate search strategy was undertaken to identify relevant studies for the meta-analysis of the adverse effects of aflibercept.
Inclusion Criteria
RCTs of all current second-line chemotherapy regimens (including, but not limited to, bevacizumab; irinotecan; folinic acid/5-fluorouracil/irinotecan [FOLFIRI]; folinic acid/5-fluorouracil/oxaliplatin 4 [FOLFOX4]; FOLFOX6; capecitabine/oxaliplatin [capeOX, XELOX]) compared with placebo, best supportive care or the same or a different second-line chemotherapy regimen, for adult patients with mCRC were eligible for inclusion in the review. Trials had to assess outcomes relating to survival, progression, response, adverse effects or quality of life to be included in the review. Only English language articles were eligible for inclusion. The inclusion criteria were appropriate for a systematic review of all second-line chemotherapy regimens for adult patients with mCRC. It appears that at the study selection stage the inclusion criteria were narrowed down so that the only intervention eligible for inclusion in the review was aflibercept.
No inclusion criteria were presented for the meta-analysis of the adverse effects of aflibercept.
ERG Comment on Manufacturer's Review of Cost-effectiveness Evidence
The manufacturer's submission described the search strategies used to identify cost-effectiveness studies relevant to this appraisal of aflibercept for the treatment of mCRC. The review was performed as part of a wider systematic review aimed to identify utility, resource use and cost estimates relevant to the appraisal. Search strategies were only briefly described in the main submission, however full details were provided in the Appendix 10 of the MS.
The electronic databases MEDLINE and MEDLINE In-Process (via PubMed), EMBASE (Dialog), EconLit (EBSCO), the Cochrane Library (Wiley) including the NHS Economic Evaluation Database (NHS EED) and the Health Technology Assessment (HTA) database were searched. In addition to this, abstracts of conference proceedings from ASCO, ESMO, World Conference on Gastrointestinal Cancer, and International Society for Pharmacoeconomics and Outcomes Research (ISPOR) were searched. Regulatory organisation websites were also searched, including NICE, the Scottish Medicines Consortium (SMC), and the All Wales Medicines Strategy Group (AWMSG).
Database searches were performed on 27 June 2012. Internet searches were performed between 27 June and 6 July 2012. The searches covered the period 2010 to 27 June 2012. Searches were not performed for publications before 2010 because the NICE multiple-technology appraisal for cetuximab, bevacizumab, and panitumumab was published that year and provided relevant economic literature to that point. Further, the manufacturer did not expect there to be any aflibercept economic analyses prior to 2010. The searches were limited to English language publications, and excluded animal studies as well as the publication types 'review' and 'case reports', and the MeSH term 'Review Literature as Topic'.
The searches were appropriate and comprehensive, and included the use of both subject indexing terms and free text searching. Field searching, Boolean operators and truncation were used where required. All NICE required databases were searched, as well as abstracts of conference proceedings and regulatory body websites. An update of the searches closer to submission might have been useful.
Methodological search filters were included to identify economic studies and utilities in MEDLINE, EMBASE and the Cochrane Library. The economic study design search filter may have excluded potentially useful records from the NHS EED database in the Cochrane Library search as this database is already limited by study design.
Inclusion/Exclusion Criteria Used for Study Selection
The manufacturer undertook a series of systematic searches to identify published economic evaluations, including cost-effectiveness, and cost-utility analyses, as well as utility, resource use and cost studies. The ERG believes that the inclusion/exclusion criteria were appropriate, and would have identified any relevant studies.
One multicentre double-blind parallel-group randomised controlled trial (RCT) of aflibercept in combination with fluorouracil/leucovorin/irinotecan (FOLFIRI) compared with placebo and FOLFIRI was included in the review, the Aflibercept Versus Placebo in Combination With Irinotecan and 5-FU in the Colorectal Cancer After Failure of an Oxaliplatin Based Regimen (VELOUR) trial.
The manufacturer's systematic review did not identify any studies that evaluated the cost-effectiveness of aflibercept for patients with metastatic colorectal cancer (mCRC).
Not applicable
Data Extraction
Two reviewers independently extracted data from the included study, reducing the potential for error or bias. The manufacturer's submission (MS) presented adequate data from the Aflibercept Versus Placebo in Combination With Irinotecan and 5-FU in the Colorectal Cancer After Failure of an Oxaliplatin Based Regimen (VELOUR) trial.
Quality Assessment
The quality of the VELOUR trial was assessed using appropriate criteria specific to randomised controlled trials (RCTs), and a table of the quality assessment results was presented. Quality assessment results were checked by the ERG.
Evidence Synthesis
No meta-analysis of efficacy outcomes was undertaken as only one study of aflibercept in the second-line treatment of metastatic colorectal cancer (mCRC) was identified in the systematic review.
A meta-analysis of aflibercept adverse events was presented, including the VELOUR trial, the VITAL trial and the VANILLA trial.
Refer to Section 4 of the ERG report for additional information on clinical effectiveness (see the "Availability of Companion Documents" field).
Conclusions of the Systematic Review
There is a paucity of evidence on the cost-effectiveness of aflibercept. The only study, identified by the ERG, was conducted in the United States (US) and established a comparison against a treatment that was not considered a relevant comparator within this appraisal, and therefore of limited relevance. Furthermore, there is a lack of detail that precludes any formal quality assessment of the study.
