The world after the COVID-19 pandemic

Philosophy

In the case of the COVID-19 pandemic, there are some signs of a shift of paradigm, including the sudden disappearance of the wall ideology: a cough was enough to suddenly make it impossible to avoid the responsibility that each individual has towards all living beings for the simple fact that it is part of this world, and of the desire to be part of it. The whole is always involved in part, because everything is, in a sense, in everything and in nature there are no autonomous regions that are an exception.
          The virus seems to restore the supremacy that once belonged to politics. One of the virtues of the virus is its ability to generate a more sober idea of freedom: to be free means to do what needs to be done in a specific situation.
          DOI: 10.13140/RG.2.2.20745.67681

The world after the COVID-19 pandemic Nicolae Sfetcu 07.11.2020 Sfetcu, Nicolae, "The world after the COVID-19 pandemic", SetThings (November 7, 2020), DOI: 10.13140/RG.2.2.20745.67681, URL = https://www.telework.ro/en/the-world-after-thecovid-19-pandemic/ Email: firstname.lastname@example.com This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International. To view a copy of this license, visit http://creativecommons.org/licenses/by-nd/4.0/. Translation of: Sfetcu, Nicolae, "Lumea după pandemia COVID-19", SetThings (14 octombrie 2020), DOI: 10.13140/RG.2.2.29865.83041, URL = https://www.telework.ro/ro/lumea-dupa-pandemia-covid19/ Nicolae Sfetcu: The world after the COVID-19 pandemic 2 Abstract In the case of the COVID-19 pandemic, there are some signs of a shift of paradigm, including the sudden disappearance of the wall ideology: a cough was enough to suddenly make it impossible to avoid the responsibility that each individual has towards all living beings for the simple fact that it is part of this world, and of the desire to be part of it. The whole is always involved in part, because everything is, in a sense, in everything and in nature there are no autonomous regions that are an exception. The virus seems to restore the supremacy that once belonged to politics. One of the virtues of the virus is its ability to generate a more sober idea of freedom: to be free means to do what needs to be done in a specific situation. Nicolae Sfetcu: The world after the COVID-19 pandemic 3 The world after the COVID-19 pandemic In the case of the COVID-19 pandemic, there are some signs of a shift of paradigm, including the sudden disappearance of the "wall" ideology: "a cough was enough to make it suddenly impossible to evade the responsibility that each individual has towards all living beings for the simple fact of (still...) being part of this world, and of wanting to be part of it". (Foucault, Agamben, and Benvenuto 2020) The whole is always involved in part, that "everything is, in certain sense, in everything" and that in nature there are no autonomous regions that are an exception. In nature there is no " dominion within another", according to Spinoza. (Spinoza 2019) The epidemic leads to the creation of red zones, internal isolation and the militarization of territories, but here "the wall has a completely different meaning compared to the walls the rich build to keep out the poor. A wall is being erected for the other, whoever she or he may be". (M. Foucault, Agamben, and Benvenuto 2020) Ronchi believes that these walls are erected to replace handshakes, they are a means of communication, not a sign of exclusion. The COVID-19 pandemic necessitates the application of pragmatic intelligence to govern, as far as possible, the spontaneity of a process that takes place against our intentions. The political command will have to assume specific responsibility. it will have to take precedence over the economy. In addition, the virus invites us to meditate on our fragility. He has the ability to generate a more sober idea of freedom: to be free means to do what needs to be done in a specific situation. The famous French philosopher Bruno Latour wrote an essay for the AOC newspaper, Imaginer les gestes-barrières contre le retour à la production d'avant-crise, stating that this lesson is "the most amazing: we have actually shown that it is possible, in a few weeks, to stop all economic systems in the world..." (Latour 2020) Nicolae Sfetcu: The world after the COVID-19 pandemic 4 Bruno Latour considers this epidemic to be a huge opportunity for us to learn; a huge experiment. Viruses are in us, and we will have to learn to live with them. Epidemic isolation has forced us all to retreat into ourselves through introspection. The questions we asked ourselves developed a different way of thinking about how they would create a different future than the one we had foreseen. The pandemic has shown us how quickly we can become infected globally. An incredible demonstration of network theory and the power of virality. This implies a fusion, in a sense, between the individual and the collective. The pandemic has reopened the debate about what is necessary and what is possible, what is useful and what is not. We will not have to change the production system, but to replace it completely. Bruno Latour states that if he had enough power, he would first and foremost change the production system on an ecological basis. At the ZKM Center for Art and Media in Karlsruhe, Germany, (Arènes 2020) the sphere of human existence was defined as the "critical zone", a narrow band of Earth that can support life, including only a few kilometers thick above and below the Earth's surface. In light of this concept, you can be an escapee trying to escape from this area, like Elon Musk, or a captive. but for us captives, resources are limited. We have to take care of what we have, because it's finished. This seems to add a political limit to James Lovelock's Gaia hypothesis (J. Lovelock 2001) which explains how "Life" acts to protect itself. Compared to the infinity of worlds preached by science, Lovelock, together with Margulis, (J. E. Lovelock and Margulis 1974) proved that the Earth is unique because it has life. Bruno Latour considers the confirmation of the idea of the two as his greatest discovery of this period, although not yet accepted by mainstream science. In this Nicolae Sfetcu: The world after the COVID-19 pandemic 5 sense, the shift of paradigm from Aristotelian cosmology to Galileo is just as important as from Galileo to Gaia. (Sfetcu 2020) Buheji and Ahmed highlight the opportunities and possible positive effects generated by the COVID-19 pandemic (Buheji, Ahmed, and Ahmed 2020) and the relationship between the crisis and the global societies of extreme capitalism. They summarized the respective ideas in two tables: Visible and hidden socio-economic opportunities of the crisis (COVID-19) Opportunities: (Buheji, Ahmed, and Ahmed 2020) Visible Opportunities Hidden Opportunities Beyond Technology Advancement Controlling & Balancing the Growth Model Rise of Safety-Entrepreneurship Controlling Diverting