Pathology of the Larynx was published in 1984 and consists of 353 pages divided into 37 chapters, with 219 illustrations and 335 references. The book is organized into four major divisions: (1) the normal larynx, (2) nonneoplastic lesions, (3) squamous cell neoplasms, and (4) nonepidermoid malignancies. The illustrations are good, and the author's liberal use of whole-mount organ sections are especially helpful in appreciating the complex three-dimensional anatomy and pathology of the larynx. References for a book of this size, however, are limited, and certain key ones are missing. The index is detailed and useful. The section on the normal larynx dealing with embryologic development and normal gross and microscopic anatomy will, no doubt, be of immense value to the general pathologist. The sections on nonneoplastic lesions (especially the one relating to infections) and squamous cell neoplasms are also generally well done and informative. In the section on nonepidermoid malignancies,


The aim of the study was to analyze the effect of surgical intervention on the status of the ovarian follicular apparatus in patients with benign ovarian cystic tumors (BCOTs) based on the results of morphometric studies.Material and methods. The authors have studied surgical material of 60 patients aged 18-47 years with BCOTs: serous cystadenoma (20 cases), serous papillary cystadenoma (7 cases), mucinous cystadenoma (12 cases), mature teratoma (23 cases). Microscopic slides of ovarian tissue stained with hematoxylin and eosin were obtained and morphological structure of BCOTs, presence of the intact ovarian tissue surrounding neoplasm and the density of follicles there were studied based on their qualitative characteristics (maturity, signs of degeneration).Results. It was found out that development of fibrosis in the wall of BCOTs significantly depends on the tumor histogenesis: the greatest thickness of fibrosis was detected in serous papillary cystadenomas, the smallest in the group of mature teratomas, the average values were determined in mucinous and serous cystadenomas of the ovaries. The influence of BCOTs on the ovarian reserve does not depend on its morphological structure, localization and diameter. The intact ovarian tissue is removed along with BCOTs during adnexectomy, ovarian resection and in 48.8% of cases – during cystectomy. During cystectomy, probability of the perifocal intact ovarian tissue presence is reduced due to the growth of fibrous tissue in this area. However, the negative impact of BCOTs on the ovarian reserve occurs not only due to surgical removal of the ovarian tissue, but also as a result of inhibition of folliculogenesis at the preoperative stage.Conclusion. BCOTs of the presented morphological groups negatively affect the follicular apparatus due to both – inhibition of folliculogenesis at the preoperative stage and loss of ovarian tissue during surgery. More pronounced perifocal proliferation of fibrous tissue was noted with serous papillary cystadenomas.


Urban areas in several regions of China are exploding with growth and expanding at a rapid pace. This article examines the revenue sources local governments may use to finance the costs of rapidly expanding infrastructure and provide local public services. Starting with an examination of current urban development policy, recent reform proposals for urban land development and housing construction tax and fee reforms are studied. The primary focus is on the policy debate as to whether the existing system of multiple real estate taxes and fees, often applied once at the time of house purchase, should be converted into a unified real estate tax requiring annual payments. The potential impacts of this policy change on housing prices and patterns of housing development are analyzed.


We analyze the flow curves of a two-dimensional assembly of granular particles which are interacting via frictional contact forces. For packing fractions slightly below jamming, the fluid undergoes a large scale instability, implying a range of stress and strain rates where no stationary flow can exist. Whereas small systems were shown previously to exhibit hysteretic jumps between the low and high stress branches, large systems exhibit continuous shear thickening arising from averaging unsteady, spatially heterogeneous flows. The observed large scale patterns as well as their dynamics are found to depend on strain rate: At the lower end of the unstable region, force chains merge to form giant bands that span the system in the compressional direction and propagate in the dilational direction. At the upper end, we observe large scale clusters which extend along the dilational direction and propagate along the compressional direction. Both patterns, bands and clusters, come in with infinite correlation length similar to the sudden onset of system-spanning plugs in impact experiments.


Newcastle disease virus (NDV) features a natural preference for replication in many tumor cells compared with normal cells. The observed antitumor effect of NDV appears to be a result of both selective killing of tumor cells and induction of immune responses. Genetic manipulations to change viral tropism and arming the virus with genes encoding for cytokines improved the oncolytic capacity of NDV. Several intracellular proteins in tumor cells, including antiapoptotic proteins (Livin) and oncogenic proteins (H-Ras), are relevant for the oncolytic activity of NDV. Defects in the interferon system, found in some tumor cells, also contribute to the oncolytic selectivity of NDV. Notwithstanding, NDV displays effective oncolytic activity in many tumor types, despite having intact interferon signaling. Taken together, several cellular systems appear to dictate the selective oncolytic activity of NDV. Some barriers, such as neutralizing antibodies elicited during NDV treatment and the extracellular matrix in tumor tissue appear to interfere with spread of NDV and reduce oncolysis. To further understand the oncolytic activity of NDV, we compared two NDV strains, ie, an attenuated virus (NDV-HUJ) and a pathogenic virus (NDV-MTH-68/H). Significant differences in amino acid sequence were noted in several viral proteins, including the fusion precursor (F0) glycoprotein, an important determinant of replication and pathogenicity. However, no difference in the oncolytic activity of the two strains was noted using human tumor tissues maintained as organ cultures or in mouse tumor models. To optimize virotherapy in clinical trials, we describe here a unique organ culture methodology, using a biopsy taken from a patient's tumor before treatment for ex vivo infection with NDV to determine the oncolytic potential on an individual basis. In conclusion, oncolytic NDV is an excellent candidate for cancer therapy, but more knowledge is needed to ensure success in clinical trials.


Sluggish kinetics is the major obstruction in the reaction of water splitting. Design and development of noble metal-free, active and bifunctional electrocatalysts are crucial for the oxygen evolution reaction (OER). Transition-metal selenides have been applied as OER catalyst alternatives to noble metal-based catalysts. Herein, we report that a Fe-doped Ni3Se2 film electrodeposited on a conductive three dimensional macro-porous Ni foam (NF) substrate behaves as a robust electrocatalyst for the OER in a strongly basic medium (1 M, KOH), showing good activity compared to its un-doped counterpart. This catalyst showed excellent performance, exhibiting a current density of 10 mA cm−2 at an overpotential of 225 mV and a low Tafel slope (35.3 mV dec−1), indicating an enticing prospect in the OER.


The use of the WWW for analog microsystem design education is described. The educational products provided on the WWW are written tutorials, and simulation and measurement experiments that can be accessed by the general engineering community. The user interface to the web-controlled measurement suite is described in detail.


We derive tight exponential upper bounds on the decoding error probability of block codes which are operating over fully interleaved Rician fading channels, coherently detected and maximum-likelihood decoded. It is assumed that the fading samples are statistically independent and that perfect estimates of these samples are provided to the decoder. These upper bounds on the bit and block error probabilities are based on certain variations of the Gallager bounds. These bounds do not require integration in their final version and they are reasonably tight in a certain portion of the rate region exceeding the cutoff rate of the channel. By inserting interconnections between these bounds, we show that they are generalized versions of some reported bounds for the binary-input additive white Gaussian noise channel.


Filaments and coronal holes, two principal features observed in the solar corona, are sources of space weather variations. Filament formation is closely associated with polarity inversion lines (PILs) on the solar photosphere which separate positive and negative polarities of the surface magnetic field. The origin of coronal holes is governed by large-scale unipolar magnetic patches on the photosphere from where open magnetic field lines extend to the heliosphere. We study the properties of filaments, PILs, and coronal holes in solar cycles 20, 21, 22, and 23 utilizing the McIntosh archive. We detect a prominent cyclic behavior of filament length, PIL length, and coronal hole area with significant correspondence with the solar magnetic cycle. The spatio-temporal evolution of the geometric centers of filaments shows a butterfly-like structure and distinguishable poleward migration of long filaments during cycle maxima. We identify this rush to the poles of filaments to be co-temporal with the initiation of polar field reversal as gleaned from Mount Wilson and Wilcox Solar Observatory polar field observations, and quantitatively establish their temporal correspondence. We analyze the filament tilt angle distribution to constrain their possible origins. The majority of the filaments exhibit negative and positive tilt angles in the northern and the southern hemispheres, respectively, strongly suggesting that their formation is governed by the overall large-scale magnetic field distribution on the solar photosphere and not by the small-scale intra-active region magnetic field configurations. We also investigate the hemispheric asymmetry in filaments, PILs, and coronal holes. We find that the hemispheric asymmetry in filaments and PILs is positively correlated with sunspot area asymmetry, whereas coronal hole asymmetry is uncorrelated.


Healthcare providers have reasons to consider telemedicine technologies when determining the best practices for service provision. The use of such technologies in developing countries is still limited, and it is important to examine the readiness to telemedicine solutions at an organisational level in developing countries such as Libya in order to provide healthcare services. Therefore, a model was proposed and validated to assess telemedicine readiness in Libya from the healthcare providers' perspective. Healthcare providers' operational capability and telemedicine outcome expectations were also investigated. The results highlight that the level of telemedicine readiness could be influenced by various health-specific organisational factors including organisational capabilities and resources. The findings of this research are that various organisational factors have an impact on telemedicine readiness and thus on the implementation of such technology including healthcare providers' human resources, IT infrastructure, perceived ease of use, and prospective healthcare providers.


Using the accurate global potential energy surfaces for the 11A′, 11A′′, and 21A′ states reported in the previous sister Paper I, detailed quantum dynamics calculations are performed for these three adiabatic surfaces separately for J = 0 (J: total angular momentum quantum number). Overall reaction probabilities for O + HCl → OH + Cl and H + ClO, the branching ratio between the two reactions, effects of the initial rovibrational excitation, and product rovibrational distributions are evaluated in the total energy region Etot ≤ 0.9 eV. Significant contributions to the overall reaction dynamics are found from the two excited 11A′′ and 21A′ potential energy surfaces, clearly indicating the insufficiency of the dynamics only on the ground 11A′ surface. The detailed dynamics on the excited surfaces are reported in the third paper of this series.


