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How emixustat hydrochloride may help geographic atrophy
Treatment with emixustat hydrochloride may be useful for treating geographic atrophy by modulating visual cycle activity, reducing oxidative stress, and slowing accumulation of vitamin A-based toxins.
Seattle—Emixustat hydrochloride (ACU-4429, Acucela/Otsuka Pharmaceutical) may be a breakthrough in research into geographic atrophy in dry age-related macular degeneration (AMD).
This drug modulates visual cycle activity, reduces oxidative stress, and slows accumulation of vitamin A-based toxins. The drug appears safe and well tolerated with few serious adverse events, noted Pravin U. Dugel, MD, at the annual meeting of the Association for Research in Vision and Ophthalmology.
The non-retinoid small molecule is administered orally and inhibits activity of RPE65 to reduce the rate of vitamin A processing in the visual cycle. The specific activities include reducing vitamin A toxins, reducing the metabolic rate of the photoreceptors, and protecting the retina from light damage.
By inhibiting RPE65 activity, the visual cycle is slowed and production of A2E is reduced.
"Reduction of A2E would then theoretically slow progression of retinal pigment epithelial membrane damage, free radical production, increase inflammation, and the resulting contribution to the progression of dry AMD and geographic atrophy," said Dr. Dugel, managing partner, Retinal Consultants of Arizona, Phoenix, and clinical associate professor of ophthalmology, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles.
ENVISION Clarity Trial
A phase II multicenter, randomized, placebo-controlled, double-masked, multidose study (ENVISION Clarity Trial) evaluated emixustat hydrochloride (2, 5, 7, or 10 mg once daily in the morning, or 5 mg once daily at bedtime) versus placebo once daily (3:1 ratio) to assess the safety, tolerability, and pharmacodynamic effects (measured by dark-adapted electroretinography [ERG]) over 3 months.
Inclusion criteria included the presence of geographic atrophy, steady fixation and clear media to allow fundus visualization, and a best-corrected visual acuity of 20/400 or better in the study eye.
Seventy-two subjects were randomly assigned to one oral daily dose of emixustat hydrochloride or placebo for up to 90 days. Adverse events and other safety parameters were collected. ERGs were recorded 30 minutes after dark adaptation. The eyes were photo-bleached and ERGs were recorded immediately and at 10, 20, and 30 minutes. Rod b-wave amplitudes were expressed as a percentage of the pre-bleach, dark-adapted rod amplitude from baseline. The rate of rod recovery (slope) for each emixustat hydrochloride group was compared with the placebo group.
Common ocular adverse effects
In patients treated with emixustat hydrochloride, rod b-wave amplitude suppression (a measurement of rod activity) was dose-dependent, Dr. Dugel noted. In addition, the effects seemed to plateau by day 14. The pharmacologic effect was reversible when the drug was stopped and returned to the baseline level after 1 to 2 weeks off the study drug in all dosage groups.
Chromatopsia and delayed dark adaptation were the most common ocular adverse effects. Visual impairment also occurred in some patients.
"Moderate chromatopsia occurred in all treatment groups," Dr. Dugel said. "It started as early as day 2 and as late as day 52. The effects were intermittent or continuous and varied from 3 hours to 51 days. Two patients in the 5-mg group terminated treatment early because of serious chromatopsia. Fifty percent of patients had mild or moderate chromatopsia that resolved before the end of the study. In the 5-mg group, 10 of the 19 chromatopsia events were 7 days or shorter in duration."
Moderate delayed dark adaptation (intermittent or continuous) began as early as day 3. One patient receiving the 5-mg dose ended treatment early because of serious chromatopsia. Overall, mild and moderate delayed dark adaptation resolved in 25% of patients by the end of the 90-day study. Delayed dark adaptation was expected, Dr. Dugel noted, because of the drug's mechanism of action. Emixustat hydrochloride slows rod cell function, and because rods are responsible for sight in low-light conditions, delayed dark adaptation may result, he explained.
Moderate visual impairment (intermittent or continuous) occurred in the 2-, 7-, and 10-mg treatment groups. They initiated as early as day 2 and as late as day 48. The episodes varied in duration from 3 minutes to 37 days. Overall, 95% of cases of mild and moderate visual impairment that resolved before the end of the study.
"This dose-escalation study of 72 patients with geographic atrophy showed no significant systemic adverse events and the drug was generally safe and well-tolerated," Dr. Dugel summarized. "Most drug-related adverse events were ocular with mild to moderate severity and started within 2 weeks of dosing and resolved during the 90-day study. There was potential for a reduced incidence of chromatopsia with evening dosing."
A long-term phase IIb/III study is under way to evaluate emixustat hydrochloride in subjects with geographic atrophy.
Subscribe to Ophthalmology Times to receive the latest clinical news and updates for ophthalmologists.
ARVO 2013: Sight set on world-class science
Though the scenic backdrop of the Pacific Northwest at this year's meeting of the Association for Research in Vision and Ophthalmology (ARVO) may have been different from the traditional Floridian seascape, the meeting's world-class science continues to be at the forefront.
New glaucoma drug significantly lowers IOP
A new fixed-dose combination medication (Simbrinza, Alcon Laboratories) for the reduction of elevated IOP combines brinzolamide 1%, a carbonic anhydrase inhibitor, and brimonidine tartrate 0.2%, an alpha 2 adrenergic receptor agonist, in one multidose bottle. The drug is also the only available, fixed-dose combination therapy for glaucoma without a beta blocker in the United States, according to the manufacturer.
Report: Eye disorders cost $139 billion per year
Through improved communication and coordination with patients and other health care professionals as well as advocacy for increased or maintained funding for prevention of vision-related problems, ophthalmologists can help decrease costs associated with eye disorders and vision loss, according to a report commissioned by Prevent Blindness America.
The value of human ocular tissue in research
Human ocular tissue has a critical role in helping researchers understand and find new treatments for diseases that include glaucoma, age-related macular degeneration, and cataract.
Slow-release therapy for AMD, DME on horizon
Slow release of surrogate proteins over several months has been demonstrated in vitro from injectable hydrogel depots. This technology could help create long-term, sustained-release treatments of anti-vascular endothelial growth factor drugs.


