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Rated 4.3 out of 5 by 568 reviewers.
Rated 4 out of 5 by Stef3500 Location, location, location Great hotel in an amazing place. The location is great for entertainment. Near the By ward market, Rideau shopping center. Best hotel near the market. Great pool and gym. This a good Westin. June 8, 2015
Rated 5 out of 5 by Greg97 SPG Recognition at its Best The SPG recognition experience starts the minute you arrive at the Westin Ottawa's front door and are greeted by the friendly and helpful bell staff, continues to the Front Desk services for check-in, and throughout your stay with excellent service and food at Daly's, or if you choose room service. The fitness center is one of the largest and best equipped and maintained that I have encountered in my travels. I am a Road Warrior, and the Westin Ottawa continues to make that road just a little more bearable May 31, 2015
Rated 5 out of 5 by Toronto88 Fun family weekend All hotel staff we encountered were great. Excellent service at Daly's when we went for the brunch buffet...two days in a row. Service from Hilary Read at Daly's on the second day was outstanding. May 21, 2015
Rated 5 out of 5 by dacfo Great hotel and location Great hotel, superb location and very friendly staff. I would highly recommend May 19, 2015
Rated 5 out of 5 by DaveAndLiz Our dream wedding at The Westin Ottawa We had our wedding at the Westin in October 2014 and could not have imagined how incredible it would be. Tia was working with us from the very first day, and at times we felt like she may actually officiate the service just to ensure it was perfect. Every detail was looked after, things we'd never have thought to ask for were already in order before we realized we'd need them. Just over a hundred of our closest friends and family were waited on like they were royalty. The chef prepared an incredible menu, the servers were amazing, and our stay at the hotel was perfect. The only confusing part for our guests was working the elevators, but admittedly, they seem to work better than regular ones, once you figure out how they work. If you want a great escape for the weekend, or you'd like to spend a few days with your entire family getting married, the Westin Ottawa is a great place to do it, and Tia and her team are fantastic. May 13, 2015
Rated 1 out of 5 by Nbknbk I need my money back I visited the shore club resturant for my birthday . I booked before 2 weeks ago via internet . When we arrived at 7 pm we waited 17 min to be seated, then we set on the worst table in resturant , i asked the manager to change the table , he said we cant do any thing this right now. If you like wait 30 min and i will move you some where else, that very bad and i really disappointed from this resturant how they deal with customers. I paid 165$ which is not bad but they should respect private ocations. I need my money back or i need speacial arrangment for next visit May 3, 2015
Rated 5 out of 5 by choysum Exceeded Expectations Was here for a conference. Room facilities were great, responsive staff, excellent food at the conference. Location is fantastic. April 26, 2015
Rated 1 out of 5 by UnsatisfactoryWestin Nickel & Dime Experience This has been the worst Westin I have stayed in. I am a gold Member and expect some benefits - but even non-gold members should be disappointed with these problems. - Local and 1-800 calls - Free? NO - $1.77 + $.22 tax = $1.99 per call - Paper delivered to door? NO - twice in 5 mornings there was some by the elevator I had to go to the lobby to get a paper - when I asked about this at the Gold desk - I was told they stopped delivering to room doors awhile ago - but they could add this to my profile - the problem is my profile already had this listed. Gold member late check out - I asked for late check out - calling from a Gold member floor - and was told I had to call back on the day of check out because they weren't sure of the availability - I reminded them I was a gold member - they apologized and gave me late check out - as I am guaranteed; - in room Television - an ancient old Philips with crappy remote - took over an hour to get the remote delivered when the first one died and I had to call to remind them. - Golf channel listed in Westin "Stay Well: Directory as ch 78 - it does not work - I called the front desk because this was Master's Week - the suggestion was "try the sports channel"! - When my remote was not working I saw an ad on the initial channel about downloading an ap to control the tv - I did this but needed a code to activate the ap - I called the front desk and they had no idea what I was talking about - they called back and said this service was not offered in this Westin; - a cordless phone in the room - the battery didn't hold a charge; - a weight room - yes but down a grungy hallway and an even older tv that got fewer channels than the room and didn't even get the sports channel and with some odd music piped in that had no volume control to turn it off or even down. - a business centre - yes, but you have to swipe a credit card and are charged $5.95 for maximum 15 minutes to even do a search then if you want to print a boarding pass - that's another $1.00 per page!! Unbelievable. I normally love the Westin - I am coming back to Ottawa for 10 days in May and it won't be to the Ottawa Westin - I would recommend you try another hotel brand as well. April 11, 2015

subset: commoncrawl


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Release Date:
July 15, 2013
Kids now can step into the driver's seat to build their very own amusement park in a simulation developed just for them! Kids can choose rides like the Pirate Ship, the Super Coaster, and more as they build a theme park into a huge success! Earn money by playing eight logic and puzzle games, then use the money to keep adding onto your park!
Video Game Condition: New
- Genre: Adventure
- Platform: Nintendo DS
- Publisher: Nintendo
other Info.
- Online Item #: 14237383
- Store Item Number (DPCI): 207-02-1740
- Made in the USA or Imported


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Grandparent Love Tees > Grammy T-Shirts > Grammy Special T-Shirt > Grammy Special Shirt
Our Being a Grammy makes everyday special t-shirt design is a great way to let the world know just how much you love being a Grammy. Features pretty pink frame and tiny pink flowers.
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They have produced a documentary video about ABAT longs.http://www.youtube.com/watch?v=AOOs8MaR1YM&feature=related
yes project, yes project. your pathological lying continues, just like the shorts and just like the mean-spirited human beings that made this video to depict a fiction and to fabricate a story for their own greedy ends. you, the shorts and the makers of this video are cut from the same cloth.you aswipehttp://en.wikipedia.org/wiki/White_Wilderness_(film)


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Tap Here to view the Mobile Optimized TFLN
I didn't notice until this morning that he had a six inch RAT TAIL...
You must be Logged in to post a comment
Did you notice that he was missing a few teeth? Serves you right for taking Cletus home when he should've been watching the trailer.
... I seriously hope you're referring to the hairstyle, and the image that popped up in my mind is much more disturbing.
Pretend it's a padawan braid and he's anakin
You bastard. Those things are as rare as shiny pokemon
I hope you cut it off and left before he woke up.
1:54 Lol. Trailer trash! I choose you!
Business up front, party in the back.
One of my exs had one that was almost 6inches when I met him....but then I cut it off
I pray to God this is fake. Yuck.
3:24...seriously?! Did a yankee gangster wanna be just throw out a y'all????
1:54, I'm thinking of a Seinfeld episode ...
that's only okay if he is ice-t.
I miss the maritimes...
Hahahaa! My brothers and I all rocked the rat tail when we were 5-15 too... I had a nasty 6" one going one summer.
funny that there have been several posts about a rat tail recently, when I have never heard anybody talk about them for years. Not sure about you all but kinda funny they all show up at once
:o ohhhhhhhhhhh that's nasty
a rat tail is like a pony tail on guys but a lot smaller, and kind of looks like (you guessed it) a rat tail. I think i remember justin timberlake tried in all his powers to make it cool again but he just looked like a douchebag, more so than usual.
if he was still asleep, i so would have cut it off
wow ... didn't notice the wog like grease emitting from his pores?
cut it off and beat him sensless with it.
To 3:31 on 9/11: That was my 1st thought, too. So you're not the only one.
hahhahahaha. i could never miss something like that... swinging in the wind...
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FORT MYERS, Fla. -- Earlier this week, principal owner John Henry addressed the media and gave his thoughts on the Red Sox' recent past, present and future.
NEW YORK -- In a season of far too many lows, the Red Sox found another on their way to their worst season in more than four decades.
BOSTON In early August Scott Atchison stood in front of his locker in the Red Sox clubhouse talking about the pain in his elbow and his fear that he may have to undergo what would be season-ending
BOSTON -- Jon Lester turned in a decent outing, but not good enough for a win, as the Red Sox dropped the opener of their three-game series against the Orioles, 4-2, at Fenway Park Friday night.


