A control system and method generate torque comments for motion of a target system in response to observations of a source system. Constraints and balance control may be provided for more accurate representation of the motion as replicated by the target system.

In recent years, there has been a growing interest in using captured human motion data as examples to simplify the process of programming or learning complex robot motions. See, e.g., A. Nakazawa, S. Nakaoka, K. Ikeuchi, and K. Yoko, "Imitating human dance motions through motion structure analysis", Intl. Conference on Intelligent Robots and Systems (IROS), pages 2539-2544, Lausanne, Switzerland (2002). Captured human motion has been used to develop algorithms for 'learning from demonstration', a form of learning whereby a robot learns a task by watching the task being performed by a human. See, e.g., S. Schaal, "Learning from demonstration", In M. C. Mozer, M. Jordan, and T. Petsche, editors, Advances in Neural Information Processing Systems, chapter 9, pages 1040-1046. MIT Press (1997). One goal of 'learning from demonstration' has been to replace the time-consuming manual programming of a robot by an automatic programming process, solely driven by showing the robot the task by an expert teacher. Captured human motion has also been used in computer animation to 'retarget' motion of one articulated figure to another figure with a similar structure. See, e.g., S. Tak, O. Song, and H. Ko, "Motion balance filtering", Comput. Graph. Forum, (Eurograhics 2000), 19(3):437-446, (2000). See also, e.g., S. Tak and H. Ko, "A physically-based motion retargeting filter", ACM Trans. on Graphics, 24(1):98-117 (2005).
The majority of existing approaches to control a robot from human demonstration use three steps. First, human motion is recorded using a marker based optical system, a magnetic system, or a wearable mechanical device resembling an exoskeleton. The recorded motion is then used as an input to a constrained non-linear optimization procedure to generate a re-designed joint level robot motion. See, e.g., A. Ude, C. G. Atkeson, and M. Riley, "Programming full-body movements for humanoid robots by observation", Robotics and Autonomous Systems, 47:93-108 (2004). Constraints are also imposed to enforce the robot's kinematic, dynamic, and balance constraints. See, e.g., Y. Tamiya M. Inaba S. Kagami, F. Kanehiro and H. Inoue, "Autobalancer: An online dynamic balance compensation scheme for humanoid robots", In Int. Workshop Alg. Found. Robot, (WAFR), Lausanne, Switzerland, (2000). Given sufficient computation time, a retargetted motion can be optimized off-line to satisfy a prescribed performance measure subject to the constraints. The retargetted joint motion is then used as the desired joint command input to the robot's independent joint controller. In the absence of external disturbances, the generated robot motion is kinematically and dynamically admissible by the robot and can be executed by the robot's control scheme during run-time.
Such a process has limitations. First, the complexity of sensing and instrumentation used to record human motion is time consuming and often limiting for use outside the laboratory. Moreover, the off-line re-targeting solution based on optimization methods is generally not suitable for online or reactive control of robots in dynamic scenes or in the presence of external disturbances. These limitations restrict the applicability of the approach to laboratory settings with static environments. An effective system should be interactive and therefore computationally fast, should work in static and dynamic environments, and should not rely on special instrumentation for the human demonstrator nor the environment.

Control of robots from human motion descriptors


An exercise device which uses two generally opposing grips on guides to guide a user through circular movements for exercise of the human body. The grips may be movably mounted to side supports or a central base. Resistance to the user's movement of the grips may be added.

1. Field of the Invention
This present invention relates to an exercise method and an exercise device. More specifically, to an exercise device and method using guided upper body circular motion.
2. Related Art
A variety of resistance exercise devices are known in the art. Upper body exercise devices generally involve a linear, or near linear stroke-type movement back and forth, or up and down to simulate weight lifting. The motion on these devices is substantially a back and forth or modified back and forth (up and down) linear motion. Circular motion running or stepping exercise device to simulate running or walking with connected pedals or treadles which move together are known.
Back and forth linear motion exercise devices often require the user to start and stop at the end of each stroke-type movement. Hand pedaling connected bicycle-type hand pedals on connected sprockets are known for physical rehabilitation. It would therefore be a desideratum to have a non-linear motion exercise for the upper body with reduced stops and starts.

Dual circling exercise method and device


A liquid compound dispensing apparatus for dispensing a controlled amount of liquid compound onto a workpiece is described. The apparatus comprises a cartridge system. The cartridge system may accept a liquid compound cartridge containing liquid compound. The apparatus also comprises a plate, having a threaded bore, positioned above the cartridge system that is movable in a first and second direction, at least one plunger attached to the plate at a first end and attached to a piston at a second end. The piston is dimensioned to move within the liquid compound cartridge to displace liquid compound when the plate is moved in the second direction. A driving mechanism moves the plate in the first and the second directions to dispense product and comprises a motor, a threaded rod disposed through the threaded bore of the plate that is driven by a driving belt attached to the motor.

Single-part or one-part compounds may cure, set, or harden via a chemical reaction with an external energy source, such as radiation, heat, moisture or the like. Multi-part compounds may cure, set, or harden by mixing one or more component parts which chemically react. This reaction causes polymers to cross-link into acrylics, urethanes, and epoxies.
Polyepoxides, commonly known as epoxy resins or epoxies, are a class of reactive pre-polymers and polymers. As described above, epoxy resins may react with themselves, (e.g., one-part compound), or may react with various co-reactants, commonly referred to as hardeners or curatives, such as phenols, alcohols, and thiols, (e.g., two-part compounds). Reactions of epoxy resins, both with themselves or with a co-reactant, form a thermosetting polymer. Thermosetting polymers are generally characterized as strong, hard materials that are resistant to chemicals and temperature changes. Thermosetting polymers have a wide range of industrial applications, including adhesives, insulators, sealants, coatings, potting/encapsulation, automotive primer, use in electronic and electrical components, or the like.
Single-part or one-part compounds may be dispensed directly from their packaging, (e.g., a tube, a cartridge, or the like), whereas two-part compounds must be pre-mixed. Pre-mixing component parts ensures uniformity in the mixed components prior to a dispensing process. The pre-mixing process may be conducted manually or by an automated device.
A manual pre-mixing process generally requires a user to manually mix both component parts, for example with a mixing spatula and tray. This process is time consuming, results in a high rate of compound consumption, and is attributable to a high incidence of user rotation due to the physical labor required to mix the component parts. In addition, if the user employs a dispensing device, the user generally must load the compound into the dispensing device, which may result in a loss of some compound during a transfer.
Alternatively, an automated device may mix the two component parts and release the resulting compound into a separate compartment, such as a dispensing device, a dispensing syringe, or the like. Two-part compounds, generally characterized by limited working times, (e.g., 20 minutes or less), may begin to cure in the dispensing device and/or related components. This attribute may lead to clogging or inoperability of the dispensing device. This may result in increased maintenance, increased part replacement events, increased cleaning costs, and a high rate of liquid compound waste. One-part compounds may have similar limited working times and deficiencies. This problem may be common to high pressure dispensing valve systems with multiple component parts, such as a spool valve. Such systems are generally self-contained and are difficult to disassemble or are incapable of being disassembled. In such a system, a spool valve may become engulfed by cured compound and prevented from operating properly (e.g., the precision of liquid compound dispensed may vary substantially). Thus, there is a need for a dispensing system and related components that are designed to accommodate the limited working time of one-part and multi-part compounds.
Dispensing systems known in the art employ manual or pneumatically operated dispensing devices. Both manual and pneumatic dispensing devices use a time/pressure system. FIG. 1 is a diagram of a conventional time/pressure dispensing system 100. The time/pressure dispensing system 100 may be pneumatically operated. Referring to FIG. 1, there is shown a pneumatically operated dispensing syringe 105 comprising a plunger 115, and a tip 120. The dispensing syringe is attached to tube 110. Tube 110 may be attached to an air compressor and a vacuum. The compressor applies compressed air at a specific pressure to the plunger 115 to force a volume of a liquid compound 125 within the syringe 105 to be dispensed from the tip 120 onto a surface of a workpiece 130. In this time/pressure system, the higher the pressure and the longer it is applied, the greater the quantity of liquid compound will be dispensed. The vacuum may be used to prevent the liquid compound from dripping. Alternatively, no vacuum may be employed, and the liquid compound held within the syringe may be pulled back from the tip of the syringe due to a depressurization or decrease in the amount of applied pressure.
One of the deficiencies in such a time/pressure system is the inconsistent dispensing quantity caused by internal and external variations. For example, when pressure or force is applied to the liquid compound or a cartridge piston to dispense a quantity of liquid compound, there is a reactionary exertion of force on the piston in the opposite direction. This reaction force may increase when viscosity properties of the liquid compound increase. For example, pulsed pressure may heat the material, which may change the viscosity of the liquid compound and in turn may alter the volume of liquid compound that is dispensed. In addition, the reaction force may decrease as the amount of liquid compound in the dispensing device decreases. The dispensing pressure is generally maintained at a constant level and does not take into account the change in the reaction force, resulting in a high degree of variation in the quantity of liquid compound that is dispensed.
Moreover, additional dispensing parameters may vary as the syringe empties, resulting in variations in the amount of liquid compound dispensed. Vacuum-pull back systems may also be ineffective from preventing liquid compound from dripping and may pull the liquid compound away from the tip resulting in a variation in the volume of the next dispensed amount of liquid compound. Thus, there is a need for a dispensing device and related components that are designed to dispense precise amounts of liquid compound with a high degree of repeatability while taking into account the internal and external variations impacting such as system.


