text: The Original Pritchard Teat Flutter Valve Nipple, introduced by sheep ranchers in New Zealand, is the best nipple we've found for feeding weak or newborn kids. The soft red rubber teat is perfect for the kid to suck. Plastic base screws onto 28 mm glass or plastic bottles (disposable pop bottles, etc. -- a very common size). A metal bearing "valve" inside the nipple lets air flow in smoothly but controls milk flow. Since the nipple won't drip, kids are less likely to choke. Excellent for kid-feeding for the first five days or for weak kids. Keep several on hand for starting newborns. Also available in bulk.


text:
Looking for design inspiration? Browse our curated collections!
Semi by Barbara Keith - 8" x 10"
Archival Matte Paper
Rolled in a Tube
Assembly Charge
Semi poster by Barbara Keith. Our posters are produced on acid-free papers using archival inks to guarantee that they last a lifetime without fading or loss of color. All posters include a 1" white border around the image to allow for future framing and matting, if desired.
Ships Within
2 - 3 business days
Congratulations!! This beautiful image has been selected to be featured for the week in the "Art Forever With You" Group Home Page. You are welcome to add a preview of this featured image to the group's discussion post titled "2018 May: Stunning Group Featured Images and Thank-you's" for a permanent display within the group, to share this achievement with others. If the activity is allowed, your image will also be posted to our group Google+ page. Thank you for your participation in the group! ~Jan
Barbara Keith replied:
Thanks for the feature Jan and will do
Thanks for the feature Jim (A-Z of Black & White Art)
Thanks for the feature Beth
Thanks for the feature Lenore
Thanks for the feature Jannice
My pleasure, Barbara.
thanks for the feature Jack
Wonderful drawings Barbara. Thank you for joining and contributing to "Black Rules"!
All prints ship in durable cardboard tubes.
Pixels is one of the largest, most-respected giclee printing companies in the world with over 40 years of experience producing museum-quality posters and prints. All of our posters are produced on state-of-the-art, professional-grade Epson printers.
We use acid-free paper with archival inks to guarantee that your posters last a lifetime without fading or loss of color. All posters include a 1" white border around the image to allow for future framing and matting, if desired.
Posters ship within 3 - 4 business days in durable cardboard tubes.
Average Rating (4.93 Stars):
Mary Harmston
June 26th, 2019
Roger Werksman
June 25th, 2019
Bill Miloglav
June 25th, 2019
Melanie Smith
June 24th, 2019
When you're looking for something to do on scratchboard, the ideas are many but the references are few...this is one of those experiments that I couldn't resist.
05-19-17: Due to the injury of my index finger I can no longer work the hours I used to so I'm working on very short timelines. What that means is that it's going to take me a lot longer to get anything done. You never realize how important a thing like a finger is until you damage it!!! Bear with me, I will post anything new as I finish them. Also, I would like to let all the groups that I belong to know that I'm trying to catch up on everything - considering I lost about a year in total where I really couldn't do much. Sorry for the influx. 07-07-16: Will be absent again due to a torn tendon in my right hand (index finger). Will be gone for at least 8 weeks 04-09-16: I just want to let every one know that I will probably be absent...
Our return policy is very simple:
If you're not happy with a purchase that you made on Pixels.com, for any reason, you can return it to us within 30 days of the order date. As soon as it arrives, we'll issue a full refund for the entire purchase price. Please note - Pixels does not reimburse the outgoing or return shipping charges unless the return is due to a defect in quality.
Pixels sells thousands of pieces of artwork each month - all with a 100% money-back guarantee. We take great pride in the fact that hundreds of thousands of artists have chosen Pixels to fulfill their orders, and we look forward to helping you select your next piece!
All posters ship from our production facility within 2 - 3 business days of your order.

subset: commoncrawl


text:
Tipping Guidelines for Cruisersby Paul Motter | 12.22.11
While some cruise lines are all-inclusive, most others expect passengers to reward gratuities according to proper cruise etiquette.
Tipping Guidelines for Cruisers
I write a regular cruise column for a large news organization, and I recently asked my readers to send me cruise questions. What I discovered is that I often forget that most people know far less about cruising than I do. So, once in a while I like to write a basic article for people with just rudimentary cruising experience. More experienced cruisers may find things in there they forget or hadn't considered as well.
This week I want to talk about proper tipping etiquette on cruises.
It is often said that cruises are "inclusive" vacations, but that term has very specific meanings in the travel industry, and while most cruises are "inclusive" only a few select cruise lines are "all-inclusive." On most cruise lines you have to pay separately for alcoholic drinks and for gratuities for your servers and other crewmembers.
Holland America
Sail & Save Event on NOW! Reduced Airfare and free upgrades. See ALL Holland America Specials here.
Holland America
You are expected to tip your (1) room steward, (2) waiter, (3) the Maitre D' and (4) the busboy. In the old days we actually brought cash for tips with us and stuffed four envelopes at the end of the cruise. Some cruise lines still expect you to do that.
The funny about that is this, however. They still take all of the cash and divvy it out as they see fit anyway. So, why go to all the trouble to separate it?
American Discount Cruises & Travel
Onboard Credits, Reduced deposits, Upgrades and E-coupons w/up to $400 Savings! Book a 3-night or longer NCL cruise to qualify. Expires 12/18/11. American Discount Cruises & Travel
Most cruise lines have now streamlined the tipping procedures by simply adding a certain amount (about $10 per passenger per day) to your shipboard account. This covers all of your gratuities and you don't have to do anything else to make sure all of your servers are covered.
Now, you should know a few details. First of all, when you sign for a drink, a massage or any other service, in most cases a service charge has already been added, anywhere from 10 to 18-percent. But the ticket will include a blank space for you to add an "additional gratuity."
Why tip twice? There is really no reason to give them an additional tip beyond the service charge already included.
Celebrity Cruises the Caribbean
Caribbean cruises now officially on sale! From just $289 per person.
Celebrity Cruises
On the other hand, there may be a time when you feel someone went beyond the call of duty for you. If you want to tip them then do it discretely in cash, in your stateroom where no one can see you, or some other quiet place. Remember that ships have surveillance cameras everywhere, and all employees who receive any gratuity are supposed to share it with the pool of tips, but if that is not your intention then tip your intended discretely.
CruiseMates Cruise - Europe 2012
Sail on the Brand New Carnival Breeze on a 14-day cruise from Barcelona to Italy starting at $1499 per person. Carnival Breeze 2012
Finally, first-time cruisers, watch out for crewmembers giving you a sob story about needing money. I have heard stories about crew members being "adopted" by passengers because they feel sorry for them. The cruise lines do not approve of crewmembers telling the guests personal stories about how much they miss their kids and how they are only working full time on the ship because they need to send the money home.
In fact, that is probably true of most of the crewmembers on board, but it is also true that they are well-paid compared to what they would normally make working in their home countries and there is no reason to feel sorry for them.
Be sympathetic, but don't be a sucker.


text:
Unless you have cable in the middle east, you have to put up with regular free to air satellite channels that either air Arab crap, or a few English channels which all air the same movies and shows over and over and over.
Even newer seasons of shows air a few years after they were shown in the USA (CSI is up to it's 12th season in the USA but here they've only aired up to 9). Hell there are even shows that have never aired on any Arab channel and never will (Wilfred & Game of Thrones are good examples of shows that will never see the light of day on free to air channels). And even the shows that make it end up getting censored. Grey's Anatomy has all the Calizona scenes censored out, so unless you've watched the uncut episode, sometimes you stare at the TV and wonder WTF because you didn't understand what just happened when the scene was cut half way through, why, because Callie smiled at Arizona, or hugged her, or held her hand.
This is why I download all my shows, I like to watch the latest episode right away and that episode being uncensored is a huge bonus.
I have a bunch of summer shows, so I don't get bored during the big hiatus and long wait until it's Fall and all my shows are back, but what does one do during winter hiatus where there are no shows at all to watch? Well I for one get addicted to new shows (like I don't have enough to watch already).
This year I decided to give a few new shows a try, and a few old ones, which I downloaded while I was in Dubai last November. The first show I watched was Unforgettable (all 11 episodes), it's still in its first season, and the reason I wanted to give it a try was because Poppy Montgomery was in it (if you remember she was Sam in Without a Trace). I can honestly say that the show is awesome and I really really hope CBS renew it for another season.
The second show I watched was Ringer (all 10 episodes), I've never liked Sara Michelle Gellar much, I really hated her in Buffy, but I'd seen part of the Ringer pilot on TV and I got hooked.
What really caught my attention was that this show was different and the suspense does keep you on the edge of your seat. It's about Identical twin sisters Bridget & Siobhan, estranged for the last six years find that their lives are both unraveling at the same time. Bridget, a recovering addict, is on the run from the mob after witnessing a murder. She flees to her sister's home & they seem to be repairing relationship until Siobhan mysteriously disappears during a boat trip the sisters take together.
Then I had to choose between The Big Bang Theory (all 5 seasons) and Doctor Who (all 6 seasons and the specials). Since I wasn't that optimistic that I'd like Doctor Who even though I'd promised a friend I'd give it a try (I hate science fiction, I hate aliens, I do like time travel though, and I hate it when shows keep changing main actors every few seasons) so I decided to go with The Big Bang Theory. I'd watched a few episodes on TV and I loved it. I started to watch on a weekend and I couldn't stop, I think I ended up watching one season a day. I finished it in less than a week.
And finally I was left with Doctor Who, I've been watching for almost 2 weeks now and I'm almost half way through the final season, I should be done watching it by tomorrow.
I'm so glad I left the best till last, I'm totally hooked, I honestly can't stop watching, I spent the last 2 weekends in bed watching one season a day. I stay up till 2am on weekdays after I get home from work watching, every time I finish an episode I promise myself the next one will be the last for the night…it never is.
And yes, I'm writing this blog post while I watch episode 5 of Doctor Who's season 6, it's actually the first kinda boring episode so it doesn't need my full attention…yet.
I may review Doctor Who in a future post, if I ever get around to it…it really is that awesome and deserves one.
Hiatus is now over, actually has been over for a week now and I have a bunch of new episodes of my shows to watch (over 18 hours worth) but I can't until I'm done with The Doctor.


