Background. Over the last decade, Thailand has experienced an aging population, especially in rural areas. Research finds a strong, positive relationship between good quality housing and health, and this paper assesses the impact and living experience of housing of older people in rural Thailand. Methods. This was a mixed-method study, using data from observations of the physical adequacy of housing, semistructured interviews with key informants, and archival information from health records for 13 households in rural Thailand. Results. There were four main themes, each of which led to health risks for the older people: "lighting and unsafe wires," "house design and composition," "maintenance of the house," and "health care equipment." The housing was not appropriately designed to accommodate health care equipment or to fully support individual daily activities of older people. Numerous accidents occurred as a direct result of inadequate housing and the majority of houses had insufficient and unsafe lighting, floor surfaces and furniture that created health risks, and toilets or beds that were at an unsuitable height for older people. Conclusion. This paper provides an improved and an important understanding of the housing situation among older people living in rural areas in Thailand.


"Leaderless resistance" and "lone wolf terrorism" are concepts that have steadily gained importance in the study of oppositional subcultures and terrorist groups, being used to describe the operational realities of a variety of terrorisms, from groups like Al Qaeda to Anders Breivik. In this article, I seek to describe leaderless resistance as a rhetorical construct, a meaning-conferring "ideology of effervescence" that lifts the spirits of both movement progenitors who advocate the strategy as well as incipient lone wolves who consider responding to their exhortations. Through an examination of the case of Wiebo Ludwig and the EnCana pipeline bombings of 2008–2009, I show how these rhetorics emerge in the interactions between activists and their political enemies. With this conception, we can (a) understand more fully the discursive/rhetorical dynamics involved in asymmetrical struggle, (b) problematize the acceptance of the organizational reality of leaderless resistance in the terrorism literature, and (c) question the assertion of some terrorism scholarship that refers to leaderless resistance and other ideologies of effervescence as hallmarks of the "new terrorism."


We describe the evaluation of a personal digital library environment designed to help musicians capture, enrich and store their ideas using a spatial hypermedia paradigm. The target user group is musicians who primarily use audio and text for composition and arrangement, rather than with formal music notation. Using the principle of user-centered design, the software implementation was guided by a diary study involving nine musicians which suggested five requirements for the software to support: capturing, overdubbing, developing, storing, and organizing. Moreover, the underlying spatial data-model was exploited to give raw audio compositions a hierarchical structure, and - to aid musicians in retrieving previous ideas - a search facility is available to support both query by humming and text-based queries. A user evaluation of the completed design with eleven subjects indicated that musicians, in general, would find the hypermedia environment useful for capturing and managing their moments of musical creativity and exploration. More specifically they would make use of the query by humming facility and the hierarchical track organization, but not the overdubbing facility as implemented.


Cities across the world have had to diversify and expand their water supply systems in response to demand growth, groundwater depletion and pollution, and instability and inadequacy of regional surface freshwater sources. In the U.S., these problems plague not only the arid Western cities but increasingly also cities in the Eastern portions of the country. Although cities continue to seek out new sources of water via Promethean projects of long‐distance supply systems, desalinization plants, and the recharge of aquifers with surface water, they also pursue water conservation because of its low cost and other benefits. We examine water conservation as a complex sociotechnical system comprising interactions of political, sociodemographic, economic, and hydroclimatological factors. We provide quantitative data on the factors that affect more and less advanced transitions in water conservation regimes, and we show that water stress and other hydrological data can only partially predict the transition. We also provide qualitative case studies to identify institutional and political barriers to more advanced water conservation regimes. This interdisciplinary, mixed methods approach typifies the need for knowledge that informs hydrologists about how their research may or may not be adopted by decision‐makers.


Pulse-amplitude modulated fluorometry (PAM) was evaluated for monitoring the physiological condition of the seagrass, Thalassia testudinum, in Florida Bay. This approach is attractive because it is rapid, non-invasive, and offers quantitative physiological information. Yet, problems arise when expanding sampling from the organismal scale to the landscape scale, due to temporal changes in photophysiology. The magnitude of diurnal variation of photosynthetic characteristics was investigated using Rapid Light Curves (RLC), which measure quantum yield over a range of changing actinic irradiances. In this study, the resulting calculated parameters (alpha and ETRmax) significantly changed diurnally, as was previously found with effective quantum yield. The significance of among basin and year comparisons was also confounded by diurnal variation and rigorous statistical analysis was unable to discern which time of day was best suited for assessing the photophysiological status of T. testudinum. Even though measurements taken with PAM fluorometry exhibited a significant amount of diurnal noise, informative physiological patterns did emerge. The ability to distinguish among basins and see landscape scale trends within the bay gives us an indication that PAM fluorometry may be useful as a monitoring tool. However, in ecosystems where the magnitude of changes are large and occur on much faster timescales than the ecosystem changes that you are trying to measure, the resulting fluctuations may obscure the true physiological signal. Therefore, when using this approach over large spatial and temporal scales diurnal variability must be considered.
In order to incorporate the entire temporal and spatial scale two previously proposed methods, the Diel Yield and Diel Rapid Light Curve method, were investigated. Photosynthesis irradiance (P-E) curves were calculating using both methods and the ability of each method to accurately predict the relationship between electron transport and irradiance was explored. It was found that neither method was able to provide consistent estimates of photosynthetic efficiency or capacity. The Diel Yield method frequently produced unrealistic predictions of photosynthetic capacity (rETRmax) and saturation irradiance (Ik). The Diel RLC method produced more reasonable predictions of rETRmax and Ik, but this method had the most difficulty predicting photosynthetic efficiency (alpha) when ambient irradiances were continuously high throughout the day (>Ik). With some further calculations we believe the Diel RLC method can provide an estimate of photosynthetic efficiency and offer a way to reasonably approximate landscape-level photosynthetic characteristics. Because both methods investigated in this study use data generated from RLCs, which have been shown to vary depending on previous light history; diurnal variations do affect estimates of electron transport rates. Therefore, the Diel RLC method does not negate diurnal variation but it does produce a curve that incorporates the changing ambient light environment.


Non-cooperative game theory is at its heart a theory of cognition, specifically a theory of how decisions are made. Game theory's leverage is that we can design different payoffs, settings, player arrays, action possibilities, and information structures, and that these differences lead to different strategies, outcomes, and equilibria. It is well-known that, in experimental settings, people do not adopt the predicted strategies, outcomes, and equilibria. The standard response to this mismatch of prediction and observation is to add various psychological axioms to the game-theoretic framework. Regardless of the differing specific proposals and results, game theory uniformly makes certain cognitive assumptions that seem rarely to be acknowledged, much less interrogated. Indeed, it is not widely understood that game theory is essentially a cognitive theory. Here, we interrogate those cognitive assumptions. We do more than reject specific predictions from specific games. More broadly, we reject the underlying cognitive model implicitly assumed by game theory.


Automatic unreliable news detection is a research problem with great potential impact. Recently, several papers have shown promising results on large-scale news datasets with models that only use the article itself without resorting to any fact-checking mechanism or retrieving any supporting evidence. In this work, we take a closer look at these datasets. While they all provide valuable resources for future research, we observe a number of problems that may lead to results that do not generalize in more realistic settings. Specifically, we show that selection bias during data collection leads to undesired artifacts in the datasets. In addition, while most systems train and predict at the level of individual articles, overlapping article sources in the training and evaluation data can provide a strong confounding factor that models can exploit. In the presence of this confounding factor, the models can achieve good performance by directly memorizing the site-label mapping instead of modeling the real task of unreliable news detection. We observed a significant drop (>10%) in accuracy for all models tested in a clean split with no train/test source overlap. Using the observations and experimental results, we provide practical suggestions on how to create more reliable datasets for the unreliable news detection task. We suggest future dataset creation include a simple model as a difficulty/bias probe and future model development use a clean non-overlapping site and date split.


The objectives are to examine rural road accident data in order to develop a method by which high accident rate locations and accident causes can be identified, and also to develop proposals for improvements at such locations and to identify measures which will improve road safety throughout the country. The problem of road safety in Iran is an important issue, because of the tragic and unnecessary loss of life, and the enormous cost of accidents in the country. The resources available to deal with the problems are limited and must be allocated on priority basis. This study represents an initial effort to identify the extent of the problem in order to take remedial measures. A study was made of all the available road accident data collected by agencies related to road safety in Iran, and the major organisations responsible for road safety development were visited. The Vice Minister of Roads and Transportation selected for this study a 280 Km rural road in South West Iran. Mainly because of the lack of suitable maps and plans of the roads, it was not possible to accurately identify the location of accidents. Accident scene data was subsequently collected by the highway police and personally by the author. The data for the study road was then analysed to identify 'high accident rate' locations, and also to determine, as far as was possible, the reasons for the accidents. The study suggests specific improvements for each of the high accident rate locations examined (eg. the building of dual carriageways with central guard rails to reduce the risk of collision with oncoming vehicles, pedestrian facilities to allow pedestrians to cross dangerous roadsl]. In addition recommendations are made to guide and assist the major organisations responsible for road safety in Iran. These recommendations are: (al for improving accident data collection and storage (bl for subsequent analysis for taking remedial measures with a view to accident prevention


New thermally reactive copolymers based on dithienylthiazolo[5,4-d]thiazole (DTZ) and silolodithiophene (SDT) have been synthesized and explored in bulk heterojunction solar cells as mixtures with [6,6]-phenyl-C61-butyric acid methyl ester (PCBM). In thin films the polymers had optical band gaps in the range of 1.64–1.80 eV. For solubility the polymers have incorporated alkyl groups on the SDT unit and thermally removable ester groups on the DTZ unit that can be eliminated around 200 °C for improved photochemical stability in thin films. The bulkiness of the alkyl chains on the SDT unit proved to be very significant in terms of photovoltaic performance of the polymer:PCBM solar cells. Polymers based on 4,4-dihexyl-4H-silolo[3,2-b:4,5-b′]dithiophene reached power conversion efficiencies (PCEs) up to 1.45% but changing the alkyl groups to more bulky ethylhexyl chains reduced the PCE to 1.17%. More noteworthy is that the photovoltaic performance improves for the polymers based on 4,4-dihexyl-4H-silolo[3,2-b:4,5-b′]dithiophene after the ester groups has been eliminated from the DTZ unit by a thermal treatment around 200 °C. To confirm that elimination of the solubilizing groups improve the long term durability of the materials the photochemical stability was estimated by a novel accelerated degradation method by which the photobleaching of the polymer was followed during degradation at 100 solar intensities. This clearly shows that the pristine polymer films are by far the most unstable under the given conditions emphasizing the unfavorable effect of solubilizing groups on the photochemical stability of conjugated polymers.