One embodiment of a computer system has processors, having address spaces the processors can address directly. Each address space is directly linked to at least one other address space by memory within more than its own address space. The total size of the address spaces within the system linked together either directly or through directly linked address spaces is greater than the address space any resource within the system can address directly.

A processor or other resource in a computer system may be capable of addressing memory and other resources directly using an address of a definite size. The maximum length of address that a resource can handle determines the extent of the address space that resource can address. A resource can access locations outside its own address space, but this typically requires indirect addressing procedures that require both time and resources. In a multi-processor system, several cells may be arranged to share a "coherency domain" of common, directly addressable address space. However, because each cell must generally be able to address the entire coherency domain directly, the total size of the coherency domain, and thus the sum of the sizes of the cells, is then limited to the address space of any one processor.

Communication in partitioned computer systems

Hewlett-Packard Development Company, L.P.


A processing apparatus that enables margin correction of X-ray intensity data includes a calculation unit configured to calculate an expansion rate of X-ray intensity data detected in a unit region on a marginal side on a basis of an intensity distribution resulted from detection of uniform X-ray and a first function generation unit configured to generate an allocation function that allocates the X-ray intensity data detected in the unit region on the marginal side to an outside unit region, on the basis of the expansion rate. Enabling margin correction on the basis of the intensity distribution resulting from detection of uniform X-ray makes it possible to correct the distortion of intensity distribution on the marginal side. As a result, it is possible to expand the detection region of X-ray intensity data.

The present invention relates to a processing apparatus, a method, and a program that enable margin correction of X-ray intensity data.
In recent years, hybrid pixel array detectors have been developed, which have pixels tiled vertically and horizontally on the backside of the sensor layer of semiconductors, with read-out chips being provided on the backside of the pixels. A detector with a pixel size of about 100 μm, for example, has a high positional resolution and is effective for measurement of diffracted X-rays.
For such a hybrid pixel array detector, forming a pattern of a guard ring on the margin is common as a measure against noise or leak current (see Patent Document 1). The structure results in that the sensitive region of the X-ray detection surface spreads outward along the electric field, and the region with tiled pixels becomes smaller than the sensitive region. In addition, the electric field of the margin within the sensor layer is distorted, and therefore the equipotential surface of the margin is a curved surface (see non-Patent Document 1). As a result, pixels on the margin cover a large area of the detection surface, and signals originated from outside the pixel positions on the detection surface enter the pixels.
On the other hand, against the existing phenomenon that a count value tends to be different from count values at other positions due to gaps between the read-out chips, there has been proposed an algorithm that sets virtual pixels and allocates count values among the virtual pixels, providing randomness thereto.
As described above, a hybrid pixel array detector requires intensity correction of the margin since signals originated from outside the pixel positions on the detection surface enter the pixels. In addition, aligning detectors for the purpose of achieving a larger area causes the margin of the detectors to be an undetectable region, whereby a gap is created.

Processing apparatus, method, and program


This disclosure relates generally to computer resource management over multiple cloud platforms, and more particularly to a system and method for provisioning of application environment and deployment of application across hybrid cloud platform. In one embodiment, a method is provided for provisioning an application environment across a hybrid cloud platform. The method comprises generating a platform independent provisioning template based on at least one of a resource specification and a configuration data. The platform independent provisioning template is compatible with multiple cloud platforms. The method further comprises generating a plurality of target platform artifacts compatible with a corresponding plurality of target cloud platforms based on at least one of the resource specification and the configuration data, associating the plurality of target platform artifacts with the platform independent provisioning template, and provisioning the application environment across the hybrid cloud platform by executing the platform independent provisioning template on each of the plurality of target cloud platforms.

In the current business environment, the use of cloud computing and cloud services has become ubiquitous for many organizations. Cloud computing employs a network of remote servers hosted on the communication network (e.g., Internet) to store, manage, and process data and to deliver hosted services. These services are broadly divided into three categories: Infrastructure-as-a-Service (IaaS), Platform-as-a-Service (PaaS), and Software-as-a-Service (SaaS). Cloud computing and storage solutions provide users and enterprises with various capabilities to store and process their data in third-party data centers.
It is often desirable to deploy a project with computing resources sourced from various cloud providers and/or data centers as the products and services offered by each cloud provider have their strengths and limitations. However, each cloud provider has a different approach and requires a different set of skills for provisioning (e.g., defining, making ready for use, setting-up, and so forth), using, and managing respective computing resources. For example, most cloud providers support a template driven provisioning capability which use application program interfaces (APIs) defined by the respective cloud provider to trigger the provisioning. However, while APIs are provided for doing the provisioning activity, they are different for each provider. Further, the format of the templates is different across providers. The default template provided by each of the cloud providers are quite diverse in nature and do not follow any suitable standards or convention. One has to create specific template for each of the providers, thereby requiring expertise on that specific environment. This gets further complicated with multiple heterogeneous cloud providers. On one hand the possibility of human error can be quite high on the other hand reusability of template may become a challenge. Similar to the case of the provisioning, deployment and validation across provider is cumbersome with the existing mechanism since the deployment and the validation are specific to a cloud provider and the scripts for one provider will not be compatible for execution on another provider's platform.
The existing mechanism therefore fails to provide (a) integrated provisioning of application environment and deployment of application across hybrid platforms in terms of automation, registration, execution and verification; and (b) reusable and interoperable artefacts (e.g., templates, scripts, and so forth) and processes provisioning of application environment and deployment of application across hybrid platforms. Accordingly, it is difficult and time consuming to provision, use, and manage computing resources across multiple cloud providers and/or data centers.

System and method for provisioning and deployment of application environment on hybrid cloud platform


A pressure bulkhead for the pressure-tight axial closure of a pressurized fuselage of an aircraft or spacecraft that can be put under an internal pressure, comprises a pressure dome, which is designed with a concave inner surface and a convex outer surface; inspection hatches, which each form an aperture in the pressure dome from the inner surface to the outer surface; and pressure covers for pressure-tight closure of the inspection hatches, wherein the pressure covers each have a cover and a pressure seal, wherein the cover is designed for the repeatedly releasable fixing of the pressure cover on the concave inner surface over the inspection hatch and wherein the pressure seal is formed at the edge of the cover for the pressure-tight closure of the cover with the pressure dome.

In order to keep an internal pressure of a passenger cabin at a suitable level, e.g. atmospheric pressure, even at high altitudes, passenger aircraft have a pressure bulkhead at a rear axial end, the bulkhead establishing pressure tightness of the passenger cabin relative to the primary structure of the aircraft fuselage. In modern aircraft construction, efforts are made to save weight as far as possible and, at the same time, to achieve adequate stiffness and robustness in respect of the many and various loads which occur. For this purpose, pressure bulkheads can be manufactured from metallic materials and/or fibre-reinforced composite materials, such as carbon fibre reinforced plastic (CFRP). In this case, the actual pressure bulkhead often has a basic shape resembling a spherical dome projecting in the direction of the rear of the aircraft, and is therefore also referred to as a pressure dome, which can, in turn, be provided with elongate and/or net-like reinforcing elements in areas that are particularly subject to loads, cf. EP 2 098 448 A1, EP 2 485 941 B1 and DE 10 2013 224 233 A1, for example. In general, a pressure bulkhead of this kind can comprise further structural elements, which are required for the pressure-tight closure of the relevant aircraft fuselage region and for transmitting the forces resulting from the internal pressure into the fuselage shell structure of the aircraft. For example, the pressure dome of the pressure bulkhead can be attached to one or more circumferential frames and/or an external skin of the fuselage by way of intermediate pieces and further components.
Sometimes, such pressure bulkheads have isolated through openings for supply lines, such as pipes, hydraulic and/or pneumatic lines or the like (cf. DE 10 2013 224 233 A1, for example). In order furthermore to ensure the pressure tightness of the pressure bulkhead, these openings are permanently closed in a pressure-tight way after assembly, e.g. with an attachment applied in a fixed manner. In typical designs, pressure domes have such a small curvature and hence projection in the direction of the rear that those regions of the fuselage which are situated at the rear behind the projection of the pressure dome can be inspected at any time without the permanently installed structure of the pressure bulkhead representing an obstacle. However, the small curvature has the effect that the outer edges of the pressure dome are aligned at a relatively steep angle to the surrounding fuselage, making actual attachment to the frames and/or the external skin complicated.
Given this background, it is the underlying object of the present disclosure to find improved solutions for the pressure-tight axial closure of a passenger cabin.