Calculation of the mean long-term service speed of transport ship: Part III Influence of shipping route and ship parameters on its service speed Service speed obtainable by a ship in real weather conditions when sailing on a given shipping route, is one of the major parameters which have great impact on ship operation costs. The so far used, very approximate method of service speed prediction based on "service margin", is very little exact. In this paper a new method based on additional ship resistance dependent on mean statistical parameters of wave and wind occurring on a given shipping route, is presented. The mean long-term service speed is calculated on the basis of the calculated additional resistance and the screw propeller and propulsion engine parameters. Also, a new definition of service margin and a way of its calculation is presented apart from the results of the mean service speed calculation depending on ship's type and size and shipping route.


OBJECTIVE
This study examined whether race/ethnicity and gender predicted sentencing to anger management therapy as a probation condition.

HYPOTHESES
We predicted judges would be more likely to assign African Americans and Hispanics, and males to anger management than Caucasians and women, respectively. We hypothesized demographic variables would predict assignment to anger management beyond legal and nondefendant extralegal variables.

METHOD
Data for this study are administrative and originate from an adult probation department in southern Texas. The sample (N = 4,001; 72.3% male) was 53.4% Caucasian, 28.6% African American, 16.7% Hispanic, 0.9% other, and 0.4% unknown and included individuals who had committed violent (14.2%) and nonviolent (85.8%) offenses.

RESULTS
Data analyses consisted of binary logistic regression, with anger management placement as the dependent variable, and offense, judge, county, race/ethnicity, and gender as the independent variables. The final model emerged as statistically significant, χ²(16) = 552.76, p < .001, Nagelkerke's R² = .32. Specifically, the odds of receiving anger management were 1.71 times higher for African Americans than Caucasians, and 1.68 times higher for men than women. Exploratory analyses examining a Race/Ethnicity × Gender interaction revealed the odds of receiving anger management was significantly lower for Caucasian women than all other racial/ethnic by gender groups.

CONCLUSION
Results suggest being part of a racial/ethnic minority group or male may disproportionately increase the odds of being required to comply with extra time and fiscal requirements associated with anger management as compared to one's racial/ethnic and gender counterparts who have committed similar crimes. (PsycINFO Database Record (c) 2019 APA, all rights reserved).


We propose a fully discrete hard thresholding polynomial approximation over a general region, named hard thresholding hyperinterpolation (HTH). This approximation is a weighted $\ell_0$-regularized discrete least squares approximation under the same conditions of hyperinterpolation. Given an orthonormal basis of a polynomial space of total-degree not exceeding $L$ and in view of exactness of a quadrature formula at degree $2L$, HTH approximates the Fourier coefficients of a continuous function and obtains its coefficients by acting a hard thresholding operator on all approximated Fourier coefficients. HTH is an efficient tool to deal with noisy data because of the basis element selection ability. The main results of HTH for continuous and smooth functions are twofold: the $L_2$ norm of HTH operator is bounded independently of the polynomial degree; and the $L_2$ error bound of HTH is greater than that of hyperinterpolation but HTH performs well in denoising. We conclude with some numerical experiments to demonstrate the denoising ability of HTH over intervals, discs, spheres, spherical triangles and cubes.


Two target configurations, suitable for the Clinton P. Anderson Meson Physics Facility (LAMPF) pion production sites, are analyzed for maximum temperatures and stresses to be experienced at LAMPF's design current (800-MeV protons at 1-mA average current). A steady-state analysis is performed using the computer code TSAAS. The pulsed nature of the beam is not considered (6 percent duty). Both targets are pyrolytic graphite. One is cooled by water flowing through copper tubes bonded to the graphite; the other is cooled by water flowing through holes drilled in a copper layer bonded to the graphite. Results of both analyses indicate that the calculated maximum stresses in the heated zone and at the copper/graphite interface due to proton beam heating are substantially lower than published values of the ultimate tensile and compressive strengths of pyrolytic graphite and copper. The calculated hot-spot temperatures are below the maximum temperature allowed by evaporation loss considerations.


Findings from the first national survey on juvenile suicide in confinement are provided, and include the extent and distribution of juvenile suicides, as well as descriptive data on demographic characteristics of each victim, incident, and juvenile facility which sustained the suicide. Among the significant findings were that suicides were evenly distributed, i.e., the same number of deaths occurred within the first few days of confinement as occurred over many months of confinement; most deaths occurred during traditional waking hours; a strong association between room confinement and suicide was found, and no relationship between intoxication and suicide was found. Suicide prevention resources were found to be particularly lacking in juvenile detention centers that experienced suicides.


A matrix is similar to Jordan canonical form over the complex field and the rational canonical form over a number field, respectively. In this paper, we further study the rational canonical form of a matrix over any number field. We firstly discuss the elementary divisors of a matrix over a number field. Then, we give the quasi-rational canonical forms of a matrix by combining Jordan and the rational canonical forms. Finally, we show that a matrix is similar to its quasi-rational canonical forms over a number field.


BACKGROUND
Erythromycin is available as the free base, ethylsuccinate, estolate, stearate, gluceptate, and lactobionate derivatives. When given orally erythromycin and its derivatives except the estolate are inactivated to some extent by the gastric acid and poor absorption may result.

OBJECTIVES
To establish whether delayed release erythromycin tablets meet the bioequivalent requirement for the market.

METHODS
Sectrophotometric analysis was used to determine the dissolution percentage of the tablets in vitro. High performance liquid chromatography and IBM/XT microcomputer was used to determine the bioavailability and pharmacokinetic parameters in vivo.

RESULTS
Dissolution percentage in thirty minutes reached 28.9% and in sixty minutes erythromycin was completely released. The parameters of the delayed release tablets were Tlag 2.3 hr, Tmax.4.5 hr, and Cmax 2.123 g/ml Ka 0.38048 hr(-1) T (1/2) 1.8 hr, V*C/F 49.721 AUC 12.9155. The relative bioavailability of erythromycin delayed release tablet to erythromycin capsules was 105.31%

CONCLUSION
The content, appearance, and dissolution bioavailability of delayed release erythromycin tablets conforms to the United States pharmacopoeia standards. The tablets should be stored in a cool and dry place in airtight containers and the shelf life is temporarily assigned two years.


Recent rapid advances in high-throughput, next-generation sequencing (NGS) technologies have promoted mitochondrial genome studies in the fields of human evolution, medical genetics, and forensic casework. However, scientists unfamiliar with computer programming often find it difficult to handle the massive volumes of data that are generated by NGS. To address this limitation, we developed MitoSuite, a user-friendly graphical tool for analysis of data from high-throughput sequencing of the human mitochondrial genome. MitoSuite generates a visual report on NGS data with simple mouse operations. Moreover, it analyzes high-coverage sequencing data but runs on a stand-alone computer, without the need for file upload. Therefore, MitoSuite offers outstanding usability for handling massive NGS data, and is ideal for evolutionary, clinical, and forensic studies on the human mitochondrial genome variations. It is freely available for download from the website https://mitosuite.com.


ABSTRACT Producing accurate land-use and land-cover (LULC) mapping is a long-standing challenge using solely optical remote-sensing data, especially in tropical regions due to the presence of clouds. To supplement this, RADARSAT images can be useful in assisting LULC mapping. The fusion of optical and active remote-sensing data is important for accurate LULC mapping because the data from different parts of the spectrum provide complementary information and often lead to increased classification accuracy. Also, the timeliness of using synthetic aperture radar (SAR) fills information gaps during overcast or hazy periods. Therefore, this research designed a refined classification procedure for LULC mapping for tropical regions. Determining the best method for mapping with a specific data source and study area is a major challenge because of the wide range of classification algorithms and methodologies available. In this study, different combinations and the potential of Landsat Operational Land Imager (OLI) and RADARSAT-2 SAR data were evaluated to select the best procedure for LULC classification. Results showed that the best filter for SAR speckle reduction is the 5 × 5 enhanced Lee. Furthermore, image-sharpening algorithms were employed to fuse Landsat multispectral and panchromatic bands and subsequently these algorithms were analysed in detail. The findings also confirmed that Gram–Schmidt (GS) performed better than the other techniques employed. Fused Landsat data and SAR images were then integrated to produce the LULC map. Different classification algorithms were adopted to classify the integrated Landsat and SAR data, and the maximum likelihood classifier (MLC) was considered the best approach. Finally, a suitable classification procedure was designed and proposed for LULC as mapping in tropical regions based on the results obtained. An overall accuracy of 98.62% was achieved from the proposed methodology. The proposed methodology is a useful tool in industry for mapping purposes. Additionally, it is also useful for researchers, who could extend the method for different data sources and regions.


Yerba mate (Ilex paraguariensis A.St. Hil) and jarilla (Larrea divaricata Cav.) leaves are commonly used as tea infusions in some Latin American countries. This study was conducted to evaluate the antioxidant activity (FRAP, ABTS, and DPPH) and the inhibitory potential of yerba mate and jarilla extracts on the 3CL protease (Mpro) from coronavirus SARS-COV-2 by a molecular docking approach. The main bioactive compounds present in the plant extracts were identified by HPLC-MS. According to the results, the extracts of yerba mate and jarilla showed high antioxidant activity in DPPH (> 91 %), ABTS (> 90 %), and FRAP (> 47 mg TE/g) assays. Additionally, the phenolic compounds present in yerba mate, quercetin-3-O-rutinoside (rutin) (-9.60 kcal/mol) and 3,4-dicaffeoylquinic acid (-8.20 kcal/mol) were more effective on Mpro than the antiviral drugs remdesivir and ribavirin. The compounds rutin and 3,4-dicaffeoylquinic acid have a high affinity and interaction with one of the catalytic residues Cys145 of Mpro. The glycosylation of phenolic compounds affects biological activities: positively anti-COVID-19 and negatively antioxidant. The results suggest that extracts of yerba mate and jarilla leaves could enhance the body's antioxidant defenses and can be used to improve health.


