We report a case of mediastinal lymph node metastasis from rectal cancer successfully treated by carbon ion radiotherapy. A 65-year-old woman underwent sigmoid colostomy against unresectable rectal cancer. After chemoradiotherapy, primary rectal cancer became resectable and low anterior resection was performed. Curative local resection was done and chemoradiotherapeutic effect was grade 2. Chemotherapy after the operation wasn't effective enough and the size of the mediastinal lymph node increased. So she underwent carbon ion radiotherapy (52.8 Gy) which markedly decreased the lymph node size (-48%). Multi-modality therapy, such as radiation, chemotherapy, operation and carbon ion radiotherapy was applied. Successfully, locally advanced rectal cancer was resected and distant lymph node metastasis was controllable.


We have enhanced a computational cognitive agent by embodying it with real and simulated bodies operating in real and simulated worlds. This has allowed us to experiment with various ways that embodiment influences the creation and meaning of the agent's beliefs and other terms in its knowledge base, including: symbol-grounding by perception and action; firstperson privileged knowledge; the representation and use of indexicals; having a personal sense of time; and low-level bodily awareness.


HF wave propagation in the turbulent stratified ionosphere is investigated using the multiple phase-screen simulation method. For waves incident along the axis of the background stratification, generalized parabolic equations for the modified complex amplitude u are derived which are applicable even in the strong scattering case. Based on these parabolic equations, several one-dimensional random phase screens are numerically generated to represent the effect of the random irregularities on the wave. For plane wave incidence, various statistical properties of the field, such as correlation, power spectrum, scintillation index, etc., can be directly computed using spatial averaging under the ergodicity assumption. The simulation method is also used to examine the effect of the velocity profile on the drift pattern on the ground.


Ovarian cancer is the fifth most common type of cancer in females; however, its asymptomatic progression and the lack of an efficient screening strategy leads to late diagnosis. The present study aimed to investigate the expression levels of cluster of differentiation (CD)146 and vascular endothelial growth factor A (VEGFA) in epithelial ovarian cancer, and their clinical significance. A total of 52 ovarian samples were tested, of which 22 were from patients with epithelial ovarian cancer and 30 were from non-cancer patients. The relative gene expression of CD146 and VEGFA was quantified using reverse transcription-quantitative polymerase chain reaction analysis. Western blotting was used to determine the protein expression levels. The relative gene expression levels of CD146 and VEGFA in tumor tissues were significantly increased compared with the control (4.92±0.44 vs. 1.05±0.06 and 3.08±0.17 vs. 1.06±0.07, P<0.01). The protein expression levels of CD146 and VEGFA in tumor tissue were also significantly increased compared with the control (0.70±0.02 vs. 0.41±0.07 and 0.54±0.01 vs. 0.26±0.01, P<0.01). There was a positive correlation between the expression levels of CD146 and VEGFA genes (r=0.78) and between the two proteins (r=0.69). Dot density frequency analysis indicated that CD146 and VEGFA were specifically present in tumor tissues. In conclusion, CD146 and VEGFA are co-overexpressed in ovarian cancer; their potential as tumor biomarkers or therapeutic targets for the treatment of ovarian cancer requires further investigation.


Objective The prognostic importance of left ventricular hypertrophy (LVH) on renal impairment has not been addressed previously. We investigated whether LVH determines renal outcomes in patients with high cardiovascular risk. Methods We retrospectively studied 6163 men with high cardiovascular risk (68 ± 13 years, 23% with coronary artery disease, 34% with diabetes, 83% with hypertension and 30% smokers) followed for a period of 14 years. Left ventricular mass index was assessed at baseline, whereas kidney function and blood pressure levels were determined at both baseline and the end of the follow-up period. Renal outcomes were doubling of serum creatinine, estimated glomerular filtration rate (eGFR) below 30 ml/min per 1.73 m2 and incident hemodialysis. Results During the follow-up, 5.8% (n = 356), 7% (n = 429) and 2.7% (n = 165) of men fulfilled the above-mentioned three outcomes, respectively. After adjustment, for each 42 g/m2 (1 SD) increase in left ventricular mass index, there was a rise in risk of all renal outcomes by 45.7% (95% confidence interval 28.5–58.3) for doubling of serum creatinine, 51.9% (95% confidence interval 39.7–65%) for eGFR below 30 ml/min per 1.73 m2 and 58.3% (95% confidence interval 39.7–79.3) for hemodialysis (P < 0.001 for all). Severe LVH (160 < left ventricular mass index ≤ 180 g/m2) compared with non-LVH predicted a significant increase in: doubling of serum creatinine by 103.8%, eGFR-guided outcome by 109.1% and hemodialysis by 74.1%. In those with LVH and impaired kidney function at baseline (GFR <60 ml/min per 1.73 m2) compared with those without such entities, serum creatinine, eGFR and hemodialysis-guided outcomes were increased by four-fold, 15-fold and 16-fold, respectively. Conclusion Increased left ventricular mass is a predictor of subsequent kidney dysfunction and should be considered in renal risk stratification in a broad spectrum of men with high cardiovascular risk.


The detection of frictional heating effects along faults provides key insight into the dynamics of earthquakes and faulting. Thermal maturity of organic matter has been considered a possible fault‐thermometer that records the frictional heat signature of ancient earthquakes. However, whether or not organic matter can mature on the order of seconds, typical earthquake rise time, remains uncertain. Here we present the results of experiments aimed at revealing coal maturation by frictional heat generated at slip velocities representative of natural earthquakes of up to 1.3 m/s. Our results show that coal can mature coseismically in ∼11 seconds at temperatures induced by frictional heat ranging from 26 to 266°C. Even with a temperature rise to only 28.7°C over 15 m displacement in ∼3.2 hours, coal can slightly mature within a shear localized zone. The commonly used kinetic model of vitrinite maturation cannot predict the experimental results. A kinetic model involving the effect of flash temperature at grain contacts and mechanochemical effects on reaction kinetics is necessary to better estimate heat generation along a fault.


Equal channel angular extrusion (ECAE) is used to consolidate amorphous Vitreloy 106a (Zr 58.5 Nb 2.8 Cu 15.6 Ni 12.8 Al 10.3 ) powder into bulk metallic glass. Consolidations are performed on gas atomized powder containing 1280 ppmw oxygen encapsulated in copper cans and 780 ppmw oxygen powder encapsulated in nickel cans in a 90° die-angle tool at temperatures above the glass transition temperature (T g ) but below the rapid crystallization temperature (T x ), in the supercooled liquid region (ΔT). Results show that V106a is successfully consolidated to nominal full density after one extrusion pass. Good particle-to-particle bonding and significant particle deformation are observed in the consolidated alloy. A lower oxygen content is beneficial due to the larger undercooled region and the additional time for processing. The low oxygen content material shows little change in thermal stability after being consolidated when compared to the original powder but fine interparticle cracks are observed in some of the consolidates. ECAE appears to be a viable method for consolidating amorphous metal powders into bulk amorphous metal.


The rapid growth of deep learning (DL) has spurred interest in enhancing log-based anomaly detection. This approach aims to extract meaning from log events (log message templates) and develop advanced DL models for anomaly detection. However, these DL methods face challenges like heavy reliance on training data, labels, and computational resources due to model complexity. In contrast, traditional machine learning and data mining techniques are less data-dependent and more efficient but less effective than DL. To make log-based anomaly detection more practical, the goal is to enhance traditional techniques to match DL's effectiveness. Previous research in a different domain (linking questions on Stack Overflow) suggests that optimized traditional techniques can rival state-of-the-art DL methods. Drawing inspiration from this concept, we conducted an empirical study. We optimized the unsupervised PCA (Principal Component Analysis), a traditional technique, by incorporating lightweight semantic-based log representation. This addresses the issue of unseen log events in training data, enhancing log representation. Our study compared seven log-based anomaly detection methods, including four DL-based, two traditional, and the optimized PCA technique, using public and industrial datasets. Results indicate that the optimized unsupervised PCA technique achieves similar effectiveness to advanced supervised/semi-supervised DL methods while being more stable with limited training data and resource-efficient. This demonstrates the adaptability and strength of traditional techniques through small yet impactful adaptations.


Summary form only given. The author discusses play in World of Warcraft, a popular massively multiplayer online game. World of Warcraft enables self-organizing groups of strangers and friends to collaborate on short-term objectives. Such collaborations may reflect coming changes in globalized work in which we increasingly work with remote others we know little about. In game play, the glue that keeps groups together is the shared objective of completing a "quest" or mission, as well as the shared culture of the game. The game is rich in meaning with a strong narrative, a material culture of weapons, armor, potions, recipes, jewelry, and many other goods, as well as a vibrant economy. Players' backgrounds are diverse but discourse emphasizes understandings about the game rather than players' personal lives. Players learn to be at ease with strangers, to get things done with others they don't know and may never interact with again. The game diminishes some of the impact of things that divide us such as ethnicity, gender, and age, through sharing the game


The class of differential equation eigenvalue problems −y''(x) + x2N+2y(x) = xN Ey(x) (N = −1, 0, 1, 2, 3, ...) on the interval −∞ < x < ∞ can be solved in closed form for all the eigenvalues E and the corresponding eigenfunctions y(x). The eigenvalues are all integers and the eigenfunctions are all confluent hypergeometric functions. The eigenfunctions can be rewritten as products of polynomials and functions that decay exponentially as x → ±∞. For odd N the polynomials that are obtained in this way are new and interesting classes of orthogonal polynomials. For example, when N = 1, the eigenfunctions are orthogonal polynomials in x3 multiplying Airy functions of x2. The properties of the polynomials for all N are described in detail.


