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Gene Expression - The Journal of Liver Research
Editor-in-Chief: Satdarshan (Paul) S. Monga
Volume 19, 2019
3 numbers per volume
- Aims &
- Submitting
- Tables of
- Editorial
- Author & Subject
- Publishing
- Abstracts
- Full Text
- Order Back Issues
- Press Releases
- Journal
Aims and Scope
Gene Expression, The Journal of Liver Research will publish articles in all aspects of hepatology. Hepatology, as a research discipline, has seen unprecedented growth especially in the cellular and molecular mechanisms of hepatic health and disease, which continues to have a major impact on understanding liver development, stem cells, carcinogenesis, tissue engineering, injury, repair, regeneration, immunology, metabolism, fibrosis, and transplantation. Continued research and improved understanding in these areas will have a meaningful impact on liver disease prevention, diagnosis, and treatment. The existing journal Gene Expression has expanded its focus to become Gene Expression, The Journal of Liver Research to meet this growing demand. In its revised and expanded scope, the journal will publish high-impact original articles, reviews, short but complete articles, and special articles (editorials, commentaries, opinions) on all aspects of hepatology, making it a unique and invaluable resource for readers interested in this field. The expanded team, led by an Editor-in-Chief who is uniquely qualified and a renowned expert, along with a dynamic and functional editorial board, is determined to make this a premier journal in the field of hepatology.
Supplementary Material: Please note that Gene Expression: The Journal of Liver Research discourages and hence is unable to host supplementary material. If you wish to include supplementary material, then you will need to provide a link within the manuscript to a permanent hosting site of this material.
Submission Requirements: Authors are required to submit the original manuscript or revised manuscript via ManuscriptCentral website at https://mc.manuscriptcentral.com/cogcomm-ge. Once accepted your manuscript will require a submission fee of $90.00, which will be billed along with your open access charges upon publication.
Please include a cover letter, containing the name, address, telephone, and electronic mail address of the author (or authors) responsible for correspondence. Follow the General Form guidelines below to prepare the manuscript, figures, and tables.
At the time of submission you will be asked to:
1. Confirm you will pay the open access fees ($1,200.00 for 10 pages or less and $100.00 for each additional page over 10 pages) when billed.
2. Disclose any conflicts of interest and financial support.
3. Agree that you as corresponding/submitting author have the permission of the other authors to submit the manuscript.
4. Affirm that all work performed with animals in the manuscript has been approved by the appropriate authority at your institute. Any patient analysis included in the manuscript must also be approved by the appropriate authority within your institution. Please make sure this is appropriately stated in the text of the manuscript, when applicable.
On receipt of your manuscript, it will be checked to ensure that it is correctly formatted (please see below for additional information on formatting of the manuscript, including general organization, figures and tables). All articles (invited or otherwise) will go through an editorial and a peer-review process. Final decisions will be made by the Editor-in-Chief, based on the recommendation of the Associate Editors and Reviewers.
When the manuscript is accepted for publication, the author(s) will be required to provide a clean electronic copy of the manuscript including any figures as image files at the appropriate resolution (see Final Accepted Manuscript and Figure Files sections below).
Supplementary Material: Please note that Gene Expression: The Journal of Liver Research discourages and hence is unable to host supplementary material. If you wish to include supplementary material, then you will need to provide a link within the manuscript to a permanent hosting site of this material.
General Formatting: Papers should be typed in English, double spaced throughout with at least 3-cm margins on paper approximately 22 × 28 cm (8 1/2 × 11 in.) in size. Number all pages consecutively, beginning with the title page. Use metric units of measure; other units may be given in parentheses.
Title Page: The title should be brief and specific. The title page should contain, in the following order: title; name(s) and affiliation(s) of author(s) including department, institution, city, state, and country; and a suggested running head of around 50 characters including spaces. Also indicate the author to whom correspondence should be addressed, with complete postal mailing address, telephone and fax numbers, and e-mail (necessary for sending proof). In general, no more than two shared first and/or senior authorships can be considered, and they must be appropriately justified in the letter to the editor at the time of submission. The rule can be reassessed on a case-by-case basis for manuscripts arising from multicenter collaborations, but please note that the publishers will not list more than two corresponding authors. In the case of two listed corresponding authors, the proof will only be sent to the first mentioned corresponding author. Please add abstract word count, total number of figures and tables, and other relevant information to the title page.
Text: The authors should make an effort to be concise and systematic throughout the text. Unnecessary jargon should be avoided. All nonstandard abbreviations should be defined when used for the first time in text. When applicable, the Materials and Methods section should be sufficiently detailed and should allow readers to be able to replicate the study.
References: Literature cited should be prepared according to the Council of Science Editors format (citation-sequence system). This format is conveniently in Endnote, and the output style is available at the following site: http://endnote.com/downloads/style/cse-style-manual-7th-ed-citation-sequence. Some examples are provided below. References in the text should be cited by superscript number separated by a comma and listed in numerical order as they appear in the text (double spaced) on a separate page at the end of the manuscript. Journal citations in the reference list should contain the following: (a) reference number (note NOT superscript); (b) surnames and initials of all authors (surnames precede initials); (c) title of article; (d) journal title abbreviated as listed in ISSN.org; (e) year; volume, inclusive pages. See the examples shown and refer to Council of Science Editors format for more examples. (Note there is no punctuation in journal titles if the last word in the journal title is not an abbreviation.)
Journal Article: Sanchez-Valle V, Chavez-Tapia NC, Uribe M, Mendez-Sanchez N. Role of oxidative stress and molecular changes in liver fibrosis: A review. Curr Med Chem. 2012;19:4850–60.
Book Article/Chapter: Huang J, Borensztajn J, Reddy JK. Hepatic lipid metabolism. In: Monga SPS, editor. Molecular pathology of liver diseases. New York (NY): Springer; 2011. p. 133–46.
Book: Heather MC, Abigail, EM, National Research Council. Hepatitis and liver cancer: A national strategy for prevention and control of hepatitis B and C. Washington (DC): The National Academies Press; 2010.
Internet Source: A multicenter phase I study of MRX34, MicroRNA miRRX34 liposome injectable suspension [Internet]. U.S. National Institutes of Health; 2013 [cited October 2013]. Available from http://clinicaltrials.gov/ct2/show/NCT01829971?term=mirna+therapeutics&rank=1
An example of an in-text citation is:
Disturbances in these processes contribute invariably to acute or chronic liver injury1,2.
To cite multiple sources, all numbers associated with the reference being cited should be superscript, separated by a comma, with no spaces between them.
Figures: Figures should be numbered and cited sequentially in the text. Each figure should be provided as a separate file (see Final Figure Files). Include all parts of a figure (e.g., A, B, etc.) as one file. Do not use light lettering and shading that will not reproduce well. Figure dimensions and scaling should be suitable for reduction (if necessary) to fit column or page size. Care must be taken that letters and other symbols do not become so small that they are illegible when the figure is reduced. Complex formulas should be prepared as illustrations. Do not embed figures within the manuscript text.
Figure Files: Each figure should be provided as a separate file. Simple black-and-white figures (e.g., line graphs, bar graphs, etc.) should be 600 dpi. Halftone and color figures (or combo figures) should be 300 dpi. Final figure files should be submitted as tiff, jpg, or eps format. Please do not include the figure number as part of the figure file (e.g., do not label Figure 1, etc., as part of the figure).
Figure Legends: Each figure legend must have a short title that concisely describes the content of each figure. List all figure legends sequentially on one or more pages at the end of the manuscript text, after the references, and identify all symbols used in the figures. The figure legend should be as clear as possible and should fully describe the contents of the figure. Do not include the figure legend as part of the figure. If the figure is from a previously published article, indicate that permission has been obtained from the original publisher.
Tables: All tables must be created in Microsoft Word. Tables should be numbered and cited sequentially in the text. Prepare each table as a separate page at the end of the manuscript text, after the references. Avoid very wide or long tables that would not fit on a printed page. Each table should have a title, and each column in the table should have a brief heading. Define all abbreviations in the table footnote at the bottom of the table.
Acknowledgements and Disclosures: Please acknowledge any funding support. In addition, all authors need to disclose any conflicts of interest, financial or otherwise, in a separate section before the references. Conflicts of interest may include:
1. Direct ownership of equity or shares in a health care or pharmaceutical company relating to the manuscript, by any author or their immediate family members.
2. Receipt of any form of income by any author or their immediate family members from health care or pharmaceutical companies related to the manuscript within the calendar year preceding original submission.
3. Personal interest such as being an expert witness, public advocate, grantee, consultant, founder, owner, or employee of a health care or pharmaceutical company related to the research.
Use of Animal- and Human-derived tissue: Please confirm within the text that the appropriate ethical and/or regulatory body approved the use of animal- or human-derived tissue (as well as informed consent for humans). With human-derived data, articles are published on the understanding that appropriate measures to protect the privacy of the individuals were undertaken.
Statistics: If statistical analysis was performed, define the tests used in the methods and ensure that it is clear what comparisons are made. Please ensure that appropriate testing was performed when multiple comparisons (i.e., one group compared to more than one other group) were made.
Permissions: If data from any other source is used in tables or figures, it is the responsibility of the author(s) to obtain permission to reproduce such material. Provide proof that permission has been granted from the original publisher and indicate the source.
Final Accepted Manuscript: When the manuscript is accepted for publication, the author(s) must provide through online submission site a clean electronic copy of the manuscript in Word format, and the figure files at the appropriate resolution and format (see Figure Files section above). You will also be asked to sign a Copyright Transfer Form and an Author Option form. Once the final manuscript and signed forms have been received, an unedited version of the manuscript will go online. Later, the manuscript will be copyedited for journal production.
Page Proofs: All material accepted for publication is subject to copy editing. Authors will receive page proofs of articles before publication, along with an Open Access authorization form with the final cost based on the number of printed pages, which will need to be completed and returned before the article can be processed for publication.
Types of Submissions
1. Original Articles
Original articles should describe research in the discipline of hepatology. Manuscripts should be concise, well organized, and written in fluent English.
- While there is no word limit, the authors should be succinct in their content.
- The abstract should be less than 250 words.
- The title should be around 150 characters and running head should be around 50 characters, both including spaces.
- There is no limit on figures or tables; however, the authors should be concise and well organized for the readers to follow and derive maximum benefit of the article.
- No more than 100 references are allowed for an original article.
- Abstract should be organized as: Background or Rationale, Methods, Results, Conclusion. No abbreviations, footnotes, or references should be used in the abstract.
- Provide 5 keywords best describing the work at the bottom of the abstract page.
The overall organization of the article should be as follows:
- Title page
- Abstract
- Background or Introduction
- Materials and Methods
- Results
- Discussion
- Acknowledgements
- References
- Tables
- Figure legends
- Figures
2. Short Original Articles
Short original articles should describe research in the discipline of hepatology and should contain sufficient novelty, a striking observation that does not have to include a complete mechanism. Manuscripts should be concise, well organized, and written in fluent English.
- The manuscript should be no more than 3,000 words, excluding references and abstract.
- The abstract should be less than 250 words. Abstract should be organized as: Background or Rationale, Methods, Results, Conclusion. No abbreviations, footnotes, or references should be used in the abstract.
- The title should be around 150 characters and running head should be around 50 characters, both including spaces.
- There should be no more than 4 figures.
- The authors should attempt to include informative tables, color figures, and diagrams.
- Please limit the number of references.
- Provide 5 keywords best describing the work at the bottom of the abstract page.
The overall organization of the article should be as follows:
- Title page
- Abstract
- Background or Introduction
- Materials and Methods
- Results
- Discussion
- Acknowledgements
- References
- Tables
- Figure legends
- Figures
3. Review Articles
Review articles can either be submitted directly by an author or will be solicited by the editors. The reviews will be on timely, innovative topics with a focus on research in hepatology. Overall, the review articles are expected to be comprehensive, unbiased, and informative.
- There is no word limit for the review article, although authors should be aware that readers always appreciate a concise and informative document.
- No more than 250 references are allowed.
- The authors should attempt to include informative tables, color figures, and diagrams.
- Review articles should also have a title page.
- A section on Future Perspectives would be desirable towards the end of the review.
- At least 5 keywords will be required.
- An abstract of less than 250 words is required.
- The organization of the review article is flexible. Subheadings are encouraged to improve the comprehensibility of the article.
4. Short Review Articles
Short review articles follow the same guidelines as Review articles (see above), however they must adhere to a limit of 3000 words and should contain no more than one figure.
5. Methods, Techniques and Protocols
Methods, techniques, and protocol manuscripts will describe a technique or protocol with illustrations.
- There is no word limit for the methods, techniques, and protocols manuscripts, although authors should be aware that readers always appreciate a concise and informative document.
- No more than 250 references are allowed.
- The authors should attempt to include informative tables, color figures, and diagrams.