Conventional histomorphometry of peripheral nerve entails lengthy chemical processing, ultrathin sectioning in resin, and imaging by light or electron microscopy. Multiphoton microscopy techniques exist enabling label-free and in vivo imaging of histological samples. Third-harmonic-generation microscopy has recently been demonstrated effective for imaging the myelin sheath of peripheral nerve axons in animal models. Herein, we characterize use of second and third harmonic generation microscopy for label-free imaging of murine and human peripheral nerve via a novel multicolor multiphoton microscope based on a single excitation wavelength at 1300 nm. Second harmonic generation signal from collagen centered about 650 nm delineates neural connective tissue, while third harmonic general signal centered about 433 nm delineates myelin and other lipids. In transgenic mice expressing yellow fluorescent protein linked to the thy1 promoter, three-photon-excitation with emission peak at 527 nm delineates axoplasm. We compare label-free multiphoton imaging of murine and human peripheral nerve against conventional chemical stains and discuss clinical implications of this approach in guiding intraoperative decision making in nerve transfer procedures.


Impedance Source Inverters are extremely popular these days. They offer simultaneous boosting of input voltage applied as well as inversion operation. The converter achieves this by means of a specially designed impedance network along with H - Bridge. Unlike conventional H - Bridge (HB) inverters, impedance source inverters can boost the supply voltage thereby achieving boost operation. Utilizing this feature, voltage transient due to gird side disturbance, improved control and enhanced fault tolerance capability can be achieved. There are two types of impedance source-based inverters namely Z Source Inverters (ZSI) and quasi Z Source Inverters (qZSI). In this paper, five phase qZSI fed five phase induction motor drive is discussed. V/f control is implemented to induction motor in synchronism with closed loop voltage control of quasi network output voltage. Constraints in the integrated performance are discussed and taken into consideration for development of control algorithm. Simulation results are presented for the system when subjected to different load transients thereby validating the integrated control.


Persons carrying out the protocols in this manual may encounter the following hazardous or potentially hazardous materials: (1) radioactive substances; (2) toxic chemicals and carcinogenic, mutagenic, or teratogenic reagents; and (3) pathogenic and infectious biological agents. Most governments regulate the use of these materials; it is essential that they be used in strict accordance with local and national regulations. Cautionary notes are included in many instances throughout the manual, and some specific guidelines are also provided in this appendix. However, users must proceed with the prudence and precautions associated with good laboratory practice, under the supervision of personnel responsible for implementing laboratory safety programs at their institutions and in compliance with designated guidelines of federal, state, and local officials.


Pharmacist prescribing is a growing reality in some developed counties, with varied health systems. Understanding the contribution that this activity can offer in the healthcare process, and investigating its acceptance is of utmost importance for the countries that implement and regulate this type of system. This literature review aimed to design a state-of-the-art academic investigation on the perception, opinions, and attitudes in the context of pharmacist prescribing practices in countries that have adopted this system. To achieve this, the present study conducted an investigation of the Medline, Scopus, Embase, SciELO, and Lilacs databases, resulting in the selection of 17 studies. From the analysis of the articles, three categories of discussion arose: "understanding of the practice and perceived benefits", "acceptance and adherence to the practice, and "hindrances to the practice". The results showed varied acceptance and perceptions among the different publics, depending, among other questions, on the level of knowledge and experience of the patients and health professionals, on the profile of the pharmacists, or on the prescribing modality. This study highlights some challenges involved in the practice of pharmacist prescribing, and its findings can be useful in suggesting a means through which to strengthen the practice.


Stability or instability of the elbow is contingent upon three distinct but interrelated conditions: radiocapitellar articular continuity, coronoid process integrity and medial collateral ligament competency through an intact anterior oblique ligament. The latter, the anterior oblique ligament of the medial collateral ligament both in anatomic experimentation and clinical cases appears to be the most critical factor in elbow stability. The reconstruction of the unstable elbow must focus on this medial supporting ligament for a predictable result.


Hiperglycemia and insulin resistance are common in critically ill patients, even that have not previously had diabetes. Though it has been reported that pronounced hyperglycemia may lead to complications in such patients and cause of reactive oxygen species (ROS) production, although data from controlled trial are still lacking. The debatable issue focused on whether intensive insulin therapy to normalized blood glucose improves prognosis. The debate is mainly about the time to start therapy, and target of blood glucose level. The main purpose of this research is to know the different between intensive insulin therapy and conventional insulin therapy on decreases of cytokine production (IL-6), increase of albumin level and event of systemic inflammatory respons syndrome (SIRS). The design of this study is randomized pre and post control group design involving 40 adult patients that admitted to the ICU Sanglah hospital Denpasar. They were randomly assigned to receive intensive insulin therapy in which blood glucose at the level between 80 ? 110 mg/dL or conventionl insulin therapy in which insulin therapy start if the blood glucose level exceed 215 mg/dL and blood glucose maintained at the level between 180 ? 200 mg/dL. The results of this study showed that: (1) Significant decrease of IL-6 level (10.25 vs 2.02; p=0.023); (2) Significant increase of albumin level (0.62 vs 0.22); (3) Significant decrease of SIRS (10 % vs 45%, p=0.000) on intensive insulin therapy group compare to the conventional insulin therapy group. Conclusions of this study is that the increase insulin dose as well as intensive insulin therapy can maintain blood glucose level at the level normoglycaemia between 80-110 mg/dL faster compare to the conventional insulin therapy. On the otherhand, interleukin-6 decreases cause of decreases ROS production and anti inflammatory effect of insulin. Intensive insulin therapy can increase albumin level and decrease of SIRS event on hyperglycemia in critically ill ICU patients compare to the conventional insulin therapy.


The reactions of CO/H2 mixtures in a flowing microwave (2450 MHz) reactor system have been studied experimentally. This versatile microwave plasma source catalyzes the reactions selectively to products, mainly methane and acetylene. For reaction times of 0.1 to 0.5 seconds in the pressure range of 10 to 90 torr conversions of CO to hydrocarbons ranged from 4 to 19%. Electric and magnetic field configurations in the reactor, i. e. various electromagnetic modes, appear to have only minor effects on the chemical reactions. It was observed that the conversion of CO to hydrocarbons is enhanced by high ratios of H2/CO. Based on analysis of experimental data, hydrogen radical production appears to be the controlling mechanism for producing both methane and acetylene.


Abstract Medical audit was carried out to evaluate drug therapy in a cohort of depressed patients admitted to a functional ward for the elderly. A retrospective case note study was carried out in 61 consecutive admissions with a diagnosis of depression. Seventeen of the 41 patients (41%) with a diagnosis of Manic Depressive Psychosis were not taking antidepressant medication on admission. Of the 11 patients who received Electroconvulsive Therapy seven (64%) did so under Section 3 of the Mental Health Act. Four of the 41 patients (10%) with a diagnosis of Manic Depressive Psychosis were not on prophylactic antidepressants or lithium on discharge. Seventeen of the patients (28%) were taking benzodiazepine hypnotics on admission, and 14 of these were discharged on the same type and dosage. There were no patients on more than one type of antidepressant or antipsychotic at any one time. These findings reflect deficiencies in the general practice and specialist treatment of depressive illness in an elderly cohort. The need for on-going audit in this at risk group is emphasized.


The recent advances in signal processing techniques have enabled the analysis of biosignals from brain so as to enhance the predictive capability of mental states. Biosignal analysis has been successfully used to characterise EEG signals of unipolar depression patients. Methods of characterisation of EEG signals and the use of nonlinear parameters are the major highlights of this chapter. Bipolar frontopolar-temporal EEG recordings obtained under eyes open and eyes closed conditions are used for the analysis. A discussion on the reliability of the use of energy distribution and Relative Wavelet Energy calculations for distinguishing unipolar depression patients from healthy controls is presented. The potential of the application of Wavelet Entropy to differentiate states of the brain under normal and pathologic condition is introduced. Details are given on the suitability of ascertaining certain nonlinear indices on the feature extraction, assuming the time series to be highly nonlinear. The assumption of nonlinearity of the measured EEG time series is further verified using surrogate analysis. The studies discussed in this chapter indicate lower values of nonlinear measures for patients. The higher values of signal energy associated with the delta bands of depression patients in the lower frequency range are regarded as a major characteristic indicative of a state of depression. The chapter concludes by presenting the important results in this direction that may lead to better insight on the brain activity and cognitive processes. These measures are hence posited to be potential biomarkers for the detection of depression.


Suboptimal search algorithms offer shorter solving times by sacrificing guaranteed solution optimality. While optimal searchalgorithms like A* and IDA* require admissible heuristics, suboptimalsearch algorithms need not constrain their guidance in this way. Previous work has explored using off-line training to transform admissible heuristics into more effective inadmissible ones. In this paper we demonstrate that this transformation can be performed on-line, during search. In addition to not requiring training instances and extensive pre-computation, an on-line approach allows the learned heuristic to be tailored to a specific problem instance. We evaluate our techniques in four different benchmark domains using both greedy best-first search and bounded suboptimal search. We find that heuristics learned on-line result in both faster search andbetter solutions while relying only on information readily available in any best-first search.


Abstract Performance management is an ongoing process that intends to facilitate employee performance. There are concerns that this may lead to negative employee experiences. In education, an effectively operating performance management process is crucial, considering the challenging and demanding nature of the teaching profession. Drawing on social exchange theory and the job demands-resources model, we propose that when teachers perceive performance management as a process that adheres to the principles of a so-called strong HRM system (i.e. one that communicates distinctively, consistently and reaches high levels of consensus), they will feel more appreciated, valued and energized, as signaled by higher levels of affective organizational commitment and less exhaustion. We hypothesize that, in turn, these outcomes improve teacher performance. We collected data from 458 Flemish teachers and matched these with performance ratings provided by school principals. The results show that the perceived strength of a performance management process relates negatively to teacher exhaustion while relating positively to their performance. Moreover, the relationship between perceived performance management process strength and teacher performance appeared to be indirect, operating primarily through affective organizational commitment. We discuss several theoretical and practical implications.