Summary and Critique of Manufacturer's Submitted Economic Evaluation by the ERG
Model Structure
The de novo analysis presented by the manufacturer uses a three health state Markov model (see Figure 5 in the ERG report [see the "Availability of Companion Documents" field]). The three states are: i) Stable (non-progressive) disease; ii) Progressive disease (PD); and iii) Death. The stable state is further subpartitioned into "On second-line treatment" and "Discontinued second-line treatment". Patients enter the model in the stable state and the second-line treatment substate. At each 14 days cycle, patients can either remain on second-line treatment or can discontinue second-line treatment while continuing to remain stable. Patients can also transition through the model to progressive disease (PD) or Death from either of the stable states. No reversion from the PD state to the stable state is possible.
Refer to Table 5.1 of the ERG report (see the "Availability of Companion Documents" field) for a summary of the manufacturer's economic evaluation. Refer to Section 5.2 of the ERG report (see the "Availability of Companion Documents" field) for more information on cost-effectiveness methods.
The Manufacturer's Economic Evaluation Compared to the NICE Reference Case Checklist
The manufacturer's base case economic evaluation meets the criteria of the NICE reference case checklist (see Table 5.2 of the ERG report [see the "Availability of Companion Documents" field]). No evidence synthesis was undertaken of efficacy outcomes as only one study of aflibercept in the second-line treatment of mCRC was identified in the systematic review. The ERG has been informed by their clinical advisor that other treatments (e.g., panitumumab, cetuximab and bevacizumab) are being used in clinical practice but it is not clear that this use could be considered representative of routine clinical practice, nor are any of these other treatments approved by NICE for this indication.
Refer to Section 5 of the ERG report for more information on cost-effectiveness analysis (see the "Availability of Companion Documents" field).
Technology appraisal recommendations are based on a review of clinical and economic evidence.
Technology Appraisal Process
The National Institute for Health and Care Excellence (NICE) invites 'consultee' and 'commentator' organisations to take part in the appraisal process. Consultee organisations include national groups representing patients and carers, the bodies representing health professionals, and the manufacturers of the technology under review. Consultees are invited to submit evidence during the appraisal and to comment on the appraisal documents.
Commentator organisations include manufacturers of the products with which the technology is being compared, the National Health Service (NHS) Quality Improvement Scotland and research groups working in the area. They can comment on the evidence and other documents but are not asked to submit evidence themselves.
NICE then commissions an independent academic centre to review published evidence on the technology and prepare an 'assessment report'. Consultees and commentators are invited to comment on the report. The assessment report and the comments on it are then drawn together in a document called the evaluation report.
An independent Appraisal Committee then considers the evaluation report. It holds a meeting where it hears direct, spoken evidence from nominated clinical experts, patients and carers. The Committee uses all the evidence to make its first recommendations, in a document called the 'appraisal consultation document' (ACD). NICE sends all the consultees and commentators a copy of this document and posts it on the NICE Web site. Further comments are invited from everyone taking part.
When the Committee meets again it considers any comments submitted on the ACD; then it prepares its final recommendations in a document called the 'final appraisal determination' (FAD). This is submitted to NICE for approval.
Consultees have a chance to appeal against the final recommendations in the FAD. If there are no appeals, the final recommendations become the basis of the guidance that NICE issues.
Who Is on the Appraisal Committee?
NICE technology appraisal recommendations are prepared by an independent committee. This includes health professionals working in the NHS and people who are familiar with the issues affecting patients and carers. Although the Appraisal Committee seeks the views of organisations representing health professionals, patients, carers, manufacturers and government, its advice is independent of any vested interests.
Summary of Appraisal Committee's Key Conclusions on the Evidence for Cost-effectiveness
Availability and Nature of Evidence
The Committee concluded that overall the manufacturer's model adhered to the National Institute for Health and Care Excellence (NICE) reference case for assessing cost-effectiveness.
Uncertainties Around and Plausibility of Assumptions and Inputs in the Economic Model
The Committee considered that the manufacturer's assumption that the treatment benefit continues beyond the trial period and until 15 years is highly uncertain given that most patients had died during the 3-year follow-up period of the trial. The Committee considered that the Evidence Review Group's (ERG's) analysis that allows the hazard ratio to become greater than 1.0 could be considered implausible. The Committee agreed that the ERG's scenario, which assumes equal risk of death for all patients beyond the trial period (hazard ratio equals 1.0), represents an acceptable compromise between the 2 extremes of assuming continuing treatment effect (manufacturer's base case) and allowing for a reversed treatment effect (ERG's second scenario). The Committee noted that, in response to consultation, the manufacturer implemented a new scenario in its revised base case in which the hazard ratio begins to taper to 1.0 36 months after starting treatment, over a 12-month period. The Committee agreed that as a means to extrapolate overall survival both its preferred scenario (that is, the ERG's first scenario) and the manufacturer's new scenario were associated with some degree of uncertainty. In the absence of further evidence to validate the manufacturer's new approach, the Committee maintained its preference for the ERG's first scenario.
Incorporation of Health-Related Quality-of-Life Benefits and Utility Values. Have Any Potential Significant and Substantial Health-Related Benefits Been Identified That Were Not Included in the Economic Model, and How Have They Been Considered?
The Committee was aware that the manufacturer got the utility value for the stable-disease state from the 'mCRC utilities study' and revised it after consultation to a value derived from the ASQoP (an international single-arm open-label phase III study of aflibercept). The Committee noted that the ERG preferred another value from the ASQoP study for the stable-disease state. The Committee concluded that either value could be considered appropriate.
