Background and Purpose—Arterial recanalization and subsequent reperfusion have extensively demonstrated their ability to restore the brain function when performed shortly after acute ischemic stroke. However, arterial recanalization does not necessarily lead to brain tissue reperfusion. Summary of Report—This review provides an update of current approaches to improve the efficacy profile of brain tissue reperfusion within and beyond the therapeutic window, including the use of novel thrombolytic agents, bridging intravenous and intra-arterial therapies, and mechanical clot retrieval or aspiration. Conclusions—There are still several challenges in the near future of reperfusion therapy for acute ischemic stroke, such as improving the ultra-early access to treatment within the "golden hour," extending the therapeutic window beyond the current 4.5-hour time window, and developing novel thrombolitics or combined approaches to improve treatment efficacy. (Stroke. 2011;42[suppl 1]:S16-S19.)


It is well accepted that hyperventilation before breath hold swimming and diving makes it possible for a person to extend the time under water. Less well known is the fact that this maneuver can cause loss of consciousness due to hypoxia. This accident happens almost exclusively to males (56 cases). The most common age group was 16-20 years (range 12-33 years). All were known to be good swimmers or divers. Approximately 80% of the cases occurred in guarded pools. Thirty-five subjects survived the accident and of the twenty-three fatalities, there was only one good autopsy report. In this instance the findings were those associated with classical drowning preceded by hypoxia and hypercapnia. Breath holding experiments indicated that the times between loss of consciousness and death may be no longer than 2.5 minutes. The patterns associated with these cases suggest that those who are responsible for aquatic safety as supervisors or guards of pools could prevent most accidents by watching for young male swimmers who are practicing hyperventilation and underwater swimming in competition with themselves or with others.


The Global navigation satellite system (GNSS) multi‐mode compatible and multi‐frequency information not only improves information redundancy but also eliminates errors such as ionospheric delays to improve positioning performance. However, multi‐mode and multi‐frequency observation information increases the hardware overhead and computational complexity, especially the signal acquisition. In this contribution, according to the strong complementarity between GNSS and Strapdown inertial navigation system (SINS) and the sparsity of the GNSS signal spreading code in the autocorrelation domain, a SINS‐aided fast acquisition method for GNSS signals based on Compressive sensing (CS) is proposed. First, the inertia information of SINS narrows the Doppler frequency search range; then, the CS is applied to measure compressively the GNSS signal in two steps, ie, the first step is to narrow down the code phase search range, and the second step is to determine the code phase of the half chip accuracy. Finally, the proposed method and the other two typical acquisition methods are compared by the detection probability and the Mean acquisition time (MAT). Theoretical analysis and experimental results show that the proposed method can not only reduce the number of correlators and computational complexity but also improve the detection probability and reduce the MAT.


RSD is a complex syndrome in which large-scale prospective research is needed to provide additional answers regarding variations in presentation and therapeutic outcomes. Only with the early administration of sympathetic blocks in addition to adjunctive therapies will pain relief and return to normal function be most assured.


A recently developed machine learning algorithm referred to as Extreme Learning Machine (ELM) was used to classify machine control commands out of time series of spike trains of ensembles of CA1 hippocampus neurons (n=34) of a rat, which was performing a target-to-goal task on a two-dimensional space through a brain-machine interface system. Performance of ELM was analyzed in terms of training time and classification accuracy. The results showed that some processes such as class code prefix, redundancy code suffix and smoothing effect of the classifiers' outputs could improve the accuracy of classification of robot control commands for a brain-machine interface system.


This study builds upon the National Academy of Sciences study in the rapidly changing area of diesel particulate cost-benefit analysis and updates it where appropriate based on new data or analysis. It does not generate new information but merely reviews and analyzes existing data. The body of the paper a) explains the basis for estimating the various costs, b) describes a computer model to relate the costs to the benefits, and c) presents the results of the analysis.


A myriad of factors affect stream fish assemblages, and most of them are intimately regulated by surrounding land uses. One of the most pernicious impacts on streams is the release of urban effluents. Accordingly, understanding the fish assemblage patterns as well as the environmental drivers that modulate them in the context of urban streams which also are exposed to other land uses is mandatory. We evaluated the longitudinal patterns of fish assemblages in an urbanised Neotropical prairie stream exposed to downstream patches of different surrounding land uses. Several variables of water quality, in-stream habitat and riparian corridors were measured, and their relationships with fish metrics were explored. A fish metric selection protocol was im - plemented, and several multivariate analyses were used. Three main patterns of fish response were observed. Assemblage-level attributes as diversity, richness, biomass, number of families and trophic guilds and proportion of Characiformes and intoler-ant species were responsive to the natural gradient in habitat (pools) and riparian (riparian width) conditions expected in non-impacted lotic ecosystems. Conversely, a downstream continuum of recovery in water quality (dissolved oxygen, conductivity, NO3:NH4 and bacteriological loads) and habitat structure (sediment depth) would influence the distribution of fish species regarding their environmental tolerance and habitat preferences. Finally, local habitat aspects (nitrites, submerged macrophytes, bare soil cover and bank incisions by livestock) seemed relevant for the trophic structure (omnivorous species) of fish assemblages. A complex natural and anthropic lon - gitudinal scenario together with local disruptions imposed by surrounding land uses were directive for fish.


Evapotranspiration models require thermodynamic temperatures as a state variable characterizing the surface energy balance. The thermodynamic temperature is calculated using the brightness temperature and the emissivity because no effective method exists to measure thermodynamic temperatures in space and time. A method was therefore developed to measure thermodynamic temperatures in time using contact probes and spatial variations of the thermodynamic temperature using a thermal camera. Using an extraction scheme, the brightness temperatures of canopy and soil were extracted from the thermal images and compared with the contact temperatures. The contact temperatures had similar amplitudes and time‐variability as the brightness temperatures for both components. The slope and offset parameters of a scatter plot were calculated. The slope of the scatter plot was lower than unity for canopy, and higher than unity for soil. Because of the spread in the scatter plot, the emissivities of the components could not be calculated. We conclude that kinematic temperature measurements by contact probes can be a valuable extension to current techniques for measuring continuous component temperatures. The extraction scheme could be a useful tool for extracting the component brightness temperatures for low‐resolution imagery.


Abstract Objective The COVID-19 pandemic is a care crisis of unknown duration which has seemingly not yet reached its peak in many countries. A significant number of elderly and frail people and those with underlying serious illness will continue to develop severe forms of the COVID-19 infection. Most of them are not eligible for intensive care treatment but can still expect palliative care — in many cases provided by a Hospital Palliative Care Team (HPCT). Several teams have already gained experience in caring for these patients and their families, others are preparing for it. Method We report on a COVID-19 patient with pre-existing acute myeloid leukemia who was looked after by a HPCT until death. We discuss the challenges and difficulties while caring for COVID-19-positive palliative patients in a non-ICU setting. Results Hospitalization of the patient in an isolation ward caused an enormous burden for the dying patient and his family. Symptom control was particularly difficult because of rapid deteriorating dyspnea and the scarce presence of medical staff in the patient's room. Significance of results COVID-19 patients who are not eligible for ICU treatment may have a particularly high need for palliative care. Since beds in specialist palliative care units are limited, the HPCT should be prepared to care for these patients. They may offer support in decision-making, optimize symptom control, and provide psychosocial care for patients and their families. Visiting restrictions aimed to protect the general public must be weighted against the patient's and family's suffering.


Polytomous Item Response Theory Models provides a unified, comprehensive introduction to the range of polytomous models available within item response theory (IRT). It begins by outlining the primary structural distinction between the two major types of polytomous IRT models. This focuses on the two types of response probability that are unique to polytomous models and their associated response functions, which are modeled differently by the different types of IRT model. It describes, both conceptually and mathematically, the major specific polytomous models, including the Nominal Response Model, the Partial Credit Model, the Rating Scale model, and the Graded Response Model. Important variations, such as the Generalized Partial Credit Model are also described as are less common variations, such as the Rating Scale version of the Graded Response Model. Relationships among the models are also investigated and the operation of measurement information is described for each major model. Practical examples of major models using real data are provided, as is a chapter on choosing an appropriate model. Figures are used throughout to illustrate important elements as they are described.


BACKGROUND
We sought to compare the efficacy of tirofiban and abciximab on platelet inhibition as well as their effects of platelet inhibition on C-reactive protein levels during percutaneous coronary intervention (PCI).

METHODS
Using a randomized, double-blind study design, 95 consecutively eligible patients were randomized to receive either tirofiban or abciximab before undergoing native coronary artery revascularization with a stent. Clinical endpoints were death, nonfatal MI, target vessel revascularization (TVR) with coronary artery bypass grafting or PCI within 30 days of the study procedure. The medications were compared for differences in platelet aggregation as measured by a rapid function platelet assay, as well as measurements of the inflammatory marker C-reactive protein (CRP) at frequent intervals following drug administration during PCI.

RESULTS
A total of 95 patients were randomized to abciximab (n = 44) or tirofiban (n= 51). There was no significant difference in platelet aggregation documented throughout the procedure (10-, 20-, 30-, 45-minute time points). In diabetic patients abciximab had significantly lower platelet inhibition as compared to tirofiban at 10 minutes (84.17 +/- 8.28% vs. 90.40 +/- 5.79%; p = 0.0097). Using a Spearman correlation coefficient model, hs-CRP demonstrated an inverse relationship with platelet inhibition over time (-0.7307, p = 0.0002) in patients treated with abciximab.

CONCLUSION
There is no major difference in platelet inhibition between tirofiban and abciximab during PCI. In this study, tirofiban showed a greater inhibition in diabetic subsets at the first time point within PCI. Platelet inhibition may be inversely related to the levels of CRP during PCI.