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November 26, 2014
Real Simple's Maple Pumpkin Pie
June 22, 2014
Sunset Magazine's Beef Roast with Caramelized Clementine Sauce
June 6, 2014
Food Network's Sunny Anderson's Beef Lettuce Wraps + Recipe Link Up
March 19, 2014
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October 28, 2013
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September 11, 2013
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Doobie Brothers w/Michael McDonald, Sunday October 4th, 2015 - Sonoma Music Festival
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KQED Education: Stephanie Syjuco Workshop and Lecture at di Rosa
KQED Education
Thursday, July 12, 2012 from 6:15 PM to 8:30 PM (PDT)
Join KQED and di Rosa for an arts and media workshop focused on the work of Bay Area artist, Stephanie Syjuco, followed by a lecture and reception with the artist in the Gatehouse Gallery at di Rosa in Napa.
Teachers will join KQED Education staff on July 12 to explore media pieces and educator guides related to Stephanie Syjuco and her work, and will receive free admission to a lecture with the artist later that evening, and a wine and cheese reception. Don't miss this fun summer opportunity to meet one of the Bay Area's most interesting artists, and take home digital teaching tools that will help introduce your students to conceptual art.
This workshop and free lecture ticket is open to K-12 Educators in the Bay Area. Questions? Send an email to email@example.com.
Check out Stephanie Syjuco's latest project on KQED's Education Blog, Edspace:
Stephanie Syjuco's International Orange Commemorative Store (A Proposition)
KQED Education uses the power of KQED public media to inspire learning by providing curriculum materials, professional development, online resources and special events for educators, students, and the community at large.
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The ADE190 Artisan features a .450-inch bore plus two 4-1/2-inch one-piece hand-hammered tunable bells with a flat rim and special acoustic treatment for a pure, responsive tone. The ADE190 also features separate sets of slides for D and Eb. Mouthpiece NOT included.
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Veronica Fowler's comprehensive step-by-step manual shows you not only how to install your water garden, but maintain it entirely on your own. "Backyard Water Gardens" teaches you how to install liners, pre-formed shapes, containers and aboveground pools and fountains. From there, it helps you choose plants, add them to your garden, fertilize, prune, divide and ward off pests and diseases. But Fowler's book goes far beyond the basics, covering all the maintenance and troubleshooting of water feature hardscapes from a rip in a liner, to a damaged pool, to maintaining equipment and filters (including seasonal maintenance for winter care). Veronica Fowler's "Backyard Water Gardens" allows you to fully enjoy the convenience and versatility of water gardening, all while maintaining it with ease for years to come. "Backyard Water Gardens" is truly an all-inclusive manual, encompassing every style, type and size of water feature imaginable. No matter the "feel" you wish to convey in your garden casual, formal or whimsical Fowler's book enables you to create it with confidence. Your range of hardscape options is incredibly vast, from small, container-sized fountains that complement any space with added sound and movement, to large in-ground or aboveground ponds and streams. Larger installations not only provide soothing, rejuvenating sights and sounds; they can also house fish and plants and passively attract natural wildlife to your backyard.
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If any of the above questions interest you, you will find what you seek studying Italian at West Valley College. My name is Anthony Sargenti and I, like Virgil to Dante, will be your guide. Please feel free to email me about any questions you may have. See you in the Fall or the Spring!
A native from San Francisco, I lived in Florence, Italy from 2007-2009. From there I have traveled to many beautiful places in Italy. I studied Italian at San Jose State and abroad in Florence, where my Italian truly began to blossom. I learned the language both in the classroom as well as at the dinner table, having met two amazingly welcoming Italian families that treated me like one of their own. I like to base my courses on real world Italian and culture, using vocabulary and grammar to complement the beautiful (and often non-verbal) forms that Italians use to communicate with each other. A presto!
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text: The bedding was what I expect of a Hampton Inn, quality and comfortable. But everything else about this "hotel" screams cheap motel. The room was musty, the furnishings were old, the lobby was unimpressive, the staff seemed tired and unfriendly. This is not what I have come to expect of a Hampton Inn


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Swallowtail A photograph taken close to my house and workshop in Eftalou, depicting one of the many wonderful creatures I see ever day. Eftalou, Molyvos, Lesvos, Greece http://eric-kempson.artistwebsites.com www.epsilon-art.com
The multi-talented Eric Kempson was born in Hampshire, England in 1955, and was brought up and educated in Winchester. His early career encompassed animal keeping, working with big cats and baboons in safari parks in England and Italy, estate management, and large-scale landscape design. In 1999 he moved to Molyvos, Lesvos, Greece, with his wife and baby daughter. He now devotes himself to his painting, and to sculpture in the local olive wood:- over the years he has perfected his own techniques for working this notoriously difficult material. His influences range from Ancient Greek and Old English mythology to twentieth century Surrealism, but for his sculptures he derives his main inspiration from the grain, texture, and shape of...
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text: Sorry, Download Speeds: AT&T Added 4 Million 3G Devices Last Quarter Brian Barrett and 74 othersEditDelete Invite manuallyPromoteXDismissXUndismissBlock for gizmodoHide AT&T made over $800 million in wireless data revenue last fall, thanks to a glut of new 3G users. Unfortunately, that also puts extra strain on their already-clogged data pipes. And we've still got all that iPad traffic ahead. » 1/28/10 8:28am 1/28/10 8:28am


