text:
Submitting personal info is optional, just save a profile and play for Free!
What's New
Animal Jigsaw Puzzles
How to play:
Drag the puzzle pieces to the right place in order to recreate the image.
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Animal Puzzle
We have only one earth. It gives birth to all things. Many animals live on earth with us. They live in ocean, fly in sky or inhabit barren desert or grasslands. Please open your mind to know and appreciate them. Furthermore, encourage our kids to know them more. These beautiful animals are our priceless treasures.
As long as we are willing to pay more love to the world, we will have more. Come on! Let's know and protect the animals. Start it from heart.
Introduction of the game:
The photo will be cut into 3x3 or 4x4 disarranged pieces. You must put all puzzle pieces at the correct position. You can press "Hint" to check the whole photo or press "introduction" to see the information of the animal. When you complete it, you can set the photo as your wallpaper and go to next game.
We always do our best to test the program while we release it. However, there are various models of mobile phone for Android system. Please kindly Email to us , tell us what step cause bug. We very appreciate your understanding and support.
Animals Puzzle For Kids
Watch them learn all the names of numerous pet, farm, jungle, zoo and water animals through fun and play. A pleasant voice will always encourage and praise your kids and motivate them to continue to build their vocabulary, memory, and cognitive skills while playing. The game is enriched with animations, pronunciations, sounds and interactivity for repeat playing & learning. It will keep your kids busy and yet you will never be worried about them losing any piece of the puzzles!
Simple & intuitive child-friendly interface
Universal app for all phones and tablets
15 different languages and pronunciations (English, Arabic, Chinese, French, German, Italian, Korean, Portuguese, Russian, Spanish, Turkish, Ukrainian, Polish, Dutch & Japanese)
Hundreds of puzzle pieces in 84 different puzzles
Easy navigation between puzzles
Easy movement of puzzle pieces across screen
High-quality graphics
Sweet background music
Drag & drop animations
Balloon animation & happy cheering after each correctly solved puzzle
The theme of this Puzzle is 'Animals', check our other apps for more themes like 'Food', 'Kitchen', 'Furniture', 'Bathroom', 'Cars' and 'Tools'
And last but not least ***All puzzles are available for FREE***
Privacy Disclosure:
As parents ourselves, iAbuzz takes children's wellness and privacy very seriously. Our app:
• Does not contain links to social networks
• Does not contain any in-app purchases
• Does not collect personal data
But yes, it does contain advertising as that's our means of providing the app free of cost to you – the ads are carefully placed such that the kid is least likely to click on it while playing.
Feedback Please:
If you have any feedback and suggestions on how we could further improve the design and interaction of our apps and games, please visit our website http://iabuzz.com/ or leave us a message at email@example.com. We would be glad to hear from you as we are committed to update all of our apps and games on a regular basis with new features and also want to get some ideas for future app development.
Onet Funny Animal
You have to remove all cards by connecting two matching cards with no more than 3 straight lines.
If you like connecting or matching game, you will love to play Funny Animal.
This game free for everyone.
Animals Games for kids
This entertaining and educational game for preschool kids helps develop motor skills, hand-eye coordination, imagination, and creativity. It aims to teach children shapes, image recognition, and number pronunciation.
Memory: This is the classic game of cards where you have to find pairs of animal-related images. It has over 40 stages, each of them harder than the last and will challenge even the adults ability to memorize positions at the later levels. Matching games are a great way to improve your kids' short-term memory skills, develop their concentration, and cognitive skills!
Advanced Memory Game: The idea as in the previous game, just need to find 3 identical cards.
Jigsaw Puzzle: One of the many animals images gets cut up into small pieces and it's up to you to put it back in the right order to complete the image. It has over 60 stages, each of them harder than the previous. You can see a preview of the image if you don't know what it is you're trying to put together.
Shape Puzzle: The goal is to move shapes into the outline of an object. Once all of the puzzle pieces are in place, the object fills in with a compete image, and a voice gives some sort of encouragement, such as, "Good job!", etc.
When you place the piece inside the puzzle's outline, it snaps into place.
Comes with 100 levels, which should keep you kids busy for a long time.
Connect The Dots: This game allows your preschool-age child to practice numbers and image recognition.
The child must simply touch the numbers in sequence, and the app will draws the line for them.
Each number is announced after pressing. The program is able to announce the numbers in 17 different languages: English, Spanish, German, French, Japanese, Korean, Russian, Italian, Dutch, Finnish, Norwegian, Swedish, Danish, Portuguese, Hindi, Chinese(Traditional), and Chinese(Simplified).
When a child reaches the last number, the object fills in with a detailed cartoon image of the thing that you just traced.
Scratch: Draw your finger over the screen to clear out a piece of the image. This is the least game-like of the 5, but it is also the one with the most creative freedom. With three thicknesses of the pen and three modes, you or your child can create nice effects or frames on the pictures. There's Block Mode, that blocks out the image with a blue screen. As you draw over the screen, you see more of the image underneath. A creative person might make a nice frame or draw figures on the blue surface. The Black And White mode has a B/W image and as you draw over it, you get colors. The Frost Mode makes the image look like you're seeing it through a window with frost all over it. As you draw, you clear some of the frost, making it look like you're scratching away the frost on the window to peek inside.
The game is optimized for Android phones and tablets.
With this learning exercise children will have hours of fun.
Hidden Objects: Animal Kingdom
Get "INTO THE ANIMAL KINGDOM" NOW.
16 levels FULL of animals and other hidden objects!
Test your knowledge of animals and FIND THEM ALL!
Casual! Take your time and enjoy the pure fun of hidden objects!
Challenge! Take it to the next level! Challenge your reflexes in this speed mode!
Blitz!!! PROVE yourself to be the ultimate hidden object lover!!!!!
Find by Picture! The easy yet fun way to kill your time!
Find by Silhouette! Challenge yourself! Guess and find out what they are exactly!
Find by Word! Forget the gimmick! You find what you read!!!
DOWNLOAD Hidden Objects: Into the Animal Kingdom TODAY!!!!!
Coloring Game Animals
Tags: Coloring, coloring, Colory, colory, Game, game, Kid, kid, Kids, kids, child, children, preschool-age, kindergarten, animal, animals
Puzzle - Wild animals
- This game contain Multi levels :
- 4 * 4
- 5 * 5
- 6 * 6
- 7 * 7
- 8 * 8
- You can move any Slice To make the whole picture.
- Simple and intuitive
- Improve thinking abilities
- You can save the images after assembling the puzzle in your device.
- We all can enjoy it.
just assemble the photo and have fun.
Wild animals puzzle: Jigsaw
Drag the puzzle pieces to the right place in order to recreate the image. The more you advance, the harder the puzzle gets!
Wild animals puzzle features:
★ Lots of Photos / levels
★ Multiple skill levels
★ Hint system
★ Level selector
★ Save images to SD
★ Set images as wallpaper
★ Save game to SD
★ Free game
This game has pictures of lots of different animals. These are wild animals like tigers, lions, elephants, pandas and bears.
Also check out our other fun jigsaw puzzle games!
Follow us on Facebook, Twitter or Google+ and please keep emailing us with any questions or feedback!
Copyright © MadRabbit Studio 2013
Fun With Animals Matching Game
It is not only capable of being challenging enough for adults but also as easy as for kids and toddlers to play. This game adds a level of cute to everyday matching games, by using colorful and vivid graphics for each card.
After all cards are laid face down, they are flipped over by the player over each turn.
Player must then recall where they and touch them to create a match.
Exercise your retention, mnemonic skills trying to find two same cards. Matching pairs is not only fun but also educational.
The game has three categories:
Easy, hard and time based.
Easy part consists 4x4 matrix, Hard part consist of 6x6 and lastly time based part consists of 6x6 matrix and you will have 90 sec. If you have time after finishing the game, it will be points of your score. You will see your score after competition.
Download Fun With Animals matching game and enjoy, in one of the best apps for preschool students!
-Cute farm animals
-Colourful images
-Flip the cards
-Match the pairs
-Different difficulty levels easy, hard and time
-Easy and simple to play
-Have fun playing
Play fun with animals matching game regularly and you will see your retention, memory skills improve, concentration levels rise and will have a better ability to focus easily. This excellent mind trainer will give you and your kid an excellent "brain training" activity. It is completely free of charge and you'll get the best brain gym.
If you like our app please rate it, comment and give us feedback for further update, for better application.
Thank you!
Toddler Animal Numbers Ad Free
Learning to count is one of the most fundamental skills that pre-school children aim to master. It is a universal development milestone and their first introduction to the world of mathematics. Children have a concept of numbers even before their 1st birthday and many can recite a few numbers in sequence by their 2nd birthday. By the time they enter school, children can use counting to determine the size of a set.
This application demonstrates the basic concept of counting to pre-school children, the names of the numbers from 1 to 10 and their order, the fact that each item can only be
used once in counting and that the order they choose to count does not alter the result. The application uses beautifully drawn images of diverse animals and an artists voice
that recites the number while they are being counted. By simply touching them with their finger, children can start counting the animals as they appear on the screen. The order
they touch the animals does not make a difference in the final result.
We hope you and your young children enjoy the experience!
Onet Connect Animal
How to play Onet Connect Animal ?
- Remove 2 animal with the same kind which can be connected within 3 lines.
- Classic game play
- nice graphic.
have fun of playing Onet Connect Animal!
Animal Jigsaw Tile Puzzle
introduction of the game:
animals cartoon jigsaw puzzle is a kind of entertainment puzzle games.
how to play?
* choose animal cartoon image.
* drag and drop the tile of the image to the correct place.
* do that until you build the original image.
* there are three levels of difficalty.
* designed for all android devices.
* amazing user interfaces.
* update the images weekly.
this application does not violate the copyright and does not claim to it.
most of the images are collected under license of shutterstock.com.
if you feel that we violate your copyright please contact us directly.
try the game for free.
Animals Memo
Animal Puzzle For Toddlers LT
You can now select the difficulty of the puzzles from the options menu.
- Puzzles for all ages
- Level of difficulty increases with each puzzle
- Easy to learn and control
This is the LITE version containing only the first five puzzles. If you like this app, then please support me and buy the FULL version.