A1689 is a galaxy cluster at z = 0.183 for which previous measurements of its mass by using various techniques gave discrepant results. We present a new detailed measurement of the mass with the data based on X-ray observations with the European Photon Imaging Camera aboard the XMM-Newton Observatory, determined by using an unparameterized deprojection technique. Fitting the total mass profile to a Navarro-Frenk-White model yields halo concentration c = 7.2 and r200 = 1.13 ± 0.21 h-1 Mpc, corresponding to a mass that is less than half of that found from gravitational lensing. Adding to the evidence of substructure from optical observations, X-ray analysis shows a highly asymmetric temperature profile and a nonuniform redshift distribution, implying large-scale relative motion of the gas. A lower than expected gas mass fraction fgas = 0.072 ± 0.008 (for a flat ΛCDM cosmology) suggests a complex spatial and/or dynamical structure. We also find no sign of any additional absorbing component previously reported on the basis of the Chandra data, confirming the XMM-Newton low-energy response by using data from ROSAT.


With the rise of the various intellectual streams in the Western world in the second half of the twentieth century, modern Arab poets recognized the need to promote the Arabic poem. They knew that the road of self exploration and promotion begins in the ancestral legacy. "The Road to Self-Revival" explores the tendency of modern Arabic poetry to summon Sufi figures, thinking, philosophy, terms, attitudes and practices. Specifically, this volume focuses on the poetry of four Arab modernists: Abdul Wahab al-Bayyati (1926-1999), Ali Ahmad Said known as Adonis (1930), Salah Abdu-s-Sabur (1931-1981) and Mahmud Darwish (1941-2008). The book traces a number of Sufi figures in the poetry of these poets: Bishr ibnul-Harith Al-Hafi (767-840), Al-Husain Ben Mansur Al-Hallaj (858-922), Farid ed-Din Al-'Attar (1145/46-1221), Muhyi ed-Din bnul-'Arabi (1165-1240) and Jalal ad-Din Mohammad Rumi (1207-1273).


This thesis presents a contemporary approach to the problem of the lack of recognition of women in Australian society and politics using the Australian Labor Party (ALP) as background and the Victorian Branch of the Australian Labor Party as a test case. It examines the paradox that women have had the vote in Australia for over a hundred years yet, in the largest political party officially dedicated to social equality, they still fail to hold leadership positions with the exception of Jenny Macklin who is Deputy Leader of the Federal Parliamentary Labor Party (FPLP). Several writers have drawn attention to this puzzle of the lack of effective participation in general by women in Australian political life. Authors such as Joy Damousi, Anne Henderson, Marian Sawer and Marian Simms among others have begun the process of theoretical and historical analysis of women in politics in this country. Sawer and Simms are both prominent female academics in the field of Political Science. Their book, A Woman's Place: Women and Politics in Australia (1993), is a good example of an emerging genre. Given my own particular academic interests, the thesis is based in the discipline of Political Science. It is not located primarily in the area of Women's Studies, but feminist theories and ideas are applied, as are historical surveys and sociological perspectives to support my arguments and buttress conclusions. The aim of the work is to examine the Victorian Branch of the ALP between 1946 and 2005 and tests the hypothesis that a combination of societal and structural factors has been responsible for the exclusion of women for the most part from leadership positions in the Party. The Victorian Branch was chosen partly for reasons of access and manageable size, but also because it is representative of general trends in Australian politics. Essentially, this thesis is about the role of women in a major political party committed to the cause of working-class people. It does not deal with policy formulation or the dynamics of the parliamentary arena. Rather, it concentrates on the party's culture and the structural and organisational factors which affect the participation rates and levels of influence of women. This thesis will contribute to knowledge by analysing the reasons for the exclusion of women from positions of power in the Victorian Branch of the ALP; it also draws lessons about the nature of politics in Australia. Indeed, it constitutes the first major study of the role of women in Victorian ALP politics—no such study currently exists. My own personal case studies will determine how and why and if male-dominated 'traditions' (patriarchy) are restricting the progress of women in the public sphere in this country. The research material from interviews with past and present female MPs (including former Victorian Premier Joan Kirner) and State Executive members will provide a great deal of invaluable information and opinion for other students of party politics. The thesis will give an opportunity for female ALP views to be expressed. A further contribution to knowledge will be to establish why injustices, inequalities and constraints have been placed on women which hinder their rise to power in the ALP and the Victorian Branch. It is significant to state that throughout Australia's largely patriarchal history the nonrecognition, or misrecognition, of Australian women has been a form of exclusion resulting in their under- representation in leadership roles in the ALP and its Victorian Branch. Therefore, by studying the particular processes of how gender diversities are formed within a historical and ideological context, we can start to hypothesis on how and why women have been marginalised with the male-dominated ALP and the Victorian Branch. This thesis will examine why women in the Victorian Branch of the ALP have been largely excluded from decision-making positions. Has a combination of cultural, historical, sociological and structural reasons contributed to their exclusion until some thirty years ago when things began to appear to change? Are attempts to make the Branch more inclusive real or are they simply a form of Marcusian repressive tolerance? Therefore, in order to clarify specific aims of the project, one should ascertain why, despite the attainment of legal, political and social rights, there exists a significant inequality between the genders when it comes to achieving and exercising power and influence in the Federal ALP and the Victorian Branch. By researching those factors that create inequality, I hope to ascertain why women have been excluded from decision-making positions in the ALP and the Victorian Branch and document what changes have occurred and suggest future directional aims.


Current Web search engines are built to serve all users, independent of the special needs of any individual user. Personalization of Web search is to carry out retrieval for each user incorporating his/her interests. We propose a novel technique to learn user profiles from users' search histories. The user profiles are then used to improve retrieval effectiveness in Web search. A user profile and a general profile are learned from the user's search history and a category hierarchy, respectively. These two profiles are combined to map a user query into a set of categories which represent the user's search intention and serve as a context to disambiguate the words in the user's query. Web search is conducted based on both the user query and the set of categories. Several profile learning and category mapping algorithms and a fusion algorithm are provided and evaluated. Experimental results indicate that our technique to personalize Web search is both effective and efficient.


Two studies examined the effect of exposure to sexism on implicit gender bias, focusing specifically on stereotypes of men as competent and women as warm. Male and female participants were exposed to sexism or no-sexism. In both Experiment 1 (Implicit Association Task; N = 115) and Experiment 2 (Go/No-go Association Task; N = 167), women who had been exposed to sexist beliefs demonstrated less implicit gender stereotype bias relative to women who were not exposed to sexism. In contrast, exposure to sexism did not influence men's implicit gender stereotype bias. In Experiment 2, process modelling revealed that women's reduction in bias in response to sexism was related to increased accuracy-orientation and a tendency to make warmth versus competence judgments. The implications of these findings for current understandings of sexism and its effects on gender stereotypes are discussed.


By performing density functional theory-based calculations, we investigate how structural, electronic and mechanical properties of single layer ReS2 can be tuned upon hydrogenation of its surfaces. It is found that a stable, fully hydrogenated structure can be obtained by formation of strong S-H bonds. The optimized atomic structure of ReS2H2 is considerably different than that of the monolayer ReS2 which has a distorted-1T phase. By performing phonon dispersion calculations, we also predict that the Re2-dimerized 1T structure (called 1TRe2) of the ReS2H2 is dynamically stable. Unlike the bare ReS2 the 1TRe2–ReS2H2 structure which is formed by breaking the Re4 clusters into separated Re2 dimers, is an indirect-gap semiconductor. Furthermore, mechanical properties of the 1TRe2 phase in terms of elastic constants, in-plane stiffness (C) and Poisson ratio (ν) are investigated. It is found that full hydrogenation not only enhances the flexibility of the single layer ReS2 crystal but also increases anisotropy of the elastic constants.


