text:
Entinostat and Sorafenib Tosylate in Treating Patients With Advanced or Metastatic Solid Tumors or Refractory or Relapsed Acute Myeloid Leukemia
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01159301
Recruitment Status : Terminated
First Posted : July 9, 2010
Last Update Posted : September 19, 2013
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Adult Acute Basophilic Leukemia Adult Acute Eosinophilic Leukemia Adult Acute Megakaryoblastic Leukemia (M7) Adult Acute Minimally Differentiated Myeloid Leukemia (M0) Adult Acute Monoblastic Leukemia (M5a) Adult Acute Monocytic Leukemia (M5b) Adult Acute Myeloblastic Leukemia With Maturation (M2) Adult Acute Myeloblastic Leukemia Without Maturation (M1) Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities Adult Acute Myeloid Leukemia With Del(5q) Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) Adult Acute Myeloid Leukemia With t(8;21)(q22;q22) Adult Acute Myelomonocytic Leukemia (M4) Adult Erythroleukemia (M6a) Adult Pure Erythroid Leukemia (M6b) Blastic Phase Chronic Myelogenous Leukemia Recurrent Adult Acute Myeloid Leukemia Unspecified Adult Solid Tumor, Protocol Specific
|Drug: entinostat Drug: sorafenib tosylate Other: pharmacological study Other: laboratory biomarker analysis
|Phase 1
I. To determine the maximum-tolerated dose of entinostat in combination with sorafenib tosylate in patients with advanced, inoperable, or metastatic solid tumors.
II. To determine the safety and tolerability of this regimen in these patients.
I. To determine the pharmacokinetic profile of this regimen in patients with refractory/relapsed acute myeloid leukemia (AML).
II. To assess the preliminary anti-tumor activity of this regimen in patients with advanced, inoperable, or metastatic solid tumors or refractory/relapsed AML.
III. To evaluate histone deacetylase (HDAC) inhibition of histone acetylation in leukemia blast cells.
I. To evaluate the expression of downstream markers of drug activity such as p38, MCL-1, FLT-3, and VEGFR-2 in leukemia blast cells.
II. To evaluate SNDX-induced expression of p21^WAF1/CIP1 in leukemia blast cells.
OUTLINE: This is a multicenter, dose-escalation study of entinostat.
Patients receive oral entinostat once daily on days 1 and 15 and oral sorafenib tosylate twice daily on days 1-28 (days 15-28 only of course 1). Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Patients in the expansion cohort undergo blood, bone marrow aspiration, or biopsy for pharmacokinetic studies and biomarker analysis.
After completion of study therapy, patients are followed up for up to 24 months.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|44 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|A Phase I Study of Sorafenib in Combination With the Histone Deacetylase Inhibitor, Entinostat in Patients With Advanced Cancers
|Study Start Date :
|June 2010
|Actual Primary Completion Date :
|September 2013
Experimental: Treatment (entinostat, sorafenib tosylate)
Patients receive oral entinostat once daily on days 1 and 15 and oral sorafenib tosylate twice daily on days 1-28 (days 15-28 only of course 1). Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Drug: entinostat
Given orally (PO)
Other Names:
Drug: sorafenib tosylate
Given PO
Other Names:
Other: pharmacological study
Correlative studies
Other Name: pharmacological studies
Other: laboratory biomarker analysis
Correlative studies
- Maximum-tolerated dose as assessed by the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 [ Time Frame: 28 days ]
- Safety as assessed by the NCI CTCAE version 4.0 [ Time Frame: Up to 30 days ]
- Pharmacokinetic profile of sorafenib tosylate [ Time Frame: At baseline, and at days 15, 16, and 28 of course 1, and day 1 of course 2 ]
- Pharmacokinetic profile of entinostat [ Time Frame: At baseline and at days 1, 8, 15, 16, and 22 ]
- Objective response rate (ORR) based on the best overall response recorded for each patients or according to Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 [ Time Frame: Up to 30 days ]For ORR the 95% confidence interval will be estimated. The 95% confidence interval for percent of patients in each RECIST response category (i.e., CR, PR, SD, and PD) and disease control rate will also be estimated.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
Must meet 1 of the following criteria:
Histologically or cytologically confirmed solid tumors (dose-escalation only)
- Locally advanced, inoperable, or metastatic disease
- Evaluable or measurable disease
Diagnosis of acute myeloid leukemia (AML) for which no other standard therapy, including stem cell transplantation, is expected to result in meaningful clinical response (expansion cohort only)
- Refractory or relapsed disease
- Chronic myelogenous leukemia in blast crisis allowed
- No acute promyelocytic leukemia with t(15;17)
- Must consent to have fresh tumor, bone marrow aspirate, and biopsy obtained
- No untreated, symptomatic, or unstable brain metastases
- No active CNS involvement for patients with AML
- ECOG performance status 0-1
- ANC ≥ 1,500/mm³ (dose-escalation only)
- Platelet count ≥ 100,000/mm³ (dose-escalation only)
- Hemoglobin ≥ 10 g/dL (dose-escalation only)
- Total bilirubin ≤ 1.5 times upper limit of normal (ULN)
- ALT and AST ≤ 3 times ULN (≤ 5 times ULN for liver metastasis)
- Creatinine clearance ≥ 40 mL/min
- Albumin > 3.0 g/dL
- Plasma phosphorus > lower limit of normal (with supplementation)
- APTT ≤ 1.5 times ULN (if not on anticoagulants)
- Able to swallow oral medications
- ≥ 16 years old (expanded cohort patients recruited at the University of Colorado site)
- Must have tolerated prior sorafenib tosylate (dose: 400 mg twice daily), if applicable
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective double-barrier contraception during the study and for 90 days after completion of study therapy
No history of cardiac disease, including any of the following:
- NYHA class II-IV congestive heart failure
- Active coronary artery disease
- Prior diagnosis of bradycardia or other cardiac arrhythmia defined as ≥ grade 2 or uncontrolled hypertension
- Myocardial infarction (MI) within the past 6 months
- Persistent tachycardia
- LVEF < 40% by MUGA
- Second- or third-degree heart block
- QTc > 490 msec
- ST-T wave changes consistent with acute MI or acute ischemia
- No clinically active serious infections defined as ≥ grade 2
- No substance abuse, medical, psychological, or social conditions that may, in the opinion of the Investigator, interfere with the patient's participation or evaluation of the study results
- No condition that is unstable or that could jeopardize the safety of the patient and his/her study compliance
- No known HIV infection
No significant gastrointestinal disorder that, in the opinion of the Investigator, could interfere with the absorption of entinostat and/or sorafenib tosylate including any of the following:
- Significant, uncontrolled inflammatory bowel disease
- Abdominal fistula or gastrointestinal perforation within the past 6 months
- Extensive small bowel resection
- Requiring tube feeding or parenteral hydration and/or nutrition
- No concurrent immunosuppressive therapies, including high-dose systemic corticosteroids (> 0.5 mg/kg/day prednisone or equivalent) unless used intermittently or as a tapered course for ≤ 4 weeks
- Concurrent hydroxyurea and/or anagrelide allowed
- Concurrent warfarin allowed provided the dose has been stable for the past 2 months and INR has been between 2 and 3
- More than 4 weeks since prior chemotherapy, immunotherapy, or investigational agents (=< 2 weeks for leukemia patients in expansion cohort)
- More than 2 weeks since prior palliative radiotherapy
- More than 4 weeks since major surgery
- More than 2 weeks since minor surgery (e.g., talc pleurodesis, excisional biopsy, etc.)
- Concurrent hormonal therapies (e.g., LHRH antagonists, megestrol, octreotide, calcitonin, etc.) allowed
No concurrent strong CYP3A4 inducers or inhibitors, including, but not limited to, any of the following:
- Valproic acid
- Rifampin
- Phenobarbital
- Phenytoin
- Carbamazepine
- Ketoconazole
- Erythromycin
- Grapefruit
- No other concurrent anticancer therapy including chemotherapy, radiotherapy (including palliative), or immunotherapy (except hydroxyurea in leukemia patients during course 1)
- No other concurrent investigational agents
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01159301
|United States, New York
|Roswell Park Cancer Institute
|Buffalo, New York, United States, 14263
|Principal Investigator:
|Alex Adjei
|Roswell Park Cancer Institute
|Responsible Party:
|National Cancer Institute (NCI)
|ClinicalTrials.gov Identifier:
|NCT01159301 History of Changes
|Other Study ID Numbers:
NCI-2011-01435 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
I-165409 ( Other Identifier: Roswell Park Cancer Institute )
8272 ( Other Identifier: CTEP )
|First Posted:
|July 9, 2010 Key Record Dates
|Last Update Posted:
|September 19, 2013
|Last Verified:
|September 2013
Additional relevant MeSH terms:
Leukemia, Myeloid
Leukemia, Myeloid, Acute
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Blast Crisis
Leukemia, Monocytic, Acute
Leukemia, Myelomonocytic, Acute
Hypereosinophilic Syndrome
Leukemia, Megakaryoblastic, Acute
Leukemia, Erythroblastic, Acute
Leukemia, Basophilic, Acute
Leukemia, Eosinophilic, Acute
Neoplasms by Histologic Type
Myeloproliferative Disorders
Bone Marrow Diseases
Hematologic Diseases
Cell Transformation, Neoplastic
Neoplastic Processes
Pathologic Processes
Leukocyte Disorders
Histone Deacetylase Inhibitors
Antineoplastic Agents
Protein Kinase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action


