In a grinding machine, a bed 10 has secured thereon a work head 11 which rotatably supports a work spindle 12 for supporting a workpiece W and mounts thereon a slide base 15 reciprocatively movable in a Z-direction parallel to the axis of the work spindle, and a wheel head 16 carrying a rotating grinding wheel 17 is reciprocatively movable on the slide base in an X-direction intersecting with the Z-direction. A measuring device 25 for measuring the dimension of the workpiece ground with the grinding wheel is mounted on an extreme end of a support arm 21 secured to the slide base to extend in the X-direction, through an actuator device 23 which is operable for moving the measuring device between a measuring position for engagement with the workpiece and a parked position for disengagement therefrom. The support arm passes over the workpiece, or passes through a space between the bed and the workpiece, or passes through the inside of the bed.

1. Field of the Invention
The present invention relates to a mounting structure for a measuring device which measures the dimension of a ground portion for performing a grinding while controlling the dimension of the ground portion. Particularly, it relates to a mounting structure for a measuring device which is designed for use in a cylindrical grinding machine. Further, the present invention relates to a grinding machine with the mounting structure.
2. Discussion of the Related Art
Cylindrical grinding machines generally take the construction that a bed has mounted thereon a work head having a work spindle for rotatably supporting and driving a workpiece and a wheel head having a rotating grinding wheel and that the work head and the wheel head are relatively moved in a Z-direction parallel to the rotational axis of the work spindle and an X-direction perpendicular thereto to grind the workpiece. Such cylindrical grinding machines are classified into a table traverse type that the grinding operation is performed by moving a table with the work head fixed thereon on the bed in the Z-direction and by moving the wheel head on the bed in the X-direction and a wheel head traverse type that the grinding operation is performed by moving the wheel head relative to the work head fixed on the bed in two directions of Z and X. The table traverse type has heretofore been the mainstream of cylindrical grinding machines, wherein the length of the machine in the Z-direction becomes long because a table elongated in the Z-direction is moved in the Z-direction. However, these days the wheel head traverse type is becoming the mainstream of cylindrical grinding machines because of an increasing demand for the downsizing of the machines. In the wheel head traverse type, it is general to take the construction that the wheel head is mounted movably in the X-direction on a slide base which is mounted movably on the bed in the Z-direction.
In the table traverse type, on the contrary, it is ordinary to mount a measuring device on a pillar upstanding at a front portion of the bed which is adjacent to the grinding wheel in the Z-direction and which is on the side opposite to the grinding wheel in the X-direction. With this construction taken, it does not occur that the grinding wheel and the measuring device are moved relatively in the Z-direction even when the workpiece is moved relative to the grinding wheel in the Z-direction. Therefore, any ground portion on the workpiece can be measured at all times by the measuring device remaining in front of the grinding wheel, so that a mounting structure for the measuring device can be simplified. By the way, in cylindrical grinding machines, an opening which can be selectively opened for the loading/unloading of the workpiece as well as for the maintenance of attachments provided in a grinding area is provided at a front part of a cover for preventing coolant supplied to the grinding area from splashing. In the aforementioned mounting structure for the measuring device, since the same is arranged around the opening portion of the cover, there arises a problem in that the mounting structure becomes an obstacle in performing the loading/unloading of the workpiece and the maintenance of the attachments. For the purpose of solving the problem, it has been practiced to arrange the measuring device at an end part of the opening portion or at a part being within the cover but being deviated from the opening portion, in which case a resultant problem arises in that the adjustment and maintenance of the measuring device per se becomes difficult to perform.
In the wheel head traverse type, on the other hand, it is first conceivable to mount the measuring device on the bed. With this structure taken, the measuring device cannot be moved relative to the workpiece, and thus, where grinding operations are to be performed on ground portions of a workpiece which are spaced at plural places in the Z-direction, measuring devices for the respective ground portions have to be provided, resulting in an increase in the facility cost. Further, where workpieces respectively having ground portions at different positions in the Z-direction are to be ground in succession, there arises an inconvenience that the position of the measuring device has to be changed each time of one grinding operation. Further, like the table traverse type as aforementioned, there arises a problem that the measuring device positioned at the opening portion of the cover makes an obstacle against the maintenance and adjustment of various attachments therearound. As a measure for solving these problems, there have been known a structure that a measuring device is mounted movably in the Z-direction on a bed or a member such as a table mounting a work head thereon and another structure that a measuring device is mounted on a wheel head.
The structure that the measuring device is mounted movably in the Z-direction is disclosed in Japanese Utility Model No. 2601057 for example. In the know structure, as shown in FIGS. 1 to 3 of the Japanese Utility Model, a slide table 6 is mounted movably in the axial direction of a work spindle 3a on a table 2, which mounts thereon a work head 3 and a foot stock 4 for supporting a workpiece W, on a side opposite to the side where the machining of the workpiece W is performed, and the slide table 6 is provided with a servomotor 11 driven in response to a signal designating the workpiece or a measuring position on the workpiece W and a conversion mechanism 14-19 for converting the rotation of the servomotor 11 into the reciprocating movement of the slide table 6, wherein a measuring device main body 10 is secured on the slide table 6. With this structure, it can be realized to automatically move the measuring device main body 10 to any programmed measuring position on the workpiece W, and it becomes possible to evacuate the measuring device main body 10 to a suitable position where the measuring device main body 10 does not interfere with the loading/unloading of the workpiece and the maintenance for attachments provided in the grinding area.
Further, the structure for mounting the measuring device on the wheel head is disclosed in Japanese Unexamined, Published Patent Application No. 2000-127038. As shown in FIGS. 1 and 2 of the Japanese Application, the application relates to a grinding machine with twin wheel heads 8, 9, wherein measuring devices 20 are mounted on the top surfaces of the respective wheel heads 8, 9. More specifically, each wheel head mounts a support member 21 for the measuring device 20 on the top surface thereof, a second arm 23 is pivotably carried at an extreme end of a first arm 22 which is pivotably carried by the support member 21 to extend forward, and a measuring rod 28 for measuring dimensions is secured approximately at right angles to an extreme end of the second arm 23. The measuring rod 28 is composed of a V-block 25 secured at an extreme end thereof and contactable with the outer surface of a crankpin CP to be machined and a probe 27 provided at the center part of the V-block 25 to be movable back and forth and electrically detects the back and forth movement of the probe 27 to output the detected movement as an electric signal. The measuring device 20 is provided with an actuator or hydraulic cylinder 31 for moving the measuring rod 28 selectively to a parked position and a measuring position. In the measuring device 20, the hydraulic cylinder 31 turns the first arm 22 upward to hold the measuring rod 28 at the parked position as indicated by the phantom line in FIG. 2 of the Japanese application, in which state the second arm 23 pivotable about the extreme end of the first arm 22 would not be held at a fixed position. With this taken into account, a third arm 24 is secured to the extreme end of the first arm 22 to extend downward, and a support protrusion 29 at the extreme end of the third arm 24 holds the second arm 23 at the fixed position while the measuring device 20 is at the parked position. The measuring device 20 needs a complicated link mechanism as aforementioned for the purpose of holding the V-block 25 and the probe 27 in contact with the outer surface of the crankpin CP to be ground, in a predetermined relation even though the wheel head 9 is moved in the X-direction during each grinding operation.
As described above, in the wheel head traverse type, the structure that mounts the measuring device on the member supporting the work head, to be movable in the Z-direction requires the slide table, the servomotor for operating the same and the conversion mechanism for converting the motor rotation into the reciprocating movement of the slide table and thus, unavoidably results in a substantial increase in the facility cost. Further, in the wheel head traverse type, the structure that mounts the measuring device on the wheel head requires the complicated link mechanism as aforementioned and thus, also unavoidably results in an increase in the facility cost. In addition, the link mechanism needs considerable rigidity for higher measuring accuracy of the measuring device and is increased also in weight. Because this results in further increasing the weight exerted on the top surface of the wheel head which is supported to be movable in the X-direction on the slide base which is in turn supported on the bed to be movable in the Z-direction, there is a risk of deteriorating the feed accuracy and the positioning accuracy of the wheel head. Further, the addition of the large weight mechanism to a high position may have a risk of generating chattering vibration. Furthermore, since electric wires and hydraulic conduits for the measuring device suffer bending and stretching in two directions of Z and X, there arises an additional problem involving a risk of breaking or damaging the electric wires and the hydraulic conduits.

Mounting structure for measuring device and grinding machine with the structure


A centrifugal fan comprises an impeller, a motor which is connected and rotates the impeller and a housing which has an intake and an air blowing port for housing the impeller. The impeller has a plurality of blades arranged on a circumference. The intake opens opposed to the right end (in FIG. 1) of the impeller. The air blowing port opens opposed to a side of the impeller. A gap enlarged portion, in which the distance between the outer circumference of the impeller and the inner face of the housing starts to increase at a point where the distance between the outer circumferential of the impeller and the surface of a nose portion is smallest therein, the nose portion being a region of the vicinity of an edge portion of the air blowing port, the edge portion being the closest side to the outer circumference of the impeller.

