Society is demanding larger and more complex information systems to support increasingly complex and critical organisational work. During or after the deployment of these systems it is typical for problematic socio-technical issues to arise. Whilst troubleshooting socio-technical issues in small-to-medium scale situations may be achievable using approaches such as rapid ethnography combined with a theoretical framework such as distributed cognition or activity theory; troubleshooting enterprise scale situations is an open research question because of the overwhelming number of socio-technical elements and interactions involved. Techniques and tools for complex network analysis enable the analysis of systems comprising large numbers of nodes. These tools are becoming increasingly accessible to non-computer scientists and mathematicians and so have been used to analyse a diverse variety of large-scale systems from social networks through to metabolic pathways in living organisms. We believe there is scope to use similar techniques to facilitate the analysis of problematic enterprise scale socio-technical systems. This paper demonstrates, via means of a case study, proof-of-concept tools for large-scale network analysis and visualisation that may provide a promising avenue for identifying problematic elements and interactions amongst an overwhelming number of socio- technical elements. We demonstrate the potential of this approach by showing that: i) a problematic situation may be represented as a directed graph such that the elements in the situation are represented as nodes, and interactions between nodes as edges; ii) that eigenvector centrality may be used to rank the importance of elements in a situation and that highly ranked elements match those identified as important by a human analyst; iii) the 'complexity' of a situation, or a part of a situation, may be characterised using a feedback degree score which provides an indication of the extent elements are highly interconnected and involved in feedback loops. T hese findings indicate that computers may be used to aid the analysis of problematic large-scale complex socio-technical situations by highlighting elements, or groups of interacting elements, that are important to the overall outcome of a problematic situation.


A computational method for predicting unsteady viscous flow through two-dimensional cascades accurately and efficiently is presented. The method is intended to predict the onset of the aeroelastic phenomenon of stall flutter. In stall flutter, viscous effects significantly impact the aeroelastic stability of a cascade. In the present effort, the unsteady flow is modeled using a time-linearized Navier-Stokes analysis. Thus, the unsteady flow field is decomposed into a nonlinear spatially varying mean flow plus a small-perturbation harmonically varying unsteady flow. The resulting equations that govern the perturbation flow are linear, variable coefficient partial differential equations. These equations are discretized on a deforming, multiblock, computational mesh and solved using a finite-volume Lax-Wendroff integration scheme. Numerical modeling issues relevant to the development of the unsteady aerodynamic analysis, including turbulence modeling, are discussed. Results from the present method are compared to experimental stall flutter data, and to a nonlinear time-domain Navier-Stokes analysis. The results presented demonstrate the ability of the present time-linearized analysis to model accurately the unsteady aerodynamics associated with turbomachinery stall flutter.


Sovereign Wealth Funds (SWFs) represent a new form of investment organizational structure and have grown to over $5.7 trillion assets under management by February 2016, making them a financial force potentially worth reckoning with in international financial markets. This article starts with a brief introduction of the 35 funds that meet our definition of SWFs, then discusses their evolution from stabilization funds to SWFs and illustrates the differences and similarities between the various types of funds. The most salient and controversial feature of SWFs is that they are state-owned; we survey the existing literature on state ownership and discuss what this predicts about the efficiency and beneficence of government control of SWF assets. We discuss the documented importance of SWF funding sources (oil sales revenues versus excess reserves from export earnings) and survey the normative literature describing how SWFs should allocate funds. We then summarize the empirical literature studying how SWFs actually do allocate funds across asset classes, geographically, and across industries. We document that most SWF equity investments in publicly traded firms involve cross-border purchases of sizeable minority stakes (median around 20%) in target firms. However, the most recent data shows a "shift to domestic investment" pattern and also an industry preference change from the financial to the real estate sector. Next, we assess empirical studies examining the impact of SWF stock investments on target firm financial and operating performance, and find universal support for a positive announcement period stock price increase of 1-3%. This, however, is significantly lower than the 5% abnormal return documented for stock purchases by comparable privately owned financial investors in recent studies, indicating a "sovereign wealth fund discount." Finally, we point out the unresolved issues and possible extensions in SWF research, and assess how the massive decline in oil export revenues by major SWF sponsor nations such as Abu Dhabi, Russia, Kuwait, and Norway is likely to impact SWF investment levels in coming years.


Pinky's family is getting a pet! The problem is, by a three to one vote, they've decided to get a cat, and Pinky wants a dog. And when they get a kitten, Pinky's sister, Amanda, says that Patches is "hers." Why should Pinky care? He didn't want a cat in the first place. But Patches may have her own ideas about whose cat she is.


Recent theoretical literature in social policy argued that climate change posed a new risk to the states and called for transformation from a traditional welfare state to an 'eco' state. From a theoretical point of view, different welfare regimes may manage environmental/climate change risks in a similar way to social risks. However, not much has been done to explore the issue empirically. To this end, this paper aims to investigate public attitudes towards environmental and traditional welfare policies given that environmental change is a new social risk the welfare states have to address. Do individuals that care for one area also care for the other? That is, do the preferences in these two policy spheres complement or substitute one another? We test these hypotheses both at the individualand country-level, using data from 14 countries included in all three waves (1993, 2000, and 2010) of the environmental module in the International Social Survey Programme. Specifically, we investigate the relationship between attitudes towards income redistribution (indicator of support for welfare policy) and willingness to pay for environmental protection (indicator of support for environmental policy). Our findings suggest that attitudes in the two areas are substitutes in the total sample, but that the relationship is very small and only statistically significant in some specifications. When we explore country differentials, we observe clear heterogeneity in the relationship, which can be explained by differences in political and historical contexts across countries. Corresponding author: Raya Muttarak, World Population Program, International Institute for Applied Systems Analysis (IIASA), Schlossplatz 1, A-2361 Laxenburg, Austria. Email: firstname.lastname@example.com Environment and Planning C: Politics and


We present a simulation model of the flow of tourists between 207 countries, used to study the impact of climate change on international tourism. The model almost perfectly reproduces the calibration year 1995, and performs well in reproducing the observations for 1980, 1985 and 1990. The model is used to generate scenarios of international tourist departures and arrivals for the period 2000-2075, with particular emphasis on climate change; we report variations on a single baseline scenario (A1B). The growth rate of international tourism is projected to increase over the coming decades, but may slow down later in the century, as demand for travel saturates. Emissions of carbon dioxide would increase quickly as well. With climate change, preferred destinations would shift to higher latitudes and altitudes. Tourists from temperate climates would spend more holidays in their home countries. As such tourists currently dominate the international tourism market, climate change would decrease worldwide tourism. Nevertheless, its effects are small compared to the baseline projections of population and economic growth.


Thrombomodulin (TM) is a surface protein on endothelial cells, and represents one of the most valuable regulatory factors in the anticoagulant system. In this paper, we demonstrate that retinoic acid (RA) causes an increase in TM antigen on human umbilical vein endothelial cells (HUVECs) in vitro. The effect of RA on the surface TM level of HUVECs was dose-dependent in the range from 0.01 to 10 microM-RA. Antigen levels began to increase 3 h after addition of 10 microM-RA, and plateaued at a maximum level of approx. 2.5 times that of the untreated control at 24 h. TM levels remained at a maximum for a further 12 h, and then gradually decreased. The effects of RA on cell surface TM activity and antigen levels were parallel in all experiments. TM expression was also increased by treatment with 10 microM-retinal or 10 microM-retinol for 24 h, though the increases were approx. 70% and 30% respectively of that produced by 10 microM-RA. Pretreatment of HUVECs with cycloheximide inhibited the effect of RA. When HUVECs were incubated with both 10 microM-RA and 5 mM-8-bromo cyclic AMP (or 1 mM-3-isobutyl-1-methylxanthine, a phosphodiesterase inhibitor), the increase in TM antigen was greater than that observed with either compound alone. Northern blot analysis showed that treatment of HUVECs with 8-bromo cyclic AMP, RA or RA plus 8-bromo cyclic AMP increased TM mRNA levels by 2.2-, 4.5- and 5.5-fold respectively compared with the untreated control. Furthermore, no significant difference in cellular cyclic AMP levels was observed between RA-treated and control cells. These results indicate that the expression of TM is not only controlled by the intracellular cyclic AMP level but is also affected by RA, and suggest that RA-induced up-regulation of TM on HUVECs is independent of cyclic AMP regulation.


The demand for safer and more efficient non-viral gene vectors has increased with the recent progress of genetic medicine. Appropriate nanocomplex assembly of DNA and gene carriers is critical for successful cellular entry and transfection. However, there is a lack of knowledge on this self-assembly process, let alone the controllability of monodisperse nanocomplexes. This paper describes a novel platform integrating nanobiophotonics (quantum dots-mediated FRET) and microfluidic technology to determine binding kinetics that govern the structural and chemical properties of DNA nanocomplexes. We anticipate that this method will elucidate mechanistic and kinetic insights into the self-assembly process of nanocomplexes which may facilitate the rational design of more efficient gene carriers. In addition, a microfluidic platform offers many advantages, including small volume, fast response to external stimulations, continuous monitoring and real-time control of reaction environments, which may be potentially used to generate more monodisperse complexes.


