The aim of this study was to investigate factors that increase the chances of British psychiatric patients having multiple hospital re-admissions. Data were collected on all 128 patients who had been admitted to a psychiatric ward in the course of a year. Patients who had been admitted at least three times to the hospital were classified as 'Revolving-door' patients and compared to patients with less than three admissions. From the 128 studied patients, 51% had three or more re-admissions. The results indicate that 'Revolving-door' patients were more likely to be living alone, in hostels or private accommodation and to have an earlier age of illness-onset and have used psychiatric services for a longer period. They were also likely to have been prescribed more medication and to have been diagnosed with psychoactive substance abuse. In addition, the results of a logistic regression analysis indicate that 'relapse of psychosis' is the best predictor for re-admission. Implications for community-care services...


An effect of anisoplanarity is caused by difference of aberrations on paths of the direct and reference beams. These differences are due to variances of path geometric characteristics (different angles or divergence) or due to the presence of temporal lag. In many cases the causes of these factors are similar, moreover, methods of their mathematical representations are similar too. Next factor limiting the possibility to use adaptive correction for turbulent aberrations is fast motion of an object. This imposes strict conditions on the rate of adaptive control and on the power of a Rayleigh beacon.


For educators located in the Global North or South what it means to work with families in inclusive settings is often a reflection of fundamental conceptions of the very nature of schooling and learning. These conceptions, whether implicit or explicit theories, inform teacher practice, interaction, communication, and involvement when it comes to students' parents, families, and communities. Understanding how theories of learning relate to family engagement and inclusive practices allows for (a) an accounting of established knowledge and practices and (b) more innovative future directions for engaging parents, families, and communities in schooling.
 Three specific theories of learning (behaviorist, sociocultural, and critical) demonstrate stark differences in how the roles of parents and family are understood in their children's education. Each of these theoretical lenses produces different answers to the question of what it means to work with families. They entail different conceptualizations of parent/family engagement and inclusion, the challenges to this engagement and inclusion, and the tools used to address these challenges. Families can be positioned as passive recipients of knowledge, contributors to knowledge, or knowledge-makers. Regarding their child's schooling, parents can be seen as supporters, contributors, or collaborators. They can be situated on the periphery of schooling or in the center.
 Contrasting and complementary elements of behavioral, sociocultural, and critical theories of learning provide insight into traditional, relational, and transformative approaches to working with families. These theoretical approaches entail practical implications as well, reflected in both standard educational practices and in extant findings in the field of educational research. This theoretical/practical approach allows for insight into why, in application, there is dissonance in perspectives among educators about how to work with families and what this work may entail and look like, and provides suggestions for how families and communities might come to play a more central role in the education of their children.


As a relatively new, imported word, the term desain (design) in Indonesian is still mostly understood within its relations to three common academic fields—graphic, interior, and product design—and thus tends to be viewed as belonging to the 'merely' visual. While local cultural events and festivals have proliferated in Indonesia, the scope for a conference or a festival that explicitly address design therefore tends to be rather limited. This is not to say that design exhibitions and festivals do not exist. In fact, they have flourished in the country, particularly among university students, reflecting the growth of university design programs and schools to meet contemporary demand. Yet visual-based, market-led development has not been accompanied by institutional development in research and outreach (in the form of dialogues or critical publications), particularly ones that connect that development across different fields. Attaching the word desain to an event in Indonesia invariably means it is associated with either design student exhibitions, or an industrial expo showcasing printers or interior furnitures. This curated piece emerges as our reflection on designing—cobbling up, and calibrating—a design conference-festival from Surabaya, East Java, Indonesia in light of the national context in which desain is received and made meaningful.


Sorbitol is an important source of abiotic stress that is used to increase osmolality in cell cultures. It increases the antioxidant enzymes of defense catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD) in the stress state of cells. Sorbitol plays an important role in stimulating these enzymes in cells and increasing phenylalanine ammonium lyase (PAL) activity. The aim of this study was to apply increasing doses of sorbitol elicitor to cell suspension cultures to determine the changes in cell number, viability, dry weight, and camphor content. In vitro plantlets were obtained from plant seeds and stem segments of these plants were used as explant source. Cell cultures were established after callus formation. Then, 0 (control), 5, 25, and 50 g L -1 sorbitol was dissolved in distilled water and cultured. Samples were taken three times in total, starting from day 1 to day 3. The content of camphor was detected by gas chromatography-mass spectrometry (GC-MS). Cell number, viability,dry weight, and camphor content increased significantly with increasing doses of sorbitol compared to sampling times. Compared to the initial culture, the amount of camphor increased by 40% at the 5 g L -1 dose, 82% at the 25 g L -1 dose, and 154% at the 50 g L -1 dose. In A. gypsicola cell cultures, increasing doses of sorbitol have clearly demonstrated the secondary metabolite accumulation and its positive effect on cell growth.


A definite rise in plasma 11-hydroxycorticoid levels has been shown in eight patients with duodenal ulcer following the oral administration of carbenoxolone sodium. A similar rise was seen in one patient with sarcoidosis whose pituitary A.C.T.H. secretion had been acutely suppressed with dexamethasone. No such rise, however, was seen in three patients suffering from adrenal insufficiency. It is suggested that carbenoxolone acts directly on the adrenal cortex, causing an increased production of corticosteroids.


Trade among Arab countries has been very weak despite previous efforts to engage into different forms of regional economic integration. Using the flexible framework provided by the Gravity Model, the paper gives an order of magnitude of the main factors often presented in explaining the weakness of inter-Arab Trade. The results of the model together with several indicators about export profiles, trade correspondence, and revealed comparative advantage, are used to examine the prospects of increased inter-Arab trade following the liberalization of trade envisaged under the newly established Arab Free Trade Area (AFTA). We are able to establish a tentative list of commodities that represent opportunities for expanded trade as well as a list of partner countries'that have higher chances of benefiting from trade liberalization under AFTA. We argue that although the possibilities for expanded inter-Arab trade are real, the realization of these possibilities requires, among other things, the improvement of transport links among Arab countries and the de-linking of political from economic relationships between the latter countries.


The thesis you are about to read is the resolution of a Data Mining classification problem. The problem was proposed in the Data Mining Competition of 2013 which is organized yearly by Prudsys AG (a top company in the data mining field). The task was centered on e-commerce where the objective was to predict if a customer is going to place an order in a certain web-shop. Following the structure of the CRISP-DM Process, in the first part of the thesis (Business Understanding) we will talk about the background of the problem. It goes without saying that e-commerce has become a cutting edge industry and has been growing rapidly throughout the last decade. This growth has been led by the development of the internet and technologies such as tablets or cell phones. Nowadays, nearly every shop has a web-shop where you can buy exactly the same. It is up to you moving from your sofa… The middle part of the thesis corresponds to the Data Understanding and Data Preparation phases. In this part I will explain how to deal with the data set given, how to handle the great amount of existing missing values and how to choose the correct attributes for the purchase prediction. Important emphasis has to be made to the preparation of the dataset as it is a keystone of a successful data mining work. In the next section of the thesis I will talk about the Modeling and Evaluation phases. To learn more about different modeling techniques I will use four different algorithms which I will afterwards evaluate with two types of criteria: numerical (f-measure) and visual (lift chart). The lift chart will allow me to compare my models to a random selection method. To finish with my thesis, I will draw the conclusions of my thesis, evaluate the achievement of the objectives previously set and mention the possible tasks that could be carried out in the future to optimize the thesis.


Newly developed software has illustrated that the safe mudweight window to avoid borehole collapse and fracturing can be obtained from the direct use of drilling rind/or the use of sonic data. Instantaneous or post anrdysis using inverted drilling operational data like WOB, RPM, flowrate, and mud properties can be done by applying an inverted ROP model to prdlct rock compressive strength. This rock compressive strength is then used in conjunction with survey, in-situ stresses and rock failure criteria to predict the safe mud weight window. The sonic logs are also used to obtain the rock compressional properties through published correlations. The rock compressive strength is then used the same way as the drilling data approach. This paper gives a solid field example from a North Sea well where both methods are applied and compared. The field case provides proof that the new software is a very good tool for predicting a safe mud weight window to avoid borehole collapse and fracturing while drilling. Introduction During drilling operations it is crucial to maintain the hydrostatic mud weight pressure between the fracture and collapse pressure at any depth to ensure trouble free drilling. The casing program is also dictated mainly from the fracture and collapse gmdent. Therefore, the knowledge and use of the correct lkacture and collapse gradients can save the operating companies large sums of money. When estimating the safe operational mud weight window two important parameters are 1. the strength crfthe rock, and 2. the stress conditions the rock is subjected to. The question is; how can these parameters be monitored while Milling a well. Today there is no way of measuring compressive rock strength or stresses while drilling. The best methcd of determining compressive rock strength is by triaxial testing of core samples, but the problem is that these data will then only be available after the well is completed, These triaxial data are then used in conjunction with logs through correlations when planning the next well. This paper describes a decision support system for well planning, and follow-up of well integrity (safe operating mud weight window) during drilling operations. The system, is a Windows based modular system, using Internet as the communication network for data exchange and technological support] . One module in the system is the inverted ROP module which back calculates the compressive strength of the formation while drilling. This in-situ compressive strength will be used dynamically to calibrate the in-situ stresses2 which in conjunction with knowledge of the overburden and pore pressure, and the wellbore survey dictates the collapse and fracture pressure for the wellbore instantaneously. If the well has already been drilled and the above information is available, the true verticat depth collapse and fracture gradient can be predicted as part of the post analysis or for pre-planning the next well in the area. Another approach to obtain the collapse and fracture gradient is from log dam where the rock compressive strength of the rock is estimated from the sonic travel times3" 4. After the compressive strengths as a finction of depth are estimated the same approach as for the use of drilling data to obtain in-situ stresses is applied2. Using such a decision support software system, data may also be more readily available for display instantaneously or for use in future planning, thus providing a more complete set of data for design prognosis. Drilling data can easily be


Management of terrestrial nitrogen (N) has been identified as a key challenge in the implementation of sustainable agricultural practices. Transformations of inorganic N are mainly performed by microbial functional guilds that regulate the retention or loss of N. Soil management may affect the diversity, composition, and functioning of N-cycling microbial communities. The aim was to define the influence of soil properties, crops and intercropping on root- and soil-associated N-cycling communities with a special focus on the genetic and enzymatic potential for denitrification and nitrous oxide (N₂O) reduction.

