Scaling ratios of simulations are essential to research the effect of tornadic winds on buildings and structures, in both experimental and numerical studies. In order to determine the proper scaling, access to wind fields of simulated and full-scale tornadoes is needed. For the first time here Doppler radar tornado velocity fields are analyzed and compared to experimental tornado-like vortices data in order to establish the scaling necessary to simulate tornadoes in a physical laboratory setting.
A prototype three-dimensional wind testing chamber capable of simulating tornadoes, named Model WindEEE Dome (MWD), was designed and built. Tornado-like vortices were simulated and investigated for swirl ratios ranging from 0.12 to 1.29. Flow visualization captured a laminar single-celled core at very low swirl ratios, a vortex breakdown bubble formation and then the drowned vortex jump at moderate swirl ratios, and a two-celled turbulent vortex at high swirl ratios. The surface static pressure of simulated tornadoes was measured and the mean velocity field of the tornado-like vortices was characterized using Particle Image Velocimetry method. It was shown that for radial Reynolds numbers greater than 6.7×104, the core radius and the swirl ratio corresponding the transition from laminar to turbulent are nearly independent of the radial Reynolds number. Local peaks in the axial profile of the tangential velocities near the surface, together with the very large surface pressure deficits, observed in the experimental data, are distinctive characteristics of tornado-like vortices and may be responsible for structural damages in tornadic winds.
Nine volumes of single-Doppler radar data obtained from five tornado events were analyzed using the Ground-Based Velocity Track Display method and a unique dataset of three-dimensional axisymmetric tornado flow fields was created. This full-scale dataset contains various vortex structures spanning from a weak single-celled vortex to a very strong two-celled vortex and wind fields with the overall maximum tangential velocities ranging from 36.3 m/s to 62 m/s. The structure of the vortex was discussed in detail for each volume of data. The swirl ratio of the full-scale data was calculated and related to the forensic EF-Scale (Enhanced Fujita Scale) for each volume. It was observed that swirl ratio increases as the tornado vortex intensifies which is consistent with laboratory results.
Lastly, experimentally simulated tornado-like vortices were compared to the field tornadoes. The length and velocity scaling ratios of the simulation and the swirl ratio of the full-scale tornadoes were identified. It is concluded that the MWD apparatus can generate tornado-like vortices equivalent to EF0 to low-end EF3 rated tornadoes in nature. Also, an average length scale of 1550 is determined for simulating mid-range EF1 to low-end EF3 rated tornadoes with fully turbulent flow characteristics.


OF DISSERTATION BARRIERS TO EFFECTIVE PAIN MANAGEMENT IN PRETERM AND CRITICALLY ILL NEONATES The purpose of this dissertation is to explore potential barriers nurses experience in providing effective pain management for preterm and critically ill infants in neonatal intensive care units (NICUs). The specific aims of the study conducted are to examine (a) NICU caregivers' knowledge about pain, (b) scales used to evaluate pain in infants, (c) NICU nurses' documented pain practices, and (d) bias in treating pain of certain types of infants. This dissertation is comprised of three manuscripts. The first manuscript is an integrated review of the literature describing caregiver knowledge, barriers, and bias in the management of pain in neonates. The second manuscript is a systematic review of multidimensional pain scales developed for use in preterm and critically ill infants. The final manuscript reports a descriptive exploratory study designed to examine nurses' knowledge of pain, knowledge of intensity and appropriate management of procedural pain, bias in treating pain of certain types of infants, and documented pain management practices. Over the past 25 years, caregiver knowledge of pain in preterm and critically ill infants has advanced from beliefs that neonates do not feel pain, to the knowledge that preterm infants experience more pain than term infants, older children, and adults. Nine multidimensional pain scales with varying levels of reliability and validity have been developed, yet a gold standard for pain assessment in preterm and critically ill neonates has not emerged. In this study, baccalaureate prepared nurses (BSN) and nurses with higher total years of nursing experience had better knowledge of pain in this population than associate degree nurses (ADN). However, pain management was inconsistent, resulting in pain that was untreated as often as 80% of the time. Nurses reported that physician practice was the primary obstacle to providing effective pain management. Additional concerns included knowledge deficits of nurses and physicians, lack of communication and teamwork, and rushed care. Nurses reported biases in managing pain and were less likely to invest time and energy treating the pain of infants experiencing neonatal abstinence syndrome.


The study was conducted to investigate the antibacterial efficacy against enteropathogenic E. coli of plants commonly used to treat calf-diarrhoea. Methanolic extracts of six plants (Aegle marmelos, Curcuma longa, Dalbergia sissoo, Mangifera indica, Psidium guajava and Punica granatum) were screened for their antibacterial property against enteropathogenic E. coli by standard disc diffusion method. Minimum inhibitory concentration (MIC) and of the extract exhibiting highest antibacterial activity was estimated by broth dilution method and minimum bactericidal concentration (MBC) was measured by streaking the contents of MIC tubes on nutrient agar plates. Among the six extracts tested, only extracts of Curcuma longa, Psidium guajava and Punica granatum exhibited antibacterial activity against E. coli. Out of these three, Punica granatum extract was found to be most effective with a mean inhibition zone of 14.67±0.577 mm followed by Psidium guajava (9.67±0.577 mm) and Curcuma longa (8.67±0.577 mm), produced by the disc containing 8.00 mg of respective extract. Minimum inhibitory concentration and minimum bactericidal concentration of the Punica granatum extract were estimated to be 02.00 mg/mL and 03.00 mg/mL respectively. These findings suggest that methanolic extracts of Curcuma longa, Psidium guajava and Punica granatum possess antibacterial activity against enteropathogenic E.coli


The aim of this work was to optimize and validate, by intralaboratorial procedures, a method for the determination of patulin in grapes by thin-layer chromatography. The steps of extraction, cleanup, detection and quantification were optimized. For the validation of the method, recovery assays with standard solutions and artificially contaminated samples were carried out. The mean recovery and the variation coefficient were 65.4% and 7.58%, respectively. The optimized conditions were: 50 mL of grape juice, three extraction stages (with 100 mL of ethyl acetate in the first stage and 50 mL in second and third stages), and 100 µL of ethanol to solubilize the extract. The solvent-system used was toluene - ethyl acetate - formic acid (6:3:1), and 0.5% MBTH in 5% formic acid was sprayed on the plates to intensify the fluorescence. The visual detection and quantification limits were 7.44 ng and 15.87 µg.kg-1, respectively. The optimized and validated method demonstrated sufficient efficiency for adoption in the monitoring of patulin in grape.


In this paper we describe spacecraft and underwater vehicle dynamics with small-amplitude, periodically time-varying forcing. The dynamic descriptions are derived so that they can be used to prescribe forcing laws for controlling the motion of these systems when they are underactuated, i.e., when the number of force inputs is less than the dimension of the configuration space. The use of periodic force inputs is motivated by the demonstrated success of using periodic velocity inputs in the associated nonholonomic kinematic spacecraft and underwater vehicle motion control problems, e.g., controlling underactuated spacecraft driven with internal rotors and underwater vehicles at low Reynolds number. By now addressing dynamic as well as kinematic response, we provide results that are useful in many practical problems in which the system cannot be modelled as purely kinematic, e.g., controlling underactuated spacecraft driven with gas jets and underwater vehicles at high Reynolds number.


Wireless Mesh Networks (WMNs) have gained considerable popularity recently. Most research on WMNs focuses on improving network capacity, because WMNs suffer from severe throughput degradation due to interferences. Among them, routing has been an active area of research for a long time, and it is also the focus of this dissertation.
Routing metrics are critical for selection of a path with a maximum throughput in multi-hop wireless networks. Due to the nature of wireless losses and multi-rate support, wireless links in one single network may have a broad range of characteristics such as loss rates and data transmission rates. In addition, wireless nodes may be equipped with multiple radios tuned to non-overlapping channels in order to improve network performance. All these technologies bring new challenges to route selection in wireless multi-hop networks, and the traditional minimum hop count metric does not suffice in such a complicated environment, since it does not take any aforementioned characteristics into account.
To design an effective routing metric, it is necessary to accurately acquire the link properties that might affect path performance, most importantly, the loss rate. To better assess individual link loss rate, this study proposes several modifications to existing broadcast based probe method that leads to a more accurate link loss rate measurement. In recent years, although many link quality-based routing metrics have been explored, none of the current routing metrics is capable of capturing the necessary link properties, which is critical for a comprehensive evaluation of routing path performances and the selection of the best route. In this study, we explore the drawbacks of current routing metrics and propose two improved strategies, improved Expected Time Transmission (iETT) and improved Bottleneck Aware Transmission Delay (iBATD), respectively, to address the challenges for single-radio and multi-radio wireless mesh networks. The proposed routing metrics will be explored in various wireless network scenarios through ns-2 simulations and their performances will be compared to current routing metrics, such as minimum hop count metric (HOP), Expected Transmission Count (ETX), Expected Transmission Time (ETT) and Weighted Cumulative ETT (WCETT) metrics. Additionally, an extended Dynamic Source Routing (DSR)-based routing protocol (eDSR), which works effectively in multi-radio scenarios and performs seamlessly with any quality aware routing metrics, has also been designed to aid the performance comparisons. Moreover, we develop iETT routing metric and three other selected representative routing metrics on a Linux based test bed and assess their performances with extensive experiments.


