Abstract Beach erosion has direct consequences for Hawaii's tourist-based economy, which depends on the attraction of beautiful sandy beaches. Within the last century, however, beaches on Oahu and Maui have been narrowed or completely lost, threatening tourism and construction development. In order for the counties and state of Hawaii to implement coastal regulations to prevent infrastructure damage, it is necessary to find a statistically valid methodology that accurately delineates annual erosion hazard rates specific to Hawaii. We compare the following erosion rate methods: end point rate (EPR), average of rates (AOR), minimum description length (MDL), jackknifing (JK), ordinary least squares (OLS), reweighted least squares (RLS), weighted least squares (WLS), reweighted weighted least squares (RWLS), least absolute deviation (LAD), and weighted least absolute deviation (WLAD). To evaluate these statistical methods, this study determines the predictive accuracy of various calculated erosion rates, including the effects of a priori knowledge of storms, using (1) temporally truncated data to forecast and hindcast known shorelines and (2) synthetic beach time series that contain noise. This study also introduces binning of adjacent transects to identify segments of a beach that have erosion rates that are indistinguishable. If major uncertainties of the shoreline methodology and storm shorelines are known, WLS, RWLS, and WLAD better reflect the data; if storm shorelines are not known, RWLS and WLAD are preferred. If both uncertainties and storm shorelines are not known, RLS and LAD are preferred; if storm shorelines are known, OLS, RLS, JK, and LAD are recommended. MDL and AOR produce the most variable results. Hindcasting results show that early twentieth century topographic surveys are valuable in change rate analyses. Binning adjacent transects improves the signal-to-noise ratio by increasing the number of data points.


Case name: Doe v. The Trustees of Columbia University in the City of New York, et al., No. 21‐cv‐5839 (S.D. N.Y. 06/27/23).


Abstract The present work investigates the effects of social constraints on word order variation in particle placement in Ontario English, Canada. While previous research has documented numerous linguistic factors conditioning the choice of variant, social correlates have so far remained unexplored. To address this gap, we analyze 6,047 variable phrasal verbs from the vernacular speech of six communities in Ontario. These data were coded for length of the direct object, verb semantics, community, and the individual's education, gender, age, and occupation. Our analyses confirm previous findings that variation in particle placement is predominantly determined by direct object length. However, we also expose significant social and geographic factors, and importantly an effect of age, with younger speakers using the joined variant more than older speakers. Further analysis confirms that the latter effect is consistent across communities, indicating a change in progress, possibly due to ongoing grammaticalization of particles in the verb phrase.


COVID-19 represents high morbidity and mortality, its complications and lethality have increased due to bacterial superinfections. We aimed to determine the prevalence of bacterial superinfection in adults with COVID-19, hospitalized in two clinics in Medellín-Colombia during 2020, and its distribution according to sociodemographic and clinical conditions. A cross sectional study was made with 399 patients diagnosed with COVID-19 by RT-PCR. We determined the prevalence of bacterial superinfection and its factors associated with crude and adjusted prevalence ratios by a generalized linear model. The prevalence of superinfection was 49.6%, with 16 agents identified, the most frequent were Klebsiella (pneumoniae and oxytoca) and Staphylococcus aureus. In the multivariate adjustment, the variables with the strongest association with bacterial superinfection were lung disease, encephalopathy, mechanical ventilation, hospital stay, and steroid treatment. A high prevalence of bacterial superinfections, a high number of agents, and multiple associated factors were found. Among these stood out comorbidities, complications, days of hospitalization, mechanical ventilation, and steroid treatment. These results are vital to identifying priority clinical groups, improving the care of simultaneous infections with COVID-19 in people with the risk factors exposed in the population studied, and identifying bacteria of public health interest.


THE application of electro-encephalography to organic brain lesions has mainly been limited to the study of cases with involvement of the convexity of the hemispheres. In these an expanding lesion is usually associated with potential changes at a frequency well below the normal range-i to 3 c/s. It is generally accepted that discharges at this frequency are pathological when their amplitude approaches that of the normal rhythms (2O0,V). When localized by multi-channel recording, even lower potentials indicate cortical abnormality. These low frequency or " delta" rhythms (Walter, 1936, 1937, 1938) are not specifically diagnostic of new growth for they are also seen in traumatic and degenerative conditions, and in idiopathic epilepsy. One of the main difficulties in interpreting abnormal e.e.g. records is that the waveform is rarely simple or repetitive, as in the electro-cardiogram. Many observers have remarked that in cases of new growth, the waveform of the slow potential changes is particularly irregular and complex, whereas in cases of idiophathic epilepsy the discharge tends to be more stereotyped and rhythmic. An irregular and complex waveform is hard for the unaided eye to interpret, and it is also likely to contain many components. The e.e.g. 'is simply a graph of voltage difference against time. The interpretation of such a graph depends upon the capacity of the eye and brain to analyse a sinuous line in a conventional co-ordinate system. Most people understand readily the meaning of a simple curve, and a little practice gives facility in appreciating a simple periodic one, such as a sine curve. When, however, a periodic curve contains several components, appreciation is more difficult and when the periodicity is irregular and the components variable, the efficiency of the direct visual analysis falls off and fatigue quickly sets in. NQw in the case of t'he e.e.g. a simple periodic curve is an extreme rarity, for only occasionally are two con-


Many surface-like objects around us such as leaves, garments, or boat sails, may easily bend but hardly stretch. One is thus faced with the need for numerical models able to handle inextensibility constraints properly. In the present work we restrict ourselves to the modeling of elastic developable surfaces, i.e., surfaces which always remain isometric to a planar configuration. Our surfaces of interest may however take a non-planar rest configuration, hence we shall model them as developable thin elastic shells. Our goal is to design a both robust and efficient discrete model for simulating the motion of such objects. This work presents a first step towards this direction, by introducing a perfectly inextensible patch for a developable thin elastic shell.


The discovery of two-dimensional monolayer CrI3 provides a promising possibility for developing spintronic devices. However, the low Curie temperature is an obstacle for practical applications. Here, based on the consideration of the superexchange interaction of ferromagnetic coupling, we investigate the effect of introducing I-vacancies and interstitial H-atoms on the Curie temperature of monolayer CrI3 by using first-principles calculations and Monte Carlo simulations. Our theoretical conclusions show that the Curie temperature of Cr8I23 (CrI2.875), Cr8I22 (CrI2.75) and Cr8I24H (CrI3H0.125) significantly increases to 97.0, 82.5 and 112.4 K, respectively. Moreover, the magnetic moment of the Cr atom increases from 3.10 to 3.45 and 3.46μB in monolayers Cr8I23 and Cr8I22, respectively. We provide more alternative approaches to effectively enhance the Curie temperature of monolayer CrI3, which will help both theoretical and experimental researchers to directly predict the change in Curie temperature of CrI3 and its analogs through structural information.


We fabricated a fully integrated WiMAX transceiver in a 90-nm CMOS that can reduce balun and matching network components on an RF module board. Output linearity of up to 12 dBm and a wide variable gain range of 60 dB were achieved using a single-ended signal interface for the PA driver of the transmitter. A combination of a class AB amplifier and a class C amplifier is used for the driver to widen the linearity. Placing the single-ended to differential converter between the LNA and down-conversion mixer gives the receiver wide linearity without the use of a balun. The use of the improved matching network in the LNA results in an S11 of better than -20 dB at between 2.5 and 2.7 GHz. Measurement of the characteristics of a transceiver fabricated on an IC chip shows that it satisfies the WiMAX standard.


Hemoglobin (Hb) adducts, formed by the neurotoxic agent acrylamide (AA) and its genotoxic metabolite glycidamide (GA), were measured in the rat by means of a method for simultaneous determination of the adducts formed to cysteine. A novel, nonlinear dosimetric model was developed to describe Hb adduct formation. This model incorporates the saturable kinetics of the metabolic conversion in vivo of AA to GA. The pharmacokinetic parameters Vmax and Km and the first-order rates of elimination, k1 and k2, for AA and GA from all processes except conversion of AA to GA, were estimated directly from Hb adduct data to 19 M hr-1, 66 microM, 0.21 hr-1, and 0.48 hr-1, respectively. At low concentrations, approximately 60% of AA was metabolized to GA. The nonlinear dosimetric model for adduct formation has potential general applicability in high-to-low-dose extrapolation of genotoxic effects.


This paper proposes a fundamental answer to a frequently asked question in multimedia computing and machine learning: Do artifacts from perceptual compression contribute to error in the machine learning process and if so, how much? Our approach to the problem is a reinterpretation of the Helmholtz Free Energy formula from physics to explain the relationship between content and noise when using sensors (such as cameras or microphones) to capture multimedia data. The reinterpretation allows a bit-measurement of the noise contained in images, audio, and video by combining a classifier with perceptual compression, such as JPEG or MP3. Our experiments on CIFAR-10 as well as Fraunhofer's IDMT-SMT-Audio-Effects dataset indicate that, at the right quality level, perceptual compression is actually not harmful but contributes to a significant reduction of complexity of the machine learning process. That is, our noise quantification method can be used to speed up the training of deep learning classifiers significantly while maintaining, or sometimes even improving, overall classification accuracy. Moreover, our results provide insights into the reasons for the success of deep learning.


The crystallization of amorphous Ge2Sb2Te5 (GST) doped with nitrogen is studied with pulsed laser heating. The crystallization time of sputter-deposited films is increased by doping by as much as 100× for nitrogen concentrations of the order of 12 at. % in as-deposited amorphous films. Suppression of the formation of critical crystal nuclei is found to be responsible. The crystallization of melt-quenched amorphous material is also slowed by doping but less dramatically.