Investment is planting of assets carried out by company or individual. One of investment model is crowdfunding where collecting funds from large community so that significant funds are collected. Crowdfunding is managed by mobile application platform so that make easily accessed. To make customer investment, it is necessary through an investment provider. One of the important things of investment provider is service quality. Sometimes investment provider companies have problem in knowing the factor that can increase customer satisfication. This can make the company wrong in providing services needed by its customer.To find out the level of investor satisfication an analyse of factor that influence satisfication can be done. Factor of service quality can be used in the analyse. In service quality there are several factor namely tangibels, reliability, responsiveness, assurance and emphaty. In analysing used SPSS software to see the influence of these factors. After conducting research shows that service quality can affect customer satisfication, especially in the variables of reliability, responsiveness and tangibels that have significant influence. For the assurance and emphaty variables, they have an influence but not significantly. Therefore crowdfunding investment platform can implement aspects of service quality to influence their investor satisfication.


The study was conducted in a montane grassland of Kokosa District, West Arsi Zone of Oromia Region, southern Ethiopia. The objective of the study was to investigate the relationships between aboveground plant biomass and species richness in three farming systems and four grazing management systems. A total of 180 quadrats (each 1 m x 1 m) were sampled in the three farming systems (dominant livestock- enset , enset -livestock and enset -livestock-cereal) and four grazing management systems (communal, enclosure, stream bank and benchmark). All the farming system and grazing management have different management practices. Plant species composition and aboveground plant biomass at different sites were quantified. Altogether 50 plant species (34 grasses, 4 legumes, 3 sedges and 9 forbs) were recorded in the montane grassland of Kokosa District. Even though the majority of the plant species share the different farming systems and grazing management practices, the highest number of species (39) was recorded in the enset -livestock farming system, whereas the lowest (33) species were recorded in the enset- livestock-cereal farming system when all the grazing management and farming systems were combined. Significantly, the highest species richness (4.9 species m -2 ) was recorded in the enclosure grazing management site whereas the lowest (3.4 species m -2 ) was recorded in the benchmark grazing site when all grazing sites and farming systems were combined. The relationship between species richness and biomass was detected in the montane grassland. There was significant difference (P ≤ 0.05) in species richness for a combination analysis of farming system by grazing management system of the montane grassland. The highest biomass was recorded in the benchmark grazing management sites while the lowest was recorded in the communal grazing sites. On the contrary, maximum species richness was found in the enclosure grazing management sites which had intermediate biomass yield and the lowest species richness was recorded in the benchmark grazing areas with the maximum biomass records. Thus, species richness was observed first to ascend along with biomass increment up to 1932 kg ha -1 and then declined at constant increase of biomass. An increase in biomass in the benchmark grazing sites was not accompanied by an increase in species richness suggesting the dominance of few species in these sites. The rationale behind this might be due to the competitive exclusion of the less competent species from the community at peak biomass production. Keywords: Biomass; Farming System; Grazing Management; Montane Grassland; Species Richness


Modern power electronics develop very rapidly. The main direction for development nowadays is increasing power density. This can be achieved by utilizing higher switching frequencies. The last generation of SiC and GaN semiconductors can reach switching frequencies up to several MHz. At the same time the number of power electronics devices connected to the power grid has grown significantly during past decades and continues to increase. These two factors result in the high level of power grid pollution with electromagnetic interferences. In order to minimize the emission level, passive electromagnetic interference (EMI) filters are employed.
 Within the frame of this thesis, issues related to design and improvement of EMI filters for three-phase power electronic converters are comprehensively studied. Detailed analyses of magnetic materials, filter components, mutual couplings, enhancement methods and filter topologies are presented. Insertion loss of EMI filters is analysed within a system under idealised conditions 50 Ohm reference impedance). Moreover the impact of the reference impedance used for EMI filter characterisation on insertion loss is investigated based on mathematical models.
 Behavioural models of EMI filters with different complexity are developed. Diverse simulation approaches are used for profound understanding of the physical processes inherent in EMI filters. Exactness of the behavioural models is proven by measurements of built prototypes. The main insertion loss degradation mechanisms are derived from the developed models. The advantages and disadvantages of models based upon the network theory, S-functions and differential equations with the help of electronic design automation tools are shown.
 Existing filter improvement methods are systematized and complemented. Novel improvement possibilities for conventional filters including parasitics compensation methods and mutual coupling minimization are developed. Different combinations of improvement methodologies are applied to reference EMI filters and tested. Multistage filters with enhanced topologies are proposed. Critical comparison of conventional and proposed filter topologies considering power density and costs is carried out. Obtained results demonstrate considerable advantages of enhanced EMI filter topologies over conventional ones.
 Three phase power electronics systems are examined from the perspective of electromagnetic compatibility. Analysis of common and differential currents' contribution into the spectrum of a conventional drive system is carried out. EMI filters are tested together with different types of power electronic converters. Effects caused by variation of converter parameters on the emitted spectrum of disturbances are assessed from the EMI filter design point if view. It is determined that essentially all investigated parameters of a power electronics converter and a drive system except DC voltage fluctuation have feasible impact on the EMI spectrum. Thus EMC behaviour of the system can be adjusted by variation of these parameters. Semiconductor speed, motor stray capacitance and concept of protective earthing are determined as the most relevant system parameters influencing EMI filter design.


Despite improvements in surgical techniques and adjuvant chemotherapy, the overall mortality rates in pancreatic cancer have generally remained relatively unchanged and the 5-year survival rate is actually below 2%. This paper will address the importance of achieving an early diagnosis and identifying markers for prognosis and response to therapy such as genes, proteins, microRNAs or epigenetic modifications. However, there are still major hurdles when translating investigational biomarkers into routine clinical practice. Furthermore, novel ways of secondary screening in high-risk individuals, such as artificial neural networks and modern imaging, will be discussed. Drug resistance is ubiquitous in pancreatic cancer. Several mechanisms of drug resistance have already been revealed, including human equilibrative nucleoside transporter-1 status, multidrug resistance proteins, aberrant signaling pathways, microRNAs, stromal influence, epithelial-mesenchymal transition-type cells and recently the presence of cancer stem cells/cancer-initiating cells. These factors must be considered when developing more customized types of intervention ("personalized medicine"). In the future, multifunctional nanoparticles that combine a specific targeting agent, an imaging probe, a cell-penetrating agent, a biocompatible polymer and an anti-cancer drug may become valuable for the management of patients with pancreatic cancer.


This study has increased knowledge about relationships between pathogen indicators, source identifiers and pathogens to support Quantitative Microbial Risk Assessment (QMRA) efforts and the implementation of revised recreational water quality criteria. Data gaps pertaining to waterborne pathogens and indicators in fecally-impacted discharges to recreational waters were identified and filled by targeted monitoring campaigns in three geographic regions. Study design involved simultaneous detection of pathogens in water samples using a combination of genetic, culture- and microscopy-based methodologies for Salmonella, Campylobacter jejuni, Vibrio cholerae, Cryptosporidium, Giardia, Toxoplasma gondii, adenoviruses, enteroviruses, noroviruses, rotaviruses, Bacteroidales, Enterococcus, and Escherichia coli.

The project team worked closely with experts and stakeholder groups in order to advance the understanding and applicability of QMRA for risk management purposes. QMRA analyses revealed Norovirus as the most dominant health risk followed by rotavirus. Norovirus and Enterococcus both had significant correlations with a number of pathogens in discharges.

Using qPCR data on the fecal source identifier Bacteroidales a new model can predict the true amount of human fecal contamination in a water sample by relating a human-associated genetic marker to a universal assay for fecal sources. The model output can then be used to implement and evaluate management options intended to restore microbial water quality.

This title belongs to WERF Research Report Series .

ISBN: 9781843395430 (eBook)


In view of the diversity that exists among consumers, this study argues the importance
of focusing on just one sub-group of consumers. Therefore, the study aims to explore
the attitudes, motivations, and purchase behaviour of low-income women consumers
to 'low-involvement' products. More specifically, the adopted methodology
comprises of a focus group discussion followed by thirty semi-structured interviews.
Findings suggest that low-income women consumers engage in habitual purchasing
and are not loyal to brands of grocery products. However, they often buy stores' own
value-range brands as they believe that these products are similar to manufacturers'
brands. They do not perceive price to be an indication of quality, rather they attribute
basic differences between the stores' own value-range and manufacturers' brands as
'expensive packaging' and the popularity of the brand name. Value for money was
revealed as a key motivation underlying their purchasing of grocery products.
Consequently, they are very sensitive to sales promotions and actively engage in
making comparisons between the promotions in different stores within their locality.
The implications of the study are twofold. Firstly, this research challenges the
common assumptions within the consumer behaviour literature that all grocery
products are low-involvement. Hence, generalisation in consumer behaviour without
due reference to the contextual factors identified among low-income women
consumers provides a limited understanding of their decision making and purchase
behaviour. Secondly, from a marketing perspective, the study supports the importance
of segmentation/targeting with regard to the design of appropriate sales promotion
techniques for targeting low-income consumers.


