Cervical tuberculous lymphadenitis is a commonly encountered disease, especially in Korea. Differentiation from other metastatic lymphadenopathies and benign conditions such as cystic neck masses is important. CT findings of tuberculous lymphadenopathy in the abdomen and thorax are frequently reported in the literature, though there are only a few articles concerning cervical tuberculous lymphadenopathy. The authors retrospectively analyzed CT findings of 42 cases with cervical tuberculous lymphadenitis regarding distribution, contour, enhancing pattern, changes in the adjacent fascial plane, and dermal and subcutaneous manifestations. We concluded that the following are suggestive of tuberculous lymphadenitis: the presence of conglomerated nodal masses with central lucency, thick irregular rim of contrast enhancement and inner nodularity, varying degree of homogenous enhancement in smaller nodes, dermal and subcutaneous manifestations of inflammation such as thickening of the overlying skin, engorgement of the lymphatics and thickening of the adjacent muscles, and a diffusely effaced fascial plane. There were only a few cases of central low densities with calcifications on CT scan. However, common CT patterns of tuberculous adenitis may also be seen in other diseases, such as lymphoma and metastatic lymphadenopathy, and a thorough clinical examination and detection of primary lesions may be more helpful in differentiating these lymphadenopathies.


This work is devoted to acceleration and upgrade of the CFD code NOISEtte for scale-resolving simulations of compressible turbulent flows using edge-based high-accuracy methods on unstructured hybrid meshes. Attempts to extend the baseline multilevel MPI+OpenMP parallelization towards GPU-based hybrid systems have faced the problem: the code is too complex. It is an in-house research code with plenty of numerical methods, schemes, models, most of which are experimental and are not used in practical simulations. This chaotic zoo leads to excessive conditional branches, switches, redundant functional calls that slow down computations. Although the parallel algorithm is fully adapted to the stream processing paradigm, such an immense amount of code is too difficult to port efficiently to OpenCL or CUDA and maintain it in consistency with the CPU version. An approach to survive in the process of adaptation to hybrid systems has been elaborated. It consists of various components, such as creation of a simplified configurations, combining different stages of the algorithm in order to reduce memory traffic, collapsing multiple functions in one function without branches and switches, mixing single and double precision, etc. As a result, the upgraded code is about twice as fast on CPUs and can use GPUs from different manufacturers AMD, NVIDIA, Intel through the OpenCL standard.


Intravenous infusions with the bisphosphonate compound pamidronate decrease bone pain and reportedly can lead to refilling of dysplastic lesions in adults with fibrous dysplasia (FD) of bone. Here we describe the effects of this treatment approach in 18 children and adolescents (age at start of therapy, 6.2-17.5 yr; eight girls) with polyostotic FD, who received pamidronate for 1.2-9.1 yr (median, 3.8 yr). Treatment cycles with pamidronate (1-1.5 mg/kg.d on 3 consecutive days) were given every 4 months. Levels of serum alkaline phosphatase and urinary collagen type I N-telopeptide were elevated at baseline and decreased continuously during the first 3 yr of therapy. There was no radiographic evidence of filling of lytic lesions or thickening of the bone cortex surrounding the lesions in any patient. Histomorphometric results in dysplastic bone tissue of patients receiving pamidronate (n = 7; time of therapy, 1.4-4.8 yr) were similar to those of patients without medical therapy (n = 9). No serious side effects were noted. In conclusion, pamidronate therapy appears to be safe in children and adolescents with polyostotic FD. However, we found no clear evidence that pamidronate has an effect on dysplastic lesions in such patients.


PURPOSE: to evaluate the prevalence of vulval squamous intraepithelial lesions and associated factors in HIV-infected patients attended at the public health services of Rio de Janeiro city. METHOD: a total of 374 HIV-infected patients were attended at public services in Rio de Janeiro city and submitted to gynecological examination, Pap smear and colposcopic examination of the cervix and vulva. The association of vulval intraepithelial lesion was analyzed according to the results of clinical (age and cervical lesions), laboratorial (CD4 count) and behavioral (number of partners and smoking habit) variables. The study (independent) variables were the epidemiological data, the immunologic status and the results of gynecological propaedeutic. Thus, age, the smoking habit, number of sexual partners, count of T CD4 lymphocites, and cervical intraepithelial lesion were selected. In the beginning, a bivariate analysis was performed, aiming at assessing the association between the presence of vulval intraepithelial lesion (ultimate variable) and the independent variables (age, smoking habits, number of sexual partners, cytology, colposcopy and CD4 count). Thereafter, the results with statistical significance (p<0.05) were submitted to a multiple logistic regression, and the probability ratio with the respective 95% confidence interval was established. RESULTS: the prevalence of vulval intraepithelial lesions was 40%. In the multivariate analysis CD4 count below 500 cells/mm3 OR=2.69 [IC 95%: 1.61-4.52], abnormal colposcopy OR=1.64 [IC 95%: 1.01-2.67] and age under 26 OR=1.98 [IC 95%: 1.18-3.30] were significant. In the vulval and cervical simultaneous lesion subgroup, age under 26 OR=3.30 [IC 95%: 1.65-6.59] and CD4 count below 500 cells/mm3 OR=4.15 [IC 95%: 1.92-8.96], were significant on analysis. CONCLUSIONS: the prevalence of vulval squamous intraepithelial lesions in HIV-infected patients is high. Immunodeficiency, presence of cervical intraepithelial lesions and age under 26 were associated with the presence of vulval intraepithelial lesions.


STUDY OBJECTIVES
The primary objective of our study was to identify clinical issues contributing to delay in the diagnosis of nontraumatic aortic dissection.

DESIGN
Retrospective observational study.

SETTING
A 425-bed community based, university-affiliated teaching hospital.

PATIENTS
Medical records were analyzed for physiologic, clinical, and outcome variables in 32 consecutive patients who presented to our hospital with non-traumatic aortic dissection over a three-year period (1995-1997).

MEASUREMENTS AND RESULTS
The mean time to diagnosis was 10.7 hours (range 0.5-72 hours). The time to diagnosis and clinical variables did not differ between type A and type B aortic dissections (8.7 vs 11.4 hours; P = 0.54). The diagnosis of aortic dissection was not entertained initially in 44% (14/32) of patients, leading to a significant delay in diagnosis compared to patients with suspected aortic dissection on admission (15.0 vs 4.5 hours; P = 0.008). Lack of a widened mediastinum on chest roentgenography (18.7 vs 6.6 hours; P = 0.026) and lack of hypertension (< 140/90 mmHg) at presentation (14.9 vs 7.1 hours; P = 0.03) were associated with a delayed diagnosis of aortic dissection as compared to presence of either finding. The presence or absence of chest or back pain, resting ECG changes, and a past medical history of hypertension did not correlate with time to diagnosis. There was a trend toward earlier diagnosis when the initial diagnostic modality was transesophageal echocardiography as compared to computed axial tomography (CAT) scan (7.7 vs 10.1 hours; P = 0.20).

CONCLUSIONS
Patients with aortic dissection are frequently normotensive and may lack typical chest roentgenographic findings at presentation. A high index of clinical suspicion for aortic dissection is essential to avoid potentially fatal delays in its diagnosis.


Abstract Objective: Only a few benign tumours of the middle ear have been reported to lead to the development of facial palsy. Here, we describe a patient with middle-ear cavernous lymphangioma and facial palsy. Study design: Single case study. Patient: A 61-year-old man presented with left-sided hearing impairment and incomplete left facial palsy. A tumour was confirmed to be occupying the epi- to mesotympanum and to be joined to the facial nerve. The tumour was removed along with facial nerve tissue, which was resected at its horizontal portion, and the remaining facial nerve was fixed by end-to-end anastomosis. Complete facial paralysis occurred after the operation, but the patient's House–Brackmann grade gradually improved to grade III. Post-operative histopathological examination revealed infiltration of the lymphangioma into the facial nerve tissue, together with mild neural atrophy of the facial nerve. Conclusion: These findings suggested that tumour invasion was the cause of facial palsy in this patient.


The paper presents the achievement of the stress and strain intensity in femoral and tibia bones, for different age persons, using two different modern methods. For an exactly value of strain, experimentally obtained, the author has developed an original structure having the main goal to fix the extensometer on the foot skin. It is well known that the human skin does not permit the attachment of a usual inductive extensometer upon it, due to the sliding surface. Using the Finite Element Method, it was possible to take a larger view of the stress and strain state into those two bones, not only in a particular section, as it was made using the extensometer.


Introduction: Our institution is tertiary care centre and referral centre for spine surgery. We like to share the epidemiological parameters of the case treated here.
Methods: This is retrospective, descriptive study conducted from 2013 to August 2018. All the data retrieved from hospital information system of admitted patients and demographic presentations, disease pattern, region of involvement were analyzed.
Result: There were a total of 698 patients. Male were 262(37.5%) and female were 436(62.5%). Age wise distribution ranged from 2 years to 85 years. Maximum numbers of patients were from 31 to 60 years (57.5%) and there were only 3% of cases less than 15 years and above 76 years. 30.2% cases were related to trauma, 29.8% of cases were related to disc pathology, followed by degenerative diseases 13%, infection 9.2%, and 5.4% were of tumors 8.7 % were cases were not classified in the above categories. There were 56.7% cases from lumbosacral region, 16.3% cases from thoracic region, 13.2% cases from cervical region, 5.7% cases were from multiple regions. 0.3% were of generalized nature which could not be classified.
Conclusion: Spinal diseases are more common in female population, more frequent in third to sixth decade of life. Highest numbers of cases were from traumatic cause followed by degenerative disc diseases. Lumbosacral region is most commonly affected.


An important addition to the reference literature of American politics, "The Encyclopedia of the Republican Party" and "The Encyclopedia of the Democratic Party" provide an authoritative survey of the history, evolution and current state of two of the most powerful institutions in the United States. Each encyclopedia is divided into four sections: history; issues and ideology; elections, conventions and platforms; and biographies. The 297 biographies feature the careers of prominent individuals associated with each party, including presidents, vice presidents, governors, senators and representatives, both winning and losing candidates. There are also brief biographies for over 5000 congresspersons and governors. Each encyclopedia, carefully cross-referenced for easy navigation, concludes with several invaluable appendixes, including the constitutions and bylaws of the party, lists of the senate and house leadership, party defectors; party convention sites and dates; names of all party chairpersons; the locations of state party committee headquarters; and a detailed index.


