Although agriculture dominates with around 50% area much of Europe- landscape, there is virtually no information on how bats use this farmed environment for foraging. Consequently, little is known about effective conservation measures to compensate potential negative effects of agrarian management practice on the food availability for bats in this habitat. Moreover, there are currently no specific regulatory requirements to include bats in European Union risk assessments for the registration of pesticides since no information about pesticide exposure on this mammal group is available. To evaluate the potential pesticide exposure of bats via ingestion of contaminated insects, information about bat presence and activity in agricultural habitats is required. In order to examine bat activity on a landscape scale it was necessary to establish a suitable survey method. Contrary to capture methods, telemetry, and direct observations, acoustic surveys of bat activity are a logistically feasible and cost-effective way of obtaining bat activity data. However, concerns regarding the methodological designs of many acoustic surveys are expressed in the scientific literature. The reasons are the failing of addressing temporal and spatial variation in bat activity patterns and the limitations of the suitability of the used acoustic detector systems. By comparing different methods and detector systems it was found that the set up of several stationary calibrated detector systems which automatically trigger the ultrasonic recording has the highest potential to produce reliable, unbiased and comparable data sets on the relative activity of bats.
By using the proposed survey method, bat diversity and activity was recorded in different crops and semi-natural habitats in southern Rhineland-Palatinate. Simultaneously, the availability of aerial prey insects was studied by using light and sticky traps. In more than 500 sampling nights about 110,000 call sequences were acoustically recorded and almost 120,000 nocturnal insects were sampled. A total of 14 bat species were recorded, among them the locally rare and critically endangered northern bat (Eptesicus nilssonii) and the barbastelle (Barbastella barbastellum), all of them also occurring over agricultural fields. The agricultural landscape of southern Palatinate is dominated by vineyards, a habitat that was shown to be of low quality for most bat species because of the demonstrated low availability of small aerial insects. By surveying bat activity and food availably in a pair-wise design on several rain water retention ponds and neighbouring vineyards it was demonstrated that aquatic insect emergence in artificial wetlands can provide an important resource subsidy for bats. The creation of artificial wetlands would be a possibility to create important foraging habitats for bats and mitigate negative effects of management practice in the agricultural landscape.
In several other agricultural crops, however, high abundances of suitable prey insects and high bat activity levels, comparable or even higher than in the nearby forests and meadows known to be used as foraging habitats were demonstrated. Especially high bat activity levels were recorded over several fruit orchards and vegetable fields where insects were also present. Both crops are known for high pesticide inputs, and, therefore, a pesticide exposure through ingestion of contaminated insects can not be excluded. To follow the current risk assessment approach for birds and mammals pesticide residues were measured on bat-specific food items in an apple orchard following insecticide applications and bat activity was recorded in parallel. The highest residue values were measured on foliage-dwelling arthropods which may results in a reproductive risk for all bat species that, even to a small extent, include this prey group in their diet. The presence of bats in agricultural landscapes that form a majority of the land area in Europe but also on a global scale leads to exposure of bats by contaminated food and depletion of their food resources by pesticide use. So far conservation efforts for bats focussed on securing hibernation sites and the creation of artificial roost sites since especially the latter were thought to be limiting population growth. However the potential pesticide effects might be also crucial for the population persistence in agricultural landscapes of bats and need to be addressed adequately, especially in risk assessment procedures for the regulation of pesticides.


Territory design and districting may be viewed as the problem of grouping small geographic areas into larger geographic clusters called territories in such a way that the latter are acceptable according to relevant planning criteria. The availability of GIS on computers and the growing interest in Geo-Marketing leads to an increasing importance of this area. Despite the wide range of applications for territory design problems, when taking a closer look at the models proposed in the literature, a lot of similarities can be noticed. Indeed, the models are many times very similar and can often be, more or less directly, carried over to other applications. Therefore, our aim is to provide a generic application-independent model and present efficient solution techniques. We introduce a basic model that covers aspects common to most applications. Moreover, we present a method for solving the general model which is based on ideas from the field of computational geometry. Theoretical as well as computational results underlining the efficiency of the new approach will be given. Finally, we show how to extend the model and solution algorithm to make it applicable for a broader range of applications and how to integrate the presented techniques into a GIS.


Almost three decades after the Islamic Republic's founding, former Islamic Revolutionary Guards Corps (IRGC) commanders are infiltrating the political, economic, and cultural life of Iran. Half the members of President Mahmoud Ahmadinejad's cabinet are former IRGC officers,[1] and he has appointed several IRGC officers to provincial governorships. The IRGC's rise has been deliberate. Facing both external opposition to Tehran's pursuit of an indigenous nuclear enrichment capability and internal pressures for political and economic reforms, Supreme Leader Ayatollah Ali Khamenei considers the IRGC officer corps more apt at crisis management than the bureaucratic teams of either former president Ali Akbar Hashemi Rafsanjani (1989-97) or Mohammad Khatami (1997-2005). IRGC chief General Mohammad Ali Ja'fari's announcement of internal restructuring to prepare the IRGC to counter "internal threats to the Islamic Republic"[2] reflects the organization's expanding role. The Council of Guardians, which screens candidates before elections, privileged IRGC veterans, who won the bulk of seats in the March 2008 parliamentary elections. Whereas there has always been tension within the Islamic Republic's elite concerning whether the Revolutionary Guards' political or military role should be dominant, recent shifts suggest the debate is concluding as the IRGC cements a commanding influence over political decisionmaking.


This article introduces Dr. Carol Dweck's seminal and significant line of psychological research on the phenomenon of implicit theories and draws on this research as a lens through which we might better understand judicial decision-making. In particular, the article focuses on the implications of two types of implicit theories – whether people believe that phenomena are static and fixed versus dynamic and malleable. By introducing this research, this article aims to forward a research agenda designed to examine how social, contextual, and situational forces influence judicial behavior. An entity theory reflects the mindset that phenomena are fixed and unlikely to change. An incremental theory reflects the mindset that phenomena are malleable and can be developed. Humans hold entity or incremental implicit theories about, for example, human nature, social institutions, and society. These theories, or "mindsets," affect perception, judgment, and decision-making and strongly shape how people organize their experience in, knowledge about, and transactions in the world. When an entity theory is salient, people expect that phenomena are fixed, immutable and unchangeable. However, when an incremental theory is salient, humans believe that phenomena are malleable, changeable, and affected by contexts and situations. Whether one holds an entity theory versus an incremental theory is often driven by situations, contexts, and social influences: a form of situated cognition. Implicit theories affect how jurists find facts, draw inferences, and impose punishment. Research on implicit theories, moreover, can enrich our understanding of how jurists apply the common law, engage in statutory interpretation, and construe the Constitution, offering novel insight into a timeless legal debate: whether American law is static versus dynamic. The article sets forth a research agenda that will form a line of psychological experiments to examine these processes.


A problem facing the United States and many other countries is how to finance retirement consumption as the number of their workers per retiree falls. The problem with a savings for retirement systems is that there is a shortage of good savings opportunities given the nature of most current tax systems and governments' limited ability to honor the debt it issues. We find that eliminating capital income taxes will greatly increase saving opportunities and make a savings-for-retirement system feasible with only modest amount of government debt. The switch from a system close to the current U.S. retirement system, which relies heavily on taxing workers' incomes and making lump-sum transfers to retirees, to one without income taxes will increase the welfare of all birth-year cohorts alive today and particularly the welfare of the yet unborn cohorts. The equilibrium paths for the current and alternative policies are computed.


Winner of the Pulitzer Prize, and now a documentary from Ken Burns on PBS, The Emperor of All Maladies is a magnificent, profoundly humane "biography" of cancer--from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist's precision, a historian's perspective, and a biographer's passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with--and perished from--for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out "war against cancer." The book reads like a literary thriller with cancer as the protagonist. From the Persian Queen Atossa, whose Greek slave may have cut off her diseased breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee's own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive--and to increase our understanding of this iconic disease. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.


This research attempted to find out factors that affect students' satisfaction in a higher learning Institution. The students were randomly selected from degree, masters and PhD programs to evaluate the level of students' satisfaction. The primary data source was a questionnaire that was distributed to the students. The researchers collected 165 completed questionnaires out of a total of 190. Four factors were chosen as independent variables namely; gender, race, student status and CGPA. This study showed that the overall services offered by the university was moderate from students' perspective. This means that the university has enough ability to continue its improvement. This study showed that the academic-related activities are more important than non academic-related such as the availability of financial advice and the level of decoration. The academic activities should not be limited to classroom activities only. It must cover everything that can develop and instill good values, attitude, character and strong personality. Universities world-wide are now competing both nationally and internationally. In order to attain new students and retain current students they should aim to enhance student satisfaction and reduce student dissatisfaction. This only can be achieved if all the services that related to academic life such as implicit services, explicit services and physical services must be delivered to a suitable standard. We also noticed that student status have an important influence on the perception of service quality. This is probably because student expectation increases as they have more contact with the university. Another element that also has influence on the perception of service quality is race and nationality. In relation to this, the academic or non-academic staffs that prepared services directly for the students should be able to identify and understand different levels of student expectations across years of study (from first year to final year) and races.