Abstract Over the past 20 years, hydroxyurea (HU) has emerged as an important therapeutic agent to augment Hb F and thus total hemoglobin (Hb) in Hb E [β26(B8)Glu→Lys; HBB: c.79G>A]-β-thalassemia (Hb E-β-thal), albeit used in varying doses with little consensus on its optimal dose. We report the interim analysis findings of a broader study to assess the impact of Comprehensive Thalassemia Care, of which the present report was a part. Sixty-one Hb E-β-thal patients who were transfusion independent or requiring occasional transfusions [β-thal intermedia (β-TI)] were randomized to one of two groups; A (n = 32) and B (n = 29) to receive 10 and 20 mg/kg/day HU, respectively. The primary objective of the study was to assess the differences in responses to different doses of HU. Secondary end points were to see the tolerability and safety of HU in different doses. Good response (GR) was defined as a rise of Hb by >1.0 g/dL; intermediate response (IR) as a rise in Hb by 0.6–1.0 g/dL anytime during the study period. No response (NR): rise in Hb by <0.5 g/dL in 12 weeks or drop in Hb level from the previous value. Over a follow-up period of 24 weeks, we had 18 (56.2%) GRs, nine (28.2%) IRs and five (15.6%) NRs, while the number of GRs, IRs and NRs in group B were five (17.2%) 12 (41.4%) and 12 (41.4%), respectively. Adverse effects were more common in group B, making this dose (20 mg/kg/day) of HU more myelo-suppressive than Hb F inducing.


ABSTRACT Asthma increased dramatically in the last decades of the 20th century and is representative of chronic diseases that have been linked to altered microbial exposure and immune responses. Here we evaluate the effects of environmental exposures typically associated with asthma protection or risk on the microbial community structure of household dust (dogs, cats, and day care). PCR-denaturing gradient gel analysis (PCR-DGGE) demonstrated that the bacterial community structure in house dust is significantly impacted by the presence of dogs or cats in the home (P = 0.0190 and 0.0029, respectively) and by whether or not children attend day care (P = 0.0037). In addition, significant differences in the dust bacterial community were associated with asthma outcomes in young children, including wheezing (P = 0.0103) and specific IgE (P = 0.0184). Our findings suggest that specific bacterial populations within the community are associated with either risk or protection from asthma.


Relevance and methods. The studies were carried out in 2017–2019. on podzolized chernozem in the forest-steppe zone of the European part of Russia on the territory of the Republic of Mordovia. Weather conditions during the years of research varied from humid to extremely arid. Intensive methods of tillage helped to reduce soil moisture before sowing peas.Results. Compared to direct sowing, humidity decreased by 11–39% in the upper soil layer, by 5–12% in the arable horizon. Productive moisture reserves were lower for plowing and discing than for direct sowing: 21–33% before sowing, and 27–34% in the budding phase. The maximum differences in the reserves of productive moisture between the methods of tillage were noted in 2018 during the phase of pea budding. In the cases with plowing and discing, the moisture content decreased in the horizon of 0–30 cm to critical values of 0–10 mm/ha. Significant differences in pea productivity between options with tillage were revealed only in 2019. The maximum yield was observed on plowing – 5.54 t/ha, the minimum on the option with direct sowing — 5.54 t/ha. Under drought conditions, maximum yields were observed in the variant with direct sowing of pea seeds.


An automatic multi-parameter joint monitoring device is designed for buried pipelines on slopes in frozen soil regions considering the difficulties and shortcomings of traditional techniques for the monitoring of geological disasters on slopes in frozen soil regions, which features high measuring accuracy and stable reliability, and introduces the wireless network technology to set up a remote monitoring system, including the hardware and software design that covers single chip, ZigBee and satellite communications. The device measures such parameters as temperature field, soil water content, surface deformation, deep displacement and pipe strain in real time through monitoring sensors distributed at the terminal, gathers monitoring results to the coordinator nodes through wireless communication, and finally transmits them to the remote monitoring center through satellite communication module. It is proved through field tests that this monitoring system is featured by low cost, high reliability and easy-to-network, and can be used for the remote and automatic monitoring of safe operation of buried pipelines on slopes in frozen soil regions.


Objective To evaluate the successful fusion rate in postmenopausal women with single-level anterior cervical discectomy and successful fusion (ACDF) and identify the significant factors related to bone successful fusion in pre- and postmenopausal women. Methods From July 2004 to December 2010, 108 consecutive patients who underwent single-level ACDF were prospectively selected as candidates. Among these, the charts and radiological data of 39 women were reviewed retrospectively. These 39 women were divided into two groups : a premenopausal group (n=11) and a postmenopausal group (n=28). To evaluate the significant factors affecting the successful fusion rate, the following were analyzed : the presence of successful fusion, successful fusion type, age, operated level, bone mineral density, graft materials, stand-alone cage or plating with autologous iliac bone, subsidence, adjacent segment degeneration, smoking, diabetes mellitus, and renal disease. Results The successful fusion rates of the pre- and postmenopausal groups were 90.9% and 89.2%, respectively. There was no significant difference in the successful fusion rate or successful fusion type between the two groups. In the postmenopausal group, three patients (10.8%) had successful fusion failure. In the postmenopausal group, age and subsidence significantly affected the successful fusion rate (p=0.016 and 0.011, respectively), and the incidence of subsidence in patients with a cage was higher than that in patients with a plate (p=0.030). Conclusion Menopausal status did not significantly affect bone successful fusion in patients with single-level ACDF. However, in older women with single-level ACDF, the combination of use of a cage and subsidence may unfavorably affect successful fusion.


"What a wonderful, beautiful, marvelous country! Oh--h--h!!",says Pinocchio at the end of the Chapter XXX of "The Adventures", after Lamp-Wick explained him the amazing features of the "real country--the best in the world--a wonderful place!": the Land of Toys, also named "blessed place" and portrayed as a sort of heaven on heart for lazy boys. In reality, the approaching road to the Land of Toys, before as a mental process, - a persuasion of himself – and then as real journey, it's like a fall to hell. The master of ceremonies of this fall to hell is just the fellow Lamp-Wick,in fact in the original version of the book Lamp-Wick is "Lucignolo", a name reminiscent of Lucifer, the famous fallen angel. Lamp-Wick and Pinocchio work up to the Land of Toy in a wagon conducted by a spineless, shifty driver: "a little, fat man, muchwiderthan he was long, round and shinyas a ball of butter, with a face beaminglike an apple, a little mouth that always smiled, and a voice small and wheedling like that of a catbegging for food". This "little, fat man" is a sort of Charon, and the wagon: "wasdrawn by twelve pair of donkeys, all of the same size, but all of different color. Some weregray, otherswhite, and still others a mixture of brown and black. Here and there were a few with large yellow and blue stripes.". These queerd on keys, recurring frequently in the fairytale and they are full of double meaning: in half way point between the numinoso Christ's whitehorse and the demonic Cambridge Bestiary. Pinocchio and Lamp-Wick glorify the life in the Land of Toys: they feel free and happy like in heaven, but the hard truth is very different: this land looks like the Hell, everywhere is noise, disorder, insecurity. During the development of the story, it's possibile to detect different elements of the Pinocchio's rise and fall between Heaven and Hell. For example the double nature of the Fairy: during the tale she can be the ghost of the little girl (de facto an angel) or she can be a goat (a devil's mark). Talking about rise and fall, the end of the story is paradigmatic: Pinocchio will get a real boy. Acquiring the human nature, he will be able to find the Heaven on earth, after a long series of ups and downs, starting with a "badhell night".


BACKGROUNDS
The cancerogenic effect of ionizing radiation was documented just several years after it started to be used as a treatment option. Ionizing radiation produces a small but detectable risk of carcinoma as well as bone and soft tissue sarcomas. Over the past 20 years angiosarcomas arising from the area of the irradiated breast have been reported with increasing frequency as the number of women undergoing the breast conserving surgery with consecutive radiotherapy has increased also. Angiosarcomas can originate from either lymphatic or capillary endothelium, namely lymphangiosarcomas and haemangiosarcomas. The most of haemangiosarcomas arising from the breast skin developed in the irradiated area after breast conserving procedure--secondary angiosarcomas. Lymphangiosarcoma is typically associated with longstanding extremity lymphedema--Stewart-Treves syndrome.

CASES
We report three cases of angiosarcomas which occured in this region after breast conserving treatment and we also review the literature.

CONCLUSION
Paradoxically, the decrease in the use of radiotherapy to the post-mastectomy chest wall and the axillary area is expected to reduce the incidence of angiosarcomas, while the increase in the use of breast conserving procedure plus radiotherapy could lead to increased incidence of angiosarcomas in the residual breast tissue. Special attention should be paid to skin leasions and changes occuring after breast conserving treatment and especially to the ones with the skinthickening. The early detection and diagnosis has the crucial prognostic value.


For 7 months, serum samples reflecting high, normal, and low physiologic values were distributed to five laboratories for sodium, potassium, and calcium analyses. Following recalibration of instruments and required repairs, quality control programs were initiated and additional serum samples were analyzed. The results were collected and statistics calculated to determine improvement, if any, in accuracy and precision. Improvement was demonstrated in some cases.


Nowadays, the advertisement is one of the key activities of sale. An advertisement is not always true and sometimes it could be even misleading or false. This chapter is focused on the exemplary verification of the truth of the concrete advertisement. The verification has been provided based on the data coming from the research being provided among 300 young customers from the Czech Republic. The data have been processed statistically, and based on the hypothesis testing using one-way analysis of variance (ANOVA), the data are evaluated whether the advertisement is true or misleading. Research findings provide testimony of unfair practice of advertisement.


In this paper, I extend Ossa (2011) to study the impact of the Most-Favored-Nation principle (MFN) of GATT/WTO on the characterization of Pareto-improving bilateral trade agreements. The paper offers four main model predictions. First, I characterize bilateral trade agreements with third-country tariff adjustments that improve the welfare of negotiating countries while preserving the welfare of the outside country unchanged. Second, MFN guarantees that a bilateral trade agreement always improves the welfare of outside country and potentially causes a free- rider problem. Third, MFN can be too restrictive and prevent possible Pareto-improving trade agreements if initial tariffs are generally low. Lastly, this paper suggests a reason of why free trade agreements (FTAs) are more desirable than bilateral trade agreements under MFN, when current tariffs are sufficiently low. I quantify the firm-delocation effects and welfare changes in three counterfactual situations: (i) a bilateral trade agreement without third-country tariff adjustments, (ii) a bilateral trade agreement under MFN, and (iii) moving to a global free-trade economy. The quantitative results support the model predictions.