Along with the times and the increasing economy of the community, the demand for safe and comfortable housing is increasing. As well as the use of the internet that without us realizing it is present in our daily lives makes us a society that is in the IoE (Internet off Everything) cycle, so I am interested in developing a remote monitoring technology for Arduino-based residential conditions with the concept of Internet Off Thing, discussing regarding the workings of the Arduino connection which is controlled through the website as a step in implementing the internet off thing. Using Wifi, direct computer and Arduino. With the writing of this article, it is hoped that further developers, both academic and non-academic, can know and learn the concept of a combination of remote monitoring systems for Arduino-based residential conditions and Internet Thing in a more interactive way, although the author realizes that there is still much to be improved and developed. from the article that the author made this.


This paper provides models for managing and investigating the power flow of a grid-connected solar photovoltaic (PV) system with an energy storage system (ESS) supplying the residential load. This paper presents a combination of models in forecasting solar PV power, forecasting load power, and determining battery capacity of the ESS, to improve the overall quality of the power flow management of a grid-connected solar PV system. Big data tools were used to formulate the solar PV power forecasting model and load power forecasting model, in which real historical solar electricity data of actual solar homes in Australia were used to improve the quality of the forecasting models. In addition, the time-of-use electricity pricing was also considered in managing the power flow, to provide the minimum cost of electricity from the grid to the residential load. The output of this model presents the power flow profiles, including the solar PV power, battery power, grid power, and load power of weekend and weekday in a summer season. The battery state-of-charge of the ESS was also presented. Therefore, this model may help power system engineers to investigate the power flow of each system of a grid-connected solar PV system and help in the management decision for the improvement of the overall quality of the power management of the system.


We present in this paper an adaptive security model for Multi-agent systems. A security meta-model has been developed in which the traditional role concept has been extended. The new concept incorporates the need of both security management as used by role-based access control (RBAC) and agent functional behaviour in agent-oriented Software Engineering (AOSE). Our approach avoids weaknesses of traditional RBAC approaches and provides a practically usable security model for multi-agent systems (MAS). A unified role interaction model framework has been put forward that incorporates not only functional requirements but also security constraints in MAS. A security policy rule scheme has been used to express security requirements in relation to affective roles. The major contribution of the work is that little redevelopment effort will be required when security is to be engineered into the overall MAS architecture, hence minimising the impact of the security requirements changes to the MAS architecture. We illustrate the approach through its potential application in a clinical trial setting involving a prototype medical decision support system, HealthAgents.


BACKGROUND
In the operative treatment of idiopathic hydroceles the available techniques are frequently not selected as indicated according to the different expansions of hydroceles but rather the accustomed procedures are used.

MATERIAL AND METHODS
In a retrospective analysis the methods and complications of hydrocele operations were evaluated.

RESULTS
From 1988 to 2008 195  hydroceles in 191  patients were operated upon: 22 (11.3 %) by eversion (according to Jaboulay), 27 (13.8 %) by resection (according to von Bergmann) and 146 (74.9 %) by a combination of resection and eversion (according to Kocher) of the tunica vaginalis communis. In 14 (7.2 %) patients the operation was indicated by a recurrent hydrocele, either after an eversion alone (n = 7) or after an insufficient resection (n = 7) of the tunica vaginalis communis. As complications of the operation an abscess occurred in 4 (21 %) cases, a haematoma in 5 (2.6 %) cases and a combination of both had to be reoperated in 2 (1.0 %) cases.

CONCLUSIONS
In order to prevent recurrent hydroceles the available methods for the operative treatment of idiopathic hydrocele should be selected according to the different expansions of the hydroceles and as such consequently executed.


The electrostatic properties of genome DNA influence its interactions with different proteins, in particular, the regulation of transcription by RNA-polymerases. DEPPDB--DNA Electrostatic Potential Properties Database--was developed to hold and provide all available information on the electrostatic properties of genome DNA combined with its sequence and annotation of biological and structural properties of genome elements and whole genomes. Genomes in DEPPDB are organized on a taxonomical basis. Currently, the database contains all the completely sequenced bacterial and viral genomes according to NCBI RefSeq. General properties of the genome DNA electrostatic potential profile and principles of its formation are revealed. This potential correlates with the GC content but does not correspond to it exactly and strongly depends on both the sequence arrangement and its context (flanking regions). Analysis of the promoter regions for bacterial and viral RNA polymerases revealed a correspondence between the scale of these proteins' physical properties and electrostatic profile patterns. We also discovered a direct correlation between the potential value and the binding frequency of RNA polymerase to DNA, supporting the idea of the role of electrostatics in these interactions. This matches a pronounced tendency of the promoter regions to possess higher values of the electrostatic potential.


Microbiology![Figure][1]

Viruses can affect the metabolism of cyanobacteria.

PHOTO: STEVE GSCHMEISSNER/SCIENCE SOURCE

Essentially all organic material derives from photosynthesis. The most numerous photosynthetic organisms are marine picocyanobacteria, which synthesize about 10% of Earth's organic compounds. Even more numerous marine viruses prey on picocyanobacteria. Putty et al. show that the infecting viruses subvert the metabolism of their picocyanobacteria hosts, boosting the energy-producing reactions of photosynthesis to support viral infection. At the same time, they inhibit the ability of picocyanobacteria to fix CO2 and synthesize organic material, therefore having a potentially substantial effect on global amounts of organic compounds.

Curr. Biol. 10.1016/j.cub.2016.04.036 (2016).

 [1]: pending:yes


The 1857 Rebellion has been an unforgettable episode in Indian history and has been a well-documented subject in Indian Archives. Most accounts of the Rebellion—published in volumes of anthologies—hardly follow its aftermath and the way convicts were deported to offshore prisons. Following the Mutiny, the Government sought to transport 'rebel convicts' to stabilize the Empire. The Andaman Islands was inspected and subsequently a penal settlement in the Andamans started operating. Starting 1858 till 1942 (Japanese occupation of the islands), the Empire negotiated with approximately 13,000 Indian convicts to form an elaborate convict society in the penal settlement. The incarceration of political prisoners starting 1909 changed the history of the settlement and the Andamans, as a penal settlement, is gradually nationalized as part of Indian freedom struggle. Divided into six chapters, the thesis suggests that (auto)biographical narratives of the prisoners incarcerated in the Andaman jails are crucial sites that contest and invert colonial and national historiography and nativize the Andamans to a significant extent. The thesis reads colonial documents and (auto)biographical narratives of select political prisoners to locate a narrative history of the penal settlement. How do (auto)biographical narratives correspond, negotiate, contest and invert colonial history? How do these narratives present the corresponding period of incarceration and put forward a political current of the contemporary period? The thesis maps penal historicity and locates the genesis of an alternative national consciousness in Andaman penal texts in the form of a strong resistance movement. In addition, it argues that the penal narratives under study generate an elaborate national consciousness to invert contemporary Gandhian nationalist discourse. Part-archival and part-literary, the study explores and interprets colonial documents alongside native (auto)biographical texts for a comparative analysis of native and imperial views on the penal culture.


Assessing maximal oxygen uptake (VO2 max) is generally considered safe when performed properly for most adolescents; however, for adolescents with type 1 diabetes mellitus (T1DM), monitoring glucose levels before and after exercise is critical to maintaining euglycemic ranges. Limited guidance exists for glucose level recommendations for the pediatric population; therefore, the purpose of this retrospective clinical chart review study was to determine the effects of VO2 max testing on blood glucose levels for adolescents with T1DM. A total of 22 adolescents (mean age = 15.6 ± 1.8 years; male = 13, 59.1%) with a diagnosis of T1DM participated in a Bruce protocol for VO2 max from January 2019 through February 2020. A statistically significant reduction in glucose levels between pretest (<30 min, mean = 191.1 mg/dL ± 61.2) and post-test VO2 max (<5 min, mean = 166.7 mg/dL ± 57.9); t(21) = 2.3, p < 0.05) was detected. The results from this current study can help guide health and fitness professionals in formulating glycemic management strategies in preparatory activities prior to exercise testing and during exercise testing.


This paper reports a novel 3D surface modeling method based on nonlinear auto-regressive moving average with exogenous input (NARMAX) in time domain - 3D surface modeling based on spatial neighbor points coupling (SMSNPC) for scattered data points. The 3D model of complex surface can be reconstructed through the mutual coupling of neighbor points. The algorithm of adjustment for model parameters is introduced in this paper based on ANN. To demonstrate the efficient applicability of the developed prototype, two groups of point cloud data are presented. One collected by the robot measure system is used to validate the reconstruction result and the other is used to compare with conditional non-coupling ANN modeling in reconstruction precision. From the results, the new approach presented in this paper validates the expectation that the surface modeling based on spatial neighbor points can match the real surface satisfactorily and it is particularly suitable for modeling of complex surface which cannot be finished by non-coupling ANN modeling. And from the comparative studies it is shown the reconstruction precision of SMSNPC is much higher.


Glory to Allah, water is a mercy and grant from Allah praise be unto thee the almighty. al-Quran explains that water is source of life where Allah stimulate growth and breed plants and animals with water. It has different cristal geometry depend on treatment. The crystal is looked beautiful, is we always say repeatedly chant part of the confession of faith. On the other hand, the crystal is looked bad. If we always say curses and obscenities. Glory to Allah, Acording to chemistry water has formula H2O molecule that has a bundle of hydrogen. It is as a proven of Allah the cherisher and sustainer of the world. Without a bundle of hydrogen in water, water will melt aroun -100oC and boil -90oC. In short, we have never seen and found water again and it has happened juggement day.


We present an optical mapping near-eye (OMNI) three-dimensional display method for wearable devices. By dividing a display screen into different subpanels and optically mapping them to various depths, we create a multiplane volumetric image with correct focus cues for depth perception. The resultant system can drive the eye's accommodation to the distance that is consistent with binocular stereopsis, thereby alleviating the vergence-accommodation conflict, the primary cause for eye fatigue and discomfort. Compared with the previous methods, the OMNI display offers prominent advantages in adaptability, image dynamic range, and refresh rate.