: A combined exposure to hypokinesia (21 days) and gamma-radiation (8 Gy) was shown to produce a synergistic effect on the level of endogenous radiosensitizers in mitochondria resulting in a low-energy shift: the compensatory reserve of the hepatocytes' energy system was utilized with a 242 per cent efficiency. The molar cholesterol/phospholipid ratio decreased. The lipid phase homeoviscosity increased significantly in microsomes.


The isolated intracranial Rosai-Dorfman disease (RDD) is extremely rare. It remains unclear for the best management of the residual lesions. In this report, the authors describe a case of primary single intracranial RDD treated with Gamma knife radiosurgery after partial resection, review all the related literatures and summarize the postoperative management data, in order to provide useful therapeutic information.A 23-year-old male presented with a more than 10-month history of dizziness, blurred vision and weakness. Preoperative MR imaging revealed a giant lesion involving the left middle cranial fossa and extending to the left cavernous sinus. He underwent fronto-temporal craniotomy and eventually achieved partial resection of the lesion. Postoperative histopathological results suggested a diagnosis of intracranial RDD. The residual lesion was treated with Gamma knife radiosurgery about 1 month after surgery. The follow-up imaging showed an obvious decrease in the size of the residual lesion.We are the second to provide the detail parameters of gamma knife therapy, which may be a reference for clinical neurosurgeons. Compared with the firstly reported case, our patient with a longer follow-up time has different therapeutic dose. Based on our own experience and an updated literature review, adjuvant stereotactic radiosurgery may be a safe and effective treatment for primary single intracranial RDD patients with incomplete excision. Other adjuvant therapies can be as an option in refractory patients.


The number of vaccines suitable for infant immunization is increasing, leading to a need to co-administer them in combination or combos. The recent demonstration of high efficacy against whooping cough using DTPa vaccines makes it desirable to administer combos such as DTPaHBIPVHib. For all vaccines included, surrogate markers for protection exist, except for pertussis. The field efficacy studies performed with DTPa vaccines did not allow the establishment of a correlate for protection. We propose to use detailed serology and cell-mediated immunity markers obtained from infant immunization studies, as well as a mouse intranasal challenge model, to monitor the immune responses induced by DTPa-combos.


This paper expands a recent proposal by the authors to rederive the Langevin equation for a test particle in a finite-size thermal bath using a perturbation approach that yields a cascade of Langevin-type equations. Such an approach produces a different viewpoint for the fluctuation-dissipation duality by expressing them on similar scales. General properties of energy sharing between the test particle and the bath are outlined, investigating the resonant and nonresonant conditions.


The changes in 2014–2015 mark the emergence of new qualitative characteristics in Russia's foreign policy. Three major themes, separately or in various combinations, are usually considered to explain this phenomenon: (i) tactical ("defensive") response to the agenda promoted by the West; (ii) strategic ("offensive") orientation towards imposing one's own agenda to other actors; and (iii) externalization of the domestic agenda allowing to rechallenge anti-regime criticism outward and to provide populist support to the government against real or alleged pressure from outside. Russia's new foreign policy has been focused upon the Crimea, Ukraine and Syria. Within each of three directions, however, problems of international order at stake are significantly broader than what geopolitics implies. These are territorial issues (border change, annexation, incorporation, cessation, etc.), compliance with international treaties and agreements, validity and importance of international guarantees, unsettled problems and disputes on the territory of the former USSR (sovereignty, "frozen conflicts", Russia's role, competitive influences of outsiders, etc.), turbulences in the Middle East (including dynamics of/within Islam), the international role of Russia in its immediate vicinities and beyond, and so on. Russia's assertiveness during the last two years has made the country "more visible" on the radars of world politics. The price to be paid for this includes sanctions, isolation and image losses. Force projection in Syria has partly compensated for the damage inflicted by the Crimean/Ukrainian case. New emphases in Russia's foreign policy could have various implications, affecting first of all such areas as international security, nuclear arms control and (non)proliferation, use of force, territorial and border disputes, sovereignty, (non)interference in domestic affairs. It is expedient, however, to prevent returning to the past and re-establishing attributes, norms and patterns that were rejected by the international community. On the contrary, the experience of the past could be helpful in overcoming current crisis (information, transparency, predictability, focusing on positive agenda and avoiding conflict escalation).


Conjugated linoleic acid (CLA) is produced by photoisomerization of soy oil linoleic acid. Yields increase with the degree of oil refining, but the effect of specific minor oil components is not known. Therefore, the objectives were to determine the effect of each soy oil minor component on CLA yields and oxidative stability after processing, to determine the effect of soy oil minor constituent interactions on CLA yields and oxidative stability, and to determine how soy oil Magnesol adsorption pretreatment affects CLA yields. Soy oils with varying levels of peroxides, tocopherols, phospholipids, free fatty acids (FFA), and lutein were each UV irradiated, and the CLA content and oxidative stability were determined. A peroxide value of above 0.8 greatly decreased CLA yields, as did phospholipids above 500 ppm. Tocopherols enhanced CLA production at low levels and reduced yields at high concentrations, while lutein and FFA had little effect. High CLA yields corresponded with a lower oil oxidative stability. The interactions between the minor components showed similar trends as seen in the single component study. These findings were supported by observations that Magnesol adsorption removed large quantities of phospholipids and peroxides from soy oil and greatly increased CLA yields but reduced the oxidative stability. Minor components, particularly peroxides and phospholipids, need to be removed from the oil to optimize CLA yields.


Clustering continues to be a significant and challenging task. Recent studies have demonstrated impressive results by applying clustering to feature representations acquired through self-supervised learning, particularly on small datasets. However, when dealing with datasets containing a large number of clusters, such as ImageNet, current methods struggle to achieve satisfactory clustering performance. In this paper, we introduce a novel method called Contrastive representation Disentanglement for Clustering (CDC) that leverages contrastive learning to directly disentangle the feature representation for clustering. In CDC, we decompose the representation into two distinct components: one component encodes categorical information under an equipartition constraint, and the other component captures instance-specific factors. To train our model, we propose a contrastive loss that effectively utilizes both components of the representation. We conduct a theoretical analysis of the proposed loss and highlight how it assigns different weights to negative samples during the process of disentangling the feature representation. Further analysis of the gradients reveals that larger weights emphasize a stronger focus on hard negative samples. As a result, the proposed loss exhibits strong expressiveness, enabling efficient disentanglement of categorical information. Through experimental evaluation on various benchmark datasets, our method demonstrates either state-of-the-art or highly competitive clustering performance. Notably, on the complete ImageNet dataset, we achieve an accuracy of 53.4%, surpassing existing methods by a substantial margin of +10.2%.


Post-graduate research students are key contributors to the research output of a university. Universities striving to grow their research and enhance their research profile face the challenge of attracting more students into Honours programs and beyond. There is also growing recognition that all students benefit from exposure to the culture and practices of research.

We describe the activities we undertook to understand the current student experience and perceptions of chemistry and physics at University of Technology Sydney. Based on the data collected, we developed strategies to attract and retain prospective research students in these disciplines. Strategies were developed and implemented that introduced all first year students into the research culture at UTS .We also describe activities targeting second and third year students that were developed to provide opportunities to engage in meaningful research activities These activities included, as examples, first year research taste experiences, introduction of Wikipedia projects and building a research culture and community.


Objective To clarify the position Canadian therapists must adopt regarding their obligation to protect others against patients' potentially violent actions. This obligation is based on jurisprudence which has been well established in the United States since the Tarasoff case, but which does not apply in Canada. Method A review of jurisprudence in Canada and recent clinical recommendations. The latter are then discussed in the Canadian context and followed by a range of suggested avenues to explore. Conclusion Professional standards could be established but they should be reviewed on a regular basis and allow flexibility for clinicians.


Portland cement (PC) is used in the production of Portland cement concrete (PCC) to construct many infrastructure components such as rigid pavements. This research aims at studying the effect of using common waste materials in Egypt as a replacement of PC in the production of PCC. Using waste materials in concrete production could be an effective measure in maintaining the environment, improving the properties of PCC, and reducing cost of production. Nowadays, pavement technologist and researchers had put their interests on nanotechnology. This paper outlines the innovation of using Nanotechnology-based waste materials as a replacement of PC to enhance the physical and mechanical properties of PCC. The experimental work, using waste materials such as ceramic waste (CW) and ground-granulated blast-furnace slag (GGBFS), was conducted in five phases. In phase 1 and phase 2, different rations were used for CW and GGBFS by weight of cement, respectively. In phase 3, the best three ratios of CW were used with the best ratio of GGBFS. In phase 4, different ratios of CW and GGBFS were used with a standard ratio of Un-Hydrated lime (UHL). In phase-5, various mix of CW, GGBFS and UHL were suggested based on previous results. Modified PCC mixtures were produced, tested and compared to the conventional concrete mixture. Results showed that the cost of PCC production is reduced by 34% in average comparing to the control mix.


In this paper we propose the resource allocation scheme for the overlaid macro-femtocell networks, which considers the type of handovers such as the inter-macrocell, macrocell-to-femtocell, femtocell-to-macrocell, or inter-femtocell in order to guarantee Quality of Service (QoS) and expand the accommodation capacity. Our proposed scheme takes into account the movement of mobile terminals, the QoS degradation, or the load control which trigger handovers in the overlaid networks, before it allocates resources dynamically. Moreover it considers QoS requirements of realtime or non-realtime mobile multimedia services such as video communication, Video on Demand (VoD) and dataa services. Simulation results show that our scheme provides better performances than the conventional one with respect to the outage probability, data transmission throughput and handover failure rate.