Introduction With the unprecedented and unbeatable financial investment and almost perfect organizing and arrangement, the 2008 Beijing Olympic Games is generally considered one of the most successful and magnificent Games so far in the history of modern Olympic Games, which deserved the praise International Olympic Committee (IOC) president Rogge made at the Games' closing ceremony, a truly exceptional Games. It took the Chinese Olympic Committee (COC) and the Chinese government twenty-nine years from a just-officially-recognized member of the international Olympic family to a host of the most amazing Olympic Games for the world. The IOC re-accepted the COC as an formal member in November 1979 after a twenty-one-year isolation since the COC withdrew from the IOC and all International Sport Federations (ISFs) in 1958 due to the "two Chinas" issue. This issue erupted between the People's republic of China (PRC) and Taiwan; the Chinese Communist Party (CCP) had established the PRC, while the Chinese Nationalists Party (KMT) retreated to Taiwan in 1949. Despite the COC was formally recognized by the IOC in 1979, it took the COC five years to make its significant debut at the 1984 Los Angeles Games. In 1980, responding the decision of the United States, the PRC government boycotted the Moscow Olympic Games. Unlike most of the countries from the communism camp that boycotted the 1984 Los Angeles Olympic Games, as a communist country, the PRC government sent athletes there and achieved excellent performances, thereby establishing a solid foundation upon which to build their future progress in the Olympic Games. The question why the PRC government chose the 1984 Los Angeles Olympic Games instead of the 1980 Moscow Olympic Games as the debut of the Chinese athletes on the global sport stage, which has not been responded to academically, and which few studies have paid attention to, was the main focus of this study. Around this research question, to address the void, this study investigated the historical facts regarding the development of the national sport and sport policies in China between 1980 and 1984, a critical transition in the history of Chinese sport. The PRC's reinstatement in the IOC took place during the period of the boycotts of the Moscow and Los Angeles Olympic Games happened, which were seen as a direct confrontation between the two superpowers. To appropriately cope with the boycotts, the Chinese government considered not only the factors in the sport domain, but also the factors in the international politics domain, especially, its relations with the two superpowers. Therefore, it is necessary to establish a basic understanding of Sino-Soviet Relations and Sino-US Relations from the 1950s to 1970s. When the PRC was established in October 1949, Sino-Soviet Relations were cooperative and mutually supportive. The two countries signed the Treaty of Friendship, Alliance and Mutual Assistance in February 1950. During the following decade, the Soviet Union gave the PRC all possible military, technical, and financial help. According to Sheng, the Soviet Union believed if socialism was victorious in China and other communism countries, then victory of socialism throughout the world would be virtually secured. (1) Both Russian and Chinese scholars accept that the Treaty was highly important for the PRC to reconstruct the country at the time. (2) The friendly relationship between the two countries did not immediately change following the death of Stalin and Nikita Khrushchev becoming the successor in 1953. Despite Khrushchev's revision of the national policies, Sino-Soviet Relations was maintained between 1953 and 1958. (3) However, the argument and the ideological differences had already appeared between the two countries. (4) In 1958, the Sino-Soviet disagreement on the "Great Leap Forward (GLF)" initiated by Mao Zedong increased the misunderstanding. (5) As a result, Sino-Soviet Relations finally shifted from mutual cooperation to hostile confrontation at the beginning of the 1960s. …


For the first time, sediment trap samples from several depths in the deep sea were analyzed to estimate both the types and amounts of mineral contributed by dinoflagellates to the deep sea sediment flux. Thecal remains of dinoflagellate motile stages were almost entirely restricted to the upper few hundred meters of the water column, supporting the generally accepted explanation of their absence in the fossil reord (I.e., theca are composed of cellulosic material which is destroyed before they may be incorporated into bottom sediments). The main contribution to the sediment flux is composed of resting cysts routinely produced in the life cycles of just a few of the more obscure oceanic dinoflagellates, probably species of Scrippsiella or Ensiculifera. The cyst assemblage sedimenting out from plankton at present is overwhelmingly dominated by a few small calcareous types (up to several thousands/m2/day). If not dissolved, these may accumulate in paleontologically significant amounts in bottom sediments to give the most representative fossil record oj' oceanic dinoflagellates. "Oceanic assemblages" oj' organic-walled cysts from Recent deep-sea sediments previously described by palynologists probably represent long distance transport from more coastal regions rather than oceanic dinoflagellate production.


Translation and Globalization is essential reading for anyone with an interest in translation, or a concern for the future of our world's languages and cultures. This is a critical exploration of the ways in which radical changes to the world economy have affected contemporary translation. The Internet, new technology, machine translation and the emergence of a worldwide, multi-million dollar translation industry have dramatically altered the complex relationship between translators, language and power. In this book, Michael Cronin looks at the changing geography of translation practice and offers new ways of understanding the role of the translator in globalized societies and economies. Drawing on examples and case-studies from Europe, Africa, Asia, and the Americas, the author argues that translation is central to debates about language and cultural identity, and shows why consideration of the role of translation and translators is a necessary part of safeguarding and promoting linguistic and cultural diversity.


Experience of teaching in France in the late 1950s led to an awareness of excellent methods and resources for religious education. This in turn led to a study of the French catechetical renewal movement. While it became evident that the main movement was led by Fr Joseph Colomb in the years immediately following the Second World War, it was soon apparent that the roots extended much further back in time. The present work is concerned with tracing the roots of the early catechetical renewal, set against the background of the early twentieth century. The influence on it of movements such as Modernism, and of the new educational ideas, are considered as well as others from abroad such as the Munich Movement. The effect of the call for a more gospel based approach in the teaching of religion by Bishop Landrieux of Dijon in 1922 and a moving away from the Catechism is discussed. Among the key figures who emerged in the years between the two world wars were Mme Marie Fargues and Mlle Francoise Derkenne, also Fr Andre Boyer and Fr Charles Quinet. Their creative activity was particularly intense in the 1930s. Their influence, traced in many instances through unpublished correspondence, is shown to be considerable, not only in France but in the wider international sphere. In particular, there is evidence that their change of approach to the concept of religious education as opposed to that of religious instruction came about sooner in France than elsewhere. It is also suggested that the remarkable tenacity of some of the pioneers in the face of considerable opposition may have helped to bring about the changed attitude to the laity, particularly to women, in certain branches of the Christian Church.


Based on Ullman's (2004) hypothesis that declarative memory impairment will contribute to language impairment, this thesis presents two experiments that test familiarity and recollection in children with Autism Spectrum Disorder (ASD) and Intellectual Disability (ID). Four experimental groups comprised children and adolescents with ASD with language impairment (ALI); ASD without language impairment (ALN), intellectually disabled children without ASD (ID) and typically developing children (TD). Children were tested on two forced choice recognition tests of familiarity and recollection and a shape recognition and cued action-recall test. The relation between familiarity and conceptual semantic knowledge was investigated whilst controlling for visuo-perceptual abilities and fluid intelligence. Findings confirmed an association between familiarity and conceptual semantic knowledge in the ASD population as well as the use of visuo-perceptual skills to enhance familiarity. The broader role of declarative memory in language is addressed in ASD. Implications for future methods of testing in ASD populations are considered, as are implications of declarative memory anomalies in both ASD and ID populations in educational settings.


Evaluating the hypothesis of New Zealand's total submersion during the Oligocene requires the strictest tests, including sound phylogenetic data and dating of phylogenies. Although New Zealand has been traditionally considered to host ancient biota that originated by vicariance after it separated from Australia ~80 Mya, the ancient origins of its biota have been recently questioned, with some authors even suggesting that all current land organisms had to arrive to the islands after it re-emerged from the ocean 22 million years ago. Here we examine examples of short-range endemic soil-dwelling invertebrates and find compelling evidence that at least some of them are the result of old lineages that diversified in New Zealand before the hypothesised submersion event 22 million year ago. We conclude that New Zealand indeed has old lineages as well as recently diversified lineages and compare this situation with that of other more stable areas of the Neotropics.


A number of factors have been identified as generally reliable predictors of individual
differences in responses to acute pain (e. g. sex, personality traits and cultural affiliation).
These factors constitute relatively stable, long-term characteristics of an individual.
However, there is also significant within-individual variation in response to acute pain,
suggesting that factors other than individual characteristics also influence pain response.
It is known that affective-motivational state is a significant component of pain, and it has
been argued also that the process of automatic evaluation effects changes in affectivemotivational
state through the activity of limbic structures associated with the detection and
processing of emotionally valenced environmental information. This thesis proposes that
through this mechanism, qualities of the immediate environment can act as modifiers of
pain response.
A series of experiments were conducted to test for the effects of manipulation of social,
contextual and environmental features on responses to a mechanical pain stimulus. The
results show that manipulation of preparatory information and locus of perceived control
within the experimental dyad resulted in significant changes in response to the second of
two pain stimuli of identical intensity. Also, both the sex of the assessor and the presence
of a negatively valenced feature in the test environment were shown to influence pain
response significantly. These results are in line with evidence from research into
automaticity and automatic evaluation, and recent evidence concerning the roles of limbic
areas in emotional processing and pain.
The results provide further insight into the nature of acute pain, and suggest that individual
variation in pain response may be explained in terms of an integrated biopsychosocial
model, which includes what is known of the neural bases underlying the sensory and
affective-motivational components of pain (the pain matrix), but also acknowledges the
roles of socially acquired, long-term cognitive structures relating to individual traits, and
the influence of automatic evaluation. The results have significant implications for clinical
and research practices as they indicate that qualities of the environment may impact upon
clinical and experimental pain measurement. Moreover, they indicate that individuals can
be 'primed' for pain by qualities of their environment and as a result, may suffer
unnecessarily during acutely painful clinical procedures. However, awareness of these
principles may be useful in developing methods of reducing suffering in those situations.


