Reverse link capacity of a direct-sequence codedivision multiple-access (DS-CDMA) system in a multicell environment has been studied recently, and significant capacity improvements due to the use of beamforming have been observed. However, system performance with beamforming will be affected by several impairments, such as direction of arrival estimation errors, array perturbations, mutual coupling, and signal spatial spreads. In this paper, reverse link performance of CDMA systems with beamforming under these impairments (imperfect beamforming) is investigated. A simplified beamforming model is developed to evaluate the system performance in terms of user capacity, bit-error rates (BER), and outage probabilities. Both signal-to-interference-ratio-based power control and strengthbased power control are considered in this paper. The capacity and BER degradations due to different impairments are shown, and outage probabilities under different power control schemes are examined


A new multi-output forward (MOFC) converter is proposed. It consists of four synchronous switches in secondary side for two outputs. The primary switches control the main output voltage and the synchronous switch in transformer secondary side controls the auxiliary output voltage. The main advantages of the proposed converter are that the secondary switch can achieve the zero voltage switching (ZVS) at entire load conditions and the secondary rectified voltage is a three level waveform, which can reduce the output filter. The operational principle, analysis and design considerations of the proposed converter are presented in this paper. The validity of this study is confirmed by the experimental results from dual outputs (12V-18.3A and 5V-6A) prototype for PC power supply.


The formation of low-mass X-ray binaries containing a rather massive ($M \ga 7 M_{\odot}$) black hole is problematic because in most recent stellar evolutionary calculations the immediate progenitors of these black holes (Wolf-Rayet stars) lose so much mass via their stellar wind that their final masses are well below the observed black hole masses. We discuss the recently proposed solution that these binaries are formed through case C mass transfer (i.e. mass transfer after core helium burning is completed), avoiding a long Wolf-Rayet phase and thus significant mass loss. We show that only some of the currently available models for the evolution of massive stars allow this formation channel. We also investigate the effect of the downward revised Wolf-Rayet mass-loss rate as is suggested by observations, and conclude that in that case Wolf-Rayet stars end their lives with significantly higher masses than previously found and may be able to form a black holes.


The purpose of this symposium is to begin an ICET collective
conversation about the mission and role of faculty development
centers at our own institutions with the intention of fostering
a collaborative research agenda focused on documenting the
3-way impact of such centers: 1.) effectiveness of the center;
2.) effectiveness of teaching; and 3.) enhancement of student
learning. As universities around the world prepare for the
increasing demand for data driven instructional decision-making
coupled with proof of student learning against outcome-based
learning objectives, the role of the faculty development
centers (FDCs) on our campuses becomes more prominent. Many
ICET institutions have such centers under various names with
different structures, missions, and programs. In the 21st
century, higher education faculties are perhaps the most
critical factor in developing educational programs that support
global socioeconomic sustainability. Not only do instructors
have to fight to engage students but their programs must
prepare graduates who can think critically, have the skills of
lifelong learners who can adapt to rapid change, and, at the
same time, be ready for the ever changing workplace, Higher
education institutions face pressure from the consumer, the
workplace, policy makers, and the media to prove that graduates
have acquired the education required for society to maintain or
improve its level of economic security. The recession of 2008
heightened the tensions. (Partnership Toward 21st Century
Skills, 2007; Dolence and Norris, 1995).


Abstract State-to-state accountability has greatly failed to improve compliance with multilateral environmental agreements. As this is also the case in the Convention on Biological Diversity (CBD), this article explores how and with what effect nongovernmental organizations (NGOs) persuade states to fulfill their commitments to conserve biodiversity. The article conceptualizes accountability as learning-enabling dialogue with the potential to influence state behavior through the provision of constructive criticism. The underlying argument is that NGOs can contribute to overcoming implementation challenges by engaging in constructive dialogue with states. The triangulation of interviews with NGOs, CBD documents, and gray literature suggests that NGOs can challenge or even prevent states' inertia by establishing critical but cooperative multilevel partnerships with states to advance implementation. Reconceptualizing accountability as constructive dialogue may contribute to realizing the transformative potential of accountability. However, more evidence is needed to understand the roles of NGOs in fostering learning and the impact of learning on improving implementation, compliance, and environmental outcomes.


We devise a fast algorithm for the gradient of the long-timeaverage statistics of chaotic systems, with cost almost independent of the number of parameters. It runs on one sample orbit; its cost is linear to the unstable dimension. The algorithm is based on two theoretical results in this paper: the adjoint shadowing lemma for the shadowing contribution and the fast adjoint formula for the unstable divergence in the linear response.


Analyses of sex differences in personality have been reported only in particular scales or individual domains. In this study, a psychometric meta-analysis of adult sex differences in self-reported personality was conducted based on each of the "big five" factors. Examination of 76 studies (1,057 separate effect sizes) on 35 personality scales showed that women's scores were significantly higher than men's on measures of Neuroticism and Agreeableness. This finding raises the issue of whether the observed differences are due to differences in self-report or genuine differences in personality. Three tables are included. (Contains eight references.) (Author/SLD) *********************************************************************** * Reproductions supplied by EDRS are the best that can be made * from the original document. ***********************************************************************


THE FOLLOWING is an excerpt from the Abstracts of the Executive Board Meeting of October 2 to 5, 1957, presented at the Business Meeting of the Academy during the Annual Meeting on October 9, 1957. It is published here at the request of the Executive Board.
 The following statement was adopted by the Board to be given to the members at the Annual Meeting by the President, transmitted to advertisers in Pediatrics by the Business Manager of Pediatrics and appear in the official publication of the Academy, Pediatrics:
 The American Academy of Pediatrics recognized the Physicians' Council for Information on Child Health as an independent organization engaged in a program seeking to improve the health of children. The American Academy of Pediatrics has no connection with the Physicians' Council for Information on Child Health. The two organizations are not related in any way. The American Academy of Pediatrics has no control over the Physicians' Council, its directors, executive committee, officers or members. The Academy has no special knowledge of the program, policy or actions of the Physicians' Council, other than is disclosed by the publications of the Physicians' Council. The policy of the American Academy of Pediatrics is to co-operate with any organization interested in the improvement of child health and welfare.


Advances in microelectronics fabrication technology have created new opportunities for system designers to employ embedded DRAM in system-on-chip (SoC) designs. This paper discusses an embedded DRAM architecture and its prototype implementation. The architecture consists of multiple memory banks, each with a row buffer to hold a subset of recently-accessed rows. The memory banks use either contiguous or interleaved addressing, and the row buffer in each bank uses either direct-mapping or full-associativity to map rows from the DRAM array into the buffer. A write bypass feature is also supported for the row buffer. A prototype memory bank implementation has been developed in VHDL for a programmable logic chip using embedded SRAM memory blocks to emulate a DRAM array. A single 256/spl times/256 memory bank uses only 4% of the logic capacity of a Xilinx XCV2000E chip and 10% of the embedded memory. Operational results demonstrate the functionality of the implementation for read and write accesses.


This paper examines how images of unfortunate childhoods are invoked to make sense of psychological problems in adulthood. I use conversation analysis and membership categorization analysis to study a Swedish radio program in which a psychotherapist talks to people about their personal troubles. The findings suggest that, on one hand, the image of an unfortunate childhood was used as an explanatory framework for individuals' problematic experiences. On the other hand, the childhood‐grounded reasoning, applied to individual cases, illustrated the explanatory framework and reaffirmed it as a commonsense way of reasoning about personal troubles.


The present study investigated the osseointegration promoted by functionalised ceramics with peptide Arg-Gly-Asp (RGD) in a rabbit model in vivo. Histomorphometry of the RGD functionalised ceramic implants was conducted by a trained pathologist to quantify the amount of mature and immature ossification at the bone interface, and then compared to titanium alloy implants. The region of interest was the area surrounding the implant. The percentage of ROI covered by osteoid implant contact and mature bone implant contact were assessed. The presence of bone resorption, necrosis, and/or inflammation in the areas around the implant were quantitatively investigated. All 36 rabbits survived the experimental period of 6 and 12 weeks. All implants remained in situ. No necrosis, bone resorption, or inflammation were identified. At 12 weeks follow-up, the overall mean bone implant contact (p = 0.003) and immature osteoid contact (p = 0.03) were improved compared to the mean values evidenced at 6 weeks. At 6 weeks follow-up, the overall osteoid implant contact was greater in the RGD enhanced group compared to the titanium implant (p = 0.01). The other endpoints of interest were similar between the two implants at all follow-up points (p ≥ 0.05). Functionalised ceramics with peptide RGD promoted ossification in vivo. The overall osteoid and bone implant contact improved significantly from 6 to 12 weeks. Finally, RGD enhanced ceramic promoted faster osteoid implant contact in vivo than titanium implants. Overall, the amount of ossification at 12 weeks is comparable with the titanium implants. No necrosis, bone resorption, or inflammation were observed in any sample.


