The increasingly interconnected and complex business environment demands business executives to be equipped with highly developed cross-functional skills and the capacity to integrate responsible decision making in business. To develop students with these attributes, the business higher education sector is expected to employ teaching and learning techniques that produce graduates with the ability and capacity for managing businesses responsibly. However the traditional, linear thinking embedded in current business higher education material and delivery methods hinders such an approach. This article presents an innovative approach to teach responsible decision making through the design, development, and implementation of an online simulation. This teaching approach uses a total enterprise computer simulation which exposes students to interactive, multidisciplinary decision making across functional, societal, environmental, and economic issues. The article also discusses the implications of the findings for theory and practice of designing and using computer simulations for teaching and learning in business higher education.


Abstract In this narrated review, we draw attention to the use of happiness as a novel outcome measure in clinical research studies regarding patients with stroke. Commonly used outcome measures in clinical trials in stroke rehabilitation include the modified Rankin Score (mRS), Functional Impairment Measures (FIM), Barthel Index and quality of life (QoL). Despite being a part of QoL, happiness is arguably a significant construct on its own. While QoL assesses perceptions of various extrinsic aspects of life, happiness may be used as a measure of subjective enjoyment of life after an illness. We review the literature discussing the use of happiness as a formal outcome measure in stroke care and subacute and long-term stroke rehabilitation. Ultimately we recommend the wider use of happiness as an outcome measure where appropriate in these settings.


The human body is continuously at battle with bacterial pathogens from its surrounding environment. This leads to a strong selective pressure on both the pathogen and the host. Accordingly, humans and bacteria have evolved elaborate measures to fight one another. In humans the complement system forms the first line of defense against invading bacteria. These trigger the activation of the complement system. This leads to various effector functions one of which entails the formation of large lytic pores on the bacterial membrane, thereby directly killing Gram-negative bacteria. These pores are called the membrane attack complex MAC) and their formation is mediated by a group of proteins collectively referred to as the MACPF family which act in concert to drill a hole through the membrane of target cells. We have determined crystal structures of two components of the MAC, the complex between C5b and C6 and the MACPF domain of C8a?. These structures yielded the unexpected result that the MACPF domain resembles cholesterol dependent cytolysins (CDCs), a group of well studied bacterial pore-forming toxins. These structure show for the first time how formation of the MAC is initiated and allow us to construct a model for how the proteins of the MAC go from a water soluble state in the blood to a membrane inserted pore on the surface of bacterial targets. Like CDCs, MACPF domains contain two amphipathic segments folded against the protein. Upon activation these segments can unfold to form extended ?-hairpins that ultimately form the lining of a large ?-barrel pore. The structures have greatly expanded our understanding of how the proteins of the MAC function together to form a bactericidal pore but also form a starting point of biochemical studies that will increase our understanding even further. A second key component humans use to fight of infections is phagocytosis. In this process, white blood cells like neutrophils, recognize antibodies bound to e.g. bacteria through so called Fc? receptors. Staphylococcus aureas, a Gram-positive bacteria that is well known for its numerous immune evasion strategies, has evolved a protein, FLIPr and its homologue, FLIPr-like, that are able to bind to the Fc? receptor most important for phagocytosis by neutrophils, Fc?RIIa This binding inhibits phagocytosis thereby conferring a strong advantage for invading bacteria. We have solved the crystal structure of the complex between FLIPr-like and Fc?RIIa and characterized the binding of the proteins with isothermal calorimetry. The structure give a clear picture of how FLIPr-like inhibits antibody binding to the receptor as their binding sites almost fully overlap. Furthermore, the structure also gives insight into the specificity FLIPr-like has for the different isoforms of Fc? receptors. Collectively the data could aid in the design of novel receptor isoform specific inhibitors to aid in the treatment of auto-immune diseases and inflammatory disorders.


Current treatment of upper limb amputation restores some degree of functional ability, but this ability falls far below the standard set by the natural arm. Although acceptance rates can be high when patients are highly motivated and receive proper training and care, current prostheses often fail to meet the daily needs of amputees and frequently are abandoned. Recent advancements in science and technology have led to promising methods of accessing neural information for communication or control. Researchers have explored invasive and noninvasive methods of connecting with muscles, nerves, or the brain to provide increased functionality for patients experiencing disease or injury, including amputation. These techniques offer hope of more natural and intuitive prosthesis control, and therefore increased quality of life for amputees. In this review, we discuss the current state of the art of neural interfaces, particularly those that may find application within the prosthetics field. PM R 2011;3:55-67


Glucose, insulin, and growth hormone values were studied prospectively in 75 premature infants during the first five days after birth. Intravenous glucose was given at a mean rate of 4.7–4.9 mg./kg./in. (range 3–7). Mean birth weight was 1,394 α 47 gm. (mean α S.E.M.). Blood glucose values were significantly higher on days 1 and 2 than on days 3 to 5. Hypoglycemia (blood glucose <20 mg./100 ml.) occurred in two SGA and one AGA infants. On the other hand, hyperglycemia (>125 mg./100 ml.) was found in 32 of the 75 (42.7 per cent) infants. A significantly greater number of deaths occurred in infants with hyperglycemia (19/32) than in those with normoglycemia (19/32) than in those with normoglycemia (5/43). Mean plasma insulin values were significantly higher on days 1 and 2 (15 α 3 and 18 α 4 μU./ml.) than on days 3 and 4–5 (6 α 1 and 7 α 2 μU./ml.). In addition, mean insulin levels were significantly higher during hyperglycemic than during normoglycemic glucose levels at similar postnatal age. Growth hormone values were higher during the first three days than subsequently, but the values were similar in normoglycemic and hyperglycemic groups. Significant negative correlations were seen between glucose values on the first two days of postnatal life and birth weight, gestational age, and Apgar scores, whereas positive correlations were found with FiO2 and respiratory distress score (RDS).


This book focuses on the design and testing of large-scale, distributed signal processing systems, with a special emphasis on systems architecture, tooling and best practices. Architecture modeling, model checking, model-based evaluation and model-based design optimization occupy central roles. Target systems with resource constraints on processing, communication or energy supply require non-trivial methodologies to model their non-functional requirements, such as timeliness, robustness, lifetime and evolution capacity. Besides the theoretical foundations of the methodology, an engineering process and toolchain are described. Real-world cases illustrate the theory and practice tested by the authors in the course of the European project ARTEMIS DEMANES. The book can be used as a cookbook for designers and practitioners working with complex embedded systems like sensor networks for the structural integrity monitoring of steel bridges, and distributed micro-climate control systems for greenhouses and smart homes


This study examines the issues surrounding 'student voice' in a specific Chinese context, and assesses the key elements of leadership that could enhance student voice in that context. It reports the results of a research conducted in a community-based educational centre in Hong Kong that provides after-school educational and social adjustment programmes for children aged 6–15. Although the centre promotes the principle of student voice, the perceptions and attitudes of students and teachers towards this principle are found to be different. Analysis draws on several sources, including semi-structured interviews, observations and related documentation. Based on the data collected, the gaps between teachers' and students' perspectives of student voice are identified, and cultural perspectives are discussed. Student voice is found to be a key issue for children. The recommendations for institutional leaders who seek to promote this concept include valuing student voice, embracing a willingness to construct a new partnership with students and ensuring consistent whole-institution commitment.


The relative frequency response is an important acoustic feature used to characterise acoustic targets. This response has been defined as the sv, volume backscattering coefficient, for a specific frequency relative to that of a reference frequency (38 kHz). The acoustic data commonly used in these calculations are derived from integrated measurements in a region containing multiple targets. In this study the relative frequency responses at 18, 38, 70, 120, and 200 kHz have additionally been measured using filtered target strength data on all frequencies. The spatial comparability of the sv-data is thus avoided, while the single-target detection becomes a new challenge. Target strength was extracted from in situ measurements, using calibrated and digitised data from a Simrad EK60 with split-beam transducers transmitting simultaneously at all five frequencies. Selected series with nearly pure catches of Atlantic cod (Gadus Morhua L.), saithe (Pollachius virens L.) and Norway pout (Trisopterus esmarkii L.) were analysed. The frequency response derived by the new method is compared with standard integration method.


We have recently demonstrated that all-trans retinoic acid (RA), the active metabolite of vitamin A, is an efficient alternative to chemotherapy in the treatment of acute promyelocytic leukemia (AML3). We have further shown that, in these AML3 cells, the gene of the retinoic acid receptor-alpha (RAR alpha) is translocated from chromosome 17 to chromosome 15, and fused to a new gene, PLM. This results in the expression of both normal and chimeric RAR alpha transcripts in AML3 cells. The PLM-RAR alpha protein may account for the impairment of differentiation and thus leukemogenesis, but not for the paradoxical efficacy of RA in these cells. In an attempt to elucidate RA's differentiative effect in AML3 patients, the present work examined the in vitro and in vivo modulation of the normal RAR alpha transcripts by all-trans RA in seven cases of AML3. In all samples, Northern blot analysis revealed a low expression of the two normal RAR alpha transcripts compared with other human myeloid leukemic cells. No modulation was observed after 4-8 d of in vivo therapy with all-trans RA 45 mg/m2 per d. In vitro incubation with all-trans RA, however, increased the level of expression of the normal RAR alpha transcripts in AML3 cells but not in other AML leukemic subtypes. This modulation of the two normal RAR alpha transcripts appeared to be an early and primary event of RA's differentiating effect. We therefore suggest that up-regulation of the normal RAR alpha gene expression by pharmacological concentrations of all-trans RA may restore the normal differentiation pathway in these cells.


