Abstract Learning associations between co-occurring events enables us to extract structure from our environment. Medial-temporal lobe structures are critical for associative learning. However, the role of the ventral visual pathway (VVP) in associative learning is not clear. Do multivoxel object representations in the VVP reflect newly formed associations? We show that VVP multivoxel representations become more similar to each other after human participants learn arbitrary new associations between pairs of unrelated objects (faces, houses, cars, chairs). Participants were scanned before and after 15 days of associative learning. To evaluate how object representations changed, a classifier was trained on discriminating two nonassociated categories (e.g., faces/houses) and tested on discriminating their paired associates (e.g., cars/chairs). Because the associations were arbitrary and counterbalanced across participants, there was initially no particular reason for this cross-classification decision to tend toward either alternative. Nonetheless, after learning, cross-classification performance increased in the VVP (but not hippocampus), on average by 3.3%, with some voxels showing increases of up to 10%. For example, a chair multivoxel representation that initially resembled neither face nor house representations was, after learning, classified as more similar to that of faces for participants who associated chairs with faces and to that of houses for participants who associated chairs with houses. Additionally, learning produced long-lasting perceptual consequences. In a behavioral priming experiment performed several months later, the change in cross-classification performance was correlated with the degree of priming. Thus, VVP multivoxel representations are not static but become more similar to each other after associative learning.


This book explores the potential and problems of bank safety and efficiency arising from the rapidly growing area of cross-border banking in the form of branches or subsidiaries with primarily only national prudential regulation. There are likely to be differences in the treatment of the same bank operating in different countries or of different banks from different home countries operating in the same country with respect to deposit insurance provisions, declaration of insolvency, resolution of insolvencies, and lender of last resort protection. The book identifies these protection problems and discusses possible solutions, such as greater cross-border cooperation, harmonization and organizations.


A new system for measuring the oxygen saturation of blood within tissue has been developed, for a number of potential patient monitoring applications. This proof of concept project aims to address the unmet need of real-time measurement of oxygen saturation in the central nervous system (CNS) for patients recovering from neurosurgery or trauma, by developing a fibre optic signal acquisition system for internal placement through small apertures. The development and testing of a two-wavelength optical fibre reflectance photoplethysmography (PPG) system is described together with measurements in rats and preliminary results from a clinical trial of the system in patients undergoing neurosurgery. It was found that good quality red and near-infrared PPG signals could be consistently obtained from the rat spinal cord (n=6) and human cerebral cortex (n=4) using the fibre optic probe. These findings justify further development and clinical evaluation of this fibre optic system.


Traumatic injury to the eye can occur due to various causes, most of which are avoidable. Here we report three cases of intrastromal corneal foreign bodies (FB) which required surgical removal. Most corneal FBs are removed easily at the slit lamp, however, these cases required surgical intervention due to the mechanism of which the FB penetrated into the stroma. Although the mechanism of injury was similar, with all three cases occurring at high velocity, we observed that the entry and level of penetration differed in each case. In the first case, the corneal FB penetrated the cornea and was embedded in the anterior stroma, whereas in the second case, the FB was embedded in the posterior stroma, but with an intact endothelium. In the third case, the FB caused a full thickness, self-sealed laceration wound but remained embedded in the stroma. Through further evaluation, we noted that several factors contribute towards the severity of the injury, namely, anatomy of the cornea, area affected, shape, size, mass and velocity of the object. We speak in depth about the mechanism of injury and physics associated with these injuries and why the penetration differed in each case.


Here, we explore 200 years of arthropod succession by using dated moraines in a Norwegian glacier foreland. Surface active beetles (Coleoptera) and spiders (Aranea) were sampled by pitfall trapping, and springtails (Collembola) and mites (Acari) were extracted from soil samples. Newly deglaciated ground was rapidly colonised by a mixture of generalists and specialists, with various life strategies. Interestingly, the pioneer community was fed by three 'invisible' food sources: biofilm with terrestrial diatom algae, tiny pioneer mosses and chironomid midges whose larvae were pond-living and used ancient carbon that was released by the melting glacier as an energy source. The true 'super-pioneers' were biofilm-eating springtails, which tracked the melting ice edge closely. Most species of beetles and springtails colonised within 80 years, while spiders and oribatid mites needed a longer time span to colonise. Topography influenced the succession pattern. Among both surface-living macroarthropods and soil-living microarthropods, we distinguished between a 'dry' and a 'wet' successional pathway with different community structure. Most arthropod species persisted after colonisation, but certain species preferring open space or low temperature were gradually excluded. Comparisons are made with botanical succession. Sampling methods, material size, and taxonomic resolution were considered critical factors when studying arthropod succession.


The power spectrum of the difference angle of arrival of two parallel rays through turbulent air is computed and the results compared to data and to earlier theoretical work on the subject. The present theory predicts an f−2/3 power law in the inertial subrange, and thus differs significantly from Tatarski's, which predicts an f−2/3 power law. Nevertheless, it fits the existing data in the f−2/3 region common to both theories. The interferometer situation introduces a filter factor that is unimportant for most vertical interferometers in turbulent air, except at very low frequencies.


This Article shows how Posner and other scholars who claimed that common law was efficient misunderstood the structure of common law. If common law was more efficient, there would have been a noticeable push across most, if not all, doctrines to greater efficiency. This has not been the case. Rather, common law, better recast as a "platform," could, under a certain set of parameters, lead to efficient outcomes. Next, the Article's analysis suggests that while not every judge thinks about efficiency in decision-making, there must be some architectural or governance feature pushing in the direction of efficiency — which exists in some areas of law and not in others. This Article explains two-sided markets, or platforms, generally and applies the modular open-source platform model to judge made law. In doing so, it explores concepts that impact the efficiency of such platforms — platform governance, modularity, and fragmentation. Then, the Article applies the understanding of platforms to several areas of law that might be understood as more prone to economic analysis because the issues addressed in law tend to be more "economic," such as torts, bankruptcy, patents, and corporations. In these areas, no combination of platform architecture and modularity has allowed for the development of more efficient legal rules as a general matter. Finally, this Article studies antitrust law as the one area of law that suggests that the efficiency of common law is possible and the causal mechanism of necessary conditions that needs to be met. Antitrust law is different than other areas of law because of a singular goal, an architectural governance based on a single federal court (the Supreme Court) with few substantive legislative changes for the past 100 years, which provides for coherent governance of the platform. The Article concludes by discussing the implications of an efficient platform design for other areas of law.


Aggressive compiler optimizations are formulated around the Program Dependence Graph (PDG). Many techniques, including loop fission and parallelization are concerned primarily with dependence cycles in the PDG. The Directed Acyclic Graph of Strongly Connected Components (DAGSCC) represents these cycles directly. The naive method to construct the DAGSCC first computes the full PDG. This approach limits adoption of aggressive optimizations because the number of analysis queries grows quadratically with program size, making DAGSCC construction expensive. Consequently, compilers optimize small scopes with weaker but faster analyses. We observe that many PDG edges do not affect the DAGSCC and that ignoring them cannot affect clients of the DAGSCC. Exploiting this insight, we present an algorithm to omit those analysis queries to compute the DAGSCC efficiently. Across 366 hot loops from 20 SPEC2006 benchmarks, this method computes the DAGSCC in half of the time using half as many queries.


Objective: This case study elaborates on the theme of crisis planning and addresses the question of the use of crisis plans in actual crises. Using Merton's concepts, the article considers the manifest and latent consequences of prepared crisis plans. Method: The study is based on data collected during one particular incident, consisting of interviews, notes, and observations at a Municipal Council, County Administrative Board, and County Council in Sweden. Result: The results show that the organizations did not use their crisis plan during the incident. The most important factor was the drawing up of the plan. Even if the plan did not cover the specific set of problems that arose, it helped people think systematically about how to handle this new crisis. Conclusion: The crisis plan's latent function prepared officials for what to do in an emergency.


A small reactor has the potential to be utilized as a power source to meet diverse social needs and reduce capital risks. In remote areas, populations tend to be small, and an economic power grid may not be available. In such situations, a small power source with a capacity of less than 50 MW(electric) without refueling is attractive since the costs for fuel transfer to such a site are expensive. In the present study, a metal fuel core with a lifetime of 30 yr and a simple reactor plant design has been proposed. The local burnup reactivity change in every core region is minimized by adjusting the zirconium content and the smear density of the three-core region to achieve a 550°C core outlet temperature. At the end of the cycle, the burnup reactivity is evaluated to be 1.1% of (dk/kk'), achieving a 30-yr core life. The reactor vessel is dramatically simplified by eliminating a fuel-handling system. The number of main cooling loops is reduced to one by installing dual electromagnetic pumps in the primary sodium circuit. The nuclear steam supply system mass, at 309 tonnes, shows that the present loop-type concept can more dramatically reduce material mass than that of the previous pool-type concept of 484 tonnes. The rough estimation of the electricity cost shows that this concept will be competitive for remote sites. Transient analyses show that a self-actuated shutdown system enhances the passive safety features, thus ensuring reactor integrity in anticipated transient without scram events.


We extend the traditional active learning framework to include feedback on features in addition to labeling instances, and we execute a careful study of the effects of feature selection and human feedback on features in the setting of text categorization. Our experiments on a variety of categorization tasks indicate that there is significant potential in improving classifier performance by feature re-weighting, beyond that achieved via membership queries alone (traditional active learning) if we have access to an oracle that can point to the important (most predictive) features. Our experiments on human subjects indicate that human feedback on feature relevance can identify a sufficient proportion of the most relevant features (over 50% in our experiments). We find that on average, labeling a feature takes much less time than labeling a document. We devise an algorithm that interleaves labeling features and documents which significantly accelerates standard active learning in our simulation experiments. Feature feedback can complement traditional active learning in applications such as news filtering, e-mail classification, and personalization, where the human teacher can have significant knowledge on the relevance of features.


