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ABSTRACT: Introduction: We investigated the 2-year survival rate and incidence of spontaneous tumors in F344/DuCrlCrlj rats used in carcinogenicity studies of chemical substances. Records for animals used in the control groups of carcinogenicity studies which were conducted during the last 10 years were obtained from the database of the Japan Bioassay Research Center (JBRC). Six hundred ninety-nine males and 550 females were used in 14 and 11 inhalation studies, respectively, and 500 animals of each sex were used in 10 male and 10 female oral studies. Methods: In each study, SPF (specific pathogen free) animals were housed for 2 years (104 weeks) as control groups in the carcinogenicity studies. All animals underwent necropsy and histopathological examination. Each study was conducted in accordance with the Good Laboratory Practice. Results: The incidence of interstitial cell tumors was highest in both inhalation studies and oral studies (inhalation studies 86.1%, oral studies 68.6%). Tumors which had an incidence of 6% or higher were adenoma of the pituitary, C-cell adenoma of the thyroid, and mononuclear cell leukemia (LGL leukemia) of the spleen in male and female rats; fibroma of the subcutaneous tissue, adrenal pheochromocytoma, and islet cell adenoma of the pancreas in male rats; and endometrial stromal polyps and fibroadenoma of the mammary gland in female rats. Tumors other than the above had rare incidence rates. A clear difference in the incidence of spontaneous tumors was not observed between the inhalation and oral studies. The incidences of spontaneous tumors in control groups of previous oral studies are similar to our findings. There are no other reports of the spontaneous tumor incidence in the control groups of inhalation studies using F344/DuCrlCrlj rats. The 2-year survival rate was about 77% in both the inhalation and oral studies, and a gender difference was not observed. The F344/DuCrlCrlj rats used at JBRC had a higher 2-year survival rate than F344/N rats. This difference is possibly due to the low incidence of LGL leukemia in the F344/DuCrlCrlj rat. Conclusions: The incidences of spontaneous tumors in F344/DuCrlCrlj rats used in control groups of both inhalation and oral studies during the last 10 years at JBRC are similar to each other and similar to those reported in other studies. This is the first report on the incidence of spontaneous tumors in inhalation studies and contributes to the toxicological evaluation of studies using F344/DuCrlCrlj rats.SANGYO EISEIGAKU ZASSHI 03/2015; DOI:10.1539/sangyoeisei.E14006
Article: Vascular endothelial growth factor mRNA levels as a biomarker for short-term N-butyl-N-(4-hydroxybutyl) nitrosamine-induced rat bladder carcinogenesis bioassay[Show abstract] [Hide abstract]
ABSTRACT: Generically, carcinogenic effects of chemicals in bladder carcinogenesis are judged by induction of papillary or nodular (PN) hyperplasia in rats given N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) for 4 weeks and the test chemical for 22–28 weeks. However, upregulation of vascular endothelial growth factor (VEGF) begins early in rat BBN bladder carcinogenesis. To establish a short-term rat bladder carcinogenic bioassay, we analyzed the correlations between VEGF, VEGF mRNA and bladder lesions inductions at 10 and 26 weeks after BBN treatment. Six-week-old male Wistar (slc) rats were given 0.05% BBN for 4, 10 or 26 weeks. To avoid individual rat bias, the bladders were investigated by partial cystectomy at 10 weeks and total cystectomy at 26 weeks. After induction, PN hyperplasia and carcinoma in rats increased with the length of BBN treatment and immunohistochemical VEGF expression also increased following carcinogenesis, but the immunoreactivity of individual lesions was quite variable. Moreover, induction of PN hyperplasia at 10 weeks' BBN treatment was not significantly correlated with that at 26 weeks' treatment; thus, it was not possible to predict the carcinogenic effect due to the induction of PN hyperplasia at 26 weeks' BBN treatment by that at 10 weeks' treatment. However, VEGF mRNA levels of rat bladders at 10 weeks' BBN treatment revealed a strong significant correlation with the incidence of bladder lesions at 26 weeks' treatment. Here, we suggest that quantitative VEGF mRNA levels are a good biomarker for a short-term BBN-induced bioassay for rat bladder carcinogenesis. Copyright © 2014 John Wiley & Sons, Ltd.Journal of Applied Toxicology 02/2015; 35(2). DOI:10.1002/jat.3021 · 3.17 Impact Factor
Article: Quantitative evaluation of the pulmonary microdistribution of TiO 2 nanoparticles using X-ray fluorescence microscopy after intratracheal administration with a microsprayer in rats: Pulmonary microdistribution of T i O 2 NP s[Show abstract] [Hide abstract]
ABSTRACT: The unevenness of pulmonary nanoparticle (NP) distribution, which hinders the establishment of an absolute dose–response relationship, has been described as one of the limitations of intratracheal administration techniques for toxicological assessment of inhaled NPs. Quantification of the NP microdistribution would facilitate the establishment of a concentration–response relationship in localized regions of the lung; however, such quantitative methods have not been reported. Here, we established a quantitative method for evaluating pulmonary TiO2 NP microdistribution in rats using X-ray fluorescence microscopy. Ti intensity in lung sections from rats intratracheally administered 10 mg kg–1 TiO2 NPs with a microsprayer was measured using X-ray fluorescence with a 100 µm beam size. Ti reference samples were prepared by dropping different concentrations of Ti solutions on glass slide or lung sections of untreated rat. Ti intensity increased linearly with Ti content in the reference samples on both substrates. The detection limit of TiO2 was estimated to be 6.3 ng mm–2. The reproducibility was confirmed for measurements done in the short- (2 weeks) and long-term (6 months). The quantitative results of TiO2 NP microdistribution suggested that more TiO2 NPs were distributed in the right caudal and accessory lobes, which are located downstream of the administration direction of the NP suspension, and the lower portion of each lobe. The detection rates of TiO2 NPs were 16.6–25.0%, 5.19–15.6%, 28.6–39.2%, 21.4–38.7% and 10.6–23.2% for lung sections from the right cranial, middle, caudal, accessory and left lobes, respectively. Copyright © 2015 John Wiley & Sons, Ltd.Journal of Applied Toxicology 01/2015; 35(6). DOI:10.1002/jat.3109 · 3.17 Impact Factor
Article: Valerian Inhibits Rat Hepatocarcinogenesis by Activating GABA(A) Receptor-Mediated Signaling.[Show abstract] [Hide abstract]
ABSTRACT: Valerian is widely used as a traditional medicine to improve the quality of sleep due to interaction of several active components with the γ-aminobutyric acid (GABA) A receptor (GABA(A)R) system. Recently, activation of GABA signaling in stem cells has been reported to suppress cell cycle progression in vivo. Furthermore, possible inhibitory effects of GABA(A)R agonists on hepatocarcinogenesis have been reported. The present study was performed to investigate modulating effects of Valerian on hepatocarcinogenesis using a medium-term rat liver bioassay. Male F344 rats were treated with one of the most powerful Valerian species (Valeriana sitchensis) at doses of 0, 50, 500 and 5000 ppm in their drinking water after initiation of hepatocarcinogenesis with diethylnitrosamine (DEN). Formation of glutathione S-transferase placental form positive (GST-P+) foci was significantly inhibited by Valerian at all applied doses compared with DEN initiation control rats. Generation of 8-hydroxy-2'-deoxyguanosine in the rat liver was significantly suppressed by all doses of Valerian, likely due to suppression of Nrf2, CYP7A1 and induction of catalase expression. Cell proliferation was significantly inhibited, while apoptosis was induced in areas of GST-P+ foci of Valerian groups associated with suppression of c-myc, Mafb, cyclin D1 and induction of p21Waf1/Cip1, p53 and Bax mRNA expression. Interestingly, expression of the GABA(A)R alpha 1 subunit was observed in GST-P+ foci of DEN control rats, with significant elevation associated with Valerian treatment. These results indicate that Valerian exhibits inhibitory effects on rat hepatocarcinogenesis by inhibiting oxidative DNA damage, suppressing cell proliferation and inducing apoptosis in GST-P+ foci by activating GABA(A)R-mediated signaling.PLoS ONE 11/2014; 9(11):e113610. DOI:10.1371/journal.pone.0113610 · 3.53 Impact Factor
Article: Inhalation exposure to 1,2-dichloropropane: Distribution of blood and tissue concentrations of 1,2-dichloropropane in rats during and after exposure.[Show abstract] [Hide abstract]
ABSTRACT: The present investigation was undertaken to determine the distribution and accumulation of 1,2-dichloropropane (DCP) in the blood, lung, liver, kidney, and abdominal fat of rats during and after inhalation exposure. Male rats were exposed to 80 or 500 ppm (v/v) DCP vapor for 360 min and the concentrations of DCP in the blood and tissues during the inhalation exposure period and after the end of the exposure period were measured. DCP accumulation in the abdominal fat was much greater than that in the blood and other tissues. Eighteen hours after the end of inhalation exposure, DCP could still be detected in the abdominal fat in the 80-ppm group, and in the blood, liver, kidney, and abdominal fat in the 500-ppm group. Our results are valuable data pertaining to the pharmacokinetics of DCP and to human health risk assessment of exposure to DCP vapor by inhalation.Journal of Environmental Science and Health Part A Toxic/Hazardous Substances & Environmental Engineering 10/2014; 49(12):1341-8. DOI:10.1080/10934529.2014.928193 · 1.14 Impact Factor
Article: The increases in relative mRNA expressions of inflammatory cytokines and chemokines in splenic macrophages from rats exposed to multi-walled carbon nanotubes by whole-body inhalation for 13 weeks[Show abstract] [Hide abstract]
ABSTRACT: Abstract Background: The toxicity of multi-walled carbon nanotubes (MWCNT) may be related to the immune system. The objective of this study was to obtain information for immunotoxic mechanisms of MWCNT in situ. Methods: Using whole-body inhalation, male and female rats were exposed to 0, 0.2, 1 or 5 mg MWCNT/m(3) for 13 weeks. Thereafter, spleens were recovered from the rats. Real-time PCR was done to assess expression of TNFα, IL-1β, IL-6, IL-10, MCP-1 and MIP-1α mRNA in the splenic macrophages; splenic T-lymphocytes were examined for IL-2 and TGF-β1 mRNA expression. Results: The relative expression of IL-1β mRNA in the cells from female rats exposed to 5 mg MWCNT/m(3) was significantly higher than that in control cells. For IL-6 and IL-10, cells from rats in the 0.2 and 5 mg MWCNT/m(3) had significantly higher mRNA expressions than did cells from controls. Expression of IL-1β, IL-6 and TNFα genes in cells from males in all exposure groups were higher than in control cells. Expression of MIP-1α in the cells from female 5-mg group was significantly higher than that in cells in the control. Only IL-2 was expression reduced, i.e. cells from male and female rats in all MWCNT groups had significantly lower mRNA expressions than control cells. Conclusions: Systemic inflammation would likely occur in rats (or other hosts) exposed to MWCNT via inhalation due to increases in the expression of inflammatory cytokines in splenic macrophages. Moreover, decreases in IL-2 expression in T-lymphocytes may be critical to the potential reductions in anti-tumor responses in MWCNT-exposed hosts.Inhalation Toxicology 10/2014; 26(12):750-758. DOI:10.3109/08958378.2014.953275 · 2.34 Impact Factor
