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In special shoes, LeBron's triple-double leads Cavs past Wiz
- Written by By HOWARD FENDRICH , AP Sports Writer
WASHINGTON (AP) — LeBron James joked that he changed out of his shoes — one black, one white, with "equality" in gold capital letters — at halftime because he was playing poorly.
Cleveland Cavaliers forward LeBron James (23) goes to the basket against Washington Wizards guard Jodie Meeks, left, and forward Mike Scott (30) during the first half of an NBA basketball game, Sunday, Dec. 17, 2017, in Washington. (AP Photo/Nick Wass)
"If that's a bad game," teammate Kevin Love said, "then sheesh!"
James finished with 20 points, 15 assists and 12 rebounds to lead the Cleveland Cavaliers past the Washington Wizards 106-99 on Sunday night for their 18th victory in 19 games, and then said afterward his choice of footwear was related to the game being played about a mile from President Donald Trump's White House.
"This is a beautiful country and we're never going to let one person dictate how beautiful and how powerful we are," the four-time NBA MVP said.
James had his fourth triple-double in the past five games despite being called for four fouls in the final quarter.
Still, he offered a scathing self-critique.
"I actually played pretty bad tonight. I wasn't as strong with the ball: I had six turnovers. Kind of lazy with the ball, at times," James said. "And my teammates did a great job bailing me out."
Love led Cleveland with 25 points and added nine rebounds. Jeff Green added 15 points, and Kyle Korver scored 11.
"He just affects the game in so many ways and makes a lot of plays for other guys, too," Love said about James. "He's just setting us up and getting us into our spots. That's what he does. He's our leader."
The last time these teams played, at Washington on Nov. 3, Cleveland won thanks to 57 points from James.
That prompted Wizards coach Scott Brooks to joke before tipoff Sunday that holding the four-time league MVP to "56 would be pretty good tonight." He also cracked, "I have a lot of respect for Coach (Tyronn) Lue, but I think he's making a bad decision if he doesn't sit LeBron tonight. Back-to-back games, right? Our fans saw 57. They don't need to see any more."
This time, James was more of a facilitator.
"His IQ is the highest I've ever been around," Brooks said afterward. "Just the way he sees the floor."
Bradley Beal led Washington with 27 points, and John Wall had 15 points, 10 rebounds and six assists in 32 minutes in his third game back after missing nine with an injured left knee.
In a matchup of Eastern Conference division leaders, neither team led by more than seven until Wall turned the ball over, leading to a fast break for James, who was fouled at the other end and completed the three-point play for a 103-94 lead.
That was part of a 23-16 edge for the Cavs in the fourth quarter, which began with the teams tied at 83.
"Against a great team like that, you have to be sharp the whole game," Wizards forward Mike Scott said. "In the fourth, we weren't sharp on the offensive end, and they made plays."
Cavaliers: G Dwyane Wade was rested on the second half of a back-to-back. ... The Cavs finished with 24 assists, ending their streak of three consecutive games with at least 30. ... Cleveland made 14 3-pointers, its 20th game in a row with at least 10. ... The Cavs scored at least 100 points for the 24th straight game.
Wizards: F Otto Porter Jr. sat out with an injured right hip. ... His replacement in the starting lineup, Kelly Oubre Jr., had 11 points and eight rebounds. ... F Markieff Morris missed the start of the second half because he was getting an X-ray on his neck. "Everything came back clean," Brooks said.
If it seems as if James climbs up some career list each and every night, well, that's because he pretty much does. This time, he overtook Hakeem Olajuwon for ninth-most made field goals in NBA history and tied Nick Van Exel for 24th-most 3-pointers. ... Wall's 3 shortly before halftime moved him up to No. 5 on Washington's franchise scoring list. He began the night at No. 7, but surpassed Phil Chenier and Gus Johnson in the second quarter.
Cavaliers: At Milwaukee on Tuesday night. The Cavs have beaten the Bucks the last five times they've played.
Wizards: Host New Orleans on Tuesday night.
LeBron wears 1 black shoe, 1 white shoe, speaks about Trump
By HOWARD FENDRICH , AP Sports Writer
WASHINGTON (AP) — LeBron James made a statement during an NBA game with his shoes — one black, one white, with the word "equality" in capital gold letters on the back of each.
Cleveland Cavaliers forward LeBron James' shoes are emblazoned with "EQUALITY" on both heels during the first half of an NBA basketball game against the Washington Wizards, Sunday, Dec. 17, 2017, in Washington. (AP Photo/Nick Wass)
Then, after the game, James made a statement about President Donald Trump, saying: "This is a beautiful country and we're never going to let one person dictate how beautiful and how powerful we are."
The four-time NBA MVP was asked about his choice of footwear for the first half of his Cleveland Cavaliers' 106-99 victory over the Washington Wizards on Sunday night at an arena about a mile from the White House.
"Obviously, we know where we are right now," James began. "And we know who's at the helm here."
He continued, speaking about the importance of "having equal rights and being able to stand for something and speak for something and keeping the conversation going."
James then referred to his past discussions of Trump, saying: "Obviously, I've been ... very outspoken and well-spoken about the situation that's going on at the helm here. ... Equality is all about understanding our rights, understanding what we stand for and how powerful we are as men and as women, black or white or Hispanic. It doesn't matter your race."
Earlier this year, James called Trump "a bum" on Twitter and also said at Cleveland's preseason media day: "He doesn't understand how many kids, no matter the race, look up to the president of the United State for guidance, for leadership, for words of encouragement. He doesn't understand that, and that's what makes me more sick than anything."
Then, for Cleveland's first regular-season game, James donned a pair of black sneakers with the "equality" message. But this was the first time James chose to wear one white and one black shoe.
At halftime Sunday, he changed into other sneakers. James finished the game with 20 points, 15 assists and 12 rebounds.
"I didn't play well in the first half, and I'm very superstitious, so I took 'em off," James explained, before joking: "I didn't play well in the second half, either, so if there was a third half, I would have took those off."