As some of the most widely utilised intercellular signalling molecules, transforming growth factor β (TGFβ) superfamily members play critical roles in normal development and become disrupted in human disease. Establishing appropriate levels of TGFβ signalling involves positive and negative feedback, which are coupled and driven by the same signal transduction components (R-Smad transcription factor complexes), but whether and how the regulation of the two can be distinguished are unknown. Genome-wide comparison of published ChIP-seq datasets suggests that LIM domain binding proteins (Ldbs) co-localise with R-Smads at a substantial subset of R-Smad target genes including the locus of inhibitory Smad7 (I-Smad7), which mediates negative feedback for TGFβ signalling. We present evidence suggesting that zebrafish Ldb2a binds and directly activates the I-Smad7 gene, whereas it binds and represses the ligand gene, Squint (Sqt), which drives positive feedback. Thus, the fine tuning of TGFβ signalling derives from positive and negative control by Ldb2a. Expression of ldb2a is itself activated by TGFβ signals, suggesting potential feed-forward loops that might delay the negative input of Ldb2a to the positive feedback, as well as the positive input of Ldb2a to the negative feedback. In this way, precise gene expression control by Ldb2a enables an initial build-up of signalling via a fully active positive feedback in the absence of buffering by the negative feedback. In Ldb2a-deficient zebrafish embryos, homeostasis of TGFβ signalling is perturbed and signalling is stably enhanced, giving rise to excess mesoderm and endoderm, an effect that can be rescued by reducing signalling by the TGFβ family members, Nodal and BMP. Thus, Ldb2a is critical to the homeostatic control of TGFβ signalling and thereby embryonic patterning.


The 2017 Australian and Canadian 24-hour movement guidelines recommend infants receive 30 minutes of tummy time daily. Currently, there are no validated objective measurement tools or devices to assess tummy time. The purpose of this study was to: 1) test the practicality of using devices on infants as an objective measure of tummy time, and 2) test the accuracy of developed algorithms and cut-points for predicting prone posture. Thirty-two healthy infants aged 4 to 25 weeks completed a protocol of 12 positions. Infants were placed in each position for 3 minutes while wearing a MonBaby (chest), GENEActiv (right hip) and two ActiGraphs (right hip and ankle). Direct observation was the criterion measure. The accuracy of the algorithms or cut-points to predict prone on floor, non-prone and prone supported positions were analyzed. Parents also completed a practicality questionnaire. Algorithms and cut-points to classify posture using devices from MonBaby, GENEActiv and ActiGraph (hip and ankle) were 79%, 95%, 90% and 88% accurate at defining tummy time and 100%, 98%, 100% and 96% accurate at defining non-prone positions, respectively. GENEActiv had the smallest mean difference and limits of agreement (-8.4s, limits of agreement [LoA]: -78.2 to 61.3s) for the prone on floor positions and ActiGraph Hip had the smallest mean difference and LoA for the non-prone positions (-0.2s, LoA: -1.2 to 0.9s). The majority of parents agreed all devices were practical and feasible to use with MonBaby being the preferred device. The evaluated algorithms and cut-points for GENEActiv and ActiGraph (hip) are of acceptable accuracy to objectively measure tummy time (time spent prone on floor). Accurate measurement of infant positioning practices will be important in the observation of 24-hour movement guidelines in the early years.


Rainfall event is the very specific, reliable unambiguous precursor for the earthquake event. Over the years scientists have hunted for some signal—a precursory sign, however faint—that would allow forecasters to pin-point exactly where and when the big ones will hit. After decades spent searching in vain, many seismologists now doubt whether such a signal even exists. But in a great surprise to everyone, from an ordinary lay man to eminent scientists, 100% earthquakes occur after rainfalls! Though I have the findings for the entire regions of the world, here E Turkey are the region for submission for the period Jan-November, 2012 to study the strong correlation and show the strong evidence to prove that the 100% earthquakes after rainfall in a consistence manner. Anyone can very easily verify the validity of the findings for any forthcoming earthquakes for any regions of E Turkey in just two weeks of period. Nature does not give two different results for the same phenomena, for two different observers. Though there exists a very strong relation between the rainfalls and the earthquakes, scientists and seismologists have not been able to detect and identify this rainfall precursory signal for hundreds of years that consistently occurs before earthquakes. The methodology of rainfall event before earthquakes, even works consistently for earthquake prediction purpose, especially in any regions of the world. Rainfall type precursor is the best approach to predict specific earthquakes, which provide the potential for estimating the epicenter and magnitude of any moderate to strong earthquakes. Earthquakes are more likely when there is rain than it is not. The magnitudes of a resulting individual earthquake depend on the severity of the weather changes. However, in a very few cases the time scales and magnitude do vary substantially as a consequence of local site geology and other factors.


This book is appropriate for any standalone Computers and Society or Computer Ethics course offered by a computer science, business, or philosophy department, as well as special modules in any advanced CS course. In an era where information technology changes constantly, a thoughtful response to these rapid changes requires a basic understanding of IT history, an awareness of current issues, and a familiarity with ethics. Ethics for the Information Age is unique in its balanced coverage of ethical theories used to analyze problems encountered by computer professionals in today's environment. By presenting provocative issues such as social networking, government surveillance, and intellectual property from all points of view, this market-leading text challenges students to think critically and draw their own conclusions, which ultimately prepares them to become responsible, ethical users of future technologies. Teaching and Learning Experience This program presents a better teaching and learning experience-for you and your students. It will help: *Encourage Critical Thinking: A balanced, impartial approach to ethical issues avoids biased arguments, encouraging students to consider and analyze issues for themselves. *Keep Your Course Current and Relevant: A thoughtful response to information technology requires an awareness of current information-technology-related issues. *Support Learning: Resources are available to expand on the topics presented in the text.


While XML has become the de facto standard to represent structured data, common XML schema languages are quite restricted in their definition capability. Structural constraints are widely used throughout all schema languages, some languages also support global reference constraints, yet integrity constraints based on local references or values and arithmetic comparisons are uncommon. Data binding techniques, connecting XML with programming languages in a more typesafe way than SAX or DOM, exist for most commonly used schema languages. These techniques are only capable of handling structural constraints. This thesis proposes and implements a binding between schemata supporting more data-centric constraints and class-based object oriented languages. The binding generates class files from a schema file, defines a translation between objects and documents, and checks adherence to integrity constraints of documents and manipulations performed on the objects. The binding puts focus on correctness of constraint checks and usability of the generated library, using several heuristics to assist the user rather than supporting unorthodox schema definitions.


The goal of these notes is to give a reasonably complete, although not exhaustive, discussion of what is commonly referred to as the Hopf bifurcation with applications to specific problems, including stability calculations. Historically, the subject had its origins in the works of Poincare [1] around 1892 and was extensively discussed by Andronov and Witt [1] and their co-workers starting around 1930. Hopf's basic paper [1] appeared in 1942. Although the term "Poincare-Andronov-Hopf bifurcation" is more accurate (sometimes Friedrichs is also included), the name "Hopf Bifurcation" seems more common, so we have used it. Hopf's crucial contribution was the extension from two dimensions to higher dimensions.

The principal technique employed in the body of the text is that of invariant manifolds. The method of Ruelle-Takens [1] is followed, with details, examples and proofs added. Several parts of the exposition in the main text come from papers of P. Chernoff, J. Dorroh, O. Lanford and F. Weissler to whom we are grateful.

The general method of invariant manifolds is common in dynamical systems and in ordinary differential equations; see for example, Hale [1,2] and Hartman [1]. Of course, other methods are also available. In an attempt to keep the picture balanced, we have included samples of alternative approaches. Specifically, we have included a translation (by L. Howard and N. Kopell) of Hopf's original (and generally unavailable) paper. These original methods, using power series and scaling are used in fluid mechanics by, amongst many others, Joseph and Sattinger [1]; two sections on these ideas from papers of Iooss [1-6] and Kirchgassner and Kielhoffer [1] (contributed by G. Childs and O. Ruiz) are given.

The contributions of S. Smale, J. Guckenheimer and G. Oster indicate applications to the biological sciences and that of D. Schmidt to Hamiltonian systems. For other applications and related topics, we refer to the monographs of Andronov and Chaiken [1], Minorsky [1] and Thom [1].

The Hopf bifurcation refers to the development of periodic orbits ("self-oscillations") from a stable fixed point, as a parameter crosses a critical value. In Hopf's original approach, the determination of the stability of the resulting periodic orbits is, in concrete problems, an unpleasant calculation. We have given explicit algorithms for this calculation which are easy to apply in examples. (See Section 4, and Section 5A for comparison with Hopf's formulae). The method of averaging, exposed here by S. Chow and J. Mallet-Paret in Section 4C gives another method of determining this stability, and seems to be especially useful for the next bifurcation to invariant tori where the only recourse may be to numerical methods, since the periodic orbit is not normally known explicitly.

In applications to partial differential equations, the key assumption is that the semi-flow defined by the equations be smooth in all variables for t > O. This enables the invariant manifold machinery, and hence the bifurcation theorems to go through (Marsden [2]). To aid in determining smoothness in examples we have presented parts of the results of Dorroh-Marsden. [1]. Similar ideas for utilizing smoothness have been introduced independently by other authors, such as D. Henry [1].

Some further directions of research and generalization are given in papers of Jost and Zehnder [1], Takens [1, 2], Crandall-Rabinowitz [1, 2], Arnold [2], and Kopell-Howard [1-6] to mention just a few that are noted but are not discussed in any detail here. We have selected results of Chafee [1] and Ruelle [3] (the latter is exposed here by S. Schecter) to indicate some generalizations that are possible.

