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Torrent alison moyet the minutes 2016 и тяга к свободе трек
13.10.14: 292 HD images Strictly Come Dancing week 2. Yes I know week 3 has already happened. I am a bit behind. I'll try and watch week 3 after uploading. For everyone who has problems or doesn't know how to unpack z01, z02, files, follow this simple procedure: install the latest version of winzip or winrar VA - Now That's What I Call The 80s Hits (2016) MP3~320Kbps ~ Hunter 1 0 Alison Moyet - Is This Love 42. Five Star - Can't Wait Another Minute. OVER 11 Million Read The Macca Report!!! The most read, informative Paul McCartney site on the Net! 10,000 new visitors
Welcome to the Official Website of Alison Moyet. Alison reached Top 5 with her eighth studio album, the minutes, and more recently has released Deluxe. Whatsonstage.com/glasgow-theatre/shows/adam-ant-anthems-the-singles-tour_109257/ Adam Ant - Anthems - The Singles. When an AccurateRip program is installed, it will be in an unconfigured state for the reason no accurate rips can take place until the offset This is the absolute ULTIMATE experience of Queen's set at LIVE AID, this is the best video mixed to the absolutely superior stereo radio broadcast. Find London shows and buy theatre tickets for musicals, plays, operas and more - on the West End, Off-West End and around London.
A new double album documenting Tracey's solo career outside of Everything But The Girl and the Marine Girls is released on October 23 2015 by Caroline International. Tr.im has blocked access to this link because of dangerous and unsafe content. For everyone who has problems or doesn t know how to unpack z01, z02, files, follow this simple procedure: install the latest version of winzip or winrar 13.10.14: 292 HD images Strictly Come Dancing week 2. Yes I know week 3 has already happened. I am a bit behind. I ll try and watch week 3 after uploading.
1,892 Cover Songs Men Could Listen To A few months back, Tom Junod wrote an appreciation of the artful cover song. A few weeks later, reader John James wrote September 30, 2016 by Paul Sinclairtags: 1980s, 1990s, Alison Moyet Alison Moyet's 1984 album Alf will be reissue as a two-CD deluxe edition in November along Bruce Springsteen offers fans free download of River Tour concert The Factory Mix from the CD is over 9 minutes so maybe that is why it was omitted. The Minutes (stylised as the minutes) is the eighth studio album by English singer -songwriter Alison Moyet, released on 3 May 2013 by Cooking Vinyl. Aside from offering a free download of the track "Changeling" via her official web site, Moyet began release This page was last modified on 11 April 2016, at 08:35.
ROCK POP DVDs A B C D E F G H I J K L M N P Q R S T U V W NEW ADDITIONS AEROSMITH - Monsters Of Rock Festival 2013 BLONDIE - Isle Of Wight Festival. Playbacks playback midi midis musicas karaoke compra venda troca play back play backs. Tickets for Alison Moyet's The Other Tour go onsale worlwide on Friday 24th March. Click on the BUY links. UNITED STATES /CANADA 11 Sept – Sixth and I: Washington. The Tr.im team has removed this link for your safety. We (Tr.im team) work to make sure all our stakeholders adhere to our terms and conditions and our general safety. List of all Alison Moyet albums including EPs and some singles - a discography of Alison 8 The Minutes is listed (or ranked) 8 on the list Alison Moyet Albums. Listen to songs and albums by Alison Moyet, including "The Minutes," "Alf," "The Turn," and many more. Songs by Alison Moyet start at .29. Free with Apple. Cartolina dalla vacanza Design by Gio Vi Mitopositano com - News Manciano - Saturnia - indexvecchia - index cogn - Hotels of the world - Agriturismi Vacanze. Complete your Alison Moyet record collection. Discover Alison Moyet's full discography. Shop new and used Vinyl


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Use your fear
What is fear?
False evidence appearing real? Or, fuck everything and everything run?READ MORE
What is fear?
False evidence appearing real? Or, fuck everything and everything run?READ MORE
People that just make themselves busy for no real point other than just being busy.READ MORE
Fasting completely changed my relationship with what health meant but also it changed my relationship with what symptoms meant. I learnt about what's called the healing crisis.READ MORE
I don't like the term mental illness. I prefer the term mental advantage because a lot of these labels are just certain characteristics and behaviours.READ MORE
Whatever you need in life will control you. We're all addicted to something. The question is, is it external or is it internal?READ MORE
You might think that money is really important to you but you've got to completely remove that from your psychology.READ MORE
Right now, the only thing standing between you and your mission, is you being able to see the most direct route to get there.READ MORE
Sales is about communication and relationships. It is about service. So many people see sales as a process of selling something to someone regardless of whether or not they need it or not.READ MORE
A higher level of comfort around people expressing themselves about who they really are, not who they think they have to be to make someone happy that they don't even know.READ MORE
Self-sabotage is an unconscious mechanism that your psychology uses to prevent rejection from your herd.READ MORE

subset: commoncrawl


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|Marlin Financial
|Marllyn S. Justice Cpa PA
|Vero Beach FL,
|Marmaras Woolf and Smith
|Allentown PA,
|Marnie B. Aznar Dba Aznar Financial Advisors LLC
|Marotta Asset Management Inc.
|Charlottesville VA,
|Marque Millennium Capital Management LLC
|New York NY,
|Marquette Asset Management
|Minneapolis MN,
|Marquette Associates Inc.
|Chicago IL,
|Marret Asset Management Inc
|Toronto Ontario
|Marriott Affiliated Capital Partners LLC
|Lehi UT,
|Mars National Advisors L.L.C.
|Mars PA,
|Marshall & Sullivan Inc.
|Seattle WA,
|Marshall Capital Management Group
|Louisville KY,
|Marshall Chawla & Associates
|Falls Church VA,
|Marshall Plan Advisors Inc.
|Marshall Point Advisors LLC
|Marshall Wace Llp
|Marshall Wace North America L.P.
|Greenwich CT,
|Marshall Wealth Management Group Inc.
|Salinas CA,
|Marshalla Asset Management
|Los Altos CA,
|Marshfield Associates
|Washington DC,
|Marsico Capital Management LLC
|Denver CO,
|Martel Dorow Inc.
|Portsmouth NH,
|Martin Glen J.
|Martin Wardin & Eissner Financial Group Inc.
|Pleasanton CA,
Latest Advisers
Approved Financial Advisers
|Avonda Wealth Management of Raymond James
|Stuart FL,
|Bogota O,
|Liberty Financial Strategies
|IMG Wealth Management, Inc
|Jacksonville FL,
|Selkirk Wealth Advisors, LLC
|Spokane WA,
|Fi Protect Ltd
|Milton Keynes O,
|Wadiah capital SA
|toronto ON,
|Amman O,
|Compass Asset Management Group
|Newburgh NY,
|Insight Wealth Strategies
|San Ramon CA,
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text:
A quick preview of 'In Presence Of The Moon Nobody Sees Stars" the book I'm working on those days.
I really can't wait to print this book and I can't thanks enough the NASA.
I wish you a every nice day. 🚀
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I attended the In-Cumbria Digital Breakfast event at the Business Interaction Centre in Carlisle city centre yesterday morning, on Thursday 27 March.
The event was well attended by businesses and had several guest speakers ranging from small business owners to official representatives from BT.
It was great to hear from speakers who have embraced advances in social media technologies such as Twitter, Facebook and LinkedIn to create additional revenue streams for their businesses. One recent start-up company described how after they had investigated the SEO (Search Engine Optimisation) facility and put this into practice, they moved from page seven Google results to page one, transforming their online trading.
BT updated delegates on the current roll out of super-fast broadband throughout the UK. 46% of the UK are now able to receive super-fast internet access, including 28,400 actual premises in Carlisle. It's fantastic to see this service now reaching our area, having a positive day to day impact on individuals and businesses.
To find out if you or your business can receive super-fast internet access please visit www.connectingcumbria.org.uk/home
Darren Crossley, Deputy Chief Executive of Carlisle City Council described plans to cover all of the city centre high street with free internet access. They are moving into the final planning stages and if approved the project would be completed by Autumn 2014.
At David Allen IT Solutions News we pride ourselves in keeping up to date with the latest technological news and advances and ensure we remain at the forefront of developments in our area. To understand how we can help you and your business please contact one of our team on 01228 711888.
Neil Kendall
Posted: March 28th, 2014


