Leading theories of the Eleventh Amendment start from the premise that its text makes no sense. These theories regard the Amendment as either under-inclusive, over-inclusive, or an incoherent compromise because it prohibits federal courts from hearing "any suit" against a state by out-of-state citizens, but does not prohibit suits against a state by its own citizens. Two of these theories would either expand or contract the immunity conferred by the text of the Amendment in order to avoid this absurd or anomalous result. This Article suggests that the Eleventh Amendment made sense as written when understood in its full historical context. In particular, the Articles of Confederation empowered Congress to require states to supply men, money, and supplies, but gave Congress no power to enforce its own commands. Prominent Founders initially argued that the only way to fix the Articles was to give Congress coercive power over states. But the Convention, and the ratifiers, ultimately rejected this idea because they feared that the introduction of such power would lead to a civil war. To avoid this danger, the Founders designed the Constitution to give Congress legislative power over individuals rather than states. This novel approach eliminated the need for coercive power over states, and provided Federalists with a key argument for adopting the Constitution rather than amending the Articles. Anti-federalists threatened to undermine this case for the Constitution by arguing that the state-citizen diversity provisions of Article III - authorizing suits "between" states and out-of-state citizens - could be construed to permit suits against states (and thus imply federal power to enforce any resulting judgments against states). Although Federalists denied this construction, the Supreme Court proceeded to read Article III to permit out-of-state citizens to sue states. Federalists and Anti-federalists quickly joined forces to restore their preferred construction of Article III. In adopting the Eleventh Amendment, they saw no anomaly in prohibiting "any suit" against a state by out-of-state citizens because they did not understand the Constitution to authorize any suits against states by in-state citizens. Federal question jurisdiction did not expressly authorize such suits, and the Founders likely would not have perceived any real need for such jurisdiction given their understanding that the Constitution conferred neither legislative nor coercive power over states. Because the Eleventh Amendment, as written, made sense in light of the nature of the Union, the absurdity doctrine cannot justify departing from the terms of the Amendment.


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We believe that the appropriate characterization of when a language is a DSL, and when it is not, is best made through examination of the relative assignment of resources to a project. We present a new approach to the construction of text transform tools for the prodution of DSLs, and some constraints which shape this approach; not an examination of a specific implementation or architecture. We emphasize the use of ubiquitous tools to do transforms. A reader with concrete experience in some lexer and some parser generation packages, and some XML library with XSLT features, should be able to produce a tool using this approach in a day or two. The presentation is at a high enough level that the reader without this concrete and immediately applicable knowledge can still follow the approach. The goal is to make the production of small domain-specific languages common by promoting simplicity of implementation and use of the tools at hand. We use as an example the development of a parser for a simple parenthesis language. We also present a novel way of dealing with delimited lists in a parser specifica-


This paper presents extensive {bias determination} analyses of ozone observations from the Atmospheric Chemistry Experiment (ACE) satellite instruments: the ACE Fourier Transform Spectrometer (ACE-FTS) and the Measurement of Aerosol Extinction in the Stratosphere and Troposphere Retrieved by Occultation (ACE-MAESTRO) instrument. Here we compare the latest ozone data products from ACE-FTS and ACE-MAESTRO with coincident observations from nearly 20 satellite-borne, airborne, balloon-borne and ground-based instruments, by analysing volume mixing ratio profiles and partial column densities. The ACE-FTS version 2.2 Ozone Update product reports more ozone than most correlative measurements from the upper troposphere to the lower mesosphere. At altitude levels from 16 to 44 km, the average values of the mean relative differences are nearly all within +1 to +8%. At higher altitudes (45–60 km), the ACE-FTS ozone amounts are significantly larger than those of the comparison instruments, with mean relative differences of up to +40% (about +20% on average). For the ACE-MAESTRO version 1.2 ozone data product, mean relative differences are within ±10% (average values within ±6%) between 18 and 40 km for both the sunrise and sunset measurements. At higher altitudes (~35–55 km), systematic biases of opposite sign are found between the ACE-MAESTRO sunrise and sunset observations. While ozone amounts derived from the ACE-MAESTRO sunrise occultation data are often smaller than the coincident observations (with mean relative differences down to −10%), the sunset occultation profiles for ACE-MAESTRO show results that are qualitatively similar to ACE-FTS, indicating a large positive bias (mean relative differences within +10 to +30%) in the 45–55 km altitude range. In contrast, there is no significant systematic difference in bias found for the ACE-FTS sunrise and sunset measurements.


Based on the recent demonstration of elevated serum proinsulin levels in cystic fibrosis patients with impaired glucose tolerance, it was hypothesized that proinsulin could be an indicator of altered β-cell function. We therefore analyzed fasting proinsulin levels in 99 siblings of insulin-dependent diabetes mellitus (IDDM) patients, most of them discordant for diabetes for >6 yr. The results from this group were compared with the results from 41 healthy age- and sex-matched control subjects with no family history of diabetes. Median (range) fasting proinsulin in siblings was 8.9 pM (1.7–58 pM) vs. 3.8 pM (<1.2–28 pM) in control subjects (P < .00001). There was no difference between the groups in fasting blood glucose concentrations. Both groups had fasting insulin concentrations within the normal range with a tendency toward lower values in the siblings: 108 pM (60–237 pM) vs. 118 pM (71–175 pM) (P = .07). The 99 siblings were subdivided into groups according to HLA sharing with their diabetic proband. The concentration of proinsulin, insulin, and blood glucose among the groups of 33 HLA-identical, 40 HLA-haploidentical, and 26 nonidentical siblings did not differ significantly. The fasting proinsulin level did not correlate with fasting levels of insulin, blood glucose, age, or body weight. We conclude that fasting proinsulin is elevated in healthy siblings of IDDM patients, whereas fasting insulin is normal or slightly decreased independent of HLA identity with their diabetic sibling. Elevated proinsulin levels could represent a family trait, perhaps mirroring a β-cell more vulnerable to destruction, or it could reflect previous β-cell damage that does not lead to IDDM.


The Chinati Foundation is widely considered one of the world's most important destinations for experiencing large-scale contemporary art. It was founded by Donald Judd (1928-1994), whose specific ambition was to preserve and present a select number of permanent installations that were inextricably linked to the surrounding landscape. Chinati is located on 340 acres of desert on the site of former Fort D.A. Russell in Marfa, Texas. Construction and installation at the site began in 1979 with help from the Dia Art Foundation, and it was opened to the public in 1986. This handsome publication is the first comprehensive presentation of the Chinati Foundation's collection in more than twenty years. The book describes how Judd developed his ideas of the role of art and museums from the early 1960s onward, culminating in the creation of Chinati (and including its two predecessors-his buildings in New York and his residence in Marfa). The individual installations at Chinati are presented in chronological order with stunning photography; these include work by John Chamberlain, Dan Flavin, David Rabinowitch, Roni Horn, Ilya Kabakov, Richard Long, Carl Andre, Claes Oldenburg and Coosje Van Bruggen, as well as Judd himself. His installations at Marfa include 15 outdoor works in concrete and 100 aluminum pieces housed in two carefully renovated artillery sheds. The book also features writings by Judd relating to Chinati and Marfa, and a complete catalogue of the collection.


For a generation since Margaret Jane Radin's classic article Property and Personhood, scholars have viewed personhood as a conception of property that affirms autonomy, dignity, and basic civil rights, a progressive alternative to traditional, more economically focused property theories. This article presents a fundamental challenge to personhood as a progressive approach to property. It shows that personhood claims often derive from violent and other harmful acts committed in the course of acquiring and owning property. This persistent and pervasive connection between personhood and violence — the "atrocity value" in property — upends core assumptions about the American property tradition and complicates the progressive social function of property law. This article explains why atrocity creates entitlement, drawing from social psychology and accounts of law and violence to show how violence can foster personhood. The article then explores the deep historical roots of atrocity within the American property tradition, which helped establish an abiding cultural value that encouraged personal identification with property. Finally, the article surveys how atrocity continues to foster personhood in an array of contexts involving common ownership, exclusion, and use. Ultimately, personhood emerges less as a progressive value in property than as a challenge that the law has had to negotiate. Property law is often successful in promoting progressive and cooperative goals because courts do not attempt to decide cases on the basis of a personhood value in property.


This study examines how high school employment affects future economic attainment. There is no indication that light to moderate job commitments ever have a detrimental effect; instead, hours worked during the senior grade are positively correlated with future earnings, fringe benefits, and occupational status. These gains occur even though employed seniors attain slightly less education than their counterparts. The results are robust across a variety of specifications and suggest that student employment increases net investments in human capital particularly toward the end of high school and for females.