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Are you Aaron B Cowley?Claim your profile
Publications (13)42.12 Total impact
Article: Solution structure and properties of AlgH from P seudomonas aeruginosa: Structure of AlgH from Pseudomonas aeruginosa[Show abstract] [Hide abstract]
ABSTRACT: In Pseudomonas aeruginosa, the algH gene regulates the cellular concentrations of a number of enzymes and the production of several virulence factors, and is suggested to serve a global regulatory function. The precise mechanism by which the algH gene product, the AlgH protein, functions is unknown. The same is true for AlgH family members from other bacteria. In order to lay the groundwork for understanding the physical underpinnings of AlgH function, we examined the structure and physical properties of AlgH in solution. Under reducing conditions, results of NMR, electrophoretic mobility, and sedimentation equilibrium experiments indicate AlgH is predominantly monomeric and monodisperse in solution. Under non-reducing conditions intra- and intermolecular disulfide bonds form, the latter promoting AlgH oligomerization. The high-resolution solution structure of AlgH reveals alpha/beta-sandwich architecture fashioned from ten beta strands and seven alpha helices. Comparison with available structures of orthologues indicates conservation of overall structural topology. The region of the protein most strongly conserved structurally also shows the highest amino acid sequence conservation and, as revealed by hydrogen-deuterium exchange studies, is also the most stable. In this region, evolutionary trace analysis identifies two clusters of amino acid residues with the highest evolutionary importance relative to all other AlgH residues. These frame a partially solvent exposed shallow hydrophobic cleft, perhaps identifying a site for intermolecular interactions. The results establish a physical foundation for understanding the structure and function of AlgH and AlgH family proteins and should be of general importance for further investigations of these and related proteins. This article is protected by copyright. All rights reserved. © 2015 Wiley Periodicals, Inc.Proteins Structure Function and Bioinformatics 04/2015; 83(6). DOI:10.1002/prot.24811 · 2.92 Impact Factor
Article: Enhancing the thermal stability of mitochondrial cytochrome b(5) by introducing a structural motif characteristic of the less stable microsomal isoform[Show abstract] [Hide abstract]
ABSTRACT: Outer mitochondrial membrane cytochrome b5 (OM b5) is the most thermostable cytochrome b5 isoform presently known. Herein, we show that OM b5 thermal stability is substantially enhanced by swapping an apparently invariant motif in its heme-independent folding core with the corresponding motif characteristic of its less stable evolutionary relative, microsomal cytochrome b5 (Mc b5). The motif swap involved replacing two residues, Arg15 with His and Glu20 with Ser, thereby introducing a Glu11-His15-Ser20 H-bonding triad on the protein surface along with a His15/Trp22 pi-stacking interaction. The ferric and ferrous forms of the OM b5 R15H/E20S double mutant have thermal denaturation midpoints (Tm values) of approximately 93 degrees C and approximately 104 degrees C, respectively. A 15 degrees C increase in apoprotein Tm plays a key role in the holoprotein thermal stability enhancement, and is achieved by one of the most common natural mechanisms for stabilization of thermophilic versus mesophilic proteins: raising the unfolding free energy along the entire stability curve.Protein Engineering Design and Selection 11/2007; 20(10):511-20. DOI:10.1093/protein/gzm053 · 2.32 Impact Factor
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ABSTRACT: We report a 1.55 A X-ray crystal structure of the heme-binding domain of cytochrome b(5) from Musca domestica (house fly; HF b(5)), and compare it with previously published structures of the heme-binding domains of bovine microsomal cytochrome b(5) (bMc b(5)) and rat outer mitochondrial membrane cytochrome b(5) (rOM b(5)). The structural comparison was done in the context of amino acid sequences of all known homologues of the proteins under study. We show that insect b(5)s contain an extended hydrophobic patch at the base of the heme binding pocket, similar to the one previously shown to stabilize mammalian OM b(5)s relative to their Mc counterparts. The hydrophobic patch in insects includes a residue with a bulky hydrophobic side chain at position 71 (Met). Replacing Met71 in HF b(5) with Ser, the corresponding residue in all known mammalian Mc b(5)s, is found to substantially destabilize the holoprotein. The destabilization is a consequence of two related factors: (1) a large decrease in apoprotein stability and (2) extension of conformational disruption in the apoprotein beyond the empty heme binding pocket (core 1) and into the heme-independent folding core (core 2). Analogous changes have previously been shown to accompany replacement of Leu71 in rOM b(5) with Ser. That the stabilizing role of Met71 in HF b(5) is manifested primarily in the apo state is highlighted by the fact that its crystallographic Calpha B factor is modestly larger than that of Ser71 in bMc b(5), indicating that it slightly destabilizes local polypeptide conformation when heme is in its binding pocket. Finally, we show that the final unit of secondary structure in the cytochrome b(5) heme-binding domain, a 3(10) helix known as alpha6, differs substantially in length and packing interactions not only for different protein isoforms but also for given isoforms from different species.Proteins Structure Function and Bioinformatics 05/2007; 67(2):293-304. DOI:10.1002/prot.21250 · 2.92 Impact Factor
Article: Weak-field anions displace the histidine ligand in a synthetic heme peptide but not in N-acetylmicroperoxidase-8: Possible role of heme geometry differences[Show abstract] [Hide abstract]
ABSTRACT: We have recently reported that aquo and thioether complexes of the ferric cytochrome c heme peptide N-acetylmicroperoxidase-8 (FeIII-1) exhibit greater low-spin character than do the corresponding complexes of a synthetic, water-soluble, monohistidine-ligated heme peptide (FeIII-2; Cowley, A. B.; Lukat-Rodgers, G. S.; Rodgers, K. R.; Benson, D. R. Biochemistry 2004, 43, 1656-1666). Herein we report results of studies showing that weak-field ligands bearing a full (fluoride, chloride, hydroxide) or partial (phenoxide, thiocyanate) negative charge on the coordinating atom trigger dissociation of the axial His ligand in FeIII-2 but not in FeIII-1. We attribute the greater sensitivity of His ligation in FeIII-1 to weak-field anionic ligands than to weak-field neutral ligands to the following phenomena: (1) anionic ligands pull FeIII further from the mean plane of a porphyrin than do neutral ligands, which will have the effect of straining the His-Fe bond in FeIII-2, and (2) heme in FeIII-2 is likely to undergo a modest doming distortion following anion binding that will render the His-ligated side of the porphyrin concave, thereby increasing porphyrin/ligand steric interactions. We propose that ruffling of the heme in FeIII-1 is an important factor contributing to its ability to resist His dissociation by weak-field anions. First, ruffling should allow His to more closely approach the porphyrin than is possible in FeIII-2, thereby reducing bond strain following anion binding. Second, the ruffling deformation in FeIII-1, which is enforced by the double covalent heme-peptide linkage, will almost certainly prevent significant porphyrin doming.Inorganic Chemistry 02/2007; 46(1):48-59. DOI:10.1021/ic060682c · 4.79 Impact Factor
Article: Insight into heme protein redox potential control and functional aspects of six-coordinate ligand-sensing heme proteins from studies of synthetic heme peptides[Show abstract] [Hide abstract]
ABSTRACT: We describe detailed studies of peptide-sandwiched mesohemes PSMA and PSMW, which comprise two histidine (His)-containing peptides covalently attached to the propionate groups of iron mesoporphyrin II. Some of the energy produced by ligation of the His side chains to Fe in the PSMs is invested in inducing helical conformations in the peptides. Replacing an alanine residue in each peptide of PSMA with tryptophan (Trp) to give PSMW generates additional energy via Trp side chain-porphyrin interactions, which enhances the peptide helicity and stability of the His-ligated state. The structural change strengthened His-FeIII ligation to a greater extent than His-FeII ligation, leading to a 56-mV negative shift in the midpoint reduction potential at pH 8 (Em,8 value). This is intriguing because converting PSMA to PSMW decreased heme solvent exposure, which would normally be expected to stabilize FeII relative to FeIII. This and other results presented herein suggest that differences in stability may be at least as important as differences in porphyrin solvent exposure in governing redox potentials of heme protein variants having identical heme ligation motifs. Support for this possibility is provided by the results of studies from our laboratories comparing the microsomal and mitochondrial isoforms of mammalian cytochrome b5. Our studies of the PSMs also revealed that reduction of FeIII to FeII reversed the relative affinities of the first and second His ligands for Fe (K2III > K1III; K2II < K1II). We propose that this is a consequence of conformational mobility of the peptide components, coupled with the much greater ease with which FeII can be pulled from the mean plane of a porphyrin. An interesting consequence of this phenomenon, which we refer to as "dynamic strain", is that an exogenous ligand can compete with one of the His ligands in an FeII-PSM, a reaction accompanied by peptide helix unwinding. In this regard, the PSMs are better models of neuroglobin, CooA, and other six-coordinate ligand-sensing heme proteins than of stably bis(His)-ligated electron-transfer heme proteins such as cytochrome b5. Exclusive binding of exogenous ligands by the FeII form of PSMA led to positive shifts in its Em,8 value, which increases with increasing ligand strength. The possible relevance of this observation to the function of six-coordinate ligand-sensing heme proteins is discussed.Inorganic Chemistry 12/2006; 45(25):9985-10001. DOI:10.1021/ic052205k · 4.79 Impact Factor
Article: Enhancing the stability of microsomal cytochrome b(5): a rational approach informed by comparative studies with the outer mitochondrial membrane isoform[Show abstract] [Hide abstract]
ABSTRACT: The outer mitochondrial membrane isoform of mammalian cytochrome b5 (OM b5) is much less prone to lose heme than the microsomal isoform (Mc b5), with a conserved difference at position 71 (leucine versus serine) playing a major role. We replaced Ser71 in Mc b5 with Leu, with the prediction that it would retard heme loss by diminishing polypeptide expansion accompanying rupture of the histidine to iron bonds. The strategy was partially successful in that it slowed dissociation of heme from its less stable orientation in bMc b5 (B). Heme dissociation from orientation A was accelerated to a similar extent, however, apparently owing to increased binding pocket dynamic mobility related to steric strain. A second mutation (L32I) guided by results of previous comparative studies of Mc and OM b5s diminished the steric strain, but much greater relief was achieved by replacing heme with iron deuteroporphyrin IX (FeDPIX). Indeed, the stability of the Mc(S71L) b5 FeDPIX complex is similar to that of the FeDPIX complex of OM b5. The results suggest that maximizing heme binding pocket compactness in the apo state is a useful general strategy for increasing the stability of engineered or designed proteins.Protein Engineering Design and Selection 01/2006; 18(12):571-9. DOI:10.1093/protein/gzi067 · 2.32 Impact Factor
Article: Divergence in nonspecific hydrophobic packing interactions in the apo state, and its possible role in functional specialization of mitochondrial and microsomal cytochrome b(5)[Show abstract] [Hide abstract]
