text:
For One Day Only: $1=$4, Thanks to Matching from BIG Donors
Rabbi Horowitz's recently released parenting book, Living and Parenting (ArtScroll), can be obtained by visiting www.rabbihorowitz.com, e-mailing firstname.lastname@example.com, calling 845-352-7100 x 133, or visiting your local Judaica store.
* * * * * * * * * *
As Bnei Yisroel passed through the land of Ya'azer and Gilad in the "Ever HaYarden" (land East of the Jordan River) they noticed that the land was very fertile and quite suitable for grazing animals.
The two shevatim (tribes) of Reuven and Gad, who had large flocks of cattle, spoke to Moshe and expressed their desire to settle in Ever HaYarden – even though it was not part of Eretz Yisroel proper.
Having led his people through the desert for 40 years with the hope of reaching the holy soil of Eretz Yisroel, Moshe was understandably disappointed that two shevatim relinquished their portion in the Promised Land in exchange for a parcel in Ever HaYarden.
Harsh Words
Moshe expressed himself rather sharply to the leaders of Reuven and Gad. He asked them why they would weaken the spirit of their brothers by not accompanying them to Eretz Yisroel and going to battle alongside the members of the other Tribes.
Moshe reminded them of the terrible damage done by the demoralizing report of the meraglim (spies). He wondered why these two shevatim would risk incurring the wrath of Hashem by demonstrating their willingness to forgo the privileged of entering Eretz Yisroel – a zechus denied to Moshe himself.
An Additional Rebuke
Moshe also gave them tochachah for their lack of proper priorities. When speaking to Moshe, they stated that they had every intention of supporting the war efforts of the remainder of Klal Yisroel. "We will build pens for our flocks of cattle and cities for our children (Bamidbar 32:16).
Moshe admonished them for placing their possessions before their children. He implied that their priorities were misplaced, perhaps as a result of their intense focus on the needs of their flocks.
The people of Reuven and Gad accepted Moshe's rebuke, and recalibrated their priorities. In fact, the next time they discussed their arrangements with Moshe (Bamidbar 32:26), they listed their children and wives before their cattle.
An Interesting Observation
The Ohr HaChaim notes that the leaders of the shevatim expressed their acceptance of Moshe's rebuke using two different terms. They said that they would do " as Moshe instructed us" (Bamidbar 32:25). Two pesukim later, they said that they would join Bnei Yisroel in battle, " as my master has spoken."
The Ohr HaChaim offers a lengthy explanation as to the reason for the two distinct terms that the people of Reuven and Gad used (see Ohr HaChaim, Bamidbar 32:25 for the full text).
A Deeper Level
I would like to suggest an additional thought as to the usage of these two terms.
Advice and guidance can be adhered to on two very different levels. The first is to follow what we were instructed to the letter of the law. A much deeper commitment is to truly get the "big picture" of what we are being told. When that happens, we don't merely do what we are told. We internalize the lessons and change our view of things as a result of the wisdom we attained by listening to the constructive criticism that we were given.
The Bnei Reuven and Gad realized that their moral compass became skewed as a result of their newly acquired wealth. They were struck by the fact that they inadvertently mentioned their possessions before their children. Once they internalized the criticism of Moshe, they informed him that they were willing to improve and change the course of their lives.
"We will do what you instructed us," they told Moshe. Much more importantly, they accepted the full meaning and import of their rebbi's words – and the course of their lives.
Best wishes for a Gutten Shabbos.
Rabbi Yakov Horowitz is the founder and dean of Yeshiva Darchei Noam of Monsey, and the founder and director of Project Y.E.S.
To purchase Rabbi Horowitz's Dvar Torah Sefer, Growing With the Parsha or his popular parenting tapes and CD's – including his 4-CD set "What Matters Most" – please visit www.rabbihorowitz.com, email firstname.lastname@example.com, or call 845-352-7100 x 133.
About the Author: Rabbi Yakov Horowitz is founder and dean of Yeshiva Darchei Noam and founder and director of Agudath Israel's Project Y.E.S.
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Orlando was once a place where people came only to visit and vacation. Now it is home to a burgeoning Torah community, a place Jewish families can be proud to call home.
The smuggler's life has been changed forever. He is faced with a major criminal charge. He will probably be sent to prison.
"Thanks to a local philanthropist who shares our core mission, we now are able to connect more Jewish teens to Israel than ever before," said Todd Cohn, executive director of Southern NCSY.
In September 2013 he was appointed head rabbi of the IDF Central Command and is currently in charge of special projects for the IDF chief rabbinate.
Last month we outlined how a few years after Judah Touro's death a public movement was inaugurated by the citizens of New Orleans to erect a monument to his memory, and that opposition to this tribute came from a number of rabbis throughout the country who claimed that Judaism forbade the erection of any graven […]
Marceau suggested a dark reason for his wordless art: "The people who came back from the [concentration] camps were never able to talk about it…. My name is Mangel. I am Jewish. Perhaps that, unconsciously, contributed towards my choice of silence."
Anna Henriques, who hopes to one day head back to Jamaica, says, "Rabbi Raskin must be willing to respect what exists in Jamaica. The way to the future is to gently bring in the traditions of the past and at the same time embrace the idiosyncrasies of the Jamaican people."
The Silver Platter has it all: gorgeous photography, oodles of useful tips and, more importantly, incredible recipes that you will find yourself making again and again.
It may be that seeking to connect with the past is rooted in the impermanence and impersonality of modern life.
It is very hard to build a healthy marriage when you do not have good role models.
My best book is one that hasn't been published yet.
We tend to justify and idealize this division with pride attributing these tendencies as demonstrating a higher level of kedushah.
Those of us familiar with the do's and don'ts of accepted practice in the mental health profession saw similar blaring warning lights in our minds, as should have occurred when the facts were made public regarding the accusations against Nehemia Weberman. This case may very well be our community's most important abuse trial during our lifetimes. It is imperative that we have a huge turnout in support of the victim, a courageous young lady who, may she be gezunt andge'bentched, is determined to see this through to the end so others won't suffer like she did.
In part the altered lives victims of abuse and molestation live are a result of the abuse itself. But it is in part also because of the unfortunate negative reaction to the victims by their own community.
These lines are written in loving memory of our dear father, Reb Shlomo Zev ben Reb Baruch Yehudah Nutovic, a"h, whose first yahrzeit is 7 Menachem Av. May the positive lessons learned from this essay be a zechus for his neshamah.
All responsible leaders in our community have roundly condemned the recent violence in Beit Shemesh and Meah Shearim.
A surefire way to gauge the generation in which a person was raised is to have him or her fill in the following sentence: Where were you when ?"
Baby Boomers would ask, "When President Kennedy was shot?" Thirtysomethings would respond, "When the space shuttle exploded?" Today's teenagers would reply, "On 9/11?"
One week ago on my website I announced my intention to attend the next court appearance of a man who was arrested last year and is now standing trial on 10 felony charges of child abuse.
Dear Rabbi Horowitz:
We were taken aback when our 18-year-old son just called us from Eretz Yisrael (we live in Europe) and told us that he was coming home and wants to immediately go to work. He said that he is wasting his time in yeshiva, and just can't take it anymore. He said that he will "run away from home" if we don't allow him to go to work.
Digital images of the profoundly disturbing computer-smashing ceremony conducted by Rabbi Aaron Feinhandler have been viewed by countless thousands of Jews worldwide over the past few weeks.
Printed from: http://www.jewishpress.com/sections/family/parenting-our-children/getting-the-big-picture-2/2008/07/23/
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Synthesis and Self-Assembly of Monodispersed Metal-Organic Framework Microcrystals
Article first published online: 12 OCT 2012
DOI: 10.1002/asia.201200754
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Chemistry – An Asian Journal
Volume 8, Issue 1, pages 69–72, January 2013
Additional Information
How to Cite
Lu, G., Cui, C., Zhang, W., Liu, Y. and Huo, F. (2013), Synthesis and Self-Assembly of Monodispersed Metal-Organic Framework Microcrystals. Chem. Asian J., 8: 69–72. doi: 10.1002/asia.201200754
Publication History
- Issue published online: 20 DEC 2012
- Article first published online: 12 OCT 2012
- Manuscript Received: 17 AUG 2012
Funded by
- Nanyang Technological University
- AcRF Tier 1. Grant Number: RG 42/10
- Ministry of Education, Singapore
- Singapore National Research Foundation
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subset: commoncrawl


text: Thoroughly enjoyed a 3 day off-season stay here where we lounged in the hot tub overlooking the redwoods & strolled with our dog along the riverfront. My husband has never been so relaxed. The cabin is fully equipped, very cozy, & very roomy -- easy to spread out if needed. Hosts are immediately available for any questions. Perfect location for... more


