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Check out this great sample class from the IDEA Article Archive on using medicine balls to teach control and awareness! As an IDEA member, all of the sample classes in our archive are free to you!!
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Music video for the song -forever and ever- by HACO, from the album by the same name, released 2011.
Lost and found Super-8 images, shot in another lifetime.
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Mentor Senior Center 440.974.5725 or 440.255.1100, ext. 2470, www.cityofmentor.com/play/seniors Casino Tours *All incentives and itineraries are subject to change without notice. All passengers must be 21 yrs of age. Everyone must have proper identification at the time of departure. The Meadows Racetrack & Slots Meadow Lands, PA International, MARIETTA Monday, February 8 Historic and Ethnic PADDLEWHEEL TOUR Put 'N Bay 8:00 a.m. – 8:00 p.m. Wednesday, May 26 Tuesday, July 20 This brand new facility opened in June 2009. It features over 3700 slots and 7 restaurants. It has a Atlantic City Cleveland, Part II Friday, March 19 7:00 a.m. – 8:30 p.m. Enjoy the beautiful modern-day 7:30 a.m. – 6:00 p.m. Wednesday, June 23 – 8:30 a.m. – 5:00 p.m. We will board the Jet Express and head bowling alley and simulcasting of races. Incentives sternwheeler, the Valley Gem with are $20 slot play. No refunds after February 1. Friday, June 25 Back by popular demand, John to Put n Bay Island. You will have plenty Spectacular views of the scenery in this Cost $29 Latkovich of JKL Tours will lead us on a of time on your own to shop and enjoy the charming Ohio river town. Lunch will be unique tour that combines history, food scenery. You can rent a golf cart or take This is a 2 nights, 3 day trip. We will stay at Claridge at one of the last riverboat-era hotels. We and culture to give you a view of the a tour of the island by bus. Lunch will be Seneca Niagara Casino Towers (part of Bally's) in Atlantic City which is located right on heritage that makes Cleveland unique. will visit Fenton Art Glass to see timeless works of art and we'll also visit Rossi on your own in one of the wonderful the strip. Enjoy a stroll on the boardwalk and enjoy the many Tour highlights include League Park, restaurants on the island. No refunds after Niagara Falls, NY Pasta. No refunds after April 12. shops in the area. Casino incentive is $20 slot play and 2 where Babe Ruth hit his 500th homerun, July 6. Cost $48 Saturday, August 21 breakfasts. Tremont, Coventry-on-the-Heights, Cost $62 7:00 a.m. – 9:00 p.m. Over 3700 slot machines along with table games. $200pp/ Double Occupancy, $185pp/ Triple Occupancy, Steelyard Commons, Slavic Village and a delightful lunch at an authentic Hungarian Malabar Farm Covered Bridges of The casino is within walking distance to the falls. Thursday, June 3 $294pp/Single Occupancy, $170pp/ Quad Occupancy restaurant. No refunds after February 12. Casino incentives of $20 slot play and $5 food. No refund after August 13. No refund is guaranteed after May 14 unless your reservation is resold. Cost $59 7:30 a.m. – 8:00 p.m. Ashtabula County Cost $33 Tour one of the most historic movie Wednesday, September 1 Payment in full will secure your reservation and reservations are taken palaces, the Renaissance Theatre where 9:00 a.m. – 5:30 p.m. Seneca Alleghany on a first come, first serve basis. Brown Bag Tour the sounds of the mighty Wurlitzer will A local guide will highlight several of serenade you. Visit the wedding site of Casino Salamanca, NY Soaring Eagle Casino Tuesday, April 13 7:00 a.m. – 6:30 p.m. Bogey and Bacall and dine in an 1820's stage coach stop at Malabar Farm the Ashtabula county covered bridges. We will also enjoy wine-tasting at a local We will tour Wendell August Forge, Restaurant. The Historic Carousel District winery, lunch and the Ashtabula Marine Thursday, April 8 Tuesday, September 14 – Volant Winery, Slovak Folk Craft Shop, has stores ranging from jelly beans to Museum. No refunds after August 2. 8:00 a.m. – 8:00 p.m. Casino has slot machines and table games and for Thursday, September16 the Cheese House and the town of antiques. Bring back a homemade Bundt Cost $57 Volant. At each stop passengers get a gift cake from the Eatmor Bundt Company. those interested they also have a place to play for the brown bag. Lunch is included at Take a ride on the whimsical wooden bingo. Casino incentives of $20 slot play and $5 This Casino is one of the biggest in the area with over 3700 slot Neshanock Inn. No refunds after carrousel or step into the past at the food. No refund after April 1. Cost $29 machines plus table games. Wednesday you can play Bingo. Enjoy March 12. Cost $72 Olivesburg General Store for some hand- The Rivers Casino an indoor pool, outdoor Jacuzzi, spa and more. Casino incentives dipped ice cream. No refunds after May 3. Capture the Fall Pittsburgh, PA are $60 slot play and $40 food. Hartville Marketplace Cost $58 Tuesday, September 30 8:30 a.m. – 5:00 p.m. Tuesday, November 30 $200pp/ Double Occupancy, $185pp/ Triple Occupancy Monday, May 17 City of Three Rivers Come with us as we head to 8:00 a.m. – 6:00 p.m. Friday, June 11 8:00 a.m. – 9:30 p.m. $294pp/ Single Occupancy, $170pp/ Quad Occupancy Sunrise Farms where everyone will We will head to the all new Casino located right at This facility houses 175 indoor shops, up 7:30 a.m. – 8:15 p.m. receive a mum to take home. From the Three Rivers. We will spend 5 hrs gambling then No refund is guaranteed after August 6 unless your reservation to 800 outdoor seasonal vendors, and 200 there we are off to Punderson State Spend a relaxing day cruising on the head to Hartwood Acres and view the wonderful is resold. Payment in full will secure your reservation and pavilion vendors. A delicious lunch at Park for lunch. After lunch we will head Three Rivers of Pittsburgh aboard the Christmas Light Display. Casino incentives are $10 reservations are taken on a first come, first serve basis. Hartville Kitchen is followed by time to to the West Woods Nature Center, Gateway Clipper. Enjoy beautiful city slot play and $5 food. No refunds after browse/shop through the Hartville Ridgeview Farm Market and an Amish sights, live entertainment and a delicious November 22. Collectibles. Hartville has preserved the School house. No refunds after lunch while on board. After your cruise Cost $25 country charm and excellent September 16. you'll enjoy a guided city tour and craftsmanship of the Mennonite Amish. Cost $63 shopping at Station Square. No refunds No refunds after April 17. Cost $41 after May 10. Cost $67 Mentor Senior Center 440.974.5725 or 440.255.1100, ext. 2470, www.cityofmentor.com/play/seniors Detailed flier for each trip is available at front desk or www.cityofmentor.com/play/seniors/trips. Overnight Trips Apple Butter Festival at Roscoe Village Gaylord Opryland Friday, October 15 January – Mallorca, Cleveland Tuesday, January 26 Nashville Getaway New York City Magic 8:00 a.m. – 6:30 p.m. Friday, July 9 – Monday, July 12 February – Blue Canyon Kitchen, Twinsburg Friday, April 23 – Monday, April 26 Come with us as we head to the annual Apple Butter Tuesday, February 23 Enjoy this 4 day, 3 night trip with lots to do and see in Festival which has something for everyone. You will March – Three Birds, Lakewood Join us for a 4 day, 3 night trip to Nashville, Tennessee. We will New York City. We will see a hit Broadway show, have experience a living history tour along with plenty of shops Tuesday, March 30 travel to Louisville, Kentucky where we will tour Historic Churchill in Little Italy, have a guided city tour including Central Park, to go in and explore. A canal boat ride on the Monticello III April – Blake's Seafood Restaurant, Westlake Downs and the Louisville Slugger Plant. In Nashville we will stay at Fifth Avenue, neighborhoods of NY as well as Ground is also included. No refunds after October 1. Tuesday, April 27 the luxurious Gaylord Opryland Hotel which