Gender plays a poignant role in almost any historical narrative, particularly in the record of piracy and government sponsored privateering. The opportunity for women to embrace various social classes at will in the late 18th century came out of an environment in which ideas about politics, economics, and race continually shifted. Society was in chaos, and social mores, therefore, changed constantly. Even as some pirates transported slaves for profit, others took on former slaves as captains, rejecting religions, nationalities, and former loyalties for the sake of freedom. Female pirates such as Ann Bonny and Mary Read exemplify a case of crossing sexual borders in search of social and economic liberation. They forfeited their femininity to steal, sail, and drink with men, like men. Yet in the end, they intentionally became pregnant – a decidedly female enterprise – to escape imprisonment and death. In the midst of nations' trans-Atlantic battles for God and money, pirates wrote their own rules. Women fought like men, slaves captained ships, and entire cities fell overnight. Identity, as well as gender, was a mercurial feature, and important so long as it served a purpose. This paper therefore considers not only the motivations that women had for turning to piracy, but also the social conditions that allowed for such radical opportunities.


Summary: Lipids from the autotrophic thermophilic archaeobacterium Desulfwolobus ambivalens grown under aerobic and anaerobic conditions were analysed and compared with those of Sulfolobus solfataricus, a related micro-organism. The ether lipids of aerobically and anaerobically grown D. ambivalens, as well as those of S. solfataricus, had the same general features except for the degree of cyclization of the C40 isopranic chains. The quinone content of D. ambivalens was strongly affected by growth conditions. Aerobically grown cells contained caldariellaquinone, 6-(3,7,11,15,19,23-hexamethyltetracosyl)-5-methylthiobenzo[b]thiophen-4,7-quinone (83% of the quinone pool), sulfolobusquinone, 6-(3,7,11,15,19,23-hexamethyltetracosyl)-5-methyl-benzo[b]thiophen-4,7-quinone (16%) and the tricyclic quinone benzo[1,2-b; 4,5-b']dithiophen-4,8-quinone (trace amounts). In anaerobically grown D. ambivalens sulfolobusquinone was the only quinone present.


BACKGROUND
Glutamatergic hypofunction is affected in schizophrenia. The decrement ofpresynaptic glutamatergic marker remarkably vesicular glutamate transporter type 1 (VGLUT1) indicates the deficit ofglutamatergic and cognitive function in schizophrenic brain. However there have been afew studies in VGLUT2. Brahmi, a traditional herbal medicine, might be a new frontier of cognitive deficit treatment and prevention in schizophrenia by changing cerebral VGLUT2 density.

OBJECTIVE
To study cognitive enhancement- and neuroprotective-effects of Brahmi on novel object recognition task and cerebral VGLUT2 immunodensity in sub-chronic phencyclidine (PCP) rat model of schizophrenia.

MATERIAL AND METHOD
Cognitive enhancement effect study; rats were assigned to three groups; Group-1: Control, Group-2: PCP administration and Group-3: PCP + Brahmi. Neuroprotective effect study; rats were assigned to three groups; Group-1: Control, Group-2: PCP administration and Group-3: Brahmi + PCP Discrimination ratio (DR) representing cognitive ability was obtained from novel object recognition task. VGLUT2 immunodensity was measured in prefrontal cortex, striatum, cornu ammonis fields 1 (CA1) and 2/3 (CA2/3) of hippocampus using immunohistochemistry.

RESULTS
DR was significantly reduced in PCP group compared with control. This occurred alongside VGLUT2 reduction in prefrontal cortex, but not in striatum, CA1 or CA2/3. Both PCP + Brahmi and Brahmi + PCP groups showed an increased DR score up to normal, which occurred alongside a significantly increased VGLUT2 immunodensity in the prefrontal cortex, compared with PCP group.

CONCLUSION
The decrement of VGLUT2 density in prefrontal cortex resulted in cognitive deficit in rats receiving PCP. Interestingly, receiving Brahmi after PCP administration can restore this cognitive deficit by increasing VGLUT2 density in prefrontal cortex. This investigation is defined as Brahmi's cognitive enhancement effect. Additionally, receiving Brahmi before PCP administration can also prevent cognitive impairment by elevating VGLUT2 density in prefrontal cortex. This observation indicates neuroprotective effect of Brahmi. Therefore, Brahmi could be a new frontier of restoration and prevention of cognitive deficit in schizophrenia.


This study investigates self-esteem and locus of control in a cross-cultural context, comparing British and Turkish students. Sex differences are also considered. The relationship between academic achievement and the personality variables of self-esteem and locus of control is also examined.  The sample consisted of year-11 secondary school students. 190 were British and 315 were Turkish. In order to collect data, the Coopersmith Self-Esteem Inventory (SEI), the Nowicki-Strickland Internal-External Control Scale and the Crandall et al. Intellectual Achievement Responsibility Scale (IAR) were used. The findings of this study indicated that English subjects had higher self-esteem scores than the Turkish subjects. The results also showed that cultural differences were bigger among males than among females. The results reveal no sex differences when both the English and the Turkish samples were combined. However, among English subjects, the males had significantly higher self-esteem scores than their female counterparts, while no sex differences existed between Turkish males and females. Cross-cultural comparisons of global locus of control between English and Turkish cultures showed that there was no significant difference between English and Turkish subjects. Furthermore, the results also indicated that English males were significantly more internal than English females, whereas Turkish males and females did not differ. The data also indicated that English and Turkish students did not differ in academic locus of control. When the English and the Turkish males and females were compared, the results showed that there were no significant differences between English and Turkish females but English males were more internal than the Turkish males. Furthermore, the results also indicated that Turkish females were more internal than Turkish males, whereas, English males and females did not significantly differ. When the relationships between self-esteem and academic achievement were investigated, the data indicated that most of the self-esteem scales related significantly with academic achievement for the English and the Turkish samples. However the majority of the correlation coefficients were classified as moderate or low for the English sample as well as for the Turkish.  The study also revealed that both the global and the academic locus of control scales were significantly correlated with the academic achievement (GPA) for both of the English and Turkish samples. Achievement also had a stronger relationship with global locus of control than the academic locus of control for both the English and the Turkish samples. In order to find out the best predictor of achievement, multiple regression analyses were carried out using the Stepwise procedure. Regression analyses, using academic  achievement (GPA) scores as the criterion variable, found the Academic Self-Esteem variable as the best independent variable to predict achievement for both English and Turkish groups. However, together with the other independent variables, they accounted for only 19 % of the variance in achievement for the English group and 13 % of the variance for the Turkish group.


This method does not make the assumption of infinite sets of conducting lands to introduce spatial periodicity. The perturbation method is computationally efficient and can be used for any design, including those that use very few repeated sets of conducting lands. The results obtained by this method are compared with previous results which include experimental data. The method is extended to rotary micromotors and to three-dimensional problems.<<ETX>>


STUDY QUESTION
What are the effects of maternal and fetal soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF) concentrations on fetal and childhood growth patterns?

SUMMARY ANSWER
An angiogenic profile that is characterized by both low early pregnancy maternal sFlt-1 and PlGF concentrations and higher sFlt-1 concentrations, lower PlGF concentrations or a higher sFlt-1:PlGF ratio in umbilical cord blood is associated with a reduced fetal and childhood growth.

WHAT IS KNOWN ALREADY
An imbalance in maternal and fetal sFlt-1 and PlGF concentrations has been suggested to affect pregnancy outcomes. However, their effects on longitudinal fetal and childhood growth remain largely unknown.

STUDY DESIGN, SIZE, DURATION
This study was performed in 5980 mothers and 4108 of their children, participating in the Generation R Study; a population-based prospective cohort study from fetal life onwards in Rotterdam, the Netherlands (2001-2005).

PARTICIPANTS/MATERIALS, SETTING, METHODS
Blood samples were obtained from mothers in early and mid-pregnancy and from the umbilical vein at delivery. Fetal and childhood growth characteristics (weight and length) were measured repeatedly by ultrasound and physical examinations until the age of 6 years. We assessed the associations of maternal and fetal angiogenic factors with fetal and childhood growth using repeated measurement regression models. Logistic regression models were used to determine associations between angiogenic factors and small for gestational age at birth (SGA).

MAIN RESULTS AND THE ROLE OF CHANCE
Compared with early pregnancy maternal sFlt-1 concentrations in the lowest quintile, early pregnancy maternal sFlt-1 concentrations in the highest quintile were associated with a higher fetal weight growth resulting in a higher birthweight (difference in birthweight 0.33 standard deviation score (SDS); 95% Confidence Interval (CI) 0.25-0.41), a lower risk of SGA (Odds Ratio (OR) 0.36; 95% CI 0.27-0.48) and a subsequent higher weight growth until the age of 6 years. Early pregnancy maternal PlGF concentrations in the lowest quintile were associated with a reduced weight growth pattern resulting in a smaller birthweight (difference in birthweight -0.34 SDS; 95% CI -0.44, -0.25), an increased risk of SGA (OR 3.48; 95% CI 2.39-5.08) and a lower weight growth throughout childhood. An early pregnancy maternal sFlt-1:PlGF ratio in the highest quintile was associated with a higher fetal weight growth pattern from 30 weeks onwards, resulting in a higher weight at birth (difference in birthweight 0.09 SDS; P-value <0.05), which remained present until the age of 2 years. Newborns with higher umbilical cord sFlt-1 concentrations, lower PlGF concentrations or a higher sFlt-1:PlGF ratio showed a lower fetal and childhood weight growth from 30 weeks gestation onwards until the age of 6 years (P-value <0.05). Similar patterns were observed in relation to fetal and childhood length growth.

LIMITATIONS, REASONS FOR CAUTION
The study is an observational study. Therefore, no causal relationships can be established.