Information extraction systems are traditionally implemented as a pipeline of special-purpose processing modules targeting the extraction of a particular kind of information. A major drawback of such an approach is that whenever a new extraction goal emerges or a module is improved, extraction has to be reapplied from scratch to the entire text corpus even though only a small part of the corpus might be affected. In this paper, we describe a novel approach for information extraction in which extraction needs are expressed in the form of database queries, which are evaluated and optimized by database systems. Using database queries for information extraction enables generic extraction and minimizes reprocessing of data by performing incremental extraction to identify which part of the data is affected by the change of components or goals. Furthermore, our approach provides automated query generation components so that casual users do not have to learn the query language in order to perform extraction. To demonstrate the feasibility of our incremental extraction approach, we performed experiments to highlight two important aspects of an information extraction system: efficiency and quality of extraction results. Our experiments show that in the event of deployment of a new module, our incremental extraction approach reduces the processing time by 89.64 percent as compared to a traditional pipeline approach. By applying our methods to a corpus of 17 million biomedical abstracts, our experiments show that the query performance is efficient for real-time applications. Our experiments also revealed that our approach achieves high quality extraction results.


SUMMARY Crustal scale seismic images provide information on the geometry of subsurface structure. In this paper we examine shear zones as they provide geometrical constraints on the evolution of the crust and as they provide pathways for the migration of mineral-rich fluids from the lower crust. However, they typically appear in seismic images of the deep crust as laterally continuous bands of discontinuous reflections with individual reflections often having high amplitudes. Geological mapping of exposed shear zones show them to have a complex 3-D structure yet crustal-scale seismic reflection surveys use single or at the most only a few profiles, and therefore only create 2-D images of these structures. The processing and imaging of the multifold common midpoint (CMP) data assumes that the seismic energy comes entirely from within the plane of the section. In this paper, we use full-waveform 3-D synthetic data to consider the effects that 3-D topography on a reflector has on reflection character on a 2-D profile. We base our synthetics on an observed shear zone and test models with both a single layer and anastomizing layers. We show that topography on the reflector out of the plane of the section may cause spurious events both above and below the expected target depth. We derive the basic understanding using a simple isotropic homogeneous model, however, we then demonstrate that this is a robust phenomenon and is endemic on all 2-D sections even if the overburden is not homogeneous. We demonstrate that we obtain similar results with a velocity gradient or, for a more extreme case, with a 2-km-deep basin filled with low-velocity sediment. For crustal scale seismic profiles, in particular, the effect is pervasive as neither stacking nor migration can discriminate against out-of-plane energy and the 2-D stack represents the 3-D seismic response of a broad swath centred on the profile. However, we conclude that using the modelled data it is possible to identify qualitatively where there is significant contamination from out-of-plane topography and show examples from a shear zone in the Archaean Yilgarn Block in Western Australia.


ABSTRACT Frugal innovation and related concepts are receiving increasing scholarly attention. While recent progress in the conceptualisation of frugal innovation as a phenomenon has been considerable, insights into the antecedents of frugal innovation remain relatively poor. We add to this literature by systematically conceptualising, theorising and empirically testing the relationship between resource constraints and the propensity of firms to produce frugal innovations, drawing on concepts of problemistic search and opportunity recognition. We distinguish two levels of resource constraints (firm-level and firm environment-level), and two types of frugal innovation (internally oriented and customer-oriented), while using managerial experience as a moderating internal factor. We find that firm-level resource constraints have a strong effect on the propensity of firms to engage in internally oriented frugal innovation, although only so for firms with experienced managers. This effect is lower when these firms operate in an environment that also faces high constraints. We find no effect of resource constraints on customer-oriented frugal innovations, but find a surprising negative moderating effect of managerial experience. We discuss the theoretical and policy implications of these findings for the frugal and wider innovation literature. This study is the first large-scale empirical investigation of frugal innovation that estimates its prevalence. We find that frugal innovation is quite common when using the widest definition of frugal innovation. The majority of frugal innovations are mundane internal efficiency upgrades through capital investment.


We compared the differences between spring and autumn in migration speed, fuelling rates and fuel loads of migrating Red Knots Calidris canutus. As a basis we used ringing data from Ottenby Bird Observatory, southeastern Sweden, collected 1948–2003, with morphometrical data from 1990–2003. Numbers ringed varied between 0 and 301 per year (average 56). Morphometrics, recoveries and recaptures of ringed birds indicated that most birds belonged to the Afro-Siberian subspecies C. c. canutus, possibly mixed with some Nearctic Red Knots C. c. islandica. Median trapping dates were 5 August (adults) and 31 August (juveniles). Mean body masses were low and almost equal for adults (111.8 g) and juveniles (111.4 g). The mean estimated fuel loads were 13–14% of lean body mass (LBM). In juveniles fuel loads increased with date. Among the few birds stopping over for longer than one day (2% of adults, 14% of juveniles), adult birds stayed on average 2.5 days and juveniles 3.4 days, with an overall average fuel deposition rate of 2.8% of LBM d–1. The autumn migration speed was estimated from ringing recoveries at 86 km d–1, which equals the speed of spring migration calculated from published information. The observed fuelling rate was as high as that of Red Knots at major spring stopover sites. We conclude that migration in autumn is as fast as in spring, although the generally small fuel loads indicate that migration is carried out in much smaller steps.


In the last quarter of the twentieth century, the global political economy has undergone a profound transformation. Democracy has swept the globe, and both rich and developing nations must compete in an increasingly integrated world economy. How are social welfare policies being affected by this wave of economic globalization? Leading researchers explore the complex question in this new comparative study. Shifting their focus from the more commonly studied, established welfare states of northwestern Europe, the authors of Globalization and the Future of the Welfare State examine policy development in the middle-in-come countries of southern and eastern Europe, Latin America, Russia, and East Asia. Previous investigations into the effects of globalization on welfare states have generally come to one of two conclusions. The first is that a global economy undermines existing welfare states and obstructs new developments in social policy, as generous provisions place a burden on a nation's resources and its ability to compete in the international marketplace. In contrast, the second builds on the finding that economic openness is positively correlated with greater social spending, which suggests that globalization and welfare states can be mutually reinforcing. Here the authors find that globalization and the success of the welfare state are by no means as incompatible as the first view implies. The developing countries analyzed in Globalization and the Future of the Welfare State demonstrate that although there is great variability across countries and regions, domestic political processes and institutions play key roles in managing the disruptions wrought by globalization.


Collective behavior has been observed in high-energy heavy-ion collisions for several decades. Collectivity is driven by the high particle multiplicities that are produced in these collisions. At the Large Hadron Collider (LHC), features of collectivity have also been seen in high-multiplicity proton-proton collisions that can attain particle multiplicities comparable to peripheral Pb-Pb collisions. One of the possible signatures of collective behavior is the decrease of femtoscopic radii extracted from pion and kaon pairs emitted from high-multiplicity collisions with increasing pair transverse momentum. This decrease can be described in terms of an approximate transverse mass scaling. In the present work, femtoscopic analyses are carried out by the ALICE collaboration on charged pion and kaon pairs produced in pp collisions at $\sqrt{s}=13$ TeV from the LHC to study possible collectivity in pp collisions. The event-shape analysis method based on transverse sphericity is used to select for spherical versus jet-like events, and the effects of this selection on the femtoscopic radii for both charged pion and kaon pairs are studied. This is the first time this selection method has been applied to charged kaon pairs. An approximate transverse-mass scaling of the radii is found in all multiplicity ranges studied when the difference in the Lorentz boost for pions and kaons is taken into account. This observation does not support the hypothesis of collective expansion of hot and dense matter that should only occur in high-multiplicity events. A possible alternate explanation of the present results is based on a scenario of common emission conditions for pions and kaons in pp collisions for the multiplicity ranges studied.


Background Understanding the cancer genome is seen as a key step in improving outcomes for cancer patients. Genomic assays are emerging as a possible avenue to personalised medicine in breast cancer. However, evolution of the cancer genome during the natural history of breast cancer is largely unknown, as is the profile of disease at death. We sought to study in detail these aspects of advanced breast cancers that have resulted in lethal disease. Methods and Findings Three patients with oestrogen-receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer and one patient with triple negative breast cancer underwent rapid autopsy as part of an institutional prospective community-based rapid autopsy program (CASCADE). Cases represented a range of management problems in breast cancer, including late relapse after early stage disease, de novo metastatic disease, discordant disease response, and disease refractory to treatment. Between 5 and 12 metastatic sites were collected at autopsy together with available primary tumours and longitudinal metastatic biopsies taken during life. Samples underwent paired tumour-normal whole exome sequencing and single nucleotide polymorphism (SNP) arrays. Subclonal architectures were inferred by jointly analysing all samples from each patient. Mutations were validated using high depth amplicon sequencing. Between cases, there were significant differences in mutational burden, driver mutations, mutational processes, and copy number variation. Within each case, we found dramatic heterogeneity in subclonal structure from primary to metastatic disease and between metastatic sites, such that no single lesion captured the breadth of disease. Metastatic cross-seeding was found in each case, and treatment drove subclonal diversification. Subclones displayed parallel evolution of treatment resistance in some cases and apparent augmentation of key oncogenic drivers as an alternative resistance mechanism. We also observed the role of mutational processes in subclonal evolution. Limitations of this study include the potential for bias introduced by joint analysis of formalin-fixed archival specimens with fresh specimens and the difficulties in resolving subclones with whole exome sequencing. Other alterations that could define subclones such as structural variants or epigenetic modifications were not assessed. Conclusions This study highlights various mechanisms that shape the genome of metastatic breast cancer and the value of studying advanced disease in detail. Treatment drives significant genomic heterogeneity in breast cancers which has implications for disease monitoring and treatment selection in the personalised medicine paradigm.


