Abstract Objective: Drug dependency has been typified as a persistent relapsing disorder. Overall, 65% of people with substance use disorders relapse within one year after treatment. Recent interventions have focussed on contextually relevant relapse prevention strategies. This study explored relapse prevention strategies utilised by patients recovering from poly-substance use disorders one year after treatment at a Psychiatric Rehabilitation Unit in Ghana. Methods: The study adopted a descriptive phenomenology design and was conducted at the Psychiatric Rehabilitation Unit of the Regional Hospital, Sunyani, Ghana. A purposive sample of 15 patients recovering from poly-substance use disorders were recruited. Data were collected through in-depth interviews with a semistructured guide and analysed using the content analysis procedures. Results: Five key themes emerged from the analysis of the data that described participants' relapse prevention strategies. These include clinical strategies, self-initiated tactics, spirituality and religious engagements, communalism and social support network. Conclusions: The evidence from this study supports a multilevel treatment strategy for patients with poly-substance disorders. We found that a combination of clinical, individual and contextual factors significantly contribute to relapse prevention efforts in the Ghanaian context. Clinicians and treatment services should explore, evaluate, strengthen and incorporate these emerging themes into their relapse prevention interventions protocols.


Thank you very much for reading folk costumes of the world. Maybe you have knowledge that, people have look hundreds times for their favorite readings like this folk costumes of the world, but end up in infectious downloads. Rather than reading a good book with a cup of tea in the afternoon, instead they juggled with some infectious bugs inside their laptop. folk costumes of the world is available in our digital library an online access to it is set as public so you can download it instantly. Our book servers saves in multiple locations, allowing you to get the most less latency time to download any of our books like this one. Merely said, the folk costumes of the world is universally compatible with any devices to read.


Along with the development of increasingly unstoppable technological advances everyone must think harder to keep up with the times plus the outbreak of the covid-19 virus that changes formal education in online learning. In the current era there are still many people applying for jobs by making written documents in the middle of the digitalization era, especially in the creation of curriculum vitae to apply for jobs. Many things change especially in terms of publication media from print media form to digital form. Non-formal education that exists still does not feel the maximum results in the community. The purpose of this program is to strive to improve the ability to make documents with existing facilities in the community, especially problems in typing and publication. Now there are many platforms that provide media publication of documents for free and this is where the role of students to direct and educate about publication digitally. This program is divided into two sessions, the first is Microsoft Word training to create cover letters, curriculum vitae and certificates and then continued with the creation of One-page site as a publication media. This program is held as many as six times online meetings with zoom meetings. In the implementation of the program participants are led to be able to understand the material provided by making the same thing with the creativity of each result participants are able to make cover letters, curriculum vitae, certificates and also carrd.co website. The results of this program require participants to be able to make a digital job application and publish it into digital media in the form of a website.


Despite the high prevalence of fatty liver disease, the safety of liver resection in settings of steatohepatitis (SH) or hepatic steatosis is poorly understood. The aim of this study was to determine whether underlying SH or simple hepatic steatosis increases morbidity after liver resection. We compared patients undergoing liver resection with underlying SH or greater than 33% simple hepatic steatosis to controls selected for similar demographics, diagnoses, comorbidities, preoperative chemotherapy treatments, and extent of partial hepatectomy. Primary endpoints included postoperative overall and hepatic‐related morbidity. One hundred and two patients with SH and 72 with greater than 33% simple hepatic steatosis who underwent liver resection from 2000 to 2011 were compared to corresponding controls. There were no differences in extent or approach of liver resection, malignant indications, preoperative chemotherapy treatment, elements of metabolic syndrome, alcohol use history, American Society of Anesthesiologists score, age, or gender between patients with SH or simple steatosis and corresponding controls. Ninety‐day postoperative overall morbidity (56.9% versus 37.3%; P = 0.008), any hepatic‐related morbidity (28.4% versus 15.7%; P = 0.043), surgical hepatic complications (19.6% versus 8.8%; P = 0.046), and hepatic decompensation (16.7% versus 6.9%; P = 0.049) were greater among SH patients, compared to corresponding controls. In contrast, there were no differences in postoperative overall morbidity (34.7% versus 44.4%; P = 0.310), any hepatic‐related morbidity (19.4% versus 19.4%; P = 1.000), surgical hepatic complications (13.9% versus 9.7%; P = 0.606), or hepatic decompensation (8.3% versus 9.7%; P = 0.778) between simple hepatic steatosis patients and corresponding controls. Using multivariable logistic regression, SH was independently associated with postoperative overall (odds ratio [OR], 2.316; 95% confidence interval [95% CI]: 1.267‐4.241; P = 0.007) and any hepatic‐related (OR, 2.722; 95% CI: 1.201‐6.168; P = 0.016) morbidity. Conclusion: Underlying SH, but not simple hepatic steatosis, increases overall and hepatic‐related morbidity after liver resection. (HEPATOLOGY 2012)


Recent availability of and interest in distillers dried grains with solubles (DDGS) has resulted from the increased production of ethanol. A study was designed to evaluate secondcycle Bovans White laying hens that were fed varying levels of DDGS. Layer performance, egg characteristics, and consumer acceptability served as evaluation criteria. Hens were fed a commercial diet formulated to contain 0, 8, 16, 24, or 32% DDGS for a period of 15 wk. The varying levels of DDGS did not have adverse effects on any of the parameters measured. The 16% DDGS treatment resulted in significantly higher egg production than the 0, 8, and 24% treatments, whereas the 32% treatment was intermediate and was not significantly different from any other treatment. Inclusion of DDGS in the diet led to a significantly darker (L*) and redder (a*) yolk, with a tendency to increase Haugh unit values (P = 0.03), indicating potentially increased interior egg quality. During taste panels, consumers slightly preferred the eggs derived from DDGS-fed hens over eggs that were obtained from hens fed no DDGS in both the flavor acceptability (P = 0.04) and overall acceptability (P = 0.02) categories, but they liked eggs from all treatments. Based on the results from the present study, DDGS could be included at a rate of up to one-third of a commercial layer diet without any significant detrimental effects on the production or egg characteristics of second-cycle hens.


This research has been carried out to observe the response of minimally processed durian fruit due to the influence of edible coating material formulations and storage time at freezing temperatures. The research was carried out in two stages which were carried out in the Department of Food Technology, Pasundan University from March to July 2005. The experimental design method used in stage 1 was divided plot design (RPPT) with 3 factors repeated twice, carbohydrate source as main plot with levels: pectin, arabic gum and cornstarch, protein source as subplots with levels: gelatin and soy protein isolates, as well as lipid sources: glyceryl monostearate and liquid wax as plot children. Edible film layers formed were analyzed for water vapor transmission rate, tensile strength, elongation percent, thickness and organoleptic testing of color. The experimental design used in stage 2 was a completely randomized design (CRD) with 2 factors repeated four times, namely the formula of edible coating material (with or without edible coating) and storage time (0, 1 and 2 months). The processed durian must be kept for a minimum of 2 months at freezing temperatures of -70 C. The results of the second phase of the study showed that the formula of edible coating material and storage time affected the weight loss, water content, oxygen content and carbon dioxide in the packaging, hardness, total sugar content, vitamin C content, total bacteria and organoleptic tests, but did not affect the pH, total acid, total yeast and mold of durian are minimally processed. The results of the kinetics prediction of the rate of degradation of vitamin C to the minimum processed durian fruit coated with edible coating showed a first-order reaction with a linear equation Y = -0.4517x + 1.9955 and fruit quality could be maintained for 44 days.


Abstract The paper deals with the integrated development in rural areas realized by the LEADER approach. This approach is based on the territorial principle, where the significant role are playing local actors operating in the area, who through their actions influence it's development. The LEADER approach is being implemented through the Axis 4 of the Rural Development Policy. The main objective of the paper is to evaluate the implementation of the LEADER approach in particular Local Action Groups in Slovakia, to identify problems with implementation and to suggest solutions for their elimination. In the paper we evaluate the internal operation of the Local Action Group - the balance of relations between members, defining areas of their mutual cooperation and participation rate in the calls from the perspective of managers of Local Action Groups as well as external relations - relations with Agricultural Paying Agency and ways of influencing the operation of Local Action Groups through legislation. We also focuses on personal views of managers on meeting the needs of the Local Action Group by the projects realized within the Axis 4 LEADER. We also pointed out problems connected with the direction of the Axis 4 in terms of the possibility of funds spending, we defined negative impacts of the legislation as well as particular activities of the Agricultural Paying Agency on Local Action Group's performance.


The National Police has the obligation to execute activities as established under the rule of law, have true stories responsibilities scam designed to ensure a society free environment Inequalities. Existential Dangerous Activities that are configured as exceptional a Object Ranging Risk Analysis Service Through The legal precedent and doctrine. These child activities using firearms, the use of Official Vehicles That cannot be aimed at violating the Rights of Individuals, or place them at risk because they can generate object Damage Compensation that child.


The thesis entitled "Enantioselective Synthesis of Bioactive Molecules via MetalCatalysed Kinetic Resolution of Benzylic Alcohols and Azido Epoxides, αAminoxylation of Aldehydes and Methodology involving Diazidation of Alkenes" is divided into four chapters. The title of the thesis clearly indicates the objective that is to synthesize enantiomerically pure drugs and to interface synthetic organic chemistry for the development of new methodologies. Chapter 1 deals with (–)sparteine/Pd(II) (1)catalyzed oxidative kinetic resolution of α-bromo benzylic alcohols 2a-f and their application in the asymmetric synthesis of (S)-duloxetine 12 and (–)-chloramphenicol 20. Chapter 2 describes an enantioselective synthesis of (R)-rugulactone 33 via D-prolinecatalyzed α-aminoxylation of aldehyde, and asymmetric synthesis of (R)-coniine 42 and formal synthesis of (+)-febrifugine 52 employing Sharpless asymmetric dihydroxylation of dienic ester. Chapter 3 describes the (salen)Co[OC(CF3)3].H2O (53)-catalyzed phenolytic kinetic resolution of benzyloxy epoxides 55a & b to chiral α-aryloxy-α'-benzyloxy alcohols 57a-g and asymmetric synthesis of D-erythro-sphinganine 71 via (salen) Co(III)(OCOCH3) (54)catalyzed hydrolytic kinetic resolution of azido epoxide 62. Chapter 4 deals with the NaIO4–NaN3–mediated diazidation of alkenes 72a-i to 1,2-diazido alkanes 73a-i and Cu(I) catalyzed synthesis of phenyl substituted gem-ditriazoles 75a-f from, α,αdiazido aromatic ketones 74a-f.