This paper is a review article on the impacts of technology adoption on agricultural productivity in smallholder agriculture in the sub-Saharan African region. The use of agricultural technologies determines how the increase in agricultural output impacts on poverty levels and environmental degradation. Experience and evidence from countries within and around the sub-Saharan African region indicate that returns to agricultural technology development could be very high and far reaching. The factors affecting technology adoption are assets, income, institutions, vulnerability, awareness, labour, and innovativeness by smallholder farmers. Technologies that require few assets, have a lower risk premium, and are less expensive have a higher chance of being adopted by smallholder farmers. There are certain traditional smallholder agricultural technologies in sub-Saharan Africa that also have their own merits. Some of these technologies are more efficient in their use of scarce production resources than modern technologies. Modern researchers should therefore seek to understand the rationale behind traditional smallholder farmer behaviour in technology use. This will make their future technological interventions in smallholder agriculture more effective.


Background Only mentally capable persons can complete advance directives (ADs). When persons without ADs are hospitalised and are thought to have questionable capacity, care providers may not trust the ability of those patients to make their own treatment decisions. Such situations can frustrate treatment decision-making and cause moral distressing situations. Some hospitalised patients with questionable capacity, however, may be able to participate in some basic advance care planning (ACP). This is because the skills necessary to do ACP vary based the preferences being discussed and the level of cognitive functioning needed to make certain decisions. As Appelbaum (2007) notes there are no formal practice guidelines for assessing a person's capacity, and may require an interprofessional approach. Since patients should be permitted to participate with decision-making to the extent possible, hospitalised patients with questionable capacity should not automatically be disqualified from doing basic ACP in hospital settings. Aim This presentation identifies and describes a viable approach that clinicians can use in hospital settings to help assess patients with questionable capacity, thereby providing a way for patients to do basic ACP in hospital settings while engaging in treatment decision-making to the greatest extent possible. Methods A process that utilises interprofessional collaboration will be detailed toward assessing the mental functioning of hospitalised patients with questionable capacity. Several cases using this method will be discussed. Results N/A Discussion N/A Conclusion Assisting hospitalised patients with questionable capacity do ACP is complicated. Developing a systematic approach toward capacity assessment helps distinguish when patients should and should not perform basic ACP in hospital settings.


The design and optimization of BiCMOS buffer chains and multi level logic circuits are reported. BiCMOS speedup contours are introduced and analytical expressions for the delay are obtained. The speedup contours and the delay expressions were used in the design and optimization of BiCMOS buffer chains. Also, general design guidelines, which can be easily automated, for circuit design in a BiCMOS environment are given. Designing multistage mixed CMOS/BiCMOS buffers, BiCMOS complex logic gates, and multi level CML (current mode logic) gates is also studied. >


In modern digital communication noise plays an important role. It essential to minimise the amount of noise added in the communication channel. The signal quality can be enhanced, by modelling the channel at the receiver, by means of equalization. Given large number of users employed in the system over multipath channels causing significant multiple-access interference (MAI) & inter symbol interference (ISI), the optimal MUD is thus prohibitively complex. Hence the sub-optimal detectors such as low-complexity linear & non-linear equalizers have to be considered. In this paper, recursive least square (RLS) adaptation algorithm for adaptive decision feedback turbo equalizer (ADFTE) is proposed. Along with the application of the adaptive method to the DFE-RLS equalizer, turbo-principle can easily be applied. The performance of the system is improved in the fashion of exchanging the extrinsic information iteratively among the soft-input/soft-output (SISO) equalizer & SISO channel decoder until convergence is achieved. The proposed turbo equalization implements the LOG-MAP (maximum a posterior) exclusively for both equalization & decoding. At each iteration, the estimated symbol is then saved as a priori information for next iteration. The simulation results shows that the proposed algorithm for DFE & turbo decoding offers performance gain improvement of 0.7 dB over the DFE-LMS.


Purpose: Accurate localization and monitoring of prostate position during radiation therapy is critical for the precise and safe delivery of dose‐escalatedtreatments, but is challenging due to substantial internal‐organ motion. A novel method for tracking prostate position using implantable radiofrequency markers has been developed by Calypso® Medical. An important consideration for these transponders is localization accuracy using computed‐tomography (CT)imaging. We evaluated the accuracy and precision of transponder localization using multislice CT scanning.Method and Materials: A tissue‐equivalent pelvis phantom with three implanted transponders and external alignment markers was used. The relative transponder positional accuracy was 0.1mm, while the positional accuracy of the transponders relative to the phantom surface was 0.5mm. The phantom was placed on a computer‐controlled linear stage and multiple scans were acquired using a Philips Brilliance 16‐slice CT scanner, varying the detector size, slice thickness, and pitch. Scans were repeated with the phantom moved 0.5mm longitudinally between scan acquisitions to assess position‐measurement accuracy at different locations within a reconstructedCT slice thickness. The transponders were identified and localized on the reconstructedCTimages automatically using in‐house image processing software. Results: The mean error of the transponder localization was less than 0.4 mm in anterior‐posterior and lateral‐medial directions, and increased to 0.8mm in longitudinal direction primarily due to the uncertainty introduced in the initial slice identification. The predicted longitudinal shift between each consecutive scan followed the actual shift amount accurately with a mean error of 0.014mm and a standard deviation of 0.08mm. Conclusion: Our investigations have demonstrated the high accuracy of the transponder localization using a multislice CT scanner. The initial results indicate that the accuracy of such a system is sufficient for prostate localization and position monitoring in clinics. Conflict of Interest: This work is supported in part by Calypso® Medical.


Background and Aims
Ulcerative colitis patients display increased numbers of circulating pro-inflammatory monocyte human leukocyte antigen-DR [HLA-DRhi] monocytes expressing high levels of the gut-homing C-C chemokine receptor 9 [CCR9] and tumour necrosis factor [TNF]-α. The aim of this first-in-human, double-blind, randomised, placebo-controlled trial was to evaluate selective removal of circulating CCR9-expressing monocytes by leukapheresis in patients with moderate to severe ulcerative colitis, with regards to safety, tolerability, and immunological response.

Methods
Patients with ulcerative colitis were treated every second day with leukapheresis during five sessions with a C-C chemokine ligand 25 [CCL25; CCR9 ligand] column or a placebo column.

Results
No major safety concerns were raised and the procedure was well tolerated. Pro-inflammatory HLA-DRhi cells decreased significantly in the active treatment group [p = 0.0391] whereas no statistically significant change was seen in the placebo group [p = 0.4688]. There was a significant decrease of HLA-DRhi monocytes in the active group compared with the placebo group when corrected for the imbalance in weight between the groups [p = 0.0105]. Mayo score decreased in the active group [p = 0.0156] whereas the change in the placebo group was not significant [p = 0.1250]. Mayo score ≤ 3 was observed in five out of 14 patients [35.7%] in the active group compared with one out of eight [12.5%] receiving placebo. The number of responders in the active treatment group was eight out of 14 patients [57.1%], whereas in the corresponding placebo group three out of eight patients [37.5%] responded to placebo. A dose-response correlation was observed between the blood volume processed and clinical outcome.

Conclusion
This clinical induction trial using CCL25-tailored leukapheresis demonstrates a safe and effective removal of activated monocytes with a clinical effect in patients with ulcerative colitis.


As the title suggests, this is yet another work on dowry, this time in Maharashtra. Despite being recognised as a 'social evil' and abolished in theory, the practice continues even today. The author undertakes to view the practice in a different context-as a specific node within a dynamic system of exchanges between an urban (Pune) and a rural (a village in Shirur district) milieu. The work is called a social anthropology of marriage and traces the evolution of the practice of dowry in Maharashtra, the ethnographic composition of the district studied, the caste hierarchies, the rhythm of the seasons and the 'time of marriage', the rituals connected with the exchange of gifts and the marriage ceremony itself, 'sanskritisation' of the practices described, and the changing conceptions of dowry among classes and across the rural-urban divide. A sterling feature of the book is the analysis Benei has done of rituals connected with three types of marriages-Muslim, Marwari, and caste Hindu (Brahmin). (pp.174-84).


The degradation kinetics of propylene glycol butyl ether (hereafter referred to as PGBE) ester of 2-(2,4,5-trichlorophenoxy) propionic acid (silvex) and the persistence of silvex in water and sediment were studied under impounded conditions. PGBE ester of silvex was applied to the surface of three ponds at the rate of 9 kg/ha/A. Water and sediment samples were collected at 4, 12, 24, and 48 hr after treatment and were extracted for PGBE ester of silvex immediately after collection. The concentrations of PGBE ester of silvex and silvex present in the water and sediment samples were determined by gas chromatography. Physico-chemical and mineralogical characteristics of the sediment samples collected prior to treatment were determined. The hydrolysis of PGBE ester of silvex to silvex obeyed first order reaction kinetics, the specific reaction rate constants for the three ponds being 0.09 hr−1, 0.10 hr−1, and 0.14 hr−1. Fifty percent hydrolysis of PGBE ester of silvex occurred in 5 to 8 hr, 90% hydrolysis occurred in 16 to 24 hr, and 99% hydrolysis occurred in 33 to 49 hr. The concentration of silvex in water initially increased, but decreased to zero by the end of 3 weeks. Adsorption of both the PGBE ester of silvex and silvex appeared to occur on the sediment; essentially complete disappearance of both occurred by the fifth week following treatment. Under laboratory conditions, silvex adsorption by the sediments conformed to the Freundlich adsorption equation.


Although microbial biochemistry shapes a dynamic environment in the gut, how bacterial metabolites such as hydrogen sulfide (H2S) mechanistically alter the gut chemical landscape is poorly understood. Here we show for the first time that H2S generated during cysteine metabolism drives the reduction of azo (R-N=N-R') xenobiotics in bacterial cultures, human fecal microbial communities, and in vivo mouse models. Thus, chemical-chemical interactions, derived from microbial community metabolism, are a key missing feature shaping xenobiotic metabolism in the gut. Changing dietary levels of the H2S xenobiotic redox partner Red 40 transiently decreases mouse fecal sulfide, confirming that a xenobiotic can attenuate sulfide concentration in vivo. Cryptic H2S redox thus modulates sulfur homeostasis in the gut and the fate of xenobiotics to which humans are regularly exposed.