The Committee considered that the utility value chosen by the manufacturer for the progressed-disease state did not reflect the entire duration of progressed disease but only early progressed disease, and so was likely to be an overestimate. The Committee was aware that, in its base case, the ERG used an alternative lower value of 0.60, which had been used in the NICE guideline Bevacizumab and cetuximab for the treatment of metastatic colorectal cancer (Technology appraisal guidance 118). The Committee agreed that no utility values for progressed disease were universally accepted as valid, but that it would be important that the utility value reflected the entire progressed-disease state. The Committee also agreed that adjusting the utility values for age was appropriate. The Committee concluded that the most plausible utility value for the progressed-disease health state would lie between the manufacturer's and the ERG's estimate.
The Committee concluded that all benefits of a substantial nature relating to treatment with aflibercept plus fluorouracil/leucovorin/irinotecan (FOLFIRI) had been captured in the quality-adjusted life year (QALY) calculation.
Are There Specific Groups of People for Whom the Technology Is Particularly Cost Effective?
Having considered the clinical evidence presented by the manufacturer for the 2 subgroups, the Committee concluded that it did not need to consider the cost-effectiveness of the technology for any of the subgroups.
What Are the Key Drivers of Cost-effectiveness?
The Committee considered the robustness of the mean overall survival benefit, obtained using the log-logistic function, of 3 months (5 years extrapolation time), 4.7 months (15 years extrapolation time) and 6.6 months (without truncating the survival curves).
The Committee was aware that the longer the time horizon, the greater the influence of the 'tails' of the extrapolation curves, which define the difference in mean overall survival between the treatment arms, and to which the model is highly sensitive.
The Committee noted that, because approximately three-quarters of the QALY gain in the model was accrued after disease progression, the model is highly sensitive to utility value for the progressed-disease state in the model.
Most Likely Cost-effectiveness Estimate (Given as an ICER)
The Committee noted that the manufacturer's incremental cost-effectiveness ratio (ICER) closest to its preferred assumptions was £44,000 per QALY gained (for age 60), but would increase for the higher age bracket, if the mean value was used from the manufacturer's survey of clinical oncologists after removing the outlier and if an extrapolation function with a less heavy tail had been used. Because the manufacturer's ICERs incorporated a utility value for progressed disease deemed by the Committee to be high, the Committee considered the ICER produced by the ERG using the Committee's preferred assumptions, but which used a utility value for progressed disease of 0.6. The Committee noted that this was approximately £51,000 per QALY gained and would be higher if an extrapolation function with a less heavy tail had been used. The Committee therefore concluded that the most plausible ICER was higher than the normally acceptable maximum ICER range of £20,000–30,000 per QALY gained.
Refer to Sections 3 and 4 in the original guideline document for additional information on cost-effectiveness.
Consultee organisations from the following groups were invited to comment on the draft scope, Assessment Report and the Appraisal Consultation Document (ACD) and were provided with the opportunity to appeal against the Final Appraisal Determination.
In addition, individuals selected from clinical expert and patient advocate nominations from the professional/specialist and patient/carer groups were also invited to comment on the ACD.
Aflibercept in combination with irinotecan and fluorouracil-based therapy is not recommended within its marketing authorisation for treating metastatic colorectal cancer that is resistant to or has progressed after an oxaliplatin-containing regimen.
People currently receiving aflibercept in combination with irinotecan and fluorouracil-based therapy for treating metastatic colorectal cancer that is resistant to or has progressed after an oxaliplatin-containing regimen should be able to continue treatment until they and their clinician consider it appropriate to stop.
None provided
The type of evidence supporting the recommendations is not specifically stated.
The Appraisal Committee considered clinical and cost-effectiveness evidence submitted by the manufacturer of aflibercept and a review of this submission by the Evidence Review Group. For clinical effectiveness, one randomised controlled trial (RCT) was the main source of evidence. For cost-effectiveness, the manufacturer's model was considered.
Appropriate use of aflibercept in combination with irinotecan and fluorouracil-based therapy for treating metastatic colorectal cancer that has progressed following prior oxaliplatin-based chemotherapy
The summary of product characteristics lists the following most common adverse reactions (according to the Common Terminology Criteria for Adverse Events v3.0) for aflibercept plus fluorouracil/leucovorin/irinotecan (FOLFIRI) in order of decreasing frequency: leukopenia, diarrhoea, neutropenia, proteinuria, increased plasma activity of aspartate aminotransferase, stomatitis, fatigue, thrombocytopenia, increased plasma activity of alanine aminotransferase, hypertension, weight loss, decreased appetite, epistaxis, abdominal pain, dysphonia, increased serum creatinine and headache.
For full details of adverse reactions, see the summary of product characteristics.
For full details of contraindications, see the summary of product characteristics.
The National Institute for Health and Care Excellence (NICE) has developed a costing statement explaining the resource impact of this guidance to help organisations put this guidance into practice. This tool is available from the NICE Web site (see also the "Availability of Companion Documents" field).
Not applicable: The guideline was not adapted from another source.
