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Most afternoons Hubby is home by 5:30pm. In Summer that means if we are fast there is an hour or two of usable light before it gets dark. Sometimes we just lay about in the backyard and have a chat, sometimes there are errands to run or food to buy. More often than not I make sure that should we go running these errands, I whack on a little more make-up, fix the do and pack the camera. This practice has meant we have captured some awesome afternoons with just us too. Him with dirt still on his face from a day at work. Me with my more standard every day outfits. Being dorks. They are my favourites.
So here's another of those type afternoons.
With my stripe bonds tee tucked into my maxi skirt you've seen a million time. Throw on some neon accessories and what's old is new again, right? I read somewhere today that recycling your clothes will be a big trend in 2013. Frugal fashionistas? Yeah, I'll wait and see on that one. But it is great news for me who recycles items all of the time. ALL of the time. So go me, how very fashionable. And since it's all fashionable and the like, I'm going to embrace it like never before. So watch me shop my wardrobe folks. 2013, the year of the frugal fashionista. You heard it here first.
You shop your wardrobe, right?
Tee – Bonds
Skirt – Lily & Lou for Best & Less
Flats – BigW
Earrings – Lovisa {$3 in the sales, gift from my sis & sil}
Bracelet – Sportsgirl
{no brand associations currently exist}
Chief Blogger at Suger Coat It; An Australian lifestyle blog for women who work for themselves. Melissa is a social media consultant & lover of stripes. Most weekends you'll find her at the beach or home on the veranda kicking back. Around here, they call her Suger. Feel free to do the same.

subset: commoncrawl


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1654P - NSCLC Patient Immune Cell Profiling and Response of Tumor Antigen Specific CD8 T Cells to Checkpoint Receptor Antagonists
|11 September 2017
|ESMO 2017 Congress
|Poster display session
| Immunotherapy
Thoracic malignancies
Translational Research
Basic Principles in the Management and Treatment (of cancer)
|Junghee Lee
|Annals of Oncology (2017) 28 (suppl_5): v573-v594. 10.1093/annonc/mdx390
J. Lee1, X. Wu2, L. Liu2, M.D. Breyer2, H.K. Kim1, J.H. Cho1, J. Lee3, Y.S. Shin3, J. Kim1, Y. Zhao2
The breakthrough in cancer immunotherapy of targeting PD-1 or PD-L1 and enabling T cells to attack tumor has opened new window for cancer treatment of many tumor types. Many of these immunotherapeutic approaches involve targeting specific immune checkpoints. To better understand the role of checkpoint receptors in cancer immunotherapy and explore new treatments, we analyzed cancer patient PBMCs and dissociated tumor samples from non-small cell lung cancer (NSCLC).
Transcripts of Cancer Testis (CT) antigens (NY-ESO-1, MAGE-A1, and MAGE-A3), a novel T cell inhibitory checkpoint receptor (TIGIT), and its respective ligands (PVR and PVRL2) as well as PDL1 from a cohort of NSCLC patients was analyzed. Immune cells from these patient samples were profiled and NYESO1/HLAA2 tetramer was used to detect NYESO1 specific CD8 T cells in HLAA2+ patients. Intracellular cytokine secretion was analyzed using a specially designed multiparameter flow cytometry panel for both general and NYESO-1+ CD8 T cells.
The correlation between CT antigens, immune checkpoints, and effector T cell signature (CD8A, IFN-gamma, and Granzyme A) may help us understand 1) why certain patients have inflamed tumors and others have "cold" tumors; 2) why certain patients respond to anti-PD(L)1 therapy and others do not respond. Antibodies targeting both PD1 and another novel immune checkpoint receptor TIGIT showed best stimulatory effect on both antigen specific CD8 T cell number and intracellular IFN-gamma staining of those cells.
The data suggest that immune checkpoint receptor antibodies can be screened in real patient immune cells. Cotargeting multiple immune checkpoint receptors may provide superior efficacy to targeting single immune checkpoint receptor.
Clinical trial identification
Not applicable
Legal entity responsible for the study
Eli Lilly and Company
Eli Lilly
All authors have declared no conflicts of interest.