This Article calls into question the fundamental premises of models of judicial decisionmaking utilized by legal and political science scholars. In the place of the predominant theories, I offer a new approach to understanding judicial behavior which recognizes judicial heterogeneity, multidimensional behavior, and interconnectedness among judges at different levels within the judiciary. The study utilizes a unique dataset of over 30,000 judicial votes from eleven courts of appeals in 2008, yielding statistically independent measures for judicial activism, ideology, independence, and partisanship. Based upon those four metrics, statistical cluster analysis is used to identify nine statistically distinct judging styles: Trailblazing, Consensus Building, Stalwart, Regulating, Steadfast, Collegial, Incrementalist, Minimalist, and Error Correcting. These judicial style types offer a fuller account of judicial behavior than any of the prior models utilized by scholars.


In this work we present the Stark widths (W) of 22 neutral (Cu I) and 100 singly ionized (Cu II) copper spectral lines that have been measured at 18 400 K and 19 300 K electron temperatures and 6.3 × 10 22 m−3 and 2.1 × 10 23 m−3 electron densities, respectively. The experiment is conducted in the laser-induced plasma—the Nd:YAG laser, operating at 532 nm, was used to produce plasma from the copper sample in the residual air atmosphere at a pressure of 8 Pa. The electron temperature and density were estimated by the Boltzmann-plot method and from the Saha equation. The investigated Cu I lines belong to the 4s–4p′, 4s 2–4p″ and 4p′–4d′ transitions while Cu II spectral lines belong to the 4s–4p, 4p–5s, 4p–4d, 4p–4s 2, 4d–4f and 4d–v transitions. Comparison with existing experimental data was possible only in the case of 17 Cu II lines due to a lack of experimental and theoretical values. The rest of the data, Stark widths of 22 Cu I and 83 Cu II lines are published for the first time.


This paper investigates the impact of outsourcing on sectoral reallocation in the U.S. over the period 1947-2007, and on the rise in services in particular. Roughly 40% of the growth of the service sector comes from professional and business services. This is an unusual industry as more than 90% of its output is an intermediate input to other firms, and it is where most of the service outsourcing activity is concentrated. These facts are essential to understanding the structure of the economy: professional and business services have experienced an almost fourfold increase in their forward linkage, the largest change in input-output linkages over the past 60 years. Using a simple gross output accounting framework, I calculate the contribution of the change in the composition of intermediates and their sourcing mode to the reallocation of employment across sectors. I find that the evolution of the input-output structure accounts for up to 33% of the increase in service employment, and professional and business services outsourcing alone contributes almost half of that amount.


The increasing amount of publicly available literature and experimental data in biomedicine makes it hard for biomedical researchers to stay up-to-date. Genescene is a toolkit that will help alleviate this problem by providing an overview of published literature content. We combined a linguistic parser with Concept Space, a co-occurrence based semantic net. Both techniques extract complementary biomedical relations between noun phrases from MEDLINE abstracts. The parser extracts precise and semantically rich relations from individual abstracts. Concept Space extracts relations that hold true for the collection of abstracts. The Gene Ontology, the Human Genome Nomenclature, and the Unified Medical Language System, are also integrated in Genescene. Currently, they are used to facilitate the integration of the two relation types, and to select the more interesting and high-quality relations for presentation. A user study focusing on p53 literature is discussed. All MEDLINE abstracts discussing p53 were processed in Genescene. Two researchers evaluated the terms and relations from several abstracts of interest to them. The results show that the terms were precise (precision 93%) and relevant, as were the parser relations (precision 95%). The Concept Space relations were more precise when selected with ontological knowledge (precision 78%) than without (60%).


Perturbing a signaling system with a serial of single gene deletions and then observing corresponding expression changes in model organisms, such as yeast, is an important and widely used experimental technique for studying signaling pathways. People have developed different computational methods to analyze the perturbation data from gene deletion experiments for exploring the signaling pathways. The most popular methods/techniques include K-means clustering and hierarchical clustering techniques, or combining the expression data with knowledge, such as protein-protein interactions (PPIs) or gene ontology (GO), to search for new pathways. However, these methods neither consider nor fully utilize the intrinsic relation between the perturbation of a pathway and expression changes of genes regulated by the pathway, which served as the main motivation for developing a new computational method in this study. In our new model, we first find gene transcriptomic modules such that genes in each module are highly likely to be regulated by a common signal. We then use the expression status of those modules as readouts of pathway perturbations to search for up-stream pathways. Systematic evaluation, such as through gene ontology enrichment analysis, has provided evidence that genes in each transcriptomic module are highly likely to be regulated by a common signal. The PPI density analysis and literature search revealed that our new perturbation modules are functionally coherent. For example, the literature search revealed that 9 genes in one of our perturbation module are related to cell cycle and all 10 genes in another perturbation module are related by DNA damage, with much evidence from the literature coming from in vitro or/and in vivo verifications. Hence, utilizing the intrinsic relation between the perturbation of a pathway and the expression changes of genes regulated by the pathway is a useful method of searching for signaling pathways using genetic perturbation data. This model would also be suitable for analyzing drug experiment data, such as the CMap data, for finding drugs that perturb the same pathways.


Small Animal Anesthesia Techniques provides a quick reference to protocols for anesthetizing canine, feline, and exotic animal patients in veterinary practice. This portable companion provides complete information on anesthetic procedures, from the basics of pharmacology, physiology, and equipment to handling challenging procedures and the compromised patient. A companion website features videos, images, and worksheets for calculations. The book offers an overview of the anesthetic process, with tips on how to anticipate and avoid complications, with example protocols for specific patients. Veterinarians and veterinary technicians will find this how-to guide to providing anesthesia to be an ideal resource for fast access to drug dosages, anesthesia protocols, and special considerations for specific procedures.


Flexible optoelectronic devices have attracted considerable attention due to their low weight, portability, and ease of integration with other devices. However, major issues still exist: they are subject to repeated stresses, which often leads to damage; and the current fabrication methods such as photolithography and nano-imprint lithography can be very time-consuming or costly. This work aims to develop a novel cost-effective and time-efficient laser metasurface fabrication (LMF) technique for production of flexible optoelectronic devices. The experimental results have shown that the laser patterned flexible surfaces exhibit high visible transmittance, low sheet resistance, and extraordinary mechanical durability under repeated bending cycles. The laser patterned flexible surfaces have also demonstrated the potential to be utilized as heaters, which renders them new de-icing or de-fogging applications. This innovative laser patterning method will provide a new avenue for fabrication of multifunctional optoelectronic devices.


Namibia and South Africa as part of Southern Africa are focussing on new technologies which on the one hand have the capacity to address energy shortages, particularly to increase power generation capacity; and on the other hand fulfil socio-economic development goals with minimal negative environmental impact. Bio-oil as a product from fast pyrolysis lends itself towards bioenergy production; to serve as a liquid fuel both for heat production and/or to fuel stationary engines or power generating equipment. Fast pyrolysis is a relatively new technology globally; and not yet introduced to Southern Africa. This research therefore describes bioenergy production via fast pyrolysis systems. The potential of the bioenergy so produced is investigated in terms of its potential to fill energy gaps, particularly power, as well as to fulfil socio-economic and environmental conservation targets in Namibia and South Africa. Namibia and South Africa possess vast wood-based biomass resources which can be converted to bioenergy via fast pyrolysis. This research models the wood-based biomass resources available for bioenergy production in Namibia and South Africa respectively; describes their physical and chemical properties and provides information on where they are located within, and how they can be harvested in a sustainable manner in Namibia and South Africa. The analysis to introduce fast pyrolysis into the Namibia and South Africa is based on an in-depth review of past experiences with pyrolysis technologies and the types of products successfully sold from various pyrolysis operations. The results of biomass modelling and description are used to model a bioenergy production system via fast pyrolysis. In Namibia fast pyrolysis operations are focusing on power generation in the Otjiwarongo and Okakarara farmland area, with a capacity of up to 20MW over a 20-year period. The power so generated is based on wood from bush encroachment only. In South Africa, the wood-based resource, i.e. alien plant species and bush encroachment, could provide communities in three provinces with at least 1MW but not more than 5MW power respectively over a period of at least 20 years. However, the introduction of new technologies and their products, such as fast pyrolysis and bio-oil for bioenergy production to Namibian and South African markets would be cumbersome. Technical and non-technical as well regulatory barriers have been identified; these need to be overcome before fast pyrolysis is accepted in the market.


In Mobile ad hoc networks (MANET), Providing QoS guarantee is difficult task due to unreliable Wireless nature of Link, Mobility, Lacking of Centralized Coordination and Channel contention. For Real-time applications (such as video, audio) QoS is More important on transmissions. Many efforts are put on ad hoc networks at both the MAC and routing layers Meanwhile, QoS aware issues are considered in both MAC and routing layers for ad hoc networks. However QoS can ensure by Admission control protocols and reservation mechanisms. This paper aims to investigate factors affecting QoS, admission control protocols, QoS routing protocols, reservation mechanisms, and MAC Layer QoS Supports. This is also aims to provide deep view of QoS in MANET Of current and Future trends.