Ear rots caused by Fusarium spp. are a major concern in many maize (Zea mays L.)-growing regions of the world. Our objectives were (i) to evaluate a set of European maize inbreds for resistance to ear rots and mycotoxin concentrations, (ii) to estimate variance components and heritabilities, and (iii) to compute correlations among resistance traits. Forty-two inbreds were evaluated for resistance to F. graminearum in four environments, and 21 inbreds were evaluated for resistance to F. verticillioides in three environments, under artificial inoculation. Data were recorded on severity of Gibberella (AGER) and Fusarium ear rots and accumulation of deoxynivalenol (DON), zearalenone, and fumonisins. Artificial inoculation was effective particularly for Gibberella ear rot. Genotypic and genotype x environment interaction variances were generally significant. Heritability estimates were moderate to high. Disease severity had strong correlations with respective mycotoxin concentrations. Selection for resistance is expected to have favorable correlated response for mycotoxins particularly with respect to AGER and DON (r p = 0.94). We recommend conducting initial selection on the basis of visual ratings and evaluate the selected elite material for mycotoxin concentrations.


Three-dimensional (3D) modeling of the flow around a circular cylinder in a steady, uniform current subjected to low and intermediate Reynolds numbers (Re) is considered. Large eddy simulations (LES) are used to simulate the flow due to their ability to study fine structures in the turbulent wake of the cylinder. The turbulence is resolved by the Smagorinsky model. The open-source code OpenFOAM is used in the simulations. Influences of various numerical parameters, such as the grid resolution close to the cylinder, domain width and spanwise resolution are investigated through mean values of the drag and the lift coefficients, the Strouhal number, as well as through the details of the flow field in the near wake of the cylinder.The main purpose of the present paper is to study the numerical influences on the 3D LES simulations of the flow around the cylinder in the free stream at Re = 13100. However, first the flow around a cylinder in the free stream at Re = 3900 is investigated. The latter case has previously been thoroughly investigated, both with LES and direct numerical simulations (DNS); hence these results will be used for verification of the OpenFoam solver.At Re = 13100 the drag and lift coefficients and the Strouhal number are calculated for the comparable Re. Details of the flow in the intermediate wake of the cylinder are also investigated. So far, this has been investigated experimentally and by two-dimensional (2D) numerical simulations. Previous studies were conducted for moderate Re in the range 103–105.Copyright © 2012 by ASME


Higher immigration can ease, but not entirely mitigate, the impacts of demographic change on the workforce, according to a new report from the C.D. Howe Institute. In "Inflated Expectations: More Immigrants Can't Solve Canada's Aging Problem on Their Own" authors William B.P. Robson and Parisa Mahboubi encourage governments to adopt policies to complement immigration that are necessary for Canada to meet its demographic challenge.


Sedimentation (primarily from human land use) is a major threat to runoff-fed wetlands of the Great Plains of North America (playas), but it is unknown how many playas are turbid, how prevalence of turbidity has changed over time, and how turbidity is related to surrounding land use. We used remotely sensed imagery to assess sedimentation in the waters of over 7700 playa basins in Texas on four dates during a 29-year span: 25 July 1986 (a regionally wet time), 3 May 2014 (during drought), 4 June 2014 (after the drought was broken), and 25 July 2015 (one year post-drought). Even on the wettest date examined, 64% of playa basins did not hold water. Turbidity varied over time, was already present in over half of the basins examined in 1986, and prevalence of turbidity was not simply proportional to overall wet playa abundance. There was an increase in total and irrigated cropland in our focal region and a statistically significant association between sedimentation and land use within 100 m of a playa: clear playas were associated with more urban development and pasture/grassland, and turbid playas were surrounded mostly by cropland.


Abstract Background Understanding the contribution of efflux pumps to the resistance of antibiotics is useful when considering strategies for antimicrobial therapy. Objectives To assess the role of efflux activity on the resistance of antibiotics commonly used in hospitals. Methods We analyzed the efflux activity of 120 clinical isolates of Acinetobacter baumannii using an Hoechst 33342 (H33342) dye-accumulation assay. We compared the indicators for efflux activity of susceptible and non-susceptible groups of each of 16 tested antibiotics. To determine the role of efflux activity on resistance to an antibiotic, we used 3 criteria based on the results of the H33342-accumulation assay. Results The evaluation suggests that efflux activity contributed to resistance to the following 11 antibiotics: cefepime, cefotaxime, ceftazidime, ciprofloxacin, gentamicin, imipenem, meropenem, piperacillin, piperacillin/tazobactam, ticarcillin/ clavulanic acid, and tigecycline. However, ampicillin/sulbactam, minocycline, and trimethoprim/sulfamethoxazole did not meet the criteria, suggesting resistance may not be mediated by efflux activity. A significant difference in efflux activity was observed between bacteria belonging to the multidrug-resistant Acinetobacter baumannii (MDRAB) group and those belonging to the non-MDRAB group. Conclusions Efflux activity may contribute to multidrug resistance and particularly resistance to numerous antibiotics used in hospitals. These antibiotics would be good candidates for combination therapeutic regimens consisting of an antibiotic and an efflux pump inhibitor as an adjuvant to combat drug efflux.


ABSTRACTThe present study evaluates the temporal variation of aerosol optical depth (AOD500 nm) and the Angstrom parameters [viz., Angstrom exponent (AE, α), Angstrom turbidity coefficient (β) and second order Angstrom exponent (α′)] at a tropical observing site, Pune (18°32′N; 73°49′E, 559 m AMSL) during 2008–15. Six-year means for winter and pre-monsoon seasons together are found to be 0.534 ± 0.13, 1.054 ± 0.27, 0.254 ± 0.08 and 0.167 ± 1.33 for AOD500 nm, AE, β and α′ respectively. Average month-to-month variability of AOD500 nm, AE, β and α′ during 2008–15 depicts seasonal cycle with strong departures with respect to long-term means. Frequency distributions for AOD, AE and β are positively skewed (skewness = 0.77, 0.32 and 1.14 respectively) while it is negatively skewed for α′ (skewness = –0.18). Analysis of AE difference, curvature parameter difference (α2–α1) and AOD500 nm–AE440-870 nm contour density map reveals that the aerosol ensemble at Pune consists of four aerosol types viz., UI (urban/industrial), CM (clear maritime), DD (desert dust) and MT (mixed type). Their relative magnitudes, however, differ during winter and pre-monsoon seasons. Thus, the contour density map shows dominance of UI and relatively less occurrence of MT type aerosols during winter. In pre-monsoon, however, the aerosol scenario is driven by MT type aerosol although UI and DD type aerosols show their remarkable existence.


Political Ecology addresses environmental issues which Innis was concerned with, from a contemporary, political economy perspective. They explore a wide range of themes and issues including: * sustainability * risk and regulation * population growth * planetary management * impact of humanity on environment * role of technology and communication. Case studies provide further insight into issues such as industrial racism, women and development and collective action by highlighting ethical and political questions and providing critical insights into the issues and debates in political ecology.


In the last several years, economists have learned about an antitrust problem of vast scope. Far from approximating the conditions of perfect competition as long assumed, most labor markets are characterized by monopsony — meaning that employers pay workers less than their productivity because workers lack a credible threat to quit and find a higher-paying job in the same market. Yet while antitrust law regulates labor monopsony in the same way as it regulates monopoly on the product market side, antitrust litigation against employers is rare. We document both the magnitude of labor monopsony and the paucity of cases, and argue that this "litigation gap" exists because antitrust case law, which has developed through product-side litigation, is poorly tailored to labor-side problems. We conclude with four proposals for reform of antitrust law so it can better deter labor monopsony.


General side view, from the southwest, depicting the entire facade; After 1980, associated with Borja Huidobro, Chemetov won several major commissions through competitions. The Ministry building is located between the river and the Gare de Lyon, close to the Palais Omnisports de Bercy by Andrault and Parat. Like the Evry urban project and many of his other housing schemes, it was designed as an urban complex, incorporating a spine, like a viaduct, bridging from the river to the railway. Low-rise, narrow, rectilinear buildings are placed in a grid at right angles on one side of the spine, with landscaping on the other. Source: Grove Art Online; http://www.groveart.com/ (accessed 12/27/2007)


In this work we discuss the effect of infiltration of different antiresonant fibers with low-refractive-index liquids, such as water and ethanol, on their optical properties. The fibers with single- and double-ring capillaries have been designed to show broad transmission bands in visible and near infrared range as it is required for optofluidics, in particular spectrophotometric applications. We show experimentally that their transmission windows shift toward shorter wavelengths and only modestly reduce their width. The transmission bands are located in the wavelength ranges of 533-670 nm and 707-925 nm, for the fibers when infiltrated with water. The two types of analyzed antiresonant fibers infiltrated with the liquids show similar light guidance properties when they are straight, but significantly lower bending loss can be achieved for the double-ring than for the single-ring antiresonant fiber. For this reason, the double-ring antiresonant fibers are more suitable as a compact solution for optofluidic applications, although transmission windows are reduced due to broader resonance peaks.


Development discourses often assume linear rural transitions, in which
educated young people are supposed to leave their rural communities, becoming
urban. However, drawing on fieldwork in Flores (East Indonesia), I argue that
tertiary educated young people do return to their natal communities upon graduation.
There, they want to act—by virtue of their education—as vanguards of
positive change and alter what they consider backward, rural livelihoods and practices.
Yet, educated young people often depend on these livelihoods and practices,
too, especially when they cannot obtain work, which is common in rural Flores.
To better understand the tensions inherent to these young people's position within
their rural communities, I map the reasons for their returns to rural Flores.