In this work, we present a computationally efficient method for selecting experiments that can effectively reduce the uncertainty in gene regulatory networks (GRNs). The proposed method prioritizes potential experiments based on the mean objective cost of uncertainty (MOCU) that is expected to remain after performing the experiments. A network reduction scheme is used to approximately estimate the MOCU at a reduced computational cost without disrupting the ranking of potential experiments. The effectiveness of our method is demonstrated through simulations.


Following the defeat of the revolutions in France, Germany, Italy, Poland and Hungary in 1848 and 1849, many participants of the liberal movements had to flee to escape retaliation. In Europe, Britain was the only safe haven for the refugees: in London perhaps the most interesting group of idealists of many nationalities convened − with the major link between them being their unsuccessful clash with the forces of monarchy in their homelands and their grandiose plans for re-starting the freedom fights. For Marx, Kinkel, Hecker, Kossuth, Mazzini, Ruge London, as one of them put it, offered little bread, but did provide the necessary freedom of speech and that of press. Many deemed it crucial that they succeed in the mobilization of the United States in support of their struggles. In order to mobilize the American public, and, of course, to collect donations for their cause, these (ex-)leaders of the revolutions traveled to the United States sometime in the 1850s and organized extensive lecturing and fundraising tours: Gottfried Kinkel (September 1851 to March 1852), Amand Goegg (December 1851 to July 1852), Kossuth (December 1851 to July 1852), Alberto and Jessie White Mario (October 1858). This paper aims to analyze the historical significance of the lecturing tours by seeking answers to the following questions: 1.) Why did the revolutionary spokespersons unanimously turn to America for inspiration? 2.) What practical benefits did the individual fundraisers hope to gain from their trips? What specific target audiences did they choose for their campaign, and why? 3.) What was the reaction of the American public? 4.) What was the relationship between the travelling revolutionaries themselves? 5.) How can the results of the tours be evaluated from the perspective of the a) individuals b) the ethnic group/political issues they represented c) American general public/political groups? 3,99zl


From the Publisher:
Focused strategies for writing hard-hitting,results-based Web copy The Web is a fascinating and boundaryless marketing mediumand,like any new sales frontier,it has its own set of rules and attitudes for writing successful advertising,marketing,and sales copy. The Online Copywriter's Handbook is a clear,practical,and authoritative guide to key differences between writing for the Internet and writing for print. It covers general fundamentals of writing effective Web copy plus specific Web copywriting tasks from websites and home pages to Internet direct mail,banner ads,and more.
Numerous innovations and benefits include: Appendixes of helpful websites and other resources Time-tested fundamentals of writing effective copy Guidelines for E-zines and Web-based documents

America's Top Copywriter Reveals How to Grab Attention—and Drive Sales—with Customer-Focused,Results-Based Web Copy!

In The Online Copywriter's Handbook,Robert Bly—one of the world's most honored copywriters and bestselling author of The Copywriter's Handbook—turns his attention to the untapped,unlimited marketplace of the Internet. The result? The first book to apply long-established persuasive techniques to the interactive capabilities and unique possibilities of the Web.

Though the psychological hot buttons and decision drivers may be similar,the techniques of persuasion online are different—often dramatically different! Look to The Online Copywriter's Handbook for inside tips on how to write brilliant copyfor:

Websites
Home pages
Internet direct mail
Banner ads
Landing pages
E-zines
Web-based documents
And more!

Nobody knows how to grab buyers' attention and make them want to buy better than Robert Bly! Get The Online Copywriter's Handbook and let a master copywriter show you how to take your online copywriting to the next level of effectiveness,with success—and profitable results!

"Most seminars,books,and articles on Web marketing focus on technology or graphics. But on the Internet,as in print,it is the words that communicate your offer and persuade people to buy. . . . By reading this book,you will learn how to write effectively for this new medium using the time-tested principles of persuasion. "

—From the Introduction

The World Wide Web is a vast frontier for marketers and marketing writers. And while the Web has clearly changed the paradigms of what constitutes powerful copy,too many copywriters make the mistake of thinking that the foundations of effective copy have also been transformed.

Robert Bly knows better. A veteran with more than twenty years' experience in the battlefield of marketing and advertising,Bly is a master at crafting messages that make customers take notice—and take out their wallets. His latest guide,The Online Copywriter's Handbook, outlines a clear-headed,practical approach to translating marketing's most time-honored,results-driven strategies and principles to the online environment. Packed with examples of online copy that soars,this must-read Web marketing manifesto provides:

The nine essential characteristics of persuasive online copy
Eight steps to consider before writing website copy
The tools you need to create an effective home page
Major components of an Internet direct-mail piece—and how to make yours stand out
Eleven can't-miss ways to transfer powerful offline copy to the Web
Tried and true e-zine techniques for increasing both credibility and frequency
Nine common banner ad mistakes,along with proven click-through tips from the pros
Direct-mail strategies to drive business-to-business traffic to your website
A resource guide with information on search engines,e-list brokers,and more

Web marketers,temporarily blinded by graphic gadgetry and interactive hoopla,have quickly come to the conclusion that copy is still king. Let The Online Copywriter's Handbook show you how to apply decades of successful direct-marketing techniques to writing for the Web to make all of your online copywriting more focused and hard-hitting—and measurably more persuasive!


High power laser + pulsed gas metal arc welding(GMAW)hybrid welding is an advanced welding process in manufacturing light weight structures.For aluminium alloys,its reflection rate is much higher than steels,thus,the previous keyhole model for steels has to be modified.With considering the characteristics of high power laser+pulsed GMAW hybrid welding of aluminium alloys,the effect of metal steam plume and laser-induced plasma on the laser power absorption inside keyhole is dealt with,the previous model of keyhole profile is improved,and the calculation accuracy of laser-induced keyhole profile is enhanced.The distribution parameters of volumetric heat source for laser beam are calibrated by using the calculated keyhole profile.The predicting model of weld shape and size is established to determine the weld dimensions in hybrid welding of aluminium alloys.Through numerical analysis of temperature field and weld geometry,the data about the weld formation in hybrid welding of aluminium alloys are obtained under different conditions.High power laser + pulsed gas metal arc hybrid welding experiments validate that the calculated results are in good agreement with experimentally measured ones.


Previous studies have shown that restaurant employees who use tip-enhancing behaviors such as smiling, introducing oneself by one's name or writing "thank you" on the bill receive more tips. The aim of this study is to evaluate the impact of a training intervention about tip-enhancing behaviors on the amount of tips received by restaurant employees. The sample of this study comprised 143 employees working in 62 restaurants. Sixty-nine participants took part in the training intervention and 74 were in the control condition. After the training intervention, the amount of tips received by the employees was tracked over 5 days. Results showed that participants who followed the training intervention used more tip-enhancing behaviors than the participants in the control group, that a higher use of tip-enhancing behaviors was related to higher amount of tips and that the effect of the training intervention on the amount of tips was fully mediated by an increase in the use of tip-enhancing behaviors.


The discovery of microRNAs (miRNAs), about a decade ago, has completely changed our understanding of the complexity of gene regulatory networks. It has already been shown that they are abundantly found in many organisms and can regulate hundreds of genes in post-transcriptional level. To elucidate the individual or co-operative effects of miRNAs, it is required to place them in the overall network of gene regulation and link them to other pathways and systems-level processes. One key step in this effort is predicting targets of individual miRNAs. Although current tools are helpful in predicting miRNA-mRNA binding to a considerable extent, they are not able to model many-to-many relationships between miRNAs and their targets using solely sequence information. Therefore, other types of information sources have been employed for better prediction of these functional relationships. This report focuses on the state-of-the-art solutions and current challenges on mining miRNA-related data to discover the systems-level role of miRNAs, with an emphasis on the integration of different information sources. We aim to provide new insights for fusion of different types of biochemical and experimental information sources which may facilitate functional analysis of miRNAs.


The electrical insulating materials used on spacecraft power systems degrade due to their exposure to a hostile environment. This environment consists of high energy protons, electrons and space plasma. The extreme thermal changes when the spacecraft is facing the Sun or when eclipsed by the Earth presents another cause for the degradation of the material. The alternating current properties, which indicate the quality and stability of the electrical insulation, are: changes in capacitance and the dissipation factor of the insulating material. The variation of these parameters with changes in temperature, vacuum pressure and frequency are investigated.<<ETX>>


The high incidences of bone metastasis in patients with breast cancer, prostate cancer and lung cancer still remains a puzzling issue. The "seeds and soil" hypothesis suggested that bone marrow (soil) may provide a favorable "niche" for tumor cells (seed). When seeking for effective ways to prevent and treat tumor bone metastasis, most researchers focus on tumor cells (seed) but not the bone marrow microenvironment (soil). In reality, only a fraction of circulating tumor cells (CTCs) could survive and colonize in bone. Thus, the bone marrow microenvironment could ultimately determine the fate of tumor cells that have migrated to bone. Bone marrow adipocytes (BMAs) are abundant in the bone marrow microenvironment. Mounting evidence suggests that BMAs may play a dominant role in bone metastasis. BMAs could directly provide energy for tumor cells, enhance the tumor cell proliferation, and resistance to chemotherapy and radiotherapy. BMAs are also known for releasing some inflammatory factors and adipocytokines to promote or inhibit bone metastasis. In this review, we made a comprehensive summary for the interaction between BMAs and bone metastasis. More importantly, we discussed the potentially promising methods for the prevention and treatment of bone metastasis. Genetic disruption and pharmaceutical inhibition may be effective in inhibiting the formation and pro-tumor functions of BMAs.