Valve module for influencing a fluid supply of a fluid-operated load, comprising a valve housing with a valve chamber being connected to an inlet port and an outlet port and a pilot chamber being connected to an operating port, comprising a valve member which is movably adjustable between a blocking position and a release position and further comprising an actuator which is motion-coupled to the valve member, wherein a position of the actuator and the valve member can be set as a function of a pressure applied to the pilot chamber, and further comprising a sensor device for detecting a position of the valve member and/or the actuator along a movement axis, and the sensor device comprises an electric coil arrangement which forms a ring around at least one fluid port from the group comprising the operating port, the inlet port and the outlet port.

The invention relates to a valve module for influencing a fluid supply of a fluid-operated load, comprising a valve housing which defines a valve chamber with a fluidically communicating connection to an inlet port and an outlet port and a pilot chamber with a fluidically communicating connection to an operating port, and further comprising a valve member which is movably accommodated in the valve chamber and which is adjustable between a blocking position and a release position in order to influence a free flow cross-section between the inlet port and the outlet port, and further comprising an actuator which is movably accommodated in the pilot chamber and motion-coupled to the valve member, so that a position of the actuator and the valve member coupled thereto can be set as a function of a pressure applied to the pilot chamber, and further comprising a sensor device for detecting a position of the valve member and/or the actuator along a movement axis.
From WO 2007/118674 A2, a valve device is known wherein a position of an armature or a valve piston is detected by means of a stroke sensor. The stroke sensor may be a non-contacting inductive sensor which is placed outside an armature chamber.


A flat strap holding apparatus includes a chassis and a first and second rotating hub that rotate in the interior of the chassis. The interior of the chassis being bounded by two opposing side walls of the chassis and a plurality of cross bars adjoined to the side walls. The chassis has a first and second end, each end containing the first and second rotating hub. A gripping surface of each rotating hub is proximate to a first and second gripping area in the interior of the chassis residing on the plurality of chassis cross bars. The first and second grip areas are arranged approximately orthogonal to one another. The first and second rotating hubs are arranged to rotate towards and away from the first and second gripping areas.

This application relates to apparatuses used with flat strap (webbing), specifically apparatuses and methods of using apparatuses to secure flat strap or to secure objects using flat strap.
Devices common to industries that utilize flat straps for securing loads usually encompass two broad areas of devices; sewn-strap camlock devices and lever ratcheting devices. Sewn-strap camlock devices utilize a strap permanently attached to the device by means of a loop sewn in one end of the strap affixed through an opening in the device housing with the opposing free end locked within the device by means of an eccentrically shaped hub rotated to trap the free end of the strap between the hub and the device housing. Lever ratcheting devices also incorporate a permanently attached section of strap to the device and a second non-permanently attached strap drawn into and captured on a hub within the device by means of a ratcheting lever mechanism. Sewn-strap camlock devices are commonly used in loop configurations where the strap surrounds objects being secured, binding them together and possibly to a stationary anchor if also encompassed by the strap as the free end of the strap is drawn into and held within the device. Ratchet devices more typically are used in point-to-point configurations where objects are confined between a stationary surface and a highly tensioned strap (ratchet lever induced) spanning the distance between two anchored points securely attached to the underlying surface. Ratchet mechanisms tend to be much larger in size than the simpler camlock devices but typically can induce far more load securing tension in the strap. In both types of devices a section of strap is in one way or another permanently attached to the device and will render both types of devices unusable if that section of strap breaks or is damaged in some manner.
Additionally, with one end or one strap permanently attached to the device, the device is limited to utilizing the attached strap. As such, would limit the device in the case of a sewn strap camlock to a single length of strap and in both types of devices to a particular strap material, thickness and hence strength and durability. In most cases the load bearing limits are determined by the intrinsic load bearing capacity of the strap material utilized with the device.
Because of design and structural differences between the two styles of device, a user is either limited to the simpler, smaller, easier to use sewn-strap camlock device or to the larger, unwieldly, more complicated higher tensioning capacity ratchet device.
And in both cases, with the strap permanently attached to the device, the sewn-strap camlock and the lever ratcheting devices are themselves positionally limited in any configured load bearing arrangement. For sewn-strap camlocks the tensioning device is confined to one end of the strap. For lever ratcheting devices the length of the permanently attached section of strap determines the physical position of the ratchet device. Tensioning of the configured strap arrangement is then induced by drawing strap into the fixed location device.

Systems and methods for an inline dual cam tensioning device


A trailer driver for guiding and driving a trailer when the trailer is disconnected from the hitch of a vehicle. The device includes a support frame and a ground engaging wheel rotatably mounted to the support frame. A mounting bracket is pivotally coupled to the support frame and is adapted for mounting the support frame to a trailer tongue. A motor is provided for rotating the ground engaging wheel. A steering handle upwardly extends from the support frame.

1. Field of the Invention
The present invention relates to devices for guiding and driving trailers and more particularly pertains to a new trailer driver for guiding and driving a trailer when the trailer is disconnected from the hitch of a vehicle.
2. Description of the Prior Art
The use of devices for guiding and driving trailers is known in the prior art. More specifically, devices for guiding and driving trailers heretofore devised and utilized are known to consist basically of familiar, expected and obvious structural configurations, notwithstanding the myriad of designs encompassed by the crowded prior art which have been developed for the fulfillment of countless objectives and requirements.
Known prior art devices include U.S. Pat. No. 3,861,482; U.S. Pat. No. 4,860,841; U.S. Pat. No. 4,210,217; U.S. Pat. No. 5,282,515; U.S. Pat. No. 4,162,711; and U.S. Pat. No. 3,861,483.
While these devices fulfill their respective, particular objectives and requirements, the aforementioned patents do not disclose a new trailer driver. The inventive device includes a support frame and a ground engaging wheel rotatably mounted to the support frame. A mounting bracket is pivotally coupled to the support frame and is adapted for mounting the support frame to a trailer tongue. A motor is provided for rotating the ground engaging wheel. A steering handle upwardly extends from the support frame.
In these respects, the trailer driver according to the present invention substantially departs from the conventional concepts and designs of the prior art, and in so doing provides an apparatus primarily developed for the purpose of guiding and driving a trailer when the trailer is disconnected from the hitch of a vehicle.


A coaxial cable connector including a connector body having a forward end, a rearward end, and a hollow cavity adjacent the forward end, the hollow cavity having an inward facing lip, a first insulator configured to fit within the hollow cavity in such a way that the inward facing lip resists removal of the first insulator from the hollow cavity, the first insulator having a central hole, a center conductor contact having a socket end and a pin end, the socket end located within the connector body toward the rearward end, the pin end passing through the central hole of the first insulator, a spring contact configured to fit into the socket end of the center conductor contact, and a second insulator having a central passageway, the second insulator having a first end and a second end, the first end adjacent the socket end of the center conductor contact.

Coaxial cable connectors are used to convey radio frequency (RF) signals in various applications. Coaxial cable connectors typically include a connector body, a coaxial cable attachment end, and an interface end. The coaxial cable connector is typically configured for attachment to a coaxial cable and connection to a standard interface, such as an F-type port or an IEC receptacle. Coaxial cables exist in which the center conductor is easily damaged during installation onto a coaxial cable connector. It is often difficult to determine whether a coaxial cable is fully inserted into the coaxial cable connector.
Thus, a need exists for a coaxial cable connector apparatus and method for protecting the center conductor during installation and providing a visible indication that the coaxial cable is fully inserted into the coaxial cable connector.

Coaxial cable connector for securing cable by axial compression


Provided herein are methods of treating cancer in a subject, by administering COH29 ((N-(4-(3,4-dihydroxyphenyl)-5-phenylthiazol-2-yl)-3,4-dihydroxybenzamide)). The methods of treating include treating a BRCA1-defective subject, a PARP1 inhibitor-resistant subject or a DNA-damaging anti-cancer agent resistant subject. The methods include treating cancer by administering COH29 and a DNA-damaging anti-cancer agent in a combined synergistic amount.

