The central thesis around which several arguments develop and revolve in
this work is that time has come for members of the legal profession in Botswana,
Lesotho and Swaziland - countries with shared historical, cultural, legal and socioeconomic
values - to join other forces in assessing both their structures and
functions with a view to readjusting them to suit the new demands of society, namely
that even under those new conditions, legal services must not only be available but
must be competently delivered to the public. To be responsive to the needs of
society, lawyers must be trained in such a way that they are able to appreciate the
importance of social goals and contribute to the full satisfaction of those goals with
competence and efficiency.
In advancing the above thesis three methods are employed. Firstly, is to
establish the present and future needs of the society and how these needs can be
met in terms of the necessary requirements of law, lawyers and the entire legal
process to satisfy those needs. Secondly, to establish the extent to which those
needs have and are being met and to explain the reasons for the limitation in their
success. Thirdly, to advance the theory that legal education has a task in
transforming society by equipping students with highly developed skills needed to
bring about people-centred development.
The object of the thesis is, therefore, to develop and explore through
empirical research new avenues of development-oriented legal education by
analysing the sources and magnitude of the problem of legal education; by
examining the social context in which law, lawyers and the entire legal process
operate; by exploring all factors, legal and non-legal, which limit law, lawyers and
legal institutions, including legal education in their role to meet the needs of society
and by developing a skills-oriented legal education which would produce lawyers
much needed for development within the context of Botswana, Lesotho and
Swaziland.
To that end the work is divided into ten chapters discussing, amongst others,
the objectives and methodology employed in the research; the concept of
development and the limitations of lawyers in that development process as
evidenced by the socio-political economy of the BOLESWA countries; the legal
needs and the utilisation of lawyers to meet those needs in Swaziland; and the
extent to which the past and present law programmes adequately prepare lawyers to
satisfy social needs. It ends by providing a few suggestions. However, central to
the entire discussion is the development of a fresh model in legal education that
emphasises skills development as the most appropriate for development-oriented
lawyers needed today in the BOLESWA countries. In one's research in legal
education, one is struck by lack of sufficient work in this area. Yet legal education is
at a crossroad of its development in the BOLESWA countries where crisis of law
and development occupy central themes in scholarly debates currently taking place.
If significant changes are to be effected, the arguments on skills development
presented in this thesis remain critically important for future debates, policy
formation and implementation on the subject in the BOLESWA countries and
Southern Africa generally.


Despite impressive results, deep learning-based technologies also raise severe privacy and environmental concerns induced by the training procedure often conducted in data centers. In response, alternatives to centralized training such as Federated Learning (FL) have emerged. Perhaps unexpectedly, FL in particular is starting to be deployed at a global scale by companies that must adhere to new legal demands and policies originating from governments and the civil society for privacy protection. However, the potential environmental impact related to FL remains unclear and unexplored. This paper offers the first-ever systematic study of the carbon footprint of FL. First, we propose a rigorous model to quantify the carbon footprint, hence facilitating the investigation of the relationship between FL design and carbon emissions. Then, we compare the carbon footprint of FL to traditional centralized learning. Finally, we highlight and connect the reported results to the future challenges and trends in FL to reduce its environmental impact, including algorithms efficiency, hardware capabilities, and stronger industry transparency.


A xenolith made of exceptionally Cr-rich minerals (mostly omphacite, kyanite and minor rutile) has been found in the diamondiferous Mbuji-Mayi kimberlite province, Democratic Republic of Congo (DRC). Chromium contents (Cr2O3) are heterogeneously distributed in the bulk sample, as well as in a single crystal: 3.34–5.70 wt% in omphacite, 4.45–11.81 wt% in kyanite and 2.68–4.65 wt% in rutile. Such Cr-rich kyanite is extremely rare; only grospydite xenoliths from the Zagadochnaya kimberlite (Yakutia) have been reported with kyanite containing up to 12.86 wt% Cr2O3. However, unlike typical grospydites, no garnet is observed in the Mbuji-Mayi Cr-rich kyanite-bearing clinopyroxenite. The textural features of this rock and the tentative thermobarometric equilibration conditions (25–35 kbar, 700–800 C) argue for an origin related to that of eclogites, which are the predominant xenoliths in the Mbuji-Mayi kimberlites. The calculated whole-rock composition suggests an Al-, Caand Cr-rich protolith that resembles Cr-rich leucogabbros or anorthosites commonly found in Archean anorthosite massifs. The peak P-T conditions registered by this unusual rock can be reached either by Archean subduction or by mafic magma underplating at the crust-to-mantle boundary with subsequent delamination into the upper mantle. Key-words: kyanite clinopyroxenite, chromium-rich, Mbuji-Mayi, kimberlite, xenolith, Kasai-Lomami Complex, eclogite.


Concerns about the veracity of psychological research have been growing. Many findings in psychological science are based on studies with insufficient statistical power and nonrepresentative samples, or may otherwise be limited to specific, ungeneralizable settings or populations. Crowdsourced research, a type of large-scale collaboration in which one or more research projects are conducted across multiple lab sites, offers a pragmatic solution to these and other current methodological challenges. The Psychological Science Accelerator (PSA) is a distributed network of laboratories designed to enable and support crowdsourced research projects. These projects can focus on novel research questions or replicate prior research in large, diverse samples. The PSA's mission is to accelerate the accumulation of reliable and generalizable evidence in psychological science. Here, we describe the background, structure, principles, procedures, benefits, and challenges of the PSA. In contrast to other crowdsourced research networks, the PSA is ongoing (as opposed to time limited), efficient (in that structures and principles are reused for different projects), decentralized, diverse (in both subjects and researchers), and inclusive (of proposals, contributions, and other relevant input from anyone inside or outside the network). The PSA and other approaches to crowdsourced psychological science will advance understanding of mental processes and behaviors by enabling rigorous research and systematic examination of its generalizability.


We find that free-floating planets can remain bound to a star cluster for much longer than was previously assumed: of the order of the cluster half-mass relaxation timescale as opposed to the crossing-time. This result is based on N-body simulations performed with the new GRAPE-6 special purpose hardware and is important in the context of the preliminary detection of a population of free-floating sub-stellar objects in the globular cluster M22. The planets in our N-body study are of Jupiter mass and are initially placed in circular orbits of between 0.05 and 50 AU about a parent star whose mass is chosen from a realistic initial mass function. The presence of the free-floating planets is the result of dynamical encounters between planetary systems and the cluster stars. Most planets are liberated from their parent star in, or near, the cluster core, and then drift outwards on a timescale of ~ 10^{8-9} year. This still implies the existence of many (~100) planets per star if the M22 result is confirmed.


Fall seeding of canola can increase equipment and manpower efficiencies for producers, hasten crop maturity, and improve seed quality, but no previous studies have examined effects of this practice on infestations of flea beetles (Phyllotreta spp.) (Coleoptera: Chrysomelidae), the major pests of crop seedlings in North America. Field experiments were conducted at Vegreville, Fort Saskatchewan, and Lethbridge, AB, Canada from 1998 through 2000 to determine the effect of fall versus spring seeding of canola (Brassica napus L. and Brassica rapa L.) on feeding damage by flea beetles. Interactions with seeding rate and seed treatment on flea beetle damage also were investigated. Flea beetle damage was greater on plants of B. rapa than B. napus, on spring-seeded canola than on plants seeded in fall, and on plants that developed from seed treated with Vitavax Single (containing carboxin) than on plants treated with Vitavax rs (containing carboxin, thiram, and lindane). Mean flea beetle damage per plant declined with an increase in seeding rate. Canola seeded in fall reached 50% flowering about 10 d earlier than plants seeded in April and about 20 d before plants seeded in May. Fall-seeded plants matured 5 to 21 d earlier than plants seeded in April and about 10 to 30 d before plants seeded in May. Seeding in fall enabled plants to progress beyond the vulnerable cotyledon stage by the time that most flea beetle injury occurred. Seeding canola in fall, at rates selected to achieve vigorous plant stands, is an important component of an integrated management strategy for flea beetles, with the potential for substantially reducing insecticide -use in this crop.


During the 2013 Muzaffarnagar communal riots, in which over sixty people died and thousands were displaced, social media was reported to have played a significant role in spreading rumors and propaganda. In this context, an incendiary video of two men being beaten to death, described (incorrectly) as a video of Hindus being lynched by a Muslim mob was circulated on the Internet. Similarly, a Muslim man was killed by a mob in Pune following the circulation of morphed images denigrating iconic leader attributed to him. These images were circulated on Facebook and through Internet messaging applications on smartphones.State governments in India have taken to disabling Internet services, especially mobile data services, in response to threats of violence. For example, in June 2016, the Indian government shut down the Internet in the state of Haryana, fearing potential violence arising from ongoing protests. Internet shutdowns are becoming commonplace – there have been thirty-nine incidents since January 2015. The alleged reasons for the shutdowns ranged from apprehensions about provocative social media rumors related to the recovery of cow carcasses to the prevention of cheating during a public government-administered exam. Many of these justifications offered for Internet shutdowns fall within the umbrella of online hate speech or incitement to violence.Hate speech is a serious concern in the Republic of India. However, Indian law does not use the phrase "hate speech." Different forms of what may arguably be called hate speech are covered in different ways by various Indian statutes.This briefing paper outlines preliminary issues that we noted while conducting a detailed study of hate speech laws in India. It teases out some of the major concerns that arise in the context of both online and offline hate speech, especially speech as potential incitement to violence. Our upcoming detailed report covers a wider range of what might be called hate speech, and extends to speech that may not act as potential incitement to violence. The report offers a more nuanced and detailed picture of the current state of affairs, as well as the conclusions drawn and recommendations made.