Abstract The human Bowes melanoma cell line secretes a plasminogen activator identical to the extrinsic tissue plasminogen activator (EPA) and different from the urokinase-like plasminogen activators mostly found in human tumor lines. In the continuous presence of 100 ng/ml of phorbol 12-myristate 13-acetate (PMA) the 24-hr production of EPA was increased 5.3-fold (average). Preincubation of the cultures for a limited time period (optimally 3 to 6 hr) also resulted in an increase of the subsequent 24-hr production. EPA produced in the presence of PMA was serologically indistinguishable from that produced spontaneously and its molecular weight as denned by sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis and fibrin-agar zymography was the same as that of spontaneously produced EPA. Treatment of the cells with actinomycin D inhibited PMA-induced EPA production. Also, RNA extracted from PMA-treated cells became enriched in mRNA for EPA. It is concluded that PMA acts by enhancing the transcription of the EPA gene. Cell-associated EPA levels were increased, even when tested as early as 3 hr after initiation of the PMA treatment, thus failing to support the view that increased EPA synthesis occurred as a result of depletion of the cellular pool.


Objective The aim of this study was to evaluate a narrowly trained convolutional neural network (CNN) denoising algorithm when applied to images reconstructed differently than training data set. Methods A residual CNN was trained using 10 noise inserted examinations. Training images were reconstructed with 275 mm of field of view (FOV), medium smooth kernel (D30), and 3 mm of thickness. Six examinations were reserved for testing; these were reconstructed with 100 to 450 mm of FOV, smooth to sharp kernels, and 1 to 5 mm of thickness. Results When test and training reconstruction settings were not matched, there was either reduced denoising efficiency or resolution degradation. Denoising efficiency was reduced when FOV was decreased or a smoother kernel was used. Resolution loss occurred when the network was applied to an increased FOV, sharper kernel, or decreased image thickness. Conclusions The CNN denoising performance was degraded with variations in FOV, kernel, or decreased thickness. Denoising performance was not affected by increased thickness.


Multilocular cystic nephroma is an uncommon renal neoplasm which have two peaks in the incidence, one is in the childhood and the others is in the middle age group. This tumor is easily confused with other renal neoplasm in clinically, radiologically, and pathologically, particularly nephroblastoma. The clinical presentation, radiological findings, differentiated diagnosis and treatment in one case of multilocular cystic nephroma is described.


An unsuspecting motorcycle passenger was ambushed and impaled on the right side of the head with a 30cm serrated meat carving knife during a sectarian crisis in the city of Jos, Plateau State, Nigeria. The patient escaped running with the knife in his head and was rescued to a military hospital from where he was promptly transferred within 90 minutes of the incident to the Emergency Department of Jos University Teaching Hospital (JUTH), Jos. Prompt resuscitation and CT brain imaging facilitated a successful neurosurgical intervention and a good outcome in the management of this patient.


The mouse immune response against Neisseria meningitidis was studied by using an extract from group Y (Slaterus) known to contain protein antigens common to other meningococci. By using a solid-phase radioimmunoassay, high titers of specific IgM and IgG class antibodies were measured which lasted over 2 months after immunization. These antibodies cross-reacted with similar extracts from other meningococci groups. Bactericidal antibodies directed against protein antigens were also elicited after immunization and they belonged to IgM, IgG2a, and IgG2b isotypes. Cellular immunity, expressed as delayed type hypersensitivity under the conditions tested, could be detected neither in homologous nor heterologous reactions.


BACKGROUND
Choledochal cyst is a rare congenital anomaly of the biliary tract. With increased familiarity with the laparoscopic anatomy of the biliary tract and advances in minimally invasive techniques, surgeons have ventured further to operate on technically difficult cases such as choledochal cyst that were until recently managed by laparotomy.

PATIENTS AND METHODS
We present our experience with two female patients aged 14 years and 26 years with choledochal cyst (type I according to the Alonzo-Lej classification) that were successfully excised with construction of a Roux-en-Y hepaticojejunostomy entirely laparoscopically.

RESULTS
Both patients had an uneventful recovery, with no major morbidity. The first patient had a bile leak, which resolved over 5 days. Both were discharged by the 5(th) postoperative day.

CONCLUSION
Laparoscopic management of choledochal cyst is feasible although technically difficult and may be performed in specialized institutes dealing with advanced laparoscopic surgery.


Dense systems of magnetic nanoparticles may exhibit dipolar collective behavior. However, two fundamental questions remain unsolved: i) whether the transition temperature may be affected by the particle anisotropy or it is essentially determined by the intensity of the interparticle dipolar interactions, and ii) what is the minimum ratio of dipole-dipole interaction (Edd ) to nanoparticle anisotropy (Kef V, anisotropy⋅volume) energies necessary to crossover from individual to collective behavior. A series of particle assemblies with similarly intense dipolar interactions but widely varying anisotropy is studied. The Kef  is tuned through different degrees of cobalt-doping in maghemite nanoparticles, resulting in a variation of nearly an order of magnitude. All the bare particle compacts display collective behavior, except the one made with the highest anisotropy particles, which presents "marginal" features. Thus, a threshold of Kef V/Edd  ≈ 130 to suppress collective behavior is derived, in good agreement with Monte Carlo simulations. This translates into a crossover value of ≈1.7 for the easily accessible parameter TMAX (interacting)/TMAX (non-interacting) (ratio of the peak temperatures of the zero-field-cooled magnetization curves of interacting and dilute particle systems), which is successfully tested against the literature to predict the individual-like/collective behavior of any given interacting particle assembly comprising relatively uniform particles.


Dried Citrus unshiu peels (Aurantii Nobilis Pericarpium; ANP) are used as a traditional folk medicine for the treatment of gastrointestinal (GI) motility disorders in East Asia, including Korea. In the present study, an ethanolic extract of ANP (ANP-E) exhibited no significant toxicity in mice, even at an oral dose of 5 g/kg. The effects of ANP-E on GI motor function were investigated by measuring the intestinal transit rate (ITR) of Evans blue in normal mice and mice with experimental GI motility dysfunction (i.e., peritoneal irritation by acetic acid; PIA). In normal mice, ANP-E significantly increased the ITR in a dose-dependent manner. The ITR in the PIA mice was significantly retarded compared to that in the normal mice. However, ANP-E significantly inhibited this retardation in a dose-dependent manner. Furthermore, in all the models, the potency of ANP-E appeared to be same or higher than that of cisapride, which was used predominantly for the treatment of various GI motility disorders in humans in the 1900s but was removed from the market in 2000 due to fatal side effects. The results suggest that ANP-E has potential as a new prokinetic agent that could be used as a substitute for cisapride.


The population complexity associated with superdiversity brings a wide range of challenges for social welfare providers. Commentators have outlined concerns about the ability of service providers to meet the welfare needs of ever diversifying populations and point to potential problems in identifying the nature of need in rapidly changing superdiverse neighbourhoods as conventional approaches to consultation based around ethnicity become practically impossible. Using data collected in the West Midlands, which explored maternity service needs from the perspectives of new migrants and maternity professionals, some key barriers to effective welfare delivery in superdiverse areas are explored. The paper outlines the emergence of two challenges important in shaping new migrant access to maternity care in an era of superdiversity – novelty and newness – and proposes further research to examine the extent to which these challenges are faced in other social welfare services.


We consider sender-initiated dynamic load balancing policies in distributed computer system with star topology. In this system, the processing power of central node may be greater than that of peripheral nodes and the job arrival rate of each node may be different. The performance of load balancing may be very different according to the selection of sender criteria and receiver criteria for job transfer. But the optimal decision of sender and receiver criteria is very difficult in heterogeneous distributed computer systems. In this paper we propose effective destination decision policies using dynamic criteria such as mean job response time of node and estimated response time of job instead of fixed threshold for dynamic load balancing. We also show that the proposed policies produce very interesting results in heterogeneous distributed computer systems with star topology.


Assessing the achievement of Indonesian government institutions in implementing e-government has been conducted since around a decade ago. Several national assessments are available with almost the same ranking results. There is an agreement that the ultimate goal of e-government implementation is to achieve good government governance (GGG), while success stories of e-government require good governance practices. This study explored the correlation between e-government achievement and GGG achievement in Indonesia. Spearman's rank correlation was used to characterize the relationship strength between e-government assessment results and good governance assessment results. The data were collected from institutions that participated in e-government and good governance assessments. The results showed that the correlation between these two entities is not very strong. Most cases showed that e-government implementation and the achievement of good governance have only a moderate positive correlation and none of the studied cases indicated a significant connection. This result can be attributed to the lack of emphasis on goals achievement in the assessments. Thus, it is recommended that future Indonesian e-government assessments should involve impact indicators.


BACKGROUND AND OBJECTIVES
As root filled teeth often have insufficient coronal tooth structure, placement of a post is occasionally necessary to provide adequate retention for the core and final restoration. The aim of the present study was to investigate (i) the impact of post fit (form-congruence) and (ii) the influence of post length on the fracture resistance of severely damaged root filled extracted teeth.

MATERIALS AND METHODS
Forty single-rooted human teeth were root filled and divided into four groups (n = 10 per group). Post spaces were prepared with a depth of 6 mm (groups 1, 3) and 3 mm (groups 2, 4). Form-congruence with a maximal fit of the post within the root canal space was obtained in groups 1 and 2, whereas there was no form-congruence in groups 3 and 4. In all groups, glass fiber reinforced composite (FRC) posts were adhesively cemented and direct composite crown buildups were fabricated without a ferrule. Specimens were subjected to thermocycling and cyclic loading followed by application of static load until failure. Loads-to-failure [in N] were compared among the groups.