This interventional study was carried out in ENT Department of Combined Military Hospital Rawalpindi, a tertiary care hospital, from January 1993 to December 2000, to determine the sex incidence, laterality and type of congenital meatal atresia, and possible etiological factors; and secondly to determine the results of surgery in terms of hearing gain and incidence of complications while comparing trans-mastoid approach with the anterior approach. 42 patients of both sexes with congenital meatal atresia, up to the age of 25 years were selected by non-probability sampling. A detailed history and a detailed physical examination showed consanguinity as the biggest possible etiological factor (40.4%), male to female ratio of 2.5:1, unilateral to bilateral ratio of 1.6:1, type II atresia in 50%, type I atresia in 35.7% and type III atresia in 14.2%. X-ray mastoids and CT scan showed favourable anatomy in 36 patients who were selected for surgery. Canalplasty with tympanoplasty was carried out in them, via trans-mastoid approach in ten and direct anterior approach in 26 patients. Pre and post-operative Audiological Brainstem Response and Pure Tone Audiometry (over 4 years of age) showed successful surgery in 19 (52.7%) patients having post-operative hearing thresholds of up to 25-30 dB. Success rate was 61.3% with the anterior approach as compared to 30% with the trans-mastoid approach. Post-operative complications as re-stenosis (16.6%), otorrhoea (11.1%) and facial paralysis (2.7%) occurred in 11 (30.55%) patients. Complication rate was 50% with trans-mastoid approach and 27% with anterior approach. Consanguinity must be studied in greater detail as an important possible etiological factor.


Both analytic and numerical means are used to demonstrate amplitude and phase behavior of reflections from three‐dimensionally curved interfaces. In particular, the high‐frequency geometrical optics approximation for the backward scattered wave field demonstrates that the phase of a reflection from a syncline is determined by the (in general, different) positions of focal regions for the two principal curves at the specular reflection point. Thus the amplitudes and phases of events observed on seismic sections are influenced as much by the shape of the reflector "out‐of‐the‐plane" as by the shape in the plane of the section. Results of the numerical examples suggest possible pitfalls in traditional interpretation of two‐dimensional seismic data.


We report an Inelastic Neutron Scattering (INS) study of the fully deuterated molecular compound K6[V15IVAs6O42] · 9D2O (V15). Due to geometrical frustration, the essential physics at low temperatures of the V15 cluster containing 15 coupled V4+ (S = 1/2) is determined by three weakly coupled spin-(1/2) on a triangle. The INS spectra at low energy allow us to directly determine the effective exchange coupling J0 = 0.211(2) meV within the triangle and the gap 2Δ = 0.035(2) meV between the two spin-(1/2) doublets of the ground state. Results are discussed in terms of deviations from trigonal symmetry and Dzyaloshinskii-Moriya (DM) interactions.


draws from interviews and participant observation to tell us, often in people's own words, about the fears, hopes, and values of the Canarsians. The story he tells is, he thinks, a cautionary tale for the New Deal Democratic party. In Canarsie and elsewhere, a &dquo;new breed of political entrepreneurs ... more confortable in the familiar niches of the neighborhood has emerged on the wave of anxiety and outrage&dquo; about changing racial composition, crime and deteriorating schools, and the perceived disproportionate gains of blacks. The &dquo;geopolitics of local community&dquo; among white ethnics represents a formidable challenge for liberals and others who would revitalize broad cross-racial and cross-class coalitions in the future. The actual


Women's political engagements often look different from those of men, and they are also undertheorized and understudied. The author examines how participation in family-focused community organizing shapes women's lives, self-perceptions, and relationships. Using 15 months of participant observations of organizing activities and 40 interviews with parent organizers the author calls motherleaders, the author demonstrates how family-focused community organizing shapes participants' lives in ways that help them leave "shells" of fear, vulnerability, and despair within their often marginalized lives as women of color, recent immigrants, and low-income mothers. The personal narratives of motherleaders demonstrate how their collective action transcends publicly stated formal organizational goals and powerfully affects them in life-altering ways. It is important that scholars seriously consider the intersecting identities of collective action participants, the meanings participants construct of and through "politics," and the power of collective action to transform the lives of marginalized groups.


The sural nerve is at risk of iatrogenic injury even during minimally invasive operative procedures to repair the calcaneal (Achilles) tendon. Through 107 cadaveric leg dissections, the data derived from the present study was used to develop a regression equation that will enable surgeons to estimate the intersection point at which the sural nerve crosses the lateral border of the Achilles tendon, an important surgical landmark. In most cases, the sural nerve crossed the lateral border of the Achilles tendon 8 to 10 cm proximal to the superior border of the calcaneal tuberosity. By simply measuring the leg length of the patient (from the base of the heel to the flexor crease of the popliteal fossa), surgeons can approximate the location of this intersection point with an interval length of 0.68 to 1.80 cm, with 90% confidence, or 0.82 to 2.15 cm, with 95% confidence. For example, for a patient with a lower leg length of 47.0 cm, the mean measurement in the present study, a surgeon can be 90% confident that the sural nerve will cross the lateral border of the Achilles tendon 8.28 to 8.96 cm (interval width of 0.68 cm) proximal to the calcaneal tuberosity. Currently, ultrasound and clinical techniques have been implemented to approximate the location of the sural nerve. The results of the present study offer surgeons another method, that is less intensive, to locate reliably and subsequently avoid damage to the sural nerve during calcaneal (Achilles) tendon repair and other procedures of the posterolateral leg and ankle.


We have determined the changes in fecundity, mortality, and growth of the ploimate rotifer, Asplanchna girodi, in response to variations in food density. Rotifers were raised from birth on either fixed allotments of Paramecium tetraurelia or on allotments that varied temporally. Fecun- dity, growth rates, and size of the rotifer at the time of birth of the first offspring varied directly with food level. Longevity and age at the birth of the first young varied inversely with food level. The size of offspring remained constant regardless of parental food intake. Individuals switched from low to high food rations produced more offspring than those given a high ration from birth. The per capita death rate was insensitive to food level, but the birth rate varied directly with food level. Young individuals were better able to resist starvation than adults. These responses of A. girodi to varying resource densities are interpreted as being adaptive in environments with temporally varying food resources. When food levels are high, many young are produced and act to buffer the population against a decline in numbers when the food levels are reduced. The restoration of higher food levels causes the starved individuals to respond with high fecundities, which act to restore population densities to previous levels. In all resource environments, individual fecundity is adjusted to produce young with high chances of survival and reproduction.


We propose a novel general-purpose network traffic monitoring application programming interface (MAPI) for network monitoring applications. Our work builds on a generalized network flow model that we argue is flexible enough to capture emerging application needs, and expressive enough to allow the system to exploit specialized monitoring hardware, where available. We describe an implementation of MAPI using the DAG 4.2 Gigabit Ethernet monitoring card and a commodity Gigabit Ethernet adapter, we present a set of experiments measuring overheads, and we demonstrate potential applications. Our experimental results suggest that MAPI has more expressive power than competing approaches, while at the same time is able to achieve significant performance improvements.


In the article, the author points out the need for the development of a speech personality in educational institutions as a prerequisite for the development of harmonization of the personality, its successful socialization in society. Modern documents and regulations indicate exactly this. A number of statistical data is also provided on the insufficient level of development of the adolescents' speech competence as a component of the communicative competence, which in turn creates unfavorable conditions for the adolescent's socialization and his/her adaptation in society.
The article also examines the features of the development of the lexical and grammatical component of the speech of younger adolescents in the conditions of primary school as a necessary component of the speech competence formation. The necessity of developing a special speech environment in a school is substantiated, the participants of which should be both objects of educational influence (adolescents) and teachers, specialists working in the educational space of a basic school. According to the results of the experiment, the peculiarities of the development of the lexical and grammatical aspects of speech of adolescents, studying in the inclusive environment of the primary, school are determined. The analysis of the influence of the level of formation of the lexical and grammatical aspect of speech on the formation of negative character traits in adolescents is carried out. The necessity of correction of speech disorders in adolescents has been proved in order to prevent difficulties in the educational process and socialization of the personality. These facts, in turn, prove the need for active speech therapy support for younger adolescents in a basic school environment


Measurement of tear volume by phenol red thread tear test (PRT), Schirmer's tear test (STT-1) and Schirmer's tear test with topical anesthesia (STT-2), and vital staining with a combination of fluorescein and rose Bengal of the cornea were performed in dogs with normal eyes and those with epiphora. The breeds included the Shih-Tzu (n = 26), and five other breeds (n = 50). The PRT, STT-1 and STT-2 results from the five breeds of normal dogs were 26.9 +/- 3.0 mm, 17.4 +/- 4.3 mm, and 8.8 +/- 3.2 mm, respectively. The PRT, STT-1, and STT-2 results for the Shih-Tzu eyes were (mean +/- standard deviation): 28.2 +/- 4.3 mm, 19.5 +/- 4.1 mm, and 9.2 +/- 4.5 mm, respectively. In the five breeds, corneal epitheliopathy, as evidenced by the retention of topical fluorescein and rose Bengal, occurred in 97% of dogs with epiphora and in 55% of the dogs without epiphora. Also in the dogs with corneal epitheliopathy the STT-2-value was low (4.0 +/- 2.8 mm) compared with those eyes without corneal epitheliopathy (8.8 +/- 3.1 mm). In the Shih-Tzu breed the STT-2 results were not significantly different between those dogs with corneal epitheliopathy and those with normal corneas. In the non-Shih-Tzu breeds the decrease in basic tear secretion, as measured by the STT-2, is associated with the corneal epitheliopathy.


and the problems were not shown to have clinical importance. The investigators rehydrated the children using an intragastric drip. We successfully treated a large number ofchildren from 2 months of age upwards with the solution recommended by the WHO. We normally give the solution as a drink, when the children's thirst controls the amount they take in, and we have found no problems with salt overload. Only in the relatively few children given the solution by intragastric drip for specific reasons (most commonly stomatitis, prostration, or excessive vomiting), have we sometimes encountered periobital oedema among the children a few months old, but this did not appear to influence recovery. We agree with the generally accepted practice that the oral solution should normally be given as a drink. This is not only pleasanter for the child, but it is the only method suitable for mass use in developing countries, where shortages of trained staff and equipment will generally be much greater than in the conditions of the study in the Calcutta Medical College Hospitals. This method also allows for the close collaboration of the mother in her child's treatment with its potential for health education; and evidently it may be safer. The common problem in poor conditions with inexperienced mothers and lack of staff is not overhydration but that the child will be given insufficient fluid. In these conditions the solution of higher sodium content is more practical since the volumes needed are less. Additional free water is neither necessary nor recommended. In Mozambique the national policy (Melamed and Segall, 1978) is to use the solution recommended by the WHO.


