N6-methyladenosine (m6A) is the most prevalent modification to RNA in higher eukaryotes. ALKBH5 is an RNA demethylase that impacts RNA export and metabolism, and its aberrant expression is associated with the generation of tumours. In this study, we found that ALKBH5 was highly expressed in both primary CD138+ plasma cells isolated from multiple myeloma (MM) patients and MM cell lines. Downregulation of ALKBH5 inhibited myeloma cell proliferation, neovascularization, invasion and migration ability, and promoted the apoptosis in vivo and in vitro. MeRIP-seq identified the SAV1 gene as main target gene of ALKBH5. Inhibiting ALKBH5 in MM cells increased SAV1 m6A levels, decreased SAV1 mRNA stability and expression, suppressed the stem cell related HIPPO-pathway signalling and ultimately activates the downstream effector YAP, exerting an anti-myeloma effect. Additionally, MM stem cell phenotype was suppressed in ALKBH5-deficient cells and the expression of pluripotency factors NANOG, SOX2 and OCT4 were also decreased. Altogether, our results suggest that ALKBH5 acts as an oncogene in MM and might serve as an attractive potential biomarker and therapeutic target.


Recently, Lucia et al. have used a distillation line method to develop the concept of shortest stripping line distance approach to minimum energy designs of distillation columns and multiunit processes. It is well known that distillation line methods can be very sensitive to specified product compositions. A two-level distillation design procedure is proposed for finding portfolios of minimum energy designs when specifications are given in terms of key component recoveries. Thus, product compositions are not specified but calculated. It is shown that the proposed two-level design procedure is flexible and can find minimum energy designs for both zeotropic and azeotropic distillations. It is also shown that the two-level design method encompasses Underwood's solution but can find minimum energy designs when Underwood's method fails. Numerical results for several distillation examples involving ternary and quaternary mixtures are presented to support these claims, and geometric illustrations are used to elucidate key points. © 2008 American Institute of Chemical Engineers AIChE J, 2008


The role of Micro, Small and Medium Enterprises or Small and Medium Enterprises (SMEs) in a country's economic growth is considered important. SMEs have a large and crucial contribution to the Indonesian economy. MSMEs have an important role in development and economic growth. The role of SME is not only felt in developing countries but also in developed countries. In developed and developing countries, MSME is very important, because it absorbs the most labor compared to large businesses. The contribution of MSMEs to the formation or growth of Gross Domestic Product (GDP) is greater than the contribution of large businesses. However, in reality the amount is inversely proportional to quality. Many MSME actors whose HR quality is still low, both in education and technology. The low quality of human resources has an impact on their productivity. This study aims to find out how the Development Strategy of Micro Small and Medium Enterprises in the Manufacturing Industry Sector in Bekasi District. The use of the Location Quotient (LQ) method is used to find out what business bases can be used by MSMEs based on LQ analysis calculations. The use of TOWS analysts deepens the discussion of what and how MSME strategies compete. From the LQ analysis calculation results it appears that Bekasi Regency, the processed industry business sector, is a leading sector with an LQ index number > 1. As we know, Bekasi Regency's economic strength is indeed sourced from the industrial sector. Furthermore, the SME development strategy is based on the TOWS analysis, with the characters in each of the different MSMEs. The strategies used include: SO (Strength Opportunities), ST (Strength Threat) strategy, WO (Weakness Opportunites) strategy and WT (Weakness Threat) strategy.


Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA

A major contributor to carcinogenesis is the molecular chaperone heat shock protein 90 (Hsp90). Hsp90 regulates the proper folding and stabilization of several client proteins, including human epidermal growth factor receptor 2 (ErbB2) and hypoxia-inducible factor 1α (HIF-1α). ErbB2 is a member of the epidermal growth factor receptor (EGFR) family of receptor-proteins, and is a clinical target for the treatment of metastatic cancer, while HIF-1α is often stabilized and overexpressed in several cancers. The ability for Hsp90 to become a mature complex and to properly fold client proteins is dependent on adenosine triphosphate (ATP) binding with the co-chaperone, p23. Specific Hsp90 inhibitors, like geldanamycin, target the Hsp90 ATP-binding site to prevent formation of the mature complex. Although supplementation with docosahexaenoic acid (DHA; C22:6 n-3) has not been shown to specifically target the Hsp90 ATP-binding site, the current study demonstrates a similar effect by DHA causing a reduction in available intracellular ATP levels. DHA is the longest, most unsaturated omega-3 polyunsaturated fatty acid (PUFA) existing in biological membranes and has been shown to possess anti-cancer activity in several cancer models. Studies from our laboratory have shown that DHA enrichment can reduce cancer cell metabolism and intracellular ATP levels in both breast and lung cancer models. In this study, a novel mechanism for the ability of DHA to inhibit the Hsp90 chaperone complex is defined. In vitro analyses of BT-474 human breast ductal carcinoma, as well as the A549 human lung adenocarcinoma cell lines were used to determine the impact of DHA-induced decreases of intracellular ATP levels. We found that the reduction in ATP levels by DHA treatment resulted in significant decreases in the association of Hsp90 and p23 in both cell lines. The decreased association of the Hsp90-p23 complex led to decreased levels of ErbB2 and HIF-1α client proteins, suggesting that DHA can modify Hsp90 chaperone function and attenuate client protein levels. Additionally, similar results were found when employing 2-deoxyglucose (2-DG), a glycolytic inhibitor, which confirms that DHA and 2-DG can disrupt Hsp90 molecular chaperone function by decreasing cellular ATP levels. Consistent with these observations, when using a dose of DHA that did not significantly reduce intracellular ATP levels, no change in the Hsp90-p23 chaperone complex or protein levels of ErbB2 and HIF-1α were seen. These results demonstrate a potential use for dietary intervention to improve cancer therapy in tumors that overexpress Hsp90 client proteins.

Citation Format: Michael Mouradian, Irvin V. Ma, Erika D. Vicente, Keith D. Kikawa, Amy M. Chattin, Ronald S. Pardini. Docosahexaenoic acid inhibits heat shock protein 90 complex and client proteins by reducing intracellular ATP levels in breast and lung cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 483. doi:10.1158/1538-7445.AM2014-483


Summary and Conclusions
A rectal scraper is described which was found to be a satisfactory instrument for the collection of specimens of mucus and fecal material from the rectal wall and for their transportation from the field to the laboratory. The direct examination of material collected with a single-grooved scraper was found to be less efficient than the routine acid-Triton NE-ether method of stool concentration for the detection of Schistosoma mansoni eggs, although the scraper method detected a significant number of positives missed by the concentration technique. Further investigation of the scraper method is indicated. In its present state, the scraper technique may prove to be a useful complement to stool concentration methods in the diagnosis of S. mansoni infections and should be of value in situations where the collection of fecal specimens is impractical or facilities for stool concentration are lacking.


Many U.S. transit agencies have been using planning support software to assist in daily planning, operation, and customer services. However, the literature is not clear about the extent to which transit agencies are using planning support software programs for daily activities. To determine the state of the practice in the use of planning support software in the U.S. transit agencies, a survey was conducted. The survey found that the use of planning support software confirms the general trend in the use of information technology: that is, its use is directly related to the size of the transit agencies. Larger transit agencies tend to use more planning support software, while small agencies do not use that much. Probably one of the most important findings is that many smaller transit agencies consider the purchase and use of planning support software in transit planning, operation, and marketing as unnecessary, especially given the difficulties in obtaining funding, training staff, and hiring and retaining technical support personnel. However, those difficulties are mainly caused by constraints in budgeting and technical staffing issues rather than the undesirability of or the unproved or unrealized benefits related to the use of planning support.


Alzheimer's disease (AD) is the leading type of dementia worldwide. Despite an increasing burden of disease due to a rapidly aging population, there is still a lack of complete understanding of the precise pathological mechanisms which drive its progression. Glutamate is the main excitatory neurotransmitter in the brain and plays an essential role in the normal function and excitability of neuronal networks. While previous studies have shown alterations in the function of the glutamatergic system in AD, the underlying etiology of beta amyloid (Aβ1–42) induced changes has not been explored. Here we have investigated the acute effects of stereotaxic hippocampal Aβ1–42 injection on specific glutamatergic receptors and transporters in the mouse hippocampus, using immunohistochemistry and confocal microscopy 3 days after Aβ1–42 injection in aged male C57BL/6 mice, before the onset of neuronal cell death. We show that acute injection of Aβ1–42 is sufficient to induce cognitive deficits 3 days post-injection. We also report no significant changes in glutamate receptor subunits GluA1, GluA2, VGluT1, and VGluT2 in response to acute injection of Aβ1–42 when compared with the ACSF-vehicle injected mice. However, we observed increased expression in the DG hilus and ventral stratum (str.) granulosum, CA3 str. radiatum and str. oriens, and CA1 str. radiatum of the GluN1 subunit, and increased expression within the CA3 str. radiatum and decreased expression within the DG str. granulosum of the GluN2A subunit in Aβ1–42 injected mice compared to NC, and a similar trend observed when compared to ACSF-injected mice. We also observed alterations in expression patterns of glutamatergic receptor subunits and transporters within specific layers of hippocampal subregions in response to a microinjection stimulus. These findings indicate that the pathological alterations in the glutamatergic system observed in AD are likely to be partially a result of both acute and chronic exposure to Aβ1–42 and implies a much more complex circuit mechanism associated with glutamatergic dysfunction than simply glutamate-mediated excitotoxic neuronal death.