The subject is by no means closed. Applications to instabilities in biology (see, e.g. Zeeman [2], Gurel [1-12] and Section 10, 11); engineering (for example, spontaneous "flutter" or oscillations in structural, electrical, nuclear or other engineering systems; cf. Aronson [1], Ziegler [1] and Knops and Wilkes [1]), and oscillations in the atmosphere and the earth's magnetic field (cf. Durand [1]) are appearing at a rapid rate. Also, the qualitative theory proposed by Ruelle-Takens [1] to describe turbulence is not yet well understood (see Section 9). In this direction, the papers of Newhouse and Peixoto [1] and Alexander and Yorke [1] seem to be important. Stable oscillations in nonlinear waves may be another fruitful area for application; cf. Whitham [1]. We hope these notes provide some guidance to the field and will be useful to those who wish to study or apply these fascinating methods.

After we completed our stability calculations we were happy to learn that others had found similar difficulty in applying Hopf's result as it had existed in the literature to concrete examples in dimension ≥ 3. They have developed similar formulae to deal with the problem; cf. Hsu and Kazarinoff [1, 2] and Poore [1].

The other main new result here is our proof of the validity of the Hopf bifurcation theory for nonlinear partial differential equations of parabolic type. The new proof, relying on invariant manifold theory, is considerably simpler than existing proofs and should be useful in a variety of situations involving bifurcation theory for evolution equations.

These notes originated in a seminar given at Berkeley in 1973-4. We wish to thank those who contributed to this volume and wish to apologize in advance for the many important contributions to the field which are not discussed here; those we are aware of are listed in the bibliography which is, admittedly, not exhaustive. Many other references are contained in the lengthy bibliography in Cesari [1]. We also thank those who have taken an interest in the notes and have contributed valuable comments. These include R. Abraham, D. Aronson, A. Chorin, M. Crandall., R. Cushman, C. Desoer, A. Fischer, L. Glass, J. M. Greenberg, O. Gurel, J. Hale, B. Hassard, S. Hastings, M. Hirsch, E. Hopf, N. D. Kazarinoff, J. P. LaSalle, A. Mees, C. Pugh, D. Ruelle, F. Takens, Y. Wan and A. Weinstein. Special thanks go to J. A. Yorke for informing us of the material in Section 3C and to both he and D. Ruelle for pointing out the example of the Lorentz equations (See Example 4B.8). Finally, we thank Barbara Komatsu and Jody Anderson for the beautiful job they did in typing the manuscript.

Jerrold Marsden
Marjorie McCracken


Agent-based approaches to manufacturing scheduling and control have gained increasing attention in recent years. Such approaches are attractive because they offer increased robustness against the unpredictability of factory operations. But the specification of local coordination policies that give rise to efficient global performance and effectively adapt to changing circumstances remains an interesting challenge. In this paper, we introduce a new approach to this coordination problem, drawing on various aspects of a computational model of how wasp colonies coordinate individual activities and allocate tasks to meet the collective needs of the nest. We focus specifically on the problem of configuring machines in a factory to best satisfy (potentially changing) product demands over time. Our system models the set of jobs queued in front of any given machine as a wasp nest, wherein wasp-like agents interact to form a social hierarchy and prioritize the jobs that they represent. Other wasp-like agents external to the nest act as overall machine proxies, and use a model of wasp task allocation behavior to determine which new jobs should be accepted into the machine's queue. We show for simple factories that our multi-agent system achieves the desired effect. For a given job mix, the system converges to a factory configuration that maximizes overall performance, and as the job mix changes, the system quickly adapts to a new, more appropriate configuration.


Can neural responses of a small group of individuals predict the behavior of large-scale populations? In this investigation, brain activations were recorded while smokers viewed three different television campaigns promoting the National Cancer Institute's telephone hotline to help smokers quit (1-800-QUIT-NOW). The smokers also provided self-report predictions of the campaigns' relative effectiveness. Population measures of the success of each campaign were computed by comparing call volume to 1-800-QUIT-NOW in the month before and the month after the launch of each campaign. This approach allowed us to directly compare the predictive value of self-reports with neural predictors of message effectiveness. Neural activity in a medial prefrontal region of interest, previously associated with individual behavior change, predicted the population response, whereas self-report judgments did not. This finding suggests a novel way of connecting neural signals to population responses that has not been previously demonstrated and provides information that may be difficult to obtain otherwise.


In cosmological scenarios such as the pre-big bang scenario or the ekpyrotic scenario, a matching condition between the metric perturbations in the pre-big bang phase and those in the post big bang phase is often assumed. Various matching conditions have been considered in the literature. Nevertheless obtaining a scale-invariant CMB spectrum via a concrete mechanism remains impossible. In this paper, we examine this problem from the point of view of local causality. We begin with introducing the notion of local causality and explain how it constrains the form of the matching condition. We then prove a no-go theorem: independent of the details of the matching condition, a scale-invariant spectrum is impossible as long as the local causality condition is satisfied. In our framework, it is easy to show that a violation of local causality around the bounce is needed in order to give a scale-invariant spectrum. We study a specific scenario of this possibility by considering a nonlocal effective theory inspired by noncommutative geometry around the bounce and show that a scale-invariant spectrum is possible. Moreover we demonstrate that the magnitude of the spectrum is compatible with observations if the bounce is assumed to occur at an energy scale whichmore » is a few orders of magnitude below the Planckian energy scale.« less


Most real-time heuristic search algorithms solve search problems by executing a series of episodes. During each episode the algorithm decides an action for execution. Such a decision is usually made using information gathered by running a bounded, heuristic-search algorithm. In this paper we report on a real-time search algorithm that does not use a search algorithm to choose the next action to be applied. Rather, it uses a neural network whose input is local information about the search graph, comparable to the information that would be used by a bounded search algorithm. We describe a supervised learning approach to training such a network. Our three types of maps from the Moving AI benchmarks, shows that our algorithm is, in some cases, substantially superior to algorithms that have access to the same information about the graph. One of our most important conclusions is that our extended set of features important: indeed, using features beyond the heuristic seems key to achieving good performance.


The acoustic properties of anti-inflammatory egonol were investigated by using micro-Brillouin scattering spectroscopy, by use of a 6-pass tandem Fabry-Perot interferometer and an optical microscope specially modified for spectroscopic purposes. The measured Brillouin spectrum was composed of a central peak centered at zero and a Brillouin doublet arising from the longitudinal acoustic waves, i.e. propagating density fluctuations. For the first time, the glass transition of egonol was identified to be about $5^{\circ}C$ at which the Brillouin peak position and the half width showed abrupt changes. The substantial damping of acoustic phonons of egonol near the glass transition temperature indicated that the contribution of internal relaxation processes such as small-amplitude librations of side chains to the damping of acoustic phonons may be substantial depending on the internal structure of molecules.


Recent microarray studies have identified distinct subtypes of breast tumors that arise from different cell types and that show statistically significant differences in patient outcome. To gain insight into these differences, we identified in vitro and in vivo changes in gene expression induced by chemotherapeutics. We treated two cell lines derived from basal epithelium (immortalized human mammary epithelial cells) and two lines derived from luminal epithelium (MCF-7 and ZR-75–1) with chemotherapeutics used in the treatment of breast cancer and assayed for changes in gene expression using DNA microarrays. Treatment doses for doxorubicin and 5-fluorouracil were selected to cause comparable cytotoxicity across all four cell lines. The dominant expression response in each of the cell lines was a general stress response; however, distinct expression patterns were observed. Both cell types induced DNA damage-response genes such as p21waf1, but the response in the luminal cells showed higher fold changes and included more p53-regulated genes. Luminal cell lines repressed a large number of cell cycle-regulated genes and other genes involved in cellular proliferation, whereas the basal cell lines did not. Instead, the basal cell lines repressed genes that were involved in differentiation. These in vitro responses were compared with expression responses in breast tumors sampled before and after treatment with doxorubicin or 5-fluorouracil/mitomycin C. The in vivo data corroborated the cell-type-specific responses to chemotherapeutics observed in vitro, including the induction of p21waf1. Similarities between in vivo and in vitro responses help to identify important response mechanisms to chemotherapeutics.


In light of Los Angeles' gang state of emergency, ethnic and minority gangs are arguably more high profile now than at any other time in our history. News media typically focus on the crime and violence associated with gangs, but not much else. This encyclopedia seeks to illuminate the world of gangs, including gang formations, routine gang activities, aberrations and current developments. One hundred essay entries related to gangs in the United States and worldwide provide a diffuse overview of the gang phenomenon. Each entry defines and explains the term, provides an historical overview, and explains its significance today. As the following entries demonstrate, gangs are part of the fabric of American society. They are not only in our communities but also our schools and other social institutions. Understanding the world of gangs is therefore needed to understand American society. Entries include: Bikers, Bloods, Cholas, Crips, gang mythology, gang warfare, graffiti, Hell's Angels, Hong Kong Triads, Latin Kings, law enforcement, occultic gangs, mafia, media, prison gangs, rites, Skinheads, Streetgang Terrorism Omnibus Prevention Act, tattoos, trafficking, Wanna-bes, West Side Story, Witness Protection programs, and youth gangs.


Objective: To determine whether transferring equipment designed to assist a carer when moving someone who is able to take some weight through their legs is likely to affect the risk of back problems in the carer. Design: Twelve pieces of equipment were tested by nurses transferring patients from commode to wheelchair and vice versa, and from wheelchair to bed and vice versa. Video recordings were taken of each transfer and freeze-frame pictures at the moment of greatest load were analysed. Compressive disc force was deduced, using a biomechanical model, from the weights of the patient and nurse and measurements of anatomical distances and angles. Setting: The Sir Walter Puckey Gait Laboratory, in the Rehabilitation Research Unit, University of Southampton. Subjects: Six female trained nurses with no recent history of hernia, back pain or pregnancy during the previous six months were recruited to use the equipment. Two female patients were chosen from those volunteering and screened for stroke, confusion and unusual footwear. The patients were able to partially weight-bear and were used to being transferred. Results: The results indicate that the critical value of 3.4 kN at the L5/S1 disc (specified by the US National Institute for Occupational Safety and Health) was not exceeded when using transferring equipment. Conclusion: In this study, loading on the spine during transferring tasks with or without equipment was not considered harmful when good technique was employed.