As the prevalence of tobacco use has decreased, it has become clear that individuals with mental illness comprise a substantial portion of the remaining smokers. Seventy to eighty percent of patients with schizophrenia smoke and their smoking is established before their first psychotic episodes or the initiation of treatment. Many patients with schizophrenia, and approximately 50% of their first degree relatives have abnormalities in auditory sensory gating and/or smooth pursuit eye movements. These abnormalities are corrected by nicotine, and they appear to be transmitted as autosomal dominant traits. Evidence is accumulating that these abnormalities reflect genetic variations in nicotine receptor number and function, that may increase susceptibility for schizophrenia. Recent studies suggest that bupropion, added to treatment with an atypical antipsychotic, can enhance the likelihood of smoking cessation or reduction in patients with schizophrenia. The prevalence of smoking is also substantially increased among patients with bipolar disorder, perhaps especially so among those with psychotic features. Nicotine delivered by gum or transdermal patch can provide short term relief for exacerbations of Tourette's Syndrome, but its use is limited by frequent toxicity, primarily nausea.


Optogenetics employs light exposure to manipulate physiology in genetically modified organisms. There are abundant tools for optogenetic excitation of neuronal activity, but the limitations of current activity photo-inhibitors present an obstacle to demonstrating the necessity of specific neuronal circuits. Here we show that anion channelrhodopsins can be used to specifically and rapidly inhibit a range of systems involved in Drosophila locomotion, wing expansion, memory retrieval and gustation, demonstrating their broad utility to the circuit analysis of behavior.


We present novel algorithms for modeling interactive diffuse reflections and higher-order diffraction in large-scale virtual environments. Our formulation is based on ray-based sound propagation and is directly applicable to complex geometric datasets. We use an incremental approach that combines radiosity and path tracing techniques to iteratively compute diffuse reflections. We also present algorithms for wavelength-dependent simplification and visibility graph computation to accelerate higher-order diffraction at runtime. The overall system can generate plausible sound effects at interactive rates in large, dynamic scenes that have multiple sound sources. We highlight the performance in complex indoor and outdoor environments and observe an order of magnitude performance improvement over previous methods.


Team work can have a positive impact on student learning and commitment, but it is challenging to determine a method of assessment that does not require lecturers to involve themselves intimately with each team. Team members are often the best source of meaningful data, and as a result, lecturers are including self and peer assessment. One method of peer assessment is to have team members quantify their own contribution and that of team members. Concerns have been raised in the literature about distribution patterns with this method of peer assessment. An online peer assessment system has been capturing data from a capstone project course for three years with over 24 teams and 100 students each year. This paper analyses the following questions: do students take the easy option of equal distribution to avoid conflict, are students honest about their own contribution, are females treated fairly and are international students unfairly discriminated against.


Safranbolu is known for the abundance of its water resources. The city is a unique and historic settlement that hosts very beautiful examples of traditional Turkish architecture. The city attracts both national and international tourists. In this paper, firstly the Ottoman period water supply structures of Safranbolu are described. Incekaya Aqueduct and water transmission system, also known as the Pasha Water Supply System or Spring System are discussed. The Incekaya Aqueduct delivers drinking water from the spring at Danakoy Village to Safranbolu enabling the transfer over the Tokatli Canyon via gravity. This aqueduct, a very historic and aesthetically pleasing water structure, was commissioned as a city asset by Ottoman Grand Vizier Izzet Mehmet Pasha in the period of 1794–98. The paper secondly discusses the pool rooms that serve as an example of the spatial usage of water features in traditional residential architecture of the Ottoman period in Safranbolu. The pool rooms were constructed either within or separate from the traditional Safranbolu mansions. Asmazlar Mansion in Safranbolu and Deligozler House in the Baglar District have been evaluated as examples of pool rooms within the house, and two garden pools in the Baglar and central districts are assessed as examples of outside pools, known as pavilion mansions with a garden pool.


Assessment is an essential aspect of teaching and learning. Not only is assessment necessary to determine whether students have learned what teachers think they have taught, but it also informs the design of instruction and is used to adjust the specific teaching and learning strategies that are used over time. Numerous technological tools are available that enable teachers to be more efficient and effective with this process. This chapter is primarily concerned with the assessment of musical achievement in creative, psychomotor, and cognitive domains. It outlines essential assessment principles, discusses the technology-assisted development of assessments, explores technologies helpful to the process of assessing specific music learning outcomes, and describes new assessment approaches enabled by technology. The management of assessment data and processes via technology is also examined.


This paper addresses the integration of domestic financial markets in Western Pacific economies – an unexamined issue in the literature of international financial integration – by exploring the relationship between money market interest rates and deposit and loan interest rates. Rules for setting interest rates on deposits and loans are derived, and these are shown to be consistent with commercial banking practice and to capture recent key developments in the banking sectors of the region. An error-correction model is used to show that the integration of domestic institutional financial markets has increased substantially over the past decade, due to pervasive liberalisation and, more recently, growing competitiveness. The adjustment of domestic institutional rates to changes in money market rates has increased, often significantly, and by the first half of the 1990s the speed and pattern of adjustment of institutional rates in most of the developing/newly developed economies of East Asia had become similar to that in economies with developed financial systems. There is also a difference between the adjustment of deposit and loan rates, with the former adjusting more rapidly. This may be explained by differences in the maturity, substitutability and transactions costs associated with loans and deposits. The riskiness of private borrowers and the poor health of the banking system were shown to have a significant, deleterious effect on the level of loan rates in the region. Country differences are analysed and implications for monetary policy, competition policy and supervision policy are noted.


Autism Spectrum Disorder (ASD) is often accompanied by atypical attention to faces. Some previous studies have suggested that children with ASD demonstrate strengths when processing visual information from cartoons, whereas others have argued that photographic stimuli confer benefits. No previous studies have compared photograph and cartoon images of faces (i.e., Boardmaker [BM] images) in the context of a Social StoryTM (Gray, 2010): a common intervention to support behavior and social cognition in children with ASD. In this study, we examined visual attention to static face stimuli in the context of Social StoriesTM. Participants were 19 typically developing (TD) children and 18 agematched children with ASD. We addressed two questions: 1) Is there a difference between TD children and children with ASD in how they attend to cartoon and photographic stimuli in the context of a Social StoryTM? and 2) Do group differences in visual attention to BM and/or photographic stimuli correlate with age and indices of autism severity, executive function, intellectual functioning, and weak central coherence? With regard to question 1 and with one exception, we found no differences between groups when viewing images of faces. The exception involved our cartoon and photograph images that differed in content from the other face images in that they represented a person's full body as well as a range of objects (i.e., it was a more complex scene). For these images an interaction was observed such that the TD and ASD groups were no different in their looking patterns in the BoardMaker condition but they were different in the photograph condition. More specifically, we found that a shift toward more mouth-looking in the photograph condition among children with ASD was negatively associated with attention shifting and verbal IQ and that a shift toward more 'other'-looking (i.e., looking that occurred outside the eye and mouth region of the face) was negatively associated with attention shifting, age, and central coherence. These findings suggest that children with ASD demonstrate typical visual attention patterns to both cartoon and photographic stimuli representing faces but that children with ASD employ an atypical scanning strategy when presented with photographic stimuli representing more complex social scenes. The theoretical and clinical implications of the findings are discussed.


A union of matter bounce and Ekpyrotic scenarios is often studied in an attempt to combine the most promising features of these two models. Since non-perturbative quantum geometric effects in loop quantum cosmology (LQC) result in natural bouncing scenarios without any violation of energy conditions or fine tuning, an investigation of matter-Ekpyrotic bounce scenario is interesting to explore in this quantum gravitational setting. In this work, we explore this unified phenomenological model for a spatially flat Friedmann-Lema\^itre-Robertson-Walker (FLRW) universe in LQC filled with dust and a scalar field in an Ekpyrotic scenario like negative potential. Background dynamics and the power spectrum of the comoving curvature perturbations are numerically analyzed with various initial conditions and a suitable choice of the initial states. By varying the initial conditions we consider different cases of dust and Ekpyrotic field domination in the contracting phase. We use the dressed metric approach to numerically compute the primordial power spectrum of the comoving curvature perturbations which turns out to be almost scale invariant for the modes which exit the horizon in the matter-dominated phase. But, in contrast with a constant magnitude power spectrum obtained under approximation of a constant Ekpyrotic equation of state using deformed algebra approach in an earlier work, we find that the magnitude of power spectrum changes during evolution. Our analysis shows that the bouncing regime only leaves imprints on the modes outside the scale-invariant regime. However, an analysis of the spectral index shows inconsistency with the observational data, thus making further improvements in such a model necessary.


Between 1873 and 1945 Japan and Mongolia had a complex and important relationship that has been largely overlooked in post-war studies of Japan's imperial era. In fact, Japanese-Mongolian relations in the modern period provide a rich field of enquiry into the nature of Japanese imperialism as well as further evidence of the complexity of Japan's relationships with other Asian countries in the decades before 1945. This thesis examines the relationship from the Japanese perspective, drawing on a diverse range of contemporary materials, both official and unofficial, including military documents, government reports, travel guides and academic works, many of which have been neglected in earlier studies. In previous analyses, the strategic dimension has been seen as overwhelming and Mongolia has often been regarded as merely a minor addendum to Japan's relationship with Manchuria. In fact, however, Japan's connection with Mongolia itself was a crucial part of its interaction with the Chinese continent from the 1870s to 1945. Though undeniably coveted for strategic reasons, Mongolia also offered unparalleled opportunities for the elaboration of all the major aspects of the discourses that made up Japan's evolving claim to solidarity with and leadership of Asia. It also functioned as a showcase for Japan's supposedly benevolent intentions towards Asia. In some ways, moreover, the relationship with Mongolia was presented as distinctive, particularly because of the common faith in Buddhism and a supposedly shared ancestry in ethnic terms. In turn, the military, political, ideological and cultural opportunities apparently provided by Mongolia account for the wide range of groups and individuals in Japan that developed Mongolian connections and for the often close relations between these groups and individuals on the one hand, and the most powerful institutions of the Japanese state on the other.