Article: Thirteen-week study of toxicity of fiber-like multi-walled carbon nanotubes with whole-body inhalation exposure in rats[Show abstract] [Hide abstract]
ABSTRACT: Abstract Cancer development due to fiber-like straight type of multi-walled carbon nanotubes (MWCNTs) has raised concerns for human safety because of its shape similar to asbestos. To set concentrations of MWCNT for a rat carcinogenicity study, we conducted a 13-week whole body inhalation study. F344 male and female rats, 6-week-old at the commencement of the study, were exposed by whole-body inhalation to MWCNT at concentrations of 0, 0.2, 1 and 5 mg/m(3) with a generation and exposure system utilizing the cyclone sieve method. Measured concentrations in the exposure chambers were 0.20 ± 0.02, 1.01 ± 0.11 and 5.02 ± 0.25 mg/m(3) for 13 weeks. The MMAD (GSD) of MWCNT were 1.4-1.6 μm (2.3-3.0), and mean width and length were 94.1-98.0 nm and 5.53-6.19 μm, respectively, for each target concentration. Lung weights were increased 1.2-fold with 1 mg/m(3) and 1.3-fold with 5 mg/m(3) in both sexes compared to the controls. In the bronchoalveolar lavage fluid (BALF) analyses, inflammatory parameters were increased concentration-dependently in both sexes from 0.2 mg/m(3). Granulomatous changes in the lung were induced at 1 and 5 mg/m(3) in females and even at 0.2 mg/m(3) in males. Focal fibrosis of the alveolar wall was observed in both sexes at 1 mg/m(3) or higher. Inflammatory infiltration in the visceral pleural and subpleural areas was induced only at 5 mg/m(3). In conclusion, we determined 0.2 mg/m(3) as the low-observed-adverse-effect level (LOAEL) for respiratory tract toxicity in the present inhalation exposure study of rats.Nanotoxicology 07/2014; 9(4):1-10. DOI:10.3109/17435390.2014.933903 · 7.34 Impact Factor
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ABSTRACT: Harderian gland tumors are extremely rare in female F344 rats. An expansive enlarging lesion of the Harderian gland with compression, distortion and invasion of the surrounding muscle was found in a 110-week-old female F344/DuCrj rat, which was diagnosed as a Harderian gland adenocarcinoma. Epithelial growth patterns such as glandular, lobular, papillary and duct forming patterns were exhibited in most areas of the tumor. The tumor cells were pleomorphic and atypical. In one part of the tumor, poorly differentiated areas were found. This case was observed in the middle dose group of a carcinogenicity study of diphenylamine, which was not carcinogenic, we determine to be this case was a spontaneous tumor.Journal of Toxicologic Pathology 07/2014; 27(2):139-42. DOI:10.1293/tox.2013-0066 · 0.94 Impact Factor
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ABSTRACT: The carcinogenicity of inhaled dichloromethane (DCM) was examined by exposing groups of 50 F344/DuCrj rats and 50 Crj: BDF1 mice of both sexes to 0, 1000, 2000, or 4000 ppm (w/w) DCM-containing aerosol for 2 years. Inhalation of DCM resulted in increased incidences of subcutis fibromas, mammary gland fibroadenoma, and peritoneum mesotheliomas in male rats; mammary gland fibroadenomas in female rats; and bronchiolar–alveolar adenomas and carcinomas in the lung and hepatocellular adenomas and carcinomas in male and female mice. These results clearly indicate that inhaled DCM is carcinogenic in F344/DuCrj (SPF) rats and Crj: BDF1 (SPF) mice.Inhalation Toxicology 06/2014; 26(8). DOI:10.3109/08958378.2014.905660 · 2.34 Impact Factor
Article: Cleistocalyx nervosum Extract Ameliorates Chemical-Induced Oxidative Stress in Early Stages of Rat Hepatocarcinogenesis[Show abstract] [Hide abstract]
ABSTRACT: Purpose: To study the effect of Cleistocalyx nervosum extract (CE) on diethylnitrosamine (DEN) and phenobarbital (PB) induced oxidative stress in early stages of rat hepatocarcinogenesis. Materials and Methods: Male Wistar rats were divided into 4 groups, with Group 1 as a negative control and Group 2 was a positive control receiving DEN injections once a week and PB in drinking water for 6 weeks. Two weeks before DEN initiation and PB treatment, Groups 3 and 4, were fed with 500 and 1000 mg/kg of CEs, respectively, for 8 weeks. Results: A number of GST-P-positive foci, preneoplastic lesions, in the liver were markedly increased in carcinogen administered rats, but was comparatively decreased in rats treated with 1000 mg/kg of CE. The CE reduced malondialdehyde in serum and in the livers of rats treated with DEN and PB. Moreover, CE significantly increased the activities of glutathione peroxidase and catalase in rat liver. Conclusions: CE appeared to exert its chemopreventive effects by modulating antioxidant status during DEN and PB induced early stages of hepatocarcinogenesis in rats.Asian Pacific journal of cancer prevention: APJCP 03/2014; 15(6):2825-30. DOI:10.7314/APJCP.2014.15.6.2825 · 2.51 Impact Factor
Article: Estimation of chloroform inhalation dose by other routes based on the relationship of area under the blood concentration-time curve (AUC)-inhalation dose to chloroform distribution in the blood of rats[Show abstract] [Hide abstract]
ABSTRACT: The present study investigated the time-course changes of concentration of chloroform (CHCl3) in the blood during and after exposure of male rats to CHCl3 by inhalation. Increasing the dose of CHCl3 in the inhalation exposed groups caused a commensurate increase in the concentration of CHCl3 in the blood and the area under the blood concentration-time curve (AUC). There was good correlation (r = 0.988) between the inhalation dose and the AUC/kg body weight. Based on the AUC/kg body weight-inhalation dose curve and the AUC/kg body weight after oral administration, inhalation equivalent doses of orally administered CHCl3 were calculated. Calculation of inhalation equivalent doses allows the body burden due to CHCl3 by inhalation exposure and oral exposure to be directly compared. This type of comparison facilitates risk assessment in humans exposed to CHCl3 by different routes. Our results indicate that when calculating inhalation equivalent doses of CHCl3, it is critical to include the AUC from the exposure period in addition to the AUC after the end of the exposure period. Thus, studies which measure the concentration of volatile organic compounds in the blood during the inhalation exposure period are crucial. The data reported here makes an important contribution to the physiologically based pharmacokinetic (PBPK) database of CHCl3 in rodents.Journal of Environmental Science and Health Part A Toxic/Hazardous Substances & Environmental Engineering 02/2014; 49(3):253-61. DOI:10.1080/10934529.2014.846191 · 1.14 Impact Factor
Article: Induction of cell proliferation in the rat liver by the short-term administration of ethyl tertiary-butyl ether[Show abstract] [Hide abstract]
ABSTRACT: In the present study, in continuation of our previous experiment in order to investigate the mode of action (MOA) of ethyl tertiary-butyl ether (ETBE) hepatotumorigenicity in rats, we aimed to examine alterations in cell proliferation, that are induced by short-term administration of ETBE. F344 rats were administered ETBE at doses of 0, and 1,000 mg/kg body weight twice a day by gavage for 3, 10, 17 and 28 days. It was found that the previously observed significant increase of P450 total content and hydroxyl radical levels after 7 days of ETBE administration, and 8-OHdG formation at day 14, accompanied by accumulation of CYP2B1/2B2, CYP3A1/3A2, CYP2C6, CYP2E1 and CYP1A1 and downregulation of DNA oxoguanine glycosylase 1, was preceded by induction of cell proliferation at day 3. Furthermore, we observed an increase in regenerative cell proliferation as a result of ETBE treatment at day 28, followed by induction of cell cycle arrest and apoptosis by day 14. These results indicated that short-term administration of ETBE led to a significant early increase in cell proliferation activity associated with induction of oxidative stress, and to a regenerative cell proliferation as an adaptive response, which could contribute to the hepatotumorigenicity of ETBE in rats.Journal of Toxicologic Pathology 01/2014; 28(1). DOI:10.1293/tox.2014-0056 · 0.94 Impact Factor
Article: No Promoting Effect of Ethyl Tertiary-butyl Ether (ETBE) on Rat Urinary Bladder Carcinogenesis Initiated with N-Butyl-N-(4-hydroxybutyl)nitrosamine[Show abstract] [Hide abstract]
ABSTRACT: The effects of ethyl tertiary-butyl ether (ETBE) on two-stage urinary bladder carcinogenesis in male F344 rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) were investigated at various dose levels with regard to possible promoting activity. Groups of 30 rats were given drinking water containing 500 ppm BBN, as an initiator, for 4 weeks and starting one week thereafter received ETBE by gavage (daily, 7 days/week) at dose levels of 0 (control), 100, 300, 500 or 1000 mg/kg/day until experimental week 36. No statistically significant differences in incidences of preneoplastic lesions, papillomas, and carcinomas of the urinary bladder were evident in rats treated with 100-1000 mg/kg/day ETBE as compared with control values. Furthermore, the average numbers of preneoplastic or neoplastic lesions per unit length of basement membrane in rats given 100-1000 mg/kg/day ETBE were also comparable to control values. However, papillomatosis of the urinary bladder was found in 4 out of 30 rats (13%) in the group given 1000 mg/kg/day ETBE, and soft stones in the urinary bladder were found in 3 out of these 4 rats. The results thus demonstrated that ETBE did not exert promotional activity on urinary bladder carcinogenesis. However, papillomatosis of the urinary bladder developed in small numbers of the rats given ETBE at 1000 mg/kg/day but not in rats given 500 mg/kg/day or lower doses.Journal of Toxicologic Pathology 12/2013; 26(4):351-7. DOI:10.1293/tox.2013-0027 · 0.94 Impact Factor
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ABSTRACT: This review highlights several in vivo studies utilizing non-genotoxic and genotoxic chemical carcinogens, and the mechanisms of their high and low dose carcinogenicities with respect to formation of oxidative stress. Here, we survey the examples and discuss possible mechanisms of hormetic effects with cytochrome P450 inducers, such as phenobarbital, a-benzene hexachloride and 1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane. Epigenetic processes differentially can be affected by agents that impinge on oxidative DNA damage, repair, apoptosis, cell proliferation, intracellular communication and cell signaling. Non-genotoxic carcinogens may target nuclear receptors and induce post-translational modifications at the protein level, thereby impacting on the stability or activity of key regulatory proteins, including oncoproteins and tumor suppressor proteins. We further discuss role of oxidative stress focusing on the low dose carcinogenicities of several genotoxic carcinogens such as a hepatocarcinogen contained in seared fish and meat, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, arsenic and its metabolites, and the kidney carcinogen potassium bromate.12/2013; 5(4):1332-54. DOI:10.3390/cancers5041332
Article: Mode of action of ethyl tertiary-butyl ether hepatotumorigenicity in the rat: Evidence for a role of oxidative stress via activation of CAR, PXR and PPAR signaling pathways[Show abstract] [Hide abstract]