Long-term developmental outcome of the prematurely born is generally related to birth weight as a reflection of gestational age: The more immature the infant, the greater the risk of abnormal developmental outcome. Due to improvements in fetal and neonatal care over the past 25 years, developmental outcome of the preterm group has steadily improved, now approaching the expected outcome for term neonates for those born weighing over 1,000 g. For the group of very immature infants (birth weight less than 1,000 g) abnormal developmental outcome remains a significant risk. For any individual preterm infant, long-term developmental outcome is generally related to the severity and duration of initial illness and the postdischarge environment. Specific causation of developmental abnormality in a particular infant is usually speculative. The overall improvement in the long-term outcome for preterm infants has been gained at great cost in medical resources and is accompanied by emotional costs to families that remain unmeasured. The key to further reducing the risk of abnormal developmental outcome remains the prevention of prematurity. Until that can be accomplished, continued meticulous attention to all the details of superb fetal and neonatal intensive care must be exercised to minimize the risk of handicap in this vulnerable group of patients.


This document supports the idea that disability, as a concept and set of values, is a social invention that has been built over time in the "world of life" and has served awkwardly trying to explain what "apparently seems different." We present the results of a hermeneutical research about debates in term of paradigms and models of disability (and evolution), in the context of hiring people with disabilities in the labor market in Latin America. A interpretive methodological approach is used and based on literature research; discovering that two important trends dominate and influence the practices of exclusion of people with disabilities in Latin American labor market: the paradigms and models focused on the "deficiency" (associated with disability as conditioning inherent in the person) and those who are focused on "recognition of diversity and talents development" (associated with disability as extrinsic conditioning to the person). These two trends are developed in this article and a methodological approach is proposed to identify how these trends may influence labor practices in order to avoid exclusion opening lines of future research efforts.


We describe, up to degree equal to the rank, the Lie algebra associated with the automorphism group of a free group. We compute in particular the ranks of its homogeneous components, and their structure as modules over the linear group.
Along the way, we infirm (but confirm a weaker form of) a conjecture by Andreadakis, and answer a question by Bryant-Gupta-Levin-Mochizuki.


In forecasting a variable (forecast target) using many predictors, a factor model with principal components (PC) is often used. When the predictors are the yield curve (a set of many yields), the Nelson–Siegel (NS) factor model is used in place of the PC factors. These PC or NS factors are combining information (CI) in the predictors (yields). However, these CI factors are not "supervised" for a specific forecast target in that they are constructed by using only the predictors but not using a particular forecast target. In order to "supervise" factors for a forecast target, we follow Chan et al. (1999) and Stock and Watson (2004) to compute PC or NS factors of many forecasts (not of the predictors), with each of the many forecasts being computed using one predictor at a time. These PC or NS factors of forecasts are combining forecasts (CF). The CF factors are supervised for a specific forecast target. We demonstrate the advantage of the supervised CF factor models over the unsupervised CI factor models via simple numerical examples and Monte Carlo simulation. In out-of-sample forecasting of monthly US output growth and inflation, it is found that the CF factor models outperform the CI factor models especially at longer forecast horizons.


Leo Marx's 1964 The Machine in the Garden: Technology and the Pastoral Ideal in America was a foundational work in environmental studies. This article discusses the volume's significance and how Marx's ideas have evolved in later essays. Especially noteworthy is Marx's insight into the contradictory relationship with nature embodied in American pastoralism. Americans celebrate nature and rural values and yet embrace industry and commercialism as means to a pastoral utopia, even though these are ultimately destructive of the natural environment. Given these contradictions and the ascendancy of industrial and commercial values, Marx argues that American pastoralism ultimately fails as a viable cultural and political ideal. This article is critical of such pessimism but also shows how, in later essays, Marx revises his prognosis. Marx comes to see the pastoral ideal, particularly as manifested in environmentalism, as offering a key political alternative to contemporary industrial society and its social and ecological pathologies.


We report on the extreme γ-ray activity from the flat spectrum radio quasar (FSRQ) PKS 1510−089 observed by the AGILE satellite in March 2009. In the same period a radio-to-optical monitoring of the source was provided by the GASP–WEBT and REM facilities. In the radio band we made use also of multi-epoch 15-GHz Very Long Baseline Array data from the MOJAVE Program to get information on the parsec-scale structure. Moreover, several Swift target of opportunity observations were triggered, adding important information on the source behaviour from optical/UV to hard X-rays. We paid particular attention to the calibration of the Swift/UVOT data to make it suitable to the blazars spectra. Simultaneous observations from radio to γ rays allowed us to study in detail the correlation among the emission variability at different frequencies and to investigate the mechanisms at work during this high activity state of the source. In the period 9–30 March 2009, AGILE detected γ-ray emission from PKS 1510−089 at a significance level of 21.5-σ with an average flux over the entire period of (311 ± 21) × 10 −8 photons cm −2 s −1 for photon energies above 100 MeV, and a peak level of (702 ± 131) × 10 −8 photons cm −2 s −1 on daily integration. The activity detected in γ rays occurred during a period of increasing activity from near-infrared to UV, as monitored by GASP– WEBT, REM and Swift/UVOT. A flaring episode on 26–27 March 2009 was detected from near-IR to UV, suggesting that a single mechanism is responsible for the flux enhancement observed at the end of March. By contrast, Swift/XRT observations seem to show no clear correlation of the X-ray fluxes with the optical and γ-ray ones. However, the X-ray observations show a harder photon index (Γx � 1.3–1.6) with respect to most FSRQs and a hint of harder-when-brighter behaviour, indicating the possible presence of a second emission component at soft X-ray energies. Moreover, the broad band spectrum from radio-to-UV confirmed the evidence of thermal features in the optical/UV spectrum of PKS 1510−089 also during high γ-ray state. On the other hand, during 25–26 March 2009 a flat spectrum in the optical/UV energy band was observed, suggesting an important contribution of the synchrotron emission in this part of the spectrum during the brightest γ-ray flare, therefore a significant shift of the synchrotron peak.


Given a set of images of a set of 3D points, with known correspondence among them, we would like to reconstruct the coordinates of the 3D points and discover the projection matrices associated with the cameras used to capture these images. Once this information is obtained, we would be able to compute any novel view of these 3D points from a virtual camera placed at any position and orientation. We solve this problem as an optimization problem using the Particle Swarm Optimization (PSO) algorithm.


Assessment of lameness prevalence and severity requires visual evaluation of thelocomotion of a cow. Welfare schemes including locomotion assessments are increasingly being adopted, and more farmers and their veterinarians might implement a locomotion-scoring routine together. However, high within-observer agreement is a prerequisite for obtaining valid mobility scorings, and within-observer agreement cannot be estimated in a barn, because the gait of cows is dynamic and may change between 2 occasions. The objective of this study was to estimate the within-observer agreement according to the observers' educational background and experience with cattle, based on video recordings with very diverse types of gait. Groups of farmers, bovine veterinarians, first- and fourth-year veterinary students, researchers, and cattle-inexperienced sensory assessors evaluated mobility using a 5-point mobility score system developed specifically for walking cows (n=102 observers). The evaluation sessions were similar for all groups, lasted 75 min, and were organized as follows: introduction, test A, short training session, break, and test B. In total, video recordings of 22 cows were displayed twice in a random order (11 cows in each test × 2 replicates). Data were analyzed applying kappa coefficient, logistic regression, and testing for random effects of observers. The crude estimates of 95% confidence interval for weighted kappa in test A and B ranged, respectively, from 0.76 to 0.80 and 0.70 to 0.75. When adjusting for the fixed effects of video sample and gait scoring preferences, the probability of assigning the same mobility score twice to the same cow varied from 55% (sensory assessors) to 72% (fourth-year veterinary students). The random effect of the individual observers was negligible. That is, in general observers could categorize the mobility characteristics of cows quite well. Observers who preferred to assess the attributes back arch or the overall mobility score (based on uneven gait) had the highest agreement, respectively, 69 or 68%. The training session seemed insufficient to improve agreement. Nonetheless, even novice observers were able to achieve perfect agreement up to 60% of the 22 scorings with merely the experience obtained during the study (introduction and training session). The relatively small differences between groups, together with a high agreement, demonstrate that the new system is easy to follow compared with previously described scoring systems. The mobility score achieves sufficiently high within-observer repeatability to allow between-observer agreement estimates, which are reliable compared with other more-complex scoring systems. Consequently, the new scoring scale seems feasible for on-farm applications as a tool to monitor mobility within and between cows, for communication between farmers and veterinarians with diverse educational background, and for lamenessbenchmarking of herds.


Background: Pharmacological studies have shown that increasing the activity of Na+/H+ exchanger isoform 1 (NHE1) plays a critical role in the development of cardiac hypertrophy. Despite the importance of NHE1, direct inhibition of NHE1 has demonstrated several adverse side effects. It is has been demonstrated that p90 ribosomal S6 kinase (RSK) regulates the activity of NHE1. RSK, a downstream regulator of the mitogen activated pathway, has also been implicated in cardiac hypertrophy both in in vitro and in vivo models. The interplay between NHE1 and RSK in NHE1 induced cardiomyocyte hypertrophy remains unknown.