Regenerative ability varies tremendously across species. A common feature of regeneration of appendages such as limbs, fins, antlers, and tails is the formation of a blastema--a transient structure that houses a pool of progenitor cells that regenerate the missing tissue. We have identified the expression of von Willebrand Factor D and EGF Domains (vwde) as a common feature of blastemas capable of regenerating limbs and fins in a variety of highly regenerative species. Further, vwde expression is tightly linked to the ability to regenerate appendages. Functional experiments demonstrate a requirement for vwde in regeneration and indicate that Vwde is a potent mitogen in the blastema. These data identify a key role for vwde in regenerating blastemas and underscore the power of an evolutionarily-informed approach for identifying conserved genetic components of regeneration.


OBJECTIVES
Medicaid enrollees disproportionately experience dental disease and difficulties accessing needed dental care. However, little has been documented on the factors associated with the acceptance of new Medicaid patients by dentists, and particularly whether minority dentists are more likely to accept new Medicaid patients. We therefore examined the factors associated with the acceptance of new Medicaid patients by dentists.

METHODS
We analyzed 2001 data from the Wisconsin Dentist Workforce Survey administered by the Wisconsin Division of Health Care Financing, Bureau of Health Information. We used descriptive statistics and logistic regression analysis to examine the factors associated with the outcome variable.

RESULTS
Ninety-four percent of Wisconsin licensed dentists (n = 4,301) responded to the 2001 survey. A significantly higher likelihood of accepting new Medicaid patients was found for racial/ethnic minority dentists (35 versus 19 percent of White dentists) and dentists practicing in large practices (31 versus 16 percent for those in smaller practices). In the multivariable analysis, minority dentists [odds ratio (OR) = 2.06, 95 percent confidence interval (CI) = 1.30, 3.25] and dentists in practices with >3 dentists (OR= 2.25, 95 percent CI = 1.69, 3.00) had significantly greater odds of accepting new Medicaid patients.

CONCLUSIONS
Racial/ethnic minority dentists are twice as likely as White dentists to accept new Medicaid patients. Dentists in larger practices also are significantly more likely than those in smaller practices to accept new Medicaid patients. These findings suggest that increasing dental workforce diversity to match the diversity of the general US population can potentially improve access to dental care for poor and minority Americans, and may serve as an important force in reducing disparities in dental care.


The objective of this study was to analyse interventions for the prevention of overweight and obesity in children under 5 years of age. We carried out a systematic review focusing exclusively on randomized controlled trials (RCTs). Data sources include Medline, Cochrane Library, EMBASE, CINHAL, PsychInfo and Web of Science. Data were extracted from seventeen articles describing seven RCTs identified through electronic search, screening of references in systematic reviews, own files and contact with authors. RCTs were assessed with the Jadad scale. Four trials were carried out in preschool settings, one with an exclusive educational component, two with an exclusive physical activity component and one with both. Two trials were family‐based, with education and counselling for parents and children. The remaining trial was carried out in maternity hospitals, with a training intervention on breastfeeding. None of the interventions had an effect in preventing overweight and obesity. The failure to show an effect may be due to the choice of outcomes, the quality of the RCTs, the suboptimal implementation of the interventions, the lack of focus on social and environmental determinants. More rigorous research is needed on interventions and on social and environmental factors that could impact on lifestyle.


This Article explores the unfortunately large number of instances in which appellate courts reverse convictions for serious prosecutorial misconduct but do not identify the names of the prosecutors who committed that misconduct. Because judges are reluctant to publicly shame prosecutors whose cases are reversed, this Article advocates that a neutral set of third parties undertake the responsibility of publicly identifying prosecutors who have committed serious misconduct. The naming of prosecutors will shame bad actors, provide a valuable pedagogical lesson for junior prosecutors, and signal to trial judges that certain prosecutors must be monitored more closely to avoid future misconduct.


Under Canada's Disaster Financial Assistance Arrangements (DFAA), the federal government can provide provinces with funds for emergency response and recovery in the event of a natural disaster. This assistance has historically been provided on an ad hoc basis. In recent years, the amount of DFAA assistance has significantly increased without any auditing to determine how effective and efficient these expenditures are in offsetting economic losses due to natural disasters. The goal of this paper is to examine the implications of natural disaster compensation and assistance programs for economic efficiency. A framework is developed to determine if government assistance expenditures have offset economic losses to a specific industry using a case study of the 1998 ice storm and the eastern Ontario maple syrup industry. Projections of damage recovery are used to measure the economic impact of the storm, and a comparison is then drawn between the change in producers' welfare and government assistance. The implications of the findings for the case study and for future natural disaster assistance programs in Canada are discussed.


Substance use among pregnant women is a perennial problem in the Western Cape Province of South Africa. There are many influential elements related with substance use among women of childbearing-age. Factors associated with substance use during pregnancy were explored using qualitative research approach and bio-ecological theoretical framework was utilised to guide the study. Participants were selected using purposive sampling. Participants accessed from the Department of Social Development who met the inclusion criteria of the study were interviewed using semi structured interviews. Participants were referred for psychological intervention during the interview if deemed necessary. Braun and Clarke's six phases of thematic analysis were used to analyse the data. The study adhered to ethical measures for the participants' protection. Participants had been knowledgeable about the study earlier than the initiation of the interviews and the important points of their voluntary participation had been explained. The key findings from this study illustrate that social factors, individual area and romantic relationship are the major contributing factors to substance use among pregnant ladies in this sample. Recommendations arising from the study encompass that the stakeholders, rehabilitation centers, Department of Health and future researchers ought to act proactively against substance use all through pregnancy. Keywords—Bio-ecological factors, pregnancy risk awareness, antenatal care, substance use.


Plant genetic resources are crucial for world agriculture, food security and the global economy. They are vital for the pharmaceutical industry and are important assests for developing countries rich in biodiversity. The patents and intellectual property rights (IPRs) associated with the development of new products are critical to trade in these resources. The relevant international agreements are discussed : the Convention on Biological Diversity (CBD); the World Trade Organization's TRIPS Agreement; and the Convention of the International Union for the Protection of New Varieties of Plants (UPOV). The author provides the first full-scale account of how to integrate the requirements of the CBD into an equitable global IPR regime, taking into account ethical concerns, environmental and social impacts, technology transfer and traditional knowledge


HIGH RATE SPACE TIME CODE WITH LINEAR DECODING COMPLEXITY FOR MULTIPLE TRANSMITTING ANTENNAS by Amir Laufer The multipath nature of the wireless channel, results in a superposition of the signals of each path at the receiver. This can lead to either constructive or destructive interference. Strong destructive interference is frequently referred to as deep fade and may result in temporary failure of communication due to the severe drop in the channel's signal-to-noise ratio (SNR). To avoid this situation, signal diversity might be introduced. When having more than one antenna at the transmitter and / or receiver, forming a Multiple-Input Multiple-Output (MIMO) channel, spatial diversity can be employed to overcome the fading problem. Space time block codes (STBC) have been shown to be used well with the MIMO channel. Each type of STBC is designed to optimize a different criteria such as rate and diversity, while other characteristics of the code are its error performance and decoding computational complexity. The Orthogonal STBC (OSTBC) family of codes is known to achieve full diversity as well as very simple implementation of the Maximum Likelihood (ML) decoder. However, it was proven that, with complex symbol constellation one cannot achieve a full rate code when the number of transmitting antennas is larger than two. Quasi OSTBC are codes with full rate but with the penalty of more complex decoding, and in general does not achieve full diversity. In this work, new techniques for OSTBC transmission / decoding are explored, such that a full rate code can be transmitted and decoded with linear complexity. The Row Elimination Method (REM) for OSTBC transmission is introduced, which basically involves the transmission of only part of the original OSTBC codeword, resulting in a full rate code termed Semi-Orthogonal STBC (SSTBC). Novel decoding scheme is presented, such that the SSTBC decoding computational complexity remains linear although the transmitted codeword is not orthogonal anymore. A new OSTBC, that complies with the new scheme's requirements, is presented for any number of transmit antennas. The performance of the new scheme is studied under various settings, such as system with limited feedback and multiple antennas at the receiver. The general decoding techniques presented for STBC, assume perfect channel knowledge at the receiver. It was shown, that the performance of any STBC system is severely degraded due to partial channel state information, results from imperfect channel estimation. To minimize the performance loss, one may lengthen the training sequences used for the channel estimation which, inevitably, results in some rate loss. In addition, complex decoding schemes can be used at the receiver to jointly decode the data while enhancing the channel estimation. It is suggested in this work to apply adaptive techniques to mitigate the performance loss without the penalty of additional rate loss or complex decoding. Namely, the bootstrap algorithm is used to further refine the received signals, resulting in better effective rate and performance in the presence of channel estimation errors. Modified implementations for the bootstrap's weights calculation method are also presented, to improve the convergence rate of the algorithm, as well as to maintain a very low computational burden. HIGH RATE SPACE TIME CODE WITH LINEAR DECODING COMPLEXITY FOR MULTIPLE TRANSMITTING ANTENNAS


Schedulers for cloud computing determine on which processing resource jobs of a workflow should be allocated. In hybrid clouds, jobs can be allocated on either a private cloud or a public cloud on a pay per use basis. The capacity of the communication channels connecting these two types of resources impacts the makespan and the cost of workflow execution. This article introduces the scheduling problem in hybrid clouds presenting the main characteristics to be considered when scheduling workflows, as well as a brief survey of some of the scheduling algorithms used in these systems. To assess the influence of communication channels on job allocation, we compare and evaluate the impact of the available bandwidth on the performance of some of the scheduling algorithms.