1. Field of the Invention
The present invention relates to a centrifugal fan, and particularly, the present invention relates to a centrifugal fan that is used for cooling electric products and electronic devices.
2. Background Art
In recent years, the electronic devices are made compact and are provided with high performance. In accordance with this, a cooling fan that is mounted in the electronic device is required to be downsized. In response to downsizing of the electronic device, parts are made highly integrated. Thus a density in a chassis of the device becomes high. Therefore, the cooling fan that is mounted in the electronic device is required to have a high static pressure and large air volume.
Conventionally, a structure of arranging a compact cross flow fan on a heat sink for heat release has been known. However, the compact cross flow fan cannot acquire a high static pressure.
In addition, conventionally, a centrifugal fan that is made thin in an axial direction by making a radius of an impeller shorter than a length of the centrifugal fan in an axial direction has been known. However, in order to acquire required air volume and static pressure, a sectional area orthogonal to an axis is made larger, so that further downsizing is required.
Further, in the fan that is mounted in the electronic device, a noise should be decreased.
A first object of the present invention is to provide a downsized centrifugal fan having a high static pressure and an increased air volume, a second object of the present invention is to provide a downsized centrifugal fan, and a third object of the present invention is to provide a centrifugal fan having noise decreased.


A control system for the manufacture of a product is disclosed. A network of events and activities and a baseline schedule is constructed. Actual and predicted deviations to the baseline schedule, which are called slack variables, are used to predict the actual final completion date, using parallel processing. These slack variables are also used to selectively allocate resources to elements of the manufacturing process. Critical elements and critical dates are readily determined. The incremental cost of incremental schedule improvement can be readily determined. The current status of a project can be described in a single variable.

This invention is directed to a control system for the production of a product. The control system of this invention has the capability of rapid information processing and display, minimizing production cycle time, efficiently allocating resources, and minimizing excess costs.
In the production of products, the work effort is a sequence of operations. The proper control of these operations is as important to the efficient transformation of the product from its initial state into its finished state as the individual operations themselves. Just as an improvement in each operation can improve the production rate, an improvement in the control of the production process can produce a similar reduction in total cost and the elapsed time of production.
For example, in U.S. Pat. No. 3,703,725, the method of control uses a computer to balance work flows in a manufacturing process. In U.S. Pat. No. 3,845,286, a control system sequences semiconductor wafers through a number of workstations. In U.S. Pat. No. 4,027,246, a central computer controls the transfer and processing of semiconductor wafers. Although these inventions teach methods for manufacturing control, and an improvement in efficiency, they do not teach a method for maximizing manufacturing efficiency and thereby minimize manufacturing time and cost. In the production of any product, the costs of idle waiting time, penalties due to late delivery, unjustified expediting costs, and the costs of excess inventories must be minimized.
One system that has addressed this problem is the Critical Path Method (CPM), in which a network of activities is created that represents the sequence of operations and the interdependencies of the operations in the particular production process. A variation on this basic method is Project Evaluation and Review Technique (PERT) which uses multiple estimates of time durations to provide a probabilistic output. These systems are available as computer software. To use these systems, the networks are analyzed to fine the critical path; i.e., the path that is, in effect the longest duration, and which determines the final completion date.
A major problem of these systems is that critical items that lie on the critical path must be searched serially; each requiring a computer run, at a considerable expense in time and money on large projects. Also, potentially critical items are not identified. Further, for every change in the availability date of any item, the impact on the final completion date can only be assessed by another computer run. Although valuable, these systems do not provide an easy and timely visability into the critical items and their degree of impact. Also, these systems do not offer a means to balance resources in order to minimize the time and cost of a project.

Method for resource allocation and project control for the production of a product


Disclosed is an oral sustained-release preparation which contains at least one active ingredient selected from the group consisting of fasudil hydrochloride and a hydrate thereof, the preparation comprising at least one sustained-release coated particle comprising a core having a surface and a coating formed on the surface of the core, wherein the core contains the active ingredient and the coating comprises a coating base material and a specific insoluble auxiliary material, and wherein the preparation exhibits, with respect to the active ingredient, a specific dissolution rate, as measured by the dissolution test. By using the oral sustained-release preparation of the present invention, it becomes possible to surely control the release of fasudil hydrochloride from the preparation, so that the effect of the active ingredient is maintained for a long period of time. Therefore, the burden of the patient who has to take the preparation can be decreased and the compliance with respect to the administration of the preparation can be improved. Also disclosed is a method for evaluating an oral sustained-release preparation containing the active ingredient, wherein the evaluation is conducted with respect to the sustained-release ability of the active ingredient.

1. Field of the Invention
The present invention relates to an oral sustained-release preparation. More particularly, the present invention is concerned with an oral sustained-release preparation which contains at least one active ingredient selected from the group consisting of fasudil hydrochloride and a hydrate thereof, the preparation comprising at least one sustained-release coated particle comprising a core having a surface and a coating formed on the surface of the core, wherein the core contains the active ingredient and the coating comprises a coating base material and a specific insoluble auxiliary material, the preparation exhibiting a specific dissolution rate with respect to the active ingredient, as measured by the dissolution test. The present invention is also concerned with a method for evaluating an oral sustained-release preparation containing the active ingredient, the evaluation being conducted with respect to the sustained-release ability of the active ingredient.
By using the oral sustained-release preparation of the present invention, it becomes possible to surely control the release of fasudil hydrochloride from the preparation, so that a desired amount of fasudil hydrochloride is continued to be released from the preparation for a long period of time, and that the effect of fasudil hydrochloride is maintained for a relatively long period of time. Therefore, the frequency of the administration of the preparation becomes low, so that the burden of the patient who has to take the preparation can be decreased and the compliance with respect to the administration of the preparation can be improved. As a result, the therapeutic effect of fasudil hydrochloride is rendered reliable. Therefore, the oral sustained-release preparation of the present invention is extremely useful.
2. Prior Art
1-(5-Isdquinolinesulfonyl)homopiperazine hydrochloride (hereinbelow referred to as "fasudil hydrochloride") has excellent vasodilative activity and is clinically used for treating cerebral vasospasm (which is likely to occur after the operation of a patient suffering from subarachnoid hemorrhage), cerebral ischemic symptoms accompanying the cerebral vasospasm, and the like, wherein the above-mentioned fasudil hydrochloride is used in the form of a parenteral preparation which is available under tradename "Eril Inj." (registered trademark for the product produced and sold by Asahi Kasei Kogyo Kabushiki Kaisha, Japan) (see Unexamined Japanese Patent Application Laid-Open Specification No. 5-3851 (corresponding to U.S. Pat. No. 4,678,783)).
There are two conventionally known different types of crystals of fasudil hydrochloride, i.e., crystals containing no water of crystallization (hereinbelow referred to as "fasudil hydrochloride anhydride") and crystals containing water of crystallization (hereinbelow referred to as "fasudil hydrochloride hydrate") (see International Patent Application Publication No. WO97/02260 (corresponding to EP 0 870 767 A1)).

This patent is subject to a terminal disclaimer.

Process for producing an oral sustained-release preparation of fasudil hydrochloride


A new and distinct cultivar of Veronica plant named ‘Balskywlue’, characterized by its medium violet-blue colored flowers, dark green-colored foliage, and moderately vigorous, compact, upright growth habit, is disclosed.

The present invention relates to a new and distinct cultivar of Veronica plant botanically known as Veronica hybrid and hereinafter referred to by the cultivar name 'Balskywlue'.
The new cultivar originated in a controlled breeding program in Cochranville, Pa., during December 2015. The objective of the breeding program was the development of Veronica cultivars that have attractive colored inflorescences, strong stems, and a compact, upright growth habit.
The new Veronica cultivar was the result of open-pollination. The female (seed) parent of the new cultivar is MOODY BLUES Pink 'Novaverpin', U.S. Plant Pat. No. 25,748, characterized by its light pink-colored flowers, dark green-colored foliage, and moderately vigorous, dense compact, mounded growth habit. The male (pollen) parent of the new cultivar is unknown. The new cultivar was discovered and selected as a single flowering plant within the progeny of the above stated open-pollination during August 2017 in a controlled environment in Cochranville, Pa.
Asexual reproduction of the new cultivar by terminal stem cuttings since August 2017 in Cochranville, Pa. and Elburn, Ill. has demonstrated that the new cultivar reproduces true to type with all of the characteristics, as herein described, firmly fixed and retained through successive generations of such asexual propagation.


Described is a revert preview mechanism, which gives the user a chance to temporarily remount a storage volume with the contents of a shadow copy, and then evaluate the computer system as if reverted, including allowing full I/O read and write operations to the storage volume. A temporary storage location is provided to cache data writes. Read requests are read back from the temporary storage location if the corresponding volume location has been written, or are read back from the shadow copy of the volume if not written since the revert preview operation began. In the case of a revert preview of the boot volume, an API is used to specify a correct shadow copy instance of the system registry hive, which needs to be loaded following reboot, but before the shadow copy driver is loaded. Use of the API loads the correct instance on the next reboot.