Objective: A new cream formulation containing hyaluronic acid 5%, complexed with a mix of a bacterial-wall-derived glycoprotein and peptide glycan complex (EDS), has been recently developed. We evaluated in a prospective, assessor-blinded, 6-week study the efficacy and tolerability of EDS in the treatment of facial seborrheic dermatitis (SD) and the effects on skin microbiota. Subjects and methods: Seventy-five subjects (mean age 46; 60 men) with moderate-severe SD of the face were enrolled. EDS cream was applied twice daily. The primary outcome was the evolution of the Investigator Global Assessment (IGA) score, evaluating erythema, scale/flaking, grade of seborrhea and itch. Superficial skin bacterial microbiome at baseline and after treatment was assessed, using the 16S rRNA gene methodology, in affected and non-affected face areas. Local tolerability was evaluated checking self-reported side effects at each visit. Results: Baseline IGA scores (mean±SD) was 10±3. The use of EDS reduced IGA score significantly by 70% at week 3 and by 88% at week 6. An increase in the abundance of Cutibacterium acnes genera associated with a significant drop of Staphylococcus genera presence was detected in affected areas. The ratio of relative abundance of genera Cutibacterium/Staphylococcus increased significantly after treatment in affected areas. The product was very well tolerated. Conclusion: Treatment with EDS applied twice daily for 6 consecutive weeks was associated with a reduction of the signs and symptoms of SD. Furthermore, after EDS cream treatment, a reequilibrating effect on facial skin microbiota was observed. The product was very well tolerated.


Background: Superficial mycoses or superficial cutaneous fungal infections are the most common mycotic infections worldwide, which involve outermost covering of skin and its appendages like hair and nail. The patients invariably try to neglect such type of infections and seek medical attention usually for cosmetic reasons and not because of discomfort. At least 10% of world's population has dermatophyte infection. Dermatophytes are by far the most significant cutaneous fungi because of their widespread involvement of population and their worldwide prevalence. The dermatophytes are a group of closely related keratinophillic fungi that invade keratinised tissues-skin, hair and nails of humans and animals to produce an infection called as dermatophytoses or ring worm. Dermatophytes colonise superficial dead or desquamating layers of skin and its appendages. Superficial mycoses have become a significant health problem affecting children, adolescents and adults in developing countries. The present study was planned to characterise the different dermatophytes, non dermatophytes, budding yeast like fungi and other fungi in various types of superficial mycoses cases and there distribution in urban and sub urban population. Specimens like skin, hairs and nail were collected and subjected to KOH wet mount preparation and culture on SDA further identification was done by LCB mount and slide culture technique. Out of 400 patients attending dermatology OPD various superficial fungal infection Specimens were collected and dermatophyte sps. were identified. T. tonsurans was the most common isolated spp from T.capitis. T. mentagrophytes was the most commonly isolated spp. from T.corporis. Candida sps. was isolated from T. cruris. NDM were isolated from T. pedis. From cases of T. unguium. Access this article online Quick Response Code: Website: www.innovativepublication.com


Doxorubicin (DOX) leads to myocardial cell damage and irreversible heart failure, which limits the clinical application of DOX. Naringin has biological functions of inhibiting inflammation, oxidative stress and apoptosis. Our aim was to investigate whether Naringin could prevent DOX-related cardiotoxicity in mice. Naringin was administered by gavage and mice were intraperitoneally injected with doxorubicin (1 mg/kg/day) for 15 days. H&E, Masson, TUNEL and others experiments were examined. NRVMs and H9C2 cells were treated with Naringin and DOX in vitro. Using IF, ELISA and Western Blot to detect the effect of Naringin and ECHS1 on cells. The results showed that Naringin could prevent DOX related cardiac injury, inhibit cardiac oxidative stress, inflammation and apoptosis in vivo and in vitro. Inhibition of ECHS1 could interfere the effect of Naringin on DOX-induced myocardial injury. Naringin may provide a new cardiac protective tool for preventing the cardiotoxicity of anthracycline drugs.


Traditionally, optical channels are manually provisioned and exist for months or years. New automated means of managing network resources, together with demands for greater flexibility from the customers, have led to the concept of dynamic optical connections. However, over time, the establishment and removal of these connections in the presence of changing traffic demands can lead to inefficient exploitation of the underlying resources. The authors propose a novel dual-layered connection management system. Distributed, fast and simplified control plane functionalities are used at the lower layer to provide efficient real-time per-connection resource management. The time-consuming optimisation functions are located in a centralised upper layer where they are able to achieve more efficient solutions that can improve the overall network utilisation. The control of the lower layer by the upper level is carried out via two means, namely: influence-based path calculation for short-lived connections and intrusive redeployment for long-lived connections. Simulation results, under a variety of conditions, show an improvement in performance of over 10% in each of the metrics considered for both long-lived and short-lived connections for two commonly cited test networks. We therefore conclude that the proposed system can offer worthwhile improvements in network performance.


Possible influences of transgressions and regressions on marine invertebrates remain questionable. Data on distribution of 25 ammonite genera in the Caucasian Sea, a typical marginal sea on the northern active margin of the Neo-Tethys Ocean, permits to evaluate an effect of the regional Callovian-Oxfordian transgression on the diversity of their assemblages. Both temporal and spatial patterns of the latter are examined. The total number of genera accelerated significantly during the Early-Middle Callovian together with a strong transgression. However, diversity declined throughout the Late Callovian-Late Oxfordian interval with its biggest losses at the Late Callovian-Early Oxfordian and the Early-Middle Oxfordian transitions, when assemblages impoverished by 40 % and 50 % respectively. This occurred despite of an ongoing transgression. Mapping assemblage diversity for 7 time slices (beginning of the Callovian, Early, Middle, Late Callovian, and Early, Middle, Late Oxfordian) permits to document that ammonites inhabited only the northern part of the Caucasian Sea, which remained shallow. The Early Callovian sea ingressed and opened new dispersal routes for ammonites, which, thus, inhabited the sea from the northwest and the northeast, i.e., from marginal seas of the Mediterranean sector of the Neo-Tethys and interior seas of the Russian Platform. Further transgression strengthened these faunal exchange and, consequently, enhanced the Middle Callovian generic diversity. Slowering of the transgression since the Late Callovian made other factors of diversity dynamics more important. Either global decrease in ammonite taxa number or shrinkage of dispersal routes due to tectonic activity in the AlpineCarpathian domain led to the gradual demise of ammonites occurred in the study region. Ammonites became unable to inhabit the deeper southern part of the Caucasian Sea during the entire Callovian-Oxfordian interval. This study suggests an absence of any simple relationship between ammonite generic diversity and transgressions/regressions.


Dear Sir, Ribalet et al. (1989) have presented interesting data on the regulation of KAav channel activity by phosphorylation, and an intriguing hypothesis to explain KAy P channel inhibition by ATP. They propose that the opening and closing of the KAvp channel can be explained by a one-site phosphorylation model, outlined in Fig. 1 A. According to the model of Ribalet et al. (1989), the opening of the KAXp channel at low [ATP]i occurs as a result of channel phosphorylation by a cAMP-dependent protein kinase. At high [ATP]~ this kinase is inhibited by an ATP-dependent protein kinase inhibitor (PKI) so that background dephosphorylation leads to inhibition of channel activity. Any subsequent opening of the channel requires the channel to be rephosphorylated and consequently requires the presence of some high-energy phosphate. The experiment shown in Fig. 1 B appears to refute this hypothesis. The experiment was performed using a modified oil-gate bath (Qin and Noma, 1988; Lederer and Nichols, 1989), which allows rapid and complete change of the solution bathing the intracellular surface of an inside-out patch of membrane. In each of the three panels, KAT P channel activity is initially high after channel isolation into an ATP-free solution. According to the hypothesis being tested, channel activity should have disappeared due to dephosphorylation with no substrate available for rephosphorylation. We have observed such behavior on isolating membrane patches into ATP-free solution in a bath that has never had ATP in it. In such a case, it is impossible for a small residual amount of ATP to be available in the solution. In the continued absence of ATP, switching to a solution containing the nonhydrolyzable ATP analogue AMP-PNP (left panel), the low energy phosphate AMP (middle panel), or ATP itself (right panel) all caused rapid channel inhibition. We presume that each nucleotide acted in a similar manner to inhibit channel activity. According to the hypothesis of Ribalet et al. (1989), channel activity would be decreased in each case because of reduced phosphorylation of the KAaV channel with continued background dephosphorylation. The critical observation with respect to the hypothesis being tested is the rapid reactivation of channel activity on switching to a nucleotide-free solution. In each case a complete restoration of channel activity is seen when the patch is returned to the nucleotide-free solution. According to the hypothesis of Ribalet et al. (1989), reopening of the KAVp channel should not occur in at least the first two of these experiments, because on exposure to a nucleotide-free solution (after having been exposed to AMP or AMP-PNP) the catalytic subunit will have AMP or AMP-PNP bound, and no high energy phosphate is available to reprime the catalytic subunit and rephosphorylate the channel. Fig. 1 C shows that the extent and time course of recovery from repeated addition or removal of AMP-PNP remain constant for at least 1 min after removal from an ATP-containing solution. Thus, the results shown in Fig. 1, B and C, and, for instance, Fig. 8 of Dunne et al. (1988) are


Recently, canonical correlation analysis (CCA) has been explored to address the fault detection (FD) problem for industrial systems. However, most of the CCA-based FD methods assume both Gaussianity of measurement signals and linear relationships among variables. These assumptions may be improper in some practical scenarios so that direct applications of these CCA-based FD strategies are arguably not optimal. With the aid of neural networks, this work proposes a new nonlinear counterpart called a single-side CCA (SsCCA) to enhance FD performance. The contributions of this work are four-fold: 1) an objective function for the nonlinear CCA is first reformulated, based on which a generalized solution is presented; 2) for the practical implementation, a particular solution of SsCCA is developed; 3) an SsCCA-based FD algorithm is designed for nonlinear systems, whose optimal FD ability is illustrated via theoretical analysis; and 4) based on the difference in FD results between two test statistics, fault diagnosis can be directly achieved. The studies on a nonlinear three-tank system are carried out to verify the effectiveness of the proposed SsCCA method.