His fields are empty, so Tom Farmer is looking for all the farmyard animals. He's in for a big surprise when he finds them! What will he do to sort them out? Die-cut holes in each page hold clues to what follows, with lots of scope for imitation and expression. Bouncy illustrations, innovative die cutting and popular rhymes make Books with Holes a must for every child. Available in three formats, suitable for babies, toddlers, pre-schoolers and the nursery or classroom.


Introduction Delirium is a severe neuropsychiatric syndrome of rapid onset, commonly precipitated by acute illness. It is common in older people in the emergency department (ED) and acute hospital, but greatly under-recognised in these and other settings. Delirium and other forms of cognitive impairment, particularly dementia, commonly coexist. There is a need for a rapid delirium screening tool that can be administered by a range of professional-level healthcare staff to patients with sensory or functional impairments in a busy clinical environment, which also incorporates general cognitive assessment. We developed the 4 'A's Test (4AT) for this purpose. This study's primary objective is to validate the 4AT against a reference standard. Secondary objectives include (1) comparing the 4AT with another widely used test (the Confusion Assessment Method (CAM)); (2) determining if the 4AT is sensitive to general cognitive impairment; (3) assessing if 4AT scores predict outcomes, including (4) a health economic analysis. Methods and analysis 900 patients aged 70 or over in EDs or acute general medical wards will be recruited in three sites (Edinburgh, Bradford and Sheffield) over 18 months. Each patient will undergo a reference standard delirium assessment and will be randomised to assessment with either the 4AT or the CAM. At 12 weeks, outcomes (length of stay, institutionalisation and mortality) and resource utilisation will be collected by a questionnaire and via the electronic patient record. Ethics and dissemination Ethical approval was granted in Scotland and England. The study involves administering tests commonly used in clinical practice. The main ethical issues are the essential recruitment of people without capacity. Dissemination is planned via publication in high impact journals, presentation at conferences, social media and the website www.the4AT.com. Trial registration number ISRCTN53388093; Pre-results.


IMPORTANCE
Evidence supporting the choice of intravenous colloid vs crystalloid solutions for management of hypovolemic shock remains unclear.

OBJECTIVE
To test whether use of colloids compared with crystalloids for fluid resuscitation alters mortality in patients admitted to the intensive care unit (ICU) with hypovolemic shock.

DESIGN, SETTING, AND PARTICIPANTS
A multicenter, randomized clinical trial stratified by case mix (sepsis, trauma, or hypovolemic shock without sepsis or trauma). Therapy in the Colloids Versus Crystalloids for the Resuscitation of the Critically Ill (CRISTAL) trial was open label but outcome assessment was blinded to treatment assignment. Recruitment began in February 2003 and ended in August 2012 of 2857 sequential ICU patients treated at 57 ICUs in France, Belgium, North Africa, and Canada; follow-up ended in November 2012.

INTERVENTIONS
Colloids (n = 1414; gelatins, dextrans, hydroxyethyl starches, or 4% or 20% of albumin) or crystalloids (n = 1443; isotonic or hypertonic saline or Ringer lactate solution) for all fluid interventions other than fluid maintenance throughout the ICU stay.

MAIN OUTCOMES AND MEASURES
The primary outcome was death within 28 days. Secondary outcomes included 90-day mortality; and days alive and not receiving renal replacement therapy, mechanical ventilation, or vasopressor therapy.

RESULTS
Within 28 days, there were 359 deaths (25.4%) in colloids group vs 390 deaths (27.0%) in crystalloids group (relative risk [RR], 0.96 [95% CI, 0.88 to 1.04]; P = .26). Within 90 days, there were 434 deaths (30.7%) in colloids group vs 493 deaths (34.2%) in crystalloids group (RR, 0.92 [95% CI, 0.86 to 0.99]; P = .03). Renal replacement therapy was used in 156 (11.0%) in colloids group vs 181 (12.5%) in crystalloids group (RR, 0.93 [95% CI, 0.83 to 1.03]; P = .19). There were more days alive without mechanical ventilation in the colloids group vs the crystalloids group by 7 days (mean: 2.1 vs 1.8 days, respectively; mean difference, 0.30 [95% CI, 0.09 to 0.48] days; P = .01) and by 28 days (mean: 14.6 vs 13.5 days; mean difference, 1.10 [95% CI, 0.14 to 2.06] days; P = .01) and alive without vasopressor therapy by 7 days (mean: 5.0 vs 4.7 days; mean difference, 0.30 [95% CI, -0.03 to 0.50] days; P = .04) and by 28 days (mean: 16.2 vs 15.2 days; mean difference, 1.04 [95% CI, -0.04 to 2.10] days; P = .03).

CONCLUSIONS AND RELEVANCE
Among ICU patients with hypovolemia, the use of colloids vs crystalloids did not result in a significant difference in 28-day mortality. Although 90-day mortality was lower among patients receiving colloids, this finding should be considered exploratory and requires further study before reaching conclusions about efficacy.

TRIAL REGISTRATION
clinicaltrials.gov Identifier: NCT00318942.


During the nineteenth century, the bicycle evoked an exciting new world in which even a poor person could travel afar and at will. But was the "mechanical horse" truly destined to usher in a new era of road travel or would it remain merely a plaything for dandies and schoolboys? In Bicycle: The History (named by Outside magazine as the #1 book on bicycles), David Herlihy recounts the saga of this far-reaching invention and the passions it aroused. The pioneer racer James Moore insisted the bicycle would become "as common as umbrellas." Mark Twain was more skeptical, enjoining his readers to "get a bicycle. You will not regret it-if you live." Because we live in an age of cross-country bicycle racing and high-tech mountain bikes, we may overlook the decades of development and ingenuity that transformed the basic concept of human-powered transportation into a marvel of engineering. This lively and engrossing history retraces the extraordinary story of the bicycle-a history of disputed patents, brilliant inventions, and missed opportunities. Herlihy shows us why the bicycle captured the public's imagination and the myriad ways in which it reshaped our world.


With the emergence of digital technologies in visual culture, much concern has been expressed about its potential for manipulation at the expense of the conventional premise that art in some way represents reality. The digital turn elicits in film theory a fear of the loss of the index, a loss that renders the image's relation with the Real even more tenuous. Scan Cubitt, for instance, considers the digital sublime to offer "no guarantee of escape from ideology but rather a refusal of the social, the only possible ground of ideological work, conflict, interpretation, dialectic and history." (1) Such a statement, however, is the result of a slippage between two different discourses. The degree to which digital technologies allow for the manipulation of images, and as it were, the creation of images that do not exist in real life, taps into a conversation about the potentials and limitations of representation. Cubitt's concerns arise within the realm of such a discussion, although the implications of digital technologies for the ontological status of the index taps into a rather different discourse. Theorists such as SaskiaSassen, Philip Rosen, and Thomas Elsaesser in different ways articulate more complex views that subvert Cubitt's conception of the digital sublime and shows how the digital turn might present opportunities for materializing the political potentials of the digitized and the virtual. Employing these theoretical premises about the political potentials of the digital, this article identifies the resurgence of the political in two rather different digital media practices, and examines their potential for theorizing the political documentary. Some time ago, Jane Gaines mused about the "strange association of apolitical films with social change and radical politics," and wondered about "the significance, if any, of the reception of political documentaries in the absence of a struggle." (2) As this article hopes to show, the various and effective uses of digital technologies to galvanize the body into political action have implications for the ways in which we define, and conceive of, the documentary. Contrary to the fear that the digital displaces the significance of the physical, enfleshed, and the social, there are convincing arguments that conclude that the loss of the index might not lead to such dire consequences. Sassen cites the example of the global financial markets and insists that these electronic financial instruments require large varieties and quantities of conventional structures and that "much, although not all, of what we think of cyberspace would lack any meaning or referents if we were to exclude the world outside of cyberspace." (3) Acknowledging the transpository nature of digital objects. Sassen refers to the interface between the human and computer "layers" and the material conditions necessary for such interface. And indeed, the current global financial meltdown reminds us that abstract capital can result in very material consequences for the real economy. Using the example of satellite surveillance, Rosen similarly argues that "the 'purity' of 'pure data' cannot mean the obliteration of referential origins, for without referential entities or events pre-existing the data itself, the data would have no informational value as surveillance." (4) Moreover, Rosen notes, "digital imaging as such does not absolutely rule out a profilmic origin, for the digital has means of incorporating the indexical." (5) [ILLUSTRATION OMITTED] Despite the clear interrelation of the digital with the material, however, the fantasy (or horror, depending on one's perspective) of the loss of the index toward an attainment of the "digital sublime" persists. As Elsaesser insists, it is somewhat unfair to blame the digital signal "for the death of our notion of what is real or true." (6) Elsaesser furthers this assertion by using the issue of the trustworthiness of network news as an example, arguing that television news' fidelity to real events depends more on the political context and network-viewer contract than the loss of the indexical sign to the digital. …


Paths of online users towards a purchase event (conversion) can be very complex, and guiding them through their journey is an integral part of online advertising. Studies in marketing indicate that a conversion event is typically preceded by one or more purchase funnel stages, viz., unaware, aware, interest, consideration, and intent. Intuitively, some online activities, including web searches, site visits and ad interactions, can serve as markers for the user's funnel stage. Identifying such markers can potentially refine conversion prediction, guide the design of ad creatives (text and images), and lead to higher ad effectiveness. We explore this hypothesis through a set of experiments designed for two tasks: (i) conversion prediction given a user's activity trail, and (ii) funnel stage specific targeting and creatives. To address challenges in the two tasks, we propose an attention based recurrent neural network (RNN) which ingests a user activity trail, and predicts the user's conversion probability along with attention weights for each activity (analogous to its position in the funnel). Specifically, we propose novel attention mechanisms, which maintain a global weight for each activity across all user trails, and also indicate the activity's funnel stage. Use of the proposed attention mechanisms for the first task of conversion prediction shows significant AUC lifts of 0.9% on a public dataset (RecSys 2015 challenge), and up to 3.6% on three proprietary datasets from a major advertising platform (Yahoo Gemini). To address the second task, the activity weights from the proposed mechanisms are used to automatically assign users to funnel stages via a scalable scoring method. Offline evaluation shows that such activity weights are more aligned with editorially tagged activity-funnel stages compared to weights from existing attention mechanisms and simpler conversion models like logistic regression. In addition, results of online ad campaigns in Yahoo Gemini with funnel specific user targeting and ad creatives show strong performance lifts further validating the connection across online activities, purchase funnel stages, stage-specific custom creatives, and conversions.