Abstract : Given a sample set X1,...,XN of independent identically distributed real-valued random variables, each with the unknown probability density function f(.), the problem considered is to estimate f from the sample set. The function f is assumed to be in L2(a,b); f is not assumed to be in any parametric family. This paper constructs an adaptive two-pass solution to the problem: in a pre-processing step (the first pass), a preliminary rough estimate of f is obtained by means of a standard orthogonal-series estimator. In the second pass, the preliminary estimate is used to transform the orthogonal series. The new, transformed orthogonal series is then used to obtain the final estimate. The paper establishes consistency of the estimator and derives asymptotic (large sample set) estimates of the bias and variance. It is shown that the adaptive estimator offers reduced bias (better resolution) in comparison to the conventional orthogonal series estimator. Computer simulations are presented which demonstrate the small sample set behavior. A case study of a bimodal density confirms the theoretical conclusions. (Author)


Representatives of the Staphylococcus genus are the most common pathogens found in hospital environments, and they are etiological agents for a large variety of infections. Various virulence factors are responsible for the symptoms and severity of infections caused by Staphylococcus aureus. Among them are staphylococcal enterotoxins (SEs), which cause staphylococcal food poisoning, and toxic shock syndrome toxin-1 (TSST-1). Some reports indicate that TSST-1 and staphylococcal enterotoxins are also produced by coagulase-negative staphylococci (CNS). The present review aimed to discuss general aspects of staphylococcal toxins as well as the epidemiology, genetics and detection of toxins in Staphylococcus aureus and coagulase-negative staphylococci, since these microorganisms are becoming more and more frequent in nosocomial infections.


Peer trainers from across the country, who worked on road crews, in hospitals, in prisons, and in chemical facilities, themselves brought positive safety and health changes to their workplaces. Through advanced instruction, at the International Chemical Workers Union Council (ICWUC) Center for Worker Health and Safety Education (the Center), they not only learned how to be health and safety instructors, but they also became change agents by responding to questions on the shop floor and taking actions to improve safety and health for themselves and for their fellow workers.


A empirical model is established to analyse the daily retrieval of soil moisture from passive microwave remote sensing using convolutional neural networks (CNN). Soil moisture plays an important role in the water cycle. However, with the rapidly increasing of the acquiring technology for remotely sensed data, it's a hard task for remote sensing practitioners to find a fast and convenient model to deal with the massive data. In this paper, the AMSR-E brightness temperatures are used to train CNN for the prediction of the European centre for medium-range weather forecasts (ECMWF) model. Compared with the classical inversion methods, the deep learning-based method is more suitable for global soil moisture retrieval. It is very well supported by graphics processing unit (GPU) acceleration, which can meet the demand of massive data inversion. Once the model trained, a global soil moisture map can be predicted in less than 10 seconds. What's more, the method of soil moisture retrieval based on deep learning can learn the complex texture features from the big remote sensing data. In this experiment, the results demonstrates that the CNN deployed to retrieve global soil moisture can achieve a better performance than the support vector regression (SVR) for soil moisture retrieval.


This article is mainly concerned with the numerical study of the Cauchy problem for the Laplace equation in a bounded annular region. To solve this ill-posed problem, we follow a variational approach based on its reformulation as a boundary control problem, for which the cost function incorporates a penalized term with the input data. The cost function is minimized by a conjugate gradient method in combination with a finite element discretization. In the case where the input data is noisy, some preliminary error estimates, show that the penalization parameter may be chosen like the inverse of the level of noise. Numerical solutions in simple and complex domains show that this methodology produces stable and accurate solutions.© 2017 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq, 2017


: Management business has successfully forced enterprises to rebuild its process and adopt technology that help in integrating all process across different departments, analysis information in real-time, improve decision-making. ERP is a key information system for these purposes. There are many criteria in choice ERPS based on enterprise and application. Hence, there are many consulting firms with huge number of experts and technicians in carrying out analysis, evaluation ERPs and supporting IT-department in enterprises in selecting suitable ERPS. As many systems are semi-similar in features or semi-suitable for specific organization which leads to confusing decision making. Hence, using Multi-criteria decision method (MCDM) is essential. Using decision-making tools doesn't mean missing data or information about what decision is made for. But sometimes more information creates a confusing decision as in this case-study. The case-study covers two main folds; it provides proposed criteria of ERPS adoption and studies their weights, then decision making process that is established by AHP, FAHP and Neutrosophic-AHP. It compares between the results of these approaches and measures the priority/weight effect of adding sub-criteria. This study provides a comparative analysis of AHP, FAHP and Neutrosophic-AHP. This paper contributes in emphasize the accuracy of Neutrosophic set in decision making. It also emphasizes on importance of using multi-criteria (criteria and factors) in designing decision model special in information system that have many factors for one aspect. The paper also contribute in ERPS field by providing criteria that help decision maker board in adopting ERPS cares on enterprise's culture, vision and business processes. a quality decision of detecting criteria for adopting ERP platforms: decision and sub-criteria accuracy with three for AHP case study decision detecting criteria ERP platforms: decision and sub-criteria accuracy three for AHP case study


Hardware implementation of artificial neural networks (ANNs) using conventional binary arithmetic units requires large area and energy, due to the massive multiplication and addition operations in the inference process, limiting their use in edge computing and emerging Internet of Things (IoT) systems. Stochastic computing (SC), where the probability of 1s and 0s in a randomly generated bit-stream is used to represent a decimal number, has been devised as an alternative for compact and low-energy arithmetic hardware, due to its ability to implement basic arithmetic operations using far fewer logic gates than binary operations. To realize SC in hardware, however, tunable true random-number generators (TRNGs) are needed, which cannot be efficiently realized using existing complementary metal-oxide-semiconductor complementary metal-oxide-semiconductor (CMOS) technology. In this letter, we address this challenge by using magnetic tunnel junctions (MTJs) as TRNGs, the stochasticity of which can be tuned by an electric current via spin-transfer torque. We demonstrate the implementation of ANNs with SC units, using stochastic bit-streams experimentally generated by a series of 50 nm perpendicular MTJs. The numerical value (1 to 0 ratio) of the bit-streams is tuned by the current through the MTJs via spin-transfer torque with an ultralow current of <5 µA (= 0.25 MA⋅cm-2). The MTJ-based SC-ANN achieves 95% accuracy for handwritten digit recognition on the MNIST database. MRAM-based SC-ANNs provide a promising solution for ultra-low-power machine learning in edge, mobile, and IoT devices.


Climate change is threatening water security in water-scarce regions across the world, challenging water management policy in terms of how best to adapt. Transformative new approaches have been proposed, but management policies remain largely the same in many instances, and there are claims that good current management practice is well adapted. This paper takes the case of the Murray–Darling Basin, Australia, where management policies are highly sophisticated and have been through a recent transformation in order to critically review how well adapted the basin's management is to climate change. This paper synthesizes published data, recent literature, and water plans in order to evaluate the outcomes of water management policy. It identifies several limitations and inequities that could emerge in the context of climate change and, through synthesis of the broader climate adaptation literature, proposes solutions that can be implemented when basin management is formally reviewed in 2026.


Mucormycosis is a severe fungal infection that occurs mainly in immunocompromised patients. It is characterized by several syndromes with rhino-orbito-cerebral and pulmonary involvement. We report the case of a 49-year-old patient admitted for diabetic ketoacidosis and Influenza B pneumonia nonresponsive to treatment, which was later diagnosed with pulmonary mucormycosis. After correct diagnosis and appropriate treatment with isavuconazole, the patient had a favorable evolution, which reinforces the importance of an accurate diagnosis.


Current muscle pacemaker technology mostly relies on electrical techniques. The electrical method is well understood and established, however, the electricity is difficult to localize and has a risk of interfering with intact cells, tissues, and organisms, affecting their electrophysiology. Light has the potential to be a novel medium in future pacemaker technology. Light is typically minimally invasive and has low interactivity with biological tissues. Depending on the wavelength, this unique property allows its use to access deep inside biological tissues and opens up potential extension of light and photonics technology to a variety of applications in biosciences, such as in vivo manipulation of biological functions. Combined with nonlinear optical technology, only light technology allows location-selective manipulation deep inside tissues with minimum disturbance to the surrounding areas. Other light properties, such as an inherent sterility and the fact that it does not interfere with measurement instruments, makes the technology attractive. In this chapter, we describe light-based techniques that may be used for future muscle pacemaker technology. Recently we presented femtosecond laser pacemaker for heart muscle cells through nonlinear light technology. This chapter describes details of light interaction with cells and in particular muscle cells, including experimental and modeling studies. Besides nonlinear light technology, other light-based techniques for manipulating muscle activities are reviewed. These techniques may not be able to pace muscle activities, but are still worth considering since they can change the beat rate. In the latter part, this chapter also includes indirect light-tissue interactions mediated by implanted pacemaker devices, such as rechargeable battery and transcutaneous telemetry systems for both deliverying power to an implanted pacemaker and also for monitoring pacemaker function. The light-driven and light-mediated implanted devices may in the future play an important role in developing implanted pacemaker technology. Light-based pacemaker technology has just started recently and the interaction effect is partially unclear and needs to be studied more precisely. The light-based technology, however, has significant and perhaps surprising potential for pacemaker technology. In the future, light-based techniques may not only shed light on the future development of pacemaker technology but can also help understandings of basic underlying science in fatal


Theory grounding is suggested as a way to address the unresolved cognitive science issues of systematicity and productivity. Theory grounding involves grounding the theory skills and knowledge of an embodied artificially intelligent (AI) system by developing theory skills and knowledge from the bottom up. It is proposed that theory grounded AI systems should be patterned after the psychological developmental stages that infants and young children go through in acquiring naive theories. Systematicity and productivity are properties of certain representational systems indicating the range of representations the systems can form. Systematicity and productivity are likely outcomes of theory grounded AI systems because systematicity and productivity are theoretical concepts. Theory grounded systems should be well oriented to acquire and develop these theoretical concepts.


One of the basic motivations of the KLOE-2 and WASA-at-COSY experiments is the test of fundamental symmetries and the search for phenomena beyond the Standard Model in the hadronic and leptonic decays of ground-state mesons and in particular in decays of the η meson. At COSY these mesons are produced in collisions of proton or deuteron beam with hydrogen or deuterium pellet target, and at DAΦNE η mesons originate from radiative decays of φ meson or from the fusion of virtual gamma quanta exchanged between colliding electrons and positrons. This contribution includes brief description of experimental techniques used by KLOE-2 and WASA-at-COSY as well as some of physics aspects motivating investigations of production and decays of η mesons.