Background: Female genital mutilation (FGM) is a global challenge with estimated over two hundred million girls and women worldwide having undergone the procedure and another three million girls are at risk of being cut yearly. The prevalence of FGM among women and girls aged 15-49 years in Somali region of Ethiopia is 99% compared to the national average of 65%. The study assessed the knowledge, attitude, and practice of health care workers on FGM practices in the region.Methods: The study was a cross-sectional descriptive survey and used quantitative method.Results: 36 (17.8%) of the health workers believed FGM was a mandatory religious practice, while 158 (78.2%) regarded it as a cultural practice. All the respondents knew it caused health problems, 32 (15.8%) believed it was a good practice though 176 (87.1%) of the respondents believed it violated human rights of the girls/women and 99 (49%) wanted the practice to continue. 15 (40.5%) had conducted FGM on a girl before, 5 (13.5%) claimed medicalization made FGM practice safer and 5 (13.5%) of the respondents intended to circumcise their daughters in future.Conclusions: Health care workers still have attitudes and practices that positively promote and could encourage FGM practices in spite of their knowledge of the health consequences and their acceptance as a violation of the rights of women and girls. This attitude has high tendencies of depriving the community members of access to accurate information that will enable them to make informed decision about FGM and efforts to eradicate the practice.


A multiplexed holographic video has been achieved with a passive liquid crystal cell, whose response time is in the order of several milliseconds. Meanwhile, reconstructed RGB images are merged as a white color image, providing a possibility of real‐time color holographic three‐dimensional display. In addition, the dependence of the intensities of reconstructed images on the polarization direction of reading beam is investigated.


The Federal Transit Administration (FTA) State Safety Oversight Rule (49 CFR Part 659) requires oversight for all rail transit agencies in revenue operation after January 1, 1997. This report summarizes activities performed to implement the State Safety Oversight Program during Calendar Year 1999. Information provided by State Oversight Agencies documenting the safety and security performance of the rail transit industry in 1999 is presented, including a discussion of the probable causes of accidents and unacceptable hazardous conditions. This report also highlights procedures and policies, developed by State Oversight Agencies and rail transit systems, which have been particularly effective in supporting the objectives of the State Safety Oversight Program.


Long non-coding RNAs (lncRNAs) are crucial players in the pathogenesis of non-small-cell lung cancer (NSCLC). A competing binding of lncRNAs and mRNAs with microRNAs (miRNAs) is one of the most common mechanisms of gene regulation by lncRNAs in NSCLC, which has been extensively researched in the last two decades. However, alternative mechanisms that do not depend on miRNAs have also been reported. Among them, the most intriguing mechanism is mediated by RNA-binding proteins (RBPs) such as IGF2BP1/2/3, YTHDF1, HuR, and FBL, which increase the stability of target mRNAs. IGF2BP2 and YTHDF1 may also be involved in m6A modification of lncRNAs or target mRNAs. Some lncRNAs, such as DLGAP1-AS2, MALAT1, MNX1-AS1, and SNHG12, are involved in several mechanisms depending on the target: lncRNA/miRNA/mRNA interactome and through RBP. The target protein sets selected here were then analyzed using the DAVID database to identify the pathways overrepresented by KEGG, Wikipathways, and the Reactome pathway. Using the STRING website, we assessed interactions between the target proteins and built networks. Our analysis revealed that the JAK-STAT and Hippo signaling pathways, cytokine pathways, the VEGFA-VEGFR2 pathway, mechanisms of cell cycle regulation, and neovascularization are the most relevant to the effect of lncRNA on NSCLC.


Significant amounts of phosphorus (P) accumulate in soils receiving animal manures that could eventually result in unacceptable concentrations of dissolved P loss through surface runoff or subsurface leaching. The degree of phosphorus saturation (DPS) relates a soil's extractable P to its P sorbing capacity, and is reportedly a predictor of the P likely to be mobilized from a system. A DPS value (DPS-1) was derived that expressed the percentage of Mehlich 1-extractable P to the sorbing capacity of a Spodosol (expressed as the sum of oxalate-extractable Fe and Al). Values of DPS-1 were determined in various horizons of soil in current and abandoned dairy systems in South Florida's Lake Okeechobee watershed to assess P release potential. Land use within the dairies was classified as highly impacted by cattle (intensive and holding), and minimally impacted by cattle (pasture, forage, or native) areas. The A and E horizon of soils in heavily manure-impacted intensive and holding areas for both active and abandoned dairies generally had higher DPS-1 values than the pasture, forage, and native area soils, which were minimally impacted by manure. Degree of P saturation was also calculated as a percentage of Mehlich 1-extractable P to the sum of Mehlich 1-extractable Fe and Al (DPS-2). Both DPS-1 and DPS-2 were shown to be significantly (P = 0.0001) related to water-extractable P for all soil horizons, suggesting that either index can be used as an indicator for P loss potential from a soil.


Ochratoxin A (OTA) is a toxic secondary metabolite produced mainly by Penicillium spp. and Aspergillus spp. and commonly found in foodstuffs and feedstuffs. Carboxypeptidase A (CPA) can hydrolyze OTA into the non-toxic product ochratoxin α, with great potential to realize industrialized production and detoxify OTA in contaminated foods and feeds. This study constructed a P. pastoris expression vector of mature CPA (M-CPA) without propeptide and signal peptide. The results showed that the degradation rate of OTA by M-CPA was up to 93.36%. Its optimum pH was 8, the optimum temperature was 40 °C, the value of Km was 0.126 mmol/L, and the maximum reaction rate was 0.0219 mol/min. Compared with commercial CPA (S-CPA), the recombinant M-CPA had an improve stability, for which its optimum temperature increased by 10 °C and stability at a wide range pH, especially at pH 3–4 and pH 11. M-CPA could effectively degrade OTA in red wine. M-CPA has the potential for industrial applications, such as can be used as a detoxification additive for foods and feeds.


A mechanism of the cosmological constant vanishing in gauged N = 4 supergravity on the background Mp = Tp × R4−p at finite temperature is analysed. Here Tp, R4−p are the p-dimensional torus and the flat space, respectively, p = 1, ..., 4. It is shown that this mechanism results from the one-loop Casimir effect. Some cosmological scenarios and the possibility of extending these results to gauged N = 8 supergravity are discussed.


Authors present the case (from the year 2003) of a 38 years old patient, female with large tumor in the abdominal cavity. Preoperative differential diagnostic examination showed either tumor of pancreas or left liver lobe. The surgery confirmed large tumor body of the pancreas. Histological and immunohistochemical examination determined gastrointestinal stromal tumor (GIST) of the pancreas from autonomous nerves with malignant character. Tumor was radically removed. In the postoperative period regular follow up was done at the department of oncology, abdominal ultrasound every 3 months, CT scan every 6 month. 2.5 years after operation the patient has no problems, CT scan is without signs of recurrent diseases. The analysis of GIST was performed in agreement with contemporary knowledge. According to the references, our case report GIST of pancreas is the first of this kind (till 2003).


Chemical processes that could occur in the anode chamber of an electrolytic cell divided by a semipermeable membrane when direct current passes through a water solution of weak mineralization are described. The interest concerns the possibility of a formation of chemical substances with strong oxidative action as O2 and H2O2, due to nascent oxygen. These substances can destroy the structure of pathogenic bacteria and viruses. The preservation of these properties for a long period of time without specific storage requirements makes the anolyte cheap and effective disinfection and therapeutic means.


In Wireless Sensor Networks (WSNs), symmetric key schemes may be used to provide security. Recently, a class of random key pre-distribution techniques have been proposed and investigated. Such techniques only guarantee to establish keys for some pairs of physically connected sensors. In this work, we address the issue of delivering secret link keys to each of the source's neighbors in wireless sensor networks. We propose a scheme called Babel that finds a common bridge node to deliver one key to each of the to-be-connected neighbors. The novelty of our scheme is to deliver multiple keys through a common bridge node and regular paths instead of multi-hop secure paths. Since the delivered keys are only disclosed to one node, the common bridge node, key compromise probability of the Babel scheme is significantly lower compared to other delivery techniques.


Despite vigorous studies on ultra high-strength concrete in Korea, it still faces many challenges in application to on-site construction methods. This study intends to evaluate the applicability of the VH separated-pouring method which is currently used and was designed to pour ultra high-strength concrete with a design strength of 60, 100N/㎟ separately to girder and beam. When it comes to VH separated-pouring, there is a difference in the required design strength between a girder and a beam, which tends to be larger for ultra high-strength concrete. The tensile strength and cold joint at the joint end have not been commonly evaluated and thus the inevitably of its use is dependent on a structural analysis of the structural stress of reinforcement. In the study, potential problems with respect to the building material which might occur during the pouring of ultra high-strength concrete was evaluated and issues on joint surface performance, the hydration energy contained in the members, and the effects of contraction in concrete were considered as the key elements for study.


In phase-change memory (PCM), low-field electrical resistance is typically used to quantify the programmed cell state. However, this metric has several disadvantages. First, it exhibits temporal drift, which is a significant challenge for realizing multilevel PCM. Moreover, because of cell-geometry effects, this metric saturates after a certain point and thus masks the fact that the amorphous size increases with increasing input power. Finally, the resistance is typically measured as the current for a fixed bias voltage, which adversely affects the signal-to-noise ratio at high resistance values. A new metric for the programmed state in a PCM cell is proposed that has significant advantages over the resistance metric in all these aspects and is more representative of the fundamental programmed entity, which is the amorphous/crystalline phase configuration in the PCM cell. Analytical and experimental results are presented that demonstrate the efficacy of the proposed metric.


E marketing is the concept which emerged in the last decade. People focused the internet only for the purpose of gathering information. But as the technology improves and the people started migration, they concentrated in e-marketing. E marketing can be defined in broader terms as not only trade in goods and services across internet but also new ways of conducting business and communicating with customers. E commerce is the technology of the present. It can provide services which is beneficial to both the rural community &corporate world. One of the best benefits of e commerce is that it can provide a cost effective way to expand into the global arena and run one's own business.


Detecting dental diseases through panoramic X-rays images is a standard procedure for dentists. Normally, a dentist need to identify diseases and find the infected teeth. While numerous machine learning models adopting this two-step procedure have been developed, there has not been an end-to-end model that can identify teeth and their associated diseases at the same time. To fill the gap, we develop YOLOrtho, a unified framework for teeth enumeration and dental disease detection. We develop our model on Dentex Challenge 2023 data, which consists of three distinct types of annotated data. The first part is labeled with quadrant, and the second part is labeled with quadrant and enumeration and the third part is labeled with quadrant, enumeration and disease. To further improve detection, we make use of Tufts Dental public dataset. To fully utilize the data and learn both teeth detection and disease identification simultaneously, we formulate diseases as attributes attached to their corresponding teeth. Due to the nature of position relation in teeth enumeration, We replace convolution layer with CoordConv in our model to provide more position information for the model. We also adjust the model architecture and insert one more upsampling layer in FPN in favor of large object detection. Finally, we propose a post-process strategy for teeth layout that corrects teeth enumeration based on linear sum assignment. Results from experiments show that our model exceeds large Diffusion-based model.