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text:
Matt Brickman
Guest Pass: Granny's Donuts
At Granny Donuts, in West St. Paul, it's a race to keep the display case stocked. "Sometimes if we don't get here early enough in the morning, they're all gone and then we don't get the favorite donuts," frequent customer Jane Williamson said.
Guest Pass: Shoreview Community Center
In the depths of a Minnesota winter, it's hard to remember what being warm feels like. But inside the walls of the Shoreview Community Center, you heat up in a hurry.
After Deep Freeze, Minnesotans Will Get A Taste Of Spring
After a week of arctic chills, warm air will wash over Minnesota and snow will be melting by the weekend.
Blizzard Conditions Close Southern Minnesota Highways
While temperatures climbed above zero in Minnesota on Thursday, schools across the state were still canceling classes as strong winds threaten blowing snow and dangerous driving conditions.
Mpls. Schools Cancel Classes Ahead Of Wednesday's Cold
Ahead of Wednesday's forecasted cold, schools across Minnesota are telling students and parents that classes will be delayed or canceled. Minneapolis Public Schools announced Tuesday that classes and activities are canceled Wednesday.
Wind Chill Advisory In Effect Until Noon
A wind chill advisory is in effect Tuesday morning for Minnesota and western Wisconsin as a blast of arctic air descended on the Upper Midwest.
Guest Pass: Woodbury's Bielenberg Sports Center
It's news to no one that in Minnesota, it gets cold in the winter. So a lot of communities have built inflatable sports bubbles so students athletes can get in off-season practice. But, Woodbury just ditched it's dome for a gorgeous new sports complex that's not just for kids.
Guest Pass: Alpine Farms In Medina
In this week's Guest Pass, Matt Brickman takes us to Alpine Farms in Medina, where they teach horses and riders to run, jump and an Olympic sport called dressage.
This Could Be The Coldest Thanksgiving Since 1930
Minnesotans woke up to subzero temperatures on Thanksgiving Day, and if the mercury doesn't make it to the double digits, the day could be one for the record books.
Guest Pass: Geocaching At Oakdale Nature Preserve
After two weeks in the deep freeze, Matt Brickman was getting a little stir crazy. So for this week's Guest Pass, he headed outside to have fun in the snow while geocaching at Oakdale Nature Preserve.
Guest Pass: Skateville In Burnsville
This week's Guest Pass takes Matt Brickman to the south metro to check out Skateville in Burnsville. The roller rink has been in in Burnsville since 1972.
Minn. Sees More Than A Foot Of Snow In Season's 1st Storm
The flakes of the season's first major snow storm began falling on Minnesota Monday morning, and by the time the clouds clear out Tuesday, around a foot of snow could blanket a swath of the state.
2014's Minnesota Weather Extremes: A Look Back
With 2014 starting to wind down and a whole new set of Top 10 Weather Days just around the corner, it's a perfect time to take a trip down memory lane. The past year was full of weather extremes. On the cusp of the change from fall to winter, Kylie Bearse sat down with the rest of the WCCO weather team to look back at all Minnesota has endured this past year.
Guest Pass: Orchids Limited In Plymouth
Matt Brickman asked help from viewers finding something to show off in Plymouth. There were lots of good ideas, but a family business with an international reach caught our attention. This week, your Guest Pass is to Orchids Limited.
Guest Pass: Minnesota Landscape Arboretum
We're starting to reach the tail end of fall color season here in Minnesota, but there's a spot in the metro where nature's beauty is one display, year round. The Japanese Garden is the Arboretum's most visited space and, even with leaves blanketing the ground, one the most beautiful.
Good Questions: Partly Sunny, License Plates & Top 10 Weather Days
Joann from Arden Hills asked: What's the difference between partly sunny and partly cloudy? "This is kind of a gray area," said WCCO-TV Meteorologist Matt Brickman. "I think meteorologists give themselves a little leeway. I always think in terms of percentages."
Guest Pass: Band Box Diner In Minneapolis
The Band Box is a place that any "knuckle puck" fan would recognize from the beginning of "D2: The Mighty Ducks."
Guest Pass: Northeast Minneapolis' Brickmania
In this week's Guest Pass, Matt Brickman takes us inside a LEGO lover's dream: Brickmania in northeast Minneapolis.
Guest Pass: St. Paul's Union Depot
Unless you're coming into the Twin Cities by rail, a train station probably doesn't make your must-see list.
Guest Pass: Guthrie Theater's Endless Bridge
Completed in June of 2006, the gravity defying structure at the Guthrie Theater is architect Jean Nouvel's signature feature.
DeRusha Eats: Rise Bagels
If you ask an east coast native about Twin Cities bagels, you're probably going to get a violent reaction. But instead of complaining, two sisters decided to start boiling and baking their own bagels. And that makes a difference, as Jason DeRusha found out.
Guest Pass: Lebanon Hills Park In Eagan
From the parking lot, you can tell that this is more than a run-of-the mill municipal park.
Best Of Minnesota: Looking Back At The Best Of Matt Brickman
Matt Brickman has taken WCCO viewers to see the Best of Minnesota: A lot of great food, interesting places, but most of all, interesting people.
WCCO Viewers' Choice For The Fair's Best Cool Treat
You might see malts elsewhere on the fairgrounds, but if you want the best, you've gotta go to the source–the Dairy Building.
WCCO Viewers' Choice For Best Animal Exhibit At The State Fair
There are so many reasons to love the Minnesota State Fair. For some it's the food, for others it's the rides. But for many, it's getting to see all the farm animals up close.


text:
Dr. Antonio E. Blanco, MD
Family Medicine
- 30334 Old Dixie Hwy
Homestead, FL 33033
- 3 Locations
- (786) 243-0149
Dr. Antonio E. Blanco graduated from the Georgetown University School of Medicine in 1988. He works in Homestead, FL and 2 other locations and specializes in Family Medicine and Internal Medicine. Dr. Blanco is affiliated with Baptist Hospital Of Miami and Homestead Hospital.
Family Medicine, Internal Medicine
Medical School: Georgetown University School of Medicine; Graduated 1988
*This physician has multiple office locations. See Office Information for details.
1350 SW 4th St
Homestead, FL 33030
2048 NE 8th St
Homestead, FL 33033
15335 SW 288th St
Homestead, FL 33033
1645 NE 8th St
Homestead, FL 33033
27104 S Dixie Hwy
Naranja, FL 33032


text:
dselec.wordpress.com writes:
This is a countdown counter based on ATtiny2313, primary developed for my PCB exposure box, but it can be used for other purposes too.
The counting range is between 1 and 90 minutes and it can be adjusted with up or down buttons (high and low in the pictures).
After the desired time is set, the countdown starts by pressing the start/stop button (on/off in the pictures). By pressing the same button we can interrupt the counting at any time we want.
After the count expires we hear a beeping sound and the load is disconnected. By pressing start/stop button we reset the counter and we are ready for another lap. All actions included the time remaining are shown in the LCD display.
Pcb countdown timer – [Link]
Arduino CrossFit Timer – [via]
I was looking for, what I thought, was a simple clock/timer design. Something with a remote and a big display that could be read from across the gym and that I could program with up/down counting but also intervals specific to CrossFit like Fight Gone Bad or tabatas. I wanted to incorporate a bell to give it a gym feel and something that could be heard over loud music. This journey took me through many designs, chips, a custom board, wood working and a whole lot of learning!
Arduino CrossFit Timer – [Link]
Charalampos Andrianakis writes:
Two years ago i modified a scanner replacing its mechanism and all the internal electronics with UV lamps converting it to an UV exposure box for PCB prototyping. By the need of making my life easier and not waiting for the pcb to be exposured i designed an AVR timer to automatic switch off the lamps after 1 minute of exposure which was much enough for the PCBs. Here is the circuit
This was one of my first completed projects from design to production. As you can see the scheme isn't that good and there have been by passed some capacitors at the power supply. But the circuit works with no problem.
AVR Switch Timer – [Link]
kalshagar.wikispaces.com writes:
Goal is to replace this Ikea super cheap timer that works … well, as good as something manual that you paied less than 200 JPY (less than 2 euro). Not precise, sometimes doesn't ring, or ring just the blink of an eye, so easy to miss…
The new timer will:
- Have a graphical LCD (bought one one year ago, never used it, needed a pretext, so…)
- Work on battery (1x 9v battery)
- Play music when it's time
- Use a speaker and amp
- Possibly use a YMZ294 ?
- In fact something else but much better…
- Have an on/off system with a push-button, not a open/close switch In fact a tilt switch
- No arduino, but a simple atmega 328 (more than sufficient)
- Keep me busy a few days while allowing me to use some parts I bought long time ago and create a un-reasonable and out of price kitchen timer
Arduino KitchenTimer – [Link]
embedded-lab.com writes:
Last week I was browsing my old backup hard drive and I found a source code for a very simple PIC based digital timer that I made a couple of years ago. The actual hardware of the project isn't with me anymore. I might have lost it when I moved from my old apartment into my new home. However, I thought this might be a good practice project for beginners and so I am sharing it here. I am not going to build it from scratch again; I will rather demonstrate it using my DIY PIC16F628A breadboard module and I/O board. The complete circuit diagram along with the firmware developed using mikroC Pro for PIC compiler is provided in the article.
00 to 99 minute timer using PIC16F628A microcontroller – [Link]
anonymouse197 writes:
This instructable will guide you through creating your own Arduino based Kitchen Timer. This is a quite simple project, requiring little or no programming or electronics knowledge, just the willingness to learn and fiddle – an ability most useful for modern man.
This kitchen timer is simple enough, press and hold a button and it will count up it multiples of five minutes, until you release the button. Upon doing so the timer will flash, and begin counting down. This timer includes an alarm and a display, with a piercing piezo buzzer to get your attention.
The arduino, laptop, protoshield, and USB Cable excluded; I took every electrical component from an old or broken device. Try to recycle things, its easy to get hold of broken electronics for free so make the most of it! See any jumpers on this design? No, paper clips are much better – cheap as chips and more sturdy too!
Arduino Kitchen Timer – [Link]
- No power supply needed: The circuit "steals" in the operating current (only 10µA at 5V and 2.5µA at 3.3V) from the signal lines of the camera
- Interval adjustable from 0.4 seconds to about 18 minutes
- No controls, setting of the intervall via "teach-in" from the camera
- Ultra-portable: the circuitry fits into the housing of a 2.5mm stereo plug
- Component cost: 87 ct (July 2010)
Intervall Timer for Nikon and Canon DSLR – [Link]
In Los Angeles, we have the "Time-of-Use Program" option from the power company. From their FAQ:
The prices are based on the time of day when the electricity is actually used, unlike the standard rate when the price for electricity is always the same.
A higher price is charged during "high peak" hours, which are between 1:00 p.m. and 5:00 p.m., Monday through Friday. The price for electricity during these hours is about twice the cost of the standard rate price.
Surrounding these "high peak" hours, are the "low peak" hours. "Low peak" hours are from 10:00 a.m. to 1:00 p.m. and again from 5:00 p.m. to 8:00 p.m., Monday through Friday. The price for electricity during these hours is slightly higher than the price charged on the standard rate.
During all of the remaining hours, Monday through Friday, and all weekend long, the price for the electricity you use is about one-half of the price for electricity on the standard rate. These hours are called "base" hours.
I was lucky in that my house came with a mechanical timer (as part of some Frankenstein solar system). It was easy to set it to turn off the hot water heater from 1 to 5pm. Don't forget about daylight saving time, oh how I hate daylight saving time.
This worked fine except for the most weekends we would forget to reach into the box and turn on the hot water before during laundry or grabbing that all important weekend noon shower. Even the ridiculous note didn't help.
Smarter Water Heater Timer – [Link]
dangerousprototypes.com writes: [via]
What's in a name? David L. Jones of EEVBlog thinks he's found an Easter egg in the performance characteristics of the 555 timer chip which reveals the basis of the "555″ in its name. Build his circuit (schematic at video 13:25), fire up the scope and see if you agree!
555 timer Easter egg? – [Link]
Victor from Roteno Labs has built this Earthquake Sounder based on the 555 Timer called the Terremoto as a submission to the 555 Timer Contest. [via]
The USGS maintains a server online that consolidates all the seismic data received from sensors all around the world. Terremoto uses an LPC Expresso board and an XPORT AR ethernet module to query the USGS server for a list of earthquake activity. When a new earthquake is received by Terremoto, tones are generated that correlate with the magnitude of the earthquake.
Terremoto – Earthquake Sounder based on the 555 Timer – [Link]


