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Oh yes here we go beating this "dead horse again' with this chick Sara. Here is the latest article and here once again is what I think.
Parents of Special-Needs Children Divided Over Palin's Promise to Help
By Jennifer Steinhauer and Amy Harmon tinyurl.com/5n8dmq
Amid the barbs and hockey banter Wednesday night, Gov. Sarah Palin directed an emotional appeal to the hearts of millions of parents with children who have special needs, promising they would "have a friend and advocate in the White House" in a McCain-Palin administration. As she spoke, the camera panned to her baby, Trig, who has Down syndrome. (1) Yeah lady sure make your plea for something you have no idea about. You cant advocate for us, you dont even know us.)
Ms. Palin's offer of friendship sparked hope in many parents, advocates and lawyers as the often-marginalized subject of disabilities rights took center stage. "We need one, that's for sure," wrote one blogger, Rhymerchick, a Phoenix mother with an autistic child, adding, "I am tempted to vote for them just because of that promise."
(When it comes to our kids especially those with special needs ladies, gentle men please please dont vote on emotions. Think about your child, think about all the other empty promises that have been made due to people we trust to make things better for our kids and all they get are bag of rocks where the promises use to be)
In animated debates in blogs, chat rooms and classrooms across America, others wondered what such advocacy would entail. But the governor offered no details, and Maria Comella, her spokeswoman, would not elaborate on what Ms. Palin would seek to accomplish for disabled children as vice president. "She is going to be an advocate in the White House on multiple levels," Ms. Comella said in an e-mail message Friday, "because she understands the issue, what's needed and what works."
(So you have no plan, you just want us to trust on blind faith that you are going to come in and change things? Thats just like me saying hey I had a dog once so I am going to run for Vet of the year so I can change the way things are done for Pet Care Rights so vote for me I understand your pain. No we need facts woman, stop all of your lally gagging and tell us what you plan to do. Are you gonna supply us wth better teacher, more funding for Occupational, Physical, Speech therapy. Are you going to offer up sypmathy training for School Staff? Better bussing services for our kids. More IEP rights well huh huh are you are you? Make up a plan stan or step away before you cause more harm to the Special Needs Community then needs be)
To those in Alaska who work with children with special needs, Ms.
Palin's pronouncement was surprising; the disabled have not been a centerpiece of Ms. Palin's 20-months in office or any of her campaigns for office.
She signed legislation that would increase financing for children in Alaska with special needs — though she was not involved in its development — yet that state is the subject of two lawsuits that allege inadequate services and financing for those children, particularly those with autism.
( Ha so let me get this straight first you cut the Special Needs Funding down by 62% then you go back and sign a bill but you never never ever ever got invovled in develeoping it? Are you freaking kidding me woman? So now Alaska the State you so well governed is being sued due to your sigh negelance and you want us here to trust you with our kid? I be zip the damn fool if I do that. See I can see you know you pitbull in lipstick you will get funding (not that you need it) for your son or for friends of you and McCain that he paraded on national tv to get more of the sympathy votes and that to me is a shame)
"I never heard Governor Palin say as governor, `You have an advocate in Juneau,' " said Sonja Kerr, a lawyer specializing in disability law in Anchorage.
What lawyers, advocates and parents are seeking now, Ms. Kerr said, is to learn. "What is behind the announcement?" she said. "An advocate is someone who pleads another's cause, so what is her plea going to be? To get rid of Medicaid wait lists so we can get kids services? To quickly pass the American with Disabilities restoration act? That is what I haven't heard."
(And guess what you wont hear a thing either. See she dosent get it, just because you have a child with a special needs Sara that dont make you one of us and here is why. You can go to a specialist and get the best care, Were in regular folk like me have sigh up for Medical or Medicad or SSI and get treated like common criminals like we asked for this. We cant afford places like Dan Marino school, or other nice places but you can!!!. We cant walk into a dr office and just pull of 100 dollars for the visit, 100 dollars for test, 100 dollars for medication but wait you can. So tell me how you gonna advocate for me if you havent even been in my shoes? Umm sweetie you cant)
Alaska, both by dint of its sparse population and lack of resources, has often struggled to provide care and educational services for its roughly 18,000 children with physical and emotional disabilities.
For years the state shipped thousands of children out of state for mental health services, a problem so acute that Ms. Palin's predecessor created a program intended solely to get enough services in the state to bring the children back; from 2004 to 2007 the number of children sent out of state fell to 300 from about 600.
(wow you have go to be kidding me,)
While the state made a decision to close down mental health institutions in the 1990s, it has been unable to provide alternative services for children with mental health issues.
The rural makeup of the state outside Anchorage (where half the population resides) makes services all the more difficult.
"The reason they have so many problems is lack of resources," said Gary Mayerson, a lawyer who represents children with autism in 30 states. "We once went to Kodiak Island, where there are probably more bears than people, to see a kid with autism who needed a behavioral consultant. They literally have to fly these people in on float planes. So I can't exactly fault a school system for not having a speech therapist, but I do fault the district for not bringing them in or sending children out of the district for those resources."
Ms. Palin recently signed legislation that rewrote the state's school financing formulas, in the process dramatically increasing the budget for school districts that serve children with extreme special needs.
"She had no role whatsoever" in the development of the legislation, said its author, Representative Mike Hawker, a Republican. "Her role was signing. She recognized the importance of what we did and endorsed it."
(bull hockey she can have a voice, she can make suggestions to get these kids and parents what they needed. She was doing everything under the sun trying to bann books from library, getting folk fired, having affairs hell she had a lot of time on her hands that is a no brainer get er done)
Democrats have pointed, sometimes correctly, sometimes erroneously, to items in the state budget for the disabled that Ms. Palin cut.
According to state documents, she cut the state's Special Olympics budget in half.
The central concern of many parents with children who have special needs is the financing to fulfill the decades-old federal mandate requiring public schools to offer educational services to their children — or pay for them in nonpublic school settings.
The law, the Individuals with Disabilities Education Act, passed in 1975 with bipartisan support, called for the federal government to pick up 40 percent of the state cost of teaching children with special needs. The federal government pays less than half that, though more under the Bush administration than under President Clinton.
Mr. McCain voted to reauthorize the law, but voted against a measure, with nearly every other member of his party, to increase financing through a reduction in tax cuts for the wealthy. Mr. McCain has been a proponent of school vouchers, denounced by many advocates for children with special needs as draining public money away from special education programs; Ms. Palin is a school-choice advocate, her spokeswoman said.
Mr. McCain also opposes proposed federal legislation that would help pay for states to move people with special needs from state institutions into other living arrangements, but he has said he supports updating the Americans with Disabilities Act to offer more protections.
Ms. Comella, Ms. Palin's spokeswoman, would not elaborate on Ms. Palin's decision to make special needs children a centerpiece of her acceptance speech. But Ms. Palin's personal appeal held enormous emotional pull for parents who rarely see a public official who can personally identify with the same parental challenges as they do.