Socio-economic Development Understanding the Fragility of Capital Economy Controlling Resilience Attentions Understanding the Importance of World Harmony Getting to Work Out of Comfort-Zone Communication Model Enhancing Sharing Economy Importance of Self-Sufficiency New Insights of livelihood and Welfare Promotion Synergy and Community Solidarity Eliminating the Threats of AI Domination Intrinsic Power Enhancing Community Capacity Importance of Credibility and Transparency Living with Minimalist Mindset Value of Physical Contact Enhancing Curiosity Economy The Rise of Epidemiology Re-establishing Our Spiritual & Social-Being Visible and hidden socio-economic opportunities of the crisis (COVID-19) Risks: (Buheji, Ahmed, and Ahmed 2020) Visible Risks Hidden Risks Rise of Cross-infections Limitation of Human Development Capacity Risk Inside & Outside Health Center Being busy with AI while Pathogens are getting sophisticated Limitation of Isolation facilities Stagnant Business Models Increase of Interconnectivity that Spread the Viruses High-rise Building in Global Cities with Minimal Preparedness Uncontrolled Human Apatite & Desire Non-availability of Global Agreed Risk Management Framework Free Market Hostility Low Competence in Solving Socio-economic Complex Problems Nicolae Sfetcu: The world after the COVID-19 pandemic 6 Foodborne-Diseases Chaos Due to Global Panic The authors conclude that the next 20-30 years would be the age of change towards greater dependence on intrinsic powers. In addition, due to the challenge of cross-infections, a new trend could be triggered that affects all types of lifestyle industry. Humanity needs most today not extrinsic powers, but rather intrinsic powers that come from within, but the current mentality driven by the capital economy is not yet ready to accept this choice, being dominated by the lack of need to own and control. (Buheji, Ahmed, and Ahmed 2020) To address climate change and economic inequality, a set of social and economic reforms (Green New Deal GND) (Whyte 2019) has been proposed in the United States that combines Roosevelt's economic approach with modern ideas such as renewable energy. and resource efficiency. (Lovell 2008) There are proposals to include the Green New Deal or parts of it in the US COVID-19 pandemic recovery program (Gilliland 2020) and in the European Union, in April 2020, the European Parliament called for the inclusion of the European Green Agreement in the COVID-19 pandemic recovery program. (European Parliament 2020) The COVID-19 pandemic represents a global paradigm shift, with a strong impact on the global economy and sustainable development scenarios. According to Contipelli, the pandemic highlighted the weakness of current governments, poverty, fragile health and education systems and the lack of international cooperation. (Contipelli and Picciau 2020) Possible future crises cannot be solved with the same economic and social models. Deforestation, biodiversity loss and climate change maximize the likelihood of other pandemics occurring in the future. Contipelli believes that more needs to be invested in renewable energy and sustainable infrastructure and funding new research and development, reforestation, coral reef restoration, regenerative agriculture, sustainable fishing, etc. A sustainable post-pandemic future will exist only through Nicolae Sfetcu: The world after the COVID-19 pandemic 7 international agreements to reduce emissions and increase finance for sustainable development. (Bastian, Jetten, and Chen 2013) Manoj Kr. Bhusal, in The World After COVID-19: An Opportunity For a New Beginning, argues that the world after COVID-19 will be "different and difficult one, with unprecedented economic hardships and rampant social anxieties" (Bhusal 2020) We now have a chance to reflect and review our system, and to come up with a fairer alternative. COVID-19 will shape our economic and political future and leave a profound cultural and psychological impact. COVID-19 will shake global power structures in a disordered and multipolar post-pandemic world. China has proven its effectiveness (Waterson and Kuo 2020) given that, according to Ikenberry, the liberal hegemonic order led by the Americans has already been threatened during the George W. Bush administration. (Ikenberry 2012) Bhusal predicts that the two countries will isolate themselves to serve their own interests, and trade wars and the race for supremacy will intensify. As China is not yet fit and ready to lead the world, with a divided European Union, and more emerging but powerless powers, we will witness a new international order that is not very orderly. The idea of a multipolar world is an older one, being considered by some to be more stable. (Amin 2006) Haass proposes the idea of non-polarity, without a center (nation states, corporations and non-governmental organizations) controlling or dominating any other center. (Haass 2020, 44–56) It is possible to develop an increase in repressive regimes and powerful people in some countries, with dictators taking advantage of this pandemic to concentrate power, with Bhusal citing Viktor Orban in Hungary as the first EU dictator. (Kelly 2020) Nicolae Sfetcu: The world after the COVID-19 pandemic 8 Modern technologies already allow almost total pandemic-motivated surveillance, such as smartphones in China, (Xu Elegant and Chandler 2020) facial recognition in Russia, (Ball 2020) police robots in Tunisia, (Jawad 2020) drones in India (Poovanna 2020) or smart bracelets in South Korea. (Cole 2020) These practices will continue after the pandemic, extending abusively to spying on political opponents or suppressing dissent. Thus, the pandemic will fundamentally change the way information services operate. In this regard, Yuval Noah Harari recently wrote: "As a thought experiment, consider a hypothetical government that demands that every citizen wears a biometric bracelet that monitors body temperature and heart-rate 24 hours a day. The resulting data is hoarded and analyzed by government algorithms. The algorithms will know that you are sick even before you know it, and they will also know where you have been, and who you have met." (Harari 2020) Bhusal notes that, although instability, global conflicts (United Nations 2020) and poverty will increase, (Picheta 2020) we will not witness the end of globalization. Capitalism and globalization will survive, but multilateralism and global cooperation will fail miserably, reducing international development cooperation activities. The practices adopted during the "quarantine" period (telework, online school and telemedicine) will be normal activities. The digital world and automation in the production and services sector will develop exponentially, redefining consumer behavior. Bhusal concludes that "Most of the problems that we have witnessed during this pandemic, however, are not caused by COVID-19 itself, but by dysfunctional political and social systems built on the foundation of neoliberal corporate