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Tag: Athletic Men
Getting Off
by admin on Feb.15, 2016, under Eurocreme
Caught after his first offence and hauled up before the station master, blond twink Lyle Boyce is given two options, a night in the cells with whoever may be there waiting for him, or do the officer a favour and get home to mummy. Shaken and nervous, super lad Lyle chooses the least worst option and plumps to give the Officer Daddy what he's asking for. Pulled up on the desk, Big T lives up to his name, tall, built and the perfect daddy for Lyle to be taken by! His stiff thick dick shoved down throats and up his peachy white ass, Lyle is fucked hard, leaving paperwork on the floor and rocking the office as his pretty pink hole is plundered deeper and wider than ever before. Laying back and taking his punishment whilst Big T works up a sweat, both of them get off, Lyle more so as he quickly gathers his stuff and runs out, still dripping with daddy's hot spunk!
Back Behind Bars
by admin on Feb.08, 2016, under Eurocreme
Looks can be deceiving as angel-faced Johannes Lars finds himself back behind bars. We don't know what this young tearaway has been up to, but the reason he got himself arrested and sent down becomes very clear when duty officer Letterio Amadeo bangs on the bars. Curiously pleased to see him back In the cell, the dark brooding officer beckons his captive over and greets him with his almighty bulge right at face level. No wonder Johannes seems to be getting caught all the time! With a dick like Letterio's waiting for attention, Johannes swiftly guzzles the thick curved dick down his slim white neck, all for the pleasure of Letterio who verbally instructs the boy into what he's doing. Letterio wants more, and Johannes knows that a hard fucking is about to occur when he enters the cell! Stripping both butt naked, the hairy muscled frame of the office dwarfs the petty criminal, and his shaft stretched the tight hole wide and sloppy as our brute top fucks him hard and fast, getting soaked with sweat and covering Johannes with it as he's gripped and pulled back onto his stiff dick. Having had his way, Letterio lets the boy shoot, and boy does he shoot, swiftly joined by a dumped load as Letterio stands over him, leaving him to clear himself up ready for next time.

Recruit Wanking
by admin on Jan.25, 2016, under Eurocreme
Catching the last of the days sunshine, older recruits Logan Moore and Nathan Hope hide from the sergeant at the back of the bushes, sneaking off from the chores of boot polishing and bunk duty. Using their time to enjoy a quick wank with each other, hairy chested Logan, his blond hair glistening in the sun looking sexy as hell, next to Nathan Hope's gorgeous dark features and smooth tattooed skin. Nathan can't get enough of his mates dick, watching him wank, as he himself strokes his long handsome shaft. Laying back and covering their eyes from the sun, this doesn't stop them continuing to stroke themselves as Logan wants a bit more than that and moves back to grab Nathan's stiffening dick in his strong hand. Crossing arms to jerk each other in unison, the youthful torso of Nathan next to the manly muscular Logan is a perfect sight, and as the camera pans down to their rock hard dicks, it's enough to make us all shoot. As these men empty their balls all over their uniform, they realise they have to now scrub them clean before the sergeants sees them, but it was all well worth it!
Taking Confession
by admin on Sep.21, 2015, under Eurocreme
Taking confession is really spiritual rite, and when hunky priest Jessy Ares sees his favourite choir boy sneaking in to hear some guilty confessions, there's only one punishment to be given…and it's one that is kept purely in the confessional booth itself! Ushering the naughty confessor out, Jessy and Danny Montero are left alone. Jessy unzips his trousers as he towers over the olive skinned beauty, whipping his cock out and presenting it to his boy! Taking the cue, Danny takes the length into his mouth and pleasures his priest perfectly. Father Jessy isn't fully convinced Danny has learnt his lesson though, and proceeds to prop his young smooth body up against him, ass to his face and spreads those peachy cheeks, allowing him — and us — unrivalled access to his pink hole, twitching in anticipation for his penance to be given! Jessy fucks Danny so hard the confessional booth rocks, almost giving the whole game away. Luckily, the spunk flies before the walls collapse, leaving Danny's chest and shoulders dripping