Organizational learning has been identified as a pivotal aspect in contributing to the competitive advantage of organizations (e.g. Argote & Ingram, 2000). However, despite ambiguous results on their effectiveness, traditional programs continue to dominate organizational learning initiatives. In this context, Communities of Learning (CoL) are an innovative methodological tool to stimulate knowledge creation and diffusion among members of an organization's workforce. Previous research has shown that such (online) collaborative learning processes are significantly influenced by the hierarchical positions of individual participants within these communities (e.g. Romme, 1996). However, little is known about how exactly participants' hierarchical positions influence individual levels of activity and performance levels within CoLs. The present study provides empirical evidence on 27 CoLs of a global training program, analyzing user statistics from asynchronous discussion forums for 235 staff members. The results of our study not only indicate that participants' hierarchical position has a significant impact on their general level of activity, as well as their final grade. We are also able to reveal a group of "Stars" that lead their CoLs irrespective of their hierarchal position. Similarly, our findings suggest a certain duality among participants holding the lowest hierarchical positions. While the majority exhibits a "follower" mentality, a smaller subgroup appears to take on roles and behaviours usually assigned to team leaders. By considering these insights, managers of training programs can better anticipate participants' behaviour and device collaborative learning activities that foster a vibrant learning environment, contributing to higher levels of cognitive discourse and social interaction among participants.


Adsorbed natural gas (ANG) technique was used in this study to test the adsorption capacity of carbon materials fro methane gas storage. An adsorption system based on volumetric method was designed and fabricated for this purpose. The carbon materials used were Malaysian industrial activated carbon produced from palm kernel shell and coconut shells. These materials have not been thoroughly investigated for ANG applications. Also a new material which is a composite of CNTs and activated carbon (ACNT) produced in this work along with commercial CNTs were investigated as ANG storage media.
ACNT was produced using chemical vapour deposition (CVD) method using activated carbon as catalyst substrate. The presence of activated carbon, besides being substrate, served as auxiliary storage media. This method successfully produced CNTs with diameters ranged form 25 to 70 nm and lengths, mostly, of more than 10 μm. These long tubes could be a result of the long reaction time (3 hours), thus if shorter CNTs are required, shorter reaction times should be applied.
The adsorption storage experiments were run at pressures up to 50 bar and temperatures of 30, 40 and 50 °C. The adsorption capacity on mass basis (at 35 bar and 30 °C) ranged from as low as 1.48 mmol/g for com-CNT to 6.20 mmol/g for CSAC3. ACNT showed a relatively high adsorption capacity of 4.51 mmol/g. The results indicate that there is a general trend of increasing in adsorption capacity with increasing micropore volume. However, micropore size distribution (MPSD) must be taken into account in evaluating the adsorbents.
The adsorption capacity on volume basis (V/V) ranged from 51.57 for com-CNT to 106.46 for CSAC2. These values are still below the targeted 150 V/V. While some adsorbents showed the highest adsorption capacity on mass basis compared to others (CSAC3 versus CSAC2), yet their capacity on volume basis was lower as a result of their lower bulk density. This showed the importance of this parameter in ANG applications.
The methane delivered values were 7-25% lower than the volumetric methane storage capacity. The high retention of methane gas at atmospheric pressure by some adsorbents could be explained by their narrow MPSD. Accordingly, the narrow MPSD helps in increasing the adsorption capacity, yet, the very narrow MPSD will increase the amount of gas retained.Several single component isotherm models were used to fit the experimental adsorption isotherm data. All the adsorption isotherm models used showed a good fit to the experimental data. However, Langmuir isotherm model was chosen to be used in the dynamic model to restrict the already heavy computational load from being unrealistic.
The experimental data obtained from the storage and delivery tests were compared to those obtained from process simulation using a dynamic model. The simulation model was run using the measured equilibrium data as input parameters. A good agreement was observed between experimental and simulated results. Pressure and temperature histories were acceptably well predicted


Abstract. Global drylands encompassing hyper-arid, arid, semiarid, and dry subhumid areas cover about 41 percent of the earth's terrestrial surface and are home to more than a third of the world's population. By analyzing observations for 1948–2008 and climate model simulations for 1948–2100, we show that global drylands have expanded in the last sixty years and will continue to expand in the 21st~century. By the end of this century, the world's drylands (under a high greenhouse gas emission scenario) are projected to be 5.8 × 10 6 km 2 (or 10%) larger than in the 1961–1990 climatology. The major expansion of arid regions will occur over southwest North America, the northern fringe of Africa, southern Africa, and Australia, while major expansions of semiarid regions will occur over the north side of the Mediterranean, southern Africa, and North and South America. The global dryland expansions will increase the population affected by water scarcity and land degradations.


Doctors and Rules is a unique and immensely scholarly book. It draws on material which has informed our civilization, including many of the social sciences-history, sociology, and psychology, as well as law. The author accesses the current importance of the Hippocratic tradition within medicine, and puts forward various models of its practice. He seeks to expose the often inarticulated foundation of contemporary debates about the law, medicine, and health, and to question some common assumptions of the functionsand structures of social and legal order. The book challenges the idea that legal rules should be respected merely because they exist and because they play a part in centralizing the organization of society. It rejects the notion that the courts always, or even often, offer useful mechanisms for defining and settling disputes. On the contrary, the author sees in their formalism many things which hinder the common cause of humanity. Only a skeptic trained in law but also deeply concerned by our fate and circumstances could have produced it. It also contributes both to the sociology of law and the sociology of medicine. Out of a reassertion of old ways, this book presents a new blueprint for future professional conduct. It is rich in questions and ideas for researchers, teachers, and professionals in the fields of law, medical sociology, and medicine and generally for those concerned with the place of professional conduct.


Virtualization technology enables Cloud providers to efficiently use their computing services and resources. Even if the benefits in terms of performance, maintenance, and cost are evident, however, virtualization has also been exploited by attackers to devise new ways to compromise a system. To address these problems, research security solutions have evolved considerably over the years to cope with new attacks and threat models. In this work, we review the protection strategies proposed in the literature and show how some of the solutions have been invalidated by new attacks, or threat models, that were previously not considered. The goal is to show the evolution of the threats, and of the related security and trust assumptions, in virtualized systems that have given rise to complex threat models and the corresponding sophistication of protection strategies to deal with such attacks. We also categorize threat models, security and trust assumptions, and attacks against a virtualized system at the different layers—in particular, hardware, virtualization, OS, and application.


At the end of the Pleistocene (25,000-15,000 BP), there is a shift to more arid conditions in the Negev and the Sinai corresponding to the Last Glacial Maximum. For the Nile Valley and the Levant, the lowering of the Mediterranean sea level, the expansion of the Sahara and the desiccation of some major eastern African lakes had important consequences on: (1) the general behaviour of the River Nile; (2) the landscape around the Nile Delta; and (3) sand dune mobilisation. Despite this shift to more arid conditions, there is abundant evidence for human occupation in the Egyptian Nile Valley and in the arid zone of the Southern Levant at this time. In addition, contacts between these two regions have sometimes been suggested, mainly by genetic studies, including early 'Back-to-Africa' dispersals.
This paper focuses on the analysis of six terminal Pleistocene (ca. 25,000-15,000 BP) lithic assemblages from the western Negev Desert dunes in Israel, attributed to the Early and Middle Epipalaeolithic. The analysis relies on the chaine operatoire approach combined with attribute analysis that enables quantification of typo-technological differences. Results of this analysis allows comparisons with assemblages from the Egyptian Nile Valley analysed in the same way previously. This comparative analysis is then used to discuss hypotheses of potential technical diffusions between these two regions. Current archaeological evidence therefore does not support any contacts between populations between the Levant and the Nile Valley at the end of the Pleistocene.


The visualization of chemical compounds in three-dimensions is a foundational skill in the study and practice of chemistry and related fields, and one which has the potential to be supported by interaction with virtual models. Here, we present a collaborative learning activity piloted in first-year chemistry which investigates if inquiry-driven interactive technology can contribute meaningfully to student conversations around this topic, and how students' conversations and practices may shift when driven by feedback from an interactive simulation. Our initial observations from this pilot project suggest that students engaged in collaborative sense-making and discussion around key ideas throughout this activity. Students' post-activity reflections also highlighted their positive experiences and increased confidence with the topic afterwards. The unique dynamics of these interactions lead us to propose a novel framing of interactive visualizations as participants rather than merely as resources in student learning conversations.


We investigate whether living arrangements respond to an arguably exogenous shift in the distribution of power in family economic decision-making. In the early 1990s, the South African Old Age Pension was expanded to cover most black South Africans above a sex-specific age cut-off resulting in a substantial increase in the income of older South Africans and potentially their say in the economic decisions of their families. Beneficiaries of the program are more likely to coreside with adults who have less human capital as measured by height and education. Since height and education are fixed for adults, this cannot be an effect of the pension income but reflects selective changes in living arrangements resulting from the pension. The findings highlight the endogeneity of living arrangements and illustrate the potential value of moving beyond theory and data that are confined to a spatially determined definition of the household.


A wave of attempted domestic terrorism attacks in 2009 and 2010 has sharpened attention to the threat of domestic-source terrorism inspired or directed by al Qaeda. Seeking to preempt that terror, governments face an information problem. They must separate signals of terrorism risk from potentially overwhelming background noise and persuade juries or fact finders that those signals warrant coercive action. Selection of accurate signals of terrorism danger in the information-poor circumstances of domestic counterterrorism is arguably a central challenge today for law enforcement tasked with preventing further terrorist attacks. To an underappreciated extent, governments have used religious speech as a proxy for terrorism risk in order to resolve this signaling problem. This Article analyzes the legal and policy significance of state reliance upon religious speech as a predictor of terrorism risk. Constitutional doctrine under the Religion Clauses does recognize interests implicated by the signaling function of religious speech. Yet analysis suggests that such doctrinal protection is fragile. Symptomatic of a wider inflexibility of pre-9/11 constitutional doctrine, this doctrinal protection shows little capacity for responsive change. The absence of constitutional barriers, however, does not mean government should persist in relying on religious speech as a signal. Rather, analysis of counterterrorism policy concerns suggests another path. Institutional considerations and an emerging social science literature on terrorism suggest that religious speech is ill suited to the signaling role it now plays. Instead, empirical social science on terrorism points to the epistemic superiority of a different signal: the close associations of a terrorism suspect. The Article concludes by examining the constitutionality of such a signal and elaborating ways that insight from the new social science of terrorism can be realized without compromising important individual interests.