In contemporary computing, there are many reasons that a storage volume, which may be the machine's boot volume, may be exhibiting undesirable behavior. For example, as application programs, software components, driver components and so on continue to increase in complexity, problems may result from improper interactions between two or more software programs and/or components that do not work well together. In other situations, files may become corrupted, and there may be a complex collection of corrupted files. Still further, there may be one or more files stored on a storage volume that are infected with a computer virus, causing problems.
One way to solve file-related computer problems is to essentially go back in time and restore the storage volume to a state in which the computer system was operating properly. For example, a shadow copy, or snapshot, is essentially a logical copy of the information stored on a volume at a particular instant in time. To restore to the previous state, the entire volume need not be copied, but instead, changes are persisted from various snapshot points forward, in a way that does not allow new data to overwrite the snapshotted data, whereby the shadow copy can be recreated from the former data. U.S. Pat. No. 6,651,075, assigned to the assignee of the present invention and hereby incorporated by reference, describes one such shadowing mechanism, in which allocation units stored in one or more differential files and the base volume are located, in order and as needed, to recreate an earlier volume at a particular snapshot time.
Shadow copies of a volume are read-only, and allow a user to select one for viewing a volume state as it was at a corresponding snapshot time. In the event that a user locates a particular shadow copy volume to which the user wants to permanently return, such as a shadow copy that solves a volume-related problem (e.g., the most recent shadow copy that was made prior to copying or installing some file or set of files that caused the problem), the user may choose to permanently change the state of the volume back to the state of a selected shadow copy. This operation essentially allows a user to start over from an earlier state of the volume, and is referred to as a "revert" operation.
However, performing a revert operation can be a lengthy procedure. Moreover, many revert providers do not provide "undo" revert capabilities, as doing so undesirably consumes a great deal of free disk space, (assuming enough free disk space is even available for a revert undo). As a result, a user that may want to perform a revert operation has to prepare to wait a possibly significant amount of time, and has to risk permanently losing the current volume's contents, as well as risk permanently losing any shadow copies that are more recent than the one to which the user is reverting.
What is needed is a system and method that lets the user evaluate the consequences of a revert operation without committing to a full revert operation, yet do so in a manner that does not consume significant amounts of free disk space. The system and method should be relatively fast compared to a full revert operation.

Method and system of previewing a volume revert operation


Rotary spinning processes, more particularly processes for making hydroxyl polymer-containing fibers using a rotary spinning die, hydroxyl polymer-containing fibers made by the processes and webs made with the hydroxyl polymer-containing fibers are provided.

Non-rotary spinning processes for making fibers such as those using knife-edge dies and/or spunbond dies and/or melt blown dies are known in the art.
Rotary spinning processes for making fibers that do not contain hydroxyl polymers are also known in the art. For example it is known that fiberglass material fibers can be formed by rotary spinning processes. However, the prior art fails to teach or suggest rotary spinning processes for making hydroxyl polymer-containing fibers, especially hydroxyl polymer-containing fibers that exhibit wet strength properties and/or solubility properties that are suitable for consumer products.
Accordingly, there is a need for rotary spinning processes for making hydroxyl polymer-containing fibers.

Rotary spinning processes for forming hydroxyl polymer-containing fibers


Methods of treating a host suffering from restenosis are provided. The methods include delivery of a stent coated with a hypoestoxide, hypoestoxide derivative or hypoestoxide agonist compound to a vessel. The methods further include the administration of a chemotherapeutic agent in combination with delivery of a stent coated with a hypoestoxide, hypoestoxide derivative or hypoestoxide agonist compound to a vessel. The chemotherapeutic agent may be coated on the stent or administered systemically.

Coronary artery disease (CAD) is a disease that affects the blood vessels that nourish the heart muscle. CAD is a result of atherosclerosis, a build-up of fatty substances on the inner walls of the coronary arteries. When the coronary arteries become clogged or narrowed by these waxy "fats", blood flow is restricted and the heart muscle does not receive adequate oxygen, which can lead to heart attack and even death. In many cases, angina pectoris (chest pain) may occur when the heart is not receiving enough oxygen. The risk of CAD increases with elevated levels of total cholesterol and low-density lipoprotein (LDL) in the blood, but decreases when high-density lipoprotein (HDL) increases. In the United States, cardiovascular diseases are the leading cause of death in both genders, accounting for about one-third of deaths each year; the American Heart Association estimates that more than 12 million people have some form of CAD history. (American Heart Association, Fighting Heart Disease and Stroke, 2000, Heart and Stroke Statistical Update, p.5)
The problem of atherosclerosis may extend beyond the heart. Patients with CAD may also have atherosclerosis of the arterial beds including peripheral artery occlusive disease (PAOD), renal artery stenosis (RAS) and cerebrovascular disease (CBVD). This comorbidity results in an increased risk for stroke, myorcardial infarction (MI), cardiovascular death, and renal failure.
Vessels that are narrowed due to atherosclerosis are said to have undergone stenosis. The term "restenosis" refers to a re-narrowing of a vessel after a procedure has been performed to reduce a previous narrowing.
Percutaneous transluminal coronary angioplasty (PTCA) is the procedure generally used to open an obstructed artery. The placement of a balloon expanded stent or a self-expandable stent during PTCA is the leading minimally invasive treatment option. Stents are used in the treatment of new lesions or blockages, and in areas where restenosis has occurred.
A major limitation of PTCA is the problem of post-PTCA closure of the vessel, both immediately after PTCA (acute occlusion) and in the long term (restenosis). Restenosis after angioplasty is a more gradual process and involves initial formation of a subcritical thrombosis with release from adherent platelets of cell derived growth factors, along with subsequent proliferation of intimal smooth muscle cells and local infiltration of inflammatory cells contributing to vascular hyperplasia. It is important to note that multiple processes, including thrombosis, cell proliferation, cell migration and inflammation each seem to contribute to the restenotic process, and that many of these same processes contribute to the initial process of stenosis. Thus, anti-inflammatory and antiproliferative drugs, coated on stents, appear to be the most promising approach to treat various aspects of stenosis and restenosis (Hong, MK, et al., Paclitaxel-coated Gianturco-Roubin® II (GRII) stents reduce neointimal hyperplasia in a porcine coronary in-stent restenosis model, Coronary Artery Disease, 2001, Vol. 12, No. 6, pp. 513-515).
Numerous agents have been examined for presumed antiproliferative actions in restenosis and have shown some activity in experimental animal models. Some of the agents which have been shown to successfully reduce the extent of intimal hyperplasia in animal models include: heparin and heparin fragments (Clowes, A. and Kamovsky, M, Nature, 1977, Vol. 265, pp. 25-26), colchicine (Currier, J., et al., Circulation, 1989, Vol. 80, pp. 11-66), taxol (Sollott, S., et al., J. Clin. Invest., 1995, Vol. 95, pp. 1869-1876), cyclosporin A (Jonasson, L, et al., Proc. Natl. Acad. Sci., 1988, Vol. 85, p. 2303) and rapamycin (Marx, S., et al., Circ. Res., 1995, Vol. 76, pp. 412-417). Post-angioplasty restenosis is a multifactorial process that involves numerous interactive mechanisms. This means that effective prevention of restenosis may not be feasible with agents possessing a single mechanism of action. Accordingly, there is a need for multi-faceted approaches to the treatment and prevention of restenosis following PTCA

Hypoestoxides, derivatives and agonists thereof for use as stent-coating agents


A standard sample composition containing a complexing agent and an alkali salt, mixed with a known amount of a foodstuff, the content of at least one component of which is accurately known. The mixture is dissolved in a solvent, e.g. water, and comminuted to form a dispersion. The solvent is removed e.g. by freeze-drying or other suitable method, such that the water content of the composition is <5% by weight, preferably <1% by weight, more preferably <0.1%, most preferably <0.01% by weight of the total composition.

In my own European Patent Application EP 0 962 768 (corresponding to Swedish patent application SE-9801827-8), incorporated herein in its entirety by reference, there is disclosed and claimed a product suitable for dispersing foodstuff for analytical purposes. The object of the invention claimed therein is to prepare samples that are possible to analyze with as few errors and artifacts in the analysis results as possible.
The product claimed in EP 0 962 768 comprises a composition of a complexing agent, e.g. emulsifying salts and an alkali salt. The product is dissolved in water and the foodstuff to be analyzed is mixed with the solution, and the mixture is milled in a suitable mill. A homogeneous dispersion in liquid form results, having a milk-like appearance. This dispersion is then readily analyzed by common methods, such as mid-infrared (MIR) spectroscopy, UV spectroscopy or chemical extraction methods, to mention some.
A problem in all analyses of complex compounds or material is to be sure that the analytical results are accurate. The accuracy and precision of different analysis methods have to be validated frequently with (standard) reference samples and/or in collaborative studies. For inorganic compounds there are standard samples available. For organic compounds like fat, protein, carbohydrate in different foodstuffs, long-life standard samples are not so common as in general, it is more complicated to store the foodstuffs or samples without any deterioration of the different compounds. In the food industry for analytical purposes the validation of different methods are mainly controlled and calibrated by analysing the control or calibration samples with the routine method as well as with some reference chemical methods. The chemical methods are often time-consuming and complicated and therefore expensive. In most cases the samples are sent to a reference laboratory. It can take some days or weeks to obtain an answer, but usually the routine laboratory needs the results immediately.
Therefore, there is a great demand of long-life standard samples of different foodstuffs in the food and feed laboratories, so the different methods can be controlled and calibrated immediately.

Standard sample composition and manufacture thereof


Gesture input with multiple displays, views, and physics is described. In one example, a method includes generating a three dimensional space having a plurality of objects in different positions relative to a user and a virtual object to be manipulated by the user, presenting, on a display, a displayed area having at least a portion of the plurality of different objects, detecting an air gesture of the user against the virtual object, the virtual object being outside the displayed area, generating a trajectory of the virtual object in the three-dimensional space based on the air gesture, the trajectory including interactions with objects of the plurality of objects in the three-dimensional space, and presenting a portion of the generated trajectory on the displayed area.