Ms. Palin's effort to rally parents of children with disabilities has also prompted reaction among those who fear that her idea of advocacy might really mean preventing abortions of fetuses with Down syndrome, rather than lobbying for the early medical and developmental assistance that is so crucial to their children's well-being.(B-I-N-G-O- YOU HIT THE NAIL ON THE HEAD)
New technology is enabling more women to learn in earlier stages of pregnancy whether their fetus is affected by Down syndrome. About 90 percent choose to terminate pregnancies. Parents of children with disabilities have sought to educate prospective parents on the emotional rewards of having children like their own. But many say they know better than anyone else how crucial it is that they be given a choice.
"Surely she understands that it can be dark and difficult sometimes," Sarahlynn Lester, whose daughter has Down syndrome, wrote on her blog this week about Ms. Palin. "Having been in the same position, I simply do not understand the desire to legislate (rather than educate) women into making better choices."
Nancy Iannone, a Democrat and mother of Gabrielle, 3, who has Down syndrome, said that she was so thrilled to see Trig on stage that she had to remind herself: "I am a liberal. I am a liberal. I am a liberal." Ms. Palin, she said, "has a child with a disability, but that doesn't mean her party is disability friendly."
(This is what you call dirty pool, you bring your son on stange to get that sympathy vote exploting your son like you are doing Bristol smh damn shame)
The last time a candidate explicitly appealed to families of the disabled at a national convention, advocates said, was 20 years ago, when the presidential nominee, George H. W. Bush, endorsed the Americans with Disabilities Act — and got a 10 percentage point bump among voters who identified themselves as having disabilities, according to Andrew Imparato, president of the American Association of People with Disabilities, a lobbying group.
On Thursday, Mr. Imparato said he and other advocates received an e-mail message from Senator Barack Obama's campaign outlining the disabilities issues that the Democrats had addressed at their convention.
"They certainly must be aware of the effect Palin is having on this community," Mr. Imparato said.
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Cramer, Niu to present classical concert at SLC
Christopher Cramer and Yi-Lan Niu will showcase their musical talents at a Classical Duo Concert, scheduled for 7 p.m. Oct. 11 at Silver Lake College.
Zimmer Forum spotlights 'The Centurion's Wife'
"The Centurion's Wife," written by Davis Bunn and Janette Oke, will be the focus of the next Fr. Bill Zimmer Forum, which is scheduled for noon to 1 p.m. on Oct. 14 at Silver Lake College, 2406 S. Alverno Road.
Weekly Silver Lake College sports roundup
SLC volleyball team beats NCAA DIII opponent
SLC Hosting CEO Breakfast Series
Silver Lake College announced the schedule of speakers for its inaugural 2014-2015 President's CEO Breakfast Series.
SLC, Woodland Dunes team up for Restore the Shore project
Migratory birds passing through the Lakeshore area will have new trees on which to rest thanks in part to the efforts of faculty and students at Silver Lake College in Manitowoc.
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SLC volleyball team wins UW-Richland Triangular
Silver Lake College Announces 9% Increase in Enrollment
Most private colleges throughout the state and nation are experiencing declining enrollment figures, but Silver Lake College is bucking that trend.
SLC announces 2014-2015 Mass schedule
Silver Lake College, 2406 S. Alverno Road, announced its schedule of Masses for the 2014-2015 academic year.


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7X05 The Angels Take Manhattan (Grading/Discussion) (SPOILERS!)
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October 9 2012, 05:28 PM
Bob The Skutter
Complete Arse Cleft
Location: Kernow
Re: 7X05 The Angels Take Manhattan (Grading/Discussion) (SPOILERS!)
The Mirrorball Man wrote:
Winnie The Pooh wrote:
Probably, but it's such a cop out. Basically it's just saying "
it only matters what the writer wants to do." which it is, but it also leads to unsatisfying stories. At least for me.
You can write time travel stories with a rigid set of rules, but you won't end up with anything that looks or feels like
Doctor Who
Don't need hard and fast rules, just this ending feels so unsatisfying when they've already had 3 decent jumping off points in their relationship with the Doctor that were more satisfying and just the week before they had another opportunity to call it a day in a way that would have left them in a good place without any of this convoluted nonsense.
Wisdom comes from experience. Experience is often a result of lack of wisdom.
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All hotels in Dyersburg, Tennessee, United States of America
1 room, 2 adults
2600 Lake Rd, Dyersburg, TN, 38024, United States of America, 855-238-1590
Days Inn Dyersburg
Lowest price$55
available on 07/08/15
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No-frills hotel in Dyersburg
- Free hot/cold buffet breakfast, free WiFi, and free parking
Main amenities
- 60 guestrooms
- 24-hour front desk
- Air conditioning
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Convenient location. A little older property, room was clean and bed comfortable so worth…
it wasn't bad but for just a few dollars more I could have way better
TripAdvisor Traveller Rating: 3.5
From 58 reviews
Enter dates to check prices
Hotel Info: 866-539-8117from $55
- Room, 1 Queen Bed, Smoking
- Standard Room, 2 Queen Beds, Smoking
- Standard Room, 1 Queen Bed
- Standard Room, 2 Queen Beds
- Standard Room, 1 King Bed, Smoking
- Standard Room, 1 King Bed
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Key facts
Hotel size
- This hotel has 60 rooms
- This hotel is arranged over 3 floors
- Check-in time starts at 3 PM
- Check-out time is 11 AM
Required at check in
- Credit card or cash deposit required
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Travelling with others
- Pets allowed *
- Up to 10 lb
- Free WiFi in public areas
- Free WiFi in rooms
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In the hotel
Food and drink
- Free hot/cold buffet breakfast daily
Things to do
- Free use of nearby fitness center
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Also known as
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Optional extras
Pets are allowed for an extra charge of USD 12.00 per pet, per night
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.


text: iOS quarterly downloads grew 30% between Q1 2014 and Q1 2015, meaning China surpassed the US and is now the world leader in iOS downloads, according to App Annie, a mobile analytics company headquartered in San Francisco. Danielle Levitas, senior vice president of App Annie, revealed the news at the Global Mobile Internet Conference (GMIC) in Beijing on Wednesday. Download growth translates into iOS App Store revenue gains. From Q1 2014 to Q1 2015, revenue in China grew 90% compared to 30% in the US and 50% in Japan. "China grew more quickly to narrow that gap," she said.