The FULL version features
- 30 puzzles with different "puzzle styles"
- lots of different animals
Animal Link Up
We have spent more than 1 month working hard together to make it PERFECT. Perfect from each lines of our code to each pixels in our design. Optimize from each bytes of memory to the whole game logic. Test from every little case to the whole game performance. So we think you will love it ^^
★ FREE: now and forever!
★ Fit every screen sizes: supports up to 10 inches tablets.
★ HD quality.
★ 15 levels to play (more is coming).
★ Clean UI.
★ Easy to play.
★ Smallest APK sizes: it means you spend less bandwidth and time to install it.
★ Find 2 cards with the same kind that can be connected in 3 or less than 3 lines to remove them out of board.
★ Remove all cards in time to clear level.
★ If there's no move, game will re-arrange cards automatically.
More from developer
Bible Trivia
Profile info optional, just save a Profile and play for Free!
Also check out my "Bible Quiz - Who Am I?" Android app.
Updated for gingerbread and jellybean.
Bible Quiz - Who Am I?
Personal info optional, just save a Profile and play for Free!
US History Quiz
Personal info optional, just save a Profile and play for Free!
November 2012 update for compatibility with nearly all Android devices.
Movie Trivia
Game options allow you to play games with 10, 20, 50, or unlimited number of questions. Create a profile to save your score to the online leaderboard.
To explore more trivia or submit questions/requests, please visit www.AZTrivia.com
Sports Trivia
Personal info optional, just save a Profile and play for Free!
TV Trivia
Please visit www.AZTrivia.com to see our other trivia games or to submit questions or requests.
Who Sings It? Country Hits
Personal info optional, just save a Profile and play for Free!
June 2014 Update for Kitkat.
November 2012 update for compatibility with nearly all Android devices.
Country Music Trivia
Kenny Chesney, Tim McGraw, Carrie Underwood, Taylor Swift, Little Big Town, Lady Antebellum, Keith Urban, Toby Keith, Reba McEntire, The Dixie Chicks, Garth Brooks, Blake Shelton, Luke Bryan, Chris Young, Faith Hill, Brad Paisley, Shania Twain, Miranda Lambert, Trace Adkins, Jason Aldean, Sunny Sweeney, Alan Jackson, The Band Perry, Jessie James, Alison Krauss, Big & Rich, Brooks & Dunn, Julianne Hough, Jimmy Wayne, Lonestar, Rascal Flatts, LeAnn Rimes, Martina McBride, Deana Carter, and Trisha Yearwood.
Submitting personal info is optional, just save a Profile and play for Free!
World History Quiz
Personal info is optional, just save a Profile and play for Free!
Random Trivia
Random Trivia quiz game will test you on more levels than some people can handle: History, Literature, Music, Sports, Movies, Math, Food, TV, Technology, Animals, Geography, Art, Science, Religion, Mythology, Games, Government, and life in general.
Personal info is optional, just save a Profile and play for Free!
Recent update for compatibility with nearly all Android devices.
Music Trivia
Trivia for Kids
Personal info optional, just save a Profile and play for Free!
US Civil War Quiz
Personal info optional, just save a Profile and play for Free!
1990s TV Trivia
Submitting personal info is optional. Just save a profile and play for free!
Football Trivia
Submitting personal information is optional. Just save a profile and play for Free!
Science Quiz
Game options include either 10, 20, 50, or unlimited-question games, plus a "until 5 errors" game.
Please visit our website at www.AZTrivia.com to submit new questions, give feedback, or ask for support.


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ResultsFound: 51 on Global Tech
Computerization, atomization, crowdsourcing and the new economics of employment
2014 research review on how technology will increasingly break down labor into component parts and related economic and employment outcomes.
How "good enough" technology can stifle innovation
2015 essay on how early adoption of technology can stifle later innovation, by Ethan Zuckerman, director of the Center for Civic Media at the Massachusetts Institute of Technology.
Internet and communications technology: Global energy consumption trends and challenges
2013 review of research and article in the journal Science on the global energy consumption of Internet and communications technology.
When the town square is online, power lies with the people: Research brief
2014 article from the University of Copenhagen on how, when public space meets common knowledge, power can shift from established authority to the people
Multitasking, texting and distracted driving: Researchers discuss cognitive effects and risks
Researchers from Kentucky University, West Virginia University, Harvard and Stanford discuss the risks of using mobile devices while driving and the impact of multitasking on how we process information.
Effects of skilled immigration on U.S. employment
2013 study from Harvard, Wellesley and Johns Hopkins Universities on the varied effects of skilled immigration on employment and native workers.

subset: commoncrawl


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morning jazz
Interview - Frank Foster with Gary WalkerSubmitted by jjackson on Thu, 2008-03-13 11:49
Morning Jazz Host Gary Walker spoke with Frank Foster this morning.
Click here to listen to the interview.
And did you miss our IAJE coverage of the ASCAP Commissions, honoring Uncle Frank?
Gary Cleanhead Walker and David Fathead NewmanSubmitted by jjackson on Fri, 2008-01-25 15:39
David "Fathead" Newman, the legendary Texas-born saxophonist and long-time Ray Charles bandmate, is spending four nights this weekend at Iridium Jazz Club. Many of his good friends will join him onstage for an early celebration of his 75th birthday. Fathead was Paul Schaefer's guest on the David Letterman show earlier this week. And he was Gary Walker's guest on WBGO's Morning Jazz show today.


text:
Community Status Updates
It will never fail to amaze and confuse me that people can sit still and watch a tennis matchToday, 12:13
Quitongo's Left Peg
Hope Solo is bae.Today, 00:51
Rod PetrieA 'hatchet man' - she displays this off the pitch too.
Today, 01:08
Bobby SkidmarksHope Solo's massive blurt.
Today, 07:28
What a song that shut up and dance with me is btw! Gets the top tapping💃Yesterday, 20:47
Holmes 1970
Welcome to our world Livvy Hawrylkiw #Gorgeous !!! Well done Faye #TopMum !!! http://t.co/psqCaysVa2Yesterday, 18:45
RT @getinthesea: WHERE'S 'A' GONE THEN? OFF HOME AFTER HE REALISED YOU LOOK LIKE A PACK OF TWATS? GET IN THE FUCKING SEA http://t.co/mU06b9…Yesterday, 16:43
RT @officialEKFC: EK happy to announce the signing of Ex-Stranraer player Lewis Kinnaird. The midfielder becomes EK's 5th signing of the se…Yesterday, 14:41
RT @BBCSport: Jonny Bairstow and Tim Bresnan rewrite the record books as Yorkshire score 557-6 v Durham. http://t.co/8wMK0GmEOQ http://t.co…Yesterday, 06:33
Checked in to the hotel, buzzing to get to gusto's though, always a decent meal!Jul 04 2015 18:21
joseph anton
I posted 4 photos on Facebook in the album "Hihland Dinners" http://t.co/mfEq00gqgtJul 04 2015 15:18
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posters, paintings posters, all posters, mother and newborn child posters, kathy braud posters, kathy posters, original posters, watercolor posters, portrait posters, portraiture posters, nature posters
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We use acid-free paper with archival inks to guarantee that your posters last a lifetime without fading or loss of color. All posters include a 1" white border around the image to allow for future framing and matting, if desired.
Posters ship within 3 - 4 business days in durable cardboard tubes.
As a sunbeam illuminated the room, I suddenly spotted this wonderful warm glow. The bright red and orange woven throw over my art supplies was reflecting on my precious models of youth, mother and newborn. I grabbed my camera and snapped some quick references. Who would guess the enjoyable mirror effects of reflection seen on skin and clothes? Red was reflecting color, over and over, toward everything facing that direction. This wonderful colorful watercolor then evolved. I feel the color red also carries a real punch of emotional content. Features: Top 100 Colorful Artworks using 5 or more colors 10/24/2014 Loving the Color Red 3/08/2013 Artwork Sold 3/06/2013 Artists California 3/04/2013
scroll down For me, Art has been a lifelong journey of creativity � from using a sewing machine to expanding my wardrobe, to remodeling our century old home while raising our children and practicing nursing and, finally � watercolor painting, an activity to counteract my empty nest syndrome. When I realized this medium could capture the essence of a mood or memory or describe a pleasure, I fell in love with watercolor! Over the years I have enjoyed my ventures into all kinds of subject matter, locations and opportunities to paint and exhibit. I have experienced wonderful people at art fairs and events in our 4 state area. I think there is power in the art we fashion, and this energy can be...
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Philadelphia Union
The Philadelphia Union Academy U-18 team played their first game of the 2015 US Soccer Development Academy playoffs today, facing off against the number one seed in the tournament, the Montreal Impact.
The starting lineup presented by the Union was similar to the one that was seen last week in their warm-up game against Reading United A.C. The team set up in a 4-1-4-1 lineup, with Sebastian Elney up top and Cameron Keys in goal.
The game was tight for both teams until the Impact managed to score in the 30th minute. They then score again in the 37th minute after they got a head to a corner kick. The score remained 2-0 going in to the half, with possession being split nearly 50-50. The game continued to be played close until the 70th minute when Derrick Jones came onto the field as a substitute.
After Jones was subbed on, the Union began to attack in full force, throwing everything they had at the Impact. After a succession of chances, the Union finally scored off of a Sebastian Elney free kick to make the score 2-1 with only stoppage time remaining.
Now, with a chance of getting a draw, the Union turned it up to a gear that they have rarely shown before and hammered the Impact until they finally made a mistake and conceded a penalty. Jones stepped up and slotted the ball past the keeper, leveling it up at 2-2. The referee blew his whistle shortly after kickoff.
This is a huge win for the U-18 team as they managed to get a draw against the toughest team in their group. This gives them hope to make it out of the group stage, as only the winner can advance to the quarterfinals.
The Union U-18's had previously lost to the same Montreal team early May, losing 4-1.