With stunning new design and layout and the most up-to-date travel information, the market's most indispensable phrasebook has been reinvented, and is better than ever. Gem Japanese will give you the right word at the right time -- every time. In all of the most common travel situations, you need the reassurance that you can communicate with ease. A reliable, portable and easy-to-use phrasebook is a travel essential, and now with the completely re-designed Collins Gem Japanese, the right word will always be at your fingertips. With a whole new look inside and out that includes a new cover and easy-to-navigate layout, it is now simpler than ever to use the Japanese language effectively and with confidence. This indispensable language guide covers the topics and phrases that crop up everyday on holiday, from finding a hotel to choosing wine. Includes: / Fully updated travel information / Travel tips / 3000 word dictionary / Comprehensive menu decoder / Grammar and pronunciation sections / "Face to face" sections With the help of Gem Japanese you will never be lost for words in Japan again.


Background: Laparoscopic cholecystectomy is accepted as the standard procedure for gallstone disease. Laparoscopic cholecystectomy is associated with more biliary, vascular, and visceral complications when compared with open cholecystectomy. The identification of Rouviere's sulcus is an additional strategy that can be used to prevent bile duct injuries. The aim of this study was to determine the frequency and the type of Rouviere's sulcus. Materials & Methods: This was a prospective descriptive study of 402 patients who presented with symptomatic gallstone disease and underwent laparoscopic cholecystectomy. Rouviere's sulcus was looked for before starting dissection. The frequency and the type of the sulcus were recorded. Results: Out 402 patients who underwent laparoscopic cholecystectomy, 284 (70.6%) patients were female and 118 (29.4%) patients were male, with a mean age of 48.4 (range 17-68 years), 221 patients (54.9%) were found to have open sulcus, fused type was found in 98 (24.4%) of patients, and not present in 83 (20.7%) of patients. Conclusion: The easy recognition of Rouviere's sulcus makes it a dependable landmark during severe acute inflammation. By dissecting ventral to Rouviere's sulcus, the surgeon ensures that they are operating away from the danger area.


In recent decades, many strengthening interventions on masonry elements were performed by using fiber reinforced polymers (FRPs). These advanced materials proved to be effective to increase the load-carrying capacity of masonry elements and to improve their structural behavior, avoiding the most critical failure modes. Despite the advantages of this technique compared to more traditional methods, FRP systems have disadvantages related to their low resistance to high temperatures, impossibility of application on wet surfaces, low permeability, and poor compatibility with masonry supports. Therefore, composite materials made of a fiber textile embedded in an inorganic matrix were recently proposed as alternatives to FRPs for strengthening historic masonry constructions. These composite materials are easier to install, have higher resistance to high temperatures, and permit higher vapor permeability than FRPs. The inorganic matrix is frequently a cement-based mortar, and the composite materials made of a fiber textile embedded in a cement-based mortar are usually identified as FRCM (fabric reinforced cementitious matrix) composites. More recently, the use of natural lime mortar as an inorganic matrix has been proposed as an alternative to cement-based mortars when historic compatibility with the substrate is strictly required, as in case of restoration of historic buildings. In this paper, the effectiveness of a fabric made of basalt fibers embedded in lime mortar matrix (Basalt-FRLM) for the strengthening of masonry arches is investigated. An experimental investigation was performed on 1:2 scaled brick masonry arches strengthened at the extrados with a layer of Basalt-FRLM and tested under vertical load. The results obtained are compared with previous results obtained by the authors by testing masonry arches strengthened at their extrados with FRCM and FRP composites. This investigation highlights the effectiveness of Basalt-FRLM in increasing load-currying and the displacement capacities of masonry arches. The Basalt-FRLM-strengthened arch exhibited higher displacement capacity when compared to arches strengthened with polymeric and cementitious matrix composites.


[1] An isopycnic coordinate ocean model has been used to investigate the importance of different mechanisms on the Barents Sea climate variability for the period 1948–2006 Observed and simulated time series from the Kola Section are used to evaluate the model, and the model captures both the temperature and its variability. Based on lagged correlations between different climatological time series, it is shown here that heat transport through the Barents Sea Opening and solar heat flux are about equally important to the climate variability in the Barents Sea. The heat transport has greater potential of predictability due to a relatively long time lag. Furthermore, the non-solar and the net heat flux variability is governed by fluctuations in the oceanic heat content. All time series considered important for the Barents Sea climate variability show significant correlation to the North Atlantic Oscillation (NAO) pattern on a decadal time scale. As the associated low pressure system in the Nordic Seas moves eastward from 1948–1977 to 1978–2006, the correlation between NAO and heat transports into the Barents Sea becomes higher.


ASTRI ("Astrofisica con Specchi a Tecnologia Replicante Italiana") is a flagship project of the Italian Ministry of Education, University and Research. Within this framework, INAF is currently developing a wide field of view (9.6 degrees in diameter) end-to-end prototype of the CTA small-size telescope (SST), devoted to the investigation of the energy range from a fraction of TeV up to tens of TeVs, and scheduled to start data acquisition in 2014. For the first time, a dual-mirror Schwarzschild-Couder optical design will be adopted on a Cherenkov telescope, in order to obtain a compact optical configuration. A second challenging, but innovative technical solution consists of a modular focal surface camera based on Silicon photo-multipliers with a logical pixel size of 6.2mm x 6.2mm. Here we describe the current status of the project, the expected performance, and its possible evolution in terms of an SST mini-array. This CTA-SST precursor, composed of a few SSTs and developed in collaboration with CTA international partners, could not only peruse the technological solutions adopted by ASTRI, but also address a few scientific test cases that are discussed in detail.


Forest bathing, i.e. spending time in a forest to walk, view and breathe in a forest, can alleviate the mental depression of visitors, but the tree-species-specific effect of this function by the urban forest is unknown. In this study, sixty-nine university students (aged 19-22, male ratio: 38%) were recruited as participants to visit urban forests dominated by birch (Betula platyphylla Suk.), maple (Acer triflorum Komarov) and oak (Quercus mongolica Fisch. ex Ledeb) trees in a park at the center of Changchun City, Northeast China. In the maple forest only the anxiety from study interest was decreased, while the anxiety from employment pressure was alleviated to the most extent in the birch forest. Participants perceived more anxiety from lesson declined in the oak forest than in the birch forest. Body parameters of weight and age were correlated with the anti-anxiety scores. In the oak forest, female participants can perceive more anxiety alleviation than male participants. For university students, forest bathing in our study can promote their study interest. Forest bathing can be more effective to alleviate the anxiety of young adults with greater weight. The birch forest was recommended to be visited by students to alleviate the pressure of employment worry, and the oak forest was recommended to be visited by girls.


Scholars and international organizations emphasize the role of unions in promoting disability rights. Nonetheless, previous studies showed that unions may underrepresent people with disabilities. The current research aims to contribute to this debate through an empirical examination of collective agreements in Israel. The research shows that although collective agreements in Israel promote disability insurance and job security for people with disabilities, they do not promote accommodations or employability security for workers with disabilities. Moreover, the research shows that coordination between unions and disability organizations is essential to promote the rights of workers with disabilities. Lastly, the research emphasizes the importance of national collective bargaining.


Feeding mechanisms of aquatic vertebrates has been extensively studied in the past, while that of elasmobranchs remains limited. Skates and rays are believed to have evolved from a shark ancestor, thus they represent the most derived group. All skates are dorsoventrally compressed, have a unique jaw suspension type and head skeleton and live in benthic environments. It is unknown whether these derived features of skates have altered the ancestral shark feeding mechanism. Comparing feeding mechanisms in skates and sharks may shed light on morphological transformations that have arisen after the evolutionary split of these two groups. In this study prey capture and manipulation behaviors are compared and contrasted with the white-spotted bamboo shark. Jaw kinematics and buccal pressure during feeding events are investigated using sonomicrometry simultaneously with pressure transducers. Little skates capture prey primarily using biting but sometimes utilize weak suction as well. Pressure in the buccal cavity during prey capture varies around ambient ranging from slightly positive to slightly negative. In contrast bamboo sharks always use strong suction to capture prey with greater subambient buccal pressures. However, both species extensively process prey using strong suction alternately with compression. Such cycles can last several seconds, eventually ending in transport of the prey item. Greater subambient pressure develops in the buccal cavity during manipulation, indicating that skates are capable of generating stronger suction than that used to capture prey. Gape area during capture events is greater than during manipulation. Hyoid area attains similar magnitudes in both capture and manipulation events. Time of mean onset and peak gape and hyoid expansion occurs prior to peak buccal pressure in captures and manipulations. Although both occupy benthic regions of the ocean, prey capture in the two species appears to be quite different while manipulations are similar. Morphological differences in the jaw and hyoid apparatus of sharks and skates may be partly responsible for the functional differences in the generation of suction.