A greenhouse experiment comparing intercropped cocksfoot and lucerne with sole cropping practices showed that plant species and intercropping significantly affected the abundances of root associated communities that drive the retention or loss of N, suggesting altered plant-microbial and/or microbial-microbial interactions. Addition of biogas digestate as fertilizer did not alter the intercropping effects. A higher N₂O production rate was found in root-associated microbial communities in cocksfoot during intercropping, which coincided with decreased genetic potential for N₂O reduction by organisms within nosZ clade II compared to sole cropped cocksfoot. Sequencing revealed that these N₂O reducers were related to Ignavibacteria, which have a truncated denitrification pathway that lacks the genetic capacity to produce N₂O.

Soil type also had a strong influence on root-associated N-cycling communities. In a full-factorial experiment with two soil types and two different crops (barley and sunflower), soil type overrode crop effects regarding both genetic and enzymatic potential for denitrification. Thus, soil physical and chemical properties rather than plant species determine the denitrification and N₂O production rates of the root-associated communities.

The genetic potential for the various N-cycling communities differed between bulk soil and roots, indicating that N-cycling functional organisms were favored in different compartments in the soil-root environment. The N₂O reducing organisms carrying nosZI were shown to have an affinity to plant roots, whereas those with nosZII prefer the bulk soil thus indicating a possible niche differentiation between the two clades.


Delays in treatment of in-hospital cardiac arrests (IHCAs) are associated with worsened survival. We sought to assess the impact of a bundled intervention on IHCA survival in patients on centralised telemetry. A retrospective quality improvement study was performed of a bundled intervention which incorporated (1) a telemetry hotline for telemetry technicians to reach nursing staff; (2) empowerment of telemetry technicians to directly activate the IHCA response team and (3) a standardised escalation system for automated critical alerts within the nursing mobile phone system. In the 4-year study period, there were 75 IHCAs, including 20 preintervention and 55 postintervention. Cox proportional hazard regression predicts postintervention individuals have a 74% reduced the risk of death (HR 0.26, 95% CI 0.08 to 0.84) during a code and a 55% reduced risk of death (HR 0.45, 95% CI 0.23 to 0.89) prior to hospital discharge. Overall code survival improved from 60.0% to 83.6% (p=0.031) with an improvement in ventricular tachycardia/ventricular fibrillation (VT/VF) code survival from 50.0% to 100.0% (p=0.035). There was no difference in non-telemetry code survival preintervention and postintervention (71.4% vs 71.3%, p=0.999). The bundled intervention, including improved communication between telemetry technicians and nurses as well as empowerment of telemetry technicians to directly activate the IHCA response team, may improve IHCA survival, specifically for VT/VF arrests.


ABSTRACT Agent-based models tend to integrate more and more data that can deeply impact their outcomes. Among these data, the ones that deal with agent attributes and localization are particularly important, but are very difficult to collect. In order to tackle this issue, we propose a complete generic toolkit called Gen* dedicated to generating spatially explicit synthetic populations from global (census and GIS) data. This article focuses on the localization methods provided by Gen* that are based on regression, geometrical constraints and spatial distributions. The toolkit is applied for a case study concerning the generation of the population of Rouen (France) and shows the capabilities of Gen* regarding population spatialization.


The aim of this study was to characterize the healing process of extraction sockets with a periapical lesion following immediate graft with collagenated bovine bone mineral (CBBM) soaked with epigallocatechin-3-gallate (EGCG). Following induction of periapical lesions in premolars in five dogs, treatment of extraction sockets was divided into three groups: control (no treatment) and two test groups, CBBM with or without EGCG. 3D reconstruction and superimposition of the digital images were used to measure the dimensional changes in alveolar ridge. Histologic specimen was evaluated in all groups. The horizontal ridge widths at 4-mm level were wider in both test groups (3.3 ± 1.7 mm in CBBM; 3.0 ± 1.7 mm in CBBM+EGCG) than in the control group (1.7 ± 2.4 mm). Fibrosis and limited new bone formation were observed in the apical regions of test groups; however, the extent of fibrosis was less in the CBBM+EGCG group. Within the limitations of this study, it was conjectured that adjunctive use of EGCG with CBBM can be a candidate biomaterial in grafting of extraction socket with periapical lesion. Bone regeneration at the coronal region of the CBBM grafted socket might not be influenced by the presence of a periapical lesion.


Coal permeability model is needed to define the transient characteristics of coal permeability evolution due to adsorbing gas injection. A broad variety of models have evolved to represent the effects of sorption, swelling/shrinkage and effective stresses on the evolution of permeability. This work evaluated the performance of these models against analytical solutions for both unconstrained swelling and constrained swelling conditions. Constrained model predictions are apparently consistent with typical laboratory measurements. Nevertheless, this consistency is due to the mismatch between model boundary condition (constrained) and experiment boundary condition (unconstrained), demonstrating that current permeability models can hardly explain net reductions in coal permeability where swelling is unconstrained. To explore the possible reason, a full coupling approach was applied to explicitly model the interactions of coal matrix-fracture and translate these interactions into the permeability change. In this approach, the important non-linear responses of coal matrix to the effective stress are quantified through the incorporation of heterogeneous distributions of coal properties into complex mechanical coupling with gas transport. When swelling coefficient and modulus vary spatially relative to the fracture void, a net reduction in coal permeability is achieved from the initial no-swelling state to the final equilibrium state. These modeling results are consistent with the observed responses under the unconstrained swelling conditions, which demonstrates the contribution of this work. Copyright 2013 ARMA, American Rock Mechanics Association.


Several gaps and errors in "Precoding and Artificial Noise Design for Cognitive MIMOME Wiretap Channels" by Fang et al. are identified and corrected. While accommodating these corrections, a rigours proof is given that the successive convex approximation algorithm of Fang et al. for secrecy rate maximization (SRM) does generate an increasing and bounded sequence of true secrecy rates and hence converges. It is further shown that its convergence point is a KKT point of the original SRM problem and, if the original problem is convex, this convergence point is globally-optimal, which is not necessarily the case in general. An interlacing property of the sequences of the true and approximate secrecy rates is established.


We present a neural network-based system for long-term, multi-action human motion synthesis. The system, dubbed as NEURAL MARIONETTE, can produce high-quality and meaningful motions with smooth transitions from simple user input, including a sequence of action tags with expected action duration, and optionally a hand-drawn moving trajectory if the user specifies. The core of our system is a novel Transformer-based motion generation model, namely MARIONET, which can generate diverse motions given action tags. Different from existing motion generation models, MARIONET utilizes contextual information from the past motion clip and future action tag, dedicated to generating actions that can smoothly blend historical and future actions. Specifically, MARIONET first encodes target action tag and contextual information into an action-level latent code. The code is unfolded into frame-level control signals via a time unrolling module, which could be then combined with other frame-level control signals like the target trajectory. Motion frames are then generated in an auto-regressive way. By sequentially applying MARIONET, the system NEURAL MARIONETTE can robustly generate long-term, multi-action motions with the help of two simple schemes, namely"Shadow Start"and"Action Revision". Along with the novel system, we also present a new dataset dedicated to the multi-action motion synthesis task, which contains both action tags and their contextual information. Extensive experiments are conducted to study the action accuracy, naturalism, and transition smoothness of the motions generated by our system.


Cobalamin C deficiency (CblC) is the most frequent inborn error of cobalamin (Cbl) metabolism, which has a wide clinical spectrum. Cbl C defect causes the accumulation of methylmalonic acid and homocysteine and decreased methionine synthesis. Here we presented two distinct clinical forms of patients with CblC. First patient with early onset form was presented with failure to thrive, mild hypotonia, megaloblastic anemia and leukopenia at 2.5 months old. Second patient was presented with mental status changes, loss of speech, inability to walk and megaloblastic anemia at 12 years old. Laboratory analysis showed hyperhomocysteinemia, low plasma methionine levels and high urinary methylmalonic acid in both patients. Molecular analysis supported the diagnosis of CblC and treatment resulted in improvement of biochemical abnormalities, and neurologic findings in both patients.


Human serum albumin (HSA) is the most abundant protein in blood plasm. This protein consisted of 585 amino acids with a molecular weight of 66 kDa and 17 disulfide bonds. HSA obtained from conventional technique allow viral or prion contamination. For that reason, recombinant DNA technology becomes a promising alternative. Because of its well-known genetic, simplicity, and capacity to accommodate many foreign protein, Escherichia coli remains the most widely used in the production of recombinant proteins. But, overproduction of protein may lead to the formation of inclusion bodies and proteolytic degradation. These problems can be overcome by using protease-deficient strain and protein secretion into periplasmic space. The objective of this research is to secrete recombinant HA on E. coli BL21(DE3) using TorA signal peptide and proved using SDS-PAGE. This research method begins with the preparation of competent cell and transformation of E. coli BL21(DE3), expression of recombinant HA in E. coli BL21(DE3), and characterization of expression result by using SDS-PAGE. The result of this study was rHSA can be secreted into extracellular medium using TorA signal peptide with a molecular weight of ± 66.5 kDa.