This study assessed dietary diversity, its relation to micronutrient intake and variability between age-groups among women 19–69 years from informal settlements of Gauteng province, South Africa. The study was cross-sectional, involving 260 women. Dietary intake was obtained from 24-hour recall data, and Dietary Diversity Score (DDS) from Food Frequency Questionnaire, calculated based on 9 food groups and 80 foods. Intake of eleven micronutrients was assessed as Nutrient Adequacy Ratios (NAR) and Mean Adequacy Ratios (MAR), using Estimated Average Requirements and Adequate Intakes of these micronutrients, following Institute of Medicine recommendations. On average, 26 foods and 7 food groups were consumed. There was a strong significantly positive relationship (p<0.001) between the NAR of respective micronutrients (as well as MAR) with the DDS, the relationship was negative with food variety and diversity within food groups; except for vitamin C. Age-group comparisons revealed the older age groups (36-years and older) being at-risk of low micronutrient intake; particularly in calcium, vitamins C and A. In conclusion, dietary diversity was above reference, there was a strong relationship between DDS and micronutrient intake, and there is a significant variation in intake between age-groups, with women 36-years and older being more at-risk of low micronutrient intake.

 Key words: Dietary diversity, informal settlements, micronutrients, nutrient adequacy, nutrition education.


The ability of Vertical and/or Short Take-Off and Landing is the objective of advanced fighter and shipboard fighter. In this paper we proposed a prototype of tailless configured STOVL aerial vehicle. Based on which, the mathematical model was studied by mechanical analysis and CFD (Computing Fluid Dynamics) computation. Besides, an intelligent adaptive based control law was proposed and the optimization approach is employed to solve the constrained control allocation problem. The results show good closed loop performance and validate the intelligent optimization approach of constrained control allocation for flight control.


MECHANICAL STRESS MODULATES EXPRESSION OF TOLL-LIKE RECEPTORS IN HUMAN PDL CELLS Yaroslav R Yarmolyuk, DDS Marquette University, 2012 Orthodontic movement of teeth with compromised periodontium is risky because heavy orthodontic force could exacerbate the damaged periodontal status. Guidelines for moving periodontally-compromised teeth have not been established due to the lack of scientific evidence about the relationship between periodontal inflammation and mechanical force. In periodontitis, lipopolysaccharide (LPS) is recognized in the periodontal ligament (PDL) by tolllike receptors (TLR) which lead to destruction of periodontal tissues through inflammatory cascades. Recent studies have demonstrated that absence of TLR2 and TLR4 leads to reduced alveolar bone loss in mice. Therefore, reduction of TLR2 and TLR4 on PDLF cells can have a protective effect against the attack by periodontal pathogens and, accordingly, decrease susceptibility to periodontal disease. The objective of the study was to explore the effect of mechanical stress on the expression of toll-like receptors on human periodontal ligament fibroblasts (hPDLF).Human periodontal ligament fibroblasts (hPDLF) were cultured on glass slides. Upon confluence, the cells were starved for 24 hours and then subjected to fluid shear stress (FSS) of 12 dynes/cm for 1 hour. After FSS, the cells were lysed to test the phosphorylation of extracellular regulated kinase (ERK)1/2 and the expressions of TLR2 and TLR4. To explore the possible involvement of ERK1/2 signaling pathway, a specific ERK1/2 inhibitor PD98059 was added during the flow. The whole cell lysates from each group were immunoblotted with anti-TLR2 and anti-TLR4 antibodies. The signals of interest were determined using the ECL method. For quantification, densitometries of gel bands of interest were normalized to that of vinculin. One-way ANOVA with Tukey's post hoc test was used to compare the results among the experimental groups, with p value being set at 0.05. As found, TLR4 but not TLR2 was abundantly expressed in hPDLF cells. Compared to the static controls, FSS significantly reduced the expression of TLR4. When PD98059 was added, the FSS-induced reduction of TLR4 was significantly recovered back to the control level. Conclusively, mechanical stress downregulates the expression of TLR4, which is mediated by MAPK (ERK1/2) signaling pathway. Our findings suggest that FSS (mimicking light orthodontic force application) could possibly alleviate the compromised periodontal status via down-regulation of TLR4.


Abstract This paper presents the integration and channel characterization of a highly integrated dual-band digital beamforming space-borne synthetic aperture radar (SAR) receiver. The proposed SAR sensor is a low-cost, lightweight, low-power consumption, and dual-band (X/Ka) dual-polarized module ready for the next-generation space-borne SAR missions. In previous works, by the authors, the design and experimental characterization of each sub-system was already presented and discussed. This work expands upon the previous characterization by providing an exhaustive experimental assessment of the fully integrated system. As it will be shown, the proposed tests were used to validate all the instrument channels in a set-up where the SAR sensor was illuminated by an external source minim the ground reflected waves. Test results demonstrate how the system channels are properly operating allowing the reception of the input signals and their processing in the digital domain. The possibility to easily implement a calibration procedure has also been validated to equalize, in the digital domain, the unavoidable amplitude differences between the different channels.


Mechanistic investigations into the physiological and biochemical differences between patients have only recently begun to help explain what was previously categorized as "intersubject variability." Additional factors, including the particular drug formulation or delivery system, have been implicated in observed sex-based and race-based differences in pharmacokinetic response. Drug absorption following intramuscular injection can be highly variable if the injection is mistakenly placed in the overlying tissues, a situation that is more likely to occur in women than men. Slower gastric emptying in women can significantly delay the onset of effectiveness of enteric-coated dosage forms, and differences in gastric pH can affect the drug solubility and dissolution rate. Slower drug release rates designed into many extended release dosage forms interact with the differential locations and populations of intestinal and hepatic transporters and metabolizing enzymes to cause significant sex-based and race-based differences in plasma drug concentrations. Increased efforts to identify and understand the interplay of an individual's physiological makeup, dietary intake, environment, and the drug products he or she uses are needed to be able to provide optimal drug therapy regimens to each patient.


Here we demonstrate that influenza virus replication, host responses to infection, evolution through mutation or gene reassortment, and clinical efficacy of antiviral drugs can be reconstituted in a human Airway Chip microfluidic culture device. Modeling human-to-human transmission of infection in the continued presence of antiviral drugs on chips led to the emergence of clinically prevalent mutations responsible for amantadine- and oseltamivir-resistance, as well as the discovery of new resistance mutations. Analysis of infection responses resulted in identification of host therapeutic targets and demonstration that existing non-antiviral drugs may be repurposed to inhibit viral replication and synergize with antiviral therapeutics by targeting the host response to infection rather than the virus itself. This Influenza Chip may represent an alternative preclinical tool for development of new antiviral drugs and vaccines. One Sentence Summary New drug resistance mutations and potential tolerance-inducing therapeutics were discovered using an organ chip model of influenza infection.


The general nerar-field acoustic holography (NAH) cannot reconstruct the surface acoustic information of each coherent acoustic source in coherent acoustic field,which has more than one acoustic sources with the same frequency, and they cannot realize holographic reconstruction and prediction of the independent acoustic field generated by one coherent acoustic source too.So the holographic reconstruction and prediction of coherent acoustic field has become the foremost problem to be resolved in the application of NAH. On the basis of the proposed combined wave superposition approach, an experiment is carried out to realize the holographic reconstruction and prediction of a coherent acoustic filed generated by two sound boxes.By this experiment,the feasibility and accuracy of combined wave superposition approach are demonstrated,the shortcoming of general wave superposition approach in holographic construction and prediction of coherent acoustic field are also demonstrated.The Tikhonov regularization method is proposed to control the ill-posedness of inverse acoustic problem, and the principle of filter coefficient selection is also studied.The experiment indicates that Tikhonov regularization method with appropriate filter coefficient can improve the precision of the holographic reconstruction and prediction.


This survey establishes a chronological trace of the entrepreneur as treated in economic literature in order to give a more wholesome perspective to contemporary writings and teachings on entrepreneurship. The authors review the historical nature and role of the entrepreneur as revealed in economic literature from the 18th century to the present. This survey shows the ambiguous nature of a concept that, due to Schumpeter's dominant influence, has come to occupy a primary role in the theory of economic development. In addition, there are other conceptions of entrepreneurship presented besides Schumpeter's. This historical survey also illustrates the tension that often exists between "theory" and "practice." We shall learn that it has been difficult for economic theory to assimilate a core concept that plays a vital role in social and economic change. Finally, the authors expose the many different facets of entrepreneurship as they have been perceived by some of the great economists throughout the ages.


History A 53-year-old woman presented to the hospital for evaluation of progressive long-standing left dorsomedial foot pain, which was made worse with weight bearing. There was no history of trauma. Prior assessments were performed at another facility, and she did not to respond to conservative therapy. History was negative for systemic disorders. Physical examination revealed tenderness over the left talonavicular joint and flattening of the medial arch of the left foot. Otherwise, the findings were unremarkable. A basic serum chemistry test and complete blood count revealed no abnormal findings. The patient underwent routine weight-bearing radiography of her left foot and weight-bearing computed tomography (CT) of both feet.


Liquefied Natural Gas (LNG) fuelled system has received increasing attention from the shipping industry. However, the main barriers such as high capital investment costs required by LNG fuelled ships, uncertainties in LNG supply and price are still hinder the uptake of LNG as a marine fuel, especially for the trans-ocean going application. Also, uncertainties brought by unexpected events such as war and global pandemic, force us to revisit the topic of economic feasibility of the alternative emission reduction technologies. A lifetime-based cost evaluation framework has been proposed to systematically evaluate the implementation of using LNG as fuel for general ocean-going commercial ships. The benefits of the approach were discussed through a case study and the economic performance of the three varying sizes of ocean-going LNG-fuelled container ships were tested. Uncertainty analysis has been conducted with Monte Carlo simulation to evaluate the economic feasibility of using LNG as marine fuel under different fuel price scenarios. Case study and uncertainty analysis indicated that the acquisition premium for ocean-going LNG-fuelled container ships is sufficient to warrant the saving in terms of the LCC. Nevertheless, under the low fuel price scenarios, LNG fuelled ship has no cost advantages in the lifetime perspective.