The antimetabolite drug hydroxyurea (HU) has been used to treat a variety of human cancers including chronic myelogenous leukemia, head and neck cancer, and others (1). Its primary anticancer target is ribonucleotide reductase (RR), which reduces ribonucleotides to their corresponding deoxy forms to supply dNTPs for DNA replication and repair (3,4). The human RR is composed of the hRRM1 and hRRM2 subunits (3,4). Following a genotoxic stimulus, an alternate RR enzyme is induced to supply dNTPs for DNA repair, which is composed of hRRM1 and p53R2 (a homologue of hRRM2 transactivated by the tumor suppressor protein p53) (5). Within cells, HU is known to inhibit both types of RR(4) through generating free radicals via oxidative transformation (6) that quenches free-radical mediated catalysis (3). However, pharmacologically, HU therapy suffers from short half-life in vivo and problematic side effects, most notably myelosuppression, and gastrointestinal and dermatologic effects (7).
Poly(ADP-ribose) polymerase-1 (PARP1) and PARP2 are both ADP-ribosyl transferases (ART) with roles in tumor development. ART members with PARP activity such as PARP1 contain a conserved catalytic domain with a highly conserved active site sequence (12-14). Following single strand DNA breaks PARP1 synthesizes ADP-ribose polymers from β-NAD+ substrate and transfers these to glutamate, lysine or aspartate residues of acceptor proteins (itself or other proteins), which are subsequently degraded by poly(ADP-ribose) glycohydrolase (PARG). During single strand DNA break repair (SSBR) or base-excision repair (BER), PARP1 and PARP2 interact with X-ray repair complementing protein-1 (XRCC 1) to recruit SSBR/BER factors, DNA polymerase β or DNA ligase III to the site of DNA damage (12-14). Without PARP1, the continuing presence of single strand breaks during DNA replication will lead to stalled replication forks, whose resolution require BRCA1 or BRCA2-mediated homologous repair (HR) (15,16). BRCA1 along with BRCA2 are tumor suppressor genes linked to the onset of familial breast cancers (11). In the absence of BRCA1, double strand breaks consequently accumulate, resulting in cell death via apoptosis. BRCA1/2-defective tumors may be sensitive to PARP1 inhibitors but can suffer from acquired resistance to PARP1 inhibitors. Thus, there is a need in the art for BRCA1/2-defective tumor treatments that avoid side effects and/or acquired resistance associated with current therapies. Accordingly, provided herein are solutions to these and other problems in the art.

Treatment of BRCA1-defective cancer or resistant cancers


In order to simplify the use of a portable emergency call device to place calls on a public telephone network, the emergency call receiver for receiving an automated call code signal from the portable device is part of a cordless telephone installation at the premises of a telephone subscriber. That installation includes a memory of telephone numbers subscribers to be alerted to the presence of an emergency call, together with logic for sequencing calls to several subscribers in repeated sequence until one of them receives the emergency call.

The magazine Funkschau, issue 12 of 1990, pages 56-59, discloses an emergency call system of the above-mentioned kind which includes a combination of an emergency call receiver and a telephone number transmitting apparatus controlled by the receiver. That combination needs to be designed and manufactured only for this particular purpose.


A kickstart system and method for operating gas discharge lamps is disclosed wherein the amplitude and frequency of the starting voltage are raised for a predetermined period of time to ionize the gas within the lamp and thereafter reduced to steady state operating levels.

Gas discharge lamps, such as fluorescent lamps, require a higher than normal operating voltage to be applied as a starting voltage to ionize the gas within the lamp. Traditionally, iron core and coil ballast systems operating at a frequency of 50-60 Hz have been employed to generate the higher than normal operating voltage. Iron core and coil ballast systems, however, are characterized by a low power factor, heavy weight, and large physical size. Additionally, they generate harmonics, radiate an audible buzz, and produce a bothersome light flicker.

Electronic ballast power supply for gas discharge lamp including booster start circuit responsive to power up condition


A flexible unit-cell actuator includes a shape memory alloy sheet having a fold between adjacent legs in one state and a heat source that upon activation concentrates heating of the shape memory alloy sheet at the fold relative to the legs to change the fold between one state and another state. The heat source may include resistive heating due to an electric current passing through the shape memory alloy sheet. The fold typically includes a reduced cross-sectional area and may include slits to increase electrical resistance at the fold relative to the adjacent legs. An actuator array includes a plurality of flexible unit-cell actuators formed in a sheet, each unit-cell actuator mechanically coupled to at least one other unit-cell actuator at a coupling region. Plural unit-cell actuators may be mechanically coupled in series, in parallel, or both, may be electrically connected in series, and may move along a defined curve or surface. A linear or curvilinear actuator includes a guide, a plurality of bearings or support elements slidable along the guide, and an array of actuators coupled between adjacent bearings and circumferentially about the bearings. An actuator includes a plurality of segments fanning from a hinge and shape memory alloy actuators coupled between adjacent segments to cause the segments to fan in an out about the hinge.

Conventional actuators, such as electromagnetic motors and piezoelectric actuators, are components of many devices including medical instruments, robotic probes, consumer electronics and surveillance systems. Electromagnetic motors and piezoelectric actuators can be expensive and bulky, and can require complicated control electronics.
Shape memory alloy actuators are known, but can involve significant amounts of heat generation and can have high power requirements.
Alternatives to conventional actuators are needed in applications where space and weight are limited, such as laparoscopic medical probes, small robotic probes, and micro-lens positioning systems.
Laparoscopic procedures present a fast growing market in medical robotics. Laparoscopic probes require very small, yet powerful actuators to operate inside a patient's body. Conventional electric motors present limitations in size, weight, and transmission mechanisms.
Lenses placed in cameras, including auto focus and zoom lenses in digital cameras, often use piezoelectric motors, which are expensive to fabricate.
Furthermore, using conventional actuators for orienting small cameras, such as those used in surveillance systems, in small robots, or in consumer electronics, is difficult because conventional actuators typically require transmission mechanisms which add weight and size.

Flexible actuator based on shape memory alloy sheet


Methods and circuits for power supply arrangement and control are disclosed herein. In one embodiment, a switching regulator controller can include: (i) a first feedback circuit for sensing an output of a switching regulator to compare against a regulation reference, and to generate a control signal suitable for matching the output of the switching regulator to the regulation reference during a steady state operation of the switching regulator; and (ii) a second feedback circuit for sensing a regulation difference between the output and the regulation reference, and to generate an adjustment signal in response to the regulation difference, where the adjustment signal adjusts the control signal under transient conditions to improve transient responses of said switching regulator.

Voltage regulators, such as DC-to-DC voltage converters, are used to provide stable voltage sources for various electronic systems. Efficient DC-to-DC converters are particularly needed for battery management in low power devices (e.g., laptop notebooks, cellular phones, etc.). A switching voltage regulator generates an output voltage by converting an input DC voltage into a high frequency voltage, and then filtering the high frequency input voltage to generate the output DC voltage. Specifically, the switching regulator includes a switch for alternately coupling and decoupling an input DC voltage source (e.g., a battery) to a load (e.g., an integrated circuit (IC)). An output filter, typically including an inductor and a capacitor, may be coupled between the input voltage source and the load to filter the switch output, and thus provide the output DC voltage. A controller (e.g., a pulse width modulator (PWM), a pulse frequency modulator, etc.) can be used to control the switch to maintain a substantially constant output DC voltage.
Traditional switching regulators use a transconductance amplifier or operational amplifier as an error amplifier for amplifying a difference between an output feedback level and a reference level. To stabilize the regulation loop, a transfer function of such an error amplifier should be designed to accommodate the poles and zeroes in a regular power stage transfer function. However, the power stage transfer function in a switching regulator often varies with the operation conditions (e.g., input voltage, output current, etc.). Thus, the transfer function of the error amplifier might be conservatively designed in switching regulators to achieve good stability margin under all operation conditions, resulting in relatively poor transient responses.

Mixed mode control for switching regulator with fast transient responses

Silergy Semiconductor Technology (Hangzhou) Ltd


A collision avoidance apparatus capable of executing an appropriate vehicle control in order to avoid a collision between an own vehicle and a movable object is provided. A collision avoidance apparatus for avoiding a collision between an own vehicle and a movable object includes: a laterally-existing movable object detector for detecting for a movable object that approaches from a direction lateral to the own vehicle; a side collision determination section for determining whether or not a risk that the own vehicle and the movable object collide with each other is high, when the laterally-existing movable object detector has detected the movable object that approaches from the direction lateral to the own vehicle; a passage and avoidance determination section for determining, when the risk that the own vehicle and the movable object collide with each other is determined to be high, whether or not a possibility that a collision between the own vehicle and the movable object can be avoided by the own vehicle passing in front of the movable object, is high; and an accelerated state/decelerated state controller for controlling the own vehicle to be in one of an accelerated state and a decelerated state, according to a determination result of the passage and avoidance determination section.

Apparatuses and systems for predicting collision between vehicles, and controlling the vehicles so as to avoid the collision have been developed to date.
An example of the collision avoidance apparatus as described above is disclosed in Patent Literature 1. A vehicle travelling support apparatus disclosed in Patent Literature 1 firstly obtains information on travelling of another vehicle, such as a position of the other vehicle approaching an own vehicle, by communication between the vehicles. Subsequently, the vehicle travelling support apparatus determines whether or not the own vehicle collides with the other vehicle, based on a travelling state of the own vehicle, and the information on the travelling of the other vehicle. When the collision between the own vehicle and the other vehicle is predicted, the vehicle travelling support apparatus controls the travelling state of the own vehicle so as to alleviate impact of the collision. Specifically, the vehicle travelling support apparatus executes a vehicle control by, for example, decreasing a speed of the own vehicle according to a steered state of the other vehicle.