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the artist as inventor
artist's biography>
angles of incidence (works)
steaming and streaming
> watched/measured>
next memory city
very nervous system (vns)
bending the mirror>
vn bedfellows>
synthetic sensualism
> artifical perception>
creativity principle>
angles of incidence (works) : steaming and streaming
View this article in flash requires flash 6 >
steaming and streaming
Interactive Artists Tapio Mäkelä and David Rokeby Explore Bathing as a Cultural Interface
by Angus Leech
David Rokeby doesn't collaborate with other artists very often, but teaming up with Finland's Tapio Mäkelä to build a digital sauna installation at the Banff Centre was a great chance to generate cross-cultural dialogue that Rokeby didn't want to miss.
A hot bath! How exquisite a vespertine pleasure, how luxurious, fervid and flagrant a consolation for the rigours, the austerities, the renunciations of the day.
-- Rose Macaulay, Personal Pleasures
I was happy, there in the crazy dark, with the lost peaks,high and broken all around us, and the wounded slope of Sulphur Mountain pouring its blood into visitor's dreams.
-- Robert Kroetch, (Alibi)
If there's one element that Banff and Finland share in abundance, it's steam: spilling from the hot springs of Sulphur Mountain in the first instance, wafting from the doorways of traditional Finnish saunas in the second. So perhaps there's some poetry in the fact that Canada's David Rokeby and Finland's Tapio Mäkelä chose The Banff Centre's 2002 Up Front and Personal artist's residency as the place to hammer together (literally) their new collaborative project, Steamingmedia.org. Over several weeks of inclement Spring weather, the two interactive artists laboured beside the Sally Borden pool to construct a portable three-person wooden sauna wired with a few digital enhancements. This was the first production phase in a grander plan to tour Steaming Media installations around the world over a span of several years, starting in early 2003.
Steamingmedia.org will consist of two special saunas linked together over both geographic space and cultural difference. In each of two remote locations, saunas equipped with real-time Internet streaming features will communicate sound, blurry steamed-up video, and environmental data between installations. As Rokeby and Mäkelä explain in their artists' statement:
One wall consists of a rear projection screen, which shows the interior of a second, remote Steaming Media sauna located in some other country or location bathers can see remote co-bathers through a blurred, steamlike video image (reducing the sense of voyeurism, but reinforcing the sense of proximity) and enter into a dialogue with them.
The project will also connect sauna experiences through time, by layering archived audiovisual recordings from previous bathing sessions into the live portion of the experience. This temporal convergence will be interactive in the sense that it will be linked to the degree of "steaminess" detected by environmental sensors hidden within the sauna's confines:
(T)he act of throwing water on the stove produces a hiss of steam, and as the resulting burst of warm humidity reaches the bathers, it draws a chorus of groans and expressions of pleasure. It also generates a distinctive temperature and humidity signature, which our system can identify. These distinct signatures are used to launch appropriate pre-tagged media files from the archive. This system will not be intrusive, but rather acts as a moderator of the current sauna session, waiting for lulls in the conversation before intervening in an attempt to stimulate further discussion.
Steaming Media's time-machine element will also function full-time if there is no one to talk to at the sauna's distant end, taking bathers on an audio-visual journey through sympathetic environmental states instead. Meanwhile, bathers who crave more interactivity, or a cool respite, can follow Finnish tradition and take a dip in the swimming pool situated alongside each sauna, which will be rather un-traditionally rigged with under-water versions of David Rokeby's Very Nervous System. The submerged cameras of VNS will transform swimmers' movements into responsive music, converting the pools into interactive soundscapes that, just like the saunas, are telematically connected to one another:
The video stream is analyzed by softVNS software...and the results of the analysis and similar information from the remote pool are used to compose the unfolding interactive sound environment played through speakers in the water and above the surface. Each pool can function autonomously, but when swimmers are active in both pools, the local and remote swimmers can interact allowing each swimmer a tangible sense of the other. The pool and sauna should be fairly close to each other so that reflections on the pool experience can also be shared in the sauna discussion.
The intention of Steamingmedia.org is to merge the intimate conversation and heightened bodily awareness of the traditional Finnish sauna, with the possibilities for cross-cultural dialogue provided by telematic communication systems, and the body-oriented human-computer interactions made possible through VNS.
Each of the two or more saunas that Rokeby and Mäkelä construct will be fully portable and collapsible, designed to be fit into shipping containers and rebuilt somewhere else. The artists will be able to tour their installations from institutions like The Banff Centre and Finland's Kiasma Museum (another project sponsor) to electronic arts festivals like Toronto's IMAGES and Holland's DEAF 2003, where it is hoped that Steaming Media will launch. Thus Steamingmedia.org is likely to become a meeting place not jusst for divergent cultures, but common interests in the media arts as well. Though there will eventually be limited online and gallery components to the project, the main intent will always be to bring unique choruses of people together across time and space, and watch their interactions steam.
Angus Leech is the Assistant Editor of HorizonZero.