We discuss and calibrate the spectrometry system based on concave reflection grating. The working principle, structure and parameters of the spectrometry system are introduced. For the wavelength calibration problem, three methods are put forward and discussed in detail with formulation calculation method, circular iteration method and interpolation. Interpolation is used to calibrate the concave reflection grating spectrometry system and the error is less than 1 nm. Four spectrum images that the system collected are given in this paper. The experimental results indicate that a spectrometry system can be based on concave reflection grating and be calibrated by interpolation.


Designing and constructing a large space-based science facility requires the integration of constraints and design variables with assembly operations. Development of such a facility requires a process considering assembly techniques, duration of interim stages, contingency allowances, crew allocations, safety, and analytical inputs from many other areas. Development of assembly operations must include payload delivery constraints, system activation and startup requirements, and resource management guidelines. Each step of the assembly process must leave a survivable structure compatible with future assembly procedures. The Assembly Operations group at McDonnell Douglas Space Systems Company-Space Station Division has developed a methodology for including assembly operations in the design process. This methodology requires an analysis of assembly operations and associated impacts before development of operational procedures and manufacture of flight hardware. This methodology aids in the development of assembly operations satisfying operational constraints and requirements by improving integration between hardware, software, and operations. Application of this methodology increases efficiency in scheduling and cost control. Use of these processes helps guarantee successful assembly of a space facility.


As citizens address the issues of climate change, earth-friendly technologies, and jumpstarting a green economy, environmental politics has gained a prominent position on the American political landscape. "U.S. Environmental Policy and Politics: A Documentary History" shows readers the many ways throughout American history in which environmental concerns have intersected with issues of energy production and consumption, government regulation, private property rights, economic growth, and lifestyle choices. The primary sources featured in the book illuminate essential events and environmental controversies that have roiled the waters of American politics and policymaking from the colonial era to the twenty-first century. This volume opens with a narrative overview which develops the major environmental themes discussed in the chapters and documents that follow. Each chapter leads with a comprehensive narrative that provides background information necessary for understanding the significance of the primary documents. The wide-ranging document collections include over 150 full and excerpted speeches, writings by conservationists, federal and state legislation, court opinions, testimonies, policy briefs, and more. The documents are preceded by context-setting headnotes which provide information on the key players and events. Some of the topics covered include: population growth and territorial expansion; toxins and waste disposal; air pollution and climate change; wilderness and species protection; energy production; conservation and environmental justice; land and water use; urban development and public health; mining and logging. A timeline listing major events from the colonial era to the present provides an overview of U.S. environmental history, while illustrations and an index further supplement this title. "U.S. Environmental Policy and Politics" is well-suited for collections at academic, community college, and public libraries. It key features: thematic, primary source documents; and, chronological chapters from colonial era to the present. It addresses current concerns about climate change and energy conservation. It tracks the rise of regulatory agencies.


The United States needs support from other states to carry out global governance, particularly from rising powers such as China and Russia. Securing cooperation from China and Russia poses special problems, however, because neither state is part of the liberal Western community, ruling out appeals to common values and norms. Nevertheless, an alternative approach that is rooted in appreciation of China's and Russia's heightened status concerns may be viable. Since the end of the Cold War, Chinese and Russian foreign policy has been shaped by the goal of restoring both countries' great power status, which received major blows after China's Tiananmen Square repression and the Soviet Union's breakup and loss of empire. This desire for status can be explained by social identity theory, which argues that social groups strive for a distinctive, positive identity. Social identity theory provides a typology of strategies that states may use to enhance their relative status and suggests appropriate responses to status concerns of rising powers. Redirecting scholarly attention to status considerations and incentives could contribute to a diplomatic strategy for engaging rising powers.


The higher product requirements (reduced weight, increased safety, lower emissions…) have meant that a larger number of car body parts must be made in advanced high strength steels. With a reduced lifecycle of a car model from 7 to 5 years this leads to a need for reducing the manufacturing cost and lead time for the tool and die design and manufacturing. The main purpose of this investigation is to establish cost- and lead-time reducing guidelines for selection of tool concepts (choice of die materials, hardening methods and geometry) for different production volume scenarios with respect to sheet materials quality (MS-UHSS) and thickness, without increased die maintenance costs. In this study the cutting edge geometry has been evaluated in respect to the cutting edge radius and the angle of the upper tool. Experimental testing together with FE simulation has been used. Results show that an angle of 93° on the upper cutting edge initially can reduce the cutting work by 14%. Results also shows that by using a cutting edge radius of 80µm, the tool "wear in phase" can be more controlled. Wear test up to 150 000 strokes have been made to evaluate different tool concepts using laser hardened cast iron, cast steel and wrought steel as die material. Sheet material tested was 220RP, DP600, DP800, 700MC and DP1000, with a thickness of t=2mm. The result leads to recommendations for industrial verification. Results among other recommendations are: laser hardened EN-JS-2070 up to 500 000 parts against 220RP and Sleipner up to 1 500 000 parts against 1000DP.


The functional brain connectivity studies are generally based on the synchronization of the resting-state functional magnetic resonance imaging (fMRI) signals. Functional connectivity measures usually assume a stable relationship over time; however, accumulating studies have reported time-varying properties of strength and spatial distribution of functional connectivity. The present study explored the modulation of functional connectivity between two regions by a third region using the physiophysiological interaction (PPI) technique. We first identified eight brain networks and two regions of interest (ROIs) representing each of the networks using a spatial independent component analysis. A voxel-wise analysis was conducted to identify regions that showed modulatory interactions (PPI) with the two ROIs of each network. Mostly, positive modulatory interactions were observed within regions involved in the same system. For example, the two regions of the dorsal attention network revealed modulatory interactions with the regions related to attention, while the two regions of the extrastriate network revealed modulatory interactions with the regions in the visual cortex. In contrast, the two regions of the default mode network (DMN) revealed negative modulatory interactions with the regions in the executive network, and vice versa, suggesting that the activities of one network may be associated with smaller within network connectivity of the competing network. These results validate the use of PPI analysis to study modulation of resting-state functional connectivity by a third region. The modulatory effects may provide a better understanding of complex brain functions.


ALA 2010—San Francisco Melville and Religious Experience CHAIR: BRIAN YOTHERS, UNIVERSITY OF TEXAS AT EL PASO Participants in "Melville and Religious Experience" panel at ALA 2010, from left to right: William E. Engel, Jonathan A. Cook, Richard Hardack, Peter Norberg, Brian Yothers. Few writers have engaged more subtly or more broadly with the subject of religious experience than Melville. On both a cognitive and an affective level, Melville's work is in dialogue with a staggering range of religious traditions. Panelists were invited to consider the following C © 2010 The Authors Journal compilation C © 2010 The Melville Society and Wiley Periodicals, Inc. L E V I A T H A N A J O U R N A L O F M E L V I L L E S T U D I E S 131


This dissertation provides the conceptual and aesthetic background of the compositions composed throughout the course of my doctoral studies. I will introduce Korean philosophies and aesthetics and then expand upon these elements to
demonstrate how they have influenced my approach to music composition. Furthermore, I will demonstrate how I intertwine the use of colour and Korean philosophies. Chapter 1 delineates the elements of Korean philosophies and aesthetics that have influenced my musical language. The chapter focuses on how the Korean handcraft art Jogakbo and the Korean philosophies of Yin-Yang, Ohang and Meak are related to each other. Additionally, I examine the origin and structure of Jogakbo, with a particular focus upon the key variables of shape and colour. The examination of Jogakbo causes me to establish how form and structure are linked in Jogakbo, and then how I apply this form and structure to my composition.
Furthermore, I will describe how the aesthetics of Yin-yang, Ohang and Jogakbo form the core of my musical language by examining the function and unplanned approach to the different coloured scraps of material in Jogakbo. Drawing upon this
examination, I describe how I have taken the colours from these scraps to form the colours in my music. In relation to this, I investigate the musical techniques of spectral composers, with an emphasis on musical colour, looking at specific
composers' techniques and establishing how they have influenced my own compositional techniques. Finally, I will discuss the role of the philosophy of Maek generating linearity on the horizontal structure of music. Chapter 2 discusses
individual portfolio pieces composed throughout the doctoral course chronologically. I will demonstrate how selected Korean philosophies, aesthetics, and the techniques of Jogakbo have gradually evolved to play a larger role in the composition of my pieces. In particular, the colours used in Jogakbo and the philosophy of Ohang play a more direct role in creating the structure and form of the pieces composed in late course. In the conclusion, the research throughout my doctoral course has been summarised, and limitations and other challenges reached while applying the research to my compositional process are examined. Finally, the conclusion ends with a discussion of potential directions to further this research.


5G is closer than ever, considering that in 2020 it will have been released. Existing technologies do not adequately cover the 5G demands, therefore new or modified versions of the existing technologies should be introduced. Telecommunication operators remain skeptical about the costs induced by 5G technologies. In this context, it is fundamental that 5G enabling technologies are analyzed in a techno-economic way. In this paper, authors present models of Cognitive Radio (CR) and Software Defined Networking (SDN). They develop economic models based on the Stackelberg competition, opt for the experimentation parameters and conduct Sensitivity Analysis (SA) experiments that show which are the most influential factors for each technology proposing ways to limit them.