ABSTRACT: To elucidate possible mode of action (MOA) and human relevance of hepatotumorigenicity in rats for ethyl tertiary-butyl ether (ETBE), male F344 rats were administered ETBE at doses of 0, 150 and 1000 mg/kg body weight twice a day by gavage for 1 and 2 weeks. For comparison, non-genotoxic carcinogen phenobarbital (PB) was applied at a dose of 500 ppm in diet. Significant increase of P450 total content and hydroxyl radical levels by low, high doses of ETBE and PB treatments at weeks 1 and 2, and 8-OHdG formation at week 2, accompanied accumulation of CYP2B1/2B2, CYP3A1/3A2 and CYP2C6, and downregulation of DNA oxoguanine glycosylase 1, induction of apoptosis and cell cycle arrest in hepatocytes, respectively. Up-regulation of CYP2E1 and CYP1A1 at weeks 1 and 2, and peroxisome proliferation at week 2 were found in high dose ETBE group. Results of proteome analysis predicted activation of upstream regulators of gene expression altered by ETBE including constitutive androstane receptor (CAR), pregnane-X-receptor (PXR) and peroxisome proliferator-activated receptors (PPARs). These results indicate that the MOA of ETBE hepatotumorigenicity in rats may be related to induction of oxidative stress, 8-OHdG formation, subsequent cell cycle arrest, and apoptosis, suggesting regenerative cell proliferation after week 2, predominantly via activation of CAR and PXR nuclear receptors by a mechanism similar to that of PB, and differentially by activation of PPARs. The MOA for ETBE hepatotumorigenicity in rats is unlikely to be relevant to humans.Toxicology and Applied Pharmacology 12/2013; 273(2):390–400. DOI:10.1016/j.taap.2013.09.016 · 3.63 Impact Factor
Article: Novel method using hybrid markers: development of an approach for pulmonary measurement of multi-walled carbon nanotubes.[Show abstract] [Hide abstract]
ABSTRACT: Multi-walled carbon nanotubes (MWCNT)s are suspected to induce pulmonary and pleural cancers due to their asbestos-like configurations. Therefore, accurate measurement of inhaled nanotubes in target organs is crucial for assessing cancer risk. Conventionally, nanotubes are measured after combustion at high temperature for conversion into CO2; however, the sensitivity is poor and the method lacks versatility. We have therefore developed a novel approach using hybrid markers for nanotube analysis, featuring high sensitivity and the capacity to conduct repeated analyses. The method involves adsorption of markers to nanotubes, followed by their desorption and assessment by means of high performance liquid chromatography (HPLC). Recovery of MWCNT from rat lungs was conducted, and pulmonary MWCNT amounts were determined using rats intratracheally-exposed to MWCNT aerosol at 5 mg/m3 for 6 hours/day. The correlation coefficient for the calibration curve of MWCNT weight and the HPLC area was 0.9991. Consequently, the lower quantitation limit yielded was 0.2 mug. The recovery was 92-98% at approximately 0.4-2.0 mug demonstrating that MWCNTs in the lung could be measured accurately and precisely. We have developed a novel method using a hybrid marker approach for nanotube analysis, featuring very high sensitivity and the capacity to conduct repeated analyses. We further confirmed correlations between the amounts of nanotubes and markers and pulmonary nanotube measurement demonstrated that trace amounts could be detected with values closely relating to the administered dose, verifying that the method is sensitive and precise.Journal of Occupational Medicine and Toxicology 10/2013; 8(1):30. DOI:10.1186/1745-6673-8-30 · 1.23 Impact Factor
Article: Distribution of blood and tissue concentrations in rats by inhalation exposure to 1,2-dichloroethane[Show abstract] [Hide abstract]
ABSTRACT: The compound 1,2-dichloroethane (DCE) is a ubiquitous environmental contaminant. The primary route of exposure of humans to DCE is inhalation of its vapor. The present investigation was undertaken to determine the distribution and accumulation of DCE in the blood, lung, liver, brain, kidney and abdominal fat of rats during and after inhalation exposure. Male rats were exposed to 160 ppm (v/v) of DCE vapor for 360 min and the concentrations of DCE in the blood and tissues during the inhalation exposure period and after the end of the exposure period were measured. DCE accumulation in the abdominal fat was much greater than that in the blood and other tissues. The information we obtained in this study is useful basic data pertaining to the pharmacokinetics of DCE and DCE-mediated carcinogenicity: Our results suggest that one of the factors involved in the induction of peritoneal tumors in rats exposed to DCE vapor by inhalation is DCE accumulation in the abdominal fat.Journal of Environmental Science and Health Part A Toxic/Hazardous Substances & Environmental Engineering 07/2013; 48(9):1031-6. DOI:10.1080/10934529.2013.773765 · 1.14 Impact Factor
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ABSTRACT: Abstract The subchronic toxicity and carcinogenicity of 1,2-dichloropropane (DCP) in male and female B6D2F1 mice exposed to DCP by inhalation for 13 weeks or for 2 years was investigated. The DCP concentrations used were 50, 100, 200, 300 or 400 ppm (v/v) in the 13-week study, and 32, 80 or 200 ppm (v/v) in the 2-year study. Thirteen weeks inhalation exposure of mice to DCP caused death in the mice exposed to 300 ppm and above, and was found to induce hemolytic anemia and lesions of the liver, forestomach and heart. Two years exposure to DCP significantly increased the combined incidence of bronchiolo-alveolar adenomas and carcinomas in females and marginally increased the incidence of Harderian gland adenomas in males. As non-neoplastic lesion, atrophy and respiratory metaplasia in the olfactory epithelium, and respiratory metaplasia in the submucosal gland of the nasal cavity were increased. Thus, two years inhalation exposure to DCP is carcinogenic in female mice and there is a marginal evidence of carcinogenicity in males.Inhalation Toxicology 07/2013; DOI:10.3109/08958378.2013.800618 · 2.34 Impact Factor
Article: Two-week Toxicity of Multi-walled Carbon Nanotubes by Whole-body Inhalation Exposure in Rats[Show abstract] [Hide abstract]
ABSTRACT: To evaluate pulmonary toxicity of multi-walled carbon nanotubes (MWCNTs), F344 rats of both sexes were exposed by inhalation to 0.2, 1 or 5 mg/m(3) MWCNT aerosol for 6 h/day, 5 days/week for 2 weeks using a whole-body exposure system. At the end of the 2-week exposure period, one-half of the rats were necropsied, and at the end of an additional 4-week postexposure period, the remaining rats were necropsied. MWCNTs were deposited in the lungs of all MWCNT-exposed groups and mostly remained in the lungs throughout the 4-week postexposure period. Granulomatous changes in the lung were found in the rats exposed to 5 mg/m(3) MWCNTs, and these changes were slightly aggravated at the end of the 4-week postexposure period. In the bronchoalveolar lavage fluid (BALF), the numbers of neutrophils, percentages of bi- and multinucleated alveolar macrophages, levels of ALP activity and concentrations of total protein and albumin were elevated in the rats exposed to 1 and 5 mg/m(3) MWCNTs. At the end of the 4-week postexposure period, the values of the BALF parameters tended to remain elevated. In addition, goblet cell hyperplasias in the nasal cavity and nasopharynx were observed in the rats exposed to 1 and 5 mg/m(3) MWCNTs, but these lesions had largely regressed by the end of the postexposure period. Based on the histopathological and inflammatory changes, the no-observed-adverse-effect level (NOAEL) for inhalation of MWCNTs for 2 weeks was 0.2 mg/m(3).Journal of Toxicologic Pathology 06/2013; 26(2):131-40. DOI:10.1293/tox.26.131 · 0.94 Impact Factor
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ABSTRACT: Abstract Carcinogenicity of 1,1,1-trichloroethane (TCE) was examined by an inhalation exposure of F344 rats and BDF1 mice of both sexes to TCE at 0, 200, 800 or 3200 ppm for 6 h/d, 5 d/week for 104 weeks. In male rats, the incidences of bronchiolo-alveolar adenomas and peritoneal mesotheliomas were significantly increased in the 800 and 3200 ppm-exposed groups, respectively. The incidence of bronchiolo-alveolar adenomas in the 3200 ppm-exposed groups exceeded the range of historical control data in the Japan Bioassay Research Center. In female rats, the tumor incidences were not increased in any organs of the TCE-exposed groups. In male mice, a significant positive trend with dose was shown for incidences of bronchiolo-alveolar carcinomas, combined incidences of bronchiolo-alveolar adenomas/carcinomas and hepatocellular adenomas. The incidence of Harderian gland adenomas was significantly increased in the 3200 ppm-exposed group, and malignant lymphomas of spleen at this highest dose exceeded the range of historical control data. In female mice, the combined incidence of bronchiolo-alveolar adenomas/carcinomas was significantly increased in the 3200 ppm-exposed group, and the incidences of hepatocellular adenomas and combined incidences of hepatocellular adenomas/carcinomas were significantly increased in the 200, 800 and 3200 ppm-exposed groups with dose dependence except the combined incidence of hepatocellular adenomas/carcinomas in the 200 ppm-exposed group. The incidences of bronchiolo-alveolar adenomas in the 3200 ppm-exposed group and combined incidences of hepatocellular adenomas/carcinomas in the 200 ppm-exposed groups exceeded the ranges of historical control data. Thus, this study provided clear evidence of inhalation carcinogenicity for TCE in both rats and mice.Inhalation Toxicology 04/2013; 25(5):298-306. DOI:10.3109/08958378.2013.780116 · 2.34 Impact Factor
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I worked at Life Care Centers full-time (Less than a year)
The facility is clean and updated, they are nationally recognized, they have a good benefit plan for full-time employees
Training was a joke (3 days - even for newly graduated CNAs and nurses), no teamwork even though it's emphasized in orientation a great deal, constant favoritism by managers, terrible staffing, many residents had bed sores because they were not turned every 2 hours as required by state regulations
Advice to Management
Stop floating extra CNAs to other halls and make sure there are enough CNAs to residents so that CNAs don't have to juggle 12 residents at a time! There was never enough time to get patients ready for the day when you multiply 12 patients times 15 minutes per patient and get 2 hours. We only got 1 hour and 15 minutes to get residents ready. If there was 6 residents to 1 CNA, there would be WAY more time to get everything done. Also, don't allow double standards among managers. If a rule is applied to one employee, it should be applied to everyone - regardless of employment longevity.
- Any Location
- Any Job Title
- Any Status
I worked at Life Care Centers full-time (More than a year)Doesn't RecommendApproves of CEODoesn't RecommendApproves of CEO
one 3 day weekend every four weeks
Rotating Work schedule isn't great
Helpful (1)
I worked at Life Care Centers
Improving quality of life for elderly and educational benefits don't count on the rest of benefits cause corporate will not come through
Budget does not reflect new dining standards and bottom dollar first residents last
Advice to Management
Policy and procedures not upgraded to present day requirements. Upper management should talk to head office and give staff tools needed to be successful.