is known for its Zero and St Paul's Cathedral. We will spend 2 nights Cost $48 May – Ferrante Winery and Ristorante, Geneva extraordinary service, luxurious accommodations and first-class lodging in Times Square. We will see the Top of the Rock THURSDAY, May 27 entertainment. We will have a guided tour of 'Music City'; we will and take Circle Line Ferry to Liberty and Ellis Island. A $150 June – Fahrenheit, Cleveland attend the Grand Ole Opry and tour the historic recording Studio B deposit is due March 1. Final payments are due by June 1. No SPECIAL OVERNIGHT TRIP Tuesday, June 29 and the Country Music Hall of Fame. The trip includes 1 night at refunds after June 1. Trip insurance is recommended. Travelex insurance forms are available at the desk and must be completed July – The Metropolitan Café, Cleveland the Drury Inn, 2 nights at the Gaylord Opryland Hotel and 3 Tuesday, July 27 breakfasts. A $200 deposit is due January 23. Final payment is within 21 days of deposit. Greece and Its Islands August – McCormick and Schmick's, Beachwood Tuesday, August 31 due by Feb. 15. No refunds after February 15. Trip insurance is $847pp/ Double Occupancy, $832pp/ Triple Occupancy, Classical Greece, Mykonos and Santorini recommended. Insurance forms are available at the desk and must September – La Dolce Vita, Little Italy $977pp/ Single Occupancy $807pp/ Quad Occupancy be completed within 21 days of deposit. Friday, September 17 – Friday, October 1 Tuesday, Sept 28 Discover the magnificent ruins of ancient Greece in October – The Oaks Lakeside, Chippewa Lake $745pp/Double Occupancy, $705pp/Triple Occupancy, $999pp/ Single Occupancy Finger Lakes Wine Tour Tuesday, October 26 Tuesday, August 17 – this tranquil Mediterranean setting. This well-paced 15-day journey, with deluxe accommodations, November – Blue Point Grille, Cleveland National Museum of Thursday, August 19 Tuesday, November 16 balances expeditions to Greece's most important December – Tre Belle, Bath the U.S. Air Force In the heart of the Finger Lakes lies one of the largest acreages Classical age monuments with ample time to wander Tuesday, December 14 Wednesday, May 5– Thursday, May 6 of vineyards in the country with more than 100 wineries. the winding streets, vineyards, boutiques, Experience some of these wineries as well as wonderful culinary Experience the oldest & largest military aviation museum in delights that will tease your palate. Dine in a Castle. Enjoy a marketplaces and beaches on Mykonos and Santorini. This is the Mentor Senior Center's twentieth year of the world! In the Presidential Gallery we will discover how past dinner cruise on Lake Canandaigua. An enjoyable and relaxing This special rate includes air fare, hotel transfers, Out to Lunch Bunch trips. Dates and locations could Presidents traveled including a walk through of President time in one of nature's playgrounds. You are sure to remember cruise on the Aegean Sea, 12 breakfasts and 8 change, so check the Mentor Senior Center's Roosevelt's Sacred Cow, Truman's Independence, this trip for a long time to come. A $150 deposit due by May 17. dinners. All Lake County Senior Centers are Eisenhower's Columbine III and Kennedy's Air Force One! Final payments are due by July 17. No refunds after July 1. Trip newsletter, www.cityofmentor.com/seniors/trips or Payment in full is needed by April 5. No refunds after April 5. offering this trip together. Please note that a call the center at 440-974-5725. insurance is recommended. Travelex insurance forms are available passport is required. A $250 deposit is due by March Trip insurance is recommended. Travelex insurance forms are at the desk and must be completed within 21 days of deposit. available at the desk and must be completed within 21 days of 1. Final payment is due by July 1. No refunds after deposit. $375pp/Double Occupancy, $341pp/Triple Occupancy, July 1. Cancellation waiver and trip insurance is $202pp/Double Occupancy, $179pp/Triple Occupancy, recommended and due with deposit. A detailed flier is $490pp/ Single Occupancy, $324pp/Quad Occupancy $268pp/ Single Occupancy, $168pp/Quad Occupancy available at front desk. We have selected some great local restaurants. Register and select your menu choices at the Senior Center. Provide your own $3874pp/Double Occupancy, $3824pp/ Triple Occupancy, transportation or request Laketran when you register and we'll arrange for you to get there. Enjoy some great food close to home, check out California Rail Discovery $4574pp/ Single Occupancy Wednesday, October 6 – that restaurant you've been wanting to try and enjoy the camaraderie Tuesday, October 12 of your Senior Center friends. A 7 day trip to California and Nevada featuring 3 nights first-class accommodations on Fisherman's Wharf, a San Francisco city tour Wednesday, February 10 – Brav0, Mentor and Bay cruise, a luxurious rail journey upon the Napa Valley Wine Train, a scenic rail journey through the beautiful Sierra Nevada Trip Refunds: Refunds will be available until the Wednesday, May 12 – Brennan's Fish House, mountains, 2 nights accommodations at a casino-resort in Lake Tahoe, a Lake Tahoe Paddle Wheeler Cruise and a visit to historic date specified, minus a $10 administrative fee. Grand River Virginia City and much more. All taxes, gratuities and baggage handling are also included. A deposit of $300 is required by May 1st to Prevent the $10 administrative fee by transferring Wednesday, August 4– Willoughby Brewing Co., reserve your seat. Final payments are due by July 23. No refunds after July 23. Trip insurance is recommended and due with deposit. Detailed flier is available at front desk or www.cityofmentor.com/play/seniors/trips. the full amount to another trip/class/program Willoughby $2149pp/ Double Occupancy, $2119pp/ Triple Occupancy, $2749pp/ Single Occupancy within the same season. Wednesday, November 10 – Noosa Bistro, Mentor
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With over ten years of experience in the industry, Superior Restoration is now providing the latest in advice and information for all aspects of water damage restoration. The blog is intended to offer general tips in preventative maintenance as well as clear up a lot of the common misunderstandings involved in the process. The end goal is to provide enough assistance to clients in order to prevent a lot of the common mishaps that can lead to flooding emergencies and avert disaster.
The blog is part of a massive website infrastructure overhaul that Superior Restoration has recently initiated in order to offer prospective and returning clients the best level of service possible. As part of their unwavering commitment to quality, the information provided in the articles will help keep customers informed and prepared for emergency situations.
Visitors to the blog can subscribe via e-mail or RSS feed to receive the latest updates when new articles are posted. Interested clients can also suggest topics of discussion for future articles via Twitter or e-mail as well to directly interact with the professionals at Superior Restoration.
For more details, please visit superiorrestore.blogspot.com. Be sure to follow on Twitter for all the latest news and announcements.


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Poll: What should I write for fun? Vote Now!
Author has written 6 stories for Fruits Basket, Hush, Hush, Phantom of the Opera, Darren Shan Saga/Cirque Du Freak, Inuyasha, and Naruto.
Hi guys! My name's Samantha and welcome to my profile :)
A little about me: I'm a 18 year old senior (whoohoo) in high school and I've been on this site for about four years now. I've been writing fic's for a long time but most are unfinished pieces of trash. Fun fact: I've never taken a break from FF.net. Even if the date of the last time I updated my stories tell you otherwise. I'm always reading fanfiction. Ad I'd be happy to read yours and even beta it if you want. It takes a lot to finish a story and kudos to you that are determined enough to do it. I'm still trying.