Purpose - With increasing exposure to disruptions, it is vital for supply chains to manage the risks proactively. Prediction of potential failure points and overall impact of these risks is challenging. In this paper, systems thinking concepts are applied for modelling supply chain risks. The aim of this research is to develop a holistic, systematic and quantitative risk assessment process for measuring the overall risk behaviour.Design/Methodology/Approach - A framework for Supply Chain Risk Management (SCRM) is developed and tested using an industrial case study. A systematically developed research design is employed to capture the dynamic behaviour of risks. Additionally, a system based supply chain risk model is conceptualized for risk modelling. Sensitivity modelling results are combined for validating the supply chain risk model. Findings - The systems approach for modelling supply chain risks predicts the failure points along with their overall risk impact in the supply chain network. System based risk modelling provides a holistic picture of risk behavioural performance which is difficult to realise through other research methodologies commonly preferred in the SCRM research. Practical Implications - The developed framework for SCRM is tested in an industry setting for its viability. The framework for SCRM along with the supply chain risk model is expected to benefit practitioners in understanding the intricacies of supply chain risks. The system model for risk assessment is a working tool which could provide a perspective of future disruptive events.Originality - A holistic, systematic and quantitative risk modelling mechanism for capturing overall behaviour of risks is a valuable contribution of this research. The paper presents a new perspective towards using systems thinking for modelling supply chain risks.


This thesis project aimed to fractionate cornstalk into cellulose and lignin, and utilize the crude cornstalk-derived cellulose for the production of sodium carboxymethyl cellulose and the lignin for the sybthesis of bio-based phenol-formaldehyde resole resins as wood adhesives. In this thesis work, cornstalk was efficiently fractionated into crude cellulose and crude lignin in mixed solvents of acetic acid, formic acid and water at a solid/agent ratio of 1:5 (g/mL) at 80-100 °C for 120-240 min. The best conditions for organosolv fractionation of cornstalk among the test conditions were determined as follows: mixed solvent of acetic acid/formic acid/water (3:6:1, v/v/v), HCl as the catalyst, 90 °C and 180 min residence time, where the yield (and purity) of crude cellulose and lignin products were approximate 53% (85%) and 38% (44%), respectively, on the basis of mass of oven-dried cornstalk, and the obtained crude cellulose products have very low residual lignin contents (<4%). The crude cellulose fractionated from cornstalk was further used, after bleaching, as feedstock for the synthesis of sodium carboxymethyl cellulose (CMC). The best molar ratio of the reaction reagents (NaOH/ClCH2COOH /cellulose) among the test conditions were investigated and determined to be 4.0:2.5:1 and 4.6:2.8:1, or the molar ratio of NaOH/ClCH2COOH being 1.6-1.64. The CMC products obtained at the best reactants molar ratios have relatively high water solubility and reasonably high viscosity and molecular weights. The average degree of substitution (DS) of these two CMC products obtained at the best molar ratios among the test conditions are 0.57 and 0.85, respectively.


Historically, three species of freshwater fishes have been recorded from Lord Howe Island, Longfin Eel, Anguilla reinhardtii, Southern Shortfin Eel, Anguilla australis and Common Galaxias, Galaxias maculatus. Both eel species are widespread throughout the island. The Common Galaxias was collected in 1889 (Australian Museum record) and 1962 (Allen et al., 1976). In 1989, Common Galaxias was recorded in the lagoon seaward of Soldiers Creek by Ian Hutton (pers. comm.). During the Australian Museum Expedition in 2017, both eel species were recorded however Common Galaxias were not found. Sampling for fishes was conducted in all known freshwater creeks and drainages on the Island, except for Erskine Valley and an unnamed creek on the eastern side of Mt Lidgbird.


In order to facilitate the rapid development of B2B e-business and supply chain, many industry consortia develop industry-specific standards. This paper differentiates between two distinct dimensions characterizing organizations' standards use: breadth and depth. We examine how industry consortia' promotion strategies influence the breadth and depth of standards use, and how standards use influences adaptive knowledge creation. We also examine how firm size moderates the relationship between promotion strategies and standards use. The hypotheses are tested using survey data collected from organizations in China who have implemented RosettaNet standards. The empirical results show that relationship, policies, and technology strategies significantly affect standards use, and firm size moderates the influence. Further, only the depth of standards use influence adaptive knowledge creation.


To improve the ecological functioning of riverine ecosystems, large‐scale floodplain rehabilitation has been carried out in the Rhine–Meuse Delta since the 1990s. This paper evaluates changes in abundance of 93 breeding bird species over a period of 10 years in response to rehabilitation, by comparing population changes in 75 rehabilitated sites with 124 non‐rehabilitated reference sites. Such quantitative, multi‐species, large‐scale and long‐term evaluations of floodplain rehabilitation on biodiversity are still scarce, particularly studies that focus on the terrestrial component. We try to understand the effects by relating population trends to ecological and life‐history traits and strategies of breeding birds. More specifically, we try to answer the question whether rehabilitation of vegetation succession or hydro‐geomorphological river processes is the key driver behind recent population changes in rehabilitated sites. Populations of 35 species have significantly performed better in rehabilitated sites compared to non‐rehabilitated floodplains, whereas only 8 have responded negatively to rehabilitation. Differences in effects between species are best explained by the trait selection of nest location. Reproductive investment and migratory behaviour were less strong predictors. Based on these three traits we defined eight life‐history strategies that successfully captured a substantial amount of variation in rehabilitation effects. We conclude that spontaneous vegetation succession and initial excavations are currently more important drivers of population changes than rehabilitation of hydrodynamics. The latter are strongly constrained by river regulation. If rehabilitation of hydro‐geomorphological processes remains incomplete in future, artificial cyclic floodplain rejuvenation will be necessary for sustainable conservation of characteristic river birds. Copyright © 2010 John Wiley & Sons, Ltd.


Two automatic measurement methods of bidirectional reflection distribution function (BRDF) are presented based on absolute and relative definition. Measurement principle and scheme of the methods are analyzed. A real-time measurement device is developed, the measurement spectral range of which is from ultraviolet to near infrared with 2.4-nm wavelength resolution, and the angular range is [EQUATION] in azimuth angle and [EQUATION] in zenith angle with [EQUATION] angle resolution. Absolute measurements of BRDF on tinfoil and ceramic tile are performed and the test materials present apparent specular reflection characteristics. The theoretical error in the experiment is about 6.05%. The BRDF measurement results are closely related to the precision of measurement platform, the sensitivity of measurement instrument, and the stability of illuminating light source.


Lipiophilic dyes such as Laurdan and Prodan are widely used in membrane biology due to a strong bathochromic shift in emission that reports structural parameters of the membrane such as area per molecule. Disentangling the factors which control the spectral shift is complicated by the stabilization of a charge-transfer-like excitation of the dye in polar environments. Predicting the emission therefore requires modeling both the relaxation of the environment and the corresponding evolution of the excited state. Here an approach is presented in which (i) the local environment is sampled by classical molecular dynamics (MD) simulation of the dye and solvent; (ii) the electronically excited state of Prodan upon light absorption is predicted by numerical quantum mechanics (QM); (iii) iterative relaxation of the environment around the excited dye by MD coupled with evolution of the excited state is performed; (iv) the emission properties are predicted by QM. The QM steps are computed using many-body Green's function in the $GW$ approximation and the Bethe-Salpeter Equation with the environment modeled as fixed point charges, sampled in the MD simulation steps. Comparison to ultrafast time resolved transient absorption measurements demonstrates that the iterative MM/QM approach agrees quantitatively with both the polarity dependent shift in emission and the timescale over which the charge transfer state is stabilized. Together the simulations and experimental measurements suggest that evolution into the charge-transfer state is slower in amphiphilic solvents.


Despite his importance as a senior Al-Qaeda spokesman, no detailed examination exists of Adam Yahiye Gadahn's employment of fiqh al-jihad—that branch of Islamic jurisprudence regulating the lawful waging of jihad—to condemn or condone violence committed in the name of Al-Qaeda. This article first provides a detailed exposition of Gadahn's sharia-based critique of affiliates' conduct deemed by him in violation of Islamic law and involving the commission of major sins. Second, Gadahn's conception of fiqh al-jihad is contextualized and contrasted with the comprehensive fiqh al-jihad-based critiques produced by respected militant Islamist scholars. A key finding here is that Gadahn (unlike these scholars) illicitly truncates the application of fiqh al-jihad with the result that he demands sharia-compliance when criticizing intra-Islamist violence yet ignores sharia-compliance when targeting America and Americans. Third, reasons are considered for this incoherent application of fiqh al-jihad and attempted Islamic legalization of anti-American mass casualty terrorist attacks. Finally, the discussion concludes with implications for counter-Al-Qaeda strategy.


INTRODUCTION
The accurate categorization of drugs is a prerequisite for decision support rules. The manual process of creating drug classes can be laborious and error-prone.