Lubrication device for a ball joint bearing block.

The invention relates to a device designed for lubrication of a bearing block with a ball joint.
More precisely, the invention relates to a device to automatically lubricate a ball joint in a closed circuit, during rotation movements of a hinge pin supported by the bearing block.
The invention is particularly but not exclusively applicable to bearing blocks supporting landing gear on the structure of an aircraft. In this case, lubrication is done during landing gear extension and retraction movements.
An aircraft retractable landing gear comprises several parts, such as the main fitting of the landing gear and the strut, that are equipped with a number of hinge pins fixed in rotation to the aircraft structure, in order to define the same number of rotation axes (for example two axes of rotation in the transverse direction relative to the aircraft). These axes of rotation define a down and up movement for the landing gear, in the case of the aircraft landing gear.
The connection between the different hinge pins in the landing gear and the aircraft structure is frequently defined by the use of bearing blocks fitted with ball joints. These ball joints enable the different hinge pins in the landing gear to add pivoting movements with respect to the aircraft structure, in addition to rotation movements allowed by the different axes of rotation. These pivoting means, also called xe2x80x9cswiveling phenomenonxe2x80x9d, cause slight rotations of the landing gear about two other axes of rotation that define an orthogonal system with the axis of rotation considered.
The swiveling phenomenon occurs for example when deformations of the aircraft structure take place. These deformations take place particularly during maneuvers on the ground (taxiing) or during some flight phases during which high stresses may be applied to the said structure.
The ball joints in these ball joint bearing blocks usually comprise a ball capable of pivoting into a cage. One procedure for manufacturing such a ball joint is described in document U.S. Pat. No. 1,693,748; The cage in this ball joint is made from a single piece, one end of which is machined to the required shape before the ball is inserted into the said cage. An annular protuberance is formed on the outside of the cage, at its second end. This second end of the cage is then deformed by inserting the said cage by force fitting it into its support. This has the effect of creating the final shape of the cage and enclosing the ball inside it.
This process becomes difficult to implement when the dimensions of the ball joint are large. In this case, the cage may be composed of two secondary half cages inserted in a cylindrical primary cage to enable assembly of the ball.
The above mentioned deformations of the aircraft structure may cause relative movements between the ball and the cage, corresponding to the swiveling phenomenon already mentioned, and translation displacements, or even slight rotations, at the hinge pin at the inside of the ball, if the said hinge pin is not fixed inside the ball.
These displacements under load have the effect of applying friction forces on the bearing block ball joints. These friction forces are particularly high if the loads producing the deformations are high and if the friction coefficient between the surfaces is bad. From this point of view, it is known that the coefficient of friction varies particularly as a function of the materials present and the lubrication.
Friction forces can create a resisting torque between the ball and the cage that can prevent the ball joints from fulfilling their function entirely to compensate for deformations. Friction forces may also make it impossible for the hinge pin to rotate within the ball under satisfactory conditions, when a torque and/or axial forces are applied to the said hinge pin.
These phenomena can sometimes cause damage to landing gear hinge pins, for example due to occurrence of local overstresses at the ends of the bearing block, due to bending of the hinge pin that causes a longitudinal misalignment of the hinge pin in the bearing block.
These phenomena may also cause rotation of the secondary half cages in the primary cage. This rotation causes misalignment of the lubrication orifices and lubrication grooves. The result is that grease can no longer be replaced in the said grooves, which can have the consequence of causing damage to insufficiently lubricated surfaces, in other words damage to the ball joint.
Finally, the phenomena caused by friction forces may also cause damage to the fittings forming the structural parts of the landing gear, when torques and parasite forces have been applied to them.
These various problems are particularly sensitive when deformations of the aircraft structure are large. Frequently, these deformations themselves increase with the flexibility of the aircraft, which is usually higher for large aircraft. In this case, the above mentioned problems related to friction forces need special attention.
One known technique of reducing friction forces consists of lubricating firstly the contact surfaces between the ball and the bearing block cage in which this ball fits, and secondly contact surfaces between the hinge pin of the landing gear and the reaming made in the ball into which this hinge pin fits; This lubrication is done by injecting grease between the said contact surfaces during maintenance operations.
More precisely, surfaces to be lubricated are usually provided with grooves or slots in which grease can circulate and can therefore be distributed over these surfaces. Grease is injected under pressure using a pump, through grease nipples connected to the grooves. Old grease is expelled from the grooves through appropriate orifices.
Maintenance operations are usually carried out approximately every 500 hours of operation of the landing gear, corresponding to intervals of about 4 months for a medium haul aircraft, under normal operating conditions.
This technique for the renewal of grease used to lubricate ball joint bearing blocks in aircraft landing gear introduces several problems.
Thus, we have seen that the grease is only renewed periodically after a number of operations of the landing gear between two maintenance operations. Therefore, the grease ages, which is usually accompanied by a deterioration to its lubrication properties. This degradation is worsened by pollution, temperature and pressure variations, etc.
Furthermore, if the quantity of new grease injected during a maintenance operation is insufficient, it is possible that not all old grease will be expelled from the lubricated surfaces. In this case, lubrication of the said surfaces will not be as good because the old grease will remain mixed with new grease. This situation is particularly likely, since old grease can sometime block up the grooves, preventing it from being entirely replaced by new grease.
Furthermore, after a number of operations of the landing gear, some of the grease is expelled on the edges of the lubricated surfaces. Therefore, lubrication of these surfaces is not as good due to the lack of grease.
Specifically, the purpose of the invention is a device for lubrication of a ball joint bearing block, with an innovative design such that it renews grease between the contact surfaces at every rotation of the hinge pin, in a closed circuit, particularly to limit aging of the grease, the risk of no grease being present and the risk of the grooves being blocked by old grease, in order to improve the lubrication quality and reduce grease consumption.
According to the invention, this result is achieved by means of a device for lubrication of a ball joint bearing block comprising a pivot hinge pin, the device comprising at least one lubrication groove for the ball joint bearing block, characterized in that the device also comprises a lubricant reservoir connected through a closed circuit to the groove, pumping means designed to circulate the lubricant in the circuit between the reservoir and the groove, and means of activating the pumping means under the effect of a rotation movement of the pivot hinge pin.
This device renews the lubricant, in other words usually grease, between the lubricated surfaces of the bearing block during each rotation of the pivot hinge pin. Therefore, depending on the capacity of the reservoir, grease is therefore used much less frequently than if a lubrication device according to prior art is used. This limits aging and consequently improves the lubrication quality.
Furthermore, since grease frequently circulates in the grooves, the obstruction of grooves by old grease is much less probable than when a device according to prior art is used.
Furthermore, since the pumping means inject grease into the grooves during each rotation of the pivot hinge pin, there is no longer any risk of poor lubrication of contact surfaces due to lack of grease, as is possible with a device according to prior art.
Furthermore, the device according to the invention is capable of renewing grease in a closed circuit. Therefore, grease consumption is limited to the renewal of grease during periodic maintenance operations.
In one preferred embodiment of the invention, the device comprises at least two lubrication grooves and means of cyclically distributing the lubricant to each of the said grooves, during successive rotation movements of the pivot hinge pin.
Advantageously, the pumping units comprise a piston free to move in a given direction inside the lubricant reservoir, in order to divide the reservoir into a number of variable volume chambers.
In this case, a first of the said chambers is advantageously connected to a first end of a first groove through a first safety valve, the second chamber is connected to the second end of the first groove through a second safety valve provided with non-return means, the second chamber is connected to a first end of a second groove through a third safety valve and the first chamber is connected to the second end of the second groove through a fourth safety valve fitted with non-return means.
In general, the ball joint bearing block comprises a ball joint cage, a ball joint ball mounted in the ball joint cage and the said pivot hinge pin which passes through a reaming formed in the ball joint ball. The first groove is then formed between the ball joint cage and the ball joint ball and the second groove is formed between the ball joint ball and the pivot hinge pin.
Preferably, first leak tightness means are provided between the ball joint cage and the ball joint ball, on each side of the first groove, and second leak tightness means are provided between the ball joint ball and the pivot hinge pin, on each side of the second groove.
To enable replacement of grease during maintenance operations, a passage for injection of new grease advantageously joins a first grease nipple to the first end of the first groove and a passage for expulsion of old lubricant connects the first chamber to a second grease nipple.
In one advantageous variant embodiment, the two chambers with variable volume are connected to a compensation chamber that contains lubricant kept under pressure by appropriate means, such as a second piston. This variant can reduce the dimensions or use seals with lower sealing characteristics.
In the preferred embodiment of the invention, the lubricant reservoir and the mobile piston are preferably housed inside the pivot hinge pin, so that its center line is coincident with the center line of the pivot hinge pin.
In the latter case, the means of actuating the pumping means advantageously include a connecting rod, the first end of which is hinged on the piston at a location eccentric from the said common center line, and a second end of which is hinged on a structure fixed to the bearing block cage at a location that is also offset from the said common center line.
According to one preferred non-limitative application of the invention, the pivot hinge pin forms part of an aircraft landing gear.
Successive operations to retract and extend the landing gear then cause successive rotations of the pivot hinge pin in one direction or the other, with the effect of injecting lubricant alternately into the first groove and the second groove.

