Entrustable professional activities (EPAs) are critical activities performed by medical professionals which can be observed and assessed. Adding on to common EPAs for all pediatric subspecialty trainees, specialty specific EPAs for pediatric gastroenterology, hepatology and nutritional fellowship were developed by the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) EPA Task Force.Having developed specialty specific EPAs, building EPA assessments is the next logical step, as EPAs are included under a larger umbrella of competency-based assessment. Thus, the NASPGHAN EPA Task Force and Training Committee collaborated on an assessment tool and associated curricular resources to aid in tracking trainees' progression to entrustment within individual EPAs and readiness for independent practice.This manuscript reports the development of an EPA assessment tool, including guiding principles and the theory behind the assessment tool, with a focus on simple, meaningful assessments that can provide crucial performance feedback to trainees. In addition, curricular resources were developed, based on the assessment tool, to support training. Ultimately, it is the hope of the NASPGHAN EPA Task Force and Training Committee that this tool can aid training programs in providing formative feedback for trainees, and can be used by training programs and clinical competency committees for summative evaluation.


In a recent report we demonstrated efficient collection of emission by coupling to surface plasmons on a thin silver film, resulting in a directional signal in the glass substrate. We call the phenomenon surface plasmon coupled emission (SPCE). In the present report we examined sulforhodamine 101 (S101) in thin polymer films on 50 nm thick gold films on glass. We observed efficient SPCE through thin gold films. This result was surprising because metallic gold is typically an efficient quencher of fluorescence. The energy effectively coupled through the gold film into the glass at a sharply defined angle, but somewhat less sharp than for a comparable silver film. About 50% of the total emission appeared as SPCE, irrespective of direct excitation or excitation via the plasmon resonance evanescent wave. The emission was p-polarized with different wavelengths appearing at different angles. The lifetime of S101 was mostly unaffected by the gold film. These results indicate that SPCE occurs over long distances, larger than for quenching by energy transfer to the gold. We conclude highly efficient detection devices can be constructed by using fluorophores on gold-coated surfaces.


We study bifurcations in dynamical systems with bounded random perturbations. Such systems, which arise quite naturally, have been nearly ignored in the literature, despite a rich body of work on systems with unbounded, usually normally distributed, noise. In systems with bounded random perturbations, new kinds of bifurcations that we call 'hard' may happen and in fact do occur in many situations when the unperturbed deterministic systems experience elementary, codimension-one bifurcations such as saddle-node and homoclinic bifurcations. A hard bifurcation is defined as discontinuous change in the density function or support of a stationary measure of the system.


Field experiments were carried out to quantify the effects of cover cropping on soil physical properties. Field capacity (FC), permanent wilting point (PWP), soil-water holding capacity (SWHC), bulk density (ρb), saturated and unsaturated hydraulic conductivity (Ks and Kus, respectively), and infiltration rates were measured and compared for four land cover treatments [cover crop without seed maize (CC), seed maize followed by cover crop (SCCC), bare soil, and seed maize without cover crop (SC)] in three large-scale production fields (~64 ha each) with silt loam soil in the 2012-2013, 2013-2014, 2014-2015, and 2015-2016 cover crop growing seasons. All production fields had been in a maize or soybean and cover crop rotation since 2002 and were farmed with row crops for decades before 2002. Field-measured soil properties in the SCCC treatment were also compared with historical values measured by the USDA-NRCS in 1974. In general, soil physical properties were unaffected by incorporating rotational cover crops into row crop cultivation. No significant differences (p > 0.05) in SWHC were observed between the treatments at any of the periods (seasons). When compared to the 1974 NRCS-measured values for the research fields, overall, the FC, PWP, and as a result the SWHC did not exhibit change at the end of the research in 2016 after cultivating cover crops since 2002. Ks values at the topsoil exhibited interannual variation for the same treatments, but there were no significant differences (p > 0.05) in Ks between land cover treatments neither in any year nor for the same treatment between years. Kus values were not significantly different (p > 0.05) between treatments neither for a given year nor between years. On average, the infiltration rate in the SCCC treatment was about 64% lower than in the SC treatment, indicating that incorporating cover crops into a maize-soybean rotation decreased the infiltration rate. While cover crops could be beneficial for grazing due to their nutritional value, and perhaps other benefits, which depend on numerous factors, in this research there was no sufficient evidence that cover crops can significantly alter the soil physical properties that were investigated in these experimental conditions.


The homogeneous immunosensor design described here utilizes the bivalent nature of the antibody. Antigen peptide is conjugated using flexible linkers with short complementary oligonucleotides (signaling oligonucleotides), each of which containing a fluorochrome that can form a fluorescence resonance energy transfer (FRET) donor-acceptor pair. The complementary signaling oligonucleotides are short enough to prevent their annealing on their own. Binding of the peptide-signaling oligonucleotide constructs to bivalent antibody results in a large increase in local concentration of signaling oligonucleotides causing their annealing and appearance of FRET signal. We used simple model system (antibiotin antibody) to obtain proof-of-principle validation of the sensor design. We then constructed two sensors based on two peptides corresponding to the antigens of two antibodies raised against human cardiac troponin I. We demonstrated that these sensors could be used for sensitive detection of the antibody and for competition-based detection of the intact troponin I. Furthermore, we showed that these sensors could be used for detection of kinase activity targeting the antigen peptide. These simple and robust immunosensors may find applications in antibody detection (for example, in diagnosis of autoimmune or infectious disease), in protein detection (especially when speed of detection is essential), and in assays for detecting enzymatic activities involved in post-translational modifications of proteins.


Author(s): Whittaker, Robert J.; Fernandez-Palacios, Jose M.; Matthews, Thomas J.; Rigal, Francois; Triantis, Kostas A. | Abstract: The term meta-archipelago has been in use in cultural studies for some time, to refer to certain complex island areas in which the boundaries between conventionally recognised archipelagos are indistinct, although the concept also carries additional connotations. Use of the term in biogeography appears more recent and without effort to prescribe its meaning. We outline, from a biogeographical perspective, distinctions between meta-archipelagos and archipelagos and those islands not occurring within either collective grouping, highlighting that network analysis tools provide metrics for formal analytical purposes.


To determine the areas of data deficiencies, the totals of sea and swell observations were summarized by unit Marsden squares for the world. An interesting result of this summary was a comparison of the totals of sea and swell observations. The totals of swell observations averaged two-thirds those of sea observations. Although this ratio was fairly representative of the ocean basins, considerable variation occurred in semi-enclosed seas where swell observations averaged only one-tenth those of sea observations. A few ocean basin locations had totals of swell observations that approached those of sea observations, but no Marsden square had more swell observations than sea observations. Strangely enough, swell tabulations, in areas where the ratio of swell to sea observations were smallest (semi-enclosed basins), appeared least reliable although it was suspected at the time that this was probably due to smallness of the sample. Subsequent additions of card decks have neither changed these ratios appreciably nor the suspect reliability. Thus, due to the relative sparseness of observations in some areas and the inexplainable ratios of swell to sea observations in others, the quality of observations contained in IBM listings have for some time been questioned.


This chapter offers an in-depth exploration into one of Adam Kendon's core theoretical assumptions: gesture as "deliberate expressive movement." Gestures are recognized as such because they show certain characteristic features of form, because they have " features of manifest deliberate expressiveness " (Kendon 2004: 13–14, italics in the original). Kendon bases his definition of gestures on their articulatory movement characteristics and on their interactive perception. Following Kendon's descriptive approach, and by taking the form characteristics of gestures as a theoretical and methodological point of departure, a form-based and linguistic perspective to a grammar of gesture will be outlined. In doing so and by alluding to the study of signs it will be suggested that the study of gestures reveals how linguistic structures may emerge from body movement.


This paper documents the impact of a cash transfer programme – an initiative of the Government of Lebanon, the United Nations Children's Fund (UNICEF) and the World Food Programme (WFP), widely known as the No Lost Generation Programme (NLG) and, locally, as Min Ila ('from to') – on the school participation of displaced Syrian children in Lebanon. The programme provides cash to children who are enrolled in the afternoon shift of a public primary school. It was designed to cover the cost of commuting to school and to compensate households for income forgone if children attend school instead of working, two critical barriers to child school participation. We rely on a geographical regression discontinuity design comparing children living in two pilot governorates with children in two neighbouring governorates to identify the impact of the programme halfway in the first year of operation (the 2016/17 school year). We find limited programme effects on school enrollment, but substantive impacts on school attendance among enrolled children, which increased by 0.5 days to 0.7 days per week, an improvement of about 20 per cent over the control group. School enrollment among Syrian children rose rapidly across all of Lebanon's governorates during the period of the evaluation, resulting in supply side capacity constraints that appear to have dampened positive impacts on enrollment.