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One On One Ads to Attend and Host Event at Borrell Local Advertising Conference
MAHWAH, N.J., March 15, 2012 /PRNewswire-iReach/ -- One On One Ads, Inc. announced their plans to attend the Borrell Local Advertising Conference to be held on March 21-22 at The Grand Hyatt Hotel at Grand Central Terminal in NYC. They will also sponsor a breakfast on the second day of the conference.
One On One Ads offers unique technology for online and mobile automated video creation and media campaign development. The company's video ad services enable any size business the ability to generate their own professional quality, high-definition video ads in an easy, user-friendly and cost-effective manner. Videos produced using One On One Ads' SaaS (software-as-a-Service) platform can be generated in a variety of formats suitable for use on the web, mobile devices, e-mail campaigns, TV, local cinemas, etc. Instantly redeemable coupons, available as clickable and printable, can be changed as frequent as necessary, and linked to any ad, to accommodate the ever-changing needs of every business.
Combined with proprietary production capabilities, media campaign management, cross channel video delivery, and a growing library of stock media, One On One Ads provides national and local advertisers and publishers with a comprehensive online video campaign solution. Videos can easily be downloaded and viewed via links to a company's website, Social Media outlets, QR and Bar Codes, etc.
The Company's OEM offering enables publishers, retail exchanges, and commercial sites the ability to provide branded video production capabilities directly to their end user customers. One On One Ads also offers services to the tens of millions of local businesses and private sellers, in all verticals, who want to use video for their marketing campaigns but cannot afford the time and expense of an advertising agency.
Arnon Scheflan, CEO and President of One On One Ads noted, "We have made significant progress in developing our innovative products and are poised to achieve extraordinary market acceptance and growth. We are delighted to have the opportunity to demonstrate our platform to so many potential clients in one place. We look forward to a very exciting and stimulating conference."
About One On One Ads, Inc. (www.oneononeads.com)
One On One Ads is a technology company founded in January 2011 that develops new solutions for wireless and online video commercials. The company's video ad services enable national and local businesses, as well as consumers to generate their own professional quality video commercials in an easy and cost-effective way. Video commercials produced with One On One Ads' services can be published in a variety of formats for the web, mobile devices, email campaigns, TV, and local cinemas.
One On One Ads, Inc. Contact:
Arnon Scheflan, President & CEO
201-358-6316 x11
Warren Stoll, VP Marketing
201-358-6316 x16
Michael Corrao, VP Business Development
201-358-6316 x17
News distributed by PR Newswire iReach: https://ireach.prnewswire.com
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- Arkwright
- Ronnie Barker
- Granville
- David Jason
- Nurse Gladys Emmanuel
- Lynda Baron
Buy online
Available on: DVD
From suppliers including: Amazon, BBC Shop
Open All Hours, Series 1 Episode 6 of 6
Duration: 30 minutes
Classic sitcom about a miserly shopkeeper. Arkwright has a sales drive with Granville demonstrating the product - very reluctantly.
Available on: DVD
From suppliers including: Amazon, BBC Shop
BBC © 2014 The BBC is not responsible for the content of external sites. Read more.
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|Fri - 19.09.14
Tuesday 22nd January, 2013
On this, the feast day of St Vincent Pallotti, we pray that we can continue to be united as a faith community. We pray for the common purpose of living and spreading the Good News. God gives us the words to speak, the compassion to be present and the love to serve. We give thanks for the work of St Vincent, and may his legacy give us the encouragement we need and refill our cup of courage. Lord, we pray for the strength of conviction, so that we may inspire other Christians to be authentic apostles of Christ in the church and the world.
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Summer night of Balkan soundsFeb 28th, 2013 | By hen | Category: Choir Events, European Choir Games, Featured Articles, Top Post
People who go through the gateway of Landhaushof in Graz on July 18, 2013 will enter a new world. "Balkan Spirit" is the name of the concert which is taking place this evening. Groups from Bosnia and Herzegowina, Serbia, Albania, Greece and Bulgaria and other countries in Southeast Europe have been invited to conjure the unique spirit of their folklore to Graz for this evening.
How it may sound shows the "Ethno Group of the Music School 'Josif Marinkovic'" from Serbia, watch here a performance in the Folklore category during the "World Choir Championships 2011" in Graz, Austria.
Come with us to the Balkans on July 18! Meeting point is the Graz Landhaushof featuring Music and Dance in a mild summer night.
The "Balkan Spirit" Concert is part of the "Long Night of Choirs" during the European Choir Games in Graz. Please find more info here.


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Cooking: Chef Elle Jones' Story
On my 35th birthday, I decided to do a health evaluation to see how my body was holding up after the birth of five children. When I listed my 36th ailment, I had a meltdown. Then I remembered something Morgan Freeman said in the movie Shawshank Redemption. "Get busy living or get busy dying." I began to read everything I could find about natural food and healing. My meltdown turned into revelation. With a sixth newborn packed snugly in my backpack and a six hour daily commute, I went back to school to study nutrition. That was then. Today, my stove is for decoration. I am 100% raw.
Five years ago, Rawsome Foods, Inc. was just a vision. Just before its birth, I remember going on a mountain climb with one burning question. Was this my destiny? Before I began, my climbing instructor said, "Let me carry your backpack. You don't need the extra weight. This is your first climb. You'll need all your strength." My guide said a lot of things that day. "Make the best decision for the moment. Not everyone makes it up the mountain. Some get halfway and turn back. Just keep climbing. Don't rest too long." I passed others. We were all here for different reasons. It was well over 100 degrees. I couldn't see – only feel, claw, pull up my weight, stretch, search for a foothold and begin again. The instructions continued, "Just when your footing seems sure, be cautious. If you fall in the easy places you won't have the strength to get up from the hard ones."
A trained guide can keep you focused, can keep you from making a fatal mistake, can make the climb with you, but can't make the climb for you. Sometimes, even when you follow their advice and are moving in the right direction, there are still obstacles like camouflaged boulders on the side of a mountain. Obstacles have a way of causing crystallizing moments when you realize that sometimes you have to backtrack around them to continue the climb. A few feet back…or all the way down.
My experience backward was five feet – an inch shy the length of my body. Like a whole "me" do over. Five feet might not sound like much – until you've been hugging the side of a slope for a long time. But then you look up toward the top of the mountain, and you just know that your answer is there.
You wonder, though, if you get to the top, if there will be others, like you, waiting. Maybe they started their climb a little earlier or hung around a little longer to enjoy the view.
Illness, wellness…is just like climbing a mountain. You don't know how far you've come unless you pause now and then for reference. When you do, you'll see where you started, the path you chose, where you fell, where you are, how far you've come…Though the journey isn't over, you'll realize that you just might make it. And if that's not enough, you'll realize that if you do, on your way back down you'll pass others halfway up their own climb. You'll encourage them to keep going. You'll become an instructor. If you did it, they can, too. And, they'll believe you.
You know why? Because of the crest. One-point-two miles. Straight up, with the exception of a four-foot zigzag. I stood upright under an Arizona sun. Every cell in me ached. I was dust covered and disheveled, but I had made it.
There was nothing but open space above me, humanity before me, and a firm foundation beneath me. My instructor scrambled up behind me on the breach of the summit. For a moment, there was the flavor of sweet success forged from the journey of only two.
To know, versus to experience, is not the same thing. I turn to find my guide, not scanning the horizon, but watching me weep at the vision. She's already been here – seen it with others – hundreds, maybe thousands of times. But she looks at me, through me, like she's seeing it for the first time – and she is – through my eyes.
I am here because of her guidance. Her words, all along, the answer to my question... is THIS my destiny? Can I do it? A seed here, suggestion there, familiar ground, just enough encouragement for the grip I was in.
There is no one else here – me, my God and my guide. Those who didn't make it – won't even know they missed it. But I would. One last, long look…I would store every pixel of that view in my long-term memory. It would have to be enough for me to describe it to others in words that would give them the will to start the climb.
It is a journey that has taken me eight years and 1.2 miles! Today at the age of 44, I am healthier, happier and have more energy than I have had in all my life! I may not be able to decide the length of my days, but I can do something about the quality of them.
Everybody has a story. Like everybody has a mountain. At least that's my story. What's yours?