Complexity management is an increasing challenge for industrial companies. To address this issue, this paper develops a procedure to reduce the complexity of products and processes. This procedure includes five steps: (1) definition of the scope of the products and processes to be included in the analysis, (2) grouping of products into A,B, and C categories, (3) identification and quantification of the most important complexity cost factors, (4) identification of initiatives for the possible reduction of complexity costs and the quantification of possible cost savings, and (5) evaluation and prioritisation of initiatives. To test the usefulness of the suggested procedure, it was applied at a globally leading manufacturer of mechanical consumer products. The case study demonstrated the usefulness of the proposed procedure in (1) supporting the allocation of complexity costs in relation to individual product variants, (2) achieving a better understanding of the cost structure of product assortment and business processes, and (3) providing a basis for generating and evaluating initiatives aimed at reducing the complexity of products and processes. The case study also showed that the use of the procedure can produce considerable financial benefits.


Nowadays, data is everywhere and everyone can access it. This data is characterized by its diversification and heterogeneity. So, as consequence, the challenge is to be able of getting useful information of all that data. The interdisciplinary field of data mining appears as a computational process of extracting information from data and transform it into an understandable structure to be applied. Pattern mining is a subfield inside data mining which tries to extract relevant knowledge in the form of patterns from datasets. The final goal of these patterns is to be useful and to help the decision-making process. Constraints are an identified way of getting more interesting patterns and focusing on the pattern mining algorithms to the expectations of the users but until now their importance is very limited by the expression power of the tools used to define them. Ontologies were identified as a new possibility of representing knowledge in a more interesting way. In this work, we developed a ontology based framework for the sequential pattern mining process, the OntoC4S framework, to introduce domain knowledge specified by the user's input. This framework is able to represent sequential and concurrent events, in order to define constraints over sequential data. The goal of this work is to enable the representation of more expressive constraints when compared with other constraints' representation and to obtain a broader way of embody user knowledge while optimizing the current algorithms. The results show that the framework achieves the proposed goals while keeping the performance of unconstraint algorithms. This work is done within the D2PM project where a framework for guiding the pattern mining process is the goal to be accomplished.


The aim of this study was to examine the relationship between low-density lipoprotein cholesterol (LDL-C) and apolipoprotein (Apo) B levels and the SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery (SYNTAX) score (SS) in patients with stable angina pectoris. We enrolled 594 patients who were suspected to have coronary heart disease (CHD) and who underwent coronary angiography. Patients were divided into 4 groups based on the SS: normal (SS = 0, n = 154), low SS (SS ≤ 22, n = 210), intermediate SS (22 < SS < 32, n = 122), and high SS (SS ≥ 33, n = 63). Positive correlations between lipoprotein (a), LDL-C, ApoB, total cholesterol, and SS were significant (r = 0.132, 0.632, 0.599, and 0.313, respectively; P < .01), whereas high-density lipoprotein cholesterol (HDL-C), ApoA1, and ApoA1/ApoB levels showed a significant negative correlation (r = −0.29, −0.344, and −0.561, respectively; P < .01). Multivariate linear regression analysis revealed that LDL-C, ApoB, ApoA1/ApoB, fibrinogen (Fg), and HDL-C levels had an effect on SS (standardized regression coefficients were 0.41, 0.29, −0.12, 0.08, and −0.09, respectively; P < .05). In conclusion, LDL-C, ApoB, ApoA1/ApoB, Fg, and HDL-C levels affected the SS and were predictors of CHD complexity.


Purpose – This bachelor thesis compares high-speed rail (HSR) transport with air transport. The investigation considers physical fundamentals, energy consumption, environmental impact, infrastructure and investment, market situations, passenger's selection criteria to choose transportation options, and overall economics. --Methodology – The thesis combines an investigation of physical principles with a literature review. --Findings – Steel wheels on steel rails show by far less rolling resistance to support the train's weight than drag due to lift (induced drag) to support the aircraft's weight. This leads to less energy consumption. HSR trains use electricity from an overhead line. Hence, the environ-mental impact of HSR also depends much on how the electricity is produced. Airplanes only need an air traffic control environment to connect airports. In contrast, HSR needs infrastructure to connect stations. The amount of necessary infrastructure depends on the geological conditions. For example, crossing mountains means high investment. Longer passages over water are infeasible for HSR. High-speed rail is superior to air transport when connecting megacities because the trains have higher transport capacity, offer higher service frequencies and mission reliability, shorter total travel time, shorter access time to stations, shorter unproductive waiting time in stations and potentially lower travel costs. HSR is a strong competitor to airline services and has replaced some short range flights. A comparison of HSR in different world regions shows differences in the market situation and in passenger's selection criteria for transportation options. --Research limitations – The potential of high-speed rail was investigated mainly on busy routes with high service frequencies. A comprehensive network comparison between high-speed trains and airplanes was not done and could lead to somewhat different results. --Practical implications – The report tries to contribute arguments to the discussion about alternatives to air travel. --Social implications – With more knowledge people can make an educated choice between transport options, can vote with their feet, and can take a firm position in the public discussion. --Originality/value – A general comparison of HSR and air transport from physical fundamentals to economics seemed to be missing.


Refineries execute a series of interlinked processes, where the product of one unit serves as the input to another process. Potential failures within these processes affect the quality of the end products, operational efficiency, and revenue of the entire refinery. In this context, implementation of a real-time cognitive module, referring to predictive machine learning models, enables the provision of equipment state monitoring services and the generation of decision-making for equipment operations. In this paper, we propose two machine learning models: (1) to forecast the amount of pentane (C5) content in the final product mixture; (2) to identify if C5 content exceeds the specification thresholds for the final product quality. We validate our approach using a use case from a real-world refinery. In addition, we develop a visualization to assess which features are considered most important during feature selection, and later by the machine learning models. Finally, we provide insights on the sensor values in the dataset, which help to identify the operational conditions for using such machine learning models.


This article considers how technologies actively shape the topologies of UK higher education. Using the example of lecture capture systems, we examine the relationship between learning technologies and formations of space and time. Combining theories of sociomateriality and social topology, and concepts of assemblage and relationality, we expose the entanglement of interests that influence university spaces and times. Across 3 months coinciding with the onset of COVID-19 we collected over 500 tweets that discussed lecture capture within UK higher education, leading towards 2 central arguments. First, the topology of the lecture is fluid, and, even while being radically technologised, re-spatialised and disrupted, it persists as a lecture and a central pedagogical feature of university life. Second, lecture capture is a rich site of 'issuefication', and viewing learning technologies as dynamic issues enables a better understanding of how their meaning, function and influence are contingent on shifting and relational assemblages of human and non-human interests. Lecture capture can be pedagogical, commercial and political, thereby resisting deterministic framings of the relationship between technologies and the temporal and spatial arrangements of higher education.


Resonance ionization spectroscopy combined with mass spectrometry (RIMS) has become an important technique for ultratrace environmental analysis, and is particularly well suited for the detection of long-lived radio-toxic isotopes. A variety of experimental approaches have been developed to address the specific requirements posed by individual isotopes, which have widely differing physical, chemical, and environmental properties. In this paper we discuss the principles and recent progress in the development of three different methods that are being used for the analysis of radiotoxic species. These include measurement of actinides using triple-resonance ionization and time-of-flight mass spectrometry, development of a high efficiency laser ionization source primarily used for the detection of technetium isotopes, and collinear fast beam spectroscopy to provide extremely high isotopic selectivity necessary e.g. for the quantitative determination of 89,90Sr in environmental samples.


Background.Clinical studies have shown that the most oncological patients have impaired immunological reactivity. Monitoring of the immune system status of patients with solid tumors includes a subpopulation analysis of immunocompetent cells. It is based on the study of expression of surface antigens and intracellular structures, and an analysis of the functional activity of immunocompetent cells. Today two, three, and even four-color reagents are used for subpopulation analysis of lymphocytes. Fluorescent conjugate with monoclonal antibodies (MAB) of the ICO series and fluorescent dyes Imd-306, Imd-506 (cyanine) and phycoerythrin (a group of phycobiliproteins) was received and characterized in N.N. Blokhin National Medical Research Center of Oncology. These conjugates have proved themselves in one and two-color analysis of subpopulations of peripheral blood lymphocytes by flow cytometry.The purposeof this study is to assess the possibility of sharing several immunofluorescent probes (IFP) on the basis of different Mab series of ICO and dyes FITC, Imd306, Imd506 and PE for three-color analysis of lymphocyte subpopulations of donors and patients with oncological diseases by flow cytometry method.Materials and methods.A panel of immunofluorescent probes (IFP) CD3FITC, CD4PE, CD8-Imd506, CD4-Imd306 was used in the work. Probes are obtained with MAB (ICO series) and fluorophores FITC, PE, Imd-306, Imd-506. The specific activity of the probes was evaluated in the immunofluorescence reaction by flow cytometry. Donor's peripheral blood was used to optimize the conditions of the immunofluorescence reaction. Clinical approbation of the obtained sets was carried out on 2 groups of patients with oncological diseases before and after surgical treatment. The first group included 64 patients with cancer of the oral mucosa. The second group consists of 35 patients with ovarian cancer.Results. We have shown that for the three-color analysis of human lymphocytes by flow cytometry, it is recommended to use sets of labeled MAB: CD3-FITC (10 μg/ml) + CD4-Imd306 at a concentration of 5–10 μg/ml; CD3-FITC + CD4-PE at a concentration of 20 μg/ml and CD3-FITC + CD8 Imd506 at a concentration of 10 μg/ml. The final concentration of immunoglobulin in the solution of IPS is indicated. It was shown that even before the beginning of treatment in patients with cancer of the oral mucosa the subpopulation CD3+ CD4+ content was significantly lowered in the structure of T cells, and the total level of CD8+ lymphocytes significantly exceeds the parameters of the donor group. Analysis of linear CD markers of lymphoid cells in patients with ovarian cancer revealed a significant decrease in the total number of CD3+ T-lymphocytes in comparison with donors. There was no evidence of the effect of surgical treatment on the subpopulation structure of lymphoid cells.Conclusion.Combinations of fluorescent probes CD3-FITC/CD4-Imd306/CD8-Imd506 and CD3-FITC/CD4-PE/CD8-Imd506 can be used for trichromatic analysis by flow cytometry of the lymphocyte subpopulations of both healthy donors and cancer patients. Comparative studies of the specific activity of combinations of IFP based on Mab ICO series and reference commercial test systems (BD Biosciences) on lymphocytes of healthy donors and oncological patients (ovarian cancer, oral mucosa cancer) showed comparable results. The application of the obtained probes made it possible to reveal violations of the subpopulation structure of peripheral blood lymphocytes in patients with ovarian cancer and cancer of the oral mucosa, in particular, CD3 – /CD8+, CD3+/CD4+, CD3+.