OBJECTIVE
We previously reported high Systemic Lupus International Collaborating Clinics (SLICC) scores in fatal cases of systemic lupus erythematosus (SLE) from our inception cohort. This study was done to clarify if the SLICC damage scores 5 years after diagnosis predicted the outcome.

METHODS
We studied 80 patients with SLE (70 women, 10 men), all enrolled and diagnosed during the years 1981 through 1991 in our inception cohort, and all alive 5 years after inclusion into the cohort. In all patients the SLICC/American College of Rheumatology (ACR) damage index (DI) was scored at 5 years after SLE diagnosis, and these scores were tested for predictive value. The outcomes were survival or late mortality within the following median observation period of 7 years. All surviving patients were followed through 1999, and no patient was lost to followup.

RESULTS
At study entry, 5 years after the diagnosis of SLE, 37 patients had no damage to score with SLICC. Of the remaining 43 patients, 25 had a score of 1 and 18 had a score of 2 or more. In total, 14 fatalities occurred within 7 years after study entry, 7 among the 18 with initial SLICC/ACR DI of 2 or more compared with 7 fatalities among the 62 with less or no damage (p < 0.01). Cardiovascular or cerebrovascular SLICC/ACR DI items were more common in fatal cases than in survivors (p < 0.001). A SLICC score at 5 years of 2 or more increased the relative risk for fatality by 3.4 (95% CI 1.5-14.4), and had a predictive value of 38%. A SLICC score of 0 at 5 years gave an odds ratio in favor of survival of 0.06 (95% CI 0.0-0.5) and had a predictive value for survival of 97%. During an extended followup for one more year the predictive value of damage for fatalities was even more pronounced (p = 0.003, log-rank).

CONCLUSION
SLICC damage scores registered 5 years after SLE diagnosis have a high predictive value for survival during the following median observation time of 7 years. These data provide strong evidence that the items included in the SLICC score are clinically relevant.


The American National Red Cross is in many ways the iconic symbol for disaster response and recovery. The organization, founded in 1881, has a long track record for coming to the aid of those in need in the wake of wars, natural disasters, and other crises. However, in the wake of recent disasters, the Red Cross has been criticized for underperforming. By combining the literature on bureaucracy in Austrian economics and the literature on monocentricity in the work of Vincent Ostrom and Elinor Ostrom, we provide an analysis of the Red Cross that helps explain the organization's evolution over time and that also yields implications for disaster management more broadly. Specifically, the Red Cross is a bureaucracy that has become increasingly centralized and rigid as it has become further enmeshed with governmental responsibilities.


Mitochondrial malate dehydrogenase (m-MDH; EC 18.104.22.168), from mycelial extracts of the thermophilic, aerobic fungus Talaromyces emersonii, was purified to homogeneity by sequential hydrophobic interaction and biospecific affinity chromatography steps. Native m-MDH was a dimer with an apparent monomer mass of 35 kDa and was most active at pH 7.5 and 52 degrees C in the oxaloacetate reductase direction. Substrate specificity and kinetic studies demonstrated the strict specificity of this enzyme, and its closer similarity to vertebrate m-MDHs than homologs from invertebrate or mesophilic fungal sources. The full-length m-MDH gene and its corresponding cDNA were cloned using degenerate primers derived from the N-terminal amino acid sequence of the native protein and multiple sequence alignments from conserved regions of other m-MDH genes. The m-MDH gene is the first oxidoreductase gene cloned from T. emersonii and is the first full-length m-MDH gene isolated from a filamentous fungal species and a thermophilic eukaryote. Recombinant m-MDH was expressed in Escherichia coli, as a His-tagged protein and was purified to apparent homogeneity by metal chelate chromatography on an Ni2+-nitrilotriacetic acid matrix, at a yield of 250 mg pure protein per liter of culture. The recombinant enzyme behaved as a dimer under nondenaturing conditions. Expression of the recombinant protein was confirmed by Western blot analysis using an antibody against the His-tag. Thermal stability studies were performed with the recombinant protein to investigate if results were consistent with those obtained for the native enzyme.


Wildlife‐originated zoonotic diseases in general are a major contributor to emerging infectious diseases. Hantaviruses more specifically cause thousands of human disease cases annually worldwide, while understanding and predicting human hantavirus epidemics pose numerous unsolved challenges. Nephropathia epidemica (NE) is a human infection caused by Puumala virus, which is naturally carried and shed by bank voles (Myodes glareolus). The objective of this study was to develop a method that allows model‐based predicting 3 months ahead of the occurrence of NE epidemics. Two data sets were utilized to develop and test the models. These data sets were concerned with NE cases in Finland and Belgium. In this study, we selected the most relevant inputs from all the available data for use in a dynamic linear regression (DLR) model. The number of NE cases in Finland were modelled using data from 1996 to 2008. The NE cases were predicted based on the time series data of average monthly air temperature (°C) and bank voles' trapping index using a DLR model. The bank voles' trapping index data were interpolated using a related dynamic harmonic regression model (DHR). Here, the DLR and DHR models used time‐varying parameters. Both the DHR and DLR models were based on a unified state‐space estimation framework. For the Belgium case, no time series of the bank voles' population dynamics were available. Several studies, however, have suggested that the population of bank voles is related to the variation in seed production of beech and oak trees in Northern Europe. Therefore, the NE occurrence pattern in Belgium was predicted based on a DLR model by using remotely sensed phenology parameters of broad‐leaved forests, together with the oak and beech seed categories and average monthly air temperature (°C) using data from 2001 to 2009. Our results suggest that even without any knowledge about hantavirus dynamics in the host population, the time variation in NE outbreaks in Finland could be predicted 3 months ahead with a 34% mean relative prediction error (MRPE). This took into account solely the population dynamics of the carrier species (bank voles). The time series analysis also revealed that climate change, as represented by the vegetation index, changes in forest phenology derived from satellite images and directly measured air temperature, may affect the mechanics of NE transmission. NE outbreaks in Belgium were predicted 3 months ahead with a 40% MRPE, based only on the climatological and vegetation data, in this case, without any knowledge of the bank vole's population dynamics. In this research, we demonstrated that NE outbreaks can be predicted using climate and vegetation data or the bank vole's population dynamics, by using dynamic data‐based models with time‐varying parameters. Such a predictive modelling approach might be used as a step towards the development of new tools for the prevention of future NE outbreaks.


1.Fishing spans all oceans and the impact on ocean predators such as sharks and rays is largely unknown. A lack of data and complicated jurisdictional issues present particular challenges for assessing and conserving high seas biodiversity. It is clear, however, that pelagic sharks and rays of the open ocean are subject to high and often unrestricted levels of mortality from bycatch and targeted fisheries for their meat and valuable fins.
2.These species exhibit a wide range of life-history characteristics, but many have relatively low productivity and consequently relatively high intrinsic vulnerability to over-exploitation. The IUCN — World Conservation Union Red List criteria were used to assess the global status of 21 oceanic pelagic shark and ray species.
3.Three-quarters (16) of these species are classified as Threatened or Near Threatened. Eleven species are globally threatened with higher risk of extinction: the giant devilray is Endangered, ten sharks are Vulnerable and a further five species are Near Threatened. Threat status depends on the interaction between the demographic resilience of the species and intensity of fisheries exploitation.
4.4. Most threatened species, like the shortfin mako shark, have low population increase rates and suffer high fishing mortality throughout their range. Species with a lower risk of extinction have either fast, resilient life histories (e.g. pelagic stingray) or are species with slow, less resilient life histories but subject to fisheries management (e.g. salmon shark).
5.5. Recommendations, including implementing and enforcing finning bans and catch limits, are made to guide effective conservation and management of these sharks and rays.

Copyright © 2008 John Wiley & Sons, Ltd.


The routine use of topical anesthetics to alleviate discomfort associated with in vivo ocular irritancy testing has been advocated. This review provides information about the adverse effects of topical ocular anesthetics and answers the questions: are topical anesthetics practical and effective in ocular irritancy protocols, is long-term use contraindicated, will topical anesthetics alter the response of a test substance, and are there significant side-effects which might cause pain and suffering in test animals? There was no evidence to support the use of a specific topical anesthetic. Further, information about using systemic analgesics or combinations with local anesthetics that would effectively alleviate discomfort associated with ocular irritancy testing without affecting test results was not found. Comprehensive studies are needed to identify the most effective combination of drugs that would ameliorate discomfort associated with ocular irritation testing.


This thesis investigates the development of capabilities by incumbent telecommunications operators in the context of the transition to the Next Generation Network (NGN). In particular, it examines the case of BT in the UK, as a large-scale first mover in this transition. The research is based on recent developments in the telecommunications industry, and the empirical evidence was obtained through documentary analysis and a large number of interviews. Using the resource-based view (RBV) as a foundation, the wider theoretical contribution of this thesis lies in the proposition that integrated solutions are constructed through the combination of platform strategy, project business and service innovation. A unique contribution is to consider the customer/user perspective, as the traditional literature on integrated solutions relies heavily on the supplier perspective. Another specific contribution is in the integration of two aspects of the platform strategy that are usually treated separately in the literature: (i) the reusability of components and subsystems; and (ii) the openness of the platform to external actors in order to drive innovation in the industry. The empirical evidence points to the development of the following approaches by BT: (i) the deployment of the network as a platform, integrating both aspects mentioned above; (ii) the adoption of a customer-centric approach which resulted in the establishment of a new business unit, BT Global Services (BTGS), that required the development of stronger capabilities in integrated solutions, especially in professional services (i.e. consultancy, project management and systems integration); (iii) the use of the term 'open innovation' as a management injunction within BT in order to coordinate several initiatives which bring together internal and external collaborators and resources to innovate in services. The above approaches, however, have not changed BT's core capability in the provision of network/infrastructure services. The challenge is to connect BT's platform to their customers' networks and to shape long-term relationships to enhance the profitability of the integrated solutions. Finally, the findings suggest that the platform and customercentric strategies may not be enough (or even be the right ones) for the survival and growth in the long-term future of BT in the telecommunications industry. This is evidenced by the recent failure (as of 2008) of BTGS to provide professional services profitably.