capitalism. In that sense, COVID-19 is a wake-up call for a historical retrospection. Hence, the ultimate task of humankind, in the aftermath of this crisis, is to reject patchwork on neoliberal corporate capitalism and construct an alternative system that will be just, inclusive and fair for the many." (Bhusal 2020) Noam Chomsky emphasizes social issues and questions the contradictions of the Western political system and the varying degrees of importance given to each crisis, depending on who suffers from it. (Chomsky, Pollin, and Polychroniou 2020) (Redacción MAPFRE 2020) He Nicolae Sfetcu: The world after the COVID-19 pandemic 9 emphasizes the socio-economic problems that, in his opinion, are products of neoliberalism, and our lack of foresight when it comes to protecting us against a pandemic. But he believes that we have a chance for society to reorganize into a better society. Chomsky insists on the implementation of the Green New Deal, a pact to reduce social inequalities and combat climate change. Chomsky says that "there is no profit in prevention", and that is why we did not invest in it. The concept of "black swan" developed in 2007 by Nassim Nicholas Taleb, (Taleb 2007) which refers to totally unpredictable events, should have been taken into account. According to Rocco Ronchi, in Le virtù del virus, if the virus has the characteristic of an event, it must also possess its "virtue" (a force, a property, a vision, that is, they do something). An event is always traumatic, producing transformations and generating "real" possibilities. The "virtue" of an event thus consists in making possible operational methods, methods that "before" were simply impossible, unimaginable. (Ronchi 2020) In this sense, the "COVID-19 event" shows signs of paradigm shift, the most obvious being the sudden disappearance of the ideology related to "walls". It teaches us that in nature there are no autonomous regions that are an exception. The epidemic leads to zonal isolations, but here the wall has a different meaning than the one that separates the rich from the poor. Here, "your neighbor" is radically reduced to the size of "anyone." The virus seems to restore the supremacy that once belonged to politics. According to a metaphor by Ronchi, the very hypothesis of domination is ridiculed by a cough in Wuhan. In this sense, "COVID-19 also possesses this virtue: it commands politics to assume its specific responsibility, it restores the primacy that politics has illusively left to other sovereign spheres, becoming subordinate to them, declaring its own impotence and limiting to play an exclusively technical role". (Ronchi 2020) Nicolae Sfetcu: The world after the COVID-19 pandemic 10 Among the virtues of the virus, we can mention its ability to generate a more sober idea of freedom: to be free means to do what needs to be done in a specific situation. Nicolae Sfetcu: The world after the COVID-19 pandemic 11 Bibliography Amin, S. 2006. "Beyond US Hegemony?: Assessing the Prospects for a Multipolar World." Undefined. 2006. /paper/Beyond-US-Hegemony%3A-Assessing-the-Prospects-for-aAmin/13c6d4ac1b765b70c05b12b7fedf573666b677da. Arènes, Alexandra. 2020. 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"COVID-19: MEPs Call for Massive Recovery Package and Coronavirus Solidarity Fund." April 17, 2020. https://www.europarl.europa.eu/news/en/press-room/20200415IPR77109/covid-19-mepscall-for-massive-recovery-package-and-coronavirus-solidarity-fund. Foucault, M., G. Agamben, and S. Benvenuto. 2020. "Coronavirus and Philosophers | European Journal of Psychoanalysis." 2020. https://www.journal-psychoanalysis.eu/coronavirusand-philosophers/. Gilliland, Donald. 2020. "Coronavirus Calls for an Aggressive Green New Deal." Text. TheHill. March 19, 2020. https://thehill.com/opinion/energy-environment/488356-coronaviruscalls-for-an-aggressive-green-new-deal. Haass, Richard. 2020. "The Age of Nonpolarity," September 2, 2020. https://www.foreignaffairs.com/articles/united-states/2008-05-03/age-nonpolarity. Harari, Yuval Noah. 2020. "Yuval Noah Harari: The World after Coronavirus | Free to Read." March 20, 2020. https://www.ft.com/content/19d90308-6858-11ea-a3c9-1fe6fedcca75. Nicolae Sfetcu: The world after the COVID-19 pandemic 12 Ikenberry, G. John. 2012. Liberal Leviathan: The Origins, Crisis, and Transformation of the American World Order. Reprint Edition. Princeton, NJ Oxford: Princeton University Press. Jawad, Rana. 2020. "Coronavirus: Tunisia Deploys Police Robot on Lockdown Patrol." BBC News, April 3, 2020, sec. Africa. https://www.bbc.com/news/world-africa-52148639. Kelly, Ben. 2020. "If the EU Cannot Rein in Hungary's Dictator Viktor Orban, It Will Rot from the Inside." The Telegraph, March 31, 2020. https://www.telegraph.co.uk/politics/2020/03/31/eu-cannot-rein-hungarys-dictator-viktororban-will-rot-inside/. Latour, Bruno. 2020. "Imaginer les gestes-barrières contre le retour à la production d'avant-crise." AOC media Analyse Opinion Critique (blog). March 29, 2020. https://aoc.media/opinion/2020/03/29/imaginer-les-gestes-barrieres-contre-le-retour-a-laproduction-davant-crise/. Lovell, Jeremy. 2008. "Climate Report Calls for Green 'New Deal.'" 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Ronchi, Rocco. 2020. "Le virtù del virus." Text. Doppiozero. Doppiozero. March 8, 2020. https://www.doppiozero.com/materiali/le-virtu-del-virus. Sfetcu, Nicolae. 2020. "Bruno Latour despre epidemia COVID." SetThings. June 13, 2020. https://www.setthings.com/ro/bruno-latour-despre-epidemia-covid/. Spinoza, Baruch. 2019. Delphi Collected Works of Baruch Spinoza (Illustrated). Delphi Classics. Taleb, Nassim Nicholas. 2007. The Black Swan: The Impact of the Highly Improbable. Random House Publishing Group. United Nations. 2020. "UN Launches COVID-19 Plan That Could 'Defeat the Virus and Build a Better World.'" UN News. March 31, 2020. https://news.un.org/en/story/2020/03/1060702. Waterson, J., and L. Kuo. 2020. "China Steps up Western Media Campaign over Coronavirus Crisis." The Guardian. April 3, 2020. http://www.theguardian.com/world/2020/apr/03/china-steps-up-western-mediacampaign-over-coronavirus-crisis. Whyte, Chelsea. 2019. 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Philosophy

Understanding the mechanics of consciousness remains one of the most important challenges in modern cognitive science. One key step toward understanding consciousness is to associate unconscious physiological processes with subjective experiences of sensory, motor, and emotional contents. This article explores the role of various cellular membrane potential differences and how they give rise to the dynamic infrastructure of conscious experience. This article explains that consciousness is a body-wide, biological process not limited to individual organs because the mind and body are unified as one entity; therefore, no single location of consciousness can be pinpointed. Consciousness exists throughout the entire body, and unified consciousness is experienced and maintained through dynamic repolarization during inhalation and expiration. Extant knowledge is reviewed to provide insight into how differences in cellular membrane potential play a vital role in the triggering of neural and non-neural oscillations. The role of dynamic cellular membrane