The paper presents a simplified one-dimensional calculation of the efficiency hill-chart for Francis turbines, based on the velocity triangles at the inlet and outlet of the runner's blade. Calculation is done for one streamline, namely the shroud streamline in the meridional section, where an efficiency model is established and iteratively approximated in order to satisfy the Euler equation for turbomachines at a wide operating range around the best efficiency point (BEP). Using the presented method, hill charts are calculated for one splitter-bladed Francis turbine runner and one Reversible Pump-Turbine (RPT) runner operated in the turbine mode. Both turbines have similar and relatively low specific speeds of nsQ = 23.3 and nsQ = 27, equal inlet and outlet diameters and are designed to fit in the same turbine rig for laboratory measurements (i.e. spiral casing and draft tube are the same). Calculated hill charts are compared against performance data obtained experimentally from model tests according to IEC standards for both turbines. Good agreement between theoretical and experimental results is observed when comparing the shapes of the efficiency contours in the hill-charts. The simplified analysis identifies the design parameters that defines the general shape and inclination of the turbine's hill charts and, with some additional improvements in the loss models used, it can be used for quick assessment of the performance at off-design conditions during the design process of hydraulic turbines.


Background We have previously reported that human recombinant granzyme B (grB) mediates apoptosis in membrane heat shock protein 70 (Hsp70)-positive tumor cells in a perforin-independent manner. Methodology/Principal Findings Optical imaging of uptake kinetics revealed co-localization of grB with recycling endosomes (Rab9/11) as early as 5 min after internalization, with late endosomes (Rab7) after 30 min, and the lysosomal compartment (LAMP1/2) after 60 to 120 min. Active caspase-3-mediated apoptosis was induced in mouse CT26 monolayer cells and 3D tumor spheroids, but not in normal mouse endothelial cells. Granzyme B selectively reduced the proportion of membrane Hsp70-positive cells in CT26 tumor spheroids. Consecutive i.v. injections of recombinant human grB into mice bearing membrane Hsp70-positive CT26 tumors resulted in significant tumor suppression, and a detailed inspection of normal mouse organs revealed that the administration of anti-tumoral concentrations of grB elicited no clinicopathological changes. Conclusions/Significance These findings support the future clinical evaluation of human grB as a potential adjuvant therapeutic agent, especially for treating immunosuppressed patients that bear membrane Hsp70-positive tumors.


From his obsession with the founding principles of the United States to his cold-blooded killings in the battle over slavery's expansion, John Brown forced his countrymen to reckon with America's violent history, its checkered progress toward racial equality, and its resistance to substantive change. Tracing Brown's legacy through writers and artists like Thomas Hovenden, W. E. B. Du Bois, Robert Penn Warren, Jacob Lawrence, Kara Walker, and others, Blake Gilpin transforms Brown from an object of endless manipulation into a dynamic medium for contemporary beliefs about the process and purpose of the American republic.Gilpin argues that the endless distortions of John Brown, misrepresentations of a man and a cause simultaneously noble and terrible, have only obscured our understanding of the past and loosened our grasp of the historical episodes that define America's struggles for racial equality. By showing Brown's central role in the relationship between the American past and the American present, Gilpin clarifies Brown's complex legacy and highlights his importance in the nation's ongoing struggle with the role of violence, the meaning of equality, and the intertwining paths these share with the process of change.


Newborns characterized as large and small for gestational age are at risk for increased mortality and morbidity during the first year of life as well as for obesity and dysglycemia as children and adults. The intrauterine environment and fetal genes contribute to the fetal size at birth. To define the genetic architecture underlying the newborn size, we performed a genome-wide association study (GWAS) in 4281 newborns in four ethnic groups from the Hyperglycemia and Adverse Pregnancy Outcome Study. We tested for association with newborn anthropometric traits (birth length, head circumference, birth weight, percent fat mass and sum of skinfolds) and newborn metabolic traits (cord glucose and C-peptide) under three models. Model 1 adjusted for field center, ancestry, neonatal gender, gestational age at delivery, parity, maternal age at oral glucose tolerance test (OGTT); Model 2 adjusted for Model 1 covariates, maternal body mass index (BMI) at OGTT, maternal height at OGTT, maternal mean arterial pressure at OGTT, maternal smoking and drinking; Model 3 adjusted for Model 2 covariates, maternal glucose and C-peptide at OGTT. Strong evidence for association was observed with measures of newborn adiposity (sum of skinfolds model 3 Z-score 7.356, P = 1.90×10⁻¹³, and to a lesser degree fat mass and birth weight) and a region on Chr3q25.31 mapping between CCNL and LEKR1. These findings were replicated in an independent cohort of 2296 newborns. This region has previously been shown to be associated with birth weight in Europeans. The current study suggests that association of this locus with birth weight is secondary to an effect on fat as opposed to lean body mass.


The Frequency Assignment Problem (FAP) is an important optimization problem that arises in operational cellular wireless networks. Solution techniques based on meta-heuristic algorithms have been shown to be successful for some test problems but they have not been usually demonstrated on large scale problems that occur in practice. This thesis applies a problem decomposition approach in order to solve FAP in stances with standard meta-heuristics. Three different formulations of the problem are considered in order of difficulty: Minimum Span (MS-FAP), Fixed Spectrum (MS-FAP), and Minimum Interference FAP (MI-FAP). We propose a decomposed assignment technique which aims to divide the initial problem into a number of subproblems and then solves them either independently or in sequence respecting the constraints between them. Finally, partial subproblem solutions are recomposed into a solution of the original problem. Standard implementations of meta-heuristics may require considerable run times to produce good quality results whenever a problem is very large or complex. Our results, obtained by applying the decomposed approach to a Simulated Annealing and a Genetic Algorithm with two different assignment representations (direct and order-based), show that the decomposed assignment approach proposed can improve their outcomes, both in terms of solution quality and runtime. A number of partitioning methods are presented and compared for each FAP, such as clique detection partitioning based on sequential orderings and novel applications of existing graph partitioning and clustering methods adapted for this problem.


Detailed geomorphologic characteristics need to be compiled for performing hydrologic modeling of a basin. Basin form and hydrologic characteristics are to be related so the basin form must also be represented by quantitative descriptors. The typical morphologic characteristics used in hydrological analyses are basin area, perimeter, mainstream length, total stream length, contour length, basin shape (form factor, circularity ratio, compactness ratio, basin elongation), slope, drainage density, relief (maximum relief, relief ratio, relative relief), effective basin width, and median elevation. The objective of this study is to propose an algorithm to automatically calculate basin characteristics using vector GIS. The results produced by the algorithm were compared to the manual method and the two methods were found statistically similar.


This paper presents an historical survey of the live project in architectural education, proposing that the live project can be conceptualised within three distinct periods: a modern period, a transitional period, and a (contemporary) postmodern period. This paper proposes that an evolution from a modern conception of the live project to a postmodern conception provides insight to attitudinal shift in architectural education. In order to explore what pedagogical frameworks might we help to theorising these contemporary forms, the paper contextualises architecture live project practice against pedagogical mechanisms of client-centred learning in three other disciplines.


The study of the motion of perfect fluids is of paramount importance for the understanding of the chief phenomena occurring in the air surrounding an aircraft, and for the numerical determination of their effects. The author recently successfully employed some simple methods for the investigation of the flow of a perfect fluid that have never been mentioned in connection with aeronautical problems. These methods appeal particularly to the engineer who is untrained in performing laborious mathematical computations, as they do away with these and allow one to obtain many interesting results by the mere application of some general and well-known principles of mechanics. Discussed here are the kinetic energy of moving fluids, the momentum of a body in a perfect fluid, two dimensional flow, three dimensional flow, and the distribution of the transverse forces of very elongated surfaces of revolution.


Rural youth are leaving their home communities in search of economic opportunity. Students' residential, occupational, and educational aspirations are effective predictors of life choices, such as future residence. This study's purpose was to determine the aspirations of rural students in Arkansas overall, and by locale. This study used descriptive survey methodology and a stratified random sample of 15 rural schools to determine the respondents' (n = 133) aspirations, expectations for the future, and perception(s) of their home community. Overall, a majority of respondents indicated they want to leave their home communities and obtain at least a bachelor's degree. Nearly half aspired to work in health sciences or education. Moderate associations were found between the respondents' residential and educational aspirations. Weak associations were also found for respondents' expectations and locale code. Students indicated that occupational and educational barriers were similar. Lack of money for school, poor job markets, and family responsibilities were the most frequent barriers for a majority of respondents overall. Good paying jobs, many chances to get ahead, and indoor entertainment were the community characteristics for which respondents indicated high importance, but low satisfaction. As for students' perceptions of their home communities, responses provided were fairly low to neutral. Negligible to small effect sizes were found when describing differences by rural code for perceptions of community, perceived importance of community characteristics, and satisfaction with community characteristics. The residential aspirations of these respondents resemble individuals involved in the brain drain. Responses provided from respondents concerning their aspirations supports previous research regarding the aspirations of rural students. These students' responses also reflect concepts associated with achievement motivation, social comparison, and human capital theory. Based on these findings, this study recommends conducting future research regarding more in-depth information concerning rural Arkansas youth's aspirations. Additionally, for school districts whose students are similar to those in this study, counselors and administrators should provide opportunities college prep, such as, applying for financial aid, and hosting ACT and college entrance requirement workshops. Finally, based on respondents' low perceptions of their communities, similar communities should consider providing opportunities such as job fairs, job shadowing, and mentorship programs.