text:
Memorial Sloan Kettering has a longstanding commitment to improving the treatment of gallbladder and bile duct cancer, with the goal of developing more effective, targeted therapies.
A common type of bile duct cancer is intrahepatic cholangiocarcinoma, which begins in the bile ducts within the liver. (For information about primary liver cancer (hepatocellular carcinoma), visit the Liver Cancer information.)
Team Approach to Care
Memorial Sloan Kettering takes a multidisciplinary team approach to providing the best possible diagnosis, treatment, and palliative care for patients with gallbladder and bile duct cancer. Our team includes:
- surgeons
- medical oncologists, who treat cancer with chemotherapy and novel biologic therapy
- radiation oncologists, who use radiation therapy to shrink tumors
- gastroenterologists, who diagnose and treat disorders of the digestive system
- diagnostic radiologists, who use imaging to diagnose diseases
- interventional radiologists, who deliver nonsurgical, minimally invasive therapies
- pathologists, who identify diseases by studying cells and tissues under a microscope
- nurses
- psychiatrists
- social workers
- complementary medicine specialists
- nutritionists
Members of our team meet weekly to discuss the treatment of patients with these cancers, bringing a variety of clinical perspectives and extensive experience to the development of an individualized treatment plan. The team also participates in a weekly meeting to share clinical trial results, review information from surgical pathology reports, and plan future research studies.
Our Publications
Visit PubMed to read journal articles from our gallbladder and bile duct cancer experts
Our doctors are active members of several national and international medical organizations, including the American Society of Clinical Oncology (ASCO), Cancer and Leukemia Group B (CALGB), the American College of Surgeons Oncology Group (ACOSOG), the Radiation Therapy Oncology Group (RTOG), and Society of Interventional Radiology (SIR). Our doctors lead and participate in most national clinical trials to improve the treatment of gallbladder and bile duct cancer. Their research also contributed to the development of the staging classification system for these cancers that is now used by the American Joint Committee on Cancer.
Our Nursing Staff
At Memorial Sloan Kettering, we have a dedicated team of nurses who specialize in caring for patients with gallbladder and bile duct cancer during outpatient visits and inpatient hospital stays. Each nurse works in collaboration with one primary physician to oversee every patient's care. This allows our nurses to asses a patient's needs, triage any symptoms, and if necessary, make referrals to other departments within Memorial Sloan Kettering, such as integrative medicine, nutrition, and social work. Nurses also help patients understand the details of the treatment plan and what to expect throughout the course of treatment. They are actively involved with teaching patients and their families and provide educational materials as needed.
As the liaison between patients and physicians, nurses play an important role in the team approach to care offered at the Center.
Communication with patients and their caregivers is a priority at Memorial Sloan Kettering. We believe that treating the whole person, not just the disease, is best for both patients and their families. Memorial Sloan Kettering offers a broad range of emotional support programs designed to help patients and family members cope with the range of issues related to life during and after cancer treatment. For more information about the services we offer, please visit the After Treatment section.
Individualized Treatment
If gallbladder or bile duct cancer is suspected, the diagnosis may be confirmed through a biopsy, in which a small sample of bile duct or gallbladder tissue is removed and examined under a microscope. Once a diagnosis has been established, additional tests may be required to determine the extent (stage) and precise location of the tumor, which can affect the choice and outcome of treatment. (For more information about the risk factors for developing gallbladder or bile duct cancer, see the Risk Factors section.)
Multidisciplinary input is an important aspect of the treatment plan, since many patients will receive more than one type of treatment. For bile duct and gallbladder cancer, this may include some combination of surgery and nonsurgical treatments such as ablation (removal or destruction), embolization (blockage of blood flow to the tumor), novel biologic therapy, chemotherapy, and radiation therapy. Having a team of specialists collaborating on treatment from the very beginning optimizes patient care.
Our Surgical Experience
Memorial Sloan Kettering's surgeons have extensive experience in gallbladder and bile duct cancer surgery. Our surgeons are continuously working to improve the effectiveness and safety of these procedures, and we routinely offer surgical treatment to many patients of all ages whose tumors are considered inoperable at other hospitals.
Gallbladder cancer is often discovered during laparoscopic removal of the gallbladder to treat gallstones, when the tumor is only partly removed. This greatly complicates the situation and makes curative therapy more difficult. Surgeons at Memorial Sloan Kettering have found that additional, aggressive surgical treatment can improve long-term survival and cure for patients with gallbladder cancer discovered during laparoscopy, including large tumors that have spread to the liver. (1), (2)
Expertise in Minimally Invasive Symptom Relief
Some patients with inoperable bile duct or gallbladder cancer may experience severe abdominal pain. Memorial Sloan Kettering's doctors were among the first to use a minimally invasive technique known as neurolytic celiac plexus block, which involves injecting an anesthetic directly into the nerves that cause abdominal pain. This therapy has been shown to relieve pain level and boost a patient's mood, and life expectancy. It can be performed either during laparoscopic staging of the disease or during evaluation by endoscopic ultrasound — with fewer side effects than conventional approaches to pain management. To learn more about this palliative procedure, visit the Treatment section.
In addition, Memorial Sloan Kettering's interventional radiologists and gastroenterologists are experienced in identifying patients who can benefit from minimally invasive procedures that allow bile to drain out of the gallbladder or through a bile duct that is blocked by a tumor. These procedures are not curative, but can relieve debilitating symptoms caused by a blocked bile duct, such as jaundice, itching, nausea, vomiting, and infection.
Multimodal Therapy for Patients with Advanced Disease
Many patients with gallbladder or bile duct cancer cannot be treated with surgery because their cancer is too advanced. Memorial Sloan Kettering offers a number of treatments aimed at extending survival and improving quality of life for patients with gallbladder and bile duct tumors. Treatment plans may include one or a combination of treatments, including minimally invasive procedures to relieve symptoms, biologic therapy, chemotherapy, and radiation therapy.
Investigational Approaches
Our team of physician-scientists is working to develop novel, targeted therapies that stop cancer cells from replicating or target the blood vessels that nourish gallbladder and bile duct tumors. One study currently underway is evaluating the potential benefits of combining gemcitabine, cisplatin, and sorafenib (a novel biologic drug that disrupts blood supply to the tumor).

subset: commoncrawl


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Six Twin Rivers Artist Association members will exhibit work as the July Artists of the Month at the New Bern-Craven County Public Library in New Bern.
Six Twin Rivers Artist Association members will exhibit work as the July Artists of the Month at the New Bern-Craven County Public Library in New Bern.
The artists include Jan Ebbinge, Cheryl Ashe, Carl Hultman, Beth Conley, Mimi Dixon and Roy Jackson.
An opening reception is scheduled for 7 p.m. on July 11. The public is invited.
Ebbinge said he paints what he knows best � the sea and ocean crafts � from three decades of living and sailing the oceans of the world.
In addition to the untold hours spent in the cockpits of small boats during his 15-year circumnavigation, he lived three years on a Pacific atoll studying the traditional ways of navigation. He learned to �read� the waves in ways unknown to even the most experienced of modern seamen.
His use of color, light and movement in his painting reflect these experiences. Prior to settling in the Bahamasand turning to painting full time, he composed many of his works through the lens of a camera while supporting his travels as a photographer. He is no longer artist in residence on the water in Georgetown, Exuma, Bahamasafter his move to New Bernin April 2012.
Dixon, a local watercolor artist, has been painting for nine years. Her subjects have been the wheat fields and farmland of her Kansasyouth and the coastal and river seascapes of her adult life here in North Carolina.
After completing her teaching career two years ago, she has found more time to devote to her passion.
Ashe calls art her favorite hobby and her mediums of choice are oils and acrylics. She also has painted four standing bears in the New Bernarea.
Conley works plein air and from photographs, working in watercolor, acrylic and pastel.
�I attempt to paint the way light affects objects,� Conley said. �My work in watercolor, acrylic or pastel is an impression or interpretation of what I see and what inspires me about the subject.�


text: A little idea I came up with. A thread where anyone can post a little known fact about Dolphins. I happened to have found a few. 1. The Miami Dolphins are the first team to appear in three consecutive Super Bowls (71, 72, 73) and the first AFL/AFC to win back-to-back Super Bowls. 2. Vonnie Holliday's name is parodied in the non-NFL football game Blitz: The League. One of the superstars in the game, a defensive back, is named Vonnie Treonday. 3. Volume 15 of the manga Eyeshield 21, a picture of Ricky Williams, and his previous dreadlocked appearance may be the inspiration behind a character int he series, Agon Kongo.