Background: Wilson's disease is a rare inborn disease related to copper storage, leading to liver cirrhosis and neuropsychological deterioration. Clinical data on larger cohorts are limited owing to low disease frequency. Objective and methods: We performed a retrospective analysis of 163 patients with Wilson's disease, examined at the University of Heidelberg, Heidelberg, Germany, to determine clinical presentation, diagnostic course and long-term outcome. Results: Diagnostic criteria for non-caeruloplasmin-bound serum copper, serum caeruloplasmin, 24-h urinary copper excretion, liver copper content, presence of Kayser–Fleischer rings and histological signs of chronic liver damage were reached in 86.6%, 88.2%, 87.1%, 92.7%, 66.3% and 73% of patients, respectively. By analysis of the coding region of ATP7B (except exons 2, 3 and 21), disease-causing mutations were detected in 57% and 29% of patients with Wilson's disease on both chromosomes and on one chromosome, respectively. No mutations were detected in 15% of patients with Wilson's disease. No significant differences were found in clinical parameters or initial presentation between patients grouped according to their mutations. The patients with neurological symptoms were significantly older at the onset of symptoms than patients with hepatitic symptoms (20.2 v 15.5 years of age, p<0.05), and the neurological symptoms were associated with a significantly longer time from onset to diagnosis than hepatic symptoms (44.4 v 14.4 months, p<0.05). After initiating treatment, 76.1% of the patients had a stable or improved course of the disease. Disease progression under treatment was more likely for neuropsychiatric than for hepatic symptoms. Side effects of treatment occurred in 74.4% of patients. Conclusions: Patients with Wilson's disease having predominantly neuropsychiatric symptoms manifest symptoms later, have a longer time delay from onset of symptoms until definitive diagnosis and have a poorer outcome than patients with hepatic symptoms.


The Balkan Endemic Nephropathy (BEN), commonly known as "the dry kidney disease", was observed for the first time in 1957 in Ergheviţa village from Mehedinţi County. Although, the phenomenon was mainly studied by doctors for a period of approximately 50 years, the number of cases increased, but the actual cause of the disease was not discovered yet. Among the mainly incriminated elements, there is to be mentioned the underground water that crosses through the coal deposit located in the Husnicioara mines. It is important to notice the fact that this disease affects only the rural space, most of the effective areas of the disease being concentrated around the urban centres like Drobeta Turnu-Severin, Baia de Aramă, Strehaia and Vânju Mare. The respective rural communities are considered to be truly vulnerable to the poor quality of underground waters. Given the fact that new cases of nephropathy are continuously discovered, one of the hypothesis is that the risk induced by the pollution of underground water layers is significant and that the human communities are highly vulnerable to this element. The present study identifies the actual status regarding the symptoms and the extension of the disease, as well as the economical-social circumstances that favour the occurrence of the cases, representing a strong signal concerning the human communities vulnerable to the pollution of a natural resource that is indispensable to human life – water.


Abstract.
 Research into the relationship between leaf form and climate over the last century has revealed that, in many species, the sizes and shapes of leaf characters exhibit highly structured and predictable patterns of variation in response to the local climate. Several procedures have been developed that quantify covariation between the relative abundance of plant character states and the states of climate variables as a means of estimating paleoclimate parameters. One of the most widely used of these is the Climate Leaf Analysis Multivariate Program (CLAMP). The consistency, accuracy and reliability with which leaf characters can be identified and assigned to CLAMP character-state categories is critical to the accuracy of all CLAMP analyses. Here we report results of a series of performance tests for an image-based, fully automated at the point of use, leaf character scoring system that can be used to generate CLAMP leaf character state data for: leaf bases (acute, cordate and round), leaf apices (acute, attenuate), leaf shapes (ovate, elliptical and obovate), leaf lobing (unlobed, lobed), and leaf aspect ratios (length/width). This image-based system returned jackknifed identification accuracy ratios of between 87% and 100%. These results demonstrate that automated image-based identification systems have the potential to improve paleoenvironmental inferences via the provision of accurate, consistent and rapid CLAMP leaf-character identifications. More generally, our results provide strong support for the feasibility of using fully automated, image-based morphometric procedures to address the general problem of morphological character-state identification.


Managed care pharmacists are involved formally with the interface between the delivery and financing of health care; their work thus entails an accountability for both elements. Interpreted broadly, managed care pharmacists are pharmacists working within the sphere of a health care system, health care purchaser, health insurer, managed care organization, or benefit administration agency. Patients, the pharmacy profession, and society are best served by this broad interpretation, because the interdependency of financing and delivery is inextricably linked to the achievement of good health outcomes. This continuing feature will explore contemporary issues facing managed care pharmacists.


Baked starch/pulp foams were prepared from formulations containing zero to 25 weight percent of processed Alaskan fish by-products that consisted mostly of salmon heads, pollock heads, and pollock frames (bones and associated remains produced in the filleting operation). Fish by-products thermoformed well along with starch and pulp fiber, and the foam product (panels) exhibited useful mechanical properties. Foams with all three fish by-products, ranging between 10 and 15 wt%, showed the highest flexural modulus (500-770 Mpa). Above 20% fiber content, the modulus dropped considerably in all foam samples. Foam panels with pollock frames had the highest flexural modulus, at about 15% fiber content (770 Mpa). Foams with salmon heads registered the lowest modulus, at 25% concentration. Attempts were also made to cast starch-glycerol-poly (vinyl alcohol) films containing 25% fish by-product (salmon heads). These films showed a tensile strength of 15 Mpa and elongation at break of 78.2%. All foams containing fish by-product degraded well in compost at ambient temperature (24oC), loosing roughly between 75-80% of their weight within 7 weeks. The films degraded at a much higher rate initially. When left in water, foams prepared without fish by-product absorbed water much more quickly and deteriorated faster, whereas, water absorption in foams with fish by-product was initially delayed and/or slowed for about 24 h. After this period, water absorption was rapid.


Abstract The alpine treeline in northern Fennoscandia is composed primarily of mountain birch (Betula pubescens ssp. czerepanovii), a deciduous tree that experiences episodic defoliation due to outbreaks of the autumnal moth (Epirrita autumnata) and winter moth (Operophtera brumata). Here, we use an extensive dendroecological data set to reconstruct historic defoliating outbreaks and relate them to climatic conditions. Our data are from 25 sites in eight valleys in northern Sweden. We used the computer program OUTBREAK to reconstruct moth outbreaks. The reconstructed outbreak record matches the historical record well. There is a significant, but weak relationship between the outbreak severity and temperatures in February, April, July, and August of the outbreak year. Temperatures in the previous May and November were also positively correlated with outbreak severity. For seasonally aggregated temperatures, only autumn temperatures are correlated with outbreak severity. There was no significant correlation between NAO index and outbreak severity. A spatiotemporal semivariogram analysis showed that sites within approximately 100 km of each other show similar patterns in outbreak severity. Our analyses suggest that moths are affected by climatic variations. The influence of climate on outbreaks is weak because background climatic conditions alone cannot induce an outbreak. Outbreaks also depend on nonclimatic factors, such as tree age, and the outbreak status of neighboring areas.


This bibliography contains all second-person texts and criticism that I have been able to verify personally. In some cases I have included items on the basis of reliable commentary by others. I would like to thank all colleagues who have helped me in the process of compiling this bibliography. Pride of place on that list goes to Irene Kacandes, whom I met at Harvard in 1987-88 while she was writing her dissertation on second-person fiction and who generously supplied me with an initial list of texts and criticism. Since then I have profited from the kindness and generosity of Isabella de Campo, Werner Helmich, Uri Margolin, Reingard M. Nischik, Brian Richardson, Dennis Schofield, and Ursula Wiest. To them all I tender a most grateful thank-you for their selfless cooperation. Special thanks go to Markus Schaffauer for help with the Spanish texts quoted by Gnutzmann. The bibliography has four different sections: A. a list of those second-person texts that meet my requirements as explained in my "Introduction" to the special issue of Style on second-person narrative, Volume 28, no. 3 (Fall 1994). The second-person pronoun refers to a fictional protagonist; B. a list of texts noted in the literature as being second-person texts but that do not correspond to my definition. I mention these for fairness sake and in order to save others the task of reading these works, believing them to be texts that I had overlooked or been unaware of only to be disappointed in the expectation of these texts' belonging to group A; C. a very short list of a few films with second-person voice-over that I have found mentioned or seen myself. This is a very incomplete section, but will (I hope) serve as a stimulant for further research; D. a list of criticism on the second person and address in general, on second-person narrative, and on second-person uses in poetry; Works of poetry have not been included in section A of the bibliography, but some of the contexts in which the second person shows up in poetry are incipiently narrative. It is for this reason that I have included discussions of the use of the second person in poetry in section D. Annotations to the entries in section A contain the following information: (1) the extent of the use of the second-person pronoun in reference to the protagonist (information provided only for novels); (2) remarks on the use of tenses or other pronouns in these works ("past tense" referring to the use of the past tense in reference to narrative events of the story, "present-tense narration" to the use of the present tense for plot events); (3) remarks on the presence or absence of a narrator figure or a prominent address function. Comments on Spanish texts for which I had no access to a translation rely on help I have received from Markus Schaffauer (Freiburg) who kindly cooperated with me in the last stages of compiling this bibliography. My annotations describe the impression I gained from the description that I received of the use of the second person, and they may therefore be incorrect. I hope that this issue will inspire many Spanish scholars to dedicate themselves to a more reliable analysis. Out of fairness to other approaches and models no categorization is provided in terms of my own typology. Annotations are kept to a minimum. For this reason texts that are discussed in detail in the essays that appeared in the special issue of Style on second-person narrative (Volume 28, no. 3, Fall 1993) are not given any annotations. Lacunae in this bibliography are as follows. Some works that are supposedly second-person narratives proved to be untraceable to me from Europe. Where I believe that these texts are very difficult to find, I have included them nevertheless in the hope that somebody else may be luckier than I. I have, however, excluded much literature that was mentioned to me and about whose quality as second-person texts I have remained doubtful. …


From the Battle of the Boyne in 1690 to the Downing Street Declaration of 1993, Britain and Ireland have been in mortal conflict over the sovereignty of the Emerald Isle. In this text, Tony Geraghty writes a full account of the tragic three-hundred-year war, tracing the path to today's weary peace. It is a history of England's ruthless aggression against her small Catholic neighbour and that tiny island's utter determination to oust the bullying intruder.