Methods and results: H9c2 cardiomyoblasts were infected with active NHE1 adenovirus in the absence and presence of dominant negative (DN) (N-terminal kinase dead protein) RSK adenovirus. H9c2 cardiomyoblasts expressing active NHE1 demonstrated a significant increase in cardiomyocyte hypertrophic parameters including cell area (NHE1 = 170.8±7.38%; P=0.05), protein content (NHE1 = 210±34.47%; P=0.05), NHE1 activity (NHE1=885.5±156.96%; P=0.05) and ANP mRNA expression (NHE1= 176.6 ± 19.39%; P=0.05). These parameters were significantly reduced upon concomitant administration of the DN RSK adenovirus. The NHE1 induced cardiomyocyte hypertrophy was associated with a significant increase in ROS production(NHE1: 127.16±1.2%; P=0.05), phosphorylation and activation of GATA4 (NHE1: 266.56±26.69%; P=0.05), which was significantly reduced upon adding DN RSK to NHE1 infected cells.

Stimulation with phenylephrine (PE) induced a marked increase in phosphorylation and activation of RSK and GATA4, which were reduced upon treatment with NHE1 inhibitor (EMD). Treatment with a RSK inhibitor (BID 1870) caused a marked decrease of GATA4 phosphorylation without affecting ERK phosphorylation following stimulation with PE.

Conclusion: Taken together, our study demonstrates that active NHE1 induces cardiomyocyte hypertrophy.Indirect inhibition of NHE1 by targeting RSK may regress the hypertrophic effect, thus making RSK a potential therapeutic target for alleviating cardiomyocyte hypertrophy.


Purpose
New product development (NPD) is a noteworthy field that has attracted the attention of scholars for its relevance for firm success. Based on bibliometric indicators and spatial distance network analysis, the authors outline the general structure overview of NPD research through the last 40 years of scientific production; identify and categorize key articles, authors, journals, institutions, and countries related to NPD research; identify and map the research subareas that have mostly contributed to the construction of NPD intellectual structure. The paper aims to discuss these issues.

Design/methodology/approach
The work uses the Web of Science Core Collection and the visualization of similarities viewer software. The analysis searches for all the documents connected to NPD available in the database. The graphical visualization maps the bibliographic data in terms of bibliographic coupling and co-citation.

Findings
The general NPD citation pattern evidences a construction of knowledge and learning, as evidenced in different subjects, such as biology or physics. Relevant contributions and contributors are highlighted as journals, articles, researchers, countries and institutions in overall NPD research and in its constituent subfields. Five subareas related to the NPD field based on journals and authors network are identified: marketing; operations and production; strategy; industrial engineering and operations; and management.

Originality/value
This paper contributes to the NPD literature by offering a global perspective on the field by using bibliometric data graphical networks, providing insights about the influence of individual actors and its contributions to build bridges between the different subfields of research in NPD.


Four samples collected from the Irosin ignimbrite and co-ignimbrite ash fall deposit in southern Luzon, Philippines, were subjected to Thermoluminescence ( TL ) age-dating to further refine the timing of the ignimbrite eruption. IrTL-01 and -02 are the matrix part of the ignimbrite, IrTL-03 is a 10 cm-diameter lithic fragment from the ignimbrite, and IrTL-04 is co-ignimbrite ash-fall deposit collected at the summit crater of the Inascan cone, 80 km north of the eruption source. The ages obtained are 36 ± 8 ka for IrTL-01, 38 ± 10 ka for IrTL-02, 33 ± 8 ka for IrTL-03 and 45 ± 10 ka for IrTL-04. TL ages of IrTL-01 and -02 are in good agreement with a previously reported AMS 14 C age of ca. 41 cal kBP. On the other hand, TL ages for IrTL-03 and -04 are not consistent with the 14 C age. IrTL-03 ( lithic fragment ) exhibits a TL signal that is very clear and provides good data, however the fading TL signal may possibly account for the younger than expected TL age. The grain size and water content of IrTL-04 ( ash-fall ) may possibly account for an older than expected TL age. Further experiments are needed for more precise TL ages for IrTL-03 and -04.


This thesis describes investigations into the [2+2] photocycloaddition reaction of vinylogous amides and imides contained within five membered rings with alkenes; the aim of this being the synthesis of aminocyclobutanes. The initial focus is towards intramolecular reactions, synthesising vinylogous amides with a tethered alkene. Irradiation of these compounds leads to a [2+2] photocycloaddition followed by a spontaneous retro-Mannich fragmentation, affording keto-imines. Upon addition of a Boc group to these vinylogous amides, and irradiation of the resultant vinylogous imides, the retro-Mannich fragmentation is prevented and aminocyclobutanes are isolable. Attention is then turned to the intermolecular [2+2] photocycloaddition reaction which does not occur at all with vinylogous amides. However, upon adding an acetyl or Boc group to the vinylogous amides, the intermolecular reaction does take place with certain alkenes. This reaction affords aminocyclobutanes, often as a mixture of regio- and diastereo-isomers. Removal of the Boc group again leads to the retro-Mannich fragmentation taking place. The resultant imine is hydrolysed under the reaction conditions, and 1,5-diketones are obtained in an analogous manner to the de Mayo reaction. If the alkene used in the irradiation has a leaving group connected to the double bond, then this is eliminated after the retro-Mannich fragmentation. In this case, the products are novel conjugated enaminones. The chemistry of these compounds is then investigated. They undergo a Diels-Alder reaction with maleimide and are transformed into aminotropones upon heating or via a bromination-elimination reaction.


Higher-order proximity (HOP) is fundamental for most network embedding methods due to its significant effects on the quality of node embedding and performance on downstream network analysis tasks. Most existing HOP definitions are based on either homophily to place close and highly interconnected nodes tightly in embedding space or heterophily to place distant but structurally similar nodes together after embedding. In real-world networks, both can co-exist, and thus considering only one could limit the prediction performance and interpretability. However, there is no general and universal solution that takes both into consideration. In this paper, we propose such a simple yet powerful framework called homophily and heterophliy preserving network transformation (H2NT) to capture HOP that flexibly unifies homophily and heterophily. Specifically, H2NT utilises motif representations to transform a network into a new network with a hybrid assumption via micro-level and macro-level walk paths. H2NT can be used as an enhancer to be integrated with any existing network embedding methods without requiring any changes to latter methods. Because H2NT can sparsify networks with motif structures, it can also improve the computational efficiency of existing network embedding methods when integrated. We conduct experiments on node classification, structural role classification and motif prediction to show the superior prediction performance and computational efficiency over state-of-the-art methods. In particular, DeepWalk-based H2 NT achieves 24% improvement in terms of precision on motif prediction, while reducing 46% computational time compared to the original DeepWalk.


New techniques for more accurate and efficient simulation of ion implantations by a stepwise numerical integration of the Boltzmann transport equation (BTE) have been developed in this work. Instead of using uniform energy grid, a non-uniform grid is employed to construct the momentum distribution matrix. A more accurate simulation result is obtained for heavy ions implanted into silicon. In the same time, rather than utilizing the conventional Lindhard, Nielsen and Schoitt (LNS) approximation, an exact evaluation of the integrals involving the nuclear differential scattering cross-section (dσn=2πpdp) is proposed. The impact parameter p as a function of ion energy E and scattering angle φ is obtained by solving the magic formula iteratively and an interpolation techniques is devised during the simulation process. The simulation time using exact evaluation is about 3.5 times faster than that using the Littmark and Ziegler (LZ) spline fitted cross-section function for phosphorus implantation into silicon.


Ukraine's financial results over the past few months prove that the economic crisis which has
been ongoing since mid 2012 has exacerbated. According to data from the Ukrainian Ministry
of Economy, Gross Domestic Product for the first six months of 2014 shrank by 3%. In the second
quarter, it fell by 4.6%1 and may further be reduced by as much as 8–10% over the year
as a whole. After the first six months of this year, the balance of payments deficit reached
US$4.3 billion. After deflation last year, prices grew by 12%, and the hryvnia dropped to
a historic low. Although a surplus was seen in Ukrainian foreign trade in goods and services,
reaching over US$3 billion at the end of June, its trade volume is shrinking. The main reason
behind this deteriorating situation is the actions taken by Russia. Moscow has been fomenting
the conflict in Donbas since April, has consistently imposed embargoes on imports of more and
more Ukrainian goods and cut gas supplies to Ukraine in June. This has forced the government
to focus on the current management of state finances and to carry out budget sequestration
twice this year. The government has also used this as an excuse not to implement necessary systemic
reforms. The increasing share of military expenditure, the shrinking exports (-5% in the
first six months), including in particular to Russia, which until recently was Ukraine's key trade
partner, and the rapid fall in industrial production and investments have all made the situation
even worse. All that saves Ukraine from an economic collapse is the loan from the International
Monetary Fund and higher taxes, which allows the government to maintain budget liquidity.
However, if the conflict in Donbas lasts longer and if Russia continues its economic blackmail,
including withholding gas supplies, the economic crisis may prove to be long-lasting.


The late time physics of interacting QFTs at finite temperature is
controlled by hydrodynamics. For CFTs this implies that heavy operators
– which are generically expected to create thermal states – can be
studied semiclassically. We show that hydrodynamics universally fixes
the OPE coefficients C_{HH'L}CHH′L,
on average, of all neutral light operators with two non-identical heavy
ones, as a function of the scaling dimension and spin of the operators.
These methods can be straightforwardly extended to CFTs with global
symmetries, and generalize recent EFT results on large charge operators
away from the case of minimal dimension at fixed charge. We also revisit
certain aspects of late time thermal correlators in QFT and other
diffusive systems.


Mint (Mentha genus) is an herbaceous herb that is fragrant useful for centuries with spices and medicinal herbs. Study on optimum nutrient solution sufficient to meet the plants' demands regarding soilless culture of mint would be helpful for its application in plant factory, but was less reported. In the current study, 0.5 fold (×), 0.75×, 1.0× and 1.25× concentrations of Yamazaki formula nutrient solution were applied to culture the mint seedlings using river sand as the substrate. The results showed that 0.75× concentration of nutrient solution was optimum for mint seedlings across 15 to 36 days treatments, which dramatically promoted the growth rates, enhanced the content of chlorophyll, and improved yield as well as quality, followed by other desirable concentrations, ranking as 0.5×> 1.0×> 1.25× times, on growth of mint were distinct. Therefore, we concluded that the optimum concentration for mint seedling growth was 0.75× concentration, and highlighted the importance of using Yamazaki formula nutrient solution for mint seedlings growth, which potentially guides soilless cultivation of mint.