Although most advanced cancers are incurable, the majority of testicular germ cell tumors can be cured using cisplatin‐based combination chemotherapy. The nucleotide excision repair (NER) pathway removes most DNA adducts produced by cisplatin, and the low levels of NER in testis tumor cells may explain why these cancers are curable. Three NER proteins: ERCC1, XPF, and XPA, are present at low levels in testis tumor cell lines, and addition of these proteins to protein extracts of testis tumor cells increases their in vitro DNA repair capacity to normal levels. The aim of this study was to identify the mechanism responsible for the low levels of these DNA repair proteins. The levels of the mRNA transcripts for ERCC1, XPF, and XPA were measured in a panel of 14 different human cancer cell lines, using real‐time PCR. Three ERCC1 splice variants were identified and quantitated. Three alternative transcription start points (TSPs) were identified for ERCC1 but none were testis‐specific. The significantly lower levels of ERCC1, XPF, and XPA protein in testis tumor cell lines cannot be explained solely by differences in transcriptional efficiency or mRNA stability. For ERCC1, post‐transcriptional control by alternative splicing does not account for the testis‐specific low levels of protein expression. Pulse‐chase experiments showed that the half‐life of ERCC1 protein in a testis tumor cell line was not significantly different to that in a prostate cancer cell line. Taken together, these results suggest that constitutive levels of these DNA repair proteins are controlled at the level of translation. J. Cell. Biochem. 97: 1121–1136, 2006. © 2005 Wiley‐Liss, Inc.


The article is devoted to the topical issue of improving the special physical training of cadets of higher military educational institutions by means of military-applied sports. The task of forming the psychophysiological readiness of officers for future military-professional activity in the process of training in a higher military educational institution is solved with the help of a number of disciplines of professional-oriented (military-professional) training, the leading of which is special physical training. According to the authors, classes in the sections of military-applied sports help prepare cadets for future military-professional activities. Military-sports all-around is one of the military-applied sports. The purpose of the study is to investigate the impact of military-sports all-around classes on the indicators of special physical training of cadets of higher military educational institutions. Materials and methods. The study was conducted in the period from September 2017 to October 2019 on the basis of Ivan Kozhedub Kharkiv National University of the Air Force and was aimed at determining the indicators of special physical fitness of cadets. The study involved 95 cadets of the control group, who studied under the current system of physical training and 36 cadets of the experimental group, who were engaged in the section of military-sports all-around. The age of the subjects ranged from 17 to 26 years. During the experiment, there was a study of indicators of special physical training of cadets by the results of special physical exercises (complex dexterity exercise, complex strength exercise, forced march for 5 km) and determining of the average score of special physical training. Results and discussion. The results of the study show an improvement in the results of the representatives of the experimental group in relation to the respondents of the control group: a complex exercise for dexterity by 2.1% (p <0.01), a complex strength exercise by 5.6% (p <0.01), a forced march for 5 km at 1.1% (p <0.01). The average score of special physical training of the experimental group of cadets after the experiment is statistically significantly better than the score of the control group representatives by 8.8% (p <0.05) and corresponds to the score "excellent". Conclusion. Military-sports all-around classes allow to improve the indicators of special physical training of university cadets


: The separation and purification process of alkaloids faces great challenges of pollution, high energy consumption and low continuity. In this study, the effects of ceramic microfiltration (MF) membrane (membrane pore size of 0.50 µ m, 0.20 µ m, 0.05 µ m) and organic ultrafiltration (UF) membrane (membrane molecular weight cut-off of 10 KDa and 1 KDa) on the separation and purification of Caulis sinomenii extract solution in pilot scale were studied. The cleaning effects of different cleaning methods (pure water, 1% HCl-NaOH, 1% sodium hypochlorite) were investigated. The experimental results indicated that 0.05 µ m ceramic membrane and 1 kDa UF membrane have higher sinomenine hydrochloride (SH) permeabilities and total solids (TS) removal rates. The ceramic membrane was circulating cleaned by 1% sodium hypochlorite solution for 1 h; the membrane flux can be restored to more than 90% of the original, the membrane flux of 1 kDa UF membrane can be restored to 99.2% of the original by pure water washing. From the above study, the optimal technic parameters was determined in which 0.05 µ m ceramic MF membrane and 1 kDa UF membrane were used to separate and purify the Caulis sinomenii extract solution to remove the invalid ingredients, and the two kinds of membranes were cleaned with 1% sodium hypochlorite solution and pure water, respectively, to keep satisfactory membrane fluxes. The study provided an environment-friendly alternative for the separation and purification of alkaloids in natural products, which has a good prospect for the industrial


: In this study, the effect of fractional derivatives, whose application area is increasing day by day, on curves is investigated. As it is known, there are not many studies on a geometric interpretation of fractional calculus. When examining the effect of fractional analysis on a curve, the Caputo fractional analysis that fits the algebraic structure of differential geometry is used. This is because the Caputo fractional derivative of the constant function is zero. This is an important advantage and allows a variety of fractional physical problems to be based on a geometric basis. This effect is examined with the help of examples consistent with the theory and visualized for different values of the Caputo fractional analysis. The difference of this study from others is the use of Caputo fractional derivatives and integrals in calculations. Fractional calculus has applications in many fields such as physics, engineering, mathematical biology, fluid mechanics, signal processing, etc. Fractional derivatives and integrals have become extremely important as they give more numerical results than classical solutions in solving various problems in many fields. In addition, many problems that cannot be answered by classical analysis have been solved by Caputo fractional analysis. In this context, the curvatures of a curve are calculated by Caputo fractional analysis and obtained differently from the classical result. It is aimed to characterize the curve more accurately with the numerically more accurate calculation of the curvatures.


Bill Gates said "Microsoft products are generally bug free," while in practice operating systems and service programs by vendors like Microsoft as well as open-source communities contain numerous bugs, which lead to dangerous security vulnerabilities. Innovative ideas and apparatus for hardening software will be presented. Novel nonblocking concurrent monitoring is proposed and implemented to detect attacks with high efficiency. Upon detection, diagnosis learns the attacking behaviors automatically. Finally, the software itself (i.e., no manual effort is involved) generates and applies precise patches instantly without changing software semantics. The end-to-end solution defeats dangerous attacks including Heartbleed with low overhead (< 7%).


Confronting upheavals in the global economy, the prominence of global political conflicts, the global risks created by environmental damage, and the new connections forged through global media and migrations, many recognize the need for renewal of social solidarity. How do we imagine cohabitation and ideally cooperation on large-scales, at long distances, and with deep differences? This question is pressed on us by our embeddedness in impersonal systems like the global economy, the prominence of global political conflicts, the global risks created by environmental damage, and the connections forged through global media and migrations. This project addresses the basic question of how that solidarity can be achieved – and in what ways it is limited or resisted – on scales larger than directly interpersonal relations yet more specific than abstract universal categories like the human.
The focus of the project is on the problem of being "good strangers", that is, of finding appropriate ways to cohabit and cooperate that are not entirely dependent on interpersonal relationships (as in friendship, family, and local community) or common culture (whether national, religious, or other). It is a problem Durkheim made famous, though his account of functional integration within the nation-state did not fully resolve it. Appeals to abstract, universal principles such as human rights do not by themselves provide an adequate framework for understanding the effort to forge relationships across lines of difference. An adequate cosmopolitan perspective cannot be based simply on the notion of equivalence among human individuals, nor on universal application of concrete norms. It must take deeper account of difference and of solidarities between the scales of families and friends and humanity as a whole. Both sociological analysis and normative improvements depend on grasping the nature of connections and transformations at these intermediate scales. Solidarities are multiple and overlapping: nations, religions, ethnicities, professions, and more. Connections are also created through media, markets, migration, social movements, life in neighborhoods, employment in giant corporations, shared reliance on natural resources like rivers, and shared exposure to environmental degradation. Analysis of the dynamics of connections, of what responsibilities follow from them, and of what makes them more peaceful and productive or conflictual and destructive is a vital complement to study of immediately interpersonal solidarities on the one hand and universal norms on the other. Connections do not all follow the logic of "nesting" or matching populations to territories – as local, national, and global scales stereotypically do. Many are cross-cutting, as for example humanitarian interventions, religious missions, migrations, and business ventures are all organized across the lines of more stable, longer-term solidarities. Cities are not simply one intermediate scale, but also sites for dynamic relations among people in different cross-cutting solidarities. Conventional comparison of nation-states misses much; it is crucial also to attend to circulations, more or less porous edges as well as borders, linkages, mutual influences, and contexts. Above all, both sociological and normative analysis must focus on transformations not assumed steady states. Relations across lines of difference are never just translations of cultural content; they always open the possibility of transformation of the participants. The making and remaking of connections changes the connected parties (whether these are individuals or formal organizations or solidarities at various scales).
Craig CALHOUN is Professor of the Social Sciences at New York University and is the founding director of NYU's Institute for Public Knowledge. He has also served as the president of the Social Science Research Council (SSRC) since 1999.
As an individual scholar, he has written on culture and communication, technology and social change, social theory and politics, and on the social sciences themselves. His most recent books include Nations Matter: Culture, History, and the Cosmopolitan Dream (Routledge, 2007) and Cosmopolitanism and Belonging (Routledge, forthcoming 2009), and the University of Chicago Press is publishing a collection of his historical essays, entitled The Roots of Radicalism. Calhoun recently edited two noteworthy collections: Sociology in America (Chicago, 2007) and Lessons of Empire: Imperial Histories and American Power, with F. Cooper and K. Moore (New Press, 2006).
Throughout his career, he has been involved in projects bringing social science to bear on issues of public concern. These have ranged from consulting on rural education and development in North Carolina, to advising the Constitutional Commission of Eritrea, to helping develop communications infrastructure in Sudan. Most famously, he provided a detailed eyewitness account—and award-winning sociological analysis—of the student revolt in Tiananmen Square, in his most popular work to date, Neither Gods nor Emperors: Students and the Struggle for Democracy in China (California, 1994).
Craig Calhoun received his doctorate from Oxford University. He taught at the University of North Carolina at Chapel Hill for 19 years, where he also served as dean of the Graduate School and director of the University Center for International Studies. He has been a visiting professor in China, Eritrea, France, Norway, and Sudan.