- Methods, techniques, and protocols articles should have a title page.
- At least 5 keywords will be required.
- An abstract of less than 250 words is required.
- The organization of the article is flexible. Subheadings are encouraged to improve the comprehensibility of the article.
6. "Thinking out loud"
Thinking out loud articles contain a perspective, an opinion, or a hypothesis based on published observations.
- There is no word limit for "thinking out loud" manuscripts, although authors should be aware that readers always appreciate a concise and informative document.
- No more than 250 references are allowed.
- The authors should attempt to include informative tables, color figures, and diagrams.
- "Thinking out loud" articles should have a title page.
- At least 5 keywords will be required.
- An abstract of less than 250 words is required.
- The organization of the article is flexible. Subheadings are encouraged to improve the comprehensibility of the article.
7. Special Articles: Opinions or Response to Opinions, Commentaries
These special articles will be brief and no longer than 1,500 words (excluding references). These should contain no more than 1 figure, diagram, graphical representation, or table. These articles are meant to highlight or discuss an opinion on a recent high-impact study or a new paradigm, or findings that have been recently discovered. These are solicited articles ONLY and an invitation must come from the Editors-in-Chief, Associate Editors, or Editorial Board members. If an author is interested, they can contact the Editors-in-Chief or Associate Editors to provide a cover letter with the information on what article you would like to cover and briefly summarizing the intent and message of your article. Upon discussion with appropriate experts in the Editorial Board, the editorial office will communicate its decision to allow or disallow such an article. The article should eventually provide a succinct summary of the findings of the recently published study followed by discussion on its implications, advantages, disadvantages, strengths, and weaknesses. If this is an "Opinion" article, the authors of the original study may decide to provide a rebuttal, which may be allowed for publication as well.
These articles will represent a concise summary and perspective on a recently published study in Gene Expression, The Journal of Liver Research. The authors will be invited to write an editorial by the Editors-in-Chief or Associate Editors. These are meant to be brief articles not exceeding 1,500 words (excluding references), up to 25 references with maximum allowed 2 figures or tables.
The publishers and editorial board of Gene Expression, The Journal of Liver Research have adopted the publication ethics and malpractice statements of the Committee on Publication Ethics (COPE) (http://publicationethics.org/resources/guidelines). These guidelines highlight what is expected of authors and what they can expect from the reviewers and editorial board in return. They also provide details of how problems will be handled. Briefly:
Author Responsibilities: Authors listed on a manuscript must have made a significant contribution to the study and/or writing of the manuscript. During revisions, authors cannot be removed without their permission and that of the other authors. All authors must also agree to the addition of new authors. It is the responsibility of the corresponding author to ensure that this occurs.
Financial support and conflicts of interest for all authors must be declared. Further information on this can be obtained from the International Committee for Medical Journal Editors (http://www.icmje.org/).
The reported research must be novel and authentic and the authors should confirm that the same data has not been and is not going to be submitted to another journal (unless already rejected). Statements made in the introduction and discussion should be supported by appropriate references and sufficient experimental detail should be provided to allow for repetition of the study by another group. Plagiarism of the text/data will not be tolerated and could result in retraction of an accepted article. Any text or figures reproduced from another source require the permission of the original copyright holders (normally the publishers).
Any manipulation of figures should be equally applied and described in the text including pseudo coloring and must not change the meaning of the figure.
When humans, animals, or tissue derived from them have been used, then mention of the appropriate ethical approval must be included in the manuscript.
Reviewer Responsibilities: Reviewers are expected to not possess any conflicts of interest with the authors and research. They should review the science objectively and provide recommendations for improvements where necessary. When aware of relevant published work not being cited, the reviewers should recommend inclusion of these references. If the reviewer feels that they would be unable to repeat the study as described, then additional methodological details should be requested. Any unpublished information read by a reviewer should be treated as confidential.
Editorial Responsibilities: The editorial office is expected to select an appropriate number of reviewers for the manuscript so that they can make an informed decision about whether to reject/accept a manuscript. Their decision must be based only on the paper's importance, originality, clarity, and whether it is suitable for the journal. They must not have a conflict of interest with the authors or work described. The anonymity of the reviewers must be maintained.
Should problems come to light after acceptance then the editors agree to promote the publication of corrections and/or retractions as deemed necessary.
NIH Public Access Policy: Cognizant Communication Corporation does not upload manuscripts on the authors' behalf to PubMedCentral. The authors of NIH-funded manuscripts are granted permission to upload the final version of the manuscript themselves to PubMedCentral so that they remain in compliance with the NIH Public Access Policy. A PDF of the article is provided to the Corresponding Author for this purpose. Authors have the opportunity to download their articles from open access files http://www.ingentaconnect.com/content/cog/ge
Publishing Responsibilities: The publishers agree to ensure that to the best of their abilities, the information that they publish is genuine and ethically sound. If publishing ethics issues come to light, not limited to accusations of fraudulent data or plagiarism, during or after the publication process, they will be investigated by the editorial board including contact with the authors' institutions if necessary, so that a decision on the appropriate corrections, clarifications, or retractions can be made. The publishers agree to publish this as necessary so as to maintain the integrity of the academic record.
(Scroll down to view tables of contents for all Volumes and Issues)
Volume 19, Number 2
Blood–Bile Barrier: Morphology, Regulation, and Pathophysiology – 69
Tirthadipa Pradhan-Sundd and Satdarshan Pal Monga
Thinking Out Loud
Biofabrication of Autologous Human Hepatocytes for Transplantation: How Do We Get There? – 89
Nandini Agarwal, Branimir Popovic, Nicole J. Martucci, Nicolas A. Fraunhoffer, and Alejandro Soto-Gutierrez
Original Contributions
Single-Cell Gene Expression Analysis Identifies Chronic Alcohol-Mediated Shift in Hepatocyte Molecular States After Partial Hepatectomy – 97
Sirisha Achanta, Aalap Verma, Ankita Srivastava, Harshavardhan Nilakantan, Jan B. Hoek, and Rajanikanth Vadigepalli
Elimination of Wnt Secretion From Stellate Cells Is Dispensable for Zonation and Development of Liver Fibrosis Following Hepatobiliary Injury – 121
Rong Zhang, Alexander T. Kikuchi, Toshimasa Nakao, Jacquelyn O. Russell, Morgan E. Preziosi, Minakshi Poddar, Sucha Singh, Aaron W. Bell, Steven G. England, and Satdarshan P. Monga
PRMT1-Dependent Macrophage IL-6 Production Is Required for Alcohol-Induced HCC Progression – 137
Jie Zhao, Maura O'Neil, Anusha Vittal, Steven A. Weinman, and Irina Tikhanovich
Therapeutic Efficacy of Vitamin D in Experimental c-MET–β-Catenin-Driven Hepatocellular Cancer – 151
Akiko Matsuda, Kaori Ishiguro, Irene K. Yan, and Tushar Patel
Volume 19, Number 1
Original Contributions
Hepatic Gene Expression During the Perinatal Transition in the Rat 1
Edward Hurley, Valerie Zabala, Joan M. Boylan, Philip A. Gruppuso, and Jennifer A. Sanders
In Atp7b−/− Mice Modeling Wilson's Disease Liver Repopulation With Bone Marrow-Derived Myofibroblasts or Inflammatory Cells and Not Hepatocytes Is Deleterious 15
Yogeshwar Sharma, Jinghua Liu, Kathleen E. Kristian, Antonia Follenzi, and Sanjeev Gupta
Bioinformatics Analysis of Key Differentially Expressed Genes in Nonalcoholic Fatty Liver Disease Mice Models 25
Chao Hou, Wenwen Feng, Shan Wei, Yulin Wang, Xiaoyi Xu, Jin Wei, Ziliang Ma, Yongsheng Du, Jialin Guo, Yu He, Fanyun Kong, Renxian Tang, and Kuiyang Zheng
Heat Stress and Thermal Ablation Induce Local Expression of Nerve Growth Factor Inducible (VGF) in Hepatocytes and Hepatocellular Carcinoma: Preclinical and Clinical Studies 37
Scott M. Thompson, Danielle E. Jondal, Kim A. Butters, Bruce E. Knudsen, Jill L. Anderson, Lewis R. Roberts, Matthew R. Callstrom, and David A Woodrum
Invited Reviews
Cellular Abnormalities and Emerging Biomarkers in Alcohol-Associated Liver Disease 49
Ashwani K. Singal and Shannon M. Bailey
Stress of Strains: Inbred Mice in Liver Research 61
Arlin B. Rogers
Volume 18, Number 3
Invited Review
Liver and Pancreas: Do Similar Embryonic Development and Tissue Organization Lead to Similar Mechanisms of Tumorigenesis? 149
Elsa Ghurburrun, Ivan Borbath, Frédéric P. Lemaigre, and Patrick Jacquemin
Original Contributions
Stat3 Regulates Liver Progenitor Cell-Driven Liver Regeneration in Zebrafish 157
Mehwish Khaliq, Sungjin Ko, Yinzi Liu, Hualin Wang, Yonghua Sun, Lila Solnica-Krezel, and Donghun Shin
Direct Comparison of the Thioacetamide and Azoxymethane Models of Type A Hepatic Encephalopathy in Mice 171