Computer system inputs have developed to include air gestures and touch screen gestures as inputs. Air gestures can involve users moving their body and having a corresponding action happen on a display or having a corresponding command be executed by the computing system. One form of current air gesture technology uses movable sensors either as a controller or as the game console. The sensors are held in the hand, attached to the body, or manipulated by hands, feet, or other parts of the body (such as in the Wii remote controller by Nintendo Company, PlayStation Move by Sony Corporation, and various smartphones, and handheld gaming devices). Another form of air gesture technology uses 3D camera and microphone technology (such as in the Microsoft Kinect by Microsoft Corporation and PlayStation Eye by Sony Corporation) to approximate body motion as a modal input source.
Television, computer, and portable device displays are typical feedback mechanisms for viewing the effects of air-gesture modal input on a graphical environment. Cameras gather video input for gesture detection, and the video input is interpreted with software that runs on a gaming console or a personal computer. A camera array allows the cameras to sense depth. This provides the ability to recognize the position or distance of a person's body is in relation to the camera. The camera array allows for additional air gestures that move towards and away from the camera.
As another form of gestures, the screens of gaming consoles and computers, such as desktop, notebooks, tablets and smartphones, incorporate touch-screen technology which responds to touch input. Touch and sweep gestures on a display screen are used as a user input to execute commands to move objects from one screen (e.g. a handheld console screen) to another screen (e.g. a TV screen). Such features are implemented, for example, when using the PlayStation Portable game console together with a Play Station 3 console both marketed by the Sony Corporation. Touch and sweep gestures are also offered on trackpads of notebook computers and as surfaces on a peripheral mouse or external track pad.

Gesture input with multiple views, displays and physics


The invention concerns an iron-based powder for powder-metallurgically producing components by powder compacting and sintering. The powder contains 0.25-2.0% by weight of Mo, 1.2-3.5% by weight of Mn, 0.5-1.75% by weight of Si and 0.2-1.0% by weight of C and not more than 2% by weight of impurities including less than 0.25% by weight of Cu. The invention also includes a method for preparing sintered components from this iron powder, as well as the sintered products.

Nickel is a relatively common alloying element in iron-based powder compositions in the field of powder metallurgy, and it is generally known that nickel improves the tensile strength of the sintered components which have been made by iron powders containing up to 8% of nickel. Additionally, nickel promotes sintering, increases the hardenability and has a positive influence on the elongation at the same time.
A currently marketed powder, the use of which results in products having properties similar to those obtained with the product according to the present invention, is Distaloy.RTM.AE, which contains 4% by weight nickel.
There is however an increasing demand for powders which do not contain nickel as, for instance, nickel is expensive, creates dusting problems during the processing of the powder, and causes allergic reactions in minor amounts. From an environmental point of view the use of nickel should thus be avoided.

Manganese containing materials having high tensile strength


An organic light emitting device includes a substrate and an organic compound layer sandwiched between a pair of electrodes composed of an anode and a cathode. The organic compound layer includes at least two active layers. A melting point of each of the two active layers gradually decreases along a direction from the anode to the cathode.

An organic light emitting device generally includes an emissive electroluminescent layer which is a film of organic compound layer that emits light in response to an electric current. The organic compound layer is situated between a pair of electrodes which respectively are an anode and a cathode. In particular, the organic light emitting device can significantly reduce applied voltage, can be easily downsized, requires small power consumption, enables surface emission, and facilitates light emission of three primary colors. Therefore, research for putting the organic light-emitting devices into practical use as new-generation light-emitting devices has been vigorously conducted. In a typical organic light emitting device, the organic compound layer can be manufactured by injecting liquid materials such as using an inkjet device to form an organic film on a substrate. However, the organic film may suffer from thickness mura due to the surface tension of the liquid materials.

Organic light emitting device and method of manufacturing the same


The invention relates to a nucleotide sequence, which is able to inhibit the IL-6 activity, its use in therapy as well as pharmaceutical compositions containing it.. In particular, it relates to a nucleotide sequence which comprises:. i) at least one nucleotide sequence that is an APRE element of general formula ZXMYKGKAA, wherein Z represents T or G or can also be absent, X represents T or can also be absent, M represents C or A, Y represents C or T and K represents T or G, PA1 ii) at least one nucleotide sequence constituting a transcription factor binding site other than the APRE element, such as those present in promoter regions.. in conjunction with

IL-6 is a protein belonging to the group of cytokines, which proved to play a key role in the organism's immune response and haematopoiesis stimulation.
Many biological functions have, in fact, been found for IL-6 in the hematopoietic and lymphoid system, in the liver and in other target organs and cells. Some of these functions are beneficial, while others are related to pathological states. Among the latter functions, IL-6 has been found to be a growth factor for multiple myeloma cells; anti-IL-6 antibodies were shown to transiently block myeloma cell proliferation in a leukemic patient (see for example Klein et al., Blood, 78, (5), pp.1198-1204, 1991 and Lu et al., Eur. J. Immunol., 22, pp. 2819-24, 1992).
Elevated IL-6 levels have been correlated with autoimmune and inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, psoriasis, and Castelman's disease (see for example Graeve et al., Clin. Investig., 71, pp.664-71, 1993). IL-6 has also been shown to play a direct role in bone loss and hypercalcemia (see for example Poli et al., Embo J., 13, (5) pp. 1189-96 and Yoneda et al., Cancer Res., 53, pp. 737-40, February 1993).
The development of inhibitors of IL-6 activity has therefore been the subject of active research. For this purpose, different approaches have been pursued, including the use of antibodies against IL-6 (as reported by Klein et al. above), gp130 or gp80; the use of soluble gp130; or the use of muteins for IL-6, or IL-6 Receptor.
Since these approaches might be associated with specific unwanted effects in clinical applications (as reported by Lu et al., above), the setting-up of additional strategies to inhibit IL-6 activity would be useful.
The Applicant has, therefore, investigated a different approach to inhibit IL-6 activity: by blocking the intracellular proteins mediating the IL-6 signal.
The transduction of the IL-6 signal in responsive cells has been intensively investigated. Fowlkes et al. (PNAS USA, 81, pp. 2313-6, 1984) first suspected DNA responsive elements specific for IL-6 flanking the rat fibrinogen genes.
Later on, Kunz et al. (Nuc. Ac. Res., 17, (3), 1121-37, 1989) showed a responsive element with a core sequence identical to that of rat fibrinogen genes (CTGGGA) to respond to IL-6 in the rat .alpha..sub.2 -macroglobulin gene.
DNA responsive elements with sequences related to those above-mentioned have also been defined in the genes coding for the human C Reactive Protein (CRP) (see Toniatti et al., Mol. Biol. Med, 7, pp. 199-212, 1990), human haptoglobin (see Oliviero et al., Embo J. 6, (7), pp. 1905-12, 1987) and in other genes coding for additional acute phase proteins induced by IL-6 (see Heinrich et al., Biochem. J., 265, pp. 621-36, 1990), leading to the definition of a core consensus sequence CTGGGAW or CTGGRAA, where W stands for A or T, and R stands for A or G.
Hocke et al. (Mol. Cell. Biol., 12, (5), pp. 2282-94, 1992) indicated that multiple related core sequences, similar to the core sequence mentioned above, might be present in regulatory regions of wild-type genes responding to IL-6 and that this multiplicity leads to amplification of the response, as functionally analyzed with a reporter gene assay.
Wegenka et al. (Mol. Cell. Biol., 13, (1), pp. 276-88, 1993) have recently indicated an enlarged version of the core consensus sequence as the Acute Phase Response Element (APRE), active in hepatoma cells that can be represented by the formula KTMYKGKAA, wherein M stands for C or A, K stands for T or G, Y stands for C or T.
By Yuan et al. (Mol. Cell. Biol., 14, (3), pp. 1657-68, 1994) it has been shown that such APRE-like sequences bind a protein transcription factor having a molecular weight of about 90 KD, called APRF which has been recently cloned (see Akira et al., Cell, 77, pp. 63-71, 1994). In practice, the binding of activated APRF to APRE sequences would therefore lead to activation of IL-6-inducible genes (containing such APRE sequences) in IL-6-responsive cells.
As a consequence of this, an APRE element can be used as enhancer of a target gene in IL-6 responsive cells in the following way: in IL-6 responsive cells, the treatment with IL-6 induces the synthesis of APRF proteins, which bind to the APRE element, and such binding activates the expression of the target gene.
Serlupi Crescenzi et al. (Poster at the 12th European Imunol., Meeting, Barcelona, Jun. 14-17, 1994) have shown that an 8-fold repetition of the APRE DNA sequence (M8) is responsible for a 50-100 fold induction by IL-6 of a reporter gene in HepG2 human hepatoma cells.

Applied Research Systems ARS Holding N.V.


A user interface technique with excellent operability for displaying an object to be selected upright for an operator who operates a display screen of a display device from any direction. For this purpose, when the operator touches the display screen with his/her index finger, menu icons are displayed on a circumference with the touch position as a center, and with the central position of the circle as a lower position, at equal intervals. At this time, when the operator touches the display screen with his/her thumb while touching the display screen with his/her index finger, it is determined that the operator exists on an extension line on the thumb touch position side defined with the two touch positions. Then the respective menu icons are rearranged so as to be displayed upright from the operator.