A divergent and expeditious access to haterumadienone- and puupehenone-type marine natural products has been achieved by using a newly developed hemiacetalization/dehydroxylation/hydroxylation/retro-hemiacetalization tandem reaction as one of the key steps. Its applicability is showcased by the first synthesis of haterumadienone, 20-hydroxyhaterumadienone, 20-epihydroxy-haterumadienone and 20-acetoxy-haterumadienone, as well as the facile synthesis of puupehenone, puupehedione and puupehenol. The synthesis is efficient, and atom- and step-economical (6 to 9 steps from commercially available starting materials), and requires no protecting groups and transition metals.


For the better part of the last century, the Supreme Court has held that courts must evaluate the voluntariness of juvenile confessions with "special care." This special care requirement cautions courts against judging juveniles "by the more exacting standards of maturity" or comparing a juvenile suspect "with an adult in full possession of his senses and knowledgeable of the consequences of his admissions." It also instructs courts to ensure that a juvenile's "admission was voluntary, in the sense not only that it was not coerced or suggested, but also that it was not the product of ignorance of rights or of adolescent fantasy, fright or despair." Despite the force with which the Supreme Court has spoken on the issue, lower courts regularly fail to follow the special care mandate. Some overlook the standard altogether, while others only pay lip service to it, and still others misconstrue it and disregard it on mistaken grounds. The result in any of these cases is that lower courts assess the voluntariness of juvenile confessions in the same way they would evaluate confessions obtained from adults, not with the heightened degree of scrutiny that Supreme Court precedent requires. In order to tether courts more firmly to the mast of special care, this Article highlights specific factors that courts should consider when evaluating the voluntariness of juvenile confessions. By framing their analyses in terms of these factors, courts can hopefully begin to evaluate juvenile confessions with the requisite level of care.


Study of the Utilization and Benefits of Phasor Measurement Units for Large Scale Power System State Estimation. (December 2005) Yeo Jun Yoon, B.S., Korea University, South Korea Chair of Advisory Committee: Dr. Ali Abur This thesis will investigate the impact of the use of the Phasor Measurement Units (PMU) on the state estimation problem. First, incorporation of the PMU measurements in a conventional state estimation program will be discussed. Then, the effect of adding PMU measurements on the state estimation solution accuracy will be studied. Bad data processing in the presence of PMU measurements will also be presented. Finally, a multiarea state estimation method will be developed. This method involves a two level estimation scheme, where the first level estimation is carried out by each area independently. The second level estimation is required in order to coordinate the solutions obtained by each area and also to detect and identify errors in the boundary measurements. The first objective of this thesis is to formulate the full weighted least square state estimation method using PMUs. The second objective is to derive the linear formulation of the state estimation problem when using only PMUs. The final objective is to formulate a two level multi-area state estimation scheme and illlustrate its performance via simulation examples.


Majority of the rural households in Kenya depend on agriculture as a source of food and livelihood. Agricultural productivity has been declining due to many factors resulting in increased food insecurity in the country. Consequently, there is a renewed interest in promoting drought-tolerant crops such as sorghum which thrives in the arid and semiarid lands of the developing world. However, performance of sorghum production among the smallholder farmers has still remained low. This study was thus carried out to identify factors that influence technical efficiency of sorghum production among smallholder farmers in Machakos and Makindu districts of the lower eastern Kenya. Collected data on farm and farmer characteristics were analysed by use of descriptive statistics and Tobit model. Result highlights show that technical efficiency was influenced positively by formal education level of the household, experience in sorghum farming, membership in farmers associations, use of hired labour, production advice, and use of manure. Surprisingly household size, meant to enhance labour, had a negative influence. To increase technical efficiency, efforts should focus on improving information flows on agronomic practices. Farmers should also be encouraged to form and actively participate in various farmers associations, which enhance learning and pooling of labour resources, hence improving technical efficiency.


The influx of Fortune 500 companies like IBM, Toyota and Starwood Hotels into the virtual world of Second Life has generated much publicity in 2006 and 2007. The virtual world landscape has changed substantially since. Many early adopters have abandoned virtual worlds, and the number of security-related incidents in virtual worlds has risen substantially. This paper discusses key security threats in virtual worlds, and highlights the need for users and stakeholders to better understand these threats in order to manage them more effectively. The issue of managing security threats in virtual worlds is especially important in ensuring that virtual worlds remain a friendly environment to thriving online communities and ebusiness; and represent an environment whereby the interests of various stakeholders are protected and upheld. The paper contributes to practice and research by (i) raising security awareness among virtual world users and stakeholders, and (ii) prescribing a systematic approach for analyzing the nature and implication of security threats in virtual worlds.


We model the 10 μm absorption spectra of nonspherical particles composed of amorphous silicate. We consider two classes of particles, compact ones and fractal aggregates composed of homogeneous spheres. For the compact particles we consider Gaussian random spheres with various degrees of non-sphericity. For the fractal aggregates we compute the absorption spectra for various fractal dimensions. The 10 μm spectra are computed for ensembles of these particles in random orientation using the well-known Discrete Dipole Approximation. We compare our results to spectra obtained when using volume equivalent homogeneous spheres and to those computed using a porous sphere approximation. We conclude that, in general, nonspherical particles show a spectral signature that is similar to that of homogeneous spheres with a smaller material volume. This effect is overestimated when approximating the particles by porous spheres with the same volume filling fraction. For aggregates with fractal dimensions typically predicted for cosmic dust, we show that the spectral signature characteristic of very small homogeneous spheres (with a volume equivalent radius r_V≲ 0.5 μm) can be detected even in very large particles. We conclude that particle sizes are underestimated when using homogeneous spheres to model the emission spectra of astronomical sources. In contrast, the particle sizes are severely overestimated when using equivalent porous spheres to fit observations of 10 μm silicate emission.


Introduction Nasopharyngeal carcinoma (NPC) is among the most common head and neck malignancies seen among adults in Malaysia. It is the third most common cancer in males after colorectal and lung cancers. Even though it has bimodal peak distribution, young NPC is a rare occurrence. It accounts for less than 1% of all paediatric cancers. Objective The objective of this study was to describe the 8-year experience with young NPC in the year 2003 until 2010 in a tertiary centre in East Coast Malaysia Hospital. Method Twenty-four young NPC cases confirmed by histopathology and undergoing treatment in a tertiary centre in East Coast Malaysia Hospital between 2003 and 2010 were retrospectively reviewed. We studied NPC incidence observed during that period, focusing on the age and sex distribution and the ethnic background of patients. We also analysed the most prevalent signs and symptoms and staging of the NPC patients at first presentation, which include neck swelling, ear symptoms, nasal symptoms and other miscellaneous symptoms. Results Presentation was predominant in the Malay population, with age peaking between 16 and 20 years. Most patients were male (70.8%). The main presenting symptoms were neck mass (70.9%), unilateral nasal obstruction (33.3%), epistaxis (29.2%) and other miscellaneous complaints (20.9%), including headache, diplopia and facial paraesthesia. In all, 25% of patients had cranial nerve involvements either isolated or a combination of cranial nerves 2, 3, 4, 5, or 6. Stage I, II, III and IV patients accounted for 0, 4.2, 12.5 and 83.3%, respectively. Majority (91.7%) had WHO type 3 NPC (undifferentiated carcinoma). Conclusion Results from our series are comparable to those reported by other centres. A majority of the patients were diagnosed late and at the advanced stage. The TMN staging was a relevant prognostic factor.


The chromosome complement of a bathypelagic myodocopid ostracod, Gigantocypris muelleri Skogsberg, 1920, is described. The karyotype of this bisexual species consists of 2n = 18 (16A + XX) for the female and 2n = 17 (16A + XO) for the male. These chromosomes are all metacentric and of very similar size, ranging from 19μm to 24μm. This is the first description of the karyotype of a marine ostracod.


We review the empirical literature that estimates the causal effect of parent's schooling on child's schooling, and conclude that estimates differ across studies. We then consider three explanations for why this is: (a) idiosyncratic differences in data sets; (b) differences in remaining biases between different identification strategies; and (c) differences across identification strategies in their ability to make out-of-sample predictions. We conclude that discrepancies in past studies can be explained by violations of identifying assumptions. Our reading of past evidence, together with an application to Swedish register data, suggests that intergenerational schooling associations are largely driven by selection. Parental schooling constitutes a large part of the parental nurture effect, but as a whole does not play a large role.