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"Same Day Music has an amazing selection at budget friendly prices. Every time i have had a question or issue with a product the men/women at Same Day Music are always very friendly and always help you every step of the way with determination and passion for not only the customer but for the product and for music." - Customer on May 14, 2015
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Heavy-duty guitar stand will last a long time and keep your axe out of harms way. >More
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The Ultimate Support GS-200 is part of the first series of guitar stands that deliver true innovation and musician-helpful features, the Genesis Series from Ultimate Support all offer a patented leg-locking system for stability, protective padding that won't inherently damage the finish on your guitar, and handy guitar pick storage slots. Whether you're looking for a quality stand for your acoustic, electric, or bass guitar, or even your favorite combo amp, there's a Genesis Series stand from Ultimate Support for you! >More
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Stagg SVEDB Electric Double Bass Stand
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On-Stage Heavy-Duty Triple Guitar Stand
Heavy-duty guitar stand will last a long time and keep your axe out of harms way. Note: Some assembly required. >More
RockStand by Warwick RS5 5-Guitar Stand
You can leave all those tripods at home and just bring one of these stable, folding stands to the gig! They're foam-padded so they'll never scratch your instrument and they hold acoustic or electric guitars and basses. This folding stand holds 5 guitars, so you can have room for every guitar you need and a couple backups. >More
Ultimate Support GS-1000 Guitar Stand
The Ultimate Support GS-1000 Genesis guitar stand is part of the first series of guitar stands that deliver true innovation and musician-helpful features, the Genesis Series from Ultimate Support all offer a patented leg-locking system for stability, protective padding that won't inherently damage the finish on your guitar, and handy guitar pick storage slots. >More
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Grundorf PRO-GSCG Guitar Stand Case
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The On-Stage GS7652B-Six guitar stand provides a great way to conserve valuable showroom or studio floor space by holding six guitars on just one folding tripod stand. The On-Stage GS7652B-Six guitar stand also features six folding back bumpers and a height adjustable center shaft. >More
The On-Stage GS7361 was built for gigs. It features a fold-and-go design to make your night easier. Simply fold the base and the stand packs neatly away with all of your other gear, so you go quickly from the stage to your car, truck, or van with ease. >More
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You can leave all those tripods at home and just bring one of these stable, folding stands to the gig! They're foam-padded so they'll never scratch your instrument and they hold acoustic or electric guitars and basses. This model holds up to 3 guitars or basses, so you have room for every guitar you use in a show. >More
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On-Stage GS7253B-B Duo Flip-It Stand
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OnStage WGS100 Single Wood Guitar Stand
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On-Stage Heavy-Duty Double Guitar Stand
Heavy-duty guitar stand will last a long time and keep your axe out of harms way. >More
OnStage GS7355 Triple Hang Guitar Stand
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Fender Universal A Frame Guitar Stand
Fender's Universal A-Frame Stand for electric guitars and basses is the first of its kind, designed to hold not only offset instruments such as the Fender Jazz Bass and Jazzmaster guitar, but also instruments with more extreme shapes such as the Jackson Rhoads and Kelly models. >More
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String Swing BCC151NFW Guitar Holder
Displays your instrument horizontally! Fully adjustable for right-handed or left-handed guitars! 1-piece unit allows for easier mounting. Narrow model that fits electric guitars up to 2 3/4". Works for left and right handed guitars and basses. Comes with all mounting hardware. >More
On-Stage GS7353B-B Tri Flip-It Stand
The On-Stage GS7353B-B features the same design as GS7153B, but holds any combination of guitars, basses and banjos. All the same great features as the Duo Flip -It!(r), but designed to support three guitars on one stand. >More
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ABSTRACT: The 29th annual meeting of the Society for Immunotherapy of Cancer (SITC) was held November 7-9, 2014 in National Harbor, MD and was organized by Dr. Arthur A. Hurwitz (National Cancer Institute), Dr. Kim A. Margolin (Stanford University), Dr. Daniel E. Speiser (Ludwig Center for Cancer Research, University of Lausanne) and Dr. Walter J. Urba (Earle A. Chiles Research Institute, Providence Cancer Center). This meeting included over 1,600 registered participants from 28 separate countries, making it the largest SITC meeting held to date. It highlighted significant worldwide progress in the development and application of cancer immunology to the practice of clinical oncology, including advances in diagnosis, prognosis and therapy, utilizing several immunological pathways and mechanisms for a variety of oncologic conditions. Presentations and posters demonstrated that many concepts that had been pursued preclinically in the past are now being translated into clinical practice, with clear benefits for patients.05/2015; 3(1). DOI:10.1186/s40425-015-0062-4
Article: Abstract P5-01-12: Breast specific gamma imaging (BSGI) and breast magnetic resonance imaging (MRI): Comparison of sensitivity and specificity in women prior to breast biopsy with BIRADS 4 or 5 finding on mammography in a community settingCancer Research 05/2015; 75(9 Supplement):P5-01-12-P5-01-12. DOI:10.1158/1538-7445.SABCS14-P5-01-12 · 9.28 Impact Factor
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ABSTRACT: The concept of using immunotherapy to treat melanoma has existed for decades. The rationale comes from the knowledge that many patients with melanoma have endogenous immune responses against their tumor cells and clinically meaningful tumor regression can be achieved in a minority of patients using cytokines such as interleukin-2 and adoptive cellular therapy. In the last 5 years there has been a revolution in the clinical management of melanoma in large measure based on the development of antibodies that influence T cell regulatory pathways by overcoming checkpoint inhibition and providing co-stimulation, either of which results in significantly more effective immune-mediated tumor destruction. This review will describe the pre-clinical and clinical application of antagonistic antibodies targeting the T-cell checkpoints cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed death 1 (PD-1), and agonistic antibodies targeting the costimulatory pathways OX40 and 4-1BB. Recent progress and opportunities for future investigation of combination antibody therapy will be described. Copyright © 2015 Elsevier Ltd. All rights reserved.Molecular Immunology 03/2015; DOI:10.1016/j.molimm.2015.01.025 · 3.00 Impact Factor
Article: Efficacy and Safety of Nivolumab in Patients With BRAF V600 Mutant and BRAF Wild-Type Advanced Melanoma: A Pooled Analysis of 4 Clinical Trials[Show abstract] [Hide abstract]