OBJECTIVE
MRI findings of ischiofemoral impingement (IFI) have been described, but there is little evidence for treatment with ultrasound-guided corticosteroid injection. The purpose of this study was to evaluate the effectiveness of ultrasound-guided corticosteroid injection of the quadratus femoris muscle as a treatment of IFI syndrome and to correlate the MRI findings with injection outcome.

MATERIALS AND METHODS
The medical records of 61 consecutively registered subjects who underwent bony pelvis MRI in which either IFI or quadratus femoris edema was described in the radiology report were retrospectively reviewed. Subjects with MRI findings of IFI and clinical confirmation of pain that could be attributed to IFI were included and divided into injection and control groups based on clinical management. Control subjects had MRI findings and clinical symptoms suggestive of IFI but underwent conservative therapy rather than injection. The control patients had adequate follow-up and clinical documentation to determine their response to treatment. Quadratus femoris muscle edema, fat atrophy, and hamstring tendinopathy were graded from none to severe (grades 0-3). The ischiofemoral and quadratus femoris spaces were also measured. Clinical presentation was classified as typical, somewhat typical, or not typical of IFI. Injection effectiveness was determined by reported pain reduction assessed before, immediately after, and 2 weeks after the procedure with a standard 10-cm visual analog scale. Response to treatment was classified as good (reduction in pain level > 2), mild or partial (reduced by 1 or 2), or no improvement. For patients who did not return their 2-week postinjection pain surveys, injection effectiveness was determined by qualitative assessments found in their clinical notes. A Kruskal-Wallis rank sum test was used to compare effectiveness of injection between groups (p < 0.05). The Fisher exact test was used to evaluate for associations between each MRI finding and injection outcome.

RESULTS
Of the 61 patients, 20 patients had both MRI findings and clinical confirmation of pain related to IFI. These 20 patients were included in the study. Fifteen ultrasound-guided injections were performed in seven patients, and these seven patients were included in the injection group (mean age, 47 years; range, 15-66 years); 13 patients were included in the control group (mean age, 42 years; range, 16-62 years). All seven patients in the injection group and 12 of the 13 patients in the control group were women. In the injection group, the mean width of the ischiofemoral space was 12 mm (range, 7-22 mm), and the mean width of the quadratus femoris space was 9 mm (range, 5-16 mm). The mean edema grade was 1.4 (range, 0-3); mean atrophy grade, 1.4 (range, 0-3); and mean hamstring tendinopathy grade, 1 (range, 0-2). In the control group, the mean width of the ischiofemoral space was 9 mm (range, 6-17 mm); mean quadratus femoris space width, 7 mm (range, 3-15 mm); mean edema grade, 1.9 (range, 1-3); mean atrophy grade, 1.2 (range, 0-3); and mean hamstring tendinopathy grade, 1.2 (range, 0-3). No statistical difference was seen between the two groups before treatment. Pain reduction after injection over the 2-week period was statistically significant with a mean reduction of 1.7 (range, 1-2) for the injection group and 0.8 (range, 0-2) for the control group (p < 0.01). Eleven of 15 (73%) of the injections provided good relief, and four of 15 (27%) provided mild relief. None of the 15 injections provided no relief. In the control group, four of 14 (29%) subjects had good relief, three of 14 (21%) had mild relief, and seven of 14 (50%) had no relief (p < 0.01).

CONCLUSION
Ultrasound-guided corticosteroid injection of the quadratus femoris muscle shows promise as an effective treatment of IFI syndrome. However, larger longitudinal studies are needed to help establish the role of ultrasound-guided injection in the workup and care of patients presenting with both MRI findings and clinical findings of IFI.


The dihydropyridine calcium channel blocker nifedipine did not affect spontaneous locomotor activity in mice when given alone but enhanced the depressant effects of the muscarinic receptor agonist oxotremorine and of the acetylcholinesterase inhibitor physostigmine. Such a behavioral depression might be due to neuronal changes induced by central calcium channel blockade combined with cholinergic activation. However, an involvement of hemodynamic factors, related to peripheral vasodilatation, cannot be excluded as locomotor depressant effects were also exerted by combinations of the two cholinomimetic agents with hydralazine, a non-calcium antagonist vasodilator.


There are only 5,000 patients in psychoanalysis with members of the American Psychoanalytic Association (APsaA), and these analysts are often viewed as arrogant and insular. As a laboratory for psychoanalytic institutions the APsaA provides crucial lessons for the future across the field. What ingredients are needed for psychoanalysis to be a vibrant discipline? What factors have prevailed where psychoanalysis is successful? The author explores the cases of Argentina and France, where psychoanalysis is relatively popular, and then returns to the U.S. situation. Insular mind-sets led to many missed opportunities for cultural and academic engagement in the United States. As an example, the author explores responses to the making of John Huston's film Freud: The Secret Passion. To become revitalized, psychoanalysis needs to be a cultural asset. Psychoanalysts need to build bridges, engage in partnerships, and emphasize the exciting method of philosophical probing of the human mind and the nature of human nature.


In recent years, new breakthroughs have been made in the field of shale oil and gas exploration in the Lower Jurassic Lianggaoshan Formation in Sichuan Basin. At present, there is a lack of systematic studies on reservoir properties and sedimentary facies of the Lianggaoshan Formation shale. Therefore, in this study, taking the Lianggaoshan Formation in Sichuan Basin as an example, the sedimentary facies types of shale reservoirs and their control over shale oil and gas are systematically studied, based on a large number of outcrops, experimental testing, logging, and seismic interpretation methods. The results show that five sedimentary microfacies are developed in the Lianggaoshan Formation in the study area, namely, semi-deep lake mud, shallow lake mud, wave-influenced shallow lake mud, delta-influenced shallow lake mud, and underwater interbranch bay microfacies. The stratum thickness of the Lianggaoshan Formation is in the range of 26–315 m, and mainly distributed in the eastern region, but rapidly thinned in the northwestern region. The sedimentary sequence framework of the Lianggaoshan Formation has been constructed. Moreover, the lithology of the Lianggaoshan Formation shale has been divided into three types, including shale, massive mudstone and silty mudstone. The brittleness index and total organic carbon (TOC) value of three types of shale show a negative correlation. Silty mudstone has the highest brittleness, while that of black shale is the lowest. For porosity and permeability, massive mudstone is better than silty mudstone, and silty mudstone is better than black shale. There are many kinds of matrix pores in the Lianggaoshan Formation shale, and the development degree of inorganic pores is higher than that of organic pores. Finally, based on the analysis of oil-bearing, pore types, physical properties and productivity, it is considered that black shale facies is the most favorable lithofacies type. The deep–semi-deep lacustrine facies belt obviously controls the shale oil enrichment of the Lianggaoshan Formation.


Purpose
This study aims to apply attribution theory to examine how internal stakeholders' attributions affect the perceived company's corporate social responsibility (CSR) initiatives on employees' pro-environmental behavioral intention through a mediated perceived CSR authenticity.

Design/methodology/approach
A questionnaire-based survey was used because of the standardized questions and ease of acquisition of the target data with the assistance of a Web-based tool.

Findings
The perceived company's other-centered CSR motives are positively associated with the perceived authenticity of the CSR engagement. The small company had a significantly stronger relationship than the large company. The perceived company's self-centered CSR motives are not associated with the perceived authenticity of the CSR engagement. The perceived authenticity of CSR engagement is positively related to its own pro-environmental behavioral intention.

Research limitations/implications
A larger sample size across different industries can improve the result. When the authors examine the effect of company size, multi-group sizes can be used instead of two groups. The above scenario usually works in normal businesses. How about the "dirty" business situation? Examples of dirty businesses are tobacco, gambling, alcohol and mining companies. During their business operations, they destroy our environment or create harmful effects on our health. Thus, dirty businesses engaging in CSR practices at the same time seems contradicting.

Practical implications
The management should ensure that employees perceive the company's CSR initiatives as other-centered rather than self-centered. Company size matters in terms of delivering other-centered CSR messages. Specifically, employees who work in a small company (i.e. less than 100 employees) are more favorable to other-centered CSR messages.

Originality/value
This study extends the CSR literature by examining how internal stakeholders' attributions (i.e. employees' attribution) of the perceived company's CSR initiatives influence employees' pro-environmental behavior through a mediated perceived CSR authenticity.


Abstract : The seasonal ocean circulation and thermal structure in the South China Sea (SCS) were studied numerically using the Princeton Ocean Model (POM) with 20 km horizontal resolution and 23 sigma levels conforming to a realistic bottom topography. A sixteen month control run was performed using climatological monthly mean wind stresses and restoring type salt and heat fluxes as surface forcing terms and observational oceanic inflow/outflow at the open boundaries. The seasonally averaged effects of isolated forcing terms are presented and analyzed from the following experiments: 1) non-linear effects removed, 2) wind effects removed, 3) open boundary inflow/outflow set to zero, and 4) open boundary inflow/outflow doubled. This procedure allowed analysis of spatial and temporal contributions of the isolated parameter to the general hydrology of the SCS and some of its specific features. A coastal jet is identified and analyzed, as are a mesoscale topographic gyre and several counter currents. Non-linearity is shown to be important to the energy and volume transport of baroclinic eddy features, but otherwise insignificant. Boundary transport from open lateral boundaries is determined to be of considerable importance to summer circulation and thermal structure, with little effect found for the winter monsoon hydrology. In general, monsoonal circulation patterns and upwelling phenomena are determined and forced by the wind, while boundary transport effects play a secondary role in determining the magnitude of the circulation velocities.