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ATLANTA – Registration is open for the Brightree Summit, the company's one-day user conference. The Summit will take place Oct. 15 at the Omni Atlanta Hotel in conjunction with Medtrade.
WASHINGTON – CMS has published guidance for power mobility device providers on the transition to the national prior authorization program.
Cape Coral, Fla.-based Merits Health Products has named Joe McKnight as its western regional sales manager.
NEW ORLEANS – Option Care has opened its first care management center in Louisiana, the home infusion provider announced Aug. 7. The center opened June 11 in Elmwood.
MINNETONKA, Minn. – An alternative to CPAP therapy has been approved by CMS for a new technology add-on payment to hospitals.
PITTSBURGH – Circadiance has received two additional patents for its SleepWeaver line of soft cloth CPAP masks. The U.S.
SAN DIEGO – ResMed has reported revenues of $623.6 million for the fourth quarter of fiscal year 2018, a 12% increase compared to the same period of 2017.
AUBURN, N.Y., and BUFFALO, N.Y. – Homecare Medical Supply in Auburn, N.Y., has become a branch of Respiratory Services of Western New York in Buffalo, N.Y., according to the Olean Times Herald.
BILLERICA, Mass. – Insulet Corp., maker of the Omnipod Insulin Management System, reported revenues of $124.3 million for the second quarter, a 13% increase compared to the same period last year.
ASHEVILLE, N.C. – Aeroflow Breastpumps, a subsidiary of Aeroflow Healthcare, has launched a contest for a Pumping Room Makeover as part of World Breastfeeding Month.
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Studying About Seamless Gutter Installation
Learning About Seamless Gutter Installation
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I have the following bit of javascript in an extension object. The purpose is to update data structures in the extension object whenever another chart (on the same sheet as the extension object) is altered either by sorting or selection.
var doOnce=0;
Qva.AddExtension("myExtension",function() {
if (doOnce==0) {
this.GetQvObject("myStraightTable",function() {
var chart = this;
// examine chart contents here and set global vars.
This works... for a little while.. and then things go south with unexpected exceptions, refresh freezes, lost connections, etc.
I can implement the same code and access an input box without any problems, but when I try to access the straight table, erratic behavior eventually arises. I don't even have to do anything with the char variable to have problems; simply declaring a handler on a straight table seems to be problematic to the stability of the system.
I've also tried using:
Qv.GetCurrentDocument().GetObject("myStraightTable",function() {
var chart=this;
// chart processing
Qva.AddExtension("myExtension",function() {
// extension processing
and got the same problems. Any ideas what's going wrong?