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Folsom Restaurants
Do you want to advertise your restaurant for free in the town of Folsom?
Folsom, CA has one of the widest choices of restaurants, of an area its size, in the whole of the USA. Just about 50% of the restaurants in Folsom are full-service restaurants with 75% of the others offering limited help. The extra restaurants inFolsom are mostly drinking places and caterers that recommend some in-house foodstuff.
Full-service restaurants in Folsom tend to offer several menu sorts, plus appetizers, salads, side dishes, desserts, and more drinks, with quite a few choices within each kind. Chefs and cooks will get ready the items to buy, starting from grilling a hamburger to arrange a further complicated and chic menu item. Waiters and waitresses offer table service in comfy surroundings. Consumers increasingly be partial to dining at mid-scale or family restaurants, typically run by a national chain. By contrast, patrons at the improved on Folsom dining places be inclined to seek a nice environment with adroitly arranged gastronomy and relaxed, specialist service. While groups are a significant slice of the restaurant market, many patrons in Folsom favor dining in non-franchised owned as well as locally operated restaurants.
The most regular type of a limited-service restaurant in Folsom, CA is a franchised firm of an all over the country restaurant franchise selling fast food. Like elsewhere, these restaurants in Folsom includes a set menu, the lack of waitresses and waiters and an emphasis on cleanliness and an efficient service. Menu choices will offer restricted range and are made ready by workers with minimal cooking or food-management skills. Foodstuff typically is served in disposable take-out cartons that keep hold of the food's warmth, allowing restaurants to make orders in advance of customers' requirements. A mounting number of fast-food restaurants in Folsom, CA are now providing drive-through and walk-up services.
Restaurants are the most rife and time-honored trade in the United States. The greatest restaurants, especially the best restaurants in Folsom, CA present
- Freshly prepared food focused on community favourites
- Menu choices with the intention of suiting everyone in the family unit
- Capable and motivated workers that smile!
- Cleanliness
- Every single one of the list above at an inexpensive value!
Individuals of Folsom are acknowledged for liking restaurants that offer something that alternative establishments do not have and they like restaurants where the workforce working there genuinely like what they are doing.
The public Folsom are looking for restaurants with the intention of making you feel great subsequent to eating there.
The clients attracted to establishments in Folsom change according to many factors, including the style of food presented, prices, position and the marketplace the restaurant is aimed at.
To attract customers in Folsom, CA you be obliged to focus on
- High-earning persons or families with a significant amount of disposable salary but little moment in which to splurge it. This patron collection includes the mounting number of single householders, as well as dual-takings household groups.
- Business people on cost accounts to boost lunchtime business plus evening meals. The importance of this market often tends to track the wider fluctuations in native companies.
- Tourists are key for a lot of restaurants in the neighborhood. At all times remember that visitor numbers to Folsom oscillate according to the seasons, and winter, specifically, possibly will see poorer trading.
- Family. The influence of family has formed a major market grouping that impacts on family choice for meals. This has been cheerfully picked up on by the large conglomerates who, led by the burger franchises, target family through their marketing.
- Working women. Married women undertake more than sixty percent of all household responsibilities, subsequently easy access to meals is welcomed as one fewer task to undertake. Price tends to be a substantial issue affecting the preference of this collection, next to the class of the food.
- Grazers. As lifestyles have changed, the usual three meals per day have been replaced by a propensity to graze or eat on the hoof. Convenience plays a substantial amount in this group's choice of venue.
- The emergence of a large group of retired inhabitants with a high level of disposable income and improved leisure time. Study indicates that this troop tends to eat out during the daylight hours as a leisure interest.
If you are opening a restaurant in Folsom, CA you should
- Make out the most excellent locality in order to attract passing business. If you are planning to rely by word of mouth and make your business over a very extended period, position will play a vital component in the eventual triumph of your dealings.
- Settle down into your working routine (and make sure your employees are familiar with their occupations!) and then summon reviewers from the Folsom media to carry out a restaurant evaluation - a good appraisal is likely to boost resident interest in your organization.
- Make it a certainty you are listed in regional food and restaurant handbooks. This will necessitate signing on with the Folsom holiday guides and this will also appeal to citizens from outside of the direct quarter.
- Spread around in newspapers read by your intended addressees. Folsomnewspapers and business magazines usually tender reasonably priced advertising space.
- Stand out from your competitors by selecting an special icon or theme and applying it to your decoration, personnel uniforms, crockery and cutlery, and menus.
- Promote distinct audiences depending on the time of the day or season of the year. Mutually daytime and evening menus may possibly be provided, with everyday specials offered to alter the usual bill of fare.
- Use exclusive offers to boost trade throughout loose times, with mid-afternoon discounts for pupils and elderly diners, and special kid's menus offered to catch the attention of families. Christmas is a crucial spell for most restaurants, because it offers the opportunity to intensify trade owing to corporate parties and can be an initiation to your restaurant for would-be new clients who can revisit right through the rest of the year.
As word-of-mouth exposure is of the utmost importance for Folsom restaurants, it is crucial that your client service should always be attentive, on time and well-mannered!
Folsom Restaurant Newsletter
Free information on restaurants in the USA - where to eat, vouchers off, menus as well as information on setting up and running your own restaurant. Sign up to our newsletter now.


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Tech firm readies for rollout of online med-monitoring system
CRYSTAL LAKE, Ill. An online technology and communications firm says it is ready to take a new alert and communications system for medication adherence to the next level by testing its widespread application among everyday users.
The system, called eMedonline and developed by Leap of Faith Technologies, relies on cell phone technology and barcode scanning technology to help patients remain safe and compliant with their medication therapy. The system—which can also be harnessed for clinical trials and other uses—includes a wireless device for use in a patient's home, along with Web-based services that collect and distribute information between the patient and clinician, according to the company.
"eMedonline can be thought of as a 'smart service' that leverages the inherent abilities of wireless technologies like cell phones and radiofrequency identification to facilitate medication compliance and remote patient monitoring," noted Leap of Faith in a report on the product. "It functions as a system that includes a cell phone, RFID, and Web-based services that collect and distribute information between the patient and clinician.
The system works via smartphone technology and either barcode scanning or RFID technology to track and record the medication package. The eMedonline system automatically collects and transmits specific data for individual patients—including dosing times, missed doses, and outcomes data—in real time from a single device. "Medication data read from an RFID tag is collected in real time and helps patients verify that they are taking the correct medicine at the correct time, while helping caregivers and clinicians appropriately intervene in the case of missed medications or adverse events before they become a significant health risk," Leap of Faith stated.
"The data can be analyzed through the eMedonline clinical interface, or exported for use in other clinical monitoring systems," noted the company. "It provides important information on the medication and health status of an individual patient, and on the patient population as a whole."
FDA announces safety review of two immunosuppressive drugs
WASHINGTON The Food and Drug Administration issued an early communication today stating that an ongoing safety review is taking place about the immunosuppressive medications CellCept by Roche and Myfortic by Novartis.
The drugs have been linked in safety data provided by Roche to progressive multifocal leukoencephalopathy, a sometimes fatal disorder that affects the central nervous system.
Roche has recommended including this information in the CellCept label. The active ingredient in CellCept, mycophenolate mofetil, is metabolized by the body to MPA (mycophenolic acid), the active drug ingredient in Myfortic.
The FDA anticipates taking two months to complete its review of the safety data and the proposed revised labeling for CellCept and Myfortic that includes information about PML.
MyInsuranceExpert.com launches in nine states
BLOOMFIELD HILLS, Mich. A new Web site called MyInsuranceExpert.com helps individuals and families research and purchase insurance policies, according to published reports.
MyInsuranceExpert.com is available in Michigan and eight other states and hopes to expand to 40 states by the end of 2009. So far, he said the site's biggest business comes from states like Texas and Florida, where there are fewer companies offering insurance to employees.
People go to the site to receive online quotes and ultimately purchase their insurance policy. But the site also has personal, licensed advisers who work with each client to ensure they have the most cost-effective policy possible.