text:
Ruby on Rails Developer
United States - Last active: 1 day ago - Tests: 2 - Portfolio: 8
I am a talented and experienced full-stack web application developer. I work almost exclusively in Ruby on Rails. I love developing applications "the Rails way". I appreciate the brilliance of the Rails architecture and enjoy using it to build world-class applications. I've created a number of complex systems using Rails including e-commerce sites, inventory management systems, scheduling systems, forum applications, internal organizational systems, and order fulfillment systems. My rails knowledge is also augmented with intimate knowledge of HTML5, CSS3, Sass, SQL, and jQuery.
Ruby On Rails Developer
Poland - Last active: 17 days ago - Tests: 8 - Portfolio: 5
Ruby on Rails Developer
Russia - Last active: 1 month ago - Tests: 4 - Portfolio: 5
After the 8 years of professional web development, I have a good experience in Software Engineering. I love Agile and Lean methodologies, TDD, XP and so on. I was involved in almost all parts of software development – coding, server and database configuration, application (software) design, consultations and hiring. And I like contributing to Open Source projects.
- Ruby on Rails
- Ruby
- JavaScript
- jQuery
- Linux System Administration
- MySQL Administration
- Smarty
Associated with: Kodo Labs Agency
Ruby on Rails Developer
Ukraine - Last active: 22 hours ago - Tests: 3 - Portfolio: 2
I'm a full-stack Ruby on Rails developer with Agile approach and pair programming enthusiast. What I do best (my favorite tasks): * Backend developer with Ruby on Rails and PostgreSQL * Front end development with HTML, CSS (HAML/SLIM and SCSS/SASS), Javascript (Jquery) * Zero downtime deployment with: Ubuntu / Puppet / Capistrano stack. NewRelic for monitoring. * Payment gateways: Stripe. * TDD and BDD: Rspec and Capybara are my favorite frameworks
Associated with: MXPV
Ruby on Rails Developer
Russia - Last active: 3 months ago - Tests: 4
I'm a Ruby/RoR developer with extensive experience in both back- and front-end development, contributing to open-source software. * Ruby/Ruby on Rails, Scala * HAML, SASS, jQuery, Twitter Bootstrap/ZURB Foundation * RDBMS: PostgreSQL/MySQL * NoSQL, in-memory, key-value stores: MongoDB, DynamoDB, Redis * TDD/BDD: RSpec, MiniTest, Capybara, Cucumber, Selenium, ScalaCheck, ScalaTest * Heroku, EC2, DigitalOcean, OpenShift * git * various gems and libraries
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On Tue, 5 Feb 2013, Jeff Ortel wrote:
Does anyone know if this width can be changed in github? Making the window wider does not seem to help. If not, I propose a coding guideline in pulp that requires lines to be <= 110 characters for this reason.
+1 -- Randy Barlow


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RECENT GALLERIES- PHOTOS: Rollins & Ambrose Debut New Ring Gear!
- PHOTOS: Seth Rollins Debuts New Ring Gear!
- EXCLUSIVE PHOTOS: RAW Script For June 2, 2014!
- PHOTO: Luke Gallows' New Real-Life Wife!
- PHOTOS: Bray Wyatt's Real-Life Sister!
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The Huffington Post's online show spoke with WWE Hall of Famer Shawn Michaels who hinted at his involvement in the Triple H vs. Brock Lesnar Match at WrestleMania this weekend. Below are some highlights:
Michaels on being in Triple H's corner: "Obviously, I'm going to be there in his (Hunter's) corner. The whole time. Yeah, you can't have WrestleMania without Mr. WrestleMania if I'm just standing there. I'm going to do something. Are you kidding me? I'm going to stick my nose in there and do something. I'm going to cause some kind of trouble, I just hope it's not for Hunter (whose career is on the line in the storyline)."
On the challenge of WWE delivering original television every week: "They have a lot more television shows and the challenge for them is – it's tough to continue be creative when you're producing four television shows a week. You have a live Monday Night Raw every Monday night 52 weeks a year, so it's an Iron Man's job."
Michaels speaks on the physicality of the schedule: "It's an unbelievably physically-demanding job. You're doing it 250 days a year in different cities every night. Other jobs are tough as well, but football, basketball, and baseball are seasonal. In MMA, they'll take three or four fights a year. It has its tough job requirements as well, but WWE is no cake-walk, but it is a glorious existence."
His thoughts on CM Punk being compared to himself: "I think he's going to be his own guy and that's what I like about Punk. He's got a great attitude, so he's certainly going to be one of the guys who is the future of WWE."