It is well-established that a high incidence of p53 mutations exist in oral cavity squamous cell carcinomas (OCSCCs). To determine whether p53 mutations are etiologically associated with OCSCC development or are associated with exposure to specific carcinogens, we have analyzed the conserved regions of the p53 gene (exons 5-9) in 48 OCSCCs obtained from patients with varied tobacco and alcohol use histories by polymerase chain reaction/single strand conformational polymorphism (PCR/SSCP) and DNA sequencing analysis. Thirty-eight percent (18/48) of the OCSCCs exhibited a mutation in exons 5-9 of the p53 gene. There was a significantly higher incidence of p53 mutations in OCSCCs from tobacco users (predominantly cigarette smokers) compared to those who had never used tobacco. No increase in the incidence of p53 mutation was observed in tobacco users who drank alcohol. G to A transitions and deletions were the predominant mutations observed in OCSCCs from tobacco users. No specific pattern of mutation was observed in OCSCCs from those subjects who had never used tobacco. These data suggest that a history of tobacco use was associated with a high incidence of p53 mutations in patients with OCSCC and that tobacco carcinogens include a specific pattern of mutations in oral cavity tissue in vivo.


Gaining a driver's licence represents increased independence and can lead to improved quality of life for individuals and their families. Learning to drive a motor vehicle and maintaining safe on-road skills are often more difficult for people on the autism spectrum. Many countries currently have no autism-specific licencing requirements for learner drivers, and there is a general lack of ASD-specific support and training packages for individuals, their families, and driving instructors. This review synthesises the peer-reviewed literature about the driving characteristics of drivers on the spectrum and driver training available for the cohort. The evidence in this review showed that individuals on the autism spectrum drive differently from their neurotypical counterparts. There are shortcomings in tactical skills of drivers on the autism spectrum, but the extent to which this affects their own safety or the safety of other road users is unclear. Tactical skills can be improved through training programs. There are few autism spectrum-specific learner training programs available. Development of an effective training program will benefit individuals on the spectrum to learn to drive, be independent, and be safe on the road.


PURPOSE
To study whether endarterectomy is feasible in all patients with aortofemoral atherosclerotic obstruction, considering early and late results.

METHODS
A clinical, prospective, and descriptive study carried out in a university hospital. Inclusion criteria were atherosclerotic aortofemoral obstructive disease, clinical status compatible with major surgery, and absence of prior restorative procedure. Exclusion criteria were aneurysm, inflammatory arterial disease, and prior restorative procedure found during surgery. Eighty patients entered the protocol, but 9 were excluded (11.2%). Seventy-one patients, mean age of 57.3 years, underwent endarterectomy. Operative indications were intermittent claudication and critical ischemia. A ring-stripper endarterectomy technique was employed in all patients. Results were related to age, gender, symptoms, presence of diabetes mellitus, extension of endarterectomy, and extent of obstructive disease. Chi square or Fisher exact tests were used when appropriate, and the Wilkoxon (Gehan) test was used to compare survival curves.

RESULTS
Sixty-eight (100%) endarterectomies were patent at discharge. The mortality rate was 4.2%. The amputation rate (4.3%) was higher in diabetic patients and when there was associated femoropopliteal obstruction. The 5-year survival rate was 83.3%, and late deaths were mostly cardiovascular. Diabetes mellitus, age above 65 years, and associated femoropopliteal obstruction lowered the survival rate. The 5-year patency rate was 87.0%. Critical ischemia and less extensive endarterectomies were associated with a lower patency rate. There were no anastomotic aneurysms or deep infections.

CONCLUSIONS
Aortofemoral thromboendarterectomy is feasible in 90% of patients, early mortality rate is low, diabetic patients and those with associated femoropopliteal obstructive disease have a higher mortality rate, amputation rate is low, late deaths are mostly cardiovascular, and late patency rate is high, and even higher in the intermittent claudication group.


In the Canadian high Arctic, subsistence hunters and fishers have learned, over generations, to construct shelters from available materials so they can survive inclement weather while harvesting food. Now, as accelerating climate change exacerbates the intensity and unpredictability of extreme weather, scientists and country food harvesters once again worry about becoming stranded. To envision how tradition-based dwellings might serve as modern short-term survival/emergency structures, we reconstructed four vernacular structures in largelyIndigenous Arctic communities and compared them with a Sami reconstruction from Arctic Scandinavia. Local knowledge-holders and students participated and proposed adaptations using modern materials and concepts. The five structures were qualitatively evaluated for replicability, adaptability to modern situations, on-going usefulness, thermal performance, and materials availability. Quantitative evaluations included speed of construction relative to length of use and approximate mass of structure per person. The structures that were most adaptable, replicable, and efficient were elliptic paraboloid-shaped dwellings: Inuvialuit willow-framed moss-and-skin-clad dwellings (Western Canadian Arctic), Inuinnaqtun snow houses (iglus and qarmaqs) (central Canadian high Arctic), and birch-framed turf-clad homes (Scandinavian Arctic). All shared the following characteristics: (1) catenaryor elliptic paraboloid-domed framework, (2) materials accessed from immediate vicinity of building site, (3) ease of construction by 1 or few people, (4) passive heating and insulated assemblies, (5) windbreaks incorporated into siting and design, (6) strong structure resistant to high winds and inclement weather, and (7) siting along routes where foods are harvested. These characteristics are now serving as design principles for temporary Arctic dwellings, demonstrating how recording, adapting, and sharing long-resident peoples' architectural knowledge facilitates survival during extreme events associated with accelerated climate change.


In the past ten years, polymerizeable amphiphiles have been recognized as an important class of synthetic phospholipids due to their ability to modify the mechanical and chemical stability of membranes. The motivation behind studies of polymerizeable phospholipids is based on the potential importance of stable membranes in a wide variety of applications including reactivity control, encapsulation technologies and drug delivery. However, compared to nonpolymerizeable lipids, there is a relative paucity of information correlating membrane physical properties with the structure of the polymeric lipid. The present investigation involves the synthesis of a series of disulfide polymerizeable phosphatidylcholines, the characterization of the physical properties of membranes formed from these lipids, and an investigation of the biodistributions, vascular clearance rates and degradation rates of these liposomes in vivo. The structures of the lipids under investigation are analogous to saturated phosphayitdylcholines but with a thiol either alpha to the carbonyl of the acyl chain (α-THIOL) or at the chain terminus (ω-THIOL). It is found that the presence and position of the polymerizeable moiety drastically alters the physical characteristics of the membranes. A variety of physical techniques have been utilized to understand both the bulk properties of the lipids such as morphology and permeability, as well as the molecular details of the lipid conformation and dynamics. On the basis of such studies including Raman, FT-IR and DSC, it appears that the presence of the polymerizeable group at the interfacial region (α-THIOLS) causes a reduction in the lipid packing and an increase in chain disorder compared to nonpolymerizeable analogs. For the monomeric form of the α-THIOLS, the decreased interlipid interaction may be ascribed to the presence of an additional hydrophilic pendant group at the interface that interferes with tight crystalline packing, most likely by a combination of steric and hydration effects. In contrast to the general expectations for polymerized versus nonpolymerized phospholipids, upon polymerization, the membrane disorder is augmented even further. We believe this to be a consequence of the conformational restrictions of polymerization which inhibit the ability of the polymeric lipids to adopt a highly ordered and uniform packing state. Instead it is suspected that the reduced conformational freedom of polymerized lipids promotes the formation of surface defects between unlinked polymer chains. As a morphological consequence, the polymeric α-THIOLS tend to form smaller and largely unilamellar vesicles on dispersion in water. Furthermore because of the disorder in the hydrocarbon chain region, they are quite permeable to entrapped solutes and when administered in vivo, are cleared rapidly from the circulatory system. The latter effect is likely the result of facilitated absorption of opsonizing proteins into the disordered membrane surface which subsequently accelerates vascular clearance and uptake by the cells of the reticuloendothelial system (RES). On the basis ³¹P NMR relaxation measurements, it was observed that the motion of the headgroups in polymeric α-THIOLS was reduced relative to nonpolymerizeable analogs. Furthermore a reduced chemical shift anisotropy of polymeric α-THIOLS in the liquid-crystalline state relative to nonpolymerizeable lipids was observed and suggests an alteration in the average orientation of the headgroup for the polymer. Because the headgroup of phosphatidylcholines is zwitterionic, changes in the average orientation can have marked effects on the electrostatic properties of the membrane surface, which in turn can affect membrane morphology and interactions with cell-surfaces and proteins. For ω-THIOLS, a distinctly different behavior was observed compared to the α-THIOLS. For the monomers and especially the polymers, results from vibrational spectroscopy and DSC suggest that the membrane conformational order and rigidity is increased relative to nonpolymerizeable phosphatidylcholine analogues. However, in contrast to the α-THIOLS that form normal self-sealed liposomal structures in both the monomeric and polymeric state, polymerization induces the transformation of ω-THIOLS into bilayer fragments lacking an internal aqueous compartment. The most likely explanation for this was derived from ¹³C NMR relaxation experiments, which indicated that the mobility at the bilayer midplane of polymeric ω-THIOLS is as restricted as the interfacial region. This contrasts to nonpolymerizeable phospholipids and α-THIOLS, which have the bilayer interior as the most fluid portion of the membrane. The rigidity at the midplane may prohibit the ability of the polymeric ω-THIOLS to form curved or continuous multilamellar sheets or to respond to transient defects in the membrane without fragmentation. An interesting and unexpected result concerning the ω-THIOLS was retention of a phase transition after polymerization. For most polymeric lipids that have the polymerizeable moiety at the chain terminus, polymerization has resulted in the disappearance of the transition due to crosslinking of the hydrocarbon chains. The presence of the transition in polymerized ω-THIOLS may be evidence for the fact that polymerization results in a predominance of intra- rather than inter-leaflet coupled chains.