This paper reports on a patient who was treated by percutaneous aspiration, instillation of a sclerosant (polidocanol) and cystogastric drainage for a post-acute pancreatic pseudocyst. Five weeks after admission to hospital for the first episode of an acute necrotizing pancreatitis, the 60-year-old man underwent a percutaneous, ultrasound-guided puncture and aspiration of a voluminous pancreatic pseudocyst. Ten days later, recurrent fluid collection led to a second puncture, combined with the injection of polidocanol (15 ml; 1%) into the cyst cavity. Since this treatment failed, a percutaneous cystogastric drain ("double--pigtail") was inserted five days later. After developing acute abdominal pain and incipient sepsis, the patient was sent for surgical intervention twelve days after the second treatment with percutaneous aspiration and injection of polidocanol. During the operation an infected pancreatic pseudocyst with extensive contaminated necrosis of the pancreas and duodenal perforation was found. Necrectomy was performed, followed by continuous lavage of the omental bursa. Intensive care therapy was necessary for one week. Duodenal leakage persisted for nearly three weeks, the stopped spontaneously. The patient was discharged in quite a good state of health after 33 days of postoperative treatment. Although spontaneous development of infected pancreatic pseudocysts and pancreatic abscesses in necrotizing pancreatitis is known, a possible involvement of the drainage procedures, especially in combination with the injection of a sclerosant must be considered.


We have measured doubly differential cross sections for the (${\ensuremath{\pi}}^{+}$,${\ensuremath{\pi}}^{0}$) and (${\ensuremath{\pi}}^{\mathrm{\ensuremath{-}}}$,${\ensuremath{\pi}}^{0}$) reactions at 120- and 230-MeV kinetic energies for $^{40}\mathrm{Ca}$, $^{60}\mathrm{Ni}$, and $^{120}\mathrm{Sn}$. Nuclear-excitation energies up to 60 MeV were observed. We have extracted excitation energies, widths, and maximum cross sections for the isospin components of the isovector monopole resonance and the isovector dipole resonance. The excitation energies and widths from the present data and from earlier measurements at 165 MeV are compared and found to be in agreement. The cross sections for the isovector monopole and isovector dipole resonances show the same increase with bombarding energy in all targets. No isovector quadrupole strength is required to fit the experimental data. We compare the energy dependences of the isovector-resonance cross sections with those of isobaric-analog states, and to distorted-wave impulse approximation calculations.


In this paper, we disprove the following conjecture due to Goemans (1997) and Linial (2002): "Every negative type metric embeds into with constant distortion." We show that for every /spl delta/ > 0, and for large enough n, there is an n-point negative type metric which requires distortion at-least (log log n) /sup 1/6-/spl delta// to embed into l/sub 1/. Surprisingly, our construction is inspired by the Unique Games Conjecture (UGC) of Khot (2002), establishing a previously unsuspected connection between PCPs and the theory of metric embeddings. We first prove that the UGC implies super-constant hardness results for (non-uniform) sparsest cut and minimum uncut problems. It is already known that the UGC also implies an optimal hardness result for maximum cut (2004). Though these hardness results depend on the UGC, the integrality gap instances rely "only" on the PCP reductions for the respective problems. Towards this, we first construct an integrality gap instance for a natural SDP relaxation of unique games. Then, we "simulate" the PCP reduction and "translate"the integrality gap instance of unique games to integrality gap instances for the respective cut problems! This enables us to prove a (log log n) /sup 1/6-/spl delta// integrality gap for (nonuniform) sparsest cut and minimum uncut, and an optimal integrality gap for maximum cut. All our SDP solutions satisfy the so-called "triangle inequality" constraints. This also shows, for the first time, that the triangle inequality constraints do not add any power to the Goemans-Williamson's SDP relaxation of maximum cut. The integrality gap for sparsest cut immediately implies a lower bound for embedding negative type metrics into l/sub i/. It also disproves the non-uniform version of Arora, Rao and Vazirani's Conjecture (2004), asserting that the integrality gap of the sparsest cut SDP, with the triangle inequality constraints, is bounded from above by a constant.


To establish the spontaneous miscarriage rate and compare it with the procedure related miscarriage rate for amniocentesis and chorionic villus sampling (CVS) by experienced operators.


The rational design of hierarchically structured materials is of great significance for developing energy-storage devices. Herein, a novel and uniform chrysanthemum-like TiO2 nanostructure built by well-defined surface-folded nanorods (CLNR-TiO2) has been fabricated by a facile, effective and template-free synthetic method. By only changing the solvent in the reaction another two different morphologies have been obtained, including flower-like structures built by nanoplates (FLNP-TiO2) and microspheres (Microsphere-TiO2). As chrysanthemum-like nanostructures allow efficient Li+ ion diffusion, as well as have better structural stability, CLNR-TiO2 exhibits the best lithium storage performances among the three samples. A superior capacity up to 309.3 mA h g−1 is achieved at a current rate of 0.5 C (1 C = 170 mA g−1) for the first cycle with a high coulombic efficiency of 93.4% and it is significant for practical applications. At a high current rate of 5 C, a high reversible capacity of 198.3 mA h g−1 is obtained in 100 cycles (92% of capacity retention) with excellent rate capacity, high coulombic efficiency and good cycling stability.


Recently, the electromechanical oscillations are becoming the primary concerns in power grids due to the integration of renewable energy generations (REGs). The inherent characteristics of REGs, e.g. low or no inertia, stochastic generation, could lead to the lower damping margin in power systems. A supplemental control such as power system stabiliser or power oscillation damping (POD) controller is widely applied to augment the damping margin in power systems. However, the PSS or POD using local signal is not adequate to damp the oscillation contributed from different sources. Hence, a wide-area damping controller can be employed in this context. Nonetheless, the wide-area controller suffers from communication failure. Therefore, the wide-area controller with resilient to communication failures is inevitable. This study proposed a wide-area POD design method considering resiliency. A modified differential evolution algorithm is employed to synthesise the wide-area damping control. The two-area and Java-Indonesian (three-area) power systems are used to evaluate the performance of the proposed controller for oscillation damping. From the results, it is evident that the critical mode(s) of the system successfully damped by employing the proposed controller. It is also found that the proposed controller is robust against communication failures.


We have used whole-cell recordings and rapid agonist applications to characterize the physiological properties of kainate receptors expressed by rat hippocampal neurons in dissociated cell culture. Activation of NMDA and AMPA receptors was prevented by inclusion of the noncompetitive antagonists MK-801 (2 μm) and GYKI 53655 (100 μm), respectively. In the presence of these inhibitors, both kainate (EC50 = 23 μm) and glutamate (EC50 = 310 μm) evoked desensitizing currents. Maximal peak currents for kainate with GYKI 53655 were 15 ± 3% as large as in control solutions without GYKI. In contrast to currents mediated by AMPA receptors, kainate currents recorded in GYKI were blocked potently by lanthanum (IC50 = 2 μm) and were desensitized by 1 μm 2S,4R-4-methylglutamate (SYM 2081). Coapplication of either 5 μm AMPA or 500 μm aspartate had little effect on responses to kainate, although AMPA alone elicited current at 1 mm. In most cells, the currents evoked by kainate, glutamate, and SYM 2081 varied linearly with membrane potential and reversed near 0 mV. Kainate elicited substantial current at steady state (∼30% of peak), whereas responses to glutamate and SYM 2081 desensitized almost completely within 0.2–2 sec. Inhibition produced by a 10 sec desensitizing prepulse was half-maximal at 0.22 μm for SYM 2081 and 13 μm for glutamate. Recovery from desensitization to kainate and glutamate was >80% complete within 60 sec but was three- to fourfold slower after exposure to SYM 2081. Exposure to Concanavalin A blocked desensitization of the currents but also reduced the peak current amplitudes. Collectively, these results confirm that kainate-preferring receptors underlie the currents evoked by kainate, glutamate, or SYM-2081 in the presence of GYKI 53655; they are not mediated by electrogenic transport or by AMPA-preferring receptors that are insensitive to GYKI. In contrast to previous work on embryonic hippocampal neurons, our results show that the properties of kainate receptors expressed by cells from older animals are distinct from those displayed by homomeric assemblies of the GluR6 subunit.