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Context of Additional Image Of Astracast Korona 1.5 Bowl Composite ROK Granite Inset Sink .
Imageim•age (im′ij),USA pronunciation n., v., -aged, -ag•ing.
- a physical likeness or representation of a person, animal, or thing, photographed, painted, sculptured, or otherwise made visible.
- an optical counterpart or appearance of an object, as is produced by reflection from a mirror, refraction by a lens, or the passage of luminous rays through a small aperture and their reception on a surface.
- a mental representation;
- a mental representation of something previously perceived, in the absence of the original stimulus.
- form;
semblance: We are all created in God's image.
- counterpart;
copy: That child is the image of his mother.
- a symbol;
- the general or public perception of a company, public figure, etc., esp. as achieved by careful calculation aimed at creating widespread goodwill.
- a type;
embodiment: Red-faced and angry, he was the image of frustration.
- a description of something in speech or writing: Keats created some of the most beautiful images in the language.
- a figure of speech, esp. a metaphor or a simile.
- an idol or representation of a deity: They knelt down before graven images.
- the point or set of points in the range corresponding to a designated point in the domain of a given function.
- [Archaic.]an illusion or apparition.
im′age•a•ble, adj.
- to picture or represent in the mind;
- to make an image of;
portray in sculpture, painting, etc.
- to project (photographs, film, etc.) on a surface: Familiar scenes were imaged on the screen.
- to reflect the likeness of;
- to set forth in speech or writing;
- to symbolize;
- to resemble.
- [Informal.]to create an image for (a company, public figure, etc.): The candidate had to be imaged before being put on the campaign trail.
- to transform (data) into an exact replica in a different form, as changing digital data to pixels for display on a CRT or representing a medical scan of a body part in digital form.
im′ag•er, n.
Ofof1 (uv, ov; unstressed əv or, esp. before consonants, ə),USA pronunciation prep.
- (used to indicate distance or direction from, separation, deprivation, etc.): within a mile of the church; south of Omaha; to be robbed of one's money.
- (used to indicate derivation, origin, or source): a man of good family; the plays of Shakespeare; a piece of cake.
- (used to indicate cause, motive, occasion, or reason): to die of hunger.
- (used to indicate material, component parts, substance, or contents): a dress of silk; a book of poems; a package of cheese.
- (used to indicate apposition or identity): Is that idiot of a salesman calling again?
- (used to indicate specific identity or a particular item within a category): the city of Chicago; thoughts of love.
- (used to indicate possession, connection, or association): the king of France; the property of the church.
- (used to indicate inclusion in a number, class, or whole): one of us.
- (used to indicate the objective relation, the object of the action noted by the preceding noun or the application of a verb or adjective): the ringing of bells; He writes her of home; I'm tired of working.
- (used to indicate reference or respect): There is talk of peace.
- (used to indicate qualities or attributes): an ambassador of remarkable tact.
- (used to indicate a specified time): They arrived of an evening.
- [Chiefly Northern U.S.]before the hour of;
until: twenty minutes of five.
- on the part of: It was very mean of you to laugh at me.
- in respect to: fleet of foot.
- set aside for or devoted to: a minute of prayer.
- [Archaic.]by: consumed of worms.
Koronako•ro•na (kôr′ə nə, kōr′- for 1; kôr′ə nä′ for 2),USA pronunciation n.
- Also, krone. a former silver coin and monetary unit of Austria, equal to 100 hellers: discontinued after 1923.
- koruna.
Bowlbowl1 (bōl),USA pronunciation n.
- a rather deep, round dish or basin, used chiefly for holding liquids, food, etc.
- the contents of a bowl: a bowl of tomato soup.
- a rounded, cuplike, hollow part: the bowl of a pipe.
- a large drinking cup.
- festive drinking;
- any bowl-shaped depression or formation.
- an edifice with tiers of seats forming sides like those of a bowl, having the arena at the bottom;
- Also called bowl game. a football game played after the regular season by teams selected by the sponsors of the game, usually as representing the best from a region of the country: the Rose Bowl.
- [Typography.]a curved or semicircular line of a character, as of a, d, b, etc.
bowl′like′, adj.
- to give (a floor) a gentle inclination on all sides toward some area, as a stage or platform.
Granitegran•ite (gran′it),USA pronunciation n.
- a coarse-grained igneous rock composed chiefly of orthoclase and albite feldspars and of quartz, usually with lesser amounts of one or more other minerals, as mica, hornblende, or augite.
- anything compared to this rock in great hardness, firmness, or durability.
Sinksink (singk),USA pronunciation v., sank or, often, sunk;
sunk or sunk•en;
- to displace part of the volume of a supporting substance or object and become totally or partially submerged or enveloped;
fall or descend into or below the surface or to the bottom (often fol. by in or into): The battleship sank within two hours. His foot sank in the mud. Her head sinks into the pillows.
- to fall, drop, or descend gradually to a lower level: The river sank two feet during the dry spell.
- to settle or fall gradually, as a heavy structure: The tower is slowly sinking.
- to fall or collapse slowly from weakness, fatigue, distress, etc.: He gasped and sank to his knees.
- to slope downward;
dip: The field sinks toward the highway.
- to go down toward or below the horizon: the sun sinks in the west.
- to penetrate, permeate, or seep (usually fol. by in or into): Wipe the oil off before it sinks into the wood.
- to become engulfed or absorbed in or gradually to enter a state (usually fol. by in or into): to sink into slumber.
- to be or become deeply absorbed or involved in a mood or mental state (usually fol. by in or into): sunk in thought. She sank into despair.
- to pass or fall into some lower state, as of fortune, estimation, etc.;
degenerate: to sink into poverty.
- to decline or deteriorate in quality or worth.
- to fail in physical strength or health.
- to decrease in amount, extent, intensity, etc.: The temperature sank to 30° at noon.
- to become lower in volume, tone, or pitch: Her voice sank to a whisper.
- to enter or permeate the mind;
become known or understood (usually fol. by in or into): He said it four times before the words really sank in.
- to become concave;
become hollow, as the cheeks.
- to drop or fall gradually into a lower position: He sank down on the bench.
- to cause to become submerged or enveloped;
force into or below the surface;
cause to plunge in or down: The submarine sank the battleship. He sank his fist into the pillow.
- to cause to fall, drop, or descend gradually.
- to cause to penetrate: to sink an ax into a tree trunk.
- to lower or depress the level of: They sank the roadway by five feet.
- to bury, plant, or lay (a pipe, conduit, etc.) into or as if into the ground.
- to dig, bore, or excavate (a hole, shaft, well, etc.).
- to bring to a worse or lower state or status.
- to bring to utter ruin or collapse: Drinking and gambling sank him completely.
- to reduce in amount, extent, intensity, etc.
- to lower in volume, tone, or pitch.
- to suppress;
- to invest in the hope of making a profit or gaining some other return: He sank all his efforts into the business.
- to lose (money) in an unfortunate investment, enterprise, etc.
- to throw, shoot, hit, or propel (a ball) so that it goes through or into the basket, hole, pocket, etc.: She sank the 10 ball into the side pocket.
- to execute (a stroke or throw) so that the ball goes through or into the basket, hole, pocket, etc.: to sink a putt; to sink a free throw.
- sink one's teeth into:
- to bite deeply or vigorously.
- to do or enter into with great enthusiasm, concentration, conviction, etc.: to sink my teeth into solving the problem.
sink′a•ble, adj.
- a basin or receptacle, as in a kitchen or laundry, usually connected with a water supply and drainage system, for washing dishes, clothing, etc.
- a low-lying, poorly drained area where waters collect and sink into the ground or evaporate.
- sinkhole (def. 2).
- a place of vice or corruption.
- a drain or sewer.
- a device or place for disposing of energy within a system, as a power-consuming device in an electrical circuit or a condenser in a steam engine.
- any pond or pit for sewage or waste, as a cesspool or a pool for industrial wastes.
- any natural process by which contaminants are removed from the atmosphere.
sink′like′, adj.
Make or the areas were used-to make that feeling of the kitchen, food. Because the Additional Image Of Astracast Korona 1.5 Bowl Composite ROK Granite Inset Sink . ( Astracast Korona Sink #2) is a place to prepare and set anything carelessly because of the effects of the run of cooking were burned and so on, so that it can be explained the kitchen is one-room that's typically messy and filthy.
So it is today a great deal of kitchens which may have an interesting type with a range of furniture for cooking equipment over a frequent base so as or keeping things not to falter. Perhaps for a lot of the simplest way to prepare the cooking equipment within the home is always to add hook or a hanger to keep some cooking tools that may be put.
Design your kitchen right into a minimalist kitchen, utilize your creative side to design a minimalist kitchen in your house, because the minimalist kitchen is a kitchen that's designed with a kitchen collection along with a large amount of kitchen cabinets that you can employ to place a cooking products. So that for a minimalist home is full, you no longer need to develop a hook or hook in your kitchen.
Surely you'll experience cozy cooking in case your Additional Image Of Astracast Korona 1.5 Bowl Composite ROK Granite Inset Sink . ( Astracast Korona Sink #2) appears clean and clean. Using a comfy home, cooking is more fun, along with the consequence would be the maximum that the recipes may taste better, since the preference of food depends upon the disposition of individuals that are preparing.
Design your kitchen with wonderful, your temper will also be always good and the cook turned cool. Below we attach some test photographs kitchen having a model that is minimalist, using a home such as this within the home you'll generally untouched.
We've a whole lot around the design of the Astracast Korona Sink together with techniques to improve our kitchen's quality. This time we'll offer you ideas to create your home more beautiful with tiled surfaces. Your kitchen is usually based inside and away from the access, but there is also a kitchen that is quickly visible from the living place.
Consequently, your kitchen additionally requires care to create it more exciting. Also, you will definitely feel better having a great kitchen. Therefore home design with ceramic's listing that makes it attractive and beautiful. Wall will come in various designs habits, styles, supplies and even the manifold's installation. You can even use a ceramic wall dining room, bedroom or bathroom.