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Searched for: author:"Leendertse, W."
(1 - 2 of 2)
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How Can Procurement Contribute to Network Performance? Streamlining Network, Project and Procurement ObjectivesLeendertse, W. (author), Arts, J. (author), De Ridder, H. (author)The core business of governmental organizations like Rijkswaterstaat in the Netherlands is the optimal management of road-end waterway networks. The coming years many maintenance, renewal and extension projects will be executed in these networks. Projects give a disturbance in functionality of the network. Network management is to keep this...journal article 2012
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raditionally, in infrastructure planning, private contractors are engaged at the end of the plan development stage on the basis of a request for proposals, after the conceptual design is finished and the main decisions have been made. They are responsible for final engineering and construction and, separately, for maintenance of the...journal article 2012


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Worldwise Global Schools Grants Round: WWGS aims to increase the engagement of post-primary schools with development education (DE) through a coherent approach that targets post-primary schools...
Relevant Tags: No tags were found.
Start Date: 20/11/2018 End Date: 20/11/2018
Event Location: ILAS Dangan Upper Newcastle Road National University of Ireland Galway, Galway City.
Our final Conversation Circle for this year will be led by Dr Eilish Dillon and will explore How we can make our Development Education more relevant in today's world.
Eilish lectures on a number of courses on the BA in International Development programme in Maynooth University, and has facilitated courses on development and human rights in countries such as Albania, Sierra Leone, Slovenia, Cyprus, Tanzania Russia and South Africa. She has been involved in Development Education and activism on international development issues in Ireland for over 20 years.
This event will take place Tuesday, 20 November, 2.30-4.30pm, in The Institute for Lifecourse and Society (ILAS), NUI Galway.
To register contact: email@example.com
Worldwise Global Schools Grants Round: WWGS aims to increase the engagement of post-primary schools with development education (DE) through a coherent approach that targets post-primary schools...
Briefing on WWGS Grants Scheme: 17th Sept: Briefing on World Wise Global Schools Grant Scheme: 17 September, 2-4pm, WorldWise Global Schools, Knightsbridge House, 17-22 Parkgate Street, Dublin 8.
One World Week Mini Grants Application Process is OPEN!: NYCI is thrilled to announce that the mini grants application process for activities and events related to One World Week is NOW OPEN!
The Role of the Artist is to make Revolution Irresistible: The budget is looming and a group of activists made up of Comhlámh and IDEA members wish to create the space to discuss the issues involved, explore the impact.
Call for Contributors for Policy and Practice Issue 18: The Centre is inviting contributions to Issue 18 of the journal, to be published in Spring 2014 on the theme 'Development Education and Film'.
Funding: European Commission Call Announced: The European Commission has published the Call for Proposals for Non-State Actors and Local Authorities in Development: Raising public awareness of development
IDEA Submission: Strategy for Education for Sustainable Development:
Finding Partners for Collaborative Fundraising: Many funders are welcoming joint applications from organisations. But how do we find partners?
Download and Listen to our Past Webinars: Listen back to all of IDEA's webinars here!
Challenging the Crisis: Host Us For A Workshop!: 'Challenging the Crisis' workshops have taken place in Dublin and Cork during November and December. We would like to thank NYCI for partnering with IDEA
IDEA's Good Governance Project 2014: In 2013, IDEA ran a pilot project supporting member organisations on their journey towards compliance with the Governance Code for Community and Voluntary Orgs
IDEA Submission on CSPE Short Course: IDEA welcomes the CSPE Short Course on Citizenship as an essential opportunity to foreground social justice issues within the formal curriculum...
Recorded Webinar: Choosing and Using Data Collection Tools: Choosing and Using Data Collection Tools. This webinar aimed to build skills in using the most effective tools to measure progress towards your stated goals
IDEA Responds to Government Decision to Abandon Aid Target: The Government has admitted it does not intend to fulfill Ireland's commitments to donate 0.7% of our Gross National Income towards ODA.
Finding Frames - Engaging the Irish public: The Dóchas Development Education Group (DEG) are launching a piece of recently commissioned research.
Young Global Advocates: Our Young Global Advocates in Ireland have met twice and are beginning to look forward to the Global Youth Forum in Brussels in July...
What to learn NOW for the Future We Want: This year, IDEA's Annual Conference asks everyone to consider what we should be learning...
#learnNOW - The Campaign: Ahead of the conference, IDEA wishes to engage the Irish public in conversation around the question of education for a more just and sustainable world.
We Have Moved!: We have a new address and phone number.
IDEA AGM and Conference Over: IDEA held its 2014 Annual General Meeting on the 12th June at Wynn's Hotel in Dublin; the same venue (indeed the same room) where IDEA's first meeting.
5 key points to think about when preparing to apply for the DEAR call.:
About the DEAR Call 2018:
HLPF Day One: Education is the golden thread running through implementation of all 17 SDGs: IDEA Director Frank Geary sharing updates from Day One of the 2018 UN High Level Political Forum on the Sustainable Development Goals
Combating Islamaphobia: 11 May, 2017
WorldWise Global Schools Conference: Meaningful Action: Croke Park, April 2017
Development Education: where we've been; where we need to go: This blog was written by Colm Regan to stimulate discussion at an IDEA Conversation Circle in Dublin, 04 May 2016
Learning about the 'Co' in Ecovillage!:
Youth are the Agents of Change: Rebecca Amet,Young Global advocate with Challenging the Crisis, on the UN Youth Delegate Programme Launch
Closing Time on the "Double Irish": Opinion piece on the OECD's recent announcement about global tax regulation
The Challenge of Learning for a Post-Carbon Future: David Hicks, freelance educator and visiting Professor at Bath Spa University addresses this question in the guest blog below. articles and teaching resources.
What to Learn NOW: How to Make Schools more caring, inclusive places: Dr Gerry Jeffers, lecturer in the education department in NUI Maynooth responds to our question: what should we be learning now to create the future we want?
Together We Stand; Together We Learn: Last weekend, Joe Costello TD revealed in an interview with the Sunday Business Post that Ireland will not meet its 0.7% of GNP target
Citizens of the World? Building global justice perspectives in challenging times: The 2013 IDEA Annual Conference focused on the theme of "Global Citizenship" and considered how we can harness the energy of new social movements.
Development Education - Responding to the Global Crisis?: The DEEEP Seminar "Development Education: Responding to the Crisis?" took place in Dublin bringing together over 100 development education practitioners
LYCS: Facilitating Global Citizenship Education in the Community: 19 & 26 February, and 12,19 & 26 March 2019
WWGS: Transformative Global Citizenship Education: Thursday, 15 November, 2.30-4.30pm, Iveagh House, St Stephen's Green
LYCS: Global Development Course: Deadline for application is 14 September
Job Opportunity: WWGS PROGRAMME DIRECTOR: Deadline for application is 15 July
Cultivate: ERASMUS+ Training on ''Volunteering in Eco-Villages'': 08-12 Oct. Cloughjordan, Co Tipperary
DDCI: Grant Information Session: Monday 09 April, 11.00-12.30, the IDEA Office
Webinar: Digital Global Citizenship: Thursday 29 March, 3.00-3.45pm
Concern: Volunteer & Networking Event: Thursday, 05 April, 6.00 to 8.00
LYCS: Globalisation & Inequality Training: Tuesday, 27 March 2018
WWGS: Annual Grant Application Workshop: 28 March, 2.00-4.00pm in the WWGS Parkgate Street offices, Dublin 8
WWGS: Annual Grant Call: Deadline for application is 09 May
Suas: Facilitators for the Irish Aid Centre: Deadline for applications is 26 March
LASC: Latin America Development Issues Course: Starting Tuesday, 10 April, 6.00-8.00pm, in UCC
LYCS Zero Waste Educator Training: 10.00am-4.30pm, 20 & 21 March
CinC & DDCI: Demysitfying Tax Justice: 14 March, 6.00-9.00pm, St Columb's Park House, Derry
Carraig Dúlra: Designing Solutions Workshop: 07 & 21 March & 07-08 April
LYCS: Sustainable Cookery Course: 5 week course, Mondays, 10.00am-12.30am, 26 February - 26 March
LYCS: Global Active Citizenship through Music: Thursday, 22 February, 10.00am-4.30pm
Comhlámh: Ireland - Development Ally or Tax Haven?: Wednesday 07 February, 7.00pm, Teacher's Club, Dublin 1
DDCI: Stopping the Vultures: Thursday 01 February, 6.30pm, Harbour Hotel, New Dock Road, Galway