Locating Africa on the global stage, this book examines and compares external involvement in the continent, exploring the foreign policies of major states and international organizations towards Africa. The contributors work within a political economy framework in order to study how these powers have attempted to stimulate democracy, peace and prosperity in the context of neo-liberal hegemony and ask who these attempts have benefited and failed.


The Malaysia Competition Commission (MyCC) was established on 1st April 2011.The MyCC came into force by virtue of the Competition Commission Act 2010 (CCA2010) on 1st January 2012. In 2017, the MyCC celebrated its 7th Anniversary. The objectives of the MyCC are to enhance consumer welfare, business practices and economic development. It has now been almost eight years that the MyCC came into existence and taking into account its enforcement activities and advocacy initiatives,there were only two studies conducted post three years of its existence related to impact study. The first baseline study was conducted in 2013 and the second study was the Study on awareness and perception of Competition Act 2010 (CA 2010) and the role of the MyCC in Malaysia which was conducted in 2016. However, both studies have something in common which is that the samples from both studies were not taken and conducted within the Putrajaya vicinity. Therefore, it is timely for the MyCC to conduct a study to examine the awareness level and factor on the role of the MyCC in the eyes of the consumers in Putrajaya. The target data samplings are consumers who work and reside in Putrajaya which includes the business community, government agencies, and students. This study is to determine consumer awareness on the role of the MyCC in improving consumer welfare, to determine the relationship between the factors of consumer awareness and the role of the MyCC in enhancing consumer welfare and to determine the most influential factor that contributes to the role of the MyCC in enhancing consumer welfare. For the purpose of gathering information, a set of questionnaire has been constructed. Moreover, the questionnaire has been validated by experts in the field of competition law. A total of There are 500 questionnaires in total that were provided and distributed to the consumers in Putrajaya. There are also several factors that have been determined in this study and those factors are advocacypro grammes, social media, and advertisements. For quantitative purposes Nevertheless,this study uses the Likert scale for data distribution which was included in the questionnaire. From the findings, it was found that the majority of respondents were neutral on consumer awareness on the role of the MyCC. The findings also show that there is a relationship between the factors of consumer awareness and the role of the MyCC in enhancing consumer welfare and it was also found that the highest factors relationship on the role of the MyCC in enhancing consumer welfare was advocacy programmes.


Logistics were known as the exclusive playfield of private economic stakeholders all along their impressive last thirty-year's history. And yet, it is obvious that a remarkable potential lies in them, still unexplored by governments and public authorities, namely, the means to achieve the strategic goal consisting in decoupling transport and traffic demand from economic development. Despite the fact that, at the business level, private economic actors are indeed the norm in logistics, the role of the public domain is not to be underestimated, for the latter can stimulate its development and enhance the national and regional development, notably by the creation of Freight Villages. In the past, the public authorities have shown a certain interest to logistics and more specifically to its spatial aspects. Its intervention has been unequal, shaped as it was along the lines of the various logic ruling the diverse European settings where such interest was shown. It follows that the public sector has not always been able to spot the real stakes of the logistics and to articulate the perspectives they open in the context of a coherent political plan. The sustainability of logistics is strongly related to the creation, management and governance of Freight Villages. Freight Villages can generate internal and external effects. The internal effects refer to the advantages accruing for the users from sharing the total acquisition and operating costs of common facilities, equipment and services offered; that is without having to proceed in heavy and risky investments for building their own, fully private, logistics centre. They also refer to the benefits from the increasing interaction between users. Besides the above, Freight Villages also generate larger-scale or external (network) effects, such as traffic diversion and modal shift, land use reorganization, changes in local economy, employment, energy consumption and the environment. Therefore, Freight Villages can be regarded as a blend of public facilities and business firms. The rationale behind the public investments is that of a public good, which reflects the external or network effects of a Freight Village and can be combined with larger-scale, regional policy objectives and plans. The rationale behind private investments relates to the economic viability and financial profitability of the project. Since such investments can combine both, Freight Villages have been progressively inserted in the political agenda of national authorities. Recently, the European Transport Policy also included the logistics infrastructure in its high priority agenda and encourages the creation of Freight Villages, especially in the framework of Public-Private Partnerships. Since the Freight Villages act as the interface between various logistic scales, it follows that their governance calls for an implication at various nested institutional levels. The governance methods employed in this perspective by the European countries which serve as examples deserve to be studied and taken into account in a more systematic fashion. This paper aims to perform a comparative analysis (benchmarking) of the policies dealing with regional development and logistics in various European countries. The paper will initially yield monographs of various European countries under scrutiny, in which the governance of the territorial dimension of logistics will be analysed. An analysis of the similarities and differences of respective countries' models will follow, a typology pattern will take form and the key elements of successful examples will be highlighted. Lessons to be learned and conclusions to be drawn will be presented. Finally, the paper will provide tools which facilitate decision-making and encourage effective changes in territorial governance of logistics, aiming towards greater sustainability of the supply chains. The methodological approach of the paper is that of benchmarking, i.e., of comparing international policies for logistics physical planning, and more specifically for promoting Freight Village developments along the lines of a specific common pattern of analysis. The standards employed to this effect correspond to the distinct aspects of governance models and the roles played by private and public stakeholders. The similarities and differences thus revealed will be conjugated in a composite presentation of the results, forming a typology, highlighting key elements of successful cases and indicating logical deductions to be made by decision makers.


The growing use of smartphones has been pointed out as one of the main reasons for the decrease in children's outdoor time. However, there is still a gap in our understanding of how smartphone use affects children's outdoor experiences and activities. The aim of the study is to explore children's dependency on their smartphones, what smartphone functions children use when outdoors and how smartphone use affects children's outdoor experiences. The study uses a mixed methods design which implements interviews with a small sample of children (N = 34) in order to help develop a questionnaire for a larger sample (N = 1148). Both datasets are included in the analysis with a complimentary perspective. The results suggest that children are highly dependent on having their smartphones available as an integrated part of their lives. However, smartphones also create favorable conditions for rich and valuable outdoor lives by expanding children's and parents' sense of security, children's outdoor sociality, and children's opportunities to mold their outdoor experiences. We stress that children's passion for the digital world needs to be reconsidered as not 'all bad', but more as a condition in modern children's lives and an asset to embrace in future strategies for actively engaging children in outdoor activities.


OBJECTIVE
The radiologic aesthetics of some body parts and internal organs have inspired certain artists to create specific works of art. Our aim was to describe the link between radiology and fine art. We explored 13,625 artworks in the literature produced by 2049 artists and found several thousand photographs in an online image search. The examination revealed 271 radiologic artworks (1.99%) created by 59 artists (2.88%) who mainly applied radiography, sonography, CT, and MRI.

CONCLUSION
Some authors produced radiologic artistic photographs, and others used radiologic images to create artful compositions, specific sculptures, or digital works. Many radiologic artworks have symbolic, metaphoric, or conceptual connotations. Radiology is clearly becoming an original and important field of modern art.


The potential influence that internal stakeholders' image of the organisation could have on external stakeholders' image of the organisation, is strongly supported in the literature. This research project attempted to address the need for an approach that facilitates employee engagement coupled with a leadership approach that allows collaboration, inclusion and cooperation within the organisation, to strengthen the internal corporate image. This article reports on the results of the second phase of this research project where a proposed stakeholder-inclusive conceptual framework for strengthening the internal corporate image, built from a stakeholderinclusive perspective as depicted in the King III report on corporate governance, was explored in practice. A quantitative, self-administered web-based survey was conducted with the 2014 winners of the Deloitte Best Company to Work For (BCTWF) survey. The results not only indicated that these organisations' practices resonate with the proposed stakeholder-inclusive framework, but also that the principles of the framework, namely; stakeholder theory; integrated internal communication; peace arena; stakeholder engagement by means of the AA1000 Stakeholder Engagement Standard (AA1000SES) and responsible leadership; and stewardship correlate with one another. The stakeholder-inclusive conceptual framework expands on the body of knowledge on corporate image and provides corporate communication professionals with a guide for strengthening their organisation's internal corporate image which could serve as starting point for strengthening the external corporate image and eventual corporate reputation.


Let g be a finite-dimensional complex semi-simple Lie algebra. We present a new calculation of the continuous cohomology of the Lie algebra zg[[z]] . In particular, we shall give an explicit formula for the Laplacian on the Lie algebra cochains, from which we can deduce that the cohomology in each dimension is a finite-dimensional representation of g which contains any irreducible representation of g at most once. MSC subject classification: 17B56, 17B65.


Patient: Female, 57-year-old Final Diagnosis: Malignant solitary fibrous tumor of the pleura • tumor embolism Symptoms: Bilateral numbness and tingling Medication: — Clinical Procedure: — Specialty: Cardiac Surgery • General and Internal Medicine • Oncology • Pathology • Radiology Objective: Rare disease Background: Solitary fibrous tumor (SFT) of the pleura is a rare fibroblastic neoplasm. It is commonly found incidentally on imaging and is usually benign but has significant potential to recur as a malignant tumor. Patients present asymptomatically or with pulmonary symptoms such as cough or shortness of breath. Cardiac invasion of an SFT can create an avenue for peripheral tumor embolization and critical limb ischemia, as in this case report. There is no prior published report of recurring malignant SFT presenting as critical limb ischemia. Case Report: We report a rare presentation of malignant SFT recurrence in a 57-year-old woman with critical limb ischemia of both lower extremities secondary to bilateral tumor emboli. The patient's primary tumor was treated with surgical resection alone. Upon recurrence, the tumor growth was so extensive that it was no longer amenable to surgical resection at the time of her critical limb ischemia. The patient presented with bilateral numbness and tingling, without any pulmonary symptoms. Conclusions: Although it is sporadic, clinicians should know that an aggressive malignant SFT can embolize and present as critical limb ischemia. The possibility of tumor emboli provides a pressing reason to surgically resect SFT masses in their early stages before any cardiac invasion.