The Union play the LA Galaxy for the only time this season at 10:30 tonight. Here is our lineup:
ST: C.J. Sapong, MLS start No. 74, Union start No. 5
LAM: Andrew Wenger, MLS start No. 53, Union start No. 35
CAM: Cristian Maidana, MLS start No. 34, Union start No. 34
RAM: Zach Pfeffer, MLS start No. 9, Union start No. 9
LDM: Brian Carroll, MLS start No. 308, Union start No. 120
RDM: Vincent Nogueira, MLS start No. 40, Union start No. 40
LB: Sheanon Williams, MLS start No. 137, Union start No. 137
CB: Richie Marquez, MLS start No. 6, Union start No. 6
CB: Maurice Edu, MLS start No. 84, Union start No. 84
RB: Ray Gaddis, MLS start No. 95, Union start No. 95
GK: Brian Sylvestre, MLS start No. 7, Union start No. 7
Bench: John McCarthy, Raymond Lee, Ethan White, Fabinho, Fred, Jimmy McLaughlin, Antoine Hoppenot
Career Stats vs. LA
C.J. Sapong (5 GP, 3 GS, 0 G, 0 A)
Andrew Wenger (3 GP, 1 GS, 0 G, 0 A)
Cristian Maidana (0 GP, 0 GS, 0 G, 0 A)
Zach Pfeffer (1 GP, 0 GS, 0 G, 0 A)
Brian Carroll (19 GP, 18 GS, 0 G, 0 A)
Vincent Nogueira (1 GP, 1 GS, 0 G, 0 A)
Sheanon Williams (6 GP, 6 GS, 0 G, 0 A)
Richie Marquez (0 GP, 0 GS, 0 G, 0 A)
Maurice Edu (4 GP, 4 GS, 0 G, 0 A)
Ray Gaddis (2 GP, 2 GS, 0 G, 0 A)
Brian Sylvestre (0 GP, 0 GS, 0 G, 0 A)
Here is the team's injury report for this week:
|Sebastien Le Toux
|Left knee MCL sprain
|Mike Lahoud
|Right quad strain
|Ferndando Aristeguieta
|Left fibular contusion
|Conor Casey
|Left quad strain
The only new addition to the injury report is Le Toux who was injured after being subbed on in the U.S. Open Cup game on Tuesday against the Rochester Rhinos.
The Philadelphia Union U16 Academy team handed the FC Continental U18s a 4-0 drubbing this afternoon in preparation for the USSDA playoffs next week.
After the game, head coach Jeff Cook was happy with his team's performance and excited for the upcoming tournament.
"The main objective today was preparation for next week. We haven't played a game since June 6 when the academy season ended so we wanted to get back into competing and preparing for a game…so I was pleased with how the guys approached the game. It's going to be 3 good teams and we're going to have to be very intensely focused on the first game. FC West Chester have made the playoffs and they're a good club from suburban New York. We've seen some tape on them. They have a very good striker we're going to have to control, and we'll have to make good on our chances to score. We're a good team going forward, so if we can maximize our chances it'll give us a good chance to win."
FC Continental played conservatively from the onset, holding a deep line and rarely pressuring the Union backline in their own third.
Philadelphia spent the opening moments cycling the ball and probing the Continental backline. Despite sustained pressure, they struggled to put together the final pass, save for a shot off the post in the first 15 minutes.
FC Continental grew into the game and put together a few spells of possession late in the first half, but left themselves vulnerable to a number of Union counters. One such counter caught them out as Joe Dezart stripped a Continental attacker in front of his own box. He quickly collected the ball and sent it forward to Justin McMaster. McMaster then took off down the field and played a through ball to a streaking Jack Skahan who blasted his breakaway chance into the upper corner of the net.
McMaster collected his second assist soon after, as his entry pass was badly misplayed by the Continental keeper and swept up by Tiger Graham, who put it through the keeper's legs and into the net in the waning minute of the half.
The last bit of action occurred in the Union box, as a Continental attacker found space from 25 yards out and sent a low hard drive in towards Andrew Verdi's goal. The shot had pace but was struck right at Verdi, who did well to smother it with multiple Continental attackers lurking for the rebound.
Head coach Jeff Cook put out a new 11 for the second half. The first action occurred only minutes in, as replacement keeper Justin Bajek.
The Union nearly struck once again as Raheem Taylor-Parkes narrowly missed a low angle shot to the far post.
Taylor-Parkes narrowly missed once again following some brilliant dribbling by Anthony Fontana. Fontana put together two spin moves before playing Raheem through, but his breakaway chance was well saved by the onrushing keeper.
After relentless pressure, the Union found their 3rd in bizarre fashion as a Dawson McCartney corner kick somehow eluded everyone and found its way into the net.
The biggest scare of the match occurred late on, as Justin Bajek whiffed on a Continental corner. Fortunately for him, Evan Godfrey was there to clear. It was one of several key interventions that Godfrey made during the half, as he put in a solid shift at center back.
The last goal was scored late on, as Kalil Elmekhar tore down Continental's left flank and played a low cross into Juan Infante, who sent touched down the ball and struck a half volley off of the crossbar and into the net.
Cook also spoke volumes about the Union Academy program and how far it has come in only two years of existence.
"We're coming to the end of our second year as a full time academy program and our objective is to produce outstanding players from our home territory that can eventually represent the club at PPL Park as professionals. We have about 75 players involved in the program now, of which 25 are in residency. Of that group, there's another 50 that are students at YSC Academy. So it is a comprehensive full-time program. It's 10 months so it's very demanding and the staff is working absolutely tirelessly to try and accelerate the development of the most elite players in our region. We're excited about the future and we feel that there are a lot of indicators that say we're making good progress."
Today, on the Philadelphia Union's practice field, the Philadelphia U-18 academy team fell 2-1 to Reading United A.C., the Union's player development club.
Multiple players from Reading have previously featured in the U-18 academy team including University of Virginia star Darius Madison and Georgetown University's Brett Campbell.
The game started well for the U-18's, scoring in the first five minutes thanks to Sebastian Elney, who will play for the University of Maryland next year. He was able to make the most of a ball put into the box and put it in the back of the net despite it bouncing around after he received it. Elney's goal was made more impressive by the fact that he was playing with a large foam covering on his wrist due to a recent sprain.
The rest of the first half went about as well as they could have hoped for, with the team alternating their defensive strategy between high pressure and low pressure. The first 15 minutes saw the players chasing down every ball and not letting the Reading players get more than two touches. This worked well as it caused Reading some early issues and lead to the goal being scored. The next 15 were dedicated to a low pressure approach, which they executed well. The final minutes of the half saw them switch back to a high pressure system in order to try to get another goal.
"I thought our work on the pressing scheme came off quite good today, and it also showed we still have some work to do with it," head coach Peter Fuller said. "I thought the guys did a good job, particularly the first group, and overall. The first group, the first 45 minutes I thought was excellent. Going forward into next week our focus is on getting guys sharper and getting better, getting guys more and more comfortable with themselves and making sure out speed of play is right because all three teams in our group will force us to play quickly."
Fuller then made a full line change at the half, sending out all eleven players who were on the bench for the first half, including Yosef Samuel and Derrick Jones.
The second half did not go nearly as well for the team as they struggled to press the same way that the first half team was able to. Being unable to press lead to Reading having much more time on the ball and were able to pick out passes and eventually place a cross into the box which was headed home on the far post.
Will Campbell, a University of North Carolina commit, was subbed on half way into the second half after playing in the first half. At this time, Samuel was moved into a center-forward position in a switch from the left wing. Neither of these two changes worked for the team as Reading scored a second goal, this time on a well-balanced counterattack.
In his post game talk with the players, Fuller said that he has no favorites on the team and will put the best 11 players out there that can best represent the club.
Fuller will pick the 18 players who will travel to the US Soccer Development Academy Playoffs in Indiana on Friday. They face the U-18 teams for the Montreal Impact, the LA Galaxy and Kendall SC in group play which begins on Tuesday, June 23.
Today was a great day for practice, with the sun staying out for long periods of time while the breeze came in off of the water.
Practice today was a relatively easy day, especially for yesterday's starters, most of whom play 120 minutes. The starters did some warm ups before ending early with some stretching and conditioning.
Those who didn't start or are coming off of injuries proceeded to play small sided games with varying tasks. One of the people who returned to practice today was Conor Casey, his first game action since re-injuring his hamstring playing the New York Red Bulls.
Practice consisted mostly of various versions of 4v4. The first version was a normal 4v4 where Conor played offensively for both teams as an extra man.
Those teams broke down like this:
Brian Carroll, Jimmy McLaughlin, Ethan White, and Raymond Lee in gray
Sheanon Williams, Fred, Eric Bird, and Antoine Hoppenot in orange
The game then expanded to a half field where goalies were involved. This was a 3v2 set up where Antoine played offense on one end and Casey played offense on the other end. Everyone else were in teams of two and they rotated between moving forward against another team of two or defending against one.
Practice ended with a normal 4v4 with the exception of Conor and Antoine not allowed on to the defensive half of the field for their respective teams. Both Brian Sylvestre and Andre Blake looked good in goal.
After practice, Lee, McLaughlin, and Bird got some extra work in on receiving crosses. Antoine and Sheanon did extra conditioning work while Andre and Brian did some extra goal kicks.
The Union held their weekly press conferece today, pushed ahead from the usual Wednesday spot due to the US Open Cup game agaisnt the Rochester Rhinos tomorrow. This week, John McCarthy was the player giving his thoughts on the upcoming week. Here are some of his highlights:
Jim how do you approach the lineup for a game like this?
Yeah, it's a good team coming-in in Rochester. I've watched a bunch of tape on them; they don't concede a lot of goals – they've only given up four and scored 16, they're 8-0-4 so they haven't been beat this year. We're going to have to be on our game – can't take them lightly. They're a well-coached, organized team and they have a couple weapons. Fortunately, the Dos Santos kid – the striker – is suspended from the Harrisburg game. I don't think they'll press us in our building, but maybe they do, it'll be something we're ready for but I expect them to sit back a little bit, give us possession, and make us really have to break them down. Which will be a difficult task because they have some big bodies in there. They have guys that are MLS in one or two years and they're guys with a chip on their shoulder – lot of familiar names if you go through their roster, a bunch of guys that are playing with edge right now and winning. It'll be a tough task in terms of how we look at our squad – we're going to have to field a team that is up to the task and without going into too many details into my lineup, it's going to be a group that will go out and compete and a group that sets us up knowing that we do have a busy stretch. So there could be some younger guys that see minutes.