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By STEPHANIE BEECKEN6 News Reporter
KNOXVILLE (WATE) - Knoxville police are looking for a suspect in a shooting early Saturday at a Knoxville nightclub that resulted in two people injured.
Police say the shots were fired around 2:15 a.m. at La Rumba Restarurante and Bar, 4900 Chambliss Ave.
Witnesses told officers several people were taking turns rapping inside the club when some patrons began shoving and pushing each other.
An argument then spilled outside the club where shots were fired by at least one man.
Carlos Humberto Porras, 40, and Torie Lavon Brown, 24, both of Knoxville, were both injured with gun shot wounds to their legs.
Police say the suspect fled in a dark colored vehicle. He is described as a Black male, 5-foot-10 with medium build and weighing 160 pounds. He has long dreadlocks.
Carlos Porras was working security at the door when he was shot by stray bullets coming from the parking lot.
"I felt someone pulling at my shorts, and that's when I fell to my stomach and I saw that I had gotten shot," said Porras.
Porras spent two hours in surgery getting metal plates in his leg. He was released Sunday afternoon from the hospital.
"In three or four months I'll be able to walk again. Like I say, it's a lot of pain and I'm trying to do little by little," said Porras.
Saturday's shooting is not the only crime to occur at La Rumba. From January to June of this year, the Knoxville Police Department has received 35 calls for service to the club's address. In the same time frame last year there were 31 calls.
Many calls were for loud noise, some for assaults or fighting.
Mary Sonju lives near La Rumba. She says she is fed up with the activity coming from the club.
"Mostly with a lot of noise. There have been assaults and it seems to be causing problems," said Sonju.
Sonju has lived in the Forest Heights neighborhood for 14 years. She's a member of the Home Owners Association and says the association's officers have met with La Rumba representatives, but no changes have been made.
"It would be wonderful if the establishment could find another place that would be more conclusive to what they want to have going on," said Sonju.
Porras has worked at rumba since November, but isn't planning on returning.
"I doubt I'll go back. Yeah, it's not worth losing your life over," said Porras.
The owner of La Rumba says she has no comment right now. As far as Porras, he's hopeful he'll find another job as soon as he heals.
1306 N. Broadway NE Knoxville, Tennessee 37917
Telephone: 865.637.NEWS(6397)
Fax: 865.525.4091
Email: firstname.lastname@example.com


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Tag: john siracusa
My Dream App voting round 2
The second round of voting is under way over at My Dream App. Vote and let your voice be heard! Plus, when you vote you get a free copy of Mori, Hog Bay Software's document organizer. This round's judges are the cream of the crop of Mac bloggers including John Siracusa of Ars Technica, John Gruber...
WWDC Bingo
John Siracusa is best known for writing in-depth and incredibly geeky pieces about Apple technology. Who knew that in addition to being a hardcore geek John can be a whimsical geek as well (I consider myself to be an uberwhimsical geek. It is a fact that I have never lost my child like wonder)?...
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Pets impounded for violations under the City of Regina Cat and Dog Control Bylaws and are held at our facility. Please visit our facility at Albert St. and Armour Rd. or call 543-6363 ext. 230 if you think one of the impounded animals is yours.
Pets with identification are held for ten (10) days and pets without identification are held for three (3) days. If these pets are not claimed by their owners within this time, they undergo health and behavioral assessments. Animals that are deemed adoptable will then become available for adoption by the public.
Any cat or dog that has been impounded under the cat or dog control bylaw will be subject to an Impound Fee of $35.00. If the pet has identification and is to be held for 10 (ten) days, the owner will be charged board fees of $15.00 for each day starting from the 4th day of impound up to the 10th and final day of the impound period. If the pet has not been reclaimed by the closing of business on the 10th day, it will become the property of The Regina Humane Society.
For example: Mrs. Smiths Bichon "Scruffy" was picked up running in the street and taken to the Regina Humane Society. "Scruffy" was not wearing a collar, nor did "Scruffy" have a tattoo or microchip. "Scruffy" is to be held for 4 days. If "Scruffy" is not licensed and not sterilized, Mrs. Smith will have to pay the following in fines and fees:
Impound Fee: $35.00
Running at Large Fine: $100.00
Failure to License Fine: $250.00
License for adult unaltered dog: $60.00
Total Fines & Fee's owing: $445.00
BUT… If "Scruffy" had been sterilized and had a current license, "Scruffy" would have been eligible for the "Get Out of Jail Free" program, where as Mrs. Smith would have gotten "Scruffy" returned free of charge.
Hwy #6 and Armour Rd. Box 3143Regina, Saskatchewan S4P 3G7Phone: (306) 543-6363 | Fax: (306) email@example.com


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Leanne Watkins
Leanne Watkins
Brighton Department: Ag
As a Senior Account Manager, Leanne leads the agency team to develop actionable, comprehensive marketing and advertising campaigns and strategies, for a variety of Monsanto Company initiatives.
Fun Fact: "I sang at Carnegie Hall with an elite choir at the age of 16."
Cotton Has a New Anthem
by Leanne Watkins on 6.17.2013 posted in Advertising, Company News
Heroes. From actual superheroes, to teachers and parents, we all have at least one hero in our life.
As an Account Manager at Brighton, I have the opportunity to work with many heroes within the agriculture industry. While at times overlooked, farmers across the nation are some of the most generous heroes in the country. read more
Now THAT's Crazy.
by Leanne Watkins on 2.26.2013 posted in Advertising
As professionals in the marketing and advertising industry, we sometimes get wedged into jobs that aren't necessarily our normal, everyday tasks. Would you ever guess, on a Thursday afternoon, that you'd turn the corner at Brighton to find a few of us cutting 5,000 balloon strings? We didn't either, but we took on the task to get the job done. read more


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To Die For
We are just tickled pink! Thanks to our design friends at Pivot Lab, our crackers (packaging that is) made the Dieline-the world's #1 package design website!
Here's a peek at what the Pivot Lab team had to say about our packaging project:
"The simplicity of the design as well as the attention to detail communicates, at first glance, that this is not a typical product…We helped simplify the copy to its purest, most meaningful form communicating the integrity of the product and its creators. In this simplicity we still found room to share Jovan's heart by telling the story of her personal health challenges"
Take a look and read more on Dieline's site.