There has been rapid growth in private equity (PE) investment in infrastructure over the last decade. This article is an analysis of PE funding in infrastructure based on data from Indian projects. Data from 335 infrastructure projects with PE investment and 370 projects with no PE investment have been used in the analysis. The average investment in projects made by foreign PE investors was higher than that of domestic PE investors. The average investment made by a mix of domestic and foreign investors was significantly higher than the average investment sizes of a group of either the domestic or foreign investors, suggesting that the presence of domestic investors increased the comfort level for foreign investors to enter the market. The main motivation for syndication was to pool capital from different investors. The overall characteristics of the operating environment also play an important role in attracting PE investment. States that had higher values of PPP and Property Right Indices and lower corruption levels attracted PE investment in more projects. Comparing the state level characteristics of projects with and without PE investment showed that PE investors are prepared to invest in riskier environments than other investors.


Today, the classical underpinnings of American legal education are under intense critical review. The dominant pedagogy, the case book and the Socratic method, were established by Christopher Columbus Langdell (1806-1906) at Harvard Law School more than a century ago. Together with Langdell's first year curriculum, which was exclusively focused on Anglo-American common law doctrine, and his emphasis on a competitive, anonymous graded meritocracy, this system still exercises an incredible grip on elite American law schools. But Langdell's 19th Century model has now been challenged by many rivals, including critical legal studies, law and economics empiricism, global curriculums, and clinical instruction. As is so often the case, Bacon anticipated these major forces of change. In his great De Augmentis Scientiarum (hereafter, De Augmentis), Bacon attacks the narrow parochialism of the common law pedagogy of his day. For at present there are nothing but schools and institutions for multiplying altercations and controversies on points of law, as if for the display of wit. And this evil is also an old one (Spedding ed., V, 108 De Augmentis Aphorism 93). Attacking reliance on decided judicial cases and on the parochial, prevailing common law treatises and pedagogy, Bacon evolved a new system of legal instruction based on empirical observation, distilled into maxims or aphorisms, one that sought true global significance and universal scientific legitimacy. [T]here are certain fountains of natural equity from which spring and flow out the infinite variety of laws which individual legal systems have chosen for themselves. And as veins of water acquire diverse flavors according to the nature of the soil through which they flow, just so in these legal systems natural equity is tinged and stained according to the site of territories, the disposition of peoples, and the nature of commonwealth. It is worthwhile to open and draw out the purer fountains of equity, for from them all amendment of laws in any commonwealth must be sought. The Aphorismi (Neustadt, ed., 273). This paper will set out Bacon's philosophy of legal education, analyze its fundamental pedagogical and doctrinal elements, and examine its lessons for American legal education today. In so doing, it will be necessary to traverse a minefield of controversy. As E.O. Wilson has so powerfully described in his book Consilience: The Unity of Knowledge (1998), Bacon was the grand architect of an enlightenment dream that called for the illumination of the moral and political sciences by the 'torch of analysis.' (Edward O. Wilson, Consilience: The Unity of Knowledge (New York, 1998), p. 23. (Hereafter, Consilience.)) Bacon was also devoted to a belief in a unity of knowledge, relying on the common means of inductive inquiry that might optimally serve all branches of learning. (Consilience, p. 27). In E.O. Wilson's words, Bacon envisioned a disciplined and unified learning as the key to improvement of the human condition. (Consilience, p. 27). But the unity of the modern legal academy has been fragmented into academic specialties and increasingly divorced from the experience of law practice. Post-modern and post-structuralist ideologies have attacked any pretense neutral and objective rule of law that could be taught in a formal, external setting, like mathematics or physics. Increasingly, law, and legal education, are seen as devoid of external truths. In E.O. Wilson's words: In the most extravagant version of this constructionism, there is no 'real' reality, no objective truths external to mental activity, only prevailing versions disseminated by ruling social groups. Nor can ethics be firmly grounded, given that each society creates its own codes for the benefit of the same oppressive forces. (Consilience, p. 40). Hence comes the post-modernist prohibition against universal truth . . . which can have particular force in modern legal pedagogy. Equally important, law practice itself has changed. The three qualities of modern law, described prophetically by Max Weber (1864-1920) and articulated in his great Law and Economy and Society, seem to be coming true. First, the legal ignorance of the layman has increased, as legal rules become more specialized, complex and technical. Most lawyers in modern firms are divided into such specialties, and usually have little or no idea of what their partners and associates actually do. Second, the anti-formalistic tendencies of modern legal development have led courts and tribunals to increasingly depart from objective or universal rules, and to rely instead on economical utilitarian meaning. Finally, there is the lay justice and corporate tendencies in the modern legal profession. Weber adds, The use of jurors and similar lay judges will not suffice to stop the continuous growth of the technical element in the law and hence its character as a specialist's domain. Add to those changes the rapid shrinking of world cultures by improved communications and the welcome, and dramatic, increase in cultural diversity throughout American law schools and American society generally, and it becomes clear that conventional legal pedagogies and curricula will come under great stress. The century old orthodoxy of American legal education could soon be shattered into a hundred unrelated pieces. Can Bacon help us?


Mock-epics were first created already in the antiquity and the most famous of them, the Batrachomyomachia, was translated into Estonian already in 1875 by Jaan Bergmann; it was also the first full translation of an ancient epic poem into Estonian. However, until now, no Estonian original mock-epics were known and this genre was presumed to have evolved in Estonian literature only in the 20th century, mostly used in parodies of the national epic, the Kalevipoeg.
In this issue, we introduce a new archival find from Jaan Bergmann's manuscript poetry book. We discovered that, having probably been inspired by the Batrachomyomachia, but perhaps also by Nikolay Osipov's Eneida (1791), Jaan Bergmann had created his own mock-heroic poem Jaaniida (1875). It is a multidimensional and poetically rich poem, interweaving different verse cultures and different eras. On the one hand, its analysis reveals clear influences of the Odyssey: there are parallels with the portrayal of the main hero, images and the plot, as well as with the Homeric epic techniques (for example, both epics begin with the prooemium, which contains an invocation). But in terms of poetic devices and versification, Jaaniida draws on Estonian folk songs, using the folk meter, plenty of alliteration and assonance as well as parallelism, and imitating their morphology and vocabulary. The storyline of the poem features events that appear to have happened only recently before the writing of the text (most probably in 1866–1875): the transition from villeinage to money rent and the cases of corruption among local administrators. Against this background, Bergmann satirically pictures the rise of an individual and his later downfall caused by his weaknesses and vices.


The debate on global warming is over (Stix, 2006 p24). The global community must now find ways to reduce greenhouse emissions, particularly from energy generation. Wind energy provides one of the potential solutions to generate renewable energy without creating harmful greenhouse gases. Wind energy is the fastest growing energy generation industry globally ('Operating wind power capacity' 2006a). This rapid growth is being driven by increasing global energy demand, commitment from governments globally to international agreements including the Kyoto Protocol (UNFCCC 1997) to reduce the emission of greenhouse gases, as well as individual country commitments to mandatory renewable energy targets. Australia, whilst being a signatory to the United Nations Framework Convention on Climate Change (UNFCCC) commitment to reduce greenhouse gas emissions, has so far failed to ratify the Kyoto Protocol. In Australia, wind energy development to date has been driven primarily by the development of the Mandatory Renewable Energy Target (MRET) under the Renewable Energy (Electricity) Act 2000. This requires a commitment to 2% of total electricity generation (9,500GW) to be derived from renewable energy sources by the year 2010 (Warwryk, undated). It is now understood, that the current federal obligation to renewable energy is now oversubscribed, and consequently the likelihood of further wind energy projects being developed is highly limited (Brazzale 2005). External to the government commitment to renewable energy, the development of wind energy projects requires a range of inputs including, but not limited to; an understanding of the wind resource, security of land, access to suitable electricity transmission grid, a market for the electricity, access to suitable technology and a level of community support. Whilst the literature related to project management and risk management is extensive, the literature related to the risks associated with wind energy development in Australia is limited. This research then seeks to fill a void that asks the question; How can project managers minimise the risk associated with wind energy developments in Australia? To investigate this research problem, comparative case study analysis was adopted as a methodology utilising a structured interview process of project managers responsible for the development of 8 Australian wind energy projects. This research shows that the greatest risk to Australian projects is the lack of security associated with the current federal legislation and the consequent loss of market value of the power from wind energy projects. A number of additional primary and secondary risks are identified by the interview participants, and the research is able to draw out three common themes of risk management strategies. These three themes were categorised as conservatism, due diligence and proactivism. This study contributes to the research associated with project management, risk management and wind energy development. This insight into the Australian wind energy industry provides…


A novel polymer polybis(dimethyl stannyl)ferrocene was synthesized through both metal catalyzed intermolecular dehydrogenative condensation and ring-opening polymerization. This polymer was the first evidence of a dibridged polyferrocenyl stannane, and was found to be of low to moderate molecular weight by gel permation chromatography and 1H NMR spectroscopy. This polymer displayed extensive electronic communication observed previously synthesized monobridged ferrocenyl stannane polymers. The first tristanna-bridged 3.3]ferrocenophane was discovered through an amine coupling of a tin amine, and 1,1'bis(dimethyl stannyl) ferrocene. The [3.3]ferrocenophane displayed a strong interaction between connected ferrocenes despite the large distance, (8.49 Å) between Fe centers. Finally, a new and improved synthesis of 1,1,2,2-tetramethyldistanna-[2]ferrocenophane was found. This metal catalyzed intramolecular dehydrogenative coupling employs Pd2(dba)3 as a catalyst and yields 90% product. All products were characterized where possible 1H, 13C, and 119Sn NMR and UV-Visible spectrocopy, as well as through cyclic voltammetry and DFT modeling.