This work discusses the potential of process optimization for simultaneous fixation of reactive printing and crease resistant finishing with the help of desirability function. A single step process for reactive printing and crease resistant finishing of cotton fabric is described. The idea is a model based approach due to the complexity of the chemical and physical operational sequence of the combo process. The optimum conditions, including concentration of dye and crease resistant, fixation method and temperature were also investigated. Evaluations of the process were made with respect to K/S, dry and wet crease recovery, tensile and tear strength, fastness to washing, light & rubbing, resistance to abrasion and pilling. An E-Control fixation at a temperature of 135 ˚C was proved to be efficient for imparting single-step reactive print fixation and crease resistant finishing to cotton fabric.


Wikis are a very versatile and easy-to-use tool that is finding increasing applications in teaching and learning. This paper will illustrate how teaching academics can join the wiki revolution. First. it will introduce the common wikis and then focus on Wikipedia, The Free Encyclopedia, which has become one of the most popular Internet sites and offers unique opportunities for teachers and learners. It will describe how wikis and Wikipedia are used as a teaching tool and how to develop them further.


In the broad research field on children's paintings the analysis of color is often neglected, so that findings on how children are using color are sparse. This study tries to fill this gap partially by empirically examining the use of color through a number of receptive, productive and reflexive tasks given to children aged 10 to 12. It seeks to develop a deeper understanding of visual competencies and observable color phenomena in children's paintings by using a multi method approach. Results of a perception test examining children's ability to differentiate color show, that almost all children can distinguish finest color nuances. Although accurate perception of color shades is presumably a fundamental prerequisite for reproducing hues, no direct correlation between color discrimination capability and results of color mixing exercises could be demonstrated. Investigating the use of color in more complex contexts reveals consistent tendencies across all tasks. Partial matches are found in the pursuit of contrast-rich, color-intensive effects and the avoidance of dull and bleak colors. In contrast, large inter- and intraindividual as well as inter- and intramedial variances of color scale, color application and reflexive abilities dominate the coloruse of the agegroup. The sum of the variations shows a striving for varied ways of dealing with the medium and the importance of influencing factors. The retention of universal, pure-developmental colorstagemodels is therefore not justified. The results prove that children have a repertoire of painting principles, which can be divided into three representational tendencies: perception-oriented-differentiated, formal-simplistic and individualistic-differentiated. These tendencies rarely appear in pure but rather in heterogeneous forms and must not be understood as separation-sharp types. Transitions prove to be fluid, the coloruse influenced by external influences. When taking the task into account, the comparison of observable phenomena reveals differences which lead to the construction of an elaborate and a basic competency-level. A number of criteria such as the scope of the repertoire, the quality and flexibility of the problem solution as well as the degree of reflection and the complexity of the work process define the two levels. A broad repertoire of representational tendencies combined with a high degree of reflection proves to be an essential component of high visual competence. Morover is the graduation of visual competence decisively characterized by a dynamic and flexible use of the repertoire. Accordingly, theories of multiple repertoires formulate an adequate response to varying situations as the endpoint of the development. The study shows that an isolated analysis of pictorial products falls short. In addition to productive competencies, receptive and reflexive competencies are also manifested in the products. The comparison of the pictorial results with the utterances of the children demonstrates the central role of reflexive, metacognitive aspects in dealing with color. In particular, the interpretation of the task and the resulting creative intentions are extremely important for the pictorial result and therefore also decisive for the graduation of the observed competencies. The inclusion of reflexive competencies in the investigation of visual competence thus appears to be a central factor for future research.


Conceptual Liquefied Natural Gas (LNG) Terminal Design for Kuwait. (May 2006) Fares Aljeeran, B.S., Kuwait University Chair of Advisory Committee: Dr. John M. Niedzwecki This research study investigated a new conceptual design for a modular structural configuration incorporating storage for Liquefied Natural Gas (LNG) within the base of the platform structure. The structure, referred to as a modified gravity base concrete structure (MGBCS), was envisioned specifically to be constructed at a suitable site off the coast of Kuwait. Coastal offshore bathometric information, environmental data and existing data on onshore facilities were examined in the site selection portion of the study. A finite element model of the MGBCS was developed using an industry standard finite element code that allows preliminary sizes of structural models to meet appropriate design codes. A variety of parametric and design load scenarios were investigated. This research tackles some preliminary issues that are adequate for an initial evaluation of the proposed design concept. The proposed design concept needs a lot more scrutiny in order to be sufficiently developed as a concept where it can be confirmed as a truly viable concept and investment. It was confirmed that quartering sea conditions, waves approaching at a 45 degree angle, are the most critical scenarios for the terminal based on maximum values and ranges of shears and moments. In addition, there are several interesting issues in this concept that should be further looked at for this design to be further developed. The limitations of our study must be mitigated in future designs if the proposed design concept is to be carried to the implementation stage.


The paper look inside the great changes occurred in the geography of Emilia Romagna region, during the Twentieth Century. It is a synthetic profile of different aspects, because most of the changes produced modifications on the landscape, and then on the geographies of the area. Varied sources are used, like documents, data, cartographic and iconographic materials, at the regional scale. The first two chapters deals with the land and infrastructure, whose networks have helped to strengthen the human geography of the region, based on the axis of the Via Emilia. The third chapter presents some indicators on population, its geographical distribution, its social and economic characteristics, showing the momentous changes that have occurred in the twentieth century. The fourth and fifth chapter attempt to get the level investigation into rural areas and urban contexts, using some indicators and iconographic materials. The sixth part deals with the contemporary environmental challenges, ranging from emergency of high land consumption, implemented through its overbuilding and the reduction of agricultural use areas, up to attempts to nature conservation through parks, reserves, and new-naturalized areas.


Problems of cooperation--in which agents seek ways to jointly improve their welfare--are ubiquitous and important. They can be found at scales ranging from our daily routines--such as driving on highways, scheduling meetings, and working collaboratively--to our global challenges--such as peace, commerce, and pandemic preparedness. Arguably, the success of the human species is rooted in our ability to cooperate. Since machines powered by artificial intelligence are playing an ever greater role in our lives, it will be important to equip them with the capabilities necessary to cooperate and to foster cooperation.
We see an opportunity for the field of artificial intelligence to explicitly focus effort on this class of problems, which we term Cooperative AI. The objective of this research would be to study the many aspects of the problems of cooperation and to innovate in AI to contribute to solving these problems. Central goals include building machine agents with the capabilities needed for cooperation, building tools to foster cooperation in populations of (machine and/or human) agents, and otherwise conducting AI research for insight relevant to problems of cooperation. This research integrates ongoing work on multi-agent systems, game theory and social choice, human-machine interaction and alignment, natural-language processing, and the construction of social tools and platforms. However, Cooperative AI is not the union of these existing areas, but rather an independent bet about the productivity of specific kinds of conversations that involve these and other areas. We see opportunity to more explicitly focus on the problem of cooperation, to construct unified theory and vocabulary, and to build bridges with adjacent communities working on cooperation, including in the natural, social, and behavioural sciences.


Numerical modelling has become established as an important tool for understanding ice sheet dynamics in general, and in particular for assessing the contribution of the Greenland and Antarctic ice sheets to future sea level change under global warming conditions. In this paper, we review related work carried out with the ice sheet model SICOPOLIS (SImulation COde for POLythermal Ice Sheets). As part of a group of eight models, it was applied to a set of standardised experiments for the Greenland ice sheet defined by the SeaRISE (Sea-level Response to Ice Sheet Evolution) initiative. A main finding of SeaRISE was that, if climate change continues unabatedly, the ice sheet may experience a significant decay over the next centuries. However, the spread of results across different models was very large, mainly because of differences in the applied initialisation methods and surface mass balance schemes. Therefore, the new initiative ISMIP6 (Ice Sheet Modeling Intercomparison Project for CMIP6) was launched. An early sub-project is InitMIP-Greenland, within which we showed that two different initialisations computed with SICOPOLIS lead indeed to large differences in the simulated response to schematic future climate scenarios. Further work within ISMIP6 will thus focus on improved initialisation techniques. Based on this, refined future climate simulations for the Greenland ice sheet, driven by forcings derived from AOGCM (atmosphere-ocean general circulation model) simulations, will be carried out. The goal of ISMIP6 is to provide significantly improved estimates of ice sheet contribution to sea level rise in the coming years.


The thesis project describes the analysis, process and major factors in development of a simple component oriented Web Shop in ASP.NET. It addresses to the concepts used in the application as well as derivation of technical design and development from the concepts acquired by studying existing approaches. The report describes a brief summary of existing approaches and related technologies. It also lays the foundation of goal oriented approach by providing an overview of component based software engineering. The basic concepts for modularization were barrowed from entities identification, object models and component models pplication's architecture is set to be a layered app roach combining the software layered architecture approach with multi tier architecture of web applications. Class models explaining the inner structure of each component have been provided and an overview of user interface pages is given to explain the application outer flow. The application sets out to prove the significance of component oriented approach as well as the support provided for it by ASP.Net. The resulting package proves to have scalable components that could be scaled for or reused in another application or in a later version of the same application.