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GreatSchools Rating
Teacher quality
Principal leadership
Parent involvement
I came to Milestones after teaching in a public school for several years. I needed to find a way out of letting politics run my school and get to a place where I have the freedom to teach the way students really learn. I have found that in this school. I love the entire staff and most of all I love that we are growing leaders in our students. WE as teachers are free to make choices about a child's education and do what is appropriate for each child to learn. As much as one-size fits all education is convenient to fund and easy to train teachers on, it does not benefit the children that need so much more academically. Both to catch them up or equally importantly to advance the children further than expected. At Milestones, I believe we are able to provide a different learning experience for each child and the kids thrive on that. I love teaching here and will never go back to district education again.
Milestones Charter School is both good and bad like all schools. The success of your child does not fall on the shoulders of the staff at the school but yours as a parent. It is your responsibility to work closely with your childs teachers to assure positive growth. A lack of computers and library books does not make the school unsuccessful, most children have access to computers at home and there are public libraries where you have thousands of books to choose from. I found as a parent I simply had to ask and my child received more challenging work, also as a parent when he was slacking I pushed him to do better. The staff has always been polite and courteous however the dress attire puzzled me the children had a dress code, why didn't the staff,? I agree that the play area is in desperate need of work my suggestion is to take the $$ for Jean money and hire a professional ladscaper next year. My oldest son fell behind in public school and caught back up at Milestones he entered high school ready and confident. My youngest son will start middle school in an advance placement program at our local public school. My children excelled yours can too get involved.
Except the reception and the so called principal, everything else is good. Good teachers concentrating on individuals..
My child went to this school because the principal made it sound wonderful!!! Well it was just the opposite, she was bullied all the time!! The teachers didnt take care of it or anything! So the last week of school I pulled her out and when she went back on the last day to get her things the assistant principal/masth teacher got up in her face, and the 7 grade teacher acused her of lying!!! Never again will I refer it to anyone!!!!!
This school has a lot going for it and is a better choice than most public schools. However, it tolerates verbal harassment and abuse and has therfore created a very unkind undercurrent of this behavior that runs rampant in the school.Despite the great reviews (sometimes submitted by the administration pretending to be parents) it is not a school for excelling students. They will tell you each child works at his/her own level, but in reality they all have the same work and the same deadlines and they are geared very much towards the lower standards. It is well suited to children who are a bit slower/behind then those at grade level or ahead. Parents are not welcome at the school.
Milestones is pleasantly diverse culturally. They are very community minded. They attempt to understand the difference in their students and teach them at their strengths and encourage them to excel. Their number one goal is to give the students a safe environment/community. The next goal is to give individualized teaching yet still be in groups/classroom settings. To give an excelling student challenges to succeed, an average student chances to excel, and a challenged student the necessary help to achieve. They try very hard to work with the students and not kick them to the curb if they don t excel to overachieving standards. They keep the whole student in mind and not just tests scores.
I am a student here and it is very cool. I excel in math and other subjects so fast it's crazy.
My 2 kids have been at Milestones for about 2 years now. Overall, we really love the teachers and the other kids/parents. The only downsides: the playground is terrible (wood chips are so disintigrated that the kids are really playing in inches of dirt, not chips. The classrooms are never properly cleaned (and I'm not a neat-freak). Administration is pretty laid-back, a little too much for my taste. I was very disappointed to learn that my daughter was watching movies in her PreK class. That was definitly not on their daily itenerary. Having infant care available on site was invaluable.
When I attended this school I would get good grades but mostly because the work was too easy for me. I didn't feel challenged enough. I also didn't feel welcome in the school. Most students were harsh and others were liars. The teachers didn't discipline students that seemed like a handful. The school lacked a computer room and the library had a little selection of book for children over the age of 9. The school does have a few good points to it. Students are encouraged to be creative. I would say this school is good for average and young students but not much for excelling students.
My daughter is in kindergarten this year and my husband and I are really happy with the school and impressed by her teachers. There is a strong focus on literacy in her classroom and we continue to be amazed with her ever growing reading and writing abilities. Milestones is a really nurturing and caring community where kids come first.
I am both a teacher and a parent at Milestones. Our curriculum exceeds state standards and our children have fun learning. What more could you ask for? We have built a strong community filled with trust, love, and support. Our staff is dedicated to our students' academic and social success. We work a lot in small groups and learning centers in the elementary school. The children get a great deal of individualized attention. We offer wonderful 'specials' classes: Spanish, Art, Music, PE. I hope to see you on the next tour of our school!
Milestones is a wonderful school. There is great communication between teachers and parents. Parents are encouraged to spend time in the classroom for activities like mystery reader and I enjoy that very much. The curriculum is good and the kids are happy. :o)
This is my child's second year here and I was extremely happy with her pre-k teacher. She was beginning to read when she finished. However, they have decided to job share her kindergarten class and the discipline in the classroom has never been acheived. The other concern I have is that there is no PTA and the administration appears reluctant to involve parents in anything but volunteering to help at events. There is no input from parents as to where fundraising dollars should be spent. There are plenty of extra curriculars and the Spanish, Music and Art programs are very good. Cheer, Karate, Gymnastics and various sports are offered after school.
Milestones like any school has its good and bad. There are many extra curricular activities and teachers that care. The administration takes the time to form a personal relationship with the students and parents. The vice principal not only teaches 7th and 8th grade all day but spends time completing other administation duties. She is truely dedicated to this school. Most of the teachers at this school care about their students and work long hours. Does the school lack technology--yes, but I feel they do their best with the funds they receive.
How a school without a computer lab is excelling is most perplexing to me. The computers they have are old and there are only about two per room. Milestone s does not have that many extra activities for students but they do have chess, volleyball, and a school news paper. I also wonder how many field trips the student s experience? The after school pick up in the gym/cafeteria is dangerous and out of control. They put most of the students in there from k-8 and it is chaos. Students run around and throw balls. Smaller students get hit with the balls and also get knocked over. The principal, vice principal and special education coordinator are on a major ego trip and are very controlling. They belittle teachers in front of students and make fun of others including parents. The vice principal is unprofessional as she back stabs and slams dedicated teachers as well as students. The administration does not back up teachers hence the high turn over rate. The older students are well aware that they can manipulate the rules and play the tug of war game between administration and teachers. Some teachers at Milestones are very good but a select few lack couth and enjoy arguing and slamming other teachers in front of students. This school does not prepare students for high school and lacks leadership. I would not recommend Milestones to anyone at all. Not parents, students, or teachers.
I sent my daughter to this school and loved it. That was untill we moved and she transfered to a P.V public school. She was 'Lost'. This school is about two grades behind public schools in the P.V district. (In 4th grade) Parents you are cheating your children out of a good education if you choose this school.She was a straight A student at milestone and is now a C student and struggling to catch up. This is true.
My daughter has been at Milestones for 6 years now and for the last 3 years I have been disapointed. Milestones was a great schools until the founding principal left and all of the students and parents were sad to see her go. Also, all of the really good teachers that challenge the students academically seem to leave after 1 year. I have spoken with several parents who have pulled their children out of Milestones and all of them say that now their children are falling behind in reading, math and even spelling. Why is it that our public schools are teaching at a higher level and require more homework than a school committed to the 'Excelling' education of our children? This will be the last year my daughter attends Milestones and she is upset because she likes the teachers, I just wish they would challenge her academically.
I have always known I wanted to send my daughter to a charter school. I am pleased to say I have NOT been disapointed in the leadership, teachers, and parents that are the community of Milestones. THANK YOU!
I would highly reccomend this School to anyone I know. My son switched from another charter School mid year and is very happy at Milestones. He likes all his classmates and teachers and loves going to school everyday. His teacher Ms. Michelle is amazing. She treats the kids with respect and understands that each child has their own strengths and weaknesses. When we received our sons first report card, we almost fell over. It was a type written three page report on how our son was doing academically as well as how he was doing as a citizen! Communication could be better by using e-mail and through the website but bottom line is that my son is happy and doing well academically.
We just completed a little over half a year in Kindergarten at Milestones before moving to California. Overall, I am very pleased with our experience at Milestones. I am very impressed with the variety of programs (Spanish, art, music, P.E.) even in Kindergarten. I really felt like we were part of a community. Everyone knew my daughter and seemed to really care about her education. We loved Ms. Margot. I liked how there was a variety of cultures and backgrounds in my daughter's class (though that's not up to the school so much). I really think that a lot of the negative feedback here could be from a single person with a bad experience 'stuffing the ballot box' so to speak, and I wish that greatschools would address that problem. I can't speak to their problems, but I know that our experience was a good one.
Community ratings and reviews do not represent the views of GreatSchools nor does GreatSchools check their accuracy or verify the reviewers' identities. Use your discretion when evaluating these reviews.
The Community Rating is the school's average rating from its community members (e.g., parents, students, and school staff). The highest possible rating is five stars; the lowest is one star.
4707 East Robert E Lee Street
Phoenix, AZ 85032
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#iPhone 5S Gold Metal Mastered (Ad)
After the 5c launch, Apple has released its new television spot for the gold iPhone 5s.
Following the same pattern as its budget-friendly model's "Plastic Perfected" television spot, the 30-second commercial records molten-hot gold solidifying into the shape of the iPhone 5s. At the end, a finger unlocks the phone using the new fingerprint scanner feature.
The 5c song choice uses "Rill Rill" by Sleigh Bells, which is consistent with the fun and cheeriness song choice for the "For the Colorful" television spots. The 5s takes a more chic and avant-garde approach, deciding to ironically use "Oh La La" by Goldfrapp.
Are you a fan of the new iPhone commercial?
Test text here
TAGS 5s | advertising | apple | Hashslush | iPhone | marketing | television
5s | advertising | apple | Hashslush | iPhone | marketing | television