text:
Miguel Chicas never saw "The Carol Burnett Show." At 21, he's a bit too young to have been around for the Saturday night variety show that ran from 1967 to 1978, but when his old high school drama coach invited Chicas to partake in such a show, he jumped at the chance.
Miguel Chicas never saw "The Carol Burnett Show." At 21, he's a bit too young to have been around for the Saturday night variety show that ran from 1967 to 1978, but when his old high school drama coach invited Chicas to partake in such a show, he jumped at the chance.
"When I first saw (a tape of) 'The Carol Burnett Show,' it was nice to see some of the few tap dancing sequences," Chicas said. "It was nice to see that on TV. That's what this show brings. It will be nice to see a family-oriented show, a happy show."
"This show" is "A Showbiz Christmas," written and directed by Kevin Costello, who owns That's Showbiz on the Miracle Mile, with his wife, fellow actor Elizabeth. The variety-style show with skits and musical numbers runs today through Sunday and Dec. 21 to 23 in the basement of That's Showbiz, 1744 Pacific Ave.
"It's fun, fun, fun," Kevin Costello said. "It's a show for the whole family, with singing, comedy skits, some improv, a little dancing, some tap dancing. It's a throwback to the old variety shows, Carol Burnett, even a little 'Saturday Night Live,' but in a family setting."
The lower-level space at That's Showbiz will serve as the cabaret/black box theater. Guests will sit at small tables in an intimate setting. Seating at each show is limited to 75 people.
"It was always a hope: What if we could do it by Christmas?" Kevin Costello said of plans to include performances in the family business that consists of a movie/theater collectables shop and acting classes. "We were toying with the idea for a couple months of renting another space, but we said, 'We're paying rent here. Let's make it happen.' "
Out went the set for the Stockton Civic Theatre production of "Sweeney Todd," which had been sitting in the theater space, and in came tables and chairs. Brian Johnson, SCT's technical director and set designer extraordinaire, built a platform stage, and had previously convinced the Costellos to paint the walls black. They've added Christmas decorations and lights and are ready to stage a holiday show.
"I actually saw the space before I was asked to do the show," said Janelle Chaney, 23, of Lodi. "The minute I walked in I said, 'This is amazing.' I was in awe, and I started thinking about how good he is, because I saw his shows at St. Mary's, and knew he would make good use of the space. The first day I walked in to do this show, it was much, much more than I expected. I don't think the audience will expect this."
The show was written by Kevin Costello, who directs St. Mary's High School productions and starred as Sweeney Todd, but has a love of writing.
"I've written a couple comedy skits," Costello said. "I put it together, but the cast is collaborative in rehearsal. If people come up with ideas, we listen to them."
Kevin Costello's ideas include a skit that finds Santa's reindeer in therapy for various reasons, which Chaney said is hilarious, and a Tim Conway-Harvey Korman-type skit about a slow, old man in a shop whose tempo is a great inconvenience to a man trying to quickly finish his Christmas shopping."
He also penned new lyrics - parodies - of Christmas songs.
"The cool thing about this show as a performer is it's really collaborative," Chaney said. "There's a nice openness, almost casualness in the way he brought everything about. Kevin came up with the script and emailed it to everyone. He put us in parts he thought we'd like and they were all perfect. They matched everyone fantastically."
The light comedy pieces reflect "his personality," as opposed to the darker "Sweeney Todd," said Chicas, who was one of Kevin Costello's drama students at St. Mary's.
The Costellos invited Chicas to join them in the cast along with Joy Clark, also a St. Mary's graduate, her mom, Janet Clark, Chaney, Joaquin Lewis and Jacob Bronsan, who have been active in local theater, mostly Stockton Civic Theatre.
In addition, each performance will have a special guest star. Scott Minor, an SCT actor in such shows as "Run for your Wife" and "The Best Little Whorehouse in Texas," performs tonight; Randy Linee, who starred opposite Kevin Costello in "Sweeney Todd," performs Saturday; and Sarah St. Pierre, SCT's Cinderella, appears Sunday.
Lydia Merriam-Pigg, who just wowed audiences as Betty Haynes in SCT's "White Christmas," performs on Dec. 21; Thomas Costello and Liz Eradi, who played the young lovers Marius and Cosette in St. Mary's production of "Les Miserables," reprise "A Heart Full of Love" on Dec. 22; and musician Paul Kimball will sing and play the French horn on Dec. 23.
Chaney, a classically trained singer and pianist, will sing "Oh, Holy Night" with Janet Clark. She also enjoys the improve Christmas party scene, and the reindeers-in-therapy skit.
For Chicas, a voice student at Delta College, the holiday show provides a unique opportunity.
"My favorite moment is when I get to do a scene with Kevin," Chicas said. "I was never able to act with him, and I always wanted to. To have a chance to work with him as an actor is really fun. He does things, and you try not to laugh on stage."
Contact reporter Lori Gilbert at (209) 546-8284 or email@example.com.


text:
NOAA National Weather Service Fire Weather Experts Assisting In Australia
Fire weather forecasters from NOAA's National Weather Service are on duty in Australia providing crucial weather information to forecasters in the Australian Bureau of Meteorology as they battle wildfires ravaging southeastern Australia. NOAA's National Weather Service and the Australian Bureau of Meteorology agreed in 2006 to exchange fire weather expertise and staff during the U.S. and Australian wildfire seasons, which occur at opposite times of the year in the Northern and Southern Hemispheres. (More)


text:
1. heat - noun
· a form of energy that is transferred by a difference in temperature
Synonym(s): heat_energy
Hypernym(s): energy, free_energy
2. heat - noun
· the presence of heat
Synonym(s): hotness, high_temperature
Hypernym(s): temperature
3. heat - noun
· the sensation caused by heat energy
Synonym(s): warmth
Hypernym(s): temperature
4. heat - noun
· the trait of being intensely emotional
Hypernym(s): emotionality, emotionalism
5. heat - noun
· applies to nonhuman mammals: a state or period of heightened sexual arousal and activity
Synonym(s): estrus, oestrus, rut
Hypernym(s): physical_condition, physiological_state, physiological_condition
6. heat - noun
· a preliminary race in which the winner advances to a more important race
Hypernym(s): race
7. heat - noun
· utility to warm a building; "the heating system wasn't working"; "they have radiant heating"
Synonym(s): heating_system, heating_plant, heating
Hypernym(s): utility
8. heat - verb
· make hot or hotter; "the sun heats the oceans"; "heat the water on the stove"
Synonym(s): heat_up
Hypernym(s): change, alter, modify
Antonym(s): cool
9. heat - verb
· provide with heat; "heat the house"
Hypernym(s): supply, provide, render, furnish
10. heat - verb
· arouse or excite feelings and passions; "The ostentatious way of living of the rich ignites the hatred of the poor"; "The refugees' fate stirred up compassion around the world"; "Wake old feelings of hatred"
Synonym(s): inflame, stir_up, wake, ignite, fire_up
Hypernym(s): arouse, elicit, enkindle, kindle, evoke, fire, raise, provoke
11. heat - verb
· gain heat or get hot; "The room heated up quickly"
Hypernym(s): change_state, turn
Antonym(s): cool
The only site you need for word puzzles, home work, anagrams and scrabble games. The best site for two word anagram solutions.
Enter the letters to get anagrams for the word
Definitions, synonyms, antonyms and related words
Enter the word below with '?' to indicate missing letters
Enter the word to find the rhymes
Enter the letters of the beginning, middle or end of the word.
Unscramble.net is the free tool to unscramble letters and words for games like Text Twist, Words with Friends, Scrabble, Word Scraper, and of course the ever popular Jumble newspaper puzzle. It is also great for homework problems that frustrate many parents and students. Unscramble.net provides one and two word unscramble solutions from its extensive 280,000 word list that includes technical, medical and slang words. There is no limit to the number of letters entered for one word unscrambles and the site also provides for rhyming words and dictionary definitions for many of the unscrambled words. Two word unscramble results are provided in two formats for easy comprehension by the user. There is no limit to the number of word combinations provided whether for one or two word unscramble solution sets.
The site is mobile friendly and fully https/tls security compliant. Fast and easy, unscramble.net provides the most accurate and complete word, letter and anagram solutions available. Trust the oldest and most reliable unscramble tool on the net. Word lists are constantly being updated from reliable sources. Android and iOS apps are coming soon.