[1] We use observations from two aircraft during the ICARTT campaign over the eastern United States and North Atlantic during summer 2004, interpreted with a global 3-D model of tropospheric chemistry (GEOS-Chem) to test current understanding of regional sources, chemical evolution, and export of NOx. The boundary layer NOx data provide top-down verification of a 50% decrease in power plant and industry NOx emissions over the eastern United States between 1999 and 2004. Observed NOx concentrations at 8–12 km altitude were 0.55 ± 0.36 ppbv, much larger than in previous U.S. aircraft campaigns (ELCHEM, SUCCESS, SONEX) though consistent with data from the NOXAR program aboard commercial aircraft. We show that regional lightning is the dominant source of this upper tropospheric NOx and increases upper tropospheric ozone by 10 ppbv. Simulating ICARTT upper tropospheric NOx observations with GEOS-Chem requires a factor of 4 increase in modeled NOx yield per flash (to 500 mol/ flash). Observed OH concentrations were a factor of 2 lower than can be explained from current photochemical models, for reasons that are unclear. A NOy-CO correlation analysis of the fraction f of North American NOx emissions vented to the free troposphere as NOy (sum of NOx and its oxidation products) shows observed f = 16 ± 10% and modeled f = 14 ± 9%, consistent with previous studies. Export to the lower free troposphere is mostly HNO3 but at higher altitudes is mostly PAN. The model successfully simulates NOy export efficiency and speciation, supporting previous model estimates of a large U.S. anthropogenic contribution to global tropospheric ozone through PAN export.


As a student in the 1970s, Deborah Willis came to the realization that images of black beauty, female and male, simply did not exist in the larger culture. Determined to redress this imbalance, Willis examined everything from vintage ladies' journals to black newspapers, and started what would become a lifelong quest. With more than two hundred arresting images, many previously unpublished, Posing Beauty recovers a world many never knew existed. Historical subjects such as Billie Holiday and Josephine Baker illuminate the past; Angela Davis and Muhammad Ali take us to the civil rights era; Denzel Washington, Lil' Kim, and Michelle Obama celebrate the present. Featuring the works of more than one hundred photographers, including Carl van Vechten, Eve Arnold, Lee Friedlander, and Carrie Mae Weems, Willis's book not only celebrates the lives of the famous but also captures the barber shop, the bodybuilding contest, and prom night. Posing Beauty challenges our most fundamental assumptions about what it means to be "beautiful."


The world's leading economies are facing not just one but many crises. The financial meltdown may not be over, climate change threatens major global disruption, economic inequality has reached extremes not seen for a century, and government and business are widely distrusted. At the same time, many people regret the consumerism and social corrosion of modern life. What these crises have in common, Diane Coyle argues, is a reckless disregard for the future--especially in the way the economy is run. How can we achieve the financial growth we need today without sacrificing a decent future for our children, our societies, and our planet? How can we realize what Coyle calls "the Economics of Enough"? Running the economy for tomorrow as well as today will require a wide range of policy changes. The top priority must be ensuring that we get a true picture of long-term economic prospects, with the development of official statistics on national wealth in its broadest sense, including natural and human resources. Saving and investment will need to be encouraged over current consumption. Above all, governments will need to engage citizens in a process of debate about the difficult choices that lie ahead and rebuild a shared commitment to the future of our societies. Creating a sustainable economy--having enough to be happy without cheating the future--won't be easy. But The Economics of Enough starts a profoundly important conversation about how we can begin--and the first steps we need to take.


Dramatic and controversial changes in the funding of science over the past two decades, towards its increasing commercialization, have stimulated a huge literature trying to set out an "economics of science". Whether broadly in favour or against these changes, the vast majority of these frameworks employ ahistorical analyses that cannot conceptualise, let alone address, the questions of "why have these changes occurred?" and "why now?" Nor, therefore, can they offer much insight into the crucial question of future trends. Given the growing importance of science and innovation in an age of both a globalizing knowledge-based economy (itself in crisis) and enormous challenges that demand scientific and technological responses, these are significant gaps in our understanding of important contemporary social processes. This book argues that the fundamental underlying problem in all cases is the ontological shallowness of these theories, which can only be remedied by attention to ontological presuppositions. Conversely, a critical realist approach affords the integration of a realist political economy into the analysis of the economics of science that does afford explicit attention to these crucial questions; a 'cultural political economy of research and innovation' (CPERI). Accordingly, the book sets out an introduction to the existing literature on the economics of science together with novel discussion of the field from a critical realist perspective. In arguing thus across levels of abstraction, however, the book also explores how concerted engagement with substantive social enquiry and theoretical debate develops and strengthens critical realism as a philosophical project, rather than simply 'applying' it. While the first of these two volumes argues how mainstream economics is inadequate to the task of an explanatory and critical 'economics of science', the challenge in this second volume is to examine the strengths and weaknesses of disciplines offering more promising starting points. Two social scientific disciplines are particularly promising candidates, starting from 'economy' or 'science', namely heterodox political economy and science & technology studies respectively. Synthesising these into an 'economics of science', however, still encounters considerable hurdles, in that there remain some fundamental and mutual philosophical incompatibilities. Formulating an 'economics of science' thus demands that both 'economics' and 'science' be redefined. The book explores how a critical realist approach affords some common ground upon which this productive synthesis may be pursued, in the form of a cultural political economy of research and innovation (CPERI).


"The current study explores the relationship between child care program administration, organizational climate, and global quality. The newly developed Program Administration Scale (PAS; Talan & Bloom, 2005) was utilized in the study. Both program administration and organizational climate were found to be positively correlated with preschool classroom global quality. There was a significant relationship between organizational climate and a language/interaction factor of the ECERS-R. Director education was related to higher quality administrative practices and not-for-profit centers scored significantly better than for-profit centers. Additionally, a relationship between the PAS and the Parents and Staff Subscale was found. Based on this finding, it is recommended that research and Quality Rating Systems using the Environment Rating Scales incorporate the Parents and Staff Subscale in final scores. Discussion including policy implications of the current findings and future research is included."--Abstract from author supplied metadata.


Over the past several years, metamaterials have been introduced and rapidly been adopted as a means of achieving unique electromagnetic material response. In metamaterials, artificially structured—often periodically positioned—inclusions replace the atoms and molecules of conventional materials. The scale of these inclusions is smaller than that of the electromagnetic wavelength of interest, so that a homogenized description applies. We present a homogenization technique in which macroscopic fields are determined via averaging the local fields obtained from a full-wave electromagnetic simulation or analytical calculation. The field-averaging method can be applied to homogenize any periodic structure with unit cells having inclusions of arbitrary geometry and material. By analyzing the dispersion diagrams and retrieved parameters found by field averaging, we review the properties of several basic metamaterial structures. © 2006 Optical Society of America OCIS codes: 160.0160, 160.1190, 260.2110, 350.5500.


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The objective of the study was to determine the effect of season on faecal egg counts and biochemical profiles in indigenous Nguni goats of South Africa. Body weights, body condition scores, faecal and blood samples were collected from 96 goats. Faecal samples were analysed for nematodes and trematodes. Blood was analysed for packed cell volume (PCV), glucose, cholesterol, total protein, albumin, globulin, urea and creatinine. Significantly higher total protein and globulin values were recorded in the wet than the dry season. A significant positive correlation was recorded between body condition scores and albumin concentrations. Season had an effect on glucose, globulin, TP, creatinine, PCV and FEC of Nguni goats. It, therefore, is imperative to put measures in place to counteract the drop in any of these parameters, with season, if productivity of the indigenous goats is to be maintained. Further studies are required to determine the parasites causing chronic health challenges that were evidenced by elevated globulin concentrations in the flock studied. Since the high globulin levels were not accompanied by clinical cases, the reference levels used might be inappropriate for the indigenous Nguni goats.


Despite the growing popularity of mindfulness and acceptance-based performance enhancement methods in applied sport psychology, evidence for their efficacy is scarce. The purpose of the current study is to test the feasibility and effect of a psychological training program based on Acceptance and Commitment Training (ACT) developed for ice hockey players. A controlled group feasibility designed study was conducted and included 21 elite male ice hockey players. The ACT program consisted of four, once a week, sessions with homework assignments between sessions. The results showed significant increase in psychological flexibility for the players in the training group. The outcome was positive for all feasibility measures. Participants found the psychological training program important to them as ice hockey players and helpful in their ice hockey development. Desirably, future studies should include objective performance data as outcome measure to foster more valid evidence for performance enhancement methods in applied sport psychology.


Nineteen occurrences of interspecific sexual behavior between male southern sea otters (Enhydra lutris nereis) and juvenile Pacific harbor seals (Phoca vitulina richardsi) were reported in Monterey Bay, California, between 2000 and 2002. At least three different male sea otters were observed harassing, dragging, guarding, and copulating with harbor seals for up to 7 d postmortem. Carcasses of 15 juvenile harbor seals were recovered, and seven were necropsied in detail by a veterinary pathologist. Necropsy findings from two female sea otters that were recovered dead from male sea otters exhibiting similar behavior are also presented to facilitate a comparison of lesions. The most frequent lesions included superficial skin lacerations; hemorrhage around the nose, eyes, flippers, and perineum; and traumatic corneal erosions or ulcers. The harbor seals sustained severe genital trauma, ranging from vaginal perforation to vagino-cervical transection, and colorectal perforations as a result of penile penetration. One harbor seal developed severe pneumoperitoneum subsequent to vaginal perforation, which was also observed in both female sea otters and has been reported as a postcoital lesion in humans. This study represents the first description of lesions resulting from forced copulation of harbor seals by sea otters and is also the first report of pneumoperitoneum secondary to forced copulation in a nonhuman animal. Possible explanations for this behavior are discussed in the context of sea otter biology and population demographics.