In this paper, we examine student perceptions of different delivery modalities used in two sections of a course in machine component design. This is an undergraduate course required for mechanical engineering and engineering technology students. The goal of this study is to investigate how an instructor's chosen pedagogy relates to a student's perception of a course, within the context of a polytechnic institution. Students in two sections of the course, taught by two different instructors, were surveyed using both qualitative and quantitative questions to compare between two pedagogical approaches. One approach utilized open-ended problem solving and another focused more on structured lecture and laboratory activities. The results suggest that student perceptions of the polytechnic nature of a class did not significantly differ between the two pedagogical approaches. Students found each class to be representative of a polytechnic nature because hands-on, physical labs were utilized. It did not matter if the lab activities were open-ended or structured. This aligned with the students' definition of what polytechnic education means: "hands-on".


Effective academic advising is recognized as key to college student success and academic retention (Pascarella & Terenzini, 1991; Mastrodicasa, 2001). There are at least seven different structural models for academic advising; each depends to a greater or lesser degree on a level of engagement by faculty in the process (Kramer, 2003). Despite devoting large amounts of resources toward improving academic advising, many institutions find a less than adequate level of engagement is achieved. Based on a review of recent studies, including data from a national study of faculty recently completed, the author identifies six key threats to engagement. These include: institutional role competitiveness, increasing faculty workloads, inadequate advisor training and preparation, legal concerns, technological barriers, and escalating levels of challenge presented by students and their parents. As a whole, these threats add up to a system of institutional disincentives that prevent full participation by faculty in academic advising in many higher education settings. The author shows how to turn these challenges into opportunities, by illustrating the recent success story of one higher education institution whose students took the lead to demand – and receive – significant institutional improvements in academic advising. Culture of Engagement 3


Background Radioimmunotherapy (RIT) has been used to treat relapsed/refractory CD20+ Non-Hodgkin lymphoma (NHL). Myeloablative anti-CD20 RIT followed by autologous stem cell infusion (ASCT) enables high radiation doses to lymphoma sites. We performed a phase I/II trial to assess feasibility and survival. Methods Twenty-three patients with relapsed/refractory NHL without complete remission (CR) to salvage chemotherapy were enrolled to evaluate RIT with Iodine-131 labelled rituximab (131I-rituximab) in a myeloablative setting. Biodistribution and dosimetric studies were performed to determine 131I activity required to induce a total body dose of 21-27Gy to critical organs. In 6/23 patients RIT was combined with high-dose chemotherapy. 8/23 patients received a sequential high-dose chemotherapy with a second ASCT. The median follow-up is 9.5 years. Results 6.956-19.425GBq of 131I was delivered to achieve the limiting organ dose to lungs or kidneys. No grade III/IV non-hematologic toxicity was seen with RIT alone. Significant grade III/IV toxicity (mucositis, fever, infection, one therapy related death) was observed in patients treated with RIT combined with high-dose chemotherapy. The overall response rate was 87% (64% CR). The median progression-free (PFS) and overall survival (OS) is 47.5 and 101.5 months. An international prognostic index score >1 was predictive for OS. Conclusion Myeloablative RIT with 131I-rituximab followed by ASCT is feasible, well-tolerated and effective in high risk CD20+ NHL. Combination of RIT and high-dose chemotherapy increased toxicity significantly. Long-term results for PFS and OS are encouraging.


The policy makers or lawyers may face the need of legal research for reasons. The congressmen may plan to make new laws to address the challenges of their constituent or to the interest of nation. The lawyers may need to serve their clients who like to know the legal issues involved, the strategies to deal with their loss and recovery, and prospect for winning the case if the dispute has gotten worse. The lawyers may practice in a solo business or might work as an associate lawyer in the law firms. A senior lawyer or partner in some cases may like to exploit the junior work force about the problems or grievances from the potential clients. Since he needs to focus their attention on other matters, such as the business expansion of his law firm or more lucrative cases in need of career hands, he may tap the junior lawyer for the legal research, who could assist with the basis of his final legal opinion. The memorandum, opinion letter and brief would be such forms of professional communication for the lawyers and legal researchers. The congressman also can be supplemented with the aid of staffs in terms of his legal expertise and grasp of the issues standing for carrying their responsibility more effectively. For the lawyers and legal researchers, the structure of state and federal legal system is the kind of important variants to orient their work direction and basic frame for the most efficient and adequate scope of search and analysis. The paradigm change also is revolutionary to impact the general base of people. Decades ago, the research or researcher only related with the class of professionals, such as professors, lawyers, career officers and cadres of enterprises. They would enjoy insulation and exploit their research work as an entrance barrier from lay people. Their large shelves at home study or in the room or corner of office thrust an impression that he or she is learned and knowledgeable. This impliedly communicates his or her prestige of social or professional success. The books and articles seem to symbolize a kind of monopoly which bears to exclude unclassified or non-professional workers. The change is remarkable that every citizen could benefit from the on-line sources of information, which, of course, is generally true of professional knowledge. Now professors fear of plagiarism that students often are the kind of suspect. The legal research would turn on the help of digitization which revolutionizes to incur a new mode of research operation. About the query, the citizens and people can readily verify its truth or falsity with one clique within the personal computer. An enormous amount of information is currently flowing on the internet and on-line sources of reference, which shapes an informative and knowledgeable society. As the medical doctors warned decades ago, the precept is any most effective, "forbear from your intelligence or knowledge work for your health." Many of them now spend long hours a day to satisfy their curiosity and intelligent search. He or she may be well awarded an academic degree if to recognize their hard work on his PC. Nevertheless, this information age does not always bring a positive progress, which arouses the kind of issues, say, right of privacy, on-line fraud. In some cases, this transformation may lead to an inferior attitude of researcher. My today's experience is one of exotic case. I have received an e-mail from Google CEO stating that I have been selected as one of twelve winners from the pool of Google users. The award money is enormous which stalls me for some time. The authenticity and reliability have hit my head, and I utilized a verification service website managed by the team of lawyers. It costs five dollars and remaining 24 dollars would be processed upon the progress of interaction. I am waiting for an answer from the team. Then the research nowadays is not limited to the basic context of our subsistence, but influences in any depth into the professional lives.


A set of reliable floating-point arithmetic algorithms for Berger encoded operands is presented. Closed-form equations are derived for floating-point addition, subtraction, multiplication and division. Given the IEEE floating-point number standard, the redundancy requirements of the proposed scheme are 39.47% for addition/subtraction, 45.65% for multiplication, and 45.44% for division of single precision numbers. The scheme uses only 16.14% for addition/subtraction, 36.44% for multiplication and 36.02% for division of double-precision numbers.<<ETX>>


Terahertz imaging detectors implemented in a 65-nm CMOS SOI technology are presented. Low-noise square-law power detection is provided by distributed self-mixing in NFET-based passive mixers with optional integrated amplifiers. The pixels of the imaging array are equipped with folded-dipole antennas designed for through-substrate illumination by an integrated silicon lens. With front-side illumination and conductor backing of the chip a maximum non-amplified responsivity (Rv) of 1.1 kV/W and a minimum noise-equivalent power (NEP) of pW/√Hz is achieved. In the intended lens-integrated backside illumination configuration a further 8-dB improvement of Rv and NEP due to the elimination of substrate modes is predicted by EM simulations.


Cistus ladanifer L. (Cistaceae) is a shrubby species, primarily found as a dominant species of the Mediterranean evergreen scrub. Intervarietal (var. ladanifer and var. maculatus) cross compatibility and self-incompatibility (SI) were studied in six Iberian populations of C. ladanifer. In addition, temporal variation in SI across 2 years and variability in the strength of SI throughout the flowering season were analysed in a subset of two populations. The two coloured floral morphs of C. ladanifer were compatible, and pollination had statistically similar ability to fruit set when crossing individuals of the two varieties (440 flowers). Results from hand self-pollination indicate negative self-compatibility, regardless of individuals being sampled from different populations, varieties and years (160 flowers in 2003 and 1620 flowers in 2006). In addition, SI strength did not vary along the flowering season. All these results lead us to argue that, in contrast to the results of its sister species (Cistus salviifolius), the highly polymorphic C. ladanifer possesses an extremely stable SI system but a weak reproductive barrier between varieties.


The low energy decay rates of four-and five dimensional dyonic black holes in string theory are equivalently described in terms of an effective near horizon AdS 3 (BTZ) black hole. It is then argued that AdS 3 gravity provides an universal microscopic description of the low energy dynamics these black holes.


The spontaneous emission and optical gain spectra from an InGaAs quantum dot laser have been independently measured under the same operating conditions. Using these spectra a combined probability-distribution function describing the electron occupancy in the conduction and valence bands has been experimentally determined. Comparison of this function with theoretical curves based on Fermi-Dirac statistics shows that for temperatures down to 100 K the carrier occupancy statistics are accurately described by thermal distributions. Measurements at 70 K show a breakdown of thermodynamic equilibrium indicated by non-thermal carrier distributions.


The present invention relates to a hydrophobic, fumed silica which is obtained by reacting fumed silicas with cyclic polysiloxanes of the type-[0-SiR]-, where R is a Cto Calkyl group and n is 3 to 9, and subsequently milling the silanized silicas obtained, and to a process for the preparation of the silica according to the invention, and to silicone rubber materials containing the silica according to the invention.


The article offers a theoretical analysis of the advantages and contradictions of innovative changes in modern education. The author uses the data presented in the UNESCO and Council of Europe programmes, reviews in the main areas of innovative development, but also information from the websites of international organizations, implementing innovative educational models. The ideas of lifelong learning, inclusion and open education in the 2010s are meanwhile developing in conditions of "liquid modernity" (Bauman, 2000). Metamodern culture, the capitalization of knowledge, digitalization and network socialization are presented as the main external sources of the innovative boom in the education world of the 2010s. Against the background of the technological development one can see serious risks of forcing the humanitarian values and basic foundations out of pedagogic processes. In this regard, the need for constant critical reflection on the results of innovative education changes is emphasized.