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The best thing about standards is that there are so many from which to choose. As Microsoft's Office Open XML (OOXML) format and ISO/OASIS's OpenDocument Format (ODF) battle for industry supremacy, a third contender has emerged from China.
Developed by Chinese software developers, vendors, end users, and academic institutions to promote innovation and interoperability, China's Universal Office Format (UOF) is an open, XML-based format that leverages existing web standards and uses the zip format as a container like ODF and OOXML. At a recent WTO conference in Beijing, Sun chairman and former CEO Scott McNealy called for a merger between between ODF and UOF.
The prospect of merging ODF and UOF is not new. The UOF working group discussed the prospect of "harmonizing" the two standards in 2006, and an OASIS technical committee was assembled to collaborate with UOF developers in an effort to "evaluate the OpenDocument 1.1 specification against the Chinese linguistic, cultural, business, academic, government, technical and similar requirements with special consideration given to how UOF meets these requirements." The committee also worked "to propose other recommendations regarding what steps should be taken for the purpose of harmonizing UOF and OpenDocument."
Is harmonization technologically feasible? Developers and standards experts are convinced that there is sufficient compatibility between UOF and ODF to justify and facilitate a merger. Researchers at Peking University's Open Standards lab have constructed a software utility that can perform complete bidirectional conversion between UOF and ODF—which indicates that the differences between the two standards are very well understood.
The Chinese technology industry often creates its own standards in order to promote domestic business interests and avoid the licensing costs associated with foreign technologies. Since OpenDocument is a completely open standard that imposes no licensing costs on developers, there doesn't appear to be any clear financial incentive for perpetuating UOF as an independent standard. Obviously, a standard created specifically for use in Chinese software has the potential to meet the needs of Chinese users and developers, but with sufficient cooperation ODF could be expanded to meet the same needs. Given the fact that the UOF standard was created—at least in part—for the benefit of Chinese office software developers who have a vested interest in increasing interoperability, it is likely that influential UOF stakeholders will perceive harmonization as an advantageous move. Perhaps pressure from McNealy and others in the ODF community will bring much-needed momentum to the harmonization effort.


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1907—The Only State Geological Survey in a State Constitution
The Oklahoma Geological Survey has the distinction of being the only geological survey written into a state constitution. When Oklahoma became a state in 1907, it immediately became the leader among states in oil production. From the beginning, Oklahoma's natural resources were important to the economy. Legislation mandated that the Survey: Investigate the state's land, water, mineral, and energy resources and disseminate the results of those investigations to promote the wise use consistent with sound environmental practices. The Survey began work in 1908 after an enabling act was signed by Governor Charles N. Haskell on May 29, 1908.
The basic mission then, as now, is research, field work and mapping to add to the body of knowledge about Oklahoma geology and natural resources. The Survey publishes its findings and makes the information available through books, maps, workshops and seminars, lectures, the Internet, and many other means of communication to the public. Among the benefits derived from OGS activities are location and assessment of road and building materials, examination of such natural hazards as earthquakes and ground collapse, water quality and availability studies, information for siting of roads and dams, and studies that aid in exploration for and production of oil and gas.
Along with research and mapping, the Survey makes geologists available to answer questions from the public, speak to schools and scout groups, produce educational materials, and talk to civic groups. The OGS also distributes needed maps and materials from other agencies such as the U.S. Geological Survey.Charles Newton Gould The Father of Oklahoma Geology Director, 1908–1911, 1924–1931
When Charles Newton Gould came to OU in 1900, his drive, determination and relentless energy made him the perfect person to found OU's geology department and, in 1907, to foster in the Constitution what would become the Oklahoma Geological Survey.
Gould saw the need to blend academics, industry concerns and public needs in a single research and public service agency that would bring these areas together to better serve Oklahoma. And that he did, setting the tone for the OGS for at least the next 100 years.
In 1911, Gould resigned to try his hand in the oil business and was a pioneer in the application of geology to exploration. Although he was very successful, he returned to become director of the OGS again when needed in 1924 and stayed until 1931.
Gould is known as the "Father of Oklahoma Geology." Continuing Study of the New State Daniel W. Ohern, Director 1911–1914 Charles W. Shannon, Director 1914–1923
The basic reconnaissance work continued under the next two directors during the early years of the Survey. Investigations of oil and gas, coal, glass sand, building stone, gypsum, lead and zinc, water resources, and building materials continued, while new publications and maps were printed. The first full-color geologic map of Oklahoma was issued in 1926.
It was Charles Shannon who noted that the "need of conservation is apparent to members of the Survey," and pointed to wastes of coal, oil, natural gas, soils, forests and animal life, especially birds. The Survey's directors have been mindful of the mandate to conserve resources and use them wisely. For Daniel Ohern and Shannon, the task was to continue basic studies and expand publication and mapping programs. In 1924, Gould returned. From the Depression to the Jet Age Robert H. Dott, Director, 1935–1952
Dott saw the Survey through the Great Depression, through World War II, and into the beginnings of the space and technology age.
One of his early OGS projects, however, involved people hired through government relief programs in the 1930s to study the culture, building materials and mineral deposits of the state. While the information proved valuable and was put to good use, most importantly a water study of some 100,000 Oklahoma wells, the much-needed jobs helped individuals and the economy. Dott's Survey focused on natural resources suitable for manufacturing and even opened a research lab to develop new uses for some of the most mundane materials, which he called the "humble materials." He hoped Oklahoma businesses would use manufacturing to add value by making pottery, tile, stoneware, brick, drilling mud, glass, rock wool and other products that would result in more money and jobs than simply producing the raw material. Into the Space Age and Beyond William E. Ham, Interim Director 1952–1954 Carl Colton Branson, Director 1954–1967
Bill Ham is the only native Oklahoman yet to be director of the Survey. He was an economic geologist and an authority on carbonate rocks.
Carl Branson's greatest accomplishment as OGS director may have been building up the University of Oklahoma Geology
—continued on back
Dott 100 years 100 years Today, the Survey continues to add library materials through an exchange program with other agencies in the U.S. and abroad. This effort provides publications that are donated by the Survey to the collection of the Youngblood Geology Library.
During his tenure, Branson added a full-time petroleum geologist to the staff and efforts were made to publish more material for oil, gas and coal studies. Uranium also was an item of much interest nationally, and the Survey devoted time to the study of this topic. Charles J. Mankin, Director 1967–2007
During Charles Mankin's years, the OGS became more involved in coopera-tive studies with state and federal agencies and concentrated on oil and gas activities that would help the small producers in Oklahoma.
In 1978, a geophysical observatory at Leonard, southeast of Tulsa, was added to monitor earthquakes worldwide. The Oklahoma Petroleum Information Center in Norman opened in 2002, and in 2006 the OGS officially became affiliated with OU's Mewbourne College of Earth and Energy.
G. Randy Keller, Interim Director 2007–Present
G. Randy Keller, a geophysics professor at OU, came to the Survey to assist in operations after Mankin's retirement. Keller will oversee OGS administrative duties and help the Survey move forward with projects and programs at this time.
The Oklahoma Geological Survey celebrates its 100th year of service to the state of Oklahoma in 2008. It is the only geological survey to be written into a state constitution, an act that highlights the importance of natural resources in this state.
We hope that this very brief overview of the Geological Survey, its history and its directors will help you better understand our mission and our accomplishments.
Please join us in celebrating our Centennial.
G. Randy Keller
Interim Director
Oklahoma Geological Survey
100 E. Boyd, Rm. N-131
Norman, Oklahoma 73019-0628
(405) 325-3031; email@example.com; www.ogs.ou.edu
Mewbourne College of Earth and Energy
The University of Oklahoma
G. Randy Keller
The University of Oklahoma is an equal opportunity institution.
Oklahoma Geological Survey
A brief history
100 years of service to Oklahoma
This publication is printed and issued by the Oklahoma Geological Survey. 200 copies have been prepared and distributed at a cost of $36 to the taxpayers of the State of Oklahoma.
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Instax Leather Case for Fujifilm Instax Mini Camera 8s (Polka Dot Orange)
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Instax Leather Case for Instax Mini Camera 8s
The Leather Camera Case for the Instax Mini 8s is a handsome, stylish and very functional way to carry around your Fuji camera. The case holds the camera vertically with the lens protruding through a custom cut out behind the front flap. Snaps hold it closed in the back. The included shoulder strap makes transportation easy.