National Institute for Health and Care Excellence (NICE)
Appraisal Committee
Committee Members: Dr Amanda Adler (Chair), Consultant Physician, Addenbrooke's Hospital; Professor Ken Stein (Vice Chair), Professor of Public Health, University of Exeter Medical School; Dr Ray Armstrong, Consultant Rheumatologist, Southampton General Hospital; Dr Jeff Aronson, Reader in Clinical Pharmacology, University Department of Primary Health Care, University of Oxford; Professor John Cairns, Professor of Health Economics Public Health and Policy, London School of Hygiene and Tropical Medicine; Mark Chapman, Health Economics and Market Access Manager, Medtronic UK; Professor Fergus Gleeson, Consultant Radiologist, Churchill Hospital, Oxford; Robert Hinchliffe, HEFCE Clinical Senior Lecturer in Vascular Surgery and Honorary Consultant Vascular Surgeon, St George's Vascular Institute; Professor Daniel Hochhauser, Consultant in Medical Oncology, UCL Cancer Institute; Dr Neil Iosson, General Practitioner; Anne Joshua, Associate Director of Pharmacy, NHS Direct; Dr Rebecca Kearney, Clinical Lecturer, University of Warwick; Professor Ruairidh Milne, Director of Strategy and Development and Director for Public Health Research at the National Institute for Health Research (NIHR) Evaluation, Trials and Studies Coordinating Centre at the University of Southampton; Dr Elizabeth Murray, Reader in Primary Care, University College London; Dr Peter Norrie, Principal Lecturer in Nursing, DeMontfort University; Dr Sanjeev Patel, Consultant Physician & Senior Lecturer in Rheumatology, St Helier University Hospital; Dr John Pounsford, Consultant Physician, Frenchay Hospital, Bristol; Alun Roebuck, Consultant Nurse in Critical and Acute Care, United Lincolnshire NHS Trust; Roderick Smith, Chief Finance Officer, Coastal West Sussex Clinical Commissioning Group; Cliff Snelling, Lay Member; Professor Andrew Stevens, Professor of Public Health, Department of Public Health and Epidemiology, University of Birmingham; Dr Nicky Welton, Senior Lecturer in Biostatistics/Health Technology Assessment, University of Bristol
Committee members are asked to declare any interests in the technology to be appraised. If it is considered there is a conflict of interest, the member is excluded from participating further in that appraisal.
Electronic copies: Available from the National Institute for Health and Care Excellence (NICE) Web site .
The following are available:
The following is available:
Please note: This patient information is intended to provide health professionals with information to share with their patients to help them better understand their health and their diagnosed disorders. By providing access to this patient information, it is not the intention of NGC to provide specific medical advice for particular patients. Rather we urge patients and their representatives to review this material and then to consult with a licensed health professional for evaluation of treatment options suitable for them as well as for diagnosis and answers to their personal medical questions. This patient information has been derived and prepared from a guideline for health care professionals included on NGC by the authors or publishers of that original guideline. The patient information is not reviewed by NGC to establish whether or not it accurately reflects the original guideline's content.
This NGC summary was completed by ECRI Institute on June 5, 2014.
The National Institute for Health and Care Excellence (NICE) has granted the National Guideline Clearinghouse (NGC) permission to include summaries of their Technology Appraisal guidance with the intention of disseminating and facilitating the implementation of that guidance. NICE has not verified this content to confirm that it accurately reflects the original NICE guidance and therefore no guarantees are given by NICE in this regard. All NICE technology appraisal guidance is prepared in relation to the National Health Service in England and Wales. NICE has not been involved in the development or adaptation of NICE guidance for use in any other country. The full versions of all NICE guidance can be found at www.nice.org.uk .
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|By Marketwired .
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|March 3, 2013 08:00 AM EST
SAN FRANCISCO, CA -- (Marketwire) -- 03/03/13 -- Recommind, the leader in unstructured data management, analysis and governance technology, will join 37,000 healthcare industry professionals next week, March 3 to March 7, at the 2013 Annual HIMSS Conference and Exhibition in New Orleans.
Recommind is a first-time sponsor and exhibitor at this annual event, where healthcare industry professionals discuss health information technology issues and review innovative solutions designed to transform healthcare.
Visit booth #4079 to learn how Recommind's customers are benefiting from its end-to-end eDiscovery, enterprise search, email management and automatic categorization software, which helps improve access to information and unlock the insights required to transform healthcare outcomes. Learn how your company can benefit from Recommind's healthcare solutions, which include the following:
- Information governance: Caring for your data
- Search: Identifying connections across the enterprise
- SharePoint optimization: Accessing clinical and operational policies
- Projects and expertise: Enhancing referral networks
- Contract analysis: Surfacing key information
- eDiscovery: Uncovering key data for litigation
About Recommind
Recommind is a leader in unstructured data management, analysis and governance technology, delivering search-powered business applications that transform the way organizations find, manage, analyze and act upon data inside and outside the corporate network. Recommind's solutions are all built on the CORE platform, which automatically accesses, organizes and analyzes large volumes of information in context from myriad sources. Recommind customers include AstraZeneca, BMW, Cisco, Clifford Chance, Marathon Oil, Morgan Lewis, US Department of Energy (DOE), White & Case and WilmerHale. Recommind is headquartered in San Francisco and has offices in New York, Boston, London, Sydney and Bonn, Germany. For more information go to www.recommind.com
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Email: [email protected]
Call: +1 415 394 7899
IoT is rapidly changing the way enterprises are using data to improve business decision-making. In order to derive business value, organizations must unlock insights from the data gathered and then act on these. In their session at @ThingsExpo, Eric Hoffman, Vice President at EastBanc Technologies, and Peter Shashkin, Head of Development Department at EastBanc Technologies, discussed how one organization leveraged IoT, cloud technology and data analysis to improve customer experiences and effi...