WIDER IMPLICATIONS OF THE FINDINGS
Both a maternal and fetal angiogenic imbalance may affect fetal and childhood growth. Changes in angiogenic profiles may be involved in the pathways linking fetal growth restriction with the long-term risk of vascular disease in adulthood.

STUDY FUNDING/COMPETING INTERESTS
The first phase of the Generation R Study is made possible by financial support from The Erasmus Medical Centre, Rotterdam, the Erasmus University Rotterdam, and the Netherlands Organization for Health Research and Development (ZonMw 21000074). V.W.V.J. received additional grants from the Netherlands Organization for Health Research and Development (ZonMw VIDI). M.I.B.-B. is financially supported by the Bo Hjelt foundation (grant 2009). The authors have no competing interests.


This paper is focused on a comparison between Model-Free Control and Active Disturbance Rejection Control methods. These two techniques do not require a detailed mathematical description of the system, since they base on the on-line estimation and rejection of the unmodeled elements of the dynamics. Robustness of the closed-loop control system (against external perturbation) and its relation to energy consumption is discussed here. A model of a planar manipulator is used in the conducted case study as an exemplary plant. Conclusions are supported with results obtained with numerical simulations.


Non-Hermitian scattering systems respecting parity-time symmetry exhibit unidirectional invisibility or reflectionlessness at an exceptional point of the scattering matrix. In this study, we investigate the scattering properties of a one-dimensional acoustic parity-time-symmetric multilayered medium. Parity-time symmetry is defined by a spatial small-amplitude square-wave modulation of the medium parameters in the complex plane. Such a multilayered medium has been demonstrated to reach an exceptional point and support unidirectional invisibility for balanced real and imaginary part modulations of the refractive index. Through the analysis of interference within the medium, we show that the complex modulation of acoustic impedance instead of the refractive index governs the exceptional point of the scattering matrix and determines the occurrence of the unidirectional invisibility. This unidirectional invisibility is further investigated for more general cases of complex parameter distribution including unequal modulation amplitudes and rectangular wave modulation. Our study provides an intuitive physical picture of the occurrence of unidirectional invisibility induced by an exceptional point in acoustic wave systems. Moreover, this study could facilitate the design and practical realization of acoustic parity-time-symmetric structures.


A gender gap strongly favoring women is occurring in higher education throughout the Arctic and is especially severe among indigenous groups. This study documents the size, nature, and recent increase in the gender gap at the University of Alaska, especially for Alaska Native students. To our knowledge, this is the first study to provide statistical documentation of this phenomenon. We find that among Alaska Natives, women are earning bachelor's degrees at almost three times the rate of men and associate degrees at almost five times the rate of men. Furthermore, the gender gap in favor of females widened between 1998 and 2004, the most recent year for which we have information. The experience at the University of Alaska shows that increasing access and providing college preparation and support services alone are not enough to engage indigenous young men in postsecondary education. What may also be needed are ways of making education more compatible with traditional male cultural roles and community values. The Community Trades Technology Program at the University of Alaska has succeeded in enrolling large numbers of young Native men in a postsecondary program through such an educational model. The program 1) is located in the students' home community; 2) offers cohort-based instruction that enrolls most of the students' friends; 3) emphasizes practical, hands-on knowledge and the lore of the trade; 4) embeds academic instruction in practical tasks, such as writing letters about construction supplies; 5) connects the educational program to immediate employment in construction projects scheduled for the community; and 6) provides practical help to people, such as doing home repairs, without charge.


The problem of randomly distributed disks is considered in the dilute regime in a two-dimensional domain. Disks are allowed to overlap and to form clusters which may be isolated or percolating. Depending on the number and size of the disks, distribution functions are obtained for different size and bond configurations of clusters. A statistical geometrical approach is taken to derive analytical probabilities for cluster formation in systems, where a maximum of four overlapping disks is considered. Monte Carlo computations are carried out to verify our theoretical approach which is shown to be in close agreement with numerical simulations.The problem of randomly distributed disks is considered in the dilute regime in a two-dimensional domain. Disks are allowed to overlap and to form clusters which may be isolated or percolating. Depending on the number and size of the disks, distribution functions are obtained for different size and bond configurations of clusters. A statistical geometrical approach is taken to derive analytical probabilities for cluster formation in systems, where a maximum of four overlapping disks is considered. Monte Carlo computations are carried out to verify our theoretical approach which is shown to be in close agreement with numerical simulations.


This article derives seven ethno-geographical clusters comprising ethnic societies with similar histories, regional settlements and common kinship lineage arrangements. The procedure reveals the origin of social diversity in Zambia. To explore the usefulness of these clusters, we apply population counts to explain the genesis of the seven 'official' languages from several Zambian languages. Comparing and contrasting ethno-geographical clusters reveals features underlying ethnic similarities and differences in Zambia. We resolve that common origin and migrations that occurred between the twelfth and nineteenth century define ethnic distinctions in Zambia. These characteristics provide a lens through which we can place and analyze current social, linguistic, political, and demographic forces. Compared to provincial administrative regions, ethno-geographical clusters are useful units-of-analysis for comparing ethnic differentials in Zambia.


Young Tokelau children living in New Zealand are members of one of the smallest linguistic minorities in the country. Many speak the Tokelau language at home, and so their first sustained contact with the English language comes when they enter the school system at the age of five. The research reported in this study was designed to investigate two questions associated with the language education of these children during their first two years at school: (a) is it desirable to discourage continued use of the Tokelau language, and (b) how should the schools approach the task of teaching the children English? The English language skills, both formal and functional, of Tokelau children aged five and seven were investigated. Tests were constructed to assess control of English vocabulary and structure and ability to communicate in English with peers and with teachers. Two groups of native speakers of English, each the same age as the Tokelau groups, were also tested. The results indicate that the English language skills of the Tokelau children are not as well developed as those of native speakers of the same age, both when they enter school and after two years of consistent contact with English. The relevance of questions concerning their language education is thus established. Correlations between ratings of Tokelau language skills and scores obtained on the measures of English language skills indicate that, in general, the continued use of the Tokelau language has little effect on the acquisition of English as a second language. The data, however, suggests that there is some relation between the ability to speak Tokelau and both the acquisition of English vocabulary and the efficiency of communication between five year old inter-ethnic pairs in which Tokelauans are the speakers and native-speakers of English are the listeners. These results are considered within the framework of the diglossic relations that exist between English and Tokelau in New Zealand. A detailed examination of the scores obtained on the English language measures by both Tokelau speakers and native speakers of English indicates that the sequence and process of second language acquisition is substantially the same as that of first language acquisition. There is little evidence of transference by the Tokelau speakers from their knowledge of their native languages to the task of understanding English. This is seen as tentative support for the experiential approach currently followed in New Zealand infant rooms. There is however some indication that early help with English vocabulary may be useful. The significance of these results is considered in the light of information derived from three studies that were complementary to the main research. These studies covered such areas as the relation between home language use and the development of second language skills, factors contributing to communicative success, and the implications of the research for language testing. Some recommendations for the language education of young Tokelau children are offered.


Manuscript type: Research paper Research aims: This study aims to shed light on the factors that facilitate online purchase of perfume. It specifically: 1) explores the antecedents of online purchase behaviour in the case of experience goods; 2) analyses the motivations, perceived benefits and perceived risks associated with online purchase of perfume; and 3) identifies perfume e-shoppers' profiles. Design/Methodology/Approach: A qualitative research approach involving interviewing 27 perfume e-shoppers from Brazil, Iran and Portugal was adopted. Research findings: The findings of this study reveal that there are three types of perfume e-shoppers: 1) experienced e-shoppers, 2) bargain e-seekers, and 3) expert e-shoppers. Competitive prices, enjoyable online experiences and greater varieties of perfumes are among the perceived benefits that motivate the online shoppers. The inability to test the perfumes, particularly those that are never tried before, appears to be the major drawback. Theoretical contribution/Originality: This study provides interesting cues on a topic that has so far been disregarded by the literature despite its growing importance as a business sector—online purchase of perfumes. It offers the categorisation of three e-shopper profiles, based on consumers' narratives, and highlighted the importance of further addressing the dynamic nature of consumer behaviours, particularly in the online context. Practitioner/Policy implications: The findings show that the main trigger of buying perfume online is the price discounts, which is particularly important to less experienced Web shoppers. This indicates that experience goods such as perfume should, at the initial stage, be sold in stores that offer an assortment of products. Online perfume stores should consider alternatives to provide perfume testing. Research limitation/Implications: Purposive sampling does not allow results' generalisation; hence future research is needed to further validate the findings.


Corporate Philanthropy (CP) has become increasingly important as a means of filling gaps in the provision of social services using Public-Private partnerships. Very little research exists on determinants and motives of CP in Pakistan. This paper utilizes data from the 2001-2011 Annual Reports of 234 firms listed on the Karachi Stock Exchange (KSE) to analyze the association of CP with different firm specific factors like firm size, firm visibility, labor intensity, firm's financial position (measured as profitability, leverage, cash and equivalent balance, and dividend payout), and the impact of natural disasters on CP. Because this is the first study on this data set, we have employed exploratory data analysis techniques and carefully consider the impact of outliers and other non-standard features of the data. We have used Panel data analytic techniques as well as the Tobit model to analyze the associations between different firm specific factors and CP. We found that firm size, prior profitability, and natural disaster have significant positive impact on CP. We found no evidence that firms are using philanthropy for image creation. Furthermore, exploratory data analysis shows that there are some clusters of firms, which behave differently. Standard regression analysis techniques cannot deal with such cases that require more sophisticated treatment.