This article presents an intelligent fuzzy logic controller (FLC) for controlling single-body heaving wave energy converter (WEC) or what is widely known as "Point Absorber". The controller aims at maximizing the energy captured from the sea waves. The power take-off (PTO) limitations are addressed implicitly in the fuzzy inference system (FIS) framework. In order to enhance the WEC power capturing bandwidth and make it less susceptible to wave environment irregularities and the system parametric uncertainties, the controller is built to have a self-configurable capability. This also eliminates the need to repeatedly run in-situ tuning procedure of the fuzzy controller or switch between several controllers based on the operating conditions. The fuzzy membership functions (MFs) are optimally tuned using particle swarm optimization (PSO) algorithm. To alleviate the computational burden associated with performing on-line optimization, the fuzzy controller is tuned at a rate significantly lower than the system sampling time. The suggested PSO-FLC has shown promising results compared with the fixed structure fuzzy logic controller (FS-FLC) and other passive control strategies. Several computer simulations were carried out to evaluate the controller effectiveness by applying different sea-states and analyzing the resultant WEC dynamics.


Few names, apart from that of Leo Strauss, are invoked more often when discussing the American response to terrorism in recent years than that of Carl Schmitt. Schmitt, who was part of the German school of political thought known as the 'Conservative Revolution,' is widely regarded as having been one of the greatest legal minds of the twentieth century. He famously asserted that the most important function of the sovereign of a nation is not the drafting or enforcement of law, but rather his ability to decide when the law should be suspended in an emergency, and likewise his power to declare who the 'friend' and 'enemy' of a community is at any given moment. Alain de Benoist critiques those who claim Schmitt as an inspiration behind the American 'neoconservative' movement that held sway during the administration of President George W. Bush, showing that the politics of the 'war on terror' do not actually reflect Schmitt's ideas, in that American lack of respect for the traditional rules of war, and its determination to portray its enemies as embodiments of absolute evil rather than as representatives of legitimate polities, renders contemporary American politics thoroughly un-Schmittian. Benoist then goes on to analyse recent history from Schmitt's standpoint, showing that the efforts of the United States have been intended to preserve its global hegemony, whereas Schmitt believed that the world was developing into a multipolar one where many powers, rather than a single power, would dominate, a trend which is clearly at work in our time. Benoist demonstrates that Carl Schmitt was therefore a much greater visionary than the American neoconservatives, who failed to understand the geopolitical forces at work today. Alain de Benoist is the leading philosopher behind the European 'New Right' movement (a label which de Benoist himself rejects, perceiving himself to not fit into the usual Left/Right dichotomy), a metapolitical school of thought which he helped to found in France in 1968 with the establishment of GRECE (Research and Study Group for European Civilisation). He continues to write and give lectures and interviews. He lives in Paris. Arktos has previously made available his books The Problem of Democracy and Beyond Human Rights, both published in 2011.


Deep neural networks are used for a wide range of regression problems. However, there exists a significant gap in accuracy between specialized approaches and generic direct regression in which a network is trained by minimizing the squared or absolute error of output labels. Prior work has shown that solving a regression problem with a set of binary classifiers can improve accuracy by utilizing well-studied binary classification algorithms. We introduce binary-encoded labels (BEL) , which generalizes the application of binary classification to regression by providing a framework for considering arbitrary multi-bit values when encoding target values. We identify desirable properties of suitable encoding and decoding functions used for the conversion between real-valued and binary-encoded labels based on theoretical and empirical study. These properties highlight a tradeoff between classification error probability and error-correction capabilities of label encodings. BEL can be combined with off-the-shelf task-specific feature extractors and trained end-to-end. We propose a series of sample encoding, decoding, and training loss functions for BEL and demonstrate they result in lower error than direct regression and specialized approaches while being suitable for a diverse set of regression problems, network architectures, and evaluation metrics. BEL achieves state-of-the-art accuracies for several regression benchmarks. Code is available at https://github.com/ubc-aamodt-group/BEL_regression .


In the autumn of 1997 it was announced that Radio 4's programmes were to be rescheduled and a commitment was given that disability would become a mainstream issue for the network. The new schedule and the mainstreaming initiative were implemented in April 1998. One of the immediate effects of rescheduling was the disappearance of Does He Take Sugar?, the network's weekly programme which presented in-depth treatment of general disability issues. By way of replacement, You and Yours, Radio 4's consumerist programme of longstanding, was given the remit to include regular coverage of disability issues in its content. It was intended that the outcome of these decisions would be that regular coverage of disability would emerge from a niche slot within the network and be positioned within the mainstream of the network's output. On the one hand, the implementation of the proposal to mainstream disability yielded the possibility of an increase in the coverage of disability issues on Radio 4 in an integrated way. On the other hand it could mean a loss of effective and focused treatment of disability issues and a qualitative shift in the nature of coverage. The proposal to mainstream disability issues on Radio 4 thus touched on central issues concerning the treatment of socially disadvantaged groups and the quest for equality. Its implementation took place at a time when the UK disability movement was growing in political power, and disabled people in Britain were becoming aware of the promise of potentially beneficial socio-cultural changes reflected by developments such as the introduction of the Disability Discrimination Act CDDA 1995). This thesis examines three aspects of the introduction of the mainstreaming initiative and the early years of its implementation: a) it draws on interviews with key players, conversations with others involved, participant observation reports and documentary evidence to examine the rationale behind the mainstream initiative and, in the light of the decision to drop the network's programme which focussed on general disability issues (Does He Take Sugar?), it examines the decision to retain In Touch, the network's niche programme for blind or visually impaired listeners; b) it presents a quantitative and qualitative comparative analysis of the network's pre and post-mainstreaming treatment of disability issues. This includes analysis of ten editions of Does He Take Sugar? the disability issues covered in You and Yours during the months of September 1998, 1999,2000 and analysis of the series No Triumph, No Tragedy. presented by a former member of the Does He Take Sugar? team in the summer of 2000;


Using template waveforms from aftershocks of the Wenchuan earthquake (12 May 2008, M s 7.9) listed in a global bulletin and continuous data from eight regional stations, we detected more than 6000 additional events in the mainshock source region from 1 May to 12 August 2008. These new detections obey Omori's law, extend the magnitude of completeness downward by 1.1 magnitude units, and lead to a more than fivefold increase in number of known aftershocks compared with the global bulletins published by the International Data Centre and the International Seismological Centre. Moreover, we detected more M >2 events than were listed by the Sichuan Seismograph Network. Several clusters of these detections were then relocated using the double‐difference method, yielding locations that reduced travel‐time residuals by a factor of 32 compared with the initial bulletin locations. Our results suggest that using waveform correlation on a few regional stations can find aftershock events very effectively and locate them with precision.


Mineral deposit models strategically guide exploration. The lithologies from which these models are built have genetic connotations. Thus, rock classification must be accurate to ensure that mineral exploration is effective and successful. Rock classification is based on mineral proportions, and these are commonly determined by: (1) visual inspection, which is subject to large errors; (2) point counting, which is tedious and time-consuming; (3) image analysis of stained slabs or polished thin sections, which is expensive and constrained by the availability of appropriate stains; and (4) image analysis of spectrometric data, which is expensive. These features make rock classification difficult and undermine its quality, thereby negatively impacting geological conclusions and mineral exploration results. A novel alternative procedure for igneous rock classification involves using whole rock lithogeochemical data for classification on Streckeisen ternary diagrams. This approach employs several calculations that transform: (1) mass-based element concentrations (the original lithogeochemical data produced by the laboratory) sequentially into (2) unstandardized (do not sum to unity) molar element numbers; (3) unstandardized molar mineral numbers; (4) unstandardized volume mineral numbers; and finally (5) standardized (closed; sum to unity) volume mineral concentrations that estimate the mineral modes in rocks. These mineral mode estimates can then be plotted on (projected onto) Streckeisen ternary diagrams, to classify the rocks in the normal manner. This new approach has advantages over conventional classification strategies, in that it is relatively inexpensive, adaptable to all forms of igneous rocks, quantitative, accurate, and precise. Required petrographic information necessary to conduct such a classification includes only knowledge of chemical formulae of the 'essential' mineral assemblage. Essential minerals are, here, considered those minerals having concentrations exceeding 5% in 5% of the rocks under consideration. This criterion allows this lithogeochemical classification procedure to be applicable to a wide variety of igneous rocks. This lithogeochemical classification procedure has additional applications beyond the classification of plutonic igneous rocks. For example, if an essential mineral assemblage can be identified or hypothesized, classification of felsic or mafic volcanic rocks can also be achieved. Additionally, an essential mineral assemblage does not have to consist exclusively of igneous minerals. As a result, conversion from molar element numbers to molar mineral numbers can be undertaken using many mineral assemblages. This allows analogous lithogeochemical classification to be undertaken for almost any rock type (e.g. clastic sedimentary rocks, using the calculated proportions of quartz, feldspar, and clay minerals). Consequently, lithogeochemical calculation of the essential mineral modes in rocks can be used to establish mineral zoning maps in space or time, allowing exploration geoscientists to create down-hole logs depicting hydrothermal alteration mineral abundances, or surface maps of hydrothermal alteration zones on a mineral property. To demonstrate this new procedure, results from classifications of metaluminous, peraluminous, and alkaline felsic plutonic and volcanic rocks, and mafic and ultramafic plutonic and volcanic rocks are compared with mineral modes acquired by independent means (visual estimates, point counts, image analysis, spectrometry). These case studies demonstrate that the proposed lithogeochemical classification procedure is as or more accurate than conventional classification methods. Furthermore, because lithogeochemical samples are far larger, and thus more representative than the surfaces used to estimate mineral modes by conventional means, this lithogeochemical classification procedure is also far more precise. The resulting classification is thus especially effective when working with fine-grained rocks where mineral identification and volume estimation is difficult.