And in the style of Naruto here is more info about me for those of you that want to know:
American Horror Story
Sailor moon
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and Kyary Pamyu Pamyu
In case you haven't noticed I'm complete weeabo trash that likes to drool over manga boys when I'm not working at the old people home or playing lacrosse or scrolling through tumblr.
Speaking of which...
follow me @dragurself on tumblr. Lets be mutuals.
Add me on KaKao Chat and we can talk anime or writing (ID)sammi4451
That's all for now.
|love hush,hush? this is the palce for you!
|Books Hush, Hush


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Welcome to a free stock market game from MarketWatch.
With VSE you can:
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- What to expect from Alcoa's earnings
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Editors' Picks
Stocks to WatchDuPont, Nike, KB Home are stocks to watch
Among the companies whose shares are expected to see active trade in Friday's session are DuPont, Nike, and KB Home.
The StockpickersIliad to forge ahead with T-Mobile bid
Collapse of Sprint offer may strengthen Paris telecoms operator's hand.
The Ratings GameFireEye's stock hit by analyst downgrade
FireEye Inc.'s stock drops sharply after Barclays downgraded the cybersecurity company on concerns over valuation.


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The Journal Homemaker bring you all the latest home news from across the North East. Read the latest home stories, features and property listings from Tyne and Wear, Northumberland and County Durham.
Homemaker is published in The Journal every Saturday and is the North's leading homes & property supplement
The chance of living a true countryside lifestyle, yet still being accessible to the conurbation for work purposes, was what attracted Mark and Elaine Wilson to their historic cottage
This stunning Grade II Listed former pub is steeped in history and retains lots of beautiful original features
Saltwell Park is just a stone's throw away from this impressive detached home near Durham Road in Low Fell
The current owners of Bolam Hall Cottage fell in love with it at first sight and it's easy to see why
With five bedrooms and beautifully maintained gardens, this home built in 1923 is perfect for a family
Packed with Arts and Crafts features, Priorsgate House has been the happy country home of Richard and Rosalind Maudslay for the past 15 years
The Covers in Wallsend is proving a popular location for Bellway to build new homes which are now more affordable than ever thanks to Help to Buy, as our sponsored feature explains
This unusual property in Northumberland's most northerly town is packed with period features
Set in a rural location, this former Victorian School retains many original features and is within easy reach of Durham, Newcastle, and Hexham
Space and style are now on offer at Bellway's fantastic Teal Farm development in Washington - view pictures in our sponsored feature
This magnificent modern mansion in the Tynedale village of Wall has been filmed by television crews three times
Located in a wonderful countryside setting, this four-bedroom barn conversion is perfect for those that love the outdoors
Space and location were top of Karen Slater's tick-list when she was househunting for herself and her daughter 18 years ago
This striking Westerhope home features a large open-plan living room and a magnificent 33ft breakfasting kitchen/sun room
From cosy Christmases around the fire to an "outstanding" wedding, Thirston House has provided the perfect setting for the Reed family
This spilt-level home on the western edge of Rowlands Gill village, has spectacular views overlooking the Derwent Valley
Just perfect – that was what Karen and Chris Constable thought the first time they set eyes on their lovely country home
This stunning stone-built property in Stocksfield, Northumberland is the perfect family home
This impressive townhouse is set over three-storeys and includes four bedrooms and landscaped gardens
The Journal
For the latest local news straight to your Twitter, Facebook feed or e-mail inbox.
Is there something happening in your area you would like us to report on?
Interested in advertising? Please call 0191 201 6451 or click here
A key part of the region's business community The Journal has more ABC1 readers than any other quality regional morning newspaper on sale in the area.
The Journal has 99,273 average issue readers which increases to 209,957 weekly readers.
The average time spent reading The Journal is 33 minutes, which shows the length of time readers are engaging with editorial and advertising content.
23,291* copies of The Journal are sold on average each day, providing advertisers with extensive coverage of the region.
*ABC The Journal 97% Paid Mon - Sat, 1/10/2012 JICREG
Unique Users: 396,000
Page Impressions: 1,200,000
Audience figures from Omniture, monthly average (Jan-Jun 2014).
More than 1 in 3 Journal users have clicked through to an online advertisement, demonstrating that our users are responsive and receptive to Internet advertising messages.
TheJournal.co.uk reaches an internet-savvy audience, with 84% of users having purchased products or services online in the past 12 months.
Download our rate cards for all the prices of our print and digital products.
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Editor-in-Chief, Trinity Mirror North East
Darren was appointed editor of the Chronicle in September 2011, following a six-year spell as editor of the Evening Gazette in Teesside.
He has held a number of senior roles on regional newspapers across England, Scotland and Wales over the last 15 years and is now editor-in-chief of Trinity Mirror North East.


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You can now invite anyone to meet at your favorite Starbucks.
Limited-time feature
30 year old woman | Irvine, CA, USA | Seeking men 25-35 within 50 miles of Newport Beach, CA
We can say we met at Starbucks....
I'm a girl that likes watching sports, Sunday is probably my favorite day of the week, I LOOOOOOOVE the beach and the outdoors. People tend to call me "mom" all the time because I like to take care of my friends. I'm way to forgiving and give people way to many chances, I love to make people laugh and laughing till i cry, watching/going to movies, I'm pretty sure I could eat Sushi everyday of my life. I'm positive that I have the biggest sweet tooth EVER, aaaand if its spicy i'll love it! Music makes me happy and I could listen to it all day everyday. Camping is one of my favorite things to do. There's something about being away from technology, city lights, computers, traffic, the outside world... and just being with friends, family, and nature that makes me happy. My friends mean more to me then anything in the enitre world. I have the absolute best family a girl could ask for. I love taking pictures. I love love love VEGAS, could dance the night away, and might have a small addiction with gambling. The snow just makes me happy. Anything Disney I love (i'm a grown woman who has a disney playlist and proud of it) I'm all for going out and grabbing dinner and drinks and what not, but just staying in making dinner, renting a movie and cuddling on the couch all night is one of my favorite things to do with someone..... I get made fun of by all my friends when I watch tv shows and movies because almost every time I end up crying because I get waaaay into what I'm watching and think that I actually know the actor/character and feel what they feel.... but that's just me! I definitely want to travel the world someday.... If you like what you have read message me to find out more! :) Submitted from mobile
Camping , Coffee and conversation , Cooking , Dining out , Movies/Videos , Music and concerts , Exploring new areas , Nightclubs/Dancing , Performing arts , Playing cards , Travel/Sightseeing , Watching sports , Wine tasting
Aerobics, Dancing, Other types of exercise, Walking / Hiking, Weights / Machines
I exercise 3-4 times per week.
I like Cats, Dogs
Middle of the Road
I like going up to Mammoth or Big Bear in the winter, during the summer you'll find me at the beach, the pool, or the lake if I have the day off, My happiest place on Earth is Vegas, San Diego is always good times. Would love to travel more.
Moorpark College, Moorpark, CA
Love music of ALL kinds. Watch a random mix of tv shows, and I love food especaially sushi, anything with avocado is always good. Right now I'm obsessed with infusing my own alcohol. I'm in love with jalapeno margaritas
I like going out to get drinks and dinners with friends, going to movies, going out of town on the weekends for little mini vacays, anything outdoors, just started paddle boarding... so much fun, going to concerts, and absolutely love the beach.
I don't read on a regular basis.