Jun. 28, 2016 07:15 PM EDT Reads: 317
The IoT is changing the way enterprises conduct business. In his session at @ThingsExpo, Eric Hoffman, Vice President at EastBanc Technologies, discussed how businesses can gain an edge over competitors by empowering consumers to take control through IoT. He cited examples such as a Washington, D.C.-based sports club that leveraged IoT and the cloud to develop a comprehensive booking system. He also highlighted how IoT can revitalize and restore outdated business models, making them profitable ...
Jun. 28, 2016 06:30 PM EDT Reads: 324
Predictive analytics tools monitor, report, and troubleshoot in order to make proactive decisions about the health, performance, and utilization of storage. Most enterprises combine cloud and on-premise storage, resulting in blended environments of physical, virtual, cloud, and other platforms, which justifies more sophisticated storage analytics. In his session at 18th Cloud Expo, Peter McCallum, Vice President of Datacenter Solutions at FalconStor, discussed using predictive analytics to mon...
Jun. 28, 2016 04:30 PM EDT Reads: 447
There are several IoTs: the Industrial Internet, Consumer Wearables, Wearables and Healthcare, Supply Chains, and the movement toward Smart Grids, Cities, Regions, and Nations. There are competing communications standards every step of the way, a bewildering array of sensors and devices, and an entire world of competing data analytics platforms. To some this appears to be chaos. In this power panel at @ThingsExpo, moderated by Conference Chair Roger Strukhoff, Bradley Holt, Developer Advocate a...
Jun. 28, 2016 04:30 PM EDT Reads: 900
"SpeedyCloud's specialty lies in providing cloud services - we provide IaaS for Internet and enterprises companies," explained Hao Yu, CEO and co-founder of SpeedyCloud, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Jun. 28, 2016 02:45 PM EDT Reads: 924
A strange thing is happening along the way to the Internet of Things, namely far too many devices to work with and manage. It has become clear that we'll need much higher efficiency user experiences that can allow us to more easily and scalably work with the thousands of devices that will soon be in each of our lives. Enter the conversational interface revolution, combining bots we can literally talk with, gesture to, and even direct with our thoughts, with embedded artificial intelligence, wh...
Jun. 28, 2016 02:00 PM EDT Reads: 1,140
"Avere Systems is a hybrid cloud solution provider. We have customers that want to use cloud storage and we have customers that want to take advantage of cloud compute," explained Rebecca Thompson, VP of Marketing at Avere Systems, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Jun. 28, 2016 02:00 PM EDT Reads: 473
Machine Learning helps make complex systems more efficient. By applying advanced Machine Learning techniques such as Cognitive Fingerprinting, wind project operators can utilize these tools to learn from collected data, detect regular patterns, and optimize their own operations. In his session at 18th Cloud Expo, Stuart Gillen, Director of Business Development at SparkCognition, discussed how research has demonstrated the value of Machine Learning in delivering next generation analytics to imp...
Jun. 28, 2016 01:00 PM EDT Reads: 826
The cloud market growth today is largely in public clouds. While there is a lot of spend in IT departments in virtualization, these aren't yet translating into a true "cloud" experience within the enterprise. What is stopping the growth of the "private cloud" market? In his general session at 18th Cloud Expo, Nara Rajagopalan, CEO of Accelerite, explored the challenges in deploying, managing, and getting adoption for a private cloud within an enterprise. What are the key differences between wh...
Jun. 28, 2016 12:45 PM EDT Reads: 961
Creating replica copies to tolerate a certain number of failures is easy, but very expensive at cloud-scale. Conventional RAID has lower overhead, but it is limited in the number of failures it can tolerate. And the management is like herding cats (overseeing capacity, rebuilds, migrations, and degraded performance). Download Slide Deck: ▸ Here In his general session at 18th Cloud Expo, Scott Cleland, Senior Director of Product Marketing for the HGST Cloud Infrastructure Business Unit, discusse...
Jun. 28, 2016 12:15 PM EDT Reads: 1,034
The pace of innovation, vendor lock-in, production sustainability, cost-effectiveness, and managing risk… In his session at 18th Cloud Expo, Dan Choquette, Founder of RackN, discussed how CIOs are challenged finding the balance of finding the right tools, technology and operational model that serves the business the best. He also discussed how clouds, open source software and infrastructure solutions have benefits but also drawbacks and how workload and operational portability between vendors ...
Jun. 28, 2016 12:00 PM EDT Reads: 1,039
University of Colorado Athletics has selected FORTRUST, Colorado's only Tier III Gold certified data center, as their official data center and colocation services provider, FORTRUST announced today. A nationally recognized and prominent collegiate athletics program, CU provides a high quality and comprehensive student-athlete experience. The program sponsors 17 varsity teams and in their history, the Colorado Buffaloes have collected an impressive 28 national championships. Maintaining uptime...
Jun. 28, 2016 12:00 PM EDT Reads: 606
It's easy to assume that your app will run on a fast and reliable network. The reality for your app's users, though, is often a slow, unreliable network with spotty coverage. What happens when the network doesn't work, or when the device is in airplane mode? You get unhappy, frustrated users. An offline-first app is an app that works, without error, when there is no network connection. In his session at 18th Cloud Expo, Bradley Holt, a Developer Advocate with IBM Cloud Data Services, discussed...