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All Schools
(7) All Schools
(7) High Schools
(2) High Schools
(2) Elementary Schools
(4) Elementary Schools
(4) Preschools
(4) Preschools
(4) Public Schools
(8) Public Schools
(7) All Schools
(7) High Schools
(2) High Schools
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(4) Elementary Schools
(4) Preschools
(4) Preschools
(4) Public Schools
(8) Public Schools
There are 7 private schools in zipcode 81301, CO, serving 506 students.
Minority enrollment is 8% of the student body, which is less than the CO state average of 19%.
The student:teacher ratio of 8:1 is lower than the state private school average of 10:1.
81301, Colorado Private Schools
- School Location Students Grades
DurangoChildren''s House Of Durango
1689 W 3rd Ave
Durango, CO, 81301
(970)259-1089Montessori School11 students | Gr. PK-KG
DurangoColorado Timberline Academy
35554 Highway 550
Durango, CO, 81301
(970)247-5898Alternative School26 students | Gr. 9-12
DurangoColumbine Christian School
1775 Florida Rd
Durango, CO, 81301
(970)259-1189(Seventh-Day Adventist)75 students | Gr. PK-8
DurangoDurango Early Learning Center
890 East Third Ave
Durango, CO, 81301
(970)259-1483Alternative School71 students | Gr. PK-3
DurangoFirst Umc Christ Childs School
2917 Aspen Drive
Durango, CO, 81301
(970)247-4213Daycare / Preschool (Methodist)60 students | Gr. NS-PK
DurangoGrace Preparatory Academy Of Durango
1159 E. 3rd Ave.
Durango, CO, 81301
(970)385-7544Special Program Emphasis (Christian)22 students | Gr. 9-12
DurangoSt. Columba School
1801 E 3rd Ave
Durango, CO, 81301
(970)547-5527(Roman Catholic)241 students | Gr. K-9
Zipcode Statistics
|About This Zipcode (81301)
|Zipcode Statistics
|(CO) State Statistics
|Population (Approximate)
|28,308 people
|4,713,654 people
|Age 25+ w/College Degree
|Median Household Income
Recent Articles
Updated August 17, 2014
Getting involved with your child's school benefits both you and the school. It's a win-win for all concerned.
SAT test prep takes time to do properly. We explore some of your options here.
Choosing the right private school for your child involves comparing schools as opposed to ranking them.


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$14 for a Pair of iPhone 5 Style Earbuds with Remote and Mic ($29 Value)
- Deep, rich bass tones.
- Protection from sweat and water.
- Control music and video playback with the built-in remote.
- Answer and end calls.
- Designed to rest comfortably inside, and stay inside, many types of ears.
Buy Details
- Includes a pair of iPhone 5 style earbuds with remote and mic.
- Max 3 per person. Max 3 as gifts.
- Tax included. Expected Shipping Time: 3-4 weeks after the deal ends.
- Shipping Charge: $5 paid at checkout.
- Return Policy: The Purchaser shall not be entitled to any refund.
Expiry Date: No Expiry
What You're Getting:
- $14 for a Pair of iPhone 5 Style Earbuds with Remote and Mic ($29 Value).
- What's in the Box: Earphones with Remote and Mic, Storage and travel case, Compatibility Information.
- The remote and mic are supported by all models of iPod, iPhone, and iPad (not all models support volume up/down functions).
- Audio is supported by all iPod models.
- Requires software version 1.0.3 for iPod nano (4th generation), 2.0.1 for iPod classic (120GB), and 2.2 or later for iPod touch (2nd generation).
How You Get It:
- Purchase your TeamBuy.
- Pay shipping charge and enter in your address information.
- Product will be mailed out to you once offer has closed.
- Products
- Website
We guarantee that TeamBuy is authorized to sell this product and that every brand we sell is authentic.