Adaptivity is prevalent in today's software. Mobile devices self-adapt to available network connections, washing machines adapt to the amount of laundry, etc. Current approaches for engineering such systems facilitate the specification of adaptivity in the analysis and the technical design. However, the modeling of platform independent models for adaptivity in the logical design phase remains rather neglected causing a gap between the analysis and the technical design phase.
 To overcome this situation, we propose an approach called Adapt Cases. Adapt Cases allow the explicit modeling of adaptivity with domain-specific means, enabling adaptivity to gather attention early in the software engineering process. Since our approach is based on the concept of use cases it is easy adoptable in new and even running projects that use the UML as a specification language, and additionally, can be easily incorporated into model-based development environments.


Quality knives are typically fabricated from high-strength steel alloys. Depending on the application, there are different requirements for mechanical and physical properties that cause problems for steel alloys. For example, diver's knives are generally used in salt water, which causes rust in steel knives. Titanium diver's knives are a popular alternative due to their salt water corrosion resistance, but are too soft to maintain a sharp cutting edge. Steel knives are also magnetic, which is undesirable for military applications where the knives are used as a tactical tool for diffusing magnetic mines. Steel is also significantly denser than titanium (8 g/cu cm vs. 4.5 g/cu cm), which results in heavier knives for the same size. Steel is hard and wear-resistant, compared with titanium, and can keep a sharp edge during service. A major drawback of both steel and titanium knives is that they must be ground or machined into the final knife shape from a billet. Since most knives have a mirrored surface and a complex shape, manufacturing them is complex. It would be more desirable if the knife could be cast into a net or near-net shape in a single step. The solution to the deficiencies of titanium, steel, and ceramic knives is to fabricate them using bulk metallic glasses (or composites). These alloys can be cast into net or near-net shaped knives with a combination of properties that exceed both titanium and steel. A commercially viable BMG (bulk metallic glass) or composite knife is one that exhibits one or all of the following properties: It is based on titanium, has a self-sharpening edge, can retain an edge during service, is hard, is non-magnetic, is corrosion-resistant against a variety of corrosive environments, is tough (to allow for prying), can be cast into a net-shape with a mirror finish and a complex shape, has excellent wear resistance, and is low-density. These properties can be achieved in BMG and composites through alloy chemistry and processing. For each desired property for knife fabrication and performance, there is an alloy development strategy that optimizes behavior. Although BMG knives have been demonstrated as far back as 1995, they never found commercial success because they had to be ground (which presented problems because the alloys contained beryllium), they weren't low cost (because they weren't cast to a net-shape), they were brittle (because they were made with a low-quality commercial material), and they had extremely poor corrosion resistance (because corrosion was not well-understood in these materials). Ultimately, these shortcomings prevented the widespread commercialization. In the current work, the inventors have applied more than a decade of research on BMGs from Caltech and JPL to develop a better understanding of how to make BMG knives that exhibit an optimal combination of properties, processing and cost. Alloys have been developed based in titanium (and other metals), that exhibit high toughness, high hardness, excellent corrosion resistance, no ferromagnetism, edge-retaining selfsharpening, and the ability to be cast like a plastic using commercially available casting techniques (currently used by commercial companies such as Liquidmetal Technologies and Visser Precision Casting). The inventors argue that depending on the application (diving, military, tactical, utility, etc.) there is an optimal combination of design and alloy composition. Moreover, with new casting technologies not available at the inception of these materials, net-shaped knives can be cast into complex shapes that require no aftermarket forming, except for sharpening using water-cooled polishing wheel. These combinations of discoveries seek to make low-cost BMG knives commercially viable products that have no equal among metal or ceramic knives. Current work at JPL focuses on net-shape casting of these alloys and testing their mechanical properties versus commercially available knives to demonstrate their benefits.


The matrix formalism is applied to describe various stratified and periodic systems that are used to couple optical energy into a dielectric film or medium. As the literature is often presenting cases for the transverse electric wave ( TE ), general analytical and numerical solutions are reviewed for many types of optical thin film systems with some emphasis on the transverse magnetic ( TM ) wave. This manuscript is divided into two main parts. In the first part, we look at stratified systems formed by a succession of multilayers and also present some applications for this type of optical systems such as bi-layer dielectric stacks. Tunneling across an air gap formed by two prisms' long sides brought close to each other is also presented. Tunneling modes in optical system is reviewed in detail in systems that are probing an optical waveguide layer. In the second part of this manuscript, we are looking at optical systems in which a corrugated surface is used to couple energy into a medium. The matrix formalism used in this second part is applied mostly to grating waveguide structures and used in numerical computation of diffraction efficiencies ( DE ). Binary dielectric and metallic grating are also introduced with some emphasis on general ideas leading to the origin of photonic band-gap. This manuscript is reviewing various applications involving the matrix method supported by some results, but is also meant to be an overview with the main emphasis on optical thin film system grating waveguide structures.


Many formal descriptions of DPLL-based SAT algorithms either do not include all essential proof techniques applied by modern SAT solvers or are bound to particular heuristics or data structures. This makes it dicult to analyze proof-theoretic properties or the search complexity of these algorithms. In this paper we try to improve this situation by developing a nondeterministic proof calculus that models the functioning of SAT algorithms based on the DPLL calculus with clause learning. This calculus is independent of implementation details yet precise enough to enable a formal analysis of realistic DPLL-based SAT algorithms.


Copyright is undoubtedly a very complicated matter. For that very reason it might be useful now and again to look beyond the jungle of treaties, directives, laws, decrees and contracts, and try to establish where we are actually heading. Then we can ask ourselves whether the direction taken is the one we would like to see. My purpose in writing this article is to demonstrate how the 'balance', which was always considered to be a crucial goal of copyright regulation, has been gradually undermined, to the detriment of the consumers of information and culture. I will also try to illustrate how copyright has become distanced from what was once its very foundations. If we look more closely at recent developments there are primarily two factors which merit special attention, namely 1) the widespread revision of copyright legislation and 2) The increasing regulation by contract.


The importance of narrative for practical theology is today widely recognised, both nationally and internationally. There is, however, disagreement amongst practical theologians regarding the scope and role of narrative in practical theological methodology. The practical theologian Julian Muller made, and continues to make, an important contribution to the methodology of practical theology through his narrative approach. The aim of this article was to contribute to the ongoing methodological discussion about the scope and role of narrative approaches in practical theology. Muller's narrative approach was discussed against the backdrop of the narrative turn in the human and social sciences. It was concluded that Muller's narrative approach reveals some of the key tensions in practical theological methodology. His metaphorical narrative approach, as a representative of the poetic pole in the methodological debate, helps to guard practical theology from losing its transformative orientation and its vital connection with religious practice. Embracing a variety of approaches could help practical theologians to steer between the Scylla of a one-sidedly scientific practical theology and the Charybdis of the triumph of the immediacy of praxis.


Novel Drug Preventing Protein Recycling Shows Potential for Treating Leukemia MD Anderson Cancer Center first to test drug in acute leukemia models Researchers from the Children's Cancer Hospital at The University of Texas MD Anderson Cancer Center have found that a novel targeted therapy effectively treats acute leukemia in animal models by preventing cancer cells from being purged of damaged proteins. In the March 2007 online issue of the journal Blood, investigators reported that the new proteasome inhibitor, NPI-0052, not only successfully kills leukemia cells, but also shows greater efficacy than its predecessor bortezomib when combined with other agents in animal models. According to researchers, proteasomes clean out mutated or damaged proteins within cells, which promotes cell growth and allows cancer cells to rapidly reproduce. Proteasome inhibitors block this process, resulting in apoptosis, or cell death, of the malignant cells. Bortezomib is the first and only FDA-approved proteasome inhibitor. Although it is effective for treating multiple myeloma and mantle cell lymphoma, it was proven to be ineffective as a single agent against leukemia in clinical trials. NPI-0052 varies from bortezomib in ways that researchers at M. D. Anderson hope will make NPI-0052 effective in a human clinical trial. "NPI-0052 targets the proteasome through different intermediaries and is more potent than bortezomib in leukemia cells," says senior author Joya Chandra, Ph.D., assistant professor of pediatrics from the Children's Cancer Hospital at MD Anderson. "Therefore we can use less of the drug to inhibit the proteasome." NPI-0052 inhibits the main enzymatic activity of the proteasome three times more effectively than bortezomib as a single agent. When combined with a histone deacetylase (HDAC) inhibitor, another anti-cancer agent, NPI-0052 achieves four-fold greater synergistic effects than bortezomib. MD Anderson currently has a Phase I clinical trial led by principal investigator Razelle Kurzrock, M.D., to test NPI-0052 on adult patients with solid tumor malignancies and recurrent lymphoma. Chandra's group is the first group to be studying the effects of the drug in acute leukemia models. "This drug, so far, has shown efficacy in animal models of leukemia, myeloma and colon cancer, and it has worked to kill multiple myeloma cells resistant to bortezomib," says Chandra. "As a result of our research, we're looking at the feasibility of combining NPI-0052 with HDAC inhibitors in the future to treat leukemia." Chandra's lab has received funding from the National Cancer Institute Leukemia SPORE grant awarded to MD Anderson and from an NCI training grant to graduate student, Claudia Miller. Co-authors on the project are first author Claudia Miller, Kechen Ban, Ph.D., and Melanie Dujka from the Department of Pediatrics Research; David McConkey, Ph.D., from the Department of Cancer Biology; Mark Munsell from the Division of Quantitative Sciences, all at M. D. Anderson Cancer Center; and Michael Palladino, Ph.D., from Nereus Pharmaceuticals.