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What she is looking for
|5'4" (162cms)
|5'10" (177cms) to 6'2" (187cms)
|Body type:
|About average
|About average, Athletic and toned
|No preference
|Dark brown
|No preference
|No Way
|No Way
|Social Drinker
|Social Drinker
|Retail / Food services
|No preference
|I'll tell you later
|No preference
|Never Married
|No preference
|Have kids:
|No preference
|Wants kids:
|White / Caucasian
|No preference
|I'll tell you later
|No preference
|Associates degree
|No preference


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A classic - without a doubt Mr. Harryhausen's best work. Back in the early 60s this stop motion was considered amazing work. Read morePublished 7 months ago by T. Stamatis
It is a PAL DVD. It may not work with your American playerPublished 8 months ago by J. Allan Moffatt
Remember this movie from growing up. It still has the same appeal to me. Thanks for making this available to me.Published 22 months ago by Tom Brown
Ray Harryhausen's work is a treat to watch, I have always been a fan of stop motion animation and will continue to collect all his worksPublished on May 29 2013 by maddog
I love this movie. I seen it as a teenager; and I still think its great.
A really true classic.


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eLong to Attend CIMB Asia Pacific Leaders' Conference on March 4 and 5, 2013
PR Newswire
BEIJING, Feb. 7, 2013
BEIJING, Feb. 7, 2013 /PRNewswire/ -- eLong, Inc. (Nasdaq: LONG - News ), a leading online travel service provider in China, today announced that the Company will participate in the CIMB Asia Pacific Leaders' Conference to be held on March 4 and 5, 2013 at Le Parker Meridien Hotel in New York City. Mr. Mike Doyle, CFO of the Company, is currently scheduled to meet with institutional investors on both days March 4 and 5, EST.
For additional information, please contact your CIMB representative.
About eLong, Inc.
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Venere.com is the perfect place to make all of your hotel bookings in Payson, Arizona! Check out our 9 Payson hotels, including a wide selection of accommodations, ranging from the super luxurious 5-star to the budget-conscious 2- and 1-star. Get the best value for your money with Venere. No matter what kind of accommodations you are looking for - ski, family, spa, sports, business, wellness, city center, adventure, golf or boutique hotels - we have the perfect hotel for your next vacation or business trip. Not sure which type of Payson hotel you want? Browse the 9 hotels on our interactive map to see exactly where they are located in Arizona. Carefully read the detailed hotel descriptions for even more information on the Payson area and the hotel you are interested in booking. Find out about the nearby tourist attractions, such as museums, beaches, shops, monuments, churches and exhibition centres. Learn all you need to know about each of the 9 accommodations offered at Venere. Even find hotels with onsite restaurants, pools, gyms, internet, concierge and business services. When traveling to Payson, Arizona - for work or pleasure, a quick weekend or an extended stay - check out Venere.com first. Venere has something to fit any budget. Get amazing discounts on Payson hotels. We update our inventory daily and are always adding new deals and sales for our 9 accommodations. Treat your special someone to a romantic weekend or book a fun-filled vacation for the entire family. Start by searching our easy-to-navigate website. Simply type Payson into the search box, then put in your travel dates and the number of rooms you need. Then simply look through all of the available accommodations among the 9 that Venere has to offer. Browse through all of the Payson hotels in the list and choose the ones that look good. Our gallery of photos will let you see what the hotel looks like inside and out. Read hotel descriptions for an overview of the hotel you chose in Arizona. Be sure to check for any available freebies, such as free Wi-Fi, breakfast and parking! Get all of the information about your room and location before making your final choice. Check out the hotel reviews from genuine Venere guests and Tripadvisor comments to see what others have to say about your Payson, Arizona accommodations. Learn all you can about your hotel choice and them book the perfect vacation accommodations with Venere.
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San Francisco, CAUSA 94105
October 11, 2013
We're using AngularJS for our mobile web site as well as for our mobile native applications through PhoneGap.
Both a developer and a hiring manager. And we're hiring!
Hard to pick just one. I really love the clean separation of responsibilities between sections of the codebase.
CTO and CoFounder of StyleSeat. Seeker of Challenge and Adventure.
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Comcast SportsNet Chicago and the White Sox have teamed up for a live auction to cap off 'Charities Week' at U.S. Cellular Field. CSN will host the '1983 Jerseys Off Our Back' auction during Sunday's series finale against the Kansas City Royals.
Beginning at 11:00 a.m., fans are encouraged to visit whitesox.com/jerseyauction for a chance to bid.
[RELATED: White Sox look to end skid against the Royals]
The auction features '83 throwback jerseys worn and autographed by select players in today's game against the Royals.
Players and coaches include: Addison Reed, Chris Sale, Paul Konerko, Adam Dunn, Alexei Ramirez, Gordon Beckham, Robin Ventura and Harold Baines.
Viewers will have a chance to place their bids online throughout the game with the auction ending at 3:00 p.m. this afternoon.


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text: Getty Images [ MinnesotaCare Stays Intact For Now In Brewing Budget Deal By The Associated Press May 15, 2015 Minnesota's public health care program for nearly 100,000 working poor residents will be preserved in an emerging budget deal. Read More|Comment Category: AP Stories, State/Regional News Tags: budget, minnesotacare, Politics Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


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Publications (22)87.15 Total impact
- SourceAvailable from: Andrzej Pilc
Article: Neuroprotective effects of mGluR II and III activators against staurosporine- and doxorubicin-induced cellular injury in SH-SY5Y cells: New evidence for a mechanism involving inhibition of AIF translocation[Show abstract] [Hide abstract]
ABSTRACT: There are several experimental data sets demonstrating the neuroprotective effects of activation of group II and III metabotropic glutamate receptors (mGluR II/III), however, their effect on neuronal apoptotic processes has yet to be fully recognized. Thus, the comparison of the neuroprotective potency of the mGluR II agonist LY354740, mGluR III agonist ACPT-I, mGluR4 PAM VU0361737, mGluR8 PAM AZ12216052 and allosteric mGluR7 agonist AMN082 against staurosporine (St-) and doxorubicin (Dox)-induced cell death has been performed in undifferentiated (UN-) and retinoic acid differentiated (RA-) human neuroblastoma SH-SY5Y cells. The highest neuroprotection in UN-SH-SY5Y cells was noted for AZ12216052 (0.01-1 µM) and VU0361737 (1-10 µM), with both agents partially attenuating the St- and Dox-evoked cell death. LY354740 (0.01-10 µM) and ACPT-I (10 µM) were protective only against the St-evoked cell damage, whereas AMN082 (0.001-0.01 µM) attenuated only the Dox-induced cell death. In RA-SH-SY5Y, a moderate neuroprotective response of mGluR II/III activators was observed for LY354740 (10 µM) and AZ12216052 (0.01 and 10 µM), which afforded protection only against the St-induced cell damage. The protection mediated by mGluR II/III activators against the St- and Dox-evoked cell death in UN-SH-SY5Y cells was not related to attenuation of caspase-3 activity, however, a decrease in the number of TUNEL-positive nuclei was found. Moreover, mGluR II/III activators attenuated the cytosolic level of the apoptosis inducing factor (AIF), which was increased after St and Dox exposure. Our data point to differential neuroprotective efficacy of various mGluR II/III activators in attenuating St- and Dox-evoked cell damage in SH-SY5Y cells, and dependence of the effects on the cellular differentiation state, as well on the type of the pro-apoptotic agent that is employed. Moreover, the neuroprotection mediated by mGluR II/III activators is accompanied by inhibition of caspase-3-independent DNA fragmentation evoked by AIF translocation. Copyright © 2014 Elsevier Ltd. All rights reserved.Neurochemistry International 02/2015; DOI:10.1016/j.neuint.2014.12.011 · 2.65 Impact Factor