ABSTRACT: The outer mitochondrial membrane isoform of mammalian cytochrome b(5) (OM b(5)) is distinguished from the microsomal isoform (Mc b(5)) by its considerably greater stability. In contrast, OM and Mc apocytochrome b(5) (apo-b(5)) exhibit similar thermodynamic stability. Contributing substantially to the greater stability of OM b(5) relative to that of Mc b(5) is the presence of Leu at position 71. Replacing Leu-71 in OM b(5) with the corresponding Mc b(5) residue (Ser) not only diminishes holoprotein stability but also markedly compromises apoprotein stability. The studies reported herein were undertaken to clarify the role played by Leu-71 in stabilizing OM b(5)s relative to Mc b(5)s, and were motivated by the possibility that stability is related to other differences in OM and Mc b(5) properties that are important for their specialized subcellular roles. The results of these studies show that Leu-71 plays an essential role in maintaining the structural integrity of the heme-independent folding core of OM apo-b(5) (core 2), despite its location in the disordered empty heme-binding pocket (core 1). The conformational integrity of core 2 in Mc apo-b(5)s is not similarly dependent on the presence of a hydrophobic residue at position 71, providing new evidence for evolution of compensating structural features not present in OM b(5)s. We propose that Leu-71 achieves its effect on OM apo-b(5) core 2 structure by participating in a nonspecific hydrophobic collapse of disordered core 1, templated by more conformationally restricted side chains of residues in the beta-sheet that separates the two cores. We hypothesize that this has the added effect of maintaining core 1 of OM apo-b(5)s in a state more compact than that which occurs in Mc apo-b(5)s, possibly contributing to stronger heme binding by limiting the number of non-native conformations that the empty heme-binding pocket can populate.Biochemistry 12/2005; 44(44):14606-15. DOI:10.1021/bi051337m · 3.19 Impact Factor
Article: 1H, 13C and 15N NMR assignments for AlgH, a putative transcriptional regulator from Pseudomonas aeruginosa.Journal of Biomolecular NMR 10/2005; 33(1):74. DOI:10.1007/s10858-005-1271-9 · 3.31 Impact Factor
Article: Cloning, high yield overexpression, purification, and characterization of AlgH, a regulator of alginate biosynthesis in Pseudomonas aeruginosa.[Show abstract] [Hide abstract]
ABSTRACT: The most common cause of mortality among cystic fibrosis sufferers is infection by antibiotic resistant strains of Pseudomonas aeruginosa. Means to control these strains continue to be an important goal. An integral component of the ability of many of these strains to defy antibiotic therapies is the protection afforded by the mucoexopolysaccharide alginate. Production of alginate by P. aeruginosa is tightly regulated at the transcriptional level. AlgH, a putative transcriptional regulator, is involved in regulating alginate biosynthesis as well as nucleoside diphosphate kinase activity and succinyl coenzyme A synthetase activity in P. aeruginosa. Sequence homologues are found in many bacterial species. Here, we describe a method for high level overexpression and high yield/high purity production of AlgH for biophysical and functional studies. The algH gene was cloned and AlgH was overexpressed in Escherichia coli using a commercially available vector with an inducible T7 promoter. We purified the recombinantly produced protein using a rapid classical purification scheme. The yield of purified protein, either isotopically labeled for NMR studies or unlabeled, is excellent (30-37 mg of purified protein per liter of minimal media culture), as is the purity (>95% pure). Analysis of the secondary structure using circular dichroism and NMR indicates that the protein is comprised of both beta-sheet and alpha-helical secondary structural elements. Heteronuclear NMR spectra indicate that AlgH is a monodisperse, folded globular protein. This rapid, high yield, and high purity method for AlgH production will permit further biophysical characterization of this protein including high resolution structural studies.Protein Expression and Purification 09/2005; 43(1):57-64. DOI:10.1016/j.pep.2005.02.017 · 1.51 Impact Factor
Article: Stabilizing roles of residual structure in the empty heme binding pockets and unfolded states of microsomal and mitochondrial apocytochrome b 5[Show abstract] [Hide abstract]
ABSTRACT: The microsomal (Mc) and mitochondrial (OM) isoforms of mammalian cytochrome b5 are the products of different genes, which likely arose via duplication of a primordial gene and subsequent functional divergence. Despite sharing essentially identical folds, heme-polypeptide interactions are stronger in OM b5s than in Mc b5s due to the presence of two conserved patches of hydrophobic amino acid side chains in the OM heme binding pockets. This is of fundamental interest in terms of understanding heme protein structure-function relationships, because stronger heme-polypeptide interactions in OM b5s in comparison to Mc b5s may represent a key source of their more negative reduction potentials. Herein we provide evidence that interactions amongst the amino acid side chains contributing to the hydrophobic patches in rat OM (rOM) b5 persist when heme is removed, rendering the empty heme binding pocket of rOM apo-b5 more compact and less conformationally dynamic than that in bovine Mc (bMc) apo-b5. This may contribute to the stronger heme binding by OM apo-b5 by reducing the entropic penalty associated with polypeptide folding. We also show that when bMc apo-b5 unfolds it adopts a structure that is more compact and contains greater nonrandom secondary structure content than unfolded rOM apo-b5. We propose that a more robust beta-sheet in Mc apo-b5s compensates for the absence of the hydrophobic packing interactions that stabilize the heme binding pocket in OM apo-b5s.Protein Science 10/2004; 13(9):2316-29. DOI:10.1110/ps.04817704 · 2.86 Impact Factor
Article: A possible role for the covalent heme-protein linkage in cytochrome c revealed via comparison of N-acetylmicroperoxidase-8 and a synthetic, monohistidine-coordinated heme peptide[Show abstract] [Hide abstract]
ABSTRACT: N-Acetylmicroperoxidase-8 (1) contains heme and residues 14-21 of horse mitochondrial cytochrome c (cyt c). The two thioether bonds linking protein to heme in cyt c are present in 1, and the native axial ligand His-18 remains coordinated to iron. As an approach to probing structural or functional roles played by the double covalent heme-protein linkage in cyt c, we have initiated a study in which the properties of 1 are compared with those of a synthetic mono-His coordinated heme peptide containing a single covalent linkage (2). One consequence of the greater conformational restriction imposed on peptide conformation in 1 is that His-Fe(III) coordination is approximately 1.4 kcal/mol more favorable in 1 than in 2. This highlights a clear advantage conferred to cyt c by having two covalent heme-protein linkages rather than one: greater thermodynamic stability of the protein fold. EPR (11 K) and resonance Raman (298 K) studies reveal that 1 and 2 exhibit a thermal high-spin/low-spin ferric equilibrium but that low-spin character is considerably more pronounced in 1. In addition, the thioether 2-(methylthio)ethanol (MTE) coordinates 0.5 kcal/mol more strongly to 1 than to 2 in 60:40 H(2)O/CH(3)OH and only triggers the expected conversion of iron to the low-spin state characteristic of ferric cyt c in the case of 1. This demonstrates that the axial ligand field provided by an imidazole and a thioether is too weak to induce a high-spin to low-spin conversion in a ferric porphyrin. Our results suggest that a conformationally constrained double covalent heme-protein linkage, as exists in 1 and its parent protein cyt c, is an effective solution that nature has evolved to circumvent this limitation. We propose that the stronger His-Fe(III) coordination enabled by such a linkage serves to markedly enhance the effective ligand field strength of His-18. Our studies with 1 and 2 suggest that a double covalent linkage in cyt c may also enable energetically more favorable trans ligation of Met-80 than would be possible if only a single linkage were present. This would serve to further increase the stability of the protein fold and perhaps to increase the effective ligand field strength of Met-80 as well.Biochemistry 03/2004; 43(6):1656-66. DOI:10.1021/bi035531p · 3.19 Impact Factor
Article: Comparison of thioethers and sulfoxides as axial ligands for N-acetylmicroperoxidase-8: Implications for oxidation of methionine-80 in cytochrome c[Show abstract] [Hide abstract]
ABSTRACT: Methionine-80 (Met-80) in mitochondrial cytochrome c (cyt c) can be oxidized to the corresponding sulfoxide by reactive oxygen species, a reaction of potential biological significance. As an approach to investigating how oxidation of Met-80 would influence its interactions with heme iron, we have examined binding of 2-(methylthio)ethanol (MTE) and dimethyl sulfoxide (DMSO), models for the side chains of Met and Met(SO), respectively, to ferrous and ferric N-acetylmicroperoxidase-8 (AcMP8). We find that DMSO coordinates 1.2 kcal/mol less strongly to Fe(III)-AcMP8 than does MTE, although both ligands form low-spin complexes. Comparison of spectroscopic data for the DMSO complex of Fe(III)-AcMP8 with published data for the Met(SO)-80 form of ferric cyt c allows us to conclude that Met(SO)-80 does not coordinate to iron in the latter. DMSO coordinates to Fe(II)-AcMP8 1.3 kcal/mol more strongly than does MTE, whereas Met-80 and Met(SO)-80 are reported to have approximately equal affinity for Fe(II) in cyt c. This result suggests that the steric environment near the heme iron in cyt c discriminates against coordination of Met(SO)-80. Vacuum quantum chemical density functional theory calculations confirm the greater affinity of the sulfoxide and show that coordination via oxygen is strongly favored. Resonance Raman spectroscopic data indicate that the preference for coordination via oxygen is maintained in solution. The computational data further indicate that the DMSO complex derives significant enthalpic stabilization from pi back-bonding but that iron to sulfur pi back-bonding does not make a significant contribution to bonding in the thioether complex.Inorganic Chemistry 12/2003; 42(23):7550-9. DOI:10.1021/ic034689v · 4.79 Impact Factor
Article: Toward engineering the stability and hemin-binding properties of microsomal cytochromes b(5) into rat outer mitochondrial membrane cytochrome b(5): Examining the influence of residues 25 and 71[Show abstract] [Hide abstract]
ABSTRACT: As part of a larger effort to engineer the stability and hemin-binding properties of microsomal (Mc) cytochromes b(5) into rat liver outer mitochondrial membrane (OM) cytochrome (cyt) b(5), several mutants of rat OM cyt b(5) were prepared to study the effect of gradual and complete elimination of two extended hydrophobic networks, which are present in the structure of the mitochondrial protein and are absent in the structure of mammalian Mc cytochromes b(5). One of the hydrophobic networks, identified in a previous study [Altuve, A., Silchenko, S., Lee, K.-H., Kuczera, K., Terzyan, S., Zhang, X., Benson, D. R., and Rivera, M. (2001) Biochemistry 40, 9469-9483], encompasses the side chains of Ala-18, Ile-32, Leu-36, and Leu-47, whereas a second hydrophobic network, identified as part of this work, encompasses the side chains of Ile-25, Phe-58, Leu-71, and the heme. The X-ray structure of the A18S/I25L/I32L/L47R/L71S quintuple mutant of rat OM cyt b(5) demonstrates that both hydrophobic networks have been eliminated and that the corresponding structural elements of the Mc isoform have been introduced. The stability of the rat OM mutant proteins studied was found to decrease in the order wild type > I25L > A18S/I32L/L47R > L71S > A18S/I32L/L47R/L71S > 18S/I25L/I32L/L47R/L71S, indicating that the two hydrophobic networks do indeed contribute to the high stability of rat OM cyt b(5) relative to the bovine Mc isoform. Surprisingly, the quintuple mutant of rat OM cyt b(5) is less stable than bovine Mc cyt b(5), even though the former exhibits significantly slower rates of hemin release and hemin reorientation at pH 7.0. However, at pH 5.0 the bovine Mc and rat OM quintuple mutant proteins release hemin at comparable rates, suggesting that one or both of the His axial ligands in the rat OM protein are more resistant to protonation under physiological conditions. Results obtained from chemical denaturation experiments conducted with the apoproteins demonstrated that mutants containing L71S are significantly less stable than bovine Mc apocyt b(5), strongly suggesting that Leu-71 plays a pivotal role in the stabilization of rat OM apocyt b(5), presumably via hydrophobic interactions with Ile-25 and Phe-58. Because comparable interactions are absent in bovine Mc apocyt b(5), which contains Ser at position 71, it must resort to different interactions to stabilize its fold, thus highlighting yet another difference between rat OM and bovine Mc cyt b(5). During the course of these investigations we also discovered that rat OM cyt b(5) can be made to strongly favor hemin orientational isomer A (I32L) or isomer B (L71S) with a single point mutation and that release of hemin orientational isomers A and B can be kinetically resolved in certain rat OM mutants.Biochemistry 10/2002; 41(39):11566-81. DOI:10.1021/bi026005l · 3.19 Impact Factor
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SWO, Oklahoma, United States
- Department of Chemistry