The faunal remains were collected during the archaeological researches carried out in 1988 and 2000. The analysed assemblage consists of 902 remains, out of which four are human (Homo sapiens). The remains originate from fish, birds and mammals. The mammalian bones number 615 remains, out of which 397 were identified by species. The list of identified domestic mammal comprise cattle (Bos taurus), sheep (Ovis aries), goat (Capra hircus), horse (Equus caballus), and pig (Sus domesticus), with domestic cattle prevailing. Only three species of wild mammals were identified: red deer (Cervus elaphus), wild boar (Sus scrofa) and roe deer (Capreolus capreolus); the largest number of remains belongs to red deer. There is a single fragment coming from birds and six fragments from reptiles (Testudo graeca and Emys orbicularis). Fish bones are numerous (276), and the identified species are pike (Esox lucius), common carp (Cyprinus carpio), tench (Tinca tinca), wels catfish (Silurus glanis), and zander (Sander lucioperca); the highest share is represented by the common carp. Archaeogenetic analyses were carried out for some swine remains from Romanian territory, dating from the Iron Age, in order to identify their genetic profile. The analysed samples presented two different ancient haplotypes, previously described in the literature, haplotypes that sustained the pattern of spread for the domestic pigs on the European continent.


Governments around the world continue to struggle with how to accommodate religious minorities in an increasingly pluralistic society, and how to accommodate religion in matters of family law. Efforts to respect religious understandings in family disputes seem at first blush innocuous: they would allow religious groups to define their own norms and celebrate the rich diversity of society. However, the experience of women and children of multiple faiths across the world demonstrates that religious deference extracts an unconscionable price. As the Volume in which this Chapter appears illustrates, such proposals would confer considerable latitude in family matters not only on adherents of Islam, but on Christians, Jews, and members of other faiths. This Chapter argues that such efforts are well-intentioned but naive. Religious communities are not immune from family violence, and religious norms place women at significant financial and custodial disadvantages. In many instances, there are striking breaks between civil law norms and the outcomes demanded by religious understandings in places where religious arbitration is occurring. The experiences of women and children demonstrate that removing state protections from the family is fraught with peril. In some systems of religious deference, the cost of exiting a marriage, even an abusive one, for women is unconscionable - leading to a substantial risk of poverty and sometimes the loss of child custody after divorce. Some religious leaders tolerate family violence, further frustrating a woman's ability to exit an abusive marriage. The foreseeable inequities to women and children in systems of religious deference cannot be justified on grounds that a woman voluntarily chooses to participate. Unlike prenuptial agreements, which must be in writing and are policed for duress and unconscionability, existing systems of religious deference offer no such safeguards. This Chapter concludes that policymakers should give serious consideration to the costs of giving deference to religious understandings of family relationships before ceding authority for family disputes to religious bodies.


Representations of Rwanda have been shaped by the display of bodies and bones at Tutsi genocide memorial sites. This phenomenon is most often only studied from the perspective of moral dimensions. This article aims in contrast to cover the issues related to the treatment of human remains in Rwanda for commemorative purposes from a historical perspective. To this end, it is based on the archives of the commissions in charge of genocide memory in Rwanda, as well as interviews with key memorial actors. This study shows the evolution of memorial practices since 1994 and the hypermateriality of bodies in their use as symbols, as well as their demobilisation for the purposes of reconciliation policies.


Fatalism about natural disasters hinders action to prepare for those disasters, and overcoming this fatalism is one key element to preparing people for these disasters. Research by Bostrom and colleagues shows that failure to act often reflects gaps and misconceptions in citizen's mental models of disasters. Research by McClure and colleagues shows that fatalistic attitudes reflect people's attributing damage to uncontrollable natural causes rather than controllable human actions, such as preparation. Research shows which precise features of risk communications lead people to see damage as preventable and to attribute damage to controllable human actions. Messages that enhance the accuracy of mental models of disasters by including human factors recognized by experts lead to increased preparedness. Effective messages also communicate that major damage in disasters is often distinctive and reflects controllable causes. These messages underpin causal judgments that reduce fatalism and enhance preparation. Many of these messages are not only beneficial but also newsworthy. Messages that are logically equivalent but are differently framed have varying effects on risk judgments and preparedness. The causes of harm in disasters are often contested, because they often imply human responsibility for the outcomes and entail significant cost.


The contemporary debate over whether senior Bush Administration officials should be investigated (and potentially prosecuted) for their role in the U.S. government's torture of individuals detained as "enemy combatants" during the war on terrorism has been curiously indifferent to American history. Even the most modest perusal of that history reveals - perhaps surprisingly - little precedent for holding personally to account those senior government officials most responsible for our gravest civil liberties and human rights abuses. Perhaps the most prominent example comes from one of the darkest civil liberties chapters in American history, the exclusion from the West Coast and internment of over 120,000 Japanese nationals and U.S. citizens of Japanese descent during World War II, and the implicit but unequivocal legal sanction given to these measures by the Supreme Court in a trio of rulings culminating with Korematsu v. United States in December 1944. As this chapter argues, more than just a temporal bookend, both Korematsu's holding and its history provide illuminating lenses through which to situate these contemporary debates. In particular, the future Justice Jackson warned about in his enigmatic dissent never materialized; and the moral judgments to which he referred have been, at least over time, rather unkind. Korematsu's reasoning has been soundly discredited (and never again invoked as authoritative); Fred Korematsu's conviction has been vacated; and the internment camps in general are today almost universally condemned as one of the darkest civil liberties chapters in modern American history - so much so that Congress formally apologized for the camps in 1988. Moreover, and critically, this consensus narrative discrediting internment in general and Korematsu in particular has emerged even though no one was ever held personally liable for the policies that led to the camps. No military or executive branch official was prosecuted or sued for violating the internees' rights; no government lawyer was disbarred - despite proof that the Justice Department affirmatively misled the courts as to the gravity of the military threat posed by Japan, especially in the second round of briefing before the Supreme Court in Korematsu. In short, we have come to accept the wrongfulness of internment, even without clarity as to the specific legal violation that internment represented or the personal liability of individual government officials for its commission. Somehow, the conclusion seems inescapable today that the rule of law in the United States eventually survived the damage wrought by Korematsu, notwithstanding (or perhaps thanks to) Justice Jackson's fear that it might not. The question - and the central focus of this chapter - is whether Jackson's understanding of the relationship between internment and the rule of law, and the subsequent creation of internment's historical memory, might help us to assess the stakes of today's debate. Put another way, if, like the majority opinion in Korematsu, the OLC opinions - and not the acts of torture themselves - pose the real danger to the rule of law going forward, are there lessons that we can learn from the creation of internment's historical narrative (at the expense of Korematsu) that will help us undo whatever damage the OLC opinions have caused, and perhaps without individual criminal liability?


Not just a system of checks and balances ideally tuned to constrain collective political action, the constitutional separation of powers also may be seen as a system of "prods and pleas" in which distinct governmental branches and actors can push each other to entertain collective political action when necessary. Though an inversion of the assumed direction of checks and balances, such prods and pleas are not a radical reconfiguration of the basic structure and principles of American government. Rather, they are limited government's failsafe: a latent capacity inherent to a system of divided authority that does and should activate when the external pressures of a changing world threaten the sustainability of disaggregated governance. By understanding and embracing their role in the shadow logic of prods and pleas, judges and other public officials can protect limited government by, when necessary, counteracting its potential to over-prefer passivity. Through the case study of climate change nuisance litigation - particularly American Electric Power v. Connecticut, a case pending in the Supreme Court of the United States - we examine how three potential obstacles to merits adjudication - political question doctrine, standing, and preemption - should be evaluated in recognition of the significance of prods and pleas. We conclude that federal and state tort law provide an important defense mechanism that can help limited government sustain itself in the face of climate change and other dramatic twenty-first century threats, where the nature of the threat is, in large part, a function of limited government itself. As a residual locus for the airing of grievances when no other government actor is responsive to societal need, the common law of tort is a - and perhaps the - paradigmatic vehicle for the expression of prods and pleas. Although climate change plaintiffs still face long odds on the actual merits of their claims, judges would sell short their institutional role if they dismissed such claims as categorically beyond the proper domain of the courts and the common law. They would duck and weave when they should prod and plea.


The concept of closure, almost unknown two decades ago, has had a meteoric rise. It has been enthusiastically embraced by the legal system not only as a legitimate psychological state, but as one that the criminal justice system ought to help victims and murder survivors to attain. In the death penalty context, the concept of closure has changed the way we talk about the rationale for capital punishment, it has changed the shape of the legal process, and it has even changed what both survivors and jurors in capital cases expect to feel. Yet, as I will illustrate, the term closure in fact connotes several different and poorly differentiated concepts, each with separate and quite serious implications for the conduct of the capital trial. For example, depending on how closure is understood, it might require a chance to give public testimony, an opportunity to meet with the accused, a more expeditious trial, a sentence of death, or an execution. Yet there is inadequate evidence on whether any of these institutional processes or outcomes can actually contribute to a state of closure for survivors. As current research in disciplines including cognitive neuroscience, sociology, psychology, and political science suggests, emotions are dynamic processes that evolve in a reciprocal relationship with social structures. As the legal system becomes increasingly invested in helping victims and survivors achieve closure, we need to take a hard look at the emotional content of this concept, and at how it affects, and is affected by, the institutional framework in which it operates.