 Key words: Mint, Japanese raw materials, nutrition, hydroponics.


Abstract We investigated the spatial and temporal dispersion patterns of entomopathogenic nematodes (Steinernematidae and Heterorhabditidae) and their host insects in a citrus orchard located in the semiarid region of Israel (the Negev). Spatial patterns of entomopathogenic nematodes were studied in plots differing on their shade level, and at two geographic scales: a macro-scale, which included the entire orchard, and a micro-scale, which investigated the spatial patterns around individual trees. Spatial patterns of insect hosts were only studied at the macro-scale. At the macro-scale, soil samples were obtained from a symmetrical grid in which samples were separated by a distance of ≈20 m; and in the micro-grid, soil samples were separated by a distance of 50 cm. Population levels of entomopathogenic nematodes were spatially autocorrelated using Moran's I statistics. Population loads of entomopathogenic nematodes, and their spatial and temporal patterns, were not affected by the orchard's shade level. Entomopathogenic nematode loads were higher during the fall, which coincides with the reported abundance of their main hosts in this region, grubs of Maladera matrida (Argaman). At the investigated scales and distances, we were unable to detect any spatial dependence of entomopathogenic nematode populations or of insect hosts. However, clusters of entomopathogenic nematodes were found to be highly localized in small volumes of soil. At the level of the entire plot area we found a very strong correlation between the number of host insects at a particular time and the level of entomopathogenic nematodes (as indicated by a laboratory bioassay) 1 mo after (shifted-back correlation). We conclude that entomopathogenic nematodes in the Negev orchards have a very low probability of encountering insect hosts, and that under the environmental conditions of the Negev, effective biological control with entomopathogenic nematodes can only be achieved by inundative releases.


The research is purpose to find out implementation spatial planning policies on Bekasi city for stainable environmental management? Analytical methods used are: 1) Geo-physics analysis of land suitability analysis, 2) physical analysis; 3) Analysis of environmental management, 4) Analysis of socio-economic conditions, and 5) Analysis Geographic Information System (GIS). The results obtained that spatial planning and environmental carrying capacity can be concluded that to meet the needs of diverse development needs to develop a spatial pattern of land use, coordinate, procedures for water and other resources in a unified a dynamic environment. To meet the needs of diverse development needs to develop a spatial pattern coordinate system guana land, procedures for water and other resources in a unified order dynamic environment. For that layout needs to be managed by an integrated pattern through a regional approach with respect to site natural environment, socio-cultural environment, and the artificial environment in accordance with its development. Good city spatial structure with more increased public participation in city layout is expected to be better. The parties involved in these activities the city department of administration, the whole society. There is a direct influence on the city hall community participation in maintaining a healthy environment, so if you want to increase public participation in maintaining a healthy environment can be done by increasing the city spatial planning. Knowledge to community environmental management in maintaining a healthy environment, can be done by improving environmental management Knowledge community. The implementation of spatial management that take by the government in accordance with the spatial planning and its implementation has been set well and need to optimize. In the spatial implementation among others include: planning the provision and utilization of green open space, and plan the provision and utilization of network infrastructure and pedestrian facilities. Keywords: Analisys of Wisdom, lay out, participation society


Modelling of spatially homogeneous and piecewise-homogeneous image textures by novel Markov and non-Markov Gibbs random fields with multiple pairwise pixel interactions is briefly overviewed. These models allow for learning both the structure and strengths (Gibbs potentials) of the interactions from a given training sample. The learning is based on first analytic and then stochastic approximation of the maximum likelihood estimates (MLE) of the potentials. A novel learning approach, giving explicit, to scaling factors, estimates of the potentials, is outlined. It exploits the conditional MLE provided that the training sample may rank a feasible top place within the parent population in its total Gibbs energy. The models embed both simulation and segmentation of the grayscale piecewise-homogeneous textures into the same Bayesian framework exploiting a controllable simulated annealing to generate the desired texture or its region map. Experimental results in simulating and segmenting various natural textures are presented and discussed. Key-words: Texture simulation, segmentation, Gibbs field, parameter estimation


Modern scholarship has accepted the 'backgrowth of isnāds' in the early hadīth tradition, but this phenomenon did not occur without controversy among classical Muslim scholars. Hadīth critics were aware that material was being pushed back to the Prophet, a phenomenon they approached through the lens of ziyāda (addition). By examining works devoted to criticizing hadīth narrations ('ilal) from the 3rd/9th to the 8th/14th centuries, we will see that the original non-Prophetic versions of many hadīths survived alongside their Prophetic counterparts well into the 5th/11th century. More importantly, certain hadīth scholars from the 3rd/9th to the 7th/13th centuries believed that Prophetic reports in the canonical hadīth collections were actually statements of other early Muslims. The position of these critics, however, was marginalized in the 5th/11th century, when mainstream Sunni jurists chose to accept the Prophetic versions categorically. Although the jurists' position became dominant in Sunni Islam, criticism of the backgrowth of isnāds has continued in the work of select hadīth scholars until today.


States increasingly are shifting Medicaid beneficiaries with disabilities from the fee-for-service (FFS) delivery system to managed care in an effort to control program costs and address long-standing problems with access to care under the program. Using a county-based measure of managed care enrollment and pooled data from the 1997 to 2004 National Health Interview Surveys, we investigate whether Medicaid managed care (MMC), relative to FFS Medicaid, improves access to care. We find some evidence of improved access to care under MMC; however, the gains appear to be largely limited to beneficiaries in urban areas with fully capitated managed care. There is little evidence of improved access under primary care case management or, regardless of MMC type, in rural areas.


In mice, integrin alpha 4 beta 7 is the main receptor used by lymphocytes that home to the Peyer's patches, although L-selectin contributes to the initial interaction with high endothelial venules. Less is known about the expression and function of these adhesion molecules in humans. The distribution of L-selectin and alpha 4 beta 7 on various B- and T-cell subsets was examined in human Peyer's patches (n = 8) and appendix (n = 4), collectively called gut-associated lymphoid tissue. Multicolor immunophenotyping was performed on cryosections, and dispersed cells were examined by flow cytometry. In cryosections, CD45RA+ T cells around and within interfollicular high endothelial venules, as well as surface (s)IgD+ B lymphocytes in the follicle mantles, often expressed abundant L-selectin but only intermediate levels of alpha 4 beta 7. CD45RO+ T cells and sIgD- B cells expressed higher levels of alpha 4 beta 7 and were often located near putative efferent lymphatics; only a small fraction (< 20%) of such memory cells expressed L-selectin. By flow cytometry, considerably more T than B lymphocytes co-expressed L-selectin and alpha 4 beta 7 (40% versus 25% and 67% versus 39%, respectively). In samples with many L-selectin+ cells (> 30%), more of these lymphocytes co-expressed alpha 4 beta 7 than in samples with few L-selectin+ cells. Because L-selectin and alpha 4 beta 7 were co-expressed on lymphocytes located near high endothelial venules, and because such co-expression was relatively common when many L-selectin+ cells were present, both of these molecules might participate in homing to human gut-associated lymphoid tissue. Such homing is probably most pronounced for T lymphocytes that were found to express L-selectin and alpha 4 beta 7 more often than B lymphocytes. The selective and relatively high expression of alpha 4 beta 7 on memory cells located near efferent lymphatics indicated a different migratory capacity; after exit from gut-associated lymphoid tissue, such stimulated cells might home mainly to mucosal effector sites.


Parallel processing is an attractive option for relational database systems. As in any parallel environment however, load balancing is a critical issue which affects overall performance. Load balancing for one common database operation in particular, the join of two relations, can be severely hampered for conventional parallel algorithms, due to a natural phenomenon known as data skew. In a pair of recent papers (J. Wolf et al., 1993; 1993), we described two new join algorithms designed to address the data skew problem. We propose significant improvements to both algorithms, increasing their effectiveness while simultaneously decreasing their execution times. The paper then focuses on the comparative performance of the improved algorithms and their more conventional counterparts. The new algorithms outperform their more conventional counterparts in the presence of just about any skew at all, dramatically so in cases of high skew. >


Tumors have long been viewed as a population in which all cells have the equal propensity to form new tumors, the so called conventional stochastic model. The cutting-edge theory on tumor origin and progression, tends to consider cancer as a stem cell disease. Stem cells are actively involved in the onset and maintenance of colon cancer. This review is intended to examine the state of the art on colon cancer stem cells (CSCs), with regard to the recent achievements of basic research and to the corresponding translational consequences. Specific prominence is given to the hypothesized origin of CSCs and to the methods for their identification. The growing understanding of CSC biology is driving the optimization of novel anti-cancer targeted drugs.


This paper describes a novel approach for class-dependent modeling and its application to automatic text-independent speaker verification. This approach maximizes the conditional mutual information between the model scores and the class identity given some constraints on the scores. It is shown in the paper that maximizing the differential entropy of the scores generated by the classifier or the detector is an equivalent criterion. This approach allows emphasizing different features, in the feature vector used in the detection, for different target speakers. In this paper, we apply this approach to the NIST 2003 1-speaker verification task. Compared to the baseline system, around 10% relative improvement in the minimum detection cost function (DCF) is obtained.