Those early games in the US open cup last year – especially against Harrisburg – definitely weren't a walk in the park. A lot of the guys who are on this team this year know that – are they taking that into account?
For sure, yeah. I've been warning them as much as possible all week. The early round games are in a lot of ways the toughest – because if you run into a Cosmos, or Rochester, this is a chance for them to knock off one of the higher league in terms of standings – they want to impress and say they belong in MLS as a team, as an individual. So that parts challenging – getting the guys motivated. The key is playing at a tempo and a speed that they're not maybe used to – when MLS games get ramped up, it is faster, it is a stronger league, but there is any given day a team that can come in here and give you a tough time. Last year you saw it with Harrisburg and the Cosmos – those were our two toughest games – because they are still good teams, they both can play, the guys get paid to play, so they are professionals, as well. It's challenging to get our guys to be ready for it, you see it so often though, these games become tricky, and MLS teams are going to lose in this round. That's a fact. Someone is going to go down, it happens every year, and you have to do your best to prevent it. The advantage is we have a home game, we don't have to travel which is good, and we have a big nice field we can play on. So we have to take care of business, it's up to us to execute and go on the field and put together a good performance on a Tuesday night.
Does it help at all, having a guy like John (McCarthy) who understands the other side and the mentality that Rochester is going to bring into this?
Yeah, for sure. He helps in the scouting, he helps in all the little things. So again, he's a guy who has been on both sides – he can speak to how good of a team this Rochester group is – they weren't as strong last year, but this year they have come in and really separated themselves from a lot of the other teams in the league and are doing really well. Again, we're not going to have a let down or be caught off guard or underestimate them in any way. John has played both sides, obviously he wants to get a win now for Philadelphia.
Practice today took place in conditions similar to what you would find in the Sahara desert. It was hot and dry, unusual considering the practice fields are 500 feet from the water and they usually get a breeze blowing inland.
Missing from practice today were Eric Ayuk, Jimmy McLaughlin, Eric Bird and Raymond Lee. All four went to go play with the Harrisburg City Islanders as they take on St. Louis FC in St. Louis.
Practice consisted mostly of a seven-on-seven drill where the two teams playing focused on possession and smart passing. For this version of seven-on-seven, the teams had to shoot into small goals placed around the field. Both Curtin and assistant coach Mike Sorber could be heard correcting individual players and any mistakes that were made.
The team then switched over to full-size goals for the last 15 minutes of practice, with John McCarthy, Andre Blake and Brain Sylvestre rotating in and out. Chaco looked particularly good today, playing great balls into the middle with both feet and finishing with a lot of technique.
Yosef Samuel joined the team for practice today. Samuel is a member of the Union's U-18 Academy team.
Today's practice was HOT with temperatures on the field reaching above 95 degrees. Players were allowed to get a late start today after the friendly against Reading United yesterday, stating practice at 11 as opposed to 10.
Because it was so hot out, players were allowed to take it easy, especially in the early stages of practice when they do their strength and conditioning drills. Water breaks were frequent but not so frequent that they disrupted the flow of practice.
Michael Lahoud was back in practice today, fully participating for the first time since his injury against Toronto FC in early May. He looked very good for someone who hasn't practiced in a month, and even stayed late to work on his passing and cutting.
The players did a lot of one touch possession passing, playing a 9-on-2 game where the nine outside players one touched passes to each other while trying to avoid the two who were running around in the middle trying to intercept the ball.
While they did that, the goalkeepers (all three of them) worked on their reflexes and their positioning on reflex saves. Andre Blake looked better today than he did all last week now that he has had a full week of practice under his belt.
Another familiar face was back in practice today as well, if only for a week. Danny Cruz was with the team today in practice, working to stay fit while his current team, FK Bodo/Glimt of Tippeligaen, is on international break. He is in town to visit his fiancé.
Practice ended with the team doing three separate line drills that had them work on their footwork, passing, and their first touch on the ball. All three lines were then directed towards goal where the three Union keepers tried to stop their shots.
Week 14 wasn't quite what Union fans envisioned, especially after a 3-0 triumph over Columbus Crew SC on Wednesday, but some Union players received some well-deserved accolades for last week's performances.
Start with forward C.J. Sapong, who scored a pair of goals this week against Columbus and New York City that earned him a nod on MLSsoccer.com Team of the Week. He now has four goals on the year and is third in MLS in goals scored per minute played.
The recent run of form has defender Sheanon Williams making some headlines. Another strong week for the resurgent right back placed him on Goal.com's Team of the Week.
Goalkeeper Brian Sylvestre posted his remarkable third clean sheet of his young career on Wednesday against Crew SC. He kept keep the game scoreless with a wonderful save on Aaron Schoenfeld in the first half. That earned him a nomination for the Save of the Week.
And some power rankings. The Union are No. 17 at Bleacher Report, No. 18 at ESPNFC and at MLSGB and finally, No. 20 at MLSsoccer.com.


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text:
Salmon Ring with Cucumber Sauce
29 Jan 2011
|2 , slightly beaten
|Canned salmon
|16 Ounce, drained, flaked (1 Can)
|Dry bread crumbs
|1 Cup (16 tbs)
|1⁄2 Cup (8 tbs)
|Chopped celery
|1⁄4 Cup (4 tbs)
|Chopped green pepper
|2 Tablespoon
|Chopped green onion
|2 Tablespoon
|Lemon juice
|1 Tablespoon
|1⁄2 Teaspoon
|Cucumber sauce
|1⁄2 Cup (8 tbs)
In medium bowl, combine all ingredients; mix well.
Spoon in 9" baking ring, or make your own by placing a 4 or 5-inch high glass, open end up, in a 2-quart casserole.
TO HEAT BY TIME Cover with wax paper.
Set Power Select at HIGH for 5 minutes and MEDIUM-LOW for 4 minutes.
TO HEAT BY INSTA-MATIC Cover completely with plastic wrap; heat on COOK 4.
Let stand, uncovered, 5 minutes.
Loosen edges with spatula before unmolding.
Recipe Summary
Difficulty Level:Very Easy
Course:Main Dish
Rate It
0 Comments
Salmon Ring With Cucumber Sauce Recipe


text:
Inhibitors of cGMP-specific PDE are useful in the treatment of acne.
1. A method of treating acne in a patient with acne, comprising administering to the patient a physiologically effective amount of a cGMP-specific PDE inhibitor.
This application is a continuation in part of U.S. patent application Ser. No. 09/239,840 filed Jan. 29, 1999, now U.S. Pat. No. 6,025,394, which is incorporated herein by reference.
Acne is a skin disease that often scars those afflicted, and can afflict patients at young ages—typically teen years—when their self-images are the most sensitive. The scarring is commonly permanent even if the condition is treated with medications. Some patients experience symptoms well into their adult years.
Acne is believed to be caused typically when the sebaceous glands become clogged due to skin cell debris and an excess of a specific type of skin bacteria. Sebaceous glands are located within the dermis layer of the skin along the hair shaft. Keratin and other chemicals associated with the skin can clog the hair shaft and the sebaceous gland. The bacteria, Propionibacterium acnes (P. acnes), which is always present, multiplies to a much greater degree when the sebaceous glands are clogged because the bacteria prefer an anaerobic environment, which is present when the glands become clogged.
P. acnes produces a lipase enzyme that hydrolyzes triglycerides of the sebaceous gland into free fatty acids. The fatty acids along with bacterial proteins and keratin can irritate the skin tissues. This may lead to an inflammatory response and the formation of an acne lesion.
Although the exact cause of acne is unknown, hormones, genetics, and environmental factors all seem to play a role. Androgens, such as testosterone, play an important role in the development of acne lesions. This is evidenced by the correlation between the onset of puberty and the development of acne, and the fact that acne is generally more severe in males than in females.
The type of acne treatments currently recommended depend on the type and the severity of the acne. A few over-the-counter medications (e.g., benzoyl peroxide and salicylic acid) can be used for mild forms of acne, but are ineffective for the moderate and severe cases of acne.
Tretinoin (Retin-A) is often used in combination with or as a replacement for treatment with benzoyl peroxide. Tretinoin is a derivative of vitamin A and is available for topical use. It acts to prevent comedone formation through its anti-keratinization effect. The side effects of tretinoin include heightened sensitivity to exposure to sunlight and local irritation.
Topical antibiotics are sometimes used for treatment of patients with mild to moderate inflammatory acne, but are ineffective against more severe inflammatory acne. To the extent antibiotics have effects against more severe (i.e. inflammatory) forms of acne, the antibiotics must be systemically administered, usually at high doses (e.g., 500 to 2,000 mg/day) initially followed by maintenance doses (e.g., 250-500 mg/day). The most commonly prescribed antibiotic is tetracycline, but erythromycin and minocycline are also used. Such antibiotics, particularly at high doses can lead to side effects including gastrointestinal symptoms such as nausea, vomiting, abdominal pain, diarrhea, rashes, and other allergic reactions. Tetracyclines also can cause fetal harm if used during pregnancy.
Hormone therapy is another approach to treatment of acne based on the involvement of androgens in the development of acne. Estrogen therapy can be effective, but its usefulness is particularly limited in males by side effects such as gynecomastia, suppression of the testes, and uncertain effects on skeletal growth.
Isotretinoin (ACCUTANE) has been used in the treatment of severe nodulocystic acne. ACCUTANE therapy can lead to improvement in acne and can, in some cases exhibit the potential to prevent most permanent scarring from inflammatory acne. The severe side effects of ACCUTANE, however, are often prohibitive. Dry skin, dry eyes, headache, hair thinning, musculoskeltal pain, and other complications may result from treatment with ACCUTANE. Due to its teratogenicity, ACCUTANE should not be used by women who are pregnant or might become pregnant.