A 44-year-old man diagnosed with HIV in 1992 has become 3TC-resistant, has had adverse effects to ddI, and most likely will have the same adverse effects to d4T and ddC. The Ritonavir, Saquinavir, and Nevirapine combination he was switched to did not reduce his viral load, however, the patient was clinically stable without wasting or opportunistic infections, and his CD4 count was 220 cells/mm3. Based on past responses to medication and to the available NNRTIs, it is believed that the patient is currently cross-resistant to all first-generation protease inhibitors. It was suggested that the patient, now categorized as having virologic failure but clinical/immunologic success, is unlikely to achieve durable suppression, even with the new drugs becoming available. Mega-HAART therapy, which uses up to eight drugs, may work temporarily but appears to be intolerable in the long term for most patients. It is not known how long the patient's clinical/immunologic stability will last, but it is unlikely to continue indefinitely in the presence of high viral replication. In the case of worsening conditions, it is suggested that a phenotypic analysis be done to guide salvage therapy. In the absence of a phenotypic analysis, it is suggested to try a combination of ddI plus d4T plus Hydroxyurea plus Nelfinavir plus efavirenz.


We present a method to evaluate the free energies of ligand binding utilizing a Monte Carlo estimation of the configuration integrals concomitant with uncertainty quantification. Ensembles for integration are built through systematically perturbing an initial ligand conformation in a rigid binding pocket, which is optimized separately prior to incorporation of the ligand. We call the procedure producing the ensembles "blurring", and it is carried out using an in-house developed code. The Boltzmann factor contribution of each pose to the configuration integral is computed and from there the free energy is obtained. Potential function uncertainties are estimated using a fragment-based error propagation method. This method has been applied to a set of small aromatic ligands complexed with T4 Lysozyme L99A mutant. Microstate energies have been determined with the force fields ff99SB and ff94, and the semiempirical method PM6DH2 in conjunction with continuum solvation models including Generalized Born (GB), the Conductor-like Screening Model (COSMO), and SMD. Of the methods studied, PM6DH2-based scoring gave binding free energy estimates, which yielded a good correlation to the experimental binding affinities (R2 = 0.7). All methods overestimated the calculated binding affinities. We trace this to insufficient sampling, the single static protein structure, and inaccuracies in the solvent models we have used in this study.


This archive manuscript is an English translation of a 25-page excerpt from Marx's Manuscript of 1867–68, which was published for the first time in German in 2012 in the MEGA, Volume II/4.3. This excerpt is Marx's first and only attempt to incorporate unequal turnover times across industries into his theory of the equalisation of the profit rate and prices of production. The excerpt considers three cases: unequal turnover times across industries, unequal compositions of capital across industries, and both of these inequalities together. It also emphasises two concepts of the rate of profit: rate of profit on capital advanced and rate of profit on the cost price (capital consumed).


The authors propose a novel and efficient method for single image dehazing. To accelerate the transmission estimation process, a block-to-pixel interpolation method is used for fine dark channel computation, in which the block-level dark channel is first computed, and then the fine pixel-level dark channel is obtained by a weighted voting of the block-level dark channel to preserve edges and smooth out texture noise. This technique can be used for a direct transmission map generation without a computationally expensive refinement step. Since the dark channel prior (DCP) is not valid in bright (sky) regions, they propose an adaptive DCP modelled by a Gaussian curve that produces a more natural recovered image of the sky and other bright regions. In addition, a scaling method for transmission map computation is proposed to further accelerate the dehazing method. Through experiments, they show that the proposed adaptive block-to-pixel technique is about 30 times faster and produces improved recovered images than the well-known state-of-the-art DCP approach.


The water mass transformation (WMT) framework describes how water of one class, such as a discrete interval of density, is converted into another class via air-sea fluxes or interior mixing processes. This paper investigates how this process is modified at the surface when mesoscale ocean eddies are present, using a state-of-the-art high-resolution climate model with reasonable fidelity in the Southern Ocean. The method employed is to coarse-grain the high-resolution model fields to remove eddy signatures, and compare the results with those from the full model fields. This method shows that eddies reduced the WMT by 2 to 4 Sv (10% to 20%) over a wide range of densities, from typical values of 20Sv in the smoothed case. The corresponding water mass formation was reduced by 40% at one particular density increment, namely between 1026.4 kgm−3 and 1026.5 kgm−3, which corresponds to the lighter end of the range of Indian Ocean modewater in the model. The effect of eddies on surface WMT is decomposed into three terms: direct modulation of the density outcrops, then indirectly, by modifying the air-sea density flux, and the combined effect of the two, akin to a covariance. It is found that the first and third terms dominate, i.e. smoothing the outcrops alone has a significant effect, as does the combination of smoothing both outcrops and density flux distributions, but smoothing density flux fields alone has little effect. Results from the coarse-graining method are compared to an alternative approach of temporally averaging the data. Implications for climate model resolution are also discussed.


The right to religious freedom is generally believed to be the solution to religious intolerance and discrimination and to ensure world peace amongst world citizens. On an international level, the United Nations, through the appointment of a special rapporteur for freedom of religion and belief, has introduced a tool to monitor violations of this right. This tool is known as 'the framework of communications' and is focused mainly on the relationship between governments and religions. Unfortunately, religion is not excluded from the violation of human rights within its own ranks. This article pointed out that however pure the intention of freedom of religion, no real measures are in place to address violations of human rights in minority religions. Therefore, a tool is needed to investigate and address alleged violations within minority religions.


Pyridoxal 5′-phosphate (PLP), the active form of vitamin B6, works as cofactor in numerous enzymatic reactions and it behaves as antioxidant molecule. PLP deficiency has been associated to many human pathologies including cancer and diabetes and the mechanism behind this connection is now becoming clearer. Inadequate intake of this vitamin increases the risk of many cancers; furthermore, PLP deprivation impairs insulin secretion in rats, whereas PLP supplementation prevents diabetic complications and improves gestational diabetes. Growing evidence shows that diabetes and cancer are correlated not only because they share same risk factors but also because diabetic patients have a higher risk of developing tumors, although the underlying mechanisms remain elusive. In this review, we will explore data obtained in Drosophila revealing the existence of a connection between vitamin B6, DNA damage and diabetes, as flies in the past decade turned out to be a promising model also for metabolic diseases including diabetes. We will focus on recent studies that revealed a specific role for PLP in maintaining chromosome integrity and glucose homeostasis, and we will show that these aspects are correlated. In addition, we will discuss recent data identifying PLP as a putative linking factor between diabetes and cancer.


OBJECTIVE
To investigate the expressions of glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) in the liver of mice with hyperhomocysteinemia (HHcy) and explore the mechanism of gluconeogenesis induced by homocysteine.

METHODS
Fifty mice were randomly divided into normal control group (n=25) and HHcy group (n=25) and fed with normal food and food supplemented with 1.5% methionine, respectively. After 3 months of feeding, the fasting blood glucose and insulin levels were determined, and HOMA insulin resistance index (HOMA-IR) was calculated. The expressions of G6Pase and PEPCK in the liver of mice were detected using RT-PCR and Western blotting.

RESULTS
The fasting blood glucose and insulin levels and HOMA-IR were significantly higher in HHcy group than in the control group (P<0.05). RT-PCR and Western blotting showed that the hepatic expressions of G6Pase and PEPCK mRNA and proteins increased significantly in HHcy group compared with those in the control group (P<0.05).

CONCLUSION
Homocysteine promotes gluconeogenesis to enhance glucose output and contribute to the occurrence of insulin resistance.


A new NH4+ adsorbent with high capacity and selectivity, sodium cobalt(ii) hexacyanoferrate(ii) (NaCoHCF, NayCo(ii) [Fe2+(CN)6]x·zH2O), was prepared. The adsorption performance was investigated by varying the mixing ratio of [Fe(CN)6]4− to Co2+ during synthesis, Rmix. The ammonia capacity was found to be proportional to Rmix, indicating that the NH4+ capacity can be increased by increasing the Na+-ion content in NaCoHCF. To conduct a detailed study, we prepared homogeneous nanoparticles by flow synthesis using a micromixer with Rmix = 1.00. Even on the addition of a saline solution (NaCl) with an Na+-ion concentration of 9350 mg L−1, the capacity was maintained: qmax = 4.28 mol kg−1. Using Markham–Benton analysis, the selectivity factor, defined by the ratio of equilibrium constants for NH4+ to that for Na+, was calculated to be α = 96.2, and 4.36 mol kg−1 was found to be the maximum capacity. The high selectivity of NaCoHCF results in good NH4+-adsorption performance, even from seawater. In comparison with other adsorbents under the same conditions and even for a NH4Cl solution, NaCoHCF showed the highest capacity. Moreover, the coexisting Na+ caused no interference with the adsorption of ammonium by NaCoHCF, whereas the other adsorbents adsorbed ammonia only slightly from the saline solution. We also found that the pores for NH4+ adsorption changed their sizes and shapes after adsorption.