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News from WTOP
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Mike Causey
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- The 2014 Big Picture on Cyber Security
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Search Tags: Information sharing
Dean of federal CIOs, Van Hitch, to retire
Justice Department CIO Hitch has been in his position since 2002.
Tags: technology , Van Hitch , Justice , information sharing , cybersecurity , Jason Miller
IT is DHS's next challenge for better intel sharing
Homeland Security officials told Congress Wednesday they have made major strides in sharing intelligence information as a matter of policy and practice. DHS also is exploring the possibility of a departmentwide intelligence doctrine. Non-interoperable IT systems, however, remain a major obstacle.
Tags: DHS , Congress , management , information sharing , technology , Caryn Wagner , House Homeland Security , Jared Serbu
Making federal websites more user friendly
Dick Stapleton from HHS and Mark Pietrasanta from Aquilent join host John Gilroy to discuss best practices that federal agencies can use to engage citizens.
May 24, 2011
Tags: technology , Dick Stapleton , HHS , Mark Pietrasanta , Aquilent , Public-private partnership , transparency , Healtcare , Health Resources and Services Administration , Vaccines.gov , information sharing , website design , John Gilroy , Federal Tech Talk , web development , ARMATURE
Risks in increased information sharing
Something your agency is doing to become more efficient could actually be hurting it. Ed Hammersla is chief operating officer of Raytheon Trusted Computer Solutions.
Tags: In Depth , technology , information sharing , Raytheon Trusted Computer Solutions , Ed Hammersla
GAO: DoD can better share biometric info with other agencies
Davi D'Agostino, Director of Defense Capabilities and Management Issues at GAO, discusses the report's findings.
Tags: Davi D'Agostino , GAO , DoD , biometric , information sharing , In Depth
Technology, collaboration advance DoD's mission
Defense intelligence community members and industry peers have come together for knowledge sharing, training and discussion of current and future information technology (IT) challenges and requirements. We get details from Booz Allen's Mike McConnell, the former Director of National Intelligence.
Tags: Federal Drive , DIA , technology , Mike McConnell , Booz Allen , Department of Defense Intelligence Information Sys , DoD , DoD Report , information sharing , collaboration , Osama bin Laden
Information sharing 'instrumental' in bin Laden killing
Information sharing has come a long way since Sept. 11, 2001. This interagency collaboration will be key to military successes, especially as the Defense Department prepares for massive spending cuts.
Tags: Howie Chandler , Air Force , DoD , DoD Report , information sharing , Osama bin Laden , Steve Cooper , DHS
IT sharing solutions tackled at FOSE Conference
Information sharing in the age of WikiLeaks is one of the topics on tap at the annual FOSE Conference.
Tags: WikiLeaks , technology , information sharing , FOSE Conference , KM Institute , Ramon Barquin
Northrop Grumman wins DHS classified networks contract
Tags: Northrop Grumman , information sharing , technology , classified network , contracting , DHS , Ruben Gomez
Agencies still sharing after WikiLeaks
Fears that the leak of thousands of State Department memos to the website WikiLeaks would reverse progress on interagency sharing of national security information have not materialized, officials testified Thursday. Agencies have responded by recognizing the need to protect data rather than by hoarding it, they said.
Tags: DoD , Congress , technology , information sharing , State Department , Director of National Intelligence , James Clapper , Teri Takai , Corin Stone , Patrick Kennedy , WikiLeaks , Joseph Lieberman , Susan Collins , Senate Homeland Security and Governmental Affairs , identity management , secure identity cards , CACs , public key infrastructure , SIPRNet , Jared Serbu


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Isle of Skye, Scotland
Read Shannon's blog "A Little Adrift". Follow @ShannonRTW on twitter.
- - -
"But I had only two months left on my lease and I thought to myself "is this TRULY where I want to be. Not just for another year on the lease, but in my life, am I doing something I love passionately enough to stay." And the answer was no"
Hi Shannon! Thank you for letting me chat with you about your travels today. : )
You're most welcome! Looking forward to it :)
Reading over your blog, one of the posts that really jumped out at me was the post where you talk about why you started traveling when you were 24 in May of 2008 - can you tell me a bit about that moment?
Sure! I was living in Los Angeles at the time, and I had been there for nearly two years.
But I had only two months left on my lease and I thought to myself "is this TRULY where I want to be. Not just for another year on the lease, but in my life, am I doing something I love passionately enough to stay."
And the answer was no - although I loved acting, I had always wanted to travel, I was miserable living with all of the traffic in LA.
I was in some debt from the expenses living in the city, and I already had an internet based job so I made a VERY snap decision after reading the Lost Girls blog to buy a one-way ticket and leave.
I bought the ticket the same week I had my breakdown/revelation.
What did your friends and family think?
My best friend out in LA egged me on, and then hugged me when I *freaked out* 20 minutes later that I had actually bought a one-way ticket!
My dad has always been very supportive, and although he had his reservations about my safety, and that sort of thing, he was on board the whole way.
I joke that he's been my personal assistant as well, I am very fortunate that I am allowed to stay at home between travels, he collects my mail, and handles things when I do something stupid like lose my US debit card : )
lol - I'm sure the post ticket purchase freak out is very common. : )
Oh yes, I think especially if you do it spontaneously like that. A bit terrifying! I still had a whole apartment in LA, no plan, and hadn't told a soul besides my friend about the plan when I booked it!
Very cool - your dad sounds really awesome.
He is wonderful. : )
Thinking back to the person you were in 2008 and who you are today, how has traveling changed you?
I have more time to listen to people. On the road I've learned everyone has a story, it's unique to them, they have hardships, love, and losses. And that's easy to say and easy to dismiss, but really think about that, and when I lived it on the road, meeting other people, it took me further out of my own bubble of self-obsession (which I think we all possess to an extent).
I was very busy with *my* career in LA, now even though I'm further away, in some ways I'm more connected with the people back home because I listen to them more.
Couple that with a LOT more patience and a complete belief in my ability to survive on my own wits, which I know because it's been tested, and I am stronger and more confident now.
What advice would you give to folks who feel the same way as you did in 2008, who are saying "this is not my life"?
If you truly want change, you can live life however you choose. A hiker on the Appalachian trail is quoted as having said something along the lines of "All you need to know is it can be done." He said this in reference to how he travels with nearly nothing, but it goes wider than that. I can't tell you HOW to do it, but it can be done, I did, others have found a way to travel, or change their life in some meaningful way, and knowing it can be done is the battle. The fun part is figuring out how it's going to work best for you!
Which place in the world could you see yourself living in for awhile?
Thailand. I was just living there this spring and I hope to head back there in the fall. Also, foreigners are allowed to buy land in Guatemala, and I've always thought that would be an amazingly lovely place to have a getaway house at some point!
Thailand comes up often as a place many travers would love to live. Why do you think that is?
The quality of life! You can live very well for a small sum of money, and yet you don't have to trade any of the Western conveniences you enjoy. Thailand has US speed internet in many places, grocery stores, and a is *relatively* stable politically, so it's a good bet. A lot of expats are my age, but also retirees head there too.
I did a Thailand Cost of Living breakdown that went viral a few months ago because people were amazed by the value and the lifestyle you can live there.
I've heard that folks in Thailand are incredibly welcoming and friendly.
Thailand bills itself as the "Land of a Thousand Smiles" and it really is true.
Favorite meal while traveling?
Favorite meals get a hat tip to India. I loved nearly every single meal I ate all seven weeks in the country. It was like an orgy of delicious foodiness and I salivate at the thought.
What kind of ingredients were in a typical meal you enjoyed in India?
curries with paneer are a win every time. I'm a sucker for palak paneer, which is finely ground spinach with paneer chunks served with deliciously warm garlic nann to scoop the goopy dish into your mouth.
Oh wow… : )
So tasty!
Sounds like it!
For my last question today…if you could tell the whole world one thing, what would you say?
Do what that you love, the thing that makes you smile to consider, your heart beat a little fast to think about. Do that and be happy.
It sounds like you've done exactly that. : )
Thank you so much for your time this morning!
Thank you too! Good luck with this new site, :) If there is ever anything I can do to help as well, let me know.
Connemara, Ireland.