As the sustained trend towards integrating more and more functionality into systems on a chip can be observed in all fields, their economic realization is a challenge for the chip making industry. This is, however, barely possible today, as the ability to design and verify such complex systems could not keep up with the rapid technological development. Owing to this productivity gap, a design methodology, mainly using pre designed and pre verifying blocks, is mandatory. The availability of such blocks, meeting the highest possible quality standards, is decisive for its success. Cost-effective, this can only be achieved by formal verification on the block-level, namely by checking properties, ranging over finite intervals of time. As this verification approach is based on constructing and solving Boolean equivalence problems, it allows for using backtrack search procedures, such as SAT. Recent improvements of the latter are responsible for its high capacity. Still, the verification of some classes of hardware designs, enjoying regular substructures or complex arithmetic data paths, is difficult and often intractable. For regular designs, this is mainly due to individual treatment of symmetrical parts of the search space by backtrack search procedures used. One approach to tackle these deficiencies, is to exploit the regular structure for problem reduction on the register transfer level (RTL). This work describes a new approach for property checking on the RTL, preserving the problem inherent structure for subsequent reduction. The reduction is based on eliminating symmetrical parts from bitvector functions, and hence, from the search space. Several approaches for symmetry reduction in search problems, based on invariance of a function under permutation of variables, have been previously proposed. Unfortunately, our investigations did not reveal this kind of symmetry in relevant cases. Instead, we propose a reduction based on symmetrical values, as we encounter them much more frequently in our industrial examples. Let \(f\) be a Boolean function. The values \(0\) and \(1\) are symmetrical values for a variable \(x\) in \(f\) iff there is a variable permutation \(\pi\) of the variables of \(f\), fixing \(x\), such that \(f|_{x=0} = \pi(f|_{x=1})\). Then the question whether \(f=1\) holds is independent from this variable, and it can be removed. By iterative application of this approach to all variables of \(f\), they are either all removed, leaving \(f=1\) or \(f=0\) trivially, or there is a variable \(x'\) with no such \(\pi\). The latter leads to the conclusion that \(f=1\) does not hold, as we found a counter-example either with \(x'=0\), or \(x'=1\). Extending this basic idea to vectors of variables, allows to elevate it to the RTL. There, self similarities in the function representation, resulting from the regular structure preserved, can be exploited, and as a consequence, symmetrical bitvector values can be found syntactically. In particular, bitvector term-rewriting techniques, isomorphism procedures for specially manipulated term graphs, and combinations thereof, are proposed. This approach dramatically reduces the computational effort needed for functional verification on the block-level and, in particular, for the important problem class of regular designs. It allows the verification of industrial designs previously intractable. The main contributions of this work are in providing a framework for dealing with bitvector functions algebraically, a concise description of bounded model checking on the register transfer level, as well as new reduction techniques and new approaches for finding and exploiting symmetrical values in bitvector functions.


The collection is extremely strong in diversity of island species throughout the world. Also the collection contains significant historical collections of importance: James Henry Fleming, James A. Munro, Hoyes Lloyd, part of the Haverschmidt collection from the Guyanas, R. G. Lanning, H.B. Haugh collection of birds eggs from Southern Ontario. The Fleming collection, once considered the most comprehensive private collection of birds in North America, contains many unique collections from Africa, Europe, India, China, and Island Archipelagos of the world. Representative collections of the magnificent Birds of Paradise (Passeriformes; Paradisaeidae) and Bower Birds (Passeriformes; Ptilonorhynchidae) (from the Fleming Collection) has been described as within the top 10 in world by researchers. Sub-collections of the J.H. Fleming, J.A. Munro collections are considered historically significant to the Ornithological community. Other significant collections are The New World Sparrows (Passeriformes: Emberizidae); the North American Wood Warblers (Passeriformes: Parulidae); Shorebirds, Gulls and Auks (Charadriiformes) and the Chicken-like birds (Galliformes) of North America, New World Vireos and Allies (Passeriformes: Vireonidae). The study skin collection contains one of the largest collections in the world of extinct birds including 132 Passenger Pigeon specimens (skins) and New Zealand Huias famed for their sexually dimorphic bills. 1 specimen of the extinct Labrador Duck (1 of 54 mounted skins in world). 1 specimen of the extinct Great Auk (1 of 78 mounted skins in world), miscellaneous skeletal parts of Great Auk specimens, 14 specimens of the extinct Carolina Parakeet and many other species. The skin collection contains historically significant holdings of the highly endangered Hawaiian Honeycreepers (Passeriformes: Fringillidae Drepanididae) from the Fleming collection, 1840s through to 1913, and the famous Darwin's finches. The frozen tissue collection contains the largest collection of blood and DNA from endangered kiwi populations in New Zealand, as well as bone shavings and DNA from the 14 extinct species of giant moas. Extensive series of New World Owls. Extensive series of New World Flycatchers. Large series of New World Sparrows.


The current study evaluated engineering college students' self-regulated learning (SRL) strategies while learning electric circuit concepts using enhanced guided notes (EGN). Our goal was to describe how students exercise SRL strategies and how their grade performance changes after using EGN. Two research questions guided the study: (1) To what degree students' grade performance change after using the EGN?; and (2) To what degree students' SRL profiles change after using the EGN? The subjects for this study were 97 engineering students enrolled in the Fundamental Electronics for Engineers course at a university in Utah. A survey instrument developed using Butler and Cartier's SRL model was used to capture SRL strategies with a focus on the sixth feature which includes including planning, monitoring, and regulating. Regular examinations and the DC/AC conceptual inventory were used to assess grade performance. Descriptive statistics, independent and paired t-tests, and a cluster analysis technique were used to analyze survey data. A phenomenological data analysis was used to analyze interview transcripts to support findings from questionnaire data. The findings revealed an improvement on students' grade performance. Data analysis of the SRL survey revealed that students' had different SRL profiles. Students in the improved group reported a greater awareness of planning, monitoring, and regulating strategies. On the other hand, those in the declined group showed a lower awareness of the SRL strategies at the end of semester. In addition, emergent themes related to students' SRL and learning experience while using the EGN were found. This article will also discuss the potential implications for electric circuit concepts instructions.


100 easy and delicious meals on a tight budget with Jack Monroe's A Girl Called Jack. Jack is a cash-strapped single mum living in Southend. When she found herself with a shopping budget of just GBP10 a week to feed herself and her young son, she addressed the situation with immense resourcefulness, creativity and by embracing her local supermarket's 'basics' range. She created recipe after recipe of delicious, simple and upbeat meals that were outrageously cheap. Learn with Jack Monroe's A Girl Called Jack how to save money on your weekly shop whilst being less wasteful and creating inexpensive, tasty food. Recipes include Vegetable Masala Curry for 30p a portion, Pasta alla Genovese for 19p a portion, Fig, Rosemary and Lemon Bread for 26p and a Jam Sponge reminiscent of school days for 23p a portion. "Sassy, political, and cooking amazing food on GBP10 a week. We need more like her". (Xanthe Clay, The Telegraph). Jack Monroe is a 24-year-old single mother and local newspaper reporter. Finding herself with a food budget of just GBP10 a week, she began to create nutritious recipes to feed herself and her son. Giving the recipes out to a local food bank, to help others in her situation, she then began to publish them online on her blog, A Girl Called Jack, which now has thousands of followers. Jack was awarded the 2013 Fortnum and Mason Judges' Choice Award for the impact that her blog has had. She lives in Essex with her son.


During several cruises of r/v 'Oceania' in different seasons of 1993–1997 detailed investigations of the Pomeranian Bay were carried out with particular attention to the vicinity of the Odra river mouth. On the basis of CTD soundings as well as quasi-continuous profiling by means of a towed CTD probe, the thermohaline fields were analysed in order to determine the pattern of riverine water transport. The characteristic flow paths under different meteorological conditions were identified, Ekman transport of freshened waters being found to prevail along the coasts of the Pomeranian Bay. Physical phenomena such as the pulsating outflow of the river Odra and the formation of isolated plumes of freshened water were observed. The vertical and horizontal extents as well as the lifetime and speed of movement of the plume-like structures were estimated. A typical plume was a few km in diameter and there were steep horizontal and vertical salinity gradients at the boundaries. As the plume moved away from the mouth, it was transformed and finally vanished. There was strong wind mixing and entrainment into underlying, more saline water at some distance from the channel mouth. Hydrological fronts between riverine and ambient waters frequently formed. Numerous intrusions were found in the temperature and salinity profiles in the frontal zones. The freshwater fraction in the entire volume * The studies were sponsored by the Foundation for Polish-German Co-operation's research project in the Pomeranian Bay. 280 A. Beszczyńska-Möller of the bay waters was estimated for different hydrological situations, the highest values being obtained for the period following the flood event of summer 1997. Under favourable wind conditions, dense, saline waters flowing in from the Arkona and Bornholm Deeps were present in the near-bottom layer at the edges of the bay. Anomalously, waters of higher salinity were found in the Pomeranian Bay in November 1997 as a result of a minor inflow from the Danish Straits.