Stephanie Grant, Matthew McMillin, Gabriel Frampton, Anca D. Petrescu, Elaina Williams, Victoria Jaeger, Jessica Kain, and Sharon DeMorrow
HNF4α Regulates CSAD to Couple Hepatic Taurine Production to Bile Acid Synthesis in Mice 187
Yifeng Wang, David Matye, Nga Nguyen, Yuxia Zhang, and Tiangang Li
α7-nAChR Knockout Mice Decreases Biliary Hyperplasia and Liver Fibrosis in Cholestatic Bile Duct-Ligated Mice 197
Laurent Ehrlich, April O'Brien, Chad Hall, Tori White, Lixian Chen, Nan Wu, Julie Venter, Marinda Scrushy, Muhammad Mubarak, Fanyin Meng, David Dostal, Chaodong Wu, Terry C. Lairmore, Gianfranco Alpini, and Shannon Glaser
Hepatocyte Wnts Are Dispensable During Diethylnitrosamine and Carbon Tetrachloride-Induced Injury and Hepatocellular Cancer 209
Morgan Preziosi, Minakshi Poddar, Sucha Singh, and Satdarshan P. Monga
Volume 18, Number 2
Invited Reviews
Bile Acid Metabolism in Liver Pathobiology 71
John Y. L. Chiang and Jessica M. Ferrell
The Effects of Physical Exercise on Fatty Liver Disease 89
Dirk J. van der Windt, Vikas Sud, Hongji Zhang, Allan Tsung, and Hai Huang
Endocrine Adiponectin–FGF15/19 Axis in Ethanol-Induced Inflammation and Alcoholic Liver Injury 103
Min You, Zhou Zhou, Michael Daniels, and Alvin Jogasuria
Original Contributions
DNA Damage Response Regulates Initiation of Liver Regeneration Following Acetaminophen Overdose 115
Prachi Borude, Bharat Bhushan, and Udayan Apte
Deciphering the Spectrum of Mitochondrial DNA Mutations in Hepatocellular Carcinoma Using High-Throughput Sequencing 125
Chang Yu, Xuefeng Wang, Lifeng Huang, Ying Tong, Lili Chen, Hailong Wu, Qiang Xia, and Xiaoni Kong
The Effect of Selective c-MET Inhibitor on Hepatocellular Carcinoma in the MET-Active, β-Catenin-Mutated Mouse Model 135
Na Zhan, Adeola Adebayo Michael, Kaiyuan Wu, Gang Zeng, Aaron Bell, Junyan Tao, and Satdarshan P. Monga
Volume 18, Number 1
Coffee Consumption and Prevention of Cirrhosis: In Support of the Caffeine Hypothesis 1
Jonathan A. Dranoff
Invited Reviews
Updates on Dietary Models of Nonalcoholic Fatty Liver Disease: Current Studies and Insights 5
Kristen Stephenson, Lindsey Kennedy, Laura Hargrove, Jennifer Demieville, Joanne Thomson, Gianfranco Alpini, and Heather Francis
Acetaminophen Toxicity: Novel Insights Into Mechanisms and Future Perspectives 19
Anup Ramachandran and Hartmut Jaeschke
Molecular Mechanisms Driving Cholangiocarcinoma Invasiveness: An Overview 31
Simone Brivio, Massimiliano Cadamuro, Luca Fabris, and Mario Strazzabosco
Original Contributions
Oct4 Is Crucial for Transdifferentiation of Hepatocytes to Biliary Epithelial Cells in an In Vitro Organoid Culture Model 51
Mboya Doffou, George Adams, William C. Bowen, Shirish Paranjpe, Harish S. Parihar, Huy Nguyen, George K. Michalopoulos, and Vishakha S. Bhave
Analysis of Naturally Occurring Resistance-Associated Variants to NS3/4A Protein Inhibitors, NS5A Protein Inhibitors, and NS5B Polymerase Inhibitors in Patients With Chronic Hepatitis C 63
Danhui Sun, Mingjia Dai, Shanshan Shen, Chunyang Li, and Xuebing Yan
Volume 17, Number 4
Invited Reviews
GC-1: A Thyromimetic With Multiple Therapeutic Applications in Liver Disease 265
Amedeo Columbano, Grazia Chiellini, and Marta Anna Kowalik
Hepatic Ischemia/Reperfusion: Mechanisms of Tissue Injury, Repair, and Regeneration 277
Takanori Konishi and Alex B. Lentsch
Original Contributions
Gene Expression in the Liver Remnant Is Significantly Affected by the Size of Partial Hepatectomy: An Experimental Rat Study 289
Michelle Meier, Anders Riegels Knudsen, Kasper Jarlhelt Andersen, Niels Christian Bjerregaard, Uffe Birk Jensen, and Frank Viborg Mortensen
Cell Death and Prognosis of Mortality in Alcoholic Hepatitis Patients Using Plasma Keratin-18 301
Benjamin L. Woolbright, Brian W. Bridges, Winston Dunn, Jody C. Olson, Steven A. Weinman, and Hartmut Jaeschke
Increased YAP Activation Is Associated With Hepatic Cyst Epithelial Cell Proliferation in ARPKD/CHF 313
Lu Jiang, Lina Sun, Genea Edwards, Michael Manley Jr., Darren P. Wallace, Seth Septer, Chirag Manohar, Michele T. Pritchard, and Udayan Apte
The Cholangiocyte Adenosine–IL-6 Axis Regulates Survival During Biliary Cirrhosis 327
Elise G. Lavoie, Michel Fausther, Jessica R. Goree, and Jonathan A. Dranoff
Volume 17 Subject and Author Index 341
Volume 17, Number 3
Invited Review
Animal Models of Alcoholic Liver Disease: Pathogenesis and Clinical Relevance 173
Bin Gao, Ming-Jiang Xu, Adeline Bertola, Hua Wang, Zhou Zhou, and Suthat Liangpunsakul
Original Contributions
C57BL/6 Substrains Exhibit Different Responses to Acute Carbon Tetrachloride Exposure: Implications for Work Involving Transgenic Mice 187
Jennifer M. McCracken, Prabhakar Chalise, Shawn M. Briley, Katie L. Dennis, Lu Jiang, Francesca E. Duncan, and Michele T. Pritchard
The Thyromimetic KB2115 (Eprotirome) Induces Rat Hepatocyte Proliferation 207
Marta Szydlowska, Monica Pibiri, Andrea Perra, Elisabetta Puliga, Sandra Mattu, Giovanna M. Ledda-Columbano, Amedeo Columbano, and Vera P. Leoni
Role and Regulation of p65/β-Catenin Association During Liver Injury and Regeneration: A "Complex" Relationship 219
Kari Nejak-Bowen, Akshata Moghe, Pamela Cornuet, Morgan Preziosi, Shanmugam Nagarajan, and Satdarshan P. Monga
tomm22 Knockdown-Mediated Hepatocyte Damages Elicit Both the Formation of Hybrid Hepatocytes and Biliary Conversion to Hepatocytes in Zebrafish Larvae 237
Jianchen Wu, Tae-Young Choi, and Donghun Shin
A Review of the Scaffold Protein Menin and its Role in Hepatobiliary Pathology 251
Laurent Ehrlich, Chad Hall, Fanyin Meng, Terry Lairmore, Gianfranco Alpini, and Shannon Glaser
Volume 17, Number 2
Original Contributions
Differential Expression of MicroRNAs in Hepatitis C Virus-Mediated Liver Disease Between African Americans and Caucasians: Implications for Racial Health Disparities 89
Pradip B. Devhare, Robert Steele, Adrian M. Di Bisceglie, David E. Kaplan, and Ratna B. Ray
Knockdown of miR-23, miR-27, and miR-24 Alters Fetal Liver Development and Blocks Fibrosis in Mice 99
Charles E. Rogler, Joe S. Matarlo, Brian Kosmyna, Daniel Fulop, and Leslie E. Rogler
Bile Duct Ligation Induces ATZ Globule Clearance in a Mouse Model of a-1 Antitrypsin Deficiency 115
Zahida Khan, Shinichiro Yokota, Yoshihiro Ono, Aaron W. Bell, Michael Oertel, Donna B. Stolz, and George K. Michalopoulos
Sorafenib and 2-Deoxyglucose Synergistically Inhibit Proliferation of Both Sorafenib-Sensitive and -Resistant HCC Cells by Inhibiting ATP Production 129
Ryan Reyes, Nissar A. Wani, Kalpana Ghoshal, Samson T. Jacob, and Tasneem Motiwala
Novel Advances in Understanding of Molecular Pathogenesis of Hepatoblastoma: A Wnt/b-Catenin Perspective 141
Danielle Bell, Sarangarajan Ranganathan, Junyan Tao, and Satdarshan P. Monga
Regulators of Cholangiocyte Proliferation 155
Chad Hall, Keisaku Sato, Nan Wu, Tianhao Zhou, Konstantina Kyritsi, Fanyin Meng, Shannon Glaser, and Gianfranco Alpini
Volume 17, Number 1
Editorial 1
Samson T. Jacob, Ph.D. and Satdarshan (Paul) S. Monga, M.D., Editors-in-Chief
Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver 7
Kate Townsend Creasy, Jieyun Jiang, Hui Ren, Martha L. Peterson, and Brett T. Spear
Thyroid Hormone Receptor β Agonist Induces β-Catenin-Dependent Hepatocyte Proliferation in Mice: Implications in Hepatic Regeneration 19
Tamara Feliciano Alvarado, Elisabetta Puliga, Morgan Preziosi, Minakshi Poddar, Sucha Singh, Amedeo Columbano, Kari Nejak-Bowen, and Satdarshan P. S. Monga
Liver-Specific Deletion of Integrin-Linked Kinase in Mice Attenuates Hepatotoxicity and Improves Liver Regeneration After Acetaminophen Overdose 35
Bharat Bhushan, Genea Edwards, Aishwarya Desai, George K. Michalopoulos, and Udayan Apte
Enhanced Steatosis and Fibrosis in Liver of Adult Offspring Exposed to Maternal High-Fat Diet 47
Michael D. Thompson, Mary J. Cismowski, Aaron J. Trask, Scott W. Lallier, Amanda E. Graf, Lynette K. Rogers, Pamela A. Lucchesi, and David R. Brigstock
Myeloid Mixed Lineage Kinase 3 Contributes to Chronic Ethanol-Induced Inflammation and Hepatocyte Injury in Mice 61
Rebecca L. McCullough, Paramananda Saikia, Katherine A. Pollard, Megan R. McMullen, Laura E. Nagy, and Sanjoy Roychowdhury
FAK Kinase Activity Is Required for the Progression of c-MET/β-Catenin-Driven Hepataocellular Carcinoma 79
Na Shang, Maribel Arteaga, Ali Zaidi, Scott J. Cotler, Peter Breslin, Xianzhong Ding, Paul Kuo, Michael Nishimura, Jiwang Zhang, and Wei Qiu
Volume 16, Number 4
Role of Noncoding RNAs as Biomarker and Therapeutic Targets for Liver Fibrosis 155
Kun-Yu Teng and Kalpana Ghoshal
GATA3 in Breast Cancer: Tumor Suppressor or Oncogene? 163
Motoki Takaku, Sara A. Grimm, and Paul A. Wade
Short Report
Cord Blood-Derived Quiescent CD34+ Cells Are More Transcriptionally Matched to AML Blasts Than Cytokine-Induced Normal Human Hematopoietic CD34+ Cells 169
Chinmay Munje, Robert K. Hills, Anthony Whetton, Alan K. Burnett, Richard L. Darley, and Alex Tonks
Original Contributions
Association of Genetic Variants of SIRT1 With Type 2 Diabetes Mellitus 177
Junfeng Han, Meilin Wei, Qianqian Wang, Xu Li, Chaoyu Zhu, Yueqin Mao, Li Wei, Yongning Sun, and Weiping Jia
The Histone Acetyltransferase GCN5 Expression Is Elevated and Regulated by c-Myc and E2F1 Transcription Factors in Human Colon Cancer 187
Yan-Wei Yin, Hong-Jian Jin, Wenjing Zhao, Beixue Gao, Jiangao Fang, Junmin Wei, Donna D. Zhang, Jianing Zhang, and Deyu Fang
ELK3 Expression Correlates With Cell Migration, Invasion, and Membrane Type 1-Matrix Metalloproteinase Expression in MDA-MB-231 Breast Cancer Cells 197
Sun-Hee Heo, Je-Yong Lee, Kyung-Min Yang, and Kyung-Soon Park
Volume 16 Subject and Author Index 205
Volume 16, Number 3
Role of Hepatocyte Nuclear Factor 4α (HNF4α) in Cell Proliferation and Cancer 101
Chad Walesky and Udayan Apte
PDGFRα in Liver Pathophysiology: Emerging Roles in Development, Regeneration, Fibrosis, and Cancer 109
Alexander Kikuchi and Satdarshan Pal Monga
The Long Journey of TCL1 Transgenic Mice: Lessons Learned in the Last 15 Years 129
Yuri Pekarsky, Alessandra Drusco, Prasanthi Kumchala, Carlo M. Croce, and Nicola Zanesi
Original Contributions
Single Nucleotide Polymorphisms in HIF-1α Gene and Residual Ridge Resorption (RRR) of Mandible in Korean Population 137