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Viacom 18 Motion Pictures
14 Viacom 18 Motion Pictures Articles
Manjunath trailer: Viacom 18 comes up with a hard hitting real life story!6 months ago 0
It is the real life story of Manjunath Shanmugham, who was killed by the oil mafia Viacom 18 Motion Pictures is out with the first trailer of… Read Article ▶
Gabbar on the sets: Akshay Kumar's new avatar is hot and hatke! View pics!9 months ago 0
The Khiladi of Bollywood is currently shooting for Gabbar which is the official remake of Tamil film Ramana and here's our take on the pictures from… Read Article ▶
Abhay Deol finds the Midas touch in UK-based producer for an Indo-UK venture10 months ago 0
The Bollywood actor-producer's production house i.e. Films is joining forces with Colin Burrow's UK-based Special Treats Productions to co-produce… Read Article ▶
Yogen Shah
Kangna Ranaut's movie Queen to premiere at Busan Film Festival 201312 months ago 0
The movie, produced by Viacom 18 and Anurag Kashyap's Phantom Films, will have its world premiere at the South Korean film fest Kangna… Read Article ▶
John Abraham: Sri Lanka didn't secretly finance Madras Cafe1 year ago 0
The actor says his film has not been secretly financed by anyone other than his producers Refuting rumours that Sri Lankan President Mahinda… Read Article ▶
Is Prithviraj doing a glorified cameo in Rani Mukerji's Aiyyaa?2 years ago 0
Well, that's what we felt at the Dreamum wakeupum song launch Sachin Kundalkar's directorial debut in Bollywood looks promising. But wethinks Aiyyaa… Read Article ▶
Ajay Devgn: Son of Sardaar doesn't hurt anybody's sentiments2 years ago 1
The film will showcase a very positive projection of the Sikh community, says the actor-producer Actor Ajay Devgn has come out in defence of his… Read Article ▶
GANGS OF WASSEYPUR II: All you need to know about the movie2 years ago 2
Click for pictures, news, gossip, interviews, videos, reviews, features and synopsis The second part of Anurag Kashyap's film Gangs of Wasseypur… Read Article ▶
Salman Khan lends his voice to Akshay Kumar's production 'OMG! Oh My God': watch teaser2 years ago 2
Watch the teaser of Akshay Kumar's film OMG! Oh My God starring Paresh Rawal Salman Khan lends his voice to the teaser of Akshay Kumar's film, OMG… Read Article ▶
Bollywood 2012-13: Which are the exciting movies to watch?2 years ago 0
We have an interesting list of films from one of the leading production houses in India. Take your pick Viacom 18 Motion Pictures has an impressive… Read Article ▶
BLOOD MONEY: All you need to know about the movie2 years ago 1
Click for synopsis, pictures, news, gossip and interviews Kunal Khemu's new film Blood Money, produced by Vishesh Films, releases March 30, 2012… Read Article ▶
'Kahaani' box office report: Rs 7.45 crore on Friday-Saturday3 years ago 1
Vidya Balan's Kahaani has recovered its money and is on its way to being declared a hit After being appreciated for her performance in… Read Article ▶
KAHAANI: All you need to know about the movie3 years ago 1
Click for videos, pictures, news, gossip and interviews related to the Vidya Balan film THE STORY Vidya Bagchi arrives in Kolkata from London… Read Article ▶
Anurag Kashyap to make a film on Sunburn3 years ago 0
The director has partnered with Percept to bring the popular music festival onto celluloid Sunburn - The Movie, a film based on Goa's popular… Read Article ▶
More Viacom 18 Motion Pictures


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Last blog post I posed the question, does LAMP need a successor? LAMP, a software bundle comprised of Linux, Apache, MySQL and PHP, currently powers the web, but due to changes in the way consumers operate online, it's swiftly becoming old-fashioned and too slow for the real-time, cloud and app lovers of today's internet, not to mention expensive to code for, given the today's current expectations.
Meet MoNo-MeLi.
- Mongo replaces MySQL as the database of choice – less of a reporting tool, more of a data/document storage system, but with some nice real-time characteristics.
- Node.js is the new mainstream platform, stunningly fast and good at multitasking.
- Meteor is a small start-up in San Francisco, not even in version 1, but has real potential to tie everything together because it makes it easy for the web to go real-time. Have a look at some of their demos for a quick example.
- And Linux is still in the frame, upping its game to stick with the acronym that powers the internet. Node.js is taking an increasing share of its workload, though.
We threw around a few different acronyms here – LMMN, nSLaMM, nJMM – and MoNo-MeLi (moh-noh-mee-lee) won out in the end.
It builds on the successes of LAMP, while offering improvements in a lot of the areas where users are demanding better facilities:
- It slims down the transactions between web-client and server to a bare minimum.
- This means applications don't have to reload the whole page…
- …and can load in as little as 100 milliseconds.
- The programs require fewer lines of code, meaning shorter development times…
- …and compared to some of the other up-and-comers, there is a lot of online support for these packages.
You heard it here first. One might say LAMP is on the way out, as it does not offer a High Productivity Real-time web. But MoNo-MeLi is ahead of the pack, eager to seize its throne.


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Good morning, SCU Law,
Bundle up, because it's apparently tornado season outside, or so the gale-force winds would lead me to conclude. And check the Grapevine for all the news that's fit to print here (archived here).
Relieve some STRESS with the SBA
1 year ago
You will persevere, it's just another Monday
1 year ago


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Next, you'll be asked to connect with Twitter. Rest assured, we will never send a tweet from your account
without your permission.
We will send you an email with an invite soon.
RT @CoxTV: Great job today, @CMchatLIVE & @JessicaNorthey! Can't wait to see these stars in action on Sunday! #CMChat
SO it's OFFICIAL. now adding "REALITY TV STAR" to my resume.This is gonna be CRAZZZZY!!! #CMchat #ACMs
Make sure u check out our @Google+ #CountryMusic community. Lots of communing, new music & googling going on! #CMchat
RT @keepinitblog: Blake Shelton "Healing in the Heartland" Concert to Feature Reba, Miranda Lambert & Vince Gill #CMchat #oklahoma
RT @loveandtheft: Can I get an "Amen"? | < AMEN & 2 #CMchat
RT @CMchatLIVE: Breakfast of rock stars.
RT @countryweekly: Country stars respond to Oklahoma Tornadoes with words of encouragement and requests to donate to @RedCross
See what's Trending Now for @JessicaNorthey


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Meritline has a great deal on the KingBox K8V1 ATSC Tuner Digital Converter Box. It's $48 – $40 coupon (digital40off) + Free Shipping = $8 Shipped!
Note, you must have a 'valid 2009DTV coupon' – see site for instructions, but it's simple
- Tunes and decodes all hi def TV signals for your regular TV
- Mandatory by 2009
Buy it: KingBox K8V1 ATSC Tuner Digital Converter Box – $8