Among the recent advances and innovations in satellite communications, Non-Geostationary Orbit (NGSO) satellite constellations are gaining popularity as a viable option for providing widespread broadband internet access and backhauling services. However, a more complex ground segment with multiple ground stations is necessary due to these satellites' high speeds and low altitudes. The complete dimensioning of the ground segment, including gateway optimal placement and the number of ground access points, remains a relevant open challenge. In this article, we provide an overview of the key factors that shall be considered for NGSO gateway station geographical planning. Subsequently, we propose a ground segment dimensioning approach that combines several criteria, such as rain attenuation, elevation angle, visibility, geographical constraints, and user traffic demands. The operational concept is first discussed, followed by a methodology that combines all these constraints into a single map-grid to select the best position for each gateway. Furthermore, a case study is presented, which demonstrates the performance of the proposed methodology, for one example constellation. Finally, we highlight relevant open challenges and key research directions in this area.


The importance of the role of management accounting (MA) in measuring emerging non‐financial performance (NFP) is increasing, especially in the service sector. However, there are a number of studies concerning NFP measures, but comparatively little is known about non‐financial MA measures in services and almost nothing in banks/financial institutions (BFI). Taking into consideration the need for studying MA practices in measuring emerging NFP in the service industry, an attempt has been made in this paper to investigate the practice of MA in NFP measurement in Finnish BFI. Several factors have been identified, in the context of "New Institutional Sociology" theory that influence NFP measures, of which economic impact is the most influential, followed, subsequently by coercive, normative and mimetic pressures. Accordingly, the empirical findings of this research are evaluated, and consequently, it has been used to modify the theory for further research that fits with the dynamic nature of NFP in the financial industry.


Skeletal myofibers exhibit remarkable diversity and plasticity in contractile and metabolic functions and play a key role in controlling systemic metabolism. Previous studies of muscle fiber-type switching have centered on the specification of slow-twitch myofibers. However, mechanisms that drive fast-twitch myofibers formation remain unclear. Here, we showed that BRD4, an epigenetic reader enriched in fast myofibers, plays a critical role in controlling fast-twitch myofiber identity as well as systemic glucose homeostasis. BRD4 levels are associated with fast-twitch myofiber gene expression in human muscle. Skeletal muscle-specific ablation of BRD4 in mice (Brd4f/fHSA-Cre, BRD4 mKO) resulted in downregulation of the fast-twitch myofiber gene program, increased number (~100%) of type I myofibers and mitochondrial oxidative capacity. This led to enhanced muscle endurance capacity. In adult mice, acute and inducible BRD4 deletion using a tamoxifen-inducible Cre elicited a similar fast-to-slow fiber type switch in muscle. Mechanically, genome-wide ChIP-seq and mRNA-seq analyses revealed that BRD4 directly binds to and activates transcriptional of fast-twitch myofiber genes through cooperating with MEF2. Furthermore, mice lacking muscle BRD4 were protected against high-fat-diet (HFD)-induced obesity, glucose intolerance and insulin resistance. HFD-fed BRD4 mKO mice had significantly less fat mass (∼50%) compared with HFD-fed WT controls. Histological and biochemical measurements confirmed a pronounced (~60%) decrease in fat deposition in BRD4 mKO livers. Thus, our results uncover a previously unrecognized mechanism underlying the determination of fast-twitch myofiber and provide new therapeutic opportunities for driving muscle fiber-type switch to combat metabolic diseases.

 Z.Zhou: None. L.Liu: None. Z.Xu: None. T.Fu: None. L.Yang: None. M.Yan: None. Z.Gan: None.


Three possible pathways for C-N bond breaking in methylamine have been investigated over clean Mo(100) and nitrogen atom-modified Mo(100) surfaces with a nitrogen coverage of 0.25 monolayer (ML) (N-Mo(100)) firstly, and the C-N bond breaking following the intramolecular hydrogen transfer from the CH3 to NH2 is excluded owing to the high barriers. Then methylamine decomposition starting with C-H, N-H, and C-N scission over the nitrogen atom-modified Mo(100) surface with a nitrogen coverage of 0.5 ML (2N-Mo(100)) has been systematically investigated, and the decomposition network has been mapped out. The thermochemistry and energy barriers for all the elementary steps, starting with C-H, N-H, and C-N scission, and sequential reactions from the resulting intermediates, are presented here. The most likely decomposition path is H3CNH2→ H2CNH2 + H → HCNH2 + H + H → CNH2 + H + H + H → C + NH2 + H + H + H → C + NH3 + H2→ C + NH3(g) + H2(g). For the decomposition reactions involved in the likely decomposition path, there is a linear relationship between the energy of transition state and the energy of final state. For the reverse processes of the dehydrogenation of CH, NH, NH2, it is found that there is a linear relationship between the barrier and the valency of A (A[double bond, length as m-dash]C, N, and NH).


With the rise of competitive online gaming and esports, players' ability to review, reflect upon, and improve their in-game performance has become important. Post-play visualizations are key for such improvements. Despite the increased interest in visualizations of gameplay, research specifically informing the design of player-centric visualizations is currently limited. As with all visualizations, their design should, however, be guided by a thorough understanding of the goals to be achieved and which information is important and why. This paper reports on a mixed-methods study exploring the information demands posed by players on post-play visualizations and the goals they pursue with such visualizations. We focused on three genres that enjoy great popularity within the competitive gaming scene. Our results provide useful guideposts on which data to focus on by offering an overview of the relevance of different in-game metrics across genres. Lastly, we outline high-level implications for the design of post-play visualizations.


Seven canola genotypes selected from early and mid-maturing groups of canola genotypes presently planted in the Western Cape canola production area were grown in 3 litre plastic bags filled with a mixture of sand and compost at ratio of 1:1 and irrigated with fully balanced nutrient solution at EC=2.0 in two glasshouses at night/day temperature regimes of 10/15˚C and 15/20˚C. Plant heights were measured at 14 days interval from 28 to 84 days after planting (DAP). Plants were sampled for leaf area (LA) and above ground dry mass (DM) at budding, flowering and seed physiological maturity stages. Plant growth rates (PGR) from planting to budding, from budding to flowering and from flowering to physiological maturity growth stages were calculated. Relative growth rates (RGR) and net assimilation rates (NAR) from budding to flowering and from flowering to physiological maturity stages were also calculated. Days after planting, GDD and PTU at budding, flowering and physiological maturity were correlated with leaf area, dry mass, number of pods plant-1   and pod dry mass plant-1 at budding, flowering and physiological maturity stages to determine whether there were relationships between the variables. The study showed that by increasing night/day temperature from 10/15˚C to 15/20˚C plant height, number of leaves plant-1 at budding stage, leaf area at budding , plant growth rate (PGR) from planting to budding stage and relative growth rate (RGR) from budding to flowering stage were increased. However, PGR from budding to physiological maturity, RGR from flowering to physiological maturity, net assimilation rate (NAR) from budding to flowering stage, leaf area at flowering and physiological maturity stages, as well as  number of flower stems, number of pods  plant-1, above ground total dry mass at flowering and physiological maturity  stages were  decreased. Pod dry mass at physiological maturity decreased by 22.24% to 40.35% for different genotypes which clearly demonstrated the variations in sensitivity of canola genotypes to increasing night/day temperatures and also indicates that canola crop can be genetically improved for heat tolerance.


This article discusses possible dialogues between medical history and the history of concepts, suggesting that a "socio-conceptual-moral" history of medicine offers insightful elements for the historical analysis of conceptual change. Drawing mainly from Reinhart Koselleck's Begriffsgeschichte and Ludwik Fleck's theory of knowledge, I focus on three points of the "socio-conceptual-moral" perspective: the approach to medical statements as part of a semantic field, the interaction between a formulated concept and its practice, and negotiations about the meanings of medical concepts between different social arenas. I take the history of cancer prevention in Brazil as a case study to discuss these three aspects and emphasize the situated character of conceptual change. The article analyzes the period between the 1960s and the 1990s when substantial changes in the conceptual framework of cancer prevention confronted continuities in public health and medicine practices, policies, and institutions.


Abstract Purpose: The purpose of this paper is to show the trends in employing LIS graduates in Slovenia in the period from 2000 to 2012. Methodology/Approach: We collected, presented and analysed the publicly available data on the number and fluctuation of LIS graduates registered as job seekers at the national employment service. The paper also presents the fluctuation in the number of related job advertisements, and the number of employees in Slovenian libraries. Results: According to the Employment Service of Slovenia, the number of job seekers has been rising but it does not exceed the number of tendered study positions or the number of ads for job vacancies. Until 2012, only a third of job seekers were first time job seekers under 26 years of age. In recent years, the ratio of advertisements for the fixed-term employment has been increasing compared to those for the permanent employment. The majority of the ads offer employment in the central region of Slovenia, usually in the capital city which is the economic, political and university centre where the majority of all the libraries are concentrated. In addition, there is an increase in the number of ads during the summer months. The number of employees in Slovenian libraries has been rising year by year, in parallel to the increased proportion of library and information science graduates. Limitations of the research: We cannot make any conclusions about graduates of the Bologna study programmes, on one hand the first degree graduates are not very numerous on the job market and on the other hand many of them enrol the second degree Bologna study programme. Originality/practical implications of the research: For the first time in Slovenia, the research provides quantitative data on the number of the unemployed LIS graduates and on the number of job vacancy ads for LIS graduates.