RESULTS
Post fit did not have a significant influence on fracture resistance, irrespective of the post length. Both groups with post insertion depths of 6 mm resulted in significantly higher mean failure loads (group 1: 274.27 N; group 3: 277.16 N) than the groups with post space preparation of 3 mm (group 2: 250.40 N; group 4: 255.48 N).

INTERPRETATION AND CONCLUSION
Within the limitations of this study, the fracture resistance of teeth restored with FRC posts and direct resin composite crowns without ferrules was not influenced by post fit within the root canal. These results imply that excessive post space preparation aimed at producing an optimal circumferential post fit is not required to improve fracture resistance of roots.


Software evolution is the process of developing, maintaining, and updating software systems. It is known that the software systems tend to increase their complexity and size over their evolution to meet the demands required by the users. Due to this fact, researchers have increasingly carried out studies on software evolution to understand the systems' evolution pattern and propose techniques to overcome inherent problems in software evolution. Many of these works collect data but do not make them publicly available. Many datasets on software evolution are outdated, and/or are small, and some of them do not provide time series from software metrics. We propose an extensive software evolution dataset with temporal information about open-source Java systems. To build this dataset, we proposed a methodology of four steps: selecting the systems using a criterion, extracting and measuring their releases, and generating their time series. Our dataset contains time series of 46 software metrics extracted from 46 open-source Java systems, and we make it publicly available.


Aims. Although from a theoretical point of view magnetic fields are believed to play a significant role during the early stages of star formation, especially during the main accretion phase, the magnetic field strength and topology is poorly constrained in the youngest accreting Class 0 protostars that lead to the formation of solar-type stars.
 Methods. We carried out observations of the polarized dust continuum emission with the SMA interferometer at 0.87 mm to probe the structure of the magnetic field in a sample of 12 low-mass Class 0 envelopes in nearby clouds, including both single protostars and multiple systems. Our SMA observations probed the envelope emission at scales ~600 − 5000 au with a spatial resolution ranging from 600 to 1500 au depending on the source distance.
 Results. We report the detection of linearly polarized dust continuum emission in all of our targets with average polarization fractions ranging from 2% to 10% in these protostellar envelopes. The polarization fraction decreases with the continuum flux density, which translates into a decrease with the H2 column density within an individual envelope. Our analysis show that the envelope-scale magnetic field is preferentially observed either aligned or perpendicular to the outflow direction. Interestingly, our results suggest for the first time a relation between the orientation of the magnetic field and the rotational energy of envelopes, with a larger occurrence of misalignment in sources in which strong rotational motions are detected at hundreds to thousands of au scales. We also show that the best agreement between the magnetic field and outflow orientation is found in sources showing no small-scale multiplicity and no large disks at ~100 au scales.


This article explores how a nonreductionist account of Nietzsche's influence on Michel Foucault can enrich our understanding of key concepts in singular works of both philosophers. I assess this exegetical strategy by looking at the two dichotomies Apollinian/Dionysian and ars erotica/scientia sexualis in The Birth of Tragedy and volume 1 of The History of Sexuality, respectively. After exploring the relation between these two dichotomies, I link the science of sexuality to the Apollinian art instinct via the existence of Socratic culture and argue against the "pleasure of analysis" as a sublated form of (Dionysian) ars erotica. These considerations lead to the notions of history in Nietzsche's and Foucault's philosophies that result in situating the polyvalent Ursprung of Greek tragedy and the descent of ars erotica and scientia sexualis in an antimetaphysical and nonteleological picture of historical development.


We report on the observation of quantum-limited timing jitter in a harmonically mode-locked soliton fiber laser with an ultralow-noise local oscillator. The effects of amplitude and phase modulation on the spectrum are described and compared with theory.


Coffee is an important cash crop for smallholder farmers and provides more than 80% of hard currency in Burundi. To highlight coffee growing conditions, agronomic practices and coffee yield, a survey was carried out in Buyenzi, Kirimiro and Mumirwa natural regions of Burundi in 2008. Data on coffee yield, age after planting or after rejuvenation and agricultural practices were collected through interview with coffee growers. Soil and coffee leaves were sampled for laboratory analysis. Results showed high variation of yield between two consecutive years particularly in Kirimiro and Buyenzi. Coffee trees age was high with over 70% of them aged more than 20 years. Mineral fertilizers were regularly applied by less than 7% of coffee growers and mulch was applied by more than 70%. N and Zn deficiency was observed in Kirimiro and Mumirwa while K excess was observed in all natural regions. Coffee was intercropped with various crops in the following descending order: Taro > beans > banana > maize. Agricultural techniques recommended in coffee cultivation were not properly followed, leading to a biennial variation and low yield.


This paper presents the research framework of an on-going study on the dairy sector on La Reunion. This Indian Ocean island is one of the French overseas departments. However, it struggles with similar problems as the developing areas in its neighbourhood, high levels of unemployment especially being a major concern. The agricultural sector therefore justifies the state support it receives by indicating the creation of employment and economic activity. Our focus is on the dairy sector on the Island, which is relatively recent and highly organized. Local milk production has increased over the years, yet farmers are aware of future policy reforms that should liberalize the sector. The outcome for the sector is a major concern. Our research question is to what extent milk production is sustainable on La Reunion, including the question of a future without governmental subsidies. The aim of this paper is to discuss a conceptual framework, relevant research questions and methodology to answer these research questions.


BACKGROUND
Investigation in health care services by data bases (DB) is undergoing an important increase in numerous countries. Several of the most relevant epidemiologic studies on the postsurgical morbidity and mortality of benign hypertrophy of the prostate (BHP) have used DB. The aim of this study was to prepare and optimize the DB of a health cooperative (Asistencia Sanitaria Colegial).

METHODS
Since 1981 the DB contains sociodemographic variables, data concerning visits to general practitioners and specialists, complementary examinations and hospitalizations. The coding system was specifically developed by the cooperative. The study base was made up of all the policies of the members between January 1981 and December 1988 (101,400 males). To identify the policies 14 codes potentially related with BHP were initially chosen and all the policies containing any of these codes were selected, with the manual analysis of 204 policies being thereby performed.

RESULTS
The total number of policies initially selected for the study was 3,157. Manual revision discarded the use of 9 of the 14 codes used in the first selection. In agreement with the 5 codes able to define diseases of prostatic gland and to the file in which they appeared the policies were classified as probable diseases of prostatic gland (n = 1,007, 31.9%), possible (n = 805, 25.5%) and improbable (n = 1,345, 42.5%). Likewise, the strategy to follow for the selection of a cohort of BHP cases was defined.

CONCLUSIONS
The manual analysis of policies evidenced a remarkable coherence and exhaustiveness of the information registered. The principal difficulties found with the data base used were the lack of a sole diagnosis and the coding system used in addition to the impossibility of automatically controlling the assistance received by the patients outside the cooperative system. The availability of a data base such as that herein described with a well defined large population and with accessible sociodemographic and health care information justifies collaborative efforts among health care administrators, clinicians, computer scientists and epidemiologists.


After more than four decades of research and almost 100 attachment studies, the mechanisms of intergenerational transmission of attachment still remain unclear. To better understand the mechanisms moderating the associations of attachment orientations from one generation to the next, this empirical study examined the roles of 1) shared and non-shared environmental factors that characterize critical events in adulthood such as career choice, income and child care; 2) gender differences in attachment between parents (Generation 1, G1) and their adult offspring (Generation 2, G2) and their possible interactions. A sample of 321 families with G2 adults aged 18 and over and two G1 parents up to the age of 81 took part in this study. Both generations completed the Experiences in Close Relationships attachment measure as well as a comprehensive detailed measure of current core characteristics in adulthood (e.g. employment status, income, whether they had children) and demographic variables (gender, age). The findings suggest that the associations between the attachment orientations of G1 and the attachment orientations of G2 were moderated by G2's income, their G1 paternal income and employment status, whether G2 had children (G3) of their own, and their family status after controlling for the age of G2, and the age of both paternal and maternal G1. When the associations for both paternal and maternal G1attachment orientation with both their male and female G2 was analyzed separately, this accounted for 35% of the variance of males' G2 attachment orientation. The discussion focuses on the contribution of these findings to attachment theory and draws clinical conclusions.


There has been increasing interest over the last few decades in the study of the effective content of Mathematics. One field whose effective content has been the subject of a large body of work, dating back at least to the early 1960s, is model theory. (A valuable reference is the handbook [7]. In particular, the introduction and the articles by Ershov and Goncharov and by Harizanov give useful overviews, while the articles by Ash and by Goncharov cover material related to the topic of this communication.) Several different notions of effectiveness of model-theoretic structures have been investigated. This communication is concerned with computable structures, that is, structures with computable domains whose constants, functions, and relations are uniformly computable. In model theory, we identify isomorphic structures. From the point of view of computable model theory, however, two isomorphic structures might be very different. For example, under the standard ordering of ω the success or relation is computable, but it is not hard to construct a computable linear ordering of type ω in which the successor relation is not computable. In fact, for every computably enumerable (c. e.) degree a, we can construct a computable linear ordering of type ω in which the successor relation has degree a. It is also possible to build two isomorphic computable groups, only one of which has a computable center, or two isomorphic Boolean algebras, only one of which has a computable set of atoms. Thus, for the purposes of computable model theory, studying structures up to isomorphism is not enough.