This article examines the politics of language in plurinational states. First, I argue that the relationship between language and nationhood is politically constructed through two broad processes: state nation-building and 'peripheral' activism. Second, I present three broad strategies of territorial management to accommodate the normative and practical issues derived from the politicisation of languages: self-rule, shared rule, and symbolic recognition. Third, I illustrate the discussion drawing on the paradigmatic cases of Catalonia and Flanders. Linguistic Diversity in Plurinational States | 2


OBJECTIVE: To determine efficient ways of promoting advance directives among heterogeneous populations of elderly ambulatory patients.DESIGN: One-year quasi-experimental trial.SETTING: Five suburban and urban health centers in one region of a large managed care organization. One additional suburban center served as a control site.PARTICIPANTS: Individuals ages 65 and older (N=2,120) who were continuously enrolled and had a health maintenance visit with their primary care provider during the study year.INTERVENTION: Physician education (oral and written) and physician and patient prompts to discuss advance directives.MAIN RESULTS: Sixty-six (7.8%) of patients at the intervention centers completed new advance directives, versus 9 of 1,277 (<1%) at the comparison center (P<.001). Patients 75 and older were twice as likely (odds ratio [OR], 2.0; 95% confidence limits [CL], 1.2 to 3.3) as those 65 to 74 to file a new advance directive, and the odds were twice as great (OR, 2.6; 95% CL, 1.4 to 4.6) at centers serving communities with median household income over the state median. Gender, recent hospitalization, emergency room visits, and number of chronic conditions were not related to making new directives nor was predominant ethnicity of the center community (African-American versus white). Adjusted for these factors, the intervention resulted in a 20-fold increase (95% CL, 10.4 to 47.8) in the odds of creating a new advance directive. Doctors reported barriers of time and unwillingness to press discussions with patients.CONCLUSIONS: A replicable intervention largely targeting doctors achieved a modest increase in advance directives among elderly ambulatory patients. Future interventions may need to target lower-income patients, "younger" elderly, and more specifically address doctors' attitudes and comfort discussing advance directives.


Vitesse has developed an indium phosphide (InP) heterojunction bipolar transistor (HBT) process and used that process for the fabrication of 40Gbit/s communication circuits. The process is run in the Vitesse 4" wafer fab located in Camarillo, Ca which is dedicated to the production of InP circuits. Transistor performance of 150GHz for ft and fmax are achieved with a conservative mesa isolated NPN structure that leaves room for future advancements through device scaling. Single (SHBT) and double (DHBT) transistor structures have both been fabricated with success. PIN photodetectors have also been built in this process allowing the integration of optical functions. Circuits discussed here have been built in the SHBT process. The process is designed around high yield manufacturable methods which have produced circuits with excellent yield. Circuits have been designed using both distributed and lumped element architectures with success. A building block approach has been used to maximize yield, schedule, and performance success. At this time all key building blocks for the OC -768 physical layer have been demonstrated. A TIA, limiting amp, PIN diode, 4:1 MUX/DEMUX pair, and a driver with 3.5V pp swing have all been demonstrated in the lab and are now being sampled to customers.


This paper treats channel estimation in multiple-input multiple-output (MIMO) orthogonal frequency division multiplexing (OFDM) systems with correlation at the receive antenna array. A two-step channel estimation algorithm is proposed. Firstly, the iterative quadrature maximum likelihood based time delay and spatial signature estimation is presented by utilizing special training signals with a cyclic structure. The receive spatial correlation matrix of the vector valued channel impulse response is formulated as a function of the spatial signature, the time delay, and the pulse shaping filter. The joint spatio-temporal (JST) filtering based minimum mean squared error channel estimator is derived by virtue of the spatial correlation. In addition, the effect of channel estimation errors on the bit error probability performance of the space-time block coded OFDM system over correlated MIMO channels is derived. The Cramer-Rao lower bound on the time delay estimate is provided for a benchmark of the performance comparison. The performance of proposed algorithms is illustrated based on analysis and computer simulations. The JST channel estimator achieves significant gains in the mean squared error compared to the temporal filtering. It also enables remarkable savings in the pilot symbol power level.


Reactions of simple and composite receptive fields (RF) of the 17th and 18th fields of cat's visual cortex to grating with various spatial frequency moving through the field with different velocities were studied. It has been shown that for each RF the velocity range is revealed within which spatial-frequency selectivity of RF exists. The narrow-band tuning for high frequency RF exists in the range of low velocities, and for low frequency ones in the range of higher velocities.


Many engineering problems involve solving large linear systems of equations. Conjugate gradient (CG) is one of the most popular iterative methods for solving such systems. However, CG typically requires a good preconditioner to speed up convergence. One such preconditioner is the sparse approximate inverse (SPAI). In this paper, we explore the computation of an SPAI on quantum annealing machines by solving a series of quadratic unconstrained binary optimization (QUBO) problems. Numerical experiments are conducted using both well-conditioned and poorly-conditioned linear systems arising from a 2D finite difference formulation of the Poisson problem.


With developing congestive heart failure (CHF), activation of the vasopressin V(1a) and angiotensin II type 1 (AT(1)) receptors can occur. In the present study, we examined the direct effects of V(1a) receptor blockade (V(1a) block), selective AT(1) receptor blockade (AT(1) block), and dual V(1a)/AT(1) receptor blockade (dual block) with respect to left ventricular (LV) function and contractility during the progression of CHF. LV and myocyte functions were examined in pigs with pacing CHF (rapid pacing, 240 beats/min, 3 weeks, n = 10), pacing CHF with concomitant V(1a) block (SR49059, 60 mg/kg, n = 8), pacing CHF with concomitant AT(1) block (irbesartan, 30 mg/kg, n = 7), or pacing CHF with dual block (n = 7). LV end-diastolic dimension and peak wall stress were reduced in all receptor blockade groups compared with CHF values. However, LV fractional shortening was increased only in the dual block group compared with CHF values (29 +/- 3 versus 21 +/- 2, P <.05). Basal LV myocyte percent shortening increased in the dual block group compared with CHF values (3.44 +/- 0.23 versus 2.88 +/- 0.11, P <. 05). Although V(1a) or AT(1) block reduced LV loading conditions, only dual block resulted in improved LV and myocyte shortening.


From time to time reports (1, 2, 3, 4) have been published from this laboratory on the experimental production of Cysticercus tumors of the liver of rats by feeding these animals cat feces containing the eggs of Taenia taeniaeformis ( crassicollis ). Following the ingestion of the eggs by the rats, the shells of the eggs are digested away and the freed oncospheres gain access to the blood vessels of the intestinal wall and are carried to the liver. In their passage from the intestine of the cat to the liver of the rat the larvae may carry with them bacteria which may survive and multiply in the liver tissues. What role, if any, these bacteria play in the reactions of the rat9s liver has not been determined. The presence of the oncosphere in the liver stimulates a proliferative tissue reaction of the host which terminates in the formation of a fibrous-walled cyst about the larva. In other publications (5, 6) it has been shown that Taenia larvae of an early stage of development, when transplanted from the livers of rats to the groins of other rats, may grow and induce the formation of fibrous cyst walls in the subcutaneous tissues. Eight to 27 months after the rats were infested the walls of some of the parasitic cysts, both in the liver and in the groin, showed early sarcomatous changes or were partially or completely transformed into tumors, usually sarcomata.


Neuroimmune-Mediated Alcohol Effects on Ventral Tegmental Area Microglia and Infiltrating Leukocytes Travis Jonathan Clarke Neuroscience Center, BYU Master of Science Microglia are the primary immune cell in the central nervous system and are known as the "resident" macrophages in the central nervous system (CNS). While microglia are classically known as the immune cells of the CNS, their role has more recently been shown to extend far beyond immunity. The effects of ethanol on the brain are closely linked to neuroimmune responses mediated by microglia that are present in the healthy brain from the time of development. Though microglia have been classified as the "resident" immune cells of the CNS, new research suggests that other immune cells may be implicated in the immune response. Normally, the blood-brain barrier (BBB) prevents the infiltration of cells and foreign pathogens from crossing from the periphery into the CNS. However, peripheral monocytes are known to infiltrate the CNS in response to seizures, traumatic brain injury, infection, and multiple sclerosis. Whether or not these cells engraft and become microglia is still a topic of debate. The aim of this study was to determine the effect of acute ethanol on microglia activation and monocyte infiltration into the CNS. We hypothesized that acute EtOH would lead to an increase in neuroinflammation by activating "resident" microglia to an inflammatory polarization and induce the infiltration of macrophages across the BBB. Using the Macrophage FAS-Induced Apoptosis (MaFIA) mouse model (GFP+ on Csf1r promoter), fluorescent microscopy, and flow cytometry we assessed the presence and phenotype of microglia and infiltrating macrophages following 1, 2, and 4 g/kg ethanol at .5, 1, and 2 hours post-injection. By measuring volume/surface area of microglia in the VTA and NAc following EtOH, we found that EtOH caused microglia activation in these areas, and that the microglia are shifting toward an M1 polarization. However, some of our findings were counter to our hypothesis. We found that EtOH, decreases the number of infiltrating monocytes in the VTA and NAc. It is possible that other cells like T and B cells are recruited across the BBB. These findings suggest a neuroimmune connection for acute ethanol use and challenge the dogma that ethanol has exclusively central effects on DA neuronal activity and release. Further research is being performed to examine the implications of this effect, and what effects a conditional knockdown of monocytes has on ethanol intoxication and reward.


Utilization of IP in sensor networks converges them to a unified and simple naming and addressing hierarchy. Thereby, allowing us to be benefited from the existing well established tools and technologies of IP networks. Along with many other unveiled issues, securing IP-USN (IP based Ubiquitous Sensor Network) is of great concern for researchers so that future market satisfaction and demands can be met. Without a proper security framework, it is hard to envisaged IP-USN realm. In this paper we propose a novel Intrusion Detection Framework for IPUSN. According to the best of our knowledge this is the first security framework for any kind of IP based sensor devices. The proposed scheme is fast, lightweight in terms of computation and memory, which make it appropriate for resource constrained sensor devices.