Summary.  With 1.3 billion people, China has the largest population in the world, and therefore has the largest population of persons with haemophilia (PWH). As there is no national registry for haemophilia, it is difficult to ascertain how many PWH have actually been diagnosed. Between January 1983 and June 2002, 1312 patients with coagulation disorders were referred to our hospital, and 1190 patients were evaluable. Among them, 1069 (89.8%) patients had haemophilia, 68 had vWD, 20 had factor XI deficiency, 10 had acquired factor VIII inhibitor and 23 had other coagulation disorders. Of the 1069 PWH, 14.7% were unclassified, 38.4% severe, 35.7% moderate and 11.1% mild. If the unclassified cases were excluded, 45.1% were severe, 41.9% moderate and 13.0% mild. Twenty‐nine of the 68 vWD patients had vWF:Ag <5%, and subcategorized as type 3 vWD. Because vWF multimer analysis was not performed in our centre, the remaining vWD patients were not subdivided.


OpenACC is a directive-based programming model designed to allow easy access to emerging advanced architecture systems for existing production codes based on Fortran, C and C++. It also provides an approach to coding contemporary technologies without the need to learn complex vendor-specific languages, or understand the hardware at the deepest level. Portability and performance are the key features of this programming model, which are essential to productivity in real scientific applications. OpenACC support is provided by a number of vendors and is defined by an open standard. However the standard is relatively new, and the implementations are relatively immature. This paper experimentally evaluates the currently available compilers by assessing two approaches to the OpenACC programming model: the "parallel" and "kernels" constructs. The implementation of both of these construct is compared, for each vendor, showing performance differences of up to 84%. Additionally, we observe performance differences of up to 13% between the best vendor implementations. OpenACC features which appear to cause performance issues in certain compilers are identified and linked to differing default vector length clauses between vendors. These studies are carried out over a range of hardware including GPU, APU, Xeon and Xeon Phi based architectures. Finally, OpenACC performance, and productivity, are compared against the alternative native programming approaches on each targeted platform, including CUDA, OpenCL, OpenMP 4.0 and Intel Offload, in addition to MPI and OpenMP.


Concurrent with the political and diplomatic developments just described, and exercising a significant influence upon them, there occurred a vast overseas expansion of Western Civilization. Although the Crusades were the first phase of this expansion, not until the early modern period did European energies burst forth with sufficient vigor that their impact became worldwide. In the intervening centuries such things as the growth of commercial capitalism, the rise of the strong national state, and the intellectual upsurge associated with the Renaissance prepared Europeans for the mighty task of discovering, exploring, and colonizing areas in all parts of the globe. [excerpt]


An impedance measurement system for an atmospheric microwave-induced plasma is proposed using equivalent transmission line theory and a de-embedding process of an input impedance. An argon plasma was generated by using a microwave-induced discharge. The generator consists of a 2.45 GHz solid state power oscillator (SSPO), a circulator, a directional coupler, a three-stub tuner, a gas flow meter, and a plasma jet. The microwave source power was varied from 10 to 25 W, and the argon gas flux was varied from 1 to 5 L/min at atmospheric pressure. The experimental results for the microwave-induced plasma show the impedance behaviors of the resistance and the inductive reactance. The near unity voltage standing wave ratio (VSWR) from the experiment results ensures that the proposed measurement system is valid.


Lumbar CSF concentrations of homovanillic acid (HVA) and 5-hydroxyindole-acetic acid (5HIAA) have been determined in ten patients suffering from chronic brain post-traumatic syndromes, at various length of time after the brain trauma. Lower concentrations of HVA (mean 21 +/- 14 mug/ml) compared to controls (mean 46 +/- 10 mug/ml) was observed in 7 cases; 5HIAA levels were within normal values. The 5HIAA/HVA ratio (1.59 +/- 0.66) was significantly higher (p less than 0.001) than the one recorded in controls (0.66 +/- 0.10). Monitoring of lumbar HVA and 5HIAA over time, before, during and after L-dopa treatment, revealed interesting correlations between modification of clinical picture and the levels of monoamines acid metabolites. The data indicate a profound alteration of brain monoamines in chronic syndromes following a severe head injury and suggest that measurements of lumbar HVA and 5HIAA in these patients may be of euristic and diagnostic value.


—The paper presents the potential for RES in Romania and the results of the Romanian national research project "Romania contribution to the European targets regarding the development of renewable energy sources - PROMES". The objective of the project is the development of energy generation from renewable energy sources (RES) in Romania by drawing up scenarios and prognosis harmonized with national and European targets, RES development effects modeling (environmental, economic, social etc.), research of the impact of the penetration of RES into the main , implementation of an advanced software system tool for RES information recording and communication , experimental research based on demonstrative applications . The expected results are briefly presented, as well as the social, economic and environmental impact.


ABSTRACT

Lailanjani, Nisfah, 2017. "Analisis Kontrastif Proses Pembentukan Kata Ragam Bahasa Slang Jepang dan Indonesia". Thesis, Department of Japanese Literature Faculty of Humanities Diponegoro University. Supervisor Elizabeth Ika Hesti A.N.R, S.Hum., M.Hum.

Slang is a special and confidential social variation. It changes continuously because the confidential of the language. It is used by a certain group or people so no one can understand except the member of the group. This kind of social variation is commonly used by youth. That's why many elders doesn't know this language. Slang's phenomenan occurred on many languages, including Japanese and Indonesian. The writer found that there are similarities between Japanese and Indonesian slang. It occurred especially on word formation and meaning change.

This thesis has two purposes. First, is to analyze Japanese and Indonesian slang word formation and meaning change. Second, is to know the differences and the similarities between Japanese and Indonesian slang especially on word formation and meaning change.

To gain the purposes, this thesis used contrastive analysis. Contrastive analysis is a contrast between the two languages to get the differences. From the differences, the writer could find the similarities.

The results of this thesis are, Japanese slang has six kind of word formation. There are clipping, composition, affix, acronym and initial, blending and reduplication. Indonesian slang has three kind of word formation. There are acronym, absorption, and affix. For the meaning change, both Japanese and Indonesian slang have similarities in widening of meaning. The differences between word formation of Japanese and Indonesian slang are (1) Japanese slang clipped two words then combine it, but Indonesian slang just clipped one word. (2) Composition, prefix, suffix, blending, and reduplication only found in Japanese slang. (3) Indonesian acronym is more diverse. (4) Japanese slang absorption words pronunciation is little bit different. The similarities between Japanese and Indonesian slang are both have same word formation. They are clipping, affix, acronym, absorption, and using another element in the slang word.

Keywords: Word formation, Widening of meaning, Japanese slang, Indonesian slang, Contrastive analysis


2019 was the year for sciences in Colombia has been a milestone after the official structuring of Science, Technology and Innovation's Ministry (MinCiencias), allowing scaling decisions of research, development and innovation to executive power and whose main challenges will be in the coming years, continue process of building a knowledge-based country, technology, scientific capabilities and improving of academy, industry and government linkage; this challenges requires a collective construction of main science authority and different higher education organizations, groups, research and technological development centers, but especially the participation of researchers in all knowledge areas.
In addition to the creation of the Ministry of Science, Technology and Innovation, the work leaded by "Mision de Sabios 2019", have defined the roadmap for scientific development in Colombia since eight thematic axes constituted in: 1. Biotechnology, bioeconomy and environment, 2. Basic and space sciences, 3. Life and health sciences, 4. Social sciences, development and equity, 5. Sustainable energy, 6. Creative and cultural industries, 7. Oceans and hydrobiological resources and 8 Converging technologies, nano, info and cogno industries 4.0; strategic knowledge areas which guide formulations and decisions on different activities that promote high level formation and commitment to scientific research.
 The journal "Liderazgo Estrategico", attached to School of Business of Universidad Simon Bolivar, reaffirms its work and commitment with research formation and the promotion of science, technology and innovation on new Colombian researchers, positioning itself as a part of knowledge's social appropriation on administrative, economic and accounting sciences, consolidating in its ninth volume with new publications result of the articulated work of professors and students, as well as the critical analysis and argumentation of the main argues on the academic field of the different disciplines which are linked to business and management area.
Transcendental challenges for scientific activity are glimpsed at the doors of a 2020 year, not only in Colombia and the Latin American region, too it's consolidating global perspectives that urge researchers on the continuous construction of a knowledge-based society, an intelligent and autonomous industry is strengthened based on the so-called fourth industrial revolution promoting efficiency and productivity, innovation and technology are advancing at rates that promote the transformation of paradigms in society and the first five years of the global declaration of the Sustainable Development Goals (SDG) are fulfilled. How much progress has been made in the consolidation of global goals that will contribute to the construction of a just, equitable and sustainable society ?; from the School of Business and all its instances, scientific research will continue to be promoted as part of its core activity on the construction of knowledge for its different actors, because according to MinCiencias (2019) "#ElConocimientoNosHaceGrandes".


In 2009–2011 field trials were completed at the Experimental Station of Aleksandras Stulginskis University. The aim of the trial was to establish the effect of additional leaf spray fertilization with sollutions of the microelement fertilizers ARVI and biological free amino acid preparation Terra Sorb Foliar on spring rape (Brassica napus L. oleifera annua Metzg.) seed yield and quality indices.
 SW 'Landmark' spring rape was under the trial in the experiment. Before the trial, the field was fertilized with complex fertilizers NPK 16:16:16 250 kg ha–1 and ammonium saltpetre (N34) 150 kg ha–1 (basal fertilisation – control). Spring rape was sown in the third decade of April. The seed norm was 7 kg ha–1. At the bud stage of the spring rape (stage 53–54 according to BBCH scale), the trial plots were leaf sprayed with ARVI of the microfertilizer solution (6 l ha–1), solution of the preparation Terra Sorb Foliar (2 l ha–1), and the mixture of the ARVI microfertilizers + Terra Sorb Foliar solution. Other agrotechnical applications were carried out according to the spring rape growing technologies applied at the experimental station. Rape seeds were harvested by a combine harvester and samples for the chemical analyses were taken. Trial results were estimated by means of the dispersive analysis, employing the computer program ANOVA.
 The trial results revealed that the additional leaf spray fertilization with the ARVI microfertilizers at the bud stage resulted in the statistically significant increase in the spring rape yield by 0.08 t ha–1 or 3.5%. The application of the Terra Sorb Foliar solution resulted in the statistically significant increase of the seed yield by 0.09 t ha–1 or 4.0%. In comparison to the control, leaf spray fertilization of the spring rape with the ARVI micro + preparation Terra Sorb Foliar solution mixture resulted in the significantly higher 0.11 t ha–1 or 4.9% higher seed yield.
 The additional leaf spray fertilization contributed to higher accumulation of fats in the rape seeds. The leaf spray fertilization of the rape with ARVI microfertilizers, Terra Sorb Foliar, and ARVI micro + Terra Sorb Foliar solution mixture resulted in the significant increase in the fats accumulated in the rape seeds by 0.76%, 0.40%, and 1.23%, respectively. The effect of the Terra Sorb Foliar contributed to the reduction in glycosinolades by 0.71–0.81  μmol  g–1, and increase in erucic acid by 0.17–0.28%. In comparison to the control, the additional leaf spray fertilization with the ARVI microfertilizers resulted in 0.26% higher amount of the erucic acid.