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Technology education supports, and interventions note-taking learning strategies, supports, and interventions. Note-taking (sometimes written outliners for more about application software that supports especially at institutes of technology online note-taking has. These digital alternatives to pen and paper give you information-retaining benefits of handwritten notes with the organization and convenience of digital note taking. Despite arguments to the contrary, computers can be effective for note taking—if we adequately support students in using them. Personal technology 3 note-taking gadgets keep you scribbling adonit believes it can make note taking more attractive on a tablet by improving the.
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Telogen – Also known as the resting phase. The follicle remains dormant and the hair will be anchored in place. Depending on the strength of the follicle, it will eventually soften and the hair will eventually break free and shed.
Hey guys, thanks for the fantastic tips in this article! I didn't know prior to the benefits of coconut oil on hair as I found it very sticky and hard to style my hair. It was my mother who would regularly apply this on weekends I guess it was an indian practice but I'm glad that she did and now I know the benefits. I can grow 1-1.5 inches per month. I'm a vegetarian and work-out regularly so this adds on top of all this. I can safely say this DOES WORK and your eating style plays a key role in this. Thanks for sharing these tips!
Testosterone replacement is becoming popular for men. Cotsarelis warns that this may accelerate hair loss. Propecia might help — but because it prevents testosterone breakdown, it might affect the dose of male hormone replacement therapy. Cotsarelis warns men taking both Propecia and testosterone replacement to make sure their doctor carefully monitors their testosterone levels.
Make a mixture of one mashed avocado, one mashed banana and one tablespoon of olive oil. Massage it on your scalp and leave the mixture on your hair for about 30 minutes so that the nutrients are absorbed by the scalp. Finally, rinse it out and shampoo your hair.
Usually, you can easily decipher density by simply looking in the mirror. If you can see traces of your scalp when your hair is in its natural state, it's highly likely that you have low density. As for thickness, if you take a single strand between your fingers and feel absolutely nothing, chances are your strands are fine.
Hi Thahani. We've actually never heard of this method before, so can't speak from personal experience. However it looks like fenugreek seeds would be super nourishing for your hair, so you could give it a go. It definitely won't do your hair any harm! 🙂
Thanks for the comments! Happy to hear you like the blog post. Coconut oil is fantastic, I love it for many uses. Make sure you check out my article on the other uses – https://experthometips.com/21-clever-uses-for-coconut-oil-that-may-surprise-you
About the inversion method, why can you only do it for a week? I am looking to grow my hair out and am wondering if you can do it for several weeks for more length. Also, does this method generally seem to work with growing brand new hairs, or just current hairs?
Massaging your scalp regularly with cold-pressed castor oil is one of the easiest ways to get thicker hair naturally. Due to its high viscosity, it coats the hair thoroughly and protects against hair fall. This oil has high amounts of vitamin E and fatty acids, that promote hair growth.
Hair grows everywhere on the human skin except on the palms of our hands and the soles of our feet, but many hairs are so fine they're virtually invisible. Hair is made up of a protein called keratin that is produced in hair follicles in the outer layer of skin. As follicles produce new hair cells, old cells are being pushed out through the surface of the skin at the rate of about six inches a year. The hair you can see is actually a string of dead keratin cells. The average adult head has about 100,000 to 150,000 hairs and loses up to 100 of them a day; finding a few stray hairs on your hairbrush is not necessarily cause for alarm.
Try the Tangle Teezer once and you'll never use a comb again. Short, flexible bristles have give to them so they won't pull out fragile hairs, says hairstylist Mia Santiago of Sharon Dorram Color at Sally Hershberger. You can even detangle wet hair: "If I used a paddle brush on my wet hair, I could make a voodoo doll of the hair that comes out," she says.
Hi Maddie. First off, a big well done to you for donating – how brave and thoughtful of you. Secondly, I think shoulder length hair can be beautiful, so don't worry about looking nice in those wedding pictures. I would recommend the inversion method, 100%. The coconut oil is mainly for hair repair and strength, so if you're struggling for time, I'd opt to increase growth-rate through stimulation of the scalp. Let us know how you get on! 🙂
Why is this pattern of hair loss only in the front and on top? That's where hormone-sensitive follicles live. The follicles on the sides and back of the head aren't affected by DHT and usually stay healthy.
Thanx alot for all the great information.It's alalways nice to know there's hope to better yourself with cheap home remedies rather than spending money you can't afford at the stores. So thank-you.:-)
When you want to thicken hair, there are also a couple of supplements that will help. Cod liver oil (I get mine from Oceans 3) is highly recommended because it's chock-full of omega-3's, including EPA and DHA, that help thicken your hair, improve your skin and even naturally balance hormones. The deficiency of EPA and DHA in diet contributes to skin conditions such as dandruff, thinning hair, eczema and psoriasis, as well as age spots and sun spots. Simply put, without the essential fatty acids, too much moisture leaves the skin.
Most of us, when we think of hair loss, think about aging men. Nearly all men eventually get that receding M-shaped hairline and thinning hair on the top of the head, also known as male pattern baldness. It's called androgenetic alopecia, and it's caused by a by-product of testosterone called DHT.
I know this is not really part of the article, but if my hair has lots of split ends that reaches to my scalp, do I have no choice but to chop it off? My hair is at shoulder length and it has been like that for 2 years and it's the same length. My hair is not that fried but it's pretty damaged. I did the unthinkable and I chopped off the side hairs underneath to let them grow healthy and fresh again. It kinda looks stupid now but will this help me of getting the short hairs long again? Any tips?
After six months of treatment, both groups experienced a significant increase in hair count. Scalp itching, however, was more frequent in the minoxidil group. The study proves that rosemary oil is just as effective as hair growth medications, with less side effects, such as scalp itching. (12)
Remember – 'Inversion' is when your heart is positioned higher than your head. Inversion poses and twists are commonly found in yoga practises and are safe to perform, but if you feel dizzy or light-headed stop immediately.
For thicker hair, I recommend using a thermal protectant or primer like Bumble and bumble Hairdressers Invisible Oil Primer to help smooth out the cuticle surface. This will add moisture and all the styling products to coat the outside of the hair shaft to allow for a better blow dry.
Is it safe to use baking soda on hair? Increasingly, people are using baking soda to clean their hair. However, this is not always safe. Learn about risks and other natural hair remedies here. Read now
A 2011 study published in the British Journal of Dermatology examined the ability of a leave-on combination including panthenol, the alcohol analog of pantothenic acid, to affect the diameter and behavior of individual terminal scalp hair fibers. The treatment significantly increased the diameter of individual, existing terminal scalp fibers. It also thickened hair fibers and increased the pliability, giving the hairs better ability to withstand force without breaking. (4)
– Eat a healthy diet high in protein and iron , chick peas are great for hair health because your getting enough iron & protein that you need . You can also include other healthy foods like meat , chicken , Salmon , dairy products , fruit and vegetables and supplements like biotin which is great for keeping the hair strong and healthy , if none of these options work go to the doctor and have some blood test done to see what is causing it , overall I hope these options work for you .
At any one time, about 90% of the hair on a person's scalp is growing. Each follicle has its own life cycle that can be influenced by age, disease, and a wide variety of other factors. This life cycle is divided into three phases:
Orange juice is also a really great way to promote thicker hair and smells super refreshing. It promotes hair growth, thickens hair, and is great for treating dandruff. To use an orange to help you with your need for thicker hair, take a sliced orange, peel and all, and put it in a food processor until you have a fine pulp. This pulp should be applied to your hair and left on for twenty minutes. Doing so once a week will lead to fuller, thicker hair in a matter of months.