This Note considers the advisability of amending the False Claims Act's qui tam provisions beyond instances of fraud to include criminal allegations against government contractors employed overseas. It considers the negative effects that result from qui tam actions in the fraud context and discusses alternatives for holding contractors accountable for crimes committed overseas that could avoid those negative effects. This Note particularly focuses on and recommends a civilian corollary to the Military Extraterritorial Jurisdiction Act—the Civilian Extraterritorial Jurisdiction Act. It discusses the benefits that the Civilian Extraterritorial Jurisdiction Act would provide such as increased judicial efficiency, increased prosecutorial flexibility, and even protection of the contractors implicated as compared to the relatively uncertain option of local nations' laws. 592 WILLIAM & MARY BUSINESS LAW REVIEW [Vol. 5:591


Attempts to highlight quantitatively the growth and development of world literature in the field of pulsed laser deposition in terms of publication output as per Science Citation Index (1982-2006). During 1982-2006 a total of 8534 papers were published by the scientists in the field pulsed laser deposition. The average number of publications published per year was 341.36. The highest number of papers 1074 were published in 2005. There were 84 countries involved in the research in this field. USA is the top producing country with 2014 publications (19.35%) followed by Japan with 1553 publications (14.92%), Peoples-R-China with 1106 publications (10.63%), Germany with 763 publications (7.33%) South Korea with 694 publications (6.67%) and France with 615 publications (5.91%). India ranked 9 th among other countries with 291 publications during 1985-2006. Authorship and collaboration trend was towards multi-authored papers. There were 8338 (97.70%) multi-authored publications and 196 30 %) single authored publications. Chinese Academy of Sciences (Peoples-R-China) topped the list with 304 publications bollowed by Nanjing University (Peoples-R-China) with 244 publications, Tokyo Institute of Technology (Japan) with 233 publications and CNRS (France) with 217 publications. The most productive Indian institutions were: Tata Institute of Fundamental Research, Mumbai with 52 publications and Indian Institute of Science, Bangalore with 49 publications. The most prolific Indian authors were: R. Pinto (Indian-lnst-Technol-Bomaby, Mumbai) with 38 publications, M.S. Hegdc (Indian-Inst-Sci, Bangalore) with 31 publications, S.B. Ogale (Univ Pune, Pune) with 29 publications, L.M. Kukreja (Raja Ramanna Ctr-Adv-Technol, Indore) with 21 publications, P. Misra (Raja Ramanna Ctr-Adv-Technol, Indore) with 16 publications, R.K. Thareja (Indian-Inst-Technol-Kanpur) with 15 publications. The most preferred journals by the scientists were: Applied Physics Letters with 962 publications, Journal of Applied Physics with 714 publications, Applied Surface Science with 614 publications and Thin Solid Films with 541 publications.


The multiple effects in agriculture due to plant morphogenic conditions lead to the concern to search viable alternatives for the propagation and feasible development of crops. Therefore, it has had to resort to new techniques, such is the case of micropropagation techniques such as cuttings, which are based on the promotion and multiplication of plants, quickly, efficiently and in large quantities; due this reason it has been considered one of the most successful biotechnological methods in agriculture. The technique of cuttings results in a new plant identical to the plant from which it precedes; this quick and simple technique can be performed on most plants. One way of guaranteeing root development properly during micropropagation techniques is the use of certain growth regulators, of which the most used are the auxins, such as indole-3-acetic acids (AIA), Naphthaleneacetic acid (ANA) and indolbutyric acid (AIB). These auxins promote the initiation of roots and have been attributed the ability to stimulate cell divisions in the radicle. In addition to the auxins, the roots of the cuttings can be favored using treatments based on hormones, microorganisms and bioactive compounds. The morphogenic characteristics of the plants and the application of treatments, among other factors, contribute to the successful establishment of a crop.


The terms subjectification, intersubjectification and construction are very often used in relation to grammaticalisation, although the relationship between them is not always clear. Subjectification is said to occur both within grammaticalisation and out of it. Constructions, in turn, have recently been found to play a key role in grammaticalisation, to the point that it is now generally accepted that before an item is grammaticalised the construction in which it appears will first develop a grammatical function. The relationship between construction and subjectification has not been addressed directly, even though an important number of the examples of subjectification found in the literature are explained in terms of constructions in which the subjectifying element occurs. This paper aims to shed more light on how subjectification, grammaticalisation and constructions are related in the history of English, by paying special attention to verbs and verbo-nominal expressions of necessity from Old to Early Modern English. The findings will show that, in these items, the interrelationship between subjectification and grammaticalisation is not direct; that subjectification need not be unidirectional; and that constructions involving necessity items are the source of subjectification.


Purpose: Determination of need to orthodontic treatment is one of the main problems in our daily practice. Therefore, the aim of this study is to evaluate the orthodontic treatment needs of 12 – 13 year old students in Gorgan in years 2002-2003, using IOTN (index of orthodontic treatment need). Methods & Materials: A descriptive study using the technique of observation and interview has been performed by means of chart, ruler, tongue blade and color photographs of aesthetic component of IOTN. The method of sampling was cluster sampling and 793 individuals of urban and rural school children in Gorgan were examined. Results: According to dental health component (DHC) of ITON, 16.2 percent of school children showed great need and 16.9 percent moderate need to treatment and the frequency of slight or no need was 66.6 percent. The aesthetic component (AC) of IOTN in school children resulted in 7.1 percent great need, 20.9 percent moderate need and 71.9 percent no need. Conclusion: This study showed that the differences between IOTN values for boys and girls were not statistically significant the orthodontic treatment need in rural school children as significantly greater than urban school children, but most of them had no need or had slight need of orthodontic treatment. Beheshti Univ. Dent. J.2005;23(2):225-233


The article by Okoko and colleagues (1) in this issue of the Journal presents an interesting scenario. By its title, the article draws attention to the comparison with seminal work done between 1966 and 1972 when Sir Ian McGregor and colleagues monitored malaria infection at delivery and birth outcomes in more than 6,000 women in urban and rural parts of western Gambia (2). In a much smaller sample of women delivering during the rainy season in eastern Gambia in 1997, Okoko and colleagues observed very similar findings. In essence, nothing has changed in the 30 intervening years. The article by McGregor and colleagues, in combination with similar reports by others (3), led to discussions of the importance and appropriate approaches to the prevention of malaria in pregnancy. The World Health Organization (WHO) published recommendations for antimalarial chemoprophylaxis in pregnancy in 1986 (4) and noted the importance of an initial treatment dose, because many asymptomatic women were infected at the time of their first antenatal clinic visit. Studies elsewhere in Africa in the 1980s and 1990s showed the benefit of various treatment and or chemoprophylaxis regimens on the reduction of malaria, maternal anaemia, low birth-weight, and premature delivery (5,6). Work by others in the Gambia contributed to the growing recognition that effective interventions, including the use of antimalarial drugs (7,8) and insecticide-treated bednets (9), could be applied and could markedly reduce the adverse effects from malaria. Yet, good scientific inquiry and published articles have not led directly to changes in national policy and implementation of these policies at the local level. Okoko and colleagues note in their introduction that "the use of antimalarial chemoprophylaxis is still not uniformly practised in the Gambia," and they conclude that "a workable policy needs to be put in place." Recent studies in African settings have addressed the issue of a 'workable policy.' With the recognition that health systems have difficulty in delivering regular chemoprophylaxis to pregnant women (10), investigators in several settings demonstrated that intermittent preventive treatment (IPT) with effective and safe antimalarial drugs can achieve important reductions in frequency of malaria and its consequences (11,12). These interventions can be particularly cost-effective (13) and reduce the intolerable burden of malaria in pregnancy. The 20th WHO Expert Committee Report recommends, "intermittent treatment with an effective, preferably one-dose antimalarial drug delivered in the context of antenatal care should be made available to primi- and secundigravidae as an appropriate and effective method for reducing the consequences of malaria in pregnancy in highly-endemic areas." In follow-up of this guidance, dialogue between the malaria community and the reproductive health community is underway with the intent to incorporate the malaria-prevention strategy into antenatal care programmes widely in malarious areas of sub-Saharan Africa and to assure necessary supplies of drugs. Like all proven and important public-health prevention strategies, this will need continued attention and much advocacy from the malaria and reproductive-health community, and advocacy and demand from the mothers (and their babies) who will benefit. This approach using IPT has been facilitated by having sulphadoxine-pyrimethamine (SP) *, an antimalarial therapy that still has good efficacy in these semi-immune women, is a single-dose treatment, is not bitter, and is relatively well-tolerated. Importantly, studies of IPT with SP in pregnancy in numerous settings have clearly demonstrated its efficacy and effectiveness in programmes (6). Because of the single-dose treatment, the effectiveness of the programme essentially matches the efficacy of the drug as long as health workers can give it under observation in the clinic. If and when we have to move from SP to alternative drugs or drug combinations that require multi-day dosing, this will be more challenging (i. …


The rigorous characterization of ultrahigh-frequency passive radio-frequency identification (RFID) tags is a challenging but mandatory task. Indeed, tags are the most critical devices in RFID systems: their performance should be adequately good, although stringent requirements in terms of compactness, used materials, and costs must be satisfied. Factors such as the goodness of the conjugate impedance matching between the chip and the antenna, the chip sensitivity, and the quality of the backscattered signal affect tag performance. Tag sensitivity and differential radar cross section (RCS) are the most significant metrics for tag characterization: they define the forward (from the reader to the tag) and the backward (from the tag to the reader) link reliability, respectively. Nevertheless, measurement of such metrics cannot be approached with conventional methods based on vector network analyzers or conventional RFID readers. Vice versa, commercially available instrumentation and solutions are very expensive and not totally flexible. In this paper, a novel approach for performance characterization of RFID tags is explored. To this end, we developed a very cheap (below $1000) and flexible tool based on software-defined radio, which enables measurement of tag sensitivity and differential RCS. An exhaustive experimental campaign has been carried out on ten commercial and four built-in laboratory RFID tags. Achieved results demonstrate the flexibility, accuracy, and appropriateness of the proposed approach.