1. Field of the Invention
The present invention relates to a menu display technique accompanying coordinate detection.
2. Description of the Related Art
Conventionally, a drawing tool and the like having a function of arraying objects arranged by a user on contents are known. Generally, when plural objects are arrayed, first, the user drags a mouse to select plural objects, then clicks the right mouse button to open a menu for arrangement. Then, among the menu items, the user selects a desired type of arrangement style.
Further, an interactive display in which an operation is performed by an operator's directly touching its screen is known. This interactive display is realized by integrating a display device and a touch panel as a position detecting device or a coordinate input device. The operator can perform display control by directly touching the display screen, thereby an intuitive operation environment like "use with paper and a pencil" is provided.
Further, as this type of touch panel or coordinate input apparatus, a device capable of detecting plural instructing positions is known.
Japanese Patent Laid-Open No. 2001-290585 discloses a technique for enlarging/reducing/rotating an object based on a change of distance between designated two points or an angular change.
Japanese Patent Laid-Open No. 2010-040029 discloses a structure having recognition means for recognizing designation of plural positions on a display unit, in which plural objects can be selected by a first designating operation. Further, the structure has alignment means for, when a second designating operation is performed in that status and when movement in the first position or the second position has been detected, aligning the plural objects on the display unit in accordance with the locus of the movement.
Further, Japanese Patent Laid-Open No. 2010-086519 discloses the action of an object selection by a first designating operation and a scroll operation by a second designating operation on other objects than the selected object.
Generally when this type of interactive display is used, it is placed upright on a desk or put on the wall. Accordingly, an operational environment can be provided to the operator without a sense of discomfort by bringing the up-and-down direction of a displayed object into correspondence with the vertical direction.
However, when the display screen is placed flat on the desk and plural operators are seated around the display screen (FIG. 7A), an operational environment convenient for one operator is not a comfortable operational environment for the opposite operator (FIG. 7B). That is, for the opposite operator, the display of the object is upside-down, and the display disturbs instantaneous understanding.

Information processing apparatus, information processing apparatus control method and storage medium


A double data rate (DDR) counter includes a clock selection unit suitable for selectively inverting a first counting clock based on a control signal and for outputting a second counting clock, a first latch stage suitable for latching the second counting clock based on a counting enable signal and for outputting the least significant bit (LSB) of the DDR counter, a determination unit suitable for generating the control signal based on the last bit state of the LSB in a reset counting period, and a second latch stage suitable for receiving the LSB as a clock input to generate a higher bit of the LSB at least in a main counting period.

1. Field
Exemplary embodiments of the present invention relate to an integrated circuit design, and more particularly, to a double data rate (DDR) counter, an analog-digital converter, and a CMOS image sensor using the same.
2. Description of the Related Art
In general, an analog-digital converter (ADC) may be used for various electronic devices to convert a valid physical parameter, such as intensity of light, intensity of sound, or time, into a digital signal.
For example, an image sensor acquires an image by using the properties of semiconductor responding to incident light, and includes an analog-digital converter to convert an analog signal outputted from a pixel array into a digital signal. The analog-digital converter includes a counter to perform a counting operation using a clock.
Meanwhile, the operating speed and power consumption of the counter have a direct effect on the performance of a device or system including the counter. In particular, a CMOS image sensor may include a plurality of counters to convert analog signals, which are outputted in the unit of column from an active pixel sensor array, into digital signals. The number of counters may be increased depending on the resolution of the CMOS image sensor. As the number of counters increases, the operating speed and power consumption of the counter may serve as an important factor to determine the entire performance of the image sensor.
Thus, a double data rate (DDR) counter is proposed to reduce the power consumption in a CMOS image sensor using a single-slope ADC. The DDR counter may realize the same resolution while reducing counter speed to the half. Furthermore, the DDR counter may apply a digital double sampling (DDS) technique to remove an offset by using output codes of a reset voltage and a signal voltage, respectively.
However, in order to implement the conventional DDR counter, the number of peripheral circuits, such as flip-flops and multiplexers, may increases. With the increase in number of the peripheral circuits, circuit complexity inevitably increases. As a result, the power consumption of the counter may be increased, and the operating speed of the counter may be reduced.

Double data rate counter, and analog-digital converting apparatus and CMOS image sensor using the same


A method of making a composite component and the composite component is disclosed. The composite component can comprise multiple portions with different materials. By configuring the composite component with different materials, the weight of the composite component can be reduced while maintaining the strength and support of the composite component for a cockpit assembly. Furthermore, the method provides for an increase in the efficiency of the die casting process used to create the composite component.

1. Field of the Invention
The present invention relates to a method of making composite components and a composite component that can be used in a motor vehicle.
2. Description of Related Art
Cockpit assemblies for a motor vehicle can include an instrument panel and a cross-beam to support the instrument panel. Often, the cross-beam can be specifically designed to support a steering column. In many cases, the cross-beam is a single die-cast beam made of a metal or metal alloy.

Method of making a composite component and apparatus


In the case where all print jobs are stored in a nonvolatile storage area such as a hard disc to protect the print job at power-off, normal printing time becomes long. In the case where a power-off request is received, the print job that is executing print processing is stored in the nonvolatile storage area. At this time, the print job and authentication information capable of identifying a print-instructing person are associated with each other and stored.

1. Field of the Invention
The present invention relates to an image forming device, an image forming method and program that protect a print job at power-off.
2. Description of the Related Art
In recent years, under the situation of power saving and power supply shortage, power consumption amount of information equipment and power supply amount to the information equipment have become controllable by a power management server. In some cases, the power management server transmits a power-off request to the information equipment, and cuts off power of the information equipment. At this time, while the information equipment is executing some processing, there may occur a problem that the processing cannot be continued. For example, in the case of receiving the power-off request during print processing, a copying machine stops the print processing and cuts off power, resulting in that a printed matter cannot be obtained. At this time, by controlling so as to cut off power after completion of the print processing, it is possible to obtain the printed matter. However, there occurs a problem that power-off cannot be immediately executed.
To solve such problem, an art on a printer server that stores print data requested by a print-requesting device is known (for example, Japanese Patent Publication No. 3344186). According to Japanese Patent Publication No. 3344186, authentication information of the print-requesting device and the print data requested by the print-requesting device are saved in a hard disc as nonvolatile storage means of the printer server. Thus, in the case where power is turned on again after cut-off of the power for the printer server, the print processing can be automatically restarted.
However, according to the above-mentioned prior art, since the print data requested by the print-requesting device is stored in the hard disc of the printer server at all times, as compared to the case where the print data is printed without being stored in hard disc, printing takes a longer time. This is due to additional time required to write the received print data from a volatile memory such as a memory into the hard disc, and time required to read the print data from the hard disc for printing.

Image forming device, image forming method and program


Techniques are presented herein for reducing network congestion in data center environments. A controller device in a network receives a registration request from a physical switch device and from a virtual switch that is hosted by a server device in the network. The controller device registers the physical switch device such that the controller device is able to send configuration messages to the physical switch device. The controller device also registers the virtual switch such that the controller device is able to receive mapping information from the virtual switch. The controller device receives from the virtual switch the mapping information comprising Media Access Control address information of one or more virtual machines that are in communication with the virtual switch. The mapping information is stored in a database maintained by the controller device.

In network environments, physical servers ("servers") may be located in a rack unit that houses a plurality of servers. The rack unit has a top of rack (ToR) switch that is configured to manage communications between the servers and other network elements within the rack unit. The servers may be configured to host one or more virtual machines that may be arranged in one or more virtual networks. Furthermore, the servers may be configured to host one or more virtual switches that are configured to manage communications to and from the virtual machines.
Large network or data center environments may comprise multiple rack units, each of which has a ToR switch, a plurality of servers, and a plurality of virtual machines and virtual switches hosted by the servers. In such topologies, a central controller device may be present to manage or direct communications between rack units. The central controller device, thus, may be in communication with the ToR switches in each rack unit to manage communications to and from the rack units in the data center environment.

Proxy address resolution protocol on a controller device


A suction-holding apparatus includes a suction plate made of an air-permeable material, a holding member formed with a through-hole in which the suction plate is placed, and a base to which the holding member is attached. The suction plate includes a jutting-out portion so that the outer edge of the rear face is disposed outwardly from the outer edge of the front face. The through-hole includes a first edge and a second edge spaced apart from each other in the thickness direction. The first edge is adjacent to the base. The holding member includes an eaved portion so that the second edge of the through-hole is disposed inwardly from the outer edge of the rear face.

1. Field of the Invention:
The present invention relates to a suction-holding apparatus and a wafer polishing apparatus.
2. Description of the Related Art:
Wafer polishing apparatuses for polishing semiconductor wafers employ e.g., a polishing device having a polishing pad. By the polishing process, it is expected that the semiconductor wafer is to have a predetermined thickness, and also have a smooth surface. To this end, it is essential to hold the semiconductor wafer securely in a flat state. An example of suction-holding apparatuses for holding a semiconductor wafer is disclosed in JP-A-No. 2000-158268.
The suction-holding apparatus of JP-A-No. 2000-158268 includes a base and a suction plate. The base includes a circular cavity, and a plurality of suction holes formed in the bottom face of the cavity. The suction holes are connected to a suction device such as a pump, so as to suck an object.
The suction plate is fitted in the cavity of the base. The suction plate is composed of a plurality of annular elements that are concentrically disposed. The annular elements include high-permeability annular elements constituted of an air-permeable material such as a porous ceramic, and low-permeability annular elements that are barely air-permeable. The high-permeability annular elements and the low-permeability annular elements are alternately located. The low-permeability annular elements are significantly smaller in radial size than the high-permeability annular elements, and serve as blocking walls that restrict permeation of air.
When the wafer polishing apparatus is used for polishing, the semiconductor wafer to be polished is mounted on the suction plate by using the suction-holding apparatus. Then the semiconductor wafer is sucked through the suction holes. At this point, a suction force is exerted on the semiconductor wafer through the high-permeability annular elements of the suction plate. The suction force allows the semiconductor wafer to be held by the suction-holding apparatus, thus to be ready to be polished. In the suction-holding apparatus, the suction holes are divided into some groups, each of which is connected to the suction device. Controlling the suction performance of each group, for example by using valves, allows only selected high-permeability annular elements to activate the suction force according to the size of the semiconductor wafer to be polished, from those having a relatively small diameter to those having a relatively large diameter.
The suction plate, including a portion made of e.g. a porous ceramic, is fixed to the base, using an adhesive, for example. Specifically, the suction plate is bonded to the bottom face of the cavity of the base. However, the suction plate is repeatedly subjected to compressive force and shear force from the polishing device, via the semiconductor wafer. Accordingly, the bonding force of the adhesive declines through repeated polishing sessions, and one or more of the plurality of annular elements of the suction plate may be separated from the base. In such a case, a minute step is formed on the surface of the suction plate, thereby preventing the semiconductor wafer from being securely held.