          potentials in the activity of the central nervous system, peripheral nervous system, cardiorespiratory system, and various other tissues (such as muscles and sensory organs) in the physiology of consciousness is also explored. Inspiration and expiration are accompanied by oscillating membrane potentials throughout all cells and play a vital role in subconscious human perception of feelings and states of mind. In addition, the role of the brainstem, hypothalamus, and complete nervous system (central, peripheral, and autonomic)within the mind-body space combine to allow consciousness to emerge and to come alive. This concept departs from the notion that the brain is the only organ that gives rise to consciousness.

World Journal of Neuroscience, 2017, 7, 66-81 http://www.scirp.org/journal/wjns ISSN Online: 2162-2019 ISSN Print: 2162-2000 DOI: 10.4236/wjns.2017.71007 January 25, 2017 The Dynamic Role of Breathing and Cellular Membrane Potentials in the Experience of Consciousness Ravinder Jerath1*, Shannon M. Cearley1, Vernon A. Barnes2, Santiago Junca3 1Charitable Medical Healthcare Foundation, Augusta, GA, USA 2Georgia Prevention Institute, Augusta University, Augusta, GA, USA 3Santiago Junca, Medical Illustration, Tucker, GA, USA Abstract Understanding the mechanics of consciousness remains one of the most important challenges in modern cognitive science. One key step toward understanding consciousness is to associate unconscious physiological processes with subjective experiences of sensory, motor, and emotional contents. This article explores the role of various cellular membrane potential differences and how they give rise to the dynamic infrastructure of conscious experience. This article explains that consciousness is a body-wide, biological process not limited to individual organs because the mind and body are unified as one entity; therefore, no single location of consciousness can be pinpointed. Consciousness exists throughout the entire body, and unified consciousness is experienced and maintained through dynamic repolarization during inhalation and expiration. Extant knowledge is reviewed to provide insight into how differences in cellular membrane potential play a vital role in the triggering of neural and non-neural oscillations. The role of dynamic cellular membrane potentials in the activity of the central nervous system, peripheral nervous system, cardiorespiratory system, and various other tissues (such as muscles and sensory organs) in the physiology of consciousness is also explored. Inspiration and expiration are accompanied by oscillating membrane potentials throughout all cells and play a vital role in subconscious human perception of feelings and states of mind. In addition, the role of the brainstem, hypothalamus, and complete nervous system (central, peripheral, and autonomic) within the mind-body space combine to allow consciousness to emerge and to come alive. This concept departs from the notion that the brain is the only organ that gives rise to consciousness. Keywords Membrane Potential, Unified Consciousness, Respiration, Thalamus, Oscillations How to cite this paper: Jerath, R., Cearley, S.M., Barnes, V.A. and Junca, S. (2017) The Dynamic Role of Breathing and Cellular Membrane Potentials in the Experience of Consciousness. World Journal of Neuroscience, 7, 66-81. https://doi.org/10.4236/wjns.2017.71007 Received: December 8, 2016 Accepted: January 22, 2017 Published: January 25, 2017 Copyright © 2017 by authors and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access R. Jerath et al. 67 1. Introduction This review article serves to introduce consciousness as a living entity that is maintained through respiration-the sum of the combination of not only the cells of the internal and external body, but also the cellular and biological processes that take place within the brain, eyes, heart, lungs, and intact body. We contend that 1) every mechanism within the body works in unison to bring alive the tripartite complexity of the mind, brain, and body through sensory organs, cardiorespiratory synchronization, and oscillatory activity, and 2) these activities collectively and seamlessly aggregate to create a homogenous consciousness experience. Here, we propose that consciousness is not located in or around a single organ, but rather permeates every cell of the body in reciprocal communication with the brain and central nervous system. The interconnected and interdependent relationship between the brain and body [1] as we will explain, happens in part through corticothalamic processes and varying polarity of cellular membrane potentials (see Table 1). Membrane potentials are one of the "defining characteristics of living cells", and changes in voltage regulate transduction Table 1. Varying resting membrane potentials. Cell Resting Membrane Potential Astrocytes 20 mV higher than surrounding neurons [6] Large peripheral nerve fibers −90 mV [7] Ventricular myocyte −90 mV [8] Nerve −85 mV to −90 mV [7] [9] Heart −85 mV [9] Glial syncytium −80 mV to −90 mV [6] Skeletal Muscle −80 mV to −90 mV [7] Spinal motor neuron −65 mV [7] All of soma −65 mV [7] Layer 5 pyramidal neuron −60 mV to −80 mV [10] Neutrophils −60 mV [11] Intestinal smooth muscle −50 mV to −60 mV-average is −56 mV [7] Olfactory cells (unstimulated) −55 mV [7] Primary Tracheobronchial Human Epithelia-Basolateral −34 mV [11] Liver −28 mV to −40 mV [9] Primary Tracheobronchial Human Epithelia-Apical −24 mV [11] Human Erythrocyte −8.4 mV to −4.5 mV [9] [12] Cellular resting membrane potential ranges from −90 mV (large peripheral nerve fibers) to −4.5 mV (red blood cell) but does not result from unbalanced ionic phase flow. Instead it measures the required work to move ions between phases [9]. There is a lack of evidence to support membrane potential in alveolar epithelial cells due to a lack of adequate culture models and complicated anatomy [11]. R. Jerath et al. 68 of signals [2]. We propose that dynamic membrane potentials at the cellular level, along with their modulations by inspiration and expiration, play a fundamental role in the experience of a consciousness that is not only unified [3], but is also perceived as a living phenomenon. Western thought emphasizes that consciousness is localized in the brain; however, Eastern thought suggests that the mind and body are one, as realized, for example via meditation and Samkhya-Yoga through introspection [4]. These practices provide experiences that lead us to suggest that not only consciousness is a body-wide experience, but also the mind and body are a homogenous entity linked by dynamic homeostasis [5]. 