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The title for the 2013 Tidal Graph Calendar produced by and available from the Barataria-Terrebonne National Estuary Program is "Traditional fishing techniques of South Louisiana."
The title for the 2013 Tidal Graph Calendar produced by and available from the Barataria-Terrebonne National Estuary Program is "Traditional fishing techniques of South Louisiana."
Each year BTNEP produces a Louisiana-flavored, full-color calendar that highlights the estuary's unique ecology and history, and additionally depicts, graphically, the daily tides for coastal Louisiana.
This year's calendar theme showcases traditional fishing techniques employed in south Louisiana. Beginning with a short summary of "fishing then and now," the calendar covers a new aspect of Louisiana's fisheries each month.
Here is the breakdown of topics by month:
January: Bigorneaux poling and bush lining.
February: Crab lining.
March: Drop netting.
April: Fish trapping.
May: Shrimp trawling.
June: Angling.
July: River shrimp trapping.
August: Cast netting.
September: Paupiere fishing.
October: Gill netting.
November: Seining.
December: Oyster tonging.
Copies of the calendar can be obtained by contacting BTNEP at 447-0868 or stopping by their office on the Nicholls State University campus, 320 Audubon Drive, Thibodaux in Room 105 N in Babington Hall. It is also available for download from their calendars site at www.btnep.org/BTNEP/resources/downloads/calendars.aspx.
"Established in 1991, the mission of the Barataria-Terrebonne Estuary Program is the preservation and restoration of the Barataria-Terrebonne estuarine system, the 4.2 million-acre region between the Atchafalaya and Mississippi River basins," the calendar says. "The BTNEP strives to rebuild and protect the estuary for future generations through the implementation of a science-based, consensus-driven plan that utilizes partnerships focused on the estuary's rich cultural, economic and natural resources."
For information about BTNEP, visit their website at www.btnep.org/BTNEP or "Like" them on Facebook at www.facebook.com/BTNEP.
A Louisiana fisheries summit for the Louisiana commercial fishing industry, "Louisiana Fisheries 2013," is scheduled for Feb. 27-28 at the Houma-Terrebonne Civic Center, 346 Civic Center Blvd.
Topics to be covered at the commercial fisheries summit include professionalizing the fishery, history of the fishery, economic status, legislative update, the oyster hatchery program, blue crab research updates, seafood promotion and marketing, sustainable seafood and certification programs, Gulf Seafood Trace program, Gulf Council updates, TEDs update, social media, micro-branding, Louisiana Direct Seafood, the Louisiana Seafood Academy and more.
The seminar is produced by the LSU AgCenter's Louisiana Sea Grant Program and is free and open to the public, however, due to limited accommodations and resources, pre-registration is required. Early registration is available at bayoulog.com/events. Registration by phone begins Jan. 3.
Additionally, officials with the LSU AgCenter are planning a "Dock Day" scheduled for March 1. The event will feature on-board demonstrations of innovative handling and processing equipment and techniques.
Alan Matherne is the LSU AgCenter's area fisheries and coastal issues agent for Terrebonne, Lafourche and Assumption parishes. He can be reached at 873-6495 or firstname.lastname@example.com. You can read his articles and blogs at bayoulog.com. Friend him on Facebook at facebook.com /profilephp?id= 100001785563037 and follow him on Twitter @amatherne.


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Alright, it's time for some updates. The last two and a half months on Clearwater have been incredibly full. Lots of beautiful sailing up and down the Hudson, visits to the city, a festival here and there, and lots of teaching. I can't believe it, but my contract is more than half over, and my planning for next steps is in full swing.
I found out while I was in Tasmania that I'm eligible for what they call a working holiday visa. I didn't know about this visa when I went. Everyone should know about this! If I had I'm sure I would have applied for it and worked (rather than volunteered) during my time there. This 12 month visa is available to people with undergraduate degrees up to and including the age of 30, and allows them to seek temporary employment, spending no more than six months in each job. The idea is to facilitate cultural exchange between participating countries by making it easier for young people to visit.
So, with a partner in Tasmania, a closing window of eligibility for this visa, and some Tasmanian qualifications, I'm planning on returning to the apple isle again in the New Year. My most exciting prospects for jobs in Hobart are working on a sight-seeing boat as a tour guide, running boats at a fish farm, and working on research vessels for UTAS or CSIRO, Australia's national science agency. My goals for my next job are to get a lot of experience handling a small boat, or work on a boat with some scientific overlap, be it field observation or research.
Hopefully Iain and I will also have time to do some travel around the mainland, see some of the outback and the great barrier reef…maybe even another trip to New Zealand? A transit by sea is of course also in the world of possibilities. Right now I'm still in the planning stages, but I'm getting excited for a return to such a beautiful place.


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In response to the coming era of Internet of Things (IoT), the TS-653A innovatively supports the open-source Linux platform as a gateway for IoT solutions to other smart devices. The TS-653A allows users to directly utilize various feature-rich Liunx apps, enjoying a private cloud combining storage and IoT applications, and professional developers can develop and run IoT applications directly on the TS-653A. The secure, reliable TS-653A is packed with business-critical features such as Volume/LUN Snapshot - allowing files/folders to revert to a previous state in case of any corruption or file-loss. The TS-653A is powered by the latest quad-core Intel Celeron processor which allows users to enjoy 4K (H.264) video playback and 1080p/4K video real-time transcoding directly from the TS-653A to an HD/4K display.
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U.S. Equal Employment
Opportunity Commission
Security Company Fired Employee for Wearing Religious Head Scarf, Federal Agency Charged
PHILADELPHIA – A Philadelphia-area security company will pay $50,000 and furnish significant equitable relief to settle a federal religious discrimination lawsuit, the Equal Employment Opportunity Commission (EEOC) announced today.
The EEOC charged that Imperial Security, Inc. failed to accommodate the religious beliefs of Julie Holloway-Russell, who is Muslim, and terminated her instead. Holloway-Russell wore a khimar, religious garb which covers her hair, ears, and neck, as required by her religious beliefs, when she interviewed for the job of security guard. However, when she reported to her first work assignment wearing her khimar, she was told to remove it. Holloway-Russell respectfully refused to do so because her religious beliefs mandated that she wear the religious head covering.
The EEOC charged that by failing to modify its dress code to allow Holloway-Russell to wear her khimar and instead terminating her, the company violated federal law.
Title VII of the Civil Rights Act of 1964 prohibits discrimination based on religion and requires an employer to reasonably accommodate an employee's religious beliefs, including modifying dress codes, unless doing so would pose an undue hardship. The EEOC first attempted to reach a pre-litigation settlement before filing suit in United States District Court for the District of Pennsylvania, Civil Action No. 2:10-CV-04733.
In addition to the monetary relief to Holloway-Russell, the three-year consent decree resolving the lawsuit contains important remedial relief, including prohibiting Imperial Security from further discriminating based on religion or engaging in unlawful retaliation. Imperial Security will designate an EEO officer who will receive complaints of discrimination or retaliation and revise its employee handbook to permit accommodation of religious beliefs. The company will establish a procedure for handling any complaints of discrimination and a disciplinary policy for any employee who engages in discriminatory or retaliatory behavior. The company will also provide annual training on Title VII to all employees, report to the EEOC regarding how it handled any complaints of religious discrimination or retaliation, and post a remedial notice.
"The 21st century workplace is increasingly diverse," said EEOC District Director Spencer H. Lewis, Jr. "The resolution of this lawsuit should remind all companies of their legal obligation to provide a reasonable accommodation of an employee's religious beliefs."
Regional Attorney Debra Lawrence of the EEOC's Philadelphia District Office, which oversees Pennsylvania, West Virginia, Delaware, Maryland, and parts of New Jersey and Ohio, added, "We are pleased with this settlement. In addition to the monetary relief, the settlement provides significant measures, including the naming of an EEO officer and the adoption of policies and procedures to address discrimination complaints. These injunctive measures should benefit all employees."
The EEOC enforces federal laws prohibiting employment discrimination. Further information about the EEOC is available on its web site at www.eeoc.gov.


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The Cults as Theological Judgment
Writing early in the last century, J. K. Van Baalen argued that "the cults are the unpaid bills of the church." Van Baalen's influential work, The Chaos of the Cults, represented one of the first comprehensive efforts to evaluate …Read More
Cults 'R' Us
There are any number of ways that cultural confusion always walks down the aisle with relativism. Divorce, in this instance, isn't an option. If, for instance, we all agree that there is no such thing as right and wrong, then …Read More
Modern Cultic Tendencies
Since the nineteenth century, the U.S. has proven to have a cultural soil that is particularly well-suited to the growth and spread of diverse cultic movements. The nineteenth century alone witnessed the rise of numerous small cults as well …Read More
The Cult of Personality
Religious liberty is one aspect of American life that almost every citizen of the United States cherishes. Common is the pastoral prayer in any Protestant congregation that includes gratitude for the liberties that Christians enjoy, which permits them to worship …Read More
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From time to time I get a knock on the door from two exuberant representatives of one of the local cult chapters. Although such visits have become less frequent in recent years, it is generally my practice to step outside …Read More