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8070 S Breezy Pine Road Mayer, AZ 86333
Hi, Winona Nuttall.
My name is
and I have a question about 8070 S Breezy Pine Road Mayer
You can respond by either emailing me at
or call during
My Question Is:
Estimated Monthly Payment$5,051
- Photos
- Location
- Questions
- Share
- Mortgage Calculator
- Status: Active
Listing courtesy of HIGH COUNTRY REALTY LLC
Wonderful getaway cabin in the little community of Breezy Pine Acres. Remodeled kitchen. Spacious family room with wood-burning fireplace. Central heat. Enclosed porch is a great place to relax and enjoy the forest views. Detached building could be a hobby studio, greenhouse or storage shed. Lots of fruit trees--cherry, plum, peach and 4 apple trees that produce some of the most delicious apples you've ever tasted! Big Bug Creek is just across the road. Private well w/1100 gallon storage tank in addition to Breezy Pine community water. During the summer, you get the shade from the mountain in the afternoon. During the winter, you have the advantage of being on the sunny side for extra warmth and faster melting of the snow. Immaculate condition! Property corners are flagged., Directions Hwy 69 to West on Poland Rd for apx 9 mi to sign on Right (red mailbox). Property can also be accessed via Big Bug Mesa Road. Call for directions.
Interior Features Include:
Intercom, Wash/Dry Connection, Utility Sink, Kit/Din Combo, Fireplace-Woodburn, Counters-Solid Srfc, Skylight(s), Ceiling Fan(s)
Rooms Family Room, Laundry Room, Hobby/Studio, Game/Rec Room
Window Cov: Draperies, Single Pane
Heating: Forced - Electric
Floor Type: Carpet, Tile
Found - Slab
Exterior Features Include:
Landscaping-Front, Driveway-Concrete, Native Species, Well/Pump House, Shed, Satellite Dish, Permanent BBQ, Patio - Covered, Storm Gutters, Sprinkler/Drip
Outbuildings 2
Acreage: 0.9000 Acres
Topography Level, Other Trees, Ponderosa Pine, Valley, Hillside, Sloped - Steep, Sloped - Gentle
View Lake/Creek/River, Ponderosa Pine, Bradshaw Mountain, Mountains
Roof: Composition
Garage/Parking: Y
Garage Capacity: 2
Other Features Include:
Subdivision: Breezy Pine Acres
Information provided by Prescott Area Association of Realtors and is deemed reliable, but is not guaranteed accurate.


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Thinking as a Hobby
3477367 Curiosities served
Support for Space Exploration
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According to a recent poll, American public support for our space program remains high:
Now of course I support space exploration, manned and unmanned, and I also support the increasing privatization of space flight. It's good to see continued widespread public support, even in a lagging economy.
It's interesting, because at the last workshop in Austin I went to, a well-known writer, in a critique of my story, said that parallels to NASA were "unfortunate". He said going to the moon wasn't about curiosity or exploration, it was about winning a war, building better rockets for missiles, and ego. He said that if you're curious, you don't send people, you send machines, and that the whole rationale for the space program was built on a juvenile lie.
So if we take this as true (which I don't...I'm still apparently naive enough to believe there has always been something of a pioneering spirit in the men and women on the ground and in the ships), why the continued support for the space program now? Is the support supposedly for some indirect boost to our military power? Or is this the real reason, and the government is just doing a great job with propaganda?
Well, this guy apparently bought it:
And I guess that makes me a chump, because I've bought it too.
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Talking about Facebook's Cambridge Analytica crisis with Texas Standard
Posted March 23rd, 2018
This week on the "Texas Standard" radio program, our tech topic was the crisis at Facebook over data from millions of Facebook users apparently used by a company to aid the Donald Trump presidential campaign in 2016.
This week, CEO Mark Zuckerberg spoke out on the matter after a lengthy silence and we discussed what Facebook says it's doing now to address the situation.
You can check out the segment on the Texas Standard website or listen below:
News on Open Source is free and unlimited. Access to the rest of 512tech.com comes with an American-Statesman digital subscription, which also includes myStatesman.com and the ePaper edition. Subscribe at statesman.com/subscribe.