This dissertation celebrates the portable one-volume Latin Vulgate bibles produced on an unprecedented scale during the 13th century, particularly between 1230 and 1280, emphasizing their particular significance within the contexts of medieval book production and medieval bible use. The profound changes that these bibles implemented to the physical appearance and format of the Bible (as compact and portable copies of the complete biblical text), generated great innovations in the function and use of the Bible, and were directly responsible for the 13th-century portable bible's extraordinary success and enduring popularity, in its own time and in ours, and thus their privileged place in the history of the Bible and the broader histories of medieval manuscripts and the Book. I begin by positioning these bibles within contemporary trends of bible production, use and users at the time of their emergence in the early 13th century, comparing and contrasting their respective sizes, formats, texts, scripts, layouts and decoration, before proceeding, in my second chapter to examine the strategies of compression and miniaturization – including the use of thinner parchment, the miniaturization of their writing and the compression of the graphic unit of their mise-en-page that made it possible to produce the whole Bible in Portable Book Format. In my third chapter I turn to study how and why the 13th-century portable bible functioned as an independent searchable reference tool, and how these factors made these books invaluable for use for study and preaching, in addition to inviting liturgical use. Chapter 4 locates the portable bible within the early professional book trade, considers the production and early ownership of 'luxury' copies and offers a study of the costs involved in the 'bespoke' production of portable bibles (in the 13th century) and a survey of recorded prices of sale and purchase for which copies changed hands on the second hand book market (through the 16th century). In my fifth and final chapter I investigate the position of 13th-century portable bibles in late medieval libraries and book collections focusing on the late medieval use of pandect bibles in two Benedictine communities, those at Durham Cathedral and at St. Augustine's Abbey, Canterbury, concluding with a discussion of the places and pusrposes of these books in other religious institutions, illustrated through an extensive survey of medieval catalogues, inventories, wills and booklists. Degree Type Dissertation Degree Name Doctor of Philosophy (PhD) Graduate Group English This dissertation is available at ScholarlyCommons: http://repository.upenn.edu/edissertations/1684 First Advisor David J. Wallace


A new approach to comparative modeling of proteins, TRACER, is described and benchmarked against classical modeling procedures. The new method unifies true three-dimensional threading with coarse-grained sampling of query protein conformational space. The initial sequence alignment of a query protein with a template is not required, although a template needs to be somehow identified. The template is used as a multi-featured fuzzy three-dimensional scaffold. The conformational search for the query protein is guided by intrinsic force field of the coarse-grained modeling engine CABS and by compatibility with the template scaffold. During Replica Exchange Monte Carlo simulations the model chain representing the query protein finds the best possible structural alignment with the template chain, that also optimizes the intra-protein interactions as approximated by the knowledge based force field of CABS. The benchmark done for a representative set of query/template pairs of various degrees of sequence similarity showed that the new method allows meaningful comparative modeling also for the region of marginal, or non-existing, sequence similarity. Thus, the new approach significantly extends the applicability of comparative modeling.


The grid computing paradigm is replacing localized computer clusters or the traditional "supercomputer" model for research and industry enterprises requiring increasingly large amounts of processing power and storage. Computational grids are distributed systems integrating geographically- separate resources into a single, massively parallel network well-suited to complex processing tasks. This article introduces grid computing, lays out a taxonomy for comparing and analyzing the existing grid resource management systems, discusses the optimization and coordination of computational grids, and presents quantitative methods for managing grid resources. Local scheduling, external scheduling, and coordination of grid endpoints are highlighted as methods of resource management. Techniques and ongoing research projects are also discussed for improving the economy of resource bundles in flat, hierarchal, and cell structure grids.


Protein loss, manifested as loss of muscle mass, is observed universally in all critically ill patients. Depletion of muscle mass is associated with impaired function and poor outcomes. In extreme cases, protein malnutrition is manifested by respiratory failure, lack of wound healing, and immune dysfunction. Protecting muscle loss focused initially on meeting energy requirements. The assumption was that protein was being used (through oxidation) as an energy source. In healthy individuals, small amounts of glucose (approximately 400 calories) protect muscle loss and decrease amino acid oxidation (protein-sparing effect of glucose). Despite expectations of the benefits, the high provision of energy (above basal energy requirements) through the delivery of nonprotein calories has failed to demonstrate a clear benefit at curtailing protein loss. The protein-sparing effect of glucose is not clearly observed during illness. Increasing protein delivery beyond the normal nutrition requirements (0.8 g/k/d) has been investigated as an alternative solution. Over a dozen observational studies in critically ill patients suggest that higher protein delivery is beneficial at protecting muscle mass and associated with improved outcomes (decrease in mortality). Not surprisingly, new Society of Critical Care Medicine/American Society for Parenteral and Enteral Nutrition guidelines and expert recommendations suggest higher protein delivery (>1.2 g/kg/d) for critically ill patients. This article provides an introduction to the concepts that delineate the basic principles of modern medical nutrition therapy as it relates to the goal of achieving an optimal management of protein metabolism during critical care illness, highlighting successes achieved so far but also placing significant challenges limiting our success in perspective.


The mechanism by which Ca2+ mediates gene induction in response to membrane depolarization was investigated. The adenosine 3',5'-monophosphate (cAMP) response element-binding protein (CREB) was shown to function as a Ca(2+)-regulated transcription factor and as a substrate for depolarization-activated Ca(2+)-calmodulin-dependent protein kinases (CaM kinases) I and II. CREB residue Ser133 was the major site of phosphorylation by the CaM kinases in vitro and of phosphorylation after membrane depolarization in vivo. Mutation of Ser133 impaired the ability of CREB to respond to Ca2+. These results suggest that CaM kinases may transduce electrical signals to the nucleus and that CREB functions to integrate Ca2+ and cAMP signals.


Aims: The emotional schema model emphasizes on evaluation and interpretation of emotions and emotion regulation strategies. This study aimed to determine the effectiveness of Emotional Schema Therapy (EST) on decrease of Post-event rumination and cognitive avoidance in people with clinical symptoms of social anxiety. Materials & Methods: This is a semi-experimental study with a pretest-posttest control group. For this purpose, 32 students with clinical symptoms of social anxiety were screened with the cut-off point of the Social Phobia Inventory (SPIN) and clinical interviews and were randomly assigned to experimental and control groups. The Post Event Processing Questionnaire (PEPQ) and Cognitive Avoidance Questionnaire (CAQ) were used to collect data in two conditions (pretest and posttest). Experimental group experienced 10 weeks of emotional schema therapy, while the control group received no treatment. Data were analyzed using SPSS software (ver 23) and Multivariate Analysis Of Covariance (MANCOVA). Findings: The average of post-event rumination and cognitive avoidance were reduced in the experimental group in posttest. After controlling the effect of pretest scores, there were significant differences between the test and control groups in terms of all variables (p<0.001). Conclusion: Emotional Schema Therapy due to the emphasis on the role of the individual beliefs and strategies about emotions can be used as an effective intervention in order to reduce symptoms of social anxiety, for example the Postevent rumination and cognitive avoidance in the people with clinical symptoms of social anxiety.


This paper discusses the main operating features of hoods with conical diaphragms. The hoods can successfully be used as part of a topographic apparatus complex placed on board spacecraft for imaging of the earth's surface. The geometrical and physical characteristics of the hoods are investigated on the basis of criteria for evaluating the efficiency. Certain features of the functioning when the wave properties of light are taken into account are described. © 2005 Optical Society of America


For more than a decade, habitat mapping using biotopes (in‐channel hydraulically‐defined habitats) has underpinned aquatic conservation in the UK through (a) providing baseline information on system complexity and (b) allowing environmental and ecological change to be monitored and evaluated. The traditional method used is the subjective river habitat or corridor survey. This has recently been revised to include the floodplain via GeoRHS, but issues still exist concerning development of a national database due to the labour intensive nature of the data collection, subjectivity issues between samplers, temporal changes, the fuzzy nature of perceived habitats and habitat boundaries. This paper takes an innovative approach to biotope definition using high resolution spatial data to define water surface roughness for two representative reaches of the River South Tyne, Cumbria, and the River Rede, Northumberland, UK. Data was collected using a terrestrial laser scanner (TLS) and hydraulic variability simply expressed through assigning a local standard deviation value to a set of adjacent water surface values. Statistical linkage of these data with biotope locations defined visually in the field allowed complete mapping of the surveyed reach defining habitat and biotope areas to the fine scale resolution of the TLS data. Despite issues of data loss due to absorption and transmission through the water, the reflected signal generated an extremely detailed and objective map of the water surface roughness, which may be compared with known biotope locations as defined by visual identification in the field. The TLS accuracy achieved in the present study is comparable with those obtained using hyperspectral imagery: with 84% of the pool/glide/marginal deadwater amalgamated biotope, 88% of riffles, 57% of runs and 50% of the amalgamated cascade/rapid biotope successfully plotted. It is clear from this exercise that biotope distribution is more complex than previously mapped using subjective techniques, and based upon the water surface roughness delimiters presented in this study, the amalgamation of pools with glides and marginal deadwaters, riffles with unbroken standing waves, and cascades with rapids, is proposed. Copyright © 2010 John Wiley & Sons, Ltd


Empirical auto-tuning and machine learning techniques have been showing high potential to improve execution time, power consumption, code size, reliability and other important metrics of various applications for more than two decades. However, they are still far from widespread production use due to lack of native support for auto-tuning in an ever changing and complex software and hardware stack, large and multi-dimensional optimization spaces, excessively long exploration times, and lack of unified mechanisms for preserving and sharing of optimization knowledge and research material.We present a possible collaborative approach to solve above problems using Collective Mind knowledge management system. In contrast with previous cTuning framework, this modular infrastructure allows to preserve and share through the Internet the whole auto-tuning setups with all related artifacts and their software and hardware dependencies besides just performance data. It also allows to gradually structure, systematize and describe all available research material including tools, benchmarks, data sets, search strategies and machine learning models. Researchers can take advantage of shared components and data with extensible meta-description to quickly and collaboratively validate and improve existing auto-tuning and benchmarking techniques or prototype new ones. The community can now gradually learn and improve complex behavior of all existing computer systems while exposing behavior anomalies or model mispredictions to an interdisciplinary community in a reproducible way for further analysis. We present several practical, collaborative and model-driven auto-tuning scenarios. We also decided to release all material at c-mind.org/repo to set up an example for a collaborative and reproducible research as well as our new publication model in computer engineering where experimental results are continuously shared and validated by the community.