Nitrochloromethylbenzindolines (nitroCBIs) are a new class of hypoxia-activated prodrugs for antitumor therapy. The recently reported prototypes undergo hypoxia-selective metabolism to form potent DNA minor groove alkylating agents and are selectively toxic to some but not all hypoxic tumor cell lines. Here we report a series of 31 analogues that bear an extra electron-withdrawing substituent that serves to raise the one-electron reduction potential of the nitroCBI. We identify a subset of compounds, those with a basic side chain and sulfonamide or carboxamide substituent, that have consistently high hypoxic selectivity. The best of these, with a 7-sulfonamide substituent, displays hypoxic cytotoxicity ratios of 275 and 330 in Skov3 and HT29 human tumor cell lines, respectively. This compound (28) is efficiently and selectively metabolized to the corresponding aminoCBI, is selectively cytotoxic under hypoxia in all 11 cell lines examined, and demonstrates activity against hypoxic tumor cells in a human tumor xenograft in vivo.


The miniaturization of computing devices and the need for ubiquitous communication has augmented the demand for pervasive computing. Security demands that all devices in a pervasive system must be able to authenticate each other and communicate in a secure manner. This is usually achieved through a Trusted Third Party like a Public Key Infrastructure (PKI) or a Key Distribution Centre (KDC). The establishment of such an entity in such a dynamic environment is neither feasible nor pragmatic. In this paper we present a novel mechanism for authentication and key exchange that can operate seamlessly in pervasive computing environments without the presence of a Trusted Third Party. The proposed scheme has minimal computational requirements, which makes it most suitable for devices with limited resources.


The steady-state behavior of the adaptive line enhancer (ALE) is analyzed for stationary inputs consisting of finite bandwidth signals embedded in a white Gaussian noise (WGN) background. Ana-lytic'expressions for the weights and output of the LMS adaptive filter are derived as functions of input signal bandwidth and SNR, as well as ALE length and bulk delay. The steady-state gain in broad-band SNR from input to output is derived as a function of these same four variables. For fixed ALE parameters and input SNR, it is shown that this gain increases as the input signal becomes narrower and approaches the sinusoidal limit. It is emphasized that because the correlation time of finite bandwidth signals is limited, excessively large values of the ALE bulk delay parameter result in diminished gain. Furthermore, there is an optimal filter length, whose value depends upon signal bandwidth and SNR, for which the broad-band gain is maximized. These results demonstrate the importance of including the effects of algorithm noise in analyzing the performance of real-time adaptive processors.


West Java is in the five line on the list of provinces in Indonesia with the most COVID-19 cases, as Bandung Metropolitan Area (BMA) is the second most densely populated showing the highest number after Jakarta Greater Area. Bandung Metropolitan Area consist of Bandung City, Cimahi City, Bandung Regency, and West Bandung Regency. Then, an intense movement of people created between the connected city and regency. Bandung City became the epicenter of movement BMA, since it is the province capital city, business, and education center. This fact, putting BMA at the highest risk not only for the pandemic but also socioeconomic issues. The spatial time series risk forecasting information is an essential for the decision-maker to develop a day by day policy aimed for combating the COVID-19 pandemic issue. In this study, the pandemic risk is calculated by combining vulnerability, hazard, and geodemography information. Infimap provides the People in Pixels geodemographic data, added not only the exposure of population distribution to COVID-19 but also the ratio of age. Beside those data, the daily distribution of COVID-19 cases, network data, business point, health facility point, residentials area, geodemographic (People in Pixels), and daily COVID-19 Community Mobility Reports is also been used in this study. The daily vulnerability and hazard data created since the first case on March 4th until August 21st. The hazard area is create based on the expected travel area of positive COVID- 19 patient. While the vulnerability area is create using Spatial Multi Criteria Analysis (SMCA) of following data: service area of hospital, groceries (local market), and workspace. Further, the time series data of hazard and vulnerability area was inputted to develop the forecasting model based on the machine learning pipeline of Gaussian algorithm. As a result, this study shows the possibility to predict the future risk area of COVID-19 until the next 100 days condition, based on spatial timeseries forecasting model.


In the Spallation Neutron Source (SNS) ring, multi-turn injection is employed to obtain a large transverse beam size which significantly reduces the space-charge tune shift of the accumulated beam. Careful choice of the painting scheme and bump function is required to obtain the desired beam profile together with low beam loss. In this paper we examine, both analytically and numerically, the effect of the space charge on the beam profile during multi-turn injection painting. [(a U(T))" x2][(b V(T))" y2] ' (3)


An original source- and load-pull topology based on a passive technique is presented in this paper. The proposed system consists of passive tuners and loop structures. The use of a passive loop structure in cascade with a passive tuner allows for synthesis of reflection coefficients in the order of 0.97 magnitudes at the device under test's access plane. The measurement and characterization results of a 1W GaAs MESFET device show an improvement of 0.9 dB in the gain and 6% in the power-added efficiency when the proposed impedance synthesis techniques are used.


Normal 0 21 This article comprises of an analysis of the municipal district of Jaboatao dos Guararapes, in Pernambuco, located in Brazilian northeastern, by means of a methodologial approach, from the model of the Territorial Touristic System, comprehended by the sub-systems of flow and settled, which ones, are composed by natural elements and constructed by the men. As the procces of territorialization objectify creating entailments between the object (the system) and the action (the procces), the methodological procedure developed in this article presentate in itself formated by mean of researches of primary and secondary informations, resulting in a development of system information. The relation between the sub-systems elements of settled and the dynamics of the sub-sysistems of the flow consummated allow the comprehension of the inter-report between the system elements.


We investigate the dynamics of interstellar dust particles in moderately high resolution (5123 grid points) simulations of forced compressible transonic turbulence including self-gravity of the gas. Turbulence is induced by stochastic compressive forcing which is delta-correlated in time. By considering the nearly Jeans-unstable case, where the scaling of the simulation is such that a statistical steady state without any irreversible collapses is obtained, we obtain a randomly varying potential, acting as a second stochastic forcing. We show that, in this setting, low-inertia grains follow the gas flow and cluster in much the same way as in a case of statistical steady-state turbulence without self-gravity. Large, high-inertia grains, however, are accelerated to much higher mean velocities in the presence of self-gravity. Grains of intermediate size also show an increased degree of clustering. We conclude that self-gravity effects can play an important role for aggregation/coagulation of dust even in a turbulent system which is not Jeans-unstable. In particular, the collision rate of large grains in the interstellar medium can be much higher than predicted by previous work.


This article offers a critical analysis of how narratives of a generalised withdrawal from radical politics and activism circulate within contemporary political theory. In so doing, I use the term 'narrations of apoliticality' to highlight how such narratives have a fictive and performative dimension: they have, I argue, congealed into a widely held common sense (often buttressed by affects of pessimism, gloom and despair) and become curiously resistant to sustained empirical or theoretical scrutiny. Against this backdrop, the article has four specific aims. First, it maps the general contours of narrations of apoliticality; second, it highlights why narrations of apoliticality are potentially problematic; third – drawing on Lacanian notions of fantasy and Sara Ahmed's account of affect – it explores how the affectivity of such claims renders them sticky and intransigent; and finally, it offers some thoughts on how we might decentre narrations of apoliticality in our analyses of political activism.


Most of the measurement strategies that are suggested at the international level to assess workplace exposure to nanomaterials rely on devices measuring, in real time, airborne particles concentrations (according different metrics). Since none of the instruments to measure aerosols can distinguish a particle of interest to the background aerosol, the statistical analysis of time resolved data requires special attention. So far, very few approaches have been used for statistical analysis in the literature. This ranges from simple qualitative analysis of graphs to the implementation of more complex statistical models. To date, there is still no consensus on a particular approach and the current period is always looking for an appropriate and robust method. In this context, this exploratory study investigates a statistical method to analyse time resolved data based on a Bayesian probabilistic approach. To investigate and illustrate the use of the this statistical method, particle number concentration data from a workplace study that investigated the potential for exposure via inhalation from cleanout operations by sandpapering of a reactor producing nanocomposite thin films have been used. In this workplace study, the background issue has been addressed through the near-field and far-field approaches and several size integrated and time resolved devices have been used. The analysis of the results presented here focuses only on data obtained with two handheld condensation particle counters. While one was measuring at the source of the released particles, the other one was measuring in parallel far-field. The Bayesian probabilistic approach allows a probabilistic modelling of data series, and the observed task is modelled in the form of probability distributions. The probability distributions issuing from time resolved data obtained at the source can be compared with the probability distributions issuing from the time resolved data obtained far-field, leading in a quantitative estimation of the airborne particles released at the source when the task is performed. Beyond obtained results, this exploratory study indicates that the analysis of the results requires specific experience in statistics.


Based on the meteorological and hydrological data from 1970 to 2006, the advection-aridity (AA) model with calibrated parameters was used to calculate evapotranspiration in the Hun-Taizi River Basin in Northeast China. The original parameter of the AA model was tuned according to the water balance method and then four subbasins were selected to validate. Spatiotemporal variation characteristics of evapotranspiration and related affecting factors were analyzed using the methods of linear trend analysis, moving average, kriging interpolation and sensitivity analysis. The results showed that the empirical parameter value of 0.75 of AA model was suitable for the Hun-Taizi River Basin with an error of 11.4%. In the Hun-Taizi River Basin, the average annual actual evapotranspiration was 347.4 mm, which had a slightly upward trend with a rate of 1.58 mm · (10 a(-1)), but did not change significantly. It also indicated that the annual actual evapotranspiration presented a single-peaked pattern and its peak value occurred in July; the evapotranspiration in summer was higher than in spring and autumn, and it was the smallest in winter. The annual average evapotranspiration showed a decreasing trend from the northwest to the southeast in the Hun-Taizi River Basin from 1970 to 2006 with minor differences. Net radiation was largely responsible for the change of actual evapotranspiration in the Hun-Taizi River Basin.