METHODS
All 142 drug classes currently used at Regenstrief Institute for drug interaction alerts were extracted. These drug classes were replicated as fully-defined concepts in our local instance of the NDFRT knowledge base. The performance of these two strategies (manual classification vs. NDFRT-based queries) was compared, and the sensitivity and specificity of each was calculated.

RESULTS
Compared to existing manual classifications, NDFRT-based queries made a greater number of correct class-drug assignments: 1528 vs. 1266. NDFRT queries have greater sensitivity (74.9% vs. 62.1%) to classify drugs. However, they have less specificity (85.6% vs. 99.8%).

CONCLUSION
The NDFRT knowledge base shows promise for use in an automated strategy to improve the creation and update of drug classes. The chief disadvantage of our NDFRT-based approach was a greater number of false positive assignments due to the inclusion of non-systemic doseforms.


Effolts to mitigate wildlife-human conflicts tpically involve management of unacceptably abundant populations. Increasingly, however, reduction of dense or increasing populations of certain wild species evokes both support and contention kom the public. Management decisions involving population reduction, particularly those directed at highly visible species, should therefore be based on quantitative evaluation of potential outcomes prior to implementation. The purpose of th~s paper is to revisit a call for use of population modeling in management decisions by reviewing basic aspects of population analysis and the use of publicly available long-term data sets in environmental assessments and impact statements. Our objectives are to discuss I) the relationship of population parameters to population growth, 2) methods of population projection, 3) use of data for model calibration and validation, and 4) the evaluation of management scenarios. Justification and defense of lethal or reproductive conhol programs to solve vertebrate pest problems requires a sound understanding of population status and the dynamics of the problem species.


'Dammed taxi cab' – a 12-year-old boy wrote these words in the margins of a questionnaire, and within this paper they will serve as a point of departure for the discussion of the use of questionnaires as a way to voice children's experiences. The overall aim of this paper is to enable understanding of and discuss the use of questionnaires as a way to voice children's experiences. An analysis in accordance with a life-world approach has provided the lens through which to explore messages that can occur in questionnaires. The key research questions that will be explored in an attempt to answer the overall aim are: (i) how can unanswered questions and notes in the margins of a questionnaire be understood? and (ii) why is a questionnaire not always completed, according to the intention of its creators? To develop an understanding of this we analysed a number of questionnaires with unanswered questions and notes in the margins using a life-world approach. During the analysis two themes emerged: silent messages and messages being silenced. Finally, we discuss the legitimacy of questionnaires in childhood research and possible implications for practice when using this method to give voice to children's experiences.


The event-related potential (ERP) technique in cognitive neuroscience allows scientists to observe human brain activity that reflects specific cognitive processes. In An Introduction to the Event-Related Potential Technique, Steve Luck offers the first comprehensive guide to the practicalities of conducting ERP experiments in cognitive neuroscience and related fields, including affective neuroscience and experimental psychopathology. The book can serve as a guide for the classroom or the laboratory and as a reference for researchers who do not conduct ERP studies themselves but need to understand and evaluate ERP experiments in the literature. It summarizes the accumulated body of ERP theory and practice, providing detailed, practical advice about how to design, conduct, and interpret ERP experiments, and presents the theoretical background needed to understand why an experiment is carried out in a particular way. Luck focuses on the most fundamental techniques, describing them as they are used in many of the world's leading ERP laboratories. These techniques reflect a long history of electrophysiological recordings and provide an excellent foundation for more advanced approaches. The book also provides advice on the key topic of how to design ERP experiments so that they will be useful in answering questions of broad scientific interest. This reflects the increasing proportion of ERP research that focuses on these broader questions rather than the "ERPology" of early studies, which concentrated primarily on ERP components and methods. Topics covered include the neural origins of ERPs, signal averaging, artifact rejection and correction, filtering, measurement and analysis, localization, and the practicalities of setting up the lab.


The research uses both qualitative and quantitative methodologies employing multiple sources of data collection. Quantitative data collection used a survey of primary schools in two English Local Authorities. The qualitative evidence of the teacher sample was through individual semi-structured interviews and a focus group interview of Local Authorities officers. There is an evidence trail which examines conference papers, HMI, QCA, Ofsted and DfES reports. The main findings indicate that teachers were becoming familiar with the use of computers. They understood the skills involved in using computers but were still uncertain as to a suitable pedagogy. The New Opportunities Funding (NOF) training was reported as being a disappointment due to its over-ambitious aims and lack of pedagogical content. Teachers involved in the study are finding it difficult to find time to either keep pace or develop their ICT skills.


The ongoing community-based research project that we describe in this article will contribute, we hope, to an understanding of the fringe economy by offering insights into what remains "unexplained" in the current existing literature, namely the gender and race disparities relating to who uses "alternative financial service" (AFS) products. This article likewise contributes to a growing body of literature within Critical Race Theory and Critical Race Feminism that deals with economic inequalities and how they are inextricably and structurally linked to race and gender subordination. By explicitly incorporating "participatory action research" (PAR) values and methods into our work as critical race/feminist scholars and researchers, we offer in this article a "new" way of doing critical race/feminist work that is designed specifically to enable likeminded legal scholars to "get out of [the ivory tower]...and hear from people firsthand." Our PAR intervention puts the voices and concerns of community stakeholders and research partners at the center of the work itself. Thus, our approach, which we call legal PAR, makes its most significant and original contribution to the existing legal scholarship by not only "looking to the bottom" in a theoretical sense, but also by treating those "at the bottom" as equal research partners who are presumptively best situated to identify, analyze, and solve problems that directly affect them.The article presents an overview of some recent empirical studies on those most likely to use "alternative financial services," also known as the "unbanked" and "underbanked." It also discusses and critiques the relevant legal literature on fringe banking and the unbanked and underbanked, and highlights some organizational efforts that aim not only to protect the unbanked and underbanked from predatory lending practices, but also seek to encourage and facilitate more responsible lending practices and innovations. The article introduces PAR, including its origins and critical developments, specifically highlighting the ways in which feminism, intersectionality, and CRT have and are continuing to impact the field. Finally, the article makes the case that PAR has much to offer legal scholars and scholarship while also setting forth some challenges — and resulting benefits — of doing legal PAR.


Aim/Purpose: This qualitative case-study explores how a doctoral student's family influences the doctoral student's success from the perspective of doctoral students who were enrolled in an online doctoral program.

Background: Previous research has shown that family can significantly influence doctoral student success; however, it is not clear what is meant by family nor what the details of the influence of family look like from the perspective of the doctoral student.

Methodology: A qualitative case-study method was used. More than 500 former students enrolled in an online doctoral program were emailed a web-based survey that elicited information about who they considered to be in their family, how they thought their relationship with their family changed while they were a doctoral student, and how much they thought their family understood what it means to be a doctoral student. One hundred thirty-three (24%) former students participated in the study. Qualitative data were analyzed both manually and electronically by three researchers who subsequently triangulated the data to confirm themes.

Contribution: This study defines 'family' from the doctoral student perspective and provides an in-depth look at how family influences doctoral student success including explanation of family support and lack thereof that previously has been shown to be significant to facilitating or hindering doctoral student success.

Findings: Doctoral students mostly considered their immediate and extended family (i.e., spouses, significant others, children, grandchildren, parents, grandparents, grandchildren, nieces, nephews, and parents-in-law) to be family, but some considered friends and coworkers to be part of their family as well. Most doctoral students experienced positive family support, but for those who did not, two major themes emerged as problematic: a reduction in the amount of time spent with family and family not understanding the value of earning a doctoral degree.

Recommendations for Practitioners: Institutions of higher education should consider these findings when creating interventions to increase retention of doctoral students. Interventions might include orientation programs to help family members understand the value of earning a doctoral degree, the time commitment necessary to complete a doctoral degree, and ways to support a family member earning a doctoral degree.

Recommendation for Researchers: The findings inform future research by surfacing more specific information about what family support and lack thereof looks like for doctoral students and what interventions for improving family support might include.

Impact on Society: Improving family support may improve doctoral student success by adding more doctoral-trained leaders, innovators, scholars, and influential educators to society and by supporting the financial investment of students and their families by decreasing attrition.

Future Research: Future research should focus on creating quantitative instrumentation to measure the influence of family on doctoral student success. Student populations from different types of doctoral programs (e.g., PhD, MD, DO) might be studied as well. Interventions aimed at improving family support should be designed, implemented, and evaluated for effectiveness.


A collection ${\cal P}$ of phylogenetic trees is compatible if there exists a single phylogenetic tree that displays each of the trees in ${\cal P}$. Despite its computational difficulty, determining the compatibility of ${\cal P}$ is a fundamental task in evolutionary biology. Characterizations in terms of chordal graphs have been previously given for this problem as well as for the closely-related problems of (i) determining if ${\cal P}$ is definitive and (ii) determining if ${\cal P}$ identifies a phylogenetic tree. In this paper, we describe new characterizations of each of these problems in terms of edge colourings. Furthermore, making use of the tools that underlie these new characterizations, we also determine the minimum number of quartets required to identify an arbitrary phylogenetic tree, thus correcting a previously published result.