In Yongning Na, there exists a bewildering diversity of tone patterns on numeral-plus-classifier phrases. A systematic investigation brings out no less than nine sets of classifiers on the basis of their tonal behaviour in association with numerals. These phenomena are analyzed here as part of the irregular tonal morphology found in Yongning Na. The present work represents a contribution towards a complete description of the rich tonal morphology of this language.


A visible light-driven cadmium-free ZnS/rGO/CuS porous photocatalyst heterojunction was synthesized by simple hydrothermal and cation exchange methods using a zeolitic imidazolate framework (ZIF-8) as the template and Zn precursor. Due to the ZIF-8 templated high porous microstructure and/or the high carrier conductivity of the graphene (rGO), ZnS/CuS and ZnS/rGO/CuS heterojunctions exhibited a photocatalytic H2-production activity 9 and 13 times larger than that of the counterpoint heterojunction derived from the inorganic precursors under visible light irradiation, respectively. This work will provide an insight into the design and synthesis of ternary composite photocatalyts with high porosity and efficient charge separation and transfer.


Centrifuges serve as essential instruments in modern experimental sciences, facilitating a wide range of routine sample processing tasks that necessitate material sedimentation. However, the study for real time observation of the dynamical process during centrifugation has remained elusive. In this study, we developed an innovative Lab_in_a_Tube imaging spectrophotometer that incorporates capabilities of real time image analysis and programmable interruption. This portable LIAT device costs less than 30 US dollars. Based on our knowledge, it is the first Wi Fi camera built_in in common lab centrifuges with active closed_loop control. We tested our LIAT imaging spectrophotometer with solute solvent interaction investigation obtained from lab centrifuges with quantitative data plotting in a real time manner. Single re circulating flow was real time observed, forming the ring shaped pattern during centrifugation. To the best of our knowledge, this is the very first observation of similar phenomena. We developed theoretical simulations for the single particle in a rotating reference frame, which correlated well with experimental results. We also demonstrated the first demonstration to visualize the blood sedimentation process in clinical lab centrifuges. This remarkable cost effectiveness opens up exciting opportunities for centrifugation microbiology research and paves the way for the creation of a network of computational imaging spectrometers at an affordable price for large scale and continuous monitoring of centrifugal processes in general.


Recently, long noncoding RNAs (lncRNAs) have been shown to have important regulatory roles in human cancer biology. By utilizing publicly available lncRNAs expression profiling data and integrating analyses, we screened out LINC00668, whose expression is significantly increased and correlated with outcomes in gastric cancer (GC). Further experiments revealed that LINC00668 knockdown significantly repressed proliferation, both in vitro and in vivo. Mechanistic investigations showed that LINC00668 was a direct transcriptional target of E2F transcription factor 1 (E2F1). We further demonstrated that LINC00668 was associated with PRC2 and that this association was required for epigenetic repression of cyclin-dependent protein kinase inhibitors (CKIs), including p15, p16, p21, p27 and p57, thus contributing to the regulation of the gastric cancer cell cycle. Our results suggest that E2F1-activated LINC00668, as a cell cycle regulator, enriches the mechanistic link between lncRNA and the E2F1-mediated cell cycle regulation pathway and may serve as a candidate prognostic biomarker and target for new therapies in human gastric cancer.


The Common Lisp Object System (CLOS) has received some praise and some criticism, both deserved. One of the most controversial features of standard CLOS is its linearly-ordered "class precedence list", which is used to linearly order the execution of its "combination" methods. In addition to the problems already known regarding the linear ordering of superclasses, we show that the standard CLOS class precedence ordering produces gratuitously complex and non-intuitive behavior. We then show that a slight modification of the standard ordering rules produces a linear ordering which can achieve most of the goals of CLOS more efficiently, and without impacting most programs. We describe a subset of CLOS called Static CLOS which preserves much of the praise due CLOS, while eliminating some of the criticism. Static CLOS is tuned for delivery of debugged code, rather than for prototype development. This "delivery" CLOS determines as many methods as possible at compile-time using "type inference" techniques. While these techniques generally result in faster-executing code, the space requirements can grow quite large. We argue that this space explosion can be partially ameliorated through the use of our modified class precedence ordering.


This book employs the tools of philosophical reflection to examine a number of ethical issues that arise from the endeavours of ethnic minorities to get greater space in the Kenyan polity, or even to exit the Kenyan state to form new states or to join other states that would better serve their interests. It contends that along with the rights of the individual citizen exalted in liberal democratic societies such as those in Western Europe and North America, Kenya's constitution must adequately recognise ethnic rights if the country is to effectively address the rampant discontent among members of her numerous ethnic minorities who feel perpetually marginalised in the country's economic, social and political life. If you are new to Kenyan politics, read this book and acquaint yourself with the intriguing yet agonising realities of a post-colonial cosmopolitan African society struggling to be at peace with itself. If you are a seasoned scholar of Kenyan politics, read this book and get an opportunity to reflect on the philosophical issues that are so often ignored by empirical studies of Kenyan politics.


The structural and thermodynamic properties of tethered polymer chains in the good solvent regime are studied using the single-chain mean-field theory. The mushroom to brush transition is found to be broad. For surface coverages below the brush regime, i.e., mushroom regime and crossover region, the relevant length scale of the layers is found to be the bulk radius of gyration of the chains, R g , while in the brush regime the relevant length scale is the distance between tethering points as assumed in the analytical approaches. The onset of the brush regime corresponds to the beginning of the overlap between the chains as measured by the distance-dependent lateral radius of gyration of the chains. The predictions of the theory for the height of the polymer layer and the lateral pressures as a function of the surface coverage are compared with recent experimental observations of Kent and co-workers. Excellent agreement is found for the height of the brush for all surface coverages. The experimental lateral pressures multiplied by the square of the bulk radius of gyration are found to be a universal function of the reduced surface coverage, * =πR g 2 . The predictions of the theory are in good agreement with the experimental measurements up to values of the reduced surface coverages * ∼8. For higher reduced surface coverages the theoretical results deviate from the scaling found experimentally. This deviation is consistent with the fact that these surface coverages correspond to the brush regime. The theoretical lateral pressure is found to be better described as a universal function of * ∼8 from low to relatively high surface coverages. From the analysis of the average conformational properties of the chains, it is argued that the behavior of the measured lateral pressures at high reduced surface coverages may be due to nonequilibrium effects. From the comparisons between the theory and the experiments it is found that most of the measurements correspond to the crossover region between the mushroom and the brush regimes. This explains the scaling found for most experimental properties


Erythrocyte transketolase has been measured in normal controls and non-alcoholic patients not at risk from nutritional deficiency and without signs of brain damage. The enzyme activity declines steadily with age over a range from 18 to 90 years with a statistically significant fall of 25% over this period. Since this decline is apparent whether or not thiamin diphosphate is added in vitro to activate the apoenzyme, the activation ratios are independent of the age effect. The decline is seen in both sexes in patients and normal subjects. It is concluded that the reliability of the specific transketolase activity as an indicator of marginal thiamin deficiency will be improved if the results are expressed as a percentage of the mean normal value corrected for age with values less than 60% of the age adjusted mean taken to indicate possible deficiency.


The third in a series of AACR conferences, entitled "Tumor Immunology: Basic and Clinical Advances," was held in Miami Beach, Florida from November 30 to December 3, 2010. The overall objective of this meeting was to discuss rapid developments in the understanding of basic principles of antitumor immunity and strategies for increasing the success rate of cancer immunotherapy. The key findings that emerged from the meeting included (i) that integrated approaches are required for the development of effective cancer immunotherapies and (ii) attention should be on multiple cellular and molecular components and their broader networks rather than on a single pathway or cell type.


Structural reforms are often designed to change the prices of key goods and services. Since the overall intention of such reforms is the reduction of poverty, it is important to understand how the resulting price changes affect the poor. However, organizations seeking to provide timely advice to policymakers in developing countries often do not have the data and resources needed to undertake the most sophisticated approaches to such analysis. McCulloch outlines a simple methodology based on the analysis of household survey data to estimate the first-order impact of a variety of structural reforms. He also elaborates on the ways in which this methodology may be extended in a flexible way to account for particular features of a country in question. Finally, he outlines the direction of some extensions on the approach to tackle dynamics, risk, and qualitative poverty analysis.


SUMMARYTo determine whether cold could activate the kallikrein-kinin system in vivo as it does in vitro, the circulating systemic concentrations of bradykinin were serially measured in 10 children with congenital diseases of the heart undergoing corrective cardiac surgery. Bradykinin was measured by radioimmunoassay in blood samples obtained before, during and after profound hypothermia (to 18°C) and cardiopulmonary bypass. The circulating concentrations of bradykinin increased significantly as body temperature decreased during surface cooling. The increase in circulating bradykinin was associated with a decrease in the circulating level of bradykininogen, the precursor of bradykinin. With the onset of cardiopulmonary bypass and hence, removal of the lung and pulmonary converting enzyme from the circulation, there was a further rise in the already elevated concentrations of bradykinin. This is the first in vivo demonstration that hypothermia leads to an increase in the circulating concentrations of bradykinin.