Combining the best features of traditional and modern methods, Athenaze: An Introduction to Ancient Greek, 2/e, provides a unique course of instruction that allows students to read connected Greek narrative right from the beginning and guides them to the point where they can begin reading complete classical texts. Carefully designed to hold students' interest, the course begins in Book I with a fictional narrative about an Attic farmer's family placed in a precise historical context (432-431 B.C.). This narrative, interwoven with tales from mythology and the Persian Wars, gradually gives way in Book II to adapted passages from Thucydides, Plato, and Herodotus and ultimately to excerpts of the original Greek of Bacchylides, Thucydides, and Aristophanes' Acharnians. Essays on relevant aspects of ancient Greek culture and history are also provided. New to the Second Edition: * Short passages from Classical and New Testament Greek in virtually every chapter * The opening lines of the Iliad and the Odyssey toward the end of Book II * New vocabulary and more complete explanations of grammar, including material on accents * Many new exercises and additional opportunities for students to practice completing charts of verb forms and paradigms of nouns and adjectives * Updated Teacher's Handbooks for Books I and II containing translations of all stories, readings, and exercises; detailed suggestions for classroom presentation; abundant English derivatives; and additional linguistic information * Offered for the first time, Student Workbooks for Books I and II that include self-correcting exercises, cumulative vocabulary lists, periodic grammatical reviews, and additional readings


Until the last quarter of the twentieth century it was a commonplace that the various expressions of economic substantive due process we associate with the so-called "Lochner Era" were animated by laissez-faire economics and Social Darwinism. More recent assessments have persuasively rejected this view, observing that the Court as a whole and the justices individually voted to uphold many more instances of government regulation of the economy than they voted to invalidate, and that the closest thing to a Social Darwinist that the Court had to offer was Justice Holmes, on whose polemical dissent in Lochner the conventional wisdom had been based. Since the 1970s, revisionist scholars have come instead to see these doctrines as expressions of what Professor Howard Gillman has called a "principle of neutrality." That master principle was grounded in such antebellum ideological concerns as the aversion to factional politics and the Jacksonian revulsion against special privilege, and was best understood as prohibiting what was at the time called "class legislation" or "special legislation" or "partial legislation" – legislation that could not be deemed public-regarding because it singled out particular groups for unjustified special benefits or burdens. On this view economic substantive due process was concerned primarily with formal equality; but a number of revisionists recognized, as the doctrine of "liberty of contract" would suggest, that such an explanation was incomplete. These scholars understood that the Court's due process jurisprudence also was devoted to the protection of liberty, especially so in the context of employment; and they traced that feature of substantive due process to the anti-slavery free labor ideology of the antebellum Republican Party that informed such Reconstruction landmarks as the 13th and 14th Amendments and the Civil Rights Act of 1866. At the center of that ideology lay the conviction that the essential characteristic distinguishing the free man from the slave was self-ownership, and particularly ownership of one's own labor. Self-ownership entailed the right to dispose of one's labor on the terms of one's choosing, and regulations of that right that could not be justified as preventing fraud or protecting public health, safety, or morals were mere "meddlesome interferences" with a fundamental liberty of free men. On this account, free labor ideology in the post-bellum period operated as a source of rights, restraining the state from interfering with individual liberty. Advocates of prison labor reform, by contrast, were more interested in exploring the implications of free labor ideology as a source of state power to restrict rights of property and contract. Throughout the 19th century, organized workers agitated for the reform of the system of convict labor, contending that goods manufactured with cheap prison labor competed unfairly with goods produced in the private economy and thereby depressed wages. They viewed convict labor as a species of slave labor that threatened to degrade free laborers, impeding their capacity to acquire capital and to enjoy the upward social mobility that free labor ideology promised to industrious, disciplined workmen. The State of New York became a national leader in this reform effort. The legislature abolished various objectionable forms of convict labor, and prohibited the sale of goods manufactured in its prisons on the private market. Convict-made goods produced in other states and shipped into New York, however, continued to compete with products produced by free labor in New York, and the New York statutes regulating the sale of these out-of-state goods raised contentious issues under both the Dormant Commerce Clause and the Fourteenth Amendment. As Professor William E. Nelson has argued, late nineteenth century jurists viewed the inherent individual right to freedom of contract as embracing "the right to use and dispose of property." "Every man...had a 'natural right to sell or keep his commodities as best suit[ed] his own purpose.'" "The right to use and dispose of property was viewed as a necessary consequence of the right to acquire and hold it." The question presented under the Fourteenth Amendment was whether New York's efforts to protect its free laborers deprived the owner and seller of convict-made goods of property rights without due process or denied him equal protection of the laws. Put another way, the question was whether free labor ideology operated not only as a shield but also as a sword, underwriting police power regulation of private property. This essay, prepared in Professor Nelson's honor, explores the manner in which the courts of his native New York struggled uneasily with that question for two decades, and the way in which it was ultimately resolved in favor of the free labor interest by United States Supreme Court Justices deeply invested in economic substantive due process.


BACKGROUND
Maternal depression during pregnancy is associated with an increased risk of adverse child outcomes. One potential mechanism is the influence of antenatal depression on the foetal hypothalamic-pituitary-adrenal axis. This can be observed as disturbances in baseline cortisol secretion during childhood. The influence of antenatal depression on infant cortisol reactivity to a stressor may provide further insight into this association. In addition, the dose-response relationship between foetal exposure to antenatal depression and infant cortisol reactivity is unclear.

METHODS
A consecutive sample of 133 pregnant women in their third trimester was recruited from an antenatal clinic in Karnataka, South India. Women were assessed for depression before and after birth on the Edinburgh Postnatal Depression Scale (EPDS) and the Kessler 10 Scale. Salivary cortisol response to immunization was measured in 58 infants at 2 months of age. We aimed (i) to investigate the association between antenatal depression and infant cortisol reactivity to immunization and (ii) to explore whether the relationship is dose-dependent.

RESULTS
Exposure to antenatal depression independently predicted elevated infant cortisol responses to immunization (β = 0.53, P = 0.04). The association was found to be U-shaped, for antenatal depression measured on the EPDS, with the infants exposed to the highest and lowest levels of maternal antenatal EPDS scores during intra-uterine life showing elevated cortisol responses to immunization (R(2) = 0.20, P = 0.02). Infants exposed to moderate levels of maternal antenatal depression showed the lowest cortisol response to immunization.

CONCLUSIONS
These findings suggest that the association between antenatal depression and infant cortisol reactivity is dose-dependent and U-shaped, implying that infants exposed to both low and high levels of maternal depression showed greater reactivity. The study provides the first evidence of such an association from a low-income setting.


A graph $G$ is well-covered if every maximal independent set has the same cardinality. Let $s_k$ denote the number of independent sets of cardinality $k$, and define the independence polynomial of $G$ to be $S(G,z) = \sum s_kz^k$. This paper develops a new graph theoretic operation called power magnification that preserves well-coveredness and has the effect of multiplying an independence polynomial by $z^c$ where $c$ is a positive integer. We will apply power magnification to the recent Roller-Coaster Conjecture of Michael and Traves, proving in our main theorem that for sufficiently large independence number $\alpha$, it is possible to find well-covered graphs with the last $(.17)\alpha$ terms of the independence sequence in any given linear order. Also, we will give a simple proof of a result due to Alavi, Malde, Schwenk, and Erdős on possible linear orderings of the independence sequence of not-necessarily well-covered graphs, and we will prove the Roller-Coaster Conjecture in full for independence number $\alpha \leq 11$. Finally, we will develop two new graph operations that preserve well-coveredness and have interesting effects on the independence polynomial.


Investors are becoming a lot more independent these days. With the stock market sinking and soaring from day to day, retirement plans becoming less certain, and a longer life expectancy in retirement, more people are looking for some control over their investments. If youre one of them, Investing Online For Dummies, 6th Edition might be just what youre looking for. The Internet brings a world of investment resources to your desktop, but how do you find your way through the dizzying array of investment possibilities? The Dummies Way, of course! This book helps you set reasonable expectations, assess your risk tolerance, choose an asset allocation, analyze and select investments, and maximize your financial success. Youll discover how to Determine how much you can afford to invest Choose an online broker Research, trade, and track investments online Measure the potential return of a stock Maximize your investment knowledge and build a profitable portfolio Buy bonds online Understand options, commodities, and IPOs If youve decided to take control of your investments but dont want to make it your full-time job, Investing Online For Dummies, 6th Edition gives you the important information that will also give you confidence. Completely updated to cover all the new online tools and resources, it even provides some bonus assistance on the companion Web site.


Over the past 40 years, physical activity (PA) and public health has been established as a field of study. A robust evidence base has emerged demonstrating that participation in recommended amounts of PA results in a wide array of physical and mental health benefits. This led to the establishment of federal and global PA guidelines and surveillance programs. Strong evidence supports the efficacy of individual-level (e.g., goal setting) and environmental (e.g., policies) interventions to promote PA. There has also been progress in establishing a skilled and diverse workforce to execute the work of PA and public health. Looking forward, major challenges include stemming the obesity and chronic disease epidemics, addressing health inequities, and diversifying the workforce. Given the known benefits of PA and the availability of evidence-based interventions, efforts now must focus on implementing this knowledge to improve population health and reduce inequities through PA.