subset: commoncrawl


text:
Mandy Moore
Singer + Actress
Born Apr 10, 1984 Age 31
Hometown Nashua, New Hamps... Net Worth $22 Million
Religion Other Genres Rock music + Danc...
Record Label RED, LLC Height 5' 9" (177 cm)
Amanda Leigh "Mandy" Moore is an American singer–songwriter, actress and fashion designer. Raised in Florida, Moore first came to prominence with her 1999 debut single "Candy", which peaked at number 41 on the Billboard Hot 100. Its subsequent album,… Read More
View newly released photos of Mandy Moore.
Check out the latest love interests for Mandy Moore.
Ryan AdamsMarried 2009 - Present
Greg LaswellDated 2007
Adam GoldsteinDated 2007
Zach BraffDated 2004 - 2006
Andy RoddickDated 2002 - 2004
Billy CrawfordDated 2002
Wilmer ValderramaDated 2001 - 2002
Brian McFaydenDated 2001 - 2002
Discover the family history of Mandy Moore.
Mandy Moore
Age 31
Stacy MooreFather
Don MooreFather
Scott MooreBrother
Kyle MooreBrother
News + Updates
Browse recent news and stories about Mandy Moore.
Beth Whaanga's Powerful Breast Cancer Portraits Lost Her 100 Friends, But Could Save Many More LivesThe Huffington Post - Feb 14, 2014
Field Service Technician Fire AlarmChicago Times - Feb 08, 2014
10 Movie Proposals That Will Tug At Your HeartstringsHuffington Post - Nov 30, 2013
Learn about the memorable moments in the evolution of Mandy Moore.
1984 Birth Born on April 10, 1984.
1999 15 Years Old 1 More Event
Moore toured with N'SYNC throughout the first half of 1999.
2000 16 Years Old 2 More Events
2001 17 Years Old 1 More Event
In June 2001, Moore released her second full-length album, her third overall, the self-titled album Mandy Moore. … Read More
2002 18 Years Old 1 More Event
The early 2002 release of the final single, "Cry", tied in with the film A Walk to Remember, Moore's debut as a lead actress.
2006 22 Years Old 4 More Events
In 2006, Moore guest-starred in two episodes of Scrubs: "My Half-Acre" and "Her Story II". … Read More
2007 23 Years Old 4 More Events
Moore performed the song at the Brick Awards on April 12, 2007 and launched a tour in the summer of 2007. … Read More
2008 24 Years Old 1 More Event
On February 23, 2008, Moore released Wild Hope in Australia, and subsequently toured with Ben Lee and the West Australian Symphony Orchestra in Western Australia, supporting Kelly Clarkson on her tour.
2009 25 Years Old 2 More Events
Moore has dated Adam Goldstein aka DJ AM, singer Billy Crawford, tennis player Andy Roddick, and actors Wilmer Valderrama and Zach Braff. She married musician Ryan Adams on March 10, 2009, in Savannah, Georgia.
2010 26 Years Old 1 More Event
Moore also starred with actor Kellan Lutz in the 2010 film, Love, Wedding, Marriage.
2011 27 Years Old In October 2011, it was announced that she is set to star in an ABC comedy titled Us and Them. … Read More
2012 28 Years Old 2 More Events
Along with her voice role in the upcoming 2012 Tron: Uprising animated series, she is also set to be the title character voice in the Disney Junior series Oki's Oasis. … Read More
Original Authors of this text are noted on http://en.wikipedia.org/wiki/Mandy_Moore.
Text is made available under the Creative Commons Attribution-ShareAlike License.
Not the person you were looking for? Search Mandy Moore
Text is made available under the Creative Commons Attribution-ShareAlike License.
Not the person you were looking for? Search Mandy Moore


text:
michael in MT
Top quality parts equal to or surpassing OEM replacement, for a great price. Super fast shipping,in stock ready to go. Thanks rockymountainatvmc,I will definitely be back!Read All Reviews
Kyle in AZ
I've broken bones and the radiators are still fineRead All Reviews
Kyle in AZ
So it worksRead All Reviews
Garrett in PA
Haven't overheated yet since I put this cap on! CV4 offers a 1.4 and 2.0 bar cap. I went with the 2.0 because I run woods races and that's the last thing I need is to loose coolant. Costed me a top end earlier this year so never again will I run a stock cap...Read All Reviews
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Run with distilled water and never have an overheating problem. Radiators don't even get that hot anymore!Read All Reviews
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Great coolant, but it is not antifreeze! For racing though, this stuff just downright works!Read All Reviews
Rocky Mountain ATV/MC has a complete inventory of cooling system parts to keep both you and your dirt bike's engine cool during any race. Find the exact coolant you need with our selection of dirt bike coolants from the best brands in the industry like Bel-Ray, Liquid Performance, Maxima, Pro Honda and Cycle Logic. We also have the cooling parts you're looking for like water pump covers, hose kits, radiators, radiator guards, radiator caps, water coolers, radiator braces and radiator cages. If you're not sure which parts will fit your machine, use our "Parts Finder" search to find the parts made for your dirt bike's make, model and year. Ordering several parts at once can quickly add up, which is why Rocky Mountain ATV/MC offers free three-day shipping on orders over $99.00. Plus, you always get your dirt bike cooling system parts sooner than expected. There's no reason to shop for dirt bike parts anywhere but Rocky Mountain ATV/MC.com.