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How to delete interface docker0
I would like to remove the interface docker0. It would be better to avoid creating the interface docker0 when starting the service and using directly the eth0.
One Solution collect form web for "How to delete interface docker0"
By default, the Docker server creates and configures the host system's docker0 interface as an Ethernet bridge inside the Linux kernel that can pass packets back and forth between other physical or virtual network interfaces so that they behave as a single Ethernet network.
Look at Understand Docker container networks and Customize the docker0 bridge
When you install Docker, it creates three networks automatically. You can list these networks using the docker network ls command:
$ docker network ls
Historically, these three networks (bridge, none, host) are part of Docker's implementation. When you run a container you can use the –network flag to specify which network you want to run a container on. These three networks are still available to you.
The bridge network represents the docker0 network present in all Docker installations. Unless you specify otherwise with the docker run –network= option, the Docker daemon connects containers to this network by default. You can see this bridge as part of a host's network stack by using the ifconfig command on the host.


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| Motion Graphics, Apple
Interactive Television Producer / Multimedia Specialist / Inventor/Animatronics repairman
Professional Television production since 1998
Multimedia Specialist and programming since 2000
Professional VJ experience since 2009 (6 years apprenticing prior)
Adobe Photoshop experience since 1994
Created the world's first center perspective 3D zoetrope.
Created a visual theremin from a NES.
Augmented Reality experience since 2009
HTML5 experience since 2011


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Hip-hop star Ty Dolla $ign released his new album, Beach House 3, on Oct. 27. He teams up with his girlfriend Lauren Jauregui on the standout track "In Your Phone."
Beach House 3 is the second studio album by Ty Dolla $ign and the third installment in the Beach House series, which includes two mixtapes. There are collaborations galore on the record, but the most special one is with Fifth Harmony member Jauregui, who Ty recently revealed he is dating.
Ty Dolla $ign penned "In Your Phone" with Jauregui and producers Dun Deal and MariiBeatz. A twinkling trap beat backs the couple trading verses about wanting more attention from one another. Ty flexes his singer side in a soaring performance. Lauren meanwhile has flow on her verse and reiterates his relationship frustrations. "You always in your phone / I feel like you do me wrong," they sing together. The two really connect on this hypnotic hip-pop collaboration.
"In Your Phone" is now available on iTunes and Apple Music alongside the Beach House 3 album. Ty Dolla $ign will perform at the Grammy Museum in L.A. on Nov. 28.


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Professional translator from Buenos Aires, Argentina
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Man United faces 3 months without defender Eric Bailly
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December 12, 2017
Trump wants to send man back to the moon - and eventually Mars
Bush also pledged to send Americans to the Moon as part of the Constellation program, which ran from 2005 to 2009. The last time U.S. astronauts visited the Moon was during the Apollo missions of the 1960s and 1970s.
December 12, 2017
Israeli army destroys tunnel from Gaza
Smoke was seen rising from the Gaza Strip, where the area where the attack was reported to have taken place. Palestinians say the two killed were members of the Al-Quds Brigade, the military wing of Islamic Jihad.
December 10, 2017
'Zelda,' 'Cuphead,' 'Hellblade' triple winners at The Game Awards 2017
Nintendo previously said " The Champion's Ballad " would arrive in "December", but never put a release date on it. Best Action-Adventure Game, Best Direction, Game of the Year; these are elite categories.
December 10, 2017
Apple in talks to buy Shazam for $560m
Truthfully, there have been many rumors as to how much exactly the popular technology company will be buying Shazam for. With the popularity of Shazam's iOS app, it is clear that Apple users want this sort of functionality in their phones.
December 07, 2017
Dhoni may return as CSK skipper after new IPL rule
For the 2018 IPL season, the salary budgets for the IPL teams have also been increased to 80 crores from 66 crores. Each franchise team will have a maximum of 25 players (up to eight foreign) and a minimum of 18 players.
December 07, 2017
A raging fire is encroaching on celebrity homes in Los Angeles
Over 125 firefighters have been on the scene, and water-dropping helicopters are reportedly being used to quench the flames. Classes were canceled at all schools in the Ventura Unified School District on Wednesday.
December 06, 2017
HP and ASUS unveil Snapdragon-powered laptops
Qualcomm is hosting its annual conference this week, where we expect to hear more about Snapdragon Windows 10 devices. But what's really special about Always Connected PCs is that they're ARM-based, just like most Android smartphones.
December 05, 2017
'House Of Cards' back on - without Kevin Spacey
Netflix cut all ties with the actor , not only in house of Cards but also in the upcoming film All the Money in the World . Deadline reports that it will be an abridged season of eight-episodes used to wrap things up in a satisfying manner.
December 03, 2017
Mom's boyfriend arrested in missing Jacksonville toddler case
Family members said Kimrey lived in the home with Mariah and her mother; photos on Facebook show the pair together with Mariah. The FBI says they have been sending "items of interest" to their lab in Quantico, Virginia, for priority testing in the case.
December 03, 2017
Trump responded to the launch of ballistic missiles by Pyongyang
With few other levers of power, Democrats are under pressure from their core voters to extract as many concessions as they can. The meeting was meant to discuss the year-end spending bill to keep the federal government running and avert a shutdown.