Thus, to date, there is typically a trade-off between efficacy and side effects, particularly in the treatment of more severe forms of acne. Accordingly, an effective treatment of acne, particularly its more severe forms, with clinically insignificant side effects is desired.
This invention relates to a method for treating acne by administering to an afflicted patient a therapeutically effective amount of a cGMP-specific phosphodiesterase ("PDE") inhibitor. With such an inhibitor, acne can be treated with minimal side effects associated with conventional acne medications.
An example of a cGMP-specific PDE inhibitor is a compound of Formula
wherein R1 is independently selected in each instance from the group consisting of hydrogen, halogen, lower alkoxy, hydroxy, lower alkyl, lower alkyl mercapto, lower alkylsulfonyl, lower alkylamino, di-lower alkyl amino, amino, nitro, nitrile, lower alkyl carboxyl ate, —CO2H, and sulfonamido;
R2 is selected from the group consisting of hydrogen and lower alkyl;
R3 is selected from the group consisting of hydrogen, lower alkyl, hydroxy, and amino;
R4 is selected from the group consisting of -COM and CH2OH wherein M is selected from the group consisting of hydroxy, substituted lower alkoxy, amino, alkylamino, dialkylamino, N-morpholino, hydroxyalkylamino, polyhydroxyamino, dialkylaminoalkylamino, aminoalklyamino, and the group OMe, wherein Me is a cation;
R5 is an alkyl sulfonyl; and n is an integer from 0 to four; or a pharmaceutically acceptable salt thereof.
Preferred compounds within the scope of Formula I include those wherein R1 is halogen; n is 1; R2 is lower alkyl; M is hydroxy; and R3 is hydrogen or lower alkyl. More preferred compounds useful in the therapeutic method of this invention include those wherein R1 is 5-fluoro; n is 1; R2 is methyl; M is hydroxy; and R3 is hydrogen.
The most preferred compound of Formula I for treating acne is exisulind. The chemical formula of exisulind is (Z)-5-fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]indene-3-yl acetic acid. The cGMP-specific PDE inhibitory characteristics of exisulind are reported in U.S. Pat. No. 5,858,694. Clinical studies have demonstrated that exisulind is generally well tolerated by patients, has no reported clinically relevant side effects, and can be used safely by humans.
As used herein, the term "acne" includes the various known types of acne and related skin disorders, including acne vulgaris, acne conglobata, acne fulminans, pyoderma facaile, acne keloidalis, chloracne, and steroid acne. The most common form of acne is acne vulgaris, which is characterized by two types of lesions, inflammatory and noninflammatory. Noninflammatory lesions include open comedones (blackheads) and closed comedones (whiteheads) and are characterized by a lymphocytic infiltrate. Inflammatory lesions can be superficial or deep. Superficial inflammatory lesions include papules and pustules, and deep inflammatory lesions consist of cysts and nodules. Inflammatory lesions include those characterized by rupture of the follicular wall and aggregation of neutrophils and mononuclear cells. Acne vulgaris and the other forms of acne which may be treated by administering a therapeutically effective amount of a compound of Formula I are described in more detail in Principles and Practice of Dermatology, Chapter 70: Acne and Related Disorders, W. Mitchell Sams, Jr. and Peter J. Lynch eds., 1990, which is incorporated herein by reference.
As used herein, the term "alkyl" refers to straight, branched or cyclic alkyl groups and to substituted aryl alkyl groups. The term "lower alkyl" refers to C1 to C8 alkyl groups.
The term "lower alkoxy" refers to alkoxy groups having from 1 to 8 carbons, including straight, branched or cyclic arrangements.
The term "lower alkylmercapto" refers to a sulfide group that is substituted with a lower alkyl group; and the term "lower alkyl sulfonyl" refers to a sulfone group that is substituted with a lower alkyl group.
The term "lower alkyl carboxylate" refers to a carboxylate group that is substituted with a lower alkyl group.
The term "pharmaceutically acceptable salt" refers to non-toxic acid addition salts and alkaline earth metal salts of the compounds of Formula I. The salts can be prepared in situ during the final isolation and purification of such compounds, or separately by reacting the free base or acid functions with a suitable organic acid or base, for example. Representative acid addition salts include the hydrochloride, hydrobromide, sulfate, bisulfate, acetate, valerate, oleate, palmatate, stearate, laurate, borate, benzoate, lactate, phosphate, tosylate, mesylate, citrate, maleate, fumarate, succinate, tartrate, glucoheptonate, lactobionate, lauryl sulfate salts and the like. Representative alkali and alkaline earth metal salts include the sodium, calcium, potassium and magnesium salts.
It will be appreciated that certain compounds of Formula I can possess an asymmetric carbon atom and are thus capable of existing as enantiomers. Unless otherwise specified, this invention includes such enantiomers, including any racemates. The separate enaniomers may be synthesized from chiral starting materials, or the racemates can be resolved by conventional procedures that are well known in the art of chemistry such as chiral chromatography, fractional crystallization of diastereomeric salts and the like.
Compounds of Formula I also can exist as geometrical isomers (Z and E); the Z isomer is preferred.
As noted above, preferred compounds within the scope of Formula I include those wherein R1 is halogen; n is 1; R2 is lower alkyl; M is hydroxy; and R3 is hydrogen or lower alkyl. More preferred compounds useful in treating acne include those wherein R1 is 5-fluoro; n is 1; R2 is methyl; M is hydroxy; and R3 is hydrogen.
The most preferred compound of Formula I for treating acne is exisulind, (Z)-5-fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]indene-3-yl acetic acid.
The term "cGMP-specific PDE" refers to enzymes such as PDE5 and any of its isoforms that exhibit cGMP-specific hydrolytic enzyme activities and high affinity cGMP binding.
In clinical studies for uses other than acne, it has been demonstrated that exisulind can be safely administered to human patients. Studies with adult patients with intact colons received exisulind at a dosage of 400 mg/day, and patients who had previously undergone a colectomy received exisulind at a dosage of 600 mg/day. In another study with adult patients, the patients received 500 mg/day of exisulind. In a study involving pediatric patients, the dosage of exisulind used ranged from 250 to 350 mg per day.
In these studies, exisulind is generally well tolerated in patients. There have been no clinically relevant side effects reported. The maximum tolerated dose (MTD) was determined to be 600 mg/day in patients with colectomies, and 400 mg/day in the group with intact colons. These elevations were completely reversible on stopping the drug. Additionally, after a patient with elevated liver enzymes stops receiving the drug for approximately one week, the patient can then safely resume treatment at the same or a lower therapeutic dose, i.e. the dosages mentioned above. The elevations seem to be dose related and have been seen mostly at doses above the maximum tolerated dose. There is one group of 18 patients which received exisulind at a daily dose of 600 mg/day for an extended period of time with no such clinically significant side effects. Thirteen of those patients received exisulind for over three years.
Other examples of cGMP-specific PDE inhibitors include MY-5445, dipyridamol.
Additional compounds that may be useful in the practice of this invention include those disclosed in GB 2 063 249 A, GB 2 063 249 A, EP 0 607 439 A1, U.S. Pat. No. 4,101,548, U.S. Pat. No. 4,001,238, U.S. Pat. No. 4,001,237, U.S. Pat. No. 3,920,636, U.S. Pat. No. 4,060,615, WO 97/03985, EP 0 607 439 A1, U.S. Pat. No. 4,101,548, U.S. Pat. No. 4,001,238, U.S. Pat. No. 4,001,237, U.S. Pat. No. 3,920,636, U.S. Pat. No. 4,060,615, WO 97/03985, EP 0 395 328, U.S. Pat. No. 4,209,623, EP 0 395 328, U.S. Pat. No. 4,209,623, U.S. Pat. No. 5,354,571, EP 0 428 268 A2, U.S. Pat. No. 5,354,571, EP 0 428 268 A2, 807,826, U.S. Pat. No. 3,031,450, U.S. Pat. No. 3,322,755, U.S. Pat. No. 5,401,774, 807,826, U.S. Pat. No. 3,031,450, U.S. Pat. No. 3,322,755, U.S. Pat. No. 5,401,774, U.S. Pat. No. 5,147,875, PCT WO 93/12095, U.S. Pat. No 5,147,875, PCT WO 93/12095, U.S. Pat. No. 4,885,301, WO 93/07149, EP 0 349 239 A2, EP 0 352 960 A2, EP 0 526 004 A1, EP 0 463 756 A1, U.S. Pat. No. 4,885,301, WO 93/07149, EP 0 349 239 A2, EP 0352 960 A2, EP 0 526 004 A1, EP 0 463 756 A1, EP 0 607 439 A1, EP 0 607 439 A1, WO 94/05661, EP 0 351 058, U.S. Pat. No. 4,162,316, EP 0 347 146, U.S. Pat. No. 4,047,404, U.S. Pat. No. 5,614,530, U.S. Pat. No. 5,488,055, WO 97/03985, WO 97/03675, WO 95/19978, U.S. Pat. No. 4,880,810, WO 98/08848, U.S. Pat. No. 5,439,895, U.S. Pat. No. 5,614,627, PCT US94/01728, WO 98/16521, EP 0 722 943 A1, EP 0 722 937 A1, EP 0 722 944 A1, WO 98/17668, WO 97/24334, WO 97/24334, WO 97/24334, WO 97/24334, WO 97/24334, WO 98/06722, PCT/JP97/03592, WO 98/23597, WO 94/29277, WO 98/14448, WO 97/03070, WO 98/38168, WO 96/32379, and PCT/GB98/03712, which are incorporated herein by reference.
Compounds useful in the practice of this invention may be formulated into pharmaceutical compositions together with pharmaceutically acceptable carriers for oral administration in solid or liquid form, or for intravenous, intramuscular, subcutaneous, transdermal, or topical administration, although carriers for oral administration are most preferred.