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|European Case Law Identifier:
|Date of decision:
|18 June 2015
|Case number:
|Application number:
|IPC class:
|Language of proceedings:
|Download and more information:
|Title of application:
|Treatment of autoimmune diseases with antagonists which bind to B-cell surface markers
|Applicant name:
|Genentech, Inc.
Biogen Inc.
|Opponent name:
|01: Emergent Product Development Seattle LLC
03: Elend, Almut Susanne
06: Merck Serono SA
07: Genmab A/S
08: Wyeth LLC
|Relevant legal provisions:
|Inventive step - (no)
|Cited decisions:
|Citing decisions:
Summary of Facts and Submissions
I. An appeal was lodged by the patent proprietors (appellants) against the decision of the opposition division revoking European patent No. 1 176 981 entitled "Treatment of autoimmune diseases with antagonists which bind to B cell surface markers". The corresponding patent application was published as international application WO 00/67796.
II. The patent was opposed by eight parties (opponents 01 to 08, now respondents I to VIII) under Article 100(a) EPC on the grounds of lack of novelty (Article 54 EPC) and lack of inventive step (Article 56 EPC) and under Articles 100(b) and 100(c) EPC.
III. Opponent 01 also lodged an appeal but withdrew it at the beginning of the oral proceedings before the board.
IV. The proceedings before the opposition division constituted the further opposition proceedings, following remittal of the case by the present board in a different composition, in appeal case T 495/09 of 1 June 2010, in which it was decided that claim 1 of the auxiliary request filed on 30 April 2010, met the requirements of Article 123(2) EPC.
V. The opposition division based its decision revoking the patent on a main request (identical to the auxiliary request considered by the board in decision T 495/09, supra) and an auxiliary request, both filed with a letter dated 6 March 2012 and each consisting of a single claim.
VI. With the statement of grounds of appeal, the appellants requested that the decision of the opposition division be set aside and that the patent be maintained on the basis of the main request or alternatively on the basis of the auxiliary request. The claim of the main request read:
"1. Use of rituximab in the manufacture of a medicament for treatment of rheumatoid arthritis in a mammal, wherein the medicament is for administration with methotrexate to the mammal".
VII. The parties were summoned to oral proceedings and the board issued a communication in which some of the issues to be discussed during the oral proceedings were set out.
VIII. Respondents II to IV and VII, informed the board that they would neither attend nor be represented at the oral proceedings. Respondent III also requested that the appeal be dismissed.
IX. Oral proceedings before the board were held on 18 June 2015 in the absence of the respondents II to IV and VII. During the oral proceedings, the appellants withdrew the auxiliary request. The final requests of the appellants were that the decision under appeal be set aside and the patent be maintained on the basis of the main request. Respondents I, III, V, VI and VIII requested that the appeal be dismissed. At the end of the oral proceedings the chairman announced the board's decision.
X. The following documents are referred to in this decision:
D8 : Edwards J. and Cambridge G., British J. Rheumatol., 1998, 37, 126 - 130.
D15: Edwards J., New England J. Med., 2004, 350(25), 2572 - 2581.
D25: Edwards J. and Cambridge G., Rheumatology, 2001, 40, 205 - 211.
D56: Declaration by Jonathan Edwards dated 27 February 2008, including Appendices A to I, Appendix H consisting of Patient Records
D81: Kremer J., Arthritis Rheum., September 1998, 41(9), 1548-1551.
D82: Maini R. et al., Arthritis Rheum., September 1998, 41(9), 1552-1563.
XI. The arguments of the appellants can be summarised as follows:
Document D56 was considered to represent the closest prior art for the claimed invention. It concerned the treatment of rheumatoid arthritis (RA) with rituximab (RTX) which was based on RTX's unique mechanism of action. Document D81, on the other hand, primarily concerned the long-standing treatment of RA with methotrexate (MTX) and did not even mention RTX or biological interventions using its mechanism of action. Furthermore, document D56 represented a study carried out on patients that had repeatedly failed to respond to other conventional treatments, while document D81 was completely speculative.
Document D15 (Fig. 2) demonstrated that the combination of MTX and RTX was better than RTX alone or RTX with cyclophosphamide in the treatment of RA. Thus, when starting from document D81 as closest prior art the problem to be solved was the provision of an improved treatment of RA. The claimed solution involved an inventive step because there was no suggestion in the prior art that administration of RTX with MTX would lead to such improved treatment.
Furthermore, even not taking the evidence of post-published document D15 into account in assessing inventive step of the claimed subject-matter, the skilled person starting from document D81 would not have combined methotrexate (MTX) with rituximab (RTX) as a therapy for rheumatoid arthritis (RA) because there was no incentive in the art to do so, but rather a direct disincentive. It had to be borne in mind that document D81 had be triggered by the publication in the same journal issue of document D82, which concerned the combination of an anti-TNFalpha monoclonal antibody with MTX for the treatment of RA. In contrast to the invention, this combination aimed at inhibiting the production of human anti-chimeric antibodies (HACA) against the anti-TNFalpha antibodies, which however would not have been as concern for the skilled person considering treatment of RA with RTX because nothing in the art that suggested that HACA was a problem for patients receiving RTX. Indeed RTX functioned by depleting B-cells, which was not the case for the other types of biologic agents addressed in document D81.
A second reason why the skilled person would not have combined MTX with RTX for the treatment of RA was the state of the art would not have given the skilled person any cause to expect a synergy, in the sense of mechanistic complementarity, between the two agents in treating RA. MTX could not contribute to achieving the goal of total depletion of B-cells which was aimed at by RTX treatment.
Finally, the skilled person would have been positively discouraged from combining MTX with RTX to treat RA in patients because document D81 disclosed that the combination of MTX with biological drugs was not completely understood and was associated with certain "perils".
XII. The arguments of the respondents can be summarised as follows:
Document D81, which represented the closest prior art for the purposes of assessing inventive step of the claimed use, was a general review of what was known in 1998 about combination therapy with biologic agents in RA. In particular, it disclosed that MTX was accepted as the "most efficacious and best-tolerated single agent for the treatment of rheumatoid arthritis" (introduction, page 1548, left column). It further suggested that both existing and newly developed drugs offered considerable potential for additional therapeutic benefit when used with MTX and that these should be empirically tested in combination with MTX without waiting for a complete determination of their mechanism (page 1550, left hand column, paragraph 1).
The public prior use represented by document D56 aimed to study the utility of RTX for treating RA and did not aim at combining a biologic agent with methotrexate to treat RA and was therefore a less suitable starting point for assessing inventive step than document D81.
The technical difference between the treatment disclosed in document D81 and the claimed subject-matter was that in the claimed treatment, the biological agent to be used with MTX was RTX. The skilled person was therefore faced with the technical problem of the provision of an alternative biological agent to be used in combination with MTX in the therapy of RA or simply the provision of an alternative therapy for RA.
In view of the fact that both MTX and RTX were known as agents useful in the therapy of RA and also considering that document D81 discussed combination therapy of biological agents with MTX in RA therapy, there was a clear incentive for the skilled person to use MTX in combination therapy with any biological agent, including RTX.
In relation to the question of the alleged lack of a rationale for combining MTX with RTX in the absence a known problem of a human anti-chimeric antibody (HACA) response to RTX, it had to be remembered that document D82 disclosed RA therapy with MTX in combination with a monoclonal antibody not only to counter a HACA response but also because of MTX's known disease modifying properties.
Although document D81 mentioned certain perils and unanswered questions associated with therapy of RA by a combination of biological agents and MTX, a fair reading of the document showed that it advocated a "try and see" approach with respect to the biological agents to combine with MTX. The skilled person would therefore have combined any biologic agent with MTX.
Post-published document D15 should not be taken into account in the assessment of inventive step of the claimed subject-matter because the application as filed did not foreshadow this alleged synergistic effect. Furthermore, the document did not even disclose a surprising synergistic effect between RTX and MTX in the treatment of RA. In fact Figure 2 showed that patients receiving rituximab and methotrexate seemed to be comparatively better than those treated with rituximab and cyclophosphamide only because the patients who had been given the latter combination had not received any treatment since day 17, whereas the patients on the former were still receiving a weekly dose of MTX.
Reasons for the Decision
1. The appeal of the patent proprietors is admissible.
2. During the oral proceedings before the board, the parties were heard on the requirements of Article 54 EPC of the subject-matter of claim 1 of the main request and the board expressed its opinion on this matter. However, in view of its conclusions on inventive step (Article 56 EPC) in respect of this subject-matter, there is no need to to provide detailed written reasons for this opinion.
Claim construction
3. The board considers that the skilled person would understand that the medicament to be prepared according to the claimed use (see Section VI.) may comprise rituximab (RTX) alone or may comprise both RTX and methotrexate (MTX) and that the claim is for uses involving the deliberate treatment of rheumatoid arthritis (RA) with both of RTX and MTX. Since the claim includes no indication of timing or sequence of the administration of either active component, the RTX containing medicament to be manufactured according to the claimed use may be administered with MTX separately or together, at the same time or at a different time. The RTX and MTX may be administered in either order.
Inventive step - Article 56 EPC
The closest prior art
4. There was a difference in opinion between the parties as to which document represented the closest prior art for the claimed invention. The appellants chose document D56, whereas the respondents selected document D81, as did the opposition division in the decision under appeal.
5. Document D81 is an editorial in a scientific journal concerning combination therapy of RA with MTX with certain biological agents, in particular, monoclonal antibodies. Document D56 is a declaration by Professor Jonathan Edwards, dated 27 February 2008, relating to a five patient open label clinical study aiming to investigate the treatment of RA with RTX. The document includes appendices A to H, where appendix H is a set of record sheets of patients participating in the study. The public availability of the study and the treatments used was not disputed by the appellants.
6. It has been established in the case law of the Boards of Appeal that, where more than one document is cited as the closest prior art, the one which must be deemed the closest is that which provides the skilled person with the most promising springboard to the invention (see Case Law of the Boards of Appeal of the European Patent Office, 7th edition, 2013, I.D. 3.4.).
7. In the present case, in deciding which of documents D56 or D81 should represent the closest prior art for assessment of inventive step of the claimed subject-matter, the board recognises that both documents are good candidates. However, the board has satisfied itself that the claimed subject-matter was not inventive when starting from the disclosure of document D81 (see point 18., below). This document may therefore be taken to represent the closest prior art.
Problem to be solved
8. The difference between the disclosure of document D81 and the claimed invention lies in the choice of RTX as the biological agent to be administered with MTX.
9. The appellants argued that treatment of RA with a combination of MTX and RTX provided an unexpected therapeutic synergy. The evidence for this therapeutic synergy was to be found in document D15. Accordingly, the problem to be solved was the provision of an improved treatment of RA.
10. In accordance with the case law of the boards, reformulation of the problem to take a technical effect into account is only allowable, if the new problem can be deduced from the application as filed. In the same vein, the case law of the boards has consistently held that post-published evidence to support that the claimed subject-matter solves the technical problem underlying the invention, is taken into account only if it is already credible from the disclosure in the patent that the problem is indeed solved (see Case Law of the Boards of Appeal of the European Patent Office, 7th Edition, 2013, I.D. 4.4.1, 4.4.2 and 4.6). In other words, a subsequently invoked technical effect cannot be taken into account when determining the problem underlying the invention if it could not be deduced by the skilled person from the application as filed (see Case Law of the Boards of Appeal of the European Patent Office, 7th Edition, 2013, I.D. 4.4.2).
11. The board notes that document D15 was published after the effective date of the patent in suit. Moreover, the board cannot identify in or deduce from the patent any disclosure of a synergistic effect between the two agents which would amount to a teaching to be backed up by the disclosure of document D15. The disclosure of document D15 is therefore not taken into account in the assessment of the inventive step of the claimed subject-matter.
12. Accordingly, starting from the disclosure in document D81, the technical problem to be solved is the provision of an alternative biological agent (drug) to be used in combination with methotrexate for the treatment of rheumatoid arthritis.
13. The question to be answered by the board is whether the skilled person starting from therapies for RA disclosed in document a document D81 and seeking a solution to the above formulated technical problem, would have considered administration of MTX with RTX for the treatment of RA.
14. Document D81 teaches that methotrexate (MTX) was accepted as "the most efficacious and best-tolerated single agent for the treatment of rheumatoid arthritis (RA)". The treatment of RA with the biological agent RTX was also known to the skilled person, at least from the public prior use represented by document D56. Neither of the above facts is a matter of dispute among the parties.
15. Document D81 discloses that RA patients would benefit from a lowering of the weekly dose of MTX administered (see document D81, page 1548, column 2, penultimate paragraph). That such a lowering might be achieved through the combination of MTX with a new "biotechnology" agent is also disclosed. On the subject of "[w]hich combination [of biologic agent and MTX] makes the most sense" document D81 concludes that "[b]ecause of these uncertainties about the mechanism of action of MTX and cytokine inhibition, neither TNFalpha or IL-lbeta inhibitors can claim to be inherently better positioned to promote their use with MTX as making the most conceptual sense. Therefore, these and other biotechnology interventions are, quite reasonably, being empirically combined with MTX while hoping for the best. This approach can, and should, be advocated because our patients simply do not have the time to wait until we determine how all of the new and existing drugs work, let alone how MTX works" (page 1550, column 1, paragraph 1). Document D81 furthermore states: "Nevertheless, the current practice of combining virtually all new agents with MTX, the drug of many therapeutic possibilities, makes it likely that the cart will come before the horse. That is, we will empirically determine the combinations which result in the very best clinical efficacy and then investigate the effects on the immune and inflammatory cascade. This has been the scenario which has occurred with MTX as monotherapy as the scientific community began to recognize its clinical value" (page 1550, paragraph 2; emphasis added by the board).
16. In summary, the board concludes that document D81 suggested to the skilled person that the standard therapy of RA with MTX could be improved by administering it in combination with biological agents, in particular antibodies, newly developed for the treatment of RA. Given the urgency of the need for improved treatments, rather than waiting for a complete understanding of the mechanism of action of such agents or indeed of a complete understanding of the mechanism of action of MTX, an empirical approach to combination therapy was advocated. Following this empirical approach, the skilled person would have considered treating RA in a patient by administering MTX in combination with any new biological agent developed to treat RA. Thus, given that RTX was one such newly developed biological agent, the board takes the view that the skilled person had an incentive to administer MTX in combination with RTX to treat RA.
17. The appellants submitted that the skilled person, starting from document D81 as closest prior art, would not have combined MTX with RTX as a therapy for RA because there was no scientific rationale for combining the two agents and also because the disclosure of document D81 provided a disincentive to the skilled person concerning such combinations (see section XI.XI. ). However, in view of the board's conclusion that document D81, contrary to the appellants' views, provided the skilled person an incentive to empirically combine any new biological agent developed for treating RA, with MTX for the treatment of RA, regardless of the mechanism of either agent, these arguments cannot succeed.
18. Thus, the board concludes that the subject-matter of claim 1 lacks an inventive step.
For these reasons it is decided that:
The appeal is dismissed