The Polish legislator allows for compensation for the harm suffered due to the death of close person resulting from a tort (for example, a car accident). The basis for such claims is Article 446 § 4 of the Polish Civil Code, which contains a vague expression "the closest family member." Courts must therefore determine whether and how someone was close to someone. The language of the judicial justifications indicates that the courts do not determine proximity solely based on legal criteria. In this publication, I will analyze court decisions in which the scope of the vague expression "the closest family member" has been adjudicated. The analysis aims to establish the legal understanding of closeness in the indicated case and to determine whether and how references to psychology support it.


Diverse forms of the concept of opposition are already existent in philosophy, linguistics, psychology and physics. The inter- play between entities and opposite entities is apparently fundamental for balance maintenance in almost a universal manner. However, it seems that we have failed to incorporate oppositional thinking in en- gineering, mathematics and computer science. Especially, the set theory in general, and fuzzy set theory in particular, do not offer a formal framework to incorporate opposition in inference engines. Considering sets along with their opposites can establish a new com- puting scheme with a wide range of applications. In this work, pre- liminary definitions for opposite fuzzy sets will be established. The underlaying idea of opposition-based computing is the simultaneous consideration of guess and opposite guess, and estimate and opposite estimate, in order to accelerate learning, search and optimization. To demonstrate the applicability and usefulness of opposite fuzzy sets, a new image segmentation algorithm will be proposed as well. Keywords— Fuzzy sets, opposition, opposite fuzzy sets, antonym, antonymy, complement


We consider the limit behavior of a one-dimensional random walk with unit jumps whose transition probabilities are modified every time the walk hits zero. The invariance principle is proved in the scheme of series where the size of modifications depends on the number of series. For the natural scaling of time and space arguments the limit process is (i) a Brownian motion if modifications are "small", (ii) a linear motion with a random slope if modifications are "large", and (iii) the limit process satisfies an SDE with a local time of unknown process in a drift if modifications are "moderate".


Chromatograms of hydrophilic, hydrophobic, and intermediate-polarity analytes were developed in 50-μm capillaries by micellar electrokinetic chromatography at field strengths less than 31 kV/m. The analytes were solubilized by phosphate/borate buffers containing 15, 50, and 100 mM sodium dodecyl sulfate (SDS). The plate numbers N of the analytes, as well as those of the electroosmotic flow and micellar markers, were compared to predictions of N estimated by a simple model based on longitudinal diffusion and plug size. Good to fair agreement between theory and experiment was obtained for the hydrophilic and intermediate-polarity analytes in all buffers over the entire field strength range. Good agreement between theory and experiment was obtained for the hydrophobic analyte and micellar marker in all buffers at low field strengths; however, these compounds were subject to dispersion at higher field strengths by what appears to be Joule heating. The magnitudes of other, closely related Joule heating losses are quantified here using temperature profile measurements by Morris and co-workers and Taylor dispersion calculations. In contrast to the commonly reported increase of N with media concentration, the Ns of the hydrophilic and intermediate-polarity analytes were found to be essentially independent of SDS concentration over the investigated SDS range, and the Ns of the hydrophobic species were found to be independent of SDS concentration until (what appears to be) Joule heating became significant. These results were compared to those of Sepaniak and Cole. A critique of some previous studies of N vs SDS concentration is presented, in which quantitative explanations for some dispersions are offered as alternatives to surfactant concentration effects.


Bargaining with the State examines the threats to liberty that arise through the power of government selectively to distribute benefits and favors to its citizens. For Richard Epstein, the preservation of individual liberty against government contractual power advances not only the short-term interest of the individual citizen but also the long-term overall social welfare.Bargaining with the State examines the threats to liberty that arise through the power of government selectively to distribute benefits and favors to its citizens. For Richard Epstein, the preservation of individual liberty against government contractual power advances not only the short-term interest of the individual citizen but also the long-term overall social welfare.


Introduction
 The CD200/CD200 receptor (CD200R) axis is known to exert immunoregulatory effects in myeloid-derived cells and constitutes a putative immune checkpoint in hematological malignancies, in which CD200 expression is associated with poor prognosis. In multiple myeloma (MM), CD200 is expressed in the majority of patient-derived primary cells. However, its functional importance as well as the related downstream mechanism upon CD200 ligand binding to its CD200R on T cells are not well understood. In this study, we analyze the functional role of CD200 as a potential immune checkpoint in MM and decipher the mechanism of CD200-mediated immune escape.
 Methods
 Primary MM cells and MM cell lines were analyzed for CD200 surface expression by flow cytometry. To overexpress CD200 on non-expressing MM cell lines we used a Sleeping Beauty transposon vector system. CD200+/- MM cell lines L363, U266 and MM.1s were co-cultured with CD3/CD28-activated healthy donor T cells. T cell-mediated cytotoxicity in these co-cultures was assessed with flow cytometry and/or luciferase assay. Moreover, to analyze the effects of CD200R activation on downstream signaling pathways, activated T cells were treated with recombinant human CD200 (rhCD200) and/or anti-CD200 blocking antibody and subsequently, Western blotting was performed.
 Results
 Of n=120 primary MM samples (n=120) analyzed, CD200 protein expression could be detected in ca. 75 % of the cases. In contrast, all n=9 MM cell lines tested neither displayed surface nor cytoplasmic CD200 expression. Therefore, using a Sleeping Beauty transposon vector system we stably expressed CD200 on MM cell lines for further analyses. In the presence of CD200-expressing MM cells up to 50% decrease in CD3+ T cell-mediated cytotoxicity against MM cells was observed in flow cytometry and luciferase assay. Proliferation rates of MM cell lines remained unchanged regardless of the level of CD200 overexpression as determined by Alamar blue assays. In myeloid-derived cells, CD200R directly interacts with docking protein-2 (DOK2). In activated T cells, we observed DOK2 phosphorylation upon CD200 binding when treated with rhCD200 in a time- and concentration-dependent manner. Applying an anti-CD200 blocking antibody, this effect could be reversed, thus revealing a possible mechanism for the observed attenuation of T cell function.
 Conclusion
 Our study shows that anti-MM cytotoxicity from primary healthy donor CD3+ T cells is attenuated by CD200 expression on MM cells. We also demonstrate that this inhibitory mechanism in CD3+ T cells is mediated via DOK2, providing a potential target for immunotherapeutic approaches in MM.

 Einsele: Janssen, Celgene/BMS, Amgen, GSK, Sanofi: Consultancy, Honoraria, Research Funding.


Kant's political theory stands in the social contract tradition, but departs significantly from earlier versions of social contract theory. Most importantly Kant holds, against Hobbes and Locke, that we have not merely a pragmatic reason but an obligation to exit the state of nature and found a state. Kant holds that each person has an innate right to freedom, but it is possible to simultaneously honor everyone's right only under the rule of law. Since we are obligated to respect each person's right to freedom, and can do so only in a state, we are obligated to submit to the authority of the state if we have one, and to establish one if we do not. In the first half of the essay I reconstruct this argument in more detail. In the second half I survey four points of controversy: (i) What is the relationship between Kant's political philosophy and his moral philosophy? (ii) How does the innate right to freedom support the postulate that we are permitted to acquire property and other private rights? (iii) How does the postulate support an obligation to found the state? (iv) How should we understand Kant's views about political revolutions?


Different authoritative accounting and reporting guidelines apply within the healthcare industry. The issue at hand is whether or not the current accounting and reporting framework adequately addresses the needs of those with interests in healthcare financial information.


A well-known contradiction in phase-locked frequency synthesizer design is between frequency resolution, on the one hand, and bandwidth of the phase-locked loop (PLL), on the other. To solve this problem, a technique that uses an algorithm that produces a group of different divide numbers to the programmable feedback frequency divider of PLL for each required output frequency is presented. The interference frequency at the output of the phase detector of PLL and the frequency resolution can then be set independent of each other. High resolution and wide bandwidth are achieved simultaneously, with a simple synthesizer design leading to savings in power consumed and device cost. >


The tools and techniques in contemporary engineering modeling vision tend to change or update the physical and geometrical appearance of structural components attempts to increase the efficiency of sections. Several studies concerning the stability conditions of the dam components were conducted to examine the structural behavior. such as dam performance evaluation after construction especially research's regarding the stability of aging dams, regardless of any studies of the physical form of the dam components. The dam requires three stages in construction. Firstly, is the investigations stage, followed by the design of dam layouts and finally the construction stage. This research concentrates on the second stage which is the design of dam layouts. NonLinear analysis was performed under the requirements of the finite element's method on seven models of an arch dam to explore the structural behavior of the concrete cantilever blocks under the effects of different types of loading. Including investigation on the behavior of a dam concerning multiple intervals of contraction joints. Contraction joints were modeled with seven intervals of distances which are 15m,17.5m, 20m, 22.5m, 25m, 27.5m, and 30 meters respectively. Stresses and displacements response of the body dam structure considered as a structural stability indicator for the tension and compression stresses limitation. Nonlinearity measurement in both materials and configurations of the shape of the dam is used to evaluate a maximum and minimum principal stress along the crown cantilever in both of (upstream, downstream) faces. Also, comparisons include the magnitude of displacement along the crest in both faces. The tools for building an information modeling revit package used for the three-dimensional simulation of a dam. Later the seven models linked to finite element tools Abaqus 6.13 package for discretization's and analysis. The results show that the appropriate selection of contraction joints length increased the structural stability condition of the double curvature dam and reduced the risk of failure, especially near the abutments.


Option market prices have often been regarded as a window on investor sentiment about the future price behaviour of the underlying asset. Such market prices can be different than their corresponding model prices, a phenomenon revealed by implied volatility plots exhibiting "smiles" or "smirks". Using the unique capabilities of Bayesian-based empirical methods, a four-moment risk-neutral specification is determined that largely eliminates market and model price differences. The risk-neutral density derived for a sample of S&P 500 call option prices during 2008-2009 uncovers significant market under-pricing reinforced by anomalous volatility skews that reveal bearish investor sentiment clearly signalling the pending equity market collapse


Creative education cannot be achieved without the creative efforts by the teachers who teach the class. This paper describes what the creativity education means today from the point of view of the teachers who teach the fundamental creative engineering class. The assignments of the exercises in the class are derived from the creative efforts of the teaching staffs. This paper picks up some of the typical assignments of the exercises and shows what kinds of exercises are given to the students. Reviewing the results of these exercises, the paper discusses the advantages and drawbacks of the assignments in the classes for the further improvement in the next semester.