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Narrow your search
A fitness band that converts into a Bluetooth headset? Genius! This $180 device uses Jawbone's Up technology.
Despite its unique two-in-one design -- it's a fitness tracker and Bluetooth headset -- the Huawei TalkBand B2 ultimately overpromises and underdelivers on both accounts.
The TalkBand B2 is an activity tracker combined with a Bluetooth headset. CNET's Dan Graziano gives you a first look.
Stepping into the void of Apple's silence on sales figures, a research firm finds clues to how well the Watch is doing.
From starting your own channel to monetising your music, here's how you can make your videos sing.
The company that had a search engine in the '90s plunges into wearable security and fitness. Do you trust them to manage your passwords on a Lycos Life Band or Ring?
The WRT1200AC is just way too expensive for a second-tier 802.11ac router.
The Kickstarter project straps 1,500 milliamperes' worth of power to your wrist. There's just one catch.
A key feature of Apple's new smartwatch is the ability to switch bands, and Apple is telling third-party developers how to design them.
Is there room for a plain old fitness band with no screen in an age of smartwatches? Jawbone's new band has fantastic software, but its heart rate tracking's just not useful enough.


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text:
I missed the advance sale. When do the rest of the passes go on sale?
The remaining passes will be going on sale once the line up is announced. There is no specific date yet.
I missed the advance sale. When do the rest of the passes go on sale?
The remaining passes will be going on sale once the line up is announced. There is no specific date yet.
This needs to get stickied.
Wasn't that on there before the advance sale even started?
5/15-17/15 - Psycho CA @ Observatory // 5/22/15 - Laura Jane Grace @ Hollywood Forever Cemetary // 5/27/15 - Neutral Milk Hotel @ Warner Grand Theater
6/3/15 - Sufjan Stevens @ Dorothy Chandler // 7/15/15 - Shellac @ Regent // 7/31/15 - Melt Banana w/Torche @ Roxy
Yeah but the swarm of users with less than 50 posts came in and got everyone thinking about it.
Whiskey Sour
2 oz blended whiskey
Juice of 1/2 lemon
1/2 tsp powdered sugar
1 cherry
1/2 slice lemon
Shake blended whiskey, juice of lemon, and powdered sugar with ice and strain into a whiskey sour glass. Decorate with the half-slice of lemon, top with the cherry, and serve.
it never said coachella was sold out anywhere.
.................................................. ..............
She added the phrase "meany head" to my profile.I hardly think I'm an attention whore.I train birds of prey and am I licensed falconer
^ someone quote this every chance you can.
May 15-17 - Psycho California
June 6 - The Rolling Stones
June 10 - Melvins
June 20 - Blur
June 24-28 - Glastonbury
July 18 - Death Grips?
July 26 - Faith No More
September 25 - Kraftwerk
Who says there are any remaining passes?The remaining passes will be going on sale once the line up is announced. There is no specific date yet.
finally. now shut the fuck up people. its not sold out completely. Tickets will be going on sale in January.
Upcoming Shows:
U2: 6/28 @ United Center
Lollapalooza: 8/1 @ Grant Park
This space for rent.
You're a complete moron. If you can't buy a ticket during onsale wait until the week of and you can grab a ticket for face value or under face. Ridiculous.
5/9 - Suishou No Fune (水晶の舟) - The Empty Gallery - HK
6/7 - NHK'Koyxeи / Mark Fell - The Empty Gallery - HK
I really don't think there is enough panic about ticket sales. If there are any tickets to be sold in January, they'll sell quicker than 1st and 15th crack.
Wow, 12 step meetings at Coachella, who knew? SOBERCHELLA.COM
I'm a reasonable male, get off my case....
Those that were on the general sale last year that got online the second it opened did not get tickets. Reports from last year had Frontgate selling 60 of the 75k during presale.
You'll have 15k tickets for everyone and their mother trying to get em. Those that are smart will go right after weekend 2 rather than rushing with the masses to get weekend 1.
A moment of silence for those who will try to get tix during the regular onsale.


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A half inch of steady soaking rain fell overnight Tuesday at the North Platte Regional Airport/Lee Bird Field, bringing much needed moisture to the area.
The forecast calls for good weather through the end of the week, with temperatures in the 70s and a slight chance of rain through Thursday.
The high temperature could reach the mid-80s early next week, the weather service said.
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We partner with wilderness and therapeutic program
professionals to provide scholarships and support to families
with financial limitations as they complete the therapeutic
programs that they desperately need, but may not be able to afford.
Averaging thirty initial applications per month, SavingTeens is consistently faced with difficult decisions. Your generous donation to SavingTeens will allow us to select more struggling teens and families for this life-changing support. Please consider a generous donation to this important endeavor.
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The 2014 SavingTeens Charity Golf event was played February 5, 2014 at the Legacy Golf Club in Henderson, Nevada. This represents the third year we have held this annual event in conjunction with NATSAP (National Association of Therapeutic Schools and Programs) Annual Conference.


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From brawling on the cobbles to scuffles in the Queen Vic, see the soaps' cattiest moments.
Spectacular lightning lit up the sky last night across much of the country as storms rolled in.
We show you how you can make the contents of your fridge last longer than ever before.
Nine years after the end of WWII, rationing in Britain finally ended on this day in 1954.
Find out how these Rubik's Cubes help explain optical illusions.
See how Adam Croft and Nikki Pepperrel have quite literally packed it all in.
Running low on disk space? If so, follow our guide to de-clutter your hard drive.
Chelsea v Arsenal among the highlights - and Man United v Tottenham will kick off the season.
Even if you've signed up for Windows 10, you might not get it straight away.
Natalie Lawrence spent months creating replica - so she could have her own prince at home.
The best of Coronation Street, Emmerdale, EastEnders and Hollyoaks for the next 7 days.
See the likes of Heather Watson and Maria Sharapova all glammed up on the red carpet.
BT's partnership with Williams Martini Racing revs into gear at Silverstone.
An air passenger paid £3.20 for this very sad looking bacon and egg sandwich.
As temperatures stay high this week, check out 11 tips to keep your home cool.
Find out why it was suggested the entire population moved to Northern Ireland.


text:
(LOS ANGELES, CA) -- On February 2, 2013, the Dr. Susan Block Show will broadcast live on location from the West Coast premiere of The Deep Throat Sex Scandal, a hot new play by David Bertolino about the making of the notorious, groundbreaking, 1970s porn film "Deep Throat" and the subsequent controversies it ignited.
Joining international sexologist Dr. Susan Block live on the air from the Zephyr Theater in West Hollywood right after the play will be Deep Throat Sex Scandal cast and crew, including Natasha Parker (Linda Lovelace in the play), Marc Ginsburg (Harry Reems), veteran adult film stars Veronica Hart and Herschel Savage, producer/writer Bertolino and director Jerry Douglas, plus Golden Globe award-winning actress Sally Kirkland and renowned Oscar-winning comic writer and performer Bruce Vilanch, who also have parts in the evenings production.
"Deep Throat sparked the porno chic wing of the sexual revolution, important Free Speech court cases, Watergate code and various ongoing scandals, and had millions of women checking their tonsils for their clitoris. We cant wait to see the play and go deeper
" says Dr. Block.
Tickets to the play are available at http://deepthroattheplay.com or by calling 800-838-3006.
Dr. Blocks "Deep Throat Interviews" will air live February 2, 2013, 10:30pm-Midnight PST on DrSuzy.TV. Listen Free at http://drsusanblock.com/TV.html
The Dr. Susan Block Show is produced by the Dr. Susan Block Institute for the Erotic Arts & Sciences , an international center for sexual expression, therapy and education, based in LA. Founded in 1991 by Susan M. Block, PhD, world-renowned Yale-educated sexologist, best-selling author and host of HBO specials, the Institutes mission is to help individuals, couples and communities enhance their sexuality and improve their lives based upon Dr. Blocks philosophy of Ethical Hedonism and the Bonobo Way of Peace through Pleasure.
David L. Ross
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Shade X from Smash
BBW Con 2015
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Nikki Phoenix Radio Update
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XBIZ 2016 Announced
The Interview XXX
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Mercy West Available
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Payton Sin Claire on SDR
Angela Sommers in Houston
Prinzzess at Treasure Chest
Danica Dillon in Bath
Sin Claire with Foxxx
Adult's Achilles Heel
AHF's Hidden Agenda
New Smash VP Wyatt Case
Ink Inks OC, The Rub
National Porn Star Day
Pistol, Ross Talk Condoms
XXX Casting Call
Direct Reps Harper
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Emma Marx: Boundaries ~ Reviewer Rated
Strippers Ready for Baseball
RAW Signs Sasha Bradshaw
Modern Comstockery
Nikki Phoenix Appearance
Welcome 2015!
Actress as an Artist
Merry XXXmas, Happy Xanukkah
Pushed Into the Corner
Bright Lights, Lonely Nights
Halloween Art Show
Sex Workshop Hustler San Diego
Fake Test Results
CET Free Panel Month
TTS Welcomes Bobi & Jen
Cutting Edge Changes Staff
Next Day Test in LV
Condomless Sex
Fetish Con Dates
Gloria Leonard Memorial
Valentine's Tips
Kinky Valentine Cards
Dammit He's Dead
Death at Bunny Ranch
Sara Jay not Dead
Glory Stories Batts Fundraiser
Daisy Marie hosts Philippines Relief
Fairvilla Movember Bash
Nadia Night Back From Rehab
Altar dedicated to Guccione
Alex Gonz Hep C Statement
CSC Preserves AIDS Poster
Bible Study with Kurt Lockwood
CineKink Screens at BedFEST
Shibari Speaks at Woodhull
Baci Launches Halloween Contest
ASACP to London XBIZ EU
Wicked Heads AIDS Walk
Yahshua Seeks Help
Alesia Pleasure at Bare Bowling
LATATA Hep C Statement
Bare Bowling is Back
LATATA Advises Performers
drake Leads AIDS Walk
CineKink in Oakland
CineKink Kicks Off
Vice is Nice Charity Event
CineKink 2013 Tour Dates
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Sandau Scholarship Fund Established
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CatalystCon West Pre-Con Events
Wrestle Erotica Celebrity Fundraiser
Gamelink to Senator Robert Ford
CatalystCon Speakers, Sponsors