Jun. 28, 2016 12:00 PM EDT Reads: 929
The initial debate is over: Any enterprise with a serious commitment to IT is migrating to the cloud. But things are not so simple. There is a complex mix of on-premises, colocated, and public-cloud deployments. In this power panel at 18th Cloud Expo, moderated by Conference Chair Roger Strukhoff, Randy De Meno, Chief Technologist - Windows Products and Microsoft Partnerships at Commvault; Dave Landa, Chief Operating Officer at kintone; William Morrish, General Manager Product Sales at Interou...
Jun. 28, 2016 11:30 AM EDT Reads: 978
What does it look like when you have access to cloud infrastructure and platform under the same roof? Let's talk about the different layers of Technology as a Service: who cares, what runs where, and how does it all fit together. In his session at 18th Cloud Expo, Phil Jackson, Lead Technology Evangelist at SoftLayer, an IBM company, spoke about the picture being painted by IBM Cloud and how the tools being crafted can help fill the gaps in your IT infrastructure.
Jun. 28, 2016 10:00 AM EDT Reads: 886
Apixio Inc. has raised $19.3 million in Series D venture capital funding led by SSM Partners with participation from First Analysis, Bain Capital Ventures and Apixio's largest angel investor. Apixio will dedicate the proceeds toward advancing and scaling products powered by its cognitive computing platform, further enabling insights for optimal patient care. The Series D funding comes as Apixio experiences strong momentum and increasing demand for its HCC Profiler solution, which mines unstruc...
Jun. 28, 2016 10:00 AM EDT Reads: 415
Digital Initiatives create new ways of conducting business, which drive the need for increasingly advanced security and regulatory compliance challenges with exponentially more damaging consequences. In the BMC and Forbes Insights Survey in 2016, 97% of executives said they expect a rise in data breach attempts in the next 12 months. Sixty percent said operations and security teams have only a general understanding of each other's requirements, resulting in a "SecOps gap" leaving organizations u...
Jun. 28, 2016 09:45 AM EDT Reads: 1,155
[session] The Factory of the Future, Today By @Cisco | @ThingsExpo #IoT #BigData #DigitalTransformation
IoT offers a value of almost $4 trillion to the manufacturing industry through platforms that can improve margins, optimize operations & drive high performance work teams. By using IoT technologies as a foundation, manufacturing customers are integrating worker safety with manufacturing systems, driving deep collaboration and utilizing analytics to exponentially increased per-unit margins. However, as Benoit Lheureux, the VP for Research at Gartner points out, "IoT project implementers often ...
Jun. 28, 2016 09:45 AM EDT Reads: 451
It is one thing to build single industrial IoT applications, but what will it take to build the Smart Cities and truly society changing applications of the future? The technology won't be the problem, it will be the number of parties that need to work together and be aligned in their motivation to succeed. In his Day 2 Keynote at @ThingsExpo, Henrik Kenani Dahlgren, Portfolio Marketing Manager at Ericsson, discussed how to plan to cooperate, partner, and form lasting all-star teams to change t...
Jun. 28, 2016 09:30 AM EDT Reads: 1,302
"A lot of times people will come to us and have a very diverse set of requirements or very customized need and we'll help them to implement it in a fashion that you can't just buy off of the shelf," explained Nick Rose, CTO of Enzu, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Jun. 28, 2016 09:00 AM EDT Reads: 1,162


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The 2013-14 Covenant men's basketball team, under head coach Kyle Taylor, recently unveiled this season's schedule. The Scots will play 25 contests with 14 of those coming inside the USA South Athletic Conference.
The scheduled is highlighted with a trip to Minnesota in December and an exhibition against NCAA Division I member Chattanooga on November 8 along with the first year of play in the USA South.
"After five years of futile attempts I am really excited to have UTC on our schedule," said Taylor who will enter his fifth year as the head of the program. "This will be UTC's home opener in their newly refurbished arena, with a great new coach in Will Wade. The atmosphere will be incredible for our guys and hopefully a lot of Covenant students, faculty and staff, and alumni will come to the game."
The Scots then open the season at Berry on November 15 followed by a tilt with Emory & Henry, in Rome, Ga., the next day. The 2013-14 home opener is scheduled for November 20 against Sewanee.
Covenant will travel to Minnesota on December 6-7 to take on Crown and Bethany Lutheran before coming home to play Berry and Birmingham Southern to finish the semester.
USA South play opens up on January 3 against Ferrum on Lookout Mountain. Covenant will play its first four conference games at home. The final regular season contest is set for February 22 at home against LaGrange.
"Having a conference is so huge for our guys, and we are especially excited about being a full active member of the USA South Athletic Conference and NCAA Division III," added Taylor. "Getting to play for a conference championship and a spot in the postseason will be a great experience for our student athletes."
The top eight teams in the final USA South regular season standings will qualify for the conference tournament held at the end of February. The top seeded team will be the host for the three-day event.
Covenant finished 13-11 last season marking the first winning season since 1998-99.