text:
- Health
Patient Care
I Want To...
I Want To...
Find Research Faculty
Enter the last name, specialty or keyword for your search below.
School of Medicine
I Want to...
Apply for Admission
Share this page: More
Abimbola Aina, M.D.
Assistant Professor of Gynecology and Obstetrics
Female | Languages: English, Yoruba
Appointment Phone
Main Location
The Center for Maternal and Fetal Medicine
Out-of-State & International Patients +
Out of State Patients
Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)
International Patients
Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)
- Assistant Professor of Gynecology and Obstetrics
The Center for Maternal and Fetal Medicine
Appointment Phone: 410-740-7903
11065 Little Patuxent Parkway
Suite 100
Columbia, MD 21044 map
Maternal Fetal Medicine, Multiple Gestations, Obstetrics
Research Interests
Preterm labor; Thrombophilia in pregnancy; Cervical incompetence
Dr. Abimbola Aina-Mumuney is an assistant professor in the Johns Hopkins Medicine Department of Gynecology and Obstetrics. Her areas of clinical expertise include high-risk pregnancy conditions and prevention of preterm labor.
Dr. Aina-Mumuney received her undergraduate and master's degrees in chemistry from Harvard and Radcliffe colleges. She earned her M.D. from Harvard Medical School and completed her residency in obstetrics and gynecology at Henry Ford Hospital. Dr. Aina-Mumuney came to Johns Hopkins to perform a fellowship in maternal-fetal medicine before joining the faculty in 2004.
Dr. Aina-Mumuney's research interests include thrombophilia in pregnancy, preterm labor and cervical incompetence. In 2009, she teamed up with Johns Hopkins biomedical engineering graduate students to develop a new uterine monitoring system. The students have established a start-up company, CervoCheck for which Dr. Aina-Mumuney now serves as clinical consultant. With her assistance, they have been awarded numerous grants and awards from the Maryland Technology Development Corporation, the Technology Accelerator Fund and the LifeBridge Health Entrepreneur Challenge. Most recently, she was awarded a grant from the National Institutes of Child Health and Human Development as principal investigator. Their device has been patented and is currently being tested in an ovine model.
Dr. Aina is a fellow of the American College of Obstetricians and Gynecologists and a member of The Society for Maternal-Fetal Medicine. She has served as a reviewer for several medical journals, including the American Journal of Obstetrics and Gynecology, Clinical and Experimental Hypertension and Gynecologic and Obstetric Investigation. Dr. Aina has published numerous peer-reviewed research articles on preterm labor and perinatal disease. Dr. Aina-Mumuney also has an interest in education and often participates in the mentoring of residents and fellows.
Featured Video
Pregnancy Beyond Age 35
Additional Information
Education +
- Harvard Medical School / MD (1997)
- Henry Ford Hospital / Obstetrics and Gynecology (2001)
- American Board of Obstetrics and Gynecology / Maternal and Fetal Medicine (2008)
- American Board of Obstetrics and Gynecology / Obstetrics And Gynecology (2005)
Research & Publications +
Selected Publications View all on PubMed
Aina-Mumuney A,Hwang K, Sunwoo S, Burd I, Blakemore K. The impact of maternal body mass index and gestational age on the ability of the tocodynamometer to detect uterine contractions: a retrospective study in a US population. J Perinatol. Submitted.
Singer N, Aina-Mumuney A, Poling J, Burton EC. Fetal Death Resulting From An Isolated Congenital Partial Pericardial Defect.Obstet Gynecol. 2014 Feb; 123(2 Pt 2 Suppl 2):443-6.
Stewart A, Aina-Mumuney A, Blakemore K, Fischer A. The degree of fetal bowel dilation as a predictor of postnatal surgery: risk stratification by the degree of dilation. Obstet.Gynecol., 2012; 206: Supplement, S157-S158.
Alper AB, Yi Y, Rahman M, Webber LS, Magee L, von Dadelszen P, Pridjian G, Aina-Mumuney A, Saade G, Morgan J, Nuwayhid B, Belfort M, Puschett J. Performance of Estimated Glomerular Filtration Rate Prediction Equations, Preeclamptic Patients. Amer J Perinatol 2011; 28: 425-30
Aina-Mumuney A, Wood ED, Corson CL, Stetten G, Jari S, Boehm CD, Blakemore KJ. Clinical consequences of an increasing trend of preferential use of cultured villi for molecular diagnosis by CVS. Prenat Diagn. 2008 Apr;28(4):332-4.
Aina-Mumuney AJ, Holcroft CJ, Blakemore KJ, Bienstock JL, Hueppchen NA, Milio LA, Crino JP. Intrahepatic vein for fetal blood sampling: one center's experience. Am J Obstet Gynecol. 2008 Apr;198(4):387.
Aina-Mumuney AJ, Fischer A, Blakemore K. Recommendations for Antenatal Surveillance in fetal gastroschisis: Letter-to-the-Editor, J Reprod Med 2007. 52(6); 577-8.
Aina-Mumuney AJ, Blakemore KJ, Fischer AC. Reply to Letter-to-the-Editor. Am J Obstet Gynecol 2005 Mar;192(3):986-7
Book Chapters, Monographs
- Simpkins F, Aina-Mumuney AJ. Third-Trimester Bleeding in: The Johns Hopkins Review of Gynecology and Obstetrics. pp 47 (4). Publisher: Lippincott Williams & Wilkins, 2004.
- Szymanski LM, Aina-Mumuney AJ. Hematologic Disorders of Pregnancy, in The Johns Hopkins Manual of Gynecology and Obstetrics, 4th edition, ed Fortner KB, Szymanski LM, Fox HE, Wallach EE, Lippincott Williams and Wilkins, Philadelphia, PA 2007; pp 215-30.
- DeStephano C, Aina-Mumuney AJ. Gastrointestinal Disease in Pregnancy, in The Johns Hopkins Manual of Gynecology and Obstetrics, 5th edition, ed Fortner KB, Szymanski LM, Fox HE, Wallach EE, Lippincott Williams and Wilkins, Philadelphia, PA 2013, In Press.
Academic Affiliations & Courses +
Activities & Honors +
- Award of Research Excellence, The Society for Maternal Fetal Medicine Annual Meeting, 2014
- Fellows in Academic Career Program, NIH/NMA, 2002
- Hippocrates Award, 1999
- John Harvard Scholarship for Academic Achievement, Harvard College, 1993
- Elizabeth Cary Agassiz Merit Award for Outstanding Academic Achievement, Radcliffe College, 1993
- National Science Foundation Award, synthesized antibiotics produced by nematode worms, 1990
Videos & Media +
Obesity and Pregnancy
Pregnancy and Diabetes
Gestational Diabetes


text:
You know when you're walking down the street, minding your own business, and then suddenly you buy an [eponymous broadband handheld that is not so much a berry as a drupelet]? Well, it happened to me. My old flip-phone was perfectly fine, except it was so old that people used to gape in amusement and say "Awwwww" whenever I used it. Plus, it needed recharging every 45 minutes. So the other day I was walking past a wireless storefront (and thinking what a blight they are on our community) when it sucked me in and made me buy this thing that lets you check e-mails and web-surf and alter airline flight patterns from the palm of your hand. I can also blog with it, which means I can social-network from the bathroom in far greater detail.
Take a moment to calm yourself.
Summer mode officially takes hold today, when Robert finishes his last day of kindergarten. I've looked upon this day with mixed emotions, because as proud as I am of him, and happy that he can begin his life of leisure, summer also meant moving out. The plan throughout was to move as early in the summer as possible, in hopes that seeing me come back to the apartment and care for them every weekday would help build their faith that I'll still be a big part of their lives. Plus, now that the wounds of this experience were scabbing over, sooner or later I'd have to rip off the Band-Aid.
That left only the simple job of navigating the New York real estate market, and the opportunistic scumbags therein, to find a place. I'm a big believer in real estate karma, and since it took me one day to find the apartment I'm in now I was convinced I was due for a long, hard slog through shabby closets, stifling cologne, and a four-figure broker fee steep enough to cause sharp pains in the bowels for weeks to come.
Then, out of the beautiful blue, a friend phoned to say his neighbors had just moved out. A 600-foot one-bedroom (truly! not just a studio with sheet stapled to the ceiling!), EIK, courtyard views, in the quiet back of the building. And since it wasn't listed yet, there would be no fee.
TwoBert and I were there in 20 minutes. I met the super. I met the neighbors. I ate lunch in the new coffee bar the next block over. I applied that afternoon, and the next morning, bam. I was approved. My lease starts Tuesday.
I had been wincing at that Band-Aid for months. And now, with the aid of some mystical serendipity, it's off.


text:
Zucker's OT Goal Gives Wild 3-2 Win Over Blackhawks
ST. PAUL, Minn. -- Beating the Chicago Blackhawks usually requires a certain kind of performance: bruising, aggressive and unflappable.
That's precisely what the Minnesota Wild produced, entertaining the fans at their first home playoff game in five years.
They had a little luck, too, when Jason Zucker blindly sent his bad-angle overtime shot toward the goal.
Zucker scored at 2:15 of the extra period to give the Wild a 3-2 victory on Sunday to pull within 2-1 in the Western Conference quarterfinal series.
"I don't know if I even saw the net. I probably didn't even look at the net," said the rookie Zucker, who raced to the corner and jumped against the glass to celebrate. "I just tried shooting it, and it happened to go in for me."
Pierre-Marc Bouchard had a goal for the Wild after Johnny Oduya scored for the Blackhawks late in the first period. Patrick Kane had two assists for the Blackhawks and has five in the series.
Zach Parise's first goal of the series came early in the third period, but Duncan Keith got one back for the Blackhawks with 2:46 left in regulation after a slow line change by the suddenly conservative Wild.
That forced the second overtime in three games of this best-of-seven series. But rather than losing their edge in the locker room, the Wild returned to the ice after the third intermission with the same fire they had all afternoon.
"They just took it to another level," Blackhawks captain Jonathan Toews said.
He added: "You can't go out there and try to make pretty plays. It's got to be ugly. We're not doing that enough. Once we start doing that, we've got the strength, the speed and skill to get on the board and make things happen."
Game 4 is here on Tuesday night.
"I think we have to get greasy goals if we want to be successful. There's too much on the outside. We've got to get determined in that front area," Blackhawks coach Joel Quenneville said.
After taking the top-seeded Blackhawks to overtime in Game 1 at Chicago, the Wild fell flat and lost 5-2 in Game 2. They took full advantage of the shift in venue and fed off the noise and excitement in the building.
Trying to match the Blackhawks and their speed, deft passing and seemingly infinite depth would be an impossible task for the Wild, so they knew they needed to bring more energy to fuel the announced crowd of 19,238 and a nasty streak to distract the visitors a bit from their finesse-based game.
The hits in the first period were 17-4 in favor of the Wild and 34-13 for the game, with eight by Cal Clutterbuck and seven by Devin Setoguchi.
"They've got some physical players, and I think the crowd was really into the game too," Keith said. "Loud building. They got that rave music going all game long. It gets the place rocking in there."
Corey Crawford made 34 saves for the Blackhawks, but the Wild found a potential weakness on the top shelf. All three of their goals went high. The last two of them came off a feisty forecheck.
Rookie Charlie Coyle fished the puck off the end boards to set up Parise, the first goal of the series for the first line. Then Matt Cullen didn't give up on maintaining possession after falling on his stomach behind the net in overtime, poking a pass to Zucker before Oduya swooped in.
"I'm a Minnesotan, so I know how long people have been waiting for playoff hockey. It's a lot of fun," Cullen said.
Bouchard and Stephane Veilleux are the only two players left from the 2003 Wild team that reached the Western Conference finals, and Veilleux played for two other teams before returning last season. They're two of five players, with Mikko Koivu, Josh Harding and Niklas Backstrom, remaining from 2008, the last time they made the playoffs.
"You've got to go through it, and you've got to experience it," Parise said. "Remember that some of these guys have only been in three playoff games. But the good sign is that we got better from the first two games."
The Blackhawks started slowly in the playoffs in 2010, too, when they won the Stanley Cup. With 10 players still around from that season's roster, including most of their star-packed core, they're poised to make another run for the title.
Three years ago, they fell behind Nashville 2-1 in the first round before winning the series in six games. They needed six games to beat Vancouver next, too, before sweeping San Jose to reach the finals.
"We had the momentum going into overtime, but we're just going to have to forget about that one," Crawford said.
The Wild outshot the Blackhawks 29-17 over the first 40 minutes. Harding stopped 25 shots in all.
"It was a close game, but I think at the end of the day, they deserved to win tonight," Keith said.
Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
Looking for design inspiration? Browse our curated collections!
The watermark in the lower right corner of the image will not appear on the final print.
Chicago White Sox by Steven Parker - 8" x 10"
Luster Photo Paper
Rolled in a Tube
Assembly Charge
Chicago White Sox poster by Steven Parker. Our posters are produced on acid-free papers using archival inks to guarantee that they last a lifetime without fading or loss of color. All posters include a 1" white border around the image to allow for future framing and matting, if desired.
Ships Within
2 - 3 business days
There are no comments for Chicago White Sox. Click here to post the first comment.
All prints ship in durable cardboard tubes.
Fine Art America is one of the largest, most-respected giclee printing companies in the world with over 40 years of experience producing museum-quality posters and prints. All of our posters are produced on state-of-the-art, professional-grade Epson printers.
We use acid-free paper with archival inks to guarantee that your posters last a lifetime without fading or loss of color. All posters include a 1" white border around the image to allow for future framing and matting, if desired.
Posters ship within 3 - 4 business days in durable cardboard tubes.
Average Rating (4.93 Stars):
BoBrooks Brooks
June 23rd, 2019
The teams logo for the Chicago White Sox on a decorative metal plate background.
Hello to one and all, I would like to welcome you back if you have visited my site previously. If this is the first time you are visiting my site, I welcome you and hope you enjoy the many pictures I have posted. I first started using my artistic talents by painting with oils and acrylics. With practice and time, I eventually sold some of my paintings to the public as well as my friends. Due to the lack of time and other commitments, I was unable to pursue painting for quite awhile. I am now at a point in my life where I can again paint and photograph wildlife and other pictures of nature. While traveling around the U.S. and cruising, I have been able to capture many beautiful scenes of nature which includes, animals,...
Our return policy is very simple:
If you're not happy with a purchase that you made on FineArtAmerica.com, for any reason, you can return it to us within 30 days of the order date. As soon as it arrives, we'll issue a full refund for the entire purchase price. Please note - Fine Art America does not reimburse the outgoing or return shipping charges unless the return is due to a defect in quality.
Fine Art America sells thousands of pieces of artwork each month - all with a 100% money-back guarantee. We take great pride in the fact that hundreds of thousands of artists have chosen Fine Art America to fulfill their orders, and we look forward to helping you select your next piece!
All posters ship from our production facility within 2 - 3 business days of your order.