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Telephone: (585) 275-7986; FAX: (585) 276-0054
Original Articles
Survival outcomes in liver transplantation for hepatocellular carcinoma, comparing impact of hepatitis C versus other etiology of cirrhosis†
Article first published online: 30 MAY 2007
DOI: 10.1002/lt.21054
Copyright © 2007 American Association for the Study of Liver Diseases
Liver Transplantation
Volume 13, Issue 6, pages 807–813, June 2007
Additional Information
How to Cite
Bozorgzadeh, A., Orloff, M., Abt, P., Tsoulfas, G., Younan, D., Kashyap, R., Jain, A., Mantry, P., Maliakkal, B., Khorana, A. and Schwartz, S. (2007), Survival outcomes in liver transplantation for hepatocellular carcinoma, comparing impact of hepatitis C versus other etiology of cirrhosis. Liver Transpl, 13: 807–813. doi: 10.1002/lt.21054
- †
See Editorial Page 783
Publication History
- Issue published online: 30 MAY 2007
- Article first published online: 30 MAY 2007
- Manuscript Accepted: 27 OCT 2006
- Manuscript Received: 28 OCT 2005
- Abstract
- Article
- References
- Cited By
The incidence of hepatocellular carcinoma (HCC) is on the rise worldwide as the most common primary hepatic malignancy. In the US approximately one half of all HCC is related to Hepatitis C virus (HCV) infection. The relationship between the primary disease and HCC recurrence after liver transplantation is unknown. We hypothesized that the primary hepatic disease underlying the development of cirrhosis and HCC would be associated with the risk of recurrent HCC after transplantation. A retrospective review was conducted of all primary liver transplants performed at the University of Rochester Medical Center from May 1995 through June 2004. The pathology reports from the native livers of 727 recipients were examined for the presence of HCC. There were 71 liver transplant recipients with histopathological evidence of HCC. These patients were divided in two groups on the basis of HCV status. Group 1 consisted of 37 patients that were both HCV and HCC positive, and Group 2 consisted of 34 patients that were HCC positive but HCV negative. Patient characteristics were analyzed, as well as number of tumors, tumor size, presence of vascular invasion, lobe involvement, recipient demographics, donor factors, pretransplantation HCC therapy, rejection episodes, and documented HCC recurrence and treatment. There were no statistically significant differences between the 2 groups, with the exception of recipient age and the presence of hepatitis B coinfection. The tumor characteristics of both groups were similar in numbers of tumors, Milan criteria status, vascular invasion, incidental HCC differentiation, and largest tumor size. The HCV positive population had a far lower patient survival rate with patient survival in Group 1 at 1, 3, and 5 years being 81.1%, 57.4%, and 49.3% respectively, compared with 94.1%, 82.8%, and 76.4% in Group 2 (p = 0.049). Tumor-free survival in Group 1 at 1, 3, and 5 years was 70.3%, 43%, and 36.8% respectively, vs. 88.1%, 73%, and 60.8% in Group 2. In a subgroup analysis, tumor-free survival was further examined by stratifying the patients on the basis of Milan criteria. Group 1 patients outside of Milan criteria had a statistically lower tumor-free survival. By contrast, there was no statistical difference in tumor-free survival in Group 2 patients stratified according to Milan criteria. Cox regression analysis identified HCV and vascular invasion as significant independent predictors of tumor-free survival. Our results suggest that Milan selection criteria may be too limiting and lose their predictive power when applied to patients without HCV infection. Liver Transpl 13:807–813, 2007. © 2007 AASLD.
Worldwide, hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy, with an annual incidence of over half a million cases.1 The single most important risk factor for the development of HCC is cirrhosis; however, the risk of developing HCC varies with the etiology of cirrhosis.2, 3 If cirrhosis develops as a consequence of genetic hemochromatosis and iron overload, the risk for developing HCC is high (7–9% per year).4 Primary biliary cirrhosis, alcoholic cirrhosis, α1-antitrypsin deficiency, and Wilson disease are all implicated as risk factors for the development of HCC. Cirrhosis as a result of chronic viral hepatitis, however, accounts for most primary liver cancer worldwide.5, 6 Numerous epidemiological studies have established a clear association between chronic viral infection and development of HCC.7–10
Liver transplantation is conceptually an attractive therapy for HCC in a cirrhotic liver because it incorporates the radical resection of a total hepatectomy combined with liver replacement.11, 12 Although initial results were disappointing,13–17 better outcomes have been consistently achieved by refining the selection criteria, with a focus on tumor characteristics, including in particular size, number, lobar distribution, and vascular invasion.18–22 A landmark study by Mazzaferro et al.23 published in 1996 set the stage for the current guidelines and policies, which are currently in use to allocate hepatic allografts to those patients with HCC.24
Although the natural history of cirrhosis progressing to HCC has been extensively studied and characterized in the general population,2, 5, 7, 9, 10, 25 the relationship between HCC recurrences and the primary liver disease is unknown after liver transplantation. We hypothesized that the primary hepatic disease underlying the development of cirrhosis and subsequent HCC would be associated with the risk of recurrent HCC after transplantation. To our knowledge, this is the first report to directly examine the impact of hepatitis C virus (HCV) on the recurrence of HCC after liver transplantation.
Patient Population
A retrospective review was conducted of all primary liver transplants performed at our center from May 1995 through June 2004. The pathology reports from the native livers of 727 recipients were examined for the presence of HCC. There were 71 liver transplant recipients with histopathological evidence of HCC. These patients were then divided into 2 groups on the basis of HCV status, which was determined by anti-HCV with at least one positive HCV RNA before transplantation. Group 1 (n = 37) consisted of 28 men and 9 women with a mean age of 53.8 ± 8 years, that were both HCV positive and HCC positive. Group 2 (n = 34) comprised 26 men and 8 women with a mean age of 60.5 ± 8.2 years, all of whom were HCV negative and HCC positive. The data points coded for analysis included number of tumors, tumor size, presence of vascular invasion, lobe involvement, recipient demographics, donor factors, pretransplantation HCC therapy, rejection episodes, and documented HCC recurrence. All recipients received a triple-based immunosuppression regimen consisting of tacrolimus, mycophenolate mofetil, and corticosteroid taper after the same dosing protocols, regardless of HCV status.
Data Analysis
SPSS 13.0 for Windows statistical software package was used for data analysis (SPSS, Chicago, IL). χ2 test was performed to compare groups in terms of gender, donor type (dead vs. living), Milan criteria status, vascular invasion, tumor differentiation, and tumor stage (Table 1). The Milan criteria subgroups were based on actual pathology from the liver after removal. There were only 7 (2 HCV positive, 5 HCV negative) patients (9.9%) with tumors outside of the Milan criteria on the basis of preoperative imaging. None of these patients had evidence of vascular invasion or extrahepatic metastasis. Patients that were outside of Milan criteria were transplanted at their Model for End-Stage Liver Disease (MELD) score without the benefit of exceptional MELD.
|Group 1
|Group 2
|P value
|Recipient age (yr)
|53.8 ± 8.0
|60.5 ± 8.2
|Gender (male/female)
|Donor type (deceased/living)
|Donor age (yr)
|45.8 ± 19
|47.9 ± 20.5
|Follow-up time (months)
|37.1 ± 23
|43.8 ± 30
|Rejection episodes
|12 (32.4%)
|12 (35.3)
|Pretransplant HCC treatment
|8 (21.6%)
|7 (20.6%)
|Hepatitis B coinfection
|20 (54.1%)
|7 (20.6%)
|No. of tumors
|1.84 ± 1.1
|1.91 ± 1.2
|Exceeds Milan criteria
|14 (37.8%)
|12 (35.3%)
|Vascular invasion
|6 (16.2%)
|6 (17.6%)
|Lobe involvement (single/multiple)
|Incidental HCC
|13 (35.1%)
|15 (44.1%)
|Differentiation (well/moderate/poor)
|Tumor stage (I/II/III/IV)
|Largest tumor size (cm)
|3.8 ± 2.2
|3.4 ± 3.0
Tumor size, recipient age, donor age, MELD score, and number of tumors were compared with Student's t test. MELD score was calculated from actual laboratory values on the day of transplantation. Kaplan-Meier analysis was used to compute overall patient and tumor-free survival. Cox regression analysis was performed to identify the independent predictors associated with tumor recurrence. All potentially confounding variables were examined individually in a regression model along with HCV status. All variables that resulted in a ±10% change in the adjusted hazard ratio from the crude hazard ratio, for tumor-free survival when associated with HCV, were included in the final model. HCC recurrence was defined by irrefutable computed tomographic or magnetic resonance imaging, radiographic presence, histopathological evidence, or a combination of these. Incidental HCC, for our purposes here, occurred in patients without a confirmed diagnosis of HCC before transplantation. However, all but 10 (3 HCV positive, 7 HCV negative) patients (14.1%) had increases in alfa-fetoprotein levels, suspicious lesions on preoperative imaging, or both. Rejection episodes were calculated from biopsy-confirmed pathology reports.
Patient Characteristics
There were no statistically significant differences between the 2 groups, with the exception of recipient age and the presence of hepatitis B (HBV) coinfection (Table 1). The patients in group 2 were significantly older than those in group 1. There was a significantly larger number of patients with HBV coinfection in group 1. However, infection with HBV was not a significant predictor for HCC recurrence. There were no statistically significant differences in the types of HCC treatment before transplantation between the 2 groups. Resection was performed in 1 patient in group 1 and 2 patients in group 2. Other forms of treatment included radiofrequency ablation (n = 6 in group 1, n = 2 in group 2), chemoembolization (n = 0 in group 1, n = 2 in group 2), alcohol ablation (n = 0 in group 1, n = 1 in group 2), and radiation (n = 1 in group 1, n = 1 in group 2). The causes of cirrhosis in the HCV-negative group were as follows: autoimmune, 1 (2.9%); cryptogenic, 9 (26.5%); hemochromatosis, 1 (2.9%); hepatitis B, 3 (8.8%); Laennec, 13 (38.2%); nonalcoholic steatohepatitis, 4 (11.8%); and nonresectable HCC without cirrhosis, 3 (8.8%).
Treatment of HCV with interferon (IFN) did not have an impact on tumor recurrence in this study population. A total of 16 patients (43.2%) received IFN before transplantation; 21 patients (56.8%) did not. HCC recurrence occurred in 7 of 16 patients treated with IFN-α, compared with 5 of 21 patients without IFN treatment (P = 0.176). After transplantation, 26 patients experienced HCV recurrence as determined by histological criteria. The mean maximum histological activity index score was 5.67 ± 2.4, and the mean maximum fibrosis score was 1.5 ± 1.3. IFN treatment was offered to 13 patients after transplantation. HCC recurrence was present in 5 of 13 of those who were treated and in 7 of 24 of those who were not treated (P = 0.413). More importantly, tumor-free survival (P = 0.420) and patient survival (P = 0.409) did not differ between those who received IFN and those who did not.
Tumor Characteristics
The tumor characteristics of both groups were similar in terms of number of tumors, Milan criteria status, vascular invasion, incidental HCC, differentiation, and largest tumor size (Table 1). There were a statistically significant greater number of patients with multilobar tumor involvement in the HCV-negative group. In the subgroup analysis, based on the Milan criteria, the 2 groups were similar with the exception of lobe involvement. The patients outside of the Milan criteria who were HCV negative had a far greater number of multilobar tumors (Table 2).
|Within Milan criteria
|Outside Milan criteria
|Group 1 (n = 23)
|Group 2 (n = 22)
|P value
|Group 1 (n = 14)
|Group 2 (n = 12)
|P value
|Largest tumor size (cm)
|2.4 ± 1.0
|2.1 ± 1.1
|5.2 ± 2.0
|6.3 ± 4.0
|Vascular invasion
|2 (8.7%)
|1 (4.5%)
|4 (28.6%)
|5 (41.7%)
|Lobe involvement (single/multiple)
|No. of tumors
|1.4 ± 0.7
|1.3 ± 0.6
|2.6 ± 1.3
|3.0 ± 1.1
Patient Survival