Article: The impact of prenatal stress on insulin-like growth factor-1 and pro-inflammatory cytokine expression in the brains of adult male rats: The possible role of suppressors of cytokine signaling proteins[Show abstract] [Hide abstract]
ABSTRACT: Stress, inflammation and the reduced expression of neurotrophic factors are risk factors for depression. The objective of this study was to determine if prenatal stress affects IGF-1 – cytokine interactions by influencing suppressors of cytokine signaling (SOCS) in the brains of adult rats, in basal conditions and after acute lipopolysaccharide (LPS) treatment. We demonstrated that prenatal stress leads to depression-like behavior, decreased IGF-1, increased IL-1β, TNF-α and IFN-γ release and disturbed SOCS-1, SOCS-2 and SOCS-3 expression in the hippocampus and frontal cortex of adult offspring. Furthermore, prenatal stress enhances the brain response to LPS-evoked inflammatory challenges.Journal of Neuroimmunology 11/2014; DOI:10.1016/j.jneuroim.2014.08.001 · 2.79 Impact Factor
Article: Prenatal stress affects insulin-like growth factor-1 (IGF-1) level and IGF-1 receptor phosphorylation in the brain of adult rats[Show abstract] [Hide abstract]
ABSTRACT: It has been shown that stressful events occurring in early life have a powerful influence on the development of the central nervous system. Insulin-like growth factor-1 (IGF-1) promotes the growth, differentiation and survival of both neurons and glial cells and is thought to exert antidepressant-like activity. Thus, it is possible that disturbances in the function of the IGF-1 system may be responsible for disturbances observed over the course of depression. Prenatal stress was used as a valid model of depression. Adult male offspring of control and stressed rat dams were subjected to behavioural testing (forced swim test). The level of IGF-1 in the blood and the expression of IGF-1, IGF-1R, IRS-1/2 in the hippocampus and frontal cortex using RT-PCR, ELISA and western blotting were measured. Additionally the effect of intracerebroventricularly administered IGF-1 and/or the IGF-1R receptor antagonist JB1 in the forced swim test was studied. Prenatally stressed rats showed depressive like behaviour, including increased immobility time as well as decreased mobility and climbing. Intracerebroventricular administration of IGF-1 reversed these effects in stressed animals, whereas concomitant administration of the IGF-1R antagonist JB1 completely blocked the effects. Biochemical analysis of homogenates from the hippocampus and frontal cortex revealed decreases in IGF-1 level and IGF-1R phosphorylation along with disturbances in IRS-1 phosphorylation. These findings reveal that prenatal stress alters IGF-1 signalling, which may contribute to the behavioural changes observed in depression.European Neuropsychopharmacology 09/2014; 24(9). DOI:10.1016/j.euroneuro.2014.07.002 · 5.40 Impact Factor
Article: Antidepressants attenuate the dexamethasone-induced decrease in viability and proliferation of human neuroblastoma SH-SY5Y cells: A involvement of extracellular regulated kinase (ERK1/2).[Show abstract] [Hide abstract]
ABSTRACT: Excessive glucocorticoid levels in depressed patients have been associated with atrophic changes in some brain regions, but only few studies suggest that some antidepressants can interfere with deleterious effect of glucocorticoids on neuronal cells. The aim of the present study was to examine the effect of dexamethasone (DEX), a synthetic glucocorticoid and some antidepressants from different chemical groups (imipramine, desipramine, amitryptiline, citalopram, fluoxetine, reboxetine and tianeptine) on SH-SY5Y cells cultured in the medium containing steroid-free serum. DEX in concentrations from 1-100 μM did not change LDH release but exposure to 10 μM and 100 μM DEX for 24, 48 and 72 hr caused a significant reduction in cell viability and proliferation as confirmed by MTT reduction and BrdU ELISA assays, respectively. Twenty four-hour incubation of cells with antidepressants (0.05-10 μM) and DEX (10 μM) showed that imipramine, amitryptyline, desipramine, citalopram and fluoxetine at concentrations from 0.1 up to 1 μM, reboxetine (0.1 μM) and tianeptine (0.05 μM) prevented the DEX-induced decreases in cell viability and proliferation rate. The protective effects of antidepressants were ameliorated by inhibitors of MAPK/ERK1/2, but not PI3-K/Akt pathway as shown for imipramine, fluoxetine and reboxetine. Moreover, Western blot analysis showed the decrease in the activated form of ERK1/2 (p-ERK) after DEX treatment and this effect was inhibited by imipramine. Thus, the reduction in SH-SY5Y cell viability caused by DEX appears to be related to its antiproliferative activity and some antidepressant drugs in low concentrations attenuate this effect by mechanism which involves the activation of MAPK/ERK1/2 pathway.Neurochemistry International 07/2013; DOI:10.1016/j.neuint.2013.07.007 · 2.65 Impact Factor
Article: Stimulatory effect of antidepressant drug pretreatment on progression of B16F10 melanoma in high-active male and female C57BL/6J mice[Show abstract] [Hide abstract]
ABSTRACT: The effect of a two-week desipramine or fluoxetine (10 mg/kg, i.p.) pretreatment on B16F10 melanoma growth in 3-5 month old female and male C57BL/6J mice differing in behavioral characteristics (high- vs. low-active) was compared. Antidepressant pretreatment increased metastasis formation, shortened the survival, decreased splenocyte anti-tumor natural killer cell cytotoxicity (in vitro), and the pro-inflammatory cytokine IL-12p40, IFN-γ production while it increased anti-inflammatory cytokine IL-10 production in high-active males (desipramine) or females (fluoxetine). The obtained results emphasize a stimulatory effect of pretreatment with antidepressants on progress of B16F10 melanoma that depends on gender and behavioral characteristics of the animal.Journal of neuroimmunology 12/2011; 240-241:34-44. DOI:10.1016/j.jneuroim.2011.09.006 · 2.79 Impact Factor
Article: P.2.b.003 Expression of the insulin-like growth factor-1 receptor in the rat hippocampus following prenatal stressEuropean Neuropsychopharmacology 09/2011; 21. DOI:10.1016/S0924-977X(11)70591-0 · 5.40 Impact Factor
- European Neuropsychopharmacology 09/2011; 21. DOI:10.1016/S0924-977X(11)70601-0 · 5.40 Impact Factor
- European Neuropsychopharmacology 09/2011; 21. DOI:10.1016/S0924-977X(11)70653-8 · 5.40 Impact Factor
Article: P.2.b.008 Emerging role of the IGF family in prefrontal cortex dysfunction in animal model of depressionEuropean Neuropsychopharmacology 09/2011; 21. DOI:10.1016/S0924-977X(11)70596-X · 5.40 Impact Factor
Article: Protective effects of TRH and its analogues against various cytotoxic agents in retinoic acid (RA)-differentiated human neuroblastoma SH-SY5Y cells[Show abstract] [Hide abstract]
ABSTRACT: TRH (thyroliberin) and its analogues were reported to possess neuroprotective effects in cellular and animal experimental models of acute and chronic neurodegenerative diseases. In the present study we evaluated effects of TRH and its three stable analogues, montirelin (CG-3703), RGH-2202 and Z-TRH (N-(carbobenzyloxy)-pGlutamyl-Histydyl-Proline) on the neuronally differentiated human neuroblastoma SH-SY5Y cell line, which is widely accepted for studying potential neuroprotectants. We found that TRH and all the tested analogues at concentrations 0.1-50 μM attenuated cell damage induced by MPP(+) (2 mM), 3-nitropropionate (10 mM), hydrogen peroxide (0.5 mM), homocysteine (250 μM) and beta-amyloid (20μM) in retinoic acid differentiated SH-SY5Y cells. Furthermore, we demonstrated that TRH and its analogues decreased the staurosporine (0.5 μM)-induced LDH release, caspase-3 activity and DNA fragmentation, which indicate the anti-apoptotic proprieties of these peptides. The neuroprotective effects of TRH (10 μM) and RGH-2202 (10 μM) on St-induced cell death was attenuated by inhibitors of PI3-K pathway (wortmannin and LY294002), but not MAPK/ERK1/2 (PD98059 and U0126). Moreover, TRH and its analogues at neuroprotective concentrations (1 and 10 μM) increased expression of Bcl-2 protein, as confirmed by Western blot analysis. All in all, these results extend data on neuroprotective properties of TRH and its analogues and provide evidence that mechanism of anti-apoptotic effects of these peptides in SH-SY5Y cell line involves induction of PI3K/Akt pathway and Bcl-2. Furthermore, the data obtained on human cell line with a dopaminergic phenotype suggest potential utility of TRH and its analogues in the treatment of some neurodegenerative diseases including Parkinson's disease.Neuropeptides 12/2010; 44(6):495-508. DOI:10.1016/j.npep.2010.08.004 · 2.55 Impact Factor