Biometrics gives a lot of methods in high-secure applications while using natural, user-friendly and fast authentication. Cryptography is intended to ensure the secrecy and authenticity of message. The cryptographic key will be long, so it is difficult to remember, protecting the confidentiality of the cryptographic keys is one of the significant issues to be deal with. This can be efficiently solved by the integration of biometrics with cryptography. Conventional techniques depend on biometric features like face, fingerprint, hand geometry, iris, signature, keystroke, voice and the like for the extraction of key. Instead of storing key we will generate the key dynamically with the help of biometrics. Here we will use Finger print to generate key, which is safe and fast. This key can be used for any type of cryptography.


We propose two experimental schemes for concentrating entanglement in unknown partially entangled three-photon W states with only linear optical elements and the conventional photon detectors. We first propose a heralded scheme using a heralded controlled-NOT (CNOT) gate between two photons. Then we simplify this method to a post-selected one requiring time entanglement of the input photons without using ancillary photons. In the two schemes, Alice, Bob, and Charlie at three distant parties can obtain one maximally entangled three-photon W state from two identical partially entangled three-photon W states, taking the specific form of α|H>|H>|V>+β(|H>|V>|H>+|V>|H>|H>), by local operations and classical communication. We discuss and consider the success probabilities and the practical realizations of the schemes.


This paper documents the market reaction to the introduction of the European Financial Stability Facility (EFSF) in 2010 and 2011. The effect on borrowing rates is ambiguous - Greece, Ireland, Portugal, Spain, Italy and Slovenia exhibit a decrease in rates on event days, the remaining Eurozone countries exhibit an increase. The sovereign CDS market shows that not all of the effect on rates can be attributed to the assumption of default risk. CDS spreads do not increase in the case of Germany, France, the Netherlands, and Finland, consistent with a moderate increase in riskless rates. However, the net effect on the value of all Eurozone debt is positive and amounts to EUR 108 billion. Market participants also seem to anticipate an impact on real economic conditions given that the increase in non-financial equity value is EUR 126 billion, or 1.4% of Eurozone GDP.


Subacute sclerosing panencephalitis (SSPE) is a progressive, fatal disease of the central nervous system caused by a persistent measles virus. It is clinically characterized by insidious onset of intellectual deterioration and behavioral changes followed by myoclonias and eventually complete neurologic deterioration. The diagnosis is based on characteristic clinical features, periodic electroencephalography (EEG) complexes of high slow waves and increased antibody titer against measles in cerebrospinal fluid. Here, we report four SSPE cases, two of whom manifested with hemiparesis; in the third and fourth cases, cerebellar ataxia and acute encephalopathy with focal seizures were the presenting symptoms at the onset of disease, respectively. The typical periodic EEG complexes in our patients led to the diagnosis of SSPE. Our findings show that SSPE should be considered in the differential diagnosis of hemiparesis, cerebellar ataxia and acute encephalopathy, and highlight the diagnostic significance of EEG in unidentified cases.


Self-employment is becoming an increasingly viable option for growing numbers of young people entering the labour market, so it is important to identify and develop good practice in the delivery of entrepreneurship training. Not only will this enhance the quality of its provision, but it will also serve to ensure that the economic benefits from larger numbers of start-ups and innovatory new businesses are fully realised. The development and transfer of training in entrepreneurship are examined. Recent studies indicate that its provision at the tertiary education level boosts new business formation, and that experiential learning in entrepreneurship provides students with more incentives to start their own enterprises on graduating than formal enrolment in business programmes. These studies further suggest a strong positive correlation between those European universities that have adopted strategies, resources and institutional infrastructures explicitly targeted towards entrepreneurial objectives and the quality of their entrepreneurship training provision. On this basis, tertiary education institutions need to adopt a holistic cross-disciplinary approach, which commits them fully to promoting opportunities for training students in the formation of enterprises and the translation of innovatory ideas into operational businesses. To be effective, this should involve campus-wide provision, as well as outreach and engagement with the community and its businesses. Evidence demonstrates a number of alternative pathways for the transfer of good practice entrepreneurship training to less developed countries. Bottom-up models depend on the establishment of centres of excellence. These need to develop the capacity to engage with their own government policy-makers in shaping national training initiatives along their own good practice lines. Top-down models depend on creating a policy-framework and funding sources sufficient to encourage the adoption of effective entrepreneurship training programmes across the national educational framework. Here the crucial issue is the ability of existing institutions to respond to such opportunities. Between these extremes, the German dual VET system offers an 'off-the-shelf' option for the transfer of vocational entrepreneurship training to less developed countries, which still requires extensive adaptation to local conditions.


Abstract:This essay examines how Indigenous research methodologies can be usefully applied to medieval texts. It does this by recounting and engaging with personal experience and by interrogating how research is deployed for colonial purpose. The use of medieval English texts by early modern and later colonial proponents and apologists, particularly John Dee, emphasize the inherent colonial purpose of traditional research methodologies. These processes are contrasted with Indigenous research methodologies, particularly those proposed by Linda Tuhiwai Smith, and the author's own personal experience and that of his tribal nation of how Indigenous memory and inquiry can inform research practices that are relational and not exploitive.


PART ONE: LEADERSHIP THEORIES AND VALUES An overview of the leadership discourses - Simon Western From successful school leadership towards distributed leadership - Lejf Moos The nature and specialised purposes of educational leadership - Paul T. Begley Emotional intelligence, emotional labour and affective leadership - Sam Held and Judy McKimm PART TWO: STRATEGIC LEADERSHIP AND MANAGING CHANGE Concepts of leadership in organisational change - Gill Robinson Hickman The nature and dimensions of strategic leadership - Brent Davies and Barbara J. Davies The strategy lenses - Gerry Johnson, Kevan Scholes and Richard Whittington The practice of leadership in the messy world of organisation - Jean-Louis Denis, Ann Langley and Linda Rouleau PART THREE: LEADERSHIP IN CONTEXT Reframing the role of organisations in policy implementation: resources for practice, in practice - James P. Spillane, Louis M. Gomez and Leigh Mesler Contextualising leader dynamics: how public service leaders endeavour to build influence - Mike Wallace and Michael Tomlinson Stories of compliance and subversion in a prescriptive policy environment - John MacBeath Evaluation, accountability and performance measurement in national education systems: trends, methods and issues - Katherine E. Ryan and Irwin Feller 'Blended leadership': employee perspectives on effective leadership in the UK Further Education sector - David Collinson and Margaret Collinson Leadership for diversity and inclusion - Jacky Lumby PART FOUR: PARTNERSHIPS AND COLLABORATION Reconfiguring urban leadership: taking a perspective on community - Kathryn A. Riley Networks as power bases for school improvement - Tessa A. Moore and Michael P. Kelly Inter-professional work and expertise: new roles at the boundaries of schools - Anne Edwards, Ingrid Lunt and Eleni Stamou Approaches to system leadership: lessons learned and policy pointers - Beatriz Pont and David Hopkins PART FIVE: LOOKING TO THE FUTURE Leadership, participation and power in the school system - Richard Hatcher The fourth way - Andy Hargreaves and Dennis Shirley


This unique study offers a comprehensive analysis of American jurisprudence from its emergence in the later stages of the nineteenth century through to the present day. The author argues that it is a mistake to view American jurisprudence as a collection of movements and schools which have emerged in opposition to each other. By offering a highly original analysis of legal formalism, legal realism, policy science, process jurisprudence has evolved as a collection of themes which reflect broader American intellectual and cultural concerns.


In this paper we develop a framework for comparing ontologies, and place a number of the more prominent ontologies into it. We have selected 10 specific projects for this study, including general ontologies, domain specific ones, and one knowledge representation system. The framework includes general characteristics such as the purpose of an ontology, its coverage (general or domain-specific), its size, and the formalism used. It also includes the design process used in creating an ontology and the methods used to evaluate it. Characteristics that describe the content of an ontology include taxonomic organization, types of concepts covered, top-level divisions, internal structure of concepts, representation of part-whole relations, and the presence and nature of additional axioms. Finally we consider what experiments or applications have used the ontologies. Knowledge sharing and reuse will require a common framework to support interoperability of independently created ontologies. Our study shows there is great diversity in the way ontologies are designed and the way they represent the world. By identifying the similarities and differences among existing ontolo~ies, we clarify the range of alternatives in creating a standard framework for ontology design.


Background: It is not known whether the age of acquisition (AoA) of a word has any significant effect on the spelling performance of normal or impaired speakers. One way to explore this question is to examine the effects of AoA on surface dysgraphia. Aims: We report MK, a patient who suffered herpes simplex viral encephalitis (HSVE) resulting in semantic anomia and surface dysgraphia that we characterise as a tendency to produce a legitimate alternative spelling of a component defined as a LASC error. Methods & Procedures: We describe MK's neuropsychological profile, giving details of impaired naming, spoken and written word comprehension, written picture naming, oral reading, and spelling to dictation, but preserved repetition of whole words. We report experiments designed (1) to test the effect of AoA on spelling by controlling for word frequency as well as other correlated variables using logistic regression and ANOVA, and (2) to test the effects of AoA and sound to spelling predictability on MK's spelling. Outcomes and Results: The results show an effect of AoA but no independent effect of frequency on spelling and an interaction between AoA and predictability, i.e., an effect of AoA on unpredictable word spelling but no effect of AoA on predictable word spelling. Conclusions: We discuss these data with reference to accounts of AoA that locate the effect at the level of mappings between input (phonological) and output (orthographic) representations. We argue that the effect of AoA on spelling is not the result of lexeme activation per se but instead reflects the largely unpredictable mappings between sound and spelling that characterise the majority of English word spellings.