text: Home- Faculty Search- Faculty Directory- Ernie Nolen Colgate Directory FACULTY DETAIL < BACK TO RESULTS Ernie NolenGordon and Dorothy Kline Chair in Chemistry; Professor of Chemistry; Director, Division of Natural Sciences and Mathematics Chemistry , 205 Wynn Hall p email@example.com The world of biological molecules is an architectural wonder. As a chemist, I am interested in constructing molecules that mimic aspects of biology for pharmaceutical development. Bringing undergraduate students along in this creative endeavor is one of the most rewarding aspects of teaching at Colgate. Degree BS, University of North Carolina, 1979; PhD, Oregon State University, 1984 Teaching Experience CHEM 101 and 102: General Chemistry I and II CHEM 263 and 264: Organic Chemistry I and II CHEM 452: Metabolic Chemistry CHEM 461: Organic Reaction Mechanisms CHEM 464: Organic Synthesis CHEM 468: Medicinal Chemistry CORE 158: Molecules That Rock Your World Interests Organic chemistry, glycobiology, NMR, volleyball, and juggling Professional Experience Postdoctoral research associate at University of Pennsylvania (1986) with Amos B. Smith Sabbatical research associate at Université Louis Pasteur (1991) with Jean-Marie Lehn and at the Complex Carbohydrate Research Center with Geert-Jan Boons of the University of Georgia Special volunteer at the National Cancer Institute (1998 and 2006) with Joseph Barchi Special Volunteer at the National Institute of Diabetes and Digestive and Kidney Diseases (2014) with Kenneth Jacobson Distinctions Research grants (PI-only) from NIH-AREA 2017; NSF-MRI 2017; NSF-ARI R2 2010; NIH-AREA 2007; NSF-CCLI 2000; NSF-RUI 1994; ACS-PRF-Type B 2005 and 1993 and Type G 1989; NSF Chemical Instrumentation 1988; the Research Corporation 1987; as well as frequent summer support from Bristol-Myers/Squibb and Pfizer. Publications Taura, J.; Nolen, E. G.; Cabre, G.; Hernando, J.; Squarcialupi, L.; Lopez-Cano, M.; Jacobson, K. A.; Fernandez-Duenas, V.; Ciruela, F. "Remote control of movement disorders using a photoactive adenosine A2A receptor antagonist." J. Controlled Release 2018, 238, 135-142. Nolen, E. G.; Ezeh, V. C.; *Feeney, M. J. "Highly Stereoselective Synthesis of C-Vinyl Pyranosides via a Pd0-mediated Cycloetherification of 1-Acetoxy-2,3-dideoxy-oct-2-enitols" Carbohydrate Res. 2014, 396, 43–47 Nolen, E. G.; *Li, L.; Waynant, K. V. "Synthesis of b-C-GlcNAc Ser from b-C-Glc Ser" J. Org. Chem. 2013, 78, 6798–6801 Nolen, E.G.; Donahue, L.A.; Greaves, R.; Daly, T.A.; Calabrese, D.R. "Synthesis of a- and b-C-Glucopyranosyl Serines from a Common Intermediate," Org. Lett. 2008, 10, 4911-14. Nolen, E.G.; Fedorka, C.J.*; Blicher, B.* "Synthesis of orthogonally protected S,S-2,6-diaminopimelic acid via olefin cross-metathesis," Synthetic Comm. 2006, 36, 1707-1713. Nolen, E. G.; Kurish, A. J.;* Potter, J. M.;* Donahue, L. A.;* Orlando, M. D.* "Stereoselective Synthesis of a-C-Glucosyl Serine and Alanine via a Cross-Metathesis/Cyclization Strategy," Org. Lett. 2005, 7, 3383-3386. Nolen, E. G.; Kurish, A. J.;* Wong, K. A.;* Orlando, M. D.* "Short, stereoselective synthesis of C-glycosyl asparagines via an olefin cross-metathesis," Tetrahedron Letters. 2003, 44, 2449. Nolen, E. G.; Watts, M. M.;* Fowler, D. J.* "Synthesis of C-Linked Glucopyranosyl Serines via a Chiral Glycine Enolate Equivalent," Organic Letters. 2002, 4, 3963-65. Nolen, E. G.; Watts, M. M.;* Fowler, D. J.* "Stereoselective Synthesis of C-Linked Glucopyranosyl Serines," Journal of Undergraduate Chemistry Research. 2002, 2, 63-68. Smith III, A.B.; Nolen, E.G.; Shirai, R.; Blase, F.R.; Ohta, M.; Chida, N.; Hartz, R.A.; Fitch, D.M.; Clark, W.M.; Sprengeler, P.A.; "Tremorgenic Indole Alkaloids. 9. Asymmetric Construction of an Advanced F-G-H-Ring Lactone Precursor for the Synthesis of Penitrem D" J. Org. Chem. 1995, 60, 7837. Nolen, E.G.; Marsh, A.; *Gardinier, K.M.; Lehn, J.-M.; "Janus Molecules: Synthesis of Double-Headed Heterocycles Containing Two Identical Hydrogen Bonding Arrays" Tetrahedron Lett. 1994, 397. Onaka, M.; Shinoda, T.; Izumi, Y.; Nolen, E.G.; "Acidic Clay-Directed Polymerization-Cyclization of Aldehydes and Pyrrole to Porphyrins" Stud. Surf. Sci. Catal. 1994, 90, 85. M. Onaka, T. Shinoda, Y. Izumi, and E.G. Nolen, Porphyrin Synthesis in Clay Nanospaces, Chemistry Lett. 1993, 117. Asterisks indicate undergraduate student co-authors who conducted their research in collaboration with a faculty member at Colgate. Description of Current Research Project Synthesis of Methylene Isosteres of Glycosyl Amino Acids and Glycosyl Phosphates Glycosylation of proteins and lipids is a post-translational modification important for numerous physiological processes (1). These glycoconjugates act in protein folding, altering the physico-chemical properties and activity, and adorn the landscape of the cell surface, influencing cell–cell and cell–matrix interactions. Our attention has been directed toward isosteric mimics, which entail methylene substitution for the anomeric oxygen, the so-called C-linked glycosyl amino acids, C-linked glycosyl phosphonates, and C-linked glycosyl lipids, Figure 1. While such an exchange (CH2 for O) does slightly alter the bond angle, bond lengths, and the dihedral angles, there is ample precedent to suggest the conformational change is not insurmountable for binding (2). The methylene isostere offers a great deal of stability, in that degradation by glycosidases, reaction with glycosyltransferases, acid hydrolysis of the anomeric acetal, and b-elimination from the serine are all prohibited. Our goal is to provide convenient synthetic routes to C-linked glycosyl amino acids and C-linked glycolipids, as well as their biosynthetic precursors. Previous synthetic work on C-linkages has explored a wide variety of C-C bond forming reactions (see suggested reading). Despite the significant effort, many of the synthetic approaches require expensive starting materials, are limited in scope to the preparation of only one anomeric stereochemistry, and lose the isosteric relationship by excessively lengthening the intervening carbon chain. While our work does not remedy all these shortcomings, it does offer complementary approaches to these biologically significant materials and is well-suited for serious undergraduate research. The proposed syntheses are short, are adaptable to a variety of biomimetics, and utilitize chemistry that is well precedented and not experimentally tedious. Synthesis of C-Glycosyl Serines Our previous work in this area involved alkylation of iodides 3 with the enolate derived from Williams' Boc-protected diphenyloxazinone 4, Scheme 1. The iodides originated from a-C-allyl glycosides, which are readily prepared and well-known in the literature. Although this reaction was stereoselective and provided access to the isosteric glycosyl serine 5, and to the b-anomers as well, it was not amenable to acetyl glycosides or N-acetyl precursors (3). A more functional group-tolerant reaction methodology for C-glycosyl amino acid synthesis was utilized in our lab by employing the Grubbs' second generation catalyst (4) for the olefin cross-metathesis (CM) between C-allyl glycoside 6 and vinyl glycines 8-10, prepared from methionine or glutamic acid (5), Scheme 2. A explosion of reports have appeared since the catalyst has become commercially available and these have been recently reviewed (6). This methodology has provided a concise entry into glycosyl amino acids in which the intervening carbon chain contains three or more methylenes. In our hands and in accordance with others, the linking carbon chain between the glycoside and the amino acid cannot be made shorter than three carbons (e.g., serine mimics require only two methylenes) without seriously diminishing the yield, as evidenced by >70% recovered C-vinyl glycoside 7 in all attempted reactions utilizing this cross-metathesis partner and our vinyl glycines 8-10. Students working in my lab have enjoyed recent success, attested to by the five undergraduate co-authors on publications in the past two years. As a mentor, the PI works alongside the students as they gain confidence learning the techniques involved in running reactions, purifying products on our new Isco Flash Chromatography station, and identifying structures. The acquisition of a new 400 MHz NMR has greatly simplified training on how to acquire NMR data, and has focused much more attention on the interpretation of data with students. The recent purchase of an ion-trap GC-MS and the soon to be acquired MALDI-TOF mass spectrometer facilitate molecular weight determination for characterization of products. Jennifer Potter ('04) writing up the results of a reaction in her laboratory notebook. (Spring 2004) Michael Orlando ('04) loading a sample into Colgate's Bruker 400 MHz NMR spectrometer. (Spring 2004) References See the entire issue of Science. 2001, 291(9), 2263-2502. (a) J. Jiménez-Barbero, J.F. Espinosa, J.L. Asensio, F.J. Canada, A. Poveda Adv. Carbohydrate Chem. Biochem. 2001, 56, 235-85. The Conformation of C-Glycosyl Compounds. (b) L.M. Mikkelsen, M.J. Hernaiz, M. Martin-Pastor, T. Skrydstrup, J. Jiménez-Barbero J. Am. Chem. Soc. 2002, 124, 14940-51. Conformation of Glycomimetics in the Free and Protein-Bound State: Structural and Binding Features of the C-glycosyl Analogue of the Core Trisaccharide -D-Man-(1>3)-[-D-Man-(1>6)]-D-Man. E.G. Nolen, M. M. Watts, D.J. Fowler Org. Lett. 2002, 4, 2963-65. Synthesis of C-Linked Glycopyranosyl Serines via a Chiral Glycine Enolate Equivalent. (a) H.E. Blackwell, D.J. O'Leary, A.K. Chatterjee, R.A. Washenfelder, D.A. Bussmann, R.H. Grubbs J. Am. Chem. Soc. 2000, 122, 58-71. New Approaches to Olefin Cross-Metathesis. (b) M. Scholl, S. Ding, C.W. Lee, R.H. Grubbs Org. Lett. 1999, 1, 953-56. Synthesis and Activity of a New Generation of Ruthenium-Based Olefin Metathesis Catalysts Coordinated with 1,3-Dimesityl-4,5-dihydroimidazol-2-ylidene Ligands. E.G. Nolen, A.J. Kurish, K.A. Wong, M.D. Orlando Tetrahedron Lett. 2003, 44, 2449-53. Short, stereoselective synthesis of C-glycosyl asparagines via an olefin cross-metathesis. S.J. Connon, S. Blechert Angew. Chem. Int. Ed. 2003, 42, 1900-23. Recent Developments in Olefin Cross-Metathesis. Suggested Reading The preparation of C-glycosyl amino acids has been reviewed by Dondoni (1). Since that review there have been several reports toward the development of concise and broadly applicable routes to C-glycosyl amino acids, including our own (see publication list), and others utilizing the Ramberg-Bäcklund rearrangement (2), acetylide couplings (3), and an asymmetric Strecker reaction (4) The C-phosphonate analogs have been prepared as mimics for the UDP-glycosides and glycolipids (5) General approaches to form the C-glycosidic bond to phosphonates include anomeric radical additons to unsaturated phosphonates (6), Wittig chemistry with concomitant ring closures (7) elaboration from C-allyl glycosides (8) and phosphonate anion addition to glyconolactones (9) Application of some of these approaches has led to the preparation of some UDP-glycosyl mimics (10), decaprenolphosphoarabinose analogues (11), muramic acid derivatives (12) mannosyl phosphate mimics (13), and a bacterial peptidoglycan analogue (14). Citations most closely related to our work include Dondoni (15) McGarvey (16) and Postema (17): A. Dondoni, A. Marra Chem. Rev. 2000, 100, 4395-4422. Methods for Anomeric Carbon-Linked and Fused Sugar Amino Acid Synthesis: The Gateway to Artificial Glycopeptides. (a) D.E. Paterson, F.K. Griffin, M.-L. Alcaraz, R.J.K. Taylor Eur. J. Org. Chem. 2002, 1323-1336. A Ramberg-Bäcklund Approach to the Synthesis of C-Glycosides, C-Linked Disaccharides, and C-Glycosyl Amino Acids. (b) Y. Ohnishi, Y. Ichikawa Bioorg. & Med. Chem. Lett. 2002, 12, 997-99. Stereoselective synthesis of a C-glycoside analogue of N-Fmoc-serine b-N-acetylglucosamine by Ramberg-Bäcklund rearrangement. (a) Dondoni, A.; Mariotti, G.; Marra, A. J. Org. Chem. 2002, 67, 4475-4486. Synthesis of a b-Glycosyl Asparagine Ethylene Isosteres via Sugar Acetylenes and Garner Aldehyde Coupling. (b) Dondoni, A.; Mariotti, G.; Marra, A.; Massi, A. Synthesis 2001, 2129-2137. Expeditious Synthesis of b-Linked Glycosyl Serine Methylene Isosteres via Ethynylation of Sugar Lactones. S.P. Vincent, A. Schleyer, C.-H. Wong J. Org. Chem. 2000, 65, 4440-4443. Asymmetric Strecker Synthesis of C-Glycopeptide. For a review see F. Nicotra, Synthesis of Glycosyl Phosphate Mimics. In Carbohydrate Mimics; Y. Chapleur, Ed.; Wiley-VCH:Weinheim, 1998, pp 67-85. H.-D. Junker, W.D. Fessner Tetrhedron Lett. 1998, 39, 269-72. Diastereoselective Synthesis of C-Glycosylphosphonates via Free-Radical Glycosylation. R.B. Meyer Jr., T.E. Stone, P.K. Jesthi. J. Med. Chem. 1984, 27, 1095-98. 2,5-Anhydro-1-deoxy-1-phosphono-D-altriol, an Isosteric Analogue of a-D-Ribofurnaose 1-Phosphate. O. Gaurat, J. Xie, J.-M. Valéry. Tetrahedron Lett. 2000, 41, 1187-89. A concise synthesis of C-glycosyl phosphate and phosphonate analogues of N-acetyl-a-D-glucosamine-1-phosphate. (a) F. Orsini, A. Caselli. Tetrahedron Lett. 2002, 43, 7259-61.SmI2-mediated reactions of diethyl iodomethylphosphonate with esters and lactones: a highly stereoselective syntheiss of a precursor of the C-glycosyl analogue of thymidine 5'-b-L-rhamnosyl)diphosphate. (b) A. Dondoni, A. Marra, C. Pasti Tetrahedron: Asymmetry 2000, 11, 305-17. Stereoselective synthesis of C-glycosylphosphonates from their ketols. Reconsideration of an abandoned route. A. Schäfer, J. Thiem. J. Org. Chem. 2000, 65, 24-29. Synthesis of Novel Donor Mimetics of UDP-Gal, UDP-GlcNAc, and UDP-GalNAc as Potential Transferase Inhibitors. C.A. Centrone, T.L. Lowary. J. Org. Chem. 2002, 67, 8862-70. Synthesis and Antituberculosis Activity of C-Phosphonate Analogues of Decaprenolphosphoarabinose, a Key Intermediate in the Biosynthesis of Mycobacterial Arabinogalactan and Lipoarabinomannan. G. Brooks, P.D. Edwards, J.D.I. Hatto, T.C. Smale, R. Southgate. Tetrahedron 1995, 51, 7999-8014. Synthesis of Derivatives of Muramic Acid and C-1 Homologated a-D-Glucose as Potential Inhibitors of Bacterial Transglycosylase. V.S. Borodkin, M.A.J. Ferguson, A.V. Nikolaev. Tetrahedron Lett. 2001, 42, 5305-08. Synthesis of b-D-Galp-(1?4)-a-D-Manp methanephosphonate, a substrate analogue for the elongating a-D-mannosyl phosphate transferase in the Leishmania. (a)L. Qiao, J.C. Vederas. J. Org. Chem. 1993, 58, 3480-82. Synthesis of a C-Phosphonate Disaccharide as a Potential Inhibitor of Peptidoglycan Polymerization of Transglysosylase. (b) Zahra, J.; Hennig, L.; Findeisen, M.; Giesa, S.; Welzel, P.; Muller, D.; Sheldrick, W.S. Tetrahedron 2001, 57, 9437-9452. Synthesis of a building block for phosphonate analogues of moenomycin A(12) from D-tartaric acid. (c) Abu Ajaj, K.; Hennig, L.; Findeisen, M.; Giesa, S.; Muller, D.; Welzel, P. Tetrahedron 2002, 58, 8439-8451. Synthesis of a complex disaccharide precursor of phosphonate analogues of the antibiotic moenomycin A(12). A. Dondoni, P.P. Giovannini, A. Marra. J. Chem. Soc., Perkin Trans. 1, 2001, 2380-88. A concise C-glycosyl amino acid synthesis by alkenyl C-glycoside–vinyloxazolidine cross-metathesis. Synthesis of glycosyl serine, asparagine and hydroxynorvaline isosteres. G.J. McGarvey, T.E. Benedum, F.W. Schmidtmann. Org. Lett. 2002, 4, 3591-94. Development of Co- and Post-Translational Synthethic Strategies to C-Neoglycopeptides. (a) M.H.D. Postema, J.L. Piper. Org. Lett. 2003, 5, 1721-23. Synthesis of Some Biologically Relevant b-C-Glycoconjugates. b) D. Calimente and M.H.D. Postema. J. Org. Chem. 1999, 64, 1770-71. Preparation of C-1 Glycals via Olefin Metathesis. A Convergent and Flexible Approach to C-Glycoside Synthesis. See also: E.A. Voight, C. Rein, S.D. Burke. J. Org. Chem. 2002, 67, 8489-99. Synthesis of Sialic Acids via Desymmetrization by Ring-Closing Metathesis