Abstract After the introduction of geothermal power generation technology based on engineering reservoir creation that can be applied on non-volcanic region, industrial need for studies on the efficient and economic execution of costly deep-depth drilling work becomes manifest increasingly. However, since it is very difficult to predict duration and cost of boring work with acceptable reliability because of many uncertain events during the execution, efficient and organized work management for drilling is not easily achievable. Especially, the round trip that discretely occurs because of the abrasion of bit takes more time as the depth goes deeper and it has a great impact on the work performance. Therefore, a technology that can simulate the occurrence timing and depth of round trip in advance and therefore optimize them is essentially required. This study divided the abrasion state of bit into eight steps for simulation cases and developed a forecast algorithm, i.e., TOSA which can analyze the depth and timing of round trip occurrence. A methodology that can divide a unit section for simulation has been suggested; while the Bourgoyne and Young model has been used for the forecast of drilling rates and bit abrasion extent by section. Lastly, the designed algorithm has been systemized for the convenience of the user.


: Ultra wideband (UWB) technology remains a viable choice for very high speed data communication in future applications involving large bandwidth. For boosting the data communication efficiency and to mitigate the multipath fading issue faced by UWB system with existing narrowband systems, Multiple Input Multiple Output (MIMO) antenna system is used along with UWB. Mutual coupling which must be smaller in value plays a vital role in deciding the efficiency of MIMO antenna and hence it becomes as important aspect. The mutual coupling reduction techniques of various UWB MIMO antennas are surveyed in this bibliometric paper. The bibliometric survey aims to enlighten different types of mutual coupling reduction technique employed in various MIMO antenna like Neutralization lines, Electromagnetic Bandgap Structure, Defected Ground Structures, etc. that support UWB applications. The Scopus database from January 2015 to 16 th December 2020 is used to perform this bibliometric survey on UWB MIMO antennas.


The research aims to better understand how and why the activities of local governments, and their roles in society are valued by communities. Executive summary The research investigates: 1. local government's role as a 'place shaper' and its importance in meeting the needs of citizens that drive their attachment to, and satisfaction with, the areas in which they live 2. the preferences of communities for how their services are delivered at the local level and the ability of local governments to offer flexible and community specific service delivery 3. theories of governance, particularly community beliefs about big versus small government and its role in the market, the appropriate role for the private sector in local service provision, the preferred extent of public participation in government decision making, and preferences for the realisation of public value 4. community knowledge of local government, ranked importance of services which can be delivered by local government in different jurisdictions, and attitudes about amalgamation 5. the attributes of individuals which are theorised to interact with or influence their attitudes and beliefs about each of the areas above, including demographic factors, levels of community participation, person values and political leanings. This report presents the main findings of the 2014 survey.


Abstract Objective: To determine whether a brief, case-based educational intervention improves resident confidence, knowledge, and management of glycemia in hospitalized patients. Research Design and Methods: All 116 medical residents at a large academic medical center were offered a case-based curriculum on the management of inpatient glycemia in fall 2008. Residents on ambulatory and elective rotations were taught in small groups, whereas all others underwent online training. All participants were offered a brief online refresher course in spring 2009. We assessed resident confidence across 9 domains of treating inpatient dysglycemia, knowledge based on 4 questions before the course, a 23-part questionnaire after the intervention, and changes in resident behavior as documented in chart abstractions. Results: One hundred eight (93.1%) residents completed initial training, and 102 (87.9%) completed the refresher course. The share of scores indicating that residents felt "somewhat comfortable" or "completely comfortable" treating inpatient dysglycemia increased from 62.5% before the course to 94.3% (P < 0.001) after the initial intervention and 92.8% (P < 0.001) after the refresher. Knowledge scores improved from 72.2% correct answers to 88.9% (P < 0.001) for the 4 questions asked before and after the course. Across all 23 questions posed after the initial course, residents answered 86.1% correctly and maintained a score of 85.5% after the refresher course. Online-trained residents, at 89.7%, outscored their classroom-trained peers (82.3%; P < 0.001) after the initial course. Chart abstractions did not show any significant changes in managing glycemia. Conclusion: A curriculum on the management of inpatient glycemia was broadly adopted by medical residents at a large academic medical center and led to greater confidence and knowledge among residents. Further expansion to other health care providers and hospitals using a Web-based format and incorporation of updated guidelines is needed to confirm and build on these encouraging results.


A new 7 μs isomer in the drip line nucleus 140Dy was selected from the products of the 54Fe (315 MeV) + 92Mo reaction by a recoil mass spectrometer and studied with recoil ‐ delayed γ‐γ coincidences. Five cascading γ transitions were interpreted as the decay of an Iπ = 8− {v9/2−[514] ⊗ v7/2+[404]} K isomer via the ground state band.


Characterization of myogenic subpopulations has traditionally been performed independently of their functional performance following transplantation. Using the preplate technique, which separates cells based on their variable adhesion characteristics, we investigated the use of cell surface proteins to potentially identify progenitors with enhanced regeneration capabilities. Based on previous studies, we used cell sorting to investigate stem cell antigen-1 (Sca-1) and CD34 expression on myogenic populations with late adhesion characteristics. We compared the regeneration efficiency of these sorted progenitors, as well as those displaying early adhesion characteristics, by quantifying their ability to regenerate skeletal muscle and restore dystrophin following transplantation into allogenic dystrophic host muscle. Identification and utilization of late adhering populations based on CD34 expression led to differential regeneration, with CD34-positive populations exhibiting significant improvements in dystrophin restoration compared with both their CD34-negative counterparts and early adhering cell populations. Regenerative capacity was found to correspond to the level of myogenic commitment, defined by myogenic regulatory factor expression, and the rate and degree of induced cell differentiation and fusion. These results demonstrate the ability to separate definable subpopulations of myogenic progenitors based on CD34 expression and reveal the potential implications of defining myogenic cell behavioral and phenotypic characteristics in relation to their regenerative capacity in vivo.


The recent WSNet [1] is a new model compression method through sampling filterweights from a compact set and has demonstrated to be effective for 1D convolutionneural networks (CNNs). However, the weights sampling strategy of WSNet ishandcrafted and fixed which may severely limit the expression ability of the resultedCNNs and weaken its compression ability. In this work, we present a novel auto-sampling method that is applicable to both 1D and 2D CNNs with significantperformance improvement over WSNet. Specifically, our proposed auto-samplingmethod learns the sampling rules end-to-end instead of being independent of thenetwork architecture design. With such differentiable weight sampling rule learning,the sampling stride and channel selection from the compact set are optimized toachieve better trade-off between model compression rate and performance. Wedemonstrate that at the same compression ratio, our method outperforms WSNetby6.5% on 1D convolution. Moreover, on ImageNet, our method outperformsMobileNetV2 full model by1.47%in classification accuracy with25%FLOPsreduction. With the same backbone architecture as baseline models, our methodeven outperforms some neural architecture search (NAS) based methods such asAMC [2] and MNasNet [3].


BACKGROUND
The aim of this paper was to explore the efficacy of modified electroconvulsive therapy (MECT) combined with risperidone oral solution in the treatment of agitation in the acute stage of epilepsy, and the effects of insulin-like growth factor-1 mRNA and protein expression.

METHODS
Forty-six cases with seizures and agitation in the acute stage were included from February 2012 to February 2014. This study was approved by the ethics committee in our hospital. Patients were divided randomly into the experimental (23 cases) and control (23 cases) groups. The patients in the experimental group were treated with MECT combined with risperidone oral solution. The patients in the control group were treated with risperidone oral solution. The Positive and Negative Symptom Scale (PANSS) score and Treatment-Emergent Symptom Scale (TESS) score were compared before and after treatment. The insulin-like growth factor-1 (IGF-1) protein and mRNA expression level were detected with enzyme-linked immunosorbent assay (ELISA) and qRT-PCR, respectively.

RESULTS
There were no significant differences on positive and negative symptom scores or total score in the two groups before treatment (P>0.05). After treatment, the positive symptom score, negative symptom score, and total score all decreased in both groups, and the decrease was more obvious in the experimental group (P<0.05). After treatment, TESS scores of the experimental group were significantly lower than those of the control group (P<0.05). In the experimental group, the total efficiency was significantly higher than that in the control group (P<0.05). Before treatment, there were no significant differences in the expression levels of IGF-1 protein or mRNA in the two groups (P>0.05), while after treatment the expression levels of IGF-1 protein and mRNA decreased in both groups. However, the decrease was more obvious in the experimental group. The differences were all significant for scores (P<0.05).

CONCLUSIONS
The combined application of MECT and risperidone oral solution in the treatment of agitation can improve the clinical efficacy to some extent.


BACKGROUND
Heat shock protein (HSP) 47, a collagen-specific molecular chaperone, is involved in the processing and/or secretion of procollagen. HSP47 is consistently and dramatically upregulated in a variety of fibrotic diseases. The aim of this study was to compare HSP47 expression in normal human buccal mucosa and oral submucous fibrosis (OSF) specimens and further to explore the potential mechanisms that may lead to induce HSP47 expression.

METHODS
The mRNA levels of HSP47 from fibroblasts cultured from 20 OSF and 10 normal buccal mucosal fibroblasts (BMFs) were evaluated by reverse transcription polymerase chain reaction. The effect of arecoline, the major areca nut alkaloid, was added to explore the potential mechanisms that may lead to induce HSP47 expression. Furthermore, mitogen-activated protein kinase kinase (MEK) inhibitor U0126, phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002, p38 inhibitor SB203580, cyclo-oxygenase-2 (COX-2) inhibitor NS-398, and glutathione precursor N-acetyl-l-cysteine were added to find the possible mechanisms.

RESULTS
OSF demonstrated significantly higher HSP47 mRNA expression than BMFs (P < 0.001). Arecoline was also found to elevate HSP47 mRNA expression in a dose-dependent manner (P < 0.05). The amount of HSP47 was about 3.7-fold at a concentration level of 80 microg/ml arecoline when compared with control (P < 0.05). In addition, pre-treatment with pharmacologic agents markedly inhibited the arecoline-induced HSP47 mRNA expression (P < 0.05).

CONCLUSIONS
Taken together, HSP47 is significantly upregulated in OSF from areca quid chewers and HSP47 expression induced by arecoline in fibroblasts may be mediated by MEK, PI3K, and COX-2 signal transduction pathways.