text:
As some of you might know, I'm an experimental psychologist. I'm currently running an online experiment for which I need writers. It takes just over half an hour — I'm afraid I can't pay you, but you might find the experiment fun, and you'll be doing your bit for science!
If you're interested, do read on:
The experiment will ask you to continue writing a scene after a brief genre-based prompt to get you going. You'll do this three times. There's also a brief pre-experiment questionnaire and post-experiment questionnaire. Your participation is entirely voluntary and you can stop at any time.
There's more detailed information on the experiment page itself, which you can get to via this link:


text:
|Home > Florida Then & Now > A Short History of Florida > Vocabulary Mapping
Vocabulary Mapping
This strategy will aid students in expanding their vocabulary development using a simple mapping format.
The students place the vocabulary word in the middle of a blank piece of paper.
The students label each of the four corners of the paper with the following headings: definition, synonym, sentence, and picture.
- The students draw arrows radiating from the vocabulary word to each of the four headings.
The students complete what is being asked for under each of the four headings in regards to the vocabulary word.
The students share and discuss their vocabulary map with the class.
|Home > Florida Then & Now > A Short History of Florida > Vocabulary Mapping
Florida: A Social Studies Resource for Students and Teachers
Produced by the Florida Center for Instructional Technology,
College of Education, University of South Florida © 2002.


text:
signature]. From Father Thames. Drawing. [Click on image to enlarge it.] Text and formatting by George P. Landow. [You may use this image without prior permission for any scholarly or educational purpose as long as you (1) credit the University of Toronto and the Internet Archive and (2) link your document to this URL in a web document or cite it in a print one.]. G. Ayton Symington [Image of the artist's
Related Material
- The Church and Village of Cotes by Symington
- Steam-powered canal barge
- Canal boats along the Avon
- Regent's Canal and canal boats. London.
Higgins, Walter. Father Thames. London: Wells Gardner, Darton & Co. n.d. Internet Archive Web. 15 April 2012.
Last modified 16 April 2012


text:
Filter by content types:News stories Blog posts Feature articles Polls Image galleries
Filter by tags:
|Cases Chipsets Cooling Copyright CPUs Displays Folding Game consoles
|GamingGraphics Input devices Internet Linux-Unix Mac Memory Miscellaneous
|Mobile computing Motherboards Multimedia Networking Operating systems Personal tech Podcast Power
|Servers Shortbread Software Storage Systems The Tech Report Windows Workstations
Poll: What product category are you most excited about for 2018?
The almost-past year of 2017 was a big one for CPU technology announcements. We got AMD's Ryzen and Threadripper units plus Intel's...
Poll Question: • What product category are you most excited about for 2018?
Type: News story Tags: CPUs Graphics Miscellaneous
Poll: How has the Ethereum craze affected your graphics card plans?
The many Radeons and GeForces in the TR labs aren't being harnessed for the Ethereum cryptocurrency craze, but many other prospective tycoons have been buying...
Poll Question: • How has the Ethereum craze affected your graphics card plans?
Type: News story Tags: Graphics
Poll: How do you enjoy streaming?
The public broadcasting of gaming through Twitch, YouTube, and other streaming services has captured the attention of hundreds of millions of viewers across the globe....
Poll Question: • How do you enjoy streaming?
Type: News story Tags: Gaming
Poll: Are you planning to upgrade to a GTX 1060 or RX 480?
Nvidia's GeForce GTX 1060 is available now, and it's joining a heated battle with AMD's Radeon RX 480 in the $200-$250 price range....
Poll Question: • Are you planning to upgrade to a GTX 1060 or RX 480?
Type: News story Tags: Graphics
Poll: Will you be upgrading to Nvidia's GeForce GTX 1080?
The first round of reviews are in, and it looks like the GeForce GTX 1080 really has taken the single-GPU graphics performance crown—at least...
Poll Question: • Will you be upgrading to Nvidia's GeForce GTX 1080?
Type: News story Tags: Graphics
What do you trust more: mechanical or solid-state storage?
SSDs are slowly taking over the PC storage industry. They've become the default in slim mobile systems and are increasingly working their way into desktops....
Poll Question: • What do you trust more?
Type: News story Tags: Storage
What's your biggest PC bottleneck?
Modern PCs are incredibly powerful. They have multi-core CPUs, massively parallel graphics processors, gobs of memory, and...
Poll Question: • What's your biggest PC bottleneck?
Type: News story Tags: CPUs Graphics Storage Memory
Poll: What's your favorite system for gaming in the living room?
Desktop PCs are great for gaming. However, some of us would rather play in the living room, where we can sink into a couch,...
Poll Question: • Favorite gaming system for the living room?
Type: News story Tags: Gaming
Poll: To which release are you most looking forward?
Between all our reviews and news, not to mention reader meetups, we've kinda been neglecting our front-page poll. Today, we're freshening things up...
Poll Question: • To which release are you most looking forward?
Type: News story Tags: Graphics Mobile computing Game consoles Operating systems
Which game is the new champ of PC visuals?
If you've seen the latest round of games, you'll know what I mean when I say that we've clearly entered a new era in PC...
Poll Question: • What's the best-looking PC game?
Type: News story Tags: Graphics Gaming
Poll: What will be the fate of Windows RT?
Windows RT is a curious beast. It features the tablet-friendly Modern UI Style and is compatible with the ARM-based processors found in most modern...
Poll Question: • What will happen to WinRT?
Type: News story Tags: Mobile computing Operating systems
Poll: What will happen first?
It's time to peer into our crystal balls and predict the future. There are a number of things in the tech industry that should—or at...
Poll Question: • What will happen first?
Type: News story Tags: CPUs Graphics Storage Operating systems
Poll: Where do you most want a high-DPI display?
High-DPI screens are all the rage these days. Apple deserves credit for starting the trend with the Retina display on the iPhone 4, and...
Poll Question: • I most want a high-DPI display on my:
Type: News story Tags: Graphics Displays
Poll: How will Kepler fare against the Radeon HD 7970?
If you've been paying attention to the GPU scene, you'll know that AMD's next-generation graphics architecture has already arrived in the Radeon HD 7970....
Poll Question: • Kepler's gaming performance will be:
Type: News story Tags: Graphics Gaming
Poll: What's the best PC game of 2011?
This holiday season has been a busy one on the PC gaming front. Looking back, so has the year as a whole. We've...
Poll Question: • Best PC game of 2011?
Type: News story Tags: Gaming
Poll: To which new chip are you most looking forward?
One of the best—and worst—things about the PC industry is the steady trickle of new technology. There's always something better coming just around the corner,...
Poll Question: • I'm most looking forward to:
Type: News story Tags: CPUs Graphics
Poll: Battlefield 3 or Modern Warfare 3?
Modern Warfare 3 looks like it's going to set all kinds of records for the biggest entertainment launch in history. It's not the only...
Poll Question: • I'd rather play:
Type: News story Tags: Gaming
Poll: How should PC games deliver higher-quality art assets?
A disturbing trend seems to be taking hold in the gaming industry: delays to the PC versions of cross-platform releases that otherwise come out on...
Poll Question: • Would you rather PC games be:
Type: News story Tags: Gaming
|Official Overclocking: Intel's Performance Maximizer reviewed
|Raspberry Pi 4 sports a faster SoC and dual displays for $35
|Bargain basement: 32 GB of 3000 MT/s memory for $117, and a lot more
|Fish Tales: I watercooled my Vive
|You're not charging it wrong: Apple recalls some MacBook Pros for battery safety
|Intel graphics driver 26.20 says "game on" for Steel Division 2, F1 2019, and more
|FSP Dagger Pros pack 650W into petite SFX PSUs
|National Ice Cream Soda Day Shortbread
|Bargain basement: a 32", 144-Hz LG 32GK650F-B monitor for $310, and much more
|Thanks for writing this Ben. Nice walkthrough of the featureset both theoretical and practical. Purportedly, that's what us Gerbils like.


text:
JLP wrote:Your comment in reply to my post was " I knew you would not be far away". Some people might find that intimidating. Putting a label on people as lefties because they appear to be more tolerant about certain things than you can be seen as intimidating too as can telling people to ignore your threads because they have a different view point to you.
'I knew you would not be far away' is intimidating? Fuck me, I have really heard it all now.
The reason I am opposed to such lefties is because they are far LESS tolerant about things in life than I am - I do not believe in any prejudice or intolerance: they clearly do. And they are hypocrites.
I told a poster to ignore my thread because they stated I was making a drama, when I was just giving my opinion. I ignore threads all the time on here that I disagree with. No biggie.
Truthfully, hand on heart, I am one of the most peaceful, non-violent and non-aggressive people that I know. I have never, ever tried to intimidate anybody at any point in my life because it is just not in me. I cannot help it if you take the things I state in that way - I only state my opinion and will fight my corner if I believe in something, but I never do so with any hint of intimidation.