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Credits & Info
- Uploaded
- Apr 20, 2006 | 4:05 PM EDT
Related Stuff
If you liked this, check these out!
Plenty more like this here!
Author Comments
Sorry for uploading yet another movie so quick, it's the thing with waiting for voice overs, one time you don't have a movie for ages, then a dozen of them are finished in a matter of days. This will be the last movie for a while.
Heh, sorry for a lot misunderstandings with Yugi..oh.. where people got the wrong message that I hate anime, which isn't true ^^: I like a couple of them, but those "kid travels universe to have pets/robots/cards in exciting battles need spoofing.
Concidering I actually watched Pokémon for hte first 3 seasons, this movie will be a lot more right on spot then yugioh.. Wheeeeee!
Rated 5 / 5 stars September 25, 2008
this a brick wall u stupid **********
love dis won two roger
Rated 5 / 5 stars September 23, 2008
you are a great guy, man, a great guy
and your flash - movies are matchless
when I am as far as you in using macromedia flash, i will make the same kind of movies at first xD
Rated 4.5 / 5 stars August 31, 2008
I will give my pokemon away to random people!
WHEEE! i like this video but the game is weird hhahaha
Rated 5 / 5 stars July 18, 2008
i told all of my friends about it
Rated 5 / 5 stars July 17, 2008
this is good
but whats with the game u just walk arournd and if u stay still u still win WTF


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"My Sisters 10th Birthday is coming up and we are having it at bounceinc, and this was this was a perfect card for a bouncing party. Everyone thought the card was cute and loved it. Also great shipping came in 1 week and came in very good quality. Thank You Tiny Prints...!!!"
"Used this card for our daughters third birthday that we were having at a farm. So cute and perfect. The paper quality was excellent, and it is a super fun design. Showed up on our door step ahead of time. Definitely will use Tinyprints again!"
"My kids have birthdays two weeks apart, so we do a joint party and will do so as long as I can get away with it. This was the perfect invitation bc we had the party at a bounce house warehouse. And I was able to put each of their photos on the back--just cuz! Loved it!"
"I bought these invitations for my daughter's 2nd birthday. They are so cute and go perfectly with her barnyard animals theme!"
"I used this card for my son's 1st Birthday party. I was very positively surprised with the quality of paper for $ and already received many complimets from guests on how cute the invitation was."


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Taz Mania
This listing is about Taz Mania in Ipswich, Suffolk.
[ report an error ] Business details
Taz Mania
- Shamrock Avenue
- Ipswich
- Suffolk
- Tel: 01473 680939
[ report an error ] About the company
Taz Mania provide mobile disco hire and are located in Ipswich. For information on hiring a mobile disco please phone Taz Mania on 01473 680939 or visit them at Shamrock Avenue.
Additional links
Please note Bizwiki is neither affiliated with the authors of external sites nor responsible for their content.
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New book on integrated management of the river Cetina watershed
UNEP/MAP/PAP: River Cetina Watershed and the Adjacent Coastal Area: environmental and socio-economic profile. Split, Priority Actions Programme, 2000.
The Priority Actions Programme, a regional activity centre of the Mediterranean Action Plan (the UNEP implementing structure of the Barcelona Convention on the Protection of the Marine Environment and the Coastal Region of the Mediterranean), has recently published the results of an environmental and socio-economic study covering the river Cetina catchment in Croatia and Bosnia & Herzegovina. This study is remarkable for several reasons that are close to some of the Convention on Wetland's main concerns.
Probably for the first time ever, a regional development and planning study links integrated coastal zone management issues with similar approaches covering the relevant hinterland. Starting from the Cetina river mouth on the Adriatic Sea, a particular ecosystem of the adjacent coastal area, that includes significant marine channels and an important archipelago, the study also covers the entire catchment basin of the river. Ecological aspects of water and natural resource management planning, combined with socio-economic aspects and an analysis of the institutional and legal framework are covered. This is undertaken, as far as possible, in a bilateral context, covering both the Croatian and Herzegovina regions covered by the river catchment. The study identifies the pressures on the environment, river-coast interactions and basic elements for the sustainable development of the watershed. It may well become a useful model for regional development planning for shared watersheds and wetlands in other parts of the world, and most notably also for the nearby Neretva watershed, equally shared by Croatia and Bosnia & Herzegovina. The lower Neretva area is currently benefiting from a support by the Ramsar Small Grants Fund.
-- reviewed by Tobias Salathé, Ramsar Regional Coordinator for Europe
Reprint of the book's Foreword
Coastal areas have been recognised as most valuable areas in many countries. Apart from being environmentally sensitive and highly productive, the coastal areas are also attractive for human population and, therefore, for economic development. Sixty percent of the world's population lives within 60 km of the coastlines, and this figure is forecasted to rise to 75% within the next three decades. In order to address a complex natural system and interactions between human activities and natural environment, during 1990s, the need for an integrated approach to coastal area management was recognised. Only in this manner, environmental, social, economic, institutional, financial, legislative and other elements could be identified and incorporated into sustainable development.
River basins have been a unit for management of freshwater resources, which are indispensable for human life, economic development and maintenance of ecosystems. River basin management, originally initiated to address the management of a single resource, freshwater, is now naturally extending its scope to an integrated approach and thus incorporating environmental, socio-economic and institutional elements to achieve multiple objectives.
Recognising the physical, environmental, land-use and socio-economic linkages and interactions between the river basins and associated coastal areas, the Priority Actions Programme Regional Activity Centre (PAP/RAC) of the Mediterranean Action Plan (MAP) and the United Nations Environment Programme (UNEP) initiated a number of joint actions in utilising and protecting resources and the environment of river basins and associated coastal areas in an integrated manner. To this end, the first step taken was the preparation of the "Conceptual Framework and Planning Guidelines for Integrated Coastal Area and River Basin Management", published in 1999 by UNEP and PAP/RAC.
In order to demonstrate usefulness of the Integrated Coastal Area and River Basin Management (ICARM) approach and guidelines contained in this publication, a pilot project was designed for the River Cetina watershed and its associated coastal areas (Croatia and Bosnia and Herzegovina), including the islands in Croatia. At the first phase of the project, the environmental and socio-economic profile of the River Cetina watershed and the associated coastal area has been prepared. Thc Profile was prepared through a series of meetings of experts and was finalised through stakeholder consultations. Thc document reflects a need for all the relevant stakeholders to recognise environmental and socio-economic linkages between the River watershed and the associated coastal area by drawing their attention to possible consequences of the haphazard and unguided future development of the area.
Thc Profile will be followed by an interim document that will assess a number of development options for thc Cetina River watershed and coastal area, particularly with respect to possible future environmental impacts according to the development options. In the final phase of the project, all thc relevant stakeholders would be included (i.e., political actors, state/public institutions, the most important economic actors and thc local population).
We hope that the Profile will succeed to show how the ICARM concept can be actually applied to the specific environmental conditions of thc River Cetina and its associated coastal areas.
Klaus Töpfer
Executive Director
United Nations Environment Programme
Ivica Trumbic
Priority Actions Programme
Regional Activity Centre
Kraj Sv. Ivana 11
P.O. Box 74
HR-21000 Split, Croatia


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Moving on to the next book, The Virgin Suicides. The storyteller is quite an emotional story. Most of the plots are all about war. But I can relate some of the parts in the book with my life and with that reason, I rate this book as 7/10. Thanks to him for the next book.
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