Grain storage is an important problem for both farmers and grain merchants; however, it is especially central to the success of the grain merchandizing companies because the time, price, and quantity of both the commodity purchases as well as sales determine the company's profitability over a specific time. Since commodity storage is a finite resource, merchandizers have to dynamically allocate its capacity among competing commodities in face of uncertainty, considering opportunity cost at all times. Important decision making steps can be described as follows: which grain, how much of it, and at what price one should buy in order to sell it profitably in the future while at the same time lining up the capacity for the next commodity's quantity with a given price. Studies focus on on-site storage for farmers, and many research and extension programs investigate the optimal timing of sales (Musser, 1996; Lai et al., 2003; Kadjo, 2013). However, no studies analyze the storage allocation problem for a grain merchandizing line of business, with such attributes as handling more than one grain and operating under price volatility, various harvesting cycles, and a limited storage capacity. This study incorporates price distributions based on historical data to solve the optimal grain storage problem for a grain merchandizer. An optimal partial selling rule is derived in the model allowing optimal allocation to spread sales out over the storage period.


The status of the 15 species of Asterolecaniidae previously described or recorded from South Africa is reviewed, and the adult female and immature stages of a new species, Asterolecanium endroedyi, are described. Several species are transferred to other genera, representing new combinations, i.e. Asterodiaspis borboniae (Brain), A. brevispinum (Brain), Russellaspis brachylenae (Brain), R. conspicuum (Brain), R. euryopis (Fuller), R. euphorbiae (Russell) and R. proteae (Giliomee & Munting). Lectotypes have been designated for A. brevispinum, Planchonia stentae (Brain), R. brachylenae, R. conspicuum, and R. euryopis. Keys to the adult females of the genera and species of Asterolecaniidae known from South Africa based on the adult female are provided.


The theory of twistors and the theory of integrable models have, for many years, developed independently of each other. However, in recent years it has been shown that there is considerable overlap between these two apparently disparate areas of mathematical physics. The aim of this thesis is twofold; firstly to show how many known integrable models may be given a natural geometrical/twistorial interpretation, and secondly to show how this leads to new integrable models, and in particular new higher dimensional models. After reviewing those elements of twistor theory that are needed in the thesis, a generalisation of the Yang-Mills self-duality equations is constructed. This is the framework into which many known examples of integrable models may be naturally fitted, and it also provides a simple way to construct higher dimensional generalisations of such models. Having constructed new examples of (2 + l)-dimensional integrable models, one of these is studied in more detail. Embedded within this system are the sine-Gordon and Non-Linear Schrodinger equations. Some solutions of this (2 + l)-dimensional integrable model are found using the 'Riemann Problem with Zeros' method, and these include the sohton solutions of the SG and NLS equations. The relation between this approach and one based the Atiyah-Ward ansatze is dicussed briefly. Scattering of localised structures in integrable models is very different from scattering in non-integrable models, and to illustrate this the scattering of vortices in a modified Abelian-Higgs model is considered. The scattering is studied, for small speeds, using the 'slow motion approximation' which involves the calculation of a moduli space metric. This metric is found for a general TV-lump vortex configuration. Various examples of scattering processes are discussed, and compared with scattering in an integrable model. Finally this geometrical approach is compared with other approaches to the study of integrable systems, such as the Hirota method. The thesis closes with some suggestions for how the KP equation may be fitted into this geometrical/twistorial scheme.


In February-March 2007 PMGE, VNIIOkeangeologia and AWI conducted a joint geophysical survey in the area between the Prydz Bay and the southern Kerguelen Plateau (SKP) using two research vessels. Totally 5 000 km of MCS, gravity and magnetic profiles, 37 OBS records (along two N-S oriented MCS lines) and about 8000 km of detailed helicopter magnetic lines (in two local corridors centered on MCS-OBS profiles) have been acquired. Additionally two-ship (long-aperture) seismic experiment has been carried out along the 72.7E MCS-OBS line. Conducted investigations enabled definition crustal characteristics of this region, mapping principal tectonic provinces and features and development a seismic stratigraphy model. Major preliminary outcomes of the study are following: 1) the COB off Prydz Bay is marked by emplacements of mantle rocks into the lower crust (incomplete mantle unroofing) and is located 20-70 km southward of the prominent linear magnetic anomaly (Mac. Robertson Coast Anomaly); this anomaly might reflect a more active melt production during initial emplacement of the Kerguelen Plume into the oceanic lithosphere; 2) oceanic crust between 68E and 76E shows symmetric consequences of M-series magnetic anomalies with proposed extinct spreading centers implying paleoridge jumps; the SKP was probably isolated from India margin during this event and is underlain by extended continental crust; 3) flat-lying terrace with thickened (10-11 km) magmatic crust was recognized around the major morphological elevation of the SKP.


Climate change in the Nordic countries is projected to lead to both wetter and warmer seasons. This, in combination with associated vegetation changes and increased animal migration, increases the potential incidence of tick-borne diseases (TBD) where already occurring, and emergence in new places. At the same time, vegetation and animal management influence tick habitat and transmission risks. In this paper, we review the literature on Ixodes ricinus, the primary vector for TBD. Current and projected distribution changes and associated disease transmission risks are related to climate constraints and climate change, and this risk is discussed in the specific context of reindeer management. Our results indicate that climatic limitations for vectors and hosts, and environmental and societal/institutional conditions will have a significant role in determining the spreading of climate-sensitive infections (CSIs) under a changing climate. Management emerges as an important regulatory "tool" for tick and/or risk for disease transfer. In particular, shrub encroachment, and pasture and animal management, are important. The results underscore the need to take a seasonal view of TBD risks, such as (1) grazing and migratory (host) animal presence, (2) tick (vector) activity, (3) climate and vegetation, and (4) land and animal management, which all have seasonal cycles that may or may not coincide with different consequences of climate change on CSI migration. We conclude that risk management must be coordinated across the regions, and with other land-use management plans related to climate mitigation or food production to understand and address the changes in CSI risks.


This paper is divided into three parts. In the first (section 1), we demonstrate that all of quantum mechanics can be derived from the fundamental property that the propagation of a matter wave packet is described by the same gravitational and kinematic time dilation that applies to a clock. We will do so in several steps, first deriving the Schroedinger equation for a nonrelativistic particle without spin in a weak gravitational potential, and eventually the Dirac equation in curved space-time describing the propagation of a relativistic particle with spin in strong gravity.
In the second part (sections 2-4), we present interesting consequences of the above quantum mechanics: that it is possible to use wave packets as a reference for a clock, to test general relativity, and to realize a mass standard based on a proposed redefinition of the international system of units, wherein the Planck constant would be assigned a fixed value. The clock achieved an absolute accuracy of 4 parts per billion (ppb). The experiment yields the fine structure constant $\alpha = 7.297\,352\,589(15) \times 10^{-3}$ with 2.0 ppb accuracy. We present improvements that have reduced the leading systematic error about 8-fold and improved the statistical uncertainty to 0.33 ppb in 6 hours of integration time, referred to $\alpha$.
In the third part (sections 5-7), we present possible future experiments with atom interferometry: A gravitational Aharonov-Bohm experiment and its application as a measurement of Newton's gravitational constant, antimatter interferometry, interferometry with charged particles, and interferometry in space.
We will give a review of previously published material when appropriate, but will focus on new aspects that haven't been published before.


Before using CORBA (Common Object Request Broker Architecture) applications in mission-critical scenarios, it is important to understand the robustness of the Object Request Broker (ORB) being used, which forms the platform for CORBA applications. We have extended the Ballista software testing technique to test the exception-handling robustness of C++ ORB client-side application interfaces, and have tested two major versions of three ORB implementations on two operating systems, yielding robustness failure rates ranging from 26% to 42%. To improve ORB robustness, we also propose a probing method to harden object and pseudo-object related data types against exceptional inputs. Using these probes on omniORB 2.8 has proven to be effective in eliminating some cases of robustness failures found during testing. These results suggest that CORBA implementations currently have significant robustness vulnerabilities, but that some important classes of problems can be overcome with better exception-handling approaches.


Abstract Web-based discussion fora proliferate on the Internet. These fora consist of threads about specific matters. Existing forum search facilities provide an easy way for finding threads of interest. However, understanding the content of threads is not always trivial. This problem becomes more pressing as threads become longer. It frustrates users that are looking for specific information and also makes it more difficult to make valuable contributions to a discussion. We postulate that having a concise summary of a thread would greatly help forum users. But, how would we best create such summaries? In this paper, we present an automated method of summarising threads in discussion fora. Compared with summarisation of unstructured texts and spoken dialogues, the structural characteristics of threads give important advantages. We studied how to best exploit these characteristics. Messages in threads contain both explicit and implicit references to each other and are structured. Therefore, we term the threads hierarchical dialogues. Our proposed summarisation algorithm produces one summary of an hierarchical dialogue by 'cherry-picking' sentences out of the original messages that make up a thread. We try to select sentences usable for obtaining an overview of the discussion. Our method is built around a set of heuristics based on observations of real fora discussions. The data used for this research was in Dutch, but the developed method equally applies to other languages. We evaluated our approach using a prototype. Users judged our summariser as very useful, half of them indicating they would use it regularly or always when visiting fora.