text:
A long-time collecting friend and labelologist, Bob Kay has taught me ways to trace brewing history from a simple piece of paper. Most beer bottles contain a neck as well as a body label; some more elaborate packages contain back and shoulder labels or even a foil neck wrap. They are all sources of information, and in the world of beer collectibles, we can learn more from the label than from any other source. This small artifact plays an important role in deciphering a brands history.
A few clues make it easy to identify labels with a particular period of time. For example, pre-Prohibition labels contained the statement, Guaranteed Under Food and Drug Act June 30, 1906. When bottling began, the brewery's name and city were actually embossed onto the bottle. Early paper labels were initially applied over the embossing until the supply of these bottles was depleted.
The most sought-after early labels among collectors are the die cuts. These are labels cut in a way to highlight certain features in the shape of the brands logo, a method used by breweries to add some uniqueness or embellishment to a particular beer. Die cuts were more prevalent before Prohibition when labels were applied by hand; modern labeling machines run at a much faster pace when applying a square or oval shape.
Since very few brewers operated their own bottling works, many pre-Prohibition labels listed a separate bottling company as well as the brewery name: for example, Christian Moerlein Brewing Company, Cincinnati, Ohio, Bottled at the Pittsburgh Branch. The beer was produced in Cincinnati, then sent up river in kegs to Pittsburgh to be packaged in bottles.
Many pre-Prohibition labels resemble the artwork of currency and postage stamps of the time. They contain simple graphics and few colors, which kept the printing cost down. Given the high illiteracy rate among the beer-drinking public, there was very little text.
In fact, some brewers took advantage of the under-educated public by copying the names and graphics of the larger brewers. Beers brewed in New York or Minnesota may have the word Milwaukee, Cincinnati or St. Louis prominently displayed as part of the label design. This was a marketing ploy to fool the under-educated into believing they were drinking a more cosmopolitan brew, as well as an attempt to give the literate consumer confidence in the product.
These borrowed titles also served to define the beers style. This was a practice already prevalent in Europe, where many brewers produced mnchener (Munich), wiener (Vienna) or bohemian (Pilsen) type beers to define style and capitalize on previous successes.
To slow the prohibition movement, some turn-of-the-century labels promoted beer as a food or health product. Continuing the trend, some brewers in the early years of Prohibition were able to brew beer for medicinal purposes. A prescription was needed to secure your allowance of the golden nectar. Some brewers also produced a hopped malt extract and sold yeast separately.
During Prohibition itself, words like cereal beverage, non-intoxicating, malt beverage and tonic appeared on most of the labels. The wording manufactured by instead of brewed by also was used. Breweries used names like products company or beverage company, or omitted the words brewery, ale or beer from the company's name altogether.
During World War I, the German heritage of breweries was played down or done away with completely. Various printers and brewers union labels and symbols often appear as part of labels dating from this era.
Dave Gausepohl
Beer Dave Gausepohl has collected breweriana since 1974 and has a personal collection of over 400,000 items. He has visited over 1,000 breweries and tasted well over 10,000 different brews from the world over.
Hi Dave. I am not a collector but recently purchased a beautiful beer glass that is embossed? and from the Frederick Fisch Brewery in Rogers City. If the research I found online is correct, the brewery opened in 1909 and closed in 1914. I got the beautiful glass at an estate sale in Rogers City! I'm looking for someone who will give the glass a good home and give me a fair price. Are you interested in seeing it? Thank you. Phil Heimerl


text:
Related Categories: Australian Banks, AMP Bank Ltd, ANZ Banking Group Limited, Auswide Bank Ltd, Bank of Queensland Limited, Bendigo & Adelaide Bank, Commonwealth Bank, Community CPS Australia Limited, Defence Bank, Heritage Bank Limited, Hume Bank Limited, Macquarie Bank Limited, Mecu Limited, Members Equity Bank Limited, MyState Bank Limited, National Australia Bank Limited, Police Financial Services Limited, Police & Nurses Limited, QT Mutual Bank Limited, Rural Bank Limited, SGE Mutual Limited, Victoria Teachers Limited, Westpac Banking Corporation
Formerly known as the Police Credit Union, Police Bank Ltd offers a wide range of popular financial products at very competitive rates. Products include Savings Accounts, Insurance, Loans, Term Deposits, Credit Cards, Salary packaging and Financial Planning Services. One of the most common misconceptions about these types of institutions is that you have to be in the Police force to take advantage of these services. This is not the case, anyone wishing to apply to be a member of the Police bank may do so through this Applications and Forms section of the website. Check out the range of competitive and convenient finance related products offered by Police Bank Ltd.
No Results
B6, 66 Kennedy Drive
Cambridge, Tasmania 7170
Clever Fitness offers fitness equipment finance Australia
121 Cardigan Street
Carlton, Victoria 3053
Loans are the major offerings made by BankVic that includes
130 Stirling Street
Level 7
Perth, Western Australia 6000
P&N Bank provides financial products and services, including
454 St Paul's Terrace
Fortitude Valley, Queensland 4006
QT Mutual Bank home loans, car loans, personal loans,
77 Grenfell Street
Shop 2
Adelaide, South Australia 5000
The wide variety of financial products and services offered
363 George St
Suite 2503
Sydney, New South Wales 2000
Woori Bank is a Korean Bank, which has made its mark on the
(2833 Finance Enquiries since 06-04-2016 09:24AM)
59 Buckingham Street
Surry Hills, New South Wales 2010
Select Encompass Credit Union is a community based banking
(1263 Finance Enquiries since 27-10-2016 10:38PM)
222 High Street
Kew, Victoria 3101
BankMecu banking products include home loans, car loans,
(3980 Finance Enquiries since 04-05-2015 01:08PM)
2 Park Street
Citigroup Centre
Sydney, New South Wales 2000
Global Consumer Group – This group consist of Citibank and
(4482 Finance Enquiries since 13-06-2015 10:44AM)
39-41 York Street
Sydney, New South Wales 2000
Bank of China (Australia) Limited offers a number of deposit
(932 Finance Enquiries since 12-06-2015 12:30PM)
Preparing for retirement is a challenging thing for most people. It's so easy to get caught up in the present that you forget about your financial well-being in the future. The unfortunate thing is that most people do not spend enough time planning for retirement.
The forex market is the most active and liquid exchange platform in the world. Similar to the ASX, the forex market allows investors to trade security instruments; specifically, forex traders deal in fiat currency. this paper discusses profiting from currency exchange fluctuations in the Forex
Looking to cut inefficiencies in your business? Of course you are, or at least you should be. Cloud computing allows you to run your small business more efficiently while saving you time and money, read on to see how Cloud Computing can help your business boost it's output.


text:
Newest Agricultural Labratory in Brookings Celebrates Anniversary
BROOKINGS, S.D. (AP) - South Dakota's newest agricultural testing laboratory is celebrating its one-year anniversary.
South Dakota Agricultural Laboratories LLC scheduled an open house on Friday in Brookings. Owner Regina Wixon says the lab employs more than 10 people, many of them key employees from a lab on the South Dakota State University campus that closed in April 2011 due to budget cuts.
The new lab opened in October 2011. Wixon says it does analysis on everything from pesticides to meat to manure.
Copyright 2012 by The Associated Press. All rights reserved. Material may not be redistributed.


text: Its worth reconsidering C#, both .NET and Mono. Its more than Java with a few tweaks. I find it a much more pleasant experience than Java. In particular, its worth familiarising yourself with the LINQ part of the language, which is something extremely powerful and unique to C#. Its also worth considering Visual Studio as a huge bonus, possibly the best IDE on the market. For me the languages of choice are: Python, C#, and C/C++, in order of speed. On Mon, Jan 17, 2011 at 11:20 PM, Stephen Williams <sdw at lig.net> wrote: > Additions and comments on these points would be helpful. In the following, > proprietary-ish choices are filtered out (Visual Basic, .Net, etc.) except > when they have a very privileged spot in a hot market (Objective-C/Cocoa) > and are at least mostly open. (And, no, Mono isn't going to make .Net > attractive. It is just Java with a few tweaks and a different library. Not > worth the headaches.) > > I'm working on building and documenting some architecture and coding > techniques and examples. Due to recent activity, and also breadth of market > footprint for at least certain kinds of apps, my main targets are > Java/Android and Qt/C++, with Objective-C/Cocoa when I get time. These > days, frameworks / libraries are so important and torque the design so much > that I think of language/framework combinations as independent language > points. For instance, C++/Qt is distinct from C++/STL/Boost which is miles > away from C++/MS-whatever, even though generic C++ code would work with any > of them. > > For desktop app development, the obvious choices are: C++/Qt (possibly with > OpenFrameworks or OpenGL additions), Java (Swing or SWT or Processing), or > Flash/Air/Flex. There doesn't seem to be a strong reason do go with > Objective-C/Cocoa for desktop applications, unless you only want to target > Mac OS and iOS/iPhone/iPod/iPad. PyQt is interesting as it leverages > cross-platform Qt and Python in a powerful way. Mostly secondary to C++/Qt > so far though. > > For mobile development, current front-runners in terms of market and/or > technology: Android, iOS/Objective-C, and Qt (either directly for Nokia > smartphones or as an emerging method for Android). > > For web development, Javascript via various libraries (Node.js, etc.) and > with Java via GWT doing HTML5 seem tops currently, plus Flash as a separate > strong option and Java applets as a weaker, but sometimes important option. > For instance, I'm finishing a Java-based PC emulator that runs as an > applet, similar to but better than JPC (JavaPC) which is uber cool. > > For server development, the top candidates are Java, Python, Ruby, and PHP. > With current licensing, I wouldn't be surprised to see the rise of C++/Qt > as a server development environment. A lot of server environments (Apache, > etc.) are written in C or C++, but few applications. Qt provides a nice > enough application environment (like effortless reference counted auto > shallow/deep copy objects and templates along with one of the best > thread-safe signaling mechanisms) that it would be a good alternate choice > to Java and Python. Javascript has been getting some server play too. And > Perl is still there, but not growing or interesting anymore. I'm not too > hot on Ruby: While there is great buzz, momentum, and fast-start frameworks, > there seems to be a fatal shallowness that is a turnoff. > > I mostly count the j* (jython, jruby, scala, etc.) languages as part of > Java, although few of them would work with Android/Dalvik. > > There are some interesting emerging languages: Go, etc. What are the best > possibilities here? > > In order of interestingness for client/desktop: > Java - Client: Android & Processing/SWT, Web: GWT, raw to JS libraries > C++ - Client: C++/Qt, Web: C++/Wt (GPL/commercial) or similar for web > Objective-C: Client: Objective-C/Cocoa > Python - Client: PyQt, Web: various frameworks [1], web2py for instance > PHP - Web: Various frameworks [2], Symfony for instance > > For web development, the order is: > Java/GWT, possibly with a C++ layer > Python/web2py et al, possibly with a C++ layer > C++/Wt, possibly with a Java layer > PHP, Symfony et al > > PHP, while popular, venerable, and having grown past the simple start, is > still hard to take as seriously as Java/C++/Python/Objective-C for > potentially large, complex, and/or scalable projects. > > Now that it is easy to do rich Java-C++ integration (I'm publishing / > presenting soon!), the line is a little more blurred between Java/C++ both > for Android and other client environments and for server apps, GWT for > instance. However, Qt is a far better GUI framework than anything available > for Java. > > [1] http://wiki.python.org/moin/WebFrameworks > [2] > https://secure.wikimedia.org/wikipedia/en/wiki/Comparison_of_web_application_frameworks > > sdw > -- > Stephen D. Williams sdw at lig.net stephendwilliams at gmail.com LinkedIn: > http://sdw.st/in V:650-450-UNIX (8649) V:866.SDW.UNIX V:703.371.9362 > F:703.995.0407 AIM:sdw Skype:StephenDWilliams Yahoo:sdwlignet Resume: > http://sdw.st/gres Personal: http://sdw.st facebook.com/sdwlig > twitter.com/scienteer > > _______________________________________________ > FoRK mailing list > http://xent.com/mailman/listinfo/fork >