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Ugo Introini, Giuseppe Casalino, Ana Torres Gimeno, Fabrizio Scotti, Silvia M. Giatsidis, Francesco Bandello; Intravitreal Ranibizumab And Exudative AMD Subtypes: Results In A Clinical Setting. Invest. Ophthalmol. Vis. Sci. 2012;53(14):859.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: :
to compare functional outcome of patients with choroidal neovascularization (CNV) or retinal angiomatous proliferation (RAP) secondary to age-related macular degeneration (AMD) treated with intravitreal ranibizumab in a clinical setting.
Methods: :
we reviewed the medical records of consecutive patients that received three initial monthly injections of ranibizumab and thereafter underwent monthly controls with treatment as needed (PRN) and completed 1-year follow-up. Baseline examination included best-corrected visual acuity (BCVA), fundus biomicroscopy, Spectral-Domain optical coherence tomography (SD-OCT), fluorescein angiography and indocyanine green angiography. Primary treatment outcome measure included changes in mean BCVA, expressed as a logarithm of the minimum angle of resolution (logMAR). Secondary treatment outcome measure showed changes in mean central retinal thickness (CRT).
Results: :
87 eyes of 83 consecutive patients were included. Mean baseline logMAR BCVA was 0.34±0.19 in the CNV group and 0.37±0.25 in the RAP group, ranging between 0.70 and 0.00 logMAR (20/100 - 20/20) in accordance with local rules. Eyes with CNV (58 eyes) presented predominantly classic (PC, 11 eyes); minimally classic (MC, 10 eyes) and occult with no classic (ONC, 37 eyes) subtypes. The RAP group (29 eyes) included eight eyes with stage I, eight eyes with stage IIA (without retinal pigment epithelial detachment-PED), and thirteen eyes with stage IIB (with PED). Among CNVs, baseline and month 12 mean logMAR BCVA were respectively 0.41±0.24 and 0.37±0.19 for PC; 0.33±0.16 and 0.37±0.21 in MC; 0.33±0.19 and 0.36±0.25 in ONC. In the RAP group, baseline and month 12 mean logMAR BCVA were respectively 0.23±0.21 and 0.22±0.17 for stage I; 0.32±0.18 and 0.20±0.05 for stage IIA; 0.49±0.24 and 0.62±0.39 for stage IIB.
Conclusions: :
in our sample of patients with exudative AMD, a subgroup analysis of newvessels is a critical factor in the varying outcome in ranibizumab treatment. Retinal angiomatous proliferations, although considered lesions with a poor prognosis, showed in stages I and IIA, encouraging functional response to ranibizumab compared to MC and ONC CNVs. On the contrary, the presence of a RAP with PED (stage IIB) worsened the functional outcome. Further studies are mandatory.
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|New Zealand Immigration
Working in New ZealandThere are four main entry options available to people who wish to come to New Zealand to live and work.
Skilled Migrant
Qualifications or relevant work experience are required to enter New Zealand by this points based system, as well as a job offer from a NZ employer.
Work to Residence
For applicants that work in a highly specialised or "in demand" field or have an exceptional talent in sport, culture or the arts.
Temporary Work Visa
This allows the entrant to gain work experience in New Zealand or enter to work for a particular event or to take up a job offer from a New Zealand employer.
Working Holiday
Applicants from one of 23 countries (including the UK and USA) who are aged between 18 and 30, may travel to New Zealand to holiday and take up temporary work.
appointed by Accurate Immigration are Regulated by the New
Zealand Law Society.
The information on this page is intended to be general in nature and should not be construed as applying to the reader's individual set of circumstances. It does not constitute legal advice. Eligibility requirements and the application of laws vary on a case-by-case basis. Furthermore, Immigration laws, regulations and policies are always subject to change at any time without advance notice.
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Every couple dreams of having their own house and a luxurious car. But, purchasing a luxurious car is not an easy thing. Still, if you have promised your partner to take her away in your world in a luxurious car, on the day of your wedding, then you don't have to buy it. You can simply hire it. This post discusses how luxury car rentals have become the most sensible things to do for weddings.
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Should you buy the Bharat 22 Exchange Traded Fund
After successful launch of Central Public Sector Enterprises (CPSE) exchange-traded fund (ETF) in May 2014 and two subsequent follow-on offers in February and March 2017 worth roughly Rs11,500 crore, the government is divesting shares of another set of companies. It has appointed ICICI Prudential Asset Management Co. Ltd as the fund manager and the new scheme is Bharat 22 ETF (B22 ETF).
B22 ETF will hold shares of 22 companies. Rather than divesting its stake individually, it has chosen the ETF route. The money in B22 ETF will be transferred to the government and an equivalent value of shares of these 22 companies will be transferred to the fund.
The S&P BSE Bharat 22 index has been specially created to track the basket's performance. The index will comprise shares of the 22 companies in B22 ETF. No individual stock in the index—and thereby B22 Etf—will be more than 15% of the index and no sector more than 20%.
Although B22 ETF is different from CPSE ETF, comparisons are inevitable. B22 ETF scores over CPSE ETF on a few counts. First, it is more diversicount fied. CPSE ETF had just 10 stocks. Nearly 60% of CPSE ETF'S holdings are in the energy sector. B22 ETF also has three private sector firms—larsen & Tourbo Ltd, ITC Ltd and Axis Bank Ltd, where the government holds stakes. B22 ETF'S expense ratio is just 0.0095% every year, for a period of 3 years. After that it can change. CPSE ETF'S expense ratio is 6 basis points. This means, a Rs10,000 investment will result in a cost per year of 0.95 paisa in B22 ETF. One basis point is one-hundredth of a percentage point.
This is a large-cap fund and has a closer relation to the broader indices than the CPSE ETF mainly on account of the fact that the three largest holdings in B22 ETF are also part of the mainstream indices, so movements in those indices will better reflect in B22 ETF than in the CPSE ETF.
When CPSE ETF was launched, the government had made it attractive with a dis- and bonus units. B22 ETF offers a lesser discount and no loyalty bonus units.
The government will transfer the shares to B22 Etf—and thereby the investor—at a discount of 3%. This was 5% when the first tranche of CPSE ETF was launched in May 2014. The first and main offering of CPSE ETF had offered one bonus unit for every 15 units held to those who remained invested for a year since the new fund offer (NFO).
Since its inception, CPSE ETF has returned 20%—against an average of 27% by large-cap funds and an average of 31.7% by multi-cap funds. In 2016, when S&P BSE Sensex returned 2%, large-cap and multi-cap funds had returned 4.5% and 5.1% respectively, CPSE ETF returned 17.4%. Like with CPSE ETF, expect bouts of volatility in B22 ETF as both are thematic funds. But the presence of three large private-sector companies helps.
This is not a scheme for beginners. But if your core mutual funds portfolio is adequately diversified, you can look at it. It doesn't carry a lock-in and capital gains, if any, after 1 year are tax-free. If you buy it, we suggest you hold on for at least 3 years for the government policies to be implemented, especially in sectors that this fund invests in. Remember, to earn the discount of 3%, you need to invest in the NFO period.


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Words containing basang
Found 1 words containing basang. Browse our Scrabble Word Finder, Words With Friends cheat dictionary, and WordHub word solver to find words that contain basang. Or use our Unscramble word solver to find your best possible play! Related: Words that start with basang
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most of you would of seen I had my first scan on Monday.. thinking I was 7 weeks! Was only 6. Been at the hospital tonight from stress and bleeding, and everything is good!! They did a belly scan and we seen a fast heart beat at 6w 3d!! Sooo relieved
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Heart beat!
Staceyy1111 12/07/18
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You must feel so much better seeing that. I'm glad to hear everything is going well.
Original poster
In reply to Mumma__198912/07/18
You must feel so much better seeing that. I'm glad to hear everything is going well.
Thank you ❤❤
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SAG Awards have been one of the major award events in Hollywood since 1995, organised every year combining the awards come from two committees, one for film and one for television.
Honouring the best achievements in film and television performances for the year 2017, the 24th Annual Screen Guild Awards were presented on January 21, 2018.
The award ceremony was hosted by actress Kristen Bell, who was the host for the first time in its 24-year history.
24th SAG Awards focused on women, with an agenda of almost all female presenters.
Let's take a look at the winners of 2018.
Gary Oldman won the outstanding performer award in leading role for males for his movie 'Darkest Hour' in which he played the role of Winston Churchill and on the female side, Frances McDromand grabbed the award for her awesome performance in 'Three Billboards Outside Ebbing, Missouri' as Mildred Hayes.
For the best supporting role in the male actor category, Sam Rockwell won the award for the role of Jason Dixon in 'Three Billboards Outside Ebbing, Missouri' while in female category Allison Janney grabbed it for 'I, Tonya' as LaVona Golden.
In the category of stunt ensemble, the award goes to the hands of Wonder Women, Baby Driver, Dunkirk and many more.
For the television categories
Alexander Skarsgard won the Award for the role of Perry Wright in 'Big Little Lies' in the male category and in the female category, Nicole Kidman as Celeste Wright in 'Big Little Lies' won the award.
Apart from the awards, the SAG red carpet caught the attention of fans eager for a look of their favourite star dressed to the nines.
Aussie star Margot Robbie
Nicole Kidman
Susan Sarandon
Dave Franco and his wife Alison Brie
September 19 , 2018
September 19 , 2018
September 19 , 2018
September 19 , 2018
September 19 , 2018