The primary goal of neuroeconomics is to explore the cognitive and neural basis of economic decision-making. With the development of brain imaging technology, there are more advanced techniques used to explore the mechanism of economic decision-making. As an important branch of economic decision-making, inter-temporal choice can provide new insight into the economic decision-making. In this review, we first summarized the neural mechanisms of inter-temporal choices and the four theories of the intertemporal choice, including single-system valuation theory, dual-system valuation theory, self-control theory and self-referential processing theory. Then, we reviewed the evidences for inter-temporal choice from recent brain lesion studies. In addition, the neural basis of inter-temporal choice uncovered by VBM-based and DTI-based studies were reviewed and discussed in detail. The frontal gray matter and white matter volume played a large role in the impulsivity of decision-making. The dorsolateral prefrontal-striatal white matter fibers also influenced the impulsivity of decision-making. Finally, we addressed the limitations in current studies and future research direction including research methods, cognitive processes, decision impulsivity and assessment models.


The push-off test for measuring the bonding property between surfacing layers and steel base metal was developed after referring to and analysing relevant literature. The push-off test specimens were prepared with surface layers of austenite steel, alloyed steel strengthened by niobium carbide, and high-chromium, hyper-eutectic alloyed, cast iron on a 45 steel base metal by applying a consumable metal electrode arc surfacing welding process with three types of self-shielding, flux-cored, welding wires. The chemical compositions and microstructure of the final product were studied. The bonding strengths of 316, 241, and 60 MPa between three types of surfacing layers and the 45 steel base metal were obtained, after the push-off test. Additionally, the fracture path and fractograph characteristics were observed and determined.


We have previously demonstrated that feeding chickens a diet containing high levels of the n-3 PUFA α-linolenic acid (ALA) significantly increases the content of the principal omega-3 long-chain polyunsaturated fatty acids, eicosapentaenoic acid and docosahexaenoic acid, in their meat and eggs. However, the effect of the diet on production characteristics of the birds has not been assessed. This study aimed to determine the effect of feeding male and female Cobb 500 broilers (n = 3840) a high ALA diet (containing 2.5% flaxseed oil) compared with a standard commercial Control diet (containing 2.5% tallow) on growth, feed conversion ratio and mortality until 6 weeks of age. As expected the dietary flaxseed oil significantly increased breast meat levels of omega-3 polyunsaturated fatty acids (~4-fold), with most eicosapentaenoic acid and docosahexaenoic acid being deposited in the phospholipid fraction. Both male and female birds fed the high ALA diet were significantly heavier at 6 weeks of age (77 g heavier in females, 87 g heavier in males). They also had a significantly (10%) lower feed conversion ratio, and a mortality rate that was not different from the Control diet across the 6-week feeding period. These findings indicate that a high ALA diet has the potential to enrich chicken breast meat with eicosapentaenoic acid and docosahexaenoic acid without loss of growth rate or feed efficiency, or increase in fat content of breast meat.


The Camp Swift lignite area was studied to describe the hydrogeology and to provide baseline data of the ground-water and surface-water resources that could be affected by the strip mining of lignite. The investigation was centered on the 18-square mile Camp Swift Military Reservation where a reported 80 to 100 million short tons of commercially mineable lignite occurs within 200 feet of the land surface. Monthly ground-water levels from a network of 22 wells showed that water levels in wells in the Hooper, Simsboro, and Calvert Bluff Formations of the Wilcox Group had slight and generally insignificant waterlevel changes from May 1980 to May 1981. The water quality in the Calvert Bluff Formation, which contains the lignite, and in the Simsboro Formation, which is the major aquifer beneath the Calvert Bluff, generally is satisfactory for most uses. Hydraulic pressures in the Calvert Bluff are greater than in the Simsboro, and this pressure differential results in the potential for downward movement of water from the Calvert Bluff to the Simsboro. However, confining beds of lignite, clay, silt, and other fine-grained material at and near the base of the Calvert Bluff greatly retard this interformational movement of water but do not totally prevent downward leakage. Data were collected from four streamflow stations and five automated rain gages to appraise the quantity and quality of the surface-water resources. Big Sandy Creek, which crosses Camp Swift, generally has a base flow of less than 0.5 cubic feet per second and infrequently is dry. Dogwood Creek, which originates on Camp Swift, normally is dry. The flow of both streams changes rapidly in response to rainfall in the watersheds. The quality of the water in both streams generally is suitable for most uses, but varies significantly in response to variations in discharge and related factors. Alithologic examination of 255 feet of cored section that represents the overburden and the included lignite showed cyclic layering of fine sand, silt, clay, and lignite. Chemical analyses of the core were performed to determine the contents of major inorganic and trace constituents. These analyses indicate that the content of pyritic sulfur generally is small but variable.


Chiller water plant systems have been found to operate at a lower efficiency during part load conditions in tropical countries like Malaysia. The inefficient performance of the chillers results in an increase in the system energy consumption that ultimately affects the electrical demand of a particular building. This paper analyzes and identifies optimization strategies that provides the greatest impact on increasing the efficiency at part load conditions of specifically air-cooled chiller plant systems. The research focuses on the application of variable speed drives (VSD) on system components of a centralized centrifugal chiller compressor system at part load conditions where the system energy usage and coefficient of performance are compared to that of a conventional chiller system. A semi-empirical model of both the chiller plant system performance and the results obtained are compared to identify the effectiveness of the optimization strategy. A cooling load profile of a typical building is used to evaluate the potential energy savings following the increase in chiller COP and efficiency. It was found that the total annual energy consumed by the constant flowrate chiller and VSD integrated chiller is 20.71 GW and 14.75 GW respectively, hence a 28.7% reduction in energy usage is observed with the implementation of the optimization strategy. Based on the results of both the models, the integration of the VSD allows the COP of the chiller plant to increase. An increase in energy savings and reduction in emissions is seen when the speeds of the chilled water pump, compressor, and condenser pump are adjusted to meet current load conditions. The results of this study will be a benchmark for designers and engineers in an effort to further improve the performance of chiller plant systems.


Three challenges of political nature were identified in 2022: increasing number of institutions in many countries in Asia to require journal article publication for graduation of an academic degree, changes in Journal Citation Index (JCITM) policy, and a retraction case in Journal of Cross-Cultural Psychology. As a response to these challenges, Makara Human Behavior Studies in Asia made several changes. First, we now publish incrementally to accommodate the requirement to publish in time. In Indonesia, as well as in many parts of Asia, publications in journals are increasingly used to satisfy administrative requirements. We have received requests for faster publication due to graduation requirements from authors from Indonesia, Malaysia, and Pakistan. The importance of journal publication is increasing in the region. Second, the everchanging scientific landscape triggers a response from Clarivate Analytics that decided to include Journal Impact Factor (JIFTM) in the subsequent publication of the Journal Citation Reports (JCRTM) in 2023.


A two-dimensional speckle tracking system was used to measure volumetric flow rates in a free laminar jet in vitro. The system utilized the Sum-Absolute-Difference (SAD) pattern matching algorithm to track small speckle regions between successive pulse-echo acquisitions in order to determine 2D velocities. Velocity profiles were measured across the jet diameter at a transducer angle of 90° at six flow rates from 2-12 cm/s. The profiles were then integrated, assuming a circular cross-section, to compute the volumetric flow rates. Experimental volumetric flow rates exhibited excellent agreement with actual rates (best fit line: y=1.04x-0.043, R2>0.99), with a mean error of 3.5%. Results indicate that accurate volume flow estimates can he obtained at 90°, where current uni-dimensional Doppler instruments fail, in circular free laminar jets


Behavior of composite beams with headed stud shear connectors subjected to monotonous and displacement controlled non-reversible repeated loadings has been evaluated through studying influences of the cross-sectional proportioning, the degree of partial interaction, and the level of ductile deformability in the post-yielding stage, in addition to the state of loading (whether monotonous or repeated). Eleven one- third scaled composite beams (with their push-out segments) were manufactured and tested in five pairs (each comprising the two loading cases representing one varying studied parameter) beside the single standard composite beam dedicated to verify accuracy of the test results by comparing them to the prototype ones (three authorized experimental and analytical investigations) where no distinction (other than 7 % difference) between the results of the three authorized refereed investigations (experimental, analytical and Eurocode) and the present one.Regarding the flexural resistance in repeatedly loaded composite beams, it has been found that lowering the neutral axis (by adding bottom steel plate) has significantly increased the beam flexural resistance by an average of 24.7 %. Meanwhile, the intensity of headed studs distribution in stiffened repeatedly loaded composite beams has revealed a vital role in controlling the severity of the post-ultimate flexural weakening, where decreasing number of the headed studs to the half has increased the value of that unfavorite parameter by 160.58%. Furthermore, that specified decrease of headed stud intensity has lowered the advantageous residual cyclic flexural ductility by 19.37 % and 11.48 % without and with stiffening bottom steel plates, respectively. Regarding the effect of the lengthening the headed stud on behaviour of the repeatedly loaded composite beams it has been found that lengthening the medium-length headed studs by 72% has raised the flexural stiffness by 41.1 %, while it has decreased the residual cyclic slippage index by 54.3 %.


Information on the Leadership and Management of Humanitarian Action course for the graduate program of the Institute of International Humanitarian Affairs


We report on the generation of tunable infrared picosecond pulses by a short-cavity dye laser system consisting of a short cavity, a three-stage amplifier, and a wavelength control unit. The laser emission is temporally, spectrally, and spatially resolved. The conditions for optimum performance are ascertained, and the output characteristics important to experimental applications are determined.