text:
It's been said by quite a few internet pundits that the Paladin is the easiest of the WoW classes to play. While I don't know whether that's the case --I could make a good argument for Arcane Mages taking that slot-- Ret Paladins are certainly one of the least "button heavy" classes to play.
One of the big knocks about Ret Paladins in Wrath was the lack of any real rotation. The "rotation" a Ret Pally had was the equivalent of a giant game of Whack-a-Mole: whatever ability was off CD was the button you used. Sure, there were a few choices here and there, but in this case perception was indeed reality. Cata actually introduced a rotation (of sorts) to Ret, which boiled down to
Crusader Strike -> filler -> Crusader Strike -> filler -> Crusader Strike -> Templars Verdict
with a few items such as Inquisition, Zealotry, and Avenging Wrath inserted as needed.
This is not very button heavy. (Stop laughing, Arcane!)
With Ret, once I took care of some basic keybindings and a few macros, there wasn't much to do. Since I don't raid, I'm not too concerned about squeezing every last bit of DPS that I can out of my rotation. I know the spec, so as long as I can work it well enough I'm fine. Even a Frost Mage isn't that button heavy, particularly once the keybindings and macros are settled into place. In PvP, it's all about CC and driving the other side batty.**
But when I started leveling that Warlock, my laissez-faire attitude hit a brick wall.
With Adelwulf, there were not only a lot of buttons, but you get them all launched at you in quick leveling succession.
By L20, I knew my old button system was in trouble.
By L30, it was just about untenable. My fingers ached, and I knew that if I didn't overhaul my keys I'd get a serious case of carpal tunnel syndrome, not to mention being completely incompetent.
Of course, that meant that my old keybinding setup had to be thrown out the window, which is why I balked at the task for so long. Muscle memory was going to be a bitch and a half while I settled into something reasonable.
My first attempts went poorly. Oh, I knew what I wanted from a Warlock angle so that was easy enough, but I didn't expect how much trouble it would be to reorganize my Ret keybindings into something I could use effectively. In my first run after keybindings 2.00, I ran Q through AV. Or rather, Q bubbled his way through AV. I'd placed Divine Shield too close to a button I hit more often, and I was accidentally spamming DS the entire run. Iteration 2.01 didn't go so well either, as every time Art of War procced I hit the wrong key and had to look away from the screen to figure out what I was doing wrong.
Not good.
Iterations 2.02 through 2.17 were incremental improvements until I finally got to the layout I liked. Main attacks on top, debuff removal and cc stuff below that, and rarely used spells on the bottom. There were individual quirks about my setup, like having Exorcism and Hammer of Justice use the same finger as before --but keys on different rows-- kept me from accidentally blowing a CD on something I wanted later. (Trust me, it all makes sense in my mind.)
Turning to Neve, I balked. PvP and PvE spell emphasis on a Frost Mage are different enough that I really didn't want to work on it. Like ever. But when you can't even find your main spells once you login, you have to do something. And I'll be honest: I haven't really finished the job of reorganizing Neve's keys into something that feels natural, even after iteration 2.13.
Even that half baked key setup, however, is much easier on my hands. My fingers don't ache after a couple of games of WSG like they used to. And when I remember where everything is, I can hit the keys more quickly.
If it weren't for trying out that Warlock, I'd probably never have reworked all of this stuff. Amazing how something good can come out of a class that wallows in its use of evil.
I do have one side effect of all this work, however: my left pinkie has a disturbing tendency to accidentally hit the "Sleep" button on my keyboard***. Talk about Imps and their tricks. /grumble
*This is a wordplay on an old series of commercials for the chemical company BASF, whose tagline was "We don't make a lot of the products you buy, we make a lot the products you buy... better." Here's a link to a 14 year old commercial via YouTube: 1997 BASF Ad
**If I've got at least three Alliance trying to DPS down Neve in WSG, I consider that I've done my job. When 1/3 of your team is chasing after one person who isn't a FC, then the rest of your team is freed up to do the dirty work.
***Which, naturally, won't stay disabled.
Tuesday, October 4, 2011
We Don't Make the Class You Play... We Make the Class You Play Better*
Posted by Redbeard
at 4:55 PM
Labels: changes, getting old, UI
2 comments:
- AnonymousOctober 7, 2011 at 9:44:00 AM EDT
Warlocks are great for stretching your keybinding muscles. They have to use a lot of different spells to be effective, and even the simplified PvE environment tends to require an awful lot of keybinding. :)ReplyDelete
I'm glad your lock helped your pally and mage out - see, they're not ALL bad!
@Cyn-- With the way the leveling process has been simplified, I discovered that a lock can easily handle PvE enemies about 2 levels higher in the lowbie zones without quite so much keybinding.ReplyDelete
Well, maybe not ALL bad, but I think that Blizz should have had a "death mechanic" where the summoned demon doesn't vanish, but grabs the lock and then disappears into the earth. More realistic, if you ask me.
Subscribe to: Post Comments (Atom)


text:
The mission of Sigma Xi is to enhance the health of the research enterprise, foster integrity in science and engineering, and promote the public's understanding of science for the purpose of improving the human condition. Membership is available to any student who has, through initial research achievement in a field of pure or applied science, shown an aptitude for research.
For more information, visit Sigma Xi national site or contact faculty advisor Professor William Karstens, firstname.lastname@example.com.


text:
Departure's Gregory Gourdet creates the perfect meals for healthy, outside dining.
November 17th at Revolution Hall, celebrate with one of the nation's most innovative design communities at Portland's premiere annual architecture event! A nationally renowned jury provides a compelling overview of the outstanding design work executed by some of Oregon's most accomplished architects as soul treasure Ural Thomas & the Pain keeps the house energy charged!
We interviewed Laleña Dolby, who is leading Write_On into it's fourth year, and asked her to tell us some more about Write_On - and why letters are more important than ever.
Halloween is here, so we went to Sugar Street Bakery for inspiration on making some spooky treats. "I've got this incredible baking team," says owner Darrell Hames.
Interior designer Max Humphrey has spent the last 10 years designing homes all around the country. Originally based in Los Angeles, Humphrey relocated to Portland this year. With his focus on creating interesting and unpretentious spaces that reflect the people that live and work in them, we asked Humphrey how he helps client with hanging, placing and choosing art in their homes.
Exposed wood, nature inspired prints, low slung furniture lines and a neutral color palette are some of the many elements that make midcentury design so pleasing to the eye. In the spirit of the era from which it came, we poured ourselves a martini and went to work gathering together goods to invoke this iconic style into your own mix.


text:
- Home
- News
- Sports
- Opinion
- Obituaries
- Features
- Special Sections
- Classifieds
- Public Notices
As I read the front page story about the jobless rate on the front page of the July 29 edition of The Lancaster News, it made me think about the recent McClatchy newspaper survey regarding job losses.
It shows that Democrats have had a 62 percent higher job loss than Republicans under Obama. So much for Democrats helping the middle class and minorities.
If you currently subscribe or have subscribed in the past to the The Lancaster News, then simply find your account number on your mailing label and enter it below.
Click the question mark below to see where your account ID appears on your mailing label.
If you are new to the award winning The Lancaster News and wish to get a subscription or simply gain access to our online content then please enter your ZIP code below and continue to setup your account.
|ZIP Code:


text:
U.S. Inflation Is a Window into a Global Growth Risk
Thursday's U.S. consumer price index report showed a meaningful divergence between goods and services inflation.
The U.S. seems to be in a new part of the inflation cycle. U.S. services inflation is stabilizing at a lower level than it was in the 1990s and 2000s. It is long past falling. Goods inflation, on the other hand, is in a new down cycle.
This seems to point to weakness abroad. It all points to a normalizing U.S. domestic economy but more vulnerability abroad.
Here's why: Goods inflation is exposed to global trade. When China was flooding the world with low cost goods in the 1990s and 2000s, it put immense downward on consumer goods prices and held down the overall U.S. inflation rate. Unlike the 1990s and early 2000s, the latest downdraft in goods inflation is likely being driven not so much by an influx of cheap goods produced by low-cost emerging market labor, but by a slowdown overseas driven by over investment in emerging markets during their boom. That's holding down commodities prices.
"An acceleration of global growth is probably a necessary condition for headline inflation to accelerate," economists at Jefferies Group wrote in a commentary on the goods' divergence from services prices.
Services inflation is highly exposed to domestic housing and the cost of domestic labor. When the housing market collapsed and unemployment soared in 2008, it put downward pressure on services inflation. Think of it this way: Most of the cost of a haircut is the cost of the barber at your side and the cost of his rent for that space. Whereas the cost of a car includes the cost of a lot of imported parts, imported commodities and labor from abroad. Services inflation has crept up slowly since 2010, but at 2.4% in January from a year earlier, but it's still about a percentage point below its 3.4% average in the period before the crisis.
Prices are a window into the dynamics of growth. And that global dynamic is clearly now in flux.


text:
Ray Rice may not like talking about it, but his fumbling problems in the playoffs are real.
Rice fumbled in the third quarter of the Super Bowl, and the 49ers recovered, setting up a David Akers field goal that cut Baltimore's lead to 28-23.
Akers, who has been skittish all season, actually missed his first attempt from 39 yards. But a running into the kicker penalty moved him five yards closer, and he made it from 34 yards out on his second try.
The Ravens have the lead, but the 49ers have controlled this game since the lights came back on. We're heading toward what could be a thrilling fourth quarter.