Chronic type B aortic dissection complicated by repetitive transient spinal cord ischaemia is rare. Reduced blood flow in the segmental arteries supplying the radicular arteries in the false lumen is the main cause of this pathology. Individual variations in spinal cord circulation are difficult to identify; therefore, the mechanisms of spinal cord ischaemia are poorly understood. We encountered a patient with chronic type B aortic dissection experiencing repetitive spinal cord ischaemia that finally led to spinal cord infarction. The patient recovered, except for mild monoparesis of the right leg. With the growth of the dissected aorta, we planned for surgical treatment to restore the blood supply in the spinal cord. The patient underwent thoraco-abdominal aortic repair using deep hypothermia, and favourable neurological results were achieved.


Following The Emergent Organization (2000) and The Situated Organization (2011), James R. Taylor and Elizabeth Van Every pursue their inquiry into the communicative constitution of organization in their latest book, entitled When Organization Fails: Why Authority Matters (hereafter, Why Authority Matters). As the third part of what can be thought of as a trilogy, this book extends the communicational framework developed by the authors in their previous books to study organization and organizing. This framework can be summarized by the following thesis: organization essentially consists of interconnected processes of communication; this is defined as the recursive articulation of conversations and texts. Hence, for Taylor and Van Every, organization emerges in communication as described in text – organization becomes an object toward which actors coorient their actions – and realized in conversation – organization is enacted by actors through situated interaction.


Magnetoelastic sensors for the detection of low-frequency and low-amplitude magnetic fields are in the focus of research since more than 30 years. In order to minimize the limit of detection (LOD) of such sensor systems, it is of high importance to understand and to be able to quantify the relevant noise sources. In this contribution, cantilever-type electromechanic and magnetoelastic resonators, respectively, are comprehensively investigated and mathematically described not only with regard to their phase sensitivity but especially to the extent of the sensor-intrinsic phase noise. Both measurements and calculations reveal that the fundamental LOD is limited by additive phase noise due to thermal-mechanical noise of the resonator, i.e. by thermally induced random vibrations of the cantilever, and by thermal-electrical noise of the piezoelectric material. However, due to losses in the magnetic material parametric flicker phase noise arises, limiting the overall performance. In particular it is shown that the LOD is virtually independent of the magnetic sensitivity but is solely determined by the magnetic losses. Instead of the sensitivity, the magnetic losses, represented by the material's effective complex permeability, should be considered as the most important parameter for the further improvement of such sensors in the future. This implication is not only valid for magnetoelastic cantilevers but also applies to any type of magnetoelastic resonator.


Dashboards are used in many different situations where it is necessary to be able to display information on a single screen, in a way so that the information can be monitored at a glance. This thesis explore the possibility of using a dashboard for the new graphical user interface of PinDown, an automatic debugging tool developed by Verifyter. The dashboard will be used to monitor projects from a single view. The thesis investigate the current implementation of the interface in terms of usability as a reference point for what needs to be improved with the new design. We present three different frameworks for web application development, Ruby on Rails, Django and Play, and compare them against each other with respect to backwards compatibility, ability to obfuscate, compile to WAR and server-side thread safety. We evaluated the dashboard design through user tests of the developed proof of concept. The result of this thesis was a prototype of the new graphical user interface which can be further built upon. The prototype was designed according to reliable design principles and the underlying architecture was carefully chosen, to make a robust basis for further development. For back end development we concluded that any of the mentioned frameworks could be used. The decision to use Play framework was based on our own experience with the Java programming language and the current implementation being written in Java. To visualize data in graphs we used NVD3, a charting library written in D3.js and to make the application responsive we used Bootstrap, a front end framework that makes the design respond to resize and different screen types. Our conclusion is that the design met Verifyter's needs and that the dashboard should improve the usability of PinDown. The evaluation did not lead to any redesign but we found a few usability issues that were corrected. (Less)


This presentation consists of two parts. The first part gives a brief introduction of the Science & Technology Facilities Council of the UK, including its programmes and facilities with a focus on the challenging technologies needed for world-class scientific research. The second part is about the Phase-I Upgrade of the Level-1Trigger system of the ATLAS experiment at CERN. Rutherford Appleton Lab played a critical role in the original ATLAS Level-1 trigger system design, which has been running successfully since 2009 and led to the discovery of Higgs-boson in 2012. Starting in 2021, the LHC luminosity will double, which will increase the pileup rate. However, the ATLAS front-end detector electronics will remain largely unchanged. Hence the total ATLAS Level-1 Trigger rate will still be limited by the readout bandwidth of the front-end electronics to 100 KHz or less. Moreover, the Level-1 Trigger must retain sensitivity to the physics electroweak processes and stay within the current ATLAS Level-1 latency envelope of 2.5µs. To meet these new challenges, the Phase-I Upgrade to the ATLAS Level-1 Trigger system is needed. The focus of the second half of this presentation is on the overall architecture of the Phase-I Upgrade, the trigger algorithms and performance, the prototype design and test results.


A cathode spot model is used to analyze the instability phenomena of a vacuum arc. The current below which no real solution exists is believed to be an unstable region. When the current decreases below 19 A, the electrons returning to the sheath region from the plasma region were found to dominate over the positive ions and, thus, the cathode electric field has an imaginary solution. An electrostatic probe was used to confirm these findings, and the analytical results were similar to measurement results. The present cathode spot model may be valid for volatile materials.


Psychological symptoms were found to be associated with a number of cognitive appraisal and demographic variables but predicted primarily by perceived lack of control among information seekers in the aftermath of the Three Mile Island accident. Cognitive appraisal variables were found to be interrelated in a way which suggests that appraisal of control and faith in experts mediate between perceived environmental threat and psychological symptoms among information seekers in the aftermath of technological disaster. Demographic variables such as education and evacuation status are viewed as mediators between environmental circumstances and cognitive appraisals.


The results of 5 subjects in a deadline-type laboratory task, simulating a hazardous activity with a trade-off between safety and efficiency, showed two basic categories of accident potential. The first one stems from the very normal behavior in which the subjects maintain too small margins of safety and incur an accident in the case of certain coincidences. The second is based on major errors in decision-making or performance resulting in deviant behavior which either is a sufficient cause of an accident or much increases the probability of an accident when the system does not provide sufficient margins of safety.


The electronic phase diagram of the weak spin-orbit Mott insulator (Sr(1-x)La(x))(3)Ir(2)O(7) is determined via an exhaustive experimental study. Upon doping electrons via La substitution, an immediate collapse in resistivity occurs along with a narrow regime of nanoscale phase separation comprised of antiferromagnetic, insulating regions and paramagnetic, metallic puddles persisting until x≈0.04. Continued electron doping results in an abrupt, first-order phase boundary where the Néel state is suppressed and a homogenous, correlated, metallic state appears with an enhanced spin susceptibility and local moments. As the metallic state is stabilized, a weak structural distortion develops and suggests a competing instability with the parent spin-orbit Mott state.


This chapter critically assesses whether indirect forms of human rights implementation, which rely on the political process rather than judicial enforcement, enable the Australian Government to fulfil its international obligations to ensure that all Australians enjoy all their human rights. This assessment focuses on the right to enjoy an adequate standard of living, which is included in the International Covenant on Economic, Social and Cultural Rights 1966, which is binding on the Australian Government. The effectiveness of the indirect measures used to implement some incidents of the right to an adequate standard of living are examined, using the national Supported Accommodation Assistance Program (SAAP) as a case study. The study reveals that the main problems with this form of implementation are the lack of independent accountability mechanisms, and the related absence of effective remedies in the event of a violation. In conclusion, the chapter suggests that some measure of legal accountability (direct implementation) is indispensable to fully comply with international obligations, and that this may not necessarily be incompatible with Australia's democratic traditions.


***The Corrosion diagnosis and the corrosion mechanism investigations of carbon steel covered with mill scale in distilled water and aqueous solution containing various component (Cl-, SO42-, HCO3-, SiO2) were performed by using ENA. It has been clarified that the corrosion patterns could be discriminated by the measurements of potential time series and that the effects of the water quality factor on the corrosion could be discussed. Bicarbonate ions whose concentration is less than 10ppm accelerate the corrosion of carbon steel covered with mill scale. Besides, the bicarbonate ions whose concentration is 100ppm stabilize the mill scale. In neutral solution, the dissolved silica accelerates the anode reaction of carbon steel. Contrary to this in alkaline solution, the dissolved silica gives the corrosion resistance to the carbon steel with covered with mill scale.