Article: Opposite effect of fluoxetine treatment on C26 murine colon carcinoma liver metastasis formation and B16F10 melanoma growthBrain Behavior and Immunity 08/2010; 24. DOI:10.1016/j.bbi.2010.07.115 · 6.13 Impact Factor
Article: The decrease in JNK- and p38-MAP kinase activity is accompanied by the enhancement of PP2A phosphate level in the brain of prenatally stressed rats.[Show abstract] [Hide abstract]
ABSTRACT: Our previous study suggests that in prenatal stress model of depression glucocorticoid receptor (GR) function in adult rats is enhanced. However, the long-term consequences of stress, a causal factor in depression, on intracellular elements involved into the regulation of GR function is poorly examined. Mitogen-activated protein kinases (MAPKs), activity of which is disturbed in depression, are important regulators of GR action, so they can mediate the effect of stress on GR function. Therefore, the aim of the present study was to investigate the levels of active phosphorylated forms of extracellular signal-regulated kinases (ERK), Jun N-terminal kinases (JNK) and the p38 kinase in the hippocampus and frontal cortex in rats subjected to prenatal stress. The concentration of MAP kinase phosphatase (MKP-1, MKP-2) and protein phosphatase-2A (PP2A), which dephosphorylate all forms of MAP kinases, were also determined. During verification of the applied model of depression, we found that prenatally stressed rats displayed high level of immobility in the Porsolt test and that the administration of imipramine, fluoxetine, mirtazapine and tianeptine for 21 days normalized this parameter. Western blot study revealed that rats subjected to prenatal stress had decreased levels of p-JNK1 and p-JNK2 in the hippocampus and p-p38 in the frontal cortex, but the concentrations of p-ERK1 and p-ERK2 were not changed. Chronic treatment with imipramine inhibited the stress-induced decrease in p-JNK1/2, while imipramine, fluoxetine and mirtazapine blocked changes in p-p38. PP2A phosphatase level was higher in the hippocampus and frontal cortex in prenatally stressed animals than in control rats. Chronic treatment with antidepressant drugs attenuated the stress-induced increase in the level of this phosphatase, but had no effect on its concentration in control animals. There was no significant difference in MKP-1 and in MKP-2 levels in both brain structures between control and prenatally stressed rats. The obtained results showed that prenatal stress decreased the levels of active form of JNK and p38, but enhanced PP2A phosphatase expression and most of these changes were reversed by antidepressant drugs. Since p-JNK and p-p38 are known to inhibit GR function their lowered levels may enhance glucocorticoid action. Furthermore, the increased PP2A concentration may intensify GR action not only by inhibition of JNK and p38 phosphorylation, but also by a direct influence on the process of GR translocation.Journal of physiology and pharmacology: an official journal of the Polish Physiological Society 04/2010; 61(2):207-15. · 2.72 Impact Factor
Article: P.3.f.004 Regulation of the GABA cell phenotype in neurodevelopmental model of schizophrenia in ratsEuropean Neuropsychopharmacology 09/2009; 19. DOI:10.1016/S0924-977X(09)70933-2 · 5.40 Impact Factor
Article: P.3.f.002 Effect of MK-801 on lipopolysaccharide (LPS)-induced sensorimotor gating impairments in neurodevelopmental model of schizophrenia in ratsEuropean Neuropsychopharmacology 09/2009; 19. DOI:10.1016/S0924-977X(09)70931-9 · 5.40 Impact Factor
Article: Excitatory neurosteroids attenuate apoptotic and excitotoxic cell death in primary cortical neurons.[Show abstract] [Hide abstract]
ABSTRACT: Some neurosteroids show neuroprotective action in in vitro and in vivo studies, but their interaction with apoptotic/necrotic processes has been only partially unraveled. The aim of the present study was to examine the effect of dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), pregnenolone (PGL) and allopregnanolone (Allo) on staurosporine-, glutamate-, and NMDA-induced damage in primary cortical neuronal culture. DHEA, DHEAS and PGL (0.1 and 1 microM) inhibited the staurosporine-evoked LDH release and decreased the number of apoptotic cells as shown by Hoechst;s staining, whereas Allo was without effect. The neurosteroids affected neither the staurosporine-evoked changes in caspase-3 activity nor the decrease in mitochondrial membrane potential. It was also shown that protective effects of DHEA, DHEAS and PGL against staurosporine-induced LDH release were attenuated by extracellular signal-regulated kinase (ERK)--mitogen-activated protein kinase (MAPK) inhibitor--PD 98059 (5 microM) but not by phosphatidylinositol-3-kinase (PI3-K) inhibitors such as LY 294002 (1 microM) or wortmannin (10 nM). The involvement of ERK2-MAPK in protective effects of neurosteroids was confirmed by Western blot study. Further study demonstrated that glutamate-induced cell damage was attenuated by DHEA, DHEAS, and PGL, but not by Allo. None of the steroids influenced NMDA-induced LDH release. The results of the present in vitro studies suggest that excitatory neurosteroids DHEA, DHEAS and PGL at physiological concentrations participate in the inhibition of cortical neuronal degeneration elicited by staurosporine and glutamate, whereas the most potent positive modulator of GABA(A) receptor--Allo--has no effect. Moreover, neurosteroids appear to attenuate the staurosporine-induced cell damage in a caspase-3 independent way and their neuroprotective mechanism of action involves the increase in ERK-MAPK phosphorylation.Journal of physiology and pharmacology: an official journal of the Polish Physiological Society 10/2008; 59(3):457-75. · 2.72 Impact Factor
Article: Immunosuppression induced by a conditioned stimulus associated with cocaine self-administration.[Show abstract] [Hide abstract]
ABSTRACT: Cocaine addiction is known to impair immune system function, but the effects of repeated treatment with cocaine in a self-administration model, its withdrawal as well as reinstatement of cocaine-seeking behavior on cell-mediated immunity are not well known. Cocaine self-administered for 18 days induced a significant increase in spleen weight, plasma corticosterone levels, interleukin (IL)-10, and tumor necrosis factor-alpha production, while concanavalin A-stimulated proliferation responses of peripheral blood T-lymphocytes and interferon-gamma production by splenic lymphocytes were not altered. After 10 days withdrawal from cocaine, reinstatement of cocaine seeking behavior induced either by a priming dose of the drug (unconditioned stimulus), by cue previously associated with cocaine self-administration (conditioned stimuli), or by both these stimuli evoked similar changes in several immunological parameters, for example, a decrease in relative spleen weight, proliferative activity of splenocytes, and their ability to produce IL-10. The results showed that the cue previously associated with cocaine suppressed some parameters of cell-mediated immunity to the same degree as re-exposure to cocaine. The present study provides the first evidence that alterations of immune status can be conditioned by environmental stimuli paired with cocaine administration.Journal of Pharmacological Sciences 09/2008; 107(4):361-9. DOI:10.1254/jphs.FP0072106 · 2.11 Impact Factor
Article: Effects of neurosteroids on hydrogen peroxide- and staurosporine-induced damage of human neuroblastoma SH-SY5Y cells[Show abstract] [Hide abstract]