text:
� Flush and non-flush types
� Long and short body
� Rated operational voltage: 10 - 40 VDC
� Output: DC 200 mA, NPN or PNP
� Make and break switching function
� LED-indication
� Protection: reverse polarity, short circuit, transients
� Cable and plug versions
eral purpose inductive prox-
imity switches in industrial
standard nickel-plated brass
housings. M12, M18 and
M30 types. They are able to
handle simple applications
vides adequate sensing per-
formance. Output are open
collector NPN or PNP tran-
sistors. Available with cable
and M12 plug.
Housing style
Housing size
Housing material
Housing length
Detection principle
Sensing distance
Output type
Output configuration
Connection type
Nickel-Plated Brass Housing
Types IA, M12, M18 and M30
short-circuit, transients
sensing distance (S
distance (S
current peaks, separate the prox. switch pow-
er cables from any other power cables, e.g.
motor, contactor or solenoid cables
mechanical stop
cable should be avoided
� 2 nuts NPB
� Packaging: plastic bag


text:
- Spurs vs. Grizzlies: Series Hub
MEMPHIS, Tenn. — The least-talked about story throughout this postseason run by the Memphis Grizzlies has been the late January trade of leading scorer Rudy Gay. In fact, it really hasn't been a topic of discussion at all.
That's probably because the Grizz have done quite well — thank you very much — without him. They posted a team regular-season-best 56 wins and are in the Western Conference finals for the first time in franchise history. And, look, you can't find an analytics guy worth his scientific calculator to suggest the Grizz even remotely miss Gay, a small forward the number-crunchers view disdainfully as a black hole. Gay, with a rap as an inefficient scorer who took shots away from big men Zach Randolph and Marc Gasol, and also apparently stunted the growth of point guard Mike Conley.
But, desperately needing a first win in Game 3 this series against the San Antonio Spurs Saturday night at the FedExForum (9 p.m. ET, ESPN), what would the Grizz give to just have a scoring threat on the perimeter? The Spurs are jamming up the paint because there's no repercussion for leaving Memphis' wings open.
Gay's replacement, Tayshaun Prince, has not been good offensively. OK, so maybe some of that had to do with him chasing Kevin Durant for three quarters every game in the second round. There's no doubt that Prince — with his 6-foot-9 frame and long, gangly arms — is a better defender than Gay, more team-oriented on the offensive end and will move the ball before he puts up a contested shot.
But, at some point, the Grizz have got to get some scoring from their starting small forward — who hasn't scored in double figures since May 3, Game 6 of the Clippers series in the first round.
In the first two games of the West finals he's 3-for-10 from the field for eight points. He's taken two free throws. That has a lot to do with why Prince played just 16 minutes in Game 2, scoring a playoff-low two points, while reserve Quincy Pondexter logged 37 minutes — and scored just seven points with nine rebounds.
Since then, a hot topic has been the possibility for coach Lionel Hollins to alter his starting five. However, on Friday, Hollins said he has no plans to make such a move.
"Whatever it takes to win," Prince said. "I've always been that way and nothing changes for me. Whatever happens, happens. I've never been in a position where I'm worried or concerned about how I'm shooting. I just have to continue to stay confident and when the shots are available take them."
No one will ever confuse Prince for being a volume scorer or shooter such as Gay. Prince's best scoring season was 14.7 ppg back in 2004-05. His career scoring average 12.6 ppg on 45.8 percent shooting. The Grizz would be thrilled with such an uptick.
"He's going to come along. I believe in him," said shooting guard Tony Allen, whose scoring and shooting percentage have tapered off this series to playoff low 8.0 ppg and 35.7 percent from the floor. "I ain't really worried about that too much. I know he can ball, so I believe in him."
Prince's scoring average and shooting percentage has dropped with each series from 8.5 and 40.4 percent against the Clippers; to 6.2 and 29.5 percent against the Thunder; and now 4.0 and 30.0 in the first two games against the Spurs. OK, so maybe some of that has to do with Prince being guarded by Durant last round and now Spurs up-and-comer Kawhi Leonard.
So how can Prince get jump-started? Everyone associated with Memphis is talking about pace. Not running up and down the floor like they're the Nuggets, which they're not, but simply by pushing the ball into the halfcourt quicker and getting into their sets earlier in the shot clock. They believe they're dragging, whether it's taking the ball out of bounds or off defensive rebounds, and allowing the disciplined Spurs' defense to clamp down and force too many bad shots with the clock ticking down.
"No question," Hollins said. "That's what we've been trying to preach this whole series is we need to get up and down the court and not let San Antonio set their defense and call plays with 15 seconds left on the shot clock."
Prince said it should be evident in the first quarter Saturday if the Grizz are indeed successfully quickening the pace.
"It will kind of dictate how we shoot the ball," Prince said. "We have to get into our pace a lot quicker and those shots will come a little bit more natural, come a little bit more easier. You'll have more rhythm shots, more rhythm opportunities."


text:
ST. FLORIAN, Austria and SAN MARCOS, Texas, U.S. -- EV Group (EVG), a leading supplier of wafer bonding and lithography equipment for the MEMS, nanotechnology and semiconductor markets, has installed an EVG501 wafer bonding system to Texas State University. The highly flexible R&D system, which is configurable for a variety of wafer bonding processes, has been installed in the university's cleanroom facilities to support advanced compound semiconductor and silicon-based power device research and development.
"Following a thorough evaluation of a number of wafer bonding systems, we selected EVG's solution for its superior technology capabilities. The affordable R&D system demonstrated outstanding results, with high pressure conformity and bond consistency," said Edwin Piner, Associate Professor, Physics, at Texas State University. "EVG has a strong support network and we will work closely with their experienced process teams to further the development of bonding processes for specialized compounds."
The EVG501 wafer bonding system can handle small substrate pieces up to 200-mm wafers and supports a variety of bonding processes, such as anodic, glass frit, eutectic, diffusion, fusion, solder and adhesive bonds, as well as other thermal processes, including oxide removal and high-temperature bakes under a controlled atmosphere. The system also offers quick re-tooling with a conversion time of less than five minutes, making it ideal for universities and R&D as well as small-volume production applications.
Garrett Oakes, North American Director of Technology for EV Group, commented, "Working with Texas State marks a further step in our partnering with leading universities and research firms around the world in their efforts to develop solutions to today's challenges as well as exploring advancements that will address future industrial needs. We look forward to a long-term collaborative partnership with Texas State University."
Texas State University is an emerging research university located in the Austin-San Antonio corridor on the edge of the Texas Hill Country. With an enrollment of 34,229, it is the largest campus in the Texas State University System and has been named one of America's Best Value Colleges by the Princeton Review.
EV Group (EVG) is a leading supplier of equipment and process solutions for the manufacture of semiconductors, microelectromechanical systems (MEMS), compound semiconductors, power devices and nanotechnology devices. Key products include wafer bonding, thin-wafer processing, lithography/nanoimprint lithography (NIL) and metrology equipment, as well as photoresist coaters, cleaners and inspection systems. Founded in 1980, EV Group services and supports an elaborate network of global customers and partners all over the world.
Source: EVG


text:
Health Care Reform
Obama Health Reform Plan
- President Obama's Health Care Agenda
- Comparisons of Congressional Health Bills
- Final Health Bill Signed into Law March 2010
- John Goodman's Election Period Commentary
- Obama's Health Care Proposal
- Obama's Plan During and After the Campaign
- Other Voices on Obama's Health Proposal
- Post-Election Details
- Senator Baucus' Vision for Health Care Reform
- Senator Kennedy's Vision for Health Care Reform
- Tom Daschle's Vision for Health Care Reform
Critiques of Obama Health Plan
- A Public Plan would Crowd Out Private Coverage
- Comparative Effectiveness
- Do Any Demand-Side Reforms Actually Work?
- Goodman Health Blog on Health Reform
- Health Care Reform is not a Stimulus
- Health Care Reform Analysis
- Providers and Insurers Respond to Health Care Reform
- How Should We Pay for Healthcare Reform?
- Making the Obama Plan better
- Republican Health Care Reform
- Should there be a Public Plan Option that Competes with Private Insurers?
- Should We Have a National Health Board Determine Treatments?
- Why Massachusetts is not a Model for Health Care Reform
- Will Mandated Health Insurance Work?
This page is a work in progress on Health Care Reform. Additional information will be added as it becomes available.


text:
Gov. Scott in Sanford
Gov. Rick Scott delivers remarks at .decimal, Inc. (pronounced "dot-decimal") during a visit to the medical device manufacturer's facility in Sanford, Monday, April 29, 2013. Scott was pitching his his plan to eliminate sales taxes that manufacturers pay on equipment purchases in Florida. The company makes radiation therapy products for cancer treatments. (Joe Burbank/Orlando Sentinel) newsgate CCI ID: B582889168Z.1
Joe Burbank
Copyright © 2019, Capital Gazette, a Baltimore Sun Media Group publication | Privacy Policy