There are many land management scenarios where chemicals are not the ideal choice for controlling invasive plants. More often than not, the best approach is the use of integrated pest management involving a variety of control methods. Maximizing the value of mechanical, manual, and cultural control methods with the added benefit of selective herbicides can offer the best results in many situations. It is important to choose durable and tested tools when utilizing manual and mechanical control as these labor intensive methods can be very time consuming. Down time due to use of inadequate tools can result in missed deadlines and often in poor mortality rates which require expensive retreatments. Land managers should also be aware of cultural methods of integrated pest management which are often overlooked. Mulching, soil solarization with plastic film, thermal weed control, water level manipulations, prescribed burning, and prescribed grazing are cultural methods that can play a key role in the reduction of invasive plant populations.


A layered wireless network is considered, where information is transmitted in a multi-hop MIMO-like fashion from the source node layer through several intermediate layers of nodes before reaching the sink node layer. Analog network coding is investigated as the network transmission strategy, exploiting the inherent superposition features of the wireless channel. A general myopic transmission protocol is proposed, allowing overhearing across several layers. Special cases are investigated in terms of diversity and bit error rate when using different types of linear detectors. Conditions for successful decoding of all source node messages at each sink node are derived.


McGraw-Hill is proud to introduce the Hinkle et al., "Office 2010: A Lesson Approach Series". Utilizing the author team of Deborah Hinkle, Kathleen Stewart, John Carter and Pat Graves from the former "Professional Approach Series for Microsoft Office", this "Office 2010: Lesson Approach" series provides a fresh, clear, modular introduction of Microsoft Office 2010 skills. It's 'Learn by Doing' theme is incorporated in each lesson so students can experience hands-on learning throughout the entire text. Students first focus on the introductory skills that are isolated in each lesson and then complete individual skill exercises that ensure a clear learning path. The application case studies provide even more context to the student so they can better associate lesson goals and themes. This text also correlates with SimNet Online for Office 2010, our online training and assessment program, and also SimGrader, our online project grader component which contains a full project library including projects from this "Lesson Approach Series" and also projects from our other "Microsoft Office 2010" textbook series. Together, SimNet and SimGrader provide the complete solution for today's student learning Microsoft Office 2010.


JENNIFER B. OLIVER The Prevalence of Nelson Bay Virus in Humans and Bats and Its Significance within the Framework of Conservation Medicine (Under the direction of KAREN GIESEKER, FACULTY MEMBER) Public health professionals strive to understand how viruses are distributed in the environment, the factors that facilitate viral transmission, and the diversity of viral agents capable of infecting humans to characterize disease burdens and design effective disease intervention strategies. The public health discipline of conservation medicine supports this endeavor by encouraging researchers to identify previously unknown etiologic agents in wildlife and analyze the ecologic of basis of disease. Within this framework, this research reports the first examination of the prevalence in Southeast Asia of the orthoreovirus Nelson Bay virus in humans and in the Pteropus bat reservoir of the virus. Contact with Pteropus species bats places humans at risk for Nipah virus transmission, an important emerging infectious disease. This research furthermore explores the environmental determinants of Nelson Bay and Nipah viral prevalence in Pteropus bats and reports the characterization of two novel orthoreoviruses isolated from bat tissues collected in Bangladesh. INDEX WORDS: Nelson Bay virus, Orthoreovirus, Nipah virus, Emerging infectious disease, Conservation medicine, Megachiropterans, Bats, Bangladesh THE PREVALENCE OF NELSON BAY VIRUS IN HUMANS AND BATS AND ITS SIGNIFICANCE WITHIN THE FRAMEWORK OF CONSERVATION MEDICINE


China's accession to the WTO requires a great many specific policy reforms. However, if the best results are to be obtained, it is important that these reforms be implemented as part of a consistent development program, rather than simply by treating them as a recipe. To do this, policy makers must understand the range and nature of the policy changes required by accession, their implications for the economy, and the availability and effects of supporting policies. "China and the WTO" analyzes the nature of the reforms involved in China's accession to the WTO, assesses their implications for the world economy, and examines the implications for individual households, particularly the poor. Its key objective is to provide the information that will allow policy makers to implement WTO commitments and formulate supporting policies to contribute strongly to economic development and poverty reduction. Individual chapters by leading scholars analyze the nature of the reforms in key areas, such as agriculture, services, intellectual property and safeguards and anti-dumping. These chapters form the building blocks for later chapters, which analyze the implications of reform for the economy. The book also includes a series of studies that assess the implications for households, taking into account the social safety net policies applying in China, and the impacts of complementary policies in areas such as labor market reform and investments in human capital.


The objective of this research is the analysis of road safety attitudes and perceptions of motorcyclists with respect to riding a motorcycle while impaired (i.e. by alcohol, drugs / medication or fatigue) in Europe. Data are collected from the European SARTRE-4 survey, co-funded by the European Commission, which was conducted in 19 European countries. A total sample of 4,483 motorcyclists was interviewed in total, using a common questionnaire, with questions on road safety attitudes, perceptions, beliefs, motives etc. The present study allowed to identify differences in attitudes towards alcohol, medication and fatigue impaired riding, between groups of motorcyclists and different countries, and to assess the perceived impact of related road safety measures (e.g., legal blood alcohol concentration, breath testing and alcohol interlock) on intended behaviour.


Information and communication technologies (ICTs) are playing increasingly important roles in the day-to-day lives of people, revolutionizing their work and leisure, and changing rules of doing businesses. Development of ICT leads up to E-governance, which has now become the most talked word around the world. In this paper, we have done the study on the various e-government projects across India with a view to explore the natures of implementations of these projects, benefits imparted from them to citizens and their up- and down-sides.


Oridonin, an ent-kaurene diterpenoid extracted from the traditional Chinese herb Rabdosia rubescens, has multiple biological and pharmaceutical functions and has been used clinically for many years. While the antitumor function of oridonin has been corroborated by numerous lines of evidence, its anticancer mechanism has not been well documented. In this study, the pancreatic cancer cell line BxPC-3 was used as a model to investigate a possible anticancer mechanism of oridonin through examining its effects on cell viability. The results showed that oridonin affected cell viability in a time- and dose-dependent manner. After exposure to different oridonin concentrations, growth rates and cell cycle arrest of BxPC-3 cells were significantly reduced compared with untreated cells, suggesting its effects on proliferation inhibition. Detailed signaling pathway analysis by western blot analysis revealed that low-dose oridonin treatment inhibited BxPC-3 cell proliferation by up-regulating p53 and down-regulating cyclin-dependent kinase 1 (CDK1), which led to cell cycle arrest in the G2/M phase. A high-dose oridonin not only arrested BxPC-3 cells in the G2/M phase but also induced cell accumulation in the S phase, presumably through γH2AX up-regulation and DNA damage. In addition, our results showed that a cell subpopulation was stained with propidium iodide after oridonin treatment. Protein quantification showed that cleaved poly(ADP-ribose) polymerase (PARP) expression was increased after a high-dose oridonin treatment, especially after long-term exposure. Accompanied by the increased level of deactivated PARP in BxPC-3 cells, the apoptosis initiators caspase-3 and caspase-7 expressions were also significantly increased, suggesting that caspase-mediated apoptosis contributed to cell death.


Despite a large volume of research examining instructional strategies and student learning, very little research has examined relationships between students' perceptions of the value of specific instructional techniques and academic motivation. In the current research, college students (172 undergraduates) completed scales assessing the perceived value of course websites, active learning, and traditional lectures, as well as the Academic Motivations Inventory (AMI; Moen & Doyle, 1977). Results showed a complex pattern of significant correlations that was simplified when examining the three key factors of academic motivation. Specifically, stepwise regression analysis showed that engagement was positively related with the perceived value of all three instructional techniques, whereas avoidance was not significantly related with any. Achievement motivation was positively related with the perceived value of traditional lectures. These results suggest that students with different types of academic motivation respond differently to specific instructional techniques and that a variety of strategies may need to be activated to reach all students. Implications for future research and practice are discussed. Key Words: academic motivation, instructional techniques, course websites ********** In order to enhance the value of a college education, it is important to identify the relationship between students' receptiveness to various instructional techniques and individual differences in academic motivation. Teachers and scholars have long been attentive to how the choice of specific teaching techniques (such as lectures, assignments, and experiential exercises) may impact classroom climate and performance (McKeachie, 1974). However, relationships between specific instructional techniques and student motivation have received less attention (Hammer, 2005). In addition, in recent years, many university faculty have developed comprehensive course websites that provide access to lecture notes, grades, review sheets, example exam questions, links, and so on. With the advent of the internet and increased use of course websites, it is becoming increasingly important to determine the impact of website usage on student motivation and learning (Cox & Rogers, 2005; Roblyer & Knezek, 2003). Indeed, Robinson (2004) reports that as students become more connected to the electronic world, faculty members will find themselves compelled to incorporate technology in the classroom. Similarly, Miller, Martineau, and Clark (2000) conclude that educators have very little choice but to incorporate technology as widespread student computer usage expands and social, structural, and resource barriers inevitably diminish. Similarly, Grasha (2000) encourages faculty to develop a conceptual framework for incorporating technology in the classroom, as it is important for faculty to explore the fit between technology and their philosophy of teaching and learning. Thus, it is important to develop an understanding of how the mix of instructional technologies employed is related to students' motivation, learning, and performance. We designed the current research to examine the relationship between the perceived value of different teaching techniques and college students' academic motivation. Specifically, we focused on the relationships that course website usage, traditional lecture, and active learning techniques have with distinct aspects of academic motivation. Theoretical Background We propose that instructional techniques do not impact all students equally, and that students with different profiles of academic motivation will prefer and value different instructional techniques. For years, scholars across numerous disciplines have analyzed various instructional methods and sought to identify those that are most effective. This prior research and theory suggests that pedagogical choices can have a significant impact on student learning, eagerness to consider new information, and ability to apply information to new situations. …