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Curfews essay
Curfew law argument essay to a teenager a curfew law is just another reason for police to pull you over at night whether anyone wants to admit it or not, it is also another. 2011-02-04 shaun hiew 3/12/2010 english 9 should curfews be imposed on teenagers should there be a curfew imposed on teenagers many people believe that the. 3 essay about curfew social psychology paper - 786 words has made new friends, she wants them to like her and keep inviting her to go places with them. Check out our top free essays on curfew essays to help you write your own essay. It is important to establish a reasonable curfew that helps your teen be responsible and stay safe during the evening hours advice on curfews for teens.
Our depot contains over 15,000 free essays read our examples to help you be a better writer and earn better grades. What is an argumentative essay myrtle is a teenager whose parents have set a curfew for her, but she wants to stay out longer she thinks that she might be able to. Since the 1990s, millions of teenagers have been arrested for breaking curfew, which a policy analysis shows has a disproportionate impact on minorities.
Does anybody know what's a good fact about curfew i'm writing a persuasive essay why there should be a curfew for example 58% of violent crimes occur at night. Need essay sample on curfews doesn't keep teens out of trouble we will write a cheap essay sample on curfews doesn't keep teens out of trouble specifically. Teen curfew laws are in place for a reason many teens and advocates are challenging local ordinances as to their constitutionality.Read curfew essays and research papers view and download complete sample curfew essays, instructions, works cited pages, and more. 2003-06-26 tessa jowell a curfew is an order or a law that requires people to be indoors after a certain time curfews are set in place to keep and maintain public order curfews are set by guardians so teenagers can return home by a specific time curfews are specific deadlines that mark a period of ending. Yes the use of child curfews can help to protect vulnerable children although responsible parents do not let young children out in the streets after dark, not all. Child curfews can help to change a negative youth culture in which challenging the law is seen as desirable and gang membership an aspiration. 7 thoughts on " are curfews effective when keeping teens out of trouble " btm5243 october 23, 2015 at 11:32 am cool blog and interesting topic. Great collection of paper writing guides and free samples ask our experts to get writing help submit your essay for analysis. Persuasive essay : oppose curfew essayscurfew who wants a curfew now-a-days issued by higher authority not me is it not enough that our parents have there right to. Essay curfews, and other limits many parents set up rules, and other boundaries in which their teens must follow these rules are usually placed over.
But the enactment of curfews limits adolescents from achieving their goals curfew is a set time when teenagers are prohibited on the streets others feel that curfews are unconstitutional and take away children's independence in society some teenagers have legitimate reasons to be out after curfew. Do curfews keep teens out of trouble i believe that curfews can keep teens out of trouble but it can also encage them from the nightlife but then isn t it. Unlike most editing & proofreading services, we edit for everything: grammar, spelling, punctuation, idea flow, sentence structure, & more get started now. The topic of teenager curfews is usually a controversial one parents impose curfews to protect their teens, and teens often feel this is an unfair.
- A curfew is needed for people who stay out late and cause mischief towns without a curfew have higher crime rates than those who refuse or do not have a set curfew.
- Students under the age of seventeen have a curfew of 10 pm sunday through thursday and 12 am on friday and saturday the curfew ensures that all students should have.
Teen curfews by dr kenneth shore curfew is a frequent topic of friction between parents and their teen-aged children parents set curfews in an effort to keep. 2007-12-12 view and download curfew essays examples also discover topics, titles, outlines, thesis statements, and conclusions for your curfew essay. Writing anxiety do curfews keep kids out of trouble essay writing thesis proposal masters time travel essay.


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We can offer you stunning aerial photography or video of any site using state of the art drones, opening a new visual world to you or your clients.
Welcome to Dragon UAV Aerial Photography & Video
Dragon UAV strives to be one of the Wales' Top Providers of Drone and specialist media including 360 video, hyper-lapse, interactive aerial tours and more.
Our mission is to utilise UAS technologies as a means to provide innovative tools & methods to business for marketing, research, surveying and overview.
Based in Wales, but available across the UK.
Please take a browse around, visit the portfolio in "our work" and contact us to discuss your ideas !
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Our stunning aerial photography can place a property and its full grounds in its surroundings. We create the emotional connection that sells.
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Inspect potential sites, manage and control on-site assets and H&S. Monitor progress, assist in planning and marketing, from single builds to large civil engineering contracts.
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Cover your events by drone with amazing high-resolution video or photos. We can create 360⁰ panoramas from the ground up to 400ft, viewable in virtual reality headsets for a truly immersive and amazing experience!
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Reduce expenditure, turnaround time and risk by using our 4K footage and high-res stills to survey and inspect at height. No scissor-lift, scaffold or rope-access.
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"Being a drone pilot is far more than simply flying a camera. A passion for the technology, an eye for composition and construction of images that show the subject in an amazing and revealing way come with experience. Its our job to help sell your home, survey your site, surpass your expectations.."
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Price: £8.00
Publisher: London : Swan Sonnenschein & Co: 1906
Seller ID: 37209
Hbk no d/w, Vg-, 8vo, Red boards/spine with black decor and writing, pages browned, name on fep. View more info
By: Gatty, Margaret; Illus Woodward, Alice B.
Price: £20.00
Publisher: London; Bell; 1923:
Seller ID: 23444
H/b; monochrome illus boards; g; 8vo; 210pp; ball point scribble on back cover; heavily foxed edges, spreading to pages; worn appearance; nice illustrations; View more info
By: Illustrated by E. Dorothy Rees & Halsey, C Et Al
Price: £10.00
Publisher: London, Arandar Books, Nd: N.D.
Seller ID: 57842
4to Bright yellow pictorial boards. Front cover (illus by E. Dorothy Rees) shows children and a dog in a boat. Colour frontis of the Xmas Party; . B/w illustrations; generally Vg, but small picture on title page neatly coloured in; also the sun on 1 page coloured in; belongs to box is empty; covers slightly grubby; Vg-; ; 4to 11" - 13" tall View more info
Price: £10.00
Publisher: London; Pickering & Inglis:
Seller ID: 36554
H/b; vg-; 8vo; 159pp; ; 8vo 8" - 9" tall View more info
By: Jones, Mary Alice & Doane, Pelagie (Illus)
Price: £6.00
Publisher: London: Collins, 1966 rep: 1966
Seller ID: 29573
4to hbk in d/w; church stamp in book, and remains of sticker on fep; d/w has closed tear near top of spine; lovely illustrations; Vg-/Vg-; 4to 11" - 13" tall View more info
By: Sharp, David.
Price: £12.00
Publisher: London : Hampton House 1976:
Seller ID: 42469
Hbk, 4to, Vg-, multi-colour spine black/orange writing, pages browned slightly; 4to 11" - 13" tall View more info
Price: £6.00
Publisher: UK, Blackie,: 1950
Seller ID: 22521
Non; 8vo 8" - 9" tall View more info