Recent advances in our understanding of the basic mechanisms that control liver regeneration and repair will produce the next generation of therapies for human liver disease. Insights gained from large‐scale genetic analysis are producing a new framework within which to plan interventions. Identification of specific molecules that drive regeneration will increase the options for live‐donor liver transplantation, and help treat patients with small‐for‐size syndrome or large tumors who would otherwise have inadequate residual mass after resection. In a complementary fashion, breakthroughs in the ability to manipulate various cell types to adopt the hepatocyte or cholangiocyte phenotype promise to revolutionize therapy for acute liver failure and metabolic liver disease. Finally, elucidating the complex interactions of liver cells with each other and various matrix components during the response to injury is essential for fabricating a liver replacement device. This focused review will discuss how a variety of important scientific advances are likely to impact the treatment of specific types of liver disease.


A spectral analysis of the Australian time series for the investment and savings ratios on quarterly data over the period from September 1959 to December 2005 reveals that the major cyclical components of the savings and investment ratios cohere strongly. This suggests there is a medium to long term relationship between investment and savings. Further, the investment and saving ratios cohere strongly with the business cycle suggesting a procyclical pattern of investment and saving behaviour on Australian data. A subsequent long memory analysis reveals that the saving and investment ratios, the investment ratio and real GDP and the savings ratio and real GDP are fractionally cointegrated. The policy implications are explained.


Multi-Layer Ceramic Capacitors (MLCCs) are key passive components in modern electronics. MLCCs consist of alternating metal electrode and ceramic dielectrics layers. In ultrathin MLCC chips, the micrometric layers are composed of submicrometric metal and ceramic powders and nano sized ceramic additives (to retard the sintering of electrode and minimize the sintering mismatch). A number of defects such as cracks, delamination of layers and electrode discontinuity and homogeneity, may arise in the processing of these ultrathin MLCCs. The cracks and delamination result in product rejection. Electrode discontinuities (uncovered areas) and thickness homogeneity generate a number of problems including capacitance loss, electrical short, leakage current and decreased reliability.
It is generally recognized that these defects are linked to the sintering kinetics mismatch between electrode and dielectric materials, during the co-firing (co-sintering) process of MLCCs. However, when it comes to the origin of these defects and to their evolution during the sintering process, little knowledge is available. Conventional post-sintering and 2-dimensional (2D) imaging methods suffer limitations.
In this context, in-situ synchrotron X-ray imaging and Discrete Element Method (DEM) have been carried out to explore the origin and the evolution of defects during the co-sintering process. X-ray imaging including 2D radiography and 3-dimensional (3D) nano computed tomography (X-ray nCT) enable non-destructive in-situ observation of the microstructure change in 2D and 3D. In parallel, DEM can simulate the sintering of MLCCs by taking into account the powders' particulate nature (particle size, packing, etc.)
Synchrotron (Advanced Photon Source, Argonne National Laboratory, IL, USA) X-ray based Transmission X-ray Microscope (TXM) with spatial resolution of 30 nm was used to characterize a representative cylindrical volume of O 20 µm × 20 µm extracted from a 0603 (1.6 mm×0.8 mm) case size Nickel (Ni)-electrode Barium Titanate (BaTiO3, or BT)-based MLCC before and after sintering under 2H2%+Ar atmosphere. 3D tomographic microstructure imaging shows that the final electrode discontinuity is linked to the initial heterogeneity in the electrode layers. In situ X-ray radiography of sintering (heating ramp of 10 oC, holding at 1200 oC for 1 hour, cooling ramp -15 oC) of a Palladium (Pd) electrode BNT (Barium-neodymium-titanate) based MLCC representative volume was also carried out. It confirmed that discontinuities in the electrode originate from the initial heterogeneities, which are linked to the very particulate nature of the powder material. The discontinuity occurs at the early stage of the sintering cycle. At this stage, the electrode starts to sinter while the dielectric material may be considered as a constraining substrate.
Correlative studies using Focused Ion Beam - Scanning Electron Microscope (FIB - SEM) tomography were conducted on green and sintered MLCC samples at high resolution (5 × 5 × 5 nm3). FIB images confirmed that the resolution of the X-ray nCT is sufficient to deal with these heterogeneity evolutions. Still, FIB tomography allows the X-ray nCT to be re-interpreted more accurately. Also, it provides detailed particulate parameters for the DEM simulations.
The DEM was used to simulate the microstructure of a multilayer system during sintering. These simulations operate at the particle length scale and thus recognize the particulate nature of the multilayers at the early stage of sintering. First, the sintering of Ni matrix with BT inclusions was simulated using the dp3D codes (developed at SIMaP/GPM2, Universite de Grenoble, France). The retarding effect of BT inclusions on the sintering of Nickel matrix was predicted by varying the size, the amount and the homogeneity of inclusions. It is found that the densification rate of the matrix decreases with increasing volume fraction of inclusions and with decreasing size of inclusions. For a given volume fraction and size of inclusions, a better dispersion of the inclusions results in a stronger retardation of the densification kinetics of the nickel matrix.
Co-sintering of BT/Ni/BT multilayers was simulated with DEM by taking into account the particulate nature collected from the high resolution FIB nanotomography (FIB-nT) data, such as particle size, size distribution, heterogeneities, pores, and geometry. The temperature profile was also reproduced in these simulations. It is found that the electrode discontinuities originate from the initial heterogeneities in the green compact and form at the early stage of sintering under constraint, in good correspondence to the experimental observations. Parametric studies suggest that electrode discontinuities can be minimized by homogenizing the packing density and thickness of the electrodes and using a fast heating rate.
Based on both experimental and DEM simulation results, a general conclusion is reached: the final discontinuity originates from the initial heterogeneity in the electrode layers and occurs at the early stage of sintering when the dielectric layers constrain the electrode layers.
A defect evolution mechanism is proposed: after the lamination of BT sheets, there exist inevitably heterogeneous regions in the electrodes. Below 950-1000 oC, the nickel powder densifies except in heterogeneous zones for which desintering has been observed. At this stage, the Ni layers are under tensile stress. Tensile stresses in the thinner sections induce matter flow towards the thicker sections until the thinner sections are disrupted and discontinuities form. Once nickel is fully dense, electrodes are subjected to compressive stress at high temperature (1100 oC) due to BT densification. The compressive stress causes contraction of the viscous nickel, resulting in swelling of electrodes and hence a further increase in electrode discontinuity. Meanwhile, the nano-sized BT additives are expelled due to their unwettability with Ni at high temperature. The aggregated BT additives sinter, possibly forming percolation between two adjacent BT layers and enhancing the mechanical adhesion between Ni and BT layers in the MLCCs.


The Supplemental Security Income (SSI) program is the nation's safety net for the aged, blind, and disabled. SSI receipt is often not reported by individuals interviewed in the Current Population Survey (CPS), the statistical base for the Census Bureau's annual estimates of poverty rates. In an earlier article, we explored the effect on estimated poverty rates in 2002 of adjusting CPS income reports using administrative data on earnings and benefits from the SSI and Old-Age, Survivors, and Disability Insurance programs. We assessed poverty using both the official standard and a "relative" standard based on half of median pretax, posttransfer income. This article extends that work through 2005. We find that including administrative data presents challenges, but under the methodology we adopt, such adjustments lower estimated official poverty overall and increase estimated poverty rates for elderly SSI recipients. Relative poverty rates are much higher than official poverty rates. By any of the applied standards and procedures for income adjustment, poverty changed little over the 2002-2005 interval.


Am I unlucky because of the terrible things that happened to me as a child, or am I lucky because of the life I lead now? I hardly know myself. All I can tell you is that no sane person would ever choose war over peace. War is inhuman madness. War is what people do to each other when they have completely forgotten the sacredness of life. In 1978, Juliet Lac fled war-ravaged Vietnam in a fishing boat, desperately hoping to find freedom in America. Conditions on the small, overcrowded vessel were horrific, and eight days into the journey, disaster struck. As the craft came in sight of shore, it was hit by a ferocious storm. The boat sank with the loss of half of the 350 passengers on board, but miraculously Juliet escaped, eventually making her way to the USA to begin her new life. Aged only eleven, Juliet had witnessed at first hand the barbarity of war, and after the death of her father and her younger sister, she and her mother were left to struggle on in poverty. But their flight to the West did not have a fairy-tale ending, and in the coming years they faced a struggle to integrate into American society. This is a remarkable and inspirational story of a war child's fight first for survival in the devastated landscape of Vietnam and then for acceptance in the affluent West.


This thesis considers the use of multivariate statistical methods in relation to a common signal processing problem, that of detecting features in sound recordings which contain interference, distortion and background noise.

Two separate but related areas of study are undertaken, first, the compression and noise reduction of sounds; second, the detection of intermittent departures ('signals') from the background sound environment ('noise'), where the latter may be evolving and changing over time.

Compression and noise reduction are two closely related areas that have been studied for a wide range of signals, both one dimensional (such as sound) and two dimensional (such as images). Many well known techniques used in this field are based on the Fourier transform. In this work, we show how the comparative recent wavelet transform is superior for sound data involving short duration signals (such as shrimp clicks) whilst being at least as good as the Fourier transform for longer duration signals (such as dolphin whistles). Various noise reduction techniques involving thresholding wavelet transforms are examined and compared. We show how none of the standard threshold methods cope well with underwater sounds to any reasonable degree and propose a new technique, known as RunsThresh to overcome the perceived problems. The performance of this new method is contrasted with that of various standard thresholds.