A key contention of the transitional justice movement is that the more comprehensive and vigorous the effort to bring justice to a departed authoritarian regime the better the democratizing outcome will be. This essay challenges this view with empirical evidence from the Iberian Peninsula. In Portugal, a sweeping policy of purges intended to cleanse the state and society of the authoritarian past nearly derailed the transition to democracy by descending into a veritable witch-hunt. In Spain, by contrast, letting bygones be bygones, became a foundation for democratic consolidation. These counter-intuitive examples suggest that there is no pre-ordained outcome to transitional justice, and that confronting an evil past is neither a requirement nor a pre-condition for democratization. This is primarily because the principal factors driving the impulse toward justice against the old regime are political rather than ethical or moral. In Portugal, the rise of transitional justice mirrored the anarchic politics of the revolution that lunched the transition to democracy. In Spain, the absence of transitional justice reflected the pragmatism of a democratic transition anchored on compromise and consensus.


Resolving the genetic connectivity of coral reef taxa is necessary to understand the community dynamics of these increasingly threatened ecosystems. Herein, we assess the fine scale genetic connectivity of six populations of the Atlantic giant barrel sponge, Xestospongia muta (Schmidt, 1870), using microsatellite markers. This survey included populations from across the Florida Reef Tract and the Gulf of Mexico, including sponges from the Pulley Ridge Habitat Area of Particular Concern, a mesophotic coral reef located approximately 250 km from Florida's (USA) southwestern coast, and the Flower Garden Banks National Marine Sanctuary, the northernmost western Atlantic coral reef ecosystem. Overall, significant population structure was found (F ST = 0.020, 95% CI: 0.011–0.031), with X. muta individuals from the Flower Garden Banks showing the highest levels of genetic differentiation relative to all other surveyed populations (F ST > 0.048). Despite the high levels of population structuring observed, some horizontal and/ or vertical connectivity was found between neighboring reef systems, including evidence of gene flow between mesophotic (Pulley Ridge Habitat of Particular Concern) and photic (Dry Tortugas) reef tracts. Furthermore, largely negligible levels of first-generation migration among discrete genetic populations was observed, suggesting that the persistence of most populations of X. muta is highly dependent on self-recruitment. Thus, while the Pulley Ridge mesophotic reef may provide sponge recruits to shallow photic reefs, its role as a potential refuge and propagule source appears limited to only small geographic scales.


We present results from four GPS campaigns in the broader Kaparelli–Asopos area in central Greece. This area is undergoing extension as demonstrated by seismological, geodetic and geological data. The east-west striking Kaparelli normal fault ruptured during the March 4, 1981, M = 6.3 earthquake and created km-long surface breaks with the downthrown side to the south. The geodetic results include: determination of station coordinates in the ITRF 2005 frame, computation of station velocities with respect to stable Europe and strain rate tensor estimates. The pattern of velocities along the east-west direction (parallel to the rift axis; 40 km E-W × 12 km N-S) and azimuth of strain axes are compared to geological data and to other GPS results in central Greece. We find that strain in this region consists of an amount of shortening (66 ns/yr) in the direction approximately N 58°E, and about three times more extension (187 ns/yr) at N 32°W. A large change in strain orientation (from NW to NNE) is observed from west to east, along the active faults of Asopos rift in agreement with fault slip data. This change signifies the need for using local GPS networks to map local strain rate patterns in actively extending regions of Greece.


The spatial turn will be considered through three case studies involving digital data. Each case considers technological agency in the articulation of space and place. The first two cases will involve the conception of the DigiLab, — from its online case study research (which involved a landscape review of digital research centres, networks and labs and studios worldwide), to its architectural construction as a space located on the ground floor of the London College of Communication. The third case will explore the geo-spatial user-interface design research that required a collaborative studio practice before the DigiLab was built.

In the 1960s Robert Sommer and Edward T. Hall posed questions around design, 'personal space' (1969) and 'proxemics' (1964). Neither took into consideration the role of technological agency in the articulation of their spatial questions. Further spatial preoccupations occur in the 1980-90s through the de-territorialisation and re-territorialisation maneuvers of Gilles Deleuze and Felix Guattari ([1988] 2004), as well as the interest in the non-place by Marc Auge (1995). These articulations of space and place will be traced through the case studies to understand the spatial turn in STS.

The concept will be explored as a discussion of territoriality and emergence referring to the 'emergent historic' (Berlant 2011) by way of 'intra-action' (Barad 2003). Independently, each case articulates the spatial turn as the emergent historic. Interweaved, however, the spatial articulations of the DigiLab (media and design lab) emerge alongside the geo-spatial research undertaken and vice-versa (as a simultaneous matter of intra-action).


Multitask reinforcement learning (MTRL) suffers from scalability issues when the number of tasks or trajectories grows large. The main reason behind this drawback is the reliance on centeralised solutions. Recent methods exploited the connection between MTRL and general consensus to propose scalable solutions. These methods, however, suffer from two drawbacks. First, they rely on predefined objectives, and, second, exhibit linear convergence guarantees. In this paper, we improve over state-of-the-art by deriving multitask reinforcement learning from a variational inference perspective. We then propose a novel distributed solver for MTRL with quadratic convergence guarantees.


Background: E-health solutions are increasingly being developed to meet patients' preferences and promote their participation in healthcare. Few studies have explored the participatory design process from the perspective of person-centeredness, including how it becomes materialized in technology. This paper explores how applied participatory approaches and the design of 4 web-based interventions directed towards long-term illness correspond to key areas of person-centeredness.  Methods: Data were collected during 2009 to 2012, from 4 Swedish research projects. The analysis followed an inductive approach involving a step-wise cross-case analysis. The purpose was to create shared knowledge and understanding of each separate case and to generate relevant categories. Results: A number of question areas describe the dialogue with the case participants. Results of the dialogue are categorized into 4 support areas: psychological/emotional, personal, information and technical. Person-centeredness becomes visible in the participatory design process as the approach promotes the development of a holistic view of the person and the illness and a partnership between patients and carers. The use of communication technology exemplifies concrete materialization of person-centeredness in the design of the web-based supports. The purpose of the web supports and the shaping of the actual use of the functionalities are more abstract forms of materialization. Conclusions: Our results contribute to a central development area within eHealth involving increased opportunities for patients to contribute actively in real time, obtaining access to information and sometimes interacting with carers. However, neither participatory approaches nor technology for online information and communication, can guarantee person-centeredness in isolation.


Given a sequence of convex functions $f_0, f_1, \ldots, f_T$, we study the problem of sampling from the Gibbs distribution $\pi_t \propto e^{-\sum_{k=0}^tf_k}$ for each epoch $t$ in an online manner. Interest in this problem derives from applications in machine learning, Bayesian statistics, and optimization where, rather than obtaining all the observations at once, one constantly acquires new data, and must continuously update the distribution. Our main result is an algorithm that generates roughly independent samples from $\pi_t$ for every epoch $t$ and, under mild assumptions, makes $\mathrm{polylog}(T)$ gradient evaluations per epoch. All previous results imply a bound on the number of gradient or function evaluations which is at least linear in $T$. Motivated by real-world applications, we assume that functions are smooth, their associated distributions have a bounded second moment, and their minimizer drifts in a bounded manner, but do not assume they are strongly convex. In particular, our assumptions hold for online Bayesian logistic regression, when the data satisfy natural regularity properties, giving a sampling algorithm with updates that are poly-logarithmic in $T$. In simulations, our algorithm achieves accuracy comparable to an algorithm specialized to logistic regression. Key to our algorithm is a novel stochastic gradient Langevin dynamics Markov chain with a carefully designed variance reduction step and constant batch size. Technically, lack of strong convexity is a significant barrier to analysis and, here, our main contribution is a martingale exit time argument that shows our Markov chain remains in a ball of radius roughly poly-logarithmic in $T$ for enough time to reach within $\varepsilon$ of $\pi_t$.


This paper proposes a paradigm for managing the dynamic aspects of organizational knowledge creating processes. Its central theme is that organizational knowledge is created through a continuous dialogue between tacit and explicit knowledge. The nature of this dialogue is examined and four patterns of interaction involving tacit and explicit knowledge are identified. It is argued that while new knowledge is developed by individuals, organizations play a critical role in articulating and amplifying that knowledge. A theoretical framework is developed which provides an analytical perspective on the constituent dimensions of knowledge creation. This framework is then applied in two operational models for facilitating the dynamic creation of appropriate organizational knowledge.