ABSTRACT: Neurosteroids are important regulators of central nervous system function and may be involved in processes of neuronal cell survival. This study was undertaken to test the effect of dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), pregnenolone (PGL), pregnenolone sulfate (PGLS), and allopregnanolone (Allo) on hydrogen peroxide- and staurosporine-induced toxicity in SH-SY5Y cells. It has been found that DHEAS inhibited the hydrogen peroxide toxicity in a concentration-dependent manner, whereas DHEA was active only at higher doses. PGL and PGLS showed neuroprotective effects only at the lowest concentration. Allo had no significant effect on hydrogen peroxide-evoked lactate dehydrogenase release and at the highest concentration aggravated its toxic effects. Next part of this study evaluated neurosteroid effects on staurosporine-induced apoptosis. DHEAS, DHEA, and PGL significantly antagonized effects of staurosporine on both caspase-3 activity and mitochondrial membrane potential. PGLS and Allo inhibited the staurosporine-induced changes in both apoptotic parameters only at the lowest concentration. Antiapoptotic properties of neurosteroids were positively verified by Hoechst staining. Furthermore, as shown by calcein assay, DHEA, DHEAS, and PGL increased viability of staurosporine-treated cells, and these effects were attenuated by specific inhibitors of phosphatidylinositol 3-kinase (PI3-K) and extracellular signal-regulated protein kinase (ERK)-mitogen activated protein kinase (MAPK). These data indicate that neurosteroids prevent SH-SY5Y cell damage related to oxidative processes and activation of mitochondrial apoptotic pathway. Moreover, neuroprotective effects of DHEA, DHEAS seem to depend on PI3-K and ERK/MAPK signaling pathways. It can be suggested that, at physiological concentrations, all studied neurosteroids participate in the inhibition of neuronal apoptosis, but with various potencies.Journal of Neuroscience Research 05/2008; 86(6):1361-70. DOI:10.1002/jnr.21591 · 2.73 Impact Factor
Article: The attenuating effect of memantine on staurosporine-, salsolinol- and doxorubicin-induced apoptosis in human neuroblastoma SH-SY5Y cells.[Show abstract] [Hide abstract]
ABSTRACT: Memantine, a clinically used N-methyl-D-aspartate (NMDA)-receptor antagonist, has been shown to prevent apoptotic neuronal damage connected with the over-activity of NMDA receptors. In the present study, we examined the effect of memantine on staurosporine-, salsolinol- and doxorubicin-induced apoptosis in the SH-SY5Y cell line which does not possess functional NMDA receptors. Electrophysiological recordings and toxicity studies showed no response to NMDA-evoked currents in this cell line, irrespective of the stage of its neuronal differentiation. Memantine (0.1-2 microM) attenuated staurosporine-induced apoptosis as evidenced by reversal of the changes in mitochondrial membrane potential (DeltaPsi(m)) and decreased caspase-3 activity, lactate dehydrogenase (LDH) release and DNA fragmentation. Wortmannin (10 nM) and LY 294002 (10 microM) (inhibitors of phosphatidylinositol-3-kinase, PI3-K) reversed the inhibitory effect of memantine on the staurosporine-induced LDH release, suggesting that the PI3-K/Akt prosurvival pathway is a possible target for antiapoptotic action of memantine. Memantine at low micromolar concentrations also attenuated salsolinol- and doxorubicin-induced LDH release and DNA fragmentation, but only in the case of salsolinol was this effect accompanied by a decrease in caspase-3 activity. The present data indicate that memantine attenuates the toxic effects of various proapoptotic agents and the cytoprotective effect of memantine does not seem to be connected with its action on NMDA receptor but rather with its influence on intracellular pathways engaged in cellular survival/apoptotic processes.Neurochemistry International 03/2008; 52(4-5):864-77. DOI:10.1016/j.neuint.2007.10.003 · 2.65 Impact Factor
Article: P.1.27 The effect of antidepressant drugs on the HPA axis activity, glucocorticoid receptor and FK506 binding protein 51 (FKBP-51) concentration in animal model of depressionEuropean Neuropsychopharmacology 03/2008; 18. DOI:10.1016/S0924-977X(08)70028-2 · 5.40 Impact Factor
Article: Memantine ameliorates salsolinol- and staurosporine-induced toxicity in serum deprived SH-SY5Y cellsBehavioural Pharmacology 09/2006; 17. DOI:10.1097/00008877-200609000-00067 · 2.19 Impact Factor
Top Journals
Polish Academy of Sciences
Warszawa, Masovian Voivodeship, Poland
- • Department of Experimental Neuroendocrynology
- • Institute of Pharmacology


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Mayor: Boston Games Overruns Not On Taxpayers USOC Praises Boston 2024's Progress Officials Withhold Judgement On Boston Bid 2.0 New Boston Bid Boston 2024 Can't Find Home For Velodrome Sources: USOC Encouraged By Boston '24 Tweaks USOC Polling Boston Residents On '24 Olympics USOC Tries To Woo Potential Rio Games Sponsors Poor Poll Numbers Should Not Hurt Boston '24 Boston '24 Moves Beach Volleyball Out Of City
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Published May 28, 2014
GETTING COLD FEET? YAHOO SPORTS' Jay Busbee noted residents of Krakow, Poland, "overwhelmingly rejected the idea of hosting the 2022 Games," leading city officials to withdraw the bid Monday. This follows three other potential hosts -- Stockholm; Munich; and Davos/St. Moritz, Switzerland -- that have decided not to bid for the event. Two more cities' bids, while "not technically dead, may as well be." Lviv, Ukraine, is "having real military issues and can't afford to waste time thinking about the Olympics," while Oslo's bid is "floundering politically." Busbee: "Why the sudden mass exodus from hosting? Because cities with an eye for financial reality have seen the results." It is "no surprise" that the only two cities seriously still in the running for '22 are Almaty, Kazakhstan, and Beijing, China -- "two locales where the people don't get a choice in whether the Games come or not" (SPORTS.YAHOO.com, 5/27). The WALL STREET JOURNAL's Matthew Futterman wrote what "once looked like a very competitive race" for the '22 Games is "looking more and more like a devil's choice" between Almaty and Beijing, neither of which "tops anyone's list of leading winter sports destinations." If the USOC had "decided to go ahead with a 2022 bid, it likely would have won in a walk" (WSJ.com, 5/27). SLATE.com's Joshua Keating wrote, "If we do end up watching slopestyle from the Central Asia steppes in 2022, it will likely be because it's becoming clear that nobody in Europe wants to host the Winter Olympics anymore" (SLATE.com, 5/27).


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by Heather Rivera
posted May 14 2012 10:14AM
7-11 is debuting the 'Surplee LIte Sugar-free Mango' in June! It's made with Splenda, and has 20 calories per 8 ounce serving. On May 23rd, '7-11 SlurpFree Day', this flavor will be available to try for FREE! Other flavors like their popular Wild Cherry (64 calories per 8 ounce serving), Strawberry Banana and more are expect sugar-free for this 2012 Summer! I'm figuring it will still burn if you laugh while drinking it and it comes out your nose. I suggest you try not to do that. Experience has taught me that rough lesson. :)
7-Eleven will offer free
7.11-ounce Slurpees on "SlurpFree Day" May 23. Lite Mango (and other flavors) will be available, but not two sugar-free flavors due this summer: strawberry banana and cherry limeade.
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StartUpHire is the place to find Junior Developer jobs. Review the list of Junior Developer career opportunities to the left. These Junior Developer jobs represent some of the most rewarding careers available.
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Article ID: 175627
When you click Start, point to Programs, and then click Windows Explorer or Windows NT Explorer, you may receive the following prompt:
The item "Explorer.scf" that this shortcut refers to has been changed or moved. The nearset match based on size, date, and type is <file name>. Do you want this shortcut to point to this item?
This behavior can occur if you remove the Windows Desktop Update component and click No when you are prompted to remove the personalized settings for Windows Explorer.