Signal identification for underwater sounds is an area that has been examined in detail in much previous work. Here, we build upon the results gleaned from noise reduction to develop a methodology for detecting signals. The underwater noise environment is dynamically modelled using recursive density estimation of certain summary features of its wavelet decomposition. Observations which are considered to be outliers from this distribution are flagged as 'signal'. The performance of our signal detection method is illustrated on artificial data, containing known signals, and on real data. This performance is compared with standard Fourier based methods for both cases.

Finally in this thesis, several ideas are presented and discussed which consider how the noise reduction and signal detection techniques examined in earlier chapters could be developed further, for example, in order to classify detected signals into different classes. These ideas are presented in outline only and are not followed up in detail, since they represent interesting directions for future study, rather than a primary focus of this thesis.


A 31 +2 weeks gestational age, birthweight 1,490 g female was born after an emergency C-section due to abruptio placenta. The Apgar score was 4/8/8, needing positive pressure followed by nasal continuous airway positive pressure (NCPAP). One dose of poractant alfa was administered in the first hour of life. On day 4 (D4) of life, the 2D-echocardiogram performed due to a systolic murmur showed the presence of a hemodynamically significant patent ductus arteriosus. After two cycles of intravenous ibuprofen in standard doses (three doses per cycle: first dose 10 mg/kg/day once a day, followed by two doses of 5 mg/kg/day once a day), the ductus arteriosus (DA) remained significant. The DA was surgically ligated on D12, successfully. On D3 postoperative, she was extubated to NCPAP, maintaining mild respiratory distress. During a progressive increase of enteral feeding, she presented with increased work of breathing and maintenance of oxygen supply, despite a normal chest X-ray. On D25 of life, the chest X-ray revealed an elevation of the left diaphragm. What is your diagnosis? Would you perform any complementary test to confirm the suspected diagnosis? What do you expect to observe on physical examination? What approach and outcome are suggested for this patient?


Neuropathic pain is an important problem because of its complex natural history, unclear etiology, and poor response to standard physical therapy modalities. It causes severe disability unrelated to its etiology. The primary goal of neuropathic pain management is to investigate the underlying cause, to make the differential diagnosis, to eliminate risk factors, and to reduce pain. The physician should also be aware of functional, and psychological conditions of the patient. Therefore, a multimodal management plan in neuropathic pain is essential. In this article, we aimed to reflect a diverse point of view about various physical therapy modalities and rehabilitation techniques. For this purpose, we searched articles about physical therapy modalities and rehabilitation techniques in PubMED database and presented various studies according to their relevance. New rehabilitation techniques seem promising however there is a requirement for more randomized controlled trials with larger patient groups. In this review, we suggest that physical therapy modalities and rehabilitation techniques are very important options and must be considered with pharmacotherapy.


Analysis of live and dynamic movements by computer is one of the areas that draws a great deal of interest to itself. One of the important parts of this area is the motion capture process that can be based on the appearance and facial mode estimation. The aim of this study is to represent 3D facial movements from estimated facial expressions using video image sequences and applying them to computer-generated 3D faces. We propose an algorithm which can classify the given image sequences into one of the motion frames. The contributions of this work lie mainly in two aspects. Firstly, an optical flow algorithm is used for feature extraction, that instead of using two subsequent images (or two subsequent frames in a video), the distinction between images and the normal state is used. Secondly, we realize a multilayer perceptron network that their inputs are matrices obtained from optical flow algorithm to model a mapping between person movements and database movement categories. A three-dimensional avatar, which is made by means of Kinect data, is used to represent the face movements in a graphical environment. In order to evaluate the proposed method, several videos are recorded in order to compare the available modes and discovered modes. The results indicate that the proposed method is effective.


Anyone who proves that he or she is in a situation of danger and who is a potential victim of a violation of a right set forth in the American or the European Convention on Human Rights may be protected by interim measures. Interim measures in the human rights systems may be defined as an instrument, the purpose of which is to prevent irreparable harm to persons who are in a situation of extreme gravity and urgency, which a favourable final judgment would therefore not be able to undo. They result in protection offered by the State in compliance with the legally binding order of the Inter-American or European Court on Human Rights. While this legal figure is nowadays applied more and more frequently and in most cases the American and European countries have complied with the order of their respective Court of Human Rights, the question that this contribution would like to answer is what the legal consequences of incompliance are and whether the difference as to the legal basis of the interim measures in both human rights systems has influenced the legal effect that the respective Courts have given to non-compliance with the measures. After an overview of the case-law, it will be shown that in fact each regional system has given different legal consequences to the incompliance with its interim measures, but paradoxically, the effects are not directly related to the type of legal instrument in which the interim measures are contemplated. The issue is relevant because on the one hand interim measures are mostly adopted in dramatic contexts where the life and personal integrity of human beings are endangered and because a survey of the case-law shows that under the European system the cases of incompliance seem to be on the rise, and on the other hand, because it appears that under the Inter-American system there are many cases in which provisional measures have been issued which will be decided soon on the merits, and therefore during the examination of which it will be decided whether the member States have complied or not with the Inter-American Court's interim measures and what consequences incompliance entails.


Stereotactic body radiation therapy (SBRT) offers excellent local control of early-stage non-small cell lung cancer (NSCLC), but there currently is a need for tolerable systemic therapy to address regional and distant disease progression. One potential option is immunotherapy, which in metastatic NSCLC has shown promise for sustained disease control in a subset of patients. There is also growing evidence for a clinical synergy between radiation and immunotherapy, with several ongoing trials studying the abscopal effect. This review summarizes the current data in the fast-changing field of immuno-radiation therapy, highlighting updates from recent clinical trials.


The oil sands mining and extraction processes in Canada produce large volumes of tailings that are a mixture of mainly water, clay, sand, chemicals and bitumen. This mixture is transported to tailings ponds, where gravity segregation occurs. During this process, a stable suspension called mature fine tailings (MFT) is formed, which requires many years to fully consolidate. Therefore, land reclamation and water recirculation become significant environmental issues. For this reason, it is important to understand the tailings' content and their settling properties. This study uses the low-field nuclear magnetic resonance (NMR) technique to estimate the water, bitumen and solids composition of synthetic and real tailings samples through a bimodal compositional detection method under ambient conditions. NMR measurements were conducted in 15 minutes, which is a relatively fast measurement allowing for rapid monitoring of tailings compositions. The results show that the NMR technique can be a potential on-site fast measurement of composition and settling characteristics of tailings.


This article proposes that courts substitute immediate substantive review for procedural review of agency guidance documents. The article begins by reviewing the extensive literature about how courts should treat non-legislative rules. Because such rules play an important role in assuring coherence and accountability of agency policies and interpretations and in communicating the views of agencies about such matters the article agrees with those who advocate ex-post monitoring of agency use of rules issued without notice and comment procedures. Recognizing that ex-post monitoring leaves much leeway for agencies to abuse guidance documents by depriving stakeholders of opportunities to participate in their development and of obtaining substantive judicial review of them, the article advocates that non-legislative rules generally should be subject to arbitrary and capricious review when issued. The article proceeds to explain why other proposals to rein in agency discretion to use guidance documents – in particular making the agency explain its decision to proceed by this mode and forcing the agency to consider timely petitions for reconsideration of such documents – are likely to have less effect with greater cost than its proposal for direct review of guidance documents. In advocating for such review, however, the article contends that courts will need to massage doctrines governing availability of review, such as those governing finality and ripeness of guidance documents. Even more significantly, the article argues that review for reasoned decision-making will have to be modified to avoid seriously compromising the speed and procedural flexibility which makes guidance documents an attractive means for agencies to communicate their views of policy and interpretation. It therefore develops a variant on arbitrary and capricious review that would require agencies to explain issuance of guidance in terms of factors that are relevant and alternatives that are plausible given the state of knowledge available to the agency when it acted. The article concludes that such a doctrine can encourage agencies to solicit input even from stakeholders outside the issue networks affected by the guidance document, while preserving sufficient flexibility for the agency to issue the document quickly and without undue procedural burden.


The economic crisis has shifted the emphasis in the debate about macroeconomic imbalances. Where once the attention focused on deficit countries, and the United States in particular, now it centers more on surplus countries like China. The argument is that these surplus countries have fostered the crisis through their single-minded determination to pursue export-led growth. They have also distorted their domestic economies along the way. Moreover, the deficit countries cannot resolve their imbalances acting alone. The time has come to reconsider the wisdom of export-led growth strategies both in the developing world and elsewhere. If accepted, these arguments will have important implications for how the world economy is reformed.


Some of the most challenging questions in philosophical ethics concern the justification of action. Can you have reasons to do something that you are not, and perhaps cannot be, motivated to do? If reasons rest on desires, why respect the rights and interests of others when doing so prevents us from getting what we want? In other words, why be moral? In his 1979 essay, "Internal and External Reasons," Bernard Williams framed the dispute about reason and motivation in a way that captured the philosophical imagination. An explosion of work on reasons and action followed, with influential responses by Christine Korsgaard, John McDowell, and Michael Smith. This volume collects the most important work on the topic, including Williams's seminal essay, the responses by Korsgaard, McDowell, and Smith, and more recent contributions by central figures. Taken together, the selections offer a comprehensive survey of state-of-the-art work on internal reasons and a distinctive, focused approach to foundational questions of ethical objectivity. A substantive introduction by Kieran Setiya skillfully guides the reader through the theoretical and conceptual terrain, explaining what is at stake in the larger debate.