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Visitors of the Show were able to complete a detailed questionnaire on the Breed Selector presented by Bow Wow Meow. The program then compiled all of the information and offered recommendations on the most suitable breeds for the visitor's lifestyle.
Some of the questions that were designed to help users find the perfect breed for them covered areas such as: location, if you have a backyard and if your property is secured. They also touched on the personality types and features you are looking for in your new best friend and how often you can exercise your Pooch. Other considerations like the length of time your Dog would be left alone, if you have small kids and if you have the time to dedicate to training were asked to ensure all aspects of your life are considered before users make the lifelong commitment to their new family member.
The objective was to find the right home, environment and human parents for Dogs too so they can live a long, healthy and happy life.
Once visitors were provided with the breed recommendations they then had the option to speak directly to the Breed Clubs exhibiting and actually meet the Dogs at the Show and the people who live with them.
Dogs come in all shapes, sizes and personalities, so if you were looking for a new puppy, adult or rescue Dog then Bow Wow Meow's Perfect Match feature was there to help provide a lot of the information you need to consider to help find the right Pooch for you and your family.


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2017-11-13 (316 Days Old)Total Views: 45 | Last 7 Days: 0
Decision to open investigation comes after female employee of security agency who filed complaint testifies, undergoes polygraph
The post Senior Shin Bet officials said investigated for sexual assault appeared first on The Times of Israel.
Haaretz: Israeli couple, son and five others indicted for pimping and trafficking women
Ynet: Trump to hold news conference on Wednesday after UN gathering
Ynet: Macron at UNGA: There's no credible alternative to two-state solution
Ynet: Incendiary balloons from Gaza cause 12 fires
WashingtonPost: Former Trump hotel in Panama City rebranded as JW Marriott
WashingtonPost: How Washington insider Doug Heye ended up on a date with comedian Sarah Silverman
FOX: College football running back forced to retire over neck condition
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FOX: College football running back forced to retire over neck condition
CBS: Newborn syphilis cases in U.S. reach 20 year high
BBC: Workman electrocuted while carrying out school repairs in Kilwinning
ABC: UK Labour Party criticizes Israel amid anti-Semitism warning
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Daily Mail: Duchess of Sussex attends the opening of a major art exhibition
NBC New York: DA: Man Arrested for Neglecting Dog to Point of Emaciation


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The Best of TimesMillions of songs. Thousands of games. Countless hours of fun. The new iPod touch has it all.
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$35.00Annie Lee At Ease 15 7/8 x 22 1/2 Product Details
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To order your stand alone prints or framed artwork simply stop by one of our 2 locations or call our Union, NJ location at
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If you are not located nearby we offer shipping. Shipping charges are based on size weight and location.


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Not available with current selections
Product Highlights
Compatibility: DesignJet T2530DesignJet T2530 DesignJet Z5200
Electronic Download
This item is noncancelable and nonreturnable.
You Pay: $3,099.00
Limit your downtime and keep your DesignJet T2530 Printer in working order with this 5-Year Next Business Day Onsite Hardware & DMR Support package from HP. It covers materials for onsite hardware support and includes remote problem diagnosis, escalation management, and access to electronic support information. Also, defective media retention allows you to keep your media for secure disposal based on internal protocols.


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Peer reviewed
ERIC Number: EJ224916
Record Type: Journal
Publication Date: 1980-May
Pages: N/A
Abstractor: N/A
Reference Count: N/A
The Role of Values in the Counseling Situation.
Rokeach, Milton; Regan, John F.
Personnel and Guidance Journal, v58 n9 p576-82 May 1980
Reviews various meanings of values and the authors' preferred distinction between terminal and instrumental values. A case illustration describes the usefulness of the Rokeach Value Survey. Research on the value survey is reviewed. C. Gilbert Wrenn gives his personal reactions. (Author)
Publication Type: Journal Articles; Information Analyses; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Identifiers - Assessments and Surveys: Rokeach Value Survey