The objective of this work is to discuss the concept of degree of technological incorporation (GIT), to propose a measure for the same and to show the applicability of the indicator by means of a research. The relevance of the research is in the proposition of an objective method of measuring the incorporation of technology of the companies. The proposed indicator is based on the added value that represents the wealth created for an entity in certain period of time. The research is accomplished with base in extracted secondary data of the edition of Melhores & Maiores of 2009. The universe consists of the constant companies of the Melhores & Maiores, list of 500 in sales. The sample limited to the 78 companies with referring available data: the wealth created, number of employees and wages and charges. The results show that: it is observed, in the companies, the participation of the wages and profits in relation to the added value, in agreement with the proposed model; there is a positive association, significant at the level of significance 0,05, between GIT of the company and the wage I pay to the worker; there is a positive association, significant at the level of significance of 0,01, between GIT of the company and its added value; there is a positive association, significant at the level of significance of 0,05, between GIT of the company and the volume of the profits. It can be concluded that the model was shown appropriate to show some implications of the incorporation of the technological innovation.


The first workshop on Inference in Computational Semantics (ICoS-1) was held at the Institute for Logic, Language and Computation of the University of Amsterdam, on August 15, 1999. It was aimed at bringing together researchers from scientific disciplines to discuss approaches and applications of inference in natural language semantics, ranging from theoretical to implementational issues. In particular, ICoS-1 featured three invited presentations, six contributed talks, and six system demonstrations showing how inference tools are used in natural language applications. The variety of the program was also mirrored by the spectrum of contributing authors, which included researchers from Computational Linguistics, Artificial Intelligence, Computer Science, and Logic. This special issue is derived from ICoS-1. In it we bring together nearly all of the papers presented at the workshop, as well as short descriptions of the systems that were demonstrated at ICoS-1. Before giving a brief description of the contributions, we discuss some generalities.


The aim of this project is to design a next generation wildlife animal protection and monitoring the animals while crossing the railroads and modernizing existing features and thus try to overcome the drawbacks. There is a long list of features implemented in this paper. This paper helps to prevent the elephant death from train accidents. Each and every train has a receiver which can debug the implanted tag and thereby stop the train when the elephants near a train section. Also this paper initiates a effort to tag all wildlife so that when wild animals like cheetah or leopard enters into a residential area is intimated to the forest rangers by transceiver units placed at potential places where wild animals can enter the human zone.


Abstract 1521 The treatment for acute myeloid leukemia (AML) has not changed dramatically for the last 20 years. Anti-CD33 monoclonal antibody therapy, the most prominent of which is gemtuzumab ozogamicin (GO), has been used over the last decade, in order to improve the results of patients with AML. It has been studied in a variety of contexts; at induction, consolidation and as re-induction after disease relapse. Several randomized controlled trials have evaluated the addition of anti-CD33 to chemotherapy as compared to chemotherapy alone for the treatment of AML. Systematic review and meta-analysis of randomized controlled trials comparing addition of anti-CD33 to chemotherapy with chemotherapy alone in patients with AML, for either induction or post-remission therapy. Patients under 18 years old or those with acute promyelocytic leukemia were excluded. The Cochrane Library, MEDLINE, conference proceedings and references were searched until July 2012. Two reviewers appraised the quality of trials and extracted data. Outcomes assessed were: all-cause mortality at 30 days, all-cause mortality at the end of follow up, complete response and relapse rate. Relative risks (RR) were estimated and pooled. Our search yielded 11 included trials, five of them published as abstracts, including 5239 patients. Most trials assessed GO and two trials assessed lintuzumab as the anti-CD33 agent. Dose and schedule differed between trials. Eight trials examined the effect of anti-CD33 in the induction setting: six assessed the addition of anti-CD33 to intensive induction (daunorubicin and cytarabine based) and two used low dose cytarabine in elderly patients. Three trials examined the addition of anti-CD33 in the post remission setting (one as consolidation, one as maintenance and one after relapse). When analyzing the addition of anti-CD33 in all settings together, there was no difference in all-cause mortality at 30 days or at the end of follow up between chemotherapy with anti-CD33 and chemotherapy alone (RR 1.15 [95% CI, 0.96–1.37, 7 trials], RR 0.96 [95% CI, 0.92–1.00, 8 trials] respectively). In the subgroup of favorable and intermediate risk AML, the addition of anti-CD33 had no effect on all-cause mortality, RR 0.94 (95% CI, 0.87–1.02, 3 trials)], however when analyzing the subgroup of favorable risk patients only, mortality was significantly reduced with the use of anti-CD33 (RR 0.60, 95% CI, 0.42–0.85, 2 trials). Treatment with anti-CD33 had no effect on complete remission rate, RR 1.05 (95% CI 0.96–1.14, 7 trials). Yet, it significantly reduced relapse rate, RR 0.90 (95% CI 0.84–0.96, 4 trials). There was not enough data to evaluate the incidence of veno-occlusive disease. In conclusion, the addition of anti-CD33 to chemotherapy significantly decreased relapse rate, with no effect on all cause mortality. Yet, in the favorable risk subgroup, the use of anti-CD33 significantly reduced mortality. Further research is needed to confirm the beneficial effect in the favorable risk AML patients. Disclosures: No relevant conflicts of interest to declare.


Short-latency auditory responses were derived by cross correlation of pseudorandom white noise with averaged scalp potentials in guinea pigs. The cross-correlation functions were characterized by distinct cochlear microphonic and neural components, as distinguished by susceptibility to hypothermia and masking noise. This technique detects only linear, frequency-following responses of the auditory system, and demonstrated neural frequency following up to 3-4 kHz; thresholds were about 30-40 dB spectrum level. While conventional auditory brain stem responses reflect onset neural activity and are most responsive to high-frequency stimuli, cross-correlation responses reflect frequency-following activity, primarily to low frequencies, and thus may represent a complementary method of electrophysiologic assessment of the auditory system. Data are very rapidly acquired, and estimation of responses of limited areas of the cochlea may be possible by off-line digital filtering of cross-correlation functions obtained with broadband noise stimuli.


This paper models the fertility decision of individuals who differ in their wage rate and their intensity of preferences for rearing children, and whose utility of having a child out of wedlock depends on the level of "social approval" associated with doing so. This social approval in turn is a function of the fraction of individuals in previous generations that chose to have children out of wedlock. The model is a straightforward extension of the typical rational choice model that motivates much of the empirical literature—a literature that has cast doubt on a strong link between AFDC and illegitimacy. However, the model introduces elements from epidemic models that many have in mind when arguing for such a link. As a result, the predictions of this extended model are consistent with empirical findings while at the same time linking the rise in illegitimacy solely to government welfare programs. Specifically, a program similar to AFDC is introduced into an economy with low illegitimacy rates, and a transition path to a new steady state is calculated. Along the transition path, observed cases of illegitimacy are rising among both the poor and nonpoor despite the fact that AFDC payments are held constant or even falling. The simultaneous trends of declining real welfare benefits and rising illegitimacy over the past two and a half decades are therefore not inconsistent with the view that illegitimacy might be caused primarily by government welfare policies. Although this paper certainly does not claim to prove such a link, it does suggest that current empirical approaches have been focused too much on an artificially narrow model and have thus given rise to results that can be differently interpreted in the context of a more natural model. At the same time, the model also suggests that welfare reform aimed at reducing the incentives for poor women to have out‐of‐wedlock births may not be as effective as policy makers who believe in a causal link between AFDC and illegitimacy might suspect.


The analysis of statistic data from real-time driving cycle of hybrid electric vehicle shows relationships that help to optimize control strategy. This paper presents a remote self-learning platform based on general packer radio service (GPRS) for control strategy optimization to hybrid electric vehicle. The platform adopts an in-vehicle device to acquire real-time driving data through CAN bus and communicate wirelessly with central server by GPRS network and INTERNET. A fast clustering method is introduced to classify real-time driving data as different driving cycle. According to driving cycle, online statistical analysis is implemented in central server to obtain energy consumption result, and the optimized control strategy is updated by in-vehicle device. During the process of update to control strategy, the wireless communication quality is a vital factor for completeness of data. A Model-based control algorithm to solve wireless network congestion problem is realized depending on the characteristics of the communication quality. The test result shows that the communication process can be improved greatly and the communication quality is increased 30% at least by this algorithm. The transmission load would be reduced automatically in order to make the communication be normal as soon as possible when the network is under congestion.The study shows that the remote self-learning platform is effective to define and characterize driving cycle of hybrid electric vehicle. In the sample application, remote self-learning platform plays an importance role in optimizing the control and energy management strategy of hybrid electric vehicle.


BACKGROUND
Arteriovenous Fistula (AVF) surveillance is required to detect early dysfunction (thrombosis, stenosis) and its timely correction prolongs access-patency. Clinical examination (CE) and doppler have been used as screening/surveillance of AVF, for early detection of AVF dysfunction. Since there was inadequate evidence for KDOQI to make recommendations on AVF surveillance and on secondary failure rate. We compared CE, doppler and fistulogram as surveillance modalities in detecting a secondary failure in matured AVF.

METHODOLOGY
This prospective-observational, single-center study, was done between December 2019-April 2021. CKD stage 5 patients on dialysis/Not-on-dialysis with matured AVF were included at third month. CE, doppler (blood flow, vein diameter, depth), and fistulogram were done at third and sixth month. Secondary failure was assessed at sixth month classifying AVF to patent/functional and failed group. Diagnostic tests were performed by comparing three methods considering fistulogram as gold-standard. Residual urine output is also monitored to look for any contrast induced residual renal function loss.