Latitudinal clinal variation in wing size and shape has evolved in North American populations of Drosophila subobscura within about 20 years since colonization. While the size cline is consistent to that found in original European populations (and globally in other Drosophila species), different parts of the wing have evolved on the two continents. This clearly suggests that 'chance and necessity' are simultaneously playing their roles in the process of adaptation. We report here rapid and consistent thermal evolution of wing shape (but not size) that apparently is at odds with that suggestion. Three replicated populations of D. subobscura derived from an outbred stock at Puerto Montt (Chile) were kept at each of three temperatures (13, 18 and 22 °C) for 1 year and have diverged for 27 generations at most. We used the methods of geometric morphometrics to study wing shape variation in both females and males from the thermal stocks, and rates of genetic divergence for wing shape were found to be as fast or even faster than those previously estimated for wing size on a continental scale. These shape changes did not follow a neat linear trend with temperature, and are associated with localized shifts of particular landmarks with some differences between sexes. Wing shape variables were found to differ in response to male genetic constitution for polymorphic chromosomal inversions, which strongly suggests that changes in gene arrangement frequencies as a response to temperature underlie the correlated changes in wing shape because of gene‐inversion linkage disequilibria. In fact, we also suggest that the shape cline in North America likely predated the size cline and is consistent with the quite different evolutionary rates between inversion and size clines. These findings cast strong doubts on the supposed 'unpredictability' of the geographical cline for wing traits in D. subobscura North American colonizing populations.


We tackle the problem of visual search under resource constraints. Existing systems use the same embedding model to compute representations (embeddings) for the query and gallery images. Such systems inherently face a hard accuracy-efficiency trade-off: the embedding model needs to be large enough to ensure high accuracy, yet small enough to enable query-embedding computation on resource-constrained platforms. This trade-off could be mitigated if gallery embeddings are generated from a large model and query embeddings are extracted using a compact model. The key to building such a system is to ensure representation compatibility between the query and gallery models. In this paper, we address two forms of compatibility: One enforced by modifying the parameters of each model that computes the embeddings. The other by modifying the architectures that compute the embeddings, leading to compatibility-aware neural architecture search (Cmp-NAS). We test Cmp-NAS on challenging retrieval tasks for fashion images (DeepFashion2), and face images (IJB-C). Compared to ordinary (homogeneous) visual search using the largest embedding model (paragon), Cmp-NAS achieves 80-fold and 23-fold cost reduction while maintaining accuracy within 0.3% and 1.6% of the paragon on DeepFashion2 and IJB-C respectively.


Network virtualization is seen by many as a key technology to help overcome some of the constraints of the current Internet architecture and help build a "human centric" Future Internet. As IPTV gains popularity, creating virtual networks for IPTV Service Providers can allow them to deploy specific protocol suites, routing algorithms and resource allocation strategies without affecting other IPTV providers that share the same underlying infrastructure. However, from the perspective of the underlying networking infrastructure provider (the "carrier") virtualization presents new management challenges, in particular how to efficiently and fairly allocate available resources to multiple virtual networks. In this paper we describe a framework in which management systems associated with virtual IPTV provider networks communicate with the management system of the carrier to provide coordinated resource allocation. The proposed approach allows policy-based management systems to control a bio-inspired resource management mechanism, based on species competition for biological systems, that a carrier can use to allocate resources to competing IPTV providers in a manner that maximizes the carrier's revenue. Results of a simulation study are presented, which show that this approach outperforms uncoordinated virtual network management approaches.


Regeneration of a hybrid zone between E. amygdalina and E. risdonii and pure species stands following wildfire is reported, as well as the reproductive and vegetative fitness of parental and hybrid phenotypes. E. risdonii phenotypes dominated the seed rain and seedling cohort and there was clearly a marked fitness differential between E. amygdalina and E. risdonii at their boundary. When the F1 type hybrid is in competition with both parental types it is generally reproductively the least fit, although frequently vegetatively vigorous. Reduced fitness appears to extend to advanced generations as hybrid phenotypes tending.toward either species are, on average, less fit than the corresponding parental type. The pattern of phenotypic fitness suggests that the species' boundary is in disequilibrium and it is argued that E. risdonii is invading the range of E. amygdalina by both pollen and seed migration. There is an asymmetric distribution of F1 type hybrids across the boundary and the hybrid swarm examined is being invaded by E. risdonii genes. It is suggested that hybridization may be associated with natural disequilibrium and, where seed migration is limited, boundary movements may be preceded by a wave of hybridization due partly to pollen swamping of the least fit species. Hybrid swarms may develop but, at the boundary of large stands, are probably transitory. There is a marked inertia in the population response to the prevailing selective regime due to the extremely slow population turnover and limited dispersal potential. This is discussed in the broader context of non-equilibrium models where it is argued that dispersal may be the factor limiting population response to perturbation of a shallow environmental gradient. This is due to large geographical shifts in the position of the null point and would be accentuated in a patchy environment where migration as a front is prevented.


The proton affinities (PA) of all isomeric dimethylacetophenones were determined using the 'kinetic method' with a tandem mass spectrometer and by measurements of the proton transfer equilibrium in the gas phase by Fourier transform ion cyclotron resonance mass spectrometry. For both methods acetophenone and p-methylacetophenone, with well known PA values, were used as reference bases. Both methods yielded identical PA values for all dimethylacetophenones. The PA of the dimethylacetophenones were in a narrow range between 872 and 880 kJ mol-' except for 2,6-dimethylacetophenone, for which a PA of 856 kJ mol-' was found. The results are discussed in terms of possible mesomeric structures stabilizing the positive charge with regard to the substitution pattern in the phenyl ring. Obviously, the significant smaller PA of 2,&dimethylacetophenone compared with the other isomers is due to the distortion of the conjugation of the C-0 double bond with the aromatic n system.


We introduce a new type of Fano resonances, realized in a photonic circuit which consists of two nonlinear PT-symmetric micro-resonators side-coupled to a waveguide, which have line-shape and resonance position that depends on the direction of the incident light. We utilize these features in order to induce asymmetric transport up to 47 dBs in the optical C-window. Our set-up requires low input power and does not compromise the power and frequency characteristics of the output signal.


The better the software development community becomes at creating software, the more software the world seems to demand. Although there is a large body of research about measuring and investigating productivity from an organizational point of view, there is a paucity of research about how software developers, those at the front-line of software construction, think about, assess and try to improve their productivity. To investigate software developers' perceptions of software development productivity, we conducted two studies: a survey with 379 professional software developers to help elicit themes and an observational study with 11 professional software developers to investigate emergent themes in more detail. In both studies, we found that developers perceive their days as productive when they complete many or big tasks without significant interruptions or context switches. Yet, the observational data we collected shows our participants performed significant task and activity switching while still feeling productive. We analyze such apparent contradictions in our findings and use the analysis to propose ways to better support software developers in a retrospection and improvement of their productivity through the development of new tools and the sharing of best practices.


This biography of the seventh director of the National Park Service brings to life one of the most colorful, powerful, and politically astute people to hold this position. George B. Hartzog Jr. served during an exciting and volatile era in American history. Appointed in 1964 by Secretary of the Interior Stewart Udall, he benefited from a rare combination of circumstances that favored his vision, which was congenial with both President Lyndon Johnson's "Great Society" and Udall's robust environmentalism.Hartzog led the largest expansion of the National Park System in history and developed social programs that gave the Service new complexion. During his nine-year tenure, the system grew by seventy-two units totaling 2.7 million acres including not just national parks, but historical and archaeological monuments and sites, recreation areas, seashores, riverways, memorials, and cultural units celebrating minority experiences in America. In addition, Hartzog sought to make national parks relevant and responsive to the nation's changing needs.


OBJECTIVES
To quantify rates of stand-alone e-prescribing (SEP) adoption and use among primary care physicians (PCPs) participating in a SEP initiative and to determine which physician and patient characteristics were associated with higher rates of each.

STUDY DESIGN
Using records from an insurer-led SEP initiative, we compared the characteristics of 297 PCPs who adopted SEP through the initiative with the characteristics of 1892 eligible PCPs who did not. Among 297 adopters, we studied the extent of SEP use.

METHODS
Dependent variables included each physician's adoption of SEP and his or her e-prescribing use ratio (the ratio of electronic prescriptions to pharmacy claims in the same period). Independent variables included characteristics of PCPs (specialty, practice size, and prescribing volume) and their patients (patient age, sex, race/ethnicity, and household income).

RESULTS
Solo practitioners, pediatricians, and physicians with more patients from predominantly African American zip codes were underrepresented among SEP adopters. The mean (SD) e-prescribing use ratio among adopters was 0.23 (0.28). Twenty percent of physicians maintained e-prescribing use ratios above 0.50. Available physician characteristics explained little of the variance in use, but physicians in smaller practices had greater use (P = .02).

CONCLUSIONS
Certain categories of physicians may need more tailored incentives to adopt SEP. On average, adopters used the SEP system for only about one-quarter of their prescriptions. Some adopters achieved high levels of SEP use, and further research is needed to elucidate the factors that enabled this.