Ball joint bearing block lubrication device

Abstract: The device comprises at least one reservoir grease (30), a pump (34) capable of circulating grease between the reservoir and at least one bearing block lubrication groove (28), and a system (36) designed to actuate the pump (34) at every rotation movement of a hinge pin (16) of the bearing block. Preferably, there is a first groove (28) between the cage (24) and the ball (22) of the ball joint, and a second groove between the ball (22) and the hinge pin (16). Each rotation of the hinge pin (16) thus alternately controls injection of grease into one of the two grooves. One preferred application is lubrication of the hinge pins of aircraft landing gear.


A ureteroscope system includes a handle; an elongated shaft extends from the handle to a distal end and includes a working channel which is opened at the distal end; an external member extends from a proximal end to a distal end and is coupled to the shaft, the member includes a hub and a tube defining a first external channel; and a coupling mechanism defines first and second tubes and is coupled the distal end of the member to the distal end of the shaft. The first tube defines a first lumen and the second tube defines a second lumen which is sized and shaped to receive a distal end of the member. A proximal portion of the first tube is sized and shaped to be inserted into a distal portion of the shaft such that the first lumen is opened to the working channel.

A single channel flexible ureteroscope often has a working channel with a small diameter—around 3.6 French (F) or about 0.47 inches. This small diameter limits the size or quantity of devices that can fit through the working channel, as well as the size of objects, such as stone debris, that can be extracted while a device remains within the working channel—i.e., a laser fiber used to fragment kidney stones with laser energy. Often, the laser fiber must be removed from the channel before suction is applied through the working channel to extract the stone fragments. The laser fiber must then be reintroduced into the working channel to continue fragmenting kidney stones.
Dual channel flexible ureteroscopes are available but are often not as efficient as a single channel flexible ureteroscopes. For example, dual-channel flexible ureteroscopes are typically less maneuverable and provide less visibility because additional space in the ureteroscope shaft is dedicated to the second channel. Furthermore, dual channel ureteroscopes are costly to obtain and maintain.


The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions. One aspect of the invention provides compounds of formula (1):

1. Field of the Invention
The present invention relates generally to inhibitors of histone deacetylase. The present invention relates more specifically to N-(2-amino- and hydroxyphenyl)amide compounds and pharmaceutical compositions thereof, and their use in the inhibition of histone deacetylase.
2. Technical Background
In eukaryotic cells, nuclear DNA associates with histones to form a compact complex called chromatin. The histones constitute a family of basic proteins which are generally highly conserved across eukaryotic species. The core histones, termed H2A, H2B, H3, and H4, associate to form a protein core. DNA winds around this protein core, with the basic amino acids of the histones interacting with the negatively charged phosphate groups of the DNA. Approximately 146 base pairs of DNA wrap around a histone core to make up a nucleosome particle, the repeating structural motif of chromatin.
Csordas, Biochem. J., 265: 23-38 (1990) teaches that histones are subject to post-translational acetylation of the ε-amino groups of N-terminal lysine residues, a reaction that is catalyzed by histone acetyl transferase (HAT1). Acetylation neutralizes the positive charge of the lysine side chain, and is thought to impact chromatin structure. Indeed, Taunton et al., Science, 272:408-411 (1996), teaches that access of transcription factors to chromatin templates is enhanced by histone hyperacetylation. Taunton et al. further teach that an enrichment in underacetylated histone H4 has been found in transcriptionally silent regions of the genome.
Histone acetylation is a reversible modification, with deacetylation being catalyzed by a family of enzymes termed histone deacetylases (HDACs). The molecular cloning of gene sequences encoding proteins with HDAC activity has established the existence of a set of discrete HDAC enzyme isoforms. Grozinger et al., Proc. Natl. Acad. Sci. USA, 96:4868-4873 (1999), teaches that HDACs may be divided into two classes, the first represented by yeast Rpd3-like proteins, and the second represented by yeast Hd1-like proteins. Grozinger et al. also teaches that the human HDAC-1, HDAC-2, and HDAC-3 proteins are members of the first class of HDACs, and discloses new proteins, named HDAC-4, HDAC-5, and HDAC-6, which are members of the second class of HDACs. Kao et al., Gene & Development 14:55-66 (2000), discloses an additional member of this second class, called HDAC-7. More recently, Hu, E. et al. J. Bio. Chem. 275:15254-13264 (2000) discloses the newest member of the first class of histone deacetylases, HDAC-8. Zhou et al., Proc. Natl. Acad. Sci. U.S.A., 98:10572-10577 (2001) teaches the cloning and characterization of a new histone deacetylase, HDAC-9. Kao et al., J. Biol. Chem., 277:187-93 (2002) teaches the isolation and characterization of mammalian HDAC-10, a novel histone deacetylase. Gao et al, J. Biol. Chem. 277(28): 25748-55 (2002) teaches the cloning and functional characterization of HDAC-11, a novel member of the human histone deacetylase family. Shore, Proc. Natl. Acad. Sci. U.S.A., 97:14030-2 (2000) discloses another class of deacetylase activity, the Sir2 protein family. It has been unclear what roles these individual HDAC enzymes play.
Studies utilizing known HDAC inhibitors have established a link between acetylation and gene expression. Taunton et al., Science, 272:408-411 (1996), discloses a human HDAC that is related to a yeast transcriptional regulator. Cress et al., J. Cell. Phys., 184:1-16 (2000), discloses that, in the context of human cancer, the role of HDAC is as a corepressor of transcription. Ng et al., TIBS, 25 (March):121-26 (2000), discloses HDAC as a pervasive feature of transcriptional repressor systems. Magnaghi-Jaulin et al., Prog. Cell Cycle Res., 4:41-47 (2000), discloses HDAC as a transcriptional co-regulator important for cell cycle progression.
Richon et al., Proc. Natl. Acad. Sci. USA, 95:3003-3007 (1998), discloses that HDAC activity is inhibited by trichostatin A (TSA), a natural product isolated from Streptomyces hygroscopicus, which has been shown to inhibit histone deacetylase activity and arrest cell cycle progression in cells in the G1 and G2 phases (Yoshida et al., J. Biol. Chem., 265:17174-17179 (1990); Yoshida et al., Exp. Cell Res., 177:122-131 (1988), and by a synthetic compound, suberoylanilide hydroxamic acid (SAHA). Yoshida and Beppu, Exper. Cell Res., 177:122-131 (1988), teaches that TSA causes arrest of rat fibroblasts at the G1 and G2 phases of the cell cycle, implicating HDAC in cell cycle regulation. Indeed, Finnin et al., Nature, 401:188-193 (1999), teaches that TSA and SAHA inhibit cell growth, induce terminal differentiation, and prevent the formation of tumors in mice. Suzuki et al., U.S. Pat. No. 6,174,905, EP 0847992, and JP 258863/96, disclose benzamide derivatives that induce cell differentiation and inhibit HDAC. WO 03/087057, WO 03/092686, WO 03/024448, WO 2004/069823, WO 00/71703, WO 01/38322, WO 01/70675, WO 2004/035525, WO 2005/030705, and WO 2005/092899, among others, disclose additional compounds that serve as HDAC inhibitors. Other inhibitors of histone deacetylase activity, including trapoxin, depudecin, FR901228 (Fujisawa Pharmaceuticals), and butyrate, have been found to similarly inhibit cell cycle progression in cells (Taunton et al., Science 272:408-411, (1996); Kijima et al., J. Biol. Chem., 268(30):22429-22435 (1993); Kwon et al., Proc. Natl. Acad. Sci. USA 95(7):3356-61 (1998)).
These findings suggest that inhibition of HDAC activity represents a novel approach for intervening in cell cycle regulation and that HDAC inhibitors have great therapeutic potential in the treatment of cell proliferative diseases or conditions. There is therefore a need to identify additional HDAC inhibitors and to identify the structural features required for potent HDAC inhibitory activity.

This patent is subject to a terminal disclaimer.

Abstract: in which T, A and X are as described herein.


Methods and systems are provided for managing a GUI of a web browser. When a user interaction with a tab presentation control is detected, a horizontal tab strip having first navigation tab controls for a set of webpages is removed, and a vertical tab strip having second navigation tab controls for the same set of webpages is displayed in a vertical column in the browser. In response to detecting a user hover interaction with the vertical tab strip while the vertical tab strip is in a collapsed state, the vertical tab strip is expanded from the collapsed state to an expanded state. In response to termination of the user hover interaction, the vertical tab strip is collapsed from the expanded state to the collapsed state. The vertical tab strip in the collapsed state occupies a smaller portion of the GUI then the vertical tab strip in the expanded state.

