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Neurodegenerative Diseases pp 331-336 | Cite as
Channel Formation by a Neurotoxic Beta Amyloid Peptide, Aβ25–35
Alzheimer's disease (AD) is a chronic neurodegenerative disorder which is accompanied by memory loss and defects in cognitive function. The features in AD brains include extracellular senile plaques, intracellular neurofibrillary tangles, and amyloid proteins deposited in walls of cerebral and meningeal blood vessels. The major component of these pathognomonic lesions of AD has been identified as a 39–43 amino acid long peptide called beta amyloid peptide (Aβ). Aβ is derived from the amyloid β precursor protein (βAPP)1. The thesis that Aβ deposition plays a central role in the pathogenesis of AD has garnered increasing attention. It has been demonstrated that Aβ either is directly neurotoxic to neurons in culture,2,3 or potentiates neuronal vulnerability to excitatory neurotoxins.4,5 Neurotoxic activity has been reported to be located in the fragment of Aβ, Aβ25–35.2 We hypothesize that Aβ and its fragments, such as Aβ25–35, can form ion channels in neuronal membrane, which may allow calcium entry either directly or indirectly, thus leading to neuronal death and neuropathology of AD. In this study, we will characterize the ionic channels formed by Aβ25–35. Preliminary reports of this work have appeared elsewhere.6,7,8
KeywordsPlanar Lipid Bilayer Single Channel Recording Intracellular Neurofibrillary Tangle Chronic Neurodegenerative Disorder Extracellular Senile Plaque
Unable to display preview. Download preview PDF.
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subset: commoncrawl


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MONTROSE -- Jury selection began Monday in Susquehanna County for a man accused of causing a deadly crash that killed a U.S. Marine.
Arlan Taft from Tioga is charged with homicide by vehicle and involuntary manslaughter.
Prosecutors say Taft was driving a water truck too fast when he crashed into traffic stopped on Route 29 near Springville in January of 2015.
The truck struck the vehicle of Staff Sergeant Andrew Stevens, killing him.
Stevens, who was originally from Springville, is survived by two sons.


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Pro-seminar: The Mathematics of Partisan Gerrymandering
Moon Duchin and Mira Bernstein
Monday, November 13, 2017
12:00 p.m.-1:30 p.m.
10 Stone Ave, Room 201
with Moon Duchin, Department of Mathematics Associate Professor at Tufts University and Mira Bernstein who holds a research faculty position in the interdisciplinary program in Science, Technology, and Society at Tufts University.
about the speakers
Moon Duchin is Associate Professor of Mathematics, Director of STS, and a Senior Fellow in the Jonathan M. Tisch College of Civic Life at Tufts University. Her mathematical research is in geometric topology, geometric group theory, and dynamics. She is working to focus mathematical attention on gerrymandering, with special attention to modernizing the shape analysis of voting districts.
Mira Bernstein is on the research faculty in the Science, Technology, and Society (STS) program at Tufts and is a founding member of the Metric Geometry and Gerrymandering Group. Trained in pure mathematics, she has shifted careers to data science and mathematical education. Her work uses math to solve social problems, from exploring the effects of extending health insurance to low-income populations to combating forced labor throughout the world.


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It's a hat-trick! We are extremely happy to announce that we have won a top award at the prestigious British Travel Awards for a third straight year.
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What does it feel like?
Leukaemia will replace your healthy blood cells with ones that don't work properly. This can mean that you may feel a bit poorly at times and possibly:
- Get lots of coughs and colds
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- Get lots of bruises even when you haven't banged yourself
How is it diagnosed?
A blood test will show any changes in your blood. If the specialist thinks it might be ALL, they will need to take out a little bit of bone marrow to test. This is done using an anaesthetic so it won't hurt.
Will I need medicine and treatment?
AML is treated with a special medicine called chemotherapy that kills the cancer cells. The first step is to get you into remission. Being in remission means that the specialist can't see any leukaemia cells in your blood or bone marrow through a microscope. You will need to stay at hospital a lot during this time, to make sure that you don't pick up any other illnesses.
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Chemotherapy might make you feel more tired and poorly than usual. It can make you feel a bit sick, change how much you need the toilet and you might lose your hair while you're on treatment. This might sound a bit scary, but it is very normal and part of helping you get better.
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When your treatment has finished, you will still need to see a doctor regularly to make sure your cancer is staying away. When the doctor is sure that your cancer has gone away, they will want to make sure that your body continues to work properly after the treatment. Sometimes, people will need to continue having help, but lots of people get better without any problems.
Updated April 2018, next review due 2021.


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Building the Right Environment to Support AI, Machine Learning and Deep Learning
You need to do two things to create an event handler.First, implement a Listener for the type of event you wish to process. Secondly, you must provide a public method that will receive notifications when the events occur.
For example, to handle a button click, you must implement the java.awt.event.ActionListener class and provide a public actionPerformed method. The actionPerformed method takes one parametera java.awt.event.ActionEvent object that contains information about the event, such as the source item that generated it.
To specify that you wish to have an event acted upon, you call the addActionListener method of an objectthe button in the example programpassing as a parameter the class that is will respond to its events. For example, the code in Listing 1 passes this to the addActionListner method example, meaning that this class (Class1) handles actions performed with the Button. In Java, 'this' always refers to the current object. The code shown is equivalent to writing:
btnColor.addActionListener (class1);
You can see that Listing 1 contains all the required elements, the Button, the Listener (see the btnColor.addActionListener method call), and the actionPerformed.
btnColor.addActionListener (class1);
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