The subject of this thesis is dynamics of plates with thin piezoelectric layers. Piezoelectric materials are often used in sensors and actuators and common applications for these are vibration control and ultrasonic transducers. In the first part of the thesis plate equations for a plate consisting of one anisotropic elastic layer and one piezoelectric layer with an applied electric voltage are derived. The displacements and the electric potential are expanded in power series in the thickness coordinate, which leads to recursion relations among the expansion functions. Using these in the boundary and interface conditions, a set of equations is obtained for some of the lowest-order expansion functions. This set is reduced to a system of six plate equations, where three of them are given to linear order in the thickness and correspond to the symmetric (in plane) motion, while the other three are given to quadratic order in the thickness and correspond to the antisymmetric (bending) motion. In principle it is possible to go to any order and it is believed that the equations are asymptotically correct. Some numerical comparisons are made with exact theory for infinite plates and very good agreement is obtained for low frequencies. In the second part of the thesis the plate equations are evaluated by investigating a vibration problem with a finite elastic layer and a shorter piezoelectric layer on top of it. The boundary conditions to combine with the plate equations are derived by inserting the power series expansions into the physical boundary conditions at the sides of the elastic layer and identifying equal powers of the thickness coordinate. Numerical comparisons of the displacement field are made with two other theories. The first one is another approximate theory based on the same type of power series expansions, where the piezoelectric layer is modeled as equivalent boundary conditions. The other one is exact three-dimensional theory. Both approximate theories yield accurate results for thin plates and low frequencies as long as the piezoelectric layer is thin in comparison to the total plate thickness.


In the article statistical analysis of the results of experimental investigation blank forming during broach with rolling in combined anvils includes checking the reproducibility of experiments by Cochran, ANOVA (analysis of variance) based on Fisher's exact test and the determination of measurement error smartly is performed. Experimental materials were six lead samples, consisting of two halves with the applied coordinate grid. The graphic dependences of geometric characteristics from the rotation angle of the blank and percent reduction are obtained and analyzed, intervals varying of the researched parameters are defined. Variation intervals of investigated parameters within which the quality of the deformed samples will meet the requirements are determined and shown on th graphics. Unvaried analysis of variance based on Fisher criterion showed that investigated variable parameters of broach modes (the tilting angle, the value of of compression and the amount of reduction) have a significant influence on the forming of the prototypes. The optimal regimes of deformation of blanks during broaching with rolling in combined strikers with different values of reduction and rotation angle of the blanks around the longitudinal axis from the point of view of achieving the best geometric characteristics of the cross-section of the forging are determined


As ancient as Homer's lines on the shield of Achilles and as recent as John Ashbery's "Self-Portrait in a Convex Mirror," ekphrasis is the art of describing works of art. Over the ages its practitioners have created a museum of words about real and imaginary paintings and sculptures - a museum that James Heffernan explores in this book. Profoundly ambivalent, ekphrastic poetry celebrates the power of the image even as it tries to circumscribe that power with the authority of the word. This contest is typically gendered: the voice of male speech striving to control a female image that is both alluring and threatening, male narrative seeking to overcome the fixating impact of beauty poised in space. Moving from the epics of Homer, Virgil, and Dante to contemporary American poetry, this book presents a history of struggle between rival systems of representation. Heffernan also shows how this struggle changes. Poets ranging from Ovid to Shakespeare use verbalized depictions of rape to show the violence men do under the "colour" of their words; romantic poetry at once salutes and questions the transcendent beauty of visual art preserved in the newly born public museum. In the modern and postmodern eras, poets contend with all the words generated by museums themselves to regulate our experience of visual art.


Background 3 years after a permanent sterile osteosynthesis implants store was created and faced with an increasingly busy surgical unit, changes in surgical practice and the arrival of new healthcare staff, it seemed essential to us to reorganise this stock. Purpose To respond to the needs of the surgical unit team for sterile osteosynthesis implants (SOI). Materials and methods The store was reorganised in 4 steps: Assessment of the number of SOI held in stock and the number used over the last 12 months Categorisation of the implants according to their turnover rate (TR): (TR = the number of implants used in a year/ (12 x the number of these implants in stock) (number of times that a SOI is used monthly) 0≤TR <0.176: class A = SOI with low turnover - > stock reduction 0.176≤TR <0.353: class B = SOI with medium turnover - > unchanged stock TR≥: class C = SOI with greater turnover - > stock increased Calculation of a proposal for a new store based on an ideal TR = 0.26 Discussion about the proposal with the surgeons. Results The permanent store holds 384 items covering 2300 SOI. The classes A, B and C respectively contain: 367, 11 and 6 items, that means 2092 SOI in class A, 128 in class B and 80 in class C. Regarding class A, the number of SOI decreased in 77.6% of the items (924 SOI were counted after optimisation). 144 items have been deleted. With reference to class B, 18.2% of the store remains unchanged (139 SOI in this class after optimisation). An increase in SOI has been reported for 50% of the class C items (87 SOI after optimisation). Thanks to the TR, a stock proposal has been formulated, optimised and approved with the surgeons. Conclusions This reorganisation was possible because the osteosynthesis implants were sterile. This optimisation of the permanent sterile osteosynthesis implants store allowed us to reduce our store by half (from 2300 to 1150 SOI). We also made a contract for the new store with the surgical unit team enabling us to improve the safety of osteosynthesis implants system. No conflict of interest.


In this paper, we introduce Symplectic ODE-Net (SymODEN), a deep learning framework which can infer the dynamics of a physical system, given by an ordinary differential equation (ODE), from observed state trajectories. To achieve better generalization with fewer training samples, SymODEN incorporates appropriate inductive bias by designing the associated computation graph in a physics-informed manner. In particular, we enforce Hamiltonian dynamics with control to learn the underlying dynamics in a transparent way, which can then be leveraged to draw insight about relevant physical aspects of the system, such as mass and potential energy. In addition, we propose a parametrization which can enforce this Hamiltonian formalism even when the generalized coordinate data is embedded in a high-dimensional space or we can only access velocity data instead of generalized momentum. This framework, by offering interpretable, physically-consistent models for physical systems, opens up new possibilities for synthesizing model-based control strategies.


We expose the predominant diffusional pathways for In and As in InAs, as well as dopant Si atoms in InAs, using Nudged Elastic Band calculations in conjunction with accurate Density Functional Theory calculations of the energy of defective systems. Our results show that As is a very fast diffuser compared to In and Si for both vacancy-assisted and interstitially mediated mechanisms. Larger indium atoms, on the other hand, are very slow diffusers and strongly prefer to remain on the In sublattice. Silicon also prefers to stay in substitutional sites in the In sublattice, in agreement with the fact that Si is used to create n-doped InAs. We find that the mechanism by which Si diffuses within the InAs lattice is very unlikely to proceed via vacancy-assisted jumps, since these routes encounter energy barriers above 2 eV. In contrast, silicon can readily make interstitial jumps since they occur with energy barriers as small as 0.23 eV. This suggests that an interstitial diffusion mechanism is strongly preferred for Si diffusion in InAs which challenges the common presumption made for another similar III-V compound, namely GaAs, that Si diffusion takes place via a vacancy-assisted mechanism.


Modern vehicles are increasingly equipped with more sensors which are connected to control units through cables for transmitting crucial real-time sensing data. To reduce the complexity and cost brought to the automotive design and production by the sensor wiring harness, replacing cables with wireless links has been proposed in [1]. With its fine capability of solving multi-path fading and interference resilience, as well as its freely available spectrum, the ultra-wideband (UWB) technology is considered as a highly promising candidate for such intra-vehicle wireless network. For the purpose of evaluating UWB based sensor network, compared with wired system, from the aspects of performance and reliability in transmitting automotive sensing data, an UWB communication testbed is needed. In this paper we present our first attempt in building an intra-vehicle UWB wireless sensor network to transmit automotive speed data from four wheel speed sensors to the electronic control unit (ECU)1. Assembly of the testbed consists of ABS motor control simulating system, wheel speed sensors, UWB transmitting nodes and the UWB network coordinator interfacing with ECU. The paper also includes the description of the main testbed software modules and the report of initial measurement result. Future measurement plan and further work needed to improve the testbed are discussed in the conclusion section.


Isozyme analysis of mMDH in Crithidia asclepii and C. oncopelti by means of electrophoresis and densimetry method suggests the diploidness and genetic exchange in these organisms. Synthesis of mMDH in C. asclepii is checked by duplicated polymorphic loci MDH-1 and MDH-2, each with two alleles. In C. oncopelti two "daughter" loci are functioning too, polymorphic MDH-1 with 3 alleles and monomorphic MDG-2. Resemblance and differences in the isozyme spectra of mMDH can be used for taxonomic purposes.