Suction-holding apparatus and wafer polishing apparatus


A sanitary outlet fitting (1) having a water outlet (2) with an internally threaded receiving opening (3) is provided, having a sleeve-shaped outlet nozzle (7) which has an external thread on its periphery which can be screwed in a releasable manner into the internal thread of the receiving opening, and having a jet regulator or similar sanitary insert part that is retained in the sleeve interior of the outlet nozzle. The outlet nozzle (7) includes on its outlet end side, at least one slot, a profiling or a similar tool attachment surface, and a ring element (5) is mounted in a freely rotatable manner at the outlet end region of the outlet nozzle (7) that encloses the outlet nozzle and serves for vandal proofing. The outlet fitting (1) according to the invention is characterized in that the internal diameter (d1) of the receiving opening (3) at the outer end region of the fitting corresponds, at least approximately, to the external diameter (d2) of the outlet nozzle (7) in the region of the freely rotatably mounted ring element (5), and the axial depth (l1) of the receiving opening (3) is adapted to the axial extension (l2) of the outlet nozzle (7) such that the outlet nozzle (7) only has part of the longitudinal extension of the ring element (5) projecting beyond the receiving opening (3).

The invention relates to a sanitary outlet fitting with a water outlet, provided with an receiving opening having an internal thread, with a sleeve-like outlet nozzle carrying at the perimeter an external thread that can be screwed into the internal thread of the receiving opening in a detachable manner, and with a jet regulator or a similar sanitary insert part held inside the sleeve of the outlet nozzle with the outlet nozzle carrying at the face of its outlet end at least a slot, a profiling, or a similar tool attachment surface and with a ring element being supported in a freely rotational manner at the outlet end region of the outlet nozzle, encompassing the outlet nozzle and serving as a vandalism protection.
The jet regulators inserted in outlet fittings form the out flowing water to a homogenous, bubbling-soft water jet. In order to allow fastening such a jet regulator or at least another sanitary insert part to such a sanitary outlet fittings, some sanitary outlet fittings with a water outlet are already known, which include outlet openings having an internal thread, and a sleeve-like outlet nozzle, which circumferentially carries an external thread that can be screwed in a detachable manner into the internal thread of the outlet opening, with the jet regulator or a similar sanitary insert part being held inside the sleeve of the outlet nozzle. Frequently there is the problem, though, that the jet regulator or similar sanitary insert part, held via a sleeve-shaped outlet nozzle to a sanitary outlet fitting, is screwed out of the outlet fitting and stolen by unauthorized persons, in particular when it is used in the public sector, for example in hotels, restaurants, or athletic facilities.
In order to prevent such theft, sanitary outlet fittings of the type mentioned at the outset are known, with their outlet nozzle carrying a slot, a profiling, or a similar tool attachment surface at the face of its outlet end, with a ring element encompassing the outlet nozzle supported in a freely rotational manner at the outlet end region of the outlet nozzle, serving as a vandalism protection. In this manner, the outlet nozzle and the sanitary insert part located therein cannot be screwed out of the sanitary outlet fitting by unauthorized persons, because when turning the ring element, the outlet nozzle itself does not rotate. In order to assemble or disassemble the outlet nozzle as well as the sanitary insert part located therein, a special tool is necessary, which is inserted into the outlet nozzle at the downstream end and thus allows the external thread provided at the outlet nozzle to be screwed in or screwed out of the internal thread of the water outlet fitting.
In these outlet fittings of prior art it is disadvantageous, though, that the ring element freely rotational at the outlet nozzle has an additional, relatively large diameter so that the ring element protrudes entirely beyond the water outlet of the sanitary outlet fitting and the outlet fitting thus has an unappealing appearance. Additionally, in outlet fittings with a curved water outlet a sectionally ugly gap develops between the water outlet of the sanitary outlet fitting, on the one hand, and the ring element of the outlet nozzle, on the other hand, so that the cleaning in this area is also more difficult. Additionally, based on its relatively large diameter in particular in curved outlet fittings, the freely rotational ring element can abut the outlet fitting such that the outlet nozzle cannot entirely be screwed into internal thread of the outlet fitting and the ring seal provided at the threaded face of the jet regulator cannot fulfill its sealing function.
From U.S. Pat. No. 2,989,249 A, a sanitary outlet fitting with a water outlet is known, that includes a receiving opening with internal threads. This known outlet fitting has a sleeve shaped outlet nozzle that has external threads on its periphery that engage the internal threads of the receiving opening. In the inside of the sleeve is a flow regulator or similar or similar sanitary insert part. The outlet nozzle carries on its outlet facing side through interchanging upward and downward projections, a crown shaped tool engageable surface. A longitudinally fixed, but freely rotatable about the longitudinal axis of the outlet nozzle, ring element is located on the thread free section of the outlet nozzle that extends from the outlet mouth that does not have a gripping surface to prevent unauthorized unthreading of the outlet nozzle. Similar protection from unauthorized manipulation of sanitary outlet fixtures is also provided in U.S. Pat. No. 4,364,523 as well as U.S. Pat. No. 3,827,636.
For these previously known sanitary outlet fixtures, the freely rotatable ring element that extends from the water outlet on an extended area of the outlet nozzle disrupts the aesthetic appearance of the sanitary outlet fixture.

Sanitary outlet fitting with vandal-proof outlet nozzle recessed in the accommodating opening of the fitting


An apparatus and method for obtaining fiber weight measurements in the wet end of a sheetmaking system and for verifying fiber weight measurements taken in the wet end of a sheetmaking system which includes a water weight sensor positioned beneath the wire in the wet end of the sheetmaking system for obtaining water weight measurements and load cells residing beneath the water weight sensor for weighing the wet end sensor and the wire with wetstock (total weight) and without wetstock (tare weight). In one embodiment, the water weight measurement and the tare weight measurement are subtracted from the total weight to obtain the fiber weight in the wetstock. In another embodiment, the water weight measurement is used to obtain an predicted fiber weight measurement and the determined fiber weight is used to verify the predicted fiber weight measurement and the accuracy of the water weight measurement device.

1. Field of The Invention
The present invention relates to measuring fiber weight in a continuous sheetmaking machine process, and more particularly, to a sensor for monitoring fiber weight on the wire of a sheetmaking machine.
2. State of The Art
In the manufacture of paper using a continuous sheetmaking machine, a web of paper is formed from an aqueous suspension of fibers (stock). Stock is dispersed from a dispensing unit referred to as a headbox onto a traveling mesh wire or fabric and water drains by gravity and vacuum suction through the fabric. The web is then transferred to the pressing section where more water is removed by dry felt and pressure. The web next enters the dry section where steam heated dryers complete the drying process. The sheetmaking machine is essentially a de-watering, i.e., water removal system. In the sheetmaking art, the term machine direction (MD) refers to the direction that the sheet material travels during the manufacturing process, while the term cross direction (CD) refers to the direction across the width of the sheet which is perpendicular to the machine direction. Furthermore, in general, the elements of the system including the headbox, the web, and those sections just before the dryer are referred to as the "wet end". The "dry end" generally includes the sections downstream from the dryer. Papermaking elements and machines are well known in the art and are described, for example, in "Handbook for Pulp & Paper Technologists" 2nd ed., G. A. Smook, 1992, Angus Wilde Publications, Inc., and "Pulp and Paper Manufacture" Vol III (Papermaking and Paperboard Making), R. MacDonald, ed. 1970, McGraw Hill. Sheetmaking machines are further described, for example, in U.S. Pat. Nos. 5,539,634, 5,022,966 4,982,334, 4,786,817, and 4,767,935.
In the art of making paper, sheet properties (such as sheet strength, thickness, and weight) are continually monitored and the sheetmaking machine controlled and adjusted to assure sheet quality and to minimize the amount of finished product that is rejected. This control is performed by measuring sheet properties at various stages in the manufacturing process which most often include basis weight, moisture content, and caliper (i.e., thickness) of the sheet.
Typically, a scanning sensor is used to perform basis weight measurements of the finished sheet at the dry end of the sheetmaking machine. Scanning sensors are known in the art and are described, for example, in U.S. Pat. Nos. 5,094,535, 4,879,471, 5,315,124, and 5,432,353. The basis weight measurements obtained from the scanner are used to control elements in the sheetmaking machine to adjust basis weight, and hence, paper quality.
There are several problems related to scanning type sensors. In particular, to date scanning sensors have been positioned at or in close proximity to the dry end of the sheetmaking machine. One reason for this is that the scanning measurement equipment cannot tolerate the harsh conditions within the wet end of the sheetmaking machine. Since the scanning sensors are located near the end of the paper making process, process variations occurring at the beginning of the sheetmaking machine in the wet end (i.e., on the wire) are not detected until the final paper is scanned at the dry end. As a result, any paper produced within that time period will potentially have degraded quality. Additionally, since scanning sensors obtain fiber or basis weight measurement readings as the sheet travels along the machine, the actual sensor measurements are taken on a diagonal path. As a result, the measurement readings obtained from a scanning sensor are inter-related machine direction (MD) and cross direction (CD) weight readings. In order to decouple the cross and machine direction weight information, the scanned data is often averaged and processed along with other scanned data readings to obtain an approximation of the MD and CD weight measurements of the paper. This processing also takes time, thereby adding to the overall delay in obtaining feedback data for monitoring process variation and adjusting the sheetmaking machine.
What would be desirable is to obtain fiber weight readings closer to the beginning of the sheetmaking process in a reliable manner.