The paper is devoted to several examples of control algorithm development for two-wheeled double-track robot and low-tonnage vessel-catamaran with two Azipods that show practical aspects of the application of one nonlinear system control method — terminal state method. This method, developed by the authors of the present paper, belongs to the class of methods for inverse dynamics problem solving. Mathematical models of control objects in the form of normal systems of third-order nonlinear differential equations for the wheeled robot and seventh-order ones for the vessel are presented. Design formulas of the method in general form for terminal and stabilizing controls are shown. A routine of obtaining calculation expressions for control actions is shown. Results of computer simulation of bringing the robot to a given point in a given time, as well as bringing the vessel to a given course during a "strong" maneuver, are described.


The past decade has seen significant advances in imaging techniques used to measure structure and function in the human brain and many of these have direct relevance to psychiatry. Psychiatric disorders clearly pertain to brain function, however the underlying biology of these putative dysfunctions remains obscure. From a research perspective integrated use of novel imaging techniques in conjunction with clinical assessments now affords an opportunity to advance our understanding of the pathophysiology of psychiatric conditions by allowing the in vivo investigation of abnormalities of brain function as they relate to changes in cognition, mood and behaviour. Whilst most of these imaging techniques are still very much entrenched in the research domain, it is important that clinicians understand the benefits of these new technologies while also appreciating their limitations. These imaging techniques are constantly evolving and hold significant potential to one day provide clinical insights that inform diagnosis and management.


Discrete event simulation has been applied to a wide range of applications areas due to its ability to represent stochastic systems over time. Maintenance, particularly field maintenance, is complex due to the interaction of different sub-systems of use, maintenance, repair and inventory and the conflicting demands of minimizing cost and maximizing availability. The area of simulation of maintenance systems receives little treatment in the literature and tends to focus on reliability modeling of individual assets. The work presented here documents research to fill this gap by specifying, creating and testing simulation functionality to rapidly model field maintenance systems.


INTRODUCTION
Lower respiratory tract infections (LRTI) are a substantial threat for children worldwide. Currently, there is a lack of knowledge about the burden and etiology of LRTI in children under five years of age in Indonesia.

METHODOLOGY
We have systematically searched the available English and Indonesian scientific literature to review and summarize data on LRTI and LRTI-associated invasive disease, and bacterial carriage in the upper respiratory tract in children under five years of age in Indonesia.

RESULTS
Overall, data on the burden and etiology of LRTI in children under five years of age in Indonesia is very limited. The data are primarily collected in Java. Data from other parts of Indonesia, including Sumatra, Kalimantan, and Sulawesi, are scarce. The case fatality rate (CFR) of LRTI in children under five years of age in Indonesia was 0.11%. Influenza was the most commonly reported viral etiological agent of LRTI in children under five years of age in Indonesia. Klebsiella pneumoniae was the most frequently reported bacterial agent of LRTI. Streptococcus pneumoniae showed the highest carriage rates.

CONCLUSIONS
Surveillance and diagnostic studies are urgently needed and should be conducted in different parts of Indonesia to improve insight in the burden and etiology of LRTI in Indonesia. These data are pivotal to increase the effectiveness of public health strategies, including vaccination and prevention of antimicrobial resistance.


Chemokines are required for leukocyte recruitment and appropriate host defense and act through G protein-coupled receptors (GPCRs), which induce downstream signaling leading to integrin activation. Although the α and β subunits of the GPCRs are the first intracellular molecules that transduce signals after ligand binding and are therefore indispensable for downstream signaling, relatively little is known about their contribution to lymphocyte function-associated antigen 1 (LFA-1) activation and leukocyte recruitment. We used knockout mice and short hairpin RNA to knock down guanine nucleotide binding protein (GNB) isoforms (GNB1, GNB2, GNB4, and GNB5) in HL60 cells and primary murine hematopoietic cells. Neutrophil function was assessed by using intravital microscopy, flow chamber assays, and chemotaxis and biochemistry studies. We unexpectedly discovered that all expressed GNB isoforms are required for LFA-1 activation. Their downregulation led to a significant impairment of LFA-1 activation, which was demonstrated in vitro and in vivo. Furthermore, we showed that GPCR activation leads to Ras-related C3 botulinum toxin substrate 1 (Rac1)-dependent activation of both phospholipase C β2 (Plcβ2) and Plcβ3. They act nonredundantly to produce inositol triphosphate-mediated intracellular Ca(2+) flux and LFA-1 activation that support chemokine-induced arrest in vivo. In a complex inflammatory disease model, Plcβ2-, Plcβ3-, or Rac1-deficient mice were protected from lipopolysaccharide-induced lung injury. Taken together, we demonstrated that all Gnb isoforms are required for chemokine-induced downstream signaling, and Rac1, Plcβ2, and Plcβ3 are critically involved in integrin activation and leukocyte arrest.


With the introduction of lithium and increasing evidence that bipolar disorder is a biogenetic condition, changes have occurred in the diagnosis and treatment of bipolar disorder. Cross-cultural studies indicate that in the United States there is a tendency to overuse the diagnosis of schizophrenia when bipolar may be indicated. Both disorders have psychotic symptoms, rendering diagnostic confusion possible. This paper describes the characteristics of bipolar disorder, explanatory theories and treatment. A medical model of treatment is preferred. Issues of concern to social workers are addressed.


At present, there is a growing need to accelerate the development of web applications and to support continuous evolution of web applications due to evolving business needs. The object persistence capability and web interface generation capability in contemporary MVC (Model View Controller) web application development frameworks and model-to-code generation capability in Model-Driven Development tools has simplified the modelling of business objects for developing web applications. However, there is still a mismatch between the current technologies and the essential support for high-level, semantic-rich modelling of web-ready business objects for rapid development of modern web applications. Therefore, we propose a novel concept called Smart Business Object (SBO) to solve the above-mentioned problem. In essence, SBOs are web-ready business objects. SBOs have high-level, web-oriented attributes such as email, URL, video, image, document, etc. This allows SBO to be modelled at a higher-level of abstraction than traditional modelling approaches. A lightweight, near-English modelling language called SBOML (Smart Business Object Modelling Language) is proposed to model SBOs. We have created a toolkit to streamline the creation (modelling) and consumption (execution) of SBOs. With these tools, we are able to build fully functional web applications in a very short time without any coding.


underwent ELISPOT assay and flow cytometric analysis after in vitro stimulation with a H-2D(b)-restricted epitope peptide (aa1629–1637). RESULTS: Immunized mice showed perfect protection against recombinant vaccinia virus challenge. CD8+ T cells from immunized mice revealed aa1629–1637-specific IFNc and CD107a responses which were stronger compared to those induced by the immunization with liposomes coupled with the peptide aa1629–1637. Vaccination experiments with HLA-A2 and HLA-A24 transgenic mice and in vitro stimulation study of PBMC from HLA-A2 and HLA-A24 positive HCV patients are now underway. CONCLUSION: The antigenic protein on the surface of liposomes seems to be cross-presented to CTL as we previously demonstrated (PLoS ONE 5:e15225, 2010). This type of vaccine seems to have the potential to overcome MHC restriction and can be applied as a universal vaccine.


The validity of determining the working times of polymeric restorative materials with the use of rheologic methods in the laboratory has been investigated by measuring the adaptation of polymeric restorative materials to artificial cavities when inserted at 30-second time intervals during their setting reactions. There was a significant deterioration in adaptation during the working times which suggests that small changes in viscosity early in the setting reactions radically affect the materials' mobility.


Rolling Shutter (RS) cameras are used across a wide range of consumer electronic devices-from smart-phones to high-end cameras. It is well known, that if a RS camera is used with a moving camera or scene, significant image distortions are introduced. The quality or even success of structure from motion on rolling shutter images requires the usual intrinsic parameters such as focal length and distortion coefficients as well as accurate modelling of the shutter timing. The current state-of-the-art technique for calibrating the shutter timings requires specialised hardware. We present a new method that only requires video of a known calibration pattern. Experimental results on over 60 real datasets show that our method is more accurate than the current state of the art.


ABSTRACT Collin, A., Etienne, S. and Planes, S., 2013. High-energy events, coastal boulder deposits and the use of very high resolution remote sensing. In recent years, coastal boulders have become a trendy proxy in studying high-energy marine inundation events. From their morphology and spatial distribution, authors are able to characterize a singular event in terms of intensity (wave height, flow velocity). Recent post-catastroph studies (e.g. Indian Ocean 2004 and Japan 2011 tsunamis) have demonstrated also the interest of boulder deposits in reconstructing the event kinematics through a multi-proxy approach. But as boulder studies require a statistically robust dataset they are field-time consuming and sometimes fieldwork takes place in remote areas with low facilities. The use of very high resolution remote sensing could overcome some of these limits. In this paper, we evaluate the possibility to identify meter-size coral boulder thrown on a reef flat during the hit of a tropical cyclone. Image analysis allows for the discrimination of major geographical object encountered on coralline islands: submerged coral boulder, emerged coral boulder, perched reef, sand beach. Within emerged boulder population, specific bands available with WorldView-2 images (i.e. red and NIR2 band) allow the spectral discrimination and mapping of fresh and weathered elements.


Locating transition states is crucial for investigating transition mechanisms in wide-ranging phenomena, from atomistic to macroscale systems. Existing methods, however, can struggle in problems with a large number of degrees of freedom, on-the-fly adaptive remeshing and coarse-graining, and energy landscapes that are locally flat or discontinuous. To resolve these challenges, we introduce a new double-ended method, the Binary-Image Transition State Search (BITSS). It uses just two states that converge to the transition state, resulting in a fast, flexible, and memory-efficient method. We also show that it is more robust compared to existing bracketing methods that use only two states. We demonstrate its versatility by applying BITSS to three very different classes of problems: Lennard-Jones clusters, shell buckling, and multiphase phase-field models.