Neonatal diseases are among the main causes of morbidity and a significant contributor to underfive mortality in the world. There is an increase in understanding of the pathophysiology of the diseases and the implementation of different strategies to minimize their burden. However, improvements in outcomes are not adequate. Limited success is due to different factors, including the similarity of symptoms, which can lead to misdiagnosis, and the inability to detect early for timely intervention. In resource-limited countries like Ethiopia, the challenge is more severe. Low access to diagnosis and treatment due to the inadequacy of neonatal health professionals is one of the shortcomings. Due to the shortage of medical facilities, many neonatal health professionals are forced to decide the type of disease only based on interviews. They may not have a complete picture of all variables that have a contributing effect on neonatal disease from the interview. This can make the diagnosis inconclusive and may lead to a misdiagnosis. Machine learning has great potential for early prediction if relevant historical data is available. We have applied a classification stacking model for the following four main neonatal diseases: sepsis, birth asphyxia, necrotizing enter colitis (NEC), and respiratory distress syndrome. These diseases account for 75% of neonatal deaths. The dataset has been obtained from the Asella Comprehensive Hospital. It has been collected between 2018 and 2021. The developed stacking model was compared to three related machine-learning models XGBoost (XGB), Random Forest (RF), and Support Vector Machine (SVM). The proposed stacking model outperformed the other models, with an accuracy of 97.04%. We believe that this will contribute to the early detection and accurate diagnosis of neonatal diseases, especially for resource-limited health facilities.


Background: Gallbladder infections are one of the most important problems that affect Sudanese patients. Objectives: To isolate bacterial species from infected human gallbladder's bile in Sudanese patients admitted for cholecystectomy due to calcoulus or acalcoulus cholecystitis. Materials and Methods: A total of 100 bile specimens from 100 patients (88 females and 12 males), were examined in this study. Bile specimens were collected from three different operating theatres including IbnSena Hospital, Sudan Private Clinic and Omdurman Teaching Hospital. Results: Six bacterial species were recognized in bile specimens, four of them are gramnegative and two are gram- positive species. In the present study, bacteria were isolated from 40 specimens out of the 100 bile specimens cultured with an overall incidence of 40%. It was noted that all positive bacterial bile cultures correlated with the presence of gallstones except three Salmonellae which were isolated from bile of acalculus gallbladders. The most prevalent bacteria isolated were E.coli which was isolated from 24 specimens out of the 100 bile specimens. On the other hand, Staphylococcus aureus and Pseudomonas spp. were less frequently isolated from bile specimens showing frequencies of 4 (4%) for each. Conclusion: The finding of this study indicated that Escherichia coli were the most prevalent bacteria which isolated from human bile. As well as, the study revealed that certain bacterial species such as Salmonellae possess characters which allow them to cause cholecystitis without need to gallstones formation. Key words: Gallbladder Bile, Bacterial isolates, Bile specimens, Cholecystectomy; Bacterial cholecystitis, Acalculus gallbladders.


Autophagy--a process of "self-eating" that involves enzymatic digestion and recycling of cellular constituents in response to stress--contributes to both cancer cell death and survival. In this issue of the JCI, Lu et al. report that controlled induction of tumor suppressor gene aplasia Ras homolog member I (ARHI) results in autophagic cell death of human ovarian cancer cells in vitro (see the related article beginning on page 3917). However, within xenograft tumors in mice, multiple factors within the tumor microenvironment switched ARHI-induced autophagy to a mechanism of tumor cell survival, leading to tumor dormancy. Since ARHI expression is suppressed in the majority of breast and ovarian cancers but is high in premalignant lesions, ARHI-induced autophagy could be manipulated for therapeutic benefit.


ABSTRACT Background The aim was to investigate the association of injuries with male football player continuity, progression and chances of reaching the First team in an elite academy. Methods Injuries and exposure time were prospectively recorded, following the FIFA guidelines, over 6 seasons (2011–2017) in Under (U)12, U14, U16, U19, 2nd/3rd team and First team players from the same professional football club. Results U19 and 2nd/3rd team players progressing to the next level had a lower injury burden and higher match availability compared to players that did not progress. Injury burden was lower in players progressing from U12 to U14. All players progressing from the 2nd/3rd teams to the First team had a match availability higher than 84% and did not suffer an anterior cruciate ligament (ACL) rupture or an injury requiring over 200 (+200) days to return to play. In U19 and 2nd/3rd team players, injuries requiring +100 and +200 days to return to play, ACL ruptures and groin pain, but not hamstring and ankle ligament injuries, were associated with lower odds of continuing in the academy each season. Conclusion Injuries were negatively associated with player progression, and injury prevention and return-to-play strategies should be a priority for football academies.


Reaction of bauxite residue with seawater results in neutralization of alkalinity through precipitation of Mg-, Ca-, and Al-hydroxide and carbonate minerals. In batch studies, the initial pH neutralization reaction was rapid (<5 min), with further reaction continuing to reduce pH for several weeks. Reaction with seawater produced a residue pH of 8 to 8.5. Laboratory leaching column studies were undertaken to provide information on seawater neutralization of the coarse-textured fraction of the waste, residue sand (RS), under conditions comparable with those that might be applied in the field. An 0.80-m-deep column of RS was neutralized by the application of the equivalent of 2-m depth of seawater. In addition to lowering the pH and Na content of the residue, seawater neutralization resulted in the addition of substantial amounts of the plant nutrients Ca, Mg, and K to the profile. Similar results were also obtained from a field-scale assessment of neutralization. However, the accumulation of precipitate, consisting of hydrotalcite, aragonite, and pyroaurite, in the drainage system may preclude the use of in situ seawater neutralization as a routine rehabilitation practice. Following seawater neutralization, RS remains too saline to support plant growth and would require fresh water leaching before revegetation.


Analysis of the economic feasibility of using a multi-species grazing program to control leafy spurge was based on adding a sheep enterprise to an existing ranch or leasing sheep during the grazing season. Several sheep enterprise budgets were developed for different flock size, performance, and financial characteristics. Fencing expenses were estimated for adding wire to an existing fence or for constructing new fence. Treatment costs included fencing expenses and net returns from a sheep enterprise (which could be positive or negative) or expenses from leasing sheep. Returns from control included recouping lost grazing outputs (for cattle) from within the infestation and maintaining existing grazing capacity by preventing current infestations from expanding. Rangeland with 0.2 to 0.8 AUMs/acre stocking rates was evaluated. When flock performance (e.g., lambing rate, weaning weight) was equal to that of established sheep producers (best case scenario) over a ten-year period, treatment benefits greatly exceeded costs in all situations. When flock performance was equal to that of unassisted lambing flocks (worst case scenario), treatment benefits generally exceeded costs only on more productive rangeland (0.7 AUMs/acre or greater). However, in most of those situations, a multi-species grazing program resulted in less economic loss than not controlling the infestation. The majority of ranchers adopting a sheep enterprise will likely be somewhere in between these two scenarios. A lease rate of $1 per head per month was economical in many of the control situations, but lease rates of $2 per head per month would not be recommended. Probably the biggest factor influencing the economics of control was enterprise returns. Since numerous factors can affect the net returns for a sheep enterprise, a careful evaluation using siteand rancher-specific inputs would be recommended before implementing sheep grazing as a leafy spurge control method.


In recent times the social dimension of patients with acquired brain dysfunctions functioning has become an important area of interest for neuroscientists and clinical neuropsychologists. Empirical analyses using different methods reveal the role of the right hemisphere in many processes responsible for interpersonal behavior. The study was designed to assess the state of social cognition and its hypothetical compounds with observable social behavior. A group of patients with ischemic right hemisphere dysfunction and comparison groups took part in it. The results point to disturbances of various forms of social cognition in patients with right hemisphere damage, and also confi rmed the presence of signifi cant correlations between social cognition and behavior. The possibilities for applying the results were also discussed.


Heavy metal ions are commonly occurring as toxic metals in natural ecosystems due to the effluent of electroplating, electronic, tanning industries and etc. (1,2). These ions are assimilated, stored, and concentrated by organisms that are exposed to them (3,4). In aquatic environments, one common pollutant metal ion is chromium that usually appears as Cr(VI) and Cr(III) (5). Though Cr(VI) has high A-R-T-I-C-L-EI-N-F-O A-B-S-T-R-A-C-T Article Notes: Received: Jan12, 2018 Received in revised form: Apr 23, 2018 Accepted: Apr 28, 2018 Available Online: May 1, 2018 Background & Aims of the Study: Chromium is widely detected in surface waters and underground waters, which usually appear as Cr(VI), and Cr(III), at sites associated with industrial activities. Cr(VI), in effluent streams with a high level of mobility and notorious mutagenic and carcinogenic toxicity; thus Cr(III) does not have much mobility in soil. So, converting it into less harmful species could be beneficial. Materials & Methods: Cr(VI) photocatalytic reduction in aqueous media was analyzed using desperately low dosages of nanoparticles of commercial titania. A directly imposed irradiation photoreactor equipped with a supersonic source was applied. The optimization of the reduction process was done using the central composite design (CCD) experimental. The residual concentration of Cr(VI) ion was determined by colorimetrically method. In addition, the impact of other factors, including water matrix and hole scavengers, also reduction kinetics were studied. Results: A quadratic equation for reduction efficiency was proposed, and the adequacy of it was evaluated by a variety of statistical methods. A maximum of 80.6% reduction in aqueous samples containing an initial concentration of Cr(VI) within the investigated optimum operating condition (TiO2 dose of 33 mg/L; pH of 2.5, T=35 °C and t=120 min) was obtained. Results indicate that UV irradiation alone is an acceptable method for Cr(VI) reduction maybe due to H2O2 photolytic generation. The results show Cr(VI) photoreduction was greatly enhanced by about 88.2% when NO3 − was used in comparison with SO4 2− anion. The photoreduction enhancements with the scavengers are appeared in the following order ethylene glycol > formic acid > citric acid with relevant. Maximum reduction of 96.5% for Cr(VI) was obtained in the presence of ethylene glycol hole scavenger. The results indicated that the process rate can be presented with a pseudo-first-order kinetic model. Conclusion: The results showed, the CCD design was approximately adequate in Cr(VI) reduction, so it can be a suitable option for water quality improvement. The addition of inorganic or organic species can act as scavenging hydroxyl radicalswhich are photo-generatedand valanceband holes that are on the photocatalysts of the semiconductor, and consistently, enhance the photocatalytic reduction of Cr(VI) ion.