The accuracy of a survey is directly affected by how the survey is presented, how the questions are worded, and what the format is for responses. In addition, survey methods continue to develop at an accelerating rate to keep step with technological demands. Consequently, research on survey methods themselves is essential to ensuring accurate data. Survey Measurements presents the most up to date findings in this field. Exploring the effects of survey question format and survey type on data quality as well as developments in the treatment of missing data, an international collection of contributors addresses such key topics as motivated misreporting; audio-recording of open-ended questions; framing effects; multitrait-multimethod matrix modeling; web, mobile web, and mixed-mode research; experience sampling; estimates of change; and multiple imputation. This book will be a vital resource for teachers and students of survey methodology, advanced data analysis, applied survey research, and a variety of disciplines including the social sciences, public health research, epidemiology, and psychology.


Controlled bleaching of the iodine dichromophore from iodine-polyvinyl alcohol polarizers has been demonstrated to result in a dramatic increase in transmission. Internal transmission of 95% for linearly polarized light has been observed in the spectral range of 5000–6000 A. Degradation of polarizer extinction is most severe at shorter wavelengths; however, the transmittance for the crossed polarization remains <0.1% through much of the visible spectrum.


Two types of erosion controls that have had their own successes separately - cobble beach nourishment and a modular previous sill - were deployed in a successful combination to protect a seriously eroded coast on Lake Michigan north of Chicago. In the first combination of its kind, cobble nourishment was used to create a new perched beach where no natural beach was left, and the modular pervious sill (Surgebreaker offshore reef) was installed as a new shoreline. The cobble beach-sill system was designed to protect bluff toes that were being damaged by waves that overtopped and scoured a deteriorating sheetpile bulkhead at water's edge. Wave attack in the area has been increasing, with normally high-energy storm surges and century-high and still rising lake levels. Bluff toe damage has stopped. The perched cobble beach appears suitably stable, with the protective sill, and has recent system design adjustments that should increase stability. The sill appears responsible for substantial shoaling, from sill toe to at least 100 ft. offshore.


Accumulating evidence indicates that the gut microbiota affects colorectal cancer development, but previous studies have varied in population, technical methods, and associations with cancer. Understanding these variations is needed for comparisons and for potential pooling across studies. Therefore, we performed whole-genome shotgun sequencing on fecal samples from 52 pre-treatment colorectal cancer cases and 52 matched controls from Washington, DC. We compared findings from a previously published 16S rRNA study to the metagenomics-derived taxonomy within the same population. In addition, metagenome-predicted genes, modules, and pathways in the Washington, DC cases and controls were compared to cases and controls recruited in France whose specimens were processed using the same platform. Associations between the presence of fecal Fusobacteria, Fusobacterium, and Porphyromonas with colorectal cancer detected by 16S rRNA were reproduced by metagenomics, whereas higher relative abundance of Clostridia in cancer cases based on 16S rRNA was merely borderline based on metagenomics. This demonstrated that within the same sample set, most, but not all taxonomic associations were seen with both methods. Considering significant cancer associations with the relative abundance of genes, modules, and pathways in a recently published French metagenomics dataset, statistically significant associations in the Washington, DC population were detected for four out of 10 genes, three out of nine modules, and seven out of 17 pathways. In total, colorectal cancer status in the Washington, DC study was associated with 39% of the metagenome-predicted genes, modules, and pathways identified in the French study. More within and between population comparisons are needed to identify sources of variation and disease associations that can be reproduced despite these variations. Future studies should have larger sample sizes or pool data across studies to have sufficient power to detect associations that are reproducible and significant after correction for multiple testing.


Inspired by nature, continuum robots show their potential in human-centered environments due to the compliant-to-obstacle features and dexterous mobility. However, there are few such robots successfully implemented outside the laboratory so far. One reason is believed to be due to the real time control challenge for soft robots, which require a highly efficient, highly accurate dynamic model. This paper presents a new systematic methodology to formulate the dynamics of constant curvature continuum robots. The new approach builds on several new techniques: 1) using the virtual work principle to formulate the equation of motion, 2) using specifically selected kinematic representations to separate integral variables from the non-integral variables, and 3) using vector representations to put the integral in a compact form. By doing so, the hard-to-solve integrals are evaluated analytically in advance and the accurate inverse dynamics are established accordingly. Numerical simulations are conducted to evaluate the performances of the newly proposed model.


A major shortcoming of empirical scoring functions for protein-ligand complexes is the low degree of correlation between predicted and experimental binding affinities, as frequently observed not only for large and diverse data sets but also for SAR series of individual targets. Improvements can be envisaged by developing new descriptors, employing larger training sets of higher quality, and resorting to more sophisticated regression methods. Herein, we describe the use of SFCscore descriptors to develop an improved scoring function by means of a PDBbind training set of 1005 complexes in combination with random forest for regression. This provided SFCscore(RF) as a new scoring function with significantly improved performance on the PDBbind and CSAR-NRC HiQ benchmarks in comparison to previously developed SFCscore functions. A leave-cluster-out cross-validation and performance in the CSAR 2012 scoring exercise point out remaining limitations but also directions for further improvements of SFCscore(RF) and empirical scoring functions in general.


Learning communities are small pre-selected student groups based on a common interest with a variety of goals related to student outcomes. Previous research has shown robust effects of learning community participation on student success outcomes, but little is known about the mechanisms which may mediate these effects. The current study analyzed two years of data on a large sample of first-year and transfer students using mediated regression techniques and logistic regression to explore the mechanism by which learning communities affect self reported student behaviors. Results showed that being in a learning community leads to positive academic and social attitudes which lead to increased academic and social behaviors respectively. Results shed light on the mechanism by which learning communities affect student outcomes.


The hypercatabolism after massive pediatric burns has been effectively treated with recombinant human growth hormone, an anabolic agent that stimulates protein synthesis and abrogates growth arrest. While experimental studies have shown increased potential for fibrosis induced by growth hormone therapy, adverse effects on human scars have not been investigated. Our aim was to evaluate hypertrophic scar formation in 62 patients randomized to receive injections of 0.05 mg/kg/day of recombinant human growth hormone or placebo, from discharge until 1 year after burn. Scar scales were used to evaluate scar‐severity at discharge, 6, 9, 12, and 18–24 months after burn, by three observers blinded to treatment. Computer‐assisted planimetry allowed quantification of percentage of hypertrophic scar formation. Types I and III collagens were localized and quantified in scars and normal skin of patients from both groups, using immunohistochemistry with confocal laser microscopy analysis. Insulin‐like growth factor‐1 blood levels helped assess compliance. Statistical analysis showed that scar hypertrophy significantly increased from 6 to 12 months after injury in both groups, while decreasing at 18–24 months postburn. Types I and III collagens were statistically increased in the reticular layer of scars from both groups when compared to paired normal skin. Insulin‐like growth factor‐1 was significantly increased in the recombinant human growth factor‐treated group. No differences were seen when recombinant human growth factor and control groups were compared using the scar scales, planimetry, or immunohistochemistry. We concluded that recombinant human growth hormone therapy did not adversely affect scar formation and should not contraindicate the administration of recombinant human growth hormone as a therapeutic approach to severely burned children.


Introduction: Hot flush is the most common problem in menopausal women. One of the alternative treatments is phytostrogens. So this study aimed to examine the effects of fenugreek and flaxseeds on frequency and severity of hot flush. Methods: In this randomized controlled clinical trials the sample population was 60 women with hot flush who referred to urbon heath centers. They divided into two groups. For the first group 6g fenugreek and for the other group 25g flaxseeds were prescribed for four continuous weeks. The inclusion criteria were on menses in lately 12 months, normal blood pressure, no use of antidepressants and estrogen and progesterone hormones in lately 6 weeks, no anticoagulant, non-steroidal antiinflammatory drugs like brufen, no asthma and allergy. The exclusion criteria were no correct use of herbals, allergy to drugs, and change the life place. The severity and frequency of hot flush were examined in fourth and eighth weeks. Results: The severity of hot flush in flax group was (1.163,1.614) 1.389 and in fenugreek group it was (1.541,1.992) 1.767 in eighth week. Frequency mean of hot flush in fenugreek was (0.926, 1.373) 1.149 and for flaxseeds it was (1.102, 1.542)1.322 in eighth week. Conclusions: Fenugreek and flaxseeds decreased the severity and frequency of hot flush. But for herbal supplements it needs the additional investigations and samples in the other regions.


Silica nanoparticles and porous microparticles have been successfully functionalized with a monolayer of DTPA-derived ligands. The ligand grafting is chemically robust and does not appreciably influence the morphology or the structure of the material. The produced particles exhibit quick kinetics and high capacity for REE adsorption. The feasibility of using the DTPA-functionalized microparticles for chromatographic separation of rare earth elements has been investigated for different sample concentrations, elution modes, eluent concentrations, eluent flow rates, and column temperatures. Good separation of the La(III), Ce(III), Pr(III), Nd(III), and Dy(III) ions was achieved using HNO3 as eluent using a linear concentration gradient from 0 to 0.15 M over 55 min. The long-term performance of the functionalized column has been verified, with very little deterioration recorded over more than 50 experiments. The results of this study demonstrate the potential for using DTPA-functionalized silica particles in ...