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Research papers on obesity in teenagers
Read the latest medical research on obesity brain's self-regulation in teens at risk for obesity thursday get sciencedaily's obesity news. Nber working paper series the effect of fast food restaurants on obesity and and do not necessarily reflect the views of the national bureau of economic research. Read this essay on obesity research has shown child and teen obesity in the united states has grown considerably in recent years. Nhpf background paper july 11, 2003 obesity in america: a growing threat eileen salinsky, principal research associate wakina scott, research associate.
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Lisa's Creative Designs is an online boutique, blog and design studio that embraces cottage style and a country living lifestyle. Lisa's offers a wonderful selection of personalized gifts, vintage goods and country cottage decor that have a handmade touch. You can shop for a variety of one of a kind creations and cottage decor you can only find at Lisa's Creative Designs. Whether you have a cottage by the sea, a vintage French country farmhouse or a Shabby Chic inspired home, you are sure to find something special at Lisa's that will make your house feel like home.
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We're just in Estonia- a small, beautiful country on the Baltic Sea- for a couple of weeks for holidays.
I'm not quite used to having holidays in the middle of the year, being from Australia, and keep having fleeting feelings like it's Christmastime. On the ferry last night they had some children's entertainers dancing in rabbit and penguin suits and was confused for a moment.
It constantly surprises me how your physical perceptions are so programmed by your experience.
Very nicely on the walls they had two Van Gogh posters. Kandinsky decorated the hallways. Van Gogh just brings that earthy, summer heat to you especially if it's raining outside.


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Nick Morfogen, executive chef and partner of 32 East restaurant in Delray Beach, will join a team of chefs preparing dinners at private residences as part of "Boca Bacchanal, A Winefest and Auction."
But Morfogen still is not sure what he'll cook for the three-day fund-raiser sponsored in March by the Boca Raton Historical Society.
"I really won't make that decision for a few more weeks yet," he said. "Not until I get the list of wines and notes from the vintner. Once I get those, I'll start putting together the menu."
Paired with winemaker Tom Selfridge of Chalone Wine Group of Napa, Calif., Morfogen will script his menu, choosing the entrM-ie and in-season vegetables to complement the vintner's choice of wines.
"I will also take into consideration any food allergies guests might have," he said.
He will start preparing the sauces several days before the event, but won't do any cooking until that night. "It's both an exciting and anxious time. There's always the potential for failure," he said.
The events from March 19 to 21 include the vintner dinners, a luncheon featuring a casual wine and food tasting, a grand finale auction and dinner, and a champagne brunch.
Thirteen chefs from the United States, one from Italy and 11 vintners, including some from Australia, Italy and France, will take part.
A pre-event wine tasting will be held Feb. 5 at Arturo's Restaurant in Boca Raton.
The first "Boca Bacchanal" last year attracted more than 1,500 participants, so the society plans to stick with the same format.