Current processes in international theatre practice have been so different in artistic sense that they could hardly be combined in some unity. But there is anothercriterion, not purely artistic, according to which artistically different phenomena of contemporary theatre could be united in wholeness. It is an institutional kind of criterion. Contemporary state of theatre as a kind of art could not be clearly described and then productively investigated without interpretation of those strong and deep transformations that have happened to theatre as a kind of societal institution. The thing is that researchers usually do observe artistic and societal qualities of art separately. Of course, it is one of the results of knowledge coming into depth and getting specialized, but sometimes it seems as if in development of art there were two divided processes – artistic, on the one hand, and societal, on the other hand. In reality, this development is one and whole total process with many various aspects. To keep in mind the unity of artistic and societal transformations of theatrical art is the challenge for methodological discourse within any aesthetic investigation in this field. Institutional theory of art, according to the author's point of view, is the very case of methodological attitude that allows a researcher stay realistic in relation to the abovementioned unity. There is the key point that demonstrates it – the approach of the institutional theory of art to the problem of psychical distance between performance and spectators, its historical institutionalization in the phenomenon of classical and the following changes within this institutional state that finally brought theatre from classical to non-classical aesthetic regime. Institutional theory looks at this transition as artistic in the inspiriting causes, but societal is focused on fixation of their results. So, this theory allows an aesthetic observer keep the balance on the blade of the artistic and the societal contents of the institutional state of contemporary theatre. This article is the author's attempt to point out the most significant institutional changes in contemporary theatre.


Aim:  This study compared the diets of breastfeeding and non-breastfeeding mothers from socioeconomically diverse regions of Melbourne to determine whether breastfeeding is a marker for healthier maternal dietary intakes.

Methods:  This cross-sectional study obtained information via self-reported questionnaire from 529 first-time Melbourne mothers. Breastfeeding status was determined when the children were 3.9 months. Diet information was obtained using a validated Food Frequency Questionnaire. Maternal diet was assessed by seven indicators: average daily intake of fruit, vegetables, non-core drinks, non-core sweet snacks, non-core savoury snacks, variety of fruit and variety of vegetables eaten in the preceding 12 months. Associations between breastfeeding status and each dietary variable were assessed using linear regression analyses. Socioeconomic position, maternal body mass index and the cluster-based sampling design were controlled for.

Results:  Of the 529 subjects, 70% were breastfeeding their child. Compared with non-breastfeeding mothers, breastfeeding mothers were found to consume more serves of vegetables (P= 0.001), a greater variety of fruit and vegetables (P= 0.001 and P≤ 0.001 respectively), and sweet snacks were consumed more frequently (P= 0.006). Differences were observed between low and high socioeconomic position mothers for fruit serves (P= 0.003), vegetable serves (P= 0.010) and fruit variety (P= 0.006). These associations persisted after controlling for socioeconomic position and maternal body mass index.

Conclusions:  The association between infant feeding (breastfeeding) and some aspects of maternal diet provides further evidence suggesting a link between maternal and child diets from a younger age than previously examined.


Abstract:If democracy still reigns supreme in contemporary political discourse, why is it in crisis? Popular willingness to trade off democratic principles for instrumental gains offers a critical lens to examine this crisis. Data from the Global Barometer Surveys II and a U.S. national survey covering societies show that while Asian and North African respondents are most likely to trade democratic principles for instrumental gains, U.S. and Latin American respondents are least likely to do so, and sub-Saharan Africans fall in the middle. These results provide comfort that publics in many democracies prioritize democratic principles above all. But they also show that majorities in many authoritarian societies do not.


Experimentation has been the center of a fascinating debate among entrepreneurship practitioners throughout the past decade. While intellectually stimulating and practically relevant, this discussion has received little attention from management research, and therefore has no scientific support. To start filling this gap, I propose a novel theory of experimentation in entrepreneurial ventures. I argue that the impact of experimentation on performance is highly contingent on market-level and organization-level factors. This theoretical exercise seeks to shed light on when experimentation creates value and when it destroys value. By using the value-based strategy approach, I propose that experimentation drives short-run value through the channels of learning, reputation, and imitation, and affects long-run value through the channels of imprinting and positioning. I conclude by listing a set of testable implications for future empirical analysis.


3 INTRODUCTION 4 METHODS 8 RESULTS 10 CONCLUSION 19 ACKNOWLEDGEMENTS 22 RESEARCH FUNDING 22 REFERENCES 23 CYCLING INFRASTRUCTURE & CYCLING ACTIVITY Gilroy 3 ABSTRACT Over the last decade, the City of Salem, Massachusetts has made significant investments in infrastructure to support cycling in the City, such as the construction of new bike lanes and cycle paths. To what extent do these investments meet the actual activities and needs of cyclists? What routes do cyclists commonly use? To better understand cyclists' usage of roads in the City of Salem, this research will analyze user-populated information from Strava, a mobile application that records a user's coordinates as they cycle through Salem. Geographic Information Systems (GIS) will be used to analyze and create maps that highlight the aggregate habits of cyclists in Salem and compare those to cycling infrastructure, and public safety. This information can be used to help guide cycling growth and investment in the City of Salem. The research and analysis is valuable for demonstrating the true impact and usage of cyclists on roads in Salem.


The relationship between athletic trainers (ATs) and physicians is crucial for the continuity of care for patients and can impact the advancement of the athletic training profession. This descriptive study utilized a questionnaire to examine the level of competence physicians believe ATs possess to perform tasks within their scope of practice, as outlined in theRole Delineation Study, 6th ed. Overall, physicians had favorable perceptions of ATs' competence, with the most favorable perceptions relating to injury/illness prevention and immediate and emergency care. Opportunities should be sought out by ATs to educate physicians on all domains of athletic training practice. Future research should examine how these perceptions may change as athletic training education requirements change.


We demonstrate an efficient phase-retrieval method, allowing the recovery of features of dynamic objects that are sparsely varying--i.e. when the difference between two consecutive frames is small. The method uses redundancy in information between similar consecutive frames to recover the features more robustly than current phase-retrieval methods, and necessitates a considerably smaller number of measurements. Both of these features directly lead to shorter acquisition time, paving the way to coherent diffractive imaging of fast dynamic processes. Numerical simulations show a possible 100-fold improvement in temporal resolution over existing methods.


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Consanguineous marriage--marriage between relatives--has received a great deal of attention as a potential risk factor for many adverse health outcomes. The present cross-sectional study was done in order to illustrate the prevalence and types of consanguineous marriages among Iranian Georgians living in Frydoonshahr (Isfahan province, central Iran). Data on consanguineous marriages were collected using a simple questionnaire. The total number of couples in this study was 646. Consanguineous marriage was classified by the degree of relationship between couples. First cousin marriages (14.2%) were the most common type of consanguineous marriages, followed by second cousin (7.0%), beyond second cousin (1.5%) and first cousin once removed (0.6%). The mean inbreeding coefficient (α) was calculated as 0.0104 for the population. The present study shows that the study population, as other Iranian populations, has a high level of consanguinity.


In the concordance LCDM cosmological model, galaxies form in the centers of dark matter halos and merge with one another following the mergers of their host halos. Thus, we set out to quantify the growth mechanisms of dark matter halos. For this purpose, we analyze several large N-body simulations of the growth of cosmic structure. We devise a novel merger tree construction algorithm that properly takes into account halo fragmentations. We find that the merger rate evolves rapidly with redshift but depends weakly on mass, and that the proportions between mergers of different mass ratios, e.g. major and minor mergers, are universal. We also show that the merger rate per progenitor halo (related to future mergers and to galaxy pair counting) is smaller than that per descendant halo (related to past mergers and galaxy disturbed morphplogies), and that their redshift and mass dependencies are different. We find that only ~60% of the mass accreted onto halos arrives in mergers that are resolved in our simulations. Moreover, the functional form of the merger rate suggests that the merger contribution saturates at that value. Using full particle histories, we confirm that smoothly-accreted particles make a significant fraction of dark matter halos. This has important implications for the smoothness of gas accretion.

Disk galaxies at z~2 are rapidly star-forming, but show regular rotation, indicating little merger activity. We use a large dark matter simulation to show that even non-merging z~2 halos grow fast enough to explain observed high star-formation rates. We also follow those halos to z=0, finding that many do not undergo major mergers at all. The z~2 disks also show high velocity dispersions and irregular clumpy morphologies. We run "zoom-in" cosmological hydrodynamical simulations focusing on the formation of individual z~2 galaxies. We find that the clumpy morphologies are a result of gravitational instability, where the high random motions make the (turbulent) Jeans scales as large as the observed giant clumps. Star-formation feedback in our model is implemented as galactic winds with high mass-loading factors. We find that the high mass-loading factors prevent the clumps from virializing. Within roughly half a disk orbital time, they lose a large fraction of their mass, such that they stop collapsing and disrupt. Thus, their lifetimes are short and they do not migrate to the galaxy centers as has been proposed in the literature so far. We compare simulated galaxies to observations using radiative transfer calculations, and by creating mock SINFONI/VLT data cubes with realistic "observing conditions". We find good agreement between "observed" simulated galaxies and real observed ones, in terms of their luminosities, colors, morphologies and kinematics. With this comparison, we conclude that the galaxies formed in our simulations are plausibly realistic.


This paper builds on previous research by offering new perspectives on the importance of spontaneous speech innovation in linguistic, social, and cultural processes of language contact and change in Spanish-speaking communities of Spain and America. The author reconsiders existing data concerning such innovation and synthesizes previous independent findings in a novel, unified approach that relates previously unrelated but functionally similar linguistic phenomena. With the purpose of moving toward a more comprehensive and verifiable model of language contact and change, the paper underlines some complex linguistic and extralinguistic functions associated with spontaneous speech innovations in contact varieties and outlines a coordinated program of interdisciplinary sociolinguistic research to establish appropriate archival tools for documenting corpus-based spontaneous speech innovations for posterior analysis.