Fishing has affected North Sea ground fish species diversity. De. ning Marine Protected Areas (MPAs) to address this will rely on ground fish surveys. Species-specific catch efficiencies vary between trawl gears, and apparent species diversity distributions are influenced by the type of gear used in each survey. It may be that no single survey depicts actual diversity distributions. Two MPA scenarios designed to protect ground fish species diversity are described, the first based on unadjusted International Bottom Trawl Survey data and the second based on the same data adjusted to take account of catchability. Spatial overlap between these scenarios is low. Assuming that the adjusted data best describe the actual species diversity distribution, the level of diversity safeguarded by MPAs, based on unadjusted data, is determined. A fishing effort redistribution model is used to estimate the increase in fishing activity that is likely to occur in MPAs that take catchability into account, if closed areas based solely on the unadjusted ground fish data were implemented. Our results highlight the need to take survey-gear catchability into account when designating MPAs to address fish-species diversity issues


BACKGROUND Noise-induced hearing loss (NIHL) is the second most common acquired hearing loss following presbycusis. Exposure to recreational noise and minimal use of hearing protection increase the prevalence of NIHL in young females. NIHL is irreversible. Identifying minor hearing pathologies before they progress to hearing problems that affect daily life is crucial. AIM To compare the advantages and disadvantages of extended high frequency (EHF) and otoacoustic emission and determine an indicator of hearing pathologies at the early sub-clinical stage. METHODS This cross-sectional study was implemented in West China Hospital of Sichuan University from May to September 2019. A total of 86 participants, aged 18-22 years, were recruited to establish normative thresholds for EHF. Another 159 adults, aged 18-25 years with normal hearing (0.25-8 kHz ≤ 25 dBHL), were allocated to low noise and noise exposure groups. Distortion otoacoustic emission (DPOAE), transient evoked otoacoustic emissions (TEOAE), and EHF were assessed in the two groups to determine the superior technique for detecting early-stage noise-induced pathologies. The chi-square test was used to assess the noise and low noise exposure groups with respect to extended high-frequency audiometry (EHFA), DPOAE, and TEOAE. P ≤ 0.05 was considered statistically significant. RESULTS A total of 86 participants (66 females and 20 males) aged between 18 and 22 (average: 20.58 ± 1.13) years were recruited to establish normative thresholds for EHF. The normative thresholds for 9, 10, 11.2, 12.5, 14, 16, 18, and 20 kHz were 15, 10, 20, 15, 15, 20, 28, and 0 dBHL, respectively. A total of 201 participants were recruited and examined for eligibility. Among them, 159 adults aged between 18 and 25 years were eligible in this study. No statistical difference was detected between the noise exposure and the low noise exposure groups using EHFA, DPOAE, and TEOAE (P > 0.05) except in the right ear at 4 kHz using TEOAE (abnormal rate 20.4% vs 5.2%, respectively; P = 0.05). CONCLUSION These results showed TEOAE as the earliest indicator of minor pathology compared to DPOAE and EHFA. However, a multicenter controlled study or prospective study is essential to verify these results.


Researchers and policymakers have long called for a collaborative governance process for climate adaptation and flood resilience. However, this is usually challenging when urban planning is supposed to be integrated with water management. Using the Chinese city of Guangzhou as a case study, this study explores the long-term disadvantaged conditions of urban planning in flood governance and how this situation is shaped. The findings show that, in comparison to the increasingly dominant position of water management in flood affairs, the urban planning system has had weak powers, limited legitimate opportunities, and insufficient fiscal incentives from the 2000s to the late 2010s. Those conditions have been shaped by organizational structures, institutional rules, and financial allocation in urban governance, whose changes did not bring benefits to urban planning. The emergence of the Sponge City Program in China in 2017 and its implementation at the municipal level is deemed to be a new start for urban planning, considering the encouragement of nature-based solutions and regulatory tools in land use for flood resilience. Even so, the future of this program is still full of challenges and more efforts are needed.


serious delay in eventual diagnosis, resulting from misplaced parental confidence. One-thirdof the true positives were suspected of having hearingimpairmentsbefore the screening was performed and screening was used by theparentsas confirmation. These figures make the value of screening to date ratherquestionable. The questions to be determined,then, are: (i) does screening result in more cases being diagnosed by a given age than would occur without screening: (ii) are those cases found by screening unsuspectedor suspected cases: (iii) does the rate and age at detection by screening outweigh the rate and increaseddetectionage of the false negatives: (iv) what rate of detectionmakes aprogrammeeconomically viable in view of time, cost, andallocationof funds and resources. The Victorian experience will be followed with great interest in these regards.


In this paper we describe the steps taken to solve electrothermal problems in distributed configurations. For that purpose, we computed the 3D temperature distribution in a dry type transformer by solving the Poisson equation with source terms specific to the topology under scope, that is, heat generation by Joule losses and eddy currents, as well as natural cooling on the outside of the metal casing. Our approach is based on the assumption that heat transfer in the electrical device is predominantly diffusion. The solver used for this problem is the well-know BICCG (block incomplete Choleski conjugate gradient).


The present study was undertaken in Maroorpatti village in Namakkal district of Tamlnadu. From the results of the livelihood analysis conducted for the three different categories of wealth ranking , it may be pointed out that with respect to the size of land holdings the rich farmer had double the size of the medium and as such large as 10 times that the poor farmer. The rich farmer had an incomparably large number of cattle with respect to his counterparts. While the rich farmer received monthly income from livestock, the medium farmer, who was thus classified solely by his agricultural land holdings, always expected his agricultural field to boost his monthly income. Furthermore, from the expenditure pattern observed, the rich farmers were inclined to save nearly 35% of their monthly income, while the poor farmers were always in need of 25% loan to meet their monthly needs. As a consequence, the crises analysis indicated that the poor farmer as well as the medium farmer usually takes a loan of 40% towards meeting any calamities faced in their agricultural and livestock sectors.


The paper presents a study on design, analysis and implementation of a sub-fractional slot winding brushless dc motor with unequal tooth widths which is intended to use for light electric vehicle propulsion. Unconventional motor structures are gaining attention because of demands for electric vehicle technology. The main object is to design a BLDC motor having a larger value direct-axis phase inductance which is enabling high performance field weakening operation. For this reason, a subfractional slot concentrated winding structure with unequal tooth widths is chosen. The design phase is including the motivation and the computer aided design works. A software package based on configurator approach is used to determine the motor parameters in a broad sense. Then the motor is modeled in a FEA package for detailed analysis. The designed motor is manufactured precisely and an experimental study is held to verify the design work. The comparison of calculated and experimental results shows that most of the motor parameters can be obtained with a good accuracy.


BACKGROUND
There is limited information on the risk of hospital-acquired COVID-19 among high-risk hospitalized patients after exposure to an infected patient or healthcare worker (HCW) in a non-outbreak setting.

METHODS
This study was conducted at a tertiary care cancer center in New York City from March 10, 2020, until February 28, 2021. In early April 2020, the study institution implemented universal SARS-CoV-2 testing at admission and retesting every three days through the hospital stay. Contact tracing records were reviewed for all exposures to SARS-CoV-2 positive patients and HCWs.

RESULTS
From March 10, 2020, to February 28, 2021, 11,348 unique patients who were SARS-CoV-2 PCR negative at the time of admission underwent 31,662 post-admission tests during their hospitalization, and 112 tested positive (0.98%). Among these, 49 patients housed in semi-private rooms during admission resulted in 74 close contacts and 14 secondary infections within 14 days, for an overall attack rate of 18.9%. Among those exposed to a roommate undergoing an aerosol-generating procedure (AGP), the attack rate was 35.7%. WGS corroborated transmission in 6/8 evaluated pairs. In addition, three transmission events occurred in 214 patients with significant exposure to 105 COVID-19 positive healthcare workers (1.4%).

CONCLUSION
The overall risk of hospital-acquired COVID-19 is low for hospitalized cancer patients, even during periods of high community prevalence. However, shared occupancy with an unrecognized case is associated with a high secondary attack rate in exposed roommates.


This paper questions if the civil society organizations (in portuguese, OSCs) can and do accomplish their role of exercising a representative function in times of crisis of the political parties. In order to do so, it examines recent practices of representation in Brazil and in Argentina, two countries where political parties have gone through acute crises after decades of ambiguous evaluations regarding their partidary systems. In such moments, any substitution of parties for OSCs should be easily identifiable. Initially, the functions and the representative potential of OSCs are examined, using the political party model as reference. Then, it is shown from already published surveys and unpublished field research, in a comparison focused in how well the parties and OSCs have been carrying out their public and organizational functions in Brazil and in Argentina. The conclusion is that OSCs do not substitute parties as mechanisms of representation of citizens' values and interests - and do not even try to do that, except for a brief period, in the peak of the crisis in Argentina. In both countries, however, OSCs improve the quality of the citizens' representation.


Negative ion photoelectron spectra of Cu−n (n=1–10) are reported for the 0–2.4 eV region at an instrumental resolution of 10 meV. The cluster anions were prepared in a flowing afterglow ion source incorporating a cold cathode dc discharge. This very simple source provides a convenient, general method to prepare continuous beams of near‐thermal metal cluster ions at intensities (up to 10−11 A) sufficient for spectroscopic or chemical studies. Photoelectron spectra of the copper cluster anions yield measurements for vertical electron binding energies and adiabatic electron affinities as a function of cluster size. The overall trend observed is well described by the classical spherical drop electrostatic model. In addition, quantum effects are apparent in the higher electron affinities generally observed for clusters containing odd numbers of atoms. Excited electronic states in the photoelectron spectra show that the transition energy in the neutral molecule decreases rapidly with cluster size. Vibrational s...


Recent developments in urban storm drainage are reviewed starting with rainfall/runoff processes, followed by discussions of combined sewage, drainage impacts on receiving waters, impact mitigation, hydroinformatics, regulatory programs and conclusions. The most promising trends in this field include improvements in spatial definition of rainfall data, runoff modelling with a limited number of model parameters and recognition of modelling uncertainties, analytical statistical modelling of runoff quality, advances in the understanding and modelling of sewer sediment transport, the use of biomonitoring and modelling in assessing drainage impacts on receiving waters, further refinement of best management practices for stormwater management, development of new processes for treatment of stormwater, experience with vortex combined sewer overflow structures and their applications in combination with other treatment devices, real time control of sewer system operation, advances in hydroinformatics leading to improvements in the integrated management and modelling of drainage systems, interfacing of drainage models with geographic information systems, and improved regulation of drainage effluents.


The overcasting reinforcement process is a complex casting technique for creating lightweight aluminum components with additional strength from an aluminum matrix composite (AMC) insert. Empirical work to date has shown there are opportunities to further enhance the quality of adhesion between this AMC insert and cast aluminum. It is also evident that developing a predictive tool of bond quality will reduce the need for invasive measuring techniques.


This paper examines how multinational corporations (MNCs) protect their intellectual property (IP) when they conduct R&D in countries with weak IP rights (IPRs) protection. Findings from a small-scale survey and three case studies in China show that hierarchical segmentation of the R&D process can provide an effective way for IPR protection. Furthermore, a modular R&D structure adopted by many information technology companies can facilitate the hierarchical segmentation. Because R&D is becoming distributed across locations with varying levels of IPR protection, a center-peripheral R&D organizational structure is emerging within MNCs as R&D globalization proceeds.