A 33-year-old man presented with aneurysmal subarachnoid hemorrhage from a ruptured, blister-type sidewall internal carotid artery (ICA) aneurysm. Balloon-assisted coiling was performed with residual neck. He subsequently developed severe vasospasm requiring intra-arterial therapies on multiple occasions, during which it was noted that despite widespread vasospasm, a focal segment of the ICA at the site of the aneurysm showed no significant spasm, suggesting underlying vessel abnormality. He was discharged without deficit and scheduled for flow diversion given concern over this potentially pathologic segment of vessel. At time of scheduled flow diversion 6 weeks later, a de novo unstable-appearing 6 mm stalk-like pseudoaneurysm was identified in this segment. Both aneurysms and the diseased vessel were successfully treated with Pipeline stenting, with excellent clinical and angiographic result. This case highlights the need for close angiographic follow-up when there is a heterogeneous vasospastic response in arterial segments adjacent to a ruptured aneurysm.


Considerable effort has been invested in the development of effective emotion and behavior recognition techniques. In comparison, little work has been devoted to technologies that can be used to induce specific emotional and behavioral responses, with most such research relying on the presentation of video or images. In this article, we propose a novel technique for the elicitation of emotion based on audio-tactile stimulation. Taking advantage of the relationship between tickling, laughter and emotional states, we conducted an experiment to map the perception of the tickle sensation as a function of vibrotactile stimulation frequency, quantify the effect of hearing laughter stimulus on the perceived intensity of the tactile experience, and assess the potential of the proposed multimodal approach to induce observable mirthful responses. Experimental evidence shows that the perceived intensity of the auditory laughter stimulus has a repeatable scaling effect on the tickle sensation and that the proposed audio-tactile stimulation is a promising approach to laughter elicitation. These findings may inform the design of future multimodal affective interfaces by allowing a more informed prediction of induced emotional and behavioral responses.


Self-management support for people with dementia is important to help them and their family caregivers to cope with challenges in daily live. Insight into the effects of self-management support interventions on people with dementia is however lacking, despite existing relevant systematic reviews. We therefore conducted a meta-review of relevant systematic reviews, following the PRISMA statement. Systematic literature searches were conducted in PubMed, CINAHL, the Cochrane Library, Embase and PsycINFO. The searches were done in December 2015, and all relevant references until then were taken into consideration. No conclusions about the effects of self-management support interventions on people with dementia could be drawn. Recommendations for future research and practice include that self-management support interventions and effect measurements should be wider in scope than psychological well-being.


A comprehensive 3D discrete dislocation dynamics model for Ni-base single crystal superalloys was used to investigate the influence of excess volumes induced by solute atoms Re and W on dislocation motion and creep under different tensile loads at 850 ° C. The solute atoms were distributed homogeneously only in γ matrix channels. Their excess volumes due to the size difference from the host Ni were calculated by density functional theory. The excess volume affected dislocation glide more strongly than dislocation climb. The relative positions of dislocations and solute atoms determined the magnitude of back stresses on the dislocation motion. Without diffusion of solute atoms, it was found that W with a larger excess volume had a stronger strengthening effect than Re. With increasing concentration of solute atoms, the creep resistance increased. However, a low external stress reduced the influence of different excess volumes and different concentrations on creep.


You're waiting at the station for your train and you glance at the electronic poster next to you. It notices that you're looking at it, and from your gaze it works out what you would most like to see. The display changes to show you new brands of mobile phone, and then changes again to show handheld computers as it notices your gaze flicker. You glance at the clock and so it brings up a list of forthcoming trains, then zooms in on yours and shows you exactly how long it will take to arrive. It's as though it's reading your mind – but really it's reading your eyes.


ABSTRACT Electoral turnout in Iraq is a puzzling phenomenon. Despite the country's lack of a democratic past, undeveloped party system, volatile political alliances, inexperienced voters, ethnic politics, sectarian violence, and terrorism, Iraqis' electoral engagement has reached impressive levels. Given the importance of political participation at the foundational stages of democracy, this article places the individual within a broad context to draw an image of the likely Iraqi voter using five nationally representative surveys covering the three Iraqi parliamentary elections of 2005, 2010, and 2014. The main findings indicate that the Iraqi voter is likely to be a middle-aged, educated male with interest in politics and trust in the political institutions. Surprisingly, the socioeconomic and ethnic identities of the voter are not related to that individual's decision to participate. Provincial-level violence has a complex and unstable link to individual turnout, depending on its timing, scale, and frequency, but it does not hinder participation. These results challenge some of the common themes in the literature on Iraqi politics and democratization. With the alarming decline in the turnout rate of the 2018 elections, this study is a preliminary guide to understanding how to sustain citizens' engagement in new democracies.


Theory and empirical evidence suggest that spatial and temporal variation in propagule availability can have as great or greater an influence on community structure as post-recruitment biotic interactions, a phenomenon known as supply-side ecology. One of the first theories to invoke supply-side dynamics, D. Rabinowitz's Tidal Sorting Hypothesis (TSH), attributed the tidal zonation of mangrove tree species to the interacting effects of water depth and propagule size on dispersal and establishment. According to the TSH, smaller propagules are carried farther inland by flood tides than larger ones, stranding and establishing in greater numbers at upper tidal elevations. In contrast, larger propagules are better able to establish in deeper, more seaward areas because their size affords greater access to the soil surface and resistance to buffeting by moving water. Here we present results of the first comprehensive investigation of the TSH. In a series of experiments conducted at Punta Galeta on the Caribbean coast of Panama, we quantified patterns of propagule dispersal and establishment of the three dominant species: Avicennia germinans, Laguncularia racemosa, and Rhizophora mangle. To measure dispersal patterns, we monitored movements (directions and distances) of marked propagules released at three elevations along each of three transects. On all transects, regardless of species or elevation, propagules moved seaward rather than being carried inland by tides, as predicted by the TSH. Rates of seedling establishment were monitored in experiments conducted at different tidal elevations. Contrary to the TSH, all three species established best in the lower intertidal, where they were in prolonged contact with the soil surface during low tides, and established more poorly in the upper intertidal basin, where standing water made rooting difficult. Seedling establishment was lowest in the wave-exposed, back reef habitat, but in accordance with the TSH, the large propagules of Rhizophora rooted and persisted better in this turbulent habitat than did the smaller propagules of the other species. We conclude that the TSH does not explain the vertical distributions of mangrove species on Punta Galeta. Rather, a different form of supply-side dynamics imposed by the strong seaward movement of dispersing propagules is important in structuring our study forests.


Triterpene glycosides are a large, diverse class of amphipathic plant-derived natural products that have high potential as medicinal, agricultural and industrial products.
Currently their use is limited as they are typically produced in small amounts in plants and they are difficult to extract or chemically synthesise.

In this thesis, two glucosyltransferases from oat (Avena strigosa) required for the biosynthesis of the trisaccharide sugar chain of the antifungal triterpene glycoside, avenacin A-1, were identified. A candidate UDP-glucose dependent glycosyltransferase, AsUGT91, was identified by mining an oat root transcriptome database, phylogenetic analysis and expression profiling. In vitro assays and transient expression in Nicotiana benthamiana confirmed triterpene 3-O-arabinoside b-1,2- glucosyltransferase activity.

The triterpene 3-O-arabinoside b-1,4-glucosyltransferase, AsTG, was identified by physical linkage to the avenacin genes, which are clustered in the oat genome. AsTG is a vacuolar transglucosidase in glycosyl hydrolase family 1 (GH1) and is the first of this class of enzyme to be involved in triterpene biosynthesis.

Subsequent analysis of oat mutants revealed that AsUGT91 and AsTG correspond to loci required for avenacin glycosylation. Both sets of mutants have root developmental defects, are deficient in avenacin production and show increased susceptibility to the take-all fungal pathogen, Gaeumannomyces graminis var. tritici.

This work increases the range of glycoside glycosyltransferase activities available to create novel triterpene glycosides by synthetic biology; contributes towards engineering resistance in other crop species to the agriculturally important root disease, 'take-all'; and expands the knowledge of triterpene glycoside biosynthesis to include an unusual class of plant specialised metabolite glycosyltransferases.


Recent research has demonstrated the strong performance of hidden Markov models applied to information extraction—the task of populating database slots with corresponding phrases from text documents. A remaining problem, however, is the selection of state-transition structure for the model. This paper demonstrates that extraction accuracy strongly depends on the selection of structure, and presents an algorithm for automatically finding good structures by stochastic optimization. Our algorithm begins with a simple model and then performs hill-climbing in the space of possible structures by splitting states and gauging performance on a validation set. Experimental results show that this technique finds HMM models that almost always out-perform a fixed model, and have superior average performance across tasks.


The American Association of Diabetes Educa tors combines a diversity of professions and practices in its membership. To focus on the spe cial contributions of each discipline a common diabetes management or educational problem will be addressed periodically, using u team app roach.


Ab initio calculations are used to construct an analytical many-body potential for Pb(2+)He(n) and Pb(+)He(n) clusters which accounts for non pairwise additive interactions. The potential surface reproduces the global minima for cluster sizes ranging from n = 1 to n = 16 obtained from explicit ab initio calculations and found in a previous search for ultrahigh coordination numbers. Ground state energies and structures obtained by accurate diffusion quantum Monte Carlo calculations are used to investigate if quantum effects qualitatively affect the formation of coordination shells. For Pb(2+) doped clusters a first solvation shell is closed at n = 12 and gradually softened by additional helium atoms which start to form a distinct second shell only at n = 16. Spin-orbit coupling profoundly influences the structure of Pb(+)He(n) clusters and causes a gradual structural evolution without pronounced solvation shells.