June 26, 2016
The Minnesota Twins turned Yankee Stadium into a launchpad in the sixth inning of a 7-1 victory Sunday over the Yankees. Three homers were hit back-to-back-to back, including one ... (click for more)
Jack Smith and Ryan Greer won the 49th Tennessee Four-Ball Championship on Saturday at the Black Creek Club. Smith and Greer defeated Lake Johnson and Scott Stevens, 4 and 3, in the final. ... (click for more)
Jay Potter and Sport Allmond shot 61 on Saturday and took the lead in the Moccasin Bend Four-Ball at the Moccasin Bend Golf Club. David Watts and Matt Crowder finished second after the first ... (click for more)
The Minnesota Twins turned Yankee Stadium into a launchpad in the sixth inning of a 7-1 victory Sunday over the Yankees. Three homers were hit back-to-back-to back, including one by former Lookouts' outfielder Max Kepler. Ironically the home runs were hit off another ex-Lookout, RHP Nathan Eovaldi. On the mound for Minnesota was Tyler Duffey, ... (click for more)
Jack Smith and Ryan Greer won the 49th Tennessee Four-Ball Championship on Saturday at the Black Creek Club. Smith and Greer defeated Lake Johnson and Scott Stevens, 4 and 3, in the final. ... (click for more)
A home in Ooltewah was damaged by fire early Sunday afternoon. At 4:33 p.m. , the homeowner called 911 reporting a fire at the residence at 711 Rocky Shadows Drive (Mountain Shadows subdivision in the Ooltewah area). The Tri-Community Volunteer Fire Department responded and arrived on the scene reporting light smoke showing from the roofline. Firefighters entered ... (click for more)
The grand opening of the Bass Pro Shops East Ridge Outpost kicks off Wednesday, July 13, at 6 p.m . The event features an all-star cast of celebrities from the world of sports, entertainment and the great outdoors who will join together to help Bass Pro Shops celebrate an Evening for Conservation. The grand opening event will continue through Sunday, July 17, ... (click for more)
I'm pleased and indeed compelled to let you know a bit more about the exciting and most honorable "Charles H. Coolidge Medal of Honor Heritage Center" planned for Coolidge Park. Here's what the Heritage Center will be: It will be a fitting capstone for Chattanooga's Coolidge Park on Northshore in downtown Chattanooga. While this exceptional Chattanooga ... (click for more)
George Will, easily one of the most respected conservative columnists in America and a Republican commentator, was a guest on Fox News Sunday yesterday when he made a very revealing statement. He announced he has left the Republican Party "for the same reason I joined it" and that he is not only disappointed by the party's actions but its increasingly-inept leadership as well. ... (click for more)


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Mumbai United States Department of Agriculture (USDA) Foreign Agricultural Service, Mumbai recently organised an interaction between celebrity... ...http://www.financialexpress.com/article/fhw/market-fhw/united-states-department-of-agriculture-promotes-indo-us-fandb-exchange/286121/
It's vacation time. And in today's age of exactness, distinctiveness and the need for specificity of experiences, a vacation is no longer just a... ...http://m.hindustantimes.com/health-and-fitness/kunal-vijayakar-on-finding-good-indian-food-while-travelling-abroad/story-LpBjBa4arEMSxikIhbXi5H.html
Vir Sanghvi These are good times for Indian food abroad. A few weeks ago, I wrote about Gaggan Anand, whose eponymous Bangkok restaurant has been... ...http://www.navhindtimes.in/why-does-indian-food-not-get-the-respect-it-deserves/
Indian curry has tickled the taste buds of millions of Brits, who have discarded their traditional dinner staple of Fish and Chips to enjoy... ...http://www.news18.com/news/lifestyle/why-is-the-west-fancying-turmeric-latte-1251703.html
Mumbai's (relatively) new hotspot, The Bombay Canteen, is dishing out all things cold this summer. Their new Thanda Thanda Cocktails come in three... ...http://elle.in/blog/we-sampled-the-bombay-canteens-thanda-menu/


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New Orleans Handicap Equipment
1. Mr Wheelchair
Very helpful when I called. Checked to make sure they had the item I was looking for and let me know the price. Friendly sounding over the phone.
2. Apria Healthcare
I wish I had never ever called them. Absolutely shocking and ignorant company. You can't leave the rating without a star, otherwise I would have…
3. Louisiana Elevator Corporation
1525 River Oaks Rd ENew Orleans, LA 70123
4. ThyssenKrupp Elevator
1525 River Oaks Rd ENew Orleans, LA 70123
5. Total Access Mobility Services
500 Port Of New Orleans PlNew Orleans, LA 70130
From Business: Total access is a short term mobility rental Company. We rent OUT electrical scooters. Wheelchairs. And strollers.
6. Thyssen Krupp Elevator
1533 Sams Ave # ANew Orleans, LA 70123
7. Southern Rehab & Home Medical Equipment Center
3511 River RdNew Orleans, LA 70121
8. First Century Medical Supply Inc
637 S. Pierce StNew Orleans, LA 70119
9. DAS Construction
4711 Saint Bernard AveNew Orleans, LA 70119
10. Omni Mobility Services
101 Brookhollow EsplanadeNew Orleans, LA 70123
11. Easy Climber Stairlift
Serving the New Orleans Area.
From Business: You have many reasons to choose an Easy Climber stair lift, but the best one is to protect your loved one's safety. No other reason compares to the relief you'll fe…
12. Superior Van & Mobility
1901 Westbank Expy Suite 500Harvey, LA 70058
From Business: Superior Van & Mobility is an industry leader providing mobility solutions for the consumer and commercial transportation industry. Superior is a proud member of th…
13. U.S. Medical Supplies
Have a hospital bed never been plugged up and electric wheelchairs was trying to sale them if anyone is in need of one the chair lays back and just…
14. Step-N-Shower
3116 Saint Rene StMetairie, LA 70001
15. Ab Oxygen Inc
749 Aurora #3Metairie, LA 70005
16. College Mobility
1415 Whitney AveGretna, LA 70053
17. A & E Medical Repair
Metairie, LA 70001
From Business: Medical Repair Service Inc. Here at Medical Repair Service Inc., we are dedicated to you and all your different medical repair needs. We've been around for over 20 …
18. Crescent Vans
From Business: Our staff has over 100 years combined experience in the adaptive equipment industry. Our showroom is conveniently located in Metairie off David Drive & Airline Hwy.…
19. Access Respiratory Homecare
Nice selection of products. The man who heled me was friendly and took his time explaining my equipment and insurance coverage. I even got follow up…
20. Drugs Patio
We were some of their first customers and many staff still there 50yrs later. That says quality. Honest. Impressive inventory of pharmacy items not …
21. Egan Healthcare Services
Egan Healthcare did a wonderful job with my great aunt. I have nothing but good things to say about the company and service.