text: This One's a Stretch The Time Treadmill Ron Miles 4th DoctorRomanaRomana I Nov 12 2017 Good news, everybody! My bounce back has bounced back. After setting a record low weight last week following an astounding amount of weight loss in under two weeks, I spent the past four days with my weight inching back up in a the expected bounce-back. Today, however, it dropped back down again. Not quite the record low, but enough to show that the overall loss was not a fluke. So that's nice. Also, I have been doing a planking challenge, and this morning I lasted for ninety full seconds. Two weeks ago I could barely hold for ten seconds. I am very pleased. My intention is to spend the rest of November focused on core strength, and then in December I will begin to work on upper body strength. Trust me, all the time on the treadmill has my lower body doing just peachy. Also, I finished the current story today, so let's talk about that. The Power of Kroll - Parts 3 & 4 (TARDIS Data Core recap) The Doctor, Romana, and the gun runner Rohm Dutt spend most of the third episode tied up on a rack, sentenced to a slow and painful death as the vines holding the blocks at the head and foot slowly dry out and constrict. It was dramatic and all, but I could help but feeling that the Doctor (being significantly taller than the other two) should have been completely comfortable while his shorter co-victims were stretched to their limit. Physics aside, they of course manage to escape their fate due to the combination of a fortuitous rainstorm plus the Doctor's ability to shriek at the perfect pitch to shatter the overhead window. One funny bit during that scene was a throwaway line by the Doctor about firing the architect. Why is that funny? Because the BBC's Head of Serials hated the set designs for this story and issued a decree that designer Dog Giles would never work on the series again. Oops. Honesty, though, I thought the sets looked just fine all around, certainly no worse than in any other story of the era. Anyway, the lead at the mining operation gets progressively more paranoid and bloodthirsty, and when one of his staff dares to question his orders the commander shoots the other engineer in cold blood and threatens the only other remaining employee with the same if he doesn't fall into line. It's not exactly a sad thing when one of the natives runs a spear through him during the final showdown. The big not-surprise of the story is that the giant squid-god Kroll was actually a garden variety giant squid who had the good fortunate to swallow the fifth segment of the Key to Time, which caused Kroll to grow to an immense size and live for hundreds of years. In the end the Doctor does a Very Clever Thing which results in Kroll just kind of melting away and leaving behind the key segment. The lone surviving human is left behind with the natives to await rescue from the home world, whilst the Doctor and Romana traipse on back to the TARDIS with the penultimate piece. Poor K9 never even makes an appearance. On the whole this was a rock-solid story and lots of fun to watch. The middle part of this whole Key to Time business was getting to be a bit of a disappointment, but this story has rescued it. Here's hoping that tomorrow's story will finish the whole thing off with a bang. STATS: Doctor(s): Fourth Companion(s): Romana Episode(s): The Power of Kroll - Parts 3 & 4 Steps Walked: 7,457 today, 1,726,842 total Distance Walked: 4.11 miles today, 868.77 miles total Weight: 253.40 lbs (five day moving average), net change -53.90 lbs < Previous Post Progress is a very flexible word. It can mean just about anything you want it to mean. Next Post Five Hundred Episodes!


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Wed, Jun 28, 2017
Longines celebrated English sartorial elegance at the 2017 Royal Meeting at Ascot, welcoming its Ambassador of Elegance and alpine skiing champion Aksel Lund Svindal to the event.
The Swiss watch brand was the official timekeeper and watch of this prestigious horse racing event, which ran from June 20 to 24.
This year's Royal Ascot was marked by three race records in The Queen Anne Stakes, The Coventry Skates and The St James's Palace Stakes.
On the first day, the owners of Lady Aurelia, the winning horse The King's Stand Stakes, received an elegant Longines watch from The Duke and Duchess of Cambridge.
Longines Vice President and Head of International Marketing Juan-Carlos Capelli presented a watch to Stevie Donohoe, the winning jockey of The Coventry Stakes.
Owner, trainer and lad of Rajasinghe, the winning horse of this race, were rewarded with refined Longines watches as well.
Longines, which celebrated last year the ten-year anniversary of its partnership with Ascot, is the official timekeeper and watch and official partner of Royal Ascot, with the brand having enhanced on course presence including a branded chronometer close to the winning post.
At the event, the Swiss watchmaker also presented new models from the Longines Master Collection, displaying a sunray blue dial. These fashionable chromatic variations are perfectly in line with the classic and understated spirit of this collection and come in several diameters, so that men and women can find the watch best suited to their wrist.
Longines' passion for equestrian sport dates back to 1878, when it produced a chronograph engraved with a jockey and his mount. Seen on the racetracks as early as 1881 and extremely popular among jockeys and horse-lovers, this model enabled its user to time performances to the seconds. In 1912 already the company partnered for the first time with an international show jumping competition. Today Longines' involvement in equestrian sports includes show-jumping, flat racing, driving, dressage and eventing competitions.
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text: Can you identify these two ships? Posted by: Michael L. Grace May 25, 2009 Identify these two ships. There were no captions. One appears to be a coastal night boat and the other a steamer from the 1920s. Crusiing the past – cruise history puzzle! Use Facebook to Comment Comments identify mystery puzzle ships 2009-05-25 Michael L. Grace


text: The NWT Target Centre mobile application is an easy and simple solution for you to use to make, manage and monitor your grain offers for your preferred North West Terminal location. Key Features: - View updating cash bids anytime - Create sales and target offers 24/7 - Monitor updating futures prices when futures markets are trading - Adjust your target prices at any time - View Contracts traded on the DTN Portal Online Offer Center This mobile application is powered by the DTN Portal and will sync with your North West Terminal DTN Portal online account. Call DTN at 1-800-311-1516 with any questions.


text: Post by After Affects Rec (@after-affect-rec) on Mon, 15 May 17 17:12:46 +0000 View Full Post 4th extract from the "Carn Rmx EP" to be released next Wednesday on AFTER AFFECTS REC Name your price EP to help the refugees ! Swarm Intelligence - Carn - Detritus RMX (Original By GROSSO GADGETTO Feat Sir Jean)- Out 17.05.17 PEACE ! https://soundcloud.com/after-affects-rec/syk2ne-carn-rmx