INDIANAPOLIS – The first study to examine the actual willingness of older adults to be screened for dementia has found that acceptance of screening is pervasive, although it varies by age. However, willingness to be screened for dementia does not differ by sex, race or income level. Almost 90 percent of the 554 people in the study, who ranged in age from 65 to 96, indicated their willingness by undergoing actual screening. The odds of refusal were higher for patients age 70 to 79 than for those age 65 to 69 or for those age 80 or older. Refusal rates were lowest for those who ranged in age from 65 to 69. Seventy percent of study participants were female, and slightly over half of those in the study were African-American. Three quarters of the older adults had an annual income of less than $20,000. Neither sex, race nor income level affected the study participants' willingness to undergo dementia screening. Refusal rates also did not vary by education level. ''Unlike past studies which asked about theoretical willingness to be screened for dementia and found less interest, we looked at actual willingness of primary care patients to be screened,'' said Regenstrief Institute investigator Malaz Boustani, M.D., MPH, associate professor of medicine at the Indiana University School of Medicine. A geriatrician, Dr. Boustani is the study's corresponding author and principal investigator. He is also medical director of the Healthy Aging Brain Center at Wishard Health Services, the public hospital where the study was conducted. The majority of older adults receive their health care from primary care physicians. ''We were surprised by the fact that only one in 10 older adults did not want to be screened for dementia, and we believe this finding of an extremely high level of acceptance of screening by our well-powered study will help doctors and the United States Preventive Services Task Force evaluate the benefits and harms of dementia screening by providing the voice and perceptions of patients,'' said Dr. Boustani, who pointed out that if dementia screening is recommended in the future, special efforts will need to be employed to reach those in their 70s because of their higher rate of refusal. "Effect of Patient Perceptions on Dementia Screening in Primary Care" appears in the June issue of the Journal of the American Geriatrics Society. In addition to Dr. Boustani, co-authors of the study are Nicole R. Fowler, Ph.D. of the University of Pittsburgh; Amie Frame, MPH, and Anthony J. Perkins, M.S., of the Regenstrief Institute; Patrick Monahan, Ph.D. and Sujuan Gao, Ph.D., of the IU School of Medicine; and Greg A. Sachs, M.D., and Hugh C. Hendrie, M.B., Ch.B., D.Sc., of the Regenstrief Institute and the IU School of Medicine. Frame, Perkins and Drs. Monahan, Gao, Sachs and Hendrie are also with the IU Center for Aging Research, of which Dr. Boustani is associate director. Study participants who indicated stronger agreement to statements about the benefits of knowing about dementia earlier (for example, ability to plan for the future) were more likely to accept screening. Of the 497 individuals screened in the study, 13 percent were found to be positive for dementia and were referred for a confirmatory diagnostic assessment. (Source: EurekAlert! A service of AAAS and Indiana University School of Medicine).


Eleven-nineteen leukemia (ENL) contains an epigenetic reader domain (YEATS domain) that recognizes lysine acylation on histone 3 and facilitates transcription initiation and elongation through its interactions with the super elongation complex (SEC) and the histone methyl transferase DOT1L. Although it has been known for its role as a fusion protein in mixed lineage leukemia (MLL), overexpression of native ENL, and thus dysregulation of downstream genes in acute myeloid leukemia (AML), has recently been implicated as a driver of disease that is reliant on the epigenetic reader activity of the YEATS domain. We developed a peptide displacement assay (histone 3 tail with acylated lysine) and screened a small-molecule library totaling more than 24,000 compounds for their propensity to disrupt the YEATS domain–histone peptide binding. Among these, we identified a first-in-class dual inhibitor of ENL (Kd = 745 ± 45 nM) and its paralog AF9 (Kd = 523 ± 53 nM) and performed "SAR by catalog" with the aim of starting the development of a chemical probe for ENL.


How many times have you thought about starting a diet or quitting smoking without doing anything about it? Or lapsed back into bad habits after hitting a rough spot on the road to recovery?To uncover the secret to successful personal change, three acclaimed psychologists studied more than 1,000 people who were able to positively and permanently alter their lives without psychotherapy. They discovered that change does not depend on luck or willpower. It is a process that can be successfully managed by anyone who understands how it works. Once you determine which stage of change you're in, you can: create a climate where positive change can occurmaintain motivationturn setbacks into progressmake your new benefifificial habits a permanent part of your lifeThis groundbreaking book offers simple self-assessments, informative case histories, and concrete examples to help clarify each stage and process. Whether your goal is to start saving money, to stop drinking, or to end other self-defeating or addictive behaviors, this revolutionary program will help you implement positive personal change . . . for life.The National Cancer Institute Found this program more than twice as effective as standard programs in helping smokers quit for 18 months.


The Java Virtual Machine (JVM) executes the compiled bytecode version of a Java program and acts as a layer between the program and the operating system. The JVM provides additional features such as Process, Thread, and Memory Management to manage the execution of these programs. The Garbage Collection (GC) is part of the memory management and has an impact on the overall runtime performance because it is responsible for removing dead objects from the heap. Currently, the execution of a program needs to be halted during every GC run. The problem of this stop-the-world approach is that all threads in the JVM need to be suspended. It would be desirable to have a thread-local GC that only blocks the current thread and does not affect any other threads. In particular, this would improve the execution of multi-threaded Java programs. An object that is accessible by more than one thread is called escaped. It is not possible to thread-locally determine if escaped objects are still alive so that they cannot be handled in a thread-local GC. To gain significant performance improvements with a thread-local GC, it is therefore necessary to determine if it is possible to reliably predict if a given object will escape. Experimental results show that the escaping of objects can be predicted with high accuracy based on the line of code the object was allocated from. A thread-local GC was developed to minimize the number of stop-the-world GCs. The prototype implementation delivers a proof-of-concept that shows that this goal can be achieved in certain scenarios.


The use of cloud technology can offer significant savings for the deployment of services, provided that the service is able to make efficient use of the available virtual resources to meet service-level requirements. To avoid software designs that scale poorly, it is important to make deployment decisions for the service at design time, early in the development of the service itself. ABS offers a formal, model-based approach which integrates the design of services with the modeling of deployment decisions. In this paper, we illustrate the main concepts of this approach by modeling a scalable pool of workers with an auto-scaling strategy and by using the model to compare deployment decisions with respect to client traffic with peak loads.


By supporting small-scale agricultural producers, policy makers in governments and donor agencies can help some of the poorest people in the world to improve their livelihoods. Unfortunately, evidence suggests that most donor and government policies are currently biased towards large-scale agriculture at the expense of small-scale producers, women, and rural communities. This briefing note draws on recent Oxfam research to describe specific examples of how policy makers can govern markets and incentivise commercial investment in agriculture that includes small-scale producers. Policy recommendations focus on three key principles: giving small-scale producers, particularly women, power in markets and in politics; protecting basic rights; and supporting inclusive markets.


This paper seeks to make three contributions to understanding how banks' executive pay has produced incentives for excessive risk-taking and how such pay should be reformed. First, although there is now wide recognition that pay packages focused excessively on short-term results, we analyze a separate and critical distortion that has received little attention. Equity-based awards, coupled with the capital structure of banks, tie executives' compensation to a highly levered bet on the value of banks' assets. Because bank executives expect to share in any gains that might flow to common shareholders, but are insulated from losses that the realization of risks could impose on preferred shareholders, bondholders, depositors, and taxpayers, executives have incentives to give insufficient weight to the downside of risky strategies. Second, we show that corporate governance reforms aimed at aligning the design of executive pay arrangements with the interests of banks' common shareholders - such as advisory shareholder votes on compensation arrangements, use of restricted stock awards, and increased director oversight and independence -cannot eliminate the identified problem. In fact, the interests of common shareholders could be served by more risk-taking than is socially desirable. Accordingly, while such measures could eliminate risk-taking that is excessive even from shareholders' point of view, they cannot be expected to prevent risk-taking that serves shareholders but is socially excessive. Third, we develop a case for using regulation of banks' executive pay as an important element of financial regulation. We provide a normative foundation for such pay regulation, analyze how regulators should monitor and regulate bankers' pay, and show how pay regulation can complement and reinforce the traditional forms of financial regulation.


This paper investigates why passengers pay substantially different fares for travel on the same airline between the same two airports. We investigate questions that are fundamentally different from those in the existing literature on airline price dispersion. We use a unique new dataset to test between two broad classes of theories regarding airline pricing. The first group of theories, as advanced by Dana (1999b) and Gale and Holmes (1993), postulates that airlines practice scarcity based pricing and predicts that variation in ticket prices is driven by differences between high demand and low demand periods. The second group of theories is that airlines practice price discrimination by using ticketing restrictions to segment customers by willingness to pay. We use a unique dataset, a census of ticket transactions from one of the major computer reservation systems, to study the relationships between fares, ticket characteristics, and flight load factors. The central advantage of our dataset is that it contains variables not previously available that permit a test of these theories. We find only mixed support for the scarcity pricing theories. Flights during high demand periods have slightly higher fares but exhibit no more fare dispersion than flights where demand is low. Moreover, the fraction of discounted advance purchase seats is only slightly higher on off-peak flights. However, ticket characteristics that are associated with second-degree price discrimination drive much of the variation in ticket pricing.


A major premise of this paper is that the failure—or limited achievements—of many large-scale nutrition programs is very often a function of insufficient sustainable capacities within communities and organizations responsible for implementing them. Following a brief review of the various rationales for an intensified focus on capacity and capacity development, the paper examines the linkages between nutrition programming and capacity development processes before proposing a new approach to assessing, analyzing, and developing capacity. The ensuing sections then focus in more detail on the ingredients and influences of capacity at the levels of the community, program management, supporting institutions, and the government. Finally, the implications of a more proactive focus on strengthening nutrition capacity for donor modes of operation and support priorities are discussed.