text:
It appears the decision to run as an independent was a good one: Florida Gov. Charlie Crist is hanging onto the lead in his multi-way Senate race, Hotline OnCall's Reid Wilson points out.
Crist Hanging On in Florida
Since leaving the GOP, Charlie Crist has maintained a lead in his multi-way Senate race


text:
when good guys win, they are quiet about it. bad guys make a lot of noise, it makes for more interesting press.
cuz the bad guys are in charge. look up illuminatti and bilderbergs, bohemian grove, agenda 21 or 27 I forget the number
Becaause women and ******** walk all over good guys. I have the shoe prints on my back to prove it. PS. Never tell anyone I am a good guy. It'll spoil my reputation.
Amen man, that must explain why my back is always sore.
Plenty of good guys win. The bad guys just seem to get more press. The good guys are also more humble and don't seek the limelight, they just continue to do good.
Bad guys are only happy when they get what they want, good guys live by what they think is right and good things come to them.

Bad guys chase and steal, good guys wait and persevere. If your a good guy and you don't get what you want, its not because you aren't good enough or didn't get a 'fair shake', its because whatever it was you wanted wasn't good enough for you. Something better will come to you, you just have to wait and persevere.
I try to be a good guy, but even though it gets me nothing, I still try
Because the bad guys will do whatever it takes to get ahead..The good guys have limits on what they will do to get ahead...its all about morals,,
Thats what i keep asking myslef....
welcome to my world...
well it took me 22 years, but I finally won :)
Bad guys are willing to do whatever it takes . It may seem that they are benefiting,trust me it only SEEMS that way. It all works out in the Long Run.
I think that a lot of good guys do get a fair shake. Sometimes more. Some good guys give in too easily or lack ambition to keep at something until they succeed. Some good guys are so otherminded or selfless that they lose what they have or give it away.

Similarly, bad guys do not always win. The prison system is full of them. And if you look around, you'll see many other examples of people who made the wrong or "bad" choice and are paying for it.
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28-18030 - Pi Noir 5MP Raspberry Pi Night Vision Camera Module
The Raspberry Pi NOIR Camera Module is a 5 megapixel camera custom designed add-on for Raspberry Pi, featuring a fixed focus lens without an IR filter. It's capable of 2592 x 1944 pixel static images, and also supports 1080p30, 720p60 and 640x480p60/90 video. It a...
Mfr Name: Raspberry Pi
Mfr Number:
See all items in Raspberry Pi
28-18170 - Brick Pi Raspberry Pi™ Lego™ Mindstorms Adapter
Dexter Industries - Brick Pi Advanced Power Daughter Board
The BrickPi is a slide-on board that turns your Raspberry Pi into a robot. The BrickPi helps you connect LEGO® Mindstorms sensors, motors, and parts to easily turn your credit card size computer into a...
Mfr Name: Distributed By MCM
Mfr Number: BRICKPIADVANCEDPOWER
See all items in Add-On Boards and Modules
28-18035 - Trinket 3.3V Arduino Controller Module
Trinket may be small, but do not be fooled by its size! It's a tiny microcontroller board, built around the Atmel ATtiny85, a little chip with a lot of power. We wanted to design a microcontroller board that was small enough to fit into any project, and low cost e...
Mfr Name: Adafruit Industries
Mfr Number: 1500
See all items in Wearable LEDs
28-18040 - Trinket 5V Arduino Controller
Mfr Number: 1501
28-18165 - Brick Pi Raspberry Pi™ Lego™ Mindstorms Starter Kit
Dexter Industries - Brick Pi Starter Bundle
The BrickPi is a slide-on board that turns your Raspberry Pi into a robot. The BrickPi starter bundle includes everything to connect LEGO® Mindstorms sensors, motors, and parts to easily turn your credit card size c...
Mfr Number: BRICKPI-STARTER-BUND
27-2265 - 28-18 Gauge Solder Type Pins
Pin and socket sets for use with AMP "D" sub connectors. All pins and sockets are gold plated for long life. 20 per package.
Solder type pins.
Wire Gauge: 28-18
Mfr Name: Waldom Electronics
Mfr Number: 66570-3
See all items in D-Sub
28-18130 - 1200mAh 3.7V Li-Poly Battery with JST-PH cable
Lithium ion polymer (also known as 'lipo' or 'lipoly') batteries are thin, light and powerful. The output ranges from 4.2V when completely charged to 3.7V. This battery has a capacity of 1200mAh for a total of about 4.5 Wh.
The batteries come pre-attached with a ...
Mfr Number: 258
28-18080 - Flora Budget Sewable Starter Pack
Get started with the fabulous Adafruit Flora platform with this lovely budget kit, just enough to get you started with this fun wearable computer. Included are enough parts to make your first wearable electronic project. There's a Flora motherboard, four ultra-bri...
Mfr Number: 1405
28-18055 - Gemma Arduino Wearable Controller
Love FLORA but want a bite-sized version? Look no further, GEMMA is a tiny wearable platform board with a lot of might in a 1" diameter package. Powered by a Attiny85 and programmable with an Arduino IDE over USB, you'll be able to realize any wearable project!
Mfr Number: 1222
28-18050 - Flora Arduino Wearable Controller
The FLORA is small (1.75" diameter, weighing 4.4 grams). We wanted the smallest possible board for our wearable platform. In the FLORA family we also have the best stainless steel threads, sensors, GPS modules and chainable LED pixels, perfect accessories for the ...
Mfr Number: 659
28-18095 - Flora Color Sensor Module
The Adafruit Flora Color Sensor uses the best color sensor on the market, the TCS34725, which has RGB and Clear light sensing elements and a IR blocking filter. This color sensor will allow you to customize the color of your wearable LEDs to the objects around you
Mfr Number: 1356
28-18175 - Brickpi Power Pack
Dexter Industries - Brick Pi Power Supply
The BrickPi is a slide-on board that turns your Raspberry Pi into a robot. The BrickPi helps you connect LEGO® Mindstorms sensors, motors, and parts to easily turn your credit card size computer into a powerful robot.
Mfr Number: BRICKPI-POWER-PACK
28-18045 - Trinket 3V and 5V 6 Pack
Mfr Number: 1509
28-18140 - 3 X AAA Battery Holder with JST-PH Cable
This battery holder connects 3 AAA batteries together in series for powering all kinds of projects. We spec'd these out because the box is slim, and 3 AAA's add up to about 3.3-4.5V, a very similar range to Lithium Ion/polymer (Li-Ion) batteries and have an on-of...
Mfr Number: 727
28-18125 - 5V USB Li-Poly Battery Charger
This is a tiny LiPo charger, so handy you can keep it any project box! Its also easy to use. Simply plug in the gold plated contacts into any USB port and a 3.7V/4.2V lithium polymer or lithium ion rechargeable battery into the JST plug on the other end. There are...
Mfr Number: 1304
MCM Electronics gave me terrific service and great prices. I will cheerfully shop with them again for my electronic needs.


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I'am using JSTL for jsp pages to display data. This is my code.
<c:set var ="input1" value="${event.eventData}"/>
<c:out value=" <%= stringCustomizer.stringTokernize(args1,0,10) %>" />
first argument(args1) of
stringTokernize() method is, "input1" variable which I initialize above. How can I give that variable inside the
<%=%> tag?
I tried couple of ways, but still getting invalid syntax.
stringCustomizer is a java class for customize my input string. In front end, I use that into customize my display data


text:
Amid corporate intrigue and overwrought shows, Louis Vuitton, Valentino, and Miu Miu deliver subtle delights.
But its legislative reaction is overwrought, and bordering on the fascist.
By now I'm so overwrought with chi's and fu's and kong's and kung's that my eyes have about crossed.
"work beyond a person's strength," 1819; see overwork (v.). Old English oferweorc meant "a superstructure, sarcophagus, tomb."


text:
2000 Honda Civic Q&A
2000 Honda Civic Question: Radio code
radio is locked need to unlock , radio shows CODE E - help me. - kiranjakkaraju
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How to entering radio codes for Honda Civic 2002 after replacing batteries; while there is nothing appear on the radio sc...
kindly provide me with the car stereo code number
i disconnected the battery and now the radio says to enter a code,where do i find out what the code is
Naturally I disconnected the battery cables and now the radio/cd player does not work....What are the step-by-steps to load the code... Thanks-A-Million
I need to find out the code to my car radio after I change the battery to unlock it.
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text:
17 Easy Recipes for a Slow Cooker
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Only the most delicious slow cooker appetizer recipes have been added to this growing selection. Check out these easy slow cooker appetizers for any occasion.
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Written on: 20/07/2011 by JoGallagher (3 reviews written)
yes the food has to be paid for and is limited, and there's the rip-off queue jumping premium (which everyone buys now so it's pointless), but aside from that I'd say Easyjet are pretty good actually,
You get what you pay for: budget air travel. But they're at least friendly and look like they want to be there. Most other budget airlines make you feel like they're doing you a favour!
cheap flights, efficient service, minimum fuss. does what it says on the tin so i'm not unhappy.


text:
Game Stats
Game Stats
W: C. Qualls (6-4) L: J. Isringhausen (1-2)
S: B. Lidge (40)
|3rd Inning
Edmonds hit sacrifice fly to left, Carpenter scored.
|4th Inning
Lane singled to shallow center, Ensberg scored, Berkman to second.
|4th Inning
Reggie Sanders (19) solo shot to right off Backe.
|5th Inning
Lance Berkman (22) 2 run shot to right off Carpenter, Ensberg scored.
Mike Lamb (11) solo shot to right off Carpenter.
|5th Inning
Edmonds singled to right, Carpenter scored, Eckstein to second.
Walker hit sacrifice fly to center, Eckstein scored.
Reggie Sanders (20) 2 run shot to left off Strickland, Pujols scored.
|6th Inning
Biggio hit sacrifice fly to center, Ausmus scored.
Taveras singled to center, Scott scored.
|9th Inning
Ensberg doubled to left, Taveras scored.