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It is well established that transcription factors (TFs) play crucial roles in determining cell identity, and that a large fraction of all TFs are expressed in most cell types. In order to globally characterize activities of TFs in cells, we have developed a novel massively parallel protein activity assay, Active TF Identification (ATI) that measures DNA-binding activity of all TFs from any species or tissue type. In contrast to previous studies based on mRNA expression or protein abundance, we found that a set of TFs binding to only around ten distinct motifs display strong DNA-binding activity in any given cell or tissue type. Mass spectrometric identification of TFs revealed that within these highly active TFs, there were both housekeeping TFs, which were universally found in all cell types, and specific TFs, which were highly enriched in known factors that determine the fate of the analyzed tissue or cell type. The importance of a small subset of TFs for determining the overall accessible chromatin landscape of a cell suggests that gene regulatory logic may be simpler than what has previously been appreciated.


Hoffman v. Red Owl Stores is one of the storied cases in modern contract law. The conventional wisdom is that Hoffman represents the emergence of a new legal rule imposing promissory estoppel liability for representations made during preliminary negotiations. Yet a review of contemporary case law shows that, in fact, courts require some form of agreement before they will grant recovery for early reliance. Hoffman's main legacy, therefore, has been as a trap for the unwary lawyer (and unhappy client) who unsuccessfully seek recovery for reliance on preliminary negotiations. This article asks how the court in Hoffman was able to find liability where other courts have not. A careful examination of the trial record shows that the conventional understanding of the facts in Hoffman is simply wrong. The true facts show that the breakdown in the negotiations between Hoffman and Red Owl officials was a product of a misunderstanding as to the nature of his financial contribution to the enterprise, a misunderstanding as attributable to Hoffman's carelessness as to any representations made by Red Owl's agents. The article then uses a large sample of decided cases to recover the law in action that governs precontractual liability. This sample highlights the emergence of a new default rule that imposes liability for a failure to bargain in good faith following a binding preliminary commitment. This new legal duty has been largely unexplored in the casebooks or the secondary literature, in part because of the misplaced attention paid to the unfortunate controversy between Mr. Hoffman and Red Owl Stores.


Objective: To examine the prevalence of auditory neuropathy in a group of infants at risk for hearing impairment and to present an overview of the clin ical findings for affected children. Design: Results for 20 subjects who showed repeat able cochlear microphonic potentials in the absence of click-evoked auditory brain stem responses are included in this study. Behavioral and steady state evoked potential thresholds were established in each case. Where possible, otoacoustic emission and speech perception results (unaided and aided) also were obtained. Results: One in 433 (0.23"/() of the children in our series had evidence of auditory neuropathy. The audiometric findings for these subjects varied sig nificantly, with behavioral thresholds ranging from normal to profound levels. Discrimination skills were also variable. Approximately half of the sub jects showed little understanding, or even aware ness, ofspeech inputs in both the unaided and aided conditions. There were, however, a number of chil dren who could score at significant levels on speech discrimination tasks and who benefited from the provision of amplification. Conclusion: The results suggest that auditory neu ropathy is more common in the infant population than previously suspected. The effects of neuropa thy on auditory function appear to be idiosyncratic, producing significant variations in both the detec tion and discrimination of auditory signals. As such, the management of children with this disorder must allow for individual differences.


A small portable spectrometer was developed to monitor oxygen and hydrogen as the free or dissociation products in the tungsten arc–inert gas welding process. The hydrogen (6562.8 Å) and oxygen (7771.9 Å) lines were monitored and the argon (8521.4 Å) line was used for the internal standard. The instrument, a fixed Eagle mount, used a 76×50 mm, 60 cm focal length, concave grating with 610 grooves/mm blazed in the second order. The reciprocal dispersion at 6562 Å was 12 Å/mm. The oxygen triplet was resolved. Optical design requirements included the use of very short arc lengths in the order of 0.5 mm and less, an optical plane of 65° to 75deg; with a large flat plate instead of the conventional 90° with respect to the electrodes, and an arc that does not remain in a fixed optical position in space. The focusing lens-limiting aperture assembly was mounted on the torch head with a fiber optic bundle transmitting the light to the spectrometer. The instrument recorded only the signal above background, including the very high background produced by introducing the electrode tip into the optical path. This was accomplished by the use of an oscillating optical block in the entrance beam which yields an ac signal above the dc signal from background. The direct ratio readout system used a Devar ratio computer in each analytical channel and was essentially instantaneous.


Self-cleaning coatings, with benefits to environment, energy and labor saving, have attracted great attention due to their potential application in many aspects of human's daily life. In this perspective article, the recent efforts to understand and improve photo-induced hydrophilicity and self-cleaning properties of TiO2 are reviewed. Particular attention is paid to the fundamental aspects and mechanism of the photo-induced hydrophilicity effect. The challenges that need to be addressed over the coming years to improve the efficiency and extend the application are also presented.


Stress granules (SGs) are membrane-less dynamic structures consisting of mRNA and protein aggregates that form rapidly in response to a wide range of environmental cellular stresses and viral infections. They act as storage sites for translationally silenced mRNAs under stress conditions. During viral infection, SG formation results in the modulation of innate antiviral immune responses, and several viruses have the ability to either promote or prevent SG assembly. Here, we show that rabies virus (RABV) induces SG formation in infected cells, as revealed by the detection of SG-marker proteins Ras GTPase-activating protein-binding protein 1 (G3BP1), T-cell intracellular antigen 1 (TIA-1) and poly(A)-binding protein (PABP) in the RNA granules formed during viral infection. As shown by live cell imaging, RABV-induced SGs are highly dynamic structures that increase in number, grow in size by fusion events, and undergo assembly/disassembly cycles. Some SGs localize in close proximity to cytoplasmic viral factories, known as Negri bodies (NBs). Three dimensional reconstructions reveal that both structures remain distinct even when they are in close contact. In addition, viral mRNAs synthesized in NBs accumulate in the SGs during viral infection, revealing material exchange between both compartments. Although RABV-induced SG formation is not affected in MEFs lacking TIA-1, TIA-1 depletion promotes viral translation which results in an increase of viral replication indicating that TIA-1 has an antiviral effect. Inhibition of PKR expression significantly prevents RABV-SG formation and favors viral replication by increasing viral translation. This is correlated with a drastic inhibition of IFN-B gene expression indicating that SGs likely mediate an antiviral response which is however not sufficient to fully counteract RABV infection.


This paper, which partially draws on the author's Tommaso Padoa-Schioppa inaugural lecture at the EUI, is an updated and augmented version of a contribution to the Hertie School's Governance Report 2018, published under the title 'Is global governance passe?'. The high point of global governance was reached in the mid-1990s around the creation of the World Trade Organisation. It was hoped that globalisation would be buttressed by a system of global rules and a network of specialised global institutions. Two decades later these hopes have been dashed by a series of global governance setbacks, the rise of economic nationalism and the dramatic change of attitude of the United States administration. From trade to the environment, a retreat from multilateralism is observable. The 2008 elevation of the G20 to leaders' level was an exception to this trend. But the G20 is no more than a political steering body. The reasons for this retreat partially arise from political developments in individual countries. But such factors hide a series specific roadblocks to global governance - the growing number and diversity of countries involved; the mounting rivalry between the US and China; doubts about globalisation and the distribution of the associated benefits; the obsolescence of global rules and institutions; imbalances within the global governance regime; and increased complexity. What, then, should be the way forward? The demand for global governance has not diminished, but support for binding multilateral arrangements has. There is a need for alternative governance technologies that better accommodate the diversity of players, provide for more flexibility and rely less on compulsion. From competition to financial regulation, such arrangements have been developed in a series of fields already. They are often hailed as providing a solution to the governance conundrum. But their effectiveness should be assessed critically. Can they overcome the free-rider curse and enforcement problems? Usual game theory suggests not. Not all games are similar, however, and some collective action problems can be tackled without recourse to coercion. Against this background, multilateralists hesitate over the choice of a strategy. One option would be to seek to preserve the existing order to the greatest extent possible. Its downside is that it does not address the underlying problems. An alternative option is to try to redesign international arrangements, putting the emphasis on flexibility and voluntary participation. Its downside is that it risks overlooking the intrinsic problems of international or global collective action. A potentially more promising approach would be to define the minimum conditions that the multilateral framework must fulfil to provide a strong-enough basis for flexible, variable-geometry and possibly informal arrangements. In the end, we should neither cultivate the nostalgia of yesterday's order nor invest our hopes in ineffective international cooperation. The narrow path ahead is to establish a sufficient, critical multilateral base for flexible arrangements and to equip policymakers with a precise toolkit for determining, on a field-by-field basis, the minimum requirements for effective collective action.


Enterprise Resource Planning (ERP) systems have recently gained significance among companies, organizations, higher education institutions, and business owners in Oman. Delving into the implementation and success of ERP systems is a time-consuming process and mostly requires longitudinal research. In line with the significance of such systems, we conducted a qualitative study to understand the practices involved in developing ERP systems from the perspectives of the software project managers and developers. In doing so, we interviewed a software project management and development team. The interview included both structured and semi-structured questions. We focused on three factors, including a) the software project managers' and developers' viewpoints about the ERP systems development in the HEIs, b) the methods and processes followed by the team while developing ERP systems for the HEIs, and c) the technical and non-technical challenges encountered within the development, implementation, and deployment stages.