Two primary granular-cell tumors of the breast are reported. Cytologically and histologically, these tumors had the classic features of small, eccentrically located nuclei and numerous periodic acid-Schiff-positive cytoplasmic granules. The characteristic cytologic features were best appreciated in touch imprints, not in frozen sections. Immunohistochemically, the tumors demonstrated diffuse cytoplasmic staining for S-100 protein but negative staining for myoglobin. The significance of these immunohistochemical staining characteristics, particularly in evaluating the possible histogenesis of these tumors, is discussed. The ultrastructural features of these two tumors are also presented and compared to findings reported by other investigators.


The infinite zero structure of linear multivariable systems is investigated via the geometric approach. The basic tools used are the new concepts of almost (A, B)-invariant and almost controllability subspaces. These concepts permit advantageous geometric interpretation of infinite zeros. This interpretation is a natural generalization of the finite case. Connection is made with the Smith McMillan structure at infinity of the transfer matrix. Structural properties of irreducible systems are investigated leading to a generalization of Morse theorem on prime systems.


A polarizable ion model is used to calculate the force constants for bending in the dihalides of the secondgroup metals. The results indicate that the bending constant is a sensitive function of the polarizability of the metal. The calculated constants are in moderate agreement with the experimental values. Some of the 'implicit assumptions of the model are discussed together with the implications of the calculated results.


We have isolated from a single human liver cDNA library two clones which are highly homologous (78% over the coding region) to the major phenobarbital-inducible P450 from rat (P450IIB1). This is the first direct demonstration of the presence of the P450IIB gene subfamily in humans. This subfamily is much less extensive than the rodent homologues, but does appear to contain at least two genes. Of the cDNA clones isolated one is apparently normally spliced, whereas the other lacks exon 8 and retains all or part of intron 5. Both clones contain transcribed Alu sequences. The human P450IIB gene has been located to chromosome 19q12----19q13.2 using a probe derived from intron 5, and is close to the CYP 2A locus encoding cytochrome P450IIA2. Restriction fragment length polymorphisms have been found with the enzymes BamHI and MspI which will enable linkage to be determined between these two loci.


Activation of mitogen-activated protein kinases (MAPK) is a critical signal transduction event for CTL activation, but the signaling mechanisms responsible are not fully characterized. Protein kinase C (PKC) is thought to contribute to MAPK activation following TCR stimulation. We have found that dependence on PKC varies with the method used to stimulate the T cells. Extracellular signal-regulated kinase (ERK) activation in CTL stimulated with soluble cross-linked anti-CD3 is completely inhibited by the PKC inhibitor bisindolylmaleimide (BIM). In contrast, only the later time points in the course of ERK activation are sensitive to BIM when CTL are stimulated with immobilized anti-CD3, a condition that stimulates CTL degranulation. Surprisingly, MAPK activation in response to immobilized anti-CD3 is strongly inhibited at all time points by the diacylglycerol (DAG)-binding domain inhibitor calphostin C implicating the contribution of a DAG-dependent but PKC-independent pathway in the activation of ERK in CTL clones. Chronic exposure to phorbol ester down-regulates the expression of DAG-responsive PKC isoforms; however, this treatment of CTL clones does not inhibit anti-CD3-induced activation of MAPK. Phorbol ester-treated cells have reduced expression of several isoforms of PKC but still express the recently described DAG-binding Ras guanylnucleotide-releasing protein. These results indicate that the late phase of MAPK activation in CTL clones in response to immobilized anti-CD3 stimulation requires PKC while the early phase requires a DAG-dependent, BIM-resistant component.


The topic of visualizing biological data has recently seen growing interest. Visualization approaches can help researchers understand and analyze today's large and complex biological datasets. The aim of this seminar was to bring together biologists, bioinformaticians, and computer scientists to survey the current state of tools for visualizing biological data and to define a research agenda for developing the next generation of tools. During the seminar, the participants formed working groups on nine different topics, reflected on the ongoing research in those areas, and discussed how to address key challenges; six talks complemented the work in the breakout groups. This report documents the program and the outcome of Dagstuhl Seminar 12372 "Biological Data Visualization".


The peripheral nervous system was analysed in the oral mucosa of eight patients with oral lichen planus (OLP), five with a lichenoid reaction (LR) and three with mild chronic inflammation (MCI), by morphometric analysis of nerve fibres containing immunoreactive PGP 9.5, substance P (SP), calcitonin gene-related peptide (CGRP), vasoactive intestinal polypeptide (VIP), or C-flanking peptide of neuropeptide Y (CPON). Overall nerve fibre density was higher in OLP (P=0.039) and LR (P=0.026) compared with healthy oral mucosa and was compatible with sprouting and collateral formation. In contrast to the innervation visualized with structural nerve fibre-marker PGP 9.5, the densities of neuropeptide-immunoreactive nerves were low in inflamed tissue. This is consistent with depletion via local release. Retraction and local loss of innervation were found in areas coinciding with the most severe inflammation and basal membrane (BM) damage. Interestingly, LR showed a twenty-eight-fold loss of post-ganglionic CPON-ir sympathetic nerve fibres (P=0.044). In LR, CPON-ir innervation was markedly lower than in OLP. Finally, the pattern of innervation in relation to inflammatory cell infiltrates and tissue structures differed between OLP and LR. In conclusion, the peripheral nervous system is implicated in the immunopathogenesis of lichen planus and lichenoid reactions, with a disorder-specific difference in this involvement.


This study examines the different degrees of sexual awareness shown among high school girls in urban and rural areas. The analysis was carried out by dividing these students into urban and rural groups. A questionnaire of 51 questions based on previous studies and a review of the literature was prepared for students in the two groups after two preliminary surveys, a reliability test, and correlation. There were 721 copies of the questionnaire in total which were distributed to students of 2 urban and 4 rural girls' high schools. The analysis of the results was carried out using by means of SPSS 10.0, and it became clear that girl's students' viewpoints toward sex, the actual circumstances of their acquaintance of the opposite sex, the access to information about sex, the content of current sex education at school and the ideal type of sex education, tended to show differences between the two groups. This study showed that the standardized and uniform content and methods of current sex education in public schools does not work properly. Sex education at schools in South Korea has reached a limit of their effectiveness to a point where research into more effective sex education is required.


Based on research of the river landscape, spatial variability of environmental values and their changes over time, it is possible to identify parameters which are in some way involved in the formation of runoff processes. In this paper the issue of the natural values disturbances in an environment of watercourse and its floodplain is solved on the example of two model sites. These are the lowland catchment areas of small watercourses in the Czech Republic. On basis of the map visualization of collected data, the authors deal with interpretation of the landscape spatial pattern within the context of its ecological stability. To analyze the areas, series of maps are used in the appropriate scale showing the selected indicators related to the environmental values. These indicators are a combination of the field research results and information gathered from the available data sources. The space is devoted to the analysis of relationships between selected environmental indicators of spatial character and their impact on the state of the river network. Analyzed are the consequences of human activities in the riparian zone of watercourses, with regard to the phenomenon of the river continuum degradation and changes in other hydrological variables that may affect the overall security of the floodplain area.


We present numerical conditions for the existence of natural degree-2 Abel maps for any given nodal curve. CoCoA scripst were written and have so far verified the validity of the conditions for numerous curves.


We report a case of combined levomepromazine-fluvoxamine treatment-induced seizures. It seems that combined treatment of fluvoxamine with phenothiazines may possess proconvulsive activity.


A study was conducted to evaluate the effects of energy and protein levels of maternal diets on growth, some blood parameters, health, and performance of baby goat kids at first month of life. On 95 d after successful mating, 28 synchronized singleton pregnant Sistani goats were randomly allocated to four treatments including 1) low protein and low energy (LPLE), 2) high protein and low energy (HPLE), 3) low protein and high energy (LPHE), and 4) high protein and high energy (HPHE) diets. In all treatments, body weight (BW) reduced at 1d and 28 d after party. The birth BW of kids was similar between the four groups but LPLE, LPHE and HPHE had numerically lower birth weight. The kids from nanny goats fed on high protein diets had greater BW and average daily gain (ADG) than those of others on days 7, 14, 21, 28. Plasma triglyceride and total protein were significantly high in HPHE and glucose concentrations were increased in HPLE. Milk production increased in response to prepartum crude protein (CP). The results show that maternal nutrition had a positive effect on weight and biometric traits of kids.


This paper explores Reliability Centered Maintenance (RCM) and Electrical Safety. Section 130.5 of NFPA 70E® Standard for Electrical Safety in the Workplace states that "the arc flash hazard analysis shall take into consideration the design of the overcurrent protection device and its opening time, including its condition of maintenance". This very important concept of "the maintenance condition" can be found in RCM. This paper will review and explore how RCM may be used to improve electrical safety and reliability. We will also look at the use of Condition Based Monitoring (CBM) and how and when to apply this approach to improve electrical safety in the workplace.


The respondents to the questionnaire also expressed the pros and cons of centralization. Those in favor of autonomous boards cited the need for professional expertise, administrative efficiency, insulation from political interference, and accountability. The advocates of centralization also claimed the virtues of administrative efficiency and better accountability. One regrets that the authors did not make any mention of the impact of &dquo;sunset legislation&dquo; since the licensing boards have generally been the favorite target of this weapon.