J. Paek, Y. Oh, J. Kim, and J.-H. Lee
Comprehensive Analysis of the GABAergic System Gene Expression Profile in the Anterior Cingulate Cortex of Mice With Paclitaxel-Induced Neuropathic Pain 145
Willias Masocha
Volume 16, Number 2
Samson T. Jacob and Janardan K. Reddy
Role and Regulation of β-Catenin Signaling During Physiological Liver Growth
Satdarshan (Paul) Singh Monga
Med1 Subunit of the Mediator Complex in Nuclear Receptor-Regulated Energy Metabolism, Liver Regeneration, and Hepatocarcinogenesis
Yuzhi Jia, Navin Viswakarma, and Janardan K. Reddy
Hepatic Fibrosis and the Microenvironment: Fertile Soil for Hepatocellular Carcinoma Development
Michael C. Wallace and Scott L. Friedman
Regulation of Glucose Metabolism in Hepatocarcinogenesis by MicroRNAs
Ryan K. Reyes, Tasneem Motiwala, and Samson T. Jacob
Emerging Insights Into the Role of MicroRNAs in the Pathogenesis of Cholangiocarcinoma
Hiroaki Haga, Irene Yan, Kenji Takahashi, Joseph Wood, and Tushar Patel
Volume 16, Number 1
MicroRNAs Synergistically Regulate Milk Fat Synthesis in Mammary Gland Epithelial Cells of Dairy Goats
Xianzi Lin, Jun Luo, Liping Zhang, and Jiangjiang Zhu
Differential Expression of Distinct Surface Markers in Early Endothelial Progenitor Cells and Monocyte-Derived Macrophages
Shu-Meng Cheng, Shing-Jyh Chang, Tsung-Neng Tsai, Chun-Hsien Wu, Wei-Shing Lin, Wen-Yu Lin, and Cheng-Chung Cheng
Tcea3 Regulates the Vascular Differentiation Potential of Mouse Embryonic Stem Cells
Young Cha, Sun-Hee Heo, Hee-Jin Ahn, Seong Kyu Yang, Ji-Hwan Song, Wonhee Suh, and Kyung-Soon Park
Expression of Alcoholism-Relevant Genes in the Liver Are Differently Correlated to Different Parts of the Brain
Lishi Wang, Yue Huang, Yan Jiao, Hong Chen, Yanhong Cao, Beth Bennett, Yongjun Wang, and Weikuan Gu
Determination of Relative Notch1 and γ-Secretase-Related Gene Expression in Puromycin-Treated Microdissected Rat Kidneys
Damir Simic, Frank Simutis, Catherine Euler, Christina Thurby, W. Mike Peden, R. Todd Bunch, Gary Pilcher, Thomas Sanderson, and Terry Van Vleet
Volume 15, Number 5-6
RNA Interference-Mediated Knockdown of DGAT1 Decreases Triglyceride Content of Bovine Mammary Epithelial Cell Line
Chunyan Lu, Runjun Yang, Binglei Shen, Hassan Osman, Yonghong Zhang, Shouqing Yan, Liying Zhang, and Zhihui Zhao
Involvement of ITIH5, a Candidate Gene for Congenital Uterovaginal Aplasia (Mayer-Rokitansky-Küster-Hauser Syndrome), in Female Genital Tract Development
Karine Morcel, Tanguy Watrin, Frédérique Jaffre, Stéphane Deschamps, Francis Omilli, Isabelle Pellerin, Jean Levêque, and Daniel Guerrier
Identification of Genotypes of Plasmid-Encoded AmpC β-Lactamases From Clinical Isolates and Characterization of Mutations in Their Promoter and Attenuator Regions
Gui-Ling Li, Li-Bo Duo, Ying Luan, Cheng-Ying Wang, Wei-Ping Wang, He-Guang Zhang, Qi Sun, and Gui-Yun Qi
Statins Cause Profound Effects on Gene Expression in Human Cancer Cells In Vitro: The Role of Membrane Microdomains
David John Garnett and Trevor James Greenhough
Cystathionine Gamma-Lyase Expression Is Regulated by Exogenous Hydrogen Peroxide in the Mammalian Cells
Maoxian Wang, Zhanyun Guo, and Shilong Wang
Computational Approaches for Identifying Cancer miRNA Expressions
Shubhra Sankar Ray, Jayanta Kumar Pal, and Sankar K. Pal
Volume 15 Subject and Author Index
Volume 15, Number 4
Stable Expression of FoxA1 Promotes Pluripotent P19 Embryonal Carcinoma Cells to Be Neural Stem-Like Cells
Difei Dong, Lei Meng, Qiqi Yu, Guixiang Tan, Miao Ding, and Yongjun Tan
Expression Patterns of Ubiquitin Conjugating Enzyme UbcM2 During Mouse Embryonic Development
Xing Yanjiang, He Hongjuan, Gu Tiantian, Zhang Yan, Huang Zhijun, and Wu Qiong
Genome-Wide Gene Expression Profiling of Human Narcolepsy
Camilla Bernardini, Wanda Lattanzi, Paolo Bosco, Christian Franceschini, Giuseppe Plazzi, Fabrizio Michetti, and Raffaele Ferri
Distribution of Histone3 Lysine 4 Trimethylation at T3-Responsive Loci in the Heart During Reversible Changes in Gene Expression
Kumar Pandya, Takahide Kohro, Imari Mimura, Mika Kobayashi, Youichiro Wada, Tatsuhiko Kodama, and Oliver Smithies
Volume 15, Number 3
Samson T. Jacob
Gene Expression Profiling: Changing Face of Breast Cancer Classification and Management
Robert Wesolowski and Bhuvaneswari Ramaswamy
Role of TGF-b and the Tumor Microenvironment During Mammary Tumorigenesis
Molly A. Taylor, Yong-Hun Lee, and William P. Schiemann
Role of Epithelial Stem/Progenitor Cells in Mammary Cancer
Robert D. Bruno and Gilbert H. Smith
Emerging Role of MicroRNAs in Drug-Resistant Breast Cancer
Sarmila Majumder and Samson T. Jacob
Volume 15, Number 2
Reversible Epigenetic Modifications of the Two Cardiac Myosin Heavy Chain Genes During Changes in Expression
Kumar Pandya, Benjamin Pulli, Scott Bultman, and Oliver Smithies
Differential Allelic Distribution of V-ets Erythroblastosis Virus E26 Oncogene Homolog2 (ETS2) Functional Polymorphisms in Different Group of Patients
Arpita Chatterjee, Samikshan Dutta, Sanjit Mukherjee, Nupur Mukherjee, Sharmila Chandra, Ashis Mukherjee, Swagata Sinha, Chinmay Kumar Panda, Keya Chaudhuri, and Kanchan Mukhopadyay
RNAi Silenced Dd-grp94 (Dictyostelium discoideum Glucose-Regulated Protein 94 kDa) Cell Lines in Dictyostelium Exhibit Marked Reduction in Growth Rate and Delay in Development
Sandhya N. Baviskar and Malcolm S. Shields
Intronic DNA Elements Regulate Androgen-Dependent Expression of the Murine Nkx3.1 Gene
Chinatsu Kojima, Yan Zhang, and Warren E. Zimmer
Volume 15, Number 1
ATF3, a Hub of the Cellular Adaptive-Response Network, in the Pathogenesis of Diseases: Is Modulation of Inflammation a Unifying Component?
Tsonwin Hai, Christopher C. Wolford, and Yi-Seok Chang
Emerging Roles for XBP1, a sUPeR Transcription Factor
Yin He, Shengyi Sun, Haibo Sha, Ziying Liu, Liu Yang, Zhen Xue, Hui Chen, and Ling Qi
Original Contributions
Early Transcriptional Events During Osteogenic Differentiation of Human Bone Marrow Stromal Cells Induced by Lim Mineralization Protein 3
Camilla Bernardini, Nathalie Saulnier, Claudio Parrilla, Enrico Pola, Andrea Gambotto, Fabrizio Michetti, Paul D. Robbins, and Wanda Lattanzi
Domain Within the C Protein of Human Parainfluenza Virus Type 3 That Regulates Interferon Signaling
Hongxia Mao, Santanu Chattopadhyay, and Amiya K. Banerjee
Volume 14, Number 6
Differential Expression of Shh and BMP Signaling in the Potential Conversion of Human Adipose Tissue Stem Cells Into Neuron-Like Cells In Vitro
Alejandra Cardozo, Marcelo Ielpi, Daniel Gómez, and Pablo Argibay
Quantitative Gene Expression Profiles in Real Time From Expressed Sequence Tag Databases
Vincent A. Funari, Konstantin Voevodski, Dimitry Leyfer, Laura Yerkes, Donald Cramer, and Dean R. Tolan
Developmental and Tissue-Specific Regulation of Hepatocyte NuclearFactor 4-α (HNF4-α) Isoforms in Rodents
Samena Dean, Justin I. Tang, Jonathan R. Seckl, and Moffat J. Nyirenda
Transcritpional Effects of S100B on Neuroblastoma Cells: Perturbationof Cholesterol Homeostasis and Interference on the Cell Cycle
C. Bernardini, W. Lattanzi, R. Businaro, S. Leone, V. Corvino, G. Sorci, G. Lauro, L. Fumagalli, R. Donato, and F. Michetti
Identification of a Gene Expression Signature for Survival Predictionin Type I Endometrial Carcinoma
Kristina Levan, Karolina Partheen, Lovisa Österberg, Björn Olsson, Ulla Delle, Saskia Eklind, and György Horvath
Volume 14 Subject and Author Index 371
Volume 14, Numbers 1-5
Satdarshan (Paul) S. Monga, University of Pittsburgh, USA
Senior Editors
Europe – Frédéric Lemaigre, Université catholique de Louvain, Belgium
Asia – Hua Wang, Institute for Liver Diseases of Anhui Medical University, China
United States – Scott Friedman, Mount Sinai, USA
Associate Editors
Bin Gao, NIAAA, NIH, USA
Hongliang Li, Wuhan University, China
Joseph Locker, University of Pittsburgh, USA
George Michalopoulos, University of Pittsburgh, USA
Atsushi Miyajima, University of Tokyo, Japan
Tushar Patel, Mayo Clinic, USA
Steve Weinman, The University of Kansas, USA
Min You, Northeast Ohio Medical University, USA
Editorial Board
Gianfranco Alpini, Indiana University, USA
Frank Anania, Food and Drug Administration, USA
Udayan Apte, The University of Kansas, USA
Gavin Arteel, University of Pittsburgh, USA
Jésus M. Bañales, Biodonostia Institute, San Sebastian, Spain
Ramon Bataller, University of Pittsburgh, USA
Timothy Billiar, University of Pittsburgh, USA
John Chiang, Northeast Ohio Medical University, USA
Amedeo Columbano, Universita di Cagliari, Italy
Carlo Croce, The Ohio State University, USA
Jonathan Dranoff, University of Arkansas for Medical Sciences, USA
Deyu Fang, Northwestern University, USA
Gen-Sheng Feng, University of California, San Diego, USA
Kalpana Ghoshal, The Ohio State University, USA
Sanjeev Gupta, Albert Einstein College of Medicine, USA
Tsonwin Hai, The Ohio State University, USA
Samson T. Jacob, Founding Editor, The Ohio State University, USA
Hartmut Jaeschke, University of Kansas, USA
Won-il Jeong, KAIST, Korea
Xiaoni Kong, Shanghai Jiao Tong University, China
Fouad Lafdi, Inserm, France
Alex Lentsch, University of Cincinnati, USA
Mark McNiven, Mayo Clinic- Rochester, Minnesota, USA
Laura Nagy, Cleveland Clinic, USA
Kari Nejak-Bowen, University of Pittsburgh, USA
Wei Qui, Loyola University of Chicago, USA
Ratna Ray, Saint Louis University, USA
Janardhan Reddy, Northwestern University Medical School, USA
Lewis Roberts, Mayo Clinic- Rochester, Minnesota, USA
David Rudnick, Washington University in St. Louis, USA
Arun Sanyal, Virginia Commonwealth University, USA
Peter Sarnow, Stanford University School of Medicine, USA
Hiroyuki Seimiya, Japanese Foundation for Cancer Research, Japan
Ekihiro Seki, Cedars Sinai, USA
Vijay Shah, Mayo Clinic- Rochester, Minnesota, USA
David Shafritz, Albert Einstein College of Medicine, USA
Donghun Shin, University of Pittsburgh, USA
Ashwani Singal, University of Alabama Birmingham, USA
Christian Trautwein, Aachen University, Germany
Rebecca Wells, University of Pennsylvania, USA
Mingjiang Xu, NIAAA, NIH, USA
Yingzi Yang, Harvard University, USA
George Yeoh, Harry Perkins Institute of Medical Research, Australia
Jessica Zucman-Rossi, French Institute of Health and Medical Research, France