text:
What's Cookin' at Brown Dining
Summer Hours
- Blue Room is open weekdays 7:30am to 3:30pm and Sundays 8am to 2:30pm
- Faculty Club is open weekdays 11:30am to 2pm, Wed to Fri 5pm to 8pm
- Sharpe Refectory is open daily, 7:30am to 9:30am, 11am to 2:30pm, 4:30pm to 7:30pm
- Verney-Woolley is open from Sunday dinner through Friday lunch, 7:30am to 9:30am, 11am to 2:30pm, 4:30pm to 7:30pm
- See when our semester hours begin...
- View your current meal plan
- Pick the right plan for you
- How to make a change & deadlines
- Club Plan for Seniors
- Note to students returning from abroad: you are not auto-enrolled in a meal plan
Click on "Personal Information", then on "Meal Plan and Brown Card Declining Balances".
To cancel your meal plan call 401-863-3343.
Tuesday 9/8 is the deadline to make changes without a fee. There is no deadline for adding a meal plan. All Fall 2015 changes and full-year cancellations must be made by Wednesday 9/30
- Think of the Faculty Club for a quick takeaway lunch order: Caesar Salads, Creamy New England Clam Chowder, Salmon Salad and more
Refectory, Verney-Woolley, Blue Room
More Food for Thought
- #6 Healthiest College in the US: Brown ranks highly again for the quality of our healthy food options
- Andrews Commons: The BlogDailyHerald says, "Andrews Commons rocks"
- Our pizza crusts are now made with Vermont-milled King Arthur flour!
- Brown Dining donates leftover food to Food Recovery Network, which has already provided 37,000 lbs of food to local pantries
- Vegan Friendly: Brown got another A grade in PETA's college scorecard
- A Real Food Pioneer! Brown is a recipient of the first ever Real Food Awards
- Top 10 Healthiest Colleges: Brown ranks high for students leading healthy and happy lives
- Green Certification: Brown Dining was honored this year by the RI Hospitality Association and RI Department of Environmental Management for our environmental practices


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Garlic Bites
27 Dec 2009
|White bread slice
|Low calorie margarine
|2 Teaspoon
|Garlic powder
|1⁄4 Teaspoon
Remove crust from bread; cut bread into 1/4 in. (6-mm) cubes.
Melt margarine in small pan.
Add garlic powder and heat until sizzling.
Add bread cubes; saute, tossing frequently until brown.
Drain and cool.
Rate It
0 Comments
Garlic Bites Recipe


text:
Photo by Offaly Tasty.
I love Maangchi's doenjang Jjigae so much, it has become a regular on my table now. I eat it at least twice a week. Definitely one of my favorite foods, I had no idea I would like it so much, it really surprised me. Thank you Maangchi!
The recipe is here.
Posted Wednesday, May 22nd, 2013 at 11:34 am
Tagged: doenjangchigae image, doenjangjjiage meal, 된장찌개 이미지, Korean doenjang stew, Korean fermented soybean paste stew, korean food, Korean food blog, Korean food images, Korean food website, Korean kitchen, Korean recipes, Maangchi recipes, Offaly Tasty
I know what you're going to do next, just by looking at the hot pepper paste on top of the rice! Mix mix with the sauce and the vegetables! Sesame oil~!
Mouthwatering photo!
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On a mission to find some nice rocks his wife could use as accent pieces in her Circle Pines garden, Gary Buhr searched the ground at his family farm in Black Brook, Wisconsin....Read More
Circle Pines
Jennifer Kromrey has worked in an optometrist office, been a childcare provider and a special educational paraprofessional at a local high school, but one goal she has always wanted to achieve was a four-year degree....Read More
A 48-year-old man pleaded guilty Oct. 30 in Anoka County District Court to a felony terroristic threat charge related to a Sept. 4 fight with his brother....Read More
Within a month of opening his business in Circle Pines in 1999, Brett Nelson had 25 people working for him. He now employs over 175 people and expects to peak around 300 employees with his latest expansion project....Read More
A 55-year-old Circle Pines man attempted suicide by jumping off the fifth floor of the parking ramp at the Anoka County Government Center about 7 a.m. this morning (April 30). ...Read More
The red and blue strobe lights from the police car flash in the room as the officer talks to the woman huddled on the couch. ...Read More
A regional consortium spearheaded by the Coon Rapids City Council for street maintenance materials and services will continue this year....Read More


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Long Beach Day Care
204 day cares near you in Long Beach, CA. Join Care.com for free and find the best one for your family.
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Responsibilities: Define, develop, and implement a GUI test automated infrastructure; Develop tests and execute tests based on the test plans developed for GUI functionality; Work with Developers to isolate and fix: GUI issues, performance problems, scalability constraints and5/30/2015 Nashua, NH Save This Job
Job Description Senior Software Engineer ? Design and implement applications for network management systems Start Date: Immediately Compensation Range: Rate dependent upon experience and qualifications. Location of Work: At company headquarters, with some travel required5/30/2015 Portland, OR Save This Job
Job Description: DataGravity is an award-winning startup, developing an innovative storage solution that provides customers with truly data-aware storage. We are currently looking for a Senior QA Engineer to join our growing team in Nashua, NH. Our team is comprised of QA5/30/2015 Nashua, NH Save This Job
at Houzz Palo Alto We are looking for a world-class software engineer to join our family and be part of our entrepreneurial development team. You will take high level ideas and transform them to live products, used by millions of homeowners and professionals from around the5/30/2015 Palo Alto, CA Save This Job
As an Aerospike DevOps Tools Engineer, you will be a member of a team in charge of creating a variety of impactful tools to operate and support Aerospike clusters. Your responsibilities will range from deployment automation tools to statistic and log file gathering and analyzing,5/30/2015 Mountain View, CA Save This Job
Houzz is looking for a passionate computer vision scientist who has extensive experience in computer vision research and loves building computer vision applications. Houzz provides our users with professional home design photos that help them design and remodel their homes. We5/30/2015 Palo Alto, CA Save This Job
You will: Be responsible for overall quality of Technical Documentation, including content creation, content delivery, and content management. Develop documentation for software developers and system administrators. Write, organize and update developer documentation, including5/30/2015 Mountain View, CA Save This Job
As a Test Development Engineer, you have the opportunity to improve the quality of Aerospike. You will be part of an Engineering team, developing code rather than fixing or finding bugs. You will be responsible for designing and implementing tests that push the limits of5/30/2015 Mountain View, CA Save This Job
As a Test Infrastructure Engineer, you have the opportunity to automate the testing and improve the quality of Aerospike. You will be responsible for designing and implementing test automation infrastructure using Mesos, Docker, Virtual Machines and cloud hosting providers. You5/30/2015 Mountain View, CA Save This Job
Key Responsibilities: Work closely with the product design team to design and refine the Stride Health?s core consumer product experience in a way that best leverages available data sets and analytical methods Build and validate statistical models to help change consumers?5/30/2015 San Francisco, CA Save This Job
Houzz is looking for a passionate engineer who has extensive experience in search infrastructure to join our back-end engineering team. On Houzz, users have access to a massive collection of high quality home design photos, information on products, designers and home5/30/2015 Palo Alto, CA Save This Job
Department: Engineering Location: Boston, MA Does running thousands of machines in the cloud without ever logging into a single box sound like the future to you? Do you like building resilient systems where even a second of downtime is unacceptable? Do you like architecting5/29/2015 Boston, MA Save This Job
SANTA MONICAENGINEERINGFULL-TIME APPLY TO THIS JOB Victorious is building the next generation mobile platform that powers superfan apps for the world?s biggest creators and their communities. We?re looking for someone to help design and develop reliable and scalable applications5/29/2015 Santa Monica, CA Save This Job
Requisition Number:692 Job Title:Front-End Developer Area of Interest:Marketing Position Type:Full Time - Permanent Shift: Location:Remote Employees-Home Based City:Nationwide-Remote State / Province:Nationwide-Remote Requirements: See Job Description Below Job5/29/2015 Jacksonville, FL Save This Job
Recommind has just been praised as one of the ?World?s Ten Most Innovative Companies in Big Data? by Fast Company and awarded a position in the ?Leaders? Quadrant of Gartner?s 2013 report, ?Magic Quadrant for E-Discovery Software'. We were also recently placed on Deloitte?s5/27/2015 Norwood, MA Save This Job
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Description Company Overview: Market Force is the leading global customer intelligence solutions company for multi-location businesses, including major retailers, restaurants, grocery and convenience stores, financial institutions, entertainment studios and consumer packaged5/27/2015 Norcross, GA Save This Job
Location: Ann Arbor, MI Department: Engineering Type: Full Time Min. Experience: Mid Level We've developed the groundbreaking DeepField Cloud Genome technology, a big data platform to power it, and a slick UI to show it off. Now that we have one of the coolest real-time datasets5/27/2015 Ann Arbor, MI Save This Job
Job description Violin Memory is seeking an experienced software engineer to join its System Kernel/IO core SW team. Candidate shall be responsible for maintaining existing software including kernel and application components as well as adding/extending features. Candidate shall5/27/2015 Santa Clara, CA Save This Job
The Sustaining Engineer will handle technical issues escalated from Customer Support, QA, partners/resellers and other organizations. He/she will develop code changes and/or workarounds to address product defects, design and implement new features and tools, and work with 3rd5/27/2015 Santa Clara, CA Save This Job