Pharmaceutically acceptable carriers for oral administration include capsules, tablets, pills, powders, troches and granules. In such solid dosage forms, the carrier can comprise at least one inert diluent such as sucrose, lactose or starch. Such carriers can also comprise, as is normal practice, additional substances other than diluents, e.g., lubricating agents such as magnesium stearate. In the case of capsules, tablets, troches and pills, the carriers may also comprise buffering agents. Carriers such as tablets, pills and granules can be prepared with enteric coatings on the surfaces of the tablets, pills or granules. Alternatively, the enterically coated compound can be pressed into a tablet, pill, or granule, and the tablet, pill or granules for administration to the patient. Preferred enteric coatings include those that dissolve or disintegrate at colonic pH such as shellac or Eudraget S.
Pharmaceutically acceptable carriers include liquid dosage forms for oral administration, e.g., pharmaceutically acceptable emulsions, solutions, suspensions, syrups and elixirs containing inert diluents commonly used in the art, such as water. Besides such inert diluents, compositions can also include adjuvants such as wetting agents, emulsifying and suspending agents, and sweetening, flavoring and perfuming agents.
Pharmaceutically acceptable carriers for topical administration include DMSO, alcohol or propylene glycol and the like that can be employed with patches or other liquid-retaining material to hold the medicament in place on the skin so that the medicament will not dry out.
Pharmaceutically acceptable carriers for intravenous administration include solutions containing pharmaceutically acceptable salts or sugars. Pharmaceutically acceptable carriers for intramuscular or subcutaneous injection include pharmaceutically acceptable salts, oils or sugars.
When used in its acid form, a compound of Formula I useful in the practice of this invention can be employed in the form of a pharmaceutically acceptable salt of the acid. For example, sodium or potassium salts can be obtained by neutralizing with an equivalent base (alkali) metal hydroxide, mesylate or tosylate. When the active chemical is a base, it can be used as an acceptable formulation by neutralizing it with a suitable acid such as hydrochloric acid. Carriers such as solvents, water, buffers, alkanols, cyclodextrans and aralkanols can be used. Other auxiliary, non-toxic agents may be included, for example, polyethylene glycols, antimicrobial agents and wetting agents.
The pharmaceutically acceptable carrier and compounds of this invention are formulated into unit dosage forms for administration to a patient. The dosage levels of active ingredient (i.e., compounds of this invention) in the unit dosage may be varied so as to obtain an amount of active ingredient effective to achieve activity in accordance with the desired method of administration (ie., oral or intravenous). The selected dosage level therefore depends upon the nature of the active compound administered, the route of administration, the desired duration of treatment, and other factors. If desired, the unit dosage may be such that the daily requirement for active compound is in one dose, or divided among multiple doses for administration, e.g., two to four times per day.
The pharmaceutical compositions of this invention are preferably packaged in a container (e.g., a box or bottle, or both) with suitable printed material (e.g., a package insert) containing indications, directions for use, etc.
Examples 1-3 illustrate compounds useful in the practice of the claimed invention. Example 4 describes the clinical results with a 16 year-old patient with acne vulgaris who was treated with exisulind.
(A) p -Fluoro-α-methylcinnamic acid
p-Fluorobenzaldehyde (200 g, 1.61 mole), propionic anhydride (3.5 g, 2.42 mole) and sodium propionate (155 g, 1.61 mole) are mixed in a 1 liter, three-necked flask flushed with nitrogen. The mixture is heated gradually in an oil-bath to 140� C. After 20 hours, the flask is cooled to 100� C. and poured into 8 liters of water. The precipitate is dissolved by adding potassium hydroxide (302 g) in 2 liters of water. The aqueous solution is extracted with ether, and the ether extracts are washed with potassium hydroxide solution. The combined aqueous layers are filtered, acidified with concentrated HCl, and filtered; and the collected solid washed with water, thereby producing p-fluoro-α-methylcinnamic acid which is used as obtained.
(B) p-Fluoro-α-methylhydrocinnamic acid.
To p-fluoro-α-methylcinnamic acid (177.9 g, 0.987 mole) in 3.6 liters ethanol is added 11.0 g of 5% Pd/C and the mixture is reduced at room temperature under a hydrogen pressure of 40 p.s.i.; uptake is 31-32 lbs. (97% of theoretical). After the catalyst is filtered, the filtrate is concentrated in vacuo to give the product p-fluoro-α-methylhydrocinnamic acid that is used without weighing in next step.
(C) 6-Fluoro-2-methylindanone
To polyphosphoric acid (932 g) at 70� C. on the steam bath is added p-fluoro-α-methylhydrocinnamic acid (93.2 g, 0.5 mole) slowly with stirring. The temperature is gradually raised to 95� C., and the mixture is kept at that temperature for 1 hour. The mixture is allowed to cool and added to 2 liters of water. The aqueous layer is extracted with ether, the ether solution washed twice with saturated sodium chloride solution, 5% Na2CO3 solution, water, and then dried. The ether filtrate is concentrated with 200 g silica-gel, and added to a five pound silica-gel column packed with 5% ether-petroleum ether. The column is eluted with 5-10% ether-petroleum ether and followed by TLC to give 6-fluoro-2-methylindanone.
(D) 5-fluoro-2-methylindenyl-3-acetic acid
A mixture of 6-fluoro-2-methylindanone (18.4 g, 0.112 g, mole), cyanoacetic acid (10.5 g, 0.123 mole), acetic acid (6.6 g), and ammonium acetate (1.7 g) in dry toluene (15.5 ml) is refluxed with stirring for 21 hours, as the liberated water is collected in a Dean Stark trap. The toluene is concentrated, and the residue dissolved in 60 ml of hot ethanol and 14 ml of 2.2N aqueous potassium hydroxide solution. 22 g of 8.5% KOH in 150 ml of water is added, and the mixture refluxed for 13 hours under nitrogen. The ethanol is removed under vacuum, water (500 ml) is added, and the aqueous solution washed well with ether, and then boiled with charcoal. The aqueous filtrate is acidified to pH 2 with 50% hydrochloric acid, cooled, and the precipitate collected. In this way dried 5-fluoro-2-methylindenyl-3-acetic acid (M.P. 164-166� C.) is obtained.
(E) 5-Fluoro-2-methyl-1-(p-methylthiobenzylidene)-3-indenyl acetic acid.
5-fluoro-2-methyl-3-indenyl acetic acid (15 g, 0.072 mole) p-methylthiobenzaldehyde (14.0 g, 0.091 mole) and sodium methoxide (13.0 g, 0.24 mole) are heated in methanol (200 ml) at 60 degree(s) under nitrogen with stirring for 6 hours. After cooling, the reaction mixture is poured into ice-water (750 ml), acidified with 2.5N hydrochloric acid, and the collected solid triturated with a little ether to produce 5-fluoro-2-methyl-1-(p-methylthiobenzylidene)-3-indenyl acetic acid (M.P. 187-188.2� C.). U.V. in methanol λmax. 348 mμ (E % 500), 258 (557), 258 (495), 353 (513), 262.5 (577), 242.5. (511).
(F) 5-Fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-3-indenyl acetic acid.
To a solution of 5-fluoro-2-methyl-1-(p-methylthiobenzylidene)-3-indenyl acetic acid (3.4 g, 0.01 mole) in a mixture of methanol (250 ml) and acetone (100 ml) is added a solution of sodium periodate (3.8 g, 0.018 mole) in water (50 ml) with stirring. Water (450 ml) is added after 18 hours, and the organic solvents removed under vacuum below 30� C. The precipitated product is filtered, dried and recrystallized from ethyl acetate to give 5-fluoro-2-methyl-1-(rho-methylsulfinylbenzylidene)-3-indenyl acetic acid. Upon repeated recrystallization upon ethylacetate there is obtained cis-5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-3-indenyl acetic acid, M.P. 184-186� C. U.V. in methanol; λmax 328 (E % 377), 286 (432), 257.5 shldr. (413), 227 (548). Further runs reveal the existence of a second polymorph of cis-5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-3-indenyl acetic acid, M.P. 179-181� C.
(G) 5-Fluoro-2-methyl-1-(p-methylsulfonylbenzylidene)-3-indenyl acetic acid
5-Fluoro-2-methyl-1-(p-methylsulfonylbenzylidene)-3-indenyl acetic acid is prepared by adding sodium methoxide (4.4M in MeOH, 68.5 ml, 0.3 mol) dropwise to a stirred, cooled mixture of 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-3-indenyl acetic acid (100 g, 0.281 mol) in methanol (250 ml) and acetonitrile (500 ml). Sodium bicarbonate (0.56 mol) and hydrogen peroxide (30% in water, 0.56 mol) are added and allowed to react for 18 hours at −10� C. Excess sodium bicarbonate is filtered off, and cooled filtrate (0� C.) neutralized dropwise to pH 7 with 1M hydrochloric acid (350 ml). The resulting product is then filtered and washed with methanol. A thin layer chromatography system to check for purity utilizes chloroform:methyl isobutyl ketone (8:2); the Rf value is 0.21. A tetrahydrofuran/diisopropyl ether combination can be used for product recrystallization. Reaction yield is 89%. (R1=5-fluoro; R2=CH3; R3=hydrogen; R4=COOH; R5=CH3SO2; n=1).
Formula: C20H17FO4S
Molecular Mass: 372.41 g/mol
Melting point: 204-206� C.
1H-NMR [ppm] (DMSO-d6): 2.16 (s,3,—CH3); 3.30 (s,3,—SO2—CH3); 3.59 (s,2,—CH2—C═O); 6.70-7.17 (m,3,ar.); 7.38 (s,1,═CH—); 7.78-8.04 (AB,4,—Ph—SO2—). HPLC (C-18 Column, 50% acetic acid (2%)/50% acetonitrile, 1.5 ml/min): 3.21 min
IR [cm−1] (KBr): 1710 C═O; 1310 S═O; 1180 C—F; 1140 S═O.
α-[1-(p -methylsulfonylbenzylidene)-2-methyl-5-fluoro-3-indenyl]-propionic acid is prepared by the similar procedures known in the art.