ABSTRACT: Importance The anti-PD-1 therapeutic antibody, nivolumab, has demonstrated clinical activity in patients with advanced melanoma. The activity of nivolumab in subgroups of patients with tumors which have wild-type BRAF kinase vs patients with tumors having mutant BRAF has not systematically been explored in a large dataset. Objective To evaluate the efficacy and safety of nivolumab in patients with wild-type BRAF and mutant BRAF metastatic melanoma. Design, Setting, and Participants This was a retrospective analysis of data pooled from 4 clinical trials of nivolumab in 440 adult patients with unresectable stage III or stage IV melanoma, who had been tested for BRAF mutational status while participating in one of the studies.Intervention The investigational drug, nivolumab, was administered intravenously to study participants over a 60-minute period, at doses of 0.1, 0.3, 1.0, 3.0, or 10.0 mg/kg every 2 weeks until disease progression, discontinuation owing to adverse events, withdrawal, or end of study. Most patients (83%) received nivolumab at a dosage of 3 mg/kg. Main Outcome and Measure Best overall response by modified World Health Organization or Response Evaluation Criteria In Solid Tumors criteria and safety profile. Results Of a total of 440 patients from 4 nivolumab clinical trials included in the analysis, 334 were BRAF wild-type and 106 were positive for BRAF V600 mutation. With the exception of prior BRAF inhibitor therapy, the demographics were well balanced between the 2 cohorts. In patients evaluable for response, the objective response rates were 34.6% (95% CI, 28.3-41.3) for the 217 patients with wild-type BRAF status and 29.7% (95% CI, 19.7-41.5) for the 74 with mutant BRAF status. The objective response rates did not seem to be affected by prior BRAF inhibitor therapy, prior ipilimumab therapy, or PD-L1 status of the tumor. The median duration of objective response was 14.8 months (95% CI, 11.1-24.0 months) for wild-type BRAF and 11.2 months (95% CI, 7.3-22.9 months) for mutant BRAF. Median time to objective response was 2.2 months in both patient groups. The incidence of treatment-related adverse events of any grade was 68.3% in the wild-type BRAF group and 58.5% in the mutant BRAF group, with grade 3 or 4 adverse events in 11.7% and 2.8% of patients, respectively. Treatment-related AEs of any grade that occurred in at least 5% of patients in either group were fatigue, pruritus, rash, and diarrhea.Conclusions and Relevance The results of this retrospective analysis suggest that nivolumab has similar efficacy and safety outcomes in patients with wild-type or mutant BRAF, regardless of prior BRAF inhibitor or ipilimumab treatment.01/2015; DOI:10.1001/jamaoncol.2015.1184
Article: Durable responses and reversible toxicity of high-dose interleukin-2 treatment of melanoma and renal cancer in a Community Hospital Biotherapy Program[Show abstract] [Hide abstract]
ABSTRACT: High-dose interleukin-2 (IL-2) has been FDA-approved for over 20 years, but it is offered only at a small number of centers with expertise in its administration. We analyzed the outcomes of patients receiving high-dose IL-2 in relation to the severity of toxicity to ascertain if response or survival were adversely affected.05/2014; 2:13. DOI:10.1186/2051-1426-2-13
Article: Cross-presentation of viral antigens in dribbles leads to efficient activation of virus-specific human memory t cells[Show abstract] [Hide abstract]
ABSTRACT: Autophagy regulates innate and adaptive immune responses to pathogens and tumors. We have reported that autophagosomes derived from tumor cells after proteasome inhibition, DRibbles (Defective ribosomal products in blebs), were excellent sources of antigens for efficient cross priming of tumor-specific CD8+ T cells, which mediated regression of established tumors in mice. But the activity of DRibbles in human has not been reported. DRibbles or cell lysates derived from HEK293T or UbiLT3 cell lines expressing cytomegalovirus (CMV) pp65 protein or transfected with a plasmid encoding dominant HLA-A2 restricted CMV, Epstein-Barr virus (EBV), and Influenza (Flu) epitopes (CEF) were loaded onto human monocytes or PBMCs and the response of human CMV pp65 or CEF antigen-specific CD4+ and CD8+ memory T cells was detected by intracellular staining. The effect of cytokines (GM-CSF, IL-4, IL-12, TNF-alpha, IFN-alpha and IFN-gamma) TLR agonists (Lipopolysaccharide, Polyinosinic-polycytidylic acid (poly(I:C), M52-CpG, R848, TLR2 ligand) and CD40 ligand on the cross-presentation of antigens contained in DRibbles or cell lysates was explored . In this study we showed that purified monocytes, or human PBMCs, loaded with DRibbles isolated from cells expressing CMV or CEF epitopes, could activate CMV- or CEF-specific memory T cells. DRibbles were significantly more efficient at stimulating CD8+ memory T cells compared to cell lysates expressing the same antigenic epitopes. We optimized the conditions for T-cell activation and IFN-gamma production following direct loading of DRibbles onto PBMCs. We found that the addition of Poly(I:C), CD40 ligand, and GM-CSF to the PBMCs together with DRibbles significantly increased the level of CD8+ T cell responses. DRibbles containing specific viral antigens are an efficient ex vivo activator of human antigen-specific memory T cells specific for those antigens. This function could be enhanced by combining with Poly(I:C), CD40 ligand, and GM-CSF. This study provides proof-of-concept for applying this strategy to activate memory T cells against other antigens, including tumor-specific T cells ex vivo for immunological monitoring and adoptive immunotherapy, and in vivo as vaccines for patients with cancer.Journal of Translational Medicine 04/2014; 12(1):100. DOI:10.1186/1479-5876-12-100 · 3.99 Impact Factor
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ABSTRACT: The cellular and molecular principles that furnish the foundation for ACT of melanoma and their implications for further clinical research are reviewed. The parallel advances in basic immunology, preclinical animal studies, and clinical trials over the last two decades have been integrated successfully with improvements in technology to produce an effective ACT strategy for patients with melanoma. From the initial observation that tumors could be treated effectively by the transfer of immune cells to current strategies using preconditioning with myeloablative therapy before adoptive transfer of native or genetically altered T cells, the role of preclinical animal models is discussed. The importance of the pmel transgenic mouse model in the determination of the mechanisms of lymphodepletion, the ongoing work to identify the optimal T cells for adoptive immunotherapy, and the early impact of the emerging discipline of synthetic biology are highlighted. The clinical consequences of the research described herein are reviewed in the companion manuscript.Journal of leukocyte biology 03/2014; 95(6). DOI:10.1189/jlb.0513301 · 4.99 Impact Factor
- 11/2013; 1(Suppl 1):P113-P113. DOI:10.1186/2051-1426-1-S1-P113
Article: DPV-001 an autophagosome-enriched cancer vaccine in phase II clinical trials contains 25 putative cancer antigens, DAMPS, HSPS and agonists for TLR 2, 3, 4, 7 and 911/2013; 1(Suppl 1):P260-P260. DOI:10.1186/2051-1426-1-S1-P260
Article: Developing an immunotherapy strategy for the effective treatment of patients with squamous cell carcinoma of the head and neck11/2013; 1(Suppl 1):P262. DOI:10.1186/2051-1426-1-S1-P262
Article: A Phase II Study of Bevacizumab and High-dose Interleukin-2 in Patients With Metastatic Renal Cell Carcinoma: A Cytokine Working Group (CWG) Study[Show abstract] [Hide abstract]
ABSTRACT: Overexpression of vascular endothelial growth factor in renal cell carcinoma (RCC) leads to angiogenesis, tumor progression, and inhibition of immune function. We conducted the first phase II study to estimate the efficacy and safety of bevacizumab with high-dose interleukin-2 (IL-2) therapy in patients with metastatic RCC. Eligible patients had predominantly clear cell metastatic RCC, measurable disease, a Karnofsky Performance Status of ≥80%, and adequate end-organ function. IL-2 (600,000 IU/kg) was infused intravenously every 8 hours (maximum 28 doses) during two 5-day cycles on days 1 and 15 of each 84-day course. Bevacizumab (10 mg/kg) was infused intravenously every 2 weeks beginning 2 weeks before initiating IL-2. Fifty of 51 eligible patients from 8 centers were enrolled. Median progression-free survival (PFS) was 11.2 months (90% confidence interval, 5.7-17.7), and 2-year PFS was 18% (90% confidence interval, 8%-27%). Responses included 4 complete (8%) and 11 partial (22%) responses. Toxicities did not exceed those expected from each agent alone. Combining IL-2 plus bevacizumab is feasible, with a response rate and PFS at least as high as reported previously for the single agents. The regimen did not appear to enhance the rate of durable major responses over that of IL-2 alone.Journal of immunotherapy (Hagerstown, Md.: 1997) 11/2013; 36(9):490-5. DOI:10.1097/CJI.0000000000000003 · 3.35 Impact Factor