This paper examines how to effectively teach students who learn differently. Teaching method and learning style theory and research are relevant in addressing this issue because many such students are able to excel in certain areas but not in others. The paper uses the example of a student who excelled only in Bible education and art, explaining that such classes are Laught aifferently than ocher classes. Many teachers dc.Livei: information in ways that only some students understand easily, teaching to students who are more analytic than global learners. Students must then be analytic learners in order to effectively process information presented in this manner. Most students (particularly younger students) do not learn analytically. Society focuses on traditional teaching and evaluation methods. Standardized tests are biased against global processors. Current teaching and assessing methods are too narrow and rigid to cover most students' range of abilities, knowledge, and understanding. The concept of multiple intelligences is relevant to this issue, though few schools work to develop all intelligences in all students. The paper presents suggestions for effectively teaching and assessing global learners. It also describes how to teach students who have visual perceptual problems and who are sensitive to light. (SM) Reproductions supplied by EDRS are the best that can be made from the original document. PERMISSION TO REPRODUCE AND DISSEMINATE THIS MATERIAL HAS BEEN GRANTED BY


Shortly after completing THE DROWNED AND THE SAVED, Primo Levi committed suicide. The matter of his death was sudden, violent and unpremiditated, and there were some who argue that he killed himself because he was tormented by guilt - guilt that he had survived the horrors of Auschwitz while others, better than he, had gone to the wall. THE DROWNED AND THE SAVED is Levi's impassioned attempt to understand the 'rationale' behind the concentration camps, was completed shortly before his tragic death in 1987. THE DROWNED AND THE SAVED dispels the myth that Primo Levi forgave the Germans for what they did to his people. He didn't and couldn't forgive. He refused, however, to indulge in what he called 'the bestial vice of hatred' which is an entirely different matter. The voice that sounds in his writing is that of a reasonable man...it warns and reminds us that the unimaginable can happen again. A would-be tyrant is waiting in the wings, with 'beautiful words' on his lips. The book is constantly impressing on us the need to learn from the past, to make sense of the senseless' PAUL BAILEY


SMS language is regarded as a 'new' communication system (cf. T. Shortis 2007; D. Crystal 2009; M. Markus 2010) characterized by new relationships that native speakers establish between English spelling and pronunciation by using different respelling devices (cf. C. Thurlow 2003; P. Lopez Rua 2007; D. Crystal 2009). This paper is an attempt to contribute to this recent area of study by analysing the development of SMS language over the last 10 years. Recent findings suggest that even though SMS language might have emerged out of the need for speed and brevity (C. Thurlow 2003: 4) — every SMS has a limited amount of characters —, it seems to have evolved into a fashionable and stylish way of writing where shortened versions of the words are not always the aim of the respelling. For the purpose of a diachronic analysis a free online British SMS corpus available at netting-it.com containing 201 text messages compiled in 2000 has been used in comparison with my own data obtained in May 2010 by means of questionnaires carried out in a London secondary school. Thus, it was possible to analyse the differences in the use of SMS language during the last decade. The research proves that one of the most significant changes is the use of 'stylish talk', a new device which consists in lengthening words to emphasize accent, slang, and attitude. This contrasts with the general belief that words are merely shortened in SMS language. Moreover, the use of slang and ungrammatical expressions also seem to be frequent devices.


WorleyParsons has been awarded a USD 90m contract extension by BP Iraq NV, and its partners PetroChina and the State Oil Marketing Organisation (SOMO) of the Republic of Iraq, to continue providing Engineering, Procurement and Management services to boost production from the super-giant Rumaila oilfield in Southern Iraq. In November 2009, BP and its partners entered into a 20 year Technical Service Contract (TSC) with the South Oil Company of Iraq. Under the terms of the TSC, the BP led consortium is required to nearly triple output from the field to 2.85 million barrels of oil per day over the next 6 years. On completion of this work, Rumaila will become the world's second largest producing oil field, contributing approximately 10% of Middle East production, 7% of OPEC production and 3% of global production. The contract is being executed from WorleyParsons' offices in London, UAE and Iraq. Commenting, WorleyParsons' CEO Andrew Wood stated "We are pleased to be able to continue our involvement in the reconstruction and development of Iraq's oil and gas infrastructure. We understand the significance of the Rumaila development to the regeneration of the Iraqi economy, and we will work closely with the partners in the Rumaila development, BP, PetroChina and SOMO to create the maximum value over the life time of the field".


Recurrent Neural Networks (RNNs) continue to show outstanding performance in sequence modeling tasks. However, training RNNs on long sequences often face challenges like slow inference, vanishing gradients and difficulty in capturing long term dependencies. In backpropagation through time settings, these issues are tightly coupled with the large, sequential computational graph resulting from unfolding the RNN in time. We introduce the Skip RNN model which extends existing RNN models by learning to skip state updates and shortens the effective size of the computational graph. This model can also be encouraged to perform fewer state updates through a budget constraint. We evaluate the proposed model on various tasks and show how it can reduce the number of required RNN updates while preserving, and sometimes even improving, the performance of the baseline RNN models. Source code is publicly available at this https URL .


Owing to the significant change in the business environment, strategic alliance has become an increasingly popular way in response to the ever changing environments featured by shorter product life cycle and fiercer competition. Drawing on the resource-based view and institutional theory, this study aims to explore under what conditions a biotech start-up is able to deliver an effective signal to the investment community so as to yield a better IPO (Initial Public Offering) performance. In the sample of 283 alliances involving biotech firms with other identities of organizations, the results show that allying with different identities of partners, namely, pharmaceutical firms or prestigious academic institutions, significantly influences a young biotech firm's IPO performance. Furthermore, the study shows that the IPO performance of partner identity is subject to firm capabilities and market conditions. The study contributes to the strategy literature by shedding light on the endorsement effects of legitimate partners. JEL classification numbers: L14, M10, M19


Abstract Background: Various studies have associated inflammation with carcinogenesis. But still, the role of inflammatory markers in oral cancer has not been evaluated extensively. Most of the existing studies have been done on patients of varied sites, and their sample size is also scarce. In this study, we have evaluated the impact of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) on various clinicopathological factors and survival. Methodology: This was a retrospective analysis of prospectively collected data of 400 patients with oral squamous cell cancer. The pretreatment neutrophil and lymphocyte and platelet counts were recorded, and NLR and PLR were calculated for all patients. The NLR and PLR tertiles were correlated with the incidence of various clinicopathological factors and overall survival. Results: The median follow-up of the cohort was 36 months. The mean survival of the cohort was 41.7 months. PLR was associated with higher incidence of adverse clinicopathological factors. There was a trend of decreased overall survival with increasing NLR tertile. It was found to be significant only for the group which received adjuvant chemoradiotherapy (P 0.01). Patients with higher PLR values have been found to have a lower overall survival (P 0.006). Conclusion: NLR and PLR can be used to predict survival and outcomes in patients oral cavity cancer. PLR is a good predictor for adverse clinicopathological factors and survival. NLR can predict survival only in the subset of patients who have received chemotherapy.


ABSTRACTDegradation of toluene gas by ozone catalytic oxidation (OZCO) by using a MnO2-based ozone decomposition catalyst (ODC) was investigated to clarify the reactive site of ODC material with O3. An optimum structure for the ODC to remove O3 and toluene were proposed. For honeycomb ODC, toluene degradation by OZCO occurred only around the entrance of the honeycomb ODC, and we expected that a thinner ODC would increase the toluene degradation efficiency. A nonwoven fabric on which ODC was immobilized was developed to decompose O3 and volatile organic compounds simultaneously. The toluene degradation ratio and the mineralization of toluene to CO2 were determined to evaluate the performance of the fabric. Furthermore, the effects of relative humidity and O3 concentration on the decomposition and mineralization ratios were also investigated with or without 254 nm UV irradiation (UV254). The fabric decomposed and mineralized toluene to CO2, even at low O3 concentrations. Although high humidity reduced the degradation ratio of toluene, UV254 irradiation improved the recovery of the degradation ratio and increased the mineralization ratio.