2. A Layered Consciousness Similar to technology and architecture, consciousness is built upon layers. A computer cannot execute the simplest of commands without bits and bytes; a skyscraper cannot be constructed without a strong foundation and proper support beams; analogously, consciousness cannot arise without the subconscious and unconscious physiology. Damage to these foundational layers can lead to partial or complete dysfunction of the whole [13]. There are three neural and non-neural layers that build upon one another in order for consciousness to emerge. The first layer consists of activity within the default mode network, resting state network, reticular activating system, cardiorespiratory system, and is dominated by slow (alpha) oscillations [6] [13]. This activity not only creates the foundation on which other oscillatory activity is built, it also forms the neural sensory memory space. Damage to this layer can lead to unconsciousness, coma, sleep disorders and autonomic dysfunction [6] [13]. The second layer is composed of limbic activity, emotions, feelings, gut and visceral connections, and includes activity from the limbic and cardiorespiratory systems. Theta and beta oscillations dominate this layer, and damage to this layer can contribute to emotional disorders, amnesia, and panic attacks [6] [13]. The third layer is attributed to higher processing and consciousness, and is also responsible for filling in the sensory memory space [6] [13]. Neural activity in this layer is received from cortical, corticothalamic, and cardiorespiratory areas and the dominating oscillations are alpha and gamma. Contralateral neglect, cortical blindness, memory loss (due to stroke), or sensory dysfunction can be the result if this layer is damaged [6] [13]. Each of these layers builds one upon the other, constructing the internal framework for a unified conscious experience through information integration with the thalamus via corticothalamic feedback loops. The conscious aspect of human behavior and moods are dominated by the unconscious and subconscious activities. For example, Kay et al. explained that in the rat, theta oscillations are not only referred to as respiratory oscillations, but that they are also "driven by sensory" input [14]. In another study by Zelano and colleagues, it was discovered in humans that nasal breathing modulated cognitive function by granting entrance into limbic areas of the brain, and could R. Jerath et al. 69 significantly influence "emotion discrimination and recognition memory" [15]. Furthermore, this study reported that breathing could "influence human cognitive processing", while rhythmic breathing patterns could modulate electrical brain activity patterns that regulate behavior, suggesting that there is a possibility that other processes in the body rhythms (i.e. physiological and autonomic) could "shape neural oscillations to optimize human perception, emotion, and cognition" [15]. The study implied that breathing is not simply a passive action mediated by stimulation or attentiveness, but rather it is a promoter of oscillatory synchrony and could "optimize information processing in the brain areas mediating goal-directed behaviors" [15]. These studies suggest that cognitive function and brain activity are both modulated by respiration, thereby supporting our theory that respiration helps facilitate consciousness. 3. Oscillatory Activity The behavior of oscillations at the cellular and subcellular levels directly result from negative feedback loops along with coupled positive and negative feedback loops, indicating that oscillations are the natural end-products of biochemical interactions within the cells [16]. As with facilitating processes associated with embryogenesis, oscillations during growth and adulthood modulate the function of organs and processes of life. Deviant oscillatory patterns can result in developmental defects and or disease [16]. We offer a new perspective in that: 1) oscillations such as cardiorespiratory and brain rhythms may be involved in energy metabolism to various organs [6], 2) oscillations and brain rhythms create an internal reality that allow one to perceive the external and internal world [6] [17], 3) the synchronization or de-synchronization of cardiorespiratory oscillations with the brain stem allow the emotional brain to determine the meaning of the visceral sensations of the chest and gut [18], and 4) corticothalamic oscillations include feed forward and feedback information from the senses that functionally allow a person the sense of awareness and to experience the external world. All cells of the body are electrically charged and connected via gap junctions to form an intra-personal space that subconsciously proxies for the external space that we have termed the "3D default space" [6]. Physiology of vision has been studied extensively, and we have proposed a new theory that highlights the primary role of the retina and lateral inhibition [19]. The synchronous oscillatory activity among the thalamic reticular nucleus, the retina, and various locations in the cortex allows one to see a seamless image that subconsciously proxies for external images. The thalamic reticular nucleus unifies the final focusing of the retinal images [19]. 4. Thalamus Information transmitted to the cortex is actively governed by the thalamus and the thalamic reticular nucleus, coupled by feedback from the cortex, thus making the thalamus important in cortical processing of peripheral information. This is because all information must pass through the thalamus [20], and sensory inR. Jerath et al. 70 formation must be filled in prior to conscious awareness [6]. The thalamus relays information to the cortex regarding the environment and internal processes, while the cortex communicates with the thalamus concerning output from multiple processing stages [21]. The thalamic reticular nucleus is a thalamic inhibitory agent, regulates corticothalamic networks excitability, and gives rise to some of the rhythms observed in sleep [22]. Neural responses are influenced by inhibition through interactions with membrane dynamics. For instance, relay cells can fire in rapid burst spikes or in tonic trains [23]. Rapid burst spikes occur during low membrane voltage (sleep), are unable to respond to new excitatory input, but are able to recover from inactivation by strong hyperpolarization, and may play a role in vision because they cause cortical excitement [23]. These spikes can transmit separate information from information encoded in single impulses [23]. Bursting increases with drowsiness or inattentiveness, suggesting that bursting acts like a wake-up call, which is significant for information that is relayed through the thalamus [20]. During waking behavior, thalamic relay cells experience tonic and burst firing; however, tonic firing occurs more frequently in alertness and during membrane depolarization (waking) [20] [23]. Cellular communication is supported by gap junctions, which are capable of generating gamma rhythms in inhibitory neurons