Background/Aims Digital single-operator cholangioscopy (DSOC)-guided mapping biopsy (DMB) and tube-assisted mapping biopsy (TMB) are two techniques used for preoperative evaluation of biliary tract cancer (BTC). However, data regarding the diagnostic performance of these techniques are limited. Methods We retrospectively examined consecutive patients with BTC who underwent either technique at our institution between 2018 and 2020. We evaluated the technical success rate, adequate tissue acquisition rate, and diagnostic performance of these techniques for the evaluation of lateral spread of BTC. Results A total of 54 patients were included in the study. The technical success rate of reaching the target sites was 95% for DMB and 100% for TMB. The adequate tissue acquisition rate was 61% for DMB and 69% for TMB. The adequate tissue acquisition rate was low, especially for target sites beyond the secondary biliary radicles. The sensitivity of DMB alone was 39%, which improved to 65% when combined with visual impression. Experts demonstrated a higher negative predictive value and diagnostic accuracy with respect to both DSOC visual impression and DMB for the evaluation of lateral spread of BTC compared to trainees. Conclusions Adequate tissue acquisition rates were similar between the two techniques. Since DMB requires expertise, TMB may be an acceptable option when DSOC is unavailable or when DSOC expertise is limited.


Purpose

The current research explored both pre-purchase and post-purchase factors of consumer behaviour. Specifically, the purpose of this paper is to investigate the relationships that may exist among consumers' perceptions of perishability, scarcity, low price, attitudes, impulse buying, post-purchase emotions, and product returns within the context of the fast fashion environments.

Design/methodology/approach

A total of 246 usable questionnaires completed by female undergraduate students, who made purchases and product returns at fast fashion retailers, were analysed in SPSS and AMOS 23.0. Structural equation modelling was employed to test the hypotheses.

Findings

Consumers who are attracted to scarcity due to limited supply and scarcity due to time, referred to as perceived perishability, have a positive attitude towards the fast fashion retailers in which products are presented in scarce environments. Likewise, consumers have a positive attitude towards fast fashion retailers due to low priced merchandises they offer. Consequently, consumers who have a positive attitude towards the fast fashion retailers are likely to purchase products from them impulsively. Moreover, impulse buying behaviour positively influenced some negative post-purchase emotional responses, which in turn positively influenced product returns in the fast fashion environments.

Research limitations/implications

The results of the current study contribute to a greater understanding of apparel-related consumer behaviour in general. A theory formation of fast fashion consumer behaviour from acquisition to disposal can be drawn from the results of this study. Because some fast fashion retailers do sell clothing for both men and women, researchers could compare the responses of males and females to examine differences in consumer behaviour related to demographic characteristics. In the future, an examination of actual emotional responses and return behaviour would be beneficial for a more complete understanding of post-purchase consumer behaviour.

Practical implications

Fast fashion retailers could use this information to carefully design shopping environments that induce impulse buying behaviour because it may result in product returns. Fast fashion retailers need to understand the causes of the return behaviour, whether consumer related or product related, to better meet the needs of their target market. Return policies must be considered.

Originality/value

This research is the first to examine the impact of negative emotions following consumers' impulse buying on product returns in the fast fashion retail environments.


FP-Growth algorithm is an association rule mining algorithm based on frequent pattern tree (FP-Tree), which doesn't need to generate a large number of candidate sets. However, constructing FP-Tree requires two scansof the original transaction database and the recursive mining of FP-Tree to generate frequent itemsets. In addition, the algorithm can't work effectively when the dataset is dense. To solve the problems of large memory usage and low time-effectiveness of data mining in this algorithm, this paper proposes an improved algorithm based on adjacency table using a hash table to store adjacency table, which considerably saves the finding time. The experimental results show that the improved algorithm has good performance especially for mining frequent itemsets in dense data sets.


Polyethylene glycols (PEG) are agroup of polymers with different mo-lecular weights (from 200 to 6000)and melting points depending on thedegree of polymerisation.They arewater-soluble and easily mixed withmost organic solvents;they are chemi-cally inert and do not dissolve lipidsand glycogen. Low molecular weight PEG beinga colourless,smell-less,and viscous fluidcan be mixed with water and Epoxyresin at room-temperature.It isconvenient to operate.The present work describes the use of PEG400 made in China as a dehydrationfluid in ultra-thin sectioning.Thepreservation of cellular ultrastruc-ture was found to be satisfactory. Kidney of mouse and gastrula ofCynops orientalis were cut into smallpieces and prefixed in 2.5% glutaral-dehyde buffered with 0.1 M sodiumcacodylate pH 7.4 for 1.5 hrs.Af-ter washing with 0.1 M sodium cacodylate buffer pH 7.4 about 3 hrsthe tissues were postfixed in 2% osmicacid for 1 hr.After washing thetissues were dehydrated with increasing grades of PEG 400 solution (from50% to 100%),3—6 hrs for eachgrade.The tissues were then infiltrated with fresh Epon 812 mixtureat room temperature for 48 hrs.Withthe aid of agitator the dehydrationand infiltration should be accomplished thoroughly.Polymerization wascarried out at 60℃ for 48 hrs. The micrographs showed that theultrastructure had been well preser-ved.Crystal lattices of yolk plateletsof gastrula cells of Cynops orientalis andsome small vesicles in the peripheralzone of the yolk were distinctly shownjust as that prepared with the silyla-ted aminoplastic-water soluble embedding medium. According to the property of lowmolecular weight PEG,it could beexpected that this method would beuseful to the samples which should beavoided in contact with organic solvents such as alcohol and acetone.This method needs further investiga-tion.


Background More than 35 000 people in Serbia suffer from RA and more than a million suffer from some rheumatic or musculoskeletal disease. The Association of Rheumatic Diseases Patients of the Republic of Serbia (ORS) is a non-political, non-government and not-for-profit association of volunteers, aiming to: - provide information on prevention, symptoms, available treatments, rehabilitation options and resocialization to people suffering from rheumatic diseases so to better inform and improve the quality of life for people suffering from rheumatic diseases, and - raise social awareness and increase public understanding of the debilitating effects of rheumatic diseases. Every year our young association celebrates the 12th October - World Arthritis Day, as a central event in our activities calendar. In 2012, as part of the celebrations, we organized a fashion show. Objectives To explore and promote opportunities for designing clothes for people with rheumatic and musculoskeletal diseases. Through the visual effect of the fashion show, to bring general public closer to understanding the effects of rheumatic diseases. Methods The fashion show, themed "Move to Improve", was organized in cooperation with Belgrade Design District and Serbian Media, and was held during the 21st Maybelline Fashion selection manifestation. The models were volunteers - RMDs sufferers from ORS, who were escorted to the stage by journalists from First Serbian Television Station. The models wore clothes that had been specifically designed to suit people who cannot get dress themselves easily. Results Young designers did their job very well. They created simple, usable, modern clothes without small buttons, zippers, ribbons. The audience supported very kindly our brave models. The show attracted strong media attention, with reports from this event broadcast by 15 TV and 6 radio stations. Also, 17 printed media and 25 internet portals published stories about the show. Daily newspaper "Blic" organized a mini internet competition for the best fashion show during the whole fashion manifestation and more than 1.3 million visitors voted. With 62% of the votes, "Move to improve" won the prize for the best fashion show during a significant fashion manifestation in Serbia. Conclusions Our brave volunteers have shown that, in spite of their special needs, people with RMDs can and should follow and create fashion. They were seen and admired by very many people. The "Move to Improve" show is still talked about in Serbia – among ordinary people, health professionals and RMD sufferers … Disclosure of Interest None Declared


This paper deals with proprietary information and industrial espionage. To obtain this goal, an innovation-based growth model is constructed where R&D employment is split into two types of researchers: inventors and spies. The paper provides an analysis of the steady-state effects of better enforcement of proprietary information protection in terms of a change of the institutional set-up devoted to intellectual property rights and private information protection. We find that there is only a temporary positive impact on the innovation rate, while there is permanent negative effect on the steady-state rate of spying and nominal wage.


Rocks are natural materials used in a variety of coastal protection structures, especially in rubble mound breakwaters. Engineering properties of rocks, such as durability and resistance to degradation factors of the marine environments are important properties which construction material of marine structures should behave. Rock durability is a function of rock properties and condition of environment in which the rock will be used. Regarding the economical importance of constructed coastal ports and facilities in coast lines of south Iran, it is necessary to evaluate the engineering properties of rocky construction materials in such structures from durability and degradation point of view. In this study, by investigating and sampling the used rock material in 27 constructed rubble mound breakwaters along the 1000 km south Iran`s coastlines, from Amery Port in western part to Pasabandar Port in 85 km east Chabahar, and regarding the observations that collected in field visual investigations and engineering tests of durability examination, the experimental relationship between physical, mechanical and durability parameter of studied rocks have been concluded and consequently criterion to select the suitable rock of three groups of rocks limestone, igneous rock and bioclastic sedimentary rock (lomashell) have been presented individually.