We give a characterization of the internally 4-connected binary matroids that have no minor isomorphic to M(K3,3). Any such matroid is either cographic, or is isomorphic to a particular single-element extension of the bond matroid of a cubic or quartic Mobius ladder, or is isomorphic to one of eighteen sporadic matroids.


CAC-RD (call admission control based on reservation and diagnosis) [1] is call admission control (CAC) for UMTS (universal mobile terrestrial system) 3G networks. It is based on two schemes: channel reservation and network diagnosis. When compared to other CAC mechanisms, CAC-RD can guarantee network availability, reducing priority classes blocking and guarantying some network QoS requirements. Due to computational resource limits, simulations cannot answer related to admission control in big networks with thousands of users. This work presents a method to extrapolate scientific questions like CAC's behavior with thousands of users and many antennas. An artificial neural network (ANN) approach for CAC-RD in UMTS 3G networks is presented. Its main goal is ANN training with the CAC-RD behavior. It is expected that the ANN can answer questions related to real cellular 3G networks admission control.


Abstract. The flow-field-caused aero-optical effect is becoming a crucial issue in hypersonic flight. The degraded imaging results can seriously affect the aircraft's ability to capture targets. Experiments were carried out in a Mach 6-gun tunnel, and the imaging quality of a hypersonic optical dome was investigated under six different values of pressure ratio of jet. Background oriented schlieren was used to obtain the point spread functions (PSFs), which were then used to evaluate the imaging quality of the optical dome. The experimental results showed that cooling film with higher pressure will reduce the support field of the PSF and will have a more severe influence on the imaging quality.


The blackberry crop in the Chuscales and Monteloro regions of the municipality of Trujillo (Valle del Cauca, Colombia) generates 100% of the familiar income. To improve productivity and income of these communities, a diagnostic and development of disease control practices project was undertaken on blackberry cropping systems during a two year period. Frequently, necrotic sports in the foliage were found that did not correspond to symptoms of previously described diseases for the crop; these spots coalesced to completely cover the foliar area resulting in leaf total necrosis. In addition, tissue disintegration was observed in the presence of high humidity. Under field conditions, a 30% incidence was found, though the effects on production were not evaluated. In the laboratory, using culture in selected media, biochemical tests and morphological identification, the presence of non-fluorescent Pseudomonas was determined in samples of blackberry leaves of different ages with necrotic lesions. Additionally, pathogenicity tests were performed in greenhouse and laboratory, using a bacterial a c 108 bacterium/mL and sterile distilled water as control, that reproduced the lesions found in the field and allowed re-isolation of the bacterium.


This paper analyzes the components of the influential Baker and Wurgler (BW) indices of investor sentiment and their contribution to the volatility of U.S. stock portfolios. Using the Klein ? Chow (2013) symmetric method of variance decomposition, we orthogonalize the five proxies of sentiment (dividend premium, first-day return on IPOs, number of IPOs, closed-end fund discount, and equity share in new issues) and determine the proportions of systematic risk contributed by these measures. We find that even portfolios that show no economically significant contemporaneous or lagged sensitivity to the BW indicators may still exhibit important sentiment risk, which raises serious questions about the validity of some of the proxies or the use of Principal Component Analysis to compute the sentiment indices. For instance, after controlling for the Fama ? French three factors and for momentum, for the time interval 07/1965 ? 12/2014, the first-day return on IPOs explains roughly 9.8 and 19.2 percent of the systematic variance of high 10 ? low 10 (long-short) Fama ? French portfolios formed on variance and on accruals, respectively. For the same interval and portfolios, the overall BW sentiment-levels indicator explains, respectively, 1.7 and 0.0 percent of the systematic risk.


The popularity of cloud based applications stemming from the high volume of connected mobile devices has led to a huge increase in Internet traffic. In order to enable easy access to cloud applications, infrastructure providers have invested in geographically distributed databases and servers. However, intelligent and energy efficient high capacity transport networks with near ubiquitous connectivity are needed to adequately and sustainably serve these requirements. In this thesis, network virtualisation has been identified as a potential networking paradigm that can contribute to network agility and energy efficiency improvements in core networks with clouds.
The work first introduces a new virtual network embedding core network architecture with clouds and a compute and bandwidth resource provisioning mechanism aimed at reducing power consumption in core networks and data centres. Further, quality of service measures in compute and bandwidth resource provisioning such as delay and customer location have been investigated and their impact on energy efficiency established. Data centre location optimisation for energy efficiency in virtual network embedding infrastructure has been investigated by developing a MILP model that selects optimal data centre locations in the core network. The work also introduces an optical OFDM based physical layer in virtual network embedding to optimise power consumption and optical spectrum utilization. In addition, virtual network embedding schemes aimed at profit maximization for cloud infrastructure providers as well greenhouse gas emission reduction in cloud infrastructure networks have been investigated. GreenTouch, a consortium of industrial and academic experts on energy efficiency in ICTs, has adopted the work in this thesis as one of the measures of improving energy efficiency in core networks.


ABSTRACT The DNA sensing pathway triggers innate immune responses against DNA virus infection, and NF-κB signaling plays a critical role in establishing innate immunity. We report here that the herpes simplex virus 1 (HSV-1) ubiquitin-specific protease (UL36USP), which is a deubiquitinase (DUB), antagonizes NF-κB activation, depending on its DUB activity. In this study, ectopically expressed UL36USP blocked promoter activation of beta interferon (IFN-β) and NF-κB induced by cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING). UL36USP restricted NF-κB activation mediated by overexpression of STING, TANK-binding kinase 1, IκB kinase α (IKKα), and IKKβ, but not p65. UL36USP was also shown to inhibit IFN-stimulatory DNA-induced IFN-β and NF-κB activation under conditions of HSV-1 infection. Furthermore, UL36USP was demonstrated to deubiquitinate IκBα and restrict its degradation and, finally, abrogate NF-κB activation. More importantly, the recombinant HSV-1 lacking UL36USP DUB activity, denoted as C40A mutant HSV-1, failed to cleave polyubiquitin chains on IκBα. For the first time, UL36USP was shown to dampen NF-κB activation in the DNA sensing signal pathway to evade host antiviral innate immunity. IMPORTANCE It has been reported that double-stranded-DNA-mediated NF-κB activation is critical for host antiviral responses. Viruses have established various strategies to evade the innate immune system. The N terminus of the HSV-1 UL36 gene-encoded protein contains the DUB domain and is conserved across all herpesviruses. This study demonstrates that UL36USP abrogates NF-κB activation by cleaving polyubiquitin chains from IκBα and therefore restricts proteasome-dependent degradation of IκBα and that DUB activity is indispensable for this process. This study expands our understanding of the mechanisms utilized by HSV-1 to evade the host antiviral innate immune defense induced by NF-κB signaling.


The large size of nowadays' online multimedia databases makes retrieving their content a difficult and time-consuming task. Users of online sound collections typically submit search queries that express a broad intent, often making the system return large and unmanageable result sets. Search Result Clustering is a technique that organises search-result content into coherent groups, which allows users to identify useful subsets in their results. Obtaining coherent and distinctive clusters that can be explored with a suitable interface is crucial for making this technique a useful complement of traditional search engines. In our work, we propose a graph-based approach using audio features for clustering diverse sound collections obtained when querying large online databases. We propose an approach to assess the performance of different features at scale, by taking advantage of the metadata associated with each sound. This analysis is complemented with an evaluation using ground-truth labels from manually annotated datasets. We show that using a confidence measure for discarding inconsistent clusters improves the quality of the partitions. After identifying the most appropriate features for clustering, we conduct an experiment with users performing a sound design task, in order to evaluate our approach and its user interface. A qualitative analysis is carried out including usability questionnaires and semi-structured interviews. This provides us with valuable new insights regarding the features that promote efficient interaction with the clusters.


Garnet, an important mineral component in Earth's interior, usually contains minor water as structural OH, but experimental data on OH incorporation in the mineral as a function of chemical and thermodynamic parameters remain rare. In particular, the role of oxygen fugacity (fO2) that is variable in the Earth has not been well assessed. We examine the effects of fO2 on the incorporation of OH at 1–3 GPa and 800–1000°C, by H‐annealing gem‐quality spessartine‐rich, grossular‐rich, and pyrope‐rich garnets. For each type of annealed garnet, the OH peak positions and spectral shapes are the same, suggesting the same OH incorporation mechanism(s). Under identical conditions, spessartine‐rich and grossular‐rich garnets are rich in OH, with solubility orders of magnitudes greater than for pyrope‐rich garnets. Over the studied conditions, the solubility of OH increases with pressure and temperature but decreases with fO2. The negative correlation of fO2 and OH solubility is probably due to the Fe3+ to Fe2+ reduction at more reduced conditions and the coupled OH incorporation in the structure. The effects of fO2 on OH solubility are more significant in Fe‐rich garnets. The ascertained small OH solubility in peridotite garnets, together with comparisons with relevant studies, suggest that mantle garnet is unlikely to be a major water carrier. In combination with literature‐reported positive correlation of fO2 and OH solubility in olivine, the partition coefficient of OH between garnet and olivine in the upper mantle is expected to be redox‐dependent.