The pragmatist turn in Philosophy in the late XIX century and XX century was a serious attempt to refuse the privilege of the representational elements of the conscious- ness in the production of knowledge. Such privilege has its roots in Ancient Philosophy, in some consequences of the Platonic heritage, but was toughened by Modern philosophers of empiricist or aprioristic lineages within the modern concepts of Experience and Truth. With these last concepts of Experience and Truth I'm referring to the objectivising tendency that leads to identify experience with the final object resulting from the judicative fixation of relations. Due to the fixation of some basic relations the object of experience was identified and conceived with such and such characteristics as something independent of the mental or judicative activity. Such method of fixation and objectivising of relations is also present in the common-sense ideas of Reality, Experience and Truth. In the field of the theory of signs the reputation of the modern concept of representation was so vast that despite the progress in the discovery of the differential character of the linguistic units, Saussure's well-known notion of sign and the division between "signifiant" and "signifie" still kept the reference to the double across the body/mind polarity and to the "mental image" of the sign, Vorstellung, concept or "signifie," as the core of meaning. If Peirce and James agree in the refusal of the classical theory of representation, their rejection came from different horizons and their critiques don't mean the same. I'll try to show that James's and Peirce's attempts are not disjunctive, although they are not members of a simple addition. In the writings of the Tartu School and in T. Sebeok's reassessment to Peircean semeiosis one finds interesting tools to reconsider the relation to the World of the "field of consciousness" and semeiosic cycles, beyond representationalism, such as the concepts of environment and primary, secondary and tertiary modelling systems. Starting with these insights I'll propose at the end of the essay the notion of a double environment between psychic systems and systems based on communication.


Volunteers from fundamentalist churches and a Psychology of Religion class (N = 77) completed Altemeyer and Hunsberger's 1992 Fundamentalism Scale, Altemeyer's 1988 Right-wing Authoritarianism Scale, and answered questions about science, religion, and their relationship. Scores on the scales were highly positively correlated. Neither orientation correlated with seeing science as improving life, and both correlated with being troubled by newer developments in science such as organ transplants or genetic engineering. Partial correlations showed that both orientations favored religious beliefs over scientific data when there was a perceived conflict. Three subscales of right-wing authoritarianism clarified how authoritarianism correlated with other measures, thereby supporting a multidimensional conceptualization of right-wing authoritarianism.


Ab initio calculations [B3LYP/6‐311++G(2d,2p)] have been carried out on 84 conformations of 12 different sugars (hexoses), in both pyranose and furanose forms, with the idea of generating a data base for carbohydrate structural energies that may be used for developing the predictive value of molecular mechanics calculations for carbohydrates. The average value for the apparent gas phase anomeric effect for a series of 31 pairs of pyranose conformations was found to be 1.83 kcal/mol (vs. 2.67 kcal/mol with a smaller basis set used in earlier calculations). In developing MM4 to reproduce these data, it was necessary first to have good energies for simple alcohols and ethers, together with an adequate treatment of hydrogen bonding, and then to include the anomeric effect, and the ethylene glycol type system, as was previously recognized. It was also found that the so‐called delta‐2 effect, long recognized in carbohydrates, must be explicitly included, in order to obtain acceptable results. When a force field that included all of these items as developed from the small molecules based on the MM4 hydrocarbon force field was applied without any parameter adjustment to the set of hexopyranose and furanose conformations mentioned earlier, the Eβ − Eα was found to have an average value of 1.88 kcal/mol, versus 1.74 for the quantum calculations. The signed average and RMS deviations of the MM4 from the QM results were +0.15 and 0.87 kcal/mol. © 2003 Wiley Periodicals, Inc. J Comput Chem 24: 1504–1513, 2003


OBJECTIVES: To report one case of an exceptional benign prostatic pathology and its differential diagnosis with malignant tumors. METHODS: 67-year-old male who suffers an acute urinary retention requiring bladder catheterization and subsequent negative catheter removal tests. Digital rectal examination showed a small prostate, adenomatous, without nodules. PSA was 1.01 ng/ml. The patient underwent transurethral resection of the prostate because of the persistence of urinary retention. RESULTS: Pathologic study reported a hypercellular stroma, with a perivascularly distributed inflammatory infiltrate and myxoid stromal background with slightly atypical fusiform cells. Immunohistochemical studies showed positive staining of fusiform cells for vimentin and histiocytes in the lesion for CD68, and negative staining for cytokeratin. The final diagnosis was prostatic inflammatory pseudotumor. CONCLUSIONS: In spite of being an unfrequent presentation it is important to take this benign lesion under consideration to avoid unnecessary aggressive radical complementary treatments.


Hypostomus subcarinatus Castelnau, 1855 is rediscovered in the Pampulha lake, an urban lake pertaining to the rio das Velhas basin in the rio São Francisco system in the state of Minas Gerais, southeastern Brazil. Herein, H. subcarinatus is redescribed and its diagnosis from the congeners is established due to characters such as blue tan dorsal fin in live specimens, slender bicuspid teeth, dentaries angled more than 90 degrees, moderate keels along lateral series of plates, small roundish dark spots, one plate bordering supraoccipital, by having nuptial odontodes mainly on pectoral, dorsal and caudal-fin rays, and longer anal-fin unbranched ray. The rediscovery of H. subcarinatus after more than 160 years after its original description was one unexpected event, because the Pampulha lake is an artificial, shallow and polluted urban lake. The lake is located in the downtown of municipality of Belo Horizonte, the third largest urban agglomeration in Brazil with a population exceeding 5.9 million inhabitants. In the light of this finding we address the importance of urban body waters to maintenance of fish biodiversity in the neotropics.


Background Few studies have presented data on adiponectin and leptin levels comparing small and appropriate for gestational age, and very low birth weight preterm and term newborns. Aim To compare levels of adiponectin and leptin in cord blood of full term and very low birth weight preterm infants, and determine its relation with birth weight and being small for gestational age. Methods Cross sectional study of preterm with gestational age (GA) ≤32 weeks and birth weight ≤1500 grams (VLBW), and term newborns born at tertiary hospital between January 2010 and May 2011. Exclusion criteria were presence of major congenital malformation, metabolism inborn errors, chromosomal anomalies. Adiponectin and leptin cord blood levels were determined by ELISA kits (R&D Systems). Results Included 127 newborns: 55 VLBW preterm and 72 term newborns. There were no statistical differences regarding maternal gestational diabetes, urinary tract infection, age and BMI. Adiponectin levels were significantly higher in term than in preterm newborns: 2.4±0.22pg/ml versus 1.57±0.74 pg/ml (p<0.001), respectively; leptin levels were similar in both groups: 1.25 ±0.90pg/ml and 1.38 ±0.99pg/ml (p=0.481), respectively. Despite being adequate or small for gestational age, VLBW preterm newborns showed lower levels of adiponectin than term newborns (p<0.001), and there were no statistically significant differences for leptin levels. In the linear regression, prematurity was the only independent variable associated to low levels of adiponectin (p<0.001). Conclusion Prematurity is the main determinant factor for lower adiponectin levels in umbilical cord blood of newborns.


Serum specimens collected during the 2011 round of National HIV Behavioral Surveillance among men who have sex with men in San Francisco were tested for hepatitis C virus antibodies. Hepatitis C virus infection was found among men who have sex with men with a history of intravenous drug use and those who were already human immunodeficiency virus infected.


The article deals with findings of the studies on the efficiency of treatment for acute poisoning with chlorpyrifos in a young child. We studied the efficiency of multicomponent intensive therapy with antidotal drugs. Conclusions about the efficiency of antidote therapy scheme use were made.


The paper presents the results of theoretical and experimental studies of thermal plasma heating and melting of agglomerated powder based on quartz sand screenings of the Tugan Deposit, Tomsk region, Russia. It is shown that phase transitions significantly affect the process of thermal plasma heating and melting of agglomerated powder, which can lead to unjustified heating of particles. The results of thermochemical processes due to heating are presented herein. It is found that the total concentration of phases subjected to evaporation at the initial stage, is rather small (0.13 wt.%). The model is proposed for the hollow particle formation from silicon dioxide agglomerates.


OBJECTIVE To determine the prevalence of myositis specificautoantibodies (MSAs) and several myositisassociated autoantibodies (MAAs) in a large group of patients with myositis. METHODS A total of 417 patients with myositis from 11 European countries (198 patients with polymyositis (PM), 181 with dermatomyositis (DM), and 38 with inclusion body myositis (IBM)) were serologically analysed by immunoblot, enzyme linked immunosorbent assay (ELISA) and/or immunoprecipitation. RESULTS Autoantibodies were found in 232 sera (56%), including 157 samples (38%) which contained MSAs. The most commonly detected MSA was anti-Jo-1 (18%). Other anti-synthetase, anti-Mi-2, and anti-SRP autoantibodies were found in 3%, 14%, and 5% of the sera, respectively. A relatively high number of anti-Mi-2 positive PM sera were found (9% of PM sera). The most commonly detected MAA was anti-Ro52 (25%). Anti-PM/Scl-100, anti-PM/Scl-75, anti-Mas, anti-Ro60, anti-La, and anti-U1 snRNP autoantibodies were present in 6%, 3%, 2%, 4%, 5%, and 6% of the sera, respectively. Remarkable associations were noticed between anti-Ro52 and anti-Jo-1 autoantibodies and, in a few sera, also between anti-Jo-1 and anti-SRP or anti-Mi-2 autoantibodies. CONCLUSIONS The incidence of most of the tested autoantibody activities in this large group of European patients is in agreement with similar studies of Japanese and American patients. The relatively high number of PM sera with anti-Mi-2 reactivity may be explained by the use of multiple recombinant fragments spanning the complete antigen. Furthermore, our data show that some sera may contain more than one type of MSA and confirm the strong association of anti-Ro52 with anti-Jo-1 reactivity.