Purpose: To evaluate the feasibility of targeted renal therapy (TRT) to decrease the rate of contrast-induced nephropathy (CIN) during endovascular aortic aneurysm repair (EVAR) in patients at risk for CIN. Methods: A prospective nonrandomized analysis of TRT was performed in 10 high-risk patients (8 men; median age 66.5 years, range 56–80) with pre-existing renal insufficiency. TRT involved high-dose intrarenal artery infusions of fenoldopam (FEN), a short acting selective dopamine-1 agonist and renal arteriolar vasodilator, delivered percutaneously via a left brachial access using the 5-F Benephit PV Infusion System during EVAR. Results: There were no device-related complications. TRT infusion duration ranged from 3.5 to 6.0 hours (median 4.5). Median contrast dosage was 120 mL (range 50–200). At 24 and 72 hours after EVAR, creatinine clearance (CrCl) had improved in 7 (70%) patients, remained unchanged in 2 (20%), and declined >25% in 1 (10%); the latter returned to baseline on day 5. At 30 days, 7 (70%) patients had improved CrCl and 3 (30%) remained unchanged. Conclusion: TRT is feasible during EVAR in high-risk patients. Further investigation is warranted to determine the safety and efficacy of TRT in preserving renal function during EVAR.


Learn the basics of Capital IQ, a powerful database used to find information and data on companies, markets and commodities.


N(5)-Carboxyaminoimidazole ribonucleotide synthetase (N(5)-CAIR synthetase), a key enzyme in microbial de novo purine biosynthesis, catalyzes the conversion of aminoimidazole ribonucleotide (AIR) to N(5)-CAIR. To date, this enzyme has been observed only in microorganisms, and thus, it represents an ideal target for antimicrobial drug development. Here we report the cloning, crystallization, and three-dimensional structural analysis of Aspergillus clavatus N(5)-CAIR synthetase solved in the presence of either Mg(2)ATP or MgADP and AIR. These structures, determined to 2.1 and 2.0 A, respectively, revealed that AIR binds in a pocket analogous to that observed for other ATP-grasp enzymes involved in purine metabolism. On the basis of these models, a site-directed mutagenesis study was subsequently conducted that focused on five amino acid residues located in the active site region of the enzyme. These investigations demonstrated that Asp 153 and Lys 353 play critical roles in catalysis without affecting substrate binding. All other mutations affected substrate binding and, in some instances, catalysis as well. Taken together, the structural and kinetic data presented here suggest a catalytic mechanism whereby Mg(2)ATP and bicarbonate first react to form the unstable intermediate carboxyphosphate. This intermediate subsequently decarboxylates to CO(2) and inorganic phosphate, and the amino group of AIR, through general base assistance by Asp 153, attacks CO(2) to form N(5)-CAIR.


A statistical theory of plasma turbulence which is composed of multiple-scale fluctuations is examined. Influences of statistical noise and variance of rapidly changing variable in an adiabatic approximation are investigated. It is confirmed that the contributions of noise and variance remain higher order corrections. Transition rate of the turbulence with multiple scale lengths is obtained under the refined adiabatic approximation.


BACKGROUND
Nested variant of urothelial carcinoma (NVUC) is a rare and often unrecognized urothelial neoplasia. Diagnosis is based on morphology only, and no immunohistochemical or cytogenetic differences from usual high-grade urothelial carcinomas have been reported.

CASE
We describe the case of a 49-year-old woman affected by hepatitis C virus presented with fever, discomfort, urgency, and hypertension. Computed tomography showed a sclerosing inflammatory process involving the connective and adipose tissue of the renal sinus. In the absence of renal or pelvic masses an underlying malignancy was excluded and renal abscess or tuberculosis was suspected. Accordingly, nephrectomy and proximal ureterectomy was performed. Grossly, calices, renal pelvis, and pyeloureteral junction appeared modestly dilated with whitish, thickened, and uneven mucosa. Microscopically, the subepithelial connective tissue, the fibromuscular layer, and the renal sinus fat were diffusely infiltrated by small nests of medium to large urothelial cells (p63 positive) with abundant eosinophylic cytoplasm and slightly atypical nuclei.

CONCLUSION
On the basis of morphologic and immunohistochemical features, a diagnosis of NVUC was made. After surgery, the patient recovered from hypertension. Pelvic and upper urothelial tract NVUCs are uncommon, and to the best of our knowledge, this is the second case of NVUC with renal involvement.


This study developed an enzymatic method for high‐throughput mapping of phosphoproteins on two‐dimensional (2‐D) polyacrylamide gels. Proteins of cultured rat skin fibroblasts were divided into two aliquots, one of which was dephosphorylated using recombinant lambda protein phosphatase and the other was not treated with the enzyme. The two aliquots were then subjected to 2‐D electrophoresis. Phosphoproteins could be mapped on the 2‐D gel of the nontreated aliquot by comparing the gels of the two aliquots, because the phosphoproteins in the treated aliquot shifted to more basic positions on the gel. This technique revealed that approximately 5% of the detectable proteins were phosphorylated. Fourteen phosphoproteins were identified by mass spectrometry, including proteasome component C8 and small glutamine‐rich tetratricopeptide repeat‐containing protein. Furthermore, the extent of phosphorylation of two actin modulating proteins, destrin and cofilin, was found to be significantly reduced when the cells were chemically or enzymatically detached from the culture dishes. The method developed by this study can generally be applied to all biological materials and is useful for high‐throughput mapping of phosphoproteins in proteome research.


Modern industries face increasing demands to improve the precision and workability of equipment, leading to stringent requirements for hydraulic servo systems in terms of flow, accuracy, and output power. High‐flow servo valves and multi‐valve synchronous control methods have seen more applications in the industry to meet these demands. However, high‐flow servo valves are expensive and have unsatisfactory performance, and synchronous control methods require servo valves to have the same hydraulic characteristics, resulting in higher cost and lower accuracy of high‐flow hydraulic servo systems. Also, very little has been conducted on controlling single actuators using multiple valves. In this study, we design a novel dual‐valve hydraulic servo system structure with a high‐flow proportional directional valve that is connected in parallel with a low‐flow servo valve and further develop the mathematical model of this dual‐valve system. Next, a harmonic control scheme was proposed, which included a flow allocation layer and trajectory tracking layer. Thereby, we achieved optimal control of two valves, and robust performance was guaranteed. Finally, we investigate the relationships between the flows of two valves, the deadband of the proportional directional valve, and trajectory tracking errors. Experimental results show that the proposed control scheme can effectively adjust the output flow of each valve dynamically according to the tracking trajectory and the hydraulic characteristics of the two valves, and the tracking performance of the servo system is significantly improved. This method is promised to enable the realization of an economical, high‐flow, high‐precision hydraulic servo system that can be generally used in various fields, such as marine engineering and construction.


Abstract Tapioca starch (TS) and poly(lactic acid) (PLA), in 90:10 weight ratio, were blended with 3% Cloisite 10A were and prepared by a twin screw extruder. Screw speed, screw configuration, die nozzle diameter and moisture content were varied to determine their effects on organoclay intercalation. Selected structural, thermal, physical and mechanical properties were characterized by X-ray diffraction, scanning electron microscopy, differential scanning calorimetry, and Instron universal testing machine. The first (X-ray) diffraction peak was observed to shift to a lower angle compared to that of pristine Cloisite 10A. The first diffraction peaks for the nanocomposites were narrow, indicating a strong intercalated behavior. These results were observed for all extrusion variables using mixing and compression screws, screw speeds of 100, 135 and 175 min–1; moisture contents of 14, 17 and 20%, and die nozzle diameters of 3 and 4 mm. These extrusion variables had significant effects on the structural, thermal, physical and mechanical properties, and glass transition and melting temperatures of TS/PLA/Cloisite 10A nanocomposite foams due to the intercalation of organoclay.


As a consequence of the intensification of environmental degradation, we observed a decrease in water availability and a change in water quality. Therefore, the integrated management of watersheds is an issue of extreme importance. Limnological monitoring is an important tool for environmental management, providing information on the quality of inland waters and indicating the main factors responsible for the degradation of water resources. The Barra Bonita reservoir is located in the central region of Sao Paulo State, in the Superior Middle Tiete Basin, and the adjacent areas of the reservoir are subject to several human activities potentially impacting the environment. In this context, there is a need to determine the nature of negative human impacts on water resources. The present study aimed to analyze and diagnose the water quality of Barra Bonita reservoir using the water quality index (WQI) and the trophic state index (TSI). To this end, measurements of specific limnological variables were made in situ and laboratory and an analysis of data from CETESB annual reports was conducted. The results found that the waters of the reservoir were relatively healthy, but hyper eutrophic for the period from2007 to 2012, indicating the importance of environmental management for the restoration and preservation of natural resources in this region. The estimated indices and the land use map of adjacent areas of the Barra Bonita reservoir showed that agriculture was the largest category of land use and that it contributes directly to the degradation of water quality due to contamination by run-off from fertilizers.


Declarative multimedia documents represent the description of multimedia applications in terms of media items and relationships among them. Relationships specify how media items are dynamically arranged in time and space during runtime. Although a declarative approach usually facilitates the authoring task, authors can still make mistakes due to incorrect use of language constructs or inconsistent or missing relationships in a document. In order to properly support multimedia application authoring, it is important to provide tools with validation capabilities. Document validation can indicate possible inconsistencies in a given document to an author so that it can be revised before deployment. Although very useful, multimedia validation tools are not often provided by authoring tools. This work proposes a multimedia validation approach that relies on a formal model called Simple Hypermedia Model (SHM). SHM is used for representing a document for the purpose of validation. An SHM document is validated using a hybrid approach based on two complementary techniques. The first one captures the document's spatio-temporal layout in terms of its state throughout its execution by means of a rewrite theory, and validation is performed through model-checking. The second one captures the document's layout in terms of intervals and event occurrences by means of Satisfiability Modulo Theories (SMT) formulas, and validation is performed through SMT solving. Due to different characteristics of both approaches, each validation technique complements the other in terms of expressiveness of SHM and tests to be checked. We briefly present validation tools that use our approach. They were evaluated with real NCL documents and by usability tests.