Ab initio molecular orbital theory and density functional theory (DFT) procedures have been used to study the binding of methane in CpRe(CO)2(CH4), the simplest σ-alkane complex in the experimentally widely studied CpRe(CO)2(alkane) family. We find the optimal Re···C, Re···H and C···H distances to be 2.60, 1.92, and 1.15 Å, respectively, on the composite-CCSD(T)/def2-QZVPP (CCSD(T)/def2-TZVP with supplement for the larger def2-QZVPP basis set at the second-order Møller-Plesset perturbation theory level) potential energy surface which has been mapped out at this level of theory. The enthalpy of binding at 298 K was determined to be 62.0 kJ mol(-1) at the composite-CCSD(T)/CBS//B3-PW91/aug-cc-pVTZ-PP level. Benchmarks on the various DFT procedures show that some functionals give good geometries but underestimate binding energies, while others yield poor geometries but give closer agreements with the composite-CCSD(T) binding energy. On the other hand, the ωB97X-D functional gives fair agreements with composite-CCSD(T) for both geometry optimization as well as binding energy. Thus, it appears to be a reliable, easily implemented, and cost-effective means for studying Re-alkane complexes. Good binding energies are also obtained with several common functionals when D3 dispersion corrections are applied. Selected dispersion-corrected DFT methods (B3PW91-D3, TPSSh-D3, and B98-D3) were found to be quite accurate for the calculation of binding energies of several other model metal-CH4 complexes containing a range of metal centers (Rh, Pd, W, Ir, Pt). We also note that, for single-point energy calculation of the Re-CH4 binding, the PWP-B95-D3 double-hybrid DFT procedure provides an excellent agreement with the benchmark energy at only a slightly higher computational requirement.


UN peacekeeping is once again undergoing a period of intense critical scrutiny. Having passed through three major phases of development, from first (classical or traditional) to second (multidimensional) generation configurations, to a third phase in the mid- and late 1990s when peace support operations emerged, it currently faces another period of transition. This article speculates about the possible configuration of peacekeeping and its role in global politics. Debates about the role of peacekeeping in the international system should bring to the forefront a conception and practice of cosmopolitan peacekeeping, involving a capacity to protect civilians from violent conflict (the negative peace dimension) and a the capacity to address the human security agenda adopted by the UN in recent years.


The aim of the article is to analyse the foreign experience of the social security system of law enforcement personnel, to distinguish the features of establishing the rates and types of remuneration for law enforcement personnel in foreign countries, to determine the interrelation between the standard of social security and work experience and professional competencies. The subject of the study is the foreign experience of the social security system for law enforcement officials. Methodology. The study is based on a comparison of the social security system for law enforcement officials in Ukraine and in foreign countries. The analysis of the features of social security for law enforcement officers enabled to determine the advantages and disadvantages of different social security systems. A comparative legal study of certain provisions of Ukrainian legislation enabled to reveal the possibilities and limits of the application of positive foreign experience in this sphere. The results of the study revealed that in Ukraine the solution of problems on the performance improvement of law enforcement is interrelated with the issues of social security for personnel at work. Therefore, nowadays one of the main objectives is the development of a clear system of social security for law enforcement officers, including police officers, formation of an effective system of remuneration, based on performance indicators. Practical implications. In developed countries, the practice of social policy has formed several areas of its implementation. These include wage policy, social insurance, including medical, pension insurance, housing policy, as well as allowances and social benefits. Some aspects of social security for employees should be studied as a positive example for Ukraine in the course of social reforms. However, the application of foreign experience does not mean a mechanical transfer of certain forms of social security of foreign countries to Ukrainian reality. It should be considered that some aspects of reforming social security for law enforcement officers are universal; other aspects can be applied only under certain conditions related to the political situation in the country, the level of economic development, traditions, as well as the level of crime and criminalization of society. Relevance/originality. A comparative analysis of the ratio of social security systems for law enforcement officers is the basis for developing the most promising areas of domestic legislation in this sphere.


ABSTRACT
Sarjana Thesis with entitled "Koping Stres Penghayat Kapribaden dalam
Menghadapi Diskriminasi (Studi Kasus di Dusun Kalianyar Desa Ngunggahan
Kecamatan Bandung Kabupaten Tulungagung)" written by Fitri Lutfiani, Student
Registration Number. 2833123004, Advisor Ahmad Sauqi S.Ag, M.Pd.I.
Key words: Coping Stress, Penghayat Kapribaden, Discrimination
This research is motivated by a phenomenon of discrimination experienced
by minority groups that penghayat Kapribaden teachings. Therefore, researcher is
interested in conducting research to determine the stress coping strategies used by
penghayat Kapribaden in facing discrimination in village Kalianyar Ngunggahan
Bandung Tulungagung.
The focus of research in this study were (1) What forms of discrimination
on penghayat Kapribaden in village Kalianyar? (2) How does stress coping
strategies on penghayat Kapribaden in village Kalianyar? (3) How is the
psychological impact inflicted on penghayat Kapribaden in the hamlet Kalianyar ?.
The purpose of this study were (1 ) To determine the forms of discrimination on
penghayat Kapribaden in village Kalianyar (2) To determine the coping strategies
of stress on penghayat Kapribaden in village Kalianyar (3) To know the
psychological impact inflicted on penghayat Kapribaden in village Kalianyar.
This study uses qualitative research with case study approach. Data are
collected through observation, interviews, and documentation. This study uses
snowball sampling technique with 3 subjects in village penghayat Kapribaden
Kalianyar that are subjected to discrimination from society.
The results showed that the forms of discrimination experienced by
penghayat Kapribaden is being sworn, threatened, got innuendos and ostracized by
the community leaders such as kiai and some people because they follow the heresy
and leave the religious laws of Islam. Subjects control by means of problem focused
coping means to immediately take action to solve a problem or find useful
information to help solving the problem. Nevertheless in some cases, the subjects
also use emotion focused coping, which in addition to trying to find answers to the
problem, the subjects were also trying to reduce the pressure to distract him with
some other workload and seek support from others to solve the problem. It has a
psychological impact on subjects such as disturbing the growing confidence in
various social settings, resulting in traumatic, resulting in fear, loss of the ability to
act and a sense of helplessness.


In this paper, a novel cooperative stochastic channel prioritization algorithm is presented for the purpose of improving spectrum sensing efficiency in cooperative cognitive radio systems. The proposed algorithm achieves the goal by prioritizing the channels for fine sensing based on both local statistics obtained by the cognitive radio as well as long-term spatiotemporal statistics obtained from other cognitive radios. Channel priority is determined in a stochastic manner by performing statistical fusion on the local statistics and statistics from neighboring cognitive radios to obtain a biasing density from which stochastic sampling can be used to identify the likelihood of channel availability. Therefore, the individual cognitive radios collaborate to improve the likelihood of each cognitive radio in obtaining available channels. Simulation results show that the proposed cooperative stochastic channel prioritization algorithm can be used to reduce both sensing overhead and percentage of missed opportunities when implemented in a complimentary manner with existing cooperative cognitive radio systems.


This paper aims to fill the gap in major Islamic topics by developing an ontology for the Book of Purification in Islam. Many trusted books start with the Book of Purification as it is the key to prayer (Second Pillar after Shahadah, the profession of faith) and required in Islamic duties like performing Umrah and Hajj. The strategy for developing the ontology included six steps: (1) domain identification, (2) knowledge acquisition, (3) conceptualization, (4) classification, (5) integration and implementation, and (6) ontology generation. Examples of the built tables and classifications are included in this paper. Focus in this paper is given to the design and analysis phases where the technical implementing of the proposed ontology is not within this paper's objectives. Though, we presented an initial implementation to illustrate the steps of our strategy. We make sure that this ontology or knowledge representation on the Book of Purification in Islam satisfy reusability, where the main attributes, concepts, and their relationships are defined and encoded. This formal encoding will be available for sharing and reusing.


DR. HERBERT had studied the tissue-reactions about vitallium cups and acrylic prostheses used in arthroplasty (1952). He stressed their function of transmitting power and weight as well as allowing movement. A secondary operation after cup arthroplasty revealed a lining of smooth fibrous tissue over healthy bone. Necropsy three years after insertion of an acrylic head revealed similar changes at the upper lip-of the femoral stump; but the lower lip presented bone sclerosis and some-cartilaginous metaplasia in its covering, the responses to pressure. No foreign body reaction was evident. A prosthesis should distribute weight widely and equally, and its insertion should be planned from tracings of fullface radiographs of the femoral neck. In drilling for a Judet prosthesis a special apparatus would compensate for the deviation of the axis of the neck from the centre of the head. Contrary to British opinion, Dr. Herbert favoured the vitallium cup in ankylosing spondylitis, and for this alone. Prostheses did not arrest degeneration: they only changed its site.


Abstract Biologically motivated mathematical models, which describe the dynamics of the thrombocytopoietic, granulocytopoietic, and erythropoietic systems in irradiated humans, are thoroughly investigated. These models are the systems of nonlinear ordinary differential equations, whose variables and constant parameters have clear biological meaning. The modeling studies reveal general regularities and peculiarities of the dynamics of the aforementioned hematopoietic lines in acutely and chronically irradiated humans. It is shown that the predictions of the models qualitatively and quantitatively agree with the respective clinical data for humans exposed to acute and chronic irradiation in wide ranges of doses and dose rates. Moreover, the "lethal" dose rate of chronic irradiation, which is evaluated in the framework of the granulocytopoiesis model, coincides with the real minimal dose rate of lethal chronic irradiation for humans. As for the thrombocytopoiesis and erythropoiesis models, the respective "lethal" dose rates of chronic irradiation are very close to the real one for humans. All this bears witness to the validity of employment of the developed models in the investigation and prediction of radiation effects on human hematopoiesis.


Solution processing of conjugated polymers into ordered self‐assembled precursors has attracted great interest in the past years owing to the ability to manipulate their structural and physical properties. Regioregular poly(3‐hexylthiophene) (P3HT) has become the benchmark polymer in this scenario, where ordered lamellar structures significantly improve carrier mobility of the thin films due to increased crystallinity, extended intrachain conjugation, and ordered interchain π‐stacking. Here, a new photoinduced approach is presented for the generation of highly ordered P3HT aggregate structures that is amenable to the use of visible light to control the aggregate formation. Strong intra‐ and interchain interactions in the solution precursors allow for permanent formation of localized and delocalized polarons that are stable for months. Spin‐coated thin films are found to preserve, in part, the morphological and physical properties of the aggregated P3HT solution precursors with high degree of crystallinity and short π‐stack interchain distances.

publisher-specific, author manuscript: http://onlinelibrary.wiley.com/termsAndConditions#am


Theoretical and experimental studies of the interaction of two counterpropagating light waves on dynamic reflection gratings formed in the Denisyuk scheme in cubic photorefractive crystals due to the diffusion mechanism of the charge transfer are considered. The results are presented which demonstrate the possibility of using dynamic photorefractive Denisyuk holograms to design adaptive elements of measuring systems based on optical and fibreoptic interferometers.