text:
Movie mogul Harvey Weinstein is already preparing a sequel to Quentin Tarantino's forthcoming war movie INGLOURIOUS BASTERDS, despite branding lead actor Brad Pitt's work "the worst performance of his life".
Weinstein, one of the film's executive producers, wasn't impressed by Pitt's portrayal of an American lieutenant who leads a team of Jewish soldiers in World War II.
And he insists the film is so odd and difficult to categorise that fans will either love or hate it.
In a bizarre rant with GQ magazine, Weinstein says, "It isn't funny; it isn't exciting; it isn't a realistic war movie, yet neither is it an entertaining genre spoof or a clever counterfactual wartime yarn. It isn't emotionally involving or deliciously ironic or a brilliant tissue of trash-pop references. Nothing like that.
"Brad Pitt gives the worst performance of his life, with a permanent smirk as if he's had the left side of his jaw injected with cement, and which he must uncomfortably maintain for long scenes on camera without dialogue."
But the film's cast and Weinstein himself are so excited about the film's release, the producer is already putting together plans for its sequel: "Brad wants to do Inglourious II. We all want to do it. And the movie hasn't even come out yet."


text:
Former Indianapolis Colts head football coach and NFL analyst Tony Dungy will make an upcoming visit to the campus of East Central Community College at an event promoting the school's football program. According to a news release, ECCC Warriors first-year head coach Ken Karcher is a longtime friend and associate of Dungy. Dungy retired from coaching in 2008. He achieved ...Read More »
Tag Archives: NFL
Alyne Payton dies
Alyne Payton, mother of the late, great Jackson State and Chicago Bears running back Walter Payton has died, Mississippi Sports Hall of Fame director Rick Cleveland reported today. Cleveland writes: Mrs. Payton endured the early deaths of husband to an aneurysm in 1978 and Walter (to liver disease) in 1999. Through it all, she carried herself with grace and dignity. ...Read More »
Legendary NFL broadcaster Pat Summerall dies
DALLAS (AP) — Pat Summerall, the deep-voiced NFL player-turned-broadcaster who spent half of his four decades calling sports famously paired with John Madden, died Tuesday. He was 82. Susie Wiles, Summerall's daughter, said her father died in Dallas. "He was an extraordinary man and a wonderful father," Wiles said. "I know he will be greatly missed." Summerall was part of ...Read More »
February 8, 2013- Ricky Nobile
Wireless carriers plan for Super Bowl Sunday
A dropped call from your smartphone can leave you with a sinking feeling equivalent to witnessing a dropped pass by your favorite NFL receiver: shock, disbelief and maybe some frustration and anger mixed in for good measure. Whether its a dropped call, a text fail or a buffering browser, two of the country's leading wireless carriers are making sure its ...Read More »
Tagliabue overturns Goodell on Saints suspensions
NEW ORLEANS — In a sharp rebuke to his successor's handling of the NFL's bounty investigation, former Commissioner Paul Tagliabue overturned the suspensions of four current and former New Orleans Saints players in a case that has preoccupied the league for almost a year. Tagliabue, who was appointed by Commissioner Roger Goodell to handle the appeals, still found that three ...Read More »
October 15, 2012- Ricky Nobile
July 23, 2012- Ricky Nobile
Bounty Consequences: Saint's Peyton gets 1-year suspension, team loses 2nd round pick
The NFL has suspended New Orleans Saints head coach Sean Payton for one year for his involvement in a forbidden "bounty" program, ESPN's Adam Schefter reported on Wednesday. According to Schefter, Saints general manager Mickey Loomis will be suspended for eight games and fined $500,000. The team will also be fined $500,000 and will lose a second round pick in ...Read More »