The incidence of local relapse after complete (R0) resection of solid tumors is largely determined by the skill of the surgeon, whereas metastatic relapse in distant organs is caused by pre- or perioperative systemic dissemination of tumor cells. The presence of individual disseminated tumor cells--e.g., in bone marrow as indicator organ--can be detected by sensitive immunocytochemical and molecular methods and is increasingly considered as a clinically relevant prognostic indicator. In contrast to solid metastases, isolated micrometastatic tumor cells are appropriate targets for intravenously applied anti-cancer therapeutics because they are easily accessible to macromolecules and immunologic effector cells. The majority of these tumor cells appear to be nonproliferating (i.e., in the G0 phase of the cell cycle), which may explain the failure of adjuvant chemotherapy. Adjuvant therapeutic strategies aimed at quiescent tumor cells are therefore of increasing interest. This therapeutic rationale has been tested and confirmed in a randomized clinical trial using antibody 17-1A in patients with non-metastatic colorectal carcinoma (UICC stage III). The antibody therapy kills also quiescent tumor cells ("dormant cells") and is independent from a potential chemotherapy resistance of the tumor cells. As treatment for minimal residual cancer, the clinical use of antibody therapy could be envisaged in conjunction with chemotherapy, applied either in parallel or sequentially. The aim of this review is to present and discuss the current state of research in the field of diagnosis and therapy of minimal residual cancer.


Induction chemotherapy can be effective in reducing locally advanced or aggressive cancers to improve their prospects of cure by planned follow-up surgery and/or radiotherapy. Systemic (intravenous) delivery is the simplest and most readily available method of administering induction chemotherapy. In some situations, a greater chemotherapy impact can be achieved by delivering a more concentrated dose of effective anti-cancer agents into the arterial blood supply of the cancer. Intra-arterial (i.a.) chemotherapy may or may not be advantageous. To achieve an advantage, the tumour must be fully contained in tissue supplied by one or more arteries that can be effectively cannulated and infused. The cancer must also be one known to respond better to concentrated chemotherapy and the agents used must be effective in the state in which they are delivered. The advantages must outweigh the likely increased risks of regional toxicity and experienced personnel and appropriate specialized equipment must be available to reduce any risk of mistakes made by the more exacting techniques of delivery. In general, systemic chemotherapy is most appropriate in treating tumours without a single artery of supply; when certain agents that are inactive until modified in body tissues (such as cyclophosphamide or DTIC) are to be used; when satisfactory responses can be achieved safely and more easily by systemic delivery; when technical skills and facilities for regional delivery are not available; or when the patient's general health, poor co-operation or long-term prognosis precludes the additional complexity of regional delivery. Intra-arterial infusion may have advantages in treating some locally advanced malignancies in the head and neck, a limb, some invasive stomach cancers and some breast cancers. Primary and some metastatic liver cancers, some pelvic cancers and possibly pancreatic malignancies may also respond well to initial direct chemotherapy infusion and are the subject of several studies. Closed circuit perfusion (Creech-Krementz), chemofiltration infusion and "stop-flow" perfusion (Aigner) and regional limb infusion (Thompson) are more complex techniques aimed at even greater localized initial tissue chemotherapy concentrations over a short time span. These are the subject of ongoing studies in highly specialized units. Their use is designed to achieve tumour responses in treating such malignancies as melanoma, some sarcomas or pancreatic cancer that usually show a poor response to standard systemic chemotherapy.


Neuroblastoma is a malignant embryonal tumor derived from the neural crest cells of the sympathetic nervous system. Curative therapy is challenging, especially because early-stage diagnosis in toddlers is difficult. Successful treatment of high-risk neuroblastoma is only achieved in approximately half of the cases and requires an immediate interdisciplinary approach. We present a 34-month-old toddler with swelling of the left side of the face of three days duration and a mandibular mass of unknown duration, which was diagnosed as a metastasis of a neuroblastoma. He also had metastases in the kidney, long bones and skull. Despite the poor prognosis in cases of disseminated skeletal involvement and N-myc amplification, the young patient remained free of recurrence during a follow-up period of 36 months after multidisciplinary treatment. The purpose of this case report is to increase awareness of the clinical features of neuroblastoma among pediatric dentists to support early-stage diagnosis and highlight interdisciplinary management.


Abstract 111 Background: Fc gamma receptor (FCGR) polymorphisms have previously been linked to outcome in follicular lymphoma (FL) patients treated with the anti-CD20 monoclonal antibody (mAB), rituximab, as a monotherapy. This is thought to be due to differences in binding affinity of host effector cells for the therapeutic antibody between individuals with different genotypes. In particular, the R/R genotype of FCGR2A and the F/F genotype of FCGR3A have been correlated with a less favorable outcome compared to the higher affinity FCGR genotypes H/H and V/V, respectively. Previous studies have had relatively low statistical power and have used consecutive series of patients and the prognostic significance remains largely untested. Therefore, we questioned whether this association would hold up in the context of a chemotherapy regimen combined with a monoclonal antibody in a larger set of patients treated on Southwest Oncology Group (SWOG) clinical trials. Specifically, we wished to test whether the genotypes were predictive of survival following all treatment regimens, or just the regimens containing mAB. Methods: Excess paraffin embedded tissue from 146 patients previously treated on SWOG clinical trials with chemotherapy alone (protocol S8809, N=70) or combined chemotherapy and mAB (anti-CD20 antibodies rituximab or I-131 tositumomab on protocols S9800 and S9911, N=33 and 43 respectively) were analyzed. DNA was extracted using the Qiagen RNA/DNA kit, then assayed for the R131H polymorphism (rs1801274) in FCGR2A and the V158F polymorphism (rs396991) for FCGR3A using a TaqMan SNP assay. Stratified Cox regression was used to assess marker associations with overall survival (OS). Results: Patients in each clinical trial had similar IPI and FLIPI scores. Overall frequencies of the FCGR2A genotypes were 27% H/H, 54% R/H, 16% R/R. Frequencies of the FCGR3A genotypes were 36% FF, 41% VF, and 8% VV. There were no differences in genotype frequencies between trials and no associations between genotypes. Neither FCGR 2A nor 3A were associated with survival in S8809 (chemotherapy only). In S9800 and S9911 (chemotherapy + mAb), having at least 1 FCGR2A H allele was weakly associated with improved OS vs R/R (hazard ratio [HR] 0.42, 95% confidence interval [CI] 0.16–1.12, p=0.06), and having at least 1 FCGR3A V allele was more strongly associated with improved OS vs F/F (HR 0.28, 95% CI 0.10–0.80, p=0.02), with 5 year OS of 72% for F/F, 97% for V/F, and 100% for V/V. The interaction term between antibody usage and FCGR3A genotype was significant (p=.01), suggesting that the effect of this marker may be truly different in 9800/9911 than in 8809. All survival analyses held up after adjustment for IPI score. Summary: Overall, we found an association of FCGR3A genotype with overall survival in patients treated with chemo + mAB (rituximab or I-131 tositumomab). An association with survival was not identified in patients treated with chemotherapy alone. Interestingly, in the analysis of the overall dataset we found significant evidence of an interaction between mAb therapy (S9800/S9911 vs. S8809) and FCGR3A. This study suggests that FCGR3A polymorphism status may be predictive of survival in FL patients given mAB-containing treatment as opposed to any treatment in general. Therefore, FCGR3A polymorphism status may be an important factor to consider in designing new FL trials with mAB-containing regimens. Disclosures: Persky:Millennium, The Takeda Oncology Company: Consultancy, Research Funding. Dornan:Genentech, Inc.: Employment, Equity Ownership. Fisher:Genentech: Honoraria, Speakers Bureau. Maloney:Genentech, Biogen Idec, GSK: Membership on an entity9s Board of Directors or advisory committees. Miller:Genentech: Consultancy, Honoraria, Membership on an entity9s Board of Directors or advisory committees; Spectrum Pharmaceuticals: Research Funding; Milleneum: Consultancy. Rimsza:Genentech: Research Funding.


HUNTED HERETIC; THE LIFE AND DEATH OF MICHAEL SERVETUS 15111553. By Roland H. Bainton. Boston, Beacon Press, 1953. xii, 270 pp. $3.75. The Reverend Roland H. Bainton is the distinguished Titus Street Professor of Ecclesiastical History at Yale University. For over twenty-five years Mr. Bainton has been studying about and publishing books on the four principal heretics of the Reformation who, as he puts it, "fled from Catholic countries to the Swiss cities and there fell foul of the Calvinist regime." The Hunted Heretic is the last of four monographs on the heretics; Mr. Bainton's earlier monographs on Castellio, Joris, and Ochino appeared respectively in 1935, 1937, and 1940. This present work appeared on the 400th anniversary of the burning of Servetus at the stake in Geneva on 27 October 1553. Servetus was one of those men of the sixteenth century who was active in many fields of knowledge. He was linguist, Biblical scholar, theologian, geographer, physician, and physiologist. It is as physiologist that he is of most interest to biologists and physicians today; Servetus independently discovered the pulmonary transit. Mr. Bainton has written a very readable book. He has made extensive use of original sources both printed and manuscript, and he has achieved a remarkably scholarly and interesting interpretation of Servetus. I use the phrase "remarkably scholarly" because even a casual acquaintance with Servetus literature will convince anyone that perhaps as much fiction has been written about him in the guise of fact as about any other one man. Hunted Heretic is an outstanding exception. The history of the discovery of the pulmonary transit is also replete with conjecture. In fact the whole story seems to have gotten off on the wrong foot (right or left?) when William Wotton first publicized Servetus' discovery in his Reflections on Ancient and Modern Learning (London, 1694). In this work Wotton reported "he [Servetus] clearly asserts, that the Blood passes through the Lungs, from the Left to the Right [!] Ventricle of the Heart." Mr. Bainton's discussion of Servetus' discovery, like the rest of his book, is interesting and accurate. It is the best brief statement available. FREDERICK G. KILGOUR


At a vacant lattice cell positron-ion repulsion is reduced leading to positron trapping. This causes observable changes in annihilation characteristics: positron lifetime increases and positron-electron momentum distribution narrows. Positron trapping in semiconductors is analogous to carrier capture. Due to long-range Coulomb interaction, the charge state of a vacancy has strong effect on positron trapping. Also the lattice relaxation due to a charge-state transition of a vacancy is well seen in positron lifetime. Thus ionization levels of vacancy defects can be determined. Positron lifetime results on vacancies in GaAs will be discussed. Positrons reveal As and Ga vacancies in as-grown bulk GaAs. The As vacanacies have negative, neutral and positive charge states in the upper part of the band gap, whereas Ga vacancies are negative. The EL2 defect is shown to have a vacancy character in its metastable state.