AIM
To compare the torsional resistance of XP-endo Shaper (XPS; size 30, .01 taper, FKG Dentaire, La Chaux-de-Fonds, Switzerland) instruments at body temperature with TRUShape (TRS; size 30, .06 taper, Dentsply Tulsa Dental Specialties, Tulsa, OK, USA), ProFile Vortex (PV; size 30, .04 taper, Dentsply Tulsa Dental Specialties) and FlexMaster (FM; size 30, .04 taper, VDW GmbH, Munich, Germany) nickel-titanium rotary instruments.

METHODOLOGY
A metal block with a square-shaped mould (5 mm × 5 mm × 5 mm) was positioned inside a glass container. Five millimetres of the tip of each instrument was held inside the metal block by filling the mould with a resin composite. The instruments were tested for torsional resistance in saline solution at 37 °C. Data were analysed using one-way analysis of variance (anova) and Tukey post hoc tests. The significance level was set at P < 0.05.

RESULTS
FM had the greatest torsional resistance amongst the instruments tested (P < 0.001). There was no significant difference between FM and PV instruments (P = 0.211). The ranking for torsional resistance values was: FM > PV > TRS > XPS.

CONCLUSIONS
FlexMaster and ProFile Vortex instruments were more resistant to torsional stress compared with TRUShape and XP-endo Shaper instruments. The manufacturing process used to produce XP-endo Shaper instruments did not enhance their resistance to torsional stress as compared with the other instruments.


Objective: To investigate the frequency of suicidal ideation in diagnosed pa- tients of schizophrenia. Methodology: This cross sectional analysis was conducted on in-door patient of Department of Psychiatry, Nishtar Hospital, Multan who were diagnosed with schizophrenia from March 2016 to September 2016. One hundred and fifty pa- tients were selected for this purpose in accordance with the inclusion and exclu- sion criteria. Beck scale for suicidal ideation was used to figure out the frequen- cy of suicidal ideation. Data was entered & analyzed by using SPSS version 23.0. Results: A total of 150 patients were selected. Among these, 87 (58%) were male patients and remaining 63 (42%) were females. Mean age of the patients was 28.21 ±5.91 years. Suicidal ideation was found in 38 (25.33%) of schizophrenic patients. Male patients having suicidal ideation were 26/87 (29.88%) and female patients having suicidal ideation were 12/63 (19.04%). Severe suicidal ideation was found in 01 (1.6%) female and 5 (5.7%) male patients. Conclusion: Suicidal ideation was found in a significant number of patients with schizophrenia. Suicidal ideation was more common and more severe in male patients compared to females.


Although ileal pouch-anal anastomosis (IPAA) is the surgical procedure of choice of many patients with ulcerative colitis and other conditions, some patients may require pouch excision (PEx). We aimed to describe our experience with pouch excisions and associated outcomes with an emphasis on late medical, endoscopic, and surgical interventions for inflammatory bowel disease (IBD).

 We performed a retrospective review of a prospective colorectal surgery database. All pouch excisions performed at our quaternary pouch center from 2006 – 2019 were included; pelvic exenteration, PEx with neo-IPAA or Kock-pouch were excluded. Early complications occurred <30 days, late complications >30 days. Medications taken prior to PEx were included if taken within 12 weeks of pouch excision. Data are reported in frequency (proportion) or median (interquartile range).

 A total of 197 cases met inclusion criteria, and were performed by 23 surgeons, median 6 excision (IQR 2 - 14) cases over a 14-year period: of these, 105 had their index pouch created at our quaternary pouch referral center (overall PE rate 2.7%). Indications for PEx are shown in Table 1. Median time to PEx was 7 years and 94 (48%) patients had re-diversion prior to PEx. Medications prior to PEx: 34 (17%) steroids, 27 (14%) biologics, and 22 (11%) immune-modulators. The median duration of surgery was 4 hours (3.2-5). The median estimated blood loss was 263 ml (150-500) with 24 patients (12%) requiring at least one unit of packed red blood cells intra-operatively. Most pouch excisions were done through laparotomy; 2 cases (1%) were started robotically and 11 cases (10%) laparoscopically with a 26% conversion rate. Intersphincteric dissection was used in 172 cases (87%) while 26 cases (13%) required abdomino-perineal resection, of which 58% had a neoplastic indication. Intra-operative, early and late complications are shown in Table 2; 40 patients (20%) had perineal wound complications in less than 30 days, while 26 patients (13%) had long-term perineal wound complications, of which 15 patients required return to the operating room. After PEx, 23 patients out of 167 patients (14%) required continuation of IBD medications, 6 patients (3.6%) required surgery, and 4 patients (2.4%) required endoscopic intervention for their IBD.

 In this large series of ileoanal pouch excisions, we found that perineal wound complications are common, but infrequently require operative intervention. For most IBD patients in this series, pouch excision did appear to be a destination therapy for IBD with a small minority requiring ongoing medical therapy for IBD.


In this paper, medical images are used to realize the Computer-Aided Diagnosis (CAD)
system, which develops targeted solutions to existing problems. Relying on the MiCOM platform,
this system has collected and collated cases of all kinds, based on which a unified data model is constructed
according to the gold standard derived by deducting each instance. Afterwards, the object
segmentation algorithm is employed to segment the diseased tissues. Edge modification and feature
extraction are performed for the tissue block segmented. The features extracted are classified by
applying support vector machines or the Naive Bayesian classification algorithm. From the simulation
results, the CAD system developed in this paper allows the realization of diagnosis and treatment
and sharing of data resources.


Turbulent fluctuations of scalar and velocity fields are critical for cloud microphysical processes, e.g., droplet activation and size distribution evolution, and can therefore influence cloud radiative forcing and precipitation formation. Lagrangian and Eulerian water vapor, temperature, and supersaturation statistics are investigated in direct-numerical simulations (DNS) of turbulent Rayleigh–Bénard convection in the Pi Convection Cloud Chamber to provide a foundation for parameterizing subgrid-scale fluctuations in atmospheric models. A subgrid model for water vapor and temperature variances and covariance and supersaturation variance is proposed, valid for both clear and cloudy conditions. Evaluation of phase change contributions through an a priori test using DNS data shows good performance of the model. Supersaturation is a nonlinear function of temperature and water vapor, and relative external fluxes of water vapor and heat (e.g., during entrainment-mixing and phase change) influence turbulent supersaturation fluctuations. Although supersaturation has autocorrelation and structure functions similar to the independent scalars (temperature and water vapor), the autocorrelation timescale of supersaturation differs. Relative scalar fluxes in DNS without cloud make supersaturation PDFs less skewed than the adiabatic case, where they are highly negatively skewed. However, droplet condensation changes the PDF shape response: it becomes positively skewed for the adiabatic case and negatively skewed when the sidewall relative fluxes are large. Condensation also increases correlations between water vapor and temperature in the presence of relative scalar fluxes but decreases correlations for the adiabatic case. These changes in correlation suppress supersaturation variability for the non-adiabatic cases and increase it for the adiabatic case. Implications of this work for subgrid microphysics modeling using a Lagrangian stochastic scheme are also discussed.


Coffee is one of the most common beverages in the world. However, a sensory lexicon for determining descriptive differences resulting from breeding, agronomic, processing, storage, and brewing modifications is needed. This study developed a sensory lexicon for brewed coffee. More than 100 different coffee samples from 14 countries around the world were used to create this lexicon in four Phases. A highly trained panel assessed all coffee samples using descriptive analysis. The sensory panel identified 110 attributes (many used both for aroma and flavor) and references. Principal component analysis was used to map the scores obtained during the validation phase. For this phase the coffee lexicon allowed the panelists to describe specific characteristics that were present in the coffee samples such as sweet, nutty and fruity notes, as well as the differentiation of notes such as burnt, smoky, astringent, acrid and bitter. The developed attributes and references were successfully used by the trained panel to describe a wide range of coffee samples. The lexicon is considered "living" because additional terms should be added as needed to expand the lexicon to include attributes that are not included here.

Practical applications
The terminology developed during this study is clear, easy to reproduce in future research, and accompanied by reference standards that provide a guide for future studies. This lexicon will provide an important tool for the coffee industry to conduct sensory evaluation to improve the understanding of coffee quality. It is a "living" lexicon that can be added to when samples exhibit notes that were not present in the samples used for this lexicon development.


This article examines the first on-line public offering of shares over the Internet. It considers how such offerings are regulated in the US and whether the current regulatory system in Australia is appropriate to protect investors in a global environment.


BACKGROUND
Recent findings suggest that dopaminergic abnormalities found in psychotic disorders may be secondary to nitric oxide dysfunctions. Nitric oxide seems to influence glutamatergic and dopaminergic neurotransmission, both of which have been associated with psychosis.

OBJECTIVE
To search and review published works which examined the influence of nitric oxide in psychotic disorders subjects.

METHODS
The research was executed in the on-line collections of Pubmed and ISI Web of Science. The key aspects utilized were "Psychotic Disorders AND Nitric Oxide", "Psychosis AND Nitric Oxide","Schizotypal Personality Disorder AND Nitric Oxide", "Delusional Disorder AND Nitric Oxide", "Brief Psychotic Disorder AND Nitric Oxide", "Schizophreniform Disorder AND Nitric Oxide", "Schizoaffective Disorder AND Nitric Oxide", and "Schizophrenia AND Nitric Oxide". Empirical works utilizing human subjects, published in the last 10 years, in English language were included.