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What is osteomalacia?
Osteomalacia is the softening of bones in the body, leading to bone pain, bone tenderness, bending of the long bones and, at times, even fractures.
Although bone appears to be hard, it is mostly made of collagen, the same material that flexible body parts like skin and tendons are made from. Bones become hard when a mineral, calcium phosphate, coats the collagen fibres in a process called mineralization. The more mineral in the bone, the harder the bone is.[1]
New bone is being formed in the body all the time. If the new collagen fibres are not properly coated with mineral, the bones become soft and may bend and break. This condition is known as osteomalacia.[2]
The most common cause of osteomalacia is a lack of vitamin D. In the United States, incidences of osteomalacia are rare, depending on location. People who live in cooler climates, particularly people with darker skin, are more at risk of developing osteomalacia.
In most cases, the prognosis is good, and the condition can be cured with straightforward treatment, often involving a course of vitamin and/or mineral supplements.
Symptoms of osteomalacia
Soft bones are a typical sign of osteomalacia. It can lead to symptoms such as:[3][4][5]
- Pain or tenderness in the bones
- Muscle spasms and/or cramps
- Muscle weakness, particularly in the thighs and buttocks
- Waddling gait and/or difficulty walking
- Feeling of pins and needles (paresthesia) or numbness around the mouth or in the arms and legs, in cases of calcium deficiency
Very severe cases of osteomalacia may result in:
- Bone deformity, i.e. bending of the long bones
- Pseudofractures, known as Looser's zones, particularly in bones that bear weight such as the feet and pelvis
- Fractures of bones, especially after an event that would not usually cause such severe consequences, e.g. a non-severe fall in a middle-aged person
Osteomalacia is sometimes confused with other conditions which involve signs of weakening of bones, specifically rickets, osteoporosis and osteopenia. See these resources on rickets and osteoporosis for more information.
Causes of osteomalacia
The causes that lead to the development of osteomalacia are most commonly not getting enough vitamin D and/or phosphorus. Although vitamin D deficiency is increasing in some countries, this does not always lead to osteomalacia.[6]
There are rare forms of osteomalacia that are caused by genetic factors or conditions that affect the body's ability to absorb vitamin D or phosphorus, such as liver disease, kidney failure or coeliac disease.[7]
Lack of calcium can also cause osteomalacia, but, in Western countries, it's rare for people to have a calcium deficiency.[7]
Vitamin D deficiency and osteomalacia
Vitamin D is important for healthy bones because it encourages the body to absorb calcium and phosphorus.[8] The body makes vitamin D when ultraviolet (UVB) waves, which are found in sunlight, directly touch the skin, interacting with the body's chemistry to form vitamin D3.[9]
People who live in climates with seasons lacking strong sunshine, such as autumn and fall in the northern hemisphere, or who are unable to get direct sunlight on their skin, will not produce enough vitamin D to create the minerals which harden bones.[10] This increases a person's risk of developing osteomalacia.
See this resource on vitamin D deficiency for more information.
Phosphate deficiency
Less common forms of osteomalacia are caused by conditions that affect the body's ability to absorb phosphates. These include:[11]
- Rare genetic defects
- Kidney disease, though more common in advanced stages, and kidney failure
- Liver disease
Certain drugs
Some medications can increase the risk of osteomalacia when taken for a long time and/or in higher dosages.
Some older epilepsy medications linked to osteomalacia include:[12]
- Sodium valproate
- Carbamazepine
- Phenobarbital
- Topiramate
- Phenytoin
Other medications that are associated with osteomalacia include:[13] - Cholestyramine, used to reduce cholestero - Rifampicin, an antibioti - Isoniazid, used for treating tuberculosi - Antacids containing aluminu - Saccharated ferric oxide, used to treat anemi - Biophosphonates, used to treat osteoporosis and bone metastase - Fluoride, used to prevent tooth decay
Who is at risk of osteomalacia
People who live in cooler climates, where there isn't much sunlight during the autumn or fall, are at risk of developing osteomalacia.[14]
Anyone who covers most of their skin when they go outside, uses very strong sunscreen or can't get outside due to illness or disability, is unlikely to be able to make enough vitamin D from sunlight, even in spring or early summer.[5]
People with dark skin, who live in countries without strong sunlight, are particularly at risk. This is because darker skin does not make as much vitamin D as lighter skin.(^10]
Lactose-intolerant people may not get enough calcium and vitamin D in their diets to produce strong bones, and so may need to consume other foods high in calcium and vitamin D instead.[5]
See this resource on vitamin D for more information.
Diagnosing osteomalacia
Osteomalacia can be diagnosed with a blood test measuring levels of calcium, vitamin D and phosphate in the body.[15] X-rays, CT and MRI scans can detect bone fractures.
Treatment and prevention of osteomalacia
Osteomalacia is treatable, usually with vitamin and/or mineral supplements, and most people can be cured. It is generally treated by administration of vitamin D, calcium and, if needed, also phosphorus.[5]
If the osteomalacia is caused by an underlying condition, this will also need to be treated. Osteomalacia caused by phosphate deficiency is usually due to another condition. Treatment will be recommended by a doctor.[4]
Bone will begin to strengthen within a few weeks to a few months and should be fully healed within six months. However, pain and muscle weakness may continue to be experienced during the healing process.[5][16][17]
Vitamin and mineral supplements
The amount of supplementary vitamin D a person may require depends on factors such as their age, how much natural sunlight they receive where they live and any possible other influencing factors, like having certain medical conditions or taking certain drugs that influence how the body takes up, processes or builds vitamin D.
For people living in the United States, the National Academies of Science, Engineering and Medicine recommends the following daily intakes for adults:[18]
- Vitamin D: 600 IU (international units) / 15 mcg a day
- Calcium: 1,000 mg a day
- Phosphorus: 700 mg a day
For people living in the U.K., the NHS recommends 400 IU / 10 mcg of vitamin D per day for adults. During summer, the NHS advises that most people should be able to make enough vitamin D from sunlight, given enough sun exposure, and diet.
See this resource on vitamin D deficiency for more information.
If a person's calcium intake from diet is less than 750 mg a day, supplements of 500-1,000 mg a day can help speed up the process of restoring bone.[17] Do not take more than 1500 mg of calcium supplements a day without consulting a doctor, as this could lead to unwanted side effects.[19]
Sources of vitamin D in food
Another way of getting vitamin D is through diet, though it does not occur in many foodstuffs. Vitamin D is found in foods such as:
- Oily/fatty fish
- Liver
- Egg yolks
- Cheese
- Foods fortified during the manufacturing process
See this resource on vitamin D for more information.
Maintaining healthy bones
There are many things people can do in day-to-day life to promote healthy bones. These include:[20]
- Having a diet rich in vitamin D
- Getting a healthy amount of sunshine
- Reducing alcohol intake
- Stopping smoking
- Exercising regularly
- Maintaining a healthy weight
Other medications that are associated with osteomalacia include:[13]
- Cholestyramine, used to reduce cholesterol
- Rifampicin, an antibiotic
- Isoniazid, used for treating tuberculosis
- Antacids containing aluminum
- Saccharated ferric oxide, used to treat anemia
- Biophosphonates, used to treat osteoporosis and bone metastases
- Fluoride, used to prevent tooth decay
Osteomalacia FAQs
Q: Are osteomalacia and osteoporosis the same thing?
A: No. Osteomalacia is the softening of bones, usually due to a lack of vitamin D. Osteoporosis is when bones lose density and become brittle, usually because of age or hormone related changes. While the signs and symptoms of both conditions may be similar, the underlying causes and treatments are different.
Q: Are osteomalacia and rickets the same thing?
A: Yes, the only difference is the age of the person with the condition. Osteomalacia in children is called rickets, but its cause, symptoms and treatment are the same. Children with rickets are at a much higher risk of developing skeleton abnormalities because they are still growing.[21]
Q: Are osteomalacia and osteopenia the same thing?
A: No. Osteopenia is similar to osteoporosis in that it is caused by loss of bone density, but isn't severe enough to be classed as osteoporosis.[22]
Q: Can osteomalacia cause osteoporosis?
A: No. Osteoporosis is caused by the bones losing density, usually due to the ageing process and/or hormonal changes in postmenopausal women.
Q: Can osteomalacia be reversed?
A: Yes. Bone is being renewed all the time, and getting enough of the right vitamins and minerals will allow normal mineralization to occur. (See What is osteomalacia?) The process takes around six months. (See Treatment and prevention)
Q: Can osteomalacia be prevented?
A: Yes. Getting enough vitamin D, calcium and phosphorus, adapted to the special needs of someone with liver or kidney disease if necessary, will prevent osteomalacia.
National Institute of Arthritis and Musculoskeletal and Skin Diseases. "What Is Bone?" Accessed April 5, 2018. ↩
Arthritis Research UK. "What is osteomalacia?" Accessed April 5, 2018. ↩
Amboss. "Osteomalacia and rickets, subdivision: clinical features." January 2018. Accessed April 25, 2018. ↩
Hypopara UK. "Osteomalacia." July 2008. Accessed April 5, 2018. ↩ ↩
MedlinePlus. "Osteomalacia." March 2018. Accessed April 5, 2018. ↩ ↩ ↩ ↩ ↩
JAMA Internal Medicine. "Demographic Differences and Trends of Vitamin D Insufficiency in the US Population, 1988-2004." March 2009. Accessed April 5, 2018. ↩
Arthritis UK. "What causes osteomalacia?" Accessed April 5, 2018. ↩ ↩
National Center for Biotechnology Information. "Bone Health and Osteoporosis: A Report of the Surgeon General: The Basics of Bone in Health and Disease." 2004. Accessed April 5, 2018. ↩
National Institutes of Health. "Vitamin D." March 2018. Accessed April 5, 2018. ↩
The Journal of Nutrition. "Vitamin D and African Americans." April 2006. Accessed April 5, 2018. ↩
National Center for Biotechnology Information. "Bone Health and Osteoporosis: A Report of the Surgeon General: Diseases of Bone." 2004. Accessed April 5, 2018. ↩
Epilepsy Action. "Osteoporosis and epilepsy." August 2016. Accessed April 5, 2018. ↩
US National Library of Medicine. "Drug-induced osteomalacia." October 1998. Accessed April 26, 2018. ↩ ↩
Arthritis UK. "Who gets osteomalacia?" Accessed April 5, 2018. ↩
Arthritis UK. "How is osteomalacia diagnosed?" Accessed April 5, 2018. ↩
Patient Info. "Vitamin D Deficiency including Osteomalacia and Rickets." June 2015. Accessed April 5, 2018. ↩
Arthritis UK. "What treatments are there for osteomalacia?" Accessed April 5, 2018. ↩ ↩
The National Academies of Science, Engineering and Medicine. "Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids." August 2000. Accessed April 5, 2018. ↩
NHS Choices. "Calcium." March 2017. Accessed April 26, 2018. ↩
Arthritis UK. "Self-help and daily living for arthritis." Accessed April 26, 2018. ↩
The Royal Children's Hospital Melbourne. "Rickets." January 2014. Accessed April 5, 2018. ↩
MedlinePlus. "Bone Density." March 2015. Accessed April 5, 2018. ↩