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Publications about Nature, landscapes and biodiversity
In the face of urgency of addressing global sustainability challenges and limited political will and capacity at national and international...read more
The 2nd Policy Forum on Natural Capital Accounting for Better Decision Making was held in November 2017, in The Hague, organised by PBL...read more
The Emerging Governance Landscape around Zero Deforestation Pledges. Insights into dynamics and effects of zero deforestation pledges.
Voluntary commitments to eliminate or reduce deforestation are developing into a powerful framing of global activities to combat deforestation and...read more
Pathways for agriculture and forestry to contribute to terrestrial biodiversity conservation: a global scenario-study
While there has been an increase in the societal responses to biodiversity loss, in most cases this will not be sufficient to achieve the...read more
In 2015, the Dutch working group on discount rates recommended using the standard discount rate in cost-benefit analyses (CBAs) of nature, while...read more
This scoping report looked into the potential impact of so-called 'International Cooperative...read more
This report presents the first comprehensive assessment of the global consequences of the land-water-energy nexus in the coming decades. It...read more
New EU-scale environmental scenarios until 2050 – Scenario process and initial scenario applications
As part of the Openness project, new EU scenarios focusing on natural capital and ecosystem services were developed. These were applied at...read more
Exploring future changes in land use and land condition and the impacts on food, water, climate change and biodiversity: Scenarios for the UNCCD Global Land Outlook
The pressure on land is growing in many regions of the world, due to the increasing demand for arable crops, meat and dairy products, bio-energy...read more
Halting biodiversity loss in the EU requires substantial policy action. The Nature Outlook study elaborates four perspectives on the future of...read more


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The Correct Way to Weight Yourself! I can't believe I was doing it wrong all these years!
Laziness is the mother of all bad habits but ultimately she is a mother and we should respect her!
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Spartiti per Pianoforte
Descrizione, Contenuti:
This book offers a complete course for Drumkit, Snare Drum, Timpani and Tuned percussion. Modules 1 and 2 cater for the student at beginner to intermediate level. It starts from the absolute beginning and progresses in a sensible, understandable way. There are separate sections for each instrument and every page is designed to be a structured lesson, suitable for either the individual player or a group. A CD with backing tracks is also included, which makes practice easy and fun. The book is also designed to satisfy the needs of the modern percussion tutor. There are suggested warm up exercises and ensemble pieces included in each module. It follows the principles and values of A Common Approach Percussion curriculum and also gives a scheme of work that prepares students for graded music examinations.


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Nathan's Hot Dog Eating Contest: Here's How Much the Winners Make
You might be fascinated by the amount of hot dogs consumed every year at Nathan's Hot Dog Eating Contest, but you might be even more surprised to learn how much the winning contestants make.
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Latest Blog Posts
Phone: 0203 637 1440
10 Tips to Beat the January Blues
It can be hard to find your enthusiasm for your day job when you've just spent 2 weeks eating, drinking and being merry with family and friends, however without your day job, you'll soon be in a pickle so here are some top tips for finding your energy for the new year ahead.
1. Eat Well
Have a detox, cut out alcohol, eat lots of fruit and vegetables. The Christmas excess can leave you feeling bloated due to too much salt, fat and sugar - and alcohol is a know depressant. Be kind to your body by giving...
Read More
10 things we think make Britain great.
1. Funny Place Names
You literally couldn't make them up; take this small sample of British place names - someone, somewhere is having a laugh.
Prickwillow, Cockermouth, Sodom, Bush, Bell End, Cockshutt, Dicker, Fannyfield, Weeford, Upperthong, Shitterton, Badgers Mount, Brown Willy, Pratt's Bottom, Looe, Muff, Tarty Burn and Twatt. Not forgetting the River Piddle which flows to Puddletown in Dorset. There are so many more we could list here, but we are scared that our blog will get banned if we put them all in.
2. Sense...
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The Olympics and The Property Market (through our eyes)
After 8 anxious years of expectation, preparation and exasperation, the Olympics finally arrived in London, whipping the whole nation into a frenzy of Olympic mania and mayhem. The 2012 games were a huge success and even the biggest sceptics seemed to have been won over by the time the closing ceremony came.
Even before the first baton had been passed (or dropped) and the first bike pedal pushed, many Londoners were dreading the two weeks and what it might mean for people trying to work, travel and lead...
Read More
CP Creative Ltd
Forge & Co
I54 – 158 Shoreditch High St
Phone: 0203 637 1440