Today's widescreen laptops and high-end desktop monitors may be ideal for viewing video, but often, they pose challenging constraints for user interface developers and users. For example, the wider aspect ratios may limit valuable vertical space that is needed for displaying webpage content in a browser graphical user interface (GUI). Additionally, browser GUIs often include various information and/or controls across the top or bottom of the screen (e.g., a title bar, web address window, tool bar, webpage navigation tabs, etc.) that further reduce screen real estate in the vertical dimension and compete for space with the webpage content. At the same time, webpage content is often displayed in a somewhat narrow area in the center (e.g., horizontal center) of the browser GUI, leaving blank areas on either side of the webpage content.

Navigation tab control organization and management for web browsers


A disposable glove and system are provided that has features and characteristic that enable a cuff opening of the glove to more easily open, thereby assisting in donning the glove. The disposable glove system includes stacked glove configurations for mounting and storage. The disposable glove system also includes features that make the disposable gloves easier to dispense from a dispenser with minimal user contact with the outer surface of the disposable gloves.

The service industry, such as food service or cleaning service, often requires workers to wear gloves to prevent cross-contamination. Gloves are often one-time use disposable gloves where the risk of cross-contamination is reduced with frequent glove changes. For example, a food service worker will don fresh gloves for each customer to prevent cross-contamination of foods or after handling money or other non-food items.
Conventional elastomeric (nitrile or similar) gloves are generally manufactured using a dipping process over a form of a hand. These gloves are designed to be close in size to a user's hand and stretch when donned to conform tightly to the hand. Although the conformed fit is beneficial to the usability, elastomeric gloves are generally costly and overcoming the elastomeric nature of the material makes for a difficult and time consuming donning process.
A conventional and cost-effective solution is to use two layers of substantially non-elastic plastic material (polyethylene or similar) sealed together to form the anterior (palm side of the hand) and posterior (back side of the hand) portions of the glove. The gloves have the general profiled shape of a hand but because the flat profiled shape of these gloves needs to fit the three-dimensional shape of a user's hand, the gloves require excess material for the geometric transformation. Two-layer gloves are also resistant to transitioning to the three-dimensional donned shape, preferring to hold to their flattened shape. Flattened two-layer gloves are prone to bending and kinking, making them further resistant to donning and the internal surfaces of plastic gloves generally stick to wet surfaces such that sweaty or wet hands even further complicate the donning process. Two-layer gloves are difficult and slow to don, they do not provide for a good fit, and they are generally uncomfortable to wear.
Some quick don glove solutions exist, which feature stacks of gloves with relatively easy access to the glove opening for inserting a hand and separating a glove from the stack with the action of donning. Quick don glove products can be advantageous over other glove products available but existing options suffer from a number of shortcomings. Existing solutions either consist of overly involved equipment or overly simplistic approaches that impede the path of donning with remnant glove stack material or glove mounts that reside directly in the path of donning.
The difficult donning process for both elastomeric gloves and non-elastic gloves is also further complicated since the user should not contact the exterior surfaces of the glove to limit the spread of contamination.
Escalating public awareness and understanding of the environmental impact of disposable plastic products provides another deterrent for the usage of disposable gloves in general. Conventional two layer gloves are often contaminated with food and unable to be properly recycled where food products inhibit the recyclability of plastic, consequently, gloves are usually thrown out and not recycled.


A dynamic port that extends from the bottom wall of an oil reservoir that surrounds the lower guide bearing of a reactor coolant pump and is in fluid communication within an oil level gauge. The dynamic port is rotatable into and out of the oil flow path to adjust the dynamic oil level shown by the oil level gauge when the pump is at operating speed to be substantially equal to the static oil level when the motor is at rest.

1. Field of the Invention
The present invention relates to apparatus for measuring the level in an oil reservoir of a motor and more particularly to such apparatus for measuring the dynamic oil level in a reservoir surrounding a bearing on a motor shaft. More particularly, the invention relates to apparatus for monitoring the level of lubricating oil in the oil pot of a motor, the invention having particular application to reactor coolant pump motors in nuclear power plants.
2. Description of Related Art
The reactor coolant pump motors drive the reactor coolant pumps which are part of the primary reactor coolant system in a nuclear power plant. The motors are typically arranged with vertical shafts. The bearing and lubrication system of a vertical motor is usually contained in two separate oil pots (also referred to as oil reservoirs). An upper oil pot contains the upper guide or radial bearings and the total thrust bearing system. The lower oil pot contains the lower guide or radial bearings. Each of these oil pots is typically provided with cooling coils for carrying cooling water to dissipate the heat which is generated by the bearing systems.
The design of the oil pots is such that the oil level within the pot should be monitored during operation to ensure that the oil level is not rising above or falling below the expected levels. A rising level might indicate, for example, a water leak within the cooling coils which results in water entering the pot and mixing with the oil. If such a situation were to persist, the lubricating ability of the oil would be sharply diminished and, more importantly, the oil/water mixture would overflow the pot and migrate toward the hot reactor coolant pump, where a fire could result.
A falling oil level would be indicative of a leak in the oil pot system which allows oil to escape from the pots. If this situation persists, the level of oil in the pot would drop below the level where the oil lubricates the bearings and thus result in severe damage to the bearings and possibly to the motor shaft/runner. More importantly, this condition could also result in a fire if the oil, with a flash point of 420 degrees fahrenheit (215.56 degrees centigrade) reaches the pump surfaces which may be as hot as 550 degrees fahrenheit (287.87 degrees centigrade).
Because of these real and serious concerns, each of the two oil pots is equipped with an oil level detector which provides an alarm signal to a control room in the event of an unusual oil level condition. Some concern exists that the detector may generate a high level alarm when, in fact, the system is operating normally, i.e., there is no leakage of water into the oil pump. A major contributor to this potential problem, particularly with respect to the lower oil pot, is the expansion of the oil due to heat entering the oil pot from the reactor cooling pump. A temperature rise of 50 degrees fahrenheit (10 degrees centigrade) in the oil of the oil pot, for example, would result in a volume expansion of approximately 0.6 gallon (2.27 liters) in a 30 gallon (113.56 liters) capacity pot. This is reflected in the rise of the oil level within the pot and the detector of 0.5 inch (1.27 centimeters) or more, and could result in a spurious high level alarm signal.
Recently, a number of nuclear plant operators of pressurized water reactors have experienced a high oil level alarm on the lower bearing oil reservoir shortly after reaching normal operating temperature and pressure. The oil level during the start-up period had gradually increased during heat-up from an initial level of +0.8 inches (+2.0 centimeters) immediately following the across-the-line start. One plant operator noted that upon initial start-up of the pump motor, the oil level abruptly increased from the static zero level to this initial dynamic level. In the attempt to clear the ensuing alarm, two actions were performed. First, the lower oil level alarm switch assembly was adjusted approximately 3/16 of an inch (0.48 centimeters) upward, to the maximum limit of adjustment. This raised the alarm actuation for both the high oil level alarm point as well as the low oil level alarm point for the lower bearing oil reservoir. Prior to this adjustment, the lower oil reservoir alarms were set to occur at approximately +1.25 inches (+3.2 centimeters) above static for the upper alarm and approximately −1.25 inches (−3.2 centimeters) below static for the lower alarm. Second, the vent line between the oil level sight glass and the oil alarm reservoir was disconnected right above the sight glass venting both the alarm reservoir and the sight glass to the containment atmosphere. These directions were taken to clear the oil level alarm encountered during the heat-up of the plant by raising the overall alarm window and provide a more representative oil level based on a known oil inventory in the lower oil pot.
As the plant heat-up continued, the lower oil reservoir again experienced a high level alarm at 1.3 inches (3.3 centimeters) above the static oil level. The plant went on to operate at power and continued to experience a high oil level alarm; with the oil level oscillating between +1.3 and +1.5 inches (+3.3 and +3.8 centimeters) and tracking with changes in ambient and component cooling water temperatures.
The main purpose of the oil level indicating system on the main coolant pumps in pressurized water reactor systems manufactured by Westinghouse Electric Company LLC is for monitoring the oil inventory within the bearing oil reservoir. The original design concept behind the system used on the lower guide bearing oil reservoir on Westinghouse reactor coolant pump motors was a simple transference of indicated oil level from inside the bearing oil reservoir to an alarm switch reservoir and sight glass which is external to the lower bearing oil reservoir (sometimes referred to herein as the oil pot). This approach was taken to eliminate errors due to turbulent flows within the bearing oil reservoir that would be generated if the alarm float switch and sight glass were placed directly into the bearing oil reservoir.
The technical principle for the design of the oil level indicating system of Westinghouse reactor coolant pump motors is a simple force balance accomplished by transference of the pressures from the bearing reservoir to the alarm reservoir generated by the static elevation of a column of fluid. When the fluid is at rest, the height and therefore pressure differences of the oil columns in each reservoir are equal, assuming homogeneous temperatures and fluid properties throughout the system. The alarm reservoir oil level therefore matches the bearing reservoir oil level and oil inventory is easily monitored. Once the fluid is set in motion, however, it's been observed that the pressures in the bearing reservoir can change due to variations in temperature and velocity of the oil. This may unbalance the forces acting on the two oil columns causing unequal heights, or levels, of the columns The oil may also become mixed with air, i.e., aeration; causing changes in oil properties that can tend to contribute to changes in the height of one or both oil columns. Thus, an oil level indicating system must consider these factors in addition to those of the operating environment when used for oil inventory monitoring.