text:
Are you a better lover if you abstain from masturbation?
A friend of mine is a radio-show host. He recently passed on a link to a clip from another station. "Possible column topic for you," read the subject line. Within the email body, underneath the audio link, the topic: "Are you a better lover if you abstain from masturbation?"
Good question, I thought, as I listened to a man – who may now present a major metro commercial-radio breakfast show – respond to questions from his co-host about his alleged refusal to succumb to Harvey Danger's Flagpole Sitta suggestions for fear his shagging would suffer. And it remains a good question, left largely unanswered by the wireless star concerned as he basically bluffed through the surprise on-air interrogation. Poor chap.
Poor chap – or inspired lover? Perhaps he's really on to something. Perhaps he should be crowing, not blowing off the advances of the why-curious. Perhaps there's merit to this seemingly mad idea that your bedroom performance may be significantly improved were you to avoid any self-inflicted pleasure-making.
"Ridiculous!" Broaching the subject over dinner with friends yields an unequivocally critical response. "I don't think I'd manage proper bonking if I did away with my own personal 'special time' sessions. I think that enhances my own self-awareness, and drives me to seeksucceed similar satisfaction with my partner."
One of my girlfriends, not one to mince words, goes on to explain how masturbation opened up a whole new world of sensual possibility. Before she started wanking, she says, she wasn't aware just how deeply wonderful sex – self-sex or otherwise – could be. She gave herself her first orgasm, and says that if she hadn't she mightn't be so hell–bent on achieving one when time came for plus-one love-making.
"I'd probably just be bored of sex," she says. "If I didn't masturbate, and never discovered my potential, I'd probably just come to a point when sex – even with someone I might love dearly – just became another semi-tedious activity done to keep the peace. It's because I masturbated that I enjoy sex and want to keep on enjoying sex as much as possible."
Fair point, I thought. But masturbating for the sake of sexual self-discovery might be a different sort of stroke to the one our radio bloke was talking about. Maybe he was thinking more along the lines of the boxer who, before the big fight, bans carnal relations with his woman for the sake of storing vital energy. He might have been motivated more by tantric teetotalling, less by absolute avoidance.
"Well, I reckon there's some logic there." Another friend – male – pipes up. "I know that if it's been a while between bingos, I'm more eager to play. I'm also more likely to deliver a show-stopping result when that crucial ball is drawn."
I can relate. Blue-balling might be a male affliction, but I'm sure I'm not the only female who's come to the end of that unavoidable monthly malady and faced a panting sense of urgency for action. Sometimes saying no, even involuntarily, is as powerful as saying yes. But would I pass up personal time and the guaranteed happiness it brings on the off-chance it might make me better in bed? Just how would it make me better, I wonder?
"More attentive maybe," my male mate's girlfriend pipes up. "Maybe because you're keener to ensure an orgasm than you'd otherwise be, and you realised that the best way to do that is by making your partner happy? You're a more considerate lover than you'd otherwise be? And maybe you'd last longer as well?"
In a bid to endavoid the awkward lull her comments may have led to, we changed the subject. Though I still wonder, does she have a point? Is that what the radio host meant when he said putting a hold on deposits at the wank bank corresponded with greater returns? Indeed, I may be overcomplicating the issue. Perhaps his religion prohibits personal satisfaction. Could it be he meant "better" to mean "in the eyes of God"?
The science on the subject is not clear, nor is it definitive. There is evidence to suggest that saying a deliberate "no" to masturbation might make you a better lover in the same way that knowing how to control the heat levels on a cooktop might make you a better cook. Being in command of your body, and your sexuality, can be a good thing. But, of course, that command doesn't necessarily come about through abstinence, and command doesn't necessarily mean saying "no" instead of "yes".
So, over to you. What do you think? Have you tried abstinence for the sake of better sex? Did that abstinence extend to masturbation? Did it work? Why, why not, or why would you not give the "no" a go?
Katherine Feeney is a journalist with the Nine Network Australia.
Katherine Feeney is a journalist with the Nine Network Australia. She is also one of Australia's leading commentators on sex, love, dating and relationships via her popular blog CityKat.