Alpini, G., 155, 251
|Lairmore, T., 251
Lallier, S. W., 47
Lavoie, E. G., 327
Ledda-Columbano, G. M., 207
Lentsch, A. B., 277
Leoni, V. P., 207
Liangpunsakul, S., 173
Lucchesi, P. A., 47
Manley Jr., M., 313
Manohar, C., 313
Matarlo, J. S., 99
Mattu, S., 207
McCraken, J. M., 187
McCullough, R. L., 61
McMullen, M. R., 61
Meier, M., 289
Meng, Fanyin, 155, 251
Michalopoulos, G. K., 35, 115
Moghe, A., 219
Monga, S. P., 1, 19, 141, 219
Mortensen, F. V., 289
Motiwala, T., 129
Nagarajan, S., 219
Nagy, L. E., 61
Nejak-Bowen, K., 19, 219
Nishimura, M., 79
Oertel, M., 115
Olson, J. C., 301
Ono, Y., 115
Perra, A., 207
Peterson, M. L., 7
Pibiri, M., 207
Poddar, M., 19
Pollard, K. A., 61
Preziosi, M., 19, 219
Pritchard, M. T., 187, 313
Puliga, E., 19, 207
Qiu, Wei, 79
Ranganathan, S., 141
Ray, R. B., 89
Ren, Hui, 7
Reyes, R., 129
Rogers, L. K., 47
Rogler, C. E., 99
Rogler, L. E., 99
Roychowdhury, S., 61
Saikia, P., 61
Sato, K., 155
Septer, S., 313
Shang, Na, 79
Shin, Donghun, 237
Singh, S., 19
Spear, B. T., 7
Steele, R., 89
Stolz, D. B., 115
Sun, Lina, 313
Szydlowska, M., 207
|Tao, Junyan, 141
Thompson, M. D., 47
Trask, A. J., 47
Wallace, D. P., 313
Wang, Hua, 173
Wani, N. A., 129
Weinman, S. A., 301
Woolbright, B. L., 301
Wu, Jianchen, 237
Wu, Nan, 155
Xu, Ming-Jiang, 173
Yokota, S., 115
Zaidi, A., 79
Zhang, Ziwang, 79
Zhou, Tianhao, 155
Zhou, Zhou, 173
|Adenosine, 327
Adenosine receptor, 327
African Americans, 89
Alb/TGF-β1, 99
Alcoholic hepatitis (AH), 301
Alcoholic liver disease (ALD), 61, 173
Animal models, 173
Apoptosis, 301
Autophagy, 115
β-Catenin, 35, 219
Biliary cirrhosis, 327
Biliary epithelium, 155, 251
Cancer, 7
Carbon tetrachloride, 187
β-Catenin, 35, 219
Caucasian Americans, 89
Cell fate, 99
Cholangiocarcinoma (CCA), 251
Cholangiocyte, 327
Cholangiopathies, 155
Cholestasis, 115, 155
Cirrhosis, 301
Cyclin D1, 207, 219
Cyst, 313
Cytochrome P450 2E1, 35
Cytokines, 61
2-Deoxyglucose (2DG), 129
Development, 7
Developmental origins of disease, 47
Differentiation, 99
Drug-induced liver injury, 35
Extracellular matrix (ECM), 35
Extracellular receptor kinase (ERK), 79
|Fatty liver, 47
Fibrosis, 47, 251, 313
Gene expression, 289
Glycolysis, 129
Hepatectomy, 289
Hepatic inflammation, 187, 277
Hepatic injury, 187, 277
Hepatic progenitors, 99
Hepatitis C virus (HCV), 89
Hepatocellular carcinoma (HCC), 79, 89, 129, 251, 265
Hepatocyte, 7, 115
Hepatocyte proliferation, 19, 35, 207
High-fat diet (HFD), 47
Hippo kinase, 313
Histone deacetylase, 251
Immunology, 251
Inflammation, 313
Inflammation and injury, 173
Interleukin-6 (IL-6), 327
JunD, 251
Knockout mice, 7
Kupffer cells, 61
Liver, 99
Liver cell proliferation, 265
Liver damage, 155
Liver development, 141
Liver diseases, 173
Liver failure, 289
Liver fibrosis, 99, 327
Liver injury, 219, 301
Liver progenitor cells, 237
Liver regeneration (LR), 115, 187, 219, 237, 277
Liver transplantation, 19
Liver tumor, 141
Macrophage, 237
Metabolic disease, 251
Microarray analysis, 289
MicroRNAs (miRNAs), 89, 99
miR-23, 99
miR-24, 99
Miscellaneous metabolic liver diseases, 173
Mixed lineage leukemia (MLL), 251
Molecular basis, 173
Necroptosis, 61
Necrosis, 277, 301
Oval cells, 237
p65, 219
Pancreas, 251
Partial hepatectomy (PH), 219
Pediatric, 141
PiZZ, 115
Proliferation, 79, 219, 313
|Regeneration, 7, 19, 289
Regenerative medicine, 207, 265
Resistance, 129
Sleeping Beauty transposon system, 79
Sorafenib, 129
Stellate cell activation, 47
Thyroid hormone receptor, 265
Thyromimetics, 207, 265
Toll-like receptor 4 (TLR4), 61
Transcription, 7
Transforming growth factor-β (TGF-β), 251
Tumor necrosis factor-α (TNF-α), 219
Wnt, 219
Wnt pathway, 19
Wnt signaling, 141
Yap, 141
Ahn, Hee-Jin, 25
Jacob, S. T., 49, 85
|Kikuchi, A., 109
Kim, J., 137
Kumchala, P., 129
Lee, J.-H., 137
Lee, Je-Yong, 197
Li, Xu, 177
Lin, Wei-Shing, 15
Lin, Wen-Yu, 15
Lin, Xianzi, 1
Luo, Jun, 1
Mao, Yueqin, 177
Masocha, W., 145
Monga, S. (P.) S., 51, 109
Motiwala, T., 85
Munje, C., 169
Oh, Y., 137
Paek, J., 137
Park, Kyung-Soon, 25, 197
Patel, T., 93
Peden, W. M., 39
Pekarsky, Y., 129
Pilcher, G., 39
Reddy, J. K., 49, 63
Reyes, R. K., 85
Sanderson, T., 39
Simic, D., 39
Simutis, F., 39
Song, Hi-Hwan, 25
Suh, Wonhee, 25
Sun, Yongning, 177
|Takahashi, K., 93
Takaku, M., 163
Teng, Kun-Yu, 155
Thurby, C., 39
Tonks, A., 169
Tsai, Tsung-Neng, 15
Van Vleet, T., 39
Viswakarma, N., 63
Wade, P. A., 163
Walesky, C., 101
Wallace, M. C., 77
Wang, Lishi, 31
Wang, Qianqian, 177
Wang, Yongjun, 31
Wei, Junmin, 187
Wei, Li, 177
Wei, Meilin, 177
Whetton, A., 169
Wood, J., 93
Wu, Chun-Hsien, 15
Yan, I., 93
Yang, Kyung-Min, 197
Yang, Seong Kyu, 25
Yin, Yan-Wei, 187
Zanesi, N., 129
Zhang, Donna D., 187
Zhang, Jianing, 187
Zhang, Liping, 1
Zhao, Wenjing, 187
Zhu, Chaoyu, 177
Zhu, Jiangjiang, 1
|Acute myeloid leukemia (AML), 169
Alcoholism, 31
γ-Aminobutyric acid (GABA), 145
Anterior cingulate cortex (ACC), 145
Atrophy, 137
β-Catenin, 109
B-Cell, 129
Biliary tract cancers, 93
Brain structure, 31
Breast cancer, 163, 197
β-Catenin, 109
Cell cycle, 169
Cell death, 93
Cell proliferation, 93
Chemotherapy-induced neuropathic pain, 145
Chinese Han population, 177
Cholangiocarcinoma, 109
Chronic lymphocytic leukemia (CCL), 129
Cirrhosis, 109
c-Myc, 101, 187
Colon cancer, 187
Cyclin-D1, 51
Dairy goat, 1
Diethylnitrosamine, 101
Early endothelial progenitor cells (EPCs), 15
Edentulous mandible, 137
Epithelial–mesenchymal transition, 93
Extracellular matrix (ECM), 77
Eμ-TCL1, 129
GABA receptor, 145
GABA transporter, 145
γ-Aminobutyric acid (GABA), 145
γ-Secretase, 39
Gene expression, 31
Gene expression profile, 15
Gene expression profiling, 169
Gene transcription, 187
General control nonrepressed protein 5 (GCN5), 187
Genetic variants, 177
Glucose metabolism, 85
Glutamine synthetase, 51
Hematopoietic stem cells, 169
Hepatic fibrosis, 109
Hepatic stellate cells (HSCs), 77
Hepatocarcinogenesis, 63
Hepatocellular carcinoma (HCC), 77, 85, 101, 109
Hepatocytes, 101
|Kidney, 39
Laser capture microdissection (LCM), 39
Lck-TCL1, 129
Liver, 31
Liver development, 51, 109
Liver fibrosis, 77, 155
Liver regeneration, 51, 63, 109
Long noncoding RNAs (lncRNAs), 155
Macrophage, 15
Med1, 63
Mediator complex, 63
Metabolism of milk fat synthesis, 1
Metastasis, 197
MicroRNAs (miRNAs), 85, 155
Monocyte, 15
Mouse embryonic stem cells (mESCs), 25
Mouse models, 129
NF-κB, 109
Noncoding RNAs (ncRNAs), 93, 155
Nonparenchymal cells, 51
Notch, 39
Oncogene, 163
Oxidative stress, 109
Paclitaxel, 145
Platelet-derived growth factor (PDGF), 109
Proliferating cell nuclear antigen (PCNA), 101
Proliferation, 51
Puromycin, 39
Residential ridge resorption (RRR), 137
|γ-Secretase, 39
Single nucleotide polymorphisms (SNPs), 137
Sorafenib, 109
Surface marker, 15
Synergistic miRNAs, 1
Tcea3, 25
Transforming growth factor-β (TGF-β), 109
Tumor suppressor, 163
Type 2 diabetes, 177
Vasculogenesis, 25
Zonation, 51
|Banerjee, A. K., 43
Baviskar, S. N., 75
Bernardini, C., 27, 171
Bosco, P., 171
Bruno, R. D., 133
Bultman, S., 51
Chandra, S., 61
Chang, Y.-S., 1
Chatterjee, A., 61
Chattopadhyay, S., 43
Chaudhuri, K., 61
Chen, H., 13
Deschamps, S., 207
Ding, M., 153
Dong, D., 153
Duo, L., 215
Dutta, S., 61
Ferri, R., 171
Franceschini, C., 171
Gambotto, A., 27
Garnet, D. J., 225
Greenhough, T. J., 225
Guerrier, D., 207
Guo, Z., 235
Hai, T., 1
He, Y., 13
Hongjuan, H., 163
Jacob, S. T., 141
Jaffre, F., 207
Kobayashi, M., 183
Kodama, T., 183
Kohro, T., 183
Kojima, C., 89
|Lattanzi, W., 27, 171
Lee, Y.-H., 117
Levêque, J., 207
Li, G., 215
Liu, Z., 13
Lu, C., 199
Luan, Y., 215
Majumder, S., 141
Mao, H., 43
Meng, L., 153
Michetti, F., 27, 171
Mimura, I., 183
Morcel, K., 207
Mukherjee, A., 61
Mukherjee, N., 61
Mukherjee, S., 61
Mukhopadyay, K., 61
Omilli, F., 207
Osman, H., 199
Pal, J. K., 243
Pal, S. K., 243
Panda, C. K., 61
Pandya, K., 51, 183
Parrilla, C., 27
Pellerin, I., 207
Plazzi, G., 171
Pola, E., 27
Pulli, B., 51
Qi, G., 215
Qi, L., 13
Qiong, W., 163
Ramaswamy, B., 105
Ray, S. S., 243
Robbins, P. D., 27
|Saulnier, N., 27
Schiemann, W. P., 117
Sha, H., 13
Shen, B., 199
Shields, M. S., 75
Sinha, S., 61
Smith, G. H., 133
Smithies, O., 51, 183
Sun, Q., 215
Sun, S., 13
Tan, G., 153
Tan, Y., 153
Taylor, M. A., 117
Tiantian, G., 163
Wada, Y., 183
Wang, C., 215
Wang, M., 235
Wang, S., 235
Wang, W., 215
Watrin, T., 207
Wesolowski, R., 105
Wolford, C. C., 1
Xue, Z., 13
Yan, S., 199
Yan, Z., 163
Yang, L., 13
Yang, R., 199
Yanjiang, X., 163
Yu, Q., 153
Zhang, H., 215
Zhang, L., 199
Zhang, Y., 89
Zhang, Y., 199
Zhao, Z., 199
Zhijun, H., 163
Zimmer, W. E., 89
|Acetylation, 51
Activating transcription factor 3 (ATF3), 1
Acute lymphoblastic leukemia (ALL), 61
Adaptive-response network, 1
AmpC β-lactamases, 215
Androgen receptor, 89
Androgen response element (ARE), 89
Bioinformatics, 243
Biologic behavior, 105
Breast cancer, 61, 105, 133, 141
Breast cancer subtypes, 105
Cancer, 89, 225, 243
Cataplexy, 171
Caveolae, 225
ChIP-seq, 183
Chromatin, 51
Classification, 105
Congenital uterovaginal aplasia, 207
C protein, 43
Cystathionine gamma-lyase, 225
Dictyostelium discoideum glucose regulated 94 kDA protein (Dd-Grp94), 75
Diseases, 13
Down's syndrome, 61
Drug resistance, 141
Endoplasmic reticulum, 75
Epigenetic, 183
Epithelia, 89
Escherichia coli, 215
Extracellular matrix, 207
Female, 207
FoxA1 transcription factor, 153
Gene expression, 27, 171, 225
Gene expression profiling, 105
Glucose-regulated 94 kDA protein (Grp94), 75
Heart, 51, 183
Histone, 51
Histone methylation, 183
Human parainfluenza virus type 3 (HPIV3), 43
Hydrogen peroxide, 235
Hydrogen sulfide, 225
|Inducible, 215
Inflammatory response, 1
Inositol-requiring enzyme 1 (IRE1α), 13
In situ hybridization, 163
Interferon (IFN) antagonist, 43
Klebsiella pneumoniae, 215
Lim mineralization protein-3 (LMP3), 27
Mammary biology, 133
Mammary epithelial cell, 199
Mammary tumorigenesis, 117
Mesenchymal cells, 27
Metastasis, 117
Methylation, 51
Microarray, 27, 171
Microenvironment, 117
MicroRNA expressions, 243
MicroRNAs, 141
Mouse, 207
Mouse embryo development, 163
MRKH syndrome, 207
Myosin heavy chain, 183
Narcolepsy, 171
Nestin, 153
Nkx3.1, 89
Oral cancer, 61
Osteogenesis, 27
Oxidative stress, 235
Pattern recognition, 243
Pluripotent P19 embryonal carcinoma (EC) cells, 153
Pravastatin, 225