Dynamic port for measuring reactor coolant pump bearing oil level


The present invention relates to a node in a wireless communication system, the node comprising at least a first, a second and a third antenna function. A first and second downlink signal, and a first and second uplink signal are transferred via said antenna functions, which together form a first total antenna function and a second total antenna function. The first and second downlink signals are transferred via the first total antenna function, and the first and second uplink signal are transferred via the second total antenna function. The second downlink signal and the second uplink signal are transferred via a common connection connected to a filter means which is arranged for separating these signals to connect them to different antenna functions. The present invention also relates to a corresponding method.

Many mobile communications systems, for example implemented using the radio access standard known as LTE (Long Term Evolution), make use of the concept referred to as MIMO (multiple input, multiple output), i.e., multiple parallel wireless communication signal streams originating from one (distributed) location and intended for another (distributed) location with all signal streams using the same time and frequency resource.
For example, for a desired performance, transmitting antennas for the individual signals are suitably arranged to inject signal power into the propagation environment in such a way as to create an effective propagation channel with high rank when the signals are detected by similarly suitably arranged antennas at the receiving end of a multi-stream wireless communication link.
In the following, the two ends of a communication link will be denoted "access point" and "terminal", these two representing for example a macro base station and laptop computer, respectively, exchanging information in a mobile communications system.
A propagation channel has a certain rank, where the rank corresponds to a measure of the number of independent routes a signal may propagate for a given number of antenna ports; in other words the rank is the number of degrees of freedom which is granted by a certain arrangement of antenna functions and the environment where the signal propagates i.e., the wave propagation channel. How antenna functions are arranged in the propagation environment affects the rank.
A high rank propagation channel, i.e., a channel with a rank close to the number of available independent signals, can be achieved by arranging antennas in such a way that variations in amplitude and phase of the individual transferred signals become decorrelated. Spatially separated antennas as well as orthogonally polarized antennas are two common means for achieving decorrelation. Which one of these two arrangements that is the preferred one depends on the specific propagation environment and the properties of the access point and the terminal.
In some MIMO implementations, for example LTE systems, a concept called pre-coding is available. Pre-coding involves a coherent transmission of the same signal from more than one antenna. This results in beam-forming or polarization forming, depending on the properties of the antennas used for transmitting the signal and also depending on the propagation environment. For co-polarized antennas covering essentially the same angular space in an idealized free-space environment, the transmitted signals will add coherently, resulting in beams or, more generally, an interferometer-like electromagnetic field behavior, with in- and out-of-phase signal addition for different directions in space, which depends on the antenna separation distance. Similarly, for antennas with different, for example orthogonal, polarizations, different polarization states will result for different directions in space.
Real propagation environments will cause a less distinct division between beam-forming and polarization forming. However, for many antenna installations, for example when the transmitting antennas are placed and oriented in an access point to radiate on downlink into an effective free-space environment, i.e., an environment without any significant obstacles present between the antenna and the so-called Fraunhofer region, farfield patterns can and will develop before the effects of scattering and multi-path propagation set in. This is of course works reciprocally on uplink.
In previously known solutions, the same antennas or antenna functions are used for transmission and reception. For a TDD (Time Division Duplex) system, the transmitted and received signals are separated in time, and for an FDD (Frequency Division Duplex) system, the transmitted and received signals are separated in frequency. Alternatively, independent radio chains are used for transmission or reception for those antennas that are used only for uplink or downlink. Some implementations of switched antenna systems used for wireless LAN provide an example of the latter whereas conventional base stations in all present standards are an example of the former.
The first existing solution, a system using the same antenna function for downlink and uplink, as manifested by the radiation pattern properties, cannot provide simultaneous optimized performance of both links, if the downlink and uplink system performance have different optima with respect to the radiation pattern. An example is that in certain scenarios beam-forming with closely spaced co-polarized antennas can be optimal for downlink while receiver diversity with dual-polarized antennas can be optimal for uplink.
The second existing solution, a system using independent radio chains or, at the very least, separate feeder lines, will require more feeder cables than the number of parallel signal streams. For example, a 2×2 MIMO system with two co-polarized antennas used for beam-forming on downlink, and two orthogonally polarized antennas used for diversity reception on uplink, will require three feeder cables.
There is thus a need for a node in a wireless communication system where the antenna functions can be made to differ for downlink and uplink in an efficient manner.

Node in a wireless communication system with different antenna diversity methods for uplink and downlink


A method and system of selectively projecting images is disclosed. An illuminated area is created on a projection surface by directing a light source to the projection surface. The illuminated area is detected with a camera. Electrical signals are transmitted from the camera to the projector, the electrical signals being indicative of the position of the illuminated area in relation to the projection surface. Based on the received electrical signals, an image and a second image are projected on the projection surface. The image is projected on the illuminated area of the projection surface. The second image is projected on an area of the projection surface that is not illuminated by the light source. Applications of this method and system include the projection of background and foreground images creating the illusion of an x-ray beam, the projection of a normal image and an overblown image creating the illusion of a magnifying light beam.

1. Field of the Disclosure
The present disclosure relates to projection systems. In particular, it relates to entertainment projection systems to provide an illusory reality to the observer.
2. General Background
Entertainment environments are always seeking to provide guests with extraordinary and unforgettable experiences that they could not otherwise live through in their day-to-day lives. A common fantasy that would be an extraordinary experience is to have "x-ray" vision—the ability to look through solid matter and seeing what is inside a certain object or behind a particular wall. In an entertainment environment, it is therefore desirable to provide the guest with the illusion of seeing through objects as if the guest had x-ray vision.
In educational environments, it is likewise desirable to show the insides of certain objects to realistically demonstrate the functioning of the object. Allowing the student to view through the outside casing of a machine, for example, would prove an ideal academic setting to teach the workings of such machine.

Interactive projection system and method


An overlay device for premises status message display on a video monitor is provided. The overlay device includes a processor in communication with a memory, the memory storing instructions, which when executed by the processor, cause the processor to: receive a premises status message from at least one premises device, receive a media signal for display on the video monitor, combine the media signal with the premises status message, and transmit the combined media signal and premises status message for display of the combination of the media signal and the premises status message by the video monitor.

The demand for systems that monitor homes and businesses for alarm and lifestyle conditions has continued to grow as more home and business owners seek to protect their premises from various hazards and threats such as intrusion, fire, carbon monoxide and flooding, or to control lifestyle systems such as lighting, thermostats and energy management devices.
When a sensor such as a motion detector is triggered, a representative at a remote monitoring center receives an alarm event code and initiates a response process, including contacting a homeowner or others on a contact list and/or first responders such as local firefighters and/or police to request a dispatch to the premises.
For example, a remote monitoring center may include a remote life safety monitoring center that monitors life safety features associated with a control unit at the premises in which the remote monitoring center receives life safety data from the control unit. For example, with respect to fire and carbon monoxide detectors/sensors, life safety data may include at least one carbon monoxide readings, smoke detection reading, sensor location and time of reading, among other related to these detectors that may be communicated to the remote monitoring center. In yet another example, with respect to a door contact detector, life safety data may include at least one of sensor location and time of detection, among other data related to the door contact detection that may be communicated to the remote monitoring center 20.
Alarm event data from the premises may be used by the remote monitoring center in running through various life safety response processes in notifying the owner of the premises, determining whether an actual alarm event is occurring at the premises, and notifying any appropriate response agency (e.g., police, fire, emergency response).
The same or separate remote monitoring center may also include a life style system/service that allows for various life style features associated with the control. The remote life style system may receive life style data from the control unit. For example, with respect to temperature control, life style data may include thermostat readings. In yet another example, with respect to video capture devices, life style data may include at least one of captured images, video, time of video capture and video location, among other data related to video capture devices that may be communicate to the remote monitoring center. The remote monitoring center may also provide updates to the control unit such as updates to features associated with life safety and/or life style operating system. Those of ordinary skill in the art will appreciate that video and other data may also be used by the life safety monitoring center
These systems do not readily allow a user to easily see alarm events or obtain other information from the alarm system, whether life safety or life style, because the user must be at or near a panel or have a wireless device such as a smartphone running an application with them. The result is that that there is a lack of real-time feedback of alarm or lifestyle events, as they occur, to a user at the premises.

Devices and methods to display alarm and home events on video monitors