Exploratory data analysis is a process of sifting through data in search of interesting information or patterns. Analysts' current tools for exploring data include database management systems, statistical analysis packages, data mining tools, visualization tools, and report generators. Since the exploration process seeks the unexpected in a data-driven manner, it is crucial that these tools are seamlessly integrated so analysts can flexibly select and compose tools to use at each stage of analysis. Few systems have integrated all these capabilities either architecturally or at the user interface level. Visage's information-centric approach allows coordination among multiple application user interfaces. It uses an architecture that keeps track of the mapping of visual objects to information in shared databases. One result is the ability to perform direct manipulation operations such as drag-and-drop transfer of data among applications. This paper describes Visage's Visual Query Language and visualization tools, and illustrates their application to several stages of the exploration process: creating the target dataset, data cleaning and preprocessing, data reduction and projection, and visualization of the reduced data. Unlike previous integrated KDD systems' interfaces, direct manipulation is used pervasively, and the visualizations are more diverse and can be customized automatically as needed. Coordination among all interface objects simplifies iterative modification of decisions at any stage.


WHO BETTER TO FACE THE GREATEST EVIL OF THE 20TH CENTURY THAN A HUMBLE MAN OF FAITH? As Adolf Hitler and the Nazis seduced a nation, bullied a continent, and attempted to exterminate the Jews of Europe, a small number of dissidents and saboteurs worked to dismantle the Third Reich from the inside. One of these was Dietrich Bonhoeffer-a pastor and author, known as much for such spiritual classics as The cost of Discipleship and Life Together, as for his 1945 execution in a concentration camp for his part in the plot to assassinate Adolf Hitler. In the first major biography of Bonhoeffer in forty years, New York Times best-selling author Eric Metaxas takes both strands of Bonhoeffer's life?the theologian and the spy?to tell a searing story of incredible moral courage in the face of monstrous evil. In a deeply moving narrative, Metaxas uses previously unavailable documents?including personal letters, detailed journal entries, and firsthand personal accounts?to reveal dimensions of Bonhoeffer's life and theology never before seen. In Bonhoeffer: Pastor, Martyr, Prophet, Spy?A Righteous Gentiel vs the Third Reich, Metaxas presents the fullest accounting of Bonhoeffer's heart-wrenching 1939 decision to leave the safe haven of America for Hitler's Germany, and using extended excerpts from love letters and coded messages written to and from Bonhoeffer's Cell 92, Metaxas tells for the first time the full story of Bonhoeffer's passionate and tragic romance. Readers will discover fresh insights and revelations about his life-changing months at the Abyssinian Baptist Church in Harlem and about his radical position on why Christians are obliged to stand up for the Jews. Metaxas also sheds new light on Bonhoeffer's reaction to Kristallnacht, his involvement in the famous Valkyrie plot and in "Operation 7," the effort to smuggle Jews into neutral Switzerland. Bonhoeffer gives witness to one man's extraordinary faith and to the tortured fate of the nation he sought to deliver from the curse of Nazism. It brings the reader face to face with a man determined to do the will of God radically, courageously, and joyfully?even to the point of death. Bonhoeffer is the story of a life framed by a passion for truth and a commitment to justice on behalf of those who face implacable evil. "Insightful and illuminating, this tome makes a powerful contribution to biography, history and theology." ?Publishers Weekly "[A] massive and masterful new biography." ?Christianity Today "Metaxas tells Bonhoeffer's story with passion and theological sophistication." ?Wall Street Journal "Metaxas magnificently captures the life of theologian and anti-Nazi activist Dietrich Bonhoeffer ...A definitive Bonhoeffer biography for the 21st Century." ?Kirkus


A poem by E.Y. HarburgThis article can also be found at the Monthly Review website, where most recent articles are published in full.Click here to purchase a PDF version of this article at the Monthly Review website.


This volume offers the first comprehensive description of English imperatives made from a Cognitive Linguistic perspective. It proposes a new way of explaining the meaning and function of the imperative independently of illocutionary act classifications, which allows for quantifying the strength of imperative force in terms of parameters and numerical values. Furthermore, the book applies the theory of Construction Grammar to account for the felicity of imperatives in complex sentences. The model of description explains explicitly a wide range of phenomena, including frequency of use, prototypical vs. non-prototypical uses of the English imperative and the choice between longer vs. shorter directives including the imperative. A Cognitive Linguistic Analysis of the English Imperative: With Special Reference to Japanese Imperatives is intended for both researchers and students interested in the English imperative and Directive Speech Acts at large and for the linguists working within the Cognitive Linguistics and/or Construction Grammar approach.


In this paper the authors report the use of concept mapping as a means of summarizing interview transcripts in the study of the information-seeking behavior of employees in an organization. Concept mapping differs from traditional methods of textual coding for interview analysis by making underlying cognitive structures transparent and giving a focus to the sets of propositions by which individuals construct meaning. Concept map structure correlates with the perceived richness of interview data. They provide quick summaries of the interview quality and may help to identify topics for further probing to elicit new information. In this study rich interviews provide complex concept map structures, whereas less successful interviews provide simpler, spoke structures. Issues in using concept maps with research interviews are discussed, including use as a retrospective interview probe, as a check on evidence saturation, as a form of data display or as a form of creative coding.


Book synopsis: The Indian Ocean was global long before the Atlantic, and today the countries bordering the Bay of Bengal—India, Bangladesh, Burma, Sri Lanka, Thailand, and Malaysia—are home to one in four people on Earth. Crossing the Bay of Bengal places this region at the heart of world history for the first time. Integrating human and environmental history, and mining a wealth of sources, Sunil Amrith gives a revelatory and stirring new account of the Bay and those who have inhabited it.

For centuries the Bay of Bengal served as a maritime highway between India and China, and then as a battleground for European empires, all while being shaped by the monsoons and by human migration. Imperial powers in the nineteenth century, abetted by the force of capital and the power of steam, reconfigured the Bay in their quest for coffee, rice, and rubber. Millions of Indian migrants crossed the sea, bound by debt or spurred by drought, and filled with ambition. Booming port cities like Singapore and Penang became the most culturally diverse societies of their time. By the 1930s, however, economic, political, and environmental pressures began to erode the Bay's centuries-old patterns of interconnection.

Today, rising waters leave the Bay of Bengal's shores especially vulnerable to climate change, at the same time that its location makes it central to struggles over Asia's future. Amrith's evocative and compelling narrative of the region's pasts offers insights critical to understanding and confronting the many challenges facing Asia in the decades ahead.


Abstract In many countries, open and distance education is perceived as a way to meet the growing need for higher education. This paper explores the development of online and distance education in three countries that are still a white spot on the landscape of international distance education research although they have implemented elaborated distance education systems: Turkey, Russia and Saudi-Arabia. In order to understand the current state of distance education systems in the three countries, their respective systems are described from a historical perspective, compared in regard to their organization, important institutions for open and distance education and current developments. This comparative analysis directs the focus on little investigated education systems and contributes to an enhanced understanding of their past, present, and future.


The standard version of the Heckscher-Ohlin model of international trade treats the factors of production--land, labor, and capital--as essentially analytically similar and symmetrical. In these six essays Ronald Findlay explores modifications to the factor proportions model, looking in particular at what happens when human capital and land use are allowed to vary endogenously. Findlay extends the factor proportions theory of international trade to consider capital accumulation, income distribution, and factor mobility in a growing world economy. Among the questions he addresses are such fundamental issues as the conditions under which international trade equalizes the rate of interest; the effects of learning and invention on economic growth and comparative advantage; the role of human capital and skill formation in determining patterns of comparative advantage and the reciprocal effect of international trade on these variables through its impact on wage differentials between skilled and unskilled workers; the incorporation of new territories into a trading system by extensions of the frontier and labor migration as in the establishment of the Atlantic economy of the nineteenth century; and the impact of reductions in transport costs of industrial raw materials on global patterns of manufacturing activity and comparative advantage.


As a constitutional theorist, the late Judge Robert Bork was best known for his advocacy of two major ideas: originalism and judicial deference to the democratic process. In some cases, these two commitments may be mutually reinforcing. But Judge Bork largely failed to consider the possibility that his two ideals sometimes contradict each other. Yet it has become increasingly clear that consistent adherence to originalism would often require judges to impose more constraints on democratic government rather than fewer. The tension between democracy and originalism is an important challenge for Bork's constitutional thought, as well as that of other originalists who place a high value on democracy. We could call the trade-off between the two the "Borkean dilemma." Part I of this Essay briefly outlines Bork's well-known commitments to both originalism and judicial deference to the democratic process. Part II discusses his failure to resolve the potential contradiction between the two. In Part III, I explain why the tension between originalism and deference has become an increasingly serious problem for originalists and briefly consider some possible ways to resolve, or at least minimize, the contradiction. Some of these theories have potential, especially the idea that many types of judicial review might actually promote rather than undermine popular control of government. Ultimately, however, none of them comes close to fully resolving the conflict between originalism and democracy. The consistent originalist will likely have to accept substantial constraints on democracy. The consistent adherent of deference to the democratic process will have to reject judicial enforcement of major parts of the original meaning of the Constitution.