text:
Phase I Study of Olaparib and Temozolomide for Ewings Sarcoma
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01858168
Recruitment Status : Recruiting
First Posted : May 21, 2013
Last Update Posted : December 12, 2018
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
This research study is a Two arm Phase I clinical trial, which tests the safety of an investigational drug or combination of drugs and also tries to define the appropriate dose of the combination of investigational drugs to use for further studies. "Investigational" means that the combination of drugs is being studied. It also means that the FDA has not yet approved the combination of drugs for your type of cancer.
Olaparib works by blocking the activity of a protein called poly (ADP-ribose) polymerase (PARP) which is involved in DNA repair. Cancer cells rely on PARP to repair their DNA and enable them to continue dividing. Olaparib has been used in research studies with other cancers. Information from those other research studies suggests that this drug may help to treat patients with Ewing's sarcoma. The investigational drug olaparib is not approved for any use outside of research studies.
Temozolomide (Temodar) is approved by the FDA for the treatment of a type of brain tumor, glioblastoma. It has been studied in Ewing sarcoma in previous research studies. While it is not approved by the FDA for Ewing sarcoma, it is considered part of standard treatment for relapsed disease.
Irinotecan is approved by the FDA for the treatment of gastrointestinal cancers. It has been studied in Ewing sarcoma in previous research studies. While it is not approved by the FDA for Ewing sarcoma, it is considered part of standard treatment for relapsed disease.
Laboratory studies suggest that the combination of olaparib and temozolomide and irinotecan may help kill Ewing sarcoma cells.
In this research study, the investigators are looking for the highest dose of the combination of olaparib and irinotecan and/or temozolomide that can be given safely. The investigators will also begin to collect information about the effects of the combination on Ewing sarcoma.
|Condition or disease
|Ewing Sarcoma
|Drug: Olaparib Drug: Temozolomide Drug: Irinotecan
|Phase 1
Show Detailed Description
|Study Type :
|Interventional (Clinical Trial)
|Estimated Enrollment :
|93 participants
|Intervention Model:
|Parallel Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Phase I Study of Olaparib and Temozolomide in Adult Patients With Recurrent/Metastatic Ewing's Sarcoma Following Failure of Prior Chemotherapy
|Study Start Date :
|July 2013
|Estimated Primary Completion Date :
|July 2019
|Estimated Study Completion Date :
|July 2020
Experimental: One
Olaparib, taken orally twice per day on days 1-7 (week 1) of each cycle Temozolomide, taken orally once per day on days 1-7 (week 1) of each cycle
Drug: Olaparib
Tablets to be taken on an empty stomach twice a day.
Other Name: AZD2281
Drug: Temozolomide
Tablets to be taken on an empty stomach before bedtime.
Other Names:
Experimental: Two
Olaparib, taken orally twice per day on days 1-7 (week 1) of each cycle Temozolomide, taken orally once per day on days 1-7 (week 1) of each cycle Irinotecan, given by IV once per day on days 1-7 of each cycle
Drug: Olaparib
Tablets to be taken on an empty stomach twice a day.
Other Name: AZD2281
Drug: Temozolomide
Tablets to be taken on an empty stomach before bedtime.
Other Names:
Drug: Irinotecan
Administered via IV
Other Name: Camptosar
- Determine MTD of olaparib and irinotecan and/or temozolomide [ Time Frame: 30 days ]Determine the Maximum Tolerated Dose of combine oral administration of olaparib and temozolomide.
- Evaluate safety and tolerability of olaparib/irinotecan and/or temozolomide combination [ Time Frame: 2 years ]Evaluate the safety and tolerability of combination olaparib/temozolomide as defined by CTC version 4.0
- Objective response in tumor dimensions to olaparib/irinotecan and/or temozolomide [ Time Frame: 2 years ]Observe objective response in tumor dimensions to olaparib/temozolomide therapy as determined by RECIST 1.1, time of progression free survival (PFS) and overall survival (OS)
- Explore variations in PARP activity and tumor characteristics [ Time Frame: 2 years ]Patients will undergo tumor biopsies before and after starting olaparib and temozolomide therapy. Genomic DNA and RNA will be isolated from these samples and slides will be made to identify specific protein levels. The investigators will assess homologous repair status by measuring gammaH2AX and Rad51 focus formation by immunofluorescence. Biomarkers for apoptosis and DNA repair that the investigators plan to analyze include but are not limited to BRCA1, MRE11A, NBS1, TDG, XPA, Rad50, 53BP1, CHEK2, and MK2.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|16 Years and older (Child, Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Histologically confirmed Ewing's sarcoma
- Ewing's sarcoma must have progressed following at least one standard prior chemotherapy regimen
- Life expectancy of at least 16 weeks
- Willing to comply with the protocol for the duration of the study including pre- and post-treatment biopsies, undergoing treatment, scheduled visits and examinations including follow up
- Presence of measurable disease
- Prior approval from insurance company to obtain oral temozolomide for the duration of the study
Exclusion Criteria:
- Involvement in the planning and/or conduct of the study
- Previous enrollment in the present study
- Participation in another clinical study with an investigational product during the 21 days prior to first dose of olaparib and temozolomide
- Receiving any systemic chemotherapy, radiotherapy (except for palliative reasons), within 2 weeks from the last dose prior to study treatment
- Concurrent use of the following classes of inhibitors of CYP3A4: azole antifungals, macrolide antibiotics, protease inhibitors
- Persistent clinically significant toxicities caused by previous cancer therapy
- Previously documented diagnosis of myelodysplastic syndrome (or any dysplastic leukocyte morphology suggestive of MDS) or acute myeloid leukemia
- Symptomatic uncontrolled brain metastases
- Major surgery within 14 days of starting study treatment
- Considered a poor medical risk due to a serious, uncontrolled medical disorder, non-malignant systemic disease or active, uncontrolled infection
- Unable to swallow orally administered medication and subjects with gastrointestinal disorders likely to interfere with absorption of study medication
- Pregnant or breastfeeding
- Known to be serologically positive for HIV and receiving antiviral therapy
- Subjects with known active hepatitis B or C
- Known hypersensitivity to olaparib or any of the excipients of the product
- Uncontrolled seizures
- Need to continue treatment with any prohibited medications or have not completed the appropriate washout period for a prohibited medication
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01858168
|Contact: Barbara Anderson, RN
|United States, Massachusetts
|Massachusetts General Hospital
|Boston, Massachusetts, United States, 02114
|Contact: Barbara Anderson, RN 617-724-4000 email@example.com
|Contact: Sienna Durbin, BS 617-724-4000
|Principal Investigator: Edwin Choy, MD, PhD
|Boston Children's Hospital
|Boston, Massachusetts, United States, 02115
|Contact: Steven Dubois, MD 617-632-5460 firstname.lastname@example.com
|Brigham and Women's Hospital
|Boston, Massachusetts, United States, 02215
|Contact: Melissa Hohos, RN 617-582-7162 firstname.lastname@example.com
|Contact: Mark Morley, RN 617-632-3989 firstname.lastname@example.com
|Principal Investigator: George Demetri, MD
|Dana-Farber Cancer Institute
|Boston, Massachusetts, United States, 02215
|Contact: Melissa Hohos, RN 617-582-7162 email@example.com
|Contact: Mark Morley, RN 617-632-3989 firstname.lastname@example.com
|Principal Investigator: George Demetri, MD
|United States, Tennessee
|St. Jude's Children's Research Hospital
|Memphis, Tennessee, United States, 38105
|Contact: Sara Federico, MD 866-278-5833 email@example.com
|Principal Investigator:
|Edwin Choy, MD, PhD
|Massachusetts General Hospital
|Responsible Party:
|Edwin Choy, MD, Prinicipal Investigator, Massachusetts General Hospital
|ClinicalTrials.gov Identifier:
|NCT01858168 History of Changes
|Other Study ID Numbers:
|First Posted:
|May 21, 2013 Key Record Dates
|Last Update Posted:
|December 12, 2018
|Last Verified:
|December 2018
|Individual Participant Data (IPD) Sharing Statement:
|Plan to Share IPD:
Additional relevant MeSH terms:
Sarcoma, Ewing
Neoplasms, Connective and Soft Tissue
Neoplasms by Histologic Type
Neoplasms, Bone Tissue
Neoplasms, Connective Tissue
Topoisomerase I Inhibitors
Topoisomerase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents
Antineoplastic Agents, Alkylating
Alkylating Agents
Poly(ADP-ribose) Polymerase Inhibitors


text:
Model : DE-12-24Manufacturer : MACtac
Model : WCH-1212Manufacturer : MACtac
Model : WCH-1224Manufacturer : MACtac
Sign Supply Canada was founded in 1995. For over 20 years, we have been providing equipment and supplies for signs and textile businesses for our fellow Canadian clients. Currently we carry on many top brands sign equipment and supplies, such as GCC, GRAPHTEC, MACTAC, HOTRONIX, GEO KNIGHT, SILHOUETTE, SISER, CHEMICA, TAPE TECHNOLOGY, R-TAPE, MAIN-TAPE, PRESTO-TAPE, FLEXI, SIGNGO, EASYSIGN and etc.
Digital Graphic Inc
6635 Kitimat Rd, Unit 42
Mississauga, ON, L5N 6J2, CA
Call Us : 905-608-2680
Email Us :
Fax :
© 2016 Sign Supply Canada . All Rights Reserved.


text:
WASHINGTON – The Senate approved a 2005 Budget Resolution that could reduce government outlays on farm programs while increasing defense spending and making it easier to pass new tax cuts.
The non-binding resolution, which passed by a vote of 57-45, includes an amendment authored by Sen. Charles Grassley, R-Iowa, which supposedly would free up $1.2 billion by imposing new payment limitations on farm program spending. The savings would go to conservation and nutrition programs.
Senate Democrats, claiming that the Republican-sponsored resolution would provide for additional tax cuts at a time when the federal deficit is projects to exceed $500 billion, offered amendments calling for increased spending on domestic programs and homeland security.
The Senate rejected those amendments, passing a resolution (S Con Res 95) that would limit 2005 discretionary spending to $821 billion, $2 billion less than the President's budget, and give procedural protection for a five-year tax cut package. Procedural protection means the latter would not be subject to a 60-vote requirement for passage.
During the two days of floor debate, Sens. Thad Cochran, R-Miss., and Saxby Chambliss, R-Ga., criticized the Grassley payment limit amendment, saying it would treat farmers in certain regions unfairly.
Chambliss used an amendment, which would require benefits from ethanol tax subsidies to be included as benefits for purposes of applying limitations on farm program benefits, to illustrate the inequity of lower limits on crops with high production costs.
Under Grassley's latest proposal, Congress could reduce limits on direct payments to $20,000 from $40,000; reducing limits on counter-cyclical payments from $65,000 to $30,000 and including the value of certificate redemptions and forfeitures in a $100,000 limit on marketing loan gains.
The non-binding resolution would require enabling action from the Agriculture Committees of both Houses.
Long an opponent of unreasonable, inequitable limitations on farm program benefits, Chambliss noted that the substantial benefits from tax exemptions on ethanol production are not included in current limits or in the Iowa senator's proposal.
Sen. Cochran said the 2002 farm bill included strict limits, added a new adjusted gross income test and created a special commission, which recommended that any changes to limitations not be made until the next farm bill. He also reminded his colleagues that the Budget Resolution was not an appropriate vehicle to mandate changes to current farm law.
Though non-binding, the budget resolution does provide Appropriations committees a figure that limits total discretionary spending. That amount is allocated among 13 subcommittees, including agriculture. The resolution also establishes a total figure for tax cuts but does not specify which cuts are to be made.
The Senate resolution includes a provision that will allow approval of up to $82.1 billion in cuts by a majority vote. Without the procedural protection, any legislation authorizing extension of expiring tax cuts could face a 60-vote hurdle.


text:
When you're looking for a mental health professional in Buffalo, there are many options. Don't let the process of searching for a therapist become frustrating. Browse the profiles and blogs of TherapyTribe's community of experts; then use the quick list feature to select a handful of therapists that meet your needs. You may need to contact more than one therapist to find the right professional for you. Whether you're looking for individual counseling or group therapy, Buffalo therapists are here to help you through the hard times in your life.
Buffalo has an estimated population of 259,384 people. A high population leads to a broad spectrum of mental health needs in the city. While the city itself is urban, it is surrounded by a rural community. Many in the community deal with problems that require them to seek counseling for themselves or their families. For example, there are approximately 7,100 reports of domestic violence per year in the area. As anxiety and depression have become constants in the lives of many, the need for great mental health care has increased. Luckily, many mental health professionals are standing up to the call.
If you believe you need help with any mental health issue, but aren't sure about what steps to take, places such as the National Alliance on Mental Health have chapters by state that can provide information. There are many reasons you may decide it is time to seek therapy for yourself or someone else in your home. Stress, anxiety, and substance abuse are leading causes in the Buffalo area for therapy. The high percentage of unwanted teen pregnancies may also lead you to get counseling for yourself or a family member.
If you have been through a tragedy or trauma, it is a good idea to seek therapy. If it has become difficult to get through everyday life without fears and overwhelming stress, seeing a therapist can put you on the path to wellness.
Finding the right mental health professional is important. You need to make sure that you find someone who you are comfortable around. When you're considering a new therapist, think about what type of people make you feel the most comfortable. Are you more at ease talking with a man or a woman? Are you interested in someone who will lead the discussion, or let you take the lead?
Understanding your needs, and the approach of the therapist will help you find the right person quickly. It's also important to understand that you can find a new therapist if the one you choose doesn't fit your needs. In addition to finding someone who you are comfortable with, make sure that your mental health professional accepts your insurance, since not all insurance plans cover every therapist.
Seeking a mental health professional is a step in the right direction if you are having difficulty coping with your everyday life. Whether you live in the city of Buffalo or in one of the surrounding areas, use the TherapyTribe community to find the right therapist or mental health professional to help you through any problem you are facing.