Progenitor cells, 133
Prostate, 89
|Rafts, 225
Retinoic acid-induced neuronal differentiation, 153
RNA interference (RNAi), 75, 199
rs1051420, 61
rs1051425, 61
rs461155, 61
Splicing, 13
Stable cell line, 153
Stem cells, 133
Steroid regulation, 89
Thyroid hormone, 51, 183
Transcription, 13
Transforming growth factor-β (TGF-β), 117
Triglyceride (TG), 199
Tumorigenesis, 133
UbcM2, 163
Unfolded protein response (UPR), 13
X-box binding protein 1 (XVP1), 13
|Aaltonen, L. A., 59
Adams, M. E., 47
Albrecht, D. E., 47
Allen, C. E., 83
Arends, M. J., 101
Argibay, P., 307
Auer, H., 83
Ayares, D. L., 251
Barnard, J. A., 83
Bernardini, C., 345
Bernardini, G., 117
Bernd, P., 241
Beuerman, R. W., 265
Biron, S., 35
Bloomston, M., 207
Borensztajn, J., 291
Bossé, Y., 35
Brewer, A. R., 207
Brooks, D. G., 101
Burke, K. A., 23
Businaro, R., 345
Calonge, M., 265
Camarillo, C., 159
Cardozo, A., 307
Cattaneo, A. G., 117
Cavanaugh, A. H., 131
Chan, M.-Y., 149
Chini, V., 117
Corvino, V., 345
Cramer, D., 321
Dean, S., 337
Debata, P. R., 13
Delle, U., 361
Diebold, Y., 265
Diez, J., 279
Donato, R., 345
Du, J., 23
Duncan, A. J., 251
Eklind, S., 361
Ellison, E. C., 207
Evans, A., 131
Farrar, W. B., 207
Feng, G., 47
Frankel, W. L., 207
Froehner, S. C., 47
Fu, L., 251
Fu, T., 291
Fumagalli, L., 345
Funari, V. A., 321
Gamache, C., 23
Gao, J., 265
Garbati, M. R., 195
Garcia, J. G. N., 229
García-Fernández, J. M., 279
Gilmore, T. D., 195
Giraldo, A. M., 251
Gómez, D., 307
Gómez-Baena, G., 279
Gornati, R., 117
Grigoryev, D., 229
Hamoudi, R., 101
Heng, C.-K., 149
Horvath, G., 361
Ielpi, M., 307
Intine, R. V., 71
Jacobson, J., 229
Jalanko, A., 59
Jia, Y., 291
|Kaetzel, D. M., 1
Karhu, A., 59
Kelly, B. B., 47
Kiuru, M., 59
Kurtycz, D., 173
Lattanzi, W., 345
Launonen, V., 59
Lauro, G., 345
Lavoie, T. L., 229
Lebel, S., 35
Lehtonen, H. J., 59
Lehtonen, R., 59
Leone, S., 345
Levan, K., 361
Leyfer, D., 321
Li, H., 229
Li, J., 207
Liu, Y., 83
López-Lozano, A., 279
Lund, B. T., 23
Luo, F., 101
Ma, S.-F., 229
Mahajan, A., 207
Maraia, R. J., 71
Marceau, P., 35
McCorkle, J. R., 1
Mendicino, M., 251
Michetti, F., 345
Miranda, R. C., 159
Mishra, A., 1
Muñoz-Marín, M. D. C., 279
Muscarella, P., 207
Muthusamy, N., 83
Nyirenda, M. J., 337
Olsson, B., 361
Ormerod, A. K., 1
Österberg, L., 361
Panda, H., 13
Panday, R. S., 13
Park, J.-M., 71
Partheen, K., 361
Patek, C. E., 101
Patterson, D., 173
Pedigo, N. G., 1
Peterson, D. A., 183
Qi, Z., 173
Rangel, O. A., 279
Rao, M. S., 291
Reddy, J. K., 291
Richard, D., 35
Richards, J., 83
Robinson, M. L., 83
Rossi, F., 117
Rothblum, L. I., 131
|Saroglia, M., 117
Seckl, J. R., 337
Setterquist, R., 229
Song, Y., 23
Sorci, G., 345
Stern, M. E., 265
Supakar, P. C., 13
Tang, J. I., 337
Tchernof, A., 35
Terova, G., 117
Thomas, R. M., 183
Tolan, D. R., 321
Tong, L., 265
Vacano, G., 173
Vance, A. M., 251
Vanharanta, S., 59
Vaught, T. D., 251
Viswakarma, N., 291
Voevodski, K., 321
Vohl, M.-C., 35
Wang, D., 47
Weghorst, C. M., 207
Weiner, L. P., 23
Wu, L.-C., 83
Xiao, H. Q., 229
Yamamoto, F., 217
Yamamoto, M., 217
Ye, S. Q., 229
Yerkes, L., 321
Ylisaukko-Oja, S. K., 59
Yu, J., 173
Yu, S., 291
Zhang, H., 1
Zhang, L. Q., 229
Zhang, Y., 173
Zhang, Y., 35
Zhao, Y., 149
Zhong, J. F., 23
Zhou, S., 149
|ade6-704, 71
Adipose tissue, 35
Alternative exon, 59
Alternative splicing, 47
Antidepressants, 183
Apoptosis, 101
Aquaculture, 117
Atherogenic diet, 149
Bioinformatics, 321
BMP signaling, 307
Brain-derived neurotrophic factor, 241
BrdU, 183
Breast cancer, 173, 217
Carbon and nitrogen assimilation, 279
cDNA library, 117
Cell culture, 265
Cell cycle, 345
Cell differentiation, 23
Cholesterol biosynthesis, 345
Chromosomal scanning, 217
Chromosome 8p, 217
Complement C3, 117
Constitutive androstane receptor, 291
Coronary artery endothelial cells, 229
c-Rel, 195
Cyanobacteria, 279
Dentate gyrus, 183
Dexamethasone, 291
Differentiation, 101
DNA methylation, 173, 251
DNA methyltransferases, 251
DNA microarray hybridization, 217
Dynein light chain, 159
Dystrophin glycoprotein complex, 47
Endometrial cancer, 361
Enhancer, 1
Epigenetics, 251
Expressed sequence tab (EST), 321
Expression array, 361
Expression downregulation, 207
Fetal alcohol syndrome, 159
Fumarate hydratase (FH), 59
GAL4 reporter assay, 195
Gene expression, 13, 101, 217, 229, 251, 265, 279
Gene regulation, 83
Genetic alterations, 207
Glucocorticoid receptor, 291
Glucocorticoids, 337
hASCs, 307
Heat shock, 59
Hepatic steatosis, 291
Hepatocyte nuclear factor 4-α (HNF4-α), 337
Hepcidin, 117
Hereditary leiomyomatosis and renal cell cancer (HLRCC), 59
Hippocampus, 183
Homologous recombination, 47
Human, 265
Hypoxia, 59
In-gel assay, 13
Inorganic pyrophosphatase, 13
Insig-SREBP pathway, 149
Isoform diversity, 47
Kidney, 337
K-ras, 101
La motif, 71
LC8-type 1 (DYNLL1), 159
Lipid homeostasis, 345
Liver, 337
|Marine biotechnology, 117
Mdm2, 71
Mediator complex subunit 1 (MED1), 291
Metabolic regulation, 279
Microarray analysis, 23
Microarray(s), 35, 149, 229, 265, 345
Migration, 159
Nerve growth factor, 241
Neural plate, 241
Neural stem cells, 159
Neural tube, 241
Neuroglia, 23
Neuromuscular junction, 47
Neuronal differentiation, 307
Neurotrophin, 241
Neurulation, 241
NF-κB, 195
Northern blot, 321
Nuclear receptor, 1
Obese men, 35
Ocular surface disease, 265
Omental, 35
p16, 207
p75, 241
Paxillin, 159
Pheochromocytomas, 207
Phosphorylation, 195
Platelet-derived growth factor, 1
Pluripotent stem cells, 23
Protein kinase A., 71
Protein–DNA interaction, 13
Quantitative PCR, 321
Real-time qRT-PCR, 217
Regulation of gene expression, 23
Retinoic acid response element, 1
RhoA, 159
Rhombomere, 241
RNA polymerase I, 131
Rrn3, 131
|Shh signaling, 307
Signal transduction, 83
Simvastatin, 229
siRNA, 251
Statin, 149
Stem cell, 101
Stomach, 337
Stress, 59, 183
Subcutaneous, 35
Survival, 361
Systematic Multiplex RT-PCR (SM RT-PCR), 217
T-cell development, 83
Transactivation, 195
Transcription, 1, 83
Transcription initiation, 131
Transcription start site, 13
Transcriptome analysis, 117
Transcriptomics, 321
Tricarboxylic acid cycle (TCAC), 59
Trk, 241
tRNA-mediated suppression, 71
tRNA processing, 71
Tumor suppressor gene, 173
Zinc finger proteins, 83
|Abu-Abab, M. S., 321
Ahmed, M. R., 255
Allegri, L., 59
Amati, F., 339
Angelini, C., 339
Barton, M., 271
Camussi, G., 59
Dai, H., 97
Emma, F., 59
Fardin, P., 155
Gambardella, S., 339
Hamano, A., 27
|Ito, F., 27
Jarzab, M., 191
Jason, T. L. H., 227
Jazowiecka-Rakus, J., 191
Jennen, D., 283
Jia, D., 241
Jia, Y., 255
Kameoka, Y., 67
Lai, J.-M., 15
Mancinelli, E., 339
Nasef, A., 217
Ogita, K., 27
Pablo, J., 205
Qi, C., 255
|Ramchandran, R., 321
Rao, M. S., 255
Reddy, J. K., 255
Reese, B. E., 41
Rinaldi, F., 339
Ruo, C., 141
Sallustio, F., 155
Tang, H., 141
Usuda, N., 255
Vallo, L., 339
Whitney, E. M., 85
Yang, J.-S., 107
Zhang, M., 141
Subject Index
|Adrenal chromaffin cell, 133
Alternative splice variant, 141
Alternative splicing, 73
Alzheimer's disease, 311
Antisense oligodeoxynucleotides, 227
Apoptosis, 73, 141
Aquaporin-1 (AQP1), 329
Arg499Cys, 67
Aurora-A, 15
Aurora-B, 15
Aurora-C, 15
Aurora family, 15
Axon guidance, 321
Big brain (BIB), 329
Dbl oncogene, 155
Early responsive gene, 179
|Fetus, 283
Fibrosis, 107
Focal segmental glomerulosclerosis, 59
Gene expression, 155, 271, 299
H3K4 trimethylation, 271
Inhibition by rare codons, 97
Junction proteins, 311
Major intrinsic protein (MIP), 329
Necroinflammatory, 107
Oligonucleotide microarrays, 191
|Pancreas, 241
Parkinson's disease, 205
Pathogenesis, 339
Phenotypes, 299
Phox2b mutant, 133
PKCd, 73
Podocin, 59
Postmortem, 205
Posttranscriptional regulation, 167
PPARa, 255
Pregnancy, 283
Preimplantation embryo, 283
Prion protein gene (PRNP), 283
Prion, 283
Prostate cancer, 1
Protein trafficking, 27
Proteinuria, 59
Quantitative RT-PCR, 15, 107
T cells, 217
unc5b, 321
Variable antigens, 167
Zebrafish, 321
|Abril, N., 165
Adlard, P. A., 107
Allcock, R. J. N., 1
Amati, F., 39
Anderson, A. J., 107
Bachetti, T., 137
Calleja, C., 177
D'Adamo, M., 39
Eisenhardt, A., 69
Fan, J., 49
Galbán, C. J., 49
|Hakamata, Y., 305
Hartmann, O., 245
Hauner, H., 69
Hoagland, E. M., 231
Inakagi, T., 305
Jbilo, O., 13
Kamath, S. G., 123
Laine, B., 83
Malarkey, W. B., 273
Nardone, A., 39
Ookawara, S., 305
|Pattou, F., 83
Paule, M. R., 259
Peleraux, A., 13
Pennypacker, K. R., 61
Perreau, V. M., 107
Pineau, T., 177
Porter, I., 289
Price, P., 1
Prieto-Álamo, M.-J., 165
Pueyo, C., 165
Quélo, I., 151
Ravazzolo, R., 137
Sanchez-Ramos, J., 123
Takeuchi, K., 305
Vandewalle, B., 83
Wache, S. C., 231
Yeh, P.-E., 273
Zeigler, G., 231
Subject Index
|aNAC, 151
Apoptosis, 13
Aryl hydrocarbon receptor, 231
Autonomic nervous system development, 137
Basic helix-loop-helix, 289
CAG promoter, 305
Data analysis, 223
EC cells, 193
F9-differentiated cells, 193
Gene, 273
|HepG2 cells, 29
Homeobox genes, 137
Human fibroblasts, 29
Human purified beta cell, 83
Huntington's disease, 213
3-Hydroxy 3-methylgultaryl-CoA reductase, 29
lacZ, 305
Mandibuloacral dysplasia, 39
Neuromuscular junction, 289
Oxidative stress, 165
Parkinson's disease, 315
QTL mapping, 223
Quantification, 69
Quantitative RT-PCR, 165
Rat, 107
Signal transduction, 69
Testosterone, 305
Vitamin D, 177
Wound healing, 273
Author Index
|Ai, R., 35
Alejo Blanco, A. R., 1
Alioto, T., 263
Bagchi, D., 251
Cabrera-Luque, J.-M., 23
Dangond, F., 13
Ferrini, J.-B., 125
Galiegue, S., 125
|Harbison, R., 211
Heimberg, H., 141
Heller, R. S., 141
Hoogendoorn, B., 233
Horvat, S., 1
Hunter, J. M., 221
Iglesias, A. H., 13
Jbilo, O., 125
Kalinichenko, V. V., 149
Labhart, P., 35
Madsen, O. D., 141
Nakagawa, Y., 77
O'Donovan, M. C., 233
|Peleraux, A., 125
Persad, A. S., 263
Phillips, C., 251
Prieto-Àlamo, M.-J., 23
Pueyo, C., 23
Ravazzolo, R., 95
Sakamoto, H., 77
Takai, D., 199
Ueda, K., 117, 263, 271
Vengellur, A., 181
Wang, X., 149
Yamamoto, F., 199
Zhou, Y., 149
Subject Index
|Absolute real-time PCR, 23
Actin, 241
Adaptive response, 85
b2-Adrenergic receptor, 105
Adult tissues, 199
Alternative splicing, 13
Alzheimer's disease, 263
Anticancer drugs, 125
Apoptosis, 163
C/EBP-beta, 95
Debrisoquine hydroxylase, 117
Enhancer, 95
Fibroblast, 181
Galactosyltransferase, 233
|Hamster fibroblasts, 85
Hepatitis C, 233
Hepatocytes, 55
Herbal, 251
Hierarchical clustering algorithm, 199