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Eurozone turning Japanese and what it means for the EUR
The Eurozone is looking increasingly Japanese with consistently low GDP growth rates and plummeting inflation levels, which implies the EUR faces upward pressures like JPY once did. Eurozone inflation is running around 0.8% and the region is barely expected to grow 1% a year. In the short-term the main culprit for low growth is austerity and the brutal process of wage and cost adjustments within the peripheral Eurozone countries. They became chronically uncompetitive in the run up to 2007. But longer term there are some worrying parallels with Japan. Europe is getting older and quite quickly. According to Eurostat those aged 65 years and over will account for 29.5 % of the EU-27's population by 2060, compared 17.5 % in 2011. Meanwhile, the working population is likely to decrease steadily sapping Europe's growth potential while increasing medical and retirement costs. Japan is way ahead. Nearly a quarter of its population is 65 and over and that will rise to 38% by 2055. Not only that, but the country's population is actually shrinking. The previous governor of the Bank of Japan Masaaki Shirakawa blamed the ageing population for low growth and warned that the West was on a similar path. But a steadily less dynamic Japan, endowed with high living standards and deflation saw JPY getting steadily stronger until Abenomics was introduced to very deliberately put an end to that trend.
The grey currencies – EUR/JPY
ECB can't do QE The Eurozone is very close to drifting towards deflation and unlike Japan, US and UK has a deeply constrained central bank. Though the European Central Bank has done some clever manoeuvres to provide liquidity it cannot do outright quantitative easing. It's simply not allowed to do it. If Japan, US and other major economies all manage to generate some inflation and keep interest rates very low – there will be growing pressure over the long-term for EUR to appreciate and this could pose a problem for the ECB and the recovering Eurozone members in terms of exports. And the real reason why deflation matters is not so much about delayed consumption – older people are more into needs-based consumption – it is about debt. Japan has a debt to GDP ratio of 230% and at some point it will cripple the country unless it is paid down or inflated away. With a shrinking population the former is not possible. As Europe gets older it will face the same dilemma. However, unlike Japan, the Eurozone is a union of sovereign countries pursuing independent fiscal policies. So as economic pressure points shift within the zone it is likely to trigger intermittent bouts of concern and even crises, which will undermine the EUR when they occur.
By Justin Pugsley, Markets Analyst MahiFX
Follow MahiFX on twitter @MahiFX


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Elmore Leonard populated his novels with con men, hustlers and killers, with names like Chili, Stick and Ordell. He plunged readers into a sea of urban sleaze, spiking his tales with mordant humor and moral ambivalence.
In stories often set in Detroit or South Florida, he betrayed a love for down-and-out characters and pitch-perfect dialogue. A line from his novel "Be Cool" makes a point in typical Leonard style: "`Chili Palmer's a talker,'" Nick said. " 'That's what he does, he talks. You should've hit him in the mouth.' "
Leonard's dozens of novels and short stories helped raise the genre of crime fiction to a literary level, winning a global audience and inspiring such popular films as "Get Shorty" and "Out of Sight."
The author died Tuesday at his Bloomfield Township, Mich., home. He was 87 and had suffered a stroke three weeks ago.
A bearded, slightly built man who looked a little like everyone's favorite English professor, Leonard held dear a personal list of rules for writing: Never open a book with weather, keep your exclamation points under control, and if it sounds like writing, rewrite it.
"If proper usage gets in the way, it may have to go," Leonard wrote in 2001. "I can't allow what we learned in English composition to disrupt the sound and rhythm of the narrative. It's my attempt to remain invisible…"
The author who aimed to keep his writerly presence out of his prose started his career with a string of Westerns, some penned in early morning sessions before his day job as an advertising copywriter in Detroit.
In Hollywood, most of his stories were optioned or bought for films or TV shows, most recently the FX series "Justified."
"You have to put him up there with the greats, like Jim Thompson and James M. Cain," screenwriter Robert Towne told The Times in 1995. "His stories have an economy of language that gives his dramatic situations an incredible sense of ballast and gravity."
Director William Friedkin went even further, telling The Times in the same article: "Nobody who writes crime fiction is even in the same league with him."
Leonard was newly married when he launched his literary career in 1951, moonlighting as a writer of western short stories for the then-thriving pulp magazine market.
His first western novel, "The Bounty Hunters," was published in 1953. Four more of his western novels were published over the next eight years, while two of his short stories were being turned into movies — "The Tall T," starring Randolph Scott; and "3:10 to Yuma," starring Glenn Ford (and remade in 2007 with Russell Crowe).
After the market for westerns dried up in the 1960s, Leonard switched to writing contemporary crime novels, the literary genre that made him a worldwide critical favorite and earned him fans ranging from Nobel laureate Saul Bellow to President George W. Bush to director Quentin Tarantino.
Beginning with "The Big Bounce" in 1969, Leonard turned out dozens of crime novels, including "Mr. Majestyk," "Swag," "Gold Coast," "Split Images" and "Stick." His 1983 novel "La Brava" earned him an Edgar Allan Poe Award from the Mystery Writers of America.
But it wasn't until "Glitz," his 1985 novel about a psychopathic ex-con who wants revenge on the Miami Beach cop who put him behind bars, that Leonard cracked the prestigious New York Times bestseller list.
Time magazine dubbed the then-59-year-old author "The Dickens of Detroit," an unabashedly alliterative accolade that the self-effacing Leonard once wryly dismissed by asking, "Do you think if I lived in Buffalo, I'd be Dickens?"
On why his novels sold so well, Leonard simply would say: "I leave out the parts that people skip."
Despite the popularity of his novels among filmmakers, Leonard was seldom pleased with the results. Until it came to "Get Shorty," the hit 1995 film adapted from his acerbic novel about Miami loan shark Chili Palmer (John Travolta), who arrives in Hollywood to collect a gambling debt and winds up becoming a movie producer. The film, directed by Barry Sonnenfeld and written by Scott Frank, "had my sound. I could hear my characters on the screen," Leonard said.
Tarantino, who based his 1997 movie "Jackie Brown" on Leonard's novel "Rum Punch" and optioned several other Leonard novels, has acknowledged "owing a big debt to Leonard."
"He helped me figure out my style," Tarantino told Playboy in 1995. "He was the first writer I'd ever read who let mundane conversations inform the characters. And then all of a sudden — woof! — you're into whatever story you're telling."
Leonard was well aware of what he was up against when it came to Hollywood adaptations of his work.
"Everyone has always had trouble telling if my stories were straight drama or comedy," he said in the 1995 Times story. "In this town, all they want to know is: What's it about? All they want is the story. But what I do well is what happens between the story. The talk, the characters.
"I start with people, get them into situations — and see what happens. I send Chili Palmer to Hollywood and then I start thinking — does he become an actor? No, maybe he's a studio executive or a producer. I never plot my books out."
As Friedkin observed: "Elmore's insights come from his narrator's voice — that's the real pleasure of his stories — and that's hard to translate on screen."
Leonard was born in New Orleans on Oct. 11, 1925. His father worked for General Motors, scouting car dealership locations around the country. His family moved to Texas, Oklahoma and Tennessee before settling in Detroit in 1934.
In high school, where he played football and baseball, a fellow student gave him his lifelong nickname, "Dutch," after Washington Senators pitcher Emil "Dutch" Leonard.
It wasn't until he was majoring in English and philosophy at the University of Detroit after serving in the Naval Reserve in the Pacific during World War II that Leonard began writing short stories.
Leonard married his college sweetheart, Beverly Cline, in 1949, and they had their first child within a year.
After graduating in 1950 he landed a job at Campbell-Ewald Advertising in Detroit, where he wrote advertising copy for Chevrolet. He also began writing short fiction for magazines on the side. He chose westerns, he said, "because I liked western movies."
His first published story was "Trail of the Apache" for Argosy, a men's magazine, in 1951.
With his full-time job as a copywriter and a growing family, Leonard realized that the only way he could write fiction was to rise at 5 a.m. Sitting at the living room coffee table, he'd spend two hours trying to write two pages on a yellow tablet.
"I made a rule that I had to get something down on paper before I could put the water on for the coffee," he said in an interview published in "The Complete Western Stories of Elmore Leonard" (2004). "Know where you're going and then put the water on. That seemed to work because I did it for most of the '50s."
"The Bounty Hunters" was published in 1953. In 1960, armed with $11,500 from Campbell-Ewald's profit-sharing plan, Leonard quit with the intention of writing full time. Instead, he bought a house and, with a wife and five children to support, spent the next few years writing freelance advertising copy and educational film scripts for Encyclopedia Britannica.
In 1966, however, 20th Century Fox bought the film rights to his 1961 western novel "Hombre," which became a 1967 movie starring Paul Newman. That gave Leonard enough money to write his first non-western novel, "The Big Bounce."
For many years, Leonard wrote screenplays to support his crime-novel writing. Among his numerous film credits: "Joe Kidd," starring Clint Eastwood; "Mr. Majestyk," starring Charles Bronson (Leonard wrote the screenplay for the 1974 film before writing it as a novel) and "Stick," starring Burt Reynolds (based on Leonard's novel).
While his writing career was booming in the early '70s, his marriage was crumbling and he was drinking heavily. In 1974, the year he moved out of the house, a friend suggested he try Alcoholics Anonymous.
"I got into drinking because I was shy, somewhat introverted, self-conscious, and it brought me out. It was the macho thing to do," he told Playboy in 1995. "I drank from the time I was 16 until I quit when I was 52. And I had more fun when I was drinking than at any other time."
In 1979, two years after his divorce, Leonard married Joan Shepard, who helped him during his alcohol withdrawal and read and critiqued his writing before it went out. She died of lung cancer in 1993.
Less than a year later, he married Christine Kent, who was in charge of the gardening crew that tended to his yard. They divorced in 2012.
He is survived by his five children from his first marriage, 13 grandchildren and five great-grandchildren.
When he was working on a novel, Leonard wrote every day — in his living room with a No. 5 Pilot Pen on unlined yellow paper before typing the handwritten pages on an IBM Selectric.
Writing novels, he said in 1998, is "the most satisfying thing I can imagine doing. To write that scene and then read it, and it works ... there's nothing better than that. The notoriety that comes later doesn't compare to the doing of it. I've been doing it for almost 47 years, and I'm still trying to make it better."
McLellan is a former Times staff writer.
Times staff writer Steve Chawkins contributed to this report.