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tippy toe co.
Perfect for...
Boys and girls (3-25 years old )who love to dance! Our classes encourage motor-active skills, stamina, concentration, musical awareness, flexibility, expression, coordination and creativity.
Founded in 2013, Tippy Toe Co. is Australia's premiere dance and movement program for children, adolecents and young people with additional needs. TTC has taught over 175 students to date, employs 20 specially trained teaching staff, and offers professional development workshops to dance instructors from accross Australia. TTC currently offers the following dance genres and programs:
- Ballet
- Tap
- Jazz
- Hip Hop
- TheraDance
What to expect...
A carefully constructed syllabus that is regularly fine-tuned to fit individual and class requirements. Classes incorporate engaging equipment & music to continuously challenge students.
Programs Descriptions
Focuses on gross-motor skills, balance, posture and grace.
Jazz/Hip Hop
Current pop music and powerful body movements. Up beat and lots of fun!
A sensory based dance style with focus on linking musicality and music.
Building upon the Tippy Toe Co. methodology, head Tippy Toe teacher and Occupational Therapist, Shannon, has developed TheraDance, a one-on-one program to enable students who would benefit from additional behavioural, sensory, social and emotional support. TheraDance compliments Tippy Toe Co.'s inclusive group classes with many of the activities and therapy tools working towards students being able to excel and thrive in a social group environment... Learn more
1 class/week: $225/term
2 classes/week: $400/term
$120/45 min
$30 Tippy Toe Co. shirt (optional)
Term 3: 17 July - 22 Sept (10 wks)
Tuesday: Jazz/Hip Hop
3:45pm, 4:45pm
Thursday: Ballet
3:45pm, 4:45pm
Saturday: All styles!
8am - 5pm


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Here are some tips for you to write the admission essay the tips focus on the while traditionally not part of the law school admissions process, some law. Law school personal statement and admissions tips law school admissions tips from prelaw guru optional law school application essays are only optional if you do. Top 10 tips for successfully writing a law school essay poor application of the law to the facts martin also discusses the hallmarks of a good essay answer. Transform your admission essay from good to great with our help. Tips writing essay about myself remix war against terrorism english essay automated essay scoring online text short essay on defence day of law admissions unb essay.
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What Will Insurance Be Like in Ten Years?
In a mere 3,650 days what can insurance agents expect to be dealing with? Here are some predictions already taking shape.
Smartphones will be totally voice active. Siri will be everywhere. Mr. Spock's communicator from the 1960's TV series Star Trek became a flip phone, which has already been replaced by the smartphone. Almost every product sold from pets to furniture will have a chip identifier so that if stolen, lost or misplaced the object can be located.
Homes will be wired and wireless-equipped with remote, real-time capabilities. Fire, water and theft identifiers in homes will react within seconds to alert the owner, police and medical centers. "I've fallen and I can't get up" will be transmitted automatically. Self-driving cars will be a reality, but there will still be accidents due to human error. State legislators, insurance companies and adjusters, lawyers and agents will have to adjust to legal changes affecting the insurance industry. For the insurance industry, big data, analytic models and predictive modeling will predominate.
Remember: predictions are just that. They are often wrong. For example, remember when we were told that by now we would all be piloting flying cars? Some things are just not good ideas; how could accidents be avoided if billions of cars were all airborne?
Another prediction: Efforts by global financial services firms to turn insurance into just another banking product will all fail, because all risk will always be local.