because "cells with strong electrical coupling can fire synchronously at low frequencies", and they can assist with neuronal calibration in the visual cortex [24]. During sleep and waking states the membrane potential plays a fundamental role in thalamic neurons. Drowsiness begins at approximately −70 mV and full-blown slow-wave-sleep is induced at −90 mV [25], suggesting that the thalamus exhibits a lower membrane potential than does the cortex because of the ~20 mV difference between states of waking and sleeping. The difference in membrane potential leads to a change from alpha, beta, and gamma waves to delta waves during deep sleep when 1) the membrane potential is high [26], or 2) from faster rhythms during a waking state to low-frequency rhythms observed during slow-wave and rapid eye movement sleep [24] [27]; however, the role of various EEG waves is not known. During the waking state, the thalamus communicates with the cortex via reciprocal connections-which could be the basis of cognition, and the thalamus is in a mode of tonic firing, which is suspected to be the vehicle for information transfer from the thalamus to the cortex [28]. During slow-wave sleep the thalamus shifts to a burst mode of firing and is associated with the disconnection between the thalamus and cortex [28]. For further explanation on respiration and membrane potentials, please see our previous article discussing widespread depolarization during expiration as a source of respiratory drive [5]. Corticothalamic neurons in the lateral geniculate nucleus and pulvinar may be influenced by neurons in the thalamic reticular nucleus. Neurons in the thalamic reticular nucleus influence corticothalamic neurons in many ways, including: 1) reduction of spike rates via direct inhibition, 2) increase of responses via disinhibition via dendrodentritic synapses, and 3) switching/changing their firing R. Jerath et al. 71 modes resulting in how the cortex receives information [21]. Furthermore, it is possible that thalamic reticular neurons: 1) affect synchrony and oscillatory patterns of thalamic neurons, and 2) serve as a pacemaker of corticothalamic oscillations because the thalamic reticular nucleus is specifically positioned to assist in cortical synchronization [21]. Cholinergic input to the thalamus mediates alpha oscillations. Additionally, cholinergic inputs may change the synchrony of neurons in the lateral geniculate nucleus because this area contains different groups of neurons that fire at distinct phases of alpha oscillations [21]. 5. Membrane Potentials and the 3D Default Space The thalamus is an essential component in the process of consciousness because this hub receives and processes sensory and periphery information, then reprojects it into an external visual field, giving the impression that images and events are external [17]. However, we contend that this information processing must occur in order for a person to understand what is being experienced. The external world is merely a complex, internal recreation based on many factors including glucose and energy metabolism, neurotransmitters, efferent and afferent signals, memory, and attention processes that work together to form the experience of unified consciousness [6]. The three-dimensional (3D) default space is the intrapersonal space [6], which is brought into existence through the body's cellular unity and electrical communication-facilitated by gap junctions and messenger activity through intercellular fluid [29] [30] [31]. This 3D default space consists of the entire brain, body, communicating cells, and the neural sensory memory space [6]. We suggest that the rhythmic oscillations synchronize with those in the periphery and viscera. The neural sensory memory space is comprised of oscillations from the reticular activating system, the default mode network, and the resting state networks [13]. When the thalamus fills in this space with visual and non-visual representations, and processed sensory information, it allows consciousness to emerge [6]. The consciousness experience occurs when: 1) sensory information from the body and information from the neural sensory memory space is processed through corticothalamic feedback loops, and 2) the thalamus is able to receive and integrate this information to fill in into the 3D default space [6]. We speculate that the highest membrane potentials exist within the astrocytes and neurons located in the brain, and they send electrical energy over long distances (interneurons of the skin and muscles) where the membrane potentials are lower. The oscillations are generated by areas of higher membrane potential that move to areas of lower membrane potential, repeating the process over and over. Once the areas of lower membrane potential increase, the electrical energy moves to the brain where depolarization has occurred as the result of oscillations. This cycle occurs at all levels between the thalamus and cortex, as well as between the thalamus and peripheral neurons. The thalamus is able to communicate with all sensory organs, and perform memory and executive functions R. Jerath et al. 72 within 150 milliseconds [32]. We contend this occurs through a flow of back and forth parallel information processing, allowing a person to become aware of his/ her internal and external surroundings while awake. 6. ATP Formation and Respiration Cellular respiration in the mitochondria begins with glycolysis-the process in which glucose is broken down into pyruvic acid, forming adenosine triphosphate (ATP) required for energy [7]. The second stage of glycolysis is the citric acid cycle, and the third stage is the electron transport chain (ETC) [7]. The electrons are stored in the chain and allow for the regulation of potassium channels in both the mitochondria and cell membranes [33]. This membrane potential drives millions of cellular functions, suggesting that electrons are the currency used for cellular and organism survival, because mitochondrial potassium channels regulate mitochondrial respiration and alteration of membrane potential [33]. Energy is essential for: 1) motility, 2) sustaining life, and 3) establishing and maintaining a difference in electrochemical potential between the inside and outside of a cellular membrane-which allows the organism to receive or provide metabolites [34]. Glucose and oxygen create the electrons needed for the electrical potential through glycolysis within the mitochondria (where energy is derived)-and we suggest that all cells require electrical potential for survival. Energy metabolism could be affected by the interaction of slow synchronous oscillations, and cellular and molecular interactions within the body provide energy to neurons and astrocytes [6]. This creates a dynamic infrastructure that allows peripheral areas to transmit information to the thalamus, and to be processed through corticothalamic feedback loops within milliseconds [6]. Thus membrane potential occurs as a result of membrane bound