RESULTS
Initially, the search yielded a total of 95 studies. Then, 39 were elected according to the inclusion requirements. The selected articles were divided into five groups: biochemical studies (n=15; 38.5%), genetic studies (n=11; 28.2%), postmortem studies (n=6; 15.4%), clinical trials (n=6; 15.4%), and case reports (n=1; 2.5%). The studies evaluated only schizophrenic or schizoaffective disorder subjects. The great majority of them found evidence of nitric oxide dysfunctions in psychosis.

CONCLUSIONS
The results of the review strengthen the idea that nitric oxide has a key participation in psychotic disorders and deserves deeper investigation as a target for future pharmacological intervention.


The paper gives an elementary proof that a finite ring, whose nilpotents lie in the center, is commutative. This result (first proved by I. N. Herstein) is an elegant generalization of Wedderburn's influential theorem that every finite division ring is a field.


Partial discharges occur the biggest failure problem in power cable insulation due to distortion of electrical stress. In this paper, it has been investigated on the effect of spherical nanoparticles of Barium titanate (BaTiO 3) and Clay for enhancing electrostatic field distribution in single and three-core power cables. It has been applied new strategies of nanotechnology techniques for designing innovative polyvinyl chloride insulation materials by using nanocomposites and multi-nanocomposites. Moreover, it has been studied the electrostatic field distribution within power cable nanocomposites insulation in presence of air voids, water voids and cupper impurity voids. The electrostatic field distribution in power cable insulation has been calculated by finite element method (FEM). A comparative study has been investigated on the effect of nanocomposite insulation for enhancing electric field stress in power cables.


Malignant pilomatrixomas are rare tumors of hair matrix origin. Most lesions are localised on the scalp, posterior neck or back. Most patients are middle-aged men. Treatment consists in radical surgical excision, because of frequent local recurrence and possible pulmonary metastasis. Malignant pilomatrixomas are locally invasive, highly recurrent and they are histologically characterised by cytological atypia and frequent mitoses. The case of a 67-year-old woman with an 8 cm tumoral mass on the back is reported. On examination the mass was erythematous-violaceous, indurated, hardly mobile, located on the left suprascapular region. Histological examination after surgical excision was compatible with pilomatrix carcinoma. Laboratory tests, chest X-ray were normal, ultrasound of neck and axillary lymphnodes was negative. The patient is now strictly followed-up at our Day Hospital.


OBJECTIVE
Inter-organizational coordination is important for rehabilitation disaster relief. The 2011 Great East Japan Earthquake and Disaster was unprecedented, being geographically widespread and multifaceted. Faced with the crisis, rehabilitation professionals established the 10 Rehabilitation-Related Organizations of Rehabilitation Support Service (10-RRO). The objectives of this paper are to provide descriptive epidemiology and assess the activities of 10-RRO.

DESIGN
Descriptive.

METHODS
Epidemiological data on disability were collected, mainly from official sources. Relief activities were reviewed from daily reports, and the preparedness, initial response and functioning of 10-RRO were assessed with a questionnaire directed at 36 executives of individual organizations.

RESULTS
The disaster was characterized by a very low ratio of injuries to death of 0.372, and an odds ratio of deaths among disabled persons of 2.32. 10-RRO provided relief activities at 3 shelters. The total number of dispatch days ranged from 107 to 146, and the cumulative number of professionals and evacuees served was 1,202 and 7,300, respectively. Support activities included prevention of immobilization, daily life support, environmental improvement and transition to temporary housing. The questionnaire survey revealed poor preparedness, satisfactory initial response and support activities, and problems of data collection and advocacy.

CONCLUSION
The disaster was characterized by minimal trauma and a great need for preventing immobilization. This first collaborative endeavour was successful.


The global challenge of moving toward a low-carbon energy system heightens the tension between states' economic development efforts and environmental concerns. In Vietnam, increasing energy demand has led to a boom in hydropower development in recent decades. For local communities, dam construction has brought displacement, involuntary resettlement, deteriorating income and living standards, and rising poverty. However, from the central government's perspective, the negative local impacts of hydropower projects are negligible compared to their national benefits. This study uses the construction of the Bản Vẽ hydropower plant to illustrate how government entities expand their control of villagers' livelihoods in the name of environmentalism. Spanning nearly twenty years, our case study reports on changes in the Vietnamese approach to authoritarian environmentalism. The authorities initially promoted voluntary relocation with a brochure depicting the high quality of resettlement areas. When the remaining locals hesitated, because they had heard that the promised new homes had various problems, the authorities forced them to move.
 Overall, the case study shows the Vietnamese authorities deploying different instruments to implement their will, engaging in little meaningful dialogue with local people. Moreover, when locals sought alternative income from acacia plantations, the authorities cited environmental concerns to justify confiscating their forest holdings.


Our paper deals with the simulations of selected admission control methods: Simple sum, Measured
sum, Predicted sum and Hoeffding bound. We focused on finding a new way to improve the properties of the
analysed admission control methods. Primarily, we focused on the parameter of link capacity. Then the results of
the original and proposed admission control methods were compared.


Recognizing the speed limitations of simulating neural networks on single-processor digital computers, this paper  proposes a possible analog circuit approach to the implementation of multiple processing elements for various neural networks. The circuit is interfaced to a standard digital computer for ease of initialization and control, and each artificial neuron features programmable weights and a propagation delay time of less than 500 nanoseconds. The neuron circuit is based on the widely-known McCulloch-Pitts model. The circuit adaptation req u ired for implementation in a Kohonen-type network is also presented. The circuit configurations for the Step and Sigmoid transfer functions are also discussed.


22q11.2 Deletion Syndrome (22qDS) is often complicated by autoimmune diseases. To clarify the causal relationship, we examined the lymphocyte subset distribution and the human leucocyte antigen (HLA) in two female patients (one child and an elderly) with Graves' disease (GD) and 22qDS. Thymus dysgenesis might have contributed to the T-cell imbalance and the lack of negative selection in both cases. Notably, HLA-DR14, a known risk factor for GD in Japanese individuals and the decreased regulatory T-cell numbers that were seen in the pediatric case, may affect the early onset of GD. Central and peripheral tolerance and Th1 cells appeared to be associated with the pathogenesis of GD in 22qDS.


The effect of gamma radiation (0, 0.5, and 1.0 kGy) on firmness and changes in cell wall polysaccharides of mesocarp tissue from refrigerated cucumber pickles was examined. Softening of mesocarp tissue of pickles exposed to 1.0 kGy was a response associated with altered solubility characteristics of pectic substances. Ionizing radiation reduced nonsoluble and alkali soluble pectic substances, while levels of water and chelator soluble pectic substances were increased. Radiation reduced the degree of esterification of pectic substances and increased the amount of bound calcium. Except for a small reduction in galactose caused by 1.0 kGy, levels of other neutral sugars in the cell wall were not significantly affected by any of the treatments.


OBJECTIVE
To identify the factors accelerating the sedimentation rate and to determine whether an excessive quickness may be responsible of the circulatory accident in systemic diseases.

METHODS
The sedimentation rate has been enregistred in 100 patients with systemic diseases known for having a major quickness. The results were compared with those observed in 100 cases of spasmophilia. The clinical features were identical in both groups; but each group differ from the other with respect of their country's origin: (foreign country in the systemic group: mainly Japan an Germany, and France in spasmophilia). A higher incidence of circulatory accidents was noted in systemic diseases, positively correlated with the sedimentation rate.

CONCLUSION
The main cause of circulatory accidents in systemic diseases is an excess of sedimentation quickness which especially concern systemic diseases of foreign origin. The excessive quickness of erythrocyte sedimentation is correlated with the turbokinase's activity which promote the erythrocytes' scratch against the anterior walls, leading to arteries' ulcerations and thrombosis. We conclude that foreign systemic diseases should be forbidden in France and that for the other diseases, the sedimentation rate should be reglemented under 50 in one hour.


Phenylbutyrate (PB) is a potent differentiating agent and currently under investigation for the treatment of prostate cancer (CaP) and other malignancies. We have studied the impact of PB in vitro and in vivo on differentiation, proliferation and apoptosis in the LNCaP and LuCaP 23.1 prostate cancer xenograft models. In vitro we found that i) PB increased PSA secretion/cell, ii) inhibited cell proliferation in a time- and dose-dependent manner resulting in a cell cycle arrest in G1-phase and iii) induced apoptosis at concentrations of 2.5 mM after 3 days of treatment. In PB treated animals tumor growth stabilized or regressed. Combination of castration and PB treatment had a synergistic antiproliferative effect. The growth-inhibitory and differentiating properties and a low toxicity profile of PB provide rationale for further clinical studies in patients with CaP.


The "open innovation" model is currently being touted as a superior path for achieving long-term success. Rather than relying on their own, limited resources for research and development in the traditional, closed invention system, firms are encouraged to share knowledge across firm boundaries to enhance their innovative potential. Yet, such sharing may also have adverse consequences by reducing the rarity of a firm's inventions. This paper accordingly attempts to identify and analyze the parameters that determine whether open or closed types of innovation management are most appropriate for a given firm. Following a contingency perspective, we examine these determinants as various internal and external constraints (situational factors). More specifically, applying concepts related to absorptive capacity, complementary resources, game theory and others, we derive testable propositions and provide case study evidence regarding the value generating properties of open innovation.


THE CONTROL of tetanic muscle spasms and neutralization of the toxin constitute the aims in treatment of tetanus. Firor and his associates 1 have contributed much to knowledge of the use of antitoxin, but treatment of tetanus is still unsatisfactory and there is a wide disparity in therapeutic regimens employed. It is the purpose of this paper to formulate a plan of treatment based on a review of 82 cases from three Detroit hospitals, including 6 cases in which "intocostrin" (contains raw crude curare), and d-tubocurarine in wax and oil were used in treatment. Analysis of the entire series is given in table 1. The mortality rate, somewhat higher than reported in other series, is partially explained in table 2, which reveals 36 deaths occurring within forty-eight hours of the time of admission. Nine of the patients died within ten hours, and 1 died in the admitting room. Table 3