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Arrest made in suspicious letters sent to Colorado JCC, synagogue
A 32-year-old man has been arrested for sending letters containing white powder that turned out to be "benign" to two Jewish organizations in Boulder, Colorado. More ▸
A 32-year-old man has been arrested for sending letters containing white powder that turned out to be "benign" to two Jewish organizations in Boulder, Colorado. More ▸
If all goes according to plan, Seth Wong and business partner JJ Slatkin's Denver lab will be trading moldy bagels and racehorse urine for cannabis — lots of it. More ▸
Rep. Brad Schneider lost his Illinois seat and Jewish challenger Andrew Romanoff came up short in his bid for Congress in Colorado. More ▸
Need kosher food on the slopes? Something for the kids or non-skiers in your family? JTA runs down the five best spots in America for Jews to test the powder this year. More ▸
When cities twin, do they embrace narratives? One Colorado city debates. More ▸
Swastikas were spray-painted on buildings in several cities in Colorado. More ▸
As wildfires spread and some 30,000 Colorado residents were evacuated from their homes, the communal sense was widespread, in and out of the Jewish community. More ▸
A Colorado synagogue was spray-painted with anti-Semitic graffiti in honor of Adolf Hitler's birthday. More ▸
Rick Santorum won three contests in the race for the Republican nod for the presidency. More ▸
Just past high noon yesterday, Jamie Korngold, aka the Adventure Rabbi, led me up into the hills overlooking Boulder. "Welcome," she said, "to my synagogue." Korngold has already got a ton of press for her expanding offerings of Jewish wilderness experiences, and it's easy to see why. She photographs well, answers questions in near-perfect paragraphs,… More ▸
Also From 70 Faces Media


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Once Upon A Time - Season 2 Thread
View Single Post
May 13 2013, 07:12 PM
Rear Admiral
Location: West Haven, UT, USA
Re: Once Upon A Time - Season 2 Thread
Vendikarr and Sojourner:
Yes, we saw Aurora, Phillip, and Mulan find Neal on a beach, but Adam and Eddy just did an interview with Entertainment Weekly, and when the interviewer asked them a question and specifically mentioned Neal being in the Enchanted Forest/FTL, the two of them answered the question as follows:
So now we've got the Neverland stuff, we've got Bae and Mulan in Fairy Land, we've still got Storybrooke — how do you plan to cross between worlds next season? Will episodes still include flashbacks?
At the end of season 2, we've placed our core group in a very difficult situation. Some of them are on the boat; some of them are behind in Storybrooke; some of them are in
another land
. So the question is, how do we best continue telling their stories? Sometimes that will require flashbacks; sometimes it won't. We want to continue to expand the storytelling modality of the show, like we did in season 2, where we were able to do things like flash back to Emma for the first time, or see time during the curse.
We are not going to be doing episodes next season that have five different worlds in them. We definitely plan not to overly confuse or complicate the show. It's about simplifying.
Hence my statement of it not having been confirmed that Neal is in the Enchanted Forest/FTL.
: We're all friendlies. So, let's just... be friendly.
"There is no 'supposed to be.' It's an adaptation, a word that literally means change. Why bother making a new version if it doesn't offer a fresh approach?" - Christopher L. Bennett
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text: Stayed in the loft and it was a lovely room. The decor is traditional and it is a typical bed and breakfast so if that's what you are expecting you will be happy here. Lovely couple and a great place to stay. It is such a great value, especially because you can park and walk to the Falls.


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Ingredients: Active Ingredients: 5 X dilution of Salix vitellina HPUS.Inactive Ingredients: 27% Alcohol.
Keep out of reach of children. If pregnant or breast-feeding ask a health professional before use.
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Bach Flower Remedies Essence Willow -- 0.7 fl oz
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Original Flower Essences per Dr. Edward Bach - Helps You to Forgive Past Injustice and Move On When you Feel Resentful and Bitter.
For Naturally Occurring Nervous Tension.


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Eastern Conference
Brooklyn Nets @ Atlanta Hawks
The Nets can win if C Brook Lopez keeps playing like an All-Star and overpowers C Horford, forcing the Hawks to double-team him and open up shots for the Nets' perimeter guys. However, the Hawks will win because they are a well-oiled machine where players will consistently step up and cover for one another. Moreover, they're a confident team led by a superior coach, and will be too multi-dimensional for the Nets to counteract.
Hawks in 5
Boston Celtics @ Cleveland Cavaliers
The Celtics can steal this series if their deep backcourt controls PG Kyrie Irving. The Celtics actually flourished after the all-star break, and are rolling right now. However, the Cavaliers will win handily because LBJ will dominate the Celtics by feeding easy buckets to C Mozgov and PF Thompson, taking pressure off playoff-rookies in Love & Irving.
Cavaliers in 5
Milwaukee Bucks @ Chicago Bulls
The Bucks can steal this series if F Middleton limits Butler and PG MCW destroys Rose, and their collective athleticism and length forces the tempo into their liking. However, the Bulls will win because even if PG Rose and SG Butler are shut down, they can go to Pau Gasol – he averaged 24 and 13 against the Bucks this season. The Bucks do not have enough offensive firepower to keep up with the now-versatile Bulls (Noah and Gibson up front, Dunleavy and Hinrich from outside, and the unstoppable Mirotic off the bench).
Chicago in 6
Washington Wizards @ Toronto Raptors
The Raptors can win if PG Lowry wins his matchup vs PG John Wall, and they actually play defense for a change. The Wizard will win if Wall relentlessly attacks the hoop instead of settling for the open jumper. As long the Wizards play stout defense and slow down the pace to prevent the Raptors from going off, the series won't go the distance.
Wizards in 6
Western Conference
New Orleans Pelicans @ Golden State Warriors
The Pelicans can win if Anthony Davis completely dominates the paint and limit the Warriors to jumpshots. Yes, they're good from outside, but they're also prolific slashers. However, the Warriors will win cuz they're nigh invincible at home (39-2), and they have a stout interior defense in Bogut and DPOY favorite, Draymond Green. Expect the Splash Brothers to detonate regardless of what the Pelicans do.
Warriors in 5
Dallas Mavericks @ Houston Rockets
The Mavericks can win if SG Ellis offsets MVP candidate Harden, on offense and defense both, and both PF Nowitzki & SF Chandler are effective and productive. However, the Rockets will win because of the Beard, who hasn't led the team into the second round. As long Howard controls the paint and the combination of veterans in Prigioni & Terry step up, the Rockets will eke out a competitive 7 game victory.
Rockets in 7
San Antonio Spurs @ Los Angeles Clippers
The Clippers will win if PG Paul consistently feeds PF Griffin inside, who can out-athlete either defender (Splitter or Duncan) and control the pace. However, the Spurs will win because they're peaking at the right time. Even though they're playing on the road, the veteran Spurs will not get rattled. Expect SF Leonard to dominate his inferior counterpart in Barnes or Crawford and lead the Three Amigos to the second round.
Spurs in 7
Portland Trailblazers @ Memphis Grizzlies
The Blazers can win if PG Lillard and PF Aldridge dominate, and their bench steps up. However, the Grizzlies will win as long they go through their bigs in PF Randolph and C Gasol. The Grindhouse is a tough place to win. Then again - neither team is at full strength, so it could come down to whichever team's replacements steps up.
Grizzlies by 6
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The HereticMember Since 24 Dec 2004
Offline Last Active Today, 03:33 AM
Community Stats
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- Member Title ironic nihilist & cheerful pessimist
- Age 39 years old
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Philosophy (Nietzsche, Schopenhauer, Post-Structuralism, Existentialism, German Idealism)
Literature (Bret Easton Ellis, Dostoyevsky, Jorge Luis Borges, William Gibson)
Anime (Evangelion, FLCL, Samurai Champloo)
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- 76Promote
Art Print
Catby Anne Staub
Collect your choice of gallery quality Giclée, or fine art prints custom trimmed by hand in a variety of sizes with a white border for framing.
"Easy care"
anne, staub, cat, pet...
Gorgeous! I love this one!
Warm and lovely image!
what a sweetie! mine tries to fit in any box or bag too....but her little tummy often hangs over the edge:(
Really delightful! Great image, Anne!
Sweet. :-) I can see it's not just my cats who like boxes. LOL
so cute!!!!
Thanks everyone :)
So cute and a wonderful capture
Thank you very much Ally :)
Precious!! - we didn't get to keep any of the kittens! ) :
Easy Care Vs Easy Life:) Lovely pet capture!
Thank you very much Micklyn and Chris :)
Mine LOVES boxes too! Great picture!
Thanks Angelo :) and he's only "easy care" as long as nothing changes :)) fussy cat! :))
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Sacred Marriage: What if God Designed Marriage to Make Us Holy More Than to Make Us Happy?(Spanish) -ebook
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Sacred Marriage: What If God Designed Marriage to Make Us Holy More Than to Make Us Happy? - eBookGary L. ThomasZondervan / 2008 / ePub$8.99Availability: In StockCBD Stock No: WW2868EB
Publisher's Description
Author Bio
Gary Thomas es escritor residente en la iglesia Second Baptist de Houston y Profesor asociado en el Seminario Western en Portland, Oregón. Es autor de más de una docena de libros, incluyendo Matrimonio sagrado, Placer puro y el ganador del Golden Medallion, Fe Autentica.
Author Bio:
Publisher's Description:
Scores of books have been written that offer guidance for building the marriage of your dreams. But what if Gods primary intent for your marriage isnt to make you happy . . . but holy? And what if your relationship isnt as much about you and your spouse as it is about you and God?
Everything about your marriage--everything--is filled with prophetic potential, with the capacity for discovering and revealing Christs character. The respect you accord your partner; the forgiveness you humbly seek and graciously extend; the ecstasy, awe, and sheer fun of lovemaking; the history you and your spouse build with one another--in these and other facets of your marriage, Sacred Marriage uncovers the mystery of Gods overarching purpose.
This book may very well alter profoundly the contours of your marriage. It will most certainly change you. Because whether it is delightful or difficult, your marriage can become a doorway to a closer walk with God, and to a spiritual integrity that, like salt, seasons the world around you with the savor of Christ.
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Daily Sales Up to 70% OFF Limited-time deals start every day at 12 pm ET.
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Grillpro 12" Bamboo Skewer
Grillpro 12" Bamboo Skewer
Weights & Dimensions
|Product Type: Skewer and shish kebab
|Country of Manufacture: China
About the ManufacturerWith over 25 years experience specific to the parts and accessories market, in product, distribution and importing, Grillpro has emerged as one of the industry's most comprehensive single source supplier's in the category. Grillpro delivers innovative products, a dedicated management team, a distribution facility that provides responsive service and timely delivery, and a comprehensive website featuring recipes and products.
Grillpro 12" Bamboo Skewer
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Tell us what you think about this product. It will help us provide you with better products in the future and help your fellow shoppers make better purchases.Write the first review
OUR SKU # OWGP100912" Bamboo Skewer is also sometimes listed under the following manufacturer numbers: 11070