respiratory complexes [34]. Previously it had been proposed that with inspiration the membrane potential of all cells increases, while during expiration it decreases [3]. The metabolic evidence of this correlates with ATP formation during oxygenation and decreases when oxygen availability is lower [35]. We adduce that during the formation of electrons in the ETC, tiny electrons are released, travel via gap junctions, and are directly transmitted to various cells, and thus each breath dynamically raises the electrical potential in the cells maintaining consciousness. Autonomic (metabolic) breathing (medulla oblongata and pons) is vital to all cellular functions by providing oxygen and energy to all the cells, and autonomic breathing directly corresponds with changes in emotions because of the complex interaction between the brain stem and the limbic and cortical structures [36]. Behavioral breathing has a direct effect on feelings, sense of self, and the emotions through synchronization between breathing and the emotion a person is feeling, because each emotion is associated with a specific breathing pattern [36] [37]. R. Jerath et al. 73 7. Respiration and Membrane Potentials Cardiorespiratory synchronization affects the autonomic nervous system and brain activity by increasing homeostatic membrane potential and decreasing intrinsic cellular excitability [5]. This demonstrates that 1) respiration influences brain activity, autonomic nervous system function, blood pressure, and heart activity, and 2) respiration governs homeostatic physiology [3]. This suggests that respiratory neurons in the brainstem are vital components in respiratory control because they generate breathing activity and participate in sensory responses such as fluctuations in oxygen and carbon dioxide. Respiration consists of an intricate web of intrinsic, synaptic, and modulatory properties that allow the respiratory network to continuously adapt to external and internal environmental changes [38]. Breathing can modulate behavior and behavior can modulate breathing [5] [38] [39]. We propose that breathing is a dynamic and global activity that releases and sends electrical impulses throughout the body (via slowly adapting stretch receptors), and due to the small size of these electrons, they are able to penetrate all of the body's tissues (see Figure 1). For example, breathing can modulate fear, arousal, and cognitive states; and vocalization, sleep, arousal, fear, exercise, hypoxia, or hypercapnia can modulate breathing [5] [38] [39] [40]. Respiration affects sympathetic and parasympathetic activity by decreasing or increasing cardiorespiratory coherence [3] [41] [42]; therefore, we propose that respiration allows for the constant, real-time communication between the brain and sensory organs. Inhibition in the cortex, thalamus, hypothalamus, amygdala and reticular activating system takes place during hyperpolarization and includes slow wave sleep [41]. During sleep, the membrane potential of the thalamus increases by ~20 mV, severing the connection between the thalamus and cortex [43]. The oscillatory change from alpha and gamma to delta shows a direct relationship between consciousness and membrane potentials, and specific oscillatory activity. We contend that membrane potential in the brain is like a switch, and increasing membrane potential-either through natural occurrence or by artificial means- renders a person unconscious, as seen in sleep. The role of respiration in how consciousness is maintained refers to consciousness being supported by both conscious and unconscious physiology, along with the layers of consciousness and unconsciousness that are powered by breathing [6] [13]. Our contention is that respiration causes the dynamic fluctuation observed in cells during repolarization and depolarization, and is vital in cellular function and oscillatory activity. Respiration influences the subconscious-where respiratory activity (through respiratory oscillations) is apparent in the limbic system, limbic cortex, hypothalamus, blood vessels and skin, and peripheral areas (heart and lungs) that are involved in subconscious emotion processing, and in consciousness, where respiration is involved in changes in brain waves [13] [42]. Each emotion has a specific respiratory pattern associated with it, and during inspiration, one is able to intuitively assess the feeling experienced at that moment [37]. The default mode network, cortical cells, and thaR. Jerath et al. 74 lamus are all supported by increased membrane potentials resulting from breathing, and in turn, respiration involved in carrying out shortand long-term activity of the cells [13]. Furthermore, inspiration and expiration are associated with fluctuations in membrane potentials changes that underlie the dynamics of rhythmic breathing [3]. Figure 1 illustrates membrane activity that occurs with inspiration. Breathing is an unconscious activity and normal respiration consists of 6 20 breaths per minute. During inspiration, an increase in electrical potential causes hyperpolarization in all the body's cells, shown with the white illumination . When inspiration takes place, the intake of oxygen induces cellular respiration which releases electrons from the electron transport chain into the lungs and surrounding tissues, including the heart, blood vessels, nerves, muscles and skin. With inspiration, immediate physiological changes take place: respiratory sinus arrhythmia in the heart, the Herring Breuer Reflex in the brain stem, hyperpolarization and inhibition of sympathetic neurons, activation of slowly adapting stretch receptors in the lungs, and oscillations that lead synchronization with brain waves. Figure 1. Membrane potential changes during inspiration. 8. Respiration and Sighing Sighing is associated with emotional states [44], such as is observed in states of anxiety where sighing is exaggerated [45]. Furthermore, evidence suggests that excessive sighing can exaggerate panic [45]. Sighing is also considered to be essential for an organism's survival. For example, in experiments using mice that were genetically engineered to lack the ability to sigh, it was found that the mice incapable of sighing died of major lung problems sooner than normal mice [45] [46]. Additionally, research suggests that sighing helps to reset normal breathing patterns, and can "activate the cardiovascular system...by imposing very low frequency oscillations" [44]. These studies support our theory that breathing is vital to cellular functions and oscillatory activity that influence unconscious activities of the heart and lungs that involve emotions. This is because the autonomic nervous system is modulated by increased membrane potential and "decreased intrinsic cellular excitability", and the cardiorespiratory system maintains membrane potentials of neural and non-neural cells throughout the body [5] [6]. 