HIF1 protein, 181
Histone deacetylase, 13
Homeobox genes, 199
Hox genes, 199
Human, 141
Human parainfluenza virus type 3, 241
Hydrogen peroxide, 85
Hypertrophy, 149
Hypoxia, 181
Leptin, 251
Malignant glioma cell lines, 35
|Obesity, 251
Osteopontin, 95
Oxidative stress, 1, 23, 85, 211
Pancreas, 141
Rat, 251
Septin 3, 263
Three-dimensional cultures, 55
Ubiquitin, 163
Whole-mount in situ hybridization, 1
Author Index
|Banerjee, A. K., 93, 193
Banerjee, S., 115
Bhattacharya, R., 243
Bhattacharyya, N., 115
Brumfield, L., 165
Casellas, P., 213
Dai, F., 231
Fillmore, R. A., 201
Galiègue, S., 213
He, H., 231
|Intine, R. V., 41
Jbilo, O., 213
Kelley, K., 271
Lim, H., 165
Malur, A. G., 93
Pasinetti, G. M., 271
Qing, W., 271
Reddy, J. K., 165
|Salmon, S. L., 101
Sarkar, S. A., 125
Schools, G. P., 101
Schultz, M. C., 263
Sharma, R. P., 125
She, X., 231
Silve, S., 213
Singh, R., 79
Sinha, K., 243
Spitz, D. R., 179
St-Arnaud, R., 255
Suzuki, T., 179
Teplow, D., 271
Ullu, E., 3
Wang, L., 115
Xiang, Z., 271
Yeldandi, A. V., 165
Zemsky, J., 109
|aNAC, 255
3´ Adenylation, 59
Acyl-CoA oxidase, 165
Alternative splicing, 79
Alzheimer's disease, 271
Amyloid, 271
Androgen receptor, 201
Antiproliferative, 213
Archaea, 17
Autoantigen, 41
bHLH, 279
Cajal body, 17
Developmental gene regulation, 201
E. coli protein synthesis, 109
Gap-filling synthesis, 115
Hamster fibroblasts, 101
Hepatic cells, 153
Homologous gene clusters, 137
Human parainfluenza virus type 3 (HPIV3), 93
Human tumor cell lines, 115
Hydrogen peroxide, 101, 179
In vitro transcription, 93
La protein, 243
Mad, 125
Neural crest, 279
Oxidative stress, 101, 179
P protein, 193
Readthrough of UGA codons, 109
Recoding, 109
Retinoic acid, 125
Ribosome, 17
Ribozyme, 17
RNA binding proteins, 79
RNA-dependent RNA polymerase, 93
RNA modification, 17, 41
RNA polymersae III transcription, 3
RNA processing, 17
RNA recognition motif (RRM), 41
RNA transport, 17
RNase P, 41
Segmentation, 295
Telomerase, 17
3´Uridylation, 59
Vesicular stomatitis virus, 193
Walker A motif, 41
Author Index
|Abasolo, I., 183
Allaman-Pillet, N., 93
Amendt, B. A., 265
Anderson, L. M., 157
Angerer, L. M., 283
Angerer, R. C., 283
Annunziato, A. T., 37
Bailleul-Winslett, P. A., 145
Cai, X., 183
Dadras, S. S., 173, 183
Egly, J.-M., 3
|Gao, J., 115
Ghoshal, K., 203
Goldman, E., 257
Gottsfeld, J. M., 77
Green, P. D., 265
Gronostajski, R. M., 203
Hansen, J. C., 37
Jacob, S. T., 203
Kenny, A. P., 283
Latruffe, N., 291
Major, M. L., 217
Newnam, G. P., 145
Orrenius, S., 195
Perumal, K., 133
|Ramljak, D., 157
Rao, M. S., 173. 291
Reddy, J. K., 173, 291
Reddy, R., 133
Reichel, R. R., 237
Riedl, T., 3
Russo, A. F., 265
Samali, A., 195
Tan, Y., 237
Um, M., 123
Van Orden, K., 29
Wang, Z., 173, 183
Yeldandi, A. V., 173, 291
Zhou, H., 217
Subject Index
|Acetylation, 37
Actin, 145
Activation domain, 123
Androgen-response genes, 183
Apoptosis, 195
Assembly, 37
Astrocytes, 217
5-aza 2´deoxycytidine, 63
Breast cancer, 157
Caspase, 195
Dihydrotestosterone, 183
Endogenous gene expression, 103
Fatty acyl-CoA oxidase, 173
Gene expression data, 249
|Hepatocyte nuclear factor 3, 237
Histone, 37
Histone deacetylase, 63
Hsp27, 195
Human parainfluenza virus type 3 (HPIV3), 115
Inflammation, 115
Liver, 291
Mammalian cells, 133
Neuronal migration, 217
p16INK4, 63
5a-Reductase, 183
Reeler mice, 217
Release factor, 145
Retinoic acid stimulation, 237
Rett syndrome, 63
RNA polymerase pause sites, 257
RNA translation, 133
Sodium azide, 145
T7 expression systems, 257
Wilms tumor suppressor gene, 103
X inactivation, 93
Yeast, 249
Author Index
|Ait-Si-Ali, S., 33
Almasan, A., 197
Andrew, S. D., 311
Attal, J., 299
Bache, A., 151
Cao, W.-Q., 231
Depping, R., 187
Elliott, W. M., 287
Fang, J., 129, 327
Gagandeep, S., 175
|Hall, K., 151
Harel-Bellan, A., 33
Harvey, B., 141
Hayashi, S., 287
Higashimoto, Y., 287
Hogg, J. C., 287
Houdebine, L. M., 299
Hyland, V. J., 311
Jain, S., 231
Kallen, R. G., 85
Learoyd, D. L., 311
Ma, Q., 175
Nakashima, R., 341
Ossenbühl, F., 165
|Perdew, G. H., 273
Pettersson, S., 115
Pospelov, V. A., 19
Pospelova, T. V., 19
Pritchard, L. L., 33
Puissant, C., 299
Pützer, B. M., 1
Rao, M. S., 231
Saifuddin, M., 67
Taubman, M. B., 59
Usuda, N., 231
Van Der Eb, A. J., 19
Wang, Y., 207
Yeldandi, A. V., 231
Zhang, H., 85
Subject Index
|a-Amanitin sensitivity, 165
a1(I) collagen, 151
Activator protein-1, 67
Adenovirus E1A, 287
ADP-ribosyltransferase, 187
AFT-2/c-jun, 115
Alt, 187
Alternative splicing, 311
Antibody staining, 59
Antisense cDNA, 129
AP-1 transcription factors, 19
Ary hydrocarbon receptor (AhR), 273
B cell development, 219
cDNA transfection, 327
Dexamethasone, 311
E1A and cHa-ras oncogenes, 19
fos and jun expression, 19
|gadd45, 197
Gene expression, 175, 311
GPI-anchored protein, 263
Green fluorescent protein, 151
Hepatitis B virus, 175
ICAM-1 promoter, 287
7S K promoter, 105
L6 myotubes, 85
Malignant conversion, 129
Nerve growth factor (NGF), 33
Overexpression, 187
|p21/waf1, 197
p300, 1
Paramecium, 263
Phage T4, 187
Polymerase III, 105
Preproparathyroid hormone, 141
Progenitor B cells, 219
Programmed cell death or apoptosis, 219
Promoter, 67, 115
Protein-protein interaction, 43
Protein purification, 187
RET proto-oncogene, 311
Schizosaccharomyces pombe, 165
T7 promoter, 141
Uterus, 151
Variable surface antigen, 263
Author Index
|Allaman-Pillet, N., 61
Allen, A. E., 321
Ammerer, G., 247
Amundson, S. A., 387
Baron, M. H., 25
Carlson, T., 283
del Monte, F., 337
Edelmann, L., 133
Force, T., 337
Gaynor, R. B., 233
|Hai, T., 321
Hajjar, R., 337
Hanson, E. S., 367
Hardmeyer, A., 149
Hickey, E., 349
Hogenesch, J. B., 205
Holbrook, N. J., 377
Jacob, S. T., 301
Kahn, A., 103
Latchman, D. S., 311
Marsee, D. K., 321
Nikodem, V. M., 1
|Peterson, D. O., 75, 191
Raymondjean, M., 103
Schneider, R. J., 357
Thiele, D. J., 271
Wang, X., 377
Xiao, Q., 1
Young, R., 39
Zimmer, W. E., 115
Subject Index
|N-Acetyltransferase, 13
Actin, 255
Alternative splicing, 1
Androgens, 13
Apoptosis, 377
ATPA gene, 163
ATP-mediated activation, 75
ATP synthase, 163
AU-rich element, 357
Bacteriophage lysis, 39
Calcium-induced stabilization, 357
Developmental gene regulation, 115
E-box, 87
Gcn5/Ada complex, 293
|Heart failure, 337
Heat shock, 261, 271, 283
Heat shock protein(s), 311, 349
Helix-loop-helix, 87
Helix-loop-helix protein, 25
Hematopoiesis, 87
Histone genes, 133
Holin, 39
Hormone response element, 13
HSF(s), 261, 271, 283
Hsp, 271
HSPs, 261
Hypoxia inducible factor, 205
In vitro transcription, 191
Leukemogenesis, 87
NF-k B, 233
Open transcription complexes, 75
p38, 217
|Rac, 255
Reactive nitrogen species, 367
Reactive oxygen species, 255, 367
Restraint stress, 301
Review, 255
RNA polymerase II, 75
Saccharomyces cerevisiae, 283
Unfolded protein response, 293
Waf1, 377
X inactivation, 61
Yeast, 247
|Angerer, N. D., 373
Aros, M. C., 139
Banerjee, A. K., 275
Calandra, C., 185
Daegelen, D., 1
Englander, E. W., 151
Freedberg, I. M., 361
Garson, K., 209
|Hall, K., 35
Hao, H., 231
Hautefeuille, A., 333
Hogenesch, J. B., 287
Hörtnagel, K., 113
Howard, B. H., 151
Hsu, L. C., 87
Humphrey, G. W., 151
Jain, S., 287
Kahn, A., 1
Laudet, V., 333
Ma, S., 361
Norton, P. A., 139
Omori, M., 15
Pagel, F. T., 101
|Qi, C., 185
Qian, X., 23
Qu, S., 349
Rao, L., 361
Samadani, U., 23
Thorgeirsson, S. S., 15
Urso, O., 59
Vigneron, M., 315
Walfish, P. G., 169
Yang, Y.-F., 169
Zhu, Y., 185
Subject Index
|Acceptor stem mutation, 101
Adenovirus, 151
Aldolase A gene, 1
Alternative mRNA splicing, 139
Alu repetitive sequence, 151
Angiotensin-converting enzyme, 73
Autoradiography, 315
Avian DP genes, 259
Basic region, 373
7C2 monoclonal antibody, 315
Development, 349
E2F transcription factor(s), 45, 259
Fast-muscle-specific enhancer, 1
|H5 monoclonal antibody, 315
HeLa cells, 315
Hemoglobin switching, 129
Hepatocyte nuclear factor 3, 23
Hepatocyte-specific gene transcription, 23
Hypoxia inducible factor 1a, 287
Immunoglobulin k enhancers, 113
Keratins, 361
lacZ staining, 301
Matrix metalloproteinase (MMP), 197
NF-kB, 361
Oncogene, 333
P19 EC cells, 35
|Rabbit, 73
Retinoic acid, 35
Retinoid X nuclear receptors, 169
RNA binding, 241
5S RNA genes, 389
RNA polymerase II, 315
Shared regulatory sequences, 1
TATA box, 113
U6 snRNA, 59
Vesicular stomatitis virus, 275
Winged helix, 23
Yeast mRNA processing, 241
Author Index
|Alexandre, Y., 315
Avadhani, N. G., 93
Basu, A., 93
Carter, R. S., 93
Daviet, L., 217
Emiliani, S., 245
Gatignol, A., 217
|Hauschka, S. D., 19
Hawkes, S., 19
Hoeppner, M. A., 133
Ilan, Joseph, 113
Jackson, P., 19
Kahn, A., 315
Laskov, R., 285
Miquerol, L., 315
Oliver, N., 269
Pan, J., 123
|Ranu, R. S., 143
Rao, M. S., 123
Rau, H. A., 71
Reddy, J. K., 123
Reddy, S. K., 123
Reed, M., 19
Reich, N. C., 1
Scholthof, H., 143
Thiesen, H.-J., 229
Usuda, N., 123
Van Lint, C., 245
Walfish, P. G., 255
Ye, R. D., 205
Subject Index
|Acetylation, 245
Activalor domains, 229
Adenoviral RNAs, 79
Adenovirus Iype 5, 79
Antisense DNA, 113
Cell extraction, 79
DEAH proteins, 301
est motif, 93
F0F1 ATP synthase, 181
GABP factor, 93
Histone, 245
|In vitro translation, 143
Initiation, 193
Interchromatin granules, 79
Interferons, 1
Krüppel-type zinc finger genes, 229
L-type pyruvate kinase gene, 315
Mitochondria, 181
Negative regulation, 285
Orphan receptor, 169
p53, 19
Receptors, 205
|Saccharomyces cerevisiae, 301
Signal transduction, 1
Silencer, 285
Small nuclear RNAs, 301
Spliceosome, 301
Target genes, 169
Urate oxidase, 123
Wound healing, 269
Yeast, 71, 331
Xenopsus laevis, 155
Publishing Information
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Disclaimer: Although every effort is made by the publisher and editorial board to see that no inaccurate or misleading data, opinion, or statement appears in this journal, they wish to make it clear that the data and opinions appearing in the articles andadvertisements herein are the sole responsibility of the contributor or advertiser concerned. Accordingly, the publisher, editors, editorial board, and their respective employees, officers, and agents accept no responsibility or liability whatsoever for theconsequences of any such inaccurate or misleading data, opinions, or statements, or with regard to any reported rankings of the journal from year to year.