Ramadi city is suffering from severe flood problems during rainfall season as in many cities in developed countries. Storm Water Management Model (SWMM) was used to simulate storm sewer network in the study area and depending on design rainfall intensity of 9.6 mm/hour. The rainfall intensity was proposed to increased by two to three times of the design intensity because of the absence of metrological stations in the study area to record rainfall intensity data of the rain storm. The intensity increasing by three times led to maximizing the flood risk by 43%. The proposed management to overcoming this problem is linking the collateral lines in Al-Andalus and Alhoz suburbs by additional pipes, this method reduces the percentage of flooding to 31%. Moreover, Economic Indicators (EI) were suggested to evaluate the cost of the network development. The area index ( ) which represents the total cost of the added pipes to the total area of the suburb, and the longitudinal index ( ), which represents the total cost of the added pipes to the length of the main pipe, the magnitudes of these indexes are 178 US dollar/hectare, and 57 US dollar/m respectively.


Today's health-care professionals practice in a highly technological, multidisciplinary environment. In order to provide safe, effective, and high-quality patient care, collaboration is required among all professionals. Traditionally each profession has operated independently in regard to continued professional development. The purpose of this study was to assess practicing registered nurses' readiness toward interprofessional learning in order to align learning with current practice. Method. An ex post facto study design was used to gather data to examine if there is a relationship between variables of demographics and readiness for interprofessional learning. The Readiness for Interprofessional Learning Scale (RIPLS) assesses the readiness for shared learning activities within the context of teamwork and collaboration, sense of professional identity, and patient-centeredness. Descriptive statistics, factor analysis, correlation and multiple regression were used to describe and examine the statistical relationship between variables. Results. Data from 69 registered nurses from a local community hospital were used to calculate descriptive statistics, correlations, factor analysis, and multiple linear regressions. Descriptive data showed the participants had a mean age of 47.5 and were primarily female (94.0%). The average length of years employed in the work force was 11-20 years. Nursing was the primary degree (94.0%) and nurses with other degrees (18.0%). The participant's levels of education ranged from a diploma in nursing (13%), associate degree (43%), bachelor's degree (27%), master's degree (11%), and a doctorate in Nursing Practice (1%). Factor analytics were run on the 23-question instrument. The instrument factor analysis supported the measured constructs as identified by the authors that the RIPLS measures readiness for interprofessional learning. However, a fourth factor, which was called shared learning, did emerge as a factor to consider. Significant correlational findings include a positive relationship of nurses with a master's degree with the learning factor and professional identity and a negative relationship with nurses having an associate degree with professional identity and the learning factor. A bachelor's-prepared nurse had a positive relationship with the professional identity factor. In conducting a multiple regression to test if a selected set of demographic variables predicts teamwork and collaboration, patient centeredness, professional identity, and RIPLS scores, nurses working on medical surgical units exhibited a pattern of significance in professional identity, patient-centeredness, and scores on the RIPLS instrument. No other select set and tested demographic variables predicted or accounted for unique variance. Conclusions. The major finding of this study provides an understanding of which demographic variables in registered nurses may relate to and which demographic variables may predict a readiness for interprofessional learning in the context of continuing professional development. In addition, the estimates of reliability of the RIPLS demonstrated good psychometrics properties and indicated that this may be a good measure of readiness for interprofessional learning.


An experiment was conducted to evaluate the effects of pasture finishing versus feedlot finishing, over time, on fatty acid metabolism in Angus crossbred steers (n = 24). Ruminal fluid, serum, and adipose tissue biopsies were obtained on d 0, 28, 84, and 140. Pasture forages and diet ingredient samples were obtained at 14-d intervals to determine nutritive value and fatty acid composition. The feedlot diet consisted of corn silage, cracked corn grain, soybean meal, and a vitamin and mineral supplement. The pasture-finished steers grazed sequentially on triticale (x Triticosecale rimpaui)/annual ryegrass (Lolium multiflorum), alfalfa (Medicago sativa)/orchardgrass (Dactylis glomerata), and a cool-season grass/legume mixture. The feedlot diet contained an average of 57% of total fatty acids as linoleic acid and 2% as linolenic acid. The pasture forages contained 9% of total fatty acids as linoleic acid and 66% as linolenic acid. Concentrations (% of total fatty acids) of linolenic acid were greater (P < 0.05) in ruminal fluid, serum, and adipose tissue of the pasture-finished steers, compared with the feedlot-finished steers. Concentrations (% of total fatty acids) of cis-9, trans-11 CLA were greater (P < 0.05) in adipose tissue of the pasture-finished steers than feedlot-finished steers. Concentrations of cis-9, trans-11 CLA in adipose tissue declined (P < 0.05) in the feedlot-finished steers from d 0 to 28 to 84. In the pasture-finished steers, concentrations of cis-9, trans-11 CLA in adipose tissue (mg/g of tissue) peaked (P < 0.05) on d 28 and remained elevated (ranged from 9.91 to 12.80 mg/g of tissue) throughout the duration of the study. In the pasture-finished steers, linolenic acid concentrations tended to peak (P = 0.07) on d 28 and remained elevated (ranged from 0.64 to 0.80% of total fatty acids) throughout the study. It appears that only a short time is needed to alter the n-3 and CLA composition of adipose tissue in cattle finished on pasture.


Background The clinical and epidemiological implications of using ambulatory blood pressure monitoring (ABPM) for the diagnosis of hypertension have not been studied at a population level in sub‐Saharan Africa. We examined the impact of ABPM use among Kenyan adults. Methods and Results We performed a nested case–control study of diagnostic accuracy. We selected an age‐stratified random sample of 1248 adults from the list of residents of the Kilifi Health and Demographic Surveillance System in Kenya. All participants underwent a screening blood pressure (BP) measurement. All those with screening BP ≥140/90 mm Hg and a random subset of those with screening BP <140/90 mm Hg were invited to undergo ABPM. Based on the 2 tests, participants were categorized as sustained hypertensive, masked hypertensive, "white coat" hypertensive, or normotensive. Analyses were weighted by the probability of undergoing ABPM. Screening BP ≥140/90 mm Hg was present in 359 of 986 participants, translating to a crude population prevalence of 23.1% (95% CI 16.5–31.5%). Age standardized prevalence of screening BP ≥140/90 mm Hg was 26.5% (95% CI 19.3–35.6%). On ABPM, 186 of 415 participants were confirmed to be hypertensive, with crude prevalence of 15.6% (95% CI 9.4–23.1%) and age‐standardized prevalence of 17.1% (95% CI 11.0–24.4%). Age‐standardized prevalence of masked and white coat hypertension were 7.6% (95% CI 2.8–13.7%) and 3.8% (95% CI 1.7–6.1%), respectively. The sensitivity and specificity of screening BP measurements were 80% (95% CI 73–86%) and 84% (95% CI 79–88%), respectively. BP indices and validity measures showed strong age‐related trends. Conclusions Screening BP measurement significantly overestimated hypertension prevalence while failing to identify ≈50% of true hypertension diagnosed by ABPM. Our findings suggest significant clinical and epidemiological benefits of ABPM use for diagnosing hypertension in Kenyan adults.


Context. Observations show that small-scale vortical plasma motions are ubiquitous in the quiet solar atmosphere. They have received increasing attention in recent years because they are a viable candidate mechanism for the heating of the outer solar atmospheric layers. However, the true nature and the origin of these swirls, and their effective role in the energy transport, are still unclear.
Aims. We investigate the evolution and origin of chromospheric swirls by analyzing numerical simulations of the quiet solar atmosphere. In particular, we are interested in finding their relation with magnetic field perturbations and in the processes driving their evolution.
Methods. The radiative magnetohydrodynamic code CO5BOLD is used to perform realistic numerical simulations of a small portion of the solar atmosphere, ranging from the top layers of the convection zone to the middle chromosphere. For the analysis, the swirling strength criterion and its evolution equation are applied in order to identify vortical motions and to study their dynamics. As a new criterion, we introduce the magnetic swirling strength, which allows us to recognize torsional perturbations in the magnetic field.
Results. We find a strong correlation between swirling strength and magnetic swirling strength, in particular in intense magnetic flux concentrations, which suggests a tight relation between vortical motions and torsional magnetic field perturbations. Furthermore, we find that swirls propagate upward with the local Alfvén speed as unidirectional swirls driven by magnetic tension forces alone. In the photosphere and low chromosphere, the rotation of the plasma co-occurs with a twist in the upwardly directed magnetic field that is in the opposite direction of the plasma flow. All together, these are clear characteristics of torsional Alfvén waves. Yet, the Alfvén wave is not oscillatory but takes the form of a unidirectional pulse. The novelty of the present work is that these Alfvén pulses naturally emerge from realistic numerical simulations of the solar atmosphere. We also find indications of an imbalance between the hydrodynamic and magnetohydrodynamic baroclinic effects being at the origin of the swirls. At the base of the chromosphere, we find a mean net upwardly directed Poynting flux of 12.8 ± 6.5 kW m−2, which is mainly due to swirling motions. This energy flux is mostly associated with large and complex swirling structures, which we interpret as the superposition of various small-scale vortices.
Conclusions. We conclude that the ubiquitous swirling events observed in numerical simulations are tightly correlated with perturbations of the magnetic field. At photospheric and chromospheric levels, they form Alfvén pulses that propagate upward and may contribute to chromospheric heating.


Sutton, J.C., Aina, A.O., and Glazebrook, C.M.