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ABSTRACT: OX40 is a potent co-stimulatory receptor that can potentiate T cell receptor signaling on the surface of T lymphocytes, leading to their activation by a specifically recognized antigen. In particular, OX40 engagement by ligands present on dendritic cells dramatically increases the proliferation, effector function and survival of T cells. Preclinical studies have shown that OX40 agonists increase anti-tumor immunity and improve tumor-free survival. In this study, we performed a Phase I clinical trial using a mouse monoclonal antibody (mAb) that agonizes human OX40 signaling in patients with advanced cancer. Patients treated with one course of the anti-OX40 mAb showed an acceptable toxicity profile and regression of at least one metastatic lesion in 12/30 patients. Mechanistically, this treatment increased T and B cell responses to reporter antigen immunizations, led to preferential upregulation of OX40 on CD4+ FoxP3+ regulatory T cells in tumor-infiltrating lymphocytes andincreased the anti-tumor reactivity of T and B cells in patients with melanoma. Our findings clinically validate OX40 as a potent immune-stimulating target for treatment in cancer patients, providing a generalizable tool to favorably influence the antitumor properties of circulating T cells, B cells and intratumoral regulatory T cells.Cancer Research 10/2013; 73(24). DOI:10.1158/0008-5472.CAN-12-4174 · 9.28 Impact Factor
Article: The Society for Immunotherapy of Cancer consensus statement on tumour immunotherapy for the treatment of cutaneous melanoma.[Show abstract] [Hide abstract]
ABSTRACT: Immunotherapy is associated with durable clinical benefit in patients with melanoma. The goal of this article is to provide evidence-based consensus recommendations for the use of immunotherapy in the clinical management of patients with high-risk and advanced-stage melanoma in the USA. To achieve this goal, the Society for Immunotherapy of Cancer sponsored a panel of melanoma experts-including physicians, nurses, and patient advocates-to develop a consensus for the clinical application of tumour immunotherapy for patients with melanoma. The Institute of Medicine clinical practice guidelines were used as a basis for this consensus development. A systematic literature search was performed for high-impact studies in English between 1992 and 2012 and was supplemented as appropriate by the panel. This consensus report focuses on issues related to patient selection, toxicity management, clinical end points and sequencing or combination of therapy. The literature review and consensus panel voting and discussion were used to generate recommendations for the use of immunotherapy in patients with melanoma, and to assess and rate the strength of the supporting evidence. From the peer-reviewed literature the consensus panel identified a role for interferon-α2b, pegylated-interferon-α2b, interleukin-2 (IL-2) and ipilimumab in the clinical management of melanoma. Expert recommendations for how to incorporate these agents into the therapeutic approach to melanoma are provided in this consensus statement. Tumour immunotherapy is a useful therapeutic strategy in the management of patients with melanoma and evidence-based consensus recommendations for clinical integration are provided and will be updated as warranted.Nature Reviews Clinical Oncology 08/2013; DOI:10.1038/nrclinonc.2013.153 · 15.70 Impact Factor
- The Oncologist 06/2013; 18(6):658-60. DOI:10.1634/theoncologist.2013-0212 · 4.54 Impact Factor
Article: Development of ipilimumab: a novel immunotherapeutic approach for the treatment of advanced melanoma[Show abstract] [Hide abstract]
ABSTRACT: The immunotherapeutic agent ipilimumab has helped address a significant unmet need in the treatment of advanced melanoma. Ipilimumab is a fully human monoclonal antibody that targets cytotoxic T-lymphocyte antigen-4 (CTLA-4), thereby augmenting antitumor immune responses. After decades in which a number of clinical trials were conducted, ipilimumab was the first therapy to improve overall survival in a randomized, controlled phase III trial of patients with advanced melanoma. These results led to the regulatory approval of ipilimumab at 3 mg/kg for the treatment of unresectable or metastatic melanoma. More than 17,000 patients worldwide have received ipilimumab, either as a commercial drug at 3 mg/kg or in clinical trials and expanded access programs at different doses. Consistent with its proposed mechanism of action, the most common toxicities associated with ipilimumab therapy are inflammatory in nature. These immune-related adverse events were mostly reversible when effective treatment guidelines were followed. Importantly, long-term follow-up of patients who received ipilimumab in a phase III trial showed that 24% survived at least two years, and in phase II studies, a proportion of patients survived at least five years. Evaluation of ipilimumab is ongoing in the adjuvant setting for melanoma, and for advanced disease in nonsmall cell lung, small cell lung, prostate, ovarian, and gastric cancers.Annals of the New York Academy of Sciences 06/2013; 1291(1). DOI:10.1111/nyas.12180 · 4.31 Impact Factor
Article: The additional facet of immunoscore: immunoprofiling as a possible predictive tool for cancer treatment[Show abstract] [Hide abstract]
ABSTRACT: Recent investigations of the tumor microenvironment have shown that many tumors are infiltrated by inflammatory and lymphocytic cells. Increasing evidence suggests that the number, type and location of these tumor-infiltrating lymphocytes in primary tumors has prognostic value, and this has led to the development of an 'immunoscore' As well as providing useful prognostic information, the immunoscore concept also has the potential to help predict response to treatment, thereby improving decision- making with regard to choice of therapy. This predictive aspect of the tumor microenvironment forms the basis for the concept of immunoprofiling, which can be described as 'using an individual's immune system signature (or profile) to predict that patient's response to therapy. The immunoprofile of an individual can be genetically determined or tumor-induced (and therefore dynamic). Ipilimumab is the first in a series of immunomodulating antibodies and has been shown to be associated with improved overall survival in patients with advanced melanoma. Other immunotherapies in development include anti-programmed death 1 protein (nivolumab), anti-PD-ligand 1, anti-CD137 (urelumab), and anti-OX40. Biomarkers that can be used as predictive factors for these treatments have not yet been clinically validated. However, there is already evidence that the tumor microenvironment can have a predictive role, with clinical activity of ipilimumab related to high baseline expression of the immune-related genes FoxP3 and indoleamine 2,3-dioxygenase and an increase in tumor-infiltrating lymphocytes. These biomarkers could represent the first potential proposal for an immunoprofiling panel in patients for whom anti-CTLA-4 therapy is being considered, although prospective data are required. In conclusion, the evaluation of systemic and local immunological biomarkers could offer useful prognostic information and facilitate clinical decision making. The challenge will be to identify the individual immunoprofile of each patient and the consequent choice of optimal therapy or combination of therapies to be used.Journal of Translational Medicine 03/2013; 11(1):54. DOI:10.1186/1479-5876-11-54 · 3.99 Impact Factor