Researchers at The University of Texas M. D. Anderson Cancer Center have significantly refined the scientific understanding of how a cell begins the process of self-destruction - an advance they say may help in the design of more targeted cancer therapies. In the June 30, 2006 issue of the journal Cell, the research team found that a natural "brake" exists in a cell to prevent it from undergoing apoptosis, or programmed cell death, and they say that optimal anti-cancer therapies should take a two-pronged approach to overriding this brake in order to force a tumor cell to die. Very few drugs do this now, they say. The discovery "demonstrates that apoptosis is more complicated than had been believed, and consequently harder to achieve," says the study's lead author, Dean G. Tang, Ph.D., associate professor in the Department of Carcinogenesis in the Science Park Research Division of M. D. Anderson in Smithville, Texas. Apoptosis can occur when a cell has reached its lifespan, and so is "programmed" to die, or is initiated when a cell is damaged beyond repair or infected by a virus. Apoptosis is rare in cancer because tumor cells have adapted biological pathways to circumvent cell death, so many anti-cancer therapies focus on inducing apoptosis in these cells, Tang says. But the notion of how to push cancer cells to die has been flawed, Tang says. These new findings "overturn a scientific dogma so long accepted that it has become a textbook standard when talking about apoptosis," he continues. Researchers agree that the seminal event that leads to initiation of apoptosis is the release of a key protein known as cytochrome c (CC) from a cell's mitochondria, the organelle's energy storehouse. These molecules then bind to another protein called Apaf-1 in the cell cytoplasm, and together they form a scaffolding "death wheel" to activate enzymes called caspases that shred a cell apart. But what they also believed is that a cell needs extra energy from ATP to undergo apoptosis, and that this extra energy was produced from the "pools" of free nucleotides that exist in the cell cytoplasm. Nucleotides are the primary structural chemical units that make up DNA, RNA and proteins, and they combine to play a variety of roles in the cell, such as formation of ATP. However, through a series of biological and biochemical experiments, Tang and his research team found that adding ATP to a cancer cell could potentially impede apoptosis. They discovered that these nucleotide pools, in fact, act not to promote apoptosis through production of ATP, but to hinder it. They are "pro-survival factors" that prevent CC, when released from the mitochondria, from "seeing" Apaf-1 in the cytoplasm, Tang says. "When we induced some cell stress and damage, the low levels of CC that came out from the mitochondria were ineffective because they are sequestered by an ocean of free nucleotides and ATP," he says. "No one had ever realized this kind of barrier existed to impede apoptosis." They found that cell mitochondria needed to release a large and sustained volume of CC to overcome this nucleotide barrier, and they also found evidence that as soon as the release of CC increases, another mechanism kicks in that simultaneously begins to reduce the size of the nucleotide pool to allow CC to bind to Apaf-1, Tang says. The researchers say this kind of strategy makes sense for the cell, because it acts like a biological fail-safe system to protect against the errant release of CC from malfunctioning mitochondria. A large pool of free nucleotides along with complete ATP molecules normally exists in a healthy cell so that just a little CC could not mistakenly push the cell to self destruct, Tang says. "When CC is still limited in the cell, perhaps through an accidental release, the nucleotide pool will neutralize the CC so that the cell can stay alive," he says. "So, in a way, it takes a large amount of CC to convince the cell that the damage is real, and that is what you see when cardiac cells die after a heart attack, for example." This finding has direct implications for anti-cancer therapy, Tang says, suggesting how current therapy could be both inefficient and lead to resistance in a cell. "Many cancer drugs focus on pushing the mitochondria to release CC, and not on reducing the nucleotide pool, and our new model suggests that decreasing this pool is essential to produce sensitivity in cancer cells to apoptosis," Tang says. Cancers that quickly become resistant to therapy, such as melanoma and ovarian tumors, do so because they have found ways to prevent mitochondria from releasing a lot of CC, he says. Tumor cells also don't want to decrease their nucleotide pool, because they need ATP for continued functioning, he says. "An optimal cancer therapy should combine both strategies," Tang says. "They should maximize release of CC and maximize the decrease of nucleotide levels." Some chemotherapy drugs, like paclitaxel, cisplatin and etoposide, appear, coincidentally and perhaps inadvertently, to do both, and are very effective for specific cancers, he says. "But based on these new findings, we now have a new theoretical approach that can be used to help in the design of more targeted chemotherapy drugs," Tang says. "This will change the way that scientists now think about the role of nucleotides in cancer therapy." The study was funded by grants from the National Institutes of Health, the American Cancer Society, Department of Defense, and the American Heart Association. Co-authors from the study include M. D. Anderson researchers Dhyan Chandra, Ph.D., Mary Ayres, Ph.D., and Varsha Gandhi, Ph.D.; Shawn B. Bratton, Ph.D., and Maria D. Person, Ph.D., from the University of Texas at Austin; Yanan Tian, Ph.D., from Texas A&M University; and Angel G. Martin, Ph.D., and Howard O. Fearnhead, Ph.D., from the National Cancer Institute.


This thesis is a study of the aerodynamics of a generic model of the Apache wingsuit subjected to angle displacements at high velocity. The Apache wingsuit is a wing equipped jumpsuit, used to enhance the experience of skydiving by producing glide capability. The origin of this case is from an event were unstable behaviour was experienced by the pilot when a dive at 83 m/s (~300 km/h) was followed by an increase of angle of attack which triggered the incident. Aerodynamics regards a big number of phenomena. Many studies have been done on airplanes but not many on wingsuits and an important feature is that it is made out of fabric, which separates it a lot from the physical attributes which apply to an airplane. Basic divergence was considered for it applies well also for a wingsuit regarding physical features. The study aims to recreate these circumstances to determine whether the aerodynamics of the wingsuit are of unstable nature. A generic wingsuit model CAD model was generated in symmetry and in asymmetry through ANSA based on manufacture measurements and visual reference. Moments and forces were monitored while angle displacements were performed in CFD simulations in STARCCM+. Solutions were performed in steady state and seemed to show unreliable convergence above 40 degrees angle of attack were stall was introduced. The model did not reveal any unstable characteristics of the symmetric wingsuit and the asymmetric model did not show of any profound force generation. There seemed to be an overproduction of head-down pitch moment, but whether this was a mistake in design of an actual feature of the Apache is not confirmed.


This article claims that the ongoing debate about the structure and dynamics of Al Qaeda has failed to appreciate the importance of an organizational layer that is situated between the top leadership and the grass-roots. Rather than being "leaderless," it is the group's middle management that holds Al Qaeda together. In Clausewitzian terms, Al Qaeda's middle managers represent a center of gravity—a "hub of … power and movement"—that facilitates the grass-roots' integration into the organization and provides the top leadership with the global reach it needs in order to carry out its terrorist campaign, especially in Europe and North America. They are, in other words, the connective tissue that makes Al Qaeda work. The article substantiates this hypothesis by providing a number of case studies of Al Qaeda middle managers, which illustrate the critical role they have played in integrating the grass-roots with the top leadership. The policy implications are both obvious and important. If neither the top leadership nor the grass-roots alone can provide Al Qaeda with strategic momentum, it will be essential to identify and neutralize the middle managers, and—in doing so—"cause the network to collapse on itself."


This lively story has never been told before: the complete history of women's reading and the ceaseless controversies it has inspired. Belinda Jack's groundbreaking volume travels from the Cro-Magnon cave to the digital bookstores of our time, exploring what and how women of widely differing cultures have read through the ages. Jack traces a history marked by persistent efforts to prevent women from gaining literacy or reading what they wished. She also recounts the counter-efforts of those who have battled for girls' access to books and education. The book introduces frustrated female readers of many eras-Babylonian princesses who called for women's voices to be heard, rebellious nuns who wanted to share their writings with others, confidantes who challenged Reformation theologians' writings, nineteenth-century New England mill girls who risked their jobs to smuggle novels into the workplace, and women volunteers who taught literacy to women and children on convict ships bound for Australia. Today, new distinctions between male and female readers have emerged, and Jack explores such contemporary topics as burgeoning women's reading groups, differences in men and women's reading tastes, censorship of women's on-line reading in countries like Iran, the continuing struggle for girls' literacy in many poorer places, and the impact of women readers in their new status as significant movers in the world of reading.


In the 19th and 20th centuries, Spain was a key player in the military conflagrations that created modern Europe. From the Napoleonic Wars, through the dress rehearsal for World War II that was the Spanish Civil War, to the grim struggle against terrorism today, the military history of modern Spain has both shaped and reflected larger forces beyond its borders. This volume traces the course of Spanish military history, primarily during the 20th century. Chapter 1 provides the foundation for the role of the Spanish Army at home (the War of Independence [Napoleonic War], the Carlist Wars, and pronunciamientos), abroad (Morocco, 1859-60), and as an instrument for Liberal reforms in Spain. Chapter 2 covers the period following the Spanish-American War as the Army redirected its focus to the Spanish Protectorate in northern Morocco. This chapter covers the Rif Rebellion (1921-27), the dictatorship of Miguel Primo de Rivera (1923-30) and concludes with the end of the monarchy and the establishment of the 2nd Republic in 1931. Chapters 3 and 4 present the two armies of the Spanish Civil War, as well as their relationship to the warring factions of Nationalists and Republicans. Chapter 5 looks at the Spanish Army during World War II on the Eastern Front (Russia), in its overseas colonies, as well as in Spain. De-colonialism is covered in chapter 6 as Spain, following the lead of the other European powers, began to shed itself of its African empire. Chapter 8 charts Spain's integration into the Western defense community in the 1950s, its membership in NATO, and its participation in peacekeeping and humanitarian missions in the Balkans and the Middle East. Chapter 9 focuses on Spain's struggle against terrorism, both the domestic Basques of ETA (Fatherland and Liberty) and the newer conflict against al-Qaeda and radical Islamic fundamentalism.