Understanding the properties of small particles working under high-temperature conditions at the atomistic scale is imperative for exact control of related processes, but it is quite challenging to achieve experimentally. Herein, benefitting from state-of-the-art mass spectrometry and by using our newly designed high-temperature reactor, the activity of atomically precise particles of negatively charged vanadium oxide clusters toward hydrogen atom abstraction (HAA) from methane, the most stable alkane molecule, has been measured at elevated temperatures up to 873 K. We discovered the positive correlation between the reaction rate and cluster size that larger clusters possessing greater vibrational degrees of freedom can carry more vibrational energies to enhance the HAA reactivity at high temperature, in contrast with the electronic and geometric issues that control the activity at room temperature. This finding opens up a new dimension, vibrational degrees of freedom, for the simulation or design of particle reactions under high-temperature conditions.


The purpose of this study is to develop and evaluate the program which aims at providing a better understanding of family role, establishing a desirable value of being good spouse and good parent, and good daughter/mother in-law and determine effects of the program on rural women in Gyeonggi do. Based on the strong & healthy family perspective, personality types theory, coping stress theory, anger control method, communication & conflict solution theory(eg; Minnesota Couple Communication Program), cognitive behavior theory, and relations enrichment theory, 6 session program was developed. The title of 6 sessions were 'Making happy family', 'Family communication', 'Coping parent-child relation stress', 'Coping conjugal personality difference', 'Becoming a good mother/daughter in-law', and 'Dissolving family conflict'. 188 women surveyed were asked to participate in the program held at 5 city located in Gyeonggi do from Jun. 22 to July, 15. 2005, with two days(3 session a day and 120 minutes per session based). The effectiveness of this program was evaluated by pre-test, post test through 188 rural women and it was analyzed by paired t-test and program evaluation questionnaire was also investigated. The major results were as follows: This program was effective in improving spouse relation satisfaction, child relation satisfaction, daughter/mother in-law relation satisfaction, their effort for making happy family, self-esteem, and depression tendency. Future research and practical implications were added.


Modular and offsite construction (O/M) has been on the agenda of the construction industry to improve its overall performance for some time. However, the existing body of research on O/M focuses mostly on the housing and building sector. This paper explores O/M in civil infrastructure projects as part of efforts associated with likening the Engineer-to-Order (EtO) construction industry to Assembly-to-Order (AtO) industries. By studying four highways construction projects in the UK as cases and collecting expert opinions, the current O/M condition is explored and a set of barriers and opportunities for O/M in the highways supply chain is presented


Abstract The scientific contribution of this paper consists of an innovative approach to the issues of Orthodox faith and sport, which opens up a new creative area for theology itself, where sport also gets new opportunities. Given the known "affair" in almost all sports branches, which illustrate the state of "alarming helplessness", the contribution of faith in solving it is indisputable, especially in the way advocated in this research work. The primary goal is to extract from the plethora of theological literature those contents that can encourage the creative responsibility of all positive factors of sports events, from the athletes themselves, through their managers and club officials to the fans. Recognizing these problems and referring to theological sources as "clear content", without the bias of the members, with critical awareness, qualifies work to search and find adequate answers to the asked questions. The mere fact that a new research field has been opened, without the intention to make the last word on this, points to the scientific contribution of this paper.


The conventional method for determining the parameters of the transformer is to performing the open and short-circuited tests. The method is only suitable for off-line application. This paper presents an alternative approach to conventional open and short-circuit test for determining the parameters of N-windings transformer operating at power frequency on an on-line mode. This approach is based on linear least errors square (LES) algorithm and uses the digitized samples of the input current and voltage as well as the output current and voltage of the transformer windings. The proposed algorithm estimates the winding parameters in two steps; while in the first step the algorithm identifying the winding parameters, in the second step, the algorithm identifying the core parameters. The proposed algorithm is applied to a two-windings transformer and simulated results are reported in this paper.


recent publication with the same problem. Regrettably, most of what he could glean from the Coles's discussion was a set of indisputable moral homilies on the need for a balance between &dquo;human freedom&dquo; and &dquo;social responsibility.&dquo; The central problem-area of social structure (intermarriage, cliques, community organization, institutional affiliation) was bypassed. While in its most ambitious areas the volume under review may not have wholly succeeded, at least it has raised some of the right questions. Moreover, as a summary for the layman of the setting of in, tergroup relations and of recent pertinent developments in such areas as employment, housing, religion, and education, the general worth of the study is considerable. The book would be particularly valuable in the hands of interested nonspecialists and members of adult study groups who want recent information about intergroup relations in a volume of modest size written in nontechnical language. MILTON M. GORDON Haverford College


A sensor in order to communicate with another sensor within the sensor network needs to find out the sensor which is adjacent to it. So within the network, a sensor needs to find out its adjacent sensor and communicate with it. In order to communicate it needs to maintain some authentication information. The information must be transferred securely. If the sensors are mobile then it is difficult to expect the adjacent sensors. So each sensor has to maintain the information of all other sensors. This increases the non-data overhead. So, if there are 'n' sensors within the network then each sensor has to maintain the keys of the remaining 'n-1' sensors (which is 'n*(n-1)') for the network. So through our project we reduce the keys information from 'n-1' to a maximum of '(n+1)/2'. This could be achieved with the help of a new concept called 'Key Sender. In this paper we are used TDEA algorithm for the encryption purpose.


The ionizing radiation (150 Gy) extended the rat tail flick latency, decreased the pain-relief effects of morphine and opioids and enhanced the analgesic effect of clopheline. The radiation was followed by a decrease of vocalization threshold with a reduction of morphine- and clopheline-induced analgesia. Naloxone (0.1 mg/kg) eliminated the postradiation analgesia and did not change the hyperalgesic effect of the radiation.


Demodex mites are ectoparasites often found in the skin thought to be associated with the development of some skin diseases. Demodex positivity may be affected by several factors. In order to determine the relationship between Demodex infestation and rosacea disease (RD), Behcet's disease (BD) and various individual parameters such as gender, personal hygiene and skin type. A total of 238 individuals (61 with RD, 46 with BD, and 131 healthy subjects) were investigated for the presence of Demodex folliculorum and D. brevis using the standardized skin surface biopsy technique and a questionnaire. The incidence of Demodex mites in RD patients was significantly higher when compared to the control group (p=0.010 and p=0.001, respectively). However, there was no difference between those with BD and the control group. There was a significant difference between ages of groups, skin types, use of moisturizer, and itching, without taking into account the presence of Demodex among the disease groups (p<0.05). On the other hand, there was no significant difference between disease groups in terms of data of gender, skin care, epilation, and face washing. Our study reveals that the positivity rates of Demodex mites in rosacea patients were significantly higher. Mean ages of groups, skin types, use of moisturizer, and the presence of itching of the ear and face may be associated with higher density of Demodex mites.


Internet censorship has been a popular topic both in academia and in the popular press. A fundamental question that has not been fully addressed is how censorship is perceived by people who experience it. A person may exhibit pro- or anti-censorship attitudes, but it is possible that (s)he may not even be aware of its existence. In this study, we report results of a large-scale survey on Chinese Internet users' experiences with Internet censorship. The results show that users' demographic backgrounds, Internet usage experience, and personality influence their attitudes toward censorship. Those who score high on authoritarian personality measures tend to support censorship. Attitudes toward censorship change so that over time it is viewed as more normal, which suggests a "normalization" process. We discuss how these findings can generalize beyond the Chinese context to other societies in which Internet censorship can exist.


Objective To examine whether switching to and from Daylight Saving Time (DST)—1 h shift forward in the spring and 1 h shift back in the autumn—is associated with an increase in work injuries. Method Data on work-related injuries were obtained from compensation claim records from the Ontario Workplace Safety & Insurance Board for the period 1993–2007. A Poisson regression model was run separately comparing the number of no lost time claims and lost time claims during the week of DST change with the week following DST change, and the week preceding DST change. We also examined if differences in the relationship between DST and work injury claims were present across industry, age, gender and job tenure groups. Results The results of our regression model did not show an increase in the incidence of work injury claims in the days immediately following the spring shift to DST. There was a significant decrease in the number of claims on Thursday, Friday and Saturday following the spring transition to DST. However, this decline was solely due to the years when Good Friday occurred during DST week (1993, 1998 and 2004) when fewer people are at work. For the autumn transition from DST, no evidence was found that the gain of 1 h sleep results in a decrease or increase in work injury claims. Conclusion Our findings show that the shift to and from DST had no detrimental effects on the incidence of claims for work injuries in Ontario, Canada.