Increasing urbanisation and climate change belong to the greatest challenges of the 21st century. A high share of global greenhouse gas emissions are estimated to originate in urban areas (40 % to 78 % according to UN Habitat 2010). Therefore, low carbon city strategies and concepts implicate large greenhouse gas (GHG) mitigation potentials. At the same time, with high population and infrastructure densities as well as concentrated economic activities, cities are particularly vulnerable to the impacts of climate change and need to adapt. Scarce natural resources further constrain the leeway for long-term, sustainable urban development. The Low Carbon Future Cities (LCFC) project aims at tapping this three-dimensional challenge and will develop an integrated strategy / roadmap, balancing low carbon development, gains in resource efficiency and adaptation to climate change. The study focuses on two pilot regions - one in China (Wuxi) and one in Germany (Dusseldorf+) - and is conducted by a German-Chinese research team supported by the German Stiftung Mercator. The paper gives an overview of first outcomes of the analysis of the status quo and assessment of the most likely developments regarding GHG emissions, climate impacts and resource use in Wuxi. The project developed an emission inventory for Wuxi to identify key sectors for further analysis and low carbon scenarios. The future development of energy demand and related CO2 emissions in 2030 were simulated in the current policy scenario (CPS), using five different sub-models. Selected aspects of Wuxi's current material and water flows were analysed and modelled for energy transformation and the building sector. Current and future climate impacts and vulnerability were investigated. Recent climatic changes and resulting damages were analysed, expected changes in temperature and precipitation in the coming four decades were projected using ensembles of three General Circulation Models. Although Wuxi's government started a path to implement a low carbon plan, the first results show that more ambitious efforts are needed to overcome the challenges faced.


The ideal membership problem for the ring of multivariate polynomials is a central problem in Computational Algebra. Relatively tight computational complexity bounds for this problem are known in the case of polynomials with coefficients in a field. After reviewing these results we give an algorithm, together with an upper bound on its complexity, for the solution of the membership problem in the case of polynomials with integer coefficients. This result is obtained adapting Buchberger's algorithm to the integer case. As an application, we also provide a more general upper bound on the length of strictly ascending chain of ideals in the ring $Z\lbrack x\sb1,\...,x\sb{n}\rbrack.$
Many applications of Computational Algebra, however, do not require the complete solution of the membership problems and alternative approaches are available. In this thesis we survey the method of the characteristic sets, originally introduced by Ritt, in the forties, and now widely applied, particularly in Elementary Geometry Theorem Proving. We present optimal algorithms for computing a characteristic set with simple-exponential sequential and polynomial parallel time complexities.
We finally present an attempt to generalize some of the constructive methods of Commutative Algebra to the Algebra of differential polynomials. Rings of differential polynomials do not resemble their purely algebraic counterparts: we prove that there exist non-recursive differential ideals in $Z\{x\}$ and hence that, in general, no effective method can be devised to solve the membership problem in this case. However special classes of ideals can be algorithmically approached and toward this goal, we generalize the concept of H-basis, first introduced by Macaulay for algebraic ideals, to differential rings.


Within the context of health and social care education, attempts to define 'scholarship' have increasingly transcended traditional academic conceptions of the term. While acknowledging that many applied disciplines call for a kind of 'actionable knowledge' that is also not separate from its ethical dimensions, engagement in the caring professions in particular provides an interesting exemplar that raises questions about the nature and practice of 'actionable knowledge': how is such knowledge from different domains (the head, hand and heart) integrated and sustained? This paper is theoretical and wishes to outline some philosophical ideas that may be important when considering the characteristics of the kind of scholarship for caring practices that draw on deep resources for creativity and integration. Firstly, there is an attempt to clarify the nature of scholarly practice by drawing on Aristotle's notion of 'phronesis' (practical wisdom). Secondly, a more meditative approach to the integration of knowledge, action and ethics is highlighted. Finally, its implications for scholarship are introduced, in which scholarly integration may best be served by more contemplative ways of being and thinking. Drawing on Heidegger and Gendlin, we consider the challenges of contemplative thinking for pursuing scholarly practice. We articulate contemplative thinking as an unspecialized mode of being that is given to human beings as an intimate source of creativity. The sense in which unspecialization can be cultivated and practised is discussed.


Abstract
This bachelor thesis delivers a comprehensive overview of the topic Internet of Things (IoT). With the help of a first literature review, important characteristics, architectures, and properties have been identified. The main aim of this bachelor thesis is to determine whether the use of IoT in the transport of food, considering the compliance with the cold chain, can provide advantages for companies to reduce food waste. For this purpose, a second literature review has been carried out with food transport systems without the use, as well as with the use of IoT. Based on the literature review, it is possible at the end to determine a theoretical 'ideal' system for food transport in refrigerated trucks. The respective used technologies are also mentioned. The findings of several authors have shown that often significant improvements can be achieved in surveillance, transport in general, or traceability of food, and ultimately food waste can be reduced. However, benefits can also be gained using new non-IoT-based technologies. Thus, the main knowledge of this bachelor thesis is that a theoretical 'ideal' transport system contains a sensible combination of technologies with and without IoT. This system includes the use of a Wireless Sensor Network (WSN) for real-time food monitoring, as well as an alarm function when the temperature exceeds a maximum. Real-time monitoring with GPS coupled with a monitoring center to prevent traffic jams is another task. Smart and energy-efficient packaging, and finally the use of the new supercooling-technology, make the system significantly more efficient in reducing food waste. These highlights, that when choosing a transport system, which is as efficient and profitable as possible for food with refrigerated transport, companies need not just rely on the use of IoT. On this basis, it is advisable to combine the systems and technologies used so far with IoT in order to avoid as much food waste as possible.


Celebrating twenty years of an agenda-setting powerhouse of contemporary style, design, and popular culture. Celebrated for discovering and promoting new artists, musicians, designers, and filmmakers, "Dazed & Confused" magazine has been a barometer of popular style and culture since its founding in London in 1991 by Jefferson Hack and the photographer Rankin. Quickly renowned for its controversial attitude, Dazed represented a new wave in the British style press, bringing together figures from different creative fields and eras to produce extraordinary interviews and develop artwork for the magazine. From David Bowie to Bjork, Harmony Korine to David Lynch, Kate Moss to Stockhausen, and Rankin to Thom Yorke, the roster of the magazine's subjects and contributing artists alone is a record of the evolution of contemporary pop culture. Edited by its founders, this daringly illustrated book immortalizes the magazine's most enduring features, from legendary photo shoots and iconic covers to controversial interviews, and supplements them with outtakes, ephemera from the editors' offices, original artwork, and contributions from the photographers, designers, and artists behind it all.


The newly emergent human virus SARS-CoV-2 is resulting in high fatality rates and incapacitated health systems. Preventing further transmission is a priority. We analysed key parameters of epidemic spread to estimate the contribution of different transmission routes and determine requirements for case isolation and contact-tracing needed to stop the epidemic. We conclude that viral spread is too fast to be contained by manual contact tracing, but could be controlled if this process was faster, more efficient and happened at scale. A contact-tracing App which builds a memory of proximity contacts and immediately notifies contacts of positive cases can achieve epidemic control if used by enough people. By targeting recommendations to only those at risk, epidemics could be contained without need for mass quarantines ('lock-downs') that are harmful to society. We discuss the ethical requirements for an intervention of this kind.


The synthesis of pterin-dithiolene ligands was achieved by employing the radical nucleophilic substitution, i.e. the so-called "Minisci- Reaction"1. This protocol was used for the first time by Professor W. Pfleiderer on pterin substrates2 and proved a powerful method for the preparation of 6 acyl-pterins in course of this work. Subsequent construction of the dithiolene ring facilitates the synthesis of pterin-dithiolene ligands with completely unprotected pterin moieti.
The molybdenum cofactor is probably one of the most relevant discoveries in the recent history of pterin chemistry and biochemistry. Many efforts have been made for the preparation of compounds able to mimic the features of the Moco ligand system called "Molybdopterin". In fact, the study of MPT models enables a deeper understanding of the "mechanism of function" of this cofactor and most importantly, lays the foundation for a potential treatment for the Moco related diseases MoCOD and iSOD.


This essay recites the history of the Polley v. Ratcliff litigation and interrogates its relevance for modern considerations of racial inequality in America. The Polley case began in 1850s with the wrongful kidnapping of the children of Mr. Peyton Polley, an emancipated African slave who lived in Ohio. The litigation continued from 1851 to 1859 without clear resolution. Although this incident has been discussed at length by historians, the litigation itself came to a remarkable conclusion on April 6, 2012. On that day, some 162 years after this Dred Scott-era kidnapping, Judge Darrell Pratt of the Circuit Court of Wayne County, West Virginia, entered a decree declaring that Mr. Polley wrongfully kidnapped children — Harrison, Louisa, and Anna — "were, and are, FREE PERSONS as of March 22, 1859." This declaration represented a monumental historical moment in West Virginia history, and it represents, as this essay will argue, an opportunity to consider the question of what our societal response to slavery and racism has been over time and what it ought to be in the twenty-first century. The essay considers the various modes through which Americans look at the history of slavery and race-race consciousness, racial reparations, and post racialism — and then it argues that the Polley litigation represents a different model for considering the American history of race, a model akin to truth and reconcilliation.