subset: commoncrawl


text:
Fashion Accessory #shotoverjet Take 1
Shotover Jet is preparing to keep your ears and your noses toasty warm this winter when you take a trip on our 'Big Reds' with a Shotover Jet scarf.
We are all about sharing the love at Shotover Jet. As the temperature drops and the winter woolies are dug out from storage, Shotover Jet is preparing to keep your ears and noses toasty warm this winter when you take a trip on our 'Big Reds' with a Shotover Jet scarf. An order of 50,000 have just arrived after a long boat ride ready for when those winter mornings start. Shotover Jet does not stop just becuase the season has changed.
The Shotover Jet scarf is not just a one-wear wonder. It is the fashion accessory that keeps on giving. As we are all about multi-tasking at Shotver Jet, I thought it best to use the talented staff we already have to help create some fashion accessory tips for the Shotover Jet scarves. Having such a talent bunch to choose from, I thought auditions may have been needed but it seems that a few were too camera shy to clip their tickets in the model search. There were many willing to be an audience during rehearsals as they watched their colleagues get tongue twisted and flushed. However, through cleaver team work, thank you to my models Ollie and Tomika, we have complied 12 different ways to wear this very trendy and standout fashipon accessory that reall does need to be added to your wardrobe.
Whether you need something to keep your hair off your face, wipe the sweat from your brow or keep your nose and ears toasty warm, here at Shotover Jet we have your fashion accessory sorted providing some entertaining lessons to help get you started. Wear your Shotover Jet scarf proudly and be a trendsetter.