BACKGROUND
Infection with human herpesvirus 8 (HHV-8) has been consistently linked to Kaposi's sarcoma, but its mode of transmission, association with other cancers, and interaction with the human immunodeficiency virus type 1 (HIV-1) are largely unknown.

METHODS
Between January 1992 and December 1997, we interviewed 3591 black patients with cancer in Johannesburg and Soweto, South Africa. Blood was tested for antibodies against HIV-1 and HHV-8 in 3344 of the patients. Antibodies against HHV-8 were detected with an indirect immunofluorescence assay. The intensity of the fluorescent signal correlated well with the titers of antibodies (P<0.001). The relations among the presence of anti-HHV-8 antibodies, sociodemographic and behavioral factors, type of cancer, and the presence or absence of coexistent HIV infection were examined with the use of unconditional logistic-regression models.

RESULTS
Among the 3293 subjects with cancers other than Kaposi's sarcoma, the standardized seroprevalence of antibodies against HHV-8 was 32 percent, which did not differ significantly from the standardized seroprevalence among black blood donors. Among these 3293 patients, the prevalence of antibodies against HHV-8 increased with increasing age (P<0.001) and an increasing number of sexual partners (P=0.05) and decreased with increasing years of education (P=0.007); it was not strongly associated with HIV-1 infection. Anti-HHV-8 antibodies were more frequent among black than white blood donors (P<0.001). Among the 51 patients with Kaposi's sarcoma, the standardized seroprevalence of antibodies against HHV-8 was 83 percent, significantly higher than the prevalence among those without Kaposi's sarcoma (P<0.001). For 16 other specific types of cancer, including multiple myeloma (108 cases) and prostate cancer (202 cases), the variation in the standardized seroprevalence of antibodies against HHV-8 was not remarkable. At a given intensity of fluorescence of anti-HHV-8 antibodies, Kaposi's sarcoma was more frequent among HIV-1-positive patients than among those who were HIV-1-negative (P<0.001).

CONCLUSIONS
Among black patients with cancer in South Africa, the seroprevalence of anti-HHV-8 antibodies is high and is specifically associated with Kaposi's sarcoma, particularly at high titers.


The subject of this book was conceived when India's 'tiger crisis' was brewing in 2005. The country had just discovered that the tiger had become locally extinct from a premier Protected Area. The large public and media coverage led to formation of a Tiger Task Force, which pointed out that India's tiger conservation schemes had been lacking in collecting support from local communities. If a conservation scheme antagonizes local people, there is very little chance for success. With this background, we set out to test the utility of a new methodology. Conservation needed methods that could be employed on ground without having to wait for large scale policy change. And our method provides us that opportunity. Through this publication, we hope to bring the scientific community a little closer to answering pertinent questions about balancing stakeholder aspirations, natural justice, and prudence of environmental management. We hope that this work will contribute to societal discourse on incorporating local expectations in management of sensitive ecosystems, and would be useful to Protected Area managers, academicians and NGOs and all those working on natural resources management.


Abstract. Winter storms are the most costly natural hazard for European residential property. We compare four distinct storm damage functions with respect to their forecast accuracy and variability, with particular regard to the most severe winter storms. The analysis focuses on daily loss estimates under differing spatial aggregation, ranging from district to country level. We discuss the broad and heavily skewed distribution of insured losses posing difficulties for both the calibration and the evaluation of damage functions. From theoretical considerations, we provide a synthesis between the frequently discussed cubic wind–damage relationship and recent studies that report much steeper damage functions for European winter storms. The performance of the storm loss models is evaluated for two sources of wind gust data, direct observations by the German Weather Service and ERA-Interim reanalysis data. While the choice of gust data has little impact on the evaluation of German storm loss, spatially resolved coefficients of variation reveal dependence between model and data choice. The comparison shows that the probabilistic models by Heneka et al. (2006) and Prahl et al. (2012) both provide accurate loss predictions for moderate to extreme losses, with generally small coefficients of variation. We favour the latter model in terms of model applicability. Application of the versatile deterministic model by Klawa and Ulbrich (2003) should be restricted to extreme loss, for which it shows the least bias and errors comparable to the probabilistic model by Prahl et al. (2012).


Year-round school calendars take the usual 175-180 instruction days of the school year and redistribute them, replacing the usual schedule – nine months on, three months off – with a more "balanced" schedule of short instruction periods alternating with shorter breaks across all four seasons of the year. Over the past three decades, the number of schools using year-round calendars has increased ninefold, from 410 in 1985 to 3,700 in 2011-12 (Skinner, 2014). Over 2 million children now attend year-round schools – as many as attend charter schools – yet year-round schools have attracted relatively little attention from researchers and the public. In this chapter, I review the evidence for the effects of year-round calendars on test scores. Once thought to be positive, these effects now appear to be neutral at best. Although year-round calendars do increase summer learning, they reduce learning at other times of year, so that the total amount learned over a 12-month period is no greater under a year-round calendar than under a nine-month calendar. I also review evidence that year-round calendars make it harder to recruit and retain experienced teachers, make it harder for mothers to work outside the home, and reduce property values. When students' schedules are staggered, year-round calendars do offer a way to reduce school crowding – an alternative to busing or portable classrooms, and a low-cost alternative to new school construction.


ABSTRACT Despite the positive contributions of several European Union (EU) policies to reduce border barriers, the EU Cross-Border Review (CBR) initiative reaffirmed their relevance and persistence. Since 2018, the EU has supported the b-solutions initiative, specifically focused on tackling legal and administrative border obstacles, aiming to highlight replicable solutions which can contribute to reducing these obstacles. This article critically assesses the b-solutions and its contribution to reducing administrative and legal border obstacles, with an eye to promoting a more integrated European territory. It is concluded that b-solutions is a valid, yet insufficient, initiative to provide replicable solutions to mitigate cross-border barriers.


"Ajax with PHP 5" is a detailed overview of how to use PHP technologies to create interactive, fault-tolerant, and responsive web applications. This Short Cut first concentrates on the fundamentals of Ajax. Then it covers serving (or providing) content formatted in both XML and JSON. Finally, we completely immerse ourselves in the Ajax world and write two PHP applications that use each markup language on both the client and server. We encourage you to use the classes and examples given to produce your own rich Web 2.0-style applications.


Entanglement between blocks of energy-levels is analysed for systems exhibiting s-wave and p-wave superconductivity. We study the entanglement entropy and spectrum of a block of $\ell$ levels around the Fermi point, and also between particles and holes, in the ground state of Richardson-type Hamiltonians. The maximal entropy grows with the number of levels $L$ approximately as $1/2\log(L)$, as suggested by the permutational symmetry of the state at large coupling. The number of levels in the block around the Fermi surface with maximal entanglement is proposed as a measure of the number of {\em active Cooper pairs}, which correlates with standard estimates of this magnitude. The entanglement spectrum is always composed of a principal parabolic band plus {\em higher bands} whose disappearance signals a exact BCS state, e.g. in the Moore-Read line, while the Read-Green quantum phase transition is characterized by a maximum in their weight.


PURPOSE
Racial disparities in colorectal cancer (CRC) survival are documented, but there are few data on comparative response to chemotherapy. A subgroup analysis of a multisite National Cancer Institute-sponsored trial (N9741) was performed comparing outcomes of black and white patients with metastatic CRC receiving uniform treatment.

PATIENTS AND METHODS
Adverse events (AEs), response rate (RR), time to progression (TTP), overall survival (OS), and dose-intensity were examined as a function of self-reported race in 1,412 patients treated with irinotecan/fluorouracil, fluorouracil/oxaliplatin, or irinotecan/oxaliplatin. Pharmacogenetic analysis was performed on 486 patients with blood available for germline DNA analysis.

RESULTS
OS was 1.5 months shorter and TTP was 0.6 months shorter in black than white patients (OS: hazard ratio [HR] = 1.13; 95% CI, 0.90 to 1.42; TTP: HR = 0.91, 95% CI, 0.73 to 1.13); neither difference was statistically significant. RR was significantly higher in whites (41%) than blacks (28%; P = .008). Grade 3 or greater AEs were also higher in whites (48%) than blacks (34%; P = .004). These relationships were maintained in multivariate models adjusting for arm, age, sex, and performance status. There was no difference in dose-intensity of delivered therapy. Significant racial differences in prevalence of pharmacogenetic variants were observed, although small sample size precluded investigating the relationship between treatment, race, and genotype.