22. Total Health Solutions
Like your opening telephone message the requirement of writing a review is confusing.What if I have no pros? What if I have no cons? A remark can be…
23. Champagne Elevators A Division Of Winter Elevator Services
3715 Division StMetairie, LA 70002
24. Casey Supply
826 24th StKenner, LA 70062
25. Scooter World LLC
2248 Front StSlidell, LA 70458
From Business: Slidell's largest inventory of new & used mobility scooters & the lowest prices around!
26. Grace Healthcare Medical Equipment
1071 Ste 10 Roberts BlvdSlidell, LA 70458
27. All American Cargo Elevators
59390 Transmitter RdLacombe, LA 70445
28. All American Cargo Elevators
2707 Gause Blvd WSlidell, LA 70460
29. Advanced Rehab Technologies
500 Mariners Plaza DrMandeville, LA 70448
30. 101 Mobility
434 Red Maple DrMandeville, LA 70448


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Using state-of-the-art projection technology, Jaguar Land Rover attempted to transform a cold autumn night in London into a golden summer day for the launch of its new Range Rover Evoque Convertible. The four-seat, luxury crossover's lightweight fabric hood gives it the honor of being the world's first luxury compact SUV convertible.Read More
The British are a singularly odd bunch when it comes to things automotive. When they fail to amaze, they do an epic job of it, but when they do hit the mark, they do so with such perfection that it's awe inspiring. The 2016 Jaguar F-Type R Convertible falls squarely into the latter camp and for us, this particular car is so utterly perfect that all other vehicles are henceforth relegated to the sad "not an F-Type" bin.Read More
Since the launch of the new Mini, we've seen a greater focus on usability and space. Unfortunately, none of this newfound practicality has addressed the biggest problem with Mini, a problem that has existed since the death of the R56 Cooper in 2013: the need to improve your tan. Thankfully, stylish socialites can rest easy, because Mini has answered your prayers with its new Convertible.Read More
HP's new Windows 10 hybrid has a premium build, good specs and puts the keyboard in the box as standard. It's positioned to compete directly with Microsoft's Surface line, and offers some high-end extras, like quad Bang & Olufsen speakers.Read More
The last time we looked in on the Range Rover Evoque Convertible, it was burrowing through the earth below London. The still-camouflaged crossover has been out having fun once again. Land Rover has put the car through its off-road paces in preparation of next month's launch.
Read More
Google introduced the Pixel C tablet, its apparent answer to the Microsoft Surface Pro 3 and Apple's iPad Pro, at an event in San Francisco Tuesday morning. The slate will run Android Marshmallow rather than Chrome OS, works with an optional magnetic Bluetooth keyboard and is cheaper than its leading competitors.Read More
Lamborghini has ripped the top off its Huracán, turning it into a rival for the McLaren 650S Spyder and the recently-turbocharged Ferrari 488 GTB Spyder. It might not pack turbocharged power like its closest rivals, but the Huracán Spyder LP 610-4 still has a few tricks up its sleeve to help it stand out. Read More
Having targeted younger buyers with the Wraith last year, Rolls-Royce has decided to turn its hand to the four-seat cabriolet. The new Rolls-Royce Dawn is aimed at delivering the same whisper quiet, ultra luxurious experience to those who want to enjoy top-down motoring without all the windy, noisy hassle.Read More
Mercedes has added yet another string to its top-end luxury bow with a new variant of the S-Class. The S-Class Cabriolet joins long wheelbase, short wheelbase, coupe and super luxurious Maybach versions of Mercedes' flagship, backed by the bold claim that it is the world's most luxurious convertible.Read More
Acer's latest Chromebook R11 offers something a little different for a machine running Google's cloud-centric OS. With a 360-degree hinge, you can flip the device's display all the way around to the back of the keyboard, just like numerous Windows convertibles, including the Lenovo Yoga range.Read More
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Other features include: -- Low-offset voltage to frequency converter (VFC) for accurate charge and discharge counting -- Internal time-base for reduced component count -- On-chip configuration EEPROM for application specific parameters -- Programmable input/output port The bqJunior takes advantage of TI's new LBC4 copper CMOS process node, which helps to achieve new levels of integration, low power and performance.
What does VFC stand for?
VFC stands for Voltage to Frequency Converter
This definition appears frequently and is found in the following Acronym Finder categories:
- Information technology (IT) and computers
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We have 92 other meanings of VFC in our Acronym Attic
- Abbreviation Database Surfer
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|SUMMARY: Just in time for summer, here's an all-new Case Study about the beach site that went on a diet. Virginia Beach official Web site slimmed down navigation and home page clutter to be more appealing to tourists. Plus, they added more content for French and Spanish-speaking travel planners. How do you simplify while adding content? Plus, how do you make your site appealing for visitors from other cultures? Practical tips plus results data at:
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