Synthesis of DNA at chromosome ends by telomerase may be necessary for indefinite proliferation of human cells. A highly sensitive assay for measuring telomerase activity was developed. In cultured cells representing 18 different human tissues, 98 of 100 immortal and none of 22 mortal populations were positive for telomerase. Similarly, 90 of 101 biopsies representing 12 human tumor types and none of 50 normal somatic tissues were positive. Normal ovaries and testes were positive, but benign tumors such as fibroids were negative. Thus, telomerase appears to be stringently repressed in normal human somatic tissues but reactivated in cancer, where immortal cells are likely required to maintain tumor growth.


This marketing classic has been expanded to include new commentary, new illustrations, and a bonus book: The 11 Immutable Laws of Internet Branding Smart and accessible, The 22 Immutable Laws of Branding is the definitive text on branding, pairing anecdotes about some of the best brands in the world, like Rolex, Volvo, and Heineken, with the signature savvy of marketing gurus Al and Laura Ries. Combining The 22 Immutable Laws of Branding and The 11 Immutable Laws of Internet Branding, this book proclaims that the only way to stand out in today's marketplace is to build your product or service into a brand-and provides the step-by-step instructions you need to do so. The 22 Immutable Laws of Branding also tackles one of the most challenging marketing problems today: branding on the Web. The Rieses divulge the controversial and counterintuitive strategies and secrets that both small and large companies have used to establish internet brands. The 22 Immutable Laws of Branding is the essential primer on building a category-dominating, world-class brand.


Random Forests is a statistical learning method which
has been proposed for propensity score estimation models that
involve complex interactions, nonlinear relationships, or both of
the covariates. In this dissertation I conducted a simulation study
to examine the effects of three Random Forests model specifications
in propensity score analysis. The results suggested that, depending
on the nature of data, optimal specification of (1) decision rules
to select the covariate and its split value in a Classification
Tree, (2) the number of covariates randomly sampled for selection,
and (3) methods of estimating Random Forests propensity scores
could potentially produce an unbiased average treatment effect
estimate after propensity scores weighting by the odds adjustment.
Compared to the logistic regression estimation model using the true
propensity score model, Random Forests had an additional advantage
in producing unbiased estimated standard error and correct
statistical inference of the average treatment effect. The
relationship between the balance on the covariates' means and the
bias of average treatment effect estimate was examined both within
and between conditions of the simulation. Within conditions, across
repeated samples there was no noticeable correlation between the
covariates' mean differences and the magnitude of bias of average
treatment effect estimate for the covariates that were imbalanced
before adjustment. Between conditions, small mean differences of
covariates after propensity score adjustment were not sensitive
enough to identify the optimal Random Forests model specification
for propensity score analysis.


Nine years, one Supreme Court decision, two statutes, and a veritable mountain of popular and academic discourse after President Bush's November 2001 Executive Order creating military commissions to try non-citizen terrorism suspects, we have made shockingly little progress in resolving the myriad constitutional questions that such tribunals raise. What's more, these questions have only become that much more pressing over time, (1) as Congress has stepped in to provide the authorization that the Supreme Court in Hamdan found to be lacking (thereby squarely raising some of the underlying constitutional questions); (2) as the debate over whether civilian courts or military tribunals are a more appropriate forum for trying the so-called "9/11 defendants" has raged both in public circles and behind the scenes within the current Administration; (3) as the nominal defendants before the military commissions have languished in various states of legal limbo; and (4) most recently, as the Supreme Court has upheld Congress's power to broadly prohibit the provision of "material support" to designated foreign terrorist organizations, an offense that Congress has also made triable before a military commission. To put it succinctly, it is impossible to have a meaningful debate over whether civilian courts or military commissions are a more appropriate forum for trying terrorism suspects so long as serious questions remain over whether the commissions may constitutionally exercise jurisdiction over particular offenses and/or offenders. And yet, although a number of defendants have attempted to challenge the jurisdiction of the military commissions - especially under the MCA - none of these cases have managed to produce a decision on the merits from any court higher than the Court for Military Commission Review (CMCR). Instead, the federal courts have generally relied on "abstention" doctrine, holding that challenges to the commissions, including to their jurisdiction, can - and should - be resolved on post-conviction appeal. That's not to say that the Article III courts won't have the last word; they may well, yet. But in the interim, the time has long since passed for a careful explication of the issues, the relevant precedents, and the most likely answers. This article attempts to provide a thorough introduction to - and analysis of - the constitutional limits on the jurisdiction of military commissions. By "jurisdiction," I mean two distinct types of authority: Jurisdiction over the offense, and jurisdiction over the offender. The former goes to whether the military court has the authority to try the charged offense; the latter goes to whether the military court has the authority to try the charged defendant. And whereas there are some precedents on the scope of these two species of jurisdiction in the context of military commissions, the law is far better settled in the closely analogous context of courts-martial, where similar issues routinely arise. Drawing on the court-martial decisions for support, this article concludes that the Constitution does meaningfully constrain the ability of Congress to subject particular offenders and offenses to trial by military commission. In particular, under the Supreme Court's own jurisprudence, the Constitution only authorizes the exercise of military jurisdiction over servicemembers or "offenses committed by enemy belligerents against the law of war." And although Congress is entitled to some latitude in giving content to the laws of war, there is simply no question that the constitutionality of the Military Commissions Acts of 2006 and 2009 is not settled by Congress's self-serving ipse dixit in each statute that all of the offenses are war crimes. Even if Article I tolerates such a naked arrogation of power, the jury-trial protections of Article III and the Fifth and Sixth Amendments do not - and never have.


A simple framework for understanding the U.S. legal profession is a gradual progression through three generations of lawyers: the generalist, the specialist, and the project manager. The transition from one generation to the next is driven by the familiar story of supply and demand. The generalist era (colonial period to the end of World War II) gave way to the specialist era (post-War to early 2000s) because of a shortage of sophisticated business lawyers capable of serving the needs of large, growing, and increasingly regulated industrial and financial clients. Over a period of several decades, leading local practitioners with business expertise transformed their small local practices into regional and national powerhouses. The common feature of all these transformations was an associate-partner training model, which enabled firms to build sufficient human capital to keep pace with -- and thus profit from -- the legal needs of their clients. In contrast, the U.S. legal profession is now in transition from the specialist to the project manager era. This era is driven by the need for clients to obtain more and better legal work at a lower and more predictable cost. To keep pace with these new client needs (i.e., demands), lawyers working for large corporate clients will increasingly layer their specialized legal knowledge with the skills of the project manager. To the extent that outside lawyers and law firms resist this gravitational pull -- perhaps because they are too wedded to the success and prosperity of the specialist era -- they will lose their seat at the economic table. Thus, as the project manager era unfolds, old hierarchies in the U.S. legal profession will fall and new hierarchies will be created.


We consider the problem of verifying confluence and termination of conditionalterm rewriting systems (TRSs). For unconditional TRSs the critical pair lemmaholds which enables a finite test for confluence of (finite) terminating systems.And for ensuring termination of unconditional TRSs a couple of methods forconstructing appropiate well-founded term orderings are known. If however ter-mination is not guaranteed then proving confluence is much more difficult. Re-cently we have obtained some interesting results for unconditional TRSs whichprovide sufficient criteria for termination plus confluence in terms of restrictedtermination and confluence properties. In particular, we have shown that anyinnermost terminating and locally confluent overlay system is complete, i.e. ter-minating and confluent. Here we generalize our approach to the conditional caseand show how to solve the additional complications due to the presence of con-ditions in the rules. Our main result can be stated as follows: Any conditionalTRS which is an innermost terminating semantical overlay system such that all(conditional) critical pairs are joinable is complete.