The HCV-positive population had a far lower patient survival rate by Kaplan-Meier analysis (Fig. 1). Patient survival in group 1 at 1, 3, and 5 years was 81.1%, 57.4%, and 49.3%, respectively, compared with the 94.1%, 82.8%, and 76.4% in group 2 (P = 0.049). There were a total of 15 deaths in group 1 from myocardial infarction (n = 2), sepsis (n = 3), intracranial bleeding (n = 1), recurrent HCV (n = 1), metastatic HCC (n = 7), and cerebral vascular accident (n = 1). In group 2, there were 8 deaths, caused by myocardial infarction (n = 2), sepsis (n = 1), metastatic HCC (n = 4), and cerebral vascular accident (n = 1).
Tumor-Free Survival
Tumor-free survival in group 1 at 1, 3, and 5 years was 70.3%, 43%, and 36.8%, respectively, vs. 88.1%, 73%, and 60.8% in group 2 (Fig. 2). Twelve patients (32.4%) developed HCC recurrence in the HCV-positive population, compared with 6 patients (17.6%) in the HCV-negative population. This did not achieve statistical significance. In the HCV negative group, 3 of the 6 recurrences were within the liver compared with 9 of 12 in the HCV-positive group (P = 0.294). In a subgroup analysis, tumor-free survival was further examined by stratifying the patients on the basis of Milan criteria. Group 1 patients outside of Milan criteria had a far lower rate of recurrence-free survival (Fig. 3). By contrast, there was no marked difference in tumor-free survival between group 2 patients stratified according to Milan criteria (Fig. 3). Moreover, Cox regression analysis identified HCV infection and vascular invasion as significant independent predictors of tumor-free survival (Table 3).
|Relative risk
|P value
|Hepatitis C virus
|Vascular invasion
Liver transplantation has emerged as an accepted modality for the treatment of HCC.24, 26, 27 Poor outcomes reported in earlier series of liver transplants for HCC demonstrated the need for better selection criteria to improve survival.28 To this end, recipient and tumor characteristics such as size, number, lobar distribution, and vascular invasion have been extensively studied.29–33 In 1996, Mazzaferro et al.23 reported excellent outcomes for patients with small HCCs. Their selection criterion was limited to patients with unresectable (defined either anatomically or by a limited hepatic reserve) single tumors <5 cm, or patients with up to 3 tumors, the largest of which was <3 cm. Their promising results have been validated by other reports.34–38 Wide acceptance of what is now known as the Milan criteria eventually led to the United Network for Organ Sharing (UNOS) modification of organ allocation policies for HCC in 1998.24, 39 Whether the Milan criteria, and the resulting UNOS policies, are too restrictive has been a controversial issue without a clear resolution.34, 39–42
Our results suggest the Milan selection criteria may be too limiting, preventing the benefits of transplantation from being extended to selected patients with larger tumors. This study showed a marked difference in tumor-free survival for patients with HCV and HCC when they were stratified according to the Milan selection guidelines. However, these guidelines were not able to predict a statistically significant survival difference for those patients whose tumors were not associated with HCV infection. This suggests that the Milan criterion loses predictive power when applied to patients without HCV infection. A plausible explanation for this stems from the characteristics of the patient population that was the basis for the Milan criteria. Of the 48 patients in the study of Mazzaferro et al.,23 45 (95%) had HCV-associated cirrhosis.23 Cirrhosis caused by other etiologies was not evaluated.
The molecular mechanism underlying HCC is currently unknown. The activation of cellular oncogenes, reactivation of tumor suppressor genes, overexpression of growth factors, possibly telomerase activation, and DNA mismatch repair defects may contribute to the development of HCC.43 Many studies have indicated that HCV plays a role in the development of HCC through various mechanisms.7–10 From our clinical standpoint, this study suggests a marked difference in the pattern and aggressiveness of HCC recurrence in a cohort of patients with HCV-HCC exceeding the Milan criteria. This is evident in patient survival and tumor-free survival outcomes. Whether this stems from the biological behavior of HCV is unknown.
It is well established that cirrhosis from any cause is a risk factor for the development of HCC.2, 44 In the general population, HCV-associated cirrhosis is shown to carry the highest risk of HCC development, with an estimated rate as high as 7.8–28% at 5 and 10 years from the diagnosis of cirrhosis.7 Recurrence of HCV after liver transplantation is a universal event, with most patients showing some degree of fibrosis and precirrhotic changes by 5 years.45 In the general population, progression to clinically important hepatitis and cirrhosis related to HCV infection is an indolent process that takes, on average, 10 and 21.2 years, respectively.46 In contrast, after transplantation, progression to cirrhosis is an accelerated process attributable to the presence of the viral infection in the background of immune suppression.47, 48 Perhaps the accelerated progression of histopathological changes associated with viral infection under immunosuppression is also related to an accelerated HCC tumor recurrence.49 This notion is supported by our results, which indicate that hepatitis C is an independent significant predictor of HCC recurrence in Cox regression analysis.
Our results demonstrate vascular invasion and hepatitis C to be statistically significant independent predictors of tumor recurrence and survival. The patients in group 2 were significantly older and had significantly more bilobar distributions of tumor. Interestingly, this cohort had a favorable outcome when compared with the patients in group 1, despite having a higher prevalence of factors that typically predict poorer outcomes. Certainly, a limitation of this study is the small number of patients, which prevents extensive analysis of tumor characteristics as a risk factor for recurrence.
Considering that study of Mazzaferro et al.23 was essentially limited to patients with HCV, and that HCV is an independent variable for poor prognosis, application of the Milan criteria to patients with HCC that is not associated with HCV may preclude them from the survival advantage offered by transplantation. With the acknowledgment of the limitations of this study, in particular the inherent bias of a retrospective study and the relatively small sample size, we believe that there may be a benefit in a careful and methodical expansion of the Milan criteria for HCC in the non-HCV setting. Further studies are needed to confirm these findings and to address the specific extent of any expansion under consideration. 4
- 1Hepatocellular carcinoma: an epidemiologic view. J Clin Gastroenterol 2002; 35(5 Suppl 2 ): S72–S78..
- 2Etiology, natural history and treatment of hepatocellular carcinoma. Antiviral Res 2003; 60: 145–150., .
- 3British Society of Gastroenterology Guidelines for the diagnosis and treatment of hepatocellular carcinoma (HCC) in adults. Gut 2003; 52( Suppl 3): iii1–iii8.,
- 4Hemochromatosis-associated mortality in the United States from 1979 to 1992: an analysis of multiple-cause mortality data. Ann Intern Med 1998; 129: 946–953., , , , .
- 5Hepatocellular carcinoma [review]. Lancet 2003; 362(9399): 1907–1917., , .
- 6Epidemiology, risk factors, and natural history of hepatocellular carcinoma. Ann N Y Acad Sci 2002; 963: 13–20., , , , , .
- 7Natural history of compensated viral cirrhosis: a prospective study on the incidence and hierarchy of major complications. Gut 2004; 53: 744–749., , , .
- 8A high prevalence of antibody to the hepatitis C virus in patients with hepatocellular carcinoma in Japan. Cancer 1991; 67: 429–433., , , , , , et al.
- 9Natural history and risk factors for progression of hepatitis C virus disease and development of hepatocellular cancer before liver transplantation. Liver Transpl 2003; 9: S14–S20..
- 10Risk factors for hepatocellular carcinoma among patients with chronic liver disease. N Engl J Med 1993; 328: 1797–1801., , , , , , et al.
- 11Liver transplantation for malignant tumours. Baillieres Clin Gastroenterol 1989; 3: 787–797., .
- 12Liver transplantation for small HCC in cirrhosis. Transpl Int 1992; ( 5 Suppl 1): S215–S216., , , , , , et al.
- 13Primary hepatic cancer—the role of limited resection and total hepatectomy with orthotopic liver replacement. Hepatogastroenterology 1988; 35: 316–320., , , , , , et al.
- 14
- 15Role of liver transplantation in cancer therapy. Ann Surg 1985; 202: 401–407., , , .
- 16Controversies in patient selection for liver transplantation. West J Med 1993; 159: 586–593., .
- 17Is liver transplantation justified for the treatment of hepatic malignancies? Arch Surg 1990; 125: 1261–1266., , , , , .
- 18Liver resection versus transplantation for hepatocellular carcinoma in cirrhotic patients. Ann Surg 1993; 218: 145–151., , , , , .
- 19Role of liver transplantation in the treatment of hepatocellular carcinoma. Semin Surg Oncol 1993; 9: 337–340., .
- 20Liver transplantation for primary hepatocellular carcinoma: tumor size and number determine outcome. J Hepatol 1993; 18: 226–234., , , , , , et al.
- 21Experience of orthotopic liver transplantation and hepatic resection for hepatocellular carcinoma of less than 8 cm in patients with cirrhosis. Br J Surg 1995; 82: 253–256., , , , , , et al.
- 22Liver transplantation and hepatocellular carcinoma [review]. Semin Surg Oncol 1996; 12: 212–216., .
- 23Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 1996; 334: 693–699., , , , , , et al.
- 24Liver transplantation for malignancy [review]. Oncologist 2005; 10: 269–281., .
- 25Hepatocellular carcinoma [review]. Lancet 1999; 353(9160): 1253–1257., .
- 26Current status of liver transplantation for hepatocellular cancer. Am J Surg 2002; 183: 309–316..
- 27The outcome of liver transplantation in patients with hepatocellular carcinoma in the United States between 1988 and 2001: 5-year survival has improved significantly with time. J Clin Oncol 2003; 21: 4265–4267., , , .
- 28Hepatocellular carcinoma: can it be considered a controversial indication for liver transplantation in centers with high rates of hepatitis C? Liver Transpl 2002; 8: 1020–1027., , , , , , et al.
- 29Selection criteria for liver transplantation in early-stage hepatocellular carcinoma with cirrhosis: results of a multicenter study. Liver Transpl 2001; 7: 877–883., , , , , , et al.
- 30Liver transplantation for hepatocellular carcinoma. Ann Surg 2001; 233: 652–659., , , , , .
- 31Influence of tumor characteristics on the outcome of liver transplantation among patients with liver cirrhosis and hepatocellular carcinoma. Liver Transpl 2001; 7: 631–636., , , , , , et al.
- 32Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis. Hepatology 2001; 33: 1080–1086., , , , , , et al.
- 33Liver transplantation for hepatocellular carcinoma: a registry report of the impact of tumor characteristics on outcome. Ann Surg 1998; 228: 479–490..
- 34Liver organ allocation for hepatocellular carcinoma: are we sure? Liver Transpl 2003; 9: 693–696., .
- 35Indications and role of liver transplantation for malignant tumors. Oncologist 1997; 2: 164–170., , , .
- 36Liver transplantation for early-detected, multifocal hepatocellular carcinoma. Br J Surg 2001; 88: 1194–1195., , , , , .
- 37Impact of histological grade of hepatocellular carcinoma on the outcome of liver transplantation. Arch Surg 2001; 136: 25–30., , , , , , et al.
- 38Surgery and transplantation for hepatocellular cancer. Liver Transpl 2000; 6(6 Suppl 2 ): S16–S22., .
- 39Liver transplantation for hepatocellular carcinoma. Best Pract Res Clin Gastroenterol 2005; 19: 147–160., , .
- 40Can we expand the indications for liver transplantation among hepatocellular carcinoma patients with increased tumor size? Transplantation Proceedings 2003; 35: 1818–1820., , , , , , et al.
- 41Liver transplantation for hepatocellular carcinoma: expanding special priority to include stage III disease. Arch Surg 2005; 140: 459–464., , , , , , et al.
- 42Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival. Hepatology 2001; 33: 1394–1403., , , , , , et al.
- 43Hepatocellular carcinoma in HCV-infected patients awaiting liver transplantation: genes involved in tumor progression. Liver Transpl 2004; 10: 607–620., , , , , , et al.
- 44The European approach to hepatocellular carcinoma. Hepatogastroenterology 2002; 49: 12–16., .
- 45Liver transplantation for hepatitis C virus related cirrhosis. Baillieres Best Pract Res Clin Gastroenterol 2000; 14: 307–325., .
- 46Hepatitis C [review]. Ann Intern Med 1996; 125: 658–668., , .
- 47Host and donor risk factors before and after liver transplantation that impact HCV recurrence [review]. Liver Transpl 2003; 9: S44–S47..
- 48
- 49De novo hepatocellular carcinoma in a hepatic allograft with recurrent hepatitis C cirrhosis. Liver Transpl Surg 1999; 5: 81–81., , , , , .