Background—The cross-sectional association between impaired glucose/diabetes and depression is inconsistent. We examined the longitudinal associations between diabetes, indicators of glucose metabolism and depressive symptoms over 2 years follow up. Methods—Participants were 4338 men and women from the English Longitudinal Study of Ageing, a prospective study of community dwelling older adults (aged 62.9 ± 9.0 yrs, 45.2% men). Depressive symptoms were assessed at baseline and 2 years follow up using the 8 item CES-D scale. Haemoglobin A1C levels, fasting glucose and other biological and behavioural risk factors were also assessed at baseline. Results—Approximately 11.5% of the sample were categorised with elevated depressive symptoms at follow up (a score ≥ 4 on the CES-D). There was an association between A1C and depressive symptoms at follow up (per unit increase, odds ratio [OR]= 1.17, 95% CI, 1.03 – 1.33) after adjustment for age and baseline CES-D. Cross-sectionally, the probability of depressive symptoms increased with increasing HbA1c levels until the value of 8.0% after which there was a plateau (p[curve]=0.03). Compared to those with normal fasting glucose, participants with diabetes (confirmed through self report or elevated fasting blood glucose) at baseline had elevated risk of depressive symptoms at follow up (OR=1.52, 95% CI, 1.01 – 2.30) after adjusting for depressive symptoms at baseline, behavioural and socio-demographic variables, adiposity and inflammation. Conclusions—These data suggest that poor glucose metabolism and diabetes are risk factors for future depression in older adults. There was no evidence of a U-shaped association.


A plane sound wave is incident upon one of two infinite parallel plates that are constrained along a line by a mechanical connector, which is simply hinged to both plates and which can support compressional motion. A formal solution is obtained and investigated for the cases where the plate upon which the sound wave is incident is subjected to heavy fluid loading while the parallel plate is subjected to light fluid loading and the fluid between the plates is either light or heavy. When the plates are separated by heavy fluid the additional limits of large and small plate spacing are used.


A number of biological rhythms originate from networks comprised of multiple cellular oscillators. But analytical results are still lacking on the collective oscillation period of inter-coupled gene regulatory oscillators, which, as has been reported, may be different from that of an autonomous oscillator. Based on cyclic feedback oscillators, we analyze the collective oscillation pattern of coupled cellular oscillators. First we give a condition under which the oscillator network exhibits oscillatory and synchronized behavior. Then we estimate the collective oscillation period based on a novel multivariable harmonic balance technique. Analytical results are derived in terms of biochemical parameters, thus giving insight into the basic mechanism of biological oscillation and providing guidance in synthetic biology design.


Abstract
Increasing operational costs and narrowing profit margins are forcing many Hong Kong travel agencies out of business. Studies have demonstrated the strategic importance of revenue management (RM) implementation for travel agencies that wish to remain competitive. Hong Kong travel agencies should learn from these examples and modify their existing practices. As travel agencies have many of the characteristics of traditional and non-traditional RM industries, they should be able to adopt the RM operational strategies that have been successful in other industries. This study's methodology is qualitative; in-depth interviews are conducted with 10 industrial professionals. The results provide valuable insights into RM implementation in Hong Kong travel agencies. The implementation strategies discussed here include the use of perishable inventories, predictable demand, segmentation, reservations made in advance, limited capacity and appropriate cost and pricing structures, all of which aid in profit optimisation. The results indicate that RM can improve travel agencies' competitive stance and enhance profit maximisation. RM practitioners need to fully understand the concept and techniques and have the determination to develop and promote the system among personnel at every level of the travel agency.


Abstract Aim: To evaluate risk factors for pulmonary hemorrhage (PH) in extremely low birth weight infants (ELBW) taking into consideration coagulation screens, platelet counts, transfusion of fresh frozen plasma (FFP), and platelet concentrates prior to PH. Patients and methods: A retrospective case-control study consisting of 20 ELBW infants with PH and 40 matched controls. Coagulation screens, platelet counts at birth and at onset of PH, and transfusion frequencies prior to PH were compared to case-controls at birth and 24–96 h after birth. Results: While the initial platelet counts, fibrinogen concentrations, and international normalized ratios were similar in PH infants and controls, the activated partial prothrombin time was prolonged (P=0.05). Compared to 28% of case controls (P<0.05), 55% of infants with later PH received FFP prior to PH. Platelet counts were significantly lower at onset of PH (median 81/nL; range: 37–236/nL) compared to controls (166/nL; 27–460/nL; P<0.005). Multivariate analysis indicated a lack of antenatal steroids, supplemental oxygen, and transfusion of FFP as independent risk factors for PH. Conclusion: Prolonged activated partial thromboplastin time (aPTT) might be associated with PH. PH does not primarily depend upon severe thrombocytopenia. A developmental mismatch in hemostasis by transfusion of adult donor plasma should be considered a risk factor for PH.


The LSH-study started in 2003 at the department of Health and Society at the University of Linkoping. The purpose of the study was to examine the relationship between life condition, stress and health. A total of 1007 people from ten different health centres in Ostergotlands lan participated. At the follow up, a couple of years later, 795 of the 1007 participated. 127 of the 212 in the attrition turned down the follow up, twelve people were not invited (for example in case of death) and the rest did not respond at all. The purpose of this paper is to find out in what degree the attrition in the follow up can be predicted using the information from the first survey and which variables are important. The differences between different types of attrition have also been examined. Simple and multiple bi- and multinomial logistic regression have been used in the analysis.In total 34 variables were examined and in the final model six variables remained with a significant relation to the attrition. High BMI, regular smoking, high pulse and lack of daily exercise at the first survey were connected to a higher risk for an individual to not participate at the follow up. It is interesting that these factors are considered as risk factors for unhealthy living. Other factors related to a higher attrition were unemployment in the last year before the first survey and if the individual had parents born in another country than Sweden. The risk for attrition increased gradually when more risk factors were shown by the individual. The factors contributing an individual to turn down the follow up instead of not responding at all was if he or she were in the older age segments in the survey or if they were not active in any type of association.


Empty electron states in Fe-based systems have been studied by Inverse Photoemission spectroscopy excited by low energy polarized electrons. Along with bulk-like transitions, surface (or interface) features are clearly identified. Ultrathin epitaxial films, namely Fe/Au(100) and Ag/Fe(100), and the clean Fe(100) surface are considered as examples. In thin films, majority and minority quantum well states originated by the electron confinement within the overlayer are observed. For ferromagnetic films in the monolayer regime, data indicate an exchange splitting exceeding the bulk value. At the Fe(100)-vacuum interface image-potential derived surface states display an unexpected reversal of the ordering of the majority and minority levels. Spin resolution allows to unambiguously identify the spin character of the states.


Abstract This paper examines the relationship between the shadow economy and trade openness in Uganda, using autoregressive distributed lag bounds testing approach. We find that the shadow economy and trade openness have a long- and short-run relationship. These results hold even when alternative econometric methods are used. The empirical evidence indicates that more exposure to foreign trade significantly reduces the size of the shadow economy. This could imply that as countries become more integrated into the world economy, firms and individual entrepreneurs are induced to engage in the formal sector so as to reap the benefits of international markets. This paper shows that trade openness is an important determinant of the shadow economy in both the short- and long-run. At the policy level, any policy framework that strengthens integration into the global economy will be an effective tool that can reduce shadow activities in both the short- and long-run. The practical implication of these results is that countries that have fully reformed their economies to allow for free trade and investment inflows experience a decline in shadow activities implying that, in more open economies, more trade reduces informality.


Lixivaptan is a non-peptide, orally-active vasopressin antagonist under development by American Home Products for the potential treatment of hyponatremia associated with diseases such as heart failure, liver cirrhosis and nephrotic syndrome. By 1997, it was in phase II trials in the US and elsewhere for hyponatremia [2424051. It selectively prevents vasopressin-dependent water resorption, increasing water excretion with low electrolyte loss [266993] and is selective towards the human V2 versus V1 receptors [295987].


. The oleander aphid, Aphis nerii Boyer de Fonscolombe, feeds on milkweeds in the Apocynaceae family. Characteristics including trichome density and leaf toughness vary among milkweed species. The hypothesis that host plant characteristics influence the frequency of defensive behaviors exhibited by this aphid against the parasitoid, Lysiphlebus testaceipes (Cresson), was tested in a laboratory experiment. Interactions between oleander aphids and L. testaceipes were investigated on four milkweed species with different physical characteristics. Aphids responded to parasitoid presence with spinning, kicking, bucking, a coordinated defense, and the excretion of cornicle wax. When excreted, cornicle wax reduced parasitoid foraging time regardless of host plant species. The most common response to parasitoid presence was a coordinated defense behavior on all host plant species. When spinning, kicking, bucking, and coordinated defenses were combined per host plant species, aphid defenses tended to be greater in frequency on Cynanchum laeve and Asclepias incarnata than on A. tuberosa with A. syriaca being intermediate. Our results suggest that aphids colonizing host plants with few physical defenses may exhibit a greater number of defensive behaviors than aphids on plants having rougher leaf textures and high trichome densities.


We describe techniques to characterize the light curves of regular variable stars by applying principal component analysis (PCA) to a training set of high-quality data, and to fit the resulting light-curve templates to sparse and noisy photometry to obtain parameters such as periods, mean magnitudes etc. The PCA approach allows us to efficiently represent the multiband light-curve shapes (LCSs) of each variable, and hence quantitatively describe the average behaviour of the sample as a smoothly varying function of period, and also the range of variation around this average.

In this paper we focus particularly on the utility of such methods for analysing Hubble Space Telescope (HST) Cepheid photometry, and present simulations which illustrate the advantages of our PCA template-fitting approach. These are: accurate parameter determination, including LCS information; simultaneous fitting to multiple passbands; quantitative error analysis; objective rejection of variables with non-Cepheid-like light curves or those with potential period aliases.

We also use PCA to confirm that Cepheid LCSs are systematically different (at the same period) between the Milky Way and the Large and Small Magellanic Clouds, and consider whether LCS might therefore be used to estimate the mean metallicities of Cepheid samples, thus allowing metallicity corrections to be applied to derived distance estimates.