5-fluoro-2-methyl-1-(p-methylsulfonylbenzylidene)-3-indenyl acetic acid is prepared by the procedure of Example 1, and converted to the methyl ester derivative by the following procedure. Sodium methoxide (4.4M in methanol, 1.36 ml, 0.006 mol) is added to a stirred cooled solution (0� C.) of 5-fluoro-2-methyl-1-(p-methylsulfonylbenzylidene)-3-indenyl acetic acid (1.04 g, 0.0028 mol) in methanol (5 ml) and acetonitrile (10 ml). After 30 minutes, the reaction mixture is dropped into concentrated hydrochloric acid (50 ml) and extracted with methylene chloride (3�25 ml). The organic layer is extracted with saturated sodium bicarbonate (3�25 ml), dried with sodium sulfate, and concentrated in vacuo. The resulting oil is crystallized from tetrahydrofuran/hexane to yield 0.2 g of the desired compound. The melting point is 165-166� C. (R1=5-fluoro; R2=CH3; R3=hydrogen; R4=COO CH3; R5=CH3SO2; n=1).
Other methyl esters of compounds of Formula I useful in this invention can be prepared in a similar fashion.
(A) Methyl-5-fluoro-2-methyl-1H-3-indenylacetate
Nitrosomethylurea (99.5 mmol) is added in portions to a cold (0� C.) mixture of aqueous 50% KOH (50 ml) and diethylether (150 ml) at 0� C. The yellow ether solution of diazomethane (Note: explosive) is separated, is washed with water, and is added in portions to a solution of 5-fluoro-2-methylindene-3-acetic acid (90 mmol) in dichloromethane (200 ml). When the evolution of N2 ceases, the reaction is complete. After evaporation of the solvents, the residue is recrystallized from hexane to give methyl 5-fluoro-2-methyl-3-indenylacetate (yield 93%; m.p. 53� C.).
(B) 5-Fluoro-2-methyl-1H-3-indenyl-(2-hydroxy)ethane
To a solution of methyl 5-fluoro-2-methyl-3-indenyl-acetate (24 g) in dry THF (300 ml) lithiumaluminum hydride (6.9 g) is added. The mixture is stirred at room temperature for 1.5 hours. Excess LiAlH4 is destroyed with saturated aqueous NaHSO4 solution. The organic phase is concentrated in vacuo, and the crude product is purified via silica gel column chromatography elution with methylene chloride. The residue is recrystallized from hexane to give 5-fluoro-2-methyl-1H-3-indenyl-(2-hydroxy)ethane (yield 63%; m.p. 65�-66.5� C).
(C) (Z)-5-Fluoro-2-Methyl-1-(4-Methylsulfonylbenzylidene)-1H-3-Indenyl-(2-Hydroxy)Ethane
5-Fluoro-2-methyl-1H-3-indenyl-(2-hydroxy)ethane (15 g, 0.072 mol),
p-methylsulfonylbenzaldehyde (14.0 g, 0.091 mol) and sodium methoxide (13.0 g, 0.24 mol) are heated in methanol (200 ml) at 60� C. under nitrogen with stirring for 6 hours. The reaction mixture is poured onto ice-water (750 g), and is acidified with 2.5N hydrochloric acid. The collected solid is triturated with a little ether to produce (Z)-5-fluoro-2-methyl-1-(p-methylsulfonylbenzylidene)-1H-3-indenyl-(2-hydroxy)ethane. Recrystallization of the crude reaction product results in the separation of the mixture of geometrical isomers (Z/E) and gives the title compound (R1=5-fluoro, R2=CH3, R3=H, R4=CH2OH, n=1, R5=CH3SO2).
Formula: C20H19FO3S
Molecular Mass: 358.43 g/mol
Melting point: 118� C.
1H-NMR [ppm] (DMSO-d6): 2.14 (s,3,—CH3); 2.71 (t, 2,—CH2—); 3.29 (s,3,—SO2—CH3); 3.55 (m,3,—CH2—O); 4.70 (m,1,—OH); 6.68-7.14 (m,3,ar.);7.30 (s,1,═CH); 7.76-8.03 (AB,4,—Ph—SO2—);
IR [cm−1] (KBr): 3440 OH; 1300 S═O; 1170 C—F; 1140 S=O
A 16 year-old male patient with acne vulgaris was given a pharmaceutical composition containing 125 mg of a cGMP-specific PDE inhibitor, exisulind (the compound of Example 1) twice daily for 8 weeks. At the end of that time, the patient's acne was observed to decrease noticeably in intensity. Since the patient was tolerating that daily dose quite well, his dose of exisulind was increased to 150 mg twice daily, for an additional 8 weeks. By the end this second 8-week period, the patient's acne had disappeared completely, and the patient reported no adverse side effects, clinically significant or not. The patient continued on drug for six months without any significant manifestations of acne during that time.
The pharmaceutical formulation for the 150 mg-containing pharmaceutical composition taken by this patient contained exisulind (150 mg), lactose monohydrate (207 mg), croscarmellose sodium (15 mg), colloidal silicon dioxide (1 mg), magnesium stearate (6.3 mg), and sodium lauryl sulfate (0.7 mg) encapsulated in a #1 gelatin capsule. The exisulind was obtained from Zambon Group, S.p.A., of Milan, Italy. The pharmaceutical formulation for the 125 mg containing composition was formulated with less exisulind, and more excipients to fill the capsule.
Larger adult dosage forms simply contain more active ingredient, and less excipient. Pediatric or adult doses also may be formulated in tablet form of suitable dosages.
cGMP-specific phosphodiesterase activity can be determined using methods known in the art, such as a method using radioactive 3H cyclic GMP (cGMP)(cyclic 3′,5′-guanosine monophosphate) as the substrate for PDE5 enzyme (Thompson, W. J., Teraski, W. L., Epstein, P. M., Strada, S. J., Advances in Cyclic Nucleotide Research, 10:69-92, 1979, which is incorporated herein by reference). Using such techniques, the values of cGMP-specific inhibition set forth in Table I were determined for the compounds above:
It will be understood that various changes and modifications may be made in the details of procedure, formulation and use without departing from the spirit of the invention, especially as defined in the following claims.
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Sterling Silver Plated Purim Gift Basket Miniature
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This gift basket for Purim for decorative purposes is filled with all sorts of item you might need for the holiday and crafted from plated sterling silver. Read more
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Product Description
Revel in the joy of celebration with this fancy plated sterling silver gift basket for Purim filled with several objects. These objects, all part of the miniature, include a few Haman's ear, a wine bottle, a mask, and two groggers representing the ancient tradition and classic joy of the Purim holiday.
This gift basket of silver is an excellent suggestion for any friend or family for Purim.
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Material Silver Plated-Sterling silver 925
Dimensions 3.5 x 6.5 x 4cm
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4-8 Business Days.Learn More
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photography manipulation, graphic design
Spain - Last active: 2 months ago - Tests: 2 - Portfolio: 6
Over 6 years of experience in Photo-retouching and restoration and more than 9 years in creative art - drawing, illustration. I work with both - vector and pixel art - proficient in Photoshop CC, Lightroom 5,6, Inkscape and Corel Draw x5.
High-End Photography and Retouch
Serbia - Last active: 1 day ago - Tests: 5 - Portfolio: 19
Over 7 years of professional experience in photography and retouching images. I would like to state that I acquired my skills solely through real long-term real-world practice and not through a couple of online tutorials. For that reason I am very confident in my work and the versatility of my skills, and am able to provide a truly premium service. I offer a 100% satisfaction guarantee to all top -rated clients, including unlimited revisions - I won't rest until you are completely satisfied. As for the technical expertise, I am an exclusive photographer at iStockphoto and am used to rigorous technical standards, some of the highest in the photography world - and have honed my skills over time accordingly. Through my stock portfolio my work has also proven itself in the real world with thousands of publication and other uses (print, blogs, websites, and other commercial use). Due to the flexibility of my stock photographer job, I can rearrange my schedule to suit your needs and am available practically 24/7 when needed. I'm easy to work with, easy to communicate with and will always produce high quality work at a fair price. I will not tell you I can do something, if it can't be done. I won't mess around with your deadline. I want you to be able to do your job, and trust that I'll do mine as proposed. In return, I'm hoping to build long lasting professional relationships with clients that care enough about their business and understand the need for high quality work, and are willing to pay a fair price. Looking forward to hearing from you. Regards, Boris Lazic
Korean Translator with Photography Knowledge and Experience
United States - Last active: 1 month ago - Tests: 5 - Portfolio: 1
-Work History: *February, 1998~present: Freelance Interpreter & Translator, web researcher and media analyst specialized in legal, media, scientific and recruiting (marketing & sales) subject matter. *June, 2013~December, 2013: SAP Solutions Mgmt (Fairfax, VA, US), Work-at-Home freelance recruiter for SAP positions: Acquiring open position contracts from employers, analyzing the job details and posting the job descriptions online, screening and interviewing candidates, setting up a 2nd interview with actual employers. Mediating the contract conditions between the candidate and employer. Building up the employer and candidate pool. Introducing a relevant online course or intern position to candidates that need more training and experience. *March, 2008~October, 2009: Google Workforce Logic (CA, US), Work-at-Home per-project-contract position: Analyzing and Rating English/Korean Google ads/search results of Google Adwords, Adsense, search engine results and YouTube videos based on its guidelines. This work has been providing a lot of knowledge especially of what people are interested or think important with a keyword based research. *November, 2006~December, 2007 Appletree Recruiting (CO, US), Work-at-Home recruiter: Recruiting teachers in the US and Canada and matching them to public schools and learning centers in South Korea. Cold-calling prospect employers to build up client pool. Planning and executing sales & marketing strategies to attract well-qualified candidates. *May, 2006~October, 2006: Over-the-phone Korean interpreter for Language Line Services (CA, US), Work-at-Home contract position: Specialized in medical, insurance, financial and court interpretation. *September, 2004~November, 2005: SeoMyoungCoem, a water-processing cell developer (Gangwon-do, Korea): Director of translation & interpretation and web research including legal and scientific subject matter. This developer's main invention was a water-processing cell that oxidizes water up to a level where the processed water can wash dishes and garments without any detergent, in dishwashers and washing machines. My main duties were to perform phone and internet research/ translation to complete our patent application for the cell technology and its design, in US, Germany and South Korea; also to create various comparison charts and test result presentation materials in both, Korean and English with our team members. *May, 2002~September, 2004: Tomorrow Korea English School (Donghae, Korea) – Teacher Director: Interviewing, hiring, assigning personnel to their classes and managing teachers mostly from Canada. Evaluating curriculums. Consulting with parents. Setting up and executing marketing and publicity plan. Teaching English in English to Korean students ranging in age from 6 to adults, including TOEIC and TOEFL. Teaching Math and Science in English to Korean students ranging in age from 8 to 15. *March, 2000~July, 2001: MinByeongChul English School (Gangnung, Korea): Teacher Director: Interviewing, hiring, assigning personnel to their classes and managing teachers mostly from USA and Canada. Reviewing and revising curriculums. Teaching English in English to Korean students ranging in age from 8 to adults. *May, 1998~October, 1999: Si-Sa Language School (Samcheok, Korea): Teacher Director: Interviewing, hiring, assigning personnel to their classes and managing teachers mostly from Canada. Creating curriculums. Consulting with parents. Teaching English in English to Korean students ranging in age from 4 to adults, including TOEIC and TOEFL. Teaching Math and Science in English to Korean students ranging in age from 9 to 13. *February, 1997~January, 1998: Precomm, a medical device trade company (Seoul, Korea): Translation & interpretation and web research director. Its major medical devices were imported from US so I had to localize all the marketing materials into Korean. I also had to execute phone and internet research to get details about major competing devices to differentiate our devices to be appealed with more superiorities to our client doctors. Also whenever there was a meeting with staff from the manufacturer in US, my responsibility was to perform consecutive interpretations via phone or on-location.