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ABSTRACT: Anticancer immunotherapy holds great promises, as long-term responses to interleukin-2 have been observed in metastatic melanoma and renal cell carcinoma patients. However, improving the relative low rates of such responses has constituted a great challenge. In our experience, high-dose radiation combined with interleukin-2 provided encouraging results that are worth exploring further.OncoImmunology 12/2012; 1(9):1645-1647. DOI:10.4161/onci.21746 · 6.28 Impact Factor
- 10/2012; 2(10):957-959. DOI:10.4155/cli.12.101
Article: An open-label, phase 2 trial of RPI.4610 (Angiozyme) in the treatment of metastatic breast cancer.[Show abstract] [Hide abstract]
ABSTRACT: Serum and plasma levels of vascular endothelial growth factor (VEGF) correlate with prognosis in patients with metastatic breast cancer (MBC). VEGF binds to 2 receptors on endothelial cells, VEGFR-1 and VEGFR-2. RPI.4610 (Angiozyme0) is an antiangiogenic ribozyme targeting the VEGFR-1 mRNA. Preclinical and phase 1 studies suggested that RPI.4610 is a well-tolerated agent with clinical activity in solid tumors. The authors' trial evaluated the efficacy of RPI.4610 in the treatment of patients with progressive MBC. This phase 2, multicenter, single-arm study was designed to assess the objective response rate of RPI.4610 in patients with MBC who had experienced disease progression with at least 1 course of chemotherapy for MBC. Patients received daily subcutaneous injections of RPI.4610 100 mg/m(2) for 12 weeks. Most patients (93%) had received at least 2 lines of chemotherapy previously; 69% of patients had received at least 3 lines of chemotherapy. Median follow-up was 2.76 months (range, 0.89-36.6 months). No partial responses nor complete responses were found. Median progression-free survival was 1.41 months (95% confidence interval [CI], 1.35-1.45). The median overall survival from start of treatment was 11.89 months (95% CI, 4.11-23.66). Treatment-related adverse events (AEs) were primarily grade 1 to 2 in intensity. Most common AEs were: injection site reactions, abdominal pain, anorexia, chromaturia, constipation, dyspnea, fatigue, headache, pain at the injection site, nausea, vomiting, and fever. Although RPI.4610 demonstrated a well-tolerated safety profile, its lack of clinical efficacy precludes this drug from further development.Cancer 09/2012; 118(17):4098-104. DOI:10.1002/cncr.26730 · 4.90 Impact Factor
Article: Autophagy-assisted antigen cross-presentation Autophagosome as the argo of shared tumor-specific antigens and DAMPs[Show abstract] [Hide abstract]
ABSTRACT: It is generally believed that most tumor antigens are passively released from either health or dying tumor cells as intact soluble antigens, peptide fragments complexed with heat shock proteins (HSPs), or packaged in secretary vesicles in the form of microparticles or exosomes. The passive release of tumor antigens is generally non-inflammatory and non-immunogenic; however, results from others and our laboratories suggest that autophagy is critically involved in immunogenic cell death.OncoImmunology 09/2012; 1(6):976-978. DOI:10.4161/onci.20059 · 6.28 Impact Factor
Top Journals
Providence Portland Medical CenterPortland, Oregon, United States
Rush University Medical CenterChicago, Illinois, United States
Oregon Research InstituteEugene, Oregon, United States
Dana-Farber Cancer InstituteBoston, Massachusetts, United States
Northern California Arthritis CenterWalnut Creek, California, United States
Loyola University Chicago
Chicago, IL, United States
- Cardinal Bernardin Cancer Center
Beth Israel Deaconess Medical Center
Boston, MA, United States
- Division of Hematology/Oncology
Oregon Health and Science University
Portland, Oregon, United States
- Department of Molecular Microbiology & Immunology
National Institutes of HealthMaryland, United States
Leidos Biomedical ResearchMaryland, United States
National Cancer Institute (USA)
Maryland, United States
- Cancer Therapy Evaluation Program
SAICUnited States
Frederick Memorial HospitalФредерик, Maryland, United States
NCI-FrederickФредерик, Maryland, United States


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This property allows you to book online with a credit card. After submitting a reservation request, the owner or manager has 24 hours to accept, at which time your card will be charged and you will receive an email confirmation
Recent Mount Rainier reviews
"Three Bears Coho cabin at was perfect for our family getaway this year. The bunkhouse was just what we needed to house our oldest son who was home from college for the weekend with girlfriend in tow. And being that the cabin is dog friendly, we didn't have to pay the steep dog sitting fees that typically come when we actually manage to get the whole family together for a vacation. The interior of the main cabin is well kept, warm and relaxing but the outside deck with the dining table and chairs was my favorite feature. Morning coffee as the sun was coming up, the sounds of nature at lunchtime, dinner at sunset — there's nothing quite like eating together outdoors. This vacation was just what our family needed. Everything provided to keep it low stress, enough space to accommodate everyone's personal needs, cozy enough to bring us together. An experience I hope to have again and again."Guest: Rbuckman Date of Stay: September 2014 Review Submitted: January 24, 2015View listing
"Everything was exactly as the description said. The cabin was super clean, well stocked with everything we needed and very well maintained. The owner was prompt with a response and she was happy to accommodate our few special requests. I would definitely recommend this cabin to friends and family."Guest: Eric G. Date of Stay: May 2015 Review Submitted: May 18, 2015View listing
"The River House was clean, well equipped and in an awesome setting. We enjoyed listening to the river in the background and sitting in the hot tub while viewing the mountain surroundings. We think that we even had a glimpse of the peak of Mount Rainier from the backyard. The neighbors are not too close and there's plenty of woods between the properties so that you have privacy. The Nisqually entrance to Mount Rainier National Park is only a few minutes away. We had been concerned about finding places to eat in the area because it is extremely rural but there were plenty to choose from and 2 small grocery stores too. We were very pleased with our choice to stay at The River House and would definitely recommend it to others!"Guest: Amanda H. Date of Stay: June 2015 Review Submitted: June 21, 2015View listing
"Had a great time at this cabin. Especially appreciated the grassy yard/clearing where the kids could run around a bit. Also like being able to walk down to the General Store for any last-minute groceries, etc. We will be back!"Guest: Mountain Goat Date of Stay: February 2015 Review Submitted: February 19, 2015View listing
Featured Destinations: Yosemite Cabins, Lake Nacimiento, Lake Tahoe Cabin Rentals, Lake Almanor


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Stayed at Elephants Eye Lodge for 3 nights over New Year and found it to be a lovely h.omeaway from home. The rooms are very large, well equiped and everything was clean and tidy with comfortable beds and linen as well as being very well serviced daily. The location is good for exploring most of Cape Town with easy access... More
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Last night I went out with some freinds to the bar around my way. But before then I stopped by Robs house to see what he was up to and if he had any other plans. He was babysitting his neice who was over for the night while her mommy was out getting waisted. I met his brother-in-law whos also an avid gamer. Me and him clicked instantly. I got his gamertag as well as an invite to his clan on Xbox live.