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Tom Dorr, senior adviser to the Secretary of Agriculture, came just short of saying traditional farm programs have outlived their usefulness during his keynote address at the Southwest Crops Production Conference and Expo in Lubbock recently.
Dorr said farmers may need a better way to manage their business than by following a "seven decades old" farm program. He cited financial management and leadership expert Peter Drucker's formula for a successful business model.
"Drucker said the most crucial aspect of management must be to understand what the customer wants and then determine how to meet that demand. He also said innovation and entrepreneurial activity" are key elements in business management.
Dorr said a business plan lasts about 10 years. "After that, we have to start all over. Seventy years ago (the U.S. Government passed) the first agriculture support act. And farmers and ranchers have been following that same business plan for seven decades."
Dorr said the time from 1964 through 1979 was a "golden period for agriculture." Increased demand for food and fiber followed the economic boom after World War II.
"A series of crises from 1979 through 1984 extracted the excess liquidity from the economy," he said.
He said weather and economic cycles currently threaten the agricultural economy. "But we've initiated a number of policies to help." Dorr said the farm bill enacted in 2002 had a significant impact on farmers, as did tax cuts.
He said conservation initiatives in the most recent farm legislation, as well as in previous programs represented society's "distinct interest in how we manage our resources."
That interest, he said, holds "significant implications for production agriculture."
Dorr said the next farm program will be written by new legislators, most of whom will not represent rural America. Population shifts have moved the sphere of influence into suburbia, he said.
"The year 1990 marked the first time that 50 percent of our population lived in the suburbs," he said. "In 1994, the leadership positions in the U.S. Congress came from suburban districts. In 1999, only 76 congressional districts were rural and in 2000 most American lived in the suburbs."
That erosion of rural voting strength affects agriculture. "Their (suburban dwellers) interests are significantly different from rural issues."
Dorr said agriculture will survive through technology and moving to value-added products.
"Renewable fuels, for instance, is an industry that has arrived. It's not in an experimental mode. It is here and it will stimulate rural America."
Dorr said farmers and ranchers must not use their resource base carelessly. "Farmers must use those assets to leverage value-added opportunities."
He said ethanol would provide opportunities to take advantage of rural resource bases.
Dorr said as the population dynamics and markets change and trade issues become more important, farmers can't rely on "a seven-decades old business model. But the entrepreneurial spirit is as bright (in the United States) as it has ever been. Very few countries have ever had an entrepreneurial spirit."
e-mail: firstname.lastname@example.com


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Aside from being able to log on and view the forum, I am unable to
1, contact anyone (attempts lead to login loop)
2, log a cache (attempts lead to log in loop)
I can now see many caches on c:geo but log nothing. Very frustrating. Have reported issue previous but..


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The official Muskerry RFC app
Ellis Park Ballyanly Inniscarra Co. Cork 000 000 View with Google Maps
This website is part of the Pitchero Rugby Union network. Create your own free Rugby Union club website with Pitchero.
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Mod Edit:
You CAN'T link from the imageshack page where the photo is. I suggest using Imgur. It's simple, quick, and easy, and allows easy direct image linking. Plus, it automatically does thumbnails for you
Please be respectful when posting. Do not insult others. Remember to follow all forum rules when posting here. This is not a chat thread. Please refrain from overly sexual comments, from bating others, and from general creepy-ness.


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Home / Academics / Special Student Populations / Foster Care and Student Success
Foster Care & Student Success, housed in Texas Education Agency's Division of Federal and State Education Policy maintains resources and information to advance the education of student's impacted by foster care. The resources and materials provide guidance related to the unique circumstances surrounding students who are in the foster care system and attend Texas public schools. In Texas, nearly 16,000 school-age students are in foster care at any given time.
The Foster Care & Student Success web content is divided into the following areas:
TEA developed a premiere resource to support Texas schools in addressing the education of students in foster care: Texas Foster Care & Student Success Resource Guide (PDF). This guide is the product of collaboration with the Texas Department of Family and Protective Services, the Supreme Court of Texas, and the Permanent Judicial Commission for Children, Youth and Families (Children's Commission). This e-guide and training manual contains a variety of key researched-based topics and calls attention to important matters related to the education of students in foster care. The guide promotes best practices and contains numerous tips, tools, resources and links to more information.
TEA desires that the guide be widely used and distributed! Please share with your districts, schools and networks. The guide is available in a variety of formats.
You can download the complete resource guide below:
Individual chapter downloads are also available:


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LOS ANGELES, July 20 (UPI) -- Handsome leading man known for his roles in The Rockford Files and The Notebook, James Garner, died Saturday at his home in Los Angeles, police said. He was 86.
Police, who were called to Garner's home Saturday night, said he died of natural causes.
Garner had a notable career in both television and the big screen. He starred in TV's Maverick in the 1950s, The Rockford Files in the 1970s and most recently played the grandfather in Eight Simple Rules for Dating My Teenage Daughter.
His film career included roles in The Children's Hour, The Great Escape, Victor Victoria and Murphy's Romance.
Kaley Cuoco Sweeting, who worked alongside Garner in Eight Simple Rules, took to Twitter on Sunday to express her sadness at his death.
I say this with a heavy broken heart.was an honor working beside u receiving ur bear hugs every day. ❤ u Grampa Jim pic.twitter.com/twYRUG6w0B— Kaley Cuoco Sweeting (@KaleyCuoco) July 20, 2014
Garner is survived by his wife, Lois Clark, and their two daughters, Kim and Gigi.


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LOS ANGELES — Spanish-language radio host Eddie "Piolín" Sotelo is getting his own channel on SiriusXM, three weeks after Univision canceled his long-running show amid sexual harassment allegations.
"Piolin Radio" will launch later this year. Sotelo will anchor it in a four-hour morning drive call-in show from Los Angeles, the satellite radio service announced Aug. 13, 2013.
"'El Show de Piolín' will include lively discussion of the day's events, surprise interviews with celebrity guests, listener call-ins, pranks, music and much more," SiriusXM said.
Sotelo, whose nickname means "Tweety Bird," said in the statement that he "can't wait to fly free and for the first time be truly available coast-to-coast."
SiriusXM is hoping that Piolín will draw subscribers and advertisers as it expands its Spanish-language lineup to reach a growing Latino audience, said Scott Greenstein, SiriusXM president and chief content officer.
Sotelo, who was recently elected to the National Radio Hall of Fame, played corny jokes and pranks on his morning drive time show but also hosted politicians including President Barack Obama to discuss issues such as immigration reform.
After a decade on the air, however, Univision abruptly canceled Sotelo's radio show last month after a Univision employee alleged that Sotelo had sexually harassed him. Sotelo has denied the allegation.