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The synthesis of a protein such as FMRP (Fragile X ..
Defects in Enzymes
Lysosomal Storage Diseases
Lysosomal enzymes catalyze the breakdown of complex macromolecules.
Autophagy: breakdown of intracellular organelles
Heterophagy: phagocytosis
Synthesis of a catalytcally inactive enzyme but that cross-reacts with immunoassays so normal levels of enzyme are detected.
Defects in post-translational processing of the enzymes (e.g. addition of mannose-6-phosphate "marker": enzyme secreted instead of ending in lysosome)
Lack of an enzyme activator or protector protein
Lack of a substrate activator protein
Lack of a transport protein required for egress of digested material out of lysosome
Long-chain complex proteoglycans abundant in ground substance of connective tissue. All except Hunter's are AR. Progressive disorders characterized by involvement of multiple organs including liver, spleen, heart and blood vessels. Most associated with coarse facial features, clouding of the cornea, joint stiffness and mental retardation, HSM, skeletal deformities, valvular lesions and subendothelial arterial deposits, particularly in coronary arteries. MI impt cause of death.
Hereditary deficiency of one of the enzymes involved in the synthesis or degradation of glycogen.
Hepatic forms:
Myopathic forms: , muscle phosphofructokinase (Type VII)
Deficiency of a-glucosidase (acid maltase):
Brancher glycogenosis: (Type IV) lack of branching enzyme with widespread deposition of abnormal glycogen in brain, heart, skeletal muscle and liver.
Defects in Proteins that Regulate Cell Growth
Multifactorial Inheritance
Hair color, eye color, skin color, height and intelligence.
Diabetes Mellitus, obesity, cleft lip or palate, congenital heart disease, coronary heart disease, hypertension, gout, pyloric stenosis.
The risk of inheriting a multifactorial disorder is greater in sibs of pts. having severe expression of the disorder.
Concordance for identical twins is 20-40%
If one child is affected, 7% risk for next child; if two, 9%.
Normal Karyotype
46 chromosomes. 46,XX female; 46,XY male.
Arrest mitosis in metaphase with colchicine and stain chromosomes. Giemsa stain: G banding. Resolution improved by getting cells in prophase.
p: short arm (petit); q: long arm.
Regions numbered 1,2,3 from centromere outward.
Limits to karyotyping: applicable only to cells that are dividing.
FISH: flouresence labelled probes recognize chromosome-specific sequences, or demonstarte subtle microdeletions.
Euploid. . any exact multiple of haploid.
Aneuploid . chromosome # is not an exact multiple of 23.
Nondisjunction def. homologous pairs of chromosomes fail to disjoin at first meiotic division or the two chromatids fail to separate at either the second meiotic division or at somatic mitotic divisions. This results in two aneuploid cells.
Anaphase lag def. one homologous chromosome is left behind and is excluded from cell nucleus in meiosis or mitosis. This results in one normal cell and in one cell with monosomy.
Mosaicism def. two or more populations of cells in the same individual.
Mosaicism affected the sex chromosomes is fairly common. e.g. 45X/47,XXX mosaic (phenotype: )
Chromosomal breakage: structural change in chromosomes followed by loss or rearrangement of material:
(e.g. , , )
Bench-to-bedside plans for fragile X syndrome are severely limited by the lack of validated outcome measures. The reviewed candidate biomarkers are at early stages of validation and deserve further investigation.
What causes Fragile X Syndrome | Fragile X Association …
A biomarker is a measurable and quantifiable biological characteristic that can serve as an indicator of healthy or pathological processes. For example, HDL and LDL are biomarkers for cardiovascular health and autoantibodies are biomarkers for autoimmune disease. Biomarkers are extremely useful in evaluating the clinical benefit of pharmaceutical interventions. A good biomarker assay will be sensitive, specific, rapid, simple to perform, inexpensive and applicable to easily obtained sample material. There is an urgent need to develop such biomarkers for fragile X syndrome (FXS).