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Fr. Carmel's Homily Part 3 of 3 12.21.08
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In part 3 of 3, Fr. Carmel completes his explanation of today's readings.
Fr. Carmel Polidano Homily
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Countries Pledge to Curb Deadly Pollution at Historic Washington, D.C. Event
Washington, D.C.—Government officials from Egypt, Germany, Nigeria and Norway joined top musicians from around the world to commit to improving people's health by ending pollution. Pollution contributes... Show More +
Time to End Routine Gas Flaring
Anita Marangoly George, Senior Director of the World Bank Group's Energy and Extractives Global Practice, called for an end to routine gas flaring by 2030."It is time to end this industry practice," she... Show More +
Transport: Sector Results Profile
Bank Group ContributionThe World Bank's engagement in transport projects has returned to pre-crisis levels, after tripling its commitments between FY04 and FY13. The share of lending for the roads and... Show More +
Developing Competitiveness: Creating Jobs and Reducing Inequality
Bank Group ContributionMore than $1.45 billion in competitiveness projects have been sourced from the competitiveness programs through 27 projects under active implementation, almost entirely sourced from... Show More +
High Above Earth, Satellites Help Direct Ground-Breaking Development Work
The technology is especially useful in areas where conflicts, strife, or wars make it difficult to gather data, and it can provide wide-scale observations that cross country borders. A single satellite... Show More +
World Bank Launches Initiative on Migration, Releases New Projections on Remittance Flows
WASHINGTON, April 19, 2013 – The World Bank today announced the establishment of the Global Knowledge Partnership on Migration and Development (KNOMAD), envisioned to become a global hub of knowledge and... Show More +
Extractive Industries Transparency Initiative: Results Profile
Bank Group ContributionSince its launch, EITI has seen great momentum and traction, with rapid uptake in most regions. This record of accomplishment is due in large part to the World Bank/MDTF technical... Show More +
What's Next for Sustainable Transport in Cities?
The challenges cities faceOver the two days, the conference topics ranged from sustainable urban planning to making informal transport work for the majority, to creating safe commuting choices. Beijing,... Show More +
Developing countries to receive over $400 billion in remittances in 2012, says World Bank report
WASHINGTON, November 20, 2012 – Remittance flows to the developing world are expected to exceed earlier estimates and total $406 billion this year, an increase of 6.5 percent over the previous year, according... Show More +
Climate Change Infographic: Avoiding a 4°C Warmer World
Click the image for FULL RESOLUTION.
World Bank & IFC Report Finds Developing Countries Made Significant Progress in Improving Business Regulations
Washington, D.C., October 23, 2012—Local entrepreneurs in developing countries are finding it easier to do business than at any time in the last 10 years, highlighting the significant progress that has... Show More +
Jobs are a cornerstone of development, says World Development Report 2013
Washington, October 1, 2012 -- In developing countries, jobs are a cornerstone of development, with a pay off far beyond income alone. They are critical for reducing poverty, making cities work, and providing... Show More +
World Bank Group and IMF to Hold 2015 Annual Meetings in Lima, Peru
The 2015 Annual Meetings of the World Bank Group and the International Monetary Fund will take place in Lima, Peru, in October 2015, following a vote by the Boards of Governors of the two institutions.... Show More +
Rethink Role of State in Finance, says World Bank
Washington, September 13, 2012 – It is time to rethink the role of the state in the financial sector, so that governments can better balance the need for credit and emergency support for banks with measures... Show More +
Severe Droughts Drive Food Prices Higher, Threatening the Poor
WASHINGTON, August 30, 2012 – Global food prices soared by 10 percent in July from a month ago, with maize and soybean reaching all-time peaks due to an unprecedented summer of droughts and high temperatures... Show More +
Food Price Volatility a Growing Concern, World Bank Stands Ready to Respond
"We cannot allow short-term food-price spikes to have damaging long-term consequences for the world's most poor and vulnerable" – World Bank Group President Jim Yong KimWASHINGTON, July 30, 2012—Given... Show More +
World Bank Group President Jim Yong Kim Remarks at the Opening Plenary of the International AIDS Conference 2012
"Ending AIDS and Poverty"Your Excellencies and honored guests, ladies and gentlemen, colleagues and friends,As we look back on the history of this epidemic, it is hard to say that there is any one... Show More +
World Bank Sees Warning Sign in Gas Flaring Increase
WASHINGTON DC, July 3, 2012 — New data showing a two-billion cubic meter increase in flared gas in 2011 over the previous year is a warning that efforts to reduce flaring need to be sustained and even... Show More +
Statement of World Bank Group President Jim Yong Kim
I am honored to assume the Presidency of the World Bank Group. I do so at a moment that is pivotal for the global economy, and defining for the World Bank as an institution.The global economy remains highly... Show More +
Transcript of Media Roundtable
MR. MILLS: Good afternoon, everyone. Thanks for joining us for this roundtable. My name is Richard Mills. I know many of you; welcome. I... Show More +