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College News
St. John Fisher College Receives $50,000 Grant from the New York Higher Education Services Corporation Grant
St. John Fisher College has received a $50,000 College Access Challenge Grant (CACG) from the New York State Higher Education Services Corporation (HESC) which is being used to support a comprehensive college-readiness program with students from James Monroe High School in Rochester.
The federal CACG program is designed to help low-income, at-risk students gain the knowledge and skills necessary to successfully navigate the college admissions and financial aid process. HESC has administered New York's CACG Program since its inception in 2008.
Up to 50 tenth and eleventh-grade students, identified by guidance staff and teachers, are enrolled in Fisher's program, which runs from December 3, 2012 through August 1, 2013. The program also actively engages the students' parents/guardians and the high school guidance staff.
Fisher has worked with James Monroe High School guidance counselor staff to provide information and training on college requirements, financial aid, the admissions process, and what is expected from students.
Students and parent(s)/guardian(s) will attend summer workshops focused on the college admissions and financial aid process, preparing students to successfully graduate from high school, college requirements, exploring college majors and career options, and SAT preparation. Later in the summer, students will also have the opportunity to attend college tour(s) and participate in a one-week summer residential experience at Fisher, staying in residence halls, to experience college residential life. Throughout that week, students will work both individually and in small groups, participating in team-building exercises, familiarizing themselves with aspects of the college search and selection process, and receiving information and ongoing support related to the college admission process.
Check out photos from Fisher's 2015 Commencement Ceremonies on Flickr!
Latest College News Stories
- Westbay Begins Role as Interim Dean of the College School of Arts and Sciences
- Rooney's Tenure as St. John Fisher College President Begins
- Lavery Library Earns Several Awards
- Media and Communication Alumna Receives Rising Star Award from Local Public Relations Society
- Area High School Students Honored for College Club Participation
- Four Nursing Faculty Present at National Conference
- Fisher Ed.D. Candidate Praised for Improving School Attendance
- Fisher Hosts Roundtable Discussion for Government Relations Professionals
- Hundreds Celebrate Dr. Bain's Presidency during Tribute Gala
- Wegmans School of Nursing Earns 10-Year Accreditation
- St. John Fisher College Receives $50,000 Grant for Liberal Arts-Business Education Initiative
- Humanistic Treatment in Mandated Counseling Focus of Faculty's Research Article
- Education Alumnus to Lead Rochester's Anti-Poverty Initiative
- Rice Contributes Two Chapters to Counseling and Psychopathology Encyclopedia
- Students, Faculty Attend Microbiology Conference


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Beautiful white male puppy with buff ears. Perfect small non-shedding breed. Intelligent, easy to train. Very friendly gentle disposition. Will mature about 10-12 lbs. Shots and 1-year genetic health guarantee included. $600 (301) 748-2180
May 11 -
Frederick :
Union Bridge - Dogs & puppies
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6 posts tagged with sobriety.
Displaying 1 through 6 of 6. Subscribe:
Staying dry in the one of the wettest cities in North America.
Why I Feel OK About Falling Off The Wagon After Years Of Sobriety
My elevator pitch for ending sobriety had been "moderate social drinking without ever blacking out again."
No thanks, I use video games to escape my reality
Are your "friends" pushing illegal marijuana cigarettes? Don't let drugs get in the way of your dream car! Keep sober with these snappy comebacks to narcotics. [SLYT Australian PSA]
"Caught between Recovery and the Coffin"
If I Die Young: Struggling with Addiction and Recovery. "Last year, 249 people died of prescription drug overdoses in Pinellas County, FL. Just about everybody who knew Stacy Nicholson figured she was next. Then an empathetic judge gave her a choice: recovery, or the coffin." [more inside]
"This is the largest market you've never heard of."
TheFix.com is a new site targeting the more than 40 million Americans who are recovering from drug and/or alcohol addiction. It features Ask-An-Expert videos, news, editorials and thorough reviews of rehab facilities based on Zagat's system. Founded by Maer Roshan, one of the founders of Radar Magazine. (Via) [more inside]
No thanks, I'm on Mineral Water.
No thanks, I'm on Mineral Water. As the MeFi Meetup commences, the Atlantic Monthly offers some tips for teetotalers. And, hey...a designated driver is always a good thing, no? (via a&l daily)
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FUSE have created a CG commercial for the Audi R8 Spyder.
Offsite News
Fuse - Single Player Trailer
The single player trailer has been released for Fuse, a shooter game from Insomniac Games.
Offsite News
Audi - 2014 Big Game Commercial
Audi has conceived a never-before-seen creature to show the frightening consequences of bringing compromise into the world.
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Marlboro - Car Projection Mapping
Check out another case of interesting projection mapping, this time on an Audi for Marlboro.


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MetaWars: Fight For The Futurethejeffnorton In the near future, two teenagers are swept up in the battle for control over the internet. MetaWars is a fast-paced YA thriller about the consequences o... read more
"Futuros Cruzados" {Kendall Schmidt}SimySRusher
The Future isn't BrightNemoNemo A choice, a desire, a new world; all of these are faced by Donna, a teenage outcast in a world beyond anyone's wildest dreams.
ESCAPE FROM THE FUTUREdeancmoore Less than forty years into the future, most of mankind has elected to upload themselves to digital nirvana, where they can live as many lives as they care to in par... read more
Next Futureialsantos Wade Mathew é um jovem cientista e informático que se dedica a experiências biológicas. A III Guerra Mundial Nuclear rebentou em 2020 e Wade conseguiu albergar-se num antigo ... read more
S.H.I.E.L.D: Escuela de Futuros Vengadores ©Carla_Alva Los nuevos vengadores han llegado, entérate de su historia. *100% original* Advertencia→Prohibido su copia o adaptaciones
Future Boyfriendvettevaneim A love story about a girl who gets an instant futuristic boyfriend. What will time and space could give them as they completely fall in love with each other?
When Past And Future Collides (Completed)DJDeeOfficial Time heals pain. Time cure wounds. Time can either Erase or Maintain memories. But what if Time makes you realize the important of itself. ... read more
Sterek- "A Visit from the future"LIGHTININGSHARK Derek and Stiles second son gets sent into the past while fighting evil fairies. While Genim tries to find a way back, he lets a few things about the future... read more
Porcelain Future | #Wattys2015AlanisCamacho •Cover by the marvelous @M_Saoit. Thank you!• 6/25/15 - #121 in Science Fiction In a far away future, women have become the rulers of the whole world as me... read more
X-Men: Días Del Futuro Pasado ❤La Mutante De Mis Sueños❤[Pausada Temporalmente]GiovaPierceMikaelson Charles pasó años sucumbido en el alcohol, pues beber era una triste manera de poder recordar, sentir y ver a Summe... read more
A Brief Future Of TimeJellalO_oKudo Experiment gone wrong, death, and two different clans bent on apocalyptic genocide: something that Sebastian Dawson, a time-travelling theoretical and experimental ... read more
Totaled: A Near-future Sci-fi ShortKaryEnglish Neuroscientist Margaret Hauri has two children to raise, and she's on the cusp of a scientific breakthrough. There's just one problem. She's dead. ... read more
Writers of the Future AnthologiesGalaxyPress For twenty-five years, L. Ron Hubbard's Writers of the Future Contest has discovered and nurtured a steady stream of new authors who have changed the face... read more
A Future To Die For || Nano 13Lauren8ob I never bothered to aim down my sights, I was blinded by the cascading snow. I just wanted to pluck a couple leaves, eat some Reese's pieces, and go home. Lea... read more
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