Estimates of terrestrial carbon isotope discrimination are useful to quantify the terrestrial carbon sink. Carbon isotope discrimination by terrestrial ecosystems may vary on seasonal and interannual time frames, because it is affected by processes (e.g. photosynthesis, stomatal conductance, and respiration) that respond to variable environmental conditions (e.g. air humidity, temperature, light). In this study, we report simulations of the temporal variability of canopy‐scale C3 photosynthetic carbon isotope discrimination obtained with an ecophysiologically based model (ISOLSM) designed for inclusion in global models. ISOLSM was driven by half‐hourly meteorology, and parameterized with eddy covariance measurements of carbon and energy fluxes and foliar carbon isotope ratios from a pine forest in Metolius (OR). Comparing simulated carbon and energy fluxes with observations provided a range of parameter values that optimized the simulated fluxes. We found that the sensitivity of photosynthetic carbon isotope discrimination to the slope of the stomatal conductance equation (m, Ball–Berry constant) provided an additional constraint to the model, reducing the wide parameter space obtained from the fluxes alone. We selected values of m that resulted in similar simulated long‐term discrimination as foliar isotope ratios measured at the site. The model was tested with 13C measurements of ecosystem (δR) and foliar (δf) respiration. The daily variability of simulated 13C values of assimilated carbon (δA) was similar to that of observed δf, and higher than that of observed and simulated δR. We also found similar relationships between environmental factors (i.e. vapor pressure deficit) and simulated δR as measured in ecosystem surveys of δR. Therefore, ISOLSM reasonably simulated the short‐term variability of δA controlled by atmospheric conditions at the canopy scale, which can be useful to estimate the variability of terrestrial isotope discrimination. Our study also shows that including the capacity to simulate carbon isotope discrimination, together with simple ecosystem isotope measurements, can provide a useful constraint to land surface and carbon balance models.


This article presents findings from the first year of the Harbingers research project started in 2015. The project is a 3‐year longitudinal study of early career researchers (ECRs) to ascertain their current and changing habits with regard to information searching, use, sharing, and publication. The study recruited 116 researchers from seven countries (UK, USA, China, France, Malaysia, Poland, and Spain) and performed in‐depth interviews by telephone, Skype, or face‐to‐face to discover behaviours and opinions. This paper reports on findings regarding discovery and access to scholarly information. Findings confirm the universal popularity of Google/Google Scholar. Library platforms and web‐scale discovery services are largely unmentioned and unnoticed by this user community, although many ECRs pass through them unknowingly on the way to authenticated use of their other preferred sources, such as Web of Science. ECRs are conscious of the benefits of open access in delivering free access to papers. Social media are widely used as a source of discovering scholarly information. ResearchGate is popular and on the rise in all countries surveyed. Smartphones have become a regularly used platform on which to perform quick and occasional searches for scholarly information but are only rarely used for reading full text.


The physiological and pathophysiological importance of intracellular redox active "labile" iron has created a significant need for improved noninvasive diagnostic tools to reliably monitor iron metabolism in living cells. In this context, fluorescent iron-sensitive chemosensors in combination with digital fluorescence spectroscopic methods have proven to be highly sensitive and indispensable tools to determine cellular iron homeostasis. Recently, application of fluorescent iron sensors has led to the identification of a complex sub-cellular iron compartmentation. Cell organelle-specific iron sensors will significantly contribute to enhance fundamental knowledge of cellular iron trafficking, representing a crucial prerequisite for the future development of therapeutic strategies in iron dysregulatory diseases. Here we present physicochemical characterization and functional investigation of a new 3-hydroxypyridin-4-one based fluorescent iron(III) sensor, exclusively monitoring labile iron pools in the endosomal/lysosomal compartments. In vitro studies of the fluorescein labeled probe were carried out in murine bone marrow derived macrophages. Endosomal/lysosomal accumulation of the probe was revealed by confocal microscopy. Flow cytometry analyses demonstrated high sensitivity of the probe towards exogenous alterations of intracellular iron concentrations as well as in response to the chelation potency of iron chelators, clinically approved for treatment of iron-overload related diseases.


We present a computer audition system that can both annotate novel audio tracks with semantically meaningful words and retrieve relevant tracks from a database of unlabeled audio content given a text-based query. We consider the related tasks of content-based audio annotation and retrieval as one supervised multiclass, multilabel problem in which we model the joint probability of acoustic features and words. We collect a data set of 1700 human-generated annotations that describe 500 Western popular music tracks. For each word in a vocabulary, we use this data to train a Gaussian mixture model (GMM) over an audio feature space. We estimate the parameters of the model using the weighted mixture hierarchies expectation maximization algorithm. This algorithm is more scalable to large data sets and produces better density estimates than standard parameter estimation techniques. The quality of the music annotations produced by our system is comparable with the performance of humans on the same task. Our ldquoquery-by-textrdquo system can retrieve appropriate songs for a large number of musically relevant words. We also show that our audition system is general by learning a model that can annotate and retrieve sound effects.


Amino-acid radical enzymes have been studied extensively for 30 years but the experimental barriers to determine the thermodynamic properties of their key radical cofactors are so challenging that only a handful of reports exist in the literature. This is a major drawback when trying to understand the long-range radical transfer and/or catalytic mechanisms of this important family of enzymes. Here this issue is addressed by developing a library of well-structured model proteins specifically designed to study tyrosine and tryptophan radicals. The library is based on a 67-residue three-helix bundle (α3W) and a 117-residue four-helix bundle (α4W). α3W and α4W are single-chain and uniquely structured proteins. They are redox inert except for a single radical site (position 32 in α3W and 106 in α4W). Papers I and II describe the design process and the protein characteristics of α4W as well as a voltammetry study of its unique tryptophan. Paper III and V describe two projects based on α3C, which is a Trp-32 to Cys-32 variant of α3W. In Paper III we use α3C to investigate what effect the degree of solvent exposure of the phenolic OH group has on the redox characteristics of tyrosine analogs. We show that the potential of the PhO•/PhOH redox pair is dominated by interactions with the OH group and that the environment around the hydrophobic part of the phenol has no significant impact. In addition, we observe that interactions between the phenolic OH group and the protein matrix can raise the phenol potential by 0.11-0.12 V relative to solution values. The α3C system is extended in Paper V to study quinone redox chemistry. Papers III and V contain protocols to generate the cofactor-containing α3C systems and descriptions of their protein properties. Paper IV describes efforts to redesign α3Y (a Trp-32 to Tyr-32 variant of α3W) to contain an interacting Tyr-32/histidine pair. The aim is to engineer and study the effects of a redox-induced proton acceptor in the Tyr-32 site.


How do vision quests, river locations, and warriors relate to indigenous activism? For the Aguaruna, an ethnic group at the forefront of Peru's Amazonian Movement, incorporating practices and values they define as customary allows them to shape their own experience as modern indigenous subjects. As Shane Greene reveals, this customization centers on the complex articulation of meaningful social practices, cultural logics, and the political economy of specialized production and consumption. Following decades of engagement with and resistance to state-mandated missionary education, land-titling, and international advocacy networks, the Aguaruna have faced numerous constraints in pursuit of their own political projects. Based on first-hand fieldwork, Customizing Indigeneity provides a new theoretical language for the politics of indigeneity. Documenting the dynamic between historical constraints and cultural creativity, this work provides a fresh perspective on indigenous people's agency within evolving structures of inequality, while simultaneously challenging common assumptions about scholarly engagement with marginalized populations.


Over 20 years ago, Eisenberg, Cumberland, and Spinrad (1998; Eisenberg, Spinrad, & Cumberland, 1998) published a landmark article focusing on the socialization of children's emotion and self-regulation, including emotion regulation. In this special issue, our goal was to compile current evidence delineating the impact of emotion-related socialization behaviors (ERSBs) on children's emotion, self-regulation, and developmental outcomes. The work in this issue highlights the processes involved in predicting both parents' ERSBs as well as children's developmental outcomes. Researchers have moved beyond testing individual "pieces" of the socialization of emotion model and now use innovative and sophisticated methods for testing larger models, allowing for more causal interpretations. Special issue contributors focused on longitudinal studies including ERSBs, reviews of the literature extending the original model, and the effectiveness of interventions designed to improve the emotional lives of children and their families. We focus on some of the major themes of the special issue and conclude with recommendations for policies and programs to promote youths' effective emotion-related outcomes. (PsycINFO Database Record (c) 2020 APA, all rights reserved).


Background We compared the anti-depressant and cognitive effects of up to eight sessions of bilateral, brief pulse electroconvulsive therapy (ECT) administered twice (ECT x 2) or three times weekly (ECT x 3), to confirm that ECT x 3 acts more rapidly although the two schedules are equivalent in antidepressant outcome, and to establish whether ECT x 3 is indeed associated with more severe memory impairment. Method Patients with major depression, endogenous subtype were randomly assigned to ECT x 3 or ECT x 2 plus one simulated ECT per week, both up to a maximum of eight real ECT. Depression was evaluated by the Hamilton Depression Scale the day after each treatment and cognitive function by a test battery administered before and after the ECT series and at one month follow-up. Results Assessed categorically or parametrically, there was no significant difference in antidepressant outcome between the two schedules. Rate of response was significantly more rapid with ECT x 3 but was associated with more severe memory impairment. Conclusions Twice weekly administration is an optimum schedule for bilateral ECT unless clinical indications require the more rapid antidepressant effect of three times weekly treatment.