In plasma membranes of human neutrophils, we identified two major pertussis toxin substrates of 40 kDa Mr with pI values of 5.30 and 5.37. Only the acidic of the two substrates was also present in neutrophil cytosol. Two-dimensional tryptic peptide maps revealed a high degree of homology of cytosolic and particulate substrates. Purified G-protein beta gamma-complex stimulated pertussis toxin-catalyzed [32P]ADP-ribosylation of membranous and cytosolic substrates of neutrophils less than 2-fold and 6-fold, respectively. Hydrodynamic properties of the cytosolic substrate strongly suggested that it exists as a monomer. Purified G-protein beta gamma-complex increased the s20,w value of the cytosolic substrate from 3.3 S to 4.0 S. The GTP analogue, guanosine 5'-O-(3-thiotriphosphate), promoted the release of pertussis toxin substrates from plasma membranes. An antiserum raised against a sequence specific for the Gi2 alpha-subunit reacted with 39-40 kDa proteins in plasma membranes and with an apparently single 40 kDa protein in cytosol. We conclude that neutrophil cytosol contains monomeric Gi2 alpha-subunits which--by interacting with hydrophobic beta gamma-complexes--may reversibly bind to the plasma membrane.


OJK has issued regulation No.51/POJK.03/2017 on The Application of Sustainable Finance for Financial Services Institution, Issuer and Public Companies, requires all financial services institutions, including banks to applied sustainable financial principles. While some of the principles of sustainable finance are already part of banking regulation such the obligation to implement risk management and governance, they have not specifically accommodated the demand to integrate economic, social and environmental aspect as a pillar of sustainable banking. This study is used normative juridical approaches and analytical descriptive research specifications, legal issues are how to implement sustainable financial principles in the banking sector and urgency of the bank's sustainable report as an effort to identify bank compliance with sustainable financial principles. Banks are required to make and publish sustainable financial statements as a form of bank accountability to all stakeholders to comply with governance principles, in particular transparency obligations.  This sustainable reporting is a form of report conducted by a company in order to disclose or communicate to all stakeholders on good environmental, social and governance performance in an accountable manner.


Abstract:This article examines the "misalignments" between "manaw maheikdi dat pangyi" (the painting or art of the fundamental elements of the phenomenal world by way of intense mental concentration) by Bagyi Aung Soe, Myanmar's forerunner of modern art, and a narrative of modern art modelled after western modernism. Three tropes are proposed: "modern", "Burmese" and "Buddhist" art. It asks: how did Aung Soe negotiate his alma mater Śāntiniketan's lessons with the paradigm of modern western art in Myanmar? It next explores the embarrassments of the nation-centric construct of "Burmese art". Lastly, how might "manaw maheikdi dat pangyi" serve to rethink art historical approaches to the study of Buddhist art and homologous art forms that similarly elude the modern construct of "art"?


Introduction: The methodological work of the department of morfofisiologia loans special attention to the quality of the educational process. One of the purposes is the suitable employment of the valued criterion of the professor like a focus of the efficiency of the process, that it is useful to his time also for the prediction of the educational results, in the individual and collective. Objective: The present work studies the correlation of the valued criterion of the professor with the achievement of the aims of the subjects, expressed this last by the educational results obtained in the ordinary examination. It was studied its chronological behavior in the period of five years Material and Methods: A matrix of correlation was created. We determined the coefficient of Spearman. Some factors that could influence in its objectivity predict were also identified by the study. Results: The review of the registers of methodological meetings, open classes and newspapers of classes allowed us to identify some factors that could act on the valued criterion of the professor. They can improve the objectivity of the correlation between this criterion and the academic achieving at the final examination in the subject of molecular biology in the students of first year on medicine career. Conclusions: To attention and systematic monitory of the individual educational evolution and collective in the methodological work of the subject and in the department, attains to increase the efficiency of the valued criterion of the professor and its correlation with the ends academic results. The results constitute an educational innovation for the methodological work in the subjects that integrate the Biological Bases of the Medicine.


In the UK, patients normally see their general practitioner first and 86% of the health needs of the population are managed in general practice, with 14% being referred to specialist/hospital care. Early diagnosis is the privilege of general practice since general practitioners make most medical diagnoses in the NHS. Their historic aim has been to diagnose as early as possible and if possible before patients are aware of symptoms. Over time, diagnoses are being made earlier in the trajectory of chronic diseases and pre-symptomatic diagnoses through tests like cervical screening. Earlier diagnosis benefits patients and allows earlier treatment. In diabetes, the presence of lower HbA1c levels correlates with fewer complications. Methodologically, single practice research means smaller populations but greater ability to track patients and ask clinicians about missing data. All diagnoses of type 2 diabetes, wherever made, were tracked until death or transfer out. Clinical opportunistic screening has been undervalued and is more cost-effective than population screening. It works best in generalist practice. Over 19 consecutive years, all 429 patients with type 2 diabetes in one NHS general practice were analysed. The prevalence of type 2 diabetes rose from 1.1% to 3.0% of the registered population. Since 2000, 95.9% were diagnosed within the general practice and the majority (70/121 = 57.9%) of diagnoses were made before the patients reported any diabetes-related symptom. These patients had median HbA1c levels 1.1% lower than patients diagnosed after reporting symptoms, a clinically and statistically significant difference (P = 0.01).


Wireless video sensor networks has been examined and evaluated for wide range of applications comprising of video surveillance, video tracking, computer vision, remote live video and control. The reason behind importance of sensor nodes is its ease of implementation, ability to operate in adverse environments, easy to troubleshoot, repair and the high performance level. The biggest challenges with the architectural design of wireless video sensor networks are power consumption, node failure, throughput, durability and scalability. The whole project here is to create a gateway node to integrate between "Internet of things" framework and wireless sensor network. Our Flexi-Wireless Video Sensor Node Platform (WVSNP) is a low cost, low power and compatible with traditional sensor network where the main focus was on maximizing throughput or minimizing node deployment. My task here in this project was to address the challenges of video power consumption for wireless video sensor nodes. While addressing the challenges, I performed analysis of predicting the nodes durability when it is battery operated and to choose appropriate design parameters. I created a small optimized image to boot up Wandboard DUAL/QUAD board, capture videos in small/big chunks from the board. The power analysis was performed for only capturing scenarios, playback of reference videos and, live capturing and realtime playing of videos on WVSNP player. Each sensor node in sensor network are battery operated and runs without human intervention. Thus to predict nodes durability, for different video size and format, I have collected power consumption results and based on this I have provided some recommendation of HW/SW architecture.


Recently, industry has begun investigating and moving towards utility computing, where computational resources (processing, memory and I/O) are availably on demand at a market cost. On-demand access to computational resources enables fine-grained resource allocation for web-based applications, e.g., the possibility of provisioning for a minimum workload while allowing the rental of additional resources for unexpected workload changes. However, renting additional resources relies on the ability to quickly and accurately estimate the value of the resource. This paper introduces CARVE: a cognitive agent for resource value estimation. CARVE is a machine-learning based approach that learns to predict the change in system value of having more or less system resources. Using only low-level statistics and with no custom instrumentation of the operating system or middleware, CARVE is able to make informed decisions about the return on investment of physical memory when implemented and evaluated on a partitioned system running a multi-partition, multi-process distributed benchmark. We show that CARVE is competitive with static choices of computing resources over a variety of test workloads and also has the ability to outperform all static configurations.


Endophytes are defined as microorganisms that spend part of lifetime interior of plant tissues without causing negative effects. They have been used for agricultural purpose, biofuel production, bioremediation, medication, etc. In particular, endophytes have been emerged as a good source for bioactive secondary metabolites. A large number of secondary metabolites are currently being reported. In this report, we focus on the secondary metabolites that were originated from endophytic fungi inhabiting medicinal plants. They were classified into several groups such as nitrogenous compounds, steroids, sulfide-containing metabolites, terpenoids, polyketides, and miscellaneous for discussion of chemical structures and biological activities.


This paper describes how PMCD with an overbalanced drilling mud, instead of Light Annular Mud, was used to successfully drill and complete a well in gas bearing carbonates offshore Malaysia. This unconventional approach was adopted after encountering poor formation injectivity and severe dynamic losses in the 8-1/2″ reservoir section.
 Dynamic losses of 700 bbl/hr were encountered after drilling into the carbonate formation, but the subsequent injectivity test surface pressure prevented the well being converted to PMCD with LAM. LCM pills were spotted and the mud weight was cut by 0.2 ppg but severe dynamic losses continued. An injectivity test was performed with seawater and the surface pressure stabilized around 500 psi. Drilling resumed with overbalanced drilling mud in the annulus, which was top filled during connections to keep the hole full and to monitor the annulus with a nominal surface pressure, while seawater was pumped down the string.
 After reaching TD, the drilling BHA was retrieved to surface and the 7″ lower completion was run in hole while the well continued to take around 50 bbl/hr static losses. When the lower completion entered the open hole, PMCD was activated to run in and set the liner hanger.
 This method of unconventional PMCD may be implemented to successfully drill through carbonates with poor injectivity and severe dynamic losses, thereby improving the safety and efficiency of the drilling operations compared to conventional or floating mud cap drilling.


Considerable attention has been given in the last few years to the carbon spectrum in the extreme ultra-violet, that from an arc being investigated with a fluorite spectrograph by Wolff and McLennan, Ainslie and Fuller, and with a grating spectrograph by McLennan and Lang and McLennan and Petrie, while Millikan has measured the hot-spark spectrum to 360 A. U. On the whole, the agreement of these various workers as to the wavelengths of the lines is not very good, although McLennan and Petrie are in substantial agreement with Millikan concerning the most intense lines. It was thought worth while therefore to take an opportunity which offered to make another independent measurement of the wave-lengths of a number of lines in the arc spectrum, with the result that some have been photographed in the Lyman region which have been mentioned by no previous worker with the arc, and by the study of some of the lines in higher orders of spectrum, they have been shown in many cases to consist of close groups of lines. 2. Description of Apparatus. The vacuum grating spectrograph used is shown in outline in fig. 1. It consisted of a metal tube with chamber at the side for the introduction of a drying agent. The grating was mounted in a carriage provided with means for giving the grating a limited rotation about each of three mutually perpendicular axes. The carriage could be moved along slides, fixed near to one end of the tube, by a screw, so as to allow of accurately focussing the spectrum upon the photographic plate. This end of the spectrograph was closed by a metal plate. To the other end of the tube was soldered a casting carrying photographic plate and two slits. The position of the plate was fixed, the plate-holder being cylindrical and having the surface against which the plate was held worked to the same radius of curvature as that of the grating. The slits were placed immediately beneath the dark slide and recessed so that each lay on the same focal surface as the grating and photographic plate. Their distance apart was such that a range of spectrum of about 800 A. U. was obtained from either slit, these ranges overlapping by rather more than 80 A. U. for the same setting of the grating, and the focus of the spectrum being equally sharp whichever slit was employed. A shutter, operated by a permanent magnet mounted externally in a rotating collar, enabled two exposures to be made on the photographic plate which measured 6 cm. x 1 cm.