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Solid build quality overall, although some of the hardware is a bit lacking. No threadlocker, locking washers or locknuts are supplied so be prepared to have some if you don't want to lose a bolt. The engine has plenty of power, even a 200lb rider pushing the weight limit of this bike has more than enough power to get up quite steep hills. The seat is large and padded well, definitely one of the better seats you'll find on a mini bike. The wheels and tires are much larger than your typical bike, and combined with the built in jack shaft-like gear reduction unit, this bike has heaps of ground clearance.
My biggest complaint would be, as many others have stated, lack of top-end speed. The bike is geared down low to keep the engine unstressed and allow insane hill climbing ability. Other than that, its a super solid bike
One thing to note: I had to return the first one I received due to damage from shipping. Amazon just sends these out in the box they come in, which really has minimal to no padding in certain areas. The box is designed with one way up and should be shipped freight, according to my UPS driver. They just flip and roll these boxes any way during shipping, and the bikes are just not wrapped up for that unfortunately.
The Coleman Trail200U (CT200U) is a nostalgic, reliable, affordable off-road trail mini bike that will take an adult back to their childhood. The Coleman mini bike will provide years of fun on the trail for the entire family. It comes with easy pull start operation, 196cc engine, low pressure tires for a soft and stable ride, rugged and proven clutch, jackshaft, and chain drive along with rear drum – handle operated braking system.
They used UPS to ship it to me and BOTH times I received my bike, it had serious shipping damage. The first time it was so bad I had to return it, and had I not needed this for a birthday present when I did I definitely would have returned the second one as well.
I also have a friend who ordered one who had issues with shipping damage with his as well, so these are not isolated issues. Quite frustrating, definitely causes one to lose faith in ordering larger items from Amazon.


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April 25, 2011: wallet threat level green
You know it's a slow week when the only cause for excitement is a downloadable game from the folks who made Super Stardust and Dead Nation. Outland seems like a mostly typical side-scrolling platformer, but with trippy graphics that recall Out of this World*. It'll be available from Xbox Live on Tuesday and from the Playstation Network whenever Sony gets their act together.
Also out this week are add-ons for Operation Flashpoint and IL-2. And whatever Dark Spore is.
* If you have to ask, you're too young to know.