Because business policy research has primarily been a series of
inductive generalizations of case studies; theories have been typically
ambiguous and untested, and have not progressed swiftly. Deductive
theorizing, by contrast, yields clear, often non-obvious conclusions
that can be debated effectively and generalized slowly; so realism of
current models can be sacrificed for progress towards realistic future
models. Deductive theorizing, with more attention to a game-theoretic
definition of equilibrium and to recent ideas from
economics, should be one new direction for policy research. Of
course, these deductive models will inevitably draw their inspiration
from the richness of careful observation and exhaustive checklist-making
that are the hallmarks of induction. Specific avenues for new
research are described, and the importance of teaching non-obvious
theories is defended.


Imagine you fly home from vacation with your one-and-a-half-year-old son who is traveling for free as a "lap child." In the airport parking lot, you put him into his forward-facing car seat, where he sits much more contentedly than he did in the rear-facing one that was mandatory until his first birthday. After he falls asleep on the way home, you transfer him to his crib without waking him, lowering the side rail so you can lift him in more easily. Many parts of this idyllic parenting picture are deemed unacceptably risky according to recent child safety proposals. While these proposals all aim to improve child safety, their possible impact is unclear because there has been little discussion of the absolute risk and risk reduction involved in each. And while precise figures are lacking, rough estimates indicate that the magnitudes are quite small. I will argue that this risk and benefit data raises important questions about the proposals, including whether parents might reasonably believe that the small absolute risk reduction offered by the proposed changes does not justify the attendant burdens. This possibility-termed the "prevention paradox" in other contexts-highlights ethical and theoretical challenges in this area of public health. Language: en


The present invention discloses a ball valve ball body surface spray-welding apparatus with a characteristic of uniform ball body surface spraying, wherein a temperature control box comprises an upper box body and a lower box body, the upper box body is provided with a spraying gun door, the upper box body covers on the lower box body, a cavity for placing a ball body is arranged inside the temperature control box, a core shaft having an elastic form penetrates through the hole of the ball body and is closely matched with the ball body, both ends of the core shaft bear against respectively through the front end chuck and the tail frame of a speed reducing box, the outer side of the spraying gun door is provided with a spraying gun, and the spraying gun is connected to a spraying gun swinging mechanism. According to the present invention, the structure is reasonable and the sprayed member is integrally pre-heated in the temperature control box, such that the thermal efficiency is high, the temperature is uniform, the binding compactness is high, and the binding surface stress is low; the sprayed member is integrally subjected to re-fusion in the temperature control box and all surfaces are completely subjected to metallurgical combining, such that the peeling-off is eliminated; the cooling is performed along with the box, the hardness of all surfaces is uniform, the processing efficiency is high, and the quality is good; and the working environment of the personnel is improved, and the labor intensity is reduced.


Optical amplification is demonstrated in waveguides of composite materials consisting of nanocrystals of Cr:forsterite or Cr:diopside embedded in a host polymer with a matching refractive index. Small-signal gains of 1dB / cm at lambda=1.23microm are reported.


The visually challenged are often alienated from mainstream society because of their disabilities. This problem is even more pronounced in developing countries which often do not have the resources necessary to integrate this people group into their communities or even help them to become independent. It should therefore be the aim of governments in developing countries to provide this vulnerable people group with access to assistive technologies at a low cost. This paper describes an ongoing project that aims to provide low-cost assistive technologies to the visually challenged in Barbados. As a part of this project a study was conducted on a sample of visually challenged members of the Barbados Association for the Blind and Deaf to determine their ICT skills, knowledge of Braille and their use of assistive technologies. An analysis of the results prompted the design and creation of a low-cost Braille device prototype. The cost of this prototype was about one-half that of a commercially available device and can be used without a screen reader. This device should help create equal opportunities for the visually challenged in Barbados and other developing countries. It should also allow the visually challenged to become more independent.


This study aimed to characterize the national and international scientific production focused on investigating the relationship between creativity and difficulties / learning disabilities. Nationally were consulted the SCIELO databases, PEPSIC, CAPES and BDTD and internationally the APA bases, ERIC, PubMed and Scopus without delimitation of time. The results indicated the existence of 57 international and five domestic productions. The analysis found that there were no significant statistical differences between the averages of the past three decades productions; the investigations have focused mainly on the specific reading disability/Dyslexia; use of quantitative methodology; and using the Torrance Test. Some classifications given to groups investigated in most studies do not denote clearly the origins of learning disabilities, whether they were or not resulting from the learning disorder. We conclude that further studies are needed on the subject, provided there is a better characterization of the investigated groups and classifications used.


Abstract:This article is the product of a collaboration between a scholar of West African cinema (Fofana) and a historian of northern Mali (Hall), who together offer an interpretation of the politics of Abderrahmane Sissako's film Timbuktu (2014). This film is about the Islamist jihadist occupation of the Malian town of Timbuktu in 2012–13, and it succeeds in demonstrating some of the ways that the jihadist project tried to reorganize the lives of people in northern Mali by using violence or its threat to force women and men to dress according to Salafi sartorial codes, preventing men and women from socializing together outside of their immediate families, and banning soccer and music. Sissako's style of filmmaking lingers on a number of scenes in which the jihadists reveal themselves to be alternately confused and hypocritical about the edicts that they enforce, but also deeply intolerant and uninformed about the sophisticated Muslim culture that has thrived in Timbuktu for centuries. Yet the violence depicted in the film is not all at the hands of the jihadists, and in fact the climax of the film is produced by a conflict between a fisherman and a herder. This article is a close reading of Timbuktu in an effort to unpack what appears to be an urgent call to action by one of Africa's finest filmmakers, but also to appreciate Sissako's film aesthetic while problematizing the shortcomings of his representation of an otherwise complicated history.


We exploited mechanical instability in shape memory polymer (SMP) membranes consisting of a hexagonal array of micron-sized circular holes and demonstrated dramatic color switching as a result of pattern transformation. When hot-pressed, the circular holes were deformed to an array of elliptical slits (with width of tens of nanometers), and further to a featureless surface with increasing applied strain, therefore, switching the membrane with diffraction color to a transparent film. The deformed pattern and the resulting color change can be fixed at room temperature, both of which could be recovered upon reheating. Using continuum mechanical analyses, we modeled the pattern transformation and recovery processes, including the deformation, the cooling step, and the complete recovery of the microstructure, which corroborated well with experimental observations. We find that the elastic energy is roughly two-orders of magnitude larger than the surface energy in our system, leading to autonomous recovery of the structural color upon reheating. Furthermore, we demonstrated two potential applications of the color switching in the SMP periodic membranes by (1) temporarily erasing a pre-fabricated "Penn" logo in the film via hot-pressing and (2) temporarily displaying a "Penn" logo by hot-pressing the film against a stamp. In both scenarios, the original color displays can be recovered.


Acoustic emission has previously been shown to be a useful technique in monitoring the state of wear in machine tools. The piezoelectric transducers conventionally used for acoustic emission detection are contacting devices with a limited bandwidth. Operationally, a non-contacting transducer of broader bandwidth would be preferred. The authors have accordingly developed a technique based on optical interferometry, using fibre optics, to produce a miniature and robust probe for detecting acoustic emission by measuring the small amplitude ( approximately 0.1 nm), high frequency (0.1-1 MHz) surface vibrations that it produces. They demonstrate the technique in measurements made probing both the workpiece and the rotating tool holder during face milling of mild steel.


The control mechanisms and instruments that eventually emerge in an organization are the result of a number of interrelated factors and processes. The design and construction of control instruments, the communication about them, the way in which the instruments are actually used, the processes of institutionalization that lead to the procedures and routines that are eventually entrenched in an organization, and processes of accounting change are just a few examples hereof. Of special interest to us is the behaviour of management accountants and controllers in the shaping of control. Accountants and controllers are not only of importance in the shaping of control mechanisms themselves. It is also in their best interest that the control mechanisms they design, develop and alter are actually used in a firm and function properly. Furthermore, it is part of a controller's core-business to handle the link between management information and accounting and control change. When studying the link between the behaviour of accountants and controllers and the institutional environment of a firm, it may be hypothesized that institutions both arise from and constrain social action, and that day-to-day operations involving institutions can be regarded as 'scripts'. Scripts describe observable, recurrent activities and patterns of interaction characteristic of a particular setting. Ultimately, scripts may become institutionalized in a firm. There is probably a greater tendency for the institutionalization of stereotypical behavioural patterns than for atypical patterns, since the latter are not common in an organization. Scripts may therefore be a useful tool to study how the institutionalization of accounting processes (which by definition involve stereotypical behaviour) comes about. In this paper, we describe the procedure and outcome of the collection of a group of so-called behavioural scripts that management accountants and controllers apply in various types of problem situations. Through the use of a variety of interview techniques we could find several patterns of action that controllers deem stereotypical in the shaping of control. We find that in order to get an idea how the institutionalization of accounting processes and instruments actually takes place in an organization - a topic that is as of yet (almost) unexplored in management accounting studies although it is attracting more and more attention, the discovery of scripts is an important first step.


When obtaining samples of phosphorus-containing lime-ammonium nitrate (LAN) the mass ratio ammonium nitrate (AN) : dolomite mineral (DM) : ordinary phosphate rock (OPR) varied from 100 : 0.5 : 0.5 to 100 : 25 : 25. The prilling method was used to granulate the nitrate-carbonate-phosphate melt. It is shown that the saltpeter melt activates carbonate and phosphate raw materials, that is, it converts the structure of P2O5, CaO and MgO, which is not assimilated in it, into a form that is assimilable for plants. The additives (DM, OPR) significantly reduce caking, porosity and absorption in relation to liquid fuel and increase the strength of fertilizer granules.