LD slag (Linz Donawitz slag) is one of the major industrial by-products generated during steel making in the integrated Tata Steel plant at Jamshedpur, Jharkhand, India. The plant uses approximately 25 million tons of iron ore and coal/coke blend every year to produce about 10 million tons of steel. Hot metal or molten iron from the blast furnace is transferred into vessels called torpedoes and transported on rail tracks to the LD shops. Here, the molten iron is refined into steel using the 'basic oxygen furnace' (BOF) method. In a steel industry, all the three types of waste materials (gaseous, liquid and solid) are generated. The generation of gaseous waste material is the highest, but the management of solid waste material is the most intricate. The steel slag generated from LD converter (steel making) is dumped in pits and allowed to cool by sprinkling water. The solidified steel slag is then sent to a waste recycling plant (WRP) for recovery of the metallic and non-metallic portions. The quantity of non-metallic portion of (-6.0mm) LD Slag fines after the recovery of metallic portion is around 40000MT/Month, which is close to 5 Lakh tons per annum. The present study aims at value addition of this enormous amount of non-metallic slag by a chemical process to obtain "yellow gypsum", which has a wide range of industrial and agricultural applications. The authors have characterized this material using techniques such as x-ray diffraction (XRD), chemical analysis, scanning electron microscopy (SEM), thermogravimetric analysis (TGA), Fourier transform infrared analysis (FTIR), and Raman spectroscopy. The authors have also discussed the applicability of this material for different applications. An Indian patent application (572/KOL/2014) has been filed for this material.


This chapter describes the mechanical function of the
cochlea, or inner ear, the organ that converts signals
from acoustical to neural.
Many cochlear hearing disorders are still not well
understood. If systematic progress is to be made
in improved diagnostics and treatment of these disorders,
a clear understanding of basic principles is essential.
Models of the cochlea are useful because they succinctly
describe auditory perception principles.

Several topics will be reviewed. First, the history of cochlear
models, including extensions that have taken place in recent years.
These models include both macromechanics and micromechanics of the
tectorial membrane and hair cells. This leads to comparisons of the
basilar membrane, hair cell, and neural frequency tuning.
The role of nonlinear mechanics and dynamic range are covered
to help the student understand the importance of modern wideband
dynamic range compression hearing aids.
Hearing loss, loudness recruitment, as well as other important
topics of modern hearing health care, are briefly discussed.


There are provided a communication type information distribution system, an information distribution server, and a program capable of assuring profitability considering the cost required for creating a content to be provided to a mobile terminal and protecting the copyright. The information distribution server (40) provides a content menu to the mobile terminal (20) and links to a content server (50) by referencing the content link destination database according to the content specification from the mobile terminal (20). The content server (50) requests a charging server (60) to performs settlement processing, obtains settlement approval, and distributes download information to the information distribution server. The information distribution server enables download of the specified content data from the content server to the mobile terminal by a download control unit. The mobile terminal adds a time stamp based on the system clock to the content data downloaded and compares the current time of the system clock to the time stamp, thereby controlling the use period. ® KIPO & WIPO 2007


This work deals with the biological activity of the essential oils of an Algerian plant (Cotula cinerea) which belongs to the Asteraceae family. The study was carried out in the south-west of Algeria. We chose essential oils which are natural substances thanks to their numerous anti-infectious, antioxidant and antibacterial properties, etc. The objective of this work is to study the acute toxicity as well as the evaluation of the anti-inflammatory properties of the essential oils of both organs (leaves and flowers) of Cotula cinerea. As methodological approaches, we used the hydrodistillation technique to obtain the essential oils from leaves and flowers. Thus, the acute toxicity was determined by Lorke's method and the anti-inflammatory activity was evaluated by measuring the plantar oedema of mice induced by carrageenan. The results show that the essential oil extracts of the leaves and flowers are low toxic substances with LD50s of 1131.37 mg/kg and 1264.91 mg/kg respectively. They also show a considerable anti-inflammatory effect at doses not exceeding 300 mg/kg with maximum percentages of 86.16% for leaves and 80.87% for flowers. These results show the efficacy of the essential oils of this plant and their therapeutic richness which can be used in traditional medicine for anti-inflammatory treatment. This study has provided additional knowledge on the biological activity of Cotula cinerea essential oils and has opened perspectives for the research of the active principles contained in this species as well as the application of biotechnology to know the molecular mechanism and valorise this natural wealth.


BACKGROUND
Increased serum tryptase has been linked to the severity of the reaction after Hymenoptera stings. The aim of the study was to measure basal tryptase levels in patients with Hymenoptera venom allergy and investigate the possible correlation between these levels and the severity of sting reaction.

METHODS
One hundred nine patients were included in the study. Sixty-three were wasp venom-allergic and 46 were honey bee venom-allergic. Basal serum tryptase levels were measured by UniCAP.

RESULTS
Basal serum tryptase levels were elevated in 12 (11%) of the 109 patients. Levels were 5.14 pg/L (3.62-5.84), 5.3 microg/L (2.94-6.54), 5.18 microg/L (3.71-6.25), and 6.98 microg/L (4.78-12.6), for patients with sting reactions of grade I, II, III and IV (as classified by Mueller), respectively. Basal serum tryptase levels correlated significantly with the sting reaction severity (r = 0.2752; P = .004) and with age (r = 0.2906; P = .002). Sting reaction severity also correlated with age (r = 0.3654; P = .001).

CONCLUSIONS
Basal serum tryptase levels were found to be elevated in 11% of venom allergic patients and correlated significantly with both sting reaction severity and age.


Commuting is an important property in many cases of investigation of properties of operators as well as in various applications, especially in quantum physics. In this paper we show that the generalized weighted $k$-th differential operator and weighted Hardy's averaging operator commute on the space of all positive real Lebesgue integrable functions defined on the positive half-line. Using this result we give a number of new and interesting identities involving some functions of mathematical physics.


In this paper, we have analyzed the performance characteristics of OFDM data transmission with regard to a new high speed RS decoding algorithm. The various characteristics identified are mainly speed and accuracy of the transmission irrespective of channel behaviour. We consider two cases viz. data transmission without error control and data transmission with error control. Each of these cases are duly analyzed and it is proven that high speed RS decoding algorithms can actually benefit OFDM data transmission for advanced communication systems only if implemented at the hardware (VLSI) level because of significant processing overhead involved in software based implementation even though the algorithm may have lower computational complexity.


The objective of this study was to investigate the effect of oral administration of artesunate on the histology of the testis in wistar rats. Adult male wistar rats used in the study were divided into 3 groups: Group A received 4mg/kg b.w of artesunate daily for 3 days followed by 2mg/kg b.w daily for next for 4 days; group B received 8mg/kg/kg b.w of artesunate daily for 3 days followed by 4mg/kg b.w daily for next 4 days and group C were given only distilled water and served as control. The rats were fed with grower's mash purchased from Edo feeds and Flour Mill Ltd, Ewu, Edo state and were given water ad libitum. On day eight of the experiment, the rats were weighed and sacrificed by cervical dislocation. The testes were carefully dissected out and quickly fixed in 10% formal saline for routine histological study after H&E method. The histological findings indicated that the treated sections of the testes showed mild sloughing of germ cells from the basement membrane and varying degrees of reduced population of germ cells. These findings suggest that artesunate at normal dose has a deleterious effect on the histology of the testis and could be a potential male antiferftility agent. It is therefore recommended that further studies aimed at corroborating these observations be carried out.


The main objective of this study was to verify the association between the coefficient of parentage estimates and multivariate techniques which were used as measures of genetic diversity in cultivars. Thirty cotton cultivars were used for this purpose among which genetic diversity was estimated by means of the parentage coefficient (CP) and also through multivariate techniques employing microsatellite markers (SSR). The correlation between genetic distances obtained by CPs and SSRs for cultivars was positive and significant, with a value of 0.25. The 18 ancestors evaluated in the current study contributed with 69% to the genetic constitution of the 30 cotton cultivars. The evidence that few ancestors actually contribute to the genetic constitution of the cotton cultivars used in Brazil indicates that new alleles should be introduced into the gene pool of these cultivars in order to broaden the genetic base of cotton.


A 62-year-old man was admitted with increasing palpitations. Radiography of the chest demonstrated a calcified mass. Magnetic resonance imaging revealed compression of the right ventricle by a tumor. At the time of cardiac catheterization, the coronary arteries were found not to supply blood flow of the mass, and no dip-and-plateau pattern was seen in the right ventricular pressure measurements. At the time of surgery, the mass was found to be a focal calcified thickening of the pericardium containing only pus. The thickening resembled an oval pericardial tumor. Microbiologic examination of the pus revealed Propionibacterium acnes.


This article first examines the textual structure of the Okkantika Saṃyutta (no. 25), Uppāda Saṃyutta (no. 26), Kilesa Saṃyutta (no. 27), and Rāhula Saṃyutta (no. 18) of the Pāli Saṃyutta-nikāya in conjunction with their Chinese counterparts in the Saṃyuktāgama (Taishō vol. 2, no. 99). Then it compares the main teachings contained in the two versions. It reveals similarities but also significant differences in both structure and doctrinal content, thus advancing the historical/critical study of early Buddhist doctrine in this area.


Bone marrow or stem cell transplantation is an established therapy for haematological malignancies. We report a cytomegalovirus (CMV) IgG +ve 56‐year‐old patient who underwent autologous rescue with CD34+ selected peripheral blood stem cells as part of consolidation therapy for multiple myeloma and subsequently developed CMV colitis. In contrast to infection secondary to human immunodeficiency virus (HIV), CMV colitis has not previously been described in this context. We discuss this case and issues arising from it related to the use of CD34+ selected stem cells for transplantation.


Multiparametric MRI (MP-MRI) has been widely used for detection of Prostate Cancer (PCa). In this study, we propose a new method using MP-MRI including T2-weighted (T2W) and dynamic contrast enhanced (DCE-) MRI for detection of PCa. 32 patients who had high prostate specific antigen (PSA) level recruited. We generated predictive models by extracting radiomics features and classifying benign and malignant lesions. The feature scores are evaluated with Relieff feature selection for each of the modalities. The fused classifier using decision template method showed the highest performance with accuracy, specificity, and sensitivity of 100.


Incidence of meningococcal disease was associated with socioeconomic deprivation across a rural English region. In young children the incidence was twice as high in the most deprived compared with the least deprived electoral wards. By addressing social inequalities the incidence of this serious infection could be reduced.