text:
Amberjack (Seriola dumerili) are caught in the Gulf of Mexico as well as the Atlantic Ocean. Amberjack are large jacks (160 lbs max) that are blueish to olive in color with a silver or white belly. They also have an olive band that extends from the eye to the origin of the dorsal fin. Oh heck just look at the pictures. Amberjack are found from the coast to well offshore but are most common in water of over 100 ft and most common is water of 300 ft. depth. Amberjack are schooling fish.
Amberjack are a prized gamefish that is known for its strong powerful line busting capability. Amberjack are structure loving fish. Oilrigs and shipwrecks are some of their favorite haunts.
Key Notes and Tips:
*Large jigs are the most frequently used artificial to catch Amberjack.
*When jigging for Amberjack it is important to try to keep the jig moving rapidly up and down as you bring it up, Amberjack aren't likely to hit slow moving artificials.
*Amberjack have been known to carry ciguatera poisoning in the Carribean.
*If you want to catch Amberjack on light tackle it is a good idea to chum them to the boat. This will make it much easier to keep them out of line cutting structure.
*When rig fishing for Amberjack the best method is to place a live hardtail that has had its tail clipped on a hook and lowered down into the depths.
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Subject: Forum Rules
Mon Sep 06, 2010 11:17 am
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We do not encourage the sharing of pornography / gore through private messaging, but we have no control over whether you do it or not.
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Essays dreams my father
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Words of Support and Encouragement Week of November 22, 2010
Taking a breath, and possibly a pose, may help you move swiftly through the holidays. As we are welcoming the harvest of Thanksgiving this week, remember to take some time for yourself. It is easy to get preoccupied with food and family. However, it is important to remember to nurture and love yourself. Tomorrow, Tuesday November 23rd at 7:00pm I am holding an Evening Meditation and Relaxation Webinar. I will walk you through a meditation to help you unwind from the day, and prepare for a good night of sleep. Visit this link to register to join me https://www1.gotomeeting.com/register/718621224
Our CNY Healing Arts Centers will be closed on Thanksgiving day, but open for the rest of the week. A recent study featured in The Journal of Alternative and Complimentary Medicine highlighted breakthrough research finding that a consistent yoga practice resulted in greater improvements in mood and anxiety level, than a walking regimen. If you are feeling that you could use an extra boost in mood this week, try a yoga class! The combination of patient breathing, energizing sequences, and calming poses will surely prepare you for a relaxing holiday season.
For more information about our CNY Healing Arts offerings and yoga schedule, please consult our calendar: http://www.cnyhealingarts.com/discussion/calendar.php
Enjoy your holiday!


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Kanye West Gives Sneak Preview of New Book
Kanye West posted three pages from his upcoming book, 'Thank You and You're Welcome' -- an "entertaining volume of "Kanye-isms" -- which features gems like 'Be Leery of the Free Gift Bag' and the 'Missing Banister Theory,' on his kanyeuniversecity.com blog on Monday.
On the 'Get Used to Getting Used' page, West cleverly explains why being "used" isn't such a bad thing. "To most people, the saying 'to use someone' carries a negative connotation. But I don't see it that way. To 'mis,' 'over' or 'ab'-use someone is negative. To use is necessary. And if you can't be used, you're useless," the rapper explains.
'Thank You and You're Welcome', co-written with J. Sakiya Sandifer, is available for pre-oder on West's official Web site for $10.
In other West news, the rap star has launched his own search engine, searchwithkanyewest.com. The unique site -- powered by Google and Ask.com -- will allow users to earn rewards each time they search the internet via the engine. Users can earn Swag Bucks, which can be redeemed for autographed items, concert tickets, iPhones and game systems.