Weight measurement and measurement standardization sensor


Data can be protected in a centralized tokenization environment. A request to tokenize sensitive data is received by an endpoint. A token for use in tokenizing the sensitive data is identified. A token certificate store is queried for a token certificate associated with the identified token. The token certificate can include a token status and use rules describing a permitted use of the token. Responsive to the token certificate store storing the queried token certificate, the endpoint tokenizes the sensitive data using the identified token if the token status indicates the token is available, and subject to the use rules included in the token certificate being satisfied. The token certificate is updated based on the tokenization of the sensitive data with the identified token and stored at the token certificate store.

Many challenges exist in handling financial and other sensitive data, such as credit card numbers, social security numbers, bank account numbers, and the like. To prevent unauthorized access to sensitive data, steps can be taken to protect the sensitive data. Such data protection measures are required by many jurisdictions for various categories of sensitive data. The sensitive data can be encrypted during transmission or storage using an encryption algorithm and encryption key. However, encryption can be overcome/broken using a variety of hacking methods, and the use of encryption in financial systems is often subject to resource-intensive audit requirements. Data storage security measures can be implemented while the sensitive data is stored at an authorized entity, but such storage security measures generally protect against intrusion by an unauthorized entity and do not protect the sensitive data after the unauthorized entity has overridden or bypassed the storage security measures.

Tokenization in a centralized tokenization environment


A data analysis system receives potentially undesirable electronic communications and automatically groups them in computationally-efficient data clusters, automatically analyze those data clusters, automatically tags and groups those data clusters, and provides results of the automated analysis and grouping in an optimized way to an analyst. The automated analysis of the data clusters may include an automated application of various criteria or rules so as to generate an ordered display of the groups of related data clusters such that the analyst may quickly and efficiently evaluate the groups of data clusters. In particular, the groups of data clusters may be dynamically re-grouped and/or filtered in an interactive user interface so as to enable an analyst to quickly navigate among information associated with various groups of data clusters and efficiently evaluate those data clusters.

Embodiments of the present disclosure generally relate to identifying phishing, spam, and malicious electronic communications.
Phishing communications are unsolicited electronic communications, from fraudulent senders masquerading as trustworthy entities, seeking sensitive information from recipients of the unsolicited electronic communications. Spam communications are unsolicited bulk communications akin to electronic junk mail. Malicious communications include unsolicited communications sent with the intention of disrupting the recipient's computer or network communications intended to install "malware" (hostile or intrusive software, in the form of executable code, scripts, active content, and other software, which includes computer viruses, worms, Trojan horses, ransomware, spyware, adware, scareware, and other malicious programs). It is important for local network administrators to identify such communications and take appropriate actions to protect the local network or the recipients' computers or sensitive information. In this disclosure, the term "undesirable electronic communications" or "undesirable communications" encompasses, among other things, phishing, spam, and other malicious electronic communications, including those discussed above and others described herein.

Systems, methods, user interfaces, and computer-readable media for investigating potential malicious communications


In accordance with the present invention, a WDM communication signal including a service channel is received by an add/drop multiplexer. An optical filter element included in the multiplexer separates a first optical payload channel and the service channel from the WDM signal and outputs these signals on a first output port. The remaining WDM channels exit the optical filter at a second output. By utilizing this add/drop multiplexer to select both an optical channel and a service channel, the total power loss associated with a communications network is significantly less than that obtained from networks having separate components to add/drop an optical payload channel and a service channel.

Wavelength Division Multiplexing (WDM) is used to transmit a plurality of optical channels via an optical waveguide medium where each channel carries information signals within a network or system. Each channel within the WDM signal is associated with a particular wavelength, thereby increasing the information capacity of fiber optic systems. Such optical systems include, for example, local area networks (LANs), telecommunication systems and cable television systems. Depending on the optical system configuration and the transmission path, various optical and/or electrical amplifiers are required to provide the necessary optical power to efficiently transmit and amplify the WDM signal to each component within the network.
WDM optical networks have traditionally been used for long haul point to point networks. However, with the increasing demands on communication systems, WDM optical networks can also be used in smaller system configurations, such as local telephone or data networks. In these systems, communication signals are usually transmitted over a limited geographic area to various nodes within a network. A particular node can be configured to drop one or more information bearing or payload channels from the WDM signal, process the information contained in the dropped channels and add the channels containing new information to the WDM signal for transmission to other nodes in the network. An optical multiplexer present at each node may be used to drop the particular channel from the WDM signal and subsequently add the channel back to the WDM signal prior to transmission to another network node.
Because the transmission distance between nodes in these types of networks is relatively small, optical amplifiers are avoided in order to reduce the cost of the network. However, each optical component introduces optical power loss, measured in dBs. For example, the use of a fused fiber optical coupler may contribute a 3 dB loss to the transmission signal. This loss can accumulate among the various network components, but cannot exceed a predetermined power loss budget associated with the network configuration.
A service channel, usually outside the information bearing or payload channel bandwidth, is preferably included in these optical systems for carrying system housekeeping information, for example network monitoring and control signals as well as telemetry information, to and/or from nodes in the network. Because the service channel wavelength is outside the payload channel bandwidth, separate components configured to receive and process the service channel are required. These service channel specific components increase the power loss within the network unrelated to the payload channels where the extra loss is seen by the through channels passing to other network nodes. Moreover, these service channel components negatively impact the loss budget associated with the network.
Thus, there is a need to reduce the power loss associated with optical networks by combining the use of service channel components with payload channel components within an optical WDM network. There is also a need to provide these components at reduced expense.


A thermal ink jet ink composition includes one or more volatile organic solvents, wherein the one or more volatile organic solvents comprise a solvent selected from C1-C4 alcohols, C3-C6 ketones, C3-C6 esters, C4-C8 ethers, and mixtures thereof. The one or more volatile organic solvents are present in an amount at least 60% by weight of the ink composition. The ink composition includes one or more binder resins present in an amount from 1% to 10% by weight of the ink composition, and one or more dyes. If water is present, it is present in amount less than 5% by weight of the ink composition. The ink composition includes less than 2% by weight of any humectant and/or wetting agent with a relative evaporation rate less than 0.3. The ink composition is suitable for use in a thermal ink jet printer.

Thermal ink jet (TIJ) print heads produce ink droplets from thermal vaporization of the ink solvent. In the jetting process, a resistor is heated rapidly to produce a vapor bubble which subsequently ejects a droplet from the orifice. This process is extremely efficient and reproducible. Modern TIJ print heads for industrial graphics applications are capable of generating uniform drops of 4 pL volume or smaller at frequencies of up to 36 kHz or greater. Typical commercial TIJ devices are specifically designed to vaporize water or solvents that have physical properties close to those of water (e.g. high boiling point, large heat capacity, low molecular weight).
Typical TIJ printers print very well onto porous absorbent or semi-absorbent materials or some kinds of nonporous materials such as those used in controlled pharmaceutical settings. However, as these printing systems are incorporated into a wider variety of production environments, the different kinds of primary packaging materials used-particularly plastic films—require greater versatility from the inks. Also, in many packaging plants, such as food packaging, many different kinds of plastics can be used, sometime interchangeably, and plant operators must have confidence that their printing systems will adapt without the need to change ink types.
Although TIJ printing systems have been available for over 30 years, nearly all of the commercial inks available for thermal ink jet systems have been water-based, i.e. they contain more than 50% water. Such aqueous inks have one or more drawbacks such as long ink dry times or poor adhesion to semi-porous or non-porous substrates such as plastics.
There is a desire for inks with performance characteristics for printing in mass production environments such as short dry times, long decap times and good adhesion when using a TIJ system to print onto semi-porous and non-porous substrates.