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"The Tomorrow People," which centres on young people with superpowers with targets on their backs (thanks to an evil government task force), is a month into its run and if you thought it was good now, just wait for the upcoming episodes.
HuffPost TV Canada spoke with series star Robbie Amell and we couldn't have timed it any better. Amell previewed that things are about to get dark for Stephen (the character, not his cousin) in tonight's episode, "All Tomorrow's Parties" -- and it's just the beginning. The actor also spoke about whether he's sick of Amell Wednesdays, working so closely with Nina Myers and Jacob, and a possible "Tomorrow People"/"Arrow" crossover.
HuffPost TV: Every time Stephen gets caught doing something he shouldn't at Ultra, his excuses are so bad! But Jedikiah just keeps letting them slide. He could've had Stephen killed already! Do you think he hasn't because Stephen is family or Jed is just biding his time, waiting for Stephen to make a huge mistake that will lead him to the Tomorrow People?
Robbie Amell: I think it's a little bit of both. He definitely starts to see that Jedikiah is smarter than he's letting on. He's always got the upper hand, and he's really just toying with him, waiting. And also Jedikiah, you find out he doesn't call all the shots. There are people above him, characters who are introduced shortly. And at the same time, he is family. The bond between Stephen and Jedikiah grows over the next few episodes. Stephen definitely makes strides to prove himself to Ultra and I would definitely say his excuses get better [Laughs].
The family dinner [from Episode 4, "Kill or Be Killed"] couldn't have been more awkward.
Yeah, my mom on the show, Marla, played by Sarah Clarke -- she's a smart woman and there are definitely things about her that we don't know that she's hiding from Stephen, she's hiding from the audience and it'll be interesting to see her character unfold. You don't want to mess with Mom.
Stephen wants to try and do everything, and use his powers for the greater good. Will that push/pull with both Ultra and the Tomorrow People continue, him wanting to save everybody? Is that just in his nature?
Yeah, and it's one of my favourite parts about the character. He's torn between these two worlds, and he's also trying to find his dad. He's in a tough position; he can't walk away from Ultra, he can't walk away from the Tomorrow People and he can't walk away from his family, so, really, he's torn between these three lives. You say he can't save everyone, but he can't pick one to give up on. I think it's interesting to see in each episode how I get to these decisions and find ways to protect my family, to protect my other family, the Tomorrow People, and to save face at Ultra while all the while trying to find my dad and have a relationship with him. Everything I've ever known about him turns out to be pretty much a lie, so coming from a guy who has a fantastic relationship with his father, I couldn't imagine what it would be like finding out that everything is a lie and not knowing anything about him. I would be the same way, that would be the priority. I would have to find him.
As far as priorities go, will there ever come a time where Stephen sees John and Cara's side of it, that protecting their species is what he needs to do at all costs?
Things get so dark over Episodes 5 and 6 that Stephen has to step away from Ultra in Episode 7. I can't tell you much more than that, but it gets to the point where the stress and the guilt and everything is weighing on him too much, and he needs to take a break and step away. You really get to see a different side of him, maybe a more human side, and then everything goes to hell [Laughs]. But Episodes 8 and 9, we answer a ton of questions that I think people have asked or have been asking. It's a great two-part episode that leads into the Christmas holiday. Episodes 5 - 9 really start to dive into what I feel like the show is really going to be, hopefully for a long time.
In last week's episode, Astrid witnessed you disappear, but in Episode 4 -- nothing. What can we expect from their friendship now that she knows something is up? And is that all it is? Are they just friends?
You find out a lot of that in Episode 5. Astrid is back in Episode 5. Stephen's trying to reconcile with her. She's his only friend, really, and the problem is, he tried to tell her in the pilot about these powers. She blocked him out and shut him down. And now she's asked him about them and he can't tell her. He's got that superhero syndrome, where the people closest to you ... because then they can be used against you and it puts them in danger. It's just one more ball in the juggling act that Stephen has in Episode 5.
And are they just friends? And will they stay just friends?
As a potential love interest?
Um ... well, there's the Cara love triangle with John, and Astrid is definitely put into that. They're best friends and if the history of television and cinema has taught us anything, the best friend is probably the one he ends up with. But for the next couple episodes, anyway, there's not as much concentrating on the love interest there than it is him getting her back as a friend.
Will we meet Stephen's dad soon -- and not just in flashbacks?
Jeffrey Pierce, who plays Roger, will be back shortly. You start to see more and more of him as the first season progresses and you will see in a flashback. As long as we get a full 22-episode season, you will see him not in a flashback before the midseason mark.
So Stephen is telepathic, can teleport and can use telekinesis. Not that that's not enough, but does he have any other powers?
No, he's got the three Ts and he can stop time. The way he uses these powers, one of them has an interesting story point to it, which I can't share with you, but it's very important in the survival of the Tomorrow People and their species as a whole.
We find out your mom has some secrets. Is there any chance she might have powers? And what about Stephen's brother, Luca?
I've been asking the same questions. Up until this point that we've been shooting, she hasn't shown any powers yet. But, you know, it's a definite possibility. My dad had powers, I have powers, we can definitely end up breaking out. My mom could be hiding them this whole time. These are the same questions I've been asking when I read the scripts. But I can't say no, and I can't say yes, but it's a definite possibility.
Are you sick of talking about Amell Wednesdays?
[Laughs] You know, I'm not. How can I be sick of it? It might be a once-in-a-lifetime thing.
Ever! How often does this happen? Never.
I've never heard of it happening before. And how can I be sick of talking about it? It's impossible that it happened and it just did. It's incredible. We're both leads of television shows on the same network on the same night, back to back. It's completely insane but it's amazing. It's completely surreal and Stephen and I, we both feel very lucky that we're able to share this with each other. The upfronts in New York were incredible, going on stage, introducing Wednesday night, it was a feeling I'll never forget. Shooting a commercial for The CW for Amell Wedensdays ... it's incredible. I'm very, very grateful to the CW and Warner Bros. and everybody that made it happen because it's a dream come true. It's completely insane.
The network has to do some sort of crossover, just to capitalize on it that much more.
[Laughs] Stephen and I have been pitching it. Stephen wants me to come in and I don't even have to say a line. He just wants to have me on the phone getting into a nice car and Stephen as Oliver Queen at Queen Consolidated, looks over and goes, "Hey Bruce," and I just give him a nod and get in the car as if I'm Bruce Wayne [Laughs].
"The Tomorrow People" airs Wednesdays at 7 p.m. EST on CTV in Canada and 9 p.m. EST on The CW in the U.S.
Also on HuffPost


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With the second wild-card berth in the Eastern Conference up for grabs, the Columbus Blue Jackets host the Detroit Red Wings on Tuesday. The former Central Division rivals are even in points, but Columbus currently owns the spot by virtue of having four more victories. The Blue Jackets' chance to move two points ahead of the Red Wings ended quickly as Monday's game in Dallas was postponed after Stars center Rich Peverley collapsed on the bench early in the first period, resulting in the postponement of the contest.
Detroit came up empty at Madison Square Garden on Sunday, dropping a 3-0 decision to the New York Rangers. It was the third setback in four games (1-2-1) for the Red Wings, who continue to be without captain Henrik Zetterberg, star playmaker Pavel Datsyuk and several others due to injuries. Detroit posted a 2-1 win at home on Oct. 15 in the opener of the three-game season series between the clubs.
TV: 7 p.m. ET, FSN Plus (Detroit), FSN Ohio (Columbus)
ABOUT THE RED WINGS (29-22-13): Joakim Andersson became Detroit's fourth center to land on the sideline when he suffered a fractured foot in Sunday's loss. The 25-year-old Swede, who has recorded seven goals and eight assists in 58 games this season, joins Datsyuk, Stephen Weiss and Darren Helm on the shelf. The Red Wings recalled center Cory Emmerton, who notched two assists in 11 contests with Detroit earlier this season, from Grand Rapids of the American Hockey League.
ABOUT THE BLUE JACKETS (33-26-5): Although Columbus held a 1-0 lead over Dallas on Nathan Horton's power-play goal, the club had no problem with the decision to postpone the game. "They're shaken and they want to reschedule. We understand that," president of hockey operations John Davidson told FSN Ohio. "They were shaken to the core." Artem Anisimov was named the NHL's Second Star of the Week on Monday after registering four goals - three game-winners - in four contests.
1. Detroit C David Legwand has recorded a goal and two assists in three games since being acquired from Nashville.
2. Columbus D Nikita Nikitin was back in the lineup two days after missing Saturday's contest with a head injury.
3. G Sergei Bobrovsky is likely to be in net against Detroit, even though G Curtis McElhinney's start was cut short Monday.
PREDICTION: Blue Jackets 3, Red Wings 1


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About the Green Meter
The iLinc Green Meter enables iLinc users to measure the tangible benefits of meeting online rather than in person. By eliminating a trip by air or car, iLinc users prevent carbon emissions from entering the atmosphere and save time that would have been spent traveling.
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hopefully this image can be useful and can be an inspiration for readers.
there are many things about something related to this text and image ,, the image is a curling or valuable artistic value. with pictures or writings can reflect everything.
I hope this site and this paper can provide the desired information and make pemahan for the connoisseurs of the image.
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State-of-the-Art Sonar Map Reveals New Details of Sunken Civil War-era Warship
A new, 3-D state-of-the-art sonar map released January 11 by NOAA's Office of National Marine Sanctuaries, ExploreOcean, Teledyne Blueview, and Northwest Hydro shows never-before-seen details of the USS Hatteras, the only Union warship sunk in combat in the Gulf of Mexico during the Civil War.
One hundred and fifty years ago this month, approximately 20 miles off the coast of Galveston, Texas, the Hatteras, an iron-hulled steamship the U.S. Navy converted into a gunboat, was sunk during a battle with the famous Confederate commerce raider CSS Alabama. The battle was one of the skirmishes that saw the key southern port of Galveston change hands twice and remain one of the last bastions of the Confederacy.
Today, the wreck of the Hatteras is largely intact, resting 57 feet underwater in sand and silt. Recent hurricanes and storms have removed some of the sediment and sand that once encased the vessel like a time capsule. Given shifting sands may once again rebury the Hatteras, the team used a short window of opportunity for a two-day mission last fall to create 3-D photo mosaics of the Hatteras for research, education, and outreach purposes. Read more | Photo gallery


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Features & Highlights
Why you should buy this product
Samsung Galaxy S6 Case, [Black] Slim & Flexible Anti-shock Crystal Silicone Protective TPU Gel Skin Case CoverMost silicone cases are extremely light weight and rubbery; this is where this BLACK crystal silicone TPU case differs. A merge between highly durable hard materials that you find in many electronics packaging and silicone for it's flexibility and slightly opaque sheen. Together these elements give your phone, the best possible protection and grip for your Samsung Galaxy S6 without having you to sacrifice style.
Thermoplastic Polyurethane (TPU) material fuses the flexiblity and softness of silicone with the hard protection of plastic. High quality, slim fit case molds to fit your phone without covering important buttons and ports. Rubberized, matte finish slides easily in and out of pockets without gathering lint and dust. Firm enough to protect from scratches and drops, soft enough to conform to every nook and cranny of your Galaxy S6. Vibrant Black color enhances the look of your phone without making it bulky and burdensome.
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Iran Today: Presidential Election --- Censoring An Iranian Campaign Story
Rouhani On Iran- Qatar Relations
Moderate Presidential candidate Hassan Rouhani congratulated Iran on Tuesday evening on an important victory over its rival Qatar --- dashing the Gulf state's hopes after dominating it.
Iran beat Qatar 1-0 on the football field.
Another step towards #Brazil...congratulations to all #Iranians on #victory against Qatar!! #Iran #WorldCup #Brazil2014— Rouhani Campaign (@HassanRouhani) June 4, 2013
Meanwhile, Iran summoned Qatar's charge d'affaires on Tuesday over what it said was an "Arab-linked terrorist plot".
Ahmadinejad Camp to Maintain Influence in Tehran?
President Ahmadinejad's camp has been blocked at national level from continuing influence, with the disqualification of Ahmadinejad's right-hand man Esfandiar Rahim-Mashai as a candidate, but this may not be the end of the story....
The Ahmadinejad faction has put forth Minister of Transportation and Housing Ali Nikzad as candidat for Tehran mayor, and has named other hopefuls for city council seats, including Ahmadinejad's sister Parvin and Presidential advisor Ali Zabihi.


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Parasoft has announced that the API to its development testing platform is now available publically. Developers are invited to use the API to integrate "any" tool across the software application development lifecycle.
Parasoft's platform features a policy-driven process that integrates static analysis, unit testing, coverage analysis, and peer code review including preparation, notification, and tracking.
The software is also marked out for its runtime error detection across memory leaks, race conditions, exceptions, etc. — plus its traceability across requirements tasks and when examining code defects, code reviews, or tests. This range of capabilities is now extended by integrating any internal, open source, or COTS via the API.
"The opportunity to integrate any tool into this platform gives organizations a single point of control for all activities associated with developing secure, reliable, and compliant code," said Wayne Ariola, VP of Strategy for Parasoft. "This not only enables a much better understanding of what is being developed and how it is being developed — it also assists organizations in broadening the scope of development policies being monitored to ensure that software is being developed in line with management's expectations."


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The Gabelli Gold Fund, Inc. Class AAAPerformance by Year
Fund Performance by Year
As of June 26, 2019
|Maximum Sales Charge(%) (1)
|Gross Expense Ratio (%) (2)
|Net Expense Ratio (%) (3)
(1) Maximum Sales Charge for Class A shares is a percentage of the initial investment and may be
reduced based on the size of your investment. Class B and C shares have a contingent deferred sales charge
when you redeem your shares depending on your holding period. Please see the Fund's Prospectus or contact
your Adviser for a complete description of the applicable sales charge.
(2) Gross Expense Ratio is the expenses of the Fund reflected as a percentage of the Fund's average daily net assets and do not include any voluntary or contractual fee waivers or expense limitations as described in the Fund Prospectus.
(3) Net Expense Ratio is the expenses of the Fund including any voluntary or contractual fee waivers or expense limitations as a percentage of the Fund's average daily net assets. Where applicable, please see the Fund's Prospectus or contact your Adviser for a complete description of the fee waiver or expense limitation, the effective date and the expiration date. Inception Date: July 11, 1994 Returns represent past performance and do not guarantee future results. Current performance may be lower or higher than the performance data quoted. Investment return and principal value will fluctuate so, upon redemption, shares may be worth more or less than their original cost. To obtain the most recent month end performance information and prospectus, please call 800-GABELLI or visit www.gabelli.com
Performance is for the share class noted only. Other share classes may have different performance characteristics. The historical performance of Class AAA Shares is used to calculate performance for Class A and C Shares prior to their issuance on December 27, 2002, and Class I Shares on January 11, 2008. The actual performance for the Class C Shares would have been lower and Class I Shares higher due to the different expenses associated with those classes of shares. Performance for periods of less than one year are not annualized. The Fund imposes a 2% redemption fee on shares sold or exchanged in seven days or less after the date of purchase.
The Fund's share price will fluctuate with changes in the market value of the Fund's portfolio securities. Stocks are subject to market, economic and business risks that cause their prices to fluctuate. When you sell Fund shares, they may be worth less than what you paid for them. Consequently, you can lose money by investing in the Fund.
Investment in gold stocks is considered speculative and is affected by a variety of worldwide economic, financial and political factors. The Fund may be subject to significant volatility and investors may experience substantial loss of value in a short period of time. The Gabelli Gold Fund invests in foreign securities which involves risks not ordinarily associated with investments in domestic issues, including currency fluctuation, economic and political risks. Funds concentrating in specific sectors may experience greater fluctuations in value than funds that are more diversified.
Investors should carefully consider the investment objectives, risks, charges and expenses of the Fund before investing. The prospectus, which contains more complete information about this and other matters, should be read carefully before investing. To obtain a prospectus, please call 800-GABELLI or visit www.gabelli.com.
The Gabelli Mutual Funds are distributed by G.distributors, LLC., a registered broker-dealer and member of FINRA.


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"Festival of the Sea"
Based upon the original by Eugene Savage, 1938-1940
Printed by Lahaina Printsellers, Ltd., 2016
Commissioned by the Matson Navigation Company to create a series of murals in 1938, Eugene Savage completed the task in 1940. Due to the outbreak of World War II, his bold and superbly drafted paintings lay in Matson's basement until 1948, at which time they were reproduced as menu covers aboard the S.S. Lurline.
In 1951, Savage's genius was honored at a display of American Lithographs at the Smithsonian Institute.
It is estimated that over a quarter of a million Savage menu covers were distributed between 1948 and 1956, and today, his beautiful menu covers are highly prized by discerning collectors of Hawaiian ephemera.
Eugene Savage, a native of Covington, Indiana, died in 1978, at the age of 95. Here, we offer brilliant reproductions of his most popular pieces faithfully executed by Ricardo San Pedro.
Lahaina Printsellers custom-prints this image on waterproof canvas in our Lahaina studio using only the finest archival inks, which are tested and guaranteed not to fade or shift under normal circumstances for over 100 years.
Copyright © 2019 Lahaina Printsellers, Ltd. All Rights Reserved.


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Biological Sciences
Research Highlights
July 2010
Thousands of New Proteins Discovered in Spinal Fluid
Research establishes healthy benchmark to aid in understanding neurological disorders
A U.S. and Swedish team identified 2,630 proteins in the clear fluid that protects the brain and spinal cord. Enlarge Image
Results: Scientists and doctors have a far better understanding of the proteins in healthy spinal fluid, thanks to a U.S., Swedish team who identified 2,630 proteins in the clear fluid that protects the brain and spinal cord. This discovery nearly triples the number of proteins known to exist in spinal fluid. Another striking finding was that slightly more than half of the proteins were not found in blood.
The team was led by Richard D. Smith, Ph.D., of Pacific Northwest National Laboratory, and Steven E. Schutzer, MD, of the University of Medicine and Dentistry of New Jersey—New Jersey Medical School.
In conducting this research, the team used integrated resources at EMSL that included a custom-built automated nanocapillary liquid chromatography system coupled on-line to one of two mass spectrometers, modified in-house with an electrodynamic ion funnel.
Why it matters: This research establishes a reference database that may help researchers and clinicians determine the root causes of Alzheimer's, Parkinson's, and other neurological conditions. In addition, this work could improve the chances of devising faster, more efficient diagnostic tests and treatments for diseases with neurological and psychiatric features.
What's next: While this work is the most comprehensive characterization of normal spinal fluid to date, it is only the beginning. Quickly and precisely determining the proteins in different samples opens doors to fundamentally understanding human health.
"These exciting findings are the tip of our research iceberg," said Smith, a Wiley Research Fellow at the Department of Energy's EMSL.
Acknowledgments: The National Institutes of Health, the National Center for Research Resources, the Swedish Research Council, and Uppsala Berzelii Technology Center for Neurodiagnostics supported this research. Key work was done at the DOE's EMSL, a national scientific user facility at Pacific Northwest National Laboratory.
This work was done by Steven Schutzer and Benjamin Natelson of the University of Medicine and Dentistry of New Jersey; Tao Liu, Tomas Angel, Athena Schepmoes, Samuel Purvine, Kim Hixson, Mary Lipton, David Camp II, and Richard Smith of Pacific Northwest National Laboratory; Patricia Coyle of State University of New York; and Jonas Bergquist of Uppsala University in Sweden.
Reference: Schutzer SE, T Liu, BH Natelson, TE Angel, AA Schepmoes, SO Purvine, KK Hixson, MS Lipton, DG Camp II, PK Coyle, RD Smith, and J Bergquist. 2010. "Establishing the Proteome of Normal Human Cerebrospinal Fluid." PLoS One 5(6):e10980. DOI: 10.1371/journal.pone.0010980.
For more information, see the press release from the University of Medicine and Dentistry of New Jersey.


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REAL ESTATE- $old
Parkside at Charlottesville L|LC to Michael C. Schovel, condominium unit at Parkside at Eagle's Landing, 727 Denali Way, $259,900.
Parkside at Charlottesville LLC to Linda M. Carter, condominium unit at Parkside at Eagle's Landing, 142 Yellowstone Drive, $259,900.
Parkside at Charlottesville LLC to Darren Gryniuk, Colby J. Reilly, and Michael Riolo, two condominium units at Parkside at Eagle's Landing, 140 Yellowstone Drive and 765 Denali Way, $519,800.
Carter F. and C. Wilson McNeely III to Lisa L. Casinella, 4.39 acres at 2834 Jones Mountain Lane, High Meadow, Crozet, $450,000.
Gaffney Homes LLC to Steve and Amy Gawtry, 2.0 acres at 1933 Old Ballard Farm Lane, Old Trail, $1,150,000.
Jigar A. and Jesika J. Patel to Felix M. and Rosa E. Hernandez, 0.046 acres at 4731 Blue Jay Way, Briarwood, $272,900.
Mayank K. and Sejal M. Gala to Sarah E. Brown, 1536 Minor Ridge Court, Minor Townhouses, $215,000.
Sandra Lee Medura to Tony D. and Janie D. Barnes, 2.0 acres in Rivanna Magisterial District, $40,000.
Old Trail Creekside LLC to Old Trail Homes LLC, lot in Old Trail Creekside, $230,000.
Meadow Wood Inc. to Kenneth S. and Sara E. Nitcher, condominium unit in Villas at Southern Ridge, $159,950.
Charles W. Hurt, trustee, to William W. Allen, 21.039 acres at Fray's Grant, $450,000.
Margaret A. and Edward R. Laws Jr. to Abigail Turner, 2.516 acres at 555 Rodes Drive, Greencroft, $840,000.
Southland Homes Inc. to Bruce C. and Bobra F. Locker, 0.508 acres at 2576 Montgomery Ridge Road, Montgomery Ridge, $560,125.
Paul and Julia Given to Stefan Lalos, 118 acres at 2920 Miller Lake Road, Batesville, $1,050,000.
Timothy G. Bobbit, trustee, to Letitia M. Locker, 0.135 acres at 1113 Marion Drive, Ednam, $495,000.
Alan J. and Barbara D. Drinkwater to Amanda Moore, 106 Woodlake Drive, Four Seasons, $189,000.
Joshua A. Goldschmidt to Church Hill Rentals LLC, parcels in Ballard Field, Old Trail, gift.
Tracy E. Adams to Jiangtao Meng and Ran Zhao, 1614 Townwood Court, Townwood, $195,950.
Anne E. Townsend, trustee, to Hurt Investment Company, two lots in South Ivy subdivision, $350,000.
Gaffney Homes LLC to John R. and Gaytri P. Scheel, 0.459 acres at 1225 Hatcher Court, Mosby Mountain, $499,000.
Jeremy and Cristina Murray-Krezan to Douglas Howard and Crystal Dawn Johnsen, 0.106 acres at 263 Albert Court, Camellia Gardens, $189,900.
Larry and Erica Barber to Cassio Valintim DeAndrade, 0.113 acres at 3388 Moubry Lane, Forest Ridge subdivision, $260,000.
Alfredo J. and Deborah M. Hernandez to Stephen M. McKinney and Soon M. Ohk, 0.203 acres at 1032 Hayrake Lane, Redfields, $271,000.
David J. and Maureen A. Barber to Phuong K. Huynh and Duyen K. Duong, 124 Woodlake Drive, Four Seasons townhouse, $189,500.
Vicky Gibson to Phuc Q. and Thien D. Pham, 0.205 acres at 302 Camelot Drive, Camelot, $225,000.
Jacqueline H. Asplin to David C. Alley, 302 Lake Forest Lane, Four Seasons, $264,000.
Patricia N. Ignatiadis to North River Partners LLC, 2.023 acres at 1348 Huntersfield Close, Keswick, $675,000.
Jennifer Law to Kyle S. Rodland and Megan A. Lowry, 577 Southampton Court, Stonehenge, $221,250.
Dana M. and Richard Stokes to Margaret P. Pearson, 0.3346 acres at 332 Copper Hill Drive, Mill Creek South, $325,000.
R. Shawn Majette, trustee, to Two Dog LLC, 2604 Huntington Road, Northfields, $290,000.
Pedro C. and Anita O. Alviso to Serge Rascle and Penny Chang, 0.299 acres at 6073 Cling Lane, Crozet Crossing, $183,000.
Larry D. and Jennifer S. Kirby to Erik J. and Erin P. Irtenkauf, 0.295 acres at 3168 Timberwood Parkway, Timberwood, Forest Lakes, $289,500.
Franklin W. and Patsy F. Nash to Gary E. and Florence V. Hensley, 0.738 acres at 1980 Owensville Road, $206,000.
Carolyn D. Proctor to William F. and Carol L. Morton, 3551 Burnley Station Road, Barboursville, $275,000.
Jian Hua Huang to Megan Wortman, 1474 Minor Ridge Court, Minor Townhouses, $215,000.
Cary T. Ladd Jr. to Arnold W. Crawford Jr., 3.0 acres at 591 Huckstep Branch Lane, Keswick, $48,000.
Carmen Ramirez and Betsy M. Maldonado to Betsy M. and Bryan G. Sauer, 0.181 acres at 334 Bennington Road, Bennington Woods, $55,000.
Steven L. Peters to Michael R. Durham, 28 acres on State Route 735, $220,000.
Hauser Homes Inc. to Meredith F. Thomasson, 0.063 acres at 916 Poplar Glen Road, Poplar Glen subdivision, $581,030.
Medallion Enterprises LLC to Charles B. and Elizabeth M. Wakely, 0.196 acres at 5065 Brook View Road, Ballard Field, Old Trail, Crozet, $672,994.
Preston Scott and Elizabeth Lawhorne to James T. and Brenda G. Clifford, 2.132 acres at 3696 Green Creek Road, Green Mountain subdivision, Schuyler, $164,400.
Jonathan D. and Melissa K. Heavey to Robyn M. Templeton, 0.133 acres at 977 Devon Spring Court, Redfields, $252,500.
Ronald T. Shaw, trustee, to Kathryn M. and William S. Flippen Jr., 0.328 acres at 998 Dunlora Drive, Rivercrest of Dunlora, $460,000.
Ellen R. Barber to Harry M. Phelan III, 31 Ednam Village, $900,000.
Kenneth R. and Gayle Power to Marilyn L. and David G. Smith, 8.949 acres at 3961 Taylors Mountain Farm Lane, $634,000.
Michael J. and Kathryn B. Sherwood to Daniel G. and Angelique S. Krasnegor, 4.172 acres at 25 Rosyln Heights Road, Roslyn Heights, $576,500.
Parkside at Charlottesville LLC to Ronald W. and Gwen S. Moseley, condominium unit in Parkside at Eagle's Landing, 142 Yellowstone Drive, $359,900.
Alexander H. and Anne Ridder Jordan to Michael V. Anello, 28.78 acres at 6200 Blenheim Road, Scottsville, $930,000.
Lois S. Keeney to Arthur M. and Karen H. Sherwood, 0.488 acres at 1088 Blackburn Bluff, Dunlora, $605,000.
Albemarle One LLC to Roman Homes LLC, 3.46-acre lot 14, Chestnut Ridge, 770 Cleopatra Court, $205,000.
Imogene F. Morris to Gary W. Morris, interest in 39 acres in White Hall Magisterial District, $68,725.
Jerome R. Morris to Gary W. Morris, interest in 39 acres in White Hall Magisterial District, $68,725.
Shiflett Farm LLC to Hauser Homes Inc., three lots in Westhall subdivision, $252,000.
Weather Hill Homes Ltd. to Hauser Homes Inc., eight lots in Poplar Glen subdivision, $1,040,000.
John B. and Carol A. Szczyglinski to Andrew and Barbara Bastone, 0.549 acres at 1736 Mattox Court, Mosby Mountain, $475,000.
Dorothy T. Davis to Brian S. and Monica L. Johnson, 945 Owensville Road, Meriwether Hill, $370,000.
Big Deal
Alexander H. and Anne Ridder Jordan to Michael V. Anello, 28.78 acres at 6200 Blenheim Road, Scottsville, $930,000.


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Find us on:
The mission of the National Institute of Arthritis and Musculoskeletal and Skin Diseases is to support research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases; the training of basic and clinical scientists to carry out this research; and the dissemination of information on research progress in these diseases.
Review Date: Wednesday, July 20, 2011
List reviewed web resources
The clearinghouse provides information about various forms of arthritis and rheumatic disease and bone, muscle, and skin diseases in English, Spanish and Chinese. It distributes patient and professional education materials and refers people to other sources of information.
The National Psoriasis Foundation is the world's largest nonprofit patient advocacy organization serving the 7.5 million Americans with psoriasis, the most common autoimmune disease in the country, and psoriatic arthritis, an inflammatory arthritis that affects the joints and tendons. Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education. The Psoriasis Foundation has grown to become the largest charitable funder of psoriatic disease research worldwide and directly supports the most promising early-state research and emerging scientists. Advocacy staff work to shape the laws and policies that affect people with psoriatic diseases by advancing a public policy agenda to secure more federal funding for psoriatic disease research and work to remove barriers that limit access to care.
The Foundation provides extensive patient and medical education through events, publications and medical outreach. Headquartered in Portland, Ore., the Foundation has local community-based divisions in Los Angeles, San Diego, Northern California, Chicago, Dallas/Ft. Worth, South Florida, Florida West Coast, New York City and Portland, Ore.
Review Date: Wednesday, October 14, 2015
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|Tom Brady is no stranger to pain (source)
This week in SWAG we read an article about racial biases in perceptions of others' pain. The American medical field has a long history of racial bias (Note: I think if you switched the words "medical field" with almost any other field, the sentence would be factually accurate. For example, "mathematics field" or "psychology field" but not "magnetic field"). American blacks tend to be diagnosed less accurately by medical staff than whites, to receive less optimal health care, and to be cared for less intimately. The authors, led by Sophie Trawalter of the University of Virginia, wondered about the source of this racial bias. They reasoned that it might arise in part from a belief that low status groups experience less pain than other groups in society. Blacks and other traditionally low status groups in America are perceived as having overcome greater hardships throughout their lives. As a result of contending with, and overcoming these hardships, low status groups are perceived to experience less pain than their more advantaged counterparts—their tough circumstances have made them tougher. This racial bias in pain perception is theorized to underlie the black-white treatment gap in medicine.


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Although we have no idea what it actually looks like, the Lumia 928 and its camera are sure getting a work out. Yesterday we saw numerous photos leak that were taken with the 8.7MP camera (and even front-facing one) and today from the same source we evidently have more.
We say evidently because some of these photos are missing EXIF information, the crucial data that is embedded in each photo, often revealing the device name, lens, f-stop, etc.; having said that it's clear that these photos are from the same day as the previously verified photos, so it's a safe assumption that this is part of a set.
For those curious, the pics come via a private blog that is not open to the public. Ironically though (and much like a Facebook exploit) photos evidently are visible and were pulled by the site Nokia Power User.
At this point we can't make too much of these photos as we don't have controls to compare it to and we're maybe dealing with pre-release software. Likewise, photos taken on bright sunny days generally always look good and these are no different.
Hopefully we'll have more than just camera samples from the Verizon Lumia 928 in the coming days. The phone is expected to launch sometime next month on the carrier, bringing with it the first serious competition to AT&T and its dominance on Windows Phone.
Source: Nokia Power User; Thanks, Jaseel E., for the tip


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Views: 213
Replies to This Discussion
Hi Jonathan, I can play in evenings on any days. How is your schedule?
Does any one wants to play in evenings at Lake Nona YMCA or Narcossee-Moss Park courts?
Yes i can at 4 then right?
Can you play tomorrow morning at Lake Nona YMCA?
Unless you want to play at Narcossee and Moss Park tennis courts tomorrow at 4 pm.
I can only come there on Saturday morning?
Does that work for you?
Otherwise next week in the evening.
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Once again, it's time for the Weekly Kids Co-Op, which always has so many creative activities linked-up. Lately, I've been sharing great blog projects from Co-Op participants, such as Small Hands Creating Hope (so far over $1k raised for the American Cancer Society) and From the Mouth of Mamas from B. Inspired Mama!, a weekly series in which she shares "kid-tested tips and parenting solutions for a specific parenting challenge 'from the mouths of moms.'"
This week, it's Awesomely Awake's 31 Days to a More Meaningful Summer, a FREE e-course - don't worry, there won't be a test. You'll just receive daily emails with tips, activities, recipes, etc. focused on helping you have a great summer with your family!
If we can all just stop being sick at our house, we can focus on having an awesome, meaningful summer with more beach days like this one!
Make it Meaningful! Have Fun! Play!


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The Southampton Double White poured a hazy, light golden yellow color with a pen-width white head. The aroma had mostly wheat with strong citrus and spice notes.
The body is smooth on the palate but crisp around the edges. There is a lot of wheat and a light sweetness up front. Bananas are apparent as well as citrus notes that lead to a very nice light finish with a light tart/sour aspect.
The beer left a small amount of spotted lace on the glass.
Overall, this is a great beer, a refreshing white ale that is perfect for hot summer days. The ABV is fairly high for a wheat so downing a six pack is not likely.
This beer is fairly versatile when pairing with food. Southampton Double White would go great with a light romaine salad made with pairs as well as a flaky white fish cooked with some white wine and garlic.Producer: Southampton Ales & Lagers
Price: $2.25 (12 oz. Bottle)
Rating: (3.5 out of 5 | Very good-to-Delicious)


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Wiki Monkey
Wiki Monkey is a MediaWiki-compatible bot and editor assistant that can be used directly within wiki pages in the browser as a user script. Currently it is tested on Firefox, Chromium and Opera, but it is very likely to work also on other browsers out of the box or with minor adaptations. Wiki Monkey can also be easily extended through the creation of plugins, exploiting its API.
The project is currently focused on ArchWiki, and as such most plugins address ArchWiki-specific problems.
- 1 Installation
- 2 Configurations table
- 3 Updates
- 4 Tour of the features
- 5 Contributions
- 6 See also
Make sure you have installed either the Scriptish extension (recommended) or the Greasemonkey extension.
Now just click on the link of one of Wiki Monkey configurations from the "Scriptish/Greasemonkey/Tampermonkey" column in the #Configurations table and your browser should ask you to install it.
Wiki Monkey can be installed in two ways: either using Tampermonkey or exploiting Chromium's native support for user scripts.
Tampermonkey (recommended)
Make sure you have installed the Tampermonkey extension.
Now just click on the link of one of Wiki Monkey configurations from the "Scriptish/Greasemonkey/Tampermonkey" column in the #Configurations table and your browser should ask you to install it.
Native support
Just click on the link of one of Wiki Monkey configurations from the "Chromium native" column in the #Configurations table and your browser should ask you to install it.
Go to: Opera menu > Settings > Preferences > Advanced > Content > JavaScript options: in the User JavaScript folder field, select the directory where you will install user scripts.
Now download one of Wiki Monkey configurations from the "Opera" column in the #Configurations table and save it in the folder you've chosen earlier.
Other browsers
Configurations table
This is the table with the predefined configurations: read the section above for instructions on which link you must choose.
|Chromium native
|Provides only manual-editing aid functions in editor pages
|Provides a quick-report function in diff pages
|Editor + Patrol-Lite
|Patrol + automatic operations on list pages
Alternatively, you can create your own configuration.
Open Firefox's Add-ons Manager (Tools -> Add-ons), select User Scripts, right-click on Wiki Monkey and choose Find Updates.
If you want to enable automatic updates, choose Show More Information instead, then set Automatic Updates to On.
Scriptish's perferences are available in Firefox's Add-ons Manager (Tools -> Add-ons), selecting the Extensions tab.
Greasemonkey should enable automatic updates by default, you can check opening Firefox's Add-ons Manager (Tools -> Add-ons), selecting User Scripts, right-clicking on Wiki Monkey and verifying Automatic check for updates is ticked.
Greasemonkey's perferences are available in Firefox's Add-ons Manager (Tools -> Add-ons), selecting the Extensions tab.
Tampermonkey should enable automatic updates by default, you can check opening Tools -> Extensions, selecting Tampermonkey's options, selecting the Settings tab and verifying the settings for Check Interval in the Script Update section.
Native support
Chromium's native support for user scripts is rather limited and should not be able to update Wiki Monkey. If you want automatic or semi-automatic updates, it is recommended to use Tampermonkey as described in the Installation section.
Due to how user scripts are installed in Opera, there is currently no way to have automatic or semi-automatic updates, you will have to check periodically and reinstall the script when a new version is released.
Tour of the features
After installing the desired version of Wiki Monkey, start visiting the editor of this very page, you will find Wiki Monkey's interface right below the Save page button row. As you can see there are some buttons, each of which will execute a plugin action (see Bundled plugins for detailed information):
- Fix header reorders the elements in the header, warns about possible problems (e.g. lack of category) and tries to fix some.
- Fix headings tries to fix the levels of section headings so that they start from level 2 and do not increase by more than 1 level with relation to the parent section.
- Use code templates replaces
<tt>with Template:bc and Template:ic, taking care of adding numbered parameters or
<nowiki>tags when necessary.
- Expand contractions expands some common English contractions, e.g. "don't" becomes "do not".
- Multiple line breaks compresses multiple empty lines into one.
- RegExp substitution lets you perform a regular expression substitution.
- Sync interlanguage links * synchronizes the interlanguage links of the edited page with those of its translations.
- Fix old AUR links ** converts direct AUR-1.x package links to instances of Template:AUR.
By pressing one of them, the text in the editor will be modified, but note that the page will not be saved, so you will still be able to see the diff or the preview and perform other modifications manually. The Execute row and Execute all buttons are used to execute more plugins one after the other, thus saving some clicks.
At the bottom of Wiki Monkey's interface you will always find the log area, on dark background, where Wiki Monkey and its plugins will output their messages.
Now, if you have installed the "Patrol Lite", "Patrol" or "Bot" configuration, visit Special:RecentChanges and select a diff from the list: right below the diff panes you will find Wiki Monkey's interface. Here the only bundled plugin is Quick report, which adds a row with a link to the visited diff in the specialized table of ArchWiki:Reports.
At this point, if you have installed the "Bot" configuration, visit Special:SpecialPages: at the top of the page you will find those plugins that have a generic purpose and are not based on a specific page: the only currently available plugin is a function to update Table of Contents pages.
Finally, if you have installed the "Bot" configuration, visit the Category of this article: right at the top you will find Wiki Monkey's bot interface, whose usage is explained in the upstream documentation; other pages where you can find the bot are What Links Here pages and many of the list pages linked from Special:SpecialPages. The available plugins for the bot are a regular expression substitution function and a tool for synchronizing the interlanguage links of the pages with those of their translations*. The External links search page also provides a plugin for converting direct AUR-1.x package links to instances of Template:AUR**.
* The Chromium-native, Opera and standalone configurations can only synchronize local languages.
** Available only for the Scriptish/Greasemonkey/Tampermonkey configurations.
Of course any help in the resolution of bugs or the development of new plugins is appreciated: if you are interested, send an email to the original author (or use his talk page) and urge him to finally complete the documentation about the development of plugins, which is actually quite straightforward.


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What's New in Taskmaster
Version 3.17.1: Release notes were unavailable when this listing was updated.
Requirements for Taskmaster
- OS X 10.7 or later
Similar Software
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- Games Hack Generator
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- Download the hack tool and enter it. Go to settings tab (check screenshot) and add your Facebook Account ID
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Hi all,
I'm almost certain the answer will be a very simple yes but thought I'd check. Are Shimano 10 speed bar end shifters compatible with Shimano 10 speed RDs? I think my MTB is going to become a MonsterCross bike but trying to decide if I want to run gears or not. If I do a bar end shifter will be the way I go.


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For fitness activities other than hiking, we offer excise and yoga classes. À la carte activities include Registered Dieticians, cooking demonstration, Personnel Trainers, horseback riding, canoeing, fly fishing, clay shooting, bird watching, rock climbing, caving, cycling and mountain biking.
We provide an all inclusive vacation with affordable accommodations, spa cuisine and experienced guides that will maximize this unparalleled Vermont vacation. Unlike other spas where guests spend a good deal of their time on the spa property, we encourage our guests of all physical abilities to explore Vermont.
ATA has two Registered Dietitian on staff, Rosa Donohue MS, RD, CND and Jill Corey MS, RD both have a Master of Science in Clinical Nutrition. They have created our delicious spa menu and work daily with our chefs. Our meals are a healthy balance of carbohydrates, proteins and healthy fats. We offer a vegetarian option at every meal and cater to special diets, such as vegan, wheat and dairy-free options.
HIKING PROGRAMS: The majority of our hikes are in the Green Mountain Nation Forest along the Appalachian Trail and Long Trail, the oldest long distance hiking trail in the country.
Our PEAK BAGGING PROGRAM is for those advanced hikers will have the opportunity to hike all five of Vermont's 4,000 foot mountains. Those who summit all of Vermont's 4,000 footers are awarded with a certificate of accomplishment. This accomplishment in the hiking community is referred to as a peak bagging.
Our VERMONT'S VISTA and VILLIAGE VACATION takes intermediate and novice hikers to Vermont's most scenic vistas, to a waterfalls, a historical mine, or to a beautiful crystal clear lake.
At the Summit Lodge, you'll find some of the finest recreation anywhere. In summer, hone your racquet skills on our tennis court, then cool off in our outdoor heated pool. Enjoy an energizing workout in our exercise room, a warm relaxing Finnish sauna, or a steaming whirlpool. In the evening, enjoy fireside dining and fine cuisine in our antique-filled dining room
other anenties include: outdoor tennis court, air Conditioning available, Small library, Public computer, wireless Internet and Internet Access. Very Friendly Pub Comfortable "Parlor" with Board Games, Library, Piano and Organ! Indoor and Outdoor Swimming Pools, Whirlpool, Sauna, Table Tennis Croquet, Billiards, Color TV, Hair dryer, Iron and Ironing Board Available
|Map Legend
|Guided Hiking Vacations & Healthful Livi
142-244 Summit Rd, Killington, VT 05751, USA
|single Occ
|Double Occ
|1-2 Nights
|per person per night
|per person per night
|7-14+ Nights
|per person per night


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Acclaimed by critics, scholars and pastors of every major denomination in America, Frank Runyeon tours his dramas and comedies to 40 states a year. More than 2,000 Catholic and Protestant churches have hosted his productions and given rave reviews.
As a Christian youth speaker, he is consistently rated "the best we've ever heard."
We hope your community will host a performance this year!
Youth ministers and faith educators agree: "Our teens believe what they hear from the media more than what they hear in church."
Credible, hip, and tremendously entertaining, in HOLLYWOOD vs. FAITH ,Frank is able to open eyes in a way few youth speakers can:
"Our Confirmation candidates called it amazing!"
kids were texting each other...how great it was"
Ideal for faith formation, confirmation retreats and youth events, HOLLYWOOD vs. FAITH is also great combined with SERMON ON THE MOUNT as a special event for the whole family. It's eye-opening and entertaining for all ages.
Read more about HOLLYWOOD vs. FAITH
Call a church near you for a reference
Frank Runyeon starred opposite Meg Ryan on CBS, and in more than 1,000 TV episodes and movies, before leaving Hollywood to attend seminary.
He studied at:
For 25 years, Frank has helped audiences of all ages:
He was nominated for a Daytime Emmy for a recent guest appearance on CBS.
Read Frank's full BIO