Afterwards me Brad and Rob went to the Hazzlwood Inn and gotten a couple of drinks. And I saw one of my old high school freinds a few hours later. She broguht one of her other freinds who looked pretty cute. The girls name is Christine. We hit it off pretty well she invited me to a pary thats happening tonight. So I guess I'll try to work my magic tonight also


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30304 EsperanzaRancho Santa Margarita, CA 92688
Licensed for 28 years
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- AG's, comptroller's offices to meet in court Tuesday
- Comptroller: state payroll system antiquated
- Remember, fireworks are dangerous
- Wallace asks citizens to fight cuts
- Dispute over state payroll rolls on
- Why fight over free trade confounds partisan divide
- Still no state budget
- Crime control is not the responsibility of landlords
- Fly over to the Poplar Grove Wings and Wheels Museum benefit
- Local leaders warn of budget deadlock's impact
NIHGC makes changes to staff, board of directors
A promotion and staff and board additions took place throughout the summer at Northern Illinois Hospice and Grief Center (NIHGC).
NIHGC named Lisa Novak as executive director effective July 1. Novak, who served as the agency's development director prior to her promotion, replaces Carol A. Bennett, who retired after 10 years with the agency.
Three community members were named to the Board of Directors in July, including: Kathy Lundy, longtime NIHGC patient volunteer and human resource manager at Chem Processing, Inc.; Scott Olson, vice president of Olson Funeral & Cremation Services, Ltd.; and Matt Dargene, commercial relationship manager with U.S. Bank.
Staff additions include admission nurse Tara Shale, RN, BSN, who brings to the agency 20 years of nursing experience, with three years in a hospice environment, and PRN nurse Juliette Strombeck, RN, CBN, BSN, who has 14 years of nursing experience and is enrolled in the Family Nurse Practitioner Program at Saint Anthony College of Nursing.
From the Sept. 19-25, 2012, issue


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Hydroponic Systems
Hydroponic Grow Lights & Bulbs
Hydroponic Tents & Grow Boxes
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Grow Light Reflectors
Hydroponic Nutrients
Grow Media Rocks
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Hydroponic Seeds
Hydroponic Foggers
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This Kirby Morgan KMB-10 was my backup band mask thatI usedfive times in the clean fresh water of the Great Lakes since it was completely redone in 2004.With no expense spared spending over $1,600.00 on new parts back then. It sat on the book shelf displayed proudly in my home office. It must go now since I no longer dive.
I used it last in November 2010 and worked great.
Includescomplete working KMB-10 Band Mask,Kirby Morgan tool kit,Kirby Morgan storage bag, spare spider (used but good), spare hood / with newer face seal (used but good),paperwork and more paperwork (exploded diagram, parts list cross reference guide, assembly instructions, product bulletins.
You can use this or put on a self and display it. Also includes a waterproof high use connector for the comms as well as the bannana plugs mic and speakers work great. Has the updated High Flow Auxiliary Emergency Valve and new SuperFlow regulator assembly. The original "US Divers"regulator is included but is missing parts.
Why spend money on a new KMB-18 or KMB-28.
If you have any questions just ask.
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Kit Of Scuba Diving


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Have enjoyed a variety of events, all of which have been enjoyable. From Forum lecture series to theatre productions to educational classes - all have been worthwhile.
We really enjoyed this show. Strong performers in a small theater on Sanibel Island where every seat is close to the stage. Kudos!
The Monday night films are a regular activity for us. Get there early. It fills quickly for most movies.
Sanibel is so fortunate that the "movers and shakers" on the Island saw fit to organize a BigArts Center that brings all manner of culture to our little piece of paradise. There is a very full calender of events available so that music lovers of all sorts are satisfied with concerts in every type of music...jazz, classical, contemporary, country, folk....
Convenient mid-island location directly on Periwinkle Place. Grounds are pristine. We toured 2 art shows and viewed the outdoor sculptures. Bought a few pieces of jewelry - hand made and affordable! Staff is very friendly and informative. There is a theater on the property with many types of shows. Location of Sunday morning farmer's market - best ever!
We went to a concert at Big Arts and it was nice because it is a small venue and you could see well and hear well regardless of where you sat. The seating is not pre assigned. During the intermission they had free wine and cookies and walking around the lovely grounds at night was a plus. I would go...
We enjoyed several activities presented by BIG ARTS on a trip to Sanibel. We attended a free jazz concert on a Sunday afternoon (bring your own chair if you have one). The music was good and the atmosphere was friendly and fun. We also toured an exhibit in the gallery and purchased tickets for plays at the theatre. Check to...
I was very anxious to see the art galleries here, but was disappointed when I got there. While this is the main gallery on the island, there wasn't much too it. The facility provides an outlet for performing arts as well as visual arts, and their line-up for performing artists was impressive. Unfortunately, not of them were appearing during our...
Who would expect a cultural center in vacationland. Apparently the local folk really appreciate listening and learning. We attended a movie that was something out of the arts theater venue. It was a full house and the crow was mostly locals.
We went to a jazz concert at this lovely venue and thoroughly enjoyed the program. The people were friendly and other members of the audience were happy to mingle and chat. It was nice vacation entertainment.
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Prezzo - Amersham
3 Whielden Street, Amersham, HP7 0HT +44 1494958268
- Average
- Main course: £9
- Food spend: £17
- Opening hours
- Monday to Saturday: 12:00 - 23:30 Sunday: 12:00 - 23:00.
Excellent meal! Lovely atmosphere + a free bottle of Prosecco for my husbands birthday!
Michelle Kerr
07 April 2015
from Chesham
Buy a dining gift at your favourite Prezzo restaurant…
3 courses & a glass of wine, £30 for 2 people
3 courses & a bottle of prosecco, £55 for 2 people
In the market town of Amersham, Prezzo Italian restaurant offers diners a wide variety of Italian dishes. In a traditional white fronted building, Prezzo's modern interior has a relaxing atmosphere.
The Prezzo menu presents a range of exciting dishes, crafted according to the season's best ingredients. Sample freshly-grilled flatbread salads topped with veggie-friendly bella lodi cheese, or wild mushroom-loaded pasta, pizza and risotto. All the favourite antipasti dishes are on offer, as well as speciality folded calzones.
Start your visit with a fruity, fizzy pre-dinner aperitivo from the Prezzo cocktail list, and finish with indulgent desserts like tiramisu, panna cotta, and chocolate hazelnut cheesecake.
Amersham Prezzo is a 2-minute walk from Amersham Museum, and is served by multiple bus stops.