A therapeutic compound with antioxidant and anti‐inflammatory effects might be a practical approach in endothelial dysfunction caused by oxidation and inflammation associated with atherosclerosis. Therefore, we aim to examine the efficacy of Nigella sativa (NS) oil supplementation on endothelial function and atherogenic indices in coronary artery disease (CAD) patients. Sixty individuals aged between 35 to 65 years old were recruited and divided into two groups, receiving either 2 g/daily of NS oil or sunflower oil as the placebo for 8 weeks. Serum levels of adhesion molecules, oxidative markers, and atherogenic parameters were evaluated at the starting point and the end of supplementation. Serum levels of vascular cell adhesion protein 1 (sVCAM‐1) [−264.44 95% C, (156.83, 372.04)], intercellular adhesion molecule 1 (sICAM‐1) [−132.38 95% C, (40.64, 224.1)], and malondialdehyde (MDA) [−0.21 95% C, (0.03, 0.40)] declined significantly following NS supplementation, while total antioxidant capacity increased [0.03 95% C, (0.03, 0.16)]. NS oil supplementation demonstrated a potential beneficial effect on endothelial function by reducing ICAM‐1, VCAM‐1 levels and affecting oxidative markers. However, further studies are necessary to elucidate NS oil as a therapeutic agent and complementary therapy in patients with stable CAD.


We develop resource and service management techniques to support secondary users (SUs) with QoS requirements in large-scale distributed dynamic spectrum access (DSA) systems. The proposed techniques empower SUs' to seek and exploit spectrum opportunities dynamically and effectively, thereby maximizing the SUs' long-term received service satisfaction levels. Our techniques are efficient in terms of optimality, scalability, distributivity, and fairness. First, they enable SUs to achieve high service satisfaction levels by quickly locating and accessing available spectrum opportunities. Second, they are scalable by performing well in systems with small as well as large numbers of SUs. Third, they can be implemented in a decentralized manner by relying on local information only. Finally, they ensure fairness among SUs by allowing them to receive equal amounts of service.


In this paper the additional value of using Belief Networks in clinical decision analysis is argued. Differences between these two approaches are demonstrated with the help of a clinical example.


The goals of acute treatment in migraine should be sustained pain-free response, which will reduce disability and optimally restore function with minimal adverse events and cost. A validated four-item tool, Migraine-ACT, can measure adequacy of acute treatment. The strategy for picking the right acute treatment initially should be one of stratified care, matching patient need to migraine characteristics. Disability is a surrogate marker for disease severity, allowing for the decision as to when to use migraine-specific treatment versus nonspecific treatment in the absence of vascular disease. The evidence for efficacy of nonspecific treatments in migraine is mixed, due to variabilities in study designs, but they can be effective for moderate level migraine with low disability. Most studies for acute treatment with oral opioids have been poorly designed or negative. No randomized controlled trials have shown benefit for butalbital mixtures in the acute treatment of migraine. Migraine-specific treatments include triptans and ergots. Triptans are divided into groups by speed of onset and formulation. When possible, patients should be instructed to take these medications early in the migraine attack to make a sustained pain-free response more likely. Ergot use is limited by poor oral absorption and adverse events.


The term "cell-free DNA" (cfDNA) was recently coined for DNA fragments from plasma/serum, while DNA present in in vitro cell culture media is known as extracellular DNA (ecDNA). Under oxidative stress conditions, the levels of oxidative modification of cellular DNA and the rate of cell death increase. Dying cells release their damaged DNA, thus, contributing oxidized DNA fragments to the pool of cfDNA/ecDNA. Oxidized cell-free DNA could serve as a stress signal that promotes irradiation-induced bystander effect. Evidence points to TLR9 as a possible candidate for oxidized DNA sensor. An exposure to oxidized ecDNA stimulates a synthesis of reactive oxygen species (ROS) that evokes an adaptive response that includes transposition of the homologous loci within the nucleus, polymerization and the formation of the stress fibers of the actin, as well as activation of the ribosomal gene expression, and nuclear translocation of NF-E2 related factor-2 (NRF2) that, in turn, mediates induction of phase II detoxifying and antioxidant enzymes. In conclusion, the oxidized DNA is a stress signal released in response to oxidative stress in the cultured cells and, possibly, in the human body; in particular, it might contribute to systemic abscopal effects of localized irradiation treatments.


Needle insertion simulations play an important role in medical training and surgical planning. Most simulations require boundary conforming meshes, while the diffuse domain approach, currently limited to stiff needles, eliminates the need for meshing geometries. In this article the diffuse domain approach for needle insertion simulations is first extended to the use of flexible needles with bevel needle tips, which are represented by an Euler-Bernoulli beam. The model parameters are tuned and the model is evaluated on a real-world phantom experiment. Second, a new method for the relaxation of the needle-tissue system after the user releases the needle is introduced. The equilibrium state of the system is determined by minimizing the potential energy. The convergence rate of the coupled Laplace equations for solving the Euler-Bernoulli beam is 1.92 ± $$ \pm $$ 0.14 for decreasing cell size. The diffuse penalty method for the application of Dirichlet boundary conditions results in a convergence rate of 0.73 ± $$ \pm $$ 0.21 for decreasing phase field width. The simulated needle deviates on average by 0.29 mm compared to the phantom experiment. The error of the tissue deformation is below 1 mm for 97.5% of the attached markers. Two additional experiments demonstrate the feasibility of the relaxation process. The simulation method presented here is a valuable tool for patient-specific medical simulations using flexible needles without the need for boundary conforming meshing. To the best of the authors' knowledge this is the first work to introduce a relaxation model, which is a major step for simulating accurate needle-tissue positioning during realistic medical interventions.


Chitosan (CHI) blended polycaprolactone (PCL) nano/micro fibers were prepared with different CHI content via electrospinning procedure. Two different solvents, acetone and formic acid (FA) were used to dissolve and blend the polymers before electrospinning process. Effect of the solvent on the electrospinability of the blend, final nano/micro fiber morphologies, chemical and thermal properties and antibacterial activities were investigated with SEM, FTIR, DSC, and ASTM 2149 01 Standard Dynamic Contact Conditions. The results revealed that chitosan particles were encapsulated in the as-spun PCL fibers with using acetone as the solvent resulted in reduced antibacterial activities Contrarily, when FA is used as the solvent, CHI and PCL were dissolved and blended very well, and enhanced antibacterial activities were obtained from as-spun PCL/CHI nano/micro fibers.


We discuss the new era of precision QCD as it relates to the physics requirements of the LHC for both the signal and background type processes. Some attention is paid to the issue of the theoretical error associated with any given theoretical prediction. In the cases considered, we present where the theory precision is at this writing and where it needs to go in order that it not impede the discovery potential of the LHC physics program. To complete the discussion, we also discuss possible paradigms the latter program may help us understand and some new developments that may play a role in achieving that respective understanding.


Active learning, a label-efficient paradigm, empowers models to interactively query an oracle for labeling new data. In the realm of LiDAR semantic segmentation, the challenges stem from the sheer volume of point clouds, rendering annotation labor-intensive and cost-prohibitive. This paper presents Annotator, a general and efficient active learning baseline, in which a voxel-centric online selection strategy is tailored to efficiently probe and annotate the salient and exemplar voxel girds within each LiDAR scan, even under distribution shift. Concretely, we first execute an in-depth analysis of several common selection strategies such as Random, Entropy, Margin, and then develop voxel confusion degree (VCD) to exploit the local topology relations and structures of point clouds. Annotator excels in diverse settings, with a particular focus on active learning (AL), active source-free domain adaptation (ASFDA), and active domain adaptation (ADA). It consistently delivers exceptional performance across LiDAR semantic segmentation benchmarks, spanning both simulation-to-real and real-to-real scenarios. Surprisingly, Annotator exhibits remarkable efficiency, requiring significantly fewer annotations, e.g., just labeling five voxels per scan in the SynLiDAR-to-SemanticKITTI task. This results in impressive performance, achieving 87.8% fully-supervised performance under AL, 88.5% under ASFDA, and 94.4% under ADA. We envision that Annotator will offer a simple, general, and efficient solution for label-efficient 3D applications. Project page: https://binhuixie.github.io/annotator-web


The products obtained during the early stages of the oxidative polymerization of aniline in the "falling pH" reaction were investigated using multinuclear solid-state magic-angle spinning (MAS) NMR combined with first-principles NMR chemical shielding calculations using the GIPAW (gauge-including projector augmented wave) method. A sample was synthesized starting from a 50:50 mixture of U–13C aniline and 15N-labeled aniline; two-dimensional 13C refocused INADEQUATE, 15N–13C double CP, 15N PDSD, and 1H–13C/15N refocused INEPT MAS NMR spectra revealed the presence of quinoneimine structural units. Structural models that are consistent with the connectivities revealed by the 13C refocused INADEQUATE and 15N–13C Double CP spectra are proposed. GIPAW chemical shift calculations are performed for model structures based on the proposed oligomeric structures; noting that the model structures do not take into account intermolecular hydrogen bonding and CH−π interactions, agreement and discrepancy to experiment are...


Businesses and organizations, including public authorities, have a growing need for organizing and handling large amounts of data. In order to manage complex knowledge, knowledge must be modeled and structured. One very powerful method used for structuring knowledge is the use of ontologies. Businesses and organizations need efficient tools for building domain-specific ontologies and systems for managing knowledge. Most medium-sized and large Danish businesses and organizations operate in a bilingual or multilingual environment, where knowledge is transferred and stored in Danish and/or English, and possibly other languages, so information must be freely retrievable and communicable in several languages. In this paper I will give examples of why knowledge modeling is important for businesses, and why knowledge modeling is a central part of the DanTermBank project, the aim of which is to lay the foundation for a national terminology and knowledge bank. Furthermore, I will briefly introduce our plans for teaching within the field of knowledge modeling at Copenhagen Business School, CBS.