Previous research found that congruent exogenous auditory cues biased and enhanced goal-directed reaching in a multi-target task. The current study assessed if endogenous auditory cues, that require voluntary shifts in attention, can similarly be used to effectively capture attention when performing a multi-target reaching task.
Eleven right-handed individuals (mean age 22.2 years; 5 males) with normal or corrected-to-normal vision and hearing, performed a rapid multi-target reaching task towards four 4cm square targets displayed on a touch screen (Dell ST2220T). Three endogenous auditory cues (no sound, valid and invalid) were randomized. An Optotrak 3D Investigator (NDI) was used to measure reach trajectories at 500Hz.
Following a variable fore-period (300-850ms) the target array turned green, which was the visual signal for participants to begin moving. Upon movement initiation, an auditory cue (0Hz, 250Hz, or 1250Hz) was emitted and one of four equiprobable visual targets was identified. Participants were asked to quickly and accurately continue their reach to the identified target.
Performance measures and movement trajectories were analysed using repeated measures ANOVAs (3 Cue X 4 Target and 3 Cue X 4 Target X 5 Movement Proportion, respectively). Reaction time was significantly shorter in the valid condition. Movement trajectory deviations between upper and lower targets became significant at 60% of movement time, regardless of the auditory cue. Thus, the present results do not support the same advantage of cue-target congruency for endogenous auditory cues that was observed previously for exogenous auditory cues.Acknowledgments: The Funding for this project was provided by Natural Sciences and engineering research council of Canada.


This study is about researching DongEuiBoGam by analysing with pattern identification of modern Traditional Korean medical patholgy as more logical, systematic and standardized theory. Disease pattern mechanisms of essence, spirit, qi and blood in NaeGyungPyeb of DongEuiBoGam are these. In Essence, this explain mechanism of disease patterns those are seminal emission, dream emission, spermatorrhea, white ooze. These disease pattern"s mechanisms are kidney yang deficiency, kidney yin deficiency, heart yang deficiency, heart yin deficiency, heart qi deficiency, spleen qi deficiency and so on. On viewpoints of viscera and bowels they are related with heart, kidney, spleen. And most of them are deficiency from deficiency-excess Pattern Identification. Classifying disease pattern of qi is about upward, downward movement and more concentrated deficiency than excess pattern. Fright palpitations can be classified heart deficiency with timidity, heart blood and qi deficiency, heart qi deficiency, heart blood deficiency, heart qi movement stagnation, water qi intimidating the heart, phlegm-fire harassing the heart, phlegm clouding the pericardium, and so on. Palpitations can be classified heart blood deficiency, heart yin deficiency, heart deficiency with timidity, heart spleen blood deficiency, spleen qi deficiency, phlegm-fire harassing the heart, intense heart fire, and so on. Forgetfulness can be classified heart spleen blood deficiency, heart spleen qi deficiency, kidney essence deficiency, heart qi deficiency, non-interaction between the heart and kidney, etc. for deficiency pattern, phlegm clouding the pericardium for excess pattern. In Blood just say inside bleeding pattern"s category, there are nose bleeding, flopping syncope, qi counterflow, blood vomiting, hemoptysis, spitting of blood, bloody stool, hematuria, and so on. Like these, this study identify pattern of disease in DongEuiBoGam by mechanism of disease theory.


OBJECTIVE
Transseptal suture-assisted septoplasty and coblation are two techniques that can effectively treat septal deviation and inferior turbinate hypertrophy without the need for post-operative packing. In the existing literature, however, the early post-operative symptoms and surgical outcomes of the combination of these 2 procedures have not been addressed.

METHOD
This retrospective study included 65 patients who underwent concomitant nasal septoturbinoplasty. The patients were divided into two groups: the transseptal suture-assisted septoplasty and inferior turbinate coblation group (no-packing group: 33 patients) and the conventional septoturbinoplasty group with merocel packing (packing group: 32 patients). The post-operative symptoms within 14 days, complications and surgical outcomes at 3 months after surgery were recorded and analyzed.

RESULTS
The patients in the no-packing group experienced less nasal obstruction on the first, second and third days post-operatively than those in the packing group (P < 0.000, P < 0.000, and P = 0.043, respectively). The patients in the no-packing group also had less nasal bleeding (P = 0.000 and P = 0.001), dry mouth sensation (P = 0.016 and P = 0.034) and swallowing disturbance (P = 0.013 and P = 0.012) on the first and second days post-operatively, respectively. In terms of orbital symptoms, the patients in the packing group had more severe epiphora (P = 0.031) and swelling sensations (P = 0.040) on the first day post-operatively.

CONCLUSIONS
Transseptal suturing and coblation-assisted septoturbinoplasty can be considered to prevent packing-related comorbidities and reduce post-operative discomfort.


The knowledge of the composition and physical state of the surface of Titan has greatly improved in the last two years thanks to the various in-situ measurements of the Huygens probe (DISR, SSP, GCMS, . . . ) and the remote observations by several of the Cassini instruments (ISS, VIMS, SAR, . . . ), but also by ever powerful ground-based imagery and spectroscopic observations. Our understanding of the role of the surface and sub-surface in the physical and chemical cycles of the atmospheric species and aerosols has changed accordingly. Many old questions on these topics have been reformulated since the time of the oceanic view of Titan, new answer have been proposed but also several new problems have emerged from the data. In this solicited talk I will review the recent results on Titan's surface composition, physical state and distribution and will address their links with the atmospheric composition (gas, condensates, aerosols) and chemistry : do they provide a coherent view of Titan's surface and atmosphere system ? I will emphasize the role the surface materials (ices, simple and macromolecular organics, hydrocarbon liquids, . . . ) play, or may play, in the physical and chemical cycles of the atmospheric species. To conclude I will list some important open questions in this field that should be addressed by future observations, numerical models or laboratory experiments.


Abstract. Using new high accuracy Light Detection and Ranging elevation data we generate coastal flooding maps for Norway. Thus far, we have mapped ~ 80 % of the coast, for which we currently have data of sufficient accuracy to perform our analysis. Although Norway is generally at low risk from sea-level rise largely owing to its steep topography, the maps presented here show that on local scales, many parts of the coast are potentially vulnerable to flooding. There is a considerable amount of infrastructure at risk along the relatively long and complicated coastline. Nationwide we identify a total area of 400 km2, 105,000 buildings, and 510 km of roads that are at risk of flooding from a 200 year storm-surge event at present. These numbers will increase to 610 km2, 137,000, and 1340 km with projected sea-level rise to 2090 (95th percentile of RCP8.5 as recommended in planning). We find that some of our results are likely biased high owing to erroneous mapping (at least for lower water levels close to the tidal datum which delineates the coastline). A comparison of control points from different terrain types indicates that the elevation model has a root mean square error of 0.26 m and is the largest source of uncertainty in our mapping method. The coastal flooding maps and associated statistics are freely available, and alongside the development of coastal climate services, will help communicate the risks of sea-level rise and storm surge to stakeholders. This will in turn aid coastal management and climate adaption work in Norway.


In 1978, Berry and Thompson showed that the amount of theta (3-8 Hz) activity in the spontaneous hippocampal EEG predicted learning rate in subsequent eyeblink conditioning in rabbits. More recently, the absence of theta activity during the training trial has been shown to have a detrimental effect on learning rate. Here, we aimed to further explore the relationship between theta activity and classical eyeblink conditioning by determining how the relative power of hippocampal theta activity [theta / (theta + delta) ratio] changes during both unpaired control and paired training phases. We found that animals with a higher hippocampal theta ratio immediately before conditioning learned faster and also that in these animals the theta ratio was higher throughout both experimental phases. In fact, while the hippocampal theta ratio remained stable in the fast learners as a function of training, it decreased in the slow learners already during unpaired training. In addition, the presence of hippocampal theta activity enhanced the hippocampal model of the conditioned response (CR) and seemed to be beneficial for CR performance in terms of peak latency during conditioning, but did not have any effect when the animals showed asymptotic learning. Together with earlier findings, these results imply that the behavioral state in which hippocampal theta activity is absent is detrimental for learning, and that the behavioral state in which hippocampal theta activity dominates is beneficial for learning, at least before a well-learned state is achieved.


Ab initio calculations within the density functional theory formalism are performed to investigate the stability and electronic properties of fluorinated bilayer graphene (bilayer fluorographene). A comparison is made to previously investigated graphane, bilayer graphane, and fluorographene. Bilayer fluorographene is found to be a much more stable material than bilayer graphane. Its electronic band structure is similar to that of monolayer fluorographene, but its electronic band gap is significantly larger (about 1 eV). We also calculate the effective masses around the Γ-point for fluorographene and bilayer fluorographene and find that they are isotropic, in contrast to earlier reports. Furthermore, it is found that bilayer fluorographene is almost as strong as graphene, as its 2D Young's modulus is approximately 300 N m–1.


Internationalisation is central to higher education and international student mobility a significant manifestation of this process. As increasing numbers of students undertake some or all of their education abroad, many partake in foreign language courses at host institutions. This may include learning the language of the host country or one that is used elsewhere.
A key question in this regard concerns potential gaps that may exist between the students' and teachers' expectations regarding the teaching and learning of languages. Approaches to education often differ from country to country and this may include an emphasis on either autonomy-oriented or teacher-centred modes of learning. In the European and Irish context, much attention has been paid to the former, particularly with the development of the Common European Framework of Reference (2001) and the European Language Portfolio. Based on case study findings, this article discusses the role that 'educational baggage', or prior experiences and subsequent expectations of learning, may play in hindering the development of autonomy among international students. It also suggests ways in which the negative impacts of such 'baggage' may be reduced.