A number of species of the dinoflagellate genus Alexandrium have been implicated in the
production of Paralytic Shellfish Poisoning (PSP) toxins but occasionally have also been
associated with the mortality of both cage-reared and wild raffish in such places as the Faroe
Islands (A. tamarense) (Mortensen 1985), Taiwan (A. minutum) (Su et al. 1993) and Egypt
(A. minutum) (Halim 1996).
In the present work exocellular toxicity was investigated in two species of Australian
dinoflagellates, A. minutum and Gymnodinium catenation. Both are known producers of
neurotoxic PSP toxins, but these toxins are only known to exist endocellularly. Investigations
took the form of animal based biological assays using the brine shrimp, Artemia sauna, and
juvenile greenback flounder, Rhombosolea taparina, which were exposed to whole cell and
cell-free cultures of the algae. Bioassays determined the time to mortality for both species,
while pathological changes in major tissues and changes in physiochemical characteristics of
the blood were characterised only in the flounder.
Even though Artemia did not feed on toxic dinoflagellate cells of G. catenatum and A.
minutum, cultures of these two species were found to kill Artemia within 24 hours.
However, only A. minutum culture-filtrate was toxic to Artemia whereas G. catenatum
culture-filtrate was not. Likewise, culture-filtrate of unialgal G. catenation cultures was found
to be non-toxic to flounder with no pathological changes in gills or other tissues observed. This
disproves the suspected involvement of G. catenation as the cause of clubbing necrosis gill
syndrome (Clark et al. 1997) documented in farmed Atlantic salmon in Tasmania. In contrast,
the culture-filtrate of unialgal A. minutum cultures was found to be highly toxic to flounder.
Artemia and flounder mortality occurred within 24h of exposure to full strength A. minutum
culture-filtrate. Flounder exhibited mild to severe histopathological gill changes including:
swelling, degeneration and sloughing of the respiratory epithelium. The primary lamellar
epithelial cells were so swollen in some areas that they displaced the respiratory epithelial cells
into the interlaminar region. Also apparent were varying degrees of swelling, vacuolation,
degeneration and cytoplasmic shrinkage of the gill chloride cells and hypertrophic or discharged
mucocytes. Also common were antemortem blood clots in the heart ventricular tissue. Changes
in blood physiochemical characteristics of flounder were also found with increases in blood potassium inducing a state of hyperkalemia. Hyperkalemia affects the contractile functioning of
the heart, causing bradycardia and atrial standstill and can lead to cardiac arrest. Increases in
gill-associated succinic dehydrogenase activity were observed but only when flounder were
exposed to 60% A. minutum culture-filtrate mixed with 40% sterile seawater. No similar effect
was observed in Artemia or flounder from exposure to seawater containing purified
gonyautoxins (GTX) 1-4 in concentrations equivalent to the normal endocellular levels.
Activity from the exocellular medium of A. minutum similar to that exhibited by Neurotoxic
Shellfish Poisoning (NSP) toxins was revealed by neuroblastoma tissue culture assays
(Manger et al. 1993), but neuroreceptor binding assays (Van Dolah et al. 1994) on the same
material failed to detect brevetoxins. Lipid soluble A. minutum extracts also failed to show
conclusive evidence for cytotcodcity to erythrocytes or gill tissues or toxicity to Artemia. This
would discount the involvement of the fast acting spirolides (reported from A. ostenfeldii),
which are lipophilic (Cembella et al. 1999).
Endo/exotoxicity of A. minutum was followed over the growth cycle of the dinoflagellate in
batch culture. Total Sodium Channel Blocking (SCB) toxin concentrations (STX equivalents)
and profiles of individual GTX 1-4 components (endocellular only), as well as toxicity of the
culture-filtrate to Artemia were examined. SCB activity was monitored by neuroreceptor
binding assay. Peaks in toxicity of the exocellular medium appeared concurrent with peaks in
the endocellular toxicity of GTXs (both occurring in early to late lag phase and declining as
time progressed). The SCB toxicity of the medium was found to be three orders of magnitude
higher (3.7-10.2 pg STX equivalents cell-1 ) than the endocellular SCB toxicity (169-610 fg
STX equiv. cell-1 ). This is one of the first reports conclusively demonstrating SCB toxicity in
the exocellular medium of a dinoflagellate
Endocellularly, the gonyautoxins GTX2and GTX3were dominant early in culture growth (36-
64 mole%, epimeric total on day 48) but as time progressed GTX 1and GTX4became
increasingly important (58-93 mole %, epimeric total on day 182). Antibiotic treatment of
dinoflagellate cultures reduced bacterial levels by up to 93% but this did not appear to affect
SCB toxicity, although it did decrease toxicity of the exocellular medium to Artemia, which
was highest later in culture growth. Toxicity of the A. minutum culture-filtrate towards
Artemia did not appear to be correlated with exocellular or endocellular total SCB toxicity nor
was it correlated with any individual toxic GTX fraction. It is concluded that, in addition to a
Sodium Channel Blocking agent, A. minutum is producing a cytotoxic ichthyotoxin that is not
a PSP toxin. This exotoxic principle is heat labile (reduced toxicity to Artemia above 80°C),
but is not a gonyautoxin or brevetoxin.
In fish A. minutum culture medium produces severe pathological gill lesions which resemble
some of those caused by the raphidophyte Chattonella marina (Endo et a/. 1985) which is
also associated with the NSP syndrome. Although damage to fish gills upon exposure to C.
marina is thought to be due to the production of highly reactive oxygen radicals (Tanaka et al.
1992) this was ruled out as the cause of his. topathology in this study as oxygen radicals are
short lived and appear to only occur in photosynthetically active cultures. The toxic principle(s)
of A. minutum remained active in the culture-filtrate even after the cells were removed and
stored frozen, in the dark for several weeks.
The present work on novel ichthyotoxins in A. minutum culture medium adds to preliminary
reports of such activity by both this species (Bagoien etal. 1996) as well as A. tamarense
(Hansen 1989, Ogata and Kodama 1986), suggesting that this phenomenon may be more
widespread.


This study aimed to evaluate the breeding value of Ongole bulls for first lactation milk yield and to rank them for their future use in nominated mating for production of qualiTy male calves. The first lactation records of 418 cows maintained at Livestock Research Station, Lam Farm, Guntur (Andhra Pradesh); Government Cattle Breeding Farm, Chadalwada (Andhra Pradesh); Government Livestock Farm, Chintaldevi (Andhra Pradesh) and Livestock Research Station, Mahanandi (Andhra Pradesh) that were daughters of 23 bulls and calved during 13 years from 1991 to 2003 were used in analysis. First lactation milk yield in Gngole cows averaged 539.01±21.10 kg. The effect of farm and period of calving was significant on this trait. The breeding value of different bulls varied from 485.84 to 565.69 kg in first set, from 518.49 to 553.94 kg in second set and from 525.12 to 568.42 kg in third set. The highest breeding value, was obscrved for sire No. L168 (set 3) followed by sire No. L29 (set I) and sire No. LIO (set 1). Their superiority over the herd average ranged between 18.71 and 29.41 kg (3.47 to 5.45%). The frozen semen of these top ranked bulls has been recommended for use on elite cows to produce young male calves for inducting in the new set (5).


Double-negative periphrastic litotes have been for nearly three centuries the usual way to express necessitive predicates in Japanese and Korean. These constructions do not, however, go back to the earliest stages of these languages and should not be invoked as evidence of a possible common origin. But Korean also has a double-affirmative periphrastic necessitive construction. Premodern Japanese has no overt counterpart to it, but it does have an auxiliary adjective that expresses necessity. I argue that this auxiliary was a grammaticalization of a periphrastic analogous in form and meaning to the Korean double-affirmative necessitive, and should be considered as evidence of a common origin. Looking at sampling of Transeurasian languages other than Korean and Japanese, it seems that double-affirmative necessitives may have been an innovation of a branch of Proto-Tungusic that later split into Proto-Korean-Japanese and the predecessor of Manchu.


Pulmonary arterial hypertension (PAH) is commonly associated with chronic hypoxemia in disorders such as chronic obstructive pulmonary disease (COPD). Prostacyclin analogs are widely used in the management of PAH patients; however, clinical efficacy and long-term tolerability of some prostacyclin analogs may be compromised by concomitant activation of the E-prostanoid 3 (EP3) receptor. Here, we found that EP3 expression is upregulated in pulmonary arterial smooth muscle cells (PASMCs) and human distal pulmonary arteries (PAs) in response to hypoxia. Either pharmacological inhibition of EP3 or Ep3 deletion attenuated both hypoxia and monocrotaline-induced pulmonary hypertension and restrained extracellular matrix accumulation in PAs in rodent models. In a murine PAH model, Ep3 deletion in SMCs, but not endothelial cells, retarded PA medial thickness. Knockdown of EP3α and EP3β, but not EP3γ, isoforms diminished hypoxia-induced TGF-β1 activation. Expression of either EP3α or EP3β in EP3-deficient PASMCs restored TGF-β1 activation in response to hypoxia. EP3α/β activation in PASMCs increased RhoA-dependent membrane type 1 extracellular matrix metalloproteinase (MMP) translocation to the cell surface, subsequently activating pro-MMP-2 and promoting TGF-β1 signaling. Activation or disruption of EP3 did not influence PASMC proliferation. Together, our results indicate that EP3 activation facilitates hypoxia-induced vascular remodeling and pulmonary hypertension in mice and suggest EP3 inhibition as a potential therapeutic strategy for pulmonary hypertension.


In this paper, we introduce Farfalle , a new permutation-based construction for building a pseudorandom function (PRF). The PRF takes as input a key and a sequence of arbitrary-length data strings, and returns an arbitrary-length output. It has a compression layer and an expansion layer , each involving the parallel application of a permutation. The construction also makes use of LFSR-like rolling functions for generating input and output masks and for updating the inner state during expansion. On top of the inherent parallelism, Farfalle instances can be very efficient because the construction imposes less requirements on the underlying primitive than, e.g., the duplex construction or typical block cipher modes. Farfalle has an incremental property: compression of common prefixes of inputs can be factored out. Thanks to its input-output characteristics, Farfalle is really versatile. We specify simple modes on top of it for authentication, encryption and authenticated encryption, as well as a wide block cipher mode. As a showcase, we present Kravatte, a very efficient instance of Farfalle based on Keccak- p [1600, n r ] permutations and formulate concrete security claims against classical and quantum adversaries. The permutations in the compression and expansion layers of Kravatte have only 6 rounds apiece and the rolling functions are lightweight. We provide a rationale for our choices and report on software performance.


A search for massive resonances decaying to a Z boson and a photon is performed in events with a hadronically decaying Z boson candidate, separately in light-quark and b quark decay modes, identified using jet substructure and advanced b tagging techniques. Results are based on samples of proton-proton collisions collected with the CMS detector at the LHC at center-of-mass energies of 8 and 13 TeV, corresponding to integrated luminosities of 19.7 and 2.7 inverse femtobarns, respectively. The results of the search are combined with those of a similar search in the leptonic decay modes of the Z boson, based on the same data sets. Spin-0 resonances with various widths and with masses in a range between 0.2 and 3.0 TeV are considered. No significant excess is observed either in the individual analyses or the combination. The results are presented in terms of upper limits on the production cross section of such resonances and constitute the most stringent limits to date for a wide range of masses.