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Blue Magic Carpet Stain & Spot Lifter
Blue Magic's Carpet Stain & Spot Lifter requires a mere wait time of 10 to 30 seconds to tackle stains. Unfortunately, that's where the magic ends. This solution did a good job removing most stains in our test, but struggled to lift fresh gravy and wine spills. bluemagicusa.com.
Reviewed: November 2010
Price When Reviewed: $5.99 for 23 oz.
- Easy to use
- Very short wait time
- Struggled to remove fresh gravy and red wine stains
What do you think?
Craftsman C3 1/2-Inch Heavy-Duty Drill
This 19.2-volt beast will help you tackle tough projects quickly and effectively.
BLACK+DECKER MATRIX 20V MAX Lithium Drill/Driver
Compatible with many extra attachments, this drill is a smart pick for those who want more diversity in their toolkits.
BLACK+DECKER 20V MAX Lithium Drill/Driver with AutoSense Technology
This drill's AutoSense Technology will recognize when a screw is in place, and then engage by itself — eliminating any speculation or...
RYOBI 18V One+ Lithium-Ion Drill/Driver Kit
The RYOBI 18-volt lithium-ion kit is a good addition to any toolbox.
More From Home & Garden Products


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I have 2 male weimaraner puppies left. Tails docked dew claws removed. Not registered.
Jun 30 -
Clarksville :
Franklin - Dogs & puppies
I have Weimaraner pups that will be ready aug.12.2015 their tales have been docked and declaws removed they will have all their shots and be dewormed again and they will come with their akc papers
Jun 21 -
Atlanta :
Toccoa - Dogs & puppies
We currently have a litter of 5 silver pups. We are currently accepting deposits to hold ($150) They will be current on vaccinations and de-worming. Tails are docked and dew-claws removed. Born on 05.28.2015 and ready on 07.23.15. Parents and grandparents on site. Weims make terrific pets and hunters at the same time, very low shedders, extremely intelligent, and very low odor. $650.00
More ...
Jun 16 -
Nashville :
Westmoreland - Dogs & puppies
I have 7 AKC weimaraner puppies for sale I have 2 blue males (1 sold) 1 blue female, 2 silver gray males and 2 silver gray females. I have both parents on site.They will be up to date on shots, dew claws removed and tails docked will need $100 deposit for holding the puppy location Salyersville, Ky call or text (606) 496 6831 Thanks!
Jun 16 -
Huntington-Ashland :
Salyersville - Dogs & puppies
we are looking to rehome our beautiful fur baby, we have 5 children and our precious Scooby needs more room to run and more attention if you are a lover of this breed you already know they are very loyal. he is crate trained and house broken completely.
Jun 5 -
Cincinnati :
Fairfield - Cats & kittens
We have two litters of Silver and Blue Weimaraners. One Litter was born on April 17, 2015 & April 21, 2015. We have silver females, 2 Blue Females, and 4 Blue males. Their tails have been docked and dew claws removed. They have been socialized around other dogs and children. Your new fur family member will come to you with their CKC Registration puppy paper, shot record documenting ...
May 27 -
Clarksville :
Glasgow - Dogs & puppies
AKC weimaraner born 4-23-2015 tails and dew claws done, will be utd on shots and worming, papers in hand, full reg beautiful pups call now 1-606-738-6169 thank you
May 26 -
Huntington-Ashland :
Olive Hill - Dogs & puppies
2 males 2 females....
akc registered
Vet checked
all paperwork given at time of transaction
May 26 -
Louisville :
Lexington - Dogs & puppies
Beautiful male Weimaraner. Just turned 1 year old. Neutered. Trained and house broken. Very smart and loving.
Not an easy choice for us to sell but recent changes in our schedule makes it difficult for us to spend as much time with him as we'd like. Very playful outside. Calm when he is inside. All shots up to date.
This ad was posted with the eBay Classifieds mobile app.
May 26 -
Cincinnati :
Mason - Dogs & puppies
AKC pups born 4-23-2015 tails and dew claws done, will be utd on shots and worming at time of pickup. Beautiful pups just waiting for you to call 606-738-6169 papers when you pickup your pup thank you
May 25 -
Huntington-Ashland :
Olive Hill - Dogs & puppies
Beautiful, silver Weimaraner puppies for sale!!! Puppies are $500/each and a deposit of $250.00 is required to reserve a puppy. Both parents are AKC Registered and onsite. Puppies were born 5/17/15. Puppies have their tails docked, dew claws removed, first shots, and vet health exam before going to their forever homes. Please visit our Facebook page, Ridley's Weims, for more information, ...
May 20 -
Chattanooga :
Dalton - Dogs & puppies
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text:
Originally written on Fox Sports | Last updated 11/21/12
Corey Hawkins scored 29 points and J.T. Adenrele added 19 to lead UC Davis to an 87-76 victory against Sacramento State on Tuesday night. Ryan Simpkins added 15 points and Ryan Howley seven points and 15 rebounds for the Aggies (1-2), who overcame a 33-24 halftime deficit. Dylan Garrity scored 22 points and John Dickson 18 for the Hornets (3-1), who shot just 35.8 percent (24 of 67) from the floor. A 22-3 run over a 7:45 second-half stretch gave UC Davis control. Tyler Les hit two 3-pointers during the surge, which was punctuated by a Hawkins shot from behind the arc that gave the Aggies a 50-38 lead with 10:50 remaining. Sacramento State, which went scoreless for 4:15 as UC Davis rallied, did not get closer than five points the rest of the way.
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Larimer County Offices, Courts & District Attorney are closed Friday, July 3 for Independence Day
Landfill, Hazardous Waste and Recycle Center are open Friday, July 3 but closed Saturday, July 4
Landfill Business Office are closed July 3 & 4 Critical services at Larimer County will not be disrupted by this closure.
Parts of the Larimer County Virtual Courthouse website may be unavailable during maintenance on Tuesday, June 30 from 5 - 7 p.m.
The Wildfire Safety Program recently compiled a county-wide subdivision wildfire hazard assessment. Larimer County Wildfire Safety staff conducted assessments on a number of subdivisions and development areas.


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Large Shop To Let (Upton Lane)
We are pleased to offer this spacious ground floor office to let on Upton Lane, Forest Gate. The shop has various opportunities with plenty of foot fall along Upton Lane. The shop is in a great condition and has been recently renovated. The prope
- Agency
- Date available: 09 Jun 2015


text: TOP 10 Top 10 Travel Top 10 Vacations That Will Make You A Better Man Back to Top ▲ Top 10 Vacations That Will Make You A Better Man 1 Survival Vacation Share on Facebook Share on Twitter 0 Shares Thinkstock When it comes right down to it, even desk-jockey city dwellers want to know how to handle themselves in the wilderness. That's because the skills translate anywhere, from helping you locate the north side when coming out of the subway to doing advanced first aid in an emergency. Just how gnarly the experience is depends on the program. At the entry level, there's Outward Bound. The Boulder Outdoor Survival School will teach you the "old ways" of living. Or you could get serious and do a year in Patagonia with the National Outdoor Leadership School.Go here: Rocky Mountains; Patagonia; India; Pacific Northwest. TOP 10 9 8 7 6 5 4 3 2 1 Comments Show Comments More Like This Travel Guide Rent The Ultimate Vacation Home Read More Fine Living News Trending News: Getting To Europe Just Got Insanely Cheap Read More Fine Living Galleries The 32 Reasons Every Man Needs To Visit Chicago In The Next 365 Days Read More Entertainment Galleries 10 Guaranteed Ways Your Weekend Could Have Been Better Read More Play The 30 Weirdest American Festivals You Should Attend This Summer Read More Top 10 Entertainment 10 Times Movie Sequels Rewrote Their Series' History Read More Promoted Around the Web Special Features Special Feature Over 100 Ways To Make This The Most Jaw-Dropping Year Of Your Life Read More Special Feature 100 Ways To Look Better Than You Do Now. Smooth Up, Man. Read More Special Feature From Dating To Fitness, Over 75 Ways Men Are Winning 2015 Read More ad


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Our next show is our Spring show on Saturday, April 18th, 2015 at
The Clarion Inn and Suites at 50 Orchard Park Drive (I-385 @ exit 39)
Greenville, SC 29615
Plus 20+ tables of the area's best comic book and sports card dealers selling both new and vintage comic books and sports cards. Plus supplies and much much more!
10am - 4pm
For show info:


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IU to make major donation announcement Friday
Thu., Jun. 4, 2015
Hoosiers head home after 4-2 loss to Maryland #iubase
Sat., May. 23, 2015
Live chat transcript: IU baseball, women's basketball
Fri., May. 22, 2015
Six Indiana teams earn APR recognition
Wed., May. 20, 2015
Sig Ep holds off Black Key Bulls to win Little 500
Sun., Apr. 26, 2015
Little 500: Kappa Alpha Theta wins back-to-back titles
Fri., Apr. 24, 2015
Fri., Apr. 24, 2015
With help from YouTube, here are highlights of Indiana's class of 2010 signees on the offensive side of the football.
Kofi Hughes
Antonio Banks
Matt Perez
Xavier Whitaker
Tim O'Conner
Logan Young
Bill Ivan
No available videos for Leneil Himes, Paul Phillips or Cody Evers.
I am watching CBS Sports TV (formerly known as CSTV). Right now, we're watching a feature on New Mexico's Pit. In a few, Tom Lemming (think he'll be wearing green and gold today?) will be on, as will Andre Kates.
Kates, a JUCO cornerback, told Scout.com's John Decker a few minutes ago he'll sign with Indiana. He was actually the first commit in the class of 2010 for Indiana, but wavered once other schools became interested.
He visited Miami last weekend and also is interested in Oklahoma State and New Mexico.
11:35 A.M. UPDATE: Still no word on Kates. Actually, not a single signing shown yet. Could be a while. Yikes.
Scout.com has photo of Kates in IU gear. And still no word on TV about him.
NOON UPDATE: Yeah, it does not look like this is happening. They're switching to some high school football year in review show.
Jody Demling of the Louisville Courier Journal has reported that running back Miles Simpson of Simon Kenton High School in Independence, Ky. has chosen Kentucky over Indiana and Illinois. Simpson has rushed for over 2,200 yards and 38 touchdowns in each of the past two seasons.
Indiana has already announced numerous signings, however, including those of Marlandez Harris, Matt Perez, Cameron Cole, Kofi Hughes, Paul Phillips, Cody Evers, Matt Zakrzewski, Brian Williams, Bill Ivan, Logan Young, Drew Hardin, Xavier Whitaker, Pete Bachman, Tim O'Conner, Ishmael Thomas, Ryan Phillis, Chase Hoobler, Antonio Banks, Shaquille Jefferson, Jack Denton, Leneil Himes, and Harrison Scott.
The Hoosiers already had letters of intent from junior college signees Jeff Thomas and Lenyatta Kiles. Defensive back Andre Kates will announce his decison at 11 a.m. on Tom Lemming's signing day show on CSTV.
Doug Crusan (77) looks on as Larry Csonka talks to Miami Dolphin teammates during an exhibition game. Jim Bourdier | Associated Press
Indiana may not be in the running for any five-star blue chips, but that's not to say that signing day will be without intrigue in Bloomington.
The Hoosiers' incoming class could include anywhere from 24 to 26 players, depending on the signing day decisions of two players who could be among the stars of the class.
Cornerback Andre Kates, a three-star cornerback from the ASA Institute, a junior college in Brooklyn, N.Y., verbally committed to Indiana in May. He's never formally decomitted from the Hoosiers, but he got a lot more attention after winning Junior College Player of the Year honors from Triumphant Sports. He took visits to Oklahoma State and Miami in the last two months, and said Tuesday that he will chose between those schools, New Mexico and Indiana at 11 a.m. Wednesday morning on recruiting guru Tom Lemming's signing day show on CSTV. (more…)
Tom Crean says he doesn't have enough guards right now.
This may surprise the many who send the second-year coach e-mails and comment on blogs about the team's lack of post presence, but Crean said in order for the Hoosiers to play the uptempo style he envisions he needs more perimeter players.
Through Monday, the Hoosiers ranked sixth in the Big Ten in scoring in all games, averaging 69.5 points per game. In conference games only, however, the Hoosiers are eighth with 61.4 points per game. That dip coincides directly, of course, with the season-ending knee injury to star freshman guard Maurice Creek. (more…)
Though sophomore guard Matt Roth dressed for the first time since breaking his foot in Puerto Rico in November, Tom Crean said Monday in the Big Ten teleconference that there was no chance he was going to play.
"Him dressing the other day was good for him, it was good for our team," Crean said. "To have him out there. I wouldn't have played him, even for a half-court shot, which we joked with him the night before about being in position to do that, but there's no way we would do that until he's totally cleared. Hopefully we'll see more this week. Hopefully he'll be able to be involved in practice sometime this week."
The clock, of course, is running for Roth. Crean said earlier this season he would apply for a medical hardship if he was out until February. That's still up for debate, Crean said. (more…)
No reason to have anymore heroes...These will [...]
That and they frequently beat 'my' team. [...]
Fun stories. That's the same reason I could never get on board with [...]
oops. ...own [a] personally autographed... I know coachv would b [...]
I know lots of people whose rooting habits are similar to yours. For [...]
Nothing like a good "back story," unless it's your nickname in prison [...]
I got to know Madison Baumgarner a little bit when he played at South [...]
Find Kentucky basketball coverage on VaughtsViews.com - Find Notre Dame football coverage on NDInsider.com. © Hoosier Times Inc., all rights reserved.


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Originally written on Double Coverage Football | Last updated 12/27/12
Bowling Green vs. #24 San Jose State RFK Stadium, Washington, DC Thursday, December 27th, 3:00 PM on ESPN The Military Bowl began as the EagleBank Bowl in 2008 as an opportunity to showcase the ACC, Conference USA, and service academy teams to fans in the DC area. For the first time ever, this year's game won't feature any of the tie-ins, instead plucking Bowling Green from the MAC and San Jose State from the WAC. It's the Falcons' fifth bowl appearance this decade after missing the postseason from 1992 to 2002. The Spartans are making their first bowl appearance since 2006, and second since 1990. Brendan's Pick: Both teams are coming into DC hot; the Spartans have won six straight and the Falcons have won seven of eight. Common wisdom tells us this game will come down to how well David Fales and the Spartans record-breaking passing attack will handle Chris Jones and the Falcons stout defense, but common wisdom has been blatantly wrong the last three games so eff...
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Posted almost 2 years ago by admin
Hi Everyone! We will be in Central Philadelphia on August 10th to showcase our latest and coolest software, and will be offering a 2 hours workshop on Cross-platform application development in eC with the Ecere SDK. FOSSCON registration is either free or voluntary 25$ donation, and likewise our workshop is free but donations are appreciated! [...]
Posted over 3 years ago by admin
I have the great pleasure to announce that the official version 0.44 of Ecere, codenamed "Ryoan-ji", is now available. It is the first "official" Open Source release of Ecere (not a draft, or preview). The Windows installer is available at: ... [More]
Posted over 5 years ago by Jérôme
Hi guys.
Some news in the Ecere world:
As you might have noticed, I started updating the website a bit. We have a new front page with a nice big obvious download button, a new mascott (Oliver the Sea Otter - Ollie). There is still quite a bit more refinements to the rest of the web site [...]
Posted about 6 years ago by Jérôme
Lots of pending modifications since 0.44draft1 have been merged into the repository (too many to enumerate all of them!), paving the way for the forthcoming 0.44 release. A second draft version (0.44draft2) is expected within a week. Several ... [More]
Posted over 6 years ago by Jérôme
Well folks it seems Ecere has not been selected as a mentor organization for the Google Summer of Code 2009… Maybe we will try applying again next year. Sorry for all enthusiastic students who were hoping to participate with us.
The list of all ... [More]
Posted over 6 years ago by Jérôme
Today is the mentor organizations application deadline for the Google Summer of Code 2009 program in which Ecere really hopes to participate.
We've put together an ideas list up for prospective students. It's available ... [More]
Posted over 6 years ago by Jérôme
Hello everyone, sorry for the very few updates in the past few months.
Much development has happened lately focused on what has always been the calling for Ecere: a Free Open Source Software status, as well as a greater facility to deploy across multiple platforms.
The next major release (0.44) was to reach these objectives, and I [...]
Posted almost 7 years ago by Jérôme
After a lot hard work, I am pleased to announce the release 0.43 of the Ecere SDK. Download links follow:
For Windows:
Ecere SDK 0.43 for Windows - September 3, 2008 (36 MB)
If you already have MinGW installed on your system (or if you already have an earlier version of the Ecere SDK installed), you can chose [...]
Posted about 7 years ago by Jérôme
I just released Ecere SDK version 0.42.1.
This release features major bug fixes and improvements to the EDA library (Ecere Data Access), support for executables and DLLs compression through UPX, an improved EditBox Undo buffer, important ... [More]
Posted about 7 years ago by Jérôme
I am pleased to announce the release 0.42 of the Ecere SDK, for both Windows and Linux.
It brings a long overdue undo/redo buffer to the IDE's code editor, improved X support, improvements to the IDE and numerous bug fixes.
The new installer for Windows comes with a GCC 4.3 alpha MinGW and should install and compile [...]


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Teaches the intricacies of creating, editing, and publishing professional layouts with InDesign CS3.
Covers all InDesign's tool in depth and offers layout principles for new and experienced users.
"IThis is a wonderful resource for me which I use almost daily in my personal education." —Virginia M.
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