Direct inguinal hernias occur in newborn babies, both term and premature. Five cases are reported to illustrate three types of direct hernia. The first is a direct weakness without associated significant indirect hernial sac; the second, a sliding direct hernia. The third might be called a 'secondary' direct weakness resulting from a primarily indirect hernia which assumes such large size and develops such a wide neck at the internal ring that the posterior wall of the inguinal canal is stretched and weakened. This is most likely to occur in very low birthweight babies, who develop giant inguinoscrotal hernias. Full exploration and repair of the posterior wall of the inguinal canal should be performed in such babies with huge indirect hernial sacs and in all babies where the size of the processus vaginalis identified at the internal ring is not consistent with the hernial swelling identified clinically. Repair should be performed in conventional manner with non-absorbable sutures reinforcing the transversalis fascia. Overlying Bassini repair with or without Tanner's slide can be performed. The repair should be carried out before the baby leaves a high dependency area.


Currently, salience-based channel pruning makes continuous breakthroughs in network compression. In the realization, the salience mechanism is used as a metric of channel salience to guide pruning. Therefore, salience-based channel pruning can dynamically adjust the channel width at run-time, which provides a flexible pruning scheme. However, there are two problems emerging: a gating function is often needed to truncate the specific salience entries to zero, which destabilizes the forward propagation; dynamic architecture brings more cost for indexing in inference which bottlenecks the inference speed. In this paper, we propose a Progressive Channel-Shrinking (PCS) method to compress the selected salience entries at run-time instead of roughly approximating them to zero. We also propose a Running Shrinking Policy to provide a testing-static pruning scheme that can reduce the memory access cost for filter indexing. We evaluate our method on ImageNet and CIFAR10 datasets over two prevalent networks: ResNet and VGG, and demonstrate that our PCS outperforms all baselines and achieves state-of-the-art in terms of compression-performance tradeoff. Moreover, we observe a significant and practical acceleration of inference.


INTRODUCTION: Assess baseline and follow up safety culture data as well as outcome metrics on a Labor and Delivery Unit after the initiation of a patient safety program. METHODS: The Safety Attitudes Questionnaire (SAQ) has been widely validated in healthcare. This survey was distributed and collected from all professionals who work on the unit at the start of the intervention and fifteen months after; changes were assessed with the student t test. Clinical outcome measures were reviewed 12 months before initiation of the program and 15 months after using the chi-squared test. Twice-daily interdisciplinary safety huddles were initiated to discuss patients in active labor, high acuity antepartum, and postpartum patients. Four nursing centered teamwork-training sessions reviewed TeamSTEPPS principles, medication safety, and emergency scenarios. The Olive View Medical Center Institutional Review Board approved the study (#14E-LC1001). RESULTS: A total of 144 surveys were completed, 68 before and 76 after the intervention. Safety (P=.02), error management (P=.04), and safety practices (P=.03) demonstrated the most improvement overall. OB faculty also reported improvement in interactions with nursing (P=.02) and safety practices (P=.02). Other areas of improvement were L&D RN and OB faculty job satisfaction (P=.06 and .08), teamwork culture overall (P=.06); overall interactions with nursing (P=.06). No L&D outcome measures collected over the 26 month period demonstrated significant change. CONCLUSION: This study demonstrates that targeted improvements can make a difference in overall safety culture particularly in areas around safety, management of errors, and safety practices, but even extending to staff perceptions of job satisfaction and working conditions.


Health care is usually thought of as a basic right of each individual. This so-called basic right is denied to many mainly because of their economic situation and the color of their skin. There is a need for more blacks, Indians, Mexican-Americans, Puerto Ricans, and Asians in the health care field. The numbers are low and the training process slow. Time is needed to prepare ethnic people of color. Since most of the deliveries of health care are white, these white workers must become sensitive to the traditions, values and attitudes of the ethnic groups of color. Schools of nursing are beginning to include cultural differences in nursing curriculums, but the majority of the nurses who practice are not aware of and are not sensitive to the needs of nonwhite patients. Nursing must help solve problems of the ethnic groups of color. Nurses must become personally involved in the injustices of health care. As Marie Branch states, there must be "personal reeducation." When this occurs, health care to the minority client will improve.


The small-angle neutron-scattering pattern from bundles of 3 μm diameter porous alumina fibres has been determined and found to be anisometric. Intense scattering at a narrow divergent angle has been observed perpendicular to the fibre axes, coupled with a lower-intensity scattering over all other angles. The pattern has been analysed by means of sector analysis in order to determine the variation of intensity with modulus of the scattering vector over the range 0.006–0.2 A−1. A theory has been developed to account for contributions to scattering from, firstly, macroscopic features of the fibres such as alignment distribution and lack of straightness and, secondly, from internal porosity allowing for distributions of size and of orientation with respect to the fibre axis. The parameters of the size distributions have been estimated from the two-dimensional data by directly fitting the scattering equations using a weighted non-negative least-squares principle.


Background & objectives: Achievement on improving nursing care quality has always been considered by administrators. "Improving the productivity of clinical staffs' law" has been adopted to address nurses' problems and providing better services to the patients. This study aimed to investigate the situation of this law enforcement. Methods: The study population is all the administrators and clinical staffs employed in 4 hospitals affiliated to Ardabil University of Medical Sciences. The subjects were selected by both census (for administrators; n=52) and simple random sampling (for clinical staffs: n=300) methods. Data were collection using a researcher made questionnaire. Data collection tools reliability and validity were evaluated through content validity and test–re-test method, respectively. Data analysis was done using descriptive statistics and spearman, Mann-Whitney & Kruskal-Wallis tests. Results: Mean attitude scores among administrators and clinical staffs were 3.27±0.70 and 3.35±0.64, respectively. Among the factors affecting attitude, improving working conditions (3.48±1.00) in perspective of managers and increasing the quality of services (3.45±0.87) in perspective of clinical staffs were the most important factors on creating a positive attitude. The most important weakness of the law enforcement in perspective of both staffs and administrators was shortage of clinical staffs. Clinical staffs' age, sex, marital status, employment history, education level, and type of employment had significant relationships with the attitude and satisfaction scores (p< 0.05). Conclusion: Enforcement of "improving productivity of clinical staffs' law" has had advantages for the majority of clinical staffs and it can resolve many of their concerns subject to modification made in employment system, improving work conditions based on the needs, and implementing incentive programs. It can also be effective on improving productivity of nurses and thereby improves the health system.


There is a numerical procedure for modeling autofrettage of thick-walled cylinders that incorporates the Bauschinger effect as a function of prior plastic strain and Von Mises' yield criterion. In this paper the numerical procedure is extended to solve the analogous problem of a spherical, thick walled steel vessel. An equivalent new analytical solution for the case of a spherical vessel is also formulated. The analytical and numerical solutions are shown to be in close agreement. It is demonstrated numerically that a reautofrettage procedure, previously proposed for cylindrical vessels, may be extremely beneficial for spherical vessels. Additional commentary is provided on the limitations of certain analytic solutions.


Background Historically, allergic asthma has been considered the background of the development of Churg-Strauss Syndrome (CSS)1,2. Recently, a retrospective study comparing CSS and allergic asthma proved that respiratory atopy or allergy, at least to known and currently tested allergens, are present in approximately only the 30% of CSS patients, compared to near the 60% in patients with allergic asthma3. In the last years, a new family of chemokines, named eotaxins, have increasingly been proved to be a powerful chemotactic agent for eosinophils, inducing the activation and the migration of eosinophil to the inflammation site4. Indeed, an increase in eotaxin levels (though locally or in peripheral blood) has been proved in several eosinophil-mediated diseases (including allergy and CSS)5. Objectives The aim of our study is to focus in the differences and similarities at the immunologic response level between CSS and allergic asthma. In this first part of a wider work, we studied the levels of eotaxin in peripheral blood samples from patients with CSS and allergic asthma. Methods We collected peripheral blood samples from patients with CSS in clinical remission and from a cohort of patients with allergic asthma most of whom presented signs and symptoms of mild to moderate disease activity. We determined the concentration of eotaxin using a cytometric bead array (CBA) assay from BD™ using a monoclonal antibody against human CC chemokine eotaxin. Results We compared eotaxin levels from 19 patients with CSS in clinical remission with a cohort of 9 patients with allergic asthma. Results were as follows: Conclusions Indeed, eotaxin play an important role in both diseases. Nonetheless, in CSS reaches higher levels, probably translating a prominent polarization of the T cell response towards a Th2 profile. Notably, despite lacking clinical evidence of CSS activity, eotaxin levels remain elevated, highlighting the presence of a treatment resistant immunological activity. References Solans R, Bosch JA, Perez-Bocanegra C, Selva A, Huguet P, Alijotas J, et al. Churg-Strauss syndrome: outcome and long-term follow-up of 32 patients. Rheumatology (Oxford) 2001;40(7):763-71 Guillevin L, Cohen P, Gayraud M, Lhote F, Jarrousse B, Casassus P. Churg-Strauss syndrome. Clinical study and long-term follow-up of 96 patients. Medicine (Baltimore) 1999;78(1):26-37 Bottero P, Bonini M, Vecchio F, Grittini A, Patruno GM, Colombo B, et al. The common allergens in the Churg-Strauss syndrome. Allergy 2007;62(11):1288-94 Conroy DM, Williams TJ. Eotaxin and the attraction of eosinophils to the asthmatic lung. Respir Res 2001;2(3):150-6 Polzer K, Karonitsch T, Neumann T, Eger G, Haberler C, Soleiman A, et al. Eotaxin-3 is involved in Churg-Strauss syndrome--a serum marker closely correlating with disease activity. Rheumatology (Oxford) 2008;47(6):804-8 Disclosure of Interest None Declared


We consider a model in which each worker endogenously selects his own type through a private investment decision and selects a public signal in the labor market. Signaling then contributes to social welfare through its influence on the quality choice. We offer a rationale for the argument that there are too many high-type workers from a welfare perspective, identifying circumstances under which separating equilibrium generates too many high-type workers while having to use the incentive-compatible signal and treat high-type workers differently in the market. The inefficiency can then be reduced in pooling equilibrium.