Drug and Dosage Selection: The authors have made every effort to ensure the accuracy of the information herein, particularly with regard to drug selection and dose. However, appropriate information sources should be consulted, especially for new orunfamiliar drugs or procedures. It is the responsibility of every practitioner to evaluate the appropriateness of a particular opinion in the context of actual clinical situations and with due consideration to new developments.
Copyright © 2018 Cognizant, LLC
Printed in the USA.
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The Journal of Liver Research
Researchers report on promising liver cell transplantation technologies - (September 28, 2018)
The Journal of Liver Research
Drinking coffee may help prevent advanced liver fibrosis
Researcher concludes that 2-4 cups of drip coffee daily can help patients with liver fibrosis slow progression to cirrhosis
Putnam Valley, NY (December 15, 2017) – A researcher who reviewed a number of studies investigating coffee consumption and changes in liver enzymes, liver fibrosis and liver cancer in patients with a variety of liver diseases, has concluded that coffee can serve as an antifibrotic agent in the liver. Patients with chronic liver disease could lower their risk of progressing to advanced liver fibrosis by drinking two to four cups of coffee daily. Only drip coffee provided this benefit.
The paper appears in the current issue of Gene Expression: The Journal of Liver Research and is currently freely available on-line as an unedited, early epub at: http://www.ingentaconnect.com/content/cog/ge
"Coffee is the world's most widely used drug and favored stimulant," said study author Jonathan A. Dranoff, MD, of the University of Arkansas for Medical Sciences. "But only recently have studies in animal models provided evidence that coffee can be an antifibrotic agent in the liver."
Dranoff, who reviewed a number of retrospective studies, cited a 2001 study published in the Annals of Epidemiology (2001;11:458-465) that found a single cup of coffee daily lowered the risk for cirrhosis in patients with chronic liver disease to an odds ratio of 0.47. Four cups of coffee lowered the odds ratio to 0.16.
"The benefit appears to be dose-related," explained Dranoff. "Interestingly, only coffee made by the drip method offers this benefit. Neither Turkish coffee, made by boiling ground coffee beans, nor espresso, made by pressurize hot water, offer this benefit."
Other caffeine-containing products have not had the same antifibrotic effect, he noted.
What mechanism allows coffee to play an antifibrotic effect? Many reports suggest that adenosine, a chemical that is present in all human cells, may play an important role because caffeine is a known antagonist for adenosine receptors, especially for the adenosine A2a receptor. Liver myofibroblasts express the A2a receptor, said Dranoff, and recent research using animal models of cirrhosis has shown that the direct and indirect markers of liver fibrosis were blocked by caffeine, but not blocked by decaffeinated coffee.
The benefit of coffee in reducing the risk of liver fibrosis appears to be dose-related. In studies, rats were greatly "over dosed" on caffeine to have the effect observed, but the benefit for humans may be realized by drinking two to four cups of drip-made coffee daily, preferably not loaded down with sweeteners.
"There is insufficient evidence that more than four cups of coffee per day would further the benefit," suggested Dranoff, who also cautions about emerging data that suggests that coffee has been associated with "all-cause mortality."
"I propose that two to four cups of coffee should be prescribed to patients with chronic liver disease," said Dranoff, who suggested patients not drink too much coffee to the point where they feel anxious or "jittery" or lose sleep. "In my practice I ensure that patients stop consuming other caffeine-containing beverages, from coffee-based milkshake-like products, to sodas with caffeine, and "energy drinks" high in caffeine."
News release by Florida Science Communications www.sciencescribe.net
The Journal of Liver Research
Mechanisms of acetaminophen toxicity unraveled
Hoping to provide a wider window for treatment, researchers add new insight to acute liver failure caused by overdose of commonly used pain reliever, acetaminophen.
Putnam Valley, NY (December 12, 2017) – In the U.S. and around the world, the most common cause of acute liver failure is acetaminophen (APAP) over dose. This commonly used pain reliever is safe and effective when used at recommended doses, but if taken at toxic levels, either by accident or purposefully, acetaminophen overdose lead to liver cell damage, acute liver failure, and death.
A significant public health problem, APAP hepatotoxicity accounts for about half of all acetaminophen-related acute liver failure cases and contributes to around 70,000 hospitalizations in the U.S. every year. APAP overdose is responsible for 46 percent of all cases of acute liver failure in the U.S.
In an effort to better understand the mechanisms of APAP toxicity, and to apply that increased understanding to provide better interventions than currently available, researchers at the University of Kansas Medical Center (UKMC) studied a broad range of cellular toxicity mechanisms that could lead to APAP-induced acute liver failure and liver cell (hepatocyte) death.
The authors note that decades of investigations into the mechanisms of APAP-induced liver injury "have provided significant insight into the role of APAP metabolism" into the cascade of events that can lead to liver injury. However, more insight is needed.
"Although acetaminophen is safe and effective when taken at therapeutic doses, the therapeutic window for treating acetaminophen overdoses is quite narrow and an APAP overdose is highly toxic to the liver." said Dr. Hartmut Jaeschke of the Department of Pharmacology, Toxicology and Therapeutics at UKMC. "Our research is aimed at gaining a better understanding the mechanisms involved in APAP-induced liver injury so that more effective therapeutic interventions can be developed."
According to Dr. Jaeschhke and co-researcher Dr. Anup Ramachandran, also of the UKMC Department of Pharmacology, Toxicology and Therapeutics, when consumed at therapeutic doses, the majority of APAP is excreted through the kidneys. However, after an overdose of APAP the body's metabolic pathways are saturated and a variety of subsequent reactions lead the body form "APAP-protein adducts." Adducts are products of a direct addition of two or more distinct molecules, resulting in a single "reaction product" containing all atoms of the components.
The initial oxidative stress caused by APAP-protein adducts occurs in the cells' mitochondria, the site of cellular energy generation. According to the researchers, mitochondria can also play significant roles in cellular signaling and mitochondrial stress has emerged as a key factor in the cell signaling mechanism involved in APAP-induced liver cell death. This stress, however, has cellular ramifications, including mitochondrial failure.
"A better understanding of APAP-protein adduct formation and their relationship to liver cell death is very important," explained Ramachandran. "Their formation on mitochondrial proteins is most relevant for understanding how APAP toxicity can lead to hepatocyte death."
With APAP toxicity and mitochondrial APAP-protein adduct formation comes oxidative stress and the induction of "mitochondrial permeability transition pore" (MPTP), which ultimately compromises the mitochondrial membrane and shuts down mitochondrial function. Thus, MPTP is central to understanding APAP-induced liver injury, said the authors, who also note that it is now evident that the mitochondrial organelle also plays a significant role in the recovery and regeneration process after toxic injury.
On the positive side, the formation of APAP-protein adducts and their release into the circulatory system might be useful "biomarkers" for diagnosing APAP overdose. Too, they suggested that APAP overdose is a "clinically relevant model" for studying other causes of liver cell death and livery injury and is a model that can be used to study and test potential therapeutic intervention strategies.
What does their work mean for improving clinical interventions to save the lives of those with acute liver failure due to APAP toxicity?
"It is critical to connect these newly-discovered mediators and pathways of APAP metabolism to the already established mechanisms," concluded the authors. "Although more can be learned about various aspects of these mechanisms, it is important to keep in mind potential effects of intervention strategies on drug metabolism, which can lead to misinterpretations. The relevance of these studies will, therefore, depend on the solid understanding of the various toxicity mechanisms."
Their paper appears in the current issue of Gene Expression: The Journal of Liver Research. It is freely available on-line as an unedited, early epub at: http://www.ingentaconnect.com/content/cog/ge/
Funding: Work in the authors' laboratory was supported by the National Institutes of Health grants R01 DK070195 and R01 AA12916, and by grants from the National Institute of General Medical Sciences (P20 GM103549 and P30 GM118247) of the National Institutes of Health. The authors declare no conflicts of interest.
Contact: Hartmut Jaeschke, PhD, Department of Pharmacology, Toxicology & Therapeutics, University of Kansas medical center, 3901 Rainbow Blvd. MS 1018, Kansas City, Kansas 66160, USA.
Tel: 913-588-7969
Fax: 913-588-7501
News release by Florida Science Communications www.sciencescribe.net
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Here's your chance to share a photo of your favorite tractor.
Written By Larry Gay
In its 1961 annual report, Massey-Ferguson stated it had moved from seventh to third place in U.S. farm equipment sales during the last five years. By 1965, Massey-Ferguson continued to remain in third place in U.S. farm equipment sales and had decided its weakness was in the Corn Belt where 40 percent of all U.S. sales were made. First the company purchased a vacant factory in Des Moines, Iowa, and moved its U.S. headquarters and some implement manufacturing to that location. Then in January 1970, Massey-Ferguson introduced the Massey-Ferguson 1150 tractor as the largest row-crop tractor Massey had ever produced. President John Mitchell stated the company wanted to be Number 1 in tractors in North America, as it was in most other countries in the world, and the 1150 tractor was a step toward accomplishing that goal.
The Massey-Ferguson 1150 tractor was the first row-crop tractor to be powered by a V-8 diesel engine and was rated at 135 PTO horsepower. This was more than the John Deere 4520 row-crop tractor with 120 PTO horsepower or the International 1456 row-crop tractor with 131 PTO horsepower. Since Massey-Ferguson owned Perkins, the power plant for the 1150 was a 510-cubic-inch Perkins V-8 diesel engine. The Multi-Power transmission provided 12-forward speeds with the small Multi-Power lever providing on-the-go shifting between a high and low range. The 3-point hitch was a Category 2 and the independent PTO provided 540- and 1000-rpm speeds. The 18.4-38 rear tires were available as singles or duals.
The flat-deck operator's station was located above the transmission for good visibility, both forward and rearward. Operator comfort was provided with the Air-Luxe seat with air and oil suspension, hydrostatic power steering, a tilt and telescoping steering column, and power brakes. A cab was optional and it could be equipped with air conditioning and a heater. A Saf-T-Frame (ROPS) was also optional and it could be used with the cab, as it would fit inside the cab.
In early 1971, Massey-Ferguson continued moving into the larger horsepower tractor market by introducing the 1500 and 1800 4-wheel-drive tractors with 150 and 180 drawbar horsepower, respectively. Both were powered by Caterpillar V-8 diesel engines.
Larry Gay is the author of four tractor books and the "Machinery Milestones" articles in Heritage Iron magazine. To learn more about this magazine which focuses on the 1960-1985 era, go to heritageiron.com or call 1-866-552-6085.
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