9. Breathing Brings Consciousness to Life We contend that the state or quality of awareness would not be possible without R. Jerath et al. 75 breathing. The ability to feel at any given moment is possible because the emotional circuits-composed of the limbic system, cardiorespiratory system, and gut-are activated by inspiration and expiration [36]. Cognitive functions performed by the brain such as wakefulness, sense of self, and the executive control system of the mind utilize nearly 20% of oxygen supplied by a large volume of blood (maintained at approximately 50 mL/100g of brain tissue per minute) [47], and 50% to 80% of the energy consumed by the brain is utilized in signaling associated with neuronal input and output activity [48]. Unconsciously, breathing activates all cells within the body including internal emotional circuits [36] thereby providing a person with a moment to moment and intuitive assessment of how one "feels". It is well known that during anxiety, breathing rates increase and are shallow, but deep breathing has been shown to help decrease anxiety states [39] [40]. Additionally, the role of rapid breathing is evident in hyperventilation (leading to panic attacks) [49] and breathing into a paper bag has shown to be efficacious in returning respiration to normal [50]. Evidence suggests there is a definitive link between the sympathetic nerve and breathing [51] [52]; therefore, we contend that more research should focus on the link between respiration and sub-threshold oscillations in various organs. 10. The Role of Meditation in Treating Stress Meditation practices including mindfulness-based stress reduction (introduced in 1979) and mindfulness-based cognitive therapy (introduced in 1995), have been shown to use meditation to "effectively manage and treat a range of psychological symptoms (anxiety, depression, emotional responses to stress)" [53]. These types of practices help a person develop the ability to accept his/her experiences instead of finding ways to avoid negative experiences/stimuli [53]. Furthermore, evidence confirms meditation helps to decrease stress levels and attenuate symptoms of: 1) depression, 2) anxiety, 3) negative coping, 4) negative affect, 5) somatization, 6) self-hostility, and 7) post-traumatic stress disorder [53] [54] [55]. Meditation also helps synchronize the heart with respiration. For example, during meditation, the ratio of heartbeats to breaths has been shown to be predominantly 4:1 and 5:1 through slower breathing patterns [56]. This induces a 'relaxation response', termed by Herbert Benson, which can cause instant physiological changes including decreases in: 1) oxygen consumption/carbon dioxide elimination, 2) heart rate, 3) blood pressure, 4) respiratory rate, and 5) sympathetic nervous system reactivity during times of stress [55]. These hemodynamic changes that occur in meditation result from slower breathing patterns and decreased heart rate, which synchronize the heart and lungs, creating a sense calmness [57]. Furthermore, meditation increases neuronal and cellular membrane potentials through cardiorespiratory synchronization, decreasing the intrinsic cellular excitability responsible for activity of the autonomic nervous system and brain [5]. R. Jerath et al. 76 11. Corticomuscular Coherence Corticomuscular coherence occurs in all muscles, suggesting a single connection in the complexity of oscillatory interactions in the cortex, thalamus, and cerebellum [58]. Corticomuscular coherence is highly regarded as the method to directly measure the relationship and connection between cortical and muscular activities, and electrophysiological signals are used to measure oscillatory activity within the brain [59]. Corticomuscular oscillations at ~10 Hz indicate brainmuscle communication, beta band oscillations (13 30 Hz) are associated with controlling less than maximal muscle force, and low gamma band oscillations (30 60 Hz) are associated with controlling the production of stronger muscle force [59]. Electroencephalography and magnetoencephalography measure corticomuscular coherence, and the phase locking of oscillations between brain and muscles [60] supports our theory in that peripheral activity is unified with central activity in real-time. This is because synchronous oscillatory activity of alpha, beta, and gamma activity is fundamental for motor control [61]. For example, in experiments using healthy subjects performing isometric muscle contraction tasks, transcranial alternating current stimulation revealed that alpha and low gamma band activity 1) affected one other, and 2) modulated motor cortex and muscle interactions when working together [61]. It is known that gamma oscillations reflect cognitive functions and voluntary motor activities [59]. Coherence of gamma frequency band persists during slow movement, and studies have reported a decrease in the gamma band coherence in patients who did not recover well from stroke [59]. It is thought that lower corticomuscular coherence reflects either a lack in brain-muscle communication, or poorly integrated signals between the brain and muscles during motor actions [59]. We suggest that the brain, astrocytes, neurons, interneurons, heart, and periphery (sensory organs and limbs) pulsate at nearly the same frequency as the brain, which in turn, allows a person to respond and react to the external world in real time. For example, it is known that beta band oscillations in the somatosensory cortex are synchronized with the motor cortex oscillations, which allow oscillatory sensory reafference to correctly interpret oscillatory motor commands [62], and the motor cortex oscillates in the beta band frequency of about 20 Hz with the muscles contracting contralateral side of the body [62]. Additionally, it has been shown that subthreshold oscillations are evident in membrane potentials of primary sensory neurons in rat dorsal root ganglia cells [63]. These oscillations were voltage sensitive in amplitude, frequency, and coherence, and it was discovered that upon reaching threshold, oscillations gave rise to action potentials [63]. Furthermore, oscillations influence biochemistry and could play a role in diabetes mellitus [64], and aberrant oscillatory patterns have been shown to be concurrent with severe disease and defects (i.e. primary ciliary dyskinesia), or play a significant role in the development of other disorders due to disruption of cellular oscillations that regulate the circadian clock (i.e. R. Jerath et al. 77 metabolic syndrome and cognitive disorders related to schizophrenia) [16]. These studies suggest that oscillations play a significant role in internal functions of the body, which affects the consciousness experience. 12. Conclusion This article presents evidence from studies on oscillations, respiration, and membrane potentials to support a theory that consciousness is body-wide biological process not limited to individual organs. Current research regarding the location where consciousness emerges is at best, a fragmented approach. 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