"The study of childhood aggression increasingly examines the developmental trajectories of different types of aggression. While a variety of subtyping systems exist for defining aggression, most systems seem to be consistently defining proactive (i.e. bullying, unprovoked aggression) and reactive (i.e. impulsive, in retaliation) subtypes. Keenan and Shaw (2003) have developed a causal theory which attributes infant over or underarousal, paired with caregiving that is insensitive to the needs of the child, as setting the child on either one of the aggressive pathways. The current study tests a piece of Keenan and Shaw's theory by examining child and parent correlates of proactive and reactive aggression in an early childhood sample rated as having high levels of aggression by their parents and teachers. Child variables included emotion regulation and negative emotionality. Parent variables included corporal punishment, inconsistent discipline, punitive parenting, interparental violence, and harsh physical discipline. Other demographic variables were considered, including socioeconomic status, maternal age, and child gender. Results suggest that proactive aggression is not a frequent phenomenon in early childhood, even among aggressive children, and in our study no variables uniquely predicted the subtypes. Significant limitations of the study, as well as clinical implications and future directions for research are discussed."--Abstract from author supplied metadata.


A method has been developed for the determination of gold and the platinum group elements at the low concentrations found in most geological materials, utilising the advantageous properties of Inductively Coupled Plasma-Mass Spectrometry (lCP¬MS) analysis. The method has been applied to assess the distribution of the precious metals in south-west England. Results from this study are combined with previously published data on the distribution of precious metal enrichments and new fluid inclusion data, to determine the origin of these enrichments.
The methodology developed uses a sodium peroxide fusion of a small (1.0 g) sample of powdered geological material, with separation by tellurium co-precipitation and determination by ICP-MS. Isotope dilution calibration is used where possibe to overcome losses through the procedure, but data for monoisotopic elements (Au, Rh) are obtained by external calibration. Detection limits for the method are excellent, being < 0.5 ng g-l for Au, Pt, Pd and the minor PGEs: Ru, Rh and Ir. Good agreement with reference data for certified reference materials WGB-l, TDB-l and UMT-l was obtained. Pd data were reliable throughout the method testing. Data for Pt and Au improved through the method development phase. The minor PGEs gave reliable data for high concentration reference materials. Field sample data were only reliable for Pd, Pt and Au; minor PGE concentrations were too low to allow quantitation. Low concentration Ir results showed a systematic error.Small quantities of gold have previously been found in south-west England.
New data confirm the presence of gold in mineral materials from Hope Nose and LoddisweIl. Most of the area shows low precious metal concentrations, probably due to the lack of potential source rocks. Anomalous precious metal concentrations are found associated with deep-seated cross-course structures. These may have allowed the ingress of precious metal-bearing fluids from deeper crustal levels. A spatial association with greenstone basic volcanics is also seen, but the greenstones analysed do not show anomalously high precious metal concentrations. Palladium shows a greater dispersion than either Au or Pt; small amounts being detected in most areas sampled.


This work has been motivated by two long term goals: to understand how humans learn language and to build programs that can understand language. Using a representation that makes the relevant features explicit is a prerequisite for successful learning and understanding. Therefore, I chose to represent relations between individual words explicitly in my model. Lexical attraction is defined as the likelihood of such relations. I introduce a new class of probabilistic language models named lexical attraction models which can represent long distance relations between words and I formalize this new class of models using information theory.
Within the framework of lexical attraction, I developed an unsupervised language acquisition program that learns to identify linguistic relations in a given sentence. The only explicitly represented linguistic knowledge in the program is lexical attraction. There is no initial grammar or lexicon built in and the only input is raw text. Learning and processing are interdigitated. The processor uses the regularities detected by the learner to impose structure on the input. This structure enables the learner to detect higher level regularities. Using this bootstrapping procedure, the program was trained on 100 million words of Associated Press material and was able to achieve 60% precision and 50% recall in finding relations between content-words. Using knowledge of lexical attraction, the program can identify the correct relations in syntactically ambiguous sentences such as "I saw the Statue of Liberty flying over New York." (Copies available exclusively from MIT Libraries Rm. 14-0551, Cambridge, MA 02139-4307 Ph. 617-253-5668; Fax 617-253-1690.)


Contracts between suppliers and customers frequently contain provisions rewarding the customer for exhibiting loyalty to the seller. For example, suppliers may offer customers preferential pricing for buying a specified percentage of their requirements from the supplier or buying minimum numbers of products across multiple product lines. Such loyalty-inducing contracts have come under attack on antitrust grounds because of their potential to foreclose competitors or soften competition by enabling tacit collusion among suppliers. This article defends loyalty inducement as a commercial practice. Although it can be anticompetitive under some circumstances, rewarding loyal customers is usually procompetitive and price-reducing. The two most severe attacks on loyalty discounting — that loyalty discounts are often disguised disloyalty penalties and that loyalty clauses soften competition — are unlikely to hold as a general matter. Nor are arguments that customers only accede to loyalty inducements because of collective action problems generally true. Dominant buyers who face few collective action problems frequently use loyalty commitments to leverage their buying power and obtain lower prices.


Studies were conducted to evaluate the impact of plastic mulches viz. black, clear andbare soil in the modification of plant growing environments on three hot pepper hybrids namely Sky Red, Maha and Wonder King in poly/plastic tunnels during the year 2005-06 and 2006-07. Hot pepper hybrids and plastic mulches had significant effect on plant growth and yield attributes. By using clear plastic mulch intensive weed proliferation was problematic issue; however under black plastic mulch almost complete weed suppression was achieved which results in increased fruit yield than hot peppers grown under clear plastic mulch and bare soil (control).
The pattern of antioxidant accumulation was envisaged in hot peppers harvested at different stages; immature green, mature green, color break, red ripe and dried fruit. Capsaicinoids had significant distribution in mature green stage while progressive accretion of carotenoids and ascorbic acid was observed at dried and red ripe stage of all hybrids, respectively. However, the pattern of total phenolic contents biosynthesis was found significant at immature green stage in Sky Red where as in Maha at color break stage and in case of Wonder King at red ripe stage.
Aflatoxin contamination in hot pepper hybrids was investigated under various temperatures (20, 25 and 30°C) and packaging regimes (polyethylene and jute bags) during five months storage period. Aflatoxin detection under these conditions had lower levels than the existing regulatory limits ascribed by European Commission (EC No. 1881/2006) that is 10μg kg-1 for total aflatoxins. Aflatoxin contamination and microbial load was increased significantly with the increase in temperature and storage duration which was heavily infested when samples packed in jute bags and stored at 25 and 30°C respectively. Storage duration and temperature regimes had inverse relation on antioxidant quality of hot pepper ecotypes as well.
Further attempts were made to decontaminate aflatoxin contaminated samples of hot pepper hybrids (from previous study) subjected to gamma radiation (2, 4 and 6 kGy) and its effect on antioxidant stability was again assessed after three month storage. Higher the irradiation dose, lower the concentration of carotenoids and ascorbic acid ascertained in hot pepper ecotypes; however, capsaicinoids and polyphenols rendered greater stability at higher irradiation dose during storage. Irradiated samples of hot peppers had 7% xii reduction in aflatoxin contamination as compared to non-irradiated (control). Total fungal population had inverse relation with increasing radiation dose and complete inhibition was observed when irradiated at 6 kGy and no further fungal proliferation was seen during three months storage at ambient conditions.


To understand the rising prevalence of obesity in affluent societies, it is necessary to take into account the growing obesity infrastructure, which over past decades has developed into an obesogenic environment. This infrastructure is a direct reflection of the mainstream economic growth paradigm that the literature on consumer culture characterizes as chronic overconsumption. This study examines the effects of one of the constituent factors of consumer societies and a key contributory factor to childhood obesity: commercial food communication targeted to children and its impact on their food knowledge and food preferences. Because evaluations of traditional informationand education-based interventions suggest that they may not sustainably change food patterns, we combine insights from behavioral economics and traditional consumer behavior theory to formulate seven hypotheses, which we then test using a subsample from the IDEFICS study. The results reveal not only that advertising has divergent effects on children's food knowledge and preferences but that food knowledge is unrelated to food preferences, a finding that has important implications for future research and public policy.


"If a writer of prose knows enough about what he is writing about, he may omit things that he knows, and the reader, (if the writer is writing truly enough) will have a feeling of those things as strongly as though the writer had stated them. The dignity of movement of an iceberg is due to only one-eighth of it being above water. A good writer does not need to reveal every detail of a character or action."


This article takes as its point of departure the financing technique referred to as "securitization," a close cousin of secured lending that has grown to enormous size since its origin more than two decades ago. The article pursues two themes. One is a critique of the legal foundations of securitization, which includes a perspective on aspects of fraudulent transfer law that are well established historically but have been neglected in recent decades. The other is exploration of the implications of this product growing so vast despite its dubious legal foundations. In that regard, the article explores two points of legal sociology that apply to new financial products generally. The first is that a product can become so widely used that it cannot be permitted to fail, notwithstanding its dubious legal foundations. The second is that the debt rating agencies have become de facto lawmakers, because it is their decision to give a favorable rating to a financial product the credit quality of which depends on a debatable legal judgment that allows the product to grow too big to fail. Two nascent products are identified as candidates for the operation of a similar dynamic. The article ends with a normative assessment of securitization from a pragmatic perspective, concluding that legislative action is appropriate to ratify the product's object, with constraints.