To resolve this behavior, change the shortcut to Windows Explorer or Windows NT Explorer so that it points to the Explorer.exe file. To do so, follow these steps:
More information
The option to remove personalized settings for Windows Explorer is intended for people who use roaming profiles. If you remove the Windows Desktop Update component and click No when you are prompted to remove your personalized settings, the Windows Explorer or Windows NT Explorer shortcut still points to the Explorer.scf file even though it has been removed from your hard disk.
Article ID: 175627 - Last Review: June 22, 2014 - Revision: 5.0
Retired KB Content Disclaimer
This article was written about products for which Microsoft no longer offers support. Therefore, this article is offered "as is" and will no longer be updated.
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Feed aggregator
Canal+ outlines Polish changes
The number of Canal+-branded channels available in Poland will be increased to eight at the beginning of next month. Read the story »
Spike Lee is reportedly making a movie for Amazon
Amazon has scored a coup for its new film production arm by signing Oscar-nominated director Spike Lee for his next film, according to a report from the Wrap. Called Chiraq, the project is reportedly set in Chicago and revolves around a the city's gun violence (Chiraq is a derogatory mashup of "Chicago" and "Iraq"). Lee is said to be pursuing Samuel L. Jackson and native Chicagoans Jeremy Piven, Common and Kanye West to star. The deal marks the first big splash for Amazon Original Movies, an Amazon Studios venture aimed at producing films for theatrical release and Prime Instant Video streaming.
Filed under: Home Entertainment, HD, Amazon
Source: The Wrap
Beamly tops 10 million users
Beamly, the social TV app that launched as Zeebox, has seen an 11 fold increase in users since its relaunch 12 months ago. Read the story »
'Mario Kart 8' is about to get absurdly fast
How big of a difference do those extra 50 cubic centimeters in Mario Kart 8 make? Well, Iwata and Co. have a video showing the current fastest/most difficult setting (150cc) side by side with the 200cc level the outfit announced last week. The trip around Piranha Plant Slide starts out slowly enough, but it isn't long before the differences start to show. There's roughly a five second gap between when Mario passes the first eponymous flora on the 200cc speed and 150cc, for instance, and the lead only grows from there. By the end of the lap, the lead is almost 15 seconds. That's quite a bit! Anywho, the video, along with a few others, is just below and the free update hits April 23rd -- see you on Rainbow Road.
Filed under: Gaming, Home Entertainment, HD, Nintendo
Via: Destructoid
Source: Nintendo Wii U UK (YouTube)
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Starz Play Arabia has launched in 17 countries
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Xite names Marius Brok director distribution partnerships
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Digital release for all Star Wars movies
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'Battlebots' reboot will air on ABC June 21st
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[Image credit: nerdabout/Flickr]
Filed under: Home Entertainment, HD
'Grand Theft Auto' drama from BBC may star Daniel Radcliffe
Yer a video game magnate, Harry.
BBC Films is working on Grand Theft Auto, a drama about the real-life founder of Rockstar Games, Sam Houser, and his battles over the perception of video game violence with bombastic, disbarred attorney Jack Thompson in the early 2000s. Thompson's role hasn't yet been cast, but Daniel Radcliffe, the actor best known for playing Harry Potter in all eight of those films, is in negotiations to play Houser, THR reports. Owen Harris, a British director responsible for a few episodes of Misfits and the season two premiere of Black Mirror, is on board for Grand Theft Auto. The script was penned by TV writer James Wood, with producer Jim Spencer and executive producer Mark Hedgecoe. It's scheduled to begin shooting on April 20 (no word on if it will be in 60FPS).
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YouTube's ad-free video subscription could arrive before year's end
Google announced YouTube's Music Key streaming subscription last fall, and an ad-free video service is also said to be on the way. Bloomberg reports the paid plan that nixes those pre-roll advertisements will launch before the end of the year, citing a source familiar with the project. The company sent a letter to YouTube partners today painting the broad strokes, including a mention of the upcoming paid tier and updated terms. "By creating a new paid offering, we'll generate a new source of revenue that will supplement your fast growing advertising service," the letter explains. Details are scarce at the moment, but we'll certainly hear more about things like pricing and offline playback in the weeks to come. The aforementioned Music Key service launched late last year, and there was a pilot program for paid channels in 2013, so the idea of paying for YouTube content isn't new. It also offers a Kids option, and there's likely a ton of folks who'd pay a (small) fee to skip those awful Progressive ads.
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Source: Bloomberg
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Filed under: Home Entertainment, HD, Apple
Source: Design Crumbs, takemymoneyhbo.com, HBO (YouTube)


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Abu Dhabi's TAQA drops 5.4 pct after saying no merger talks
Qatar's Doha Bank raises 2 bln riyal Tier 1 capital-boosting bond
Dubai's Drake & Scull increases GCC ownership limit to 100 pct
Abu Dhabi's TAQA says not holding merger talks
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Qatar Holding, a unit of the gas-rich Gulf state's sovereign wealth fund, is bullish on emerging economies, its chief executive told reporters on Sunday.
April 22, 2012 4:03 by kippreport
Qatar Holding, a unit of the gas-rich Gulf state's sovereign wealth fund, is bullish on emerging economies, its chief executive told reporters on Sunday.
"We are very optimistic on Brazil and other emerging economies," Ahmad al-Sayed said on the sidelines of a conference.
Qatar's sovereign wealth fund, like most Gulf funds, has traditionally preferred investing in Western markets, picking up stakes in companies ranging from carmakers to banks.
In recent years, though, the Gulf funds have increasingly spoken of diversifying the geographical spread of their investments by looking to Asia and other emerging markets.
(Reporting by Regan Doherty; Writing by Sitaraman Shankar)
It isn't easy being green. Or is it?
April 22 2012
Canada's RBC to Double Middle East Wealth Management Team
April 22 2012


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A team led by a University of Maryland School of Medicine (UM SOM) researcher, working as a grantee from the National Institutes of Health (NIH), has identified a number of existing drugs that could be "repurposed" to fight outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV).
Clinicians treating patients suffering from MERS currently have no drugs specifically targeted to the MERS-CoV, a virus first detected in humans in 2012 that has since caused 572 laboratory-confirmed infections, including 173 that were fatal, according to the World Health Organization. Public health officials announced the first two cases of the virus in the United States in early May.
In a paper published online in Antimicrobial Agents and Chemotherapy on May 19, 2014, Matthew Frieman, PhD, Assistant Professor of Microbiology and Immunology, at UMSOM and his colleagues report that they found more than 60 drugs that inhibited MERS-CoV and SARS-CoV. These drugs, which either were approved by the FDA for another condition or are in advanced clinical trials, provide new targets for possible development into antiviral therapies.
"Outbreaks of emerging viruses present a unique challenge: How to quickly identify treatments without requiring the full-term, lengthy clinical development process," said Dr. Frieman. "Repurposing approved pharmaceuticals offers a feasible, safe way to quickly find ways to quell an outbreak and reduce the loss of life. In fact, in a fast-moving outbreak, it may be the only way to find treatments."
Frieman and his colleagues tested about 290 compounds against viruses that were grown in a laboratory. These compounds were selected for their antiviral activity observed from previous tests, as well as structures and functions that suggested they might contain some ability to thwart a viral infection and outbreak. From those 290 compounds, the researcher
|Contact: Jamie Lacey-Moreira
University of Maryland School of Medicine


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(kē´werd) (1) In text editing and database management systems, a keyword is an index entry that identifies a specific record or document.
(2) In programming, a keyword is a word that is reserved by a program because the word has a special meaning. Keywords can be commands or parameters. Every programming language has a set of keywords that cannot be used as variable names. Keywords are sometimes called reserved names .
(3) A word used by a search engine in its search for relevant Web pages.
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