Biomass energy has the characteristics of renewable and decentralized and plays a certain role in mitigating climate change. Now it is considered to be a very important renewable energy and has great potential for development. Based on Science Citation Index Expanded and Social Sciences Citation Index databases, this paper retrieved the publication data through topic search using the keywords biomass energy and related words during 2007–2016. This paper investigates the development characteristics in biomass energy research based on bibliometrics methods and data mining techniques. The main purpose of this paper is to explore the knowledge structure and citation landscape in this field. The general development trends, Essential Science Indicators publications characteristics, and leading journals in this area are discussed. The main advantage of this analysis is based on massive data which can, to some extent, reveal the macrostate of the development of the field.


Abstract:Consumption and production of digital goods and services have increased in Indonesia for the past ten years. A fast-growing e-commerce sector and an increase in digital payments supported the strong growth of the digital economy. Although Internet and digital transactions emerged in the late 1980s, the regulatory framework governing digital activities was only introduced in 2008 with the enactment of the Law on Electronic Information and Transactions. The government of Indonesia has relaxed foreign capital restrictions and provided fiscal incentives for digital businesses. Indonesia has also made commitments related to digital business in recent trade agreements in terms of the mutual recognition of consumer protection and cross-border data transfer. To encourage the use of ICT in public service, Indonesia introduced the 100 Smart City programme and has begun the implementation of electronic-based public service and operation (e-government). The government accelerated digital transformation during the COVID-19 pandemic by increasing the budget allocations for ICT in 2020 and 2021. To further accelerate digital transformation, the government needs to focus on digital literacy, nationwide integrated infrastructure, regulatory and institutional mechanisms and the innovation ecosystem.


Osteoclasts are resident cells of the bone that are primarily involved in the physiological and pathological remodeling of this tissue. Mature osteoclasts are multinucleated giant cells that are generated from the fusion of circulating precursors originating from the monocyte/macrophage lineage. During inflammatory bone conditions in vivo, de novo osteoclastogenesis is observed but it is currently unknown whether, besides increased osteoclast differentiation from undifferentiated precursors, other cell types can generate a multinucleated giant cell phenotype with bone resorbing activity. In this study, an animal model of calvaria-induced aseptic osteolysis was used to analyze possible bone resorption capabilities of dendritic cells (DCs). We determined by FACS analysis and confocal microscopy that injected GFP-labeled immature DCs were readily recruited to the site of osteolysis. Upon recruitment, the cathepsin K-positive DCs were observed in bone-resorbing pits. Additionally, chromosomal painting identified nuclei from female DCs, previously injected into a male recipient, among the nuclei of giant cells at sites of osteolysis. Finally, osteolysis was also observed upon recruitment of CD11c-GFP conventional DCs in Csf1r−/− mice, which exhibit a severe depletion of resident osteoclasts and tissue macrophages. Altogether, our analysis indicates that DCs may have an important role in bone resorption associated with various inflammatory diseases.


Lamb chops and steaks from fresh (F) or vacuum packaged (VP) racks, loins and legs were packaged in polyvinyl chloride (PVC) film or vacuum packaged in high oxygen-barrier (HOB) film. Use of previously vacuum packaged (PVP) cuts did not affect overall appearance of rib or loin chops during subsequent retail display but HOB film-packaged leg steaks from PVP cuts had lower overall appearance scores than did leg steaks from F cuts. Prior VP storage negatively affected flavor desirability and odor at the conclusion of retail display (4 days in PVC or 10 or 15 days in HOB film). Pseudomonas spp. were a dominant part of the microflora of PVC-wrapped chops while L. cellobiosus was a dominant part of the microflora of HOB-wrapped chops.


Molten iron corrosion resistance of silicon-corundum-silicon nitride composites were investigated using corundum, silicon nitride, clay and silicon powder as the main starting materials by static crucible method. The corrosion mechanism of the composites was analyzed by means of scanning electron microscope (SEM with EDS). The results revealed that corundum-silicon nitride composites possessed good molten iron corrosion behavior and the active oxidation of silicon nitride was the main reason for loose structure of the corroded specimen; The composites produced a dense layer by addition of silicon, which made superior molten iron corrosion resistance behavior.


This article elucidates the Typological Primacy Model (TPM; Rothman, 2010, 2011, 2013) for the initial stages of adult third language (L3) morphosyntactic transfer, addressing questions that stem from the model and its application. The TPM maintains that structural proximity between the L3 and the L1 and/or the L2 determines L3 transfer. In addition to demonstrating empirical support for the TPM, this article articulates a proposal for how the mind unconsciously determines typological (structural) proximity based on linguistic cues from the L3 input stream used by the parser early on to determine holistic transfer of one previous (the L1 or the L2) system. This articulated version of the TPM is motivated by argumentation appealing to cognitive and linguistic factors. Finally, in line with the general tenets of the TPM, I ponder if and why L3 transfer might obtain differently depending on the type of bilingual (e.g. early vs. late) and proficiency level of bilingualism involved in the L3 process.


Terminal deoxynucleotidyl transferase (TdT) was purified from calf thymus and a monoclonal antibody-producing clone was produced by the fusion of mouse myeloma cells and spleen cells of mice immunized with the purified enzyme. The antigens recognized by an immunoadsorbent column revealed TdT, whose molecular weight was 62 kDa. The extensive study of TdT in 196 patients with hematological disorders was done. The results from immunofluorescent analysis corresponded well to the results of biochemical assays of this enzyme. This monoclonal antibody will provide a useful means for the survey of leukemia and lymphoma patients.


Critical theory and research has shown that subjects carry gendered meanings. Numbers opting for Religious Studies (RS) have remained skewed towards girls. Drawing from post-structuralism and masculinities theory, this article critically analyses data from interviews with a group of key stage four boys who had opted for Religious Studies in contrast to the majority of their male peers. Interview data demonstrate that these boys were able to use Religious Studies as a discursive resource, constituting themselves as emergent critical ethical subjects and developing their own relationship to existential questions of meaning and purpose. The boys demonstrated reflexive self awareness as they were also able to negotiate socially successful identities through their relationship to the dominant masculinising forces of sport, physicality and authority and engage with Religious Studies. This article concludes that subjects such as Religious Studies which create spaces for criticality also act to create masculine subjectivities outside of restrictive gendered norms.


The Australian government's strict censorship regime of the mid-twentieth century banned a range of imported books, from popular to pornographic to literary titles. Drawing on the archived censor reports of the committee, this article will argue that Australia's Commonwealth Literature Censorship Board is best understood within a tradition of conservative thinking about literature's social function which can be traced back to Matthew Arnold. This paper examines the banning of James Baldwin's Another Country as an example of politically conservative anxieties about race and sexuality influencing the impetus behind the censor's decisions. It is argued that the Australian censorship project was underwritten by an ideological notion of what literature is, and how it should serve the interests of the state.

To cite this paper please use the following details: Gawen, N. (2019), 'Conservative Censors, Banned Books: Reading the Reports of Australia's Commonwealth Literature Censorship Board', Reinvention: an International Journal of Undergraduate Research, Volume 12, Issue 1, https://reinventionjournal.org/article/view/432/391. Date accessed [insert date]. If you cite this article or use it in any teaching or other related activities please let us know by e-mailing us at email@example.com.


Background: Apoptosis is a vital process for normal cell turnover, proper development and functioning of the immune system, embryonic development and chemical-induced cell death. Objectives: The present review aims to spotlight on the stages and mechanisms of programmed cell death. Apoptosis, known as programmed cell death, is a homeostatic mechanism that generally occurs during development and aging in order to keep cells in tissue. It can also act as a protective mechanism, for example, in immune response or if cells are damaged by toxin agents or diseases. In cancer treatment, drugs and irradiation used in chemotherapy leads to DNA damage, which results in triggering apoptosis through the p53 dependent pathway in cancer treatment, drugs and irradiation used in chemotherapy leads to DNA damage, which results in triggering apoptosis through the p53 dependent pathway. Corticosteroids can cause apoptotic death in a number of cells. A number of changes in cell morphology are related to the different stages of apoptosis, which includes nuclear DNA fragmentation, cell shrinkage, chromatin condensation, membrane blebbing, and the formation of apoptotic bodies. There are three pathways for apoptosis, the intrinsic (mitochondrial) and extrinsic (death receptor) are the two major paths that are interlinked and that can effect one another. Conclusion: It can be concluded that apoptosis is a homeostatic mechanism that generally occurs during development and aging in order to keep cells in tissue. Drugs and irradiation used in chemotherapy leads to DNA damage, which results in triggering apoptosis through the p53 dependent pathway. The apoptosis, stages are includes nuclear DNA fragmentation, cell shrinkage, chromatin condensation, membrane blebbing, and the formation of apoptotic bodies. There are three pathways for apoptosis.


New cerebral monitoring techniques allow direct measurement of brain oxygenation and metabolism. Investigation using these new tools has provided additional insight into the understanding of the pathophysiology of acute brain injury and suggested new ways to guide management of secondary brain injury. Studies of focal brain tissue oxygen monitoring have suggested ischemic thresholds in focal regions of brain injury and demonstrated the interrelationship between brain tissue oxygen tension (P bt O 2 ) and other cerebral physiologic and metabolic parameters. Jugular venous oxygen saturation (SjVO 2 ) monitoring may evaluate global brain oxygen delivery and consumption, providing thresholds for detecting brain hypoperfusion and hyperperfusion. Furthermore, critically low values of P bt O 2 and SjVO 2 have also been predictive of mortality and worsened functional outcome, especially after head trauma. Cerebral microdialysis measures the concentrations of extracellular metabolites which may be relevant to cerebral metabolism or ischemia in focal areas of injury. Cerebral blood flow may be measured in the neurointensive care unit using continuous methods such as thermal diffusion and laser Doppler flowmetry. Initial studies have also attempted to correlate findings from advanced neuromonitoring with neuroimaging using dynamic perfusion computed tomography, positron emission tomography, and Xenon computed tomography. Additionally, new methods of data acquisition, storage, and analysis are being developed to address the increasing burden of patient data from neuromonitoring. Advanced informatics techniques such as hierarchical data clustering, generalized linear models, and heat map dendrograms are now being applied to multivariable patient data in order to better develop physiologic patient profiles to improve diagnosis and treatment.