Two of the most visible and important trends in higher education today are its exploding costs and the rapid expansion of online learning. Could the growth in online courses slow the rising cost of college and help solve the crisis of affordability? In this short and incisive book, William G. Bowen, one of the foremost experts on the intersection of education and economics, explains why, despite his earlier skepticism, he now believes technology has the potential to help rein in costs without negatively affecting student learning. As a former president of Princeton University, an economist, and author of many books on education, including the acclaimed bestseller The Shape of the River, Bowen speaks with unique expertise on the subject. Surveying the dizzying array of new technology-based teaching and learning initiatives, including the highly publicized emergence of "massive open online courses" (MOOCs), Bowen argues that such technologies could transform traditional higher education--allowing it at last to curb rising costs by increasing productivity, while preserving quality and protecting core values. But the challenges, which are organizational and philosophical as much as technological, are daunting. They include providing hard evidence of whether online education is cost-effective in various settings, rethinking the governance and decision-making structures of higher education, and developing customizable technological platforms. Yet, Bowen remains optimistic that the potential payoff is great. Based on the 2012 Tanner Lectures on Human Values, delivered at Stanford University, the book includes responses from Stanford president John Hennessy, Harvard University psychologist Howard Gardner, Columbia University literature professor Andrew Delbanco, and Coursera cofounder Daphne Koller.


Chronic pain is thought to arise because of maladaptive changes occurring within the peripheral nervous system and CNS. The transition from acute to chronic pain is known to involve the spinal cord (Woolf and Salter, 2000). Therefore, to investigate altered human spinal cord function and translate results obtained from other species, a noninvasive neuroimaging technique is desirable. We have investigated the functional response in the cervical spinal cord of 18 healthy human subjects (aged 22–40 years) to noxious thermal and non-noxious tactile stimulation of the left and right forearms. Physiological noise, which is a significant source of signal variability in the spinal cord, was accounted for in the general linear model. Group analysis, performed using a mixed-effects model, revealed distinct regions of activity that were dependent on both the side and the type of stimulation. In particular, thermal stimulation on the medial aspect of the wrist produced activity within the C6/C5 segment ipsilateral to the side of stimulation. Similar to data recorded in animals (Fitzgerald, 1982), painful thermal stimuli produced increased ipsilateral and decreased contralateral blood flow, which may reflect, respectively, excitatory and inhibitory processes. Nonpainful punctate stimulation of the thenar eminence provoked more diffuse activity but was still ipsilateral to the side of stimulation. These results present the first noninvasive evidence for a lateralized response to noxious and non-noxious stimuli in the human spinal cord. The development of these techniques opens the path to understanding, at a subject-specific level, central sensitization processes that contribute to chronic pain states.


"Pulling Newspapers Apart: Analysing Print Journalism" explores contemporary UK national and local newspapers at a significant and pivotal moment in their development when some pundits are busily, if mistakenly, announcing their demise.The book offers a detailed examination of features which previous studies have tended to neglect, such as editorial formats (News, Op Ed pages, readers' letters, cartoons, obituaries, advice columns, features and opinion columns), aspects of newspaper design (page layout, photographs, supplements, online editions, headlines, the emergence of the compact and Berliner editions), newspaper contents (sport, sex and Page 3, royalty, crime, moral panics and politics) as well as the content of newspapers which is not generated by in house journalists (advertising, TV listings, horoscopes, agency copy and public relations materials). This innovative and accessibly written collection provides journalism and media students with an invaluable study of newspapers in the digital age.


The John Joseph Murphy Collection contains diaries, correspondence, reports and photographs, relating to Murphy's service in the Australian administration of Papua New Guinea in a number of official positions between 1936 and 1969. Includes material relating to John J. Murphy's book, The book of Pidgin English; also a small amount of family history papers relating to the Campbell, Boyd, and Pratt families, including letters from Austin Pratt written after his evacuation from Gallipoli.


The study of human body measurements on a comparative basis is known as anthropometrics. Its applicability to the design process is seen in the physical fit, or interface, between the human body and the various components of interior space. "Human Dimension and Interior Space" is the first major anthropometrically based reference book of design standards for use by all those involved with the physical planning and detailing of interiors, including interior designers, architects, furniture designers, builders, industrial designers, and students of design. The use of anthropometric data, although no substitute for good design or sound professional judgment should be viewed as one of the many tools required in the design process. This comprehensive overview of anthropometrics consists of three parts. The first part deals with the theory and application of anthropometrics and includes a special section dealing with physically disabled and elderly people. It provides the designer with the fundamentals of anthropometrics and a basic understanding of how interior design standards are established. The second part contains easy-to-read, illustrated anthropometric tables, which provide the most current data available on human body size, organized by age and percentile groupings. Also included is data relative to the range of joint motion and body sizes of children. The third part contains hundreds of dimensioned drawings, illustrating in plan and section the proper anthropometrically based relationship between user and space. The types of spaces range from residential and commercial to recreational and institutional, and all dimensions include metric conversions. In the Epilogue, the authors challenge the interior design profession, the building industry, and the furniture manufacturer to seriously explore the problem of adjustability in design. They expose the fallacy of designing to accommodate the so-called average man, who, in fact, does not exist. Using government data, including studies prepared by Dr. Howard Stoudt, Dr. Albert Damon, and Dr. Ross McFarland, formerly of the Harvard School of Public Health, and Jean Roberts of the U.S. Public Health Service, Panero and Zelnik have devised a system of interior design reference standards, easily understood through a series of charts and situation drawings. With "Human Dimension and Interior Space," these standards are now accessible to all designers of interior environments.


Intimidated by her father, the rector of Knype Hill, Dorothy performs her submissive roles of dutiful daughter and bullied housekeeper. Her thoughts are taken up with the costumes she is making for the church school play, by the hopelessness of preaching to the poor and by debts she cannot pay in 1930s Depression England. Suddenly her routine shatters and Dorothy finds herself down and out in London. She is wearing silk stockings, has money in her pocket and cannot remember her name. Orwell leads us through a landscape of unemployment, poverty and hunger, where Dorothy's faith is challenged by a social reality that changes her life.


Measurements of formaldehyde (CH2O) from a tunable diode laser absorption spectrometer (TDLAS) were acquired onboard the NASA DC-8 aircraft during the summer 2004 INTEX-NA campaign to test our understanding of convection and CH2O production mechanisms in the upper troposphere (UT, 6–12 km) over continental North America and the North Atlantic Ocean. The present study utilizes these TDLAS measurements and results from a box model to (1) establish sets of conditions by which to distinguish "background" UT CH2O levels from those perturbed by convection and other causes; (2) quantify the CH2O precursor budgets for both air mass types; (3) quantify the fraction of time that the UT CH2O measurements over North America and North Atlantic are perturbed during the summer of 2004; (4) provide estimates for the fraction of time that such perturbed CH2O levels are caused by direct convection of boundary layer CH2O and/or convection of CH2O precursors; (5) assess the ability of box models to reproduce the CH2O measurements; and (6) examine CH2O and HO2 relationships in the presence of enhanced NO. Multiple tracers were used to arrive at a set of UT CH2O background and perturbed air mass periods, and 46% of the TDLAS measurements fell within the latter category. In general, production of CH2O from CH4 was found to be the dominant source term, even in perturbed air masses. This was followed by production from methyl hydroperoxide, methanol, PAN-type compounds, and ketones, in descending order of their contribution. At least 70% to 73% of the elevated UT observations were caused by enhanced production from CH2O precursors rather than direct transport of CH2O from the boundary layer. In the presence of elevated NO, there was a definite trend in the CH2O measurement–model discrepancy, and this was highly correlated with HO2 measurement–model discrepancies in the UT.


Athletes can be at elevated risk for developing eating disorders, the effects of which can be devastating. Few researchers have examined the influence of a predisposition toward an eating disorder on athletic injury. Exercise dependence might bridge the gap toward understanding this relationship. This study sought to examine the relationship between predisposition toward an eating disorder and exercise dependence and looked at both as predictors of athletic injury. College students (n = 132) completed the Eating Disorders Inventory and the Exercise Dependence Questionnaire, as well as provided demographic, activity, and injury information. Subscales of the Eating Disorders Inventory and Exercise Dependence Questionnaire were significant predictors of having at least one athletic injury in the preceding year. These findings suggest that both predisposition toward an eating disorder and exercise dependence may be contributing factors to injury.