Institutional repositories can be a storehouse of the research of an institution. There are many internal and external needs to find, use and report on the entirety or parts of an institution's research output. This paper examines how to harness environmental factors to make an institutional repository the central and authoritative source of the research material output of a university. How to take it from "a place" to put research to making it "the place" and moving it from a nice-to-have service to one with a solid, sustainable future, one that the academic community values, supports and uses rather than sees as yet another administrative burden. A key value of research material is its authoritativeness. Researchers want to be able to say "this is my paper" or "this is the corpus of my research". Research organisations want to be able to say the equivalent for all their researchers. The value of this identification is not just an assertion of authorship. It is also valued because the material can be authoritatively used to feed research discovery services and e-portfolios, fulfil reporting requirements to government and funders, substantiate promotions and back-up grant applications, and assist with benchmarking academic success in any given field. There are also many other uses for a repository.. The UNSWorks repository at the University of NSW will be used as a case study for this paper. The factors that can support the role of a repository as the authoritative source of research output are evaluated. The implications for interoperability with other institutional and external systems are identified, as are the resource implications and how success can be measured. Topic: Planning, development and management of digital libraries Digital library services


The natural mangrove ecosystems along the Northern Coast of Central Java were very limited in extent, even had replanted almost twenty years ago. Naturally, the upper layer of sediment are the latest deposition (superposition). Environmental condition recently are recorded in the top sediment layer, and can be used to reconstruct past condition (the present is the key to the past). The potential use of diatoms to reconstruct palaeoecology is well established. Diatoms are microscopic algae that form siliceous frustules which make them well preserved in sediment. Diatoms and their assemblages are very useful as integrated indicators of environmental changes because their distribution is closely linked to water quality parameters as well as their affinities to several physical habitats. This research was conducted in order to determine the changes of mangrove ecosystem in the Northern Coast of Central Java based on diatom stratigraphy. Sediment samples from mangrove sites were taken from Pekalongan, Brebes, Semarang, Demak and Rembang. Diatom analysis, consist of digestion, preparation, and identification. The diatom stratigraphy was performed by Software of C2 1.5.1. Stratigraphycally, the mangrove ecosystems along the Northern Coast of Central Java were previously more influenced by freshwater rather than the marine sources which dominate today.


Multiscale Genomics (MuG) Virtual Research Environment (MuGVRE) is a cloud-based computational infrastructure created to support the deployment of software tools addressing the various levels of analysis in 3D/4D genomics. Integrated tools tackle needs ranging from high computationally demanding applications (e.g. molecular dynamics simulations) to high-throughput data analysis applications (like the processing of next generation sequencing). The MuG Infrastructure is based on openNebula cloud systems implemented at the Institute for research in Biomedicine, and the Barcelona Supercomputing Center, and has specific interfaces for users and developers. Interoperability of the tools included in MuGVRE is maintained through a rich set of metadata allowing the system to associate tools and data in a transparent manner. Execution scheduling is based in a traditional queueing system to handle demand peaks in applications of fixed needs, and an elastic and multi-scale programming model (pyCOMPSs, controlled by the PMES scheduler), for complex workflows requiring distributed or multi-scale executions schemes. MuGVRE is available at https://vre.multiscalegenomics.eu and documentation and general information at https://www.multiscalegenomics.eu. The infrastructure is open and freely accessible.


The Java Compiler Compiler is a tool for developing applications using Java. JavaCC is freely available and generates Java source code. Language processors that the tool generates thus derive the benefit of the language's platform independence. We walk through the process of using JavaCC to create language-enabled applications. This requires introducing us to Extended Backus Naur Form, a prerequisite to using JavaCC. EBNF is commonly used to specify the grammar of formal languages, including programming languages. JavaCC has many significant advantages, one of which is that is neatly blends EBNF and Java, making it easy for someone with knowledge of both to quickly exploit JavaCC's power.


A goal of computer system security is to prevent an attack, and authentication mechanisms can prevent a compromise on parts of a system. Most if not all forms of access are granted based on a single authentication scheme, and passwords are currently the most widely used authentication mechanism. Weak passwords have been cited by experts from industry, government, and academia as one of the most critical security threats to computer networks. However, various applications are available today which allow system administrators to assess the strength of their passwords in order to take the necessary precautions. The purpose of this report is to conduct a study of how well some of the more popular password auditing applications perform for Windows and UNIX operating systems.


A new technique for improving the signal reconstruction performance for compressive sensing of gait signals is proposed. The algorithm is based on the minimization of a pseudo-norm which promotes group-block-sparse structure on the first-order difference of the signal. Signal blocks in foot gait signals occur as groups, and the locations of the group are estimated based on the regularization promoting block-sparse structure. The group locations are used for minimizing the pseudonorm for promoting group-block-sparse structure. Simulation results demonstrate that the proposed technique yields upto 0.76dB improvement in the reconstruction performance for foot-gait signals relative to the algorithms promoting block-sparse structure.


OBJECTIVE
To describe an aged persons mental health service in the Sunraysia district in remote Victoria.

CONCLUSION
The aged persons mental health community team undertakes the bulk of the service's work. The data for 2 years are presented and demonstrate how effective the team is. Good relationships and linkages have been built with the local hospital, general practitioners, aged residential care services and the local aged care assessment service. During the 2 year period, very few elderly patients were admitted to the inpatient psychiatric facility and patients suffering from dementia were rarely admitted.


Eosinophils, along with mast cells are key cells involved in the innate immune response against parasitic infection whereas the adaptive immune response is largely dependent on lymphocytes. In chronic parasitic disease and in chronic allergic disease, IL-5 is predominantly a T cell derived cytokine which is particularly important for the terminal differentiation, activation and survival of committed eosinophil precursors. The human IL-5 gene is located on chromosome 5 in a gene cluster that contains the evolutionary related IL-4 family of cytokine genes. The human IL-5 receptor complex is a heterodimer consisting of a unique alpha subunit (predominantly expressed on eosinophils) and a beta subunit which is shared between the receptors for IL-3 & GM-CSF (more widely expressed). The alpha subunit is required for ligand-specific binding whereas association with the beta subunit results in increased binding affinity. The alternative splicing of the alpha IL-5R gene which contains 14 exons can yield several alpha-IL-5R isoforms including a membrane-anchored isoform (alpha IL-5Rm) and a soluble isoform (alpha IL-5Rs). Cytokines such as IL-5 produce specific and non-specific cellular responses through specific cell membrane receptor mediated activation of intracellular signal transduction pathways which, to a large part, regulate gene expression. The major intracellular signal transduction mechanism is activation of non-receptor associated tyrosine kinases including JAK and MAP kinases which can then transduce signals via a novel family of transcriptional factors named signal transducers and activators of transcription (STATS). JAK2, STAT1, and STAT5 appear to be particularly important in IL-5 mediated eosinophil responses. Asthma is characterized by episodic airways obstruction, increased bronchial responsiveness, and airway inflammation. Several studies have shown an association between the number of activated T cells and eosinophils in the airways and abnormalities in FEV1, airway reactivity and clinical severity in asthma. It has now been well documented that IL-5 is highly expressed in the bronchial mucosa of atopic and intrinsic asthmatics and that the increased IL-5 mRNA present in airway tissues is predominantly T cell derived. Immunocytochemical staining of bronchial biopsy sections has confirmed that IL-5 mRNA transcripts are translated into protein in asthmatic subjects. Furthermore, the number of activated CD4 + T cells and IL-5 mRNA positive cells are increased in asthmatic airways following antigen challenge and studies that have examined IL-5 expression in asthmatic subjects before and after steroids have shown significantly decreased expression following oral corticosteroid treatment in steroid-sensitive asthma but not in steroid resistant and chronic severe steroid dependent asthma. The link between T cell derived IL-5 and eosinophil activation in asthmatic airways is further strengthened by the demonstration that there is an increased number of alpha IL-5R mRNA positive cells in the bronchial biopsies of atopic and non-atopic asthmatic subjects and that the eosinophil is the predominant site of this increased alpha IL-5R mRNA expression. We have also shown that the subset of activated eosinophils that expressed mRNA for membrane bound alpha IL-5r inversely correlated with FEV1, whereas the subset of activated eosinophils that expressed mRNA for soluble alpha IL-5r directly correlated with FEV1. Hence, not only does this data suggest that the presence of eosinophils expressing alpha IL-5R mRNA contribute towards the pathogenesis of bronchial asthma, but also that the eosinophil phenotype with respect to alpha IL-5R isoform expression is of central importance. Finally, there are several animal, and more recently in vitro lung explant, models of allergen induced eosinophilia, late airway responses (LARS), and bronchial hyperresponsiveness (BHR)--all of which support a link between IL-5 and airway eosinophilia and bronc


ABSTRACT Much workplace support to parents offered by employers is gender neutral in design, but fathers' usage rates are generally very low and far below that of mothers. This paper reflects on men's dual roles as fathers and employees in relation to formal and informal work policies and practices, with the aim of answering the question: How could fathers feel supported by their work environment to take a more active caregiving role in the lives of their children? We take a capabilities approach to explore models of change, which supports the assumption that many fathers are somehow not fully enabled by their organisations to use policies. Focus groups were conducted within a large public sector organisation in the UK to capture the individual and interactional experiences of fathers. Findings suggest that workplace culture, line manager relationships, the 'modelling' behaviour of peers and gendered leave practices all impact on how fathers feel about using work-family balance policies, and whether they are likely to use them. The limits of workplace support for fathers can be challenged via the consideration of some key institutional conversion factors which if addressed may better enable fathers to exercise greater agency with regard to work-family balance entitlements.