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IT WAS almost summer holidays again, the crickets were chirping at dusk and the seven special friends had found themselves in an exciting adventure. They'd been hauled before New South Wales' Independent Commission Against Corruption.
Day after day, a horrid gang, the Learned Friends, were taunting them with beastly accusations. Geoffrey, the meanest of the Learned Friends, kept saying they were fibbing. He kept making them remember silly things that had happened long ago.
If you haven't met the Secret Seven, there are three sets of best friends: Travers "Trav" Duncan and Brian Flannery, John McGuigan and John "Atko" Atkinson, and John "Kingy" Kinghorn and Greg "Jonesy" Jones – and an investment banker Richard "Digger" Poole just for good measure.
The Seven had hatched a brilliant plan. They got their hands on a New South Wales coal licence for $1 million and almost sold it for $500 million. That was after the Mines Department mysteriously got five different letters from five different companies linked to the Seven asking to be allowed to tender. Anyway, after all that to-do, Cascade Coal emerged with the licence.
Suddenly one day, although nobody knows exactly when, they found this fellow Obeid lurking about in Cascade. What a shock! If "unethical" journalists from The Sydney Morning Herald, as Kingy calls them, found out more about this they might write "tripe" and spoil their plans to sell Cascade to White. Then they wouldn't be able to get richer. Well, things were going swimmingly until this goody-two-shoes from White, Graham Cubbin, started asking silly questions about Cascade. Graham was an independent director of White and seemed to be taking his job of representing White's little shareholders a little too seriously.
Ghastly fellow he was, a real pest. "We just got to get there first," Kingy confided in a phone call to Jonesy intercepted by ICAC, "then we'll chop the arsehole's head off."
The lads were no strangers to adventure. Indeed, after telling Geoffrey he would dob him in to the Law Council for fibbing, Kingy reminisced for a moment about the good old RAMS adventure. Ah, those were the days, after his Allco adventure, when he'd sold RAMS home loans to that silly old sharemarket and taken a splendid $500 million in cash just days before the global credit crisis. He would give those Learned Friends a piece of his mind.
THERE were 1000 gems in the ICAC cross-examinations this week, and there will be many thousands more before Eddie Obeid even gets in the box. We have selected a few, readers, for your edification.
Geoffrey Watson, counsel assisting the commission, to John Kinghorn:
"It wasn't anything to do with the
fact that Greg Jones had a previous relationship with Ian Macdonald [mines minister] was it?"
"I've heard you allege that and that is utter tripe."
"Utter tripe?"
"Utter, utter tripe. Rubbish, rubbish."
"A lie by me?"
"I think it was a bit of a fabrication by you, yes, because you actually said you had evidence to this effect and I do not believe you do have evidence to that effect."
Watson to Kinghorn about a meeting of Cascade shareholders:
"So you attended a meeting and voted on an issue of 717,000 shares to Coal and Minerals Group [a vehicle set up to distance Cascade from Obeid] without having even any idea as to why that was being done. Is that what you're telling us?"
"At that point in time, correct."
"And have a look at the price that was being paid … for the shares: 9.3 per cent of the capital of Cascade Coal was being sold for one ten-thousandth of a cent per share, do you see that?"
"I do."
"Well, surely you asked the question about that?"
"Yes, I did."
"At the meeting?"
"No, I did not."
"Right. You sat there at the meeting thinking, 'Good God, they've just given away … 60 million, yeah, $60 million of value?"
"So you just sat there and just thought, 'Dear me, they've just given away $60 million for $71.78'. Is that what you thought?"
"It certainly piqued my interest and I wanted to find out what it was about."
That bit of testimony is typical. The entire proceedings are spiced with it: misunderstandings, foggy recollections, lack of curiosity, dumbfoundedness, emails received but not read; and this from seven people worth collectively more than $1.5 billion.
Let's close with Winners and Losers so far.
Losers: the Secret Seven – they sustain reputational damage and have no deal, though Poole probably got some banking fees. Likewise, Brent Potts and his "Lost Arc" clients have dusted $28 million in the White placement though Pottsie probably got his 5 per cent.
Winners: the Obeids are still up $30 million and there is no smoking gun, yet.
Real winners: the incoming Liberal government in NSW earns big points for a rise in ICAC's funding.
Graham Cubbin can stand tall. A real independent director, doing an admirable job.


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I have been hauling nail polishes a lot recently – I love collecting them but I really can't be bothered applying it most of the time – when they make drying times 1 minute or less, then I'm game. Otherwise…I just end up staring at every imperfection. I do it to other people…if you see ever see someone glaring at your nails in the lift, it's me, it's totally me.
I bought 2 cool chunky glitter polishes from Missha recently – they're called The Style Crystal Polishes, and apparently consist of 20% glitter!
It comes in purple, orange and blue. I went against expectations and bought orange and purple!
I do like glitter polish because a dummy (aka. me) can apply it and it will still look nice…
It's a pain to get off though – it goes right through me trying to take it off.
Here are the bottles. Quite lightweight but stylish. The lids look like hearts from a birds eye view:
Korean brands have loads of really nice and interesting polishes, I've realised. I'd totally recommend looking at Missha, Skinfood and Tony Moly for some cool colours and textures.
These polishes come with chunky brushes – quite thick and coarse hair and slightly thick textures.
I like thick brushes – the sooner the damn thing is applied, the better. I don't have a problem using Missha's although this is a glitter polish and is easy to apply:
Purple is nice it's very…purple.
Orange is like a copper:
Brush is wonky as you can see.
This works well as a top coat although I can't think what to put orange on top of – what do you think?
These reminds me of the fun Hexogram polish from Barry M.
Anyway – I think I prefer fine super shimmer to this chunky stuff. Maybe I'm just growing up but this polish reminds of a rash, and not a good one, more of a itchy scabies type rash. Wow I am delirious. Can polish do that to you?
I bought these from eBay for about £7 each.
Chunky glitter, yay or nay?


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Attractive, right... Hmm, well moving on. There have been some confusing rumors revolving around Zayn Malik, from the band One Direction. Although I can't confirm it 100%... I can confirm it on a basis I guess. Although he was seen wearing a cross, I can guarantee that Zayn is a Muslim. I saw a video when he was having dinner on the X-Factor, and he says he's eating "special chicken" which in my opinion means "halal", right? Anyway, here's some other proof:
Zayn Malik participated in Ramadan this year, where Muslims fast (don't eat/drink anything) from when the sun goes up and then it goes down again. I did it too. Anyway, on the first day, Zayn tweeted "First rosay tday , who's fasting?". I'm guessing he meant to say "first day" or...? Here's that tweet.
tweet from an Islamic Twitter. The sentence was in Arabic. He then tweeted a translation, saying "la ilaha ilallah w muhammed rasoolalah." Here are those tweets:
|Click to make it bigger.
P.S Malik means King in Arabic.
PP.S His Twitter is 100% him. Twitter accounts are only verified if that person is the real deal and not a poser. The actual Twitter administrators take care of that and you can't become verified unless you're famous. A blue circle looking thing with a white tick in the middle means someone is verified. And also, One Direction and all the band members are also verified. @Harry_Styles @NiallOfficial @Real_Liam_Payne and @Louis_Tomlinson


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Union High School held its Graduation Awards and Honors night on May 18, at the high school auditorium. Many deserving seniors received scholarships and honors. Those presented with awards were:
Erica Barz
La Porte City Lions Club*
Community Foundation
American Lutheran Women*
Best of Class
National Merit Scholarship
Simpson College
National Student Athlete Award
Outstanding Senior Vocalist
Outstanding Speech
Army Scholastic Award
Blake Clark
La Porte City Women's Club*
Red Smit Outstanding Golfer
Dick Ballheim Outstanding Male Athlete
Alissa Clark
Union Booster Club*
Rainsford and Ann Brown Memorial Scholarship presented by Standard Forwarding
Katelyn Damro
Dysart 20th Century Women's Club*
Laikyn Davis
Hayle Davison
La Porte City Police Dept.*
Leah Earney
Outstanding Senior Artist
Casey Ewald
Cecil Glenn Teeter Book Scholarship*
Dysart Fine Arts Women's Club*
Ashley Frush
Advocare "We Build Champions"*
American Bar Association
Ken Paulsen Outstanding Female Athlete
Benton County American Legion Aux.
East Central Iowa REC
Trowel Lodge #216*
Marine Corps League
Wendy Heisman Recognition
Aly Garwood
La Porte City Lions Club
Norma Anders Scholarship
Grand Lodge of Iowa
Dysart General Women's Club*
Des Moines 2011 Academic All-State
High School Woman of the Year-Tama County
Central College
Waterloo Elkets Scholarship
Emily Getz
Mabel R. Brown Memorial*
TJ Gray
Cornell College
Marine Corps Distinguished Athletes
Abby Hager
Steve Rolland Memorial, Lions Club
La Porte-Dysart FFA Scholarship
Robert Hadachek Agricultural*
Kelsi Hilmer
Ascalon Masonic Lodge Scholarship
Owen Hix
Marion and Dorothy Lutz Masonic Scholarship
Centennial Club Scholarship*
Skye Houchin
Kenneth G. Meyerhoff Memorial
Wells Fargo Bank*
Taylor Kugel
Wayne and Neva Leo Scholarship
Ed Bader Memorial*
Tiffany Kuhn
Union Education Association*
Jaden Ludwig
Matt Memorial Scholarship*
Kirk Mahood
LPC Chamber of Commerce*
Cerena Merchant
Hawkeye Community College
Mercedes Morris
Michael Reed Family Memorial*
Jordan Olson
Haley Peters
Wartburg College
Outstanding Senior Band
Jake Reiter
St. Catherine's Circle*
Miranda Riechmann
Dr. Albert C. Hindman*
Katey Samuelson
Iowa Soybean Association
Dysart Lions Club*
Chad Odette Memorial*
Kline Families Scholarship in Ag
Paige Sears
Marine Corps Distinguished Athlete
Brad Siebel
Bernie Saggau Award
Better Business Bureau
Army Scholar Athlete
Robert Swestka
Cedar Valley Bank and Trust*
Joey Ternus
Dysart American Legion
Dysart Farmer's Coop Telephone
Nathan Vaughn
Ron Borton Scholarship (Anton Farms)*
Catherine Wigg
Kristi Struve Memorial*
Pipho Family Dentistry*
Seth Woodson
Mary Wrage
Govnernor's Scholarship Recognition
Benton County American Legion
Ellis Jones Academic Scholarship*
*Union Community Scholarships