INTRODUCTION
Microcytic anemias are very common in clinical practice, with iron deficiency anemia (IDA) and thalassemia minor (TT) being the most prevalent. Diagnostic confirmation of these clinical entities requires tests involving iron metabolism profile, hemoglobin electrophoresis, and molecular analysis. In this context, several discriminant indices have been proposed to simplify the differential diagnosis between IDA and TM.

OBJECTIVE
The aim of this paper was to demonstrate the clinical relevance of the use of discriminant indices in individuals with microcytic anemia to simplify the differential diagnosis between iron deficiency anemia and minor thalassemia.

METHODS
A bibliographic and cross-sectional search was performed in the PubMed, SciELO and LILACS databases, using the following descriptors: iron deficiency anemia, thalassemia minor, and differential diagnosis.

RESULTS
More than 40 mathematical indices based on erythrocyte parameters have been proposed in the hematological literature in individuals with microcytosis. Green & King indexes (IGK), Ehsani index, and erythrocyte count (RBC) had excellent performances, especially when their efficacy was observed in adults and children.

CONCLUSIONS
Confirmatory tests for differential diagnosis between IDA and TM require time-consuming and costly methods. Despite the excellent performances of IGK, Ehsani index, and RBC, none of them presented sufficient sensitivity and specificity to establish a diagnosis. However, they can provide a powerful additional tool for diagnostic simplification between IDA and TM.


Between 1941 and 1944, the Spanish Division of Volunteers took part in the Russian campaign as a unit integrated in the German Wehrmacht. Post-1945 war memoirs and even some historians have suggested that the 'Blue' Division was exceptional for their benign treatment of civilians and prisoners, distanced from the German War of Extermination. This image has not been subjected to critical enquiry. To what degree were the Spanish troops different from other Wehrmacht troops? Was the collective behaviour of the Spanish soldiers determined by the circumstances they encountered at the front, or was it related to their prior political socialization?


ABSTRACT Group work has been increasingly encouraged and applied in Vietnamese universities. However, very little has been known about how Vietnamese university students work in a group and what the conditions are that help establish an effective group. This study attempted to redress this gap. The research applied Bourdieu's social field theory to examine experiences of Vietnamese students in groups. It specifically explored Vietnamese students' perceptions of interactions with 'cultural and linguistic others' and how their interactions were constrained and enabled by personal and contextual factors. Employing a qualitative research methodology, the study revealed that student interactions were strongly influenced by the rules set-up in the field, possessing capital resources valued in the field and disposition towards working with other cultures.


In this paper I present Mobile Stories, a design-led project that explored ways of playfully motivating and engaging theatre audiences in their journey before the premiere of a theatrical play. The project used the art of storytelling and mobile technology to engage the audience in a creative way. The ultimate goal was to investigate innovative ways of connecting theatres with their audiences in meaningful organic relationships that can be sustained. I discuss the design mechanisms that were developed to enable participation, describe issues and opportunities with the specific approach and discuss the value of the project for the audience, the theatre, and the research on designing for audience engagement.


The paper presents the results of the investigation concerning time and space organization of brain cortex electric activity and peculiarities of autonomic regulation of cardiac functions in 19 healthy individuals, which had a pronounced intention to counteract of hypnotic influence. Taking into consideration the reactions to hypnosis, these individuals were divided into three groups: predisposed to hypnotic suggestion, sensitive (intermediate group) and resistant to hypnotic suggestion. In predisposed individuals there were more pronounced sympathetic influences on cardiac functions and less spectral power of all EEG rhythms, except beta 2-rhythm. In individuals resistant to hypnotic suggestion there was more pronounced alpha-rhythm in brain cortex, while sympathetic influences on the cardiac functions were not so pronounced. All individuals reacted to hypnotic suggestion by a decreasing of the representation of alpha-rhythm and by diminishing initial interhemispheric asymmetry. However, a share of beta-rhythm was increased in predisposed individuals and of theta-rhythm in resistant individuals. In posthypnotic state in resistant persons the correlations of initial EEG rhythms were completely recovered, while in the individuals from the other groups a recovery was observed only in separate EEG frequencies.


A plasma fluid code B2 has been benchmarked with a one-dimensional plasma fluid model incorporating the anisotropic ion pressures (AIP model) on simple mirror configurations. In a low collisionality case, profiles of plasma parameters of the B2 code deviate from those of the AIP model. The validity of the viscous-flux approximation is investigated by direct comparisons with the anisotropic part of the ion pressure indicating the invalidity of the viscous-flux approximation is considered to be responsible to deviations of profiles. In addition, supersonic plasma flows downstream from the mirror throat are observed.


Correlation between the BOD/COD ratio and Partition coefficient of octanol/ water (Pow) on a single organic substance shows that the Pow value is directly proportional to the toxicity level and inversely proportional to BOD/COD ratio. This research examined the correlation to a mixture of organic substances. The objective is to obtain a varied range of substances, as well as determining the quality of wastewater discharging to fresh waters. Need for analysis of organic substances used as antiseptics during the Covid-19 pandemic. In addition, organic substances from the organophosphate pesticide class, diazinon, were used. BOD5, COD, Pow, and LC50-96h toxicity tests using Daphnia magna were used. Six types of the mixture of organic substances included diazinon-formaldehyde-isopropyl alcohol, ethanol-oxalic acid-formaldehyde, isopropyl alcohol-glycerol-lactose, acetic acid-isopropyl alcohol-formaldehyde, sucrose-glycerol-acetic acid, and oxalic acid-formaldehyde-diazinon, with 3 different concentrations of 10, 100, and 1000 mg/L, three repetitions. The lowest BOD/COD ratio (<0.2) and the highest Pow value (>4) are found in diazinon-formaldehyde-IPA. Its toxicity in D. magna also showed the lowest LC-50 (11.82 mg/L). Whereas, sucrose-glycerol-acetic acid had the highest BOD/COD ratio (>0.7) and lowest Pow (<0.7) with the highest LC- 50 (567.88 mg/L). Other organic substances mixtures have characteristics in the range of these mixtures. Pow variability and the BOD/COD ratio have a negative correlation. A mixture of organic matter is more biodegradable making it has a higher tendency to dissolve in water.


OBJECTIVES
It was intended to compare various characteristics of phonation obtained in cases who underwent near-total laryngectomy (NTL) and frontolateral laryngectomy (FLL).

STUDY DESIGN
The study included 29 male cases, 9 of whom underwent NTL, 10 of whom underwent FLL and 10 who had normal laryngeal speech. All cases were evaluated and compared statistically according to the fundamental frequency (Fo), intensity and voiceless time measurements, maximal phonation time (MPT), speech rate and speech intelligibility.

RESULTS
Fo and Fo range were found significantly high in both patient groups, but MPT and speech rate was meaningfully decreased in these groups relative to the control group. There were not any significant differences between the two patient groups. The speech intelligibilities of the NTL group patients were significantly low relative to other two groups. The voiceless time measurements during phonation were significantly high in two patients groups, but we also found that it was not effective on speech rate and intelligibility.

CONCLUSION
The phonation gained after NTL is similar to that of FLL in respect of various features. But owing to differences of the speech intelligibility measurements, we concluded that patients who underwent NTL could be exposed to more problems during communication with their social surroundings.


Given an interconnection of a nominal discretetime plant and a stabilizing controller together with structured, norm bounded, nonlinear/timevarying perturbations, necessary and sufficient conditions for robust stability and performa.nce of the system are provided. This is done by first showing that performance robustness is equivalent to stability robustness in the sense that both problems can be dealt with in the framework of a general stability robustness problem. The resulting stability robustness problem is nest shown to be equivalent to a simple algebraic one, the solution of which provides the desired necessary and sufficient conditions for performance/stabili ty robustness. These conditions provide an effective tool for robustness analysis and can be applied to a large class of problems. In particular, it is shown that some known results can be obtained immediately as special cases of these conditions.


We report on the first X-ray images of the Phoenix dwarf galaxy, taken with XMM–Newton in 2009 July. This Local Group dwarf galaxy shares similarities with the Small Magellanic Cloud (SMC) including a burst of star formation ∼50 Myr ago. The SMC has an abundance of high-mass X-ray binaries (HMXBs) and so we have investigated the possibility of an HMXB population in Phoenix with the intention of furthering the understanding of the HMXB–star formation rate relation. The data from the combined European Photon Imaging Cameras (EPIC) were used to distinguish between different source classes [foreground stars, background galaxies, active galactic nuclei (AGN) and supernova remnants] using EPIC hardness ratios and correlations with optical and radio catalogues. Of the 81 X-ray sources in the field of view, six are foreground stars, four are galaxies and one is an AGN. The remaining sources with optical counterparts have log(fX/fopt) consistent with AGN in the local Universe. Further investigation of five sources in the field of view suggests that they are all background AGN. Their position behind the gas cloud associated with Phoenix makes them a possible tool for further probing the metallicity of this region. We find no evidence for any HMXBs in Phoenix at this time. This rules out the existence of the X-ray persistent supergiant X-ray binary systems. However, the transient nature of the Be/X-ray binaries means we cannot rule out a population of these sources but can conclude that it is not extensive.