The refolding of denatured proteins with complete sequences may not be fast enough to account for the in vivo folding of growing peptide chains during biosynthesis. As some peptide fragments have secondary structures not unlike those of the corresponding segments in the intact molecules and native disulfide bonds of some proteins can form cotranslationally, it is suggested that the folding of the nascent chain begins early during synthesis. However, further adjustments may be necessary during chain elongation and after posttranslational modifications of the completed peptide chain to generate the native conformation of a biologically active protein.


Rockwell-Collins France has completed during the calendar year 2002 the software development of an IP client for the product line HFMessenger/spl trade/ that is compliant with STANAG5066. STANAG5066 is a new ratified NATO standard that defines a profile for high frequency radio data communications. The key features of this standard are the definition of a selective ARQ mechanism and the use of high performance capabilities (connection layer, adaptive data rate, synchronous high data rate,...). The STANAG5066 Annex F provides a list of top-level applications that can interface to the protocol stack in order to transmit useful data over a reliable High Frequency channel. Among these applications is an IP client. This IP client is a software application that acts basically as an HF router conveying any IP traffic coming from a Local Area Network to another Local Area Network passing through the HF network. The IP client, combined with HFMessenger/spl trade/ software and the high-speed HF modem MDM-Q9600 from Rockwell-Collins, offers a new way to transmit IP traffic over HF.


Trade Unions, Migrant Workers, and Racial Discrimination in Italy in Times of Economic Crisis Trade unions have a crucial role in the social integration processes of migrants. Nevertheless, some aspects of this relationship are still relatively unexplored, particularly that of the relationship between trade unions and racism and that of the trade unions' fight against racial discrimination. This paper aims to investigate the still partially unexplored link between Italian trade unions and racial discrimination within the framework of the 2008 economic crisis. Through the narratives of stakeholders, trade unions, and migrant workers, the author provides an in-depth look at the efforts of Italian trade unions to fight discrimination and examines the main barriers that prevent migrants from being involved in unions.


Consumer demand for healthcare information, including data about the performance of healthcare providers, has increased steadily during the past decade. Many state and national initiatives are under way to mandate or induce healthcare organizations to publicly disclose information regarding institutional and physician performance. Mandatory public reporting of healthcare performance is intended to enable stakeholders, including consumers, to make more informed choices on healthcare issues. Public reporting of healthcare performance information has taken several forms. Healthcare performance reports (report cards and honor rolls) typically describe the outcomes of medical care in terms of mortality, selected complications, or medical errors and, to a lesser extent, economic outcomes. Increasingly, process measures (ie, measurement of adherence to recommended healthcare practices, such as hand hygiene) are being used as an indicator of how well an organization adheres to established standards of practice with the implicit assumption that good processes lead to good healthcare outcomes. National healthcare quality improvement initiatives, notably those of the Joint Commission on the Accreditation of Healthcare Organizations (JCAHO), the Centers for Medicare & Medicaid Services (CMS), and the Hospital Quality Alliance, use process measures in their public reporting initiatives.


Background: Aquagenic wrinkling of the palms (AWP) is a rare condition characterised by the development of oedema and excessive wrinkling of the palms following exposure to water. It has frequently been associated with cystic fibrosis (CF). Early reports of AWP have only been case reports or small case series; there has only been one reported prevalence study of AWP in a CF population. Objective: To determine the incidence and characteristics of AWP in the adult CF population in Northern Ireland. Methods: 105 CF patients were interviewed. The patients were asked whether they noticed excess wrinkling of the hands when exposed to water. If they answered 'yes', further questions were asked regarding clinical characteristics. The atopic status, CF genotype and drug history were recorded for each patient. Formal testing of 7 patients was carried out. Results: Out of the 105 patients who were interviewed, 43 (41%) described AWP. Of the 43 patients with AWP, 20 were male and 23 were female. There was no association of AWP with genotype, atopy or concomitant drug intake. Conclusion: AWP appears to have an equal sex incidence, and the high number of cases in the population studied would suggest that this condition is underreported.


This paper demonstrates three examples of applying remote-sensing technology to the delineation of wetlands in the United States. First, the results of a technique to identify roseau cane (Phragmites communis) using LANDSAT and aircraft MSS data are presented. Approximately 9700 ha. of Phragmites communis were identified in the Mississippi River delta using LANDSAT data. Second, the results of a technique to identify wetland communities, principally mangroves, in Florida using LANDSAT and aircraft MSS are presented. A cost analysis of the remote versus conventional ground-survey technique is provided. The LANDSAT MSS average classification accuracy for mangroves only versus all classes were 87 percent and 74 percent, respectively. The third example presents the results of a technique to delineate surface cover types in the southeast tidal/riverine system of the Savannah River. Both forested and nonforested wetlands were delineated using multi-temporal LANDSAT MSS data. The average classification accuracy for wetland classes only was about 82 percent and for all cover types was about 78 percent.


This book presents carefully selected contributions devoted to the modern perspective of AI research and innovation. This collection covers several areas of applications and motivates new research directions. The theme across all chapters combines several domains of AI research, Computational Intelligence and Machine Intelligence including an introduction to the recent research and models. Each of the subsequent chapters reveals leading edge research and innovative solution that employ AI techniques with an applied perspective. The problems include classification of spatial images, early smoke detection in outdoor space from video images, emergent segmentation from image analysis, intensity modification in images, multi-agent modeling and analysis of stress. They all are novel pieces of work and demonstrate how AI research contributes to solutions for difficult real world problems that benefit the research community, industry and society.


Skin wounds may cause severe financial and social burden due to the difficulties in wound healing. Original inert dressings cannot meet multiple needs in the process of wound healing. Therefore, the development of materials to accelerate healing progress is essential and urgent. In the previous study, we found that the homogeneously synthesized hydroxybutyl chitosan (HBCS) had an effective performance in promoting wound healing. Proteomic analysis of the same specimen suggested that matrix metalloproteinase 23 (MMP23) may play a key role in HBCS expediting the progress of wound healing. In this work, we aim to reveal the underlying mechanism of MMP23 in the dynamic process of cutaneous proliferation and repair period. In order to regulate the expression level of MMP23 in the local wound area, we leaded in adeno-associated virus (AAV) to specifically decreased expression quantity of MMP23 in rat skin. In contrast to the negative control groups, we found that the wound closed faster and the collagen fibers and neovascularization were significantly increased in AAV groups. These findings highlighted that MMP23 was involved in wound healing after traumatic injury, and managing the expression of MMP23 could be a potential intervention target to accelerate wound healing.


Prostaglandins (PG) are studied for their effect on the activity of natural killer cells (NKC) under the tumour growth. The interaction of PG with other regulators of the NKC activity (interferons, interleukins) is considered.


Abstract Recent evidence is focusing on the presence of a hypercoagulable state with development of both venous and arterial thromboembolic complications in patients infected with SARS-CoV-2. The ongoing activation of coagulation related to the severity of the illness is further characterized by thrombotic microangiopathy and endotheliitis. These microangiopathic changes cannot be classified as classical disseminated intravascular coagulation (DIC). In this short review we describe the interaction between coagulation and inflammation with focus on the possible mechanisms that might be involved in SARS-CoV-2 infection associated coagulopathy in the critically ill.


In the COVID-19 outbreak, governments have applied progressive restrictions to production activities, permitting only those that are considered strategic or that provide essential services. This is particularly apparent in countries that have been stricken hard by the virus, with Italy being a major example. Yet we know that companies are not just isolated entities: They organize themselves into intricate shareholding structures --- forming company networks --- distributing decision power and dividends in sophisticated schemes for various purposes.
One tool from the Artificial Intelligence (AI) toolbox that is particularly effective to perform reasoning tasks on domains characterized by many entities highly interconnected with one another is Knowledge Graphs (KG). In this work, we present a visionary opinion and report on ongoing work about the application of Automated Reasoning and Knowledge Graph technology to address the impact of the COVID-19 outbreak on the network of Italian companies and support the application of legal instruments for the protection of strategic companies from takeovers.


An extraordinary event that causes shock can affect volatility which causes asymmetric variance and error or commonly called asimetric shock / effect. This paper aims to analyze the volatility of stock returns of PT ANTAM (Persero) Tbk and PT Adaro Energy Tbk in the period of 2008 to 2016. The research results show that ANTM and ADRO have a GARCH effect and also have a leverage effect where the optimal model is found in the GJR model (0,1,1) for ANTM and GJR (1,1,1) for ADRO. Forecasting results shows that ADRO has higher volatility but in a relatively low percentage of volatility about 0.001 while ANTM have a tendency to decrease volatility with a fairly large percentage of volatility about 0.0025.