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Lee LeFever: An interview by Bob Morris
Lee LeFever is the founder of Common Craft and author of The Art of Explanation– Making Your Ideas, Products and Services Easier to Understand. In 2007 he saw an opportunity to explain technology using short animated videos. Starting with the video RSS in Plain English, he and Common Craft produced a series of videos and created a visual style that has inspired communicators around the world. Today, videos that use paper cut-outs and a whiteboard are known as "Common Craft Style" and are often made by students as classroom projects.
Since 2007 his company has worked with the world's most respected brands, inspired the explainer video industry and earned over 50 million online views. The video Common Craft produced with Dropbox.com has resided on the company's home page for over three years and generated 30 million views.
Today his focus is helping others become better explainers through the book and Common Craft Membership, which offers ready-made videos, cut-outs and know-how. He lives in Seattle, WA with his wife and business partner Sachi and their dog Bosco, a fine swimmer.
Here is an excerpt from my interview of him. To read the complete interview, please click here.
* * *
Morris: Before discussing The Art of Explanation, a few general questions. First, who has had the greatest influence on your personal growth? How so?
LeFever: This is very clear to me. It is my wife, Sachi. She is a constant source of motivation and perspective. She has taught me the meaning of excellence and helped me see small ways I can improve every day. We mold and teach each other in every part of our lives.
Morris: Years ago, was there a turning point (if not an epiphany) that set you on the career course you continue to follow? Please explain.
LeFever: Yes, I can remember a specific instance when I saw the problem that I would spend years trying to solve. I was at a small conference in Silicon Valley in 2004 and a tech CEO was speaking to a group of 50 people. The CEO mentioned RSS, the technology that makes it easy to subscribe to a website. When a gentleman asked "What is RSS?" the CEO replied with an answer I'll never forget: "It's an XML-based content syndication format." His answer was technically correct and mostly incomprehensible. It was at this point that I saw the explanation problem for the first time. The big thing limiting the adoption of RSS was not necessarily design, price or availability, but explanation. The technologists were doing the explaining and doing it poorly. I thought I could do better.
Morris: What do you know now about the business world that you wish you knew when you when to work full-time for the first time? Why?
LeFever: There's a quote I've heard that I think about sometimes. It goes something like "Don't spend your time working on someone else's dreams – go work on your own."
Morris: The greatest leaders throughout history (with rare exception) were great storytellers. What do you make of that?
LeFever: I accept it as truth, but I have a twist on it. Storytelling is a general term that has broad meaning and value. But stories do not, by default, solve problems or make things easy to understand. I think great leaders are often great explainers who use storytelling as one means of making their communication more interesting and understandable.
Morris: In recent years, there has been criticism, sometimes severe criticism of M.B.A. programs, even those offered by the most prestigious business schools. In your opinion, in which area is there the great need for immediate improvement? Any suggestions?
LeFever: Communication. From my perspective, there is a single thread that runs through nearly every part of professional life – the ability to communicate clearly. Without it, one can accomplish very little.
* * *
To read the complete interview, please click here.
Lee cordially invites you to check out the resources at these websites:
Watch Common Craft videos here.
Find The Art of Explanation at its Amazon page here.
Lee's personal website is here.
Michael Lewis on Sheryl Sanberg's "Manifesto"
The most powerful working mother in Silicon Valley, Sheryl Sandberg may wish her life weren't viewed as a social statement. But since it is, the C.O.O. of Facebook is tackling the issue head-on. In the April 2013 issue of Vanity Fair, Michael Lewis checks out Sandberg's manifesto.
Portrait by Annie Leibovitz
To check out The Rise of Women in Silicon Valley, a collection of Jonas Fredwall Karlsson photographs some of the most powerful women in Silicon Valley, please click here.
* * *
Sheryl Sandberg is one of those people who attract more attention than they want. If she were a man, no one would think twice about her career: McKinsey consultant, chief of staff to U.S. Treasury secretary Larry Summers, head of one of Google's biggest businesses, and now chief operating officer of Facebook. Those are the sorts of jobs that people who finish at the top of their Harvard Business School class wind up in. Alas, Sheryl Sandberg is not a man, and so her career is not just a bunch of jobs she happens to have held but a social statement.
Sandberg claims she never really wanted to write a book, that her subject was thrust upon her by the way her own career has been viewed. I believe her. Lean In: Women, Work, and the Will to Lead is a heavily researched manifesto aimed at a single question: Why are so few positions of economic and political power held by women? "The blunt truth is that men still run the world," Sandberg writes. Just 19 out of all the C.E.O.'s in the Fortune 500 are women. The United States has a female majority, yet its Congress remains 82 percent male. In the most intense arenas of American ambition the situation for women is even worse. There are plenty of women on Wall Street, for instance, but the big firms and the financial risktaking are still dominated by men. (And look how that's worked out!) In Silicon Valley the woman who gets to power is regarded as a cyborg. If she gets pregnant, it's genuinely newsworthy.
Obviously, there are all sorts of reasons for the inequity at the top of American life, and Sandberg addresses most of them. But she takes a particular interest in the ways women undermine their own cause. Women tend more than men to view their success as fraudulent, for instance. They give in too quickly to the idea that you can't have both a career and a family; they fail to take risks they need to take; they are afraid to demand that their husbands do their fair share of the housework; they misunderstand how to cultivate useful relationships with their superiors. After a female subordinate describes to Sandberg what she imagines a corporate mentor to be, Sandberg tells her, "That's not a mentor. That's a therapist."
Some women will be annoyed by Sandberg's challenge, but I'll bet most will be thrilled by it. And I suspect at least a few men will read this book and think, Oh no, they're starting to catch on.
Lean In: Facebook's Sheryl Sandberg Explains What's Holding Women Back
Here is a brief excerpt from an article by the National Public Radio staff in which they discuss Sheryl Sanberg and her bestseller, Lean In: Women, Work, and the Will to Lead, published by Knopf Doubleday Publishing Group (March 11, 2013). To read the complete article, check out other resources, and learn more about NPR, please click here.
* * *
Of all the posters plastered around Facebook's Silicon Valley headquarters — "Move Fast and Break Things," "Done Is Better Than Perfect" and "Fail Harder" — Chief Operating Officer Sheryl Sandberg has a favorite: "What Would You Do If You Weren't Afraid?"
"[It's] something that I think is really important and I think very motivating," Sandberg tells NPR's Renee Montagne. " … I wrote in my book, what I would do if I wasn't afraid is, I would speak out more on behalf of women."
That book — Lean In: Women, Work, and the Will to Lead — is something of a feminist call to arms. In it, Sandberg, a 43-year-old former Google executive with two Harvard degrees, is calling on other women, as she puts it, to "lean in" and embrace success. And it has struck a chord. In the weeks leading up to the book's publication on Monday, Sandberg, who has not been known to court controversy in the past, has been the subject of critical op-eds and cranky commentaries.
Sandberg is no stranger to success. Back in 2011, she was named Forbes Magazine's fifth most powerful woman in the world (after No. 1 German Chancellor Angela Merkel, No. 2 Hillary Clinton, No. 3 President of Brazil Dilma Rousseff and No. 4 CEO of PepsiCo Indira Nooyi).
"I thought it was absurd," says Sandberg. "My mother even called to say, 'Well, dear, I do think you're very powerful, but I'm not sure you're more powerful than Michelle Obama,' and I'm thinking, 'Of course I'm not more powerful than Michelle Obama!' " (Obama was No. 8, having dropped from the No. 1 spot in 2010.)
"I was really embarrassed," Sandberg says. "People would congratulate me in the halls at Facebook, and I would literally tell them why it was silly. People would post it on Facebook, and I would call them and ask them to, you know, 'Can you take that off? I really don't feel comfortable.'
"My assistant pulled me into my conference room and closed the door. And she said, 'You're handling this really badly. Stop telling everyone who says congratulations how silly that list is, because you look insecure. You're showing everyone how uncomfortable you are with your own power, and that's not good, so just start saying thank you.' "
Two lines of argument run through Lean In. One of them has to do with how society has changed through multiple generations of feminism. The other has to do with the way society views women — and how that affects the way women view themselves.
* * *
To read the complete article, please click here.
Joey Reiman: Part 2 of an interview by Bob Morris
Joey Reiman is CEO and founder of BrightHouse. Over the past 25 years, Joey has worked with leadership at The Coca-Cola Company, Procter & Gamble, McDonald's and Newell Rubbermaid, and has emerged as one of the nation's foremost visionaries and leading authorities on thinking and marketing. He is the best-selling author of several books, including Thinking for a Living and, more recently, The Story of Purpose: The Path to Creating a Brighter Brand, a Greater Company, and a Lasting Legacy. He is also a world-renowned speaker who provides listeners with the inspiration and foresight needed to become leaders of the future.
A graduate of Brandeis University, Joey has won more than 500 creative awards in national and international competitions, including the Cannes Film Festival. He also teaches a course on "Ideation" as an adjunct professor of the Goizueta Business School at Emory University. Joey is a librettist, author, soul man, professor, iconoclast, screenwriter, speaker, and jump roper. He is a father, husband and Famillionaire who lives in Atlanta with his wife and two sons.
Here is an excerpt from Part 2 of my interview of him.
To read all of it, please click here.
To read Part 1, please click here.
* * *
Morris: When and why did you decide to write Thinking for a Living?
Reiman: The world was ad rich and idea poor. I was making some if the best ads on the planet, winning hundreds of awards and having a great time. But something was wrong. I was getting paid to execute my ideas rather than come up with them. The advertising model was always based on media spend. Then the creative was thrown in free. What kind if model is that? I thought, what if I were to be paid for raw but vital ideas. Ideas that as Steve Jobs would later say, "put a dent in the universe." and what if I sold these idea to visionaries rather than ad directors? I shuttered my multi-million dollar ad agency and built a consultancy with nine of the nest thinkers on the planet. Thinking For A Living tells this story and lays down the tenants of great thinking.
Morris: Were there any head-snapping revelations while writing it? Please explain.
Reiman: Yes, that what I was writing about was truly revolutionary. I remember sitting with the head if one of the largest agency group on earth. After I told him about this idea I had called "ideation" he looked at me as if my cheese had fallen off the cracker. He feels very differently about me today as many of his biggest clients seek BrightHouse counsel.
Morris: To what extent (if any) does the book in final form differ significantly from what you originally envisioned?
Reiman: Writing a book allows you to write new chapters in your own life. While writing Thinking For A Living, I realized that some ideas were indeed bigger than others–the largest being purpose. That insight would set my course and career for the next eighteen years.
Morris: I commend you on your skill with regard to formulation of chapter titles. They evoke questions that alert readers to your key points. For example, how did the most money you "never made" teach how to think for a living? (Chapter 1)
Reiman: In advertising, you win business by presenting great ideas but you are only paid when you execute them. The most money I never made was about winning the Days Inn business with a big idea. Though I won the business, the hotel's leadership wanted a different agency than mine. They asked if they could buy the idea for a lot of money. But my ego got the best of me and I said no. They acquiesced and I got the account. A year later my CFO told me that we had made about 100k on the account. If I had let them pay just for the idea, my agency would have made a fortune. From that day forward I would have no reservations about a hefty idea fee from another hotel company.
Morris: Here's another: How did the "scariest experience" of your life teach you "thinking is about a lot more than thought"? (Chapter5)
Reiman: As I lay in a hospital room in Rome, I learned about the power of ideas—that thought had wings. My thinking would lead to my first book SUCCESS.THE ORIGINAL HANDBOOK. In this work, I shared my journey to recovery with 5 tenants that correlated with your five fingers. Br THUMBS up. POINT at to your purpose. Give your MIDDLE FINGER to fear. March FORTH and LITTLE things mean a lot.
Morris: And another: How best to create a "thinking company"? (Chapter 7)
Reiman: Here I outline what it takes to build a more thoughtful company. They say that money talks. But people think. And that's your real asset. I think the term "human resources" is an obscenity. People are not resources to be used up. We should rename our HR function: HUMAN RESOURCEFULNES