Photography. Photoshop. English-Russian translation.
Russia - Last active: 12 hours ago - Tests: 5 - Portfolio: 15
Photography, especially portraits (30 years of experience). Photoshop (5 years of experience). http://victorsmirnov.crevado.com Took part at the exhibitions, printed in media. I work at my regular job for 24 hours every fourth day (unavailable), so if I do not answer you, it means that I am on my 24hour shift and I will answer you as soon as possible.
Creative Photo Editor (CORNERSTONE PHOTOGRAPHY)
Philippines - Last active: 11 days ago - Tests: 2 - Portfolio: 24
My skills: Photo Editing: * Changed Background * Retouching * Manipulation * Montage * Cropping * Color Enhancement Designs and Layouts: * Birthday/Wedding Invitation * Album Lay-out : Wedding & Birthday
Illustration / Graphic Design / Multimedia / Photography
Philippines - Last active: 13 days ago - Tests: 9 - Portfolio: 12
Engineering, photography editing, tech/photo writing, translations
Greece - Last active: 12 hours ago - Tests: 6
Highly motivated engineer with successful studies in the UK and cross-functional professional experience in the fields of manufacturing project engineering, technical sales and financial services. Proven history of goal attainment. Use of strong analytical skills, excellent team cooperation and technical-business wisdom for positive contribution to the organization. Ability to conduct business in perfect English and Greek, good French and fair German. Strong computer skills in multiple platforms.
Creative Visual Professional - Rendering, Design, Photography
United States - Last active: 4 months ago - Tests: 7 - Portfolio: 9
Hey! My name is Jon and I am an artist, designer, and photographer based in Northwest Arkansas. My areas of expertise range from illustration, concept rendering, product development, brand identity, general and artistic graphic design, and artistic, product, and event photography. My purpose is to provide exceptional services in a timely manner. I believe what separates good work from great work is in the details. Providing excellent end results not only means understanding the design brief, but getting to know the client, the culture, and the intended audience. I pride myself with being flexible and having the ability to tackle unexpected needs easily. I am easy to get in touch with, and even when I am away from the office I travel with the necessary equipment so I am always ready to take care of your needs. I can provide the visual elements that will surpass your expectations. My success is in your success. I have placed a few items from my portfolio here. You can also see more portfolio items at www.jonbuckner.com
High-end retouching, color correction, photography
Ukraine - Last active: 1 day ago - Tests: 5 - Portfolio: 7
Professional photographer since 2009 year Professional retoucher since 2009 year My portfolio: https://500px.com/Rezni_k My skills: Adobe Photoshop Adobe Photoshop Lightroom Kolor Autopano Giga Kolor Panotour Pro I offer: Retouching fashion and wedding photography High-end skin retouching Isolating images on a white background Color correction I work fast and qualitatively
print design, web design, retouching, photography, page-proofs
Ukraine - Last active: 12 hours ago - Tests: 4 - Portfolio: 37
Hi. My name is Roman and I'm from Ukraine. Since 2003 till now I have been working as a print designer in my country. For all these years I have sharpened my skills and experience and now I'm working as a freelance designer here on Upwork. Preferring minimalistic and clear style in work, I'm always attentive to details, stick to the set deadlines, and try to achieve the best results with projects to satisfy clients' needs. I have a solid knowledge of printing processes, so you won't have any issues with files you get from me. Please feel free to contact me for additional questions.


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Stage Lights Facebook Layouts
User Created Layouts
Here are some Facebook "stage lights" layouts our members created.
theme: industrial
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2011 MotoGP
Although the reigning MotoGP Champion Jorge Lorenzo suffered a huge crash in Free Practice 3, the Spaniard dominated qualifying, taking the pole position.
2011 MotoGP
When the 18-rider MotoGP grid finished the first day of practice at Laguna Seca, the shortest circuit on the 2011 schedule, three riders stood out – Jorge Lorenzo, Dani Pedrosa and Casey Stoner.
2011 MotoGP Video
The free practice sessions opened up with many accidents at Sachsenring, Germany, for Round 9 of the 2011 MotoGP Championship.
Some big names hit the pavement, including Ducati Team's Valentino Rossi and two of the Repsol Honda boys, Casey Stoner, Dani Pedrosa.
2011 MotoGP Wallpaper
At last weekend's Germany MotoGP in Sachsenring, the Repsol Honda trio finished within the top four – Dani Pedrosa took the win, Casey Stoner third and Andrea Dovizioso fourth.
2011 MotoGP
During the opening practice session for the Germany MotoGP at Sachsenring, some MotoGP riders such as Valentino Rossi, Casey Stoner, Dani Pedrosa and Toni Elias hit the pavement. In the following report, Bridgestone discusses the incidents.
2011 MotoGP
Although he finished in the top four at all three free practice sessions for this weekend's Sachsenring MotoGP in Germany, Casey Stoner catch the riders on top.
2011 MotoGP
Following is the pre-race press conference from Sachsenring MotoGP, featuring Valentino Rossi, Casey Stoner, Jorge Lorenzo, Dani Pedrosa and Loris Capirossi
MotoGP Stoner Cornering Video
Casey Stoner got style. In his very first year on the Repsol Honda RC212V, the Australian has been in dominate form, including winning four of eight rounds so far in the 2011 MotoGP Championship.
2012 MotoGP
With the 1000cc MotoGP era arriving in 2012, all the riders will have to adapt their riding styles. One rider who has been very talkative about the 1000cc era is Repsol Honda's Casey Stoner.
Following is an interview courtesy of Honda Racing Corporation:
2011 MotoGP
After taking third in Mugello on Sunday, Casey Stoner returned with vengance on Monday for an official MotoGP test.
2011 MotoGP
For the fifth time in the 2011 MotoGP Championship, Casey Stoner placed his Repsol Honda RC212V on the pole.
Stoner not only beat out the remaining 15-rider grid (short Loris Capirossi), he also set a new lap record at Mugello with his 1:48.034.
2011 MotoGP
Following are comments from Casey Stoner, Valentino Rossi, Ben Spies, Dani Pedrosa and Marco Simoncelli as they prepare for this weekend's Mugello MotoGP
2011 MotoGP
Heading into Round 7 of the 2011 MotoGP Championship in Assen, the Repsol Honda team has two major issues, one bad, one good.
For the good, Casey Stoner took the championship lead after another dominiating performance at Silverstone two weeks ago, the Australian winning four of six rounds so far in is debut year on the Repsol Honda RC212V.
2011 MotoGP
Hirohide Hamashima of the Bridgestone development division provided an analysis of tire compounds used during the difficult and wet MotoGP weekend at Silverstone.
The AirAsia British Grand Prix thoroughly tested the tire compounds Bridgestone supplied for the sixth round of the 2011 Championship.
2011 MotoGP
On a slick Silverstone Circuit, Casey Stoner took his 34th World Championship victory, including his fourth in the 2011 MotoGP Championship.
Due to his win at Round 6 of 18, Stoner now has the MotoGP Championship lead, 18 ahead of Yamaha Factory Racing's Jorge Lorenzo, who crashed out of Sunday's Silverstone race.


text:
Gay Republican assaulted for political activism
This morning, Daily Caller was kind enough to publish an article I wrote about a vicious assault done to Kyle Wood, a gay volunteer for a Republican campaign in Wisconsin. Kyle ended up in the hospital:
Kyle Wood, a full-time volunteer working for GOP House candidate Chad Lee, was hospitalized for injuries suffered during what he said was an assault at his home.
Wood told The Daily Caller that vandalism preceding the assault, along with his attacker's statements during the incident, suggested his sexual orientation and his politics each played a role.
"I was getting ready for work and there was a knock at the door," Wood emailed The Daily Caller late Wednesday. "I opened it, and a guy wrapped a ligature around my neck, slammed my head into the doorway, and smashed my face into a mirror, telling me 'You should have kept your [f*******] mouth shut.'"
"He then kidney-punched me, while at the same time saying I was 'warned,' and continued to beat me," he added.
Wood said his attacker's reference to a warning likely pointed to graffiti he found painted on his car last week. The vandalism included the phrases "house trained republican faggot," "traitor," and "ur like a jew 4 hitler."
After he discovered the graffiti, Wood wrote an open letter on Facebook to the unknown vandal. "If you understand either freedom or me at all," he wrote, "you would that this will only make me work harder. … You can think whatever you like about me, but I will not be bullied into voting for a gay man simply because I am gay."
He's also standing up against his unknown assailant:
"I will not be bullied, intimidated or threatened into abandoning my moral values," Wood told TheDC late Wednesday.
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Dustin Siggins
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