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Waiting for more chromers
by Kirk Portocarrero
Friday morning started off just like the last few days getting a couple of fish in the morning and then having to pick away at them through the mornings we ended up landing 4 kings all adults
Captain Kirk Portocarrero is a full-time, professional fishing guide and outfitter, solely, for 29 years straight, owner & operator of Northern California's SacRiverGuide.com. Kirk started at age 15, in the salmon fishing industry in SF and then migrating to Northern California, with a team of 5 guides working for him. He is on the water at least 300 days a year, and his expertise is like none other, providing top of line guide services and equipment, ensuring a successful day of fishing. Specializing Northern California and Southern Oregon fishing for salmon, trout, and steelhead. Call (800) 670-4448 to get in on the action.
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By: Honey Sweetie Acres
Open Farm Day April 2018April 24, 2018
Here is a little video to remind you of your adventures at our Open House and Farm Store Grand Opening! Honey…Read More
Goat Milk Soap Good for Eczema: Does it Help?March 25, 2018
Is Goat Milk Soap Good for Eczema? What is Eczema? Eczema is patches of rough, reddened, intensely itchy skin can keep…Read More
Cow Milk versus Goat MilkFebruary 15, 2018
We get this question all the time, and I do mean ALL the time. While we obviously believe raw milk is…Read More
Goat Yoga Giveaway!February 13, 2018
Who doesn't love a Goat Yoga Giveaway! Enter to win 2 tickets to one of our 2018 Goat Yoga Classes! Contest…Read More
Protect Paws with our Lotion BarsJanuary 22, 2018
Protect Paws in the Winter This time of year is tough on animals as well as humans. Dogs, Cats and yes…Read More
Are Your Personal Skin Care Products Harming You?January 22, 2018
A Wake-Up Call In the United States, we have a growing epidemic of chronic illness and disease. In the coming year,…Read More
DIY Organic Hair Conditioner RecipeJanuary 1, 2018
Avoid Chemicals with this Organic Hair Conditioner Recipe Since I mentioned this DIY Organic Hair Conditioner recipe in last month's newsletter, I've…Read More
How Does Goat Milk Soap Benefit Skin?November 6, 2017
Skin Benefits of Goat Milk Soap If you are looking for a reason to use goat milk soap, here it is. …Read More
All Goat Milk Soap is Not EqualAugust 8, 2017
When we first started making goat milk soap, it was to benefit our family. We wanted to create a natural alternative…Read More
Fix Your Skin's Expert Roundup on Best Organic Skin Care Tips 2017March 13, 2017
As part of the 200+ expert round up on how to Fix Your Skin, Regina was asked to add her skin…Read More


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Lay the Favorite
- A Memoir of Gambling
- Narrated by: Phoebe Zimmermann
- Length: 8 hrs and 1 min
- Unabridged Audiobook
- Release date: 22-06-10
- Language: English
- Publisher: Random House Audio
Beth Raymer arrived in Las Vegas in 2001, hoping to land a job as a cocktail waitress at one of the big casinos. In the meantime, she lived in a $17-a-night motel with her dog, Otis, and waited tables at a low-rent Thai restaurant. One day, one of her regular customers told her about a job she thought Beth would be perfect for and sent her to see Dink, of Dink Inc. Dink was a professional sports gambler—one of the biggest in Vegas. He was looking for a right-hand man—someone who would show up on time, who had a head for numbers, and who didn't steal. She got the job.
Lay the Favorite is the story of Beth Raymer's years in the high-stakes, high-anxiety world of sports betting—a period that saw the fall of the local bookie and the rise of the freewheeling, unregulated offshore sports book, and with it the elevation of sports betting in popular culture. As the business explodes, Beth rises—from assistant to expert, trusted and seasoned enough to open an offshore booking office in the Caribbean with a few associates, men who leave their families up north to make a quick killing, while donning new tropical personas fueled by abundant drugs and local girlfriends, and who one by one succumb to their vices. They lie, cheat, steal, and run, until Beth is the last man standing.
Beth Raymer is a natural storyteller: funny, charming, and fully awake to the ironies around her. But she is also a keen and compassionate observer of the adrenaline-addicted, rougish types who become her mentors, her enemies, her family. Raymer brings to life a world that teems with pathos and ecstasy in this wild picaresque that also tells the story of a young woman's crazy, sexy, most unlikely coming-of-age.
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By Roy on 23-10-10
A Real Hoot
I ordered Beth Raymer's book because I thought it would give me insight into professaionl gambling (legal and otherwise). Well, I got much more than I bargained for. This is is a very smart and funny book about Beth Raymer's sojourn into various "career fields" of which gambling is just one. Certainly, this is one of the most entertaining books that I have obtained from Audible in some time. You will be seduced into her stories and enticed by the prose. Her character sketches are the best. The book is wonderfully written and the reading of Phoebe Zimmerman hits the mark. I hope that we hear more from Beth Raymer in the near future.
4 of 4 people found this review helpful
By Arthur on 13-08-13
good book but too long
first half is great but second half drags. i am not as interested in her dating life as she is.
1 of 1 people found this review helpful


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