893 Individual variation in drug metabolism is a major cause of treatment failures during cancer therapy. Because variations can lead to unpredictable and erratic drug side effects, there is a considerable need to modulate the pharmacodynamics of therapeutics to maximize efficacy and minimize side effects. Individual variations stem from differences in activity and abundance of drug metabolizing enzymes, including the cytochrome p450 family, whose expression is regulated at the level of transcription by orphan nuclear receptors. We have found that ketoconazole, a known inhibitor of p450 enzyme activity, represses the transcription of genes central to drug metabolism and transport by blocking the activation of nuclear receptors. Ketoconazole prevented the activation of endogenous as well as transiently transfected genes in cell lines and primary human and mouse hepatocytes. This inhibition was mediated by blocking the activation of nuclear receptors hPXR and CAR but not other nuclear receptors such as ERα or PPARγ. Ketoconazole disrupted the interaction between hPXR and co-activators in both mammalian two-hybrid assays and in co-activator dependent receptor ligand binding assays (CARLA). Furthermore, ketoconazole specifically inhibited PXR mediated gene transcription of cyp3a11, mdr1 and mrp2 in mice. Using LORR (Loss of Righting Reflex), we found that treatment of mice with ketoconazole inhibited the metabolism, and hence the functional consequences, of a CYP450 substrate-tribromoethanolamine. Finally, in wild type mice (n=6), we demonstrate that the pharmacokinetics of paclitaxel are normalized. Short term treatment with ketoconazole markedly reduces variation in treated population, and this effect coincides with decreased transcription of cyp3a11 and mrp2 in liver and mdr-1 in small bowel. These studies demonstrate for the first time that ketoconazole can inhibit the transcriptional activation of drug metabolism genes in vivo. Thus, ketoconazole has the potential to be used clinically to reduce individual variability in therapeutic responses.


A new and simple HPTLC method was developed and validated for the simultaneous quantitative determination of Wedelolactone and Phyllanthin in hepatoprotective Hepasuport tablet. TLC aluminium plates precoated with silica gel 60F-254 (0.2 mm thickness) were used. The samples were dissolve in methanol and linear ascending development was carried out in twin trough glass chamber saturated with mobile phase Toluene: Ethyl acetate: Formic acid (5.0:4.0:1.0, v/v/v) and densitometric determination of these compounds was carried out by TLC scanner (CAMAG) at 254 nm in reflectance/absorbance mode. The Rf value of wedelolactone and phyllanthin was found to be 0.56 ± 0.02 and 0.65 ± 0.03 respectively. The method was validated with respect to specificity, linearity, accuracy, precision, ruggedness and robustness as per the International Conference on Harmonization (ICH) guidelines. Results found to be linear in the concentration range of 600ng to 1600 ng with r2 = 0.998 and 0.995 for wedelolactone and phyllanthin, respectively. The percent recoveries were found to be 100.06 and 99.35 for wedelolactone and phyllanthin respectively. The method can be used for routine analysis of these phytoconstituents in tablet dosage forms in quality control laboratories.


This paper explores a bottom-up way to speculate towards future smart cities by inviting residents of Copenhagen, Denmark to participate in sensing activities. It illustrates how the idea of "design things" could support bottom-up citizen participation in a smart city. It uses a research through design approach, deploying a wearable air quality sensor to three Copenhageners. By investigating citizens' perception of the city through this prototype, we illustrate a possible path for engagement in the development of future smart city technologies that offer a greater sense of influence and relevance for residents. Further, citizen participation in sensing activities provides a route to different understandings of smart cities: as a place for people and participation instead of for data and rationalisation.


ABSTRACT Teaching is a highly complex profession, one in which teachers have to make continuous pedagogical decisions. In this study, we argue that practical wisdom is needed in order to act thoughtfully and effectively. The prerequisite for using practical wisdom is teachers' awareness of the pedagogical beliefs behind the decision-making. In this study, this has been described as personal practical theories: PPTs. In other words, practical wisdom is possible if PPTs are consistent with pedagogical decision-making and furthermore teaching practice. The aim of this study is to seek the ways teacher education may support the cultivation of practical wisdom in student teachers. For that purpose, we carried out a qualitative descriptive study by interviewing 15 primary school student teachers about their experiences with PPTs, and their manifestation in their practicum studies. Further, what factors support the manifestation, or create obstacles to them. Based on the results, in this study, we suggest ways in which practical wisdom could be promoted in initial teacher education.


ABSTRACT Previous research has demonstrated the transformation of metallic lead into pyromorphite in solid and liquid medium by several species of fungi. In this work, the soil fungus Paecilomyces javanicus was found to mediate formation of an unknown lead mineral phase after incubation in liquid media with lead shot. After 2 weeks' incubation, precipitated mineral phase particles were collected and X-ray powder diffraction (XRPD) revealed the presence of plumbonacrite (Pb10(CO3)6O(OH)6). After 4 weeks' incubation, the lead particles that accumulated inside the fungal pellets were transformed into a white lead-containing secondary mineral phase. Energy dispersive X-ray analysis (EDXA) and XRPD were used to attempt to identify the lead-containing secondary minerals produced. XRPD showed that lead oxalate (PbC2O4) and cerussite (PbCO3) were present as lead mineral species. However, another mineral phase was present that was not identifiable by XRPD. Fourier transform infrared spectroscopy (FTIR) identified hydroxyl (−OH) and carbonate (−CO32−) groups as the main functional groups within this unidentified secondary mineral phase. It was therefore concluded that this mineral phase is a new species of lead hydroxycarbonate. This is the first discovery of fungal-mediated formation of plumbonacrite and a new lead hydroxycarbonate, and therefore reveals a novel step in lead carbonation by fungi.


Purpose. To report the radiological and clinical results of revision total hip arthroplasty (THA) with femoral impaction bone grafting (IBG). Methods. 4 men and 9 women (15 hips) aged 38 to 84 years underwent revision THA with femoral IBG using Elite plus stems for aseptic loosening or infection. Results. The mean follow-up duration was 7.7 years. The Harris hip score improved from 61.7 to 83.7. There was no pain in 11 hips and slight pain in 4. The mean subsidence was 5.7 mm. The mean change of alignment was 1.2°. There was no radiological evidence of stem loosening. One stem was revised due to a peri-prosthetic fracture. Cortical healing was noted in 11 hips, and trabecular incorporation in 10. Conclusion. Although intra- and post-operative complications were not uncommon, femoral IBG is a safe procedure in carefully selected patients and offers good medium-term results.


Today phase change memory (PCM) technology has reached product maturity at 90 and 65 nm nodes, while the 45 nm node is under development and is expected to enter in the market soon. The continuous decrease of the cell size with scaling leads to an effective active area as small as 150 nm2 and an active volume involved in the phase transformation of about 104 nm3, thus entering definitively into the nanotechnology world. At this extremely reduced dimension, the reliability of the device must be carefully investigated. In this work we show that the cycling performance of the device is well maintained, not being a problem for either the bipolar transistor or the storage element. The phase transition from the amorphous to the crystalline state is, of course, one of the most interesting phenomena, impacting cell retention capability and device performance. The stochastic nature of nano-nuclei percolation in the amorphous matrix is shown as an important ingredient in the retention of PCM devices. The related dispersion in crystallization times is analyzed through a crystallization Monte Carlo model and a physical insight into nucleation and growth mechanisms is provided.


Optical spectropolarimetry of the luminous IRAS source FSC 10214+4724 (z=2.286) reveals that the strong (approximately 17%) linear polarization detected by Lawrence et al. is shared by both the narrow ultraviolet (UV) emission lines and the underlying continuum. This observation and the brightness of the source rule out synchrotron emission and dichroic extinction by dust as the polarizing mechanism, leaving scattering as the only plausible cause of the polarized emission. The narrowness of the lines requires that the scatterers be dust grains or cool (below 1.6 x 10(exp 4) K) electrons. We can recover the spectrum that is incident on the scattering medium provided we make some reasonable assumptions regarding the source geometry. The scattered UV spectrum has a power-law index alpha of -1.2 plus or minus 0.6 (F(sub nu) varies as nu(sup alpha)), steeper than would be expected from a young burst of star formation but similar to that of many active galactic nucleus (AGNs).


Despite the increased risk of domestic violence among women living with HIV/AIDS, its burden has not been adequately explored in many developing countries including Nigeria. Using interviewer administered questionnaires we assessed the prevalence and risk factors for domestic violence among 300 HIV seropositive women attending a teaching hospital in northern Nigeria. Participants have been diagnosed HIV positive for an average of 6.7 years; 66.3% were seroconcordant with their intimate partners while 16.3% were serodiscordant, the rest 17.4% did not know the partner's status; 67.1% had disclosed their status to their partners; and 64(22.1%) [95% CI (17.5% to 27.4%)] had experienced domestic violence following HIV diagnosis. Specifically, 30.0% (n = 19) experienced physical violence (slapping, kicking and punching), 59.3% (n = 38) reported verbal violence (insults, threats) and 10.7% (n = 7) endured emotional violence. None was sexually assaulted. Predictors of domestic violence were the woman's age, marital status, disclosure and partner's educational status. This calls for urgent steps and strategies for prevention, protection and post-test counseling on disclosure to avert this human right infringement.


Applying modular logic to service design is crucial to service innovation; however, both under-modularity and over-modularity results in strategic mistakes, in particular to the IT service offering companies. This paper firstly identifies four dimensions of the conceptual modular IT service platform for designing and providing service to the customers. And a mathematical model is developed and applied to evaluate the degree of modularity for the designed unique services.


Four Irish setters were diagnosed with bilateral retinal degeneration and cataracts at an age ranging from six to 11 years. In three of these dogs, progressive night blindness was reported from an age of eight to 11 years. In the fourth dog, aged six, no signs of visual impairment had been noticed. In all four dogs, the rod-cone dysplasia type 1 (rcd1) mutation was excluded as a cause, using an allele-specific PCR. From their three-generation pedigrees, a familial relationship was detected in three out of four dogs, which were also related to four additional Irish setter dogs with a history and clinical signs suggestive of late-onset progressive retinal degeneration. These results suggest the existence of a possibly hereditary, late-onset, progressive retinal atrophy in the Irish setter breed, that is distinct from rcd1.