Background :Indonesia is number fourth highest Tuberculosis burden country after China, India and South Africa. Now a days, tuberculosis in children is growing rapidly. At least 500,000 children in the world suffer from TB every year. TB is an infectious disease caused by Mycobacterium tubercolosis. Generally, TB attacks lungs, but can spread to other organs in the body. Many factors that can influence TB disease are nutritional status, vaccination and environmental housing condition.
Objective : This research aims to examine the relationship between nutritional status, Bacillus Calmette-Guerin (BCG) vaccination and environmental housing condition with TB in toddlers in Mlati Sleman.
Methods :The type of this study was observational research with case control study match by sex and age design. It was done in June 2015 and located in Mlati.
The subjects of research were 18 toddlers with TB in Mlati I and II clinics. The control sample was collected using purposive random sampling with ratio 1:1 for toddlers who did not suffer from TB. The independent variables were BCG vaccination, nutritional status and environmental housing condition and the dependent variable was TB in toddlers. Data were collected by interviews, measurement and observation of the environmental housing condition of the respondents. The data were analyzed using univariate and bivariat statistical tests (Chi-Square test and OR).
Result : immunization coverage BCG reaches 100%.
Conclusion :There is a relationship of the incidence of TB with the nutritional status of toddlers in Mlati (p < 0.05). The Condition of the home environment include flooring, lighting, windows, toilets, garbage and water are not related to the incidence of TB in Mlati (p
> 0.05).

Keyword: TB in toddlers, nutritional status, BCG vaccination, environment housing condition


Catecholamines mediate their effects in the heart through beta 1- and beta 2-receptors. Beta 1-receptors mediate the effects of sympathetic nerve stimulation. Alpha-receptors may have a role but, unlike the beta-receptor mediated responses, act without producing any increase in cyclic AMP. Prolonged receptor stimulation results in a reduction in beta-receptor sensitivity. In contrast blockade with a non-agonist agent is associated with an increase in catecholamine sensitivity which may be responsible for the withdrawal reactions that can occur when beta-blocking drugs are rapidly withdrawn in patients with ischaemic heart disease. Experimentally, prolonged noradrenaline infusions result in ventricular hypertrophy. Catecholamines have been implicated in several pathologies. High and rising catecholamine levels are associated with worsening of prognosis in patients with heart failure. These patients show a decreased beta-receptor number and cellular concentration of catecholamines. On the other hand cardiomyopathy is associated with an increased sensitivity to catecholamines. Catecholamines aggravate cardiac damage in ischaemia. Excessively high catecholamine loads cause myocardial damage in otherwise normal hearts, for example in patients with a phaeochromocytoma and those with various forms of cerebral damage such as subarachnoid haemorrhage, cerebrovascular accidents, and head injury.


The disturbed homeostasis of the immune system in Obese strain (OS) chickens with spontaneous autoimmune thyroiditis consists in a general T cell hyperreactivity (concanavalin A hyperresponsiveness, interleukin 2 (IL 2) hypersecretion), particularly expressed by those lymphocytes which infiltrate the diseased thyroid gland. This abnormality has been attributed to a defective regulation of both IL 2 production and IL 2 function by low m.w. factors, which are present in serum and splenocyte culture supernatants of normal chickens, but deficient in the OS. In the present study we identified the cellular origin of IL 2 antagonistic activity as a nonlymphoid, adherent cell. Suppressor factor production in vitro was confined to the plastic adherent fraction of spleen cells and preincubation of splenocytes with nylon wool, silica particles, or carbonyl iron significantly reduced the nonspecific suppressive activity of the culture supernatant. Kinetic studies revealed the defect in nonspecific suppression to entail prolonged IL 2 production by concanavalin A-activated OS spleen cells. In vivo treatment of normal White Leghorn chickens with silica led to a decrease in suppressive serum activity down to the OS level, whereas neither neonatal thymectomy nor bursectomy had any effect. The defective suppressor factor production in autoimmune chickens appeared to be due to a functional, but not numeric defect of macrophages as revealed by phenol red staining. The possibility that this aberration in adherent cell function might be a secondary phenomenon to the recently described reduced corticosterone tonus in OS chickens was excluded by in vivo substitution with exogenous glucocorticoids which did not normalize the suppressor defect in serum or in conditioned medium. Finally, we present evidence that T lymphoblasts from OS animals are less susceptible to IL 2 antagonistic regulation than normal cells, which possibly further contributes to the T cell hyperfunction of this autoimmune strain.


Using the deepest 1.2 mm continuum map to date in the Hubble Ultra Deep Field, which was obtained as part of the ALMA Spectroscopic Survey (ASPECS) large program, we measure the cosmic density of dust and implied gas (H2+H i) mass in galaxies as a function of look-back time. We do so by stacking the contribution from all H-band selected galaxies above a given stellar mass in distinct redshift bins, and . At all redshifts, and grow rapidly as M decreases down to 1010 M⊙, but this growth slows down toward lower stellar masses. This flattening implies that at our stellar mass-completeness limits (108 M⊙ and 108.9 M⊙ at z ∼ 0.4 and z ∼ 3), both quantities converge toward the total cosmic dust and gas mass densities in galaxies. The cosmic dust and gas mass densities increase at early cosmic time, peak around z ∼ 2, and decrease by a factor ∼4 and 7, when compared to the density of dust and molecular gas in the local universe, respectively. The contribution of quiescent galaxies (i.e., with little on-going star formation) to the cosmic dust and gas mass densities is minor (≲10%). The redshift evolution of the cosmic gas mass density resembles that of the SFR density, as previously found by CO-based measurements. This confirms that galaxies have relatively constant star formation efficiencies (within a factor ∼2) across cosmic time. Our results also imply that by z ∼ 0, a large fraction (∼90%) of dust formed in galaxies across cosmic time has either been destroyed or ejected to the intergalactic medium.


Symptomatic bradycardia-tachycardia is often a feature of sick sinus syndrome. However, when alternating brady-tachycardia results from excessive use of digitalis preparations or electrolyte imbalance, it is iatrogenic and therefore not considered to be SSS per se. Sick sinus syndrome is applied to the following arrhythmias providing they are not iatrogenically induced: (1) sinus bradycardia usually unresponsive to atropine therapy or exercise, (2) sino-atrial block or arrest with long pauses, and (3) alternating bradycardia or tachycardia.


As an important link during the whole operation process of acupuncture, it is very necessary to launch quantity study closely related to acupuncture finger force in the acupuncture quantity study. After retrieval of related literatures on finger force during acupuncture in recent 20 years, it was found out that although some exploration on acupuncture finger force had been made, it was scattered and had no deep research, which pointed out it was a weak link in the acupuncture quantity study. So study of finger force should be paid attention to in acupuncture-moxibustion field, the level of theoretical and experimental research and development of measuring instrument on acupuncture finger force should be strengthened, the application of instrument should be expanded in teaching and scientific research areas, which could promote the modernization and internationalization of acupuncture and moxibustion better and faster.


Chylopericardium is a clinical condition due to the accumulation of triglyceride-rich chylous fluid within the pericardial space. It may be primary (idiopathic), without any apparent cause or secondary to some precipitating factors, such as cardiac surgery, malignancy, trauma, infection and radiation. Primary chylopericardium is rare and a diagnosis of exclusion, so far less than 150 cases have been reported in the literature. The authors present a case of recurrent primary chylopericardium diagnosed by lymphoscintigraphy.


Aqueous zinc ion batteries have gained research attention as a safer, economical and more environmentally friendly alternative to lithium‐ion batteries. Similar to lithium batteries, intercalation processes play an important role in the charge storage behaviour of aqueous zinc ion batteries, with the pre‐intercalation of guest species in the cathode being also employed as a strategy to improve battery performance. In view of this, proving hypothesized mechanisms of intercalation, as well as rigorously characterizing intercalation processes in aqueous zinc ion batteries is crucial to achieve advances in battery performance. This review aims to evaluate the range of techniques commonly used to characterize intercalation in aqueous zinc ion battery cathodes, providing a perspective on the approaches that can be utilized to rigorously understand such intercalation processes.


MUC1 is highly expressed in multiple tumor histologies and is hypoglycosylated relative to normal tissue, with prematurely terminated carbohydrate modifications including αN-acetylgalactosamine (Tn). The aberrant glycosylation state of MUC1 makes this antigen immunologically distinct in tumor relative to normal tissues and an attractive vaccine target. ONT-10 is a liposomal formulated vaccine that incorporates a synthetic glycopeptide antigen that includes two complete 20 amino acid tandem repeats from human MUC1, including six glycosylated sites modified by Ser- or Thr-O- Tn, and is incorporated into the liposomal drug product via two C-terminal lipid serines. The ONT-10 drug product is formulated with the novel, fully synthetic lipid A adjuvant, penta erythritol lipid A (PET Lipid A). PET Lipid A displays a similar spatial distribution of lipid chains as natural Lipid A, but is composed of pure 6-acyl moieties, resulting in enhanced potency as an activator of Toll-like Receptor 2 and 4 (TLR2, TLR4). In preclinical studies, immunization of mice with ONT-10 induces a prominent T cell and antibody response to MUC1 and results in a substantial growth inhibition of MUC1 expressing tumors. T cell recall assays show a Th1 cytokine pattern with strong IFNγ production in spleen derived CD4 and CD8 cells in response to Tn-MUC1. At doses as low as 5μg/mouse ONT-10 results in a high titer anti-MUC1 antibody response composed principally of IgG2b and IgG3 that show preferential binding to Tn-MUC1 and selectively target tumor cells that express human MUC1. In a preventative B16-MUC1 tumor model, vaccination with 5μg ONT-10 potently suppresses tumor growth, resulting in 99% mean tumor growth inhibition relative to controls with 9/12 animals tumor free four weeks after tumor cell implantation. Similarly, in a MC38-MUC1 tumor model 5μg ONT-10 results in an 90% reduction in tumor growth relative to controls. Based on these preclinical data, we propose that the combination of the glycopeptide antigen structure and improved Lipid A adjuvant in ONT-10 offer advantages relative to previous MUC1 targeted vaccines by potently activating both humoral and cellular immunity against hypoglycosylated MUC1 and that these features may provide additional therapeutic benefit to patients with MUC1 expressing cancers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 762. doi:10.1158/1538-7445.AM2011-762