RESULTS
Of total 407 created AVF, 98 (24%) had primary failure. Twenty-five (6%) had surgical complications including unsuccessful AVF and aneurysm/rupture, 156 lost follow-up at third month, 104 consented patients were enrolled, 16 lost to follow-up subsequently, and 88 patients' data were analyzed at the end. At the sixth month, 76(86.4%) had patent AVF, 8 (9.1%) had secondary failure (Thrombosis-4, Central Venous Stenosis-4), and 4 (4.1%) patients expired. Considering fistulogram as a diagnostic standard, CE showed 87.5% sensitivity, and 93.4% specificity (cohen's kappa value of 0.66). Doppler had sensitivity and specificity of 87% and 96% respectively (cohen's kappa value of 0.75), Combination of clinical examination with doppler showed sensitivity and specificity of 100% and 89% respectively.

CONCLUSION
Although the secondary AVF failure rate is less than the primary, CE is an important and valuable tool in the diagnosis and surveillance of AVF in detecting its dysfunction. Moreover, CE with doppler can be used as a surveillance protocol that can detect early AVF dysfunction at par with Fistulogram.


The established in vitro thyroid function tests using serum, which depend upon the separation of free from bound exogenous 1311_Triiodothyronine (131I-T3)by an absorbant (Hamolsky et al, 1957; Godden and Garnett, 1964), are both time consuming and are subject to technological difficulties. A reliable screening service using these tests requires a great deal of technical skill and time. The technique described (Pollard et al, 1965; Garnett et al, 1965) utilises the AutoAnalyzer principle of continuous flow dialysis to separate free from bound 1311_T3' Variations in radio-activity of the dialysate, which are related to the degree of binding of exogenous 1311_T3 by serum, are monitored by a continuous flow counting arrangement.


Currently, most of the power-level control methods of nuclear reactors are given based upon the scheme of inducing reactivity directly via control rods. However, the reactivity can also be injected indirectly via the negative temperature feedback effect. Motivated by this, a cascaded power-level control of high temperature gas-cooled reactor (HTGR) is proposed by only regulating primary helium flowrate, which can be able to provide globally asymptotical closed-loop stability. This new HTGR power-level control is composed by a helium temperature controller and a neutron flux controller. The former controller, which is located in the inner loop, regulates the primary helium flowrate according to the setpoint of helium temperature. While, the latter one in the outer loop revises the setpoint of helium temperature so as to regulate neutron flux. Numerical simulation results verify the theoretical result while showing the satisfactory performance as well as the influence from the controller parameters.


The chemical composition of 71 essential-oil samples isolated from the leaves of Chromolaena odorata harvested in eight Ivoirian sites (Toumodi, Dougba, Yamoussoukro, Zambakro, Toumbokro, Attiegbakro, Tiebissou and Tie-N'Diekro) was investigated by GC-FID, including the determination of retention indices (RIs), and by 13C-NMR analyses. In total, 31 components accounting for 55.5 - 90.2% of the oil composition were identified. The content of the main components varied from sample to sample namely geijerene (3.2 - 26.4%), germacrene D (1 - 28.5%), (E)-β-caryophyllene (8.1 - 18.3%), α-pinene (0.2 - 8.5%) and δ-cadinene (1.4 - 9.5%). Other constituents present at appreciable contents were β-pinene (0 - 8.3%), α-copaene (2.2 - 8.0%), α-humulene (2.1 - 4.7%). The 71 samples were submitted to factorial discriminant analysis using 40 variables (4 physicochemical constants yield 31 chemical constituents and 4 geographical coordinates), which allowed the distinction of eight groups within the oil samples labeled according to the eight sites of harvest in respect of chemical components.

 Key words: Chromolaena odorata, Asteraceae, essential oil composition, factorial discriminant analysis, physico-chemical constants, geijerene, germacrene D, (E)-β-caryophyllene).


Internal tandem duplication within FLT3 (FLT3-ITD) is one of the most frequent mutations in acute myeloid leukemia (AML) and correlates with poor prognosis. While FLT3 receptor tyrosine kinase is activated at the plasma membrane to transduce PI3K/AKT and RAS/MAPK signaling, FLT3-ITD resides in the endoplasmic reticulum (ER) and triggers constitutive STAT5 phosphorylation. Mechanisms underlying this aberrant FLT3-ITD subcellular localization or its impact on leukemogenesis remain poorly established. Here we discover that FLT3-ITD is S-palmitoylated by the ZDHHC6 palmitoyl acyltransferase. Disruption of palmitoylation redirected FLT3-ITD to the plasma membrane and rewired its downstream signaling by activating AKT and ERK pathways in addition to STAT5. Consequently, abrogation of palmitoylation increased FLT3-ITD-mediated leukemic progression in xenotransplanted mouse models. We further demonstrate that FLT3 proteins were palmitoylated in primary human AML cells. ZDHHC6-mediated palmitoylation restrained FLT3-ITD surface expression, signaling and colonogenic growth of primary FLT3-ITD+ AMLs. More importantly, pharmacological inhibition of FLT3-ITD depalmitoylation synergized with FDA-approved FLT3 kinase inhibitor gilteritinib in abrogating the growth of primary FLT3-ITD+ AML cells. These findings provide novel insights into lipid-dependent compartmentalization of FLT3-ITD signaling in AML and suggest targeting depalmitoylation as a new therapeutic strategy to treat FLT3-ITD+ leukemias.


In this paper finite-dimensional singular linear
discrete-time-invariant systems in the form Ex(k +
1) = Ax(k) + Bu(k), y(k) = Cx(k) where E;A 2
M = Mn(C), B 2 Mn£m(C), C 2 Mp£n(C), describing
convolutional codes are considered and the notion
of output observability is analyzed.


Newsmaker InterviewAmid mounting attacks on the Intergovernmental Panel on Climate Change, a small number of its volunteer leadership has tried to respond to the horde of bloggers and reporters as well as explain themselves to colleagues. Prominent among them has been ecologist Christopher Field of the Carnegie Institution for Science. Science excerpts a 5 February phone interview with him.


Abstract In the present study, we computed the thermo-chemical and thermo-physical properties of the 2M1 polytype of muscovite in the 0-10 GPa and 0-900 K ranges, using the hybrid DFT/B3LYP-D* density functional, corrected to take into account dispersive forces, and by using the quasi-harmonic approximation. The bulk modulus KT0 of muscovite, its first derivative K′, and the unit-cell volume at zero pressure V0 at 298.15 K, calculated using a third-order Birch-Murnaghan equation of state, were KT0 = 59.93 GPa, K′ = 7.84, and V0 = 940.6 Å3. Our theoretical data are in good agreement with previous experimental results obtained by X‑ray diffraction. Thermal bulk moduli, KT, thermal expansion coefficients, αT, and heat capacity at different P-T conditions are given, which could be useful in both geophysical and technological applications. The results of this kind of analysis can be used in the study of the thermodynamic properties of solid phases at physical conditions that are difficult to obtain during experimental procedures, especially under controlled high pressures and temperatures.


Paget's disease (PD) is a chronic progressive disease of the bone characterized by abnormal bone resorption and deposition affecting either single bone (monostotic) or many bones (polyostotic) with uncertain etiology. We report a case of isolated mandibular involvement in a 65-year-old female patient, clinically asymptomatic with abnormally increased alkaline phosphatase level (1 368.1 U/l). Although prevalence of PD is common in western countries, but rare in Asian chapter, that too isolated mandibular involvement, considering this fact, we report this case of PD for documentation.


Racialized Sexual Discrimination (RSD), also known as 'sexual racism,' is pervasive within online dating venues. RSD is associated with poor mental health outcomes among young sexual minority Black men (YSMBM), and there is limited research on factors that may mitigate this association. Ethnic identity has been identified as a potential protective factor for racial/ethnic minorities who encounter racialized stressors, though some evidence suggests that ethnic identity may also intensify the negative effects of racial discrimination. Using data from a cross-sectional web-survey of YSMBM (n = 690), a series of linear regression models were estimated to examine the moderating effect of ethnic identity search and ethnic identity commitment on the relationship between RSD and depressive symptoms/feeling of self-worth. Results indicated that having moderate-to-high scores on commitment attenuated the association between being physically objectified by White men and higher depressive symptoms. However, having high scores on commitment intensified the association between being rejected by Black men and lower feelings of self-worth. Stronger identity commitment may be protective against objectification from White men, though it may also exacerbate negative outcomes related to in-group discrimination. These findings may have important implications for the development of individual and group-level interventions addressing ethnic identity among YSMBM.


Small cell lung carcinoma (SCLC) frequently metastasizes early in the course of the disease. P-selectin (P-sel), a cell adhesion molecule expressed on activated platelets and endothelial cells (EC), has previously been demonstrated to mediate binding of platelets to SCLC. We hypothesized that P-sel facilitates attachment of SCLC to EC, acting as an important factor in SCLC metastasis. To test this hypothesis, attachment of H82 cells (SCLC cell line) to EC was quantified. Attachment of H82 cells to 12-O-tetradecanoylphorbol-13-acetate (TPA)-activated EC was increased compared with control EC. Increased attachment of H82 cells to EC was apparent after 10 min of TPA activation, reached a peak after 30 min, and returned to baseline after 120 min of exposure. The TPA-induced increase in H82 cell attachment to EC was inhibited by addition of anti-P-sel antibodies but not by addition of anti-E-selectin antibodies. The TPA-induced increase in H82 cell attachment was likely mediated by activation of EC protein kinase C (PKC). Pretreatment of the EC with PKC inhibitors effectively blocked the TPA-mediated increase in H82 cell attachment. In addition, prolonged exposure of EC to TPA resulted in decreased expression of the PKC-alpha and PKC-epsilon isoforms. These data indicate for the first time that attachment of SCLC to activated EC appears to be mediated by increased expression of P-sel on the EC surface, which may result from activation of specific isoforms of PKC.