An analytical investigation was conducted to determine the rewetting characteristics of thin, surface tension driven liquid films over heated plates as a function of the fluid properties, the film thickness, and the applied heat flux. Analytical expressions for the maximum sustainable heat flux and the rewetting velocity were developed for both flat and grooved plates and were compared with data from previous investigations. The results indicated good agreement for low film velocities; however, at high velocities the experimental data deviated significantly from the theoretical predictions. It was hypothesized that this deviation was due to the presence of liquid sputtering near the liquid front. To compensate for this liquid sputtering, the expressions for maximum sustainable heat flux and rewetting velocity were modified using an empirical correction factor developed from the data of previous thin film thickness investigations. The resulting modified expressions were found to compare very favorably with available experimental data over a large range of flow conditions and velocities.


In developed countries Capital Asset Pricing Model (CAPM) is the most frequently used model for determination of the cost of equity. On the other hand, there is no consensus about which model would be the most appropriate and easy to use for the estimation of cost of equity in emerging markets.The aim of this research is to analyze on the basis of Estrada's work (2000; 2007) four different risk measures based on standard deviation, beta, downside risk and downside beta, as well as corresponding asset pricing models for capital markets of Slovenia, Croatia and Serbia in order to determine the most appropriate asset pricing model and to estimate the costs of equity for selected markets. It should be pointed out that asset pricing research in general is scarce for selected markets and that similar research was not done for them. Results of the research show that for total selected market the most appropriate risk measure out of four proposed is downside risk, while the model that best explains full sample mean returns contains combination of downside risk and downside beta. Results of the research favor downside risk measure for each selected market. When considering multiple regressions with the highest explanatory power for each selected market, results show that all multiple regressions contain downside risk as a risk variable and beta or downside beta as additional systematic risk variable, indicating one more time importance of downside risk for Slovenian, Croatian and Serbian capital markets.The results show that the average cost of equity estimated on the basis of asset pricing model with downside risk as a risk measure amounts to 20.16% for full sample. The results also indicate that Serbia has the highest cost of equity and that the cost of equity for Slovenian and Croatian capital markets is lower and rather similar.


The open-ended hollow tubular structure formed by inclusion of water molecules in the packing of the hydroxyl acid 1 (R1 = CH2OH, R2 = ethyl groups) led to the synthesis and structural study of their unsaturated analogues. In this article we report on a general and practical large-scale synthesis of hydroxyl acids that possess alkenyl and alkynyl appendages. Substitution of the ethyl groups in 1 with unsaturated two-carbon appendages has a different effect on the molecular structure and on the hydrogen-bonding pattern. No variation has been induced by substitution of only one ethyl group with a vinyl one, although the substitution of both ethyl groups with vinyl or acetylene appendages has the greatest effect on the molecular structure and results in different hydrogen-bonding motifs.


We demonstrate the decoy-state quantum key distribution (QKD) with one-way quantum communication in polarization space over 102 km. Further, we simplify the experimental setup and use only one detector to implement the one-way decoy-state QKD over 75 km, with the advantage to overcome the security loopholes due to the efficiency mismatch of detectors. Our experimental implementation can really offer the unconditionally secure final keys. We use 3 different intensities of 0, 0.2, and 0.6 for the light sources in our experiment. In order to eliminate the influences of polarization mode dispersion in the long-distance single-mode optical fiber, an automatic polarization compensation system is utilized to implement the active compensation.


Obtaining highly sensitive ferromagnetic, FM, and nonmagnetic, NM, multilayers with a large room-temperature magnetoresistance, MR, and strong magnetic anisotropy, MA, under a small externally applied magnetic field, H, remains a subject of scientific and technical interest. Recent advances in nanofabrication and characterization techniques have further opened up several new ways through which MR, sensitivity to H, and MA of the FM/NM multilayers could be dramatically improved in miniature devices such as smart spin-valves based biosensors, non-volatile magnetic random access memory, and spin transfer torque nano-oscillators. This review presents in detail the fabrication and characterization of a few representative FM/NM multilayered films—including the nature and origin of MR, mechanism associated with spin-dependent conductivity and artificial generation of MA. In particular, a special attention is given to the Pulsed-current deposition technique and on the potential industrial applications and future prospects. FM multilayers presented in this review are already used in real-life applications such as magnetic sensors in automobile and computer industries. These material are extremely important as they have the capability to efficiently replace presently used magnetic sensors in automobile, electronics, biophysics, and medicine, among many others.


Background: Digital photographs have become an integral part in plastic and reconstructive surgery. They are significant in clinical research and outcome evaluation. There is a need for effective and secure methods to store, search, and retrieve those photographs. We developed a Health Insurance Portability and Accountability Act compliant searchable database to archive and index clinical information for clinical and research purposes. Methods: At our craniofacial clinic, digital media (2-D, 3-D, and 4-D photographs) are obtained on a regular basis to evaluate and document treatment outcomes. In addition, patients are asked to enroll in our institutional review board (IRB)-approved imaging database. Daily, we link all digital photographs to the patient encounter through EPIC's Media Manager. This allows us to automatically identify and extract new digital media, patient demographics, diagnosis codes, relevant providers, and the text of the clinic notes to our digital database. To search our extensive database, we employed the VIEW search engine. Results: To date, our database contains more than 277 000 images of 11 000 patients where more than 1900 patients are enrolled in the IRB study. This search engine allows full-text search with query response time between 2 and 5 seconds. The search engine displays the returned through a web page interface, which includes image thumbnails and the relevant part of the clinic note. In addition, a patient-specific chart allows the user to examine all patient notes and photographs. Conclusion: Our solution allows providers and researchers to retrieve all digital media securely and efficiently.


Globalization and the knowledge/ information revolution are signalling the advent of a new societal order, one with profound and pervasive implications for citizens, for markets, for governments and, therefore, for public policy. This new global order is a truly remarkable watershed in the annals of human history and, as is the case with all such great transformations, it carries with it both enormous opportunities and daunting challenges. Building on my 1999 Mabel Timlin Lecture at the University of Saskatchewan, I want to share with you my perspectives on the nature of some of these opportunities and challenges, with an eye toward drawing out the implications for the evolution of the Canadian society and economy.


This brief has provided a basic profile of child marriage in Niger. Measures of child marriage are very high. The share of women ages 18-22 who married as children is 76.8 percent and it has not declined substantially over time. The share of girls marrying very early, before the age of 15, has declined more, but not rapidly either. Other measures of child marriage have declined only slowly as well over the last 25 years. Child marriage is associated with lower wealth, lower education levels, and higher labor force participation. These are however only correlations, not necessarily causal effects. Other briefs in this series look at potential causal effects.


A recent ESPN magazine article ["These go to 11," ESPN the Magazine 15 Nov (2010)] ranked the top collegiate basketball arenas according to "noise potential." The top five arenas were listed as Kansas University, Duke University, New Mexico University, Kentucky University, and Florida University. The rankings were established by a team of Penn State Acoustics students using the theory for sound buildup in large rooms, since actual measurements were infeasible. Both diffuse field and direct field contributions of the sound pressure were estimated at center court for octave band frequencies from 125 Hz to 4 kHz. Seating geometries, materials, and other relevant information were collected for each arena and used with estimated absorption coefficients to determine the room constant and critical distance. The diffuse field contributions were then combined with approximate sources terms based on the seating capacity of the arena, the proximity of the fans to the court, and whether they were students. The sound pressures were then combined into a total A‐weighted sound pressure level and used to determine the ranking. The direct and reverberant contributions of each arena were then compared to establish the positive and negative aspects of each arena in terms of noise potential. This comparison reveals how Kansas and Duke reached the top of the ranking, despite having drastically different arena geometry and capacity.


This study sought to develop further understandings of the relationships that people can develop with the voices they hear, and to explore the development of these relationships over time. Qualitative data was gathered from 12 people attending peer support groups. A semi-structured interview was used to facilitate the interviews and analysis of the transcripts was guided by the principles of Thematic Analysis. Four themes emerged and suggested that the relationships between hearers and their voices can have a variable trajectory which is influenced by stress, talking with and about voices, and the acceptance of voices and/or resistance. Clinically, the findings have implications for the training of frontline staff, the provision of peer support and the adaptation of psychological therapies. Future studies should assess whether our findings generalise to more diverse samples of voice hearers and use longitudinal qualitative and quantitative designs to explore change processes in-depth from early to later stages of psychosis.


The purpose of this study was to observe the effect of extender and cooling rate on the quality of frozen thawed semen of Bali bull (Bos sondaicus). The experiment was conducted at Laboratory of Animal Biotechnology, Faculty of Animal Husbandry, Andalas University. A completely randomized design of factorial 2 x 3, 2 different extenders and 3 cooling rates with 3 bulls as the replicate. Data were analyzed using analysis of variance (ANOVA). The first factors was extender such as tris citrate egg yolk (TCEY) and tris citrate soy milk (TCSM). The second factors was the cooling rate such as: 15ºC/min, 10ºC/min and 5ºC/min. Variables were: motility, viability, abnormality, and membrane integrity. The results of treatment of TCEY extender on the average of motility 42.67±5.17%, viability of 53.78±3.79%, abnormality of 18.89±1.07%, and membrane integrity of 35.44±3.01%. The effect of cooling rate of 10°C /min has the highest semen motility of 44.35±5.28%, viability of 57.17±1.18%, abnormality of 17.84 ± 0.23 % and membrane integrity of 36.83±2.12%. The interaction between extender and cooling rate was founded significant different (P<0.05). Otherwise of extender and cooling rate on post-thawed of motility, viability and membrane integrity, had no difference (P>0.05) on semen abnormality. It can be concluded that tris-citrate egg yolk (TCEY) extender with cooling rate of 10ºC / min were the best semen motility, viability, and membrane integrity of spermatozoa.