Over the last three decades researchers of Cognitive Metaphor Theory have shown conclusively that metaphor is motivated rather than arbitrary and often used to systematically map out conceptual territory. This cognitive semantic proposal holds the potential for alternative L2 teaching strategies. As an abstract domain, business discourse is naturally rich in metaphors and is additionally filled with consciously used metaphorical language to strategically manipulate clients and business partners. Business English courses especially stand to profit from metaphor-oriented language teaching, as (future) managers aim to quickly improve their language performance to be prepared for international business communication. In using metaphors, speakers as well as hearers conceptualize and thus experience one thing in terms of another. Having been made aware of the conceptual linkage, students are immediately equipped with a whole set of vocabulary they may already have learned for a concrete domain and are then able to elaborate in the more abstract area of business discourse. Enhanced metaphor awareness may thus prove to be a valuable vehicle for vocabulary acquisition as well as for vocabulary retention. This thesis is subdivided into ten chapters. With each successive chapter, the focus will increasingly sharpen on the main hypothesis that metaphor awareness raising and explicit teaching in the business English classroom assists the students to dip into their savings' and transfer already acquired vocabulary to abstract business discourse and thus to become more proficient business communicators. After an introduction to the main objectives, chapter two critically looks at the different strands of Cognitive Linguistic contributions to metaphor theory made within the last three decades and discusses the structure, function and processing of figurative language to single out relevant aspects of the language classroom applications. Chapter three narrows the perspective to the socio-economic discourse as the very target domain in focus and surveys the conceptual metaphors that have been identified for this target domain, namely the source domains most productive for the target and therefore most valuable for the language classroom. In chapter four Cognitive Linguistic findings are put in contact with language didactics; i.e., the Cognitive Linguistic basis is discussed in the context of language teaching and learning theories and a first classification of metaphor teaching in the theoretical framework of language didactics is proposed. Ten cornerstones summarize the theoretical output of the previous chapters and the respective didactic consequences are considered. Theories of cognitive psychology pertaining to noticing, processing, and storing metaphors are systematically revisited and expanded to formulate further didactic implications for metaphor teaching. The consequences drawn from both linguistic as well as didactic theory are translated into a list of ten short guidelines identifying essentials for the explicit integration of metaphors into the language classroom. In chapter five those experimental studies that have already been conducted in the field of Cognitive Linguistic-inspired figurative language teaching are systematically summarized and possible contributions to set up a didactic framework for metaphor teaching are investigated. Chapters six to nine then present a piece of original research. Starting out from five research questions tackling receptive and productive vocabulary acquisition and retention as well as the influence of and on the learner- level of language proficiency, a three-fold study was designed and conducted in a regular business English classroom and results are discussed in detail. The last chapter deals again with specific implications for teaching. Earlier statements about and claims for the language classroom are revisited and refined on the basis of the theoretical linguistic, didactic and empirical findings, and an agenda for further empirical investigations is sketched out.


Born in Italy, University of Chicago economist Luigi Zingales witnessed firsthand the consequences of high inflation and unemployment--paired with rampant nepotism and cronyism--on a country's economy. This experience profoundly shaped his professional interests, and in 1988 he arrived in the United States, armed with a political passion and the belief that economists should not merely interpret the world, but should change it for the better. In A Capitalism for the People, Zingales makes a forceful, philosophical, and at times personal argument that the roots of American capitalism are dying, and that the result is a drift toward the more corrupt systems found throughout Europe and much of the rest of the world. American capitalism, according to Zingales, grew in a unique incubator that provided it with a distinct flavor of competitiveness, a meritocratic nature that fostered trust in markets and a faith in mobility. Lately, however, that trust has been eroded by a betrayal of our pro-business elites, whose lobbying has come to dictate the market rather than be subject to it, and this betrayal has taken place with the complicity of our intellectual class. Because of this trend, much of the country is questioning--often with great anger--whether the system that has for so long buoyed their hopes has now betrayed them once and for all. What we are left with is either anti-market pitchfork populism or pro-business technocratic insularity. Neither of these options presents a way to preserve what the author calls "the lighthouse" of American capitalism. Zingales argues that the way forward is pro-market populism, a fostering of truly free and open competition for the good of the people--not for the good of big business. Drawing on the historical record of American populism at the turn of the twentieth century, Zingales illustrates how our current circumstances aren't all that different. People in the middle and at the bottom are getting squeezed, while people at the top are only growing richer. The solutions now, as then, are reforms to economic policy that level the playing field. Reforms that may be anti-business (specifically anti-big business), but are squarely pro-market. The question is whether we can once again muster the courage to confront the powers that be.


There is a dearth of studies on mood and modality as a focus. This study examines the manifestation of mood and modality in texts. It identifies their pattern of occurrence, compares their frequency, and accounts for possible differences between their manifestation and reported norms. The data comprise 3 069 verbal groups. It was obtained by orthographically transcribing Christian Religious Knowledge, Geography, Physics, and Chemistry lessons recorded in schools in Lagos State, Nigeria and identifying all the verbal groups therein. The topics taught were respectively The Mission of the Church, The Drainage System, Electric Field, and Nitrogen. The scale-and-category version of the systemic grammatical model, complemented by simple percentages, served as analytical tool. Results show that mood represents 72 per cent of the data and 81 per cent of the finite verbal groups. Declarative mood, interrogative mood and imperative mood represent 55 and 62, 10 and 11, and 7.4 and 8.3 per cent respectively of the data and finite. Verbal groups marked for imperative mood occurred most frequently in segments of the Physics lesson involving strict computation. The non-polar interrogative mood dominated (73 per cent) its polar counterpart. Modality accounted for 13 per cent of the data and 14 per cent of finite. Root modality and Epistemic modality manifested at a ratio of 3:2 in favour of Root meaning. Only in Physics was Epistemic modality (63 per cent )higher than Root meaning. Will and can exceeded the reported 4.2 and 3.5 in 1 000 word-occurrence by 67 and 46 per cent respectively. PREDICTION was the most recurring specific modal meaning. The fact that every verbal group in predicator function selects from the system of mood partly explains mood's dominance over modality in the texts analysed.


Folksonomies are Web 2.0 platforms where users share resources with each other. Furthermore, they can assign keywords (called tags) to the resources for categorizing and organizing the resources. Numerous types of resources like websites (Delicious), images (Flickr), and videos (YouTube) are supported by different folksonomies. The folksonomies are easy to use and thus attract the attention of millions of users. Together with the ease they offer, there are also some problems. This thesis addresses different problems of folksonomies and proposes solutions for these problems. The first problem occurs when users search for relevant resources in folksonomies. Often, the users are not able to find all relevant resources because they don't know which tags are relevant. The second problem is assigning tags to resources. Although many folksonomies (like Delicious) recommend tags for the resources, other folksonomies (like Flickr) do not recommend any tags. Tag recommendation helps the users to easily tag their resources. The third problem is that tags and resources are lacking semantics. This leads for example to ambiguous tags. The tags are lacking semantics because they are freely chosen keywords. The automatic identification of the semantics of tags and resources helps in reducing problems that arise from this freedom of the users in choosing the tags. This thesis proposes methods which exploit semantics to address the problems of search, tag recommendation, and the identification of tag semantics. The semantics are discovered from a variety of sources. In this thesis, we exploit web search engines, online social communities and the co-occurrences of tags as sources of semantics. Using different sources for discovering semantics reduces the efforts to build systems which solve the problems mentioned earlier. This thesis evaluates the proposed methods on a large scale data set. The evaluation results suggest that it is possible to exploit the semantics for improving search, recommendation of tags, and automatic identification of the semantics of tags and resources.


This Symposium Essay considers the impact of the Supreme Court's 2008 decision in Exxon Shipping Company v. Baker on the ability of juries to award punitive damages in a manner that comports with the law. In that case, the Court continued its two-decade crusade to place federal limits on punitive damages awards. The Exxon case was a federal maritime case arising out of the 1989 grounding of the Exxon Valdez in Prince William Sound, Alaska, resulting in arguably the biggest environmental disaster in U.S. history. In its decision, the Court for the first time identified "unpredictability" as the fundamental problem with punitive damages today. It then set out to make those damages more predictable by reaffirming the need for very low ratios, in this case 1:1, between punitive damages and compensatory damages. In this Essay, I argue that the Court's quest for predictability has resulted in reviewing courts being forced to rely too heavily on the facts of other cases involving similar claims in order to determine if the punitive damages award in the case at bar is constitutional. Such a system is fraught with error and, more importantly, creates a situation where juries cannot possibly render punitive damages verdicts that meet due process requirements because the very evidence they need to assess predictability – the facts and damage awards in other cases – cannot be made available to them. Part I provides a brief discussion of punitive damages generally and the Court's recent effort to place federal constitutional limits on those damages. Part II discusses the Exxon case itself and highlights the Court's focus on "unpredictability" as the fundamental problem with punitive damages. Part III shows how lower courts have applied the Exxon case. This Part reveals that even though courts recognize that the Exxon case is a federal maritime case rather than a substantive due process case, courts have embraced the call for predictable awards by ensuring punitive damages awards are in line (both as a matter of ratio and as an absolute dollar amount) with other similar cases. Part IV illustrates how the quest for predictability requires information on other similar cases that cannot be given to juries, and how the premium now placed on predictable damages awards makes it difficult, if not impossible, for juries to arrive at constitutional verdicts.


Tissue trauma is associated with marked increases in inflammatory cytokines. Increased inflammatory cytokines have been detected in the blood after high intensity eccentric exercise and long duration aerobic exercise. The source of the increased inflammatory cytokines is not entirely clear, but increased levels of inflammatory cytokine mRNA has been detected in the skeletal muscle tissue in response to high-intensity exercise; thus implicating skeletal muscle as a potential source for the production of inflammatory cytokines in response to exercise. Microdialysis is a powerful technique that uses a small tube with a semi-permeable membrane to allow for the collection of tissue interstitial fluid sample. The purpose of this study was to determine whether an acute bout of high-intensity resistance exercise increases inflammatory cytokines in the skeletal muscle interstitium and to gain a better understanding as to the source of where the inflammatory cytokines are derived. Microdialysis probes were inserted in the vastus lateralis and blood samples were collected via venipuncture. Increases in inflammatory cytokines were detected in the interstitial fluid prior to increases in the blood; however, in general there were no differences between the trials. The results suggest that inflammatory cytokines are derived in and released from skeletal muscle.