Communication and information technology are developing very rapidly at present. At the same time, the number of older drivers is increasing. When designing systems for elderly drivers, it has been shown that: (1) simplifying a task reduces performance differences between old and young; and (2) the optimization of onboard systems (better legibility and intelligibility of the information, simplified dialogue) in relation to the abilities of elderly drivers benefits the rest of the user population. Elderly people do not automatically reject new information and assistance technologies especially when the systems are user friendly. However, the ergonomics of these new technologies must be studied, with particular attention to the specific needs of the elderly, in order not to marginalize them


The investigated generic configuration consists of cylindrical film cooling holes with a diameter of D = 8.4 mm and an inclination angle of α = 35°. The jets are characterized by a momentum flux ratio of I = 0.63, a density ratio of DR = 0.94 and a cross-flow Reynolds number of Re = 5500. Stereoscopic PIV allows creating a (pseudo) three dimensional image of the flow field. High resolution PIV is used to evaluate velocity fluctuations. The numerical model uses the SST and an EARSM turbulence model. The turbulent scalar fluxes are computed by a constant turbulent Prandtl number as well as algebraic models for the turbulent heat flux. The presented results consist of field cuts and line profiles of the velocity, vorticity and turbulent kinetic energy. All considered numerical options can predict the velocity field accurately, the SST turbulence model is the numerically most stable model and has the lowest demands in computational costs.


This article explores the results of a rubric-based formative assessment of an eportfolio task as part of a pedagogical subject on a weekly basis during the first year in the Teacher Education programme of the University XXX. The study aims to explore the possibilities of the rubric usage for formative assessment as an answer to all student learning needs. The literature review briefly covers research on closely related concepts such as formative assessment and feedback along with process eportfolios for reflective tasks, which are all aimed at achieving higher-level cognitive skills and, eventually, self-regulated learning. Data, which is obtained from students' performance, reveals evidence of the general improvement of results throughout the semester with the majority of students moving from lower to higher levels. Conclusions reflect on challenging implications for sustainable transferrable practices, self-regulated learning and formative assessment for all.


The role of extra credit in the college classroom has been examined as a philosophical and pedagogical issue, but in this project, we argue that the matter of extra credit is also a sociological one. Using survey data, we examine how college instructors' status and individual demographic characteristics are related to the use of extra credit. We found that women and instructors with less teaching experience are more likely to offer extra credit. Furthermore, we also found that instructors who perceived extra credit as a means to engage students with the world beyond the classroom were more likely to offer it. We situate our findings within a broader discussion of the pedagogical merits of extra credit for creating just learning environments within sociology.


Bundle adjustment jointly optimizes camera intrinsics and extrinsics and 3D point triangulation to reconstruct a static scene. The triangulation constraint, however, is invalid for moving points captured in multiple unsynchronized videos and bundle adjustment is not designed to estimate the temporal alignment between cameras. We present a spatiotemporal bundle adjustment framework that jointly optimizes four coupled sub-problems: estimating camera intrinsics and extrinsics, triangulating static 3D points, as well as sub-frame temporal alignment between cameras and computing 3D trajectories of dynamic points. Key to our joint optimization is the careful integration of physics-based motion priors within the reconstruction pipeline, validated on a large motion capture corpus of human subjects. We devise an incremental reconstruction and alignment algorithm to strictly enforce the motion prior during the spatiotemporal bundle adjustment. This algorithm is further made more efficient by a divide and conquer scheme while still maintaining high accuracy. We apply this algorithm to reconstruct 3D motion trajectories of human bodies in dynamic events captured by multiple uncalibrated and unsynchronized video cameras in the wild. To make the reconstruction visually more interpretable, we fit a statistical 3D human body model to the asynchronous video streams. Compared to the baseline, the fitting significantly benefits from the proposed spatiotemporal bundle adjustment procedure. Because the videos are aligned with sub-frame precision, we reconstruct 3D motion at much higher temporal resolution than the input videos. Website: http://www.cs.cmu.edu/~ILIM/projects/IM/STBA.


Many companies face the risk of a data breach exposing stored personal information of customers and employees. The frequency of such incidents has been increasing over time and can result in significant costs for the affected firm. This article examines the stock market's assessment of the cost of data breaches at publicly traded companies in which personal information such as customer and/or employee data are exposed. Using event study methodology on a sample of 77 events between the beginning of 2004 and the end of 2006, we find that the overall effect of a data breach on shareholder wealth is negative and statistically significant. Based on a cross‐sectional analysis of the cumulative abnormal returns, we find a negative association between market reaction and firms that are less forthcoming about the details of the breach. We also find that firms with higher market‐to‐book ratios experience greater negative abnormal returns associated with a data breach. Further, we find that firm size and subsidiary status mitigate the negative effect of a data breach on the firm's stock price and that the negative market reaction to a data breach is more significant in the most recent time periods of the sample.


Sweyers syndrome or pure gonadal dysgenesis is characterised by primary amenorrhea , presence of female phenotype, female external genitalia and female internal genitalia with hypoplastic uterus and streak gonads. A 16 year old girl presented with secondary amenorrhoea, she attained menarche at 11 years and was followed by 4 months of regular cycles thereafter developed two years of amenorrhea. On examination she is phenotypically female with no secondary sexual characteristics, external genitalia is female. Laboratory investigations showed a high level of serum follicle stimulating hormone, Luteinising hormone which were consistent with hyper gonadotropic hypogonadism, pelvic ultrasound showed a hypo plastic uterus and hypo plastic ovaries, chromosomal analysis revealed XY Karyotype. Further she underwent alaparoscopic prophylactic gonadectomy and the histopathology confirmed hypo plastic ovaries. In conclusion we emphasise that Sweyers syndrome can present with secondary amenorrhoea with a functioning uterus with lining endometrium. The importance of timely diagnosis and gonadectomy forseeing a gonadoblastoma cannot be over emphasised.


between the methods and theories of sociology and the study of politics. Drawing from his small-group work, he offers three models of social interaction which may provide political scientists with fresh 'insights'. Indivdiuals can be regarded as being in agreement over values (consensus); in disagreement (conflict); or bemused (anomie). These models are not alternatives but operate at different levels of social reality. Hence, for Castles, the relevance of functional metatheory to the analysis of socio-political systems (though this is hardly new for political scientists are often the worst offenders); the importance of conflict meta-theory for the analysis of competitive groups and classes; and anomie, as an approach to the individual located within the political communications context.


Recently there has been substantial interest in spectral methods for learning dynamical systems. These methods are popular since they often offer a good tradeoff between computational and statistical efficiency. Unfortunately, they can be difficult to use and extend in practice: e.g., they can make it difficult to incorporate prior information such as sparsity or structure. To address this problem, we present a new view of dynamical system learning: we show how to learn dynamical systems by solving a sequence of ordinary supervised learning problems, thereby allowing users to incorporate prior knowledge via standard techniques such as L1 regularization. Many existing spectral methods are special cases of this new framework, using linear regression as the supervised learner. We demonstrate the effectiveness of our framework by showing examples where nonlinear regression or lasso let us learn better state representations than plain linear regression does; the correctness of these instances follows directly from our general analysis.


Introduction: Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibro-inflammatory disorder. Laryngotracheal manifestation is very rare; therefore, it is usually associated with complex diagnostic and therapeutic problems. Case Report: Herein, we report the case of a 35-year-old woman with idiopathic subglottic stenosis (ISGS) treated with one-step laryngotracheal reconstruction surgery. Postoperatively, the lesion was found to be a part of the IgG4-RD spectrum. Objective and subjective phoniatric tests, spirometry, and Quality of Life Questionnaire were used for the evaluation of postoperative functional results. Slide laryngotracheoplasty as a one-step surgery without stenting and tracheostomy ensured a sufficiently wide subglottic space with no adverse effect on voice quality. During a follow-up period of 22 months, endoscopy and computed tomography scan revealed no significant restenosis. The patient was able to return to premorbid activities of daily living without any further medical treatment. Conclusion: The laryngeal involvement of IgG4-RD is uncommon; however, it is a manifestation that should be included in the differential diagnosis of subglottic stenoses (SGS). Furthermore, subglottic IgG4-RD might be a potential etiological factor of ISGS and acquired airway stenosis after short-term intubation. Slide laryngotracheoplasty might be a favorable solution without stenting and tracheostomy even in special cases of SGS.


Purpose: The purpose of this study was to identify the impact of workplace bullying experience and resilience on the organizational socialization among new graduate nurses. Methods: This is a descriptive correlational study with 148 new graduate nurses working in the hospitals in B city of Korea. The instruments that were used for measuring main variables were the negative acts questionnaire-revised (NAQ-R), the Korean version of the Connor-Davidson resilience scale (CD-RISC), and the measurement tool for new nurses' organizational socialization. Results: The prevalence of workplace bullying was 22.3%, and the subjects reported moderate level of resilience. Significant negative correlations between workplace bullying and resilience, and organizational socialization were found. A significant positive correlation was found between resilience and organizational socialization. As a result of multiple regression analysis, resilience, workplace bullying, and a working in desired unit turned out to be variables that explained new graduate nurses' organizational socialization (adjusted R 2 =.514, p<.001). Conclusion: The results of this study suggested that new graduate nurses with higher resilience and less experience of workplace bullying would show higher organizational socialization. Further research is needed to identify the regulation effect of resilience in between workplace bullying and organizational socialization.


Expression of the asparagine synthetase gene is dependent on extracellular glucose concentration. This gene was knocked-down in livers of male Balb/c mice by a hydrodynamic tail vein injection of small interfering RNA (siRNA) against the gene. This knockdown resulted in a significant decrease in plasma glucose concentration. These results suggested that asparagine synthetase is a novel protein that regulates plasma glucose levels.