CONCLUSION
OS and TTP are similar in black and white patients treated per protocol with standardized therapy for metastatic CRC. However, RR and AEs vary considerably by race. The marked racial differences in relevant pharmacogenetics, a potential explanation for differing RR and AEs, are worthy of future study.


This article argues that the EU's GATT and GATS schedules are binding on the UK in its own right, in respect of UK territory, and will continue to be binding on the UK following Brexit. Establishing a new schedule is straightforward except for a small minority of commitments expressed in quantitative terms. Determining the UK's share of these quantities depends on identifying the correct legal principle, and this would be best done by the agreement of any affected exporting WTO Members. If such agreement fails, however, the UK's obligations are limited to compensation for any trade damage, set against the benchmark of its existing commitments. Any such damage is likely to be slight, and relatively easily compensable. In other words, the UK's position in the WTO post-Brexit is much more secure than many have said.


Attending high-quality early education or care (ECE) is positively associated with short-term academic outcomes for children (Yoshikawa et al., 2013) as well as longer-term social and behavioral (Heckman, Moon, Pinto, Savelyev & Yavitz, 2010). Despite the demonstrated benefits of early care and education (ECE) for children with immigrant parents (Puma et al., 2010), participation rates are lower among children of immigrants than children with native-born or citizen parents among threeto fiveyear-olds (Hernandez, Denton, & McCartney, 2007). There are many barriers to accessing ECE programs for immigrants, which may be exacerbated for undocumented immigrants. Specific immigration policies may either restrict or facilitate access to ECE (Hanson, Adams, & Koball, 2016; Greenberg, Adams & Michie, 2016). One such state-level immigrant policy that may be associated with increased ECE participation is access to a driver's license (DL) for undocumented immigrants (Hacker, Chu, Lueng, Marra, Pirie, Brahimi & Marlin, 2011; Hanson, Adams & Koball, 2016). The present study examined the association between state-level, legal opportunities to access DLs for undocumented immigrants and rates of participation in ECE among their threeto five-year-old children using a cross-sectional, quasiexperimental design. The three states examined in this study were used were: (1) New Mexico, which implemented a DL policy in 2003, (2) Utah, which implemented a DL policy in 2005, and (3) California, which passed a DL policy in 2004, but never enacted the policy. Panel data from the 1996, 2001, 2004 and 2008 Survey of Income and Program Participation (SIPP) administrations were accessed to determine legal immigration status of household members and participation in ECE. The sample was comprised of 4,709 households with undocumented members that included children between threeand five-years-old. Synthetic control models were used to compare ECE participation rates in states that had enacted DL policies to ECE participation rates estimated for synthetic controls. Results indicated that access to a DL for undocumented immigrants was associated with small but consistent differences in ECE participation, where participation rates were higher among children of undocumented immigrants in states with DL access than in control states in the post-policy period by three to five percentage points. Although future research is needed to further explore this association and to examine access to DLs at the household level, results provide preliminary evidence that driver's licenses facilitate participation in ECE, and this may be regardless of the stringency of the policy. Results have implications for assessing DL policies as a way to integrate undocumented immigrants and their households into society and improve later outcomes for their children.


: The Fluid flow mechanism in unconventional reservoirs is much more complicated than that in conventional reservoirs mainly because of the co-existing of various sized micro-nano pores and natural / artificial fractures in the same reservoir. Due to the various flow patterns and seepage mechanism among different-sized medium, and also among different production periods in the same medium, the dynamic production is influenced by both the spatial variable and time variable. The capacity of the tight oil reservoirs is also thus greatly influenced. In this paper, numerical simulation is used to automatically identify the flow pattern according to the critical criteria of flow in different medium, and to simulate the dynamic production process with kinetic equations. The simulation is mainly focused on the following characteristics shown in the production process of tight oil reservoirs: I) high-velocity nonlinear, quasi-linear and low-velocity nonlinear flow regimes; II) flow patterns and seepage mechanism among different-sized medium in the same production periods; and III) flow patterns and seepage mechanism among different production periods in the same medium. The simulation results reveal that: a) as the start-up pressure gradient increases, the production gradually decreases; b) the higher the high-velocity non-Darcy coefficient, the lower the production; c) the higher the nonlinear seepage coefficient n value, the higher the production; d)in the same production stage, the flow regime in different locations and porous-fractured media have great differences. Also, at the same location, it changes drastically at different production stages. Based on the above analysis, a better understanding about the influence of the flow state and seepage mechanism on dynamic production and productivity is obtained, which will help optimizing the development method and improving the accuracy of oil well productivity forecasting.


Explanatory problems in the philosophy of neuroscience are not well captured by the division between the radical and the trivial neuron doctrines. The actual problem is, instead, whether mechanistic biological explanations across different levels of description can be extended to account for psychological phenomena. According to cognitive neuroscience, some neural levels of description at least are essential for the explanation of psychological phenomena, whereas, in traditional cognitive science, psychological explanations are completely independent of the neural levels of description. The challenge for cognitive neuroscience is to discover the levels of description appropriate for the neural explanation of psychological phenomena.


Abstract Carbon and oxygen isotope compositions of pedogenic carbonate preserved in paleosols have been used extensively to reconstruct ancient environmental conditions. One concern is that pedogenic carbonate precipitated in association with a limestone parent material may include a contribution from inherited detrital (lithogenic) marine calcite, thus compromising interpretations of stable-isotope compositions. To investigate the impact of lithogenic calcite on environmental interpretations using paleosols, we measured stable-isotope ratios in pedogenic carbonates and coexisting soil organic matter (SOM) in modern Vertisols (fine, smectitic, thermic, Udic Haplusterts) from Riesel, Texas (Heiden series) and Zabcikville, Texas (Houston Black series) forming on Cretaceous chalk deposits. The pedogenic and lithogenic components in the Heiden series soil at Riesel were identified using micromorphology and cathodoluminescence (CL), which showed incorporation of luminescent marine allochems (i.e., foraminifera, mollusks) into hard nodules and soft powdery pedogenic masses. Additionally, micromorphology showed evidence of meteoric recrystallization of the allochems. Despite the presence of these inherited carbonates into hard nodules and soft powdery masses, the stable-isotope compositions recorded a partial pedogenic signal. Recrystallization of the marine allochems resulted in overprinting of primary marine isotope ratios with ratios that are more similar to those expected for pedogenic carbonates in these soils. This study demonstrates that incorporation of parent material into pedogenic carbonates does not necessarily compromise the pedogenic signal that is useful for paleoenvironmental reconstructions. However, overprinting of marine allochems, if present, can be important and needs to be identified using micromorphology and cathodoluminescence, before using stable-isotope ratios of pedogenic carbonates for paleoenvironmental reconstructions.


E. coli ribosomal proteins are retained by nitrocellulose filters. In contrast, 16S RNA passes through nitrocellulose filters. We have found that specific protein-RNA complexes involving single proteins also pass through nitrocellulose filters. Thus, by utilizing radioactively labeled r-proteins, nitrocellulose filtration can be used to study directly and sensitively the stoichiometry of r-protein-RNA association. The filtration process maintains near equilibrium conditions, making it applicable to weak as well as strong protein-RNA associations. We have used nitrocellulose filtration to obtain saturation binding curves for the association of proteins S4, S7, S8 and S20 with 16S RNA. In each case, the stoichiometry of binding was one mole of protein or less per mole of RNA. The stoichiometry of protein S8 binding to 16S RNA measured by filtration is comparable to that observed by sucrose gradient centrifugation. Association constants for the binding of proteins S4, S8 and S20 to 16S RNA have been determined by analysis of the saturation binding curves and were found to range from .3-6 X 10(7)M-1.


Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been reported to specifically kill malignant cells but to be relatively nontoxic to normal cells. To evaluate the antitumor activity and therapeutic value of the TRAIL gene, we constructed adenoviral vectors expressing the humanTRAIL gene and transferred them into malignant cells in vitro and tumors in vivo. The in vitro transfer elicited apoptosis, as demonstrated by the quantification of viable or apoptotic cells and by the analysis of activation of pro-caspase-8 and cleavage of poly(ADP-ribose) polymerase. The intratumoral delivery elicited tumor cell apoptosis and suppressed tumor growth. In comparison withBax gene treatment, which is toxic to normal cells, TRAIL gene treatment caused no detectable toxicity in cultured normal fibroblasts nor in mouse hepatocytes after systemic gene delivery. Furthermore, coculture of cancer cells expressing TRAIL with those expressing green fluorescent protein (GFP) resulted in apoptosis of both cells, whereas coculture of Bax-expressing cells with GFP-expressing cells resulted in the cell death of the Bax-expressing cells only, which suggested that the transfer of theTRAIL gene resulted in bystander effects. Moreover, culture of cells with medium from TRAILexpressing cells showed the proapoptotic activity and bystander effect of the TRAIL gene to be not transferable with medium. To further demonstrate the bystander effect of theTRAIL gene, we constructed plasmid vectors encoding GFP-TRAIL or GFP-Bik chimeric proteins. Transfection of the GFP-TRAIL gene into cancer cells resulted in the death of GFP-positive cells and their neighbors, whereas transfection of the GFPBik gene killed GFP-positive cells only. Finally,GFP-TRAIL genes, transfected into normal human fibroblasts or bronchial epithelial cells, did not kill such cells, whereas transfected GFP-Bik genes did. Thus, the direct transfer of the TRAIL gene led to selective killing of malignant cells with bystander effect, which suggests that theTRAIL gene could be valuable for treatment for cancers. Together, these results suggest that delivering the TRAIL gene to cancerous cells may be an alternative approach to cancer treatment.