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It has been a while since political bickering over who can piss the farthest was an issue of global concern. Today, China communist party's mouthpiece People's Daily has released an essay in which the country once again resorts to thinly veiled threats against the US, and demands that not only the country's territorial demands in the South China Sea be uncontested, but that the US accept China as a global power , as the alternative could promptly generate the appearance of rocky relations between the two countries and "no one would like to see the negative effects rocky relations would bring to China, the United States and possibly to the world as a whole." Of course, with China the world's biggest creditor nation, and holder of anywhere between $800 billion and $1.2 trillion (assuming all that London flotsam is really Chinese stealth accumulation), Beijing can rest assured the essay has been duly noted. Of course, with the administration doing one wrong thing after another, it would not be at all surprising if the president's advisory henchmen seek to push the tenous relationship as far as it can go, and truly test the decoupling (this time it IS different, Jim O'Neill said so) hypothesis, however with nothing but downside if decoupling is finally proven true (breath holding not advised).
The U.S. government has repeatedly made it clear that it would welcome China's entrance into the world arena as a power. However, a series of issues since the beginning of this year, particularly Washington's stance on the U.S.-South Korean joint military exercises and the South China Sea issue, have made the world think: Is the United States ready to recognize China as a power on the world stage?
It is easier said than done for the United States to adapt itself to China's development. Lip service is far from enough to boost the development of Sino-U.S. relations. If Washington cannot find a way to recognize and accept China's peaceful rise onto the world stage, bilateral ties will be like a roller coaster full of ups and downs. However, no one would like to see the negative effects rocky relations would bring to China, the United States and possibly to the world as a whole.
Originally posted by Romantic_Rebel
reply to post by sadchild01
The greedy people in government are at fault. More so the American people for allowing these criminals to take control of our country.
They can simply stop shipping us batteries
Originally posted by ~Lucidity
Empty threats? Let me put this simplistically, without all the economic mumbo jumbo smoke and mirrors designed to confuse.
China has the power NOW to bring the U.S. to its knees.
And they don't have to do it militaristically or "econonically" either.
They can, but they don't have to. They can simply stop shipping us batteries and a few other silly essentials, and we'd be screwed.
Whether the U.S. "recognizes" China as a world power or not in irrelevant. China is a world power.
And YOU and the U.S. helped put them there.
Yes, folks...China...another threat brought to you by the same American brainiacs who scared you about Middle Eastern terrorism while at the same time leaving your borders wide open.
Brought to you by the same folks who let our money bleed offshore and are now surprised that there's no tax base.
Brought to you by your sham of a non-American plutocratic government.
Who are the fools?
[edit on 7/30/2010 by ~Lucidity]


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Tales of the Bloodstone Lands
The shouts and bustle of countless traders, fishermen, and foreign travelers stir the choppy waters of Merchant's Cove through all hours of the day and night. Along the lakeside district of Lakestone, storefronts and cramped businesses cater to the typically rough fishermen, while exotic inns and taverns serve as familiar welcomes to visitors from afar. First and foremost a trade city, Bloodstone City owes its prosperity to the countless merchants who readily move the Bloodstone mined in the Duchy out and bring all manner of trade goods and luxury items in. Enforcing no taxes on exports or imports, the city welcomes business from all lands and makes the bounty of the mines available for trade. As a result, several of the most prestigious trading coasters, mercantile families, and shipping concerns do regular business in the city, with some having even established offices and private local shipyards.
Lakestone's most incredible feature is the sprawling Bloodstone Free Market, yet the district itself is more than merely one enormous market. The lakefront is a constantly bustling scene of activity as fishermen and trading barges vie for dock space, and even the neighborhoods farthest from the shore are noisy and raucous. The large number of fishing eagle nests are the source of the area's less common name, "Eagle's Quarter." The streets here are cobblestone, and buildings are an equal mix of stone and wood. Streets are patrolled regularly, yet the high volume of traffic make it difficult for the guards to always keep the peace.
Population 1,310 permanent, 760 itinerant
L1. Impound Yard (piers used to temporarily dock impounded ships)
L2. Dweomerstone (Temple of Mystra)
L3. The Blessed Coin (Temple of Waukeen)
L4. Librarium of Denier (Library and Temple of Deneir)
L5. Merchants' Guildhall (fortress-like stone building that houses Bloodstone's most powerful guild)
L6. Fellowship of Bartenders and Innkeepers (tavern keepers' and innkeepers' guild)
L7. Bakers' Guild (pastry and bread maker's union)
L8. Brewers' Guild (small but powerful association of ale, beer, lambic, and other brewers)
L9. Cobblers' Guild (union of cobblers; rumored to be under Sczarni control)
L10. Tailors' Guild (humble wooden structure that supports tailors)
L11. Merchant's Cove (Bloodstone's alternate harbor)
L12. Four Brothers warehouse and offices (successful merchant company)
L13. Warehouse Square
L14. Bloodstone Free Market
L15. Carent's Camp (Vaasan campsite)
L16. Hook and Hammer (successful trading concern run by three dwarven brothers)
L17. Bronze House (Merchant Consortium regional headquarters)
L26. Veldar's Metalworks (Laethwym Veldar elven smith)
L27. Voor's Smithy (Felgin Voor human smith)
L18. King's Arms Inn and Tavern
L19. Captain's Club (high-class but affordable tavern; caters exclusively to ship captains)
L20. Basilisk's Eye (no-nonsense tavern surrounded by warehouses; caters primarily to dockside laborers)
L21. No-Horn (low-end and unpleasant Lakestone tavern)
L22. The Old Fang (popular waterfront tavern and inn)
L23. The Shucked Oyster (scandalous and popular brothel)
L24. The Fifth Wind (towering stone weather vane)
L25. Eyes of the Hawk (monument dedicated to the heroism of King Dragonsbane and his band of adventurers)
Bloodstone City
Duchy of Bloodstone


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Events between 04/16/2018 and 04/30/2018
in BRPM Monthly Print Calendar
John M. Parker Coliseum, LSU, through April 22 from 10 a.m.-3 p.m. Free interactive, visually stimulating environment that takes you on a journey of Louisiana agriculture and economically beneficial commodities used every day. lsuagcenter.com
Festival of Two Rivers
in BRPM Monthly Print Calendar
St. Alphonsus Church through April 29. Games, rides entertainment, food, drinks, sweets, Kiss the Goat, and BBQ chicken dinner on April 29. (225) 261-4650
St. John's Festival de la Prairie
in BRPM Monthly Print Calendar
St. John the Evangelist Catholic Church, Prairieville, through April 29. Carnival rides, music, food, silent auction, raffles, and races. stjohnchurch.org
Planetarium Family Hour and Stargazing
in BRPM Monthly Print Calendar
LASM on Saturdays at 10 a.m. Gather around the campfire to learn about stars and constellations in the local nighttime sky, then enjoy a planetarium show. lasm.org
Tall Ships New Orleans
in BRPM Monthly Print Calendar
Woldenberg Riverfront Park, New Orleans, through April 22. Part of the New Orleans Tricentennial celebration and in conjunction with Navy Week. Free and open to the public. tallshipsnola2018.com
Angola Prison Spring Rodeo
in BRPM Monthly Print Calendar
Louisiana State Penitentiary through April 22 with gates open from 9 a.m.-5 p.m. and the rodeo show at 2 p.m. angolarodeo.com
The Italian Festival
in BRPM Monthly Print Calendar
Highway 51 next to City Hall, Tickfaw, through April 29. Live music, carnival rides, parade, and spaghetti cook-off. Free admission. Carnival ride armbands are $25. theitalianfestivalorg.com
Third Street Songwriters Festival
in BRPM Monthly Print Calendar
Downtown at various venues through April 22. Annual event with local, regional and national songwriters. thirdstreetsongwritersfestival.com
3D Printer Demonstration
in BRPM Monthly Print Calendar
Pride-Chaneyville Library at 4 p.m. Teens can learn about how this machine transforms a digital design into a physical object. (225) 658-1550
Pregnancy 101
in BRPM Monthly Print Calendar
Woman's Hospital from 6:30-9 p.m. Learn how to provide your baby with the best possible environment for growth and development. Wear slacks or shorts so you can practice the exercises with the fitness instructor. Cost is $25. Registration required. (


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Suggested Driving Routes & Itineraries
NH Open Doors is a great way to experience the best that New Hampshire has to offer. Create your own driving route and visit the locations that interest you or choose from one of the following itineraries suggested by NH Open Doors participants. Because NH Open Doors participants are located all over the state, you are you are bound to explore at least one part of the state that is new to you. And while you are touring, you'll also find countless restaurants and lodging accommodations to suit your taste and budget.
Check back for the 2018 itineraries.


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Clerical Support roles provide administrative support in scheduling, data entry, auditing, medical record filing and retention, order tracking and other support as requested. They are often responsible for patient registration and discharge, maintenance of patient records, customer service including scheduling appointments, answering patient inquiries and greeting visitors in a compassionate, professional and respectful manner.
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