Morris: I agree wholeheartedly with you about "the centrality of creative ideas in modern life and how to nurture and foster and create ones that will revitalize" one's business, family, and being, "and in the most profound way, our whole society." To what extent is your book a "road map" for that proces
Reiman: THINKING FOR A LIVING is more a compass. The roadmap would come in my next book, THE STORY OF PURPOSE.
Morris: With all does respect to Archimedes, I agree with Isaac Asimov: "The most exciting phrase to hear in science, the one that heralds new discoveries, is not 'Eureka!' (I found it!) but 'That's funny…'" Your own thoughts about all this?
Reiman: With all due respect to Issac Asimov, I believe in celebration of thought. Yes, all eurekas are preceded with a 'that's funny" but the elation I feel occurs when I find that the missing thought is so overwhelming that I have to walk away from what I have just discovered.
Morris: You devote Chapter 2 to a discussion of what your characterize as "The Golden Age of Ideas." When was it and what are its defining characteristics?
Reiman: Machines ran the Industrial Age. The industrious Age of Ideas will be run by our minds.
Morris: However different great thinkers throughout history may be in most respects, they do share certain characteristics in common. You suggest nine. Which of them can almost anyone acquire or develop? Please explain.
Reiman: BIG THINKERS ARE ON FIRE: Find your purpose and you will ignite your passion. Once lit, fan it and your ideas will catch fire. BIG THINKERS NEVER LOSE IN THEIR IMAGINATION: Worry is a form of atheism. Use your faith. BIG THINKERS BET THE FARM: Creativity is the destination but courage is the journey. What's the worst that can happen if you take a risk? Whatever your answer, its no where near as bad as not taking the risk. BIG THINKERS MARINATE IN THOUGHT: Wonder? Leads to Wonder! Remember in grammar school when you got the points for how you got to the answer rather than the answer. Life till works that way. BIG THINKERS THINK BETTER TOGETHER: No one has ever done something great alone. You need two people in your life—a soul mate for life and a goal mate for business. BIG THINKERS DON'T TAKE NO FOR AN ANSWER: Meet every no with a yes. It's a bigger word. BIG THINKERS TURN REALITY INTO FANTASY. Imagine the way the world ought to be. Now move there. BIG THINKERS LIVE THEIR LIVES ON PURPOSE. If you have a why, you can deal with any what, who, where or when. BIG THINKERS THINK WITH THEIR HEART: the brain runs everything but the heart runs the brain.
Morris: In your opinion, what has been the single most significant change in workplace culture since Thinking for a Living was first published in 1998? Please explain.
Reiman: Respect for ideas and the people who have them.
Morris: In your opinion, what will be the single most significant change during (let's say) the next 3-5 years? Please explain.
Reiman: Today's currency is the idea but tomorrow's ideas will be the currency.
Morris: When and why did you decide to write The Story of Purpose?
Reiman: I wrote THE STORY OF PURPOSE so that people would never have to work again. Instead of getting a job they could heed their calling. If enough people did this the world would be a lot happier.
Morris: In the Introduction, Phil Kotler refers to "the societal benefit that organizations are capable of delivering when they believe they have a greater responsibility in the world." For example?
Reiman: When Sony founder, Akio Morita was presented a strategy for his fledgling company, it read "to be the best technology company in Japan." He changed it to "Japan being the best technology country in the world." If you want to find your purpose, look beyond yourself.
Morris: Please explain your reference, in the Preface, to "the most exciting time and place in business
Reiman: For the first time in history, business is part of every human endeavor. As the largest sector on the planet business has a responsibility to protect and nurture those living on it.
Morris: In September of 1978, after Israel's Prime Minister Menachem Begin and Egypt's President Anwar Sadat agreed to several accords during meetings at Camp David, they were asked to explain why they were able to reach those agreements, given the fact that their respective countries had been bitter and bloody enemies for thousands 0f years. Prime Minister Begin replied, "We did what all wise men do. We began at the end." In my opinion, Prime Minister Begin offers excellent advice to leaders of organizations that need to become purpose-driven. Do you agree?
Reiman: Prime Minister Begin is correct in that to begin in the end is to return to the beginning—both are states of peace. As I like to say, "the fruits are in the roots."
Morris: Throughout history, organizations (what6ever their size and nature may be) have been "purpose-driven." For example, to become the largest, most profitable, and dominant in their competitive marketplace, etc. In your opinion, are these self-serving purposes and social responsibility mutually exclusive or, in fact, [begin italics] interdependent [end italics]? Please explain.
Reiman: Bigger is better. Google, Apple, Whole Foods and GE are all big companies with purpose whose leaders also believe that better is bigger.
* * *
To read all of Part 2, please click here.
To read Part 1, please click here.
Joey invites you to check out the resources at these websites:
Joey's website
BrightHouse homepage
Amazon page
Goizueta faculty page
LinkedIn page
Joey Reiman: Part 1 of an interview by Bob Morris
Joey Reiman is CEO and founder of BrightHouse. Over the past 25 years, Joey has worked with leadership at The Coca-Cola Company, Procter & Gamble, McDonald's and Newell Rubbermaid, and has emerged as one of the nation's foremost visionaries and leading authorities on thinking and marketing. He is the best-selling author of several books, including Thinking for a Living and, more recently, The Story of Purpose: The Path to Creating a Brighter Brand, a Greater Company, and a Lasting Legacy. He is also a world-renowned speaker who provides listeners with the inspiration and foresight needed to become leaders of the future.
A graduate of Brandeis University, Joey has won more than 500 creative awards in national and international competitions, including the Cannes Film Festival. He also teaches a course on "Ideation" as an adjunct professor of the Goizueta Business School at Emory University. Joey is a librettist, author, soul man, professor, iconoclast, screenwriter, speaker, and jump roper. He is a father, husband and Famillionaire who lives in Atlanta with his wife and two sons.
Here is an excerpt from Part 1 of my interview of him. To read the complete interview, please click here.
* * *
Morris: Before discussing Thinking for a Living and then The Story of Purpose (in Part 2), a few general questions. First, who has had the greatest influence on your personal growth? How so?
Reiman: St. Jude. He is the catholic Saint of the impossible. While in Rome, I was a passenger in a car accident where I was paralyzed. In the hospital, I was inspired by his spirit and recovered 100%. From that moment forward, I would know that nothing is impossible. As movie mogul Samuel Goldwyn once wrote, " I'm possible."
Morris: The greatest impact on your professional development? How so?
Reiman: The advertising legend, Al Hampel, who made me at 29, the youngest EVP of a billion dollar ad firm. My first big job was to build the Atlanta, Georgia office. I was to spend a year building it up. That was nearly 30 years ago.
Morris: Years ago, was there a turning point (if not an epiphany) that set you on the career course you continue to follow? Please explain.
Reiman: Yes in 1994, I realized that any gifts I had were being squandered in advertising selling stuff to people. It was easy because people can't get enough of what they don't need. I leveled my 200 million dollar ad firm and built BrightHouse, the world's first ideation consultancy. Our purpose was to think for a living.
Morris: To what extent has your formal education been invaluable to what you have accomplished in life thus far?
Reiman: Brandeis University taught me t think large and to be the best Joey I could be, not someone else.
Morris: What do you know now about the business world that you wish you knew when you when to work full-time for the first time? Why?
Reiman: That if we are not in business to improve life, we have no business being in business. Too many organizations are focused on the life of the business versus the business of life.
Morris: Of all the films that you have seen, which – in your opinion – best dramatizes important business principles? Please explain.
Reiman: The best is The King's Speech as it teaches consultants that they must lead even if their clients are Kings. If you tell your client only what he wants to hear you are not the King's counselor but a jester.
Morris: From which [begin italics] non- [end italics] business book have you learned the most valuable lessons about business? Please explain.
Reiman: The Hero's Journey by Joseph Campbell as it is [begin italics] the story [end] of every company and leader on a quest to bring a boon to society.
Morris: Here are several of my favorite quotations to which I ask you to respond. First, from Lao-Tzu's Tao Te Ching:
"Learn from the people
Plan with the people
Begin with what they have
Build on what they know
Of the best leaders
When the task is accomplished
The people will remark
We have done it ourselves."
Reiman: If all teachers took this as an oath, our civilization would be far ahead of where we are today. Modern education pushes aspirations into our heads rather than pull our dreams out from our hearts.
Morris: Next, from Voltaire: "Cherish those who seek the truth but beware of those who find it."
Reiman: Finding the truth is no less miraculous than discovering the Holy Grail. Though the prize is elusive, the gifts we find along the way are immeasurable. I searched for truth in advertising and could not find it but my journey took me down a path of questioning the basic tenants of business.
Morris: And then, from Oscar Wilde: "Be yourself. Everyone else is taken."
Reiman: And then from Mark Twain, " the two best days are the day you were born and the day you find out why."
Morris: From Albert Einstein: "We cannot solve our problems with the same thinking we used when we created them."
Reiman: BrightHouse enlists over 300 luminaries–subject matter experts– outside the arena of business to solve the problems of business.
Morris: Finally, from Peter Drucker: "There is surely nothing quite so useless as doing with great efficiency what should not be done at all."
Reiman: Many business people are classically trained for a world that does not exist. It is not enough to be precise, we must also be passionate. Passionate efficiency is an oxymoron.
Morris: In Tom Davenport's latest book, Judgment Calls, he and co-author Brooke Manville offer "an antidote for the Great Man theory of decision making and organizational performance": organizational judgment. That is, "the collective capacity to make good calls and wise moves when the need for them exceeds the scope of any single leader's direct control." What do you think?
Reiman: Business needs to be capable of more responsible action than it has collectively achieved to date.
Morris: Here's a brief excerpt from Paul Schoemaker's latest book, Brilliant Mistakes: "The key question companies need to address is not 'Should we make mistakes?' but rather 'Which mistakes should we make in order to test our deeply held assumptions?'" Your response?
Reiman: There are mistakes made because we have not learned to avoid them and then there are mistakes made avoiding them. The former gets us fired. The latter gets us fired up
Morris: In your opinion, why do so many C-level executives seem to have such a difficult time delegating work to others?
Reiman: Too many C-Suite leaders are alpha-male, steely-eyed, autocratic-know-it-alls who have been taught leadership means control. Just the opposite. Purposeful leadership is about guardrails for associates to experiment within rather than guidelines to follow as rules.
Morris: The greatest leaders throughout history (with rare exception) were great storytellers. What do you make of that?
Reiman: Human beings are meaning seeking creatures which is what why story tellers Moses, Jesus and Buddha emerged as the world best storytellers. Our greatest American President was also Washington's best story teller-Abraham Lincoln. Every business leader today needs a "once upon a time" if they hope for a "happily ever after."
Morris: Most change initiatives either fail or fall far short of original (perhaps unrealistic) expectations. More often than not, resistance is cultural in nature, the result of what James O'Toole so aptly characterizes as "the ideology of comfort and the tyranny of custom."
* * *
To read the complete interview, please click here.
Joey invites you to check out the resources at these websites:
Joey's website
BrightHouse home page
Joey's Amazon page
Goizueta faculty page
LinkedIn page
"The Top 100 Speeches" throughout United States history
If you click here you can check out "The Top 100 Speeches" at the American Rhetoric website.
Better yet, you can click on any/all of the 100 speeches and read the text.
And even better yet, you can click on any/all of them and download a pdf for your own personal media library.
Here are the "Top 10″:
1, Martin Luther King, Jr., "I Have A Dream"
2. John Fitzgerald Kennedy, Inaugural Address
3. Franklin Delano Roosevelt, First Inaugural Address
4. Franklin Delano Roosevelt, Pearl Harbor Address to the Nation
5. Barbara Charline Jordan, 1976 DNC Keynote Address
6. Richard Milhous Nixon, "Checkers"
7. Malcolm X, "The Ballot or the Bullet"
8. Ronald Wilson Reagan, Shuttle "Challenger" Disaster Address
9. John Fitzgerald Kennedy, Houston Ministerial Association Speech
10. Lyndon Baines Johnson, "We Shall Overcome"
I haven't as yet checked out all of them but already know that most of these ten and the other 90 can also be seen on film. Thank you Google!
While on the subject of great speeches, I also high recommend William Safire's Lend Me Your Ears: Great Speeches in History, Updated and Expanded Edition. Amazon now sells a hardbound edition for only $29.70, a 34% discount. For anyone who has a keen interest in great speeches, this would be an outstanding holiday gift. Just a thought….