Inherited abnormalities of renal tubular transport processes encompass a heterogeneous set of disorders due to single gene defects. Elucidating the molecular basis for these generally rare disorders has provided important insights into disease pathogenesis as well as the complexities of normal renal transport physiology. This review focuses on the clinical features and recent molecular advances in cystinuria, X-linked hypophosphatemic rickets, and the Bartter-Gittelman spectrum of disorders. Also addressed are disorders of calcium homeostasis resulting from loss-of-function and gain-of-function mutations of the extracellular calcium-sensing receptor, as well as the single gene defects that cause distal renal tubular acidosis.


In China, crop structure adjustment policy has brought great change of different breed's planting area in different years. Government managers of agricultural industry need timely crop structure information to monitor the performance of the crop structure adjustment policy. The objective of this research was to evaluate the synergistic effects of multitemporal RADAR SAT synthetic aperture radar (SAR) and Land sat ETM+ data for extracting agricultural crops structure using an object-oriented classification approach. This paper instructs and analyses the crop structure near the Kaifeng city area in 2002. Four crop types were extracted: corn, soybean, cotton, and peanut. With the object-oriented classification approach, the overall accuracy of crop structure extracting from two-date F5 mode's SAR data (mid- to last-season) and two-date Land sat ETM+ is over 90%


In this paper, we propose a novel cellular optical wireless communications (COWC) system with four diffused cells. A dynamic handover scheme is proposed to make the link more flexible by the way of adaptive channel allocation in different environments. The simulation results show that the proposed algorithm offers almost five times of the maximum dynamic transmission bandwidth and energy efficiency compared to the worst scenarios when all base stations (BS)s are active.


Aquacobalamin reductase (NADPH), which catalyzes the reduction of aquacobalamin to cob(II)alamin in the synthesis of cobalamin coenzymes, has already been purified from mitochondria of Euglena gracilis and partly characterized. Here, the enzyme was further characterized to clarify its enzymatic properties. The enzyme reduced 2 mol of aquacobalamin per mole of NADPH and had NADPH diaphorase-like activity. The 16 amino acid residues at the NH2-terminal of the enzyme were identical with those of the NADPH diaphorase domain of pyruvate: NADP+ oxidoreductase, which is involved in Euglena wax ester fermentation. Peptide mapping of the aquacobalamin reductase showed that elution during C-18 reversed-phase high-performance liquid chromatography was identical to that of the NADPH diaphorase domain. Immunoblotting indicated that the Euglena aquacobalamin reductase had a higher molecular weight (166,000) in the intact mitochondria than the purified enzyme (65,000), and that the molecular weights of the native and purified enzyme were identical with those of the subunit and the NADPH diaphorase domain, respectively. These results showed that the aquacobalamin reductase isolated earlier was the NADPH diaphorase domain, cleaved by trypsin during preparation of the mitochondrial homogenate from the native enzyme. Purified pyruvate:NADP+ oxidoreductase also had the activity of aquacobalamin reductase, which suggests that the enzyme in Euglena mitochondria has more than one function in the synthesis of cobalamin co-enzymes.


Ischiorectal abscess accounts for one third of anorectal infections.Ischiorectal abscess spreading into the anterior abdominal wall and forming extensive abscesses is rarely encountered. We present a 52 year old diabetic patient who presented initially with perianal abscess. After a week he presented with abdominal wall cellulitis which soon progressed to an abscess which involved the entire abdominal wall circumferentially. Imaging did not reveal any communication into the peritoneal cavity. Multiple stab incisions were made in the abdominal wall and pus drained and the patient recovered.


The independence of judges as a criterion for assessing the effectiveness of judges in the conditions of reforming the judicial system of Ukraine is considered in the article. It is established that the principle of independence of judges from any interference in the process of adjudication is enshrined in international and Ukrainian normative legal acts,. The principle of independence is multifaceted and involves the adoption of various means for its implementation. It is established that the formation of an adequate level of independence of judges is important for sending fair proceedings and creating the conditions for citizens to restore confidence in the judicial system. After all, the Ukrainian courts generally maintain a negative balance of trust and mistrust in society: 14% of the population trust the courts while 75% do not trust (balance-61%). That is why it is important for the state to take measures that could simultaneously create the desire of judges to act independently, to develop mechanisms and guarantees for such independence, as well as to adjust the level of confidence in the judicial system in the minds of citizens. It is concluded that the existence of real but not declarative independence of the court is a litmus test for effective reform of the judicial system in Ukraine. Therefore, the practical maintenance of the independence of judges should be a priority for judicial reform.


The specific action of the crystalline protease obtained from Ps. myxogenes sp., was examined from its action on various proteins, determination of the N-terminal residues of the enzymatically degraded gelatin — which was most readily digested by the enzyme — and comparison with other proteinases, such as trypsin, papain and pepsin. It was shown that the enzyme might be classified as a collagenase and the mode of digestion of gelatin had a more close resemblance to papain than trypsin or pepsin.


We measured the Re/Os (185Re/188Os) and 187Os/188Os ratios from nanoparticles (NPs) using a multiple collector-inductively coupled plasma-mass spectrometer equipped with high-time resolution ion counters (HTR-MC-ICP-MS). Using the HTR-MC-ICP-MS system developed in this study, the simultaneous data acquisition of four isotopes was possible with a time resolution of up to 10 μs. This permits the quantitative analysis of four isotopes to be carried out from transient signals (e.g., <0.6 ms) emanating from the NPs. Iridium–Osmium NPs were produced from a naturally occurring Ir–Os alloy (ruthenosmiridium from Hokkaido, Japan; osmiridium from British Columbia, Canada; iridosmine from the Urals region of Russia) through a laser ablation technique, and the resulting nanoparticles were collected by bubbling water through a suspension. The 187Os/188Os ratios for individual NPs varied significantly, mainly due to the counting statistics of the 187Os and 188Os signals. Despite the large variation in the measured ratios, the resulting 187Os/188Os ratios for three Ir–Os bearing minerals, were 0.121±0.013 for Hokkaido, 0.110±0.012 for British Columbia, and 0.122±0.020 for the Urals, and these values were in agreement with the ratios obtained by the conventional laser ablation-MC-ICP-MS technique. The data obtained here provides a clear demonstration that the HTR-MC-ICP-MS technique can become a powerful tool for monitoring elemental and isotope ratios from NPs of multiple components.


The Philippines has been more cautious in its policy towards free trade agreements (FTAs) than other ASEAN member states, having signed, so far, only one bilateral agreement with Japan in addition to the various ASEAN+1 agreements. While the Government is expected to progressively reduce preferential tariffs to zero, Philippine firms have historically been slow to take advantage of FTAs. This survey reaffirms that this awareness and the usage of FTAs need significant improvement among both manufacturing and services sector firms. Identified as the main source of information for FTAs, the Government needs to increase the efficiency, scope and reach of its promotional and technical training programmes and to rely further on technology to deliver results. These efforts to enhance FTA utilisation are directly linked with the easing of rules of origin (ROOs) compliance and administration. At the national level, these efforts include reforms towards electronic Certificates of Origin (COOs) and selfcertification, and linkage to the national single window (NSW). This will improve timelines and ease the entry of micro, small and medium enterprises. Regional efforts to harmonise ROOs can increase FTA utilisation across ASEAN member countries and pave the way for the forthcoming Regional Comprehensive Economic Partnership (RCEP).


The increasing penetration of wind power, alongside other variable renewable energy (VRE) resources, offers significant potential for decarbonizing power grids. This potential is particularly promising in Norway, where the power system is heavily reliant on hydropower and offers substantial opportunities for wind energy development. However, effectively and reliably operating VRE resources poses significant challenges due to their inherent uncertainty. The intermittent and unpredictable nature of VRE resources presents both technical and economic obstacles to their seamless integration into power systems. To address these challenges, this study focuses on optimizing the scheduling of wind power for a single time step, while considering the uncertainty associated with wind generation forecasts and its impact on producer profitability. The primary objective is to expand an existing stochastic hydropower scheduling model and create an integrated wind-hydro scheduling tool that captures the dynamic interactions between these two power systems. The study's findings indicate that higher up-regulation prices lead to lower bids from wind producers, as they seek to avoid penalties resulting from overestimating their production.


This paper aims to evaluate Food Intensification Program and to examine sustainable strategic of this program in Timor Tengah Utara Regency. This study used mixed methods approach, exploratoy sequential, data come from inteview and the result used for collecting quantitative data with A'WOT method. The results show that the implementation of this program has not been strictly driven as be planned. This caused by several reasons. The prioritized strategy, result from A'WOT analysis is increasing the intensity of counseling and formation of farmer groups for the improvement of farmers' resources. This study recommends several important points, such follow: (1) theory of planning and theory ini planning needed to improve effective plannings, (2) To provide intensive assistances, by increasing the capacity of field assistances, in order to change the behavior of farming communities.


In view of the growing recognition of the pathogenic role of the adrenosympathetic humoral neurotransmitters in the heart muscle as chemical anoxia-producing agents, cardiac "sympathin" was extracted and assayed both colorimetrically and biologically, and some of its chemical and pharmacodynamic properties were studied in detail. It proved to be at least in part identical with nor-epinephrine (arterenol) and to exert effects analogous to those of epinephrine and nor-epinephrine upon blood pressure, heart rate and the electrocardiogram (depression or inversion of the T wave). Its action was intensified by cocaine and counteracted by nitroglycerine.