Functional composition, the application of one function to the results of another function, has a long history in the mathematics community, particularly in the context of polynomials and rational functions. This thesis articulates and explores a general framework for the use of functional composition in the context of signal processing. Its many potential applications to signal processing include utilization of the composition of simpler or lower order subfunctions to exactly or approximately represent a given function or data sequence. Although functional composition currently appears implicitly in a number of established signal processing algorithms, it is shown how the more general context developed and exploited in this thesis leads to significantly improved results for several important classes of functions that are ubiquitous in signal processing such as polynomials, frequency responses and discrete multivariate functions. Specifically, the functional composition framework is exploited in analyzing, designing and extending modular filters, separating marginalization computations into more manageable subcomputations and representing discrete sequences with fewer degrees of freedom than their length and region of support with implications for sparsity and efficiency. Thesis Supervisor: Alan V. Oppenheim Title: Ford Professor of Engineering


Investors and managers evaluate potential investments in terms of risk and return. Research has focused on linking marketing activities and resource deployments with returns but has largely neglected marketing's role in determining risk. Yet the theoretical literature asserts that investments in market-based assets, such as brands, should lead to reductions in firm risk. Adopting risk measures that are well established in the finance literature, the authors use credit ratings to capture debt-holder risk and the standard deviation of stock returns to measure equity-holder risk, which they then decompose into systematic and unsystematic equity risk. The authors examine the impact of consumer-based brand equity (CBBE) on firm risk using data covering 252 firms from EquiTrend, COMPUSTAT, and the Center for Research in Security Prices over the 2000–2006 period. They find that a firm's CBBE is associated with firm risk and explains variance in the risk measures beyond that explained by existing finance models (i.e., it has "risk relevance"). They also find that CBBE has a stronger role in predicting firm-specific unsystematic risk than systematic risk but that it also has a particularly strong role in protecting equity holders from downside systematic risk. The results have clear economic significance and suggest that managers should make brand management part of the firm's risk management strategy and protect or even increase CBBE investments during periods of economic uncertainty.


In the Fastolf Papers in the Archives of Magdalen College, University of Oxford, is an account of payments and expenses of Sir John Fastolf made during ten years of litigation from 1449-1459, Fastolf Paper 42. One entry in this document is both puzzling and interesting. It reads: Item paid by Thomas Howes . . . for the fee of shackles called the sewet (feodo de compedibus vocato le sewet) both for himself and for John Porter until the jurors impaneled in the attaint might appear before the justices of the King at Westminster In this instance, the payment occurred in connection with an attaint brought by John Porter, a Fastolf servant, to overturn a jury verdict in a conspiracy case brought against him and another Fastolf servant, Thomas Howes by John Andrew, a Suffolk official and lawyer and a member of the East Anglian affinity of William de la Pole, the Duke of Suffolk. This entry raises several interesting questions: what was the fee of shackles and why was it called the 'sewet'? The answer lies in the financial characteristics of the medieval century prison system, its 'Oeconomy.' Moreover, understanding the meaning of sewet does not answer the substantive question regarding the propriety of its imposition. The purpose of this paper is to explore these questions. In general, sewet was a payment of money or practice to make prison life less onerous. The paper begins with an overview of the various fees charged prisoners by keepers in the medieval prisons, especially those in London, the Fleet, Newgate, Ludgate, the King's Bench Marshalsea and the sheriff's Counters. The charging of fees by keepers was a controversial practice. There were persistent complaints about these fees. From the 14th century through the 17th century, there were numerous regulations enacted detailing what fees were permissible and the amounts that could be charged. The paper turns to use of irons, a controversial practice, both to determine what were considered the appropriate and inappropriate uses of irons and to understand the legitimacy of the fee for removing them, feodo de compedibus. A primary justification for the use of irons was to prevent prisoners from escaping. However, prisoners complained about the inappropriate use of irons and the imposition of fees to remove them. Again, over several centuries, numerous measures regulated such fees. With this background, the paper then focuses on the meaning of sewet, a later spelling of suete, which was part of a term, suete de prisone. This term perplexed medieval scholars at the beginning of the 20th century. Although they correctly identified the core meaning, the primary investigation failed to understand that the various contexts in which it was used suggested that there were multiple meanings of the term. There was also contemporary confusion as to what Latin word was appropriate to use in official records. By the middle of the 20th century, Latham connected this Law French term with the Latin word, suavitas. Thus, sewet meant a payment of money for ameliorating prison conditions, making life there 'sweeter.' Although not disagreeing with this earlier scholarship, the paper argues for further refinement of the meaning, connecting the term also with the liability of keepers for the escape of prisoners. The paper reviews the multiple contexts and spellings of sewet and its equivalents to further explore its meaning and use. The paper asserts that the most common reason for paying sewet or suete de prisone was the removal the prisoner's irons. Removal of the irons increased the likelihood of escape and the potential for the keeper's liability for a fine or damages because of the escape as well liability for the debt of prisoner to the latter's creditor. The paper then turns to an analysis of the propriety of charging sewet in the particular instance reflected in the entry in the Fastolf Paper 42. The use of irons was permissible in some instance and escape from the King's Bench Marshalsea was a recognized problem. However the use of irons was probably inappropriate in the case of Howes and Porter, given the reason for their imprisonment, their failure to pay a ransom to the king for their conviction in Andrew's conspiracy suit, and the low likelihood of their escape. While it is impossible to know the amount of the fee in this case, it may not be necessary as a 1445 statute appeared to prohibit the charging of sewet. Moreover, plea roll entries suggest that during the time of Howes and Porter were charged sewet, the statute was enforced strictly. In addition, Sir John Fastolf, who paid all these expenses, was a visible and easy target, for an abusive charge. Thus the paper concludes that charging of sewet to remove Howes' and Porter's irons was dubious and probably, although not clearly, inappropriate.


Halogenated flame retardants (HFRs) have been applied since the 1960s in various industrial and consumer products to protect humans as well as private and public possessions. In the past decade polybrominated diphenyl ethers (PBDEs), formerly the major applied HFRs were widely restricted and adopted as Persistent Organic Pollutants (POPs) in the Stockholm Convention due to their adverse effects on humans and the environment as well as their ubiquitous occurrence in the global environment. Besides PBDEs, various alternative HFRs have been applied for decades as well, or were recently developed to replace PBDEs. However, their potential adverse properties, environmental distribution and fate are largely unknown. Therefore, this thesis addresses the global occurrence, distribution and transport of alternative HFRs versus PBDEs in the marine atmosphere and seawater toward the Polar Regions in order to examine their longrange atmospheric transport (LRAT) potential. This thesis presents the first data on alternative HFRs in the atmosphere of the marine environment and the Polar Regions.
Alternative brominated flame retardants (BFRs), Dechlorane compounds and PBDEs were investigated in high-volume air and seawater samples taken along several sampling transects in the Atlantic Ocean, Pacific Ocean and Indian Ocean toward the Polar Regions of the Arctic and Antarctic. In addition, three sampling cruises were conducted in the German Bight, North Sea. Several alternative HFRs were detected in the global marine atmosphere and seawater with hexabromobenzene (HBB), pentabromotoluene (PBT), pentabromobenzene (PBBz), 2,3- dibromopropyl-2,4,6-tribromophenyl ether (DPTE) and Dechlorane Plus (DP) being the predominant compounds which were observed in concentrations similar or even higher than PBDEs. Total atmospheric concentrations ranged from <1 pg m-3 over the open oceans up to 42 pg m-3 over the East Indian Archipelago. Seawater concentrations ranged from <1 pg L-1 in open ocean seawater up to 21 pg L-1 in coastal regions, while estuarine concentrations reached up to 6800 pg L-1. Overall, the comparison revealed that alternative HFRs dominate versus PBDEs in air and seawater, both in coastal regions as well as the Polar Regions, showing a shift from PBDEs toward alternative HFR in the marine atmosphere and seawater.
The distribution in the global atmosphere was strongly influenced by the proximity to potential source regions and the pathway of the sampled air masses. Highest concentrations were observed in continentally influenced air masses, while low background concentrations occurred during sampling of oceanic remote air masses. In general, Western Europe, East and Southeast Asia but also Africa were identified as source regions for the marine environment, especially for alternative HFRs as well as BDE-209. In contrast, relatively low peak concentrations of the PBDE congeners of the Penta- and OctaBDE mixtures under continental influence were observed, indicating limited emissions of legacy PBDEs.
The dry air-seawater gas exchange estimation showed that the atmosphere is a source for seawater resulting in net deposition into the global oceans after atmospheric emissions and transport, both in coastal regions as well as in the open oceans. Besides atmospheric depositions, riverine discharge was shown to act as source for coastal environments.
The investigation of sampling transects toward the Polar Regions revealed that several alternative HFRs – in particular HBB, PBT, DPTE, PBBz and DP – undergo LRAT toward the Polar Regions in an extent similar to PBDEs and, therefore, meet the LRAT criterion of POPs under the Stockholm Convention. DP was found to undergo LRAT attached to airborne particles whereby stereoselective LRAT differences were shown for the two DP stereoisomers. With respect to LRAT, the results of this thesis therefore imply that alternative HFRs – in particular HBB, PBT, DPTE and DP – aren't suitable replacements for PBDEs, but chemicals of emerging global environmental concern and possible future POPs.


In this article, the authors discuss what students are doing to reconcile the differences between institutional ethical review standards and the reality of community-based, qualitative research, particularly in northern Canada. They examine the experiences of 12 students who are currently undertaking or have recently completed qualitative research in the North. Students raised concerns about what informed consent really mean; the contentiousness of obtaining written consent, and modified consent forms and the flexibility of research ethics board (REB) standards. The authors demonstrate that significant judgment is required in the introduction of ethics procedures in northern Canadian research. More work is needed to guide novice researchers and help build their agency for making ethical judgments in the field.