ABSTRACT Key points identified in this study to break through the glass ceiling and reach not only gender parity, but also a work–life balance from which all employees can equally benefit, are: improve girls' position early on at school, give women sponsors and mentors to help them develop the competencies to be confident, offer parental leave to encourage women to come back after giving birth, implement new work forms, give employees the possibility for care work, and put legal and political regulations as well as policies in place to influence companies' decisions when implementing new measures. To introduce new measures into a company's organizational structure, a detailed research process on which measures are requested and can be implemented, as well as an external consultant or tool, need to be used. This process is very individual per company. The goal is to improve employee satisfaction, have less fluctuations, and put extra financial costs into perspective.


International arbitration arose as a global phenomenon with the growth of transcontinental trade in a progressive smaller world. As its role and importance have become defined, the use of arbitration as an alternative dispute resolution has increased all around the world accordingly. However, even with unified international documents, such as the 1958 New York Convention1, 1965 Washington Convention2, 1985-2006 United Nations Commission on International Trade Law, or UNICITRAL Model Law3, arbitration has been approached differently domestically, thus facing conflicts or controversies. This paper has as main objective to explain the key points concerning arbitration within the Brazilian legal system. The evolution of arbitration will be studied since the Iberian Union in the colonial era4 in order to bring about the formation of its legal characteristics. Besides, the current Brazilian Arbitration Act, promulgated in 1996, will be analyzed focusing on its provision gaps. The Sulamerica-Enesa arbitral award will be the case study of this paper, which will contribute to a better understanding of the increase in conflicts with the use of this method of dispute resolution. Last, an overview of the Brazilian arbitration legislation as well as its "gaps" will determine that in spite of arbitration being successfully implemented in Brazil, there is still an eminent need to improve legislation, which will be substantial to avoid further conflicts in lex arbitri, lex curia and lex contractus within arbitration itself.


This analysis uses the 2011 FAPRI-CARD (Food and Agricultural Policy Research Institute–Center for Agricultural and Rural Development) baseline to evaluate the impact of four alternative scenarios on U.S. and world agricultural markets, as well as on world fertilizer use and world agricultural greenhouse gas emissions. A key assumption in the 2011 baseline is that ethanol support policies disappear in 2012. The baseline also assumes that existing biofuel mandates remain in place and are binding. Two of the scenarios are adverse supply shocks, the first being a 10% increase in the price of nitrogen fertilizer in the United States, and the second, a reversion of cropland into forestland. The third scenario examines how lower energy prices would impact world agriculture. The fourth scenario reintroduces biofuel tax credits and duties. Given that the baseline excludes these policies, the fourth scenario is an attempt to understand the impact of these policies under the market conditions that prevail in early 2011. A key to understanding the results of this fourth scenario is that in the absence of tax credits and duties, the mandate drives biofuel use. Therefore, when the tax credits and duties are reintroduced, the impacts are relatively small. In general, the results show that the entire international commodity market system is remarkably robust with respect to policy changes in one country or in one sector. The policy implication is that domestic policy changes implemented by a large agricultural producer like the United States can have fairly significant impacts on the aggregate world commodity markets. A second point that emerges from the results is that the law of unintended consequences is at work in world agriculture. For example, a U.S. nitrogen tax that might presumably be motivated for environmental benefit results in an increase in world greenhouse gas emissions. A similar situation occurs in the afforestation scenario in which crop production shifts from high-yielding land in the United States to low-yielding land and probably native vegetation in the rest of the world, resulting in an unintended increase in global greenhouse gas emissions.


Menopausal hormone therapy (MHT) is characterized by use of different constituents, regimens and routes of administration. We investigated the association between the use of different types of MHT and breast cancer risk in the EPIC cohort study. The analysis is based on data from 133,744 postmenopausal women. Approximately 133,744 postmenopausal women contributed to this analysis. Information on MHT was derived from country‐specific self‐administered questionnaires with a single baseline assessment. Incident breast cancers were identified through population cancer registries or by active follow‐up (mean: 8.6 yr). Overall relative risks (RR) and 95% confidence interval (CI) were derived from country‐specific Cox proportional hazard models estimates. A total of 4312 primary breast cancers were diagnosed during 1,153,747 person‐years of follow‐up. Compared with MHT never users, breast cancer risk was higher among current users of estrogen only (RR: 1.42, 95% CI 1.23–1.64) and higher still among current users of combined MHT (RR: 1.77, 95% CI 1.40–2.24; p = 0.02 for combined vs. estrogen‐only). Continuous combined regimens conferred a 43% (95% CI: 19–72%) greater risk compared with sequential regimens. There was no significant difference between progesterone and testosterone derivatives in sequential regimens. There was no significant variation in risk linked to the estrogenic component of MHT, neither for oral vs. cutaneous administration nor for estradiol compounds vs. conjugated equine estrogens. Estrogen‐only and combined MHT uses were associated with increased breast cancer risk. Continuous combined preparations were associated with the highest risk. Further studies are needed to disentangle the effects of the regimen and the progestin component.


Although mature technologies at competitive prices are largely available, solar thermal is not yet playing the important role it deserves in the reduction of buildings fossil energy consumption. The generally low architectural quality characterizing existing building integrations of solar thermal systems pinpoints the lack of design as one major reason for the low spread of the technology. As confirmed by the example of photovoltaics, the improvement of the architectural quality of building integrated systems can increase the use of a solar technology even more than price and technique. This thesis investigates the possible ways to enhance the architectural quality of building integrated solar thermal systems, and focuses on integration into facade, where the formal constraints are major and have most impact. The architectural integration problematic is structured into functional, constructive and formal issues, so that integration criteria are given for each architectural category. As the functional and constructive criteria are already recognized by the scientific community, the thesis concentrates on the definition of the formal ones, yet underestimated or misunderstood. The results of a large European survey over architects and engineers perception of building integration quality are presented, showing that for architects formal issues are not a matter of personal taste, but that they relate to professional competences, and consequently can be described. The solar system characteristics having an impact on the formal quality of the integration are identified (formal characteristics), the related integration criteria are assessed, and finally integration guidelines to support architect integration design work are given. The limits imposed by the collectors available in the market are pointed out, showing that the lack of appropriate products is nowadays the main barrier to BIST (Building Integrated Solar Thermal) architectural quality. A methodology for the development of new solar thermal collectors systems responding at the same time to energy production needs and building integration requirements is defined. The importance to ensure, within the design team, the due professional competences in both these fields is stressed. Three progressive levels of system "integrability" are defined in the path leading to the concept of "active envelope systems" and the main role of facade manufacturers is highlighted. The methodology is applied to unglazed and glazed flat plate systems, and new facade system designs are proposed that show the relevance of the proposed approach.


This short paper, delivered at the American Society of International Law's 107th Annual Meeting in 2013, summarizes for the international lawyer the recent legal repositioning of economic and social rights. Three trends – of the new wave of constitutionalism, new models of adjudication, and innovations from the Global South – are described, as precursors to the entry into force of the Optional Protocol to the International Covenant on Economic, Social and Cultural Rights. The conceptual map concludes with the difficult prognosis of measuring the success of experiments in economic and social rights advocacy and reform.


Evidence is mounting from a number of studies undertaken with groups of learners of all ages and all abilities that there is a particular factor common to successful language learners: strategic competence involving the use of appropriate learning strategies. The growing body of research into this area has not, however, had much to say so far about the special situation of those learning a language at a distance. Based on the findings of surveys and discussions carried out with students enrolled in the final year of the Diploma in French at the Open University, this paper investigates learner beliefs about learning a language at a distance, difficulties encountered, attitudes to learner support and the use of strategies. It concludes that metacognitive strategies may have an enhanced role for the learner of a language at a distance, but that further research is needed to determine more clearly the nature of this role, how metacognitive strategies relate to learner variables and the specific implications for learner autonomy, tutor support and course design.


The effects of neem formulations applied as soil drenching on the development of second stage juveniles (J2) of Meloidogyne javanica on roots of susceptible tomato cv. Tiny-Tim was investigated at controlled environment consisted of photoperiod of 16 h light/8 h dark at 30 o C during light and 24.1 o C during dark. Thirty day old seedlings were transplanted singly in 15cm diam., pots filled with autoclaved proprietary based loam. Beginning 7-days after transplant, three neem formations viz., neem cake, aza 5 mg and 10 mg were drenched @ 10 ml per pot. Water and 4% ethanol treated plants were included as check for comparison. Three days after the application, plants were inoculated with freshly hatched 250 J2 suspended in 10 ml of water surrounding root zone of each plant. Each treatment consisted of 5 replications. The experimental plants were completely randomized on a bench in a growth room. The roots of tomato plants drenched with three neem formulations and ethanol equal numbers of J2 penetrated but significantly less than that of water check plants. Three neem treatments including aza (5mg), aza (10mg) arrested the development of J2 over that of water check. The roots of plants treated with aza (10mg) allowed less number of J2 to develop into immature females than on roots of ethanol check plants. The plants treated with all three neem formulations and ethanol responded less in terms of root gall formation over that of water check. Aza at 10mg was found most effective in protecting the roots against nematode infection. These findings warrant the use of neem as biocide to manage the nematode populations.