Prezzo - Amersham
3 Whielden Street, Amersham, HP7 0HT
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Customer reviews for Prezzo - Amersham
- Food
- Value
- Ambience
- Location
- Service
- Drinks
((((( 7 April 2015 by Michelle Kerr from Chesham
Excellent meal! Lovely atmosphere + a free bottle of Prosecco for my husbands birthday!
(((** 19 July 2014 by Janet Fegan from High Wycombe
Not a great evening really. We were brought our main courses before our starters, the starter was a bread board to share, but there wasn't much for the price. The main courses were fine but trying to pay at the end was a bit of a nightmare. We got the bill and then had to ask several times to be able to pay, which took a further 20 minutes. It turned out that they only had one card machine for the whole restaurant.
((((( 19 May 2014 by Karl Symes from Bourne End
We were we'll look after, the starter we had a bread board, I had the crab cakes which were bait over done but very tasty, my wife had for main chicken ravioli and censer salad which she thought excellent, I had king prawn spaghetti bolognese which was one of the best I have ever had out side of Italy , the sweets I had lovely terimisue and my wife had the hazel nut Boone which we both enjoyed,
The food and service were both very good, it has good disabled access , our only criticism is there is no on site parking which would make it difficult for wheelchair users .
((*** 19 February 2014 by Lizzieday Day from Amersham
The food wasn't impressive and service was slow. The waiter didn't know what an aubergine was?!
((((* 18 February 2014 by Des Lee from Amersham
Just minor details, if you are asked if you want something , before your starter , I think you should get it, ! Not tell the waiter don't bother as we have our starter now, there should of been a complementary drink or something given without the customer asking, just a gesture of good will, will make customers go back
((((( 16 February 2014 by Trudy Pringle from Amersham
Lovely staff and lovely food! Would recommend to everyone.
((((* 14 February 2014 by Tina Casey from Hayes
Hospitable, professional and really enjoyed the evening and service.
((((( 14 December 2013 by Karen Bowman from Amershm
Three of us had a very good meal. Good service. Good value for money. Only downside is lack of parking at the restaurant. We parked in the pay and display car park 5-10 mins walk away.
((((* 23 November 2013 by Barbara Bennett from St Albans
Good food with plenty of choices. Enjoyed the risotto and friends enjoyed the crab cakes. Staff pleasant and helpful. Will definitely go there again.
((((* 24 August 2013 by Jackie from Hazlemere
Used our taste card so got 2 4 1 on starter, main and desert so very cheap eve out. It was good weather so we sat outside which was lovely. Good service. Nicely presented food. Have been before and always good
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POLAND: CEDC sells Polish distribution arm
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WD Re (WD4000FYYZ) 4TB Enterprise HDD Review
The WD Re (WD4000FYYZ) comes in both 6Gb/s and 3Gb/s SATA and SAS flavors in a 7,200 RPM 3.5" form factor. The Re is geared for heavy workload environments in the datacenter, including RAID arrays, external storage arrays, data warehousing and data mining operations. The WD Re comes in a multitude of capacities, including 250GB, 500GB and the larger capacities, which weigh in from 1TB to 4TB's.
The RE fits in the middle of the WD datacenter product stack, with the Xe and Se bookends delivering different levels of service. The Xe provides the ultimate in performance with a SAS interface and 10,000 RPM's on tap. The Se is a 7,200 RPM HDD for less demanding workloads, delivering the incrementally lower performance via a SATA connection. The Re, or RAID Edition, HDD features higher resilience and performance than the Se in spite of the utilizing the same 7,200 RPM spindle speed.
HDD failures are a constant reality in the datacenter, and with some datacenters supporting tens of thousands of servers per location, and some housing far more, this constant stream of failures requires intense micromanagement. Workers spend countless man-hours replacing failed drives, and RAID rebuild periods strangle server performance and bring the threat of downtime. Once removed, failed drives are typically physically destroyed to protect customer or company data, adding yet another layer of expenditure to an already expensive process.
The Re brings a mix of different features that combine to deliver the higher speed and durability required in datacenter applications with heavy write workloads. The Re is designed to handle up to 550TB per year. The inclusion of a SAS interface also widens the spectrum of capabilities for the Re series. The SAS interface provides HA (High Availability) full duplex features, such as failover and multipath, and the robust SAS feature set.
The higher reliability of the Re, which features an MTBF of 1.2 million hours, helps to reduce the never-ending drive replacement cycle. While high-capacity drives from the competition also offer impressive MTBF specifications, the Re really distances itself from the competition with an industry leading 10E16 non-recoverable read errors per bits read. This is a 100x improvement over other drives with a 10E15 rating.
The Re also features a dual-core processor, with twice the processing power to boost performance. The SATA version features a healthy 64MB of cache, while the SAS version utilizes 32MB of cache. This combination combines to deliver up to 171 MB/s of sequential throughput for SATA, and 182 MB/s for the SAS version.
RAID-specific time-limited error recovery (TLER) prevents the drive from dropping in a RAID array due to an extended hard drive error-recovery. Dual actuator technology provides precise placement of the head over data tracks, while StableTrac secures both ends of the motor shaft to reduce vibration in multi-drive deployments. The WD Re series also has SED offerings with AES 256-bit encryption and Crypto Erase functionality for users with more stringent security demands. The SED drives support the T13 Sanitize command and the ATA Password support of Secure Erase Unit (SEU).
Reliability is key, and WD subjects their enterprise drives to at least five million hours of functional testing, and over 20 million hours of interoperability testing. Each individual drive also experiences an extended burn-in with thermal cycling to ensure reliability. The intense qualification and testing leads to a five-year warranty for the Re series of drives.
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|By Marketwired .
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|January 23, 2013 07:04 PM EST
SAN DIEGO, CA -- (Marketwire) -- 01/23/13 --
-Kasey Kahne, driver of the No. 5 Farmers Insurance Chevrolet for Hendrick Motorsports
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A beautiful $35,000 Chevrolet Camaro from Hendrickcars.com will be given away by Kasey Kahne to winner Roger Dietterle. It's the culmination of the Farmers Insurance Start Your Engines Sweepstakes that launched Sept. 17, 2012 via the Farmers Racing Facebook page.
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Posted 12 October 2012 - 19:31
Maybe the writers are actually serious about this...
yeah but no Punk makes me wonder?
According to F4WOnline.com, The Undertaker is expected to work a high profile match at WrestleMania 29, and his potential opponents are currently being discussed, with one possibility being CM Punk ending the streak and "earning everyone's respect."
Contrary to what WWE normally does with The Undertaker, the company is considering bringing The Dead Man back for the Royal Rumble PPV in January, and possibly having him win the Royal Rumble match.
The feeling is an Undertaker Royal Rumble win along with a title shot at WrestleMania 29 could bring in a strong buy rate for the big PPV.
Posted 12 October 2012 - 19:36
Yeah, if Rock-Cena 2 happens, you can bet your ass Cena is going to win that one. Even Rock would wonder what's up with Vince if he wants to put Rocky over Cena. It just makes zero sense for a 2nd time (it made no sense for the 1st time either).