Compounds of formula I ##STR1## including pharmaceutically acceptable salts thereof in which R.sub.1 represents hydrogen, 2-phenyl-1,3-dioxan-5-yl, a C.sub.1-6 alkyl group, a C.sub.3-8 cycloalkyl group, a C.sub.5-7 cycloalkenyl group or an (optionally substituted phenyl)C.sub.1-6 alkyl group wherein the alkyl, cycloalkyl and cycloalkenyl groups are optionally substituted by one or more groups of formula OR.sub.A in which R.sub.A represents H or a C.sub.1-6 alkyl group provided that a group of formula OR.sub.A is not located on the carbon attached to nitrogen;. R.sub.2 represents hydrogen, a C.sub.1-6 alkyl group, a C.sub.3-8 cycloalkyl group, halo, hydroxy, an (optionally substituted phenyl)C.sub.1-6 alkyl group, optionally substituted phenyl or R.sub.4 ; and PA0 R.sub.3 represents a group of formula (a) ##STR2## in which the phenyl ring is additionally optionally substituted and A represents NH, O, NHSO.sub.2, SO.sub.2 NH, a C.sub.1-4 alkylene chain, NHCO, NHCO.sub.2, CONH, NHCONH, CO.sub.2 or S(O).sub.p in which p is 0, 1 or 2, or A is absent and R.sub.5 is attached directly to the phenyl ring; PA0 and R.sub.5 represents optionally substituted phenyl and, additionally, when A is absent R.sub.5 represents a) a phthalimido group optionally substituted by halo or b) a pyrazolylamino group in which the pyrazole ring is optionally substituted by one or more of the following: hydroxy or optionally substituted phenyl; PA0 R.sub.4 represents a heterocyclic group; are described which are useful in treating proliferative diseases and disorders of the immune system in mammals. Processes to prepare these compounds and pharmaceutical compositions containing these compound are also described.

Protein tyrosine kinases (PTKs) are enzymes which catalyse the phosphorylation of specific tyrosine residues in protein. The post-translational modification of these substrate proteins, often enzymes themselves, acts as a molecular switch regulating cell proliferation and activation. Abnormal PTK activity has been observed in many disease states including benign and malignant proliferative disorders as well as diseases resulting from inappropriate activation of the immune system (autoimmunity, allograft rejection and graft versus host disease). It is believed that compounds which selectively inhibit the responsible PTKs may be useful therapeutic agents.
Compounds of formula A ##STR3## in which R.sub.1 is aryl, R.sub.2 is hydrogen, lower alkyl or halo and R.sub.3 is aryl are disclosed as inhibitors of the protein tyrosine kinase pp60.sup.c-src in WO96/10028. Compounds of formula A in which R.sub.1 is unsubstituted or substituted cyclo-lower alkyl or cyclo-lower alkenyl and R.sub.2 and R.sub.3 are as previously defined are disclosed in co-pending application WO 97/28161. Compounds of formula A in which R.sub.1 is lower alkyl or substituted lower alkyl and R.sub.2 and R.sub.3 are as previously defined are disclosed in co-pending application WO 97/32879.
Compounds of formula B ##STR4## wherein X is --N or CR.sub.7, where R.sub.7 is hydrogen, halogen, loweralkyl, loweralkoxy or -S-loweralkyl; Y is --N or --CH; R.sub.1 and R.sub.2 are each independently hydrogen, hydroxy, alkoxy, or acyloxy or R.sub.1 and R.sub.2 are both hydroxy protected with an individual hydroxy protecting group or with a single dihydroxy-protecting group or R.sub.1 and R.sub.2 are absent and there is a double bond between the carbon atoms to which R.sub.1 and R.sub.2 are attached; R.sub.3 is hydrogen, hydroxy, loweralkyl or alkoxy; R.sub.4 is inter alia (a) hydrogen, (b) amino, (c) halogen, (d) hydroxy or R.sub.3 and R.sub.4 taken together are .dbd.O, or taken together with the carbon atom to which they are attached, form a spirocyclic ring; R.sub.5 is inter alia hydrogen, loweralkyl or amino; and R.sub.6 is inter alia loweralkyl, aryl, heteroaryl or heteroarylalkyl; are disclosed as being adenosine kinase inhibitors in WO 96/40686.

Substituted 4-amino-7H-pyrrolo [2,3,-d]-pyrimidines as PTK inhibitors


A double-chamber tea bag has a centerfold that is crimped by squeezing it between a toothed wheel and a plain wheel and a headfold in which the front chamber has a flap that folds over the part of the end of the front chamber between triangular folds at each corner.

The present invention relates to a tea bag and to a method and apparatus for making it. In particular, the invention concerns a tea bag of the type having two chambers containing comminuted tea that is made by forming a strip of filter paper into a flattened tube, cutting the tube to length, folding the tube intermediate its ends along a W-fold to form two chambers, and joining the ends of the chambers by a headfold. Tea bags of this type are well-known and have been marketed for about 40 years. For example, Thomas J. Lipton Co. sells such tea bags under the trademark "FLO-THRU.RTM.." For convenience, this type of tea bag will be referred to herein as a "double-chamber" tea bag.
Double-chamber tea bags are produced by special machines, of which there are several manufacturers. One of the main suppliers is a German firm, Teepak, GmbH, which sells a machine known as the "Constanta." The Constanta and similar machines produce double-chamber tea bags by depositing measured masses of comminuted tea in spaced apart locations along the length of a strip of filter paper at a first station. The filter paper strip is then advanced through mechanisms that form it into a flattened tube by folding in portions along each side and bringing the edges together face to face with a band along one edge of the strip extending beyond the other edge of the strip. The extending band is folded over the other edge to form a loop, and the loop is folded over, thereby forming a doubly folded joint between the edges of the strip in which one edge is singly folded over, the other edge is doubly folded and the extending band is captured in a loop of the first edge. The doubly-folded joint, which is called a "centerfold," is crimped by moving the tube between a pair of wheels having serrated surfaces in the form of transverse, projecting teeth. The wheel that engages the side of the centerfold opposite from the folded over edges has a width approximately equal to the width of the centerfold. The wheel that engages the folded edges is somewhat narrower than the centerfold. The teeth are designed to mesh, such that they tend to form corrugations in the centerfold. The narrow toothed wheel is spring-loaded toward the wide toothed wheel to apply pressure to the centerfold and cause the fibers of the several layers that constitute the centerfold to intertwine and form mechanical bonds between the adjacent layers.
One problem with presently known double-chamber tea bags is that the centerfold occasionally comes apart when the tea is being made, thereby releasing some of the tea from the bag. The failure of the centerfold, which does not happen very often but is aggravating to the consumer when it does, generally results from a sudden build-up in the pressure of air in the bag due to heating of the air when hot water is poured onto it, usually accompanied by a mechanical force resulting from impingement of a water stream on the bag.
Another problem with double-chamber tea bags involves release of tea from the front chamber of the bag at the headfold, again due to an air pressure increase and the force of a water stream. The headfold of previously known double-chamber tea bags is produced by positioning an end portion of the front chamber back to back against an end portion of the back chamber such that a band adjacent the end of the rear chamber extends beyond the end of the front chamber. Triangular segments at each corner of both chambers adjacent their ends are folded over along respective coincident diagonal fold lines such the triangular segments overlie portions of the front chamber externally. The extending band of the rear chamber is folded over along a transverse foldline to form a flap that overlies portions of the triangular segments externally. A portion of the end of the front chamber between the diagonal folded segments is not folded and is merely covered but not effectively closed by the folded over flap of the rear chamber. Tea can escape from the open portion along the end of the front chamber.


Roller pairs and draw apparatus for processing glass ribbons are disclosed. The roller pairs applying force to a glass ribbon moving through the draw apparatus. The roller pairs include a first roller assembly and a second roller assembly positioned along opposite sides of the glass ribbon. A shaft of the second roller assembly is coupled to an actuation system that includes a repositionable support member allowing translation of the shaft of the second roller assembly in a direction transverse to the draw direction of the glass ribbon, a pneumatic actuator controlling a position of the contact wheel of the second roller assembly in the direction transverse to the draw direction of the glass ribbon, and a pneumatic reservoir in fluid communication with the pneumatic actuator delivering fluid at an elevated pressure to the pneumatic actuator.

Fusion draw processes are used in glass manufacturing operations to produce thin glass sheets that are used in a variety of products including flat panel displays. Glass sheets produced according to these processes typically exhibit enhanced flatness and smoothness compared to glass produced by different methods, such as the float method.
In order to produce glass ribbon in a draw process, pulling forces are applied to the glass ribbon in the direction of the draw via contact rollers while the glass is in a visco-elastic state. The glass ribbon is drawn by rollers which apply the pulling forces to stretch the glass ribbon in a draw direction (i.e., in a direction of glass travel) and in a cross-draw direction normal to the draw direction. The pulling forces process the glass to the desired thickness for use in commercial goods.
The physical interface of the rollers with the glass ribbon affects the stability of the glass ribbon during the draw process and affects the attributes of finished glass articles produced from the glass ribbon. In particular, the normal (pinch) force and normal force variation applied across the thickness of the glass ribbon by opposing rollers may affect glass attributes. Friction in the system used to manage the pinch force between opposing rollers reduces the effective normal force applied to the glass ribbon, and may lead to periodic and/or random variation in the force applied to the glass ribbon. Reduction in pinch force variation may reduce glass ribbon tension and reduce glass ribbon non-uniformity.
Accordingly, roller pairs and draw apparatuses incorporating roller pairs having alternative pinch force management systems are desired.

Roller pairs for processing glass ribbons and draw apparatuses incorporating the same


A device is provided for use to retain a condom or similar construction on the penis of a wearer, during intercourse. The device includes a trough member and an arrangement for maintaining the trough member in operative association on the user's penis, during performance of intercourse. A combination including a condom and such a device is also provided, as well as a method of use.

A condom is used on the human male for a variety of reasons. The typical reasons are to prevent transmission of disease and/or to prevent pregnancy. In use, the condom can sometimes slip off the human male. This is especially prevalent if the human male's penis becomes flaccid or only partially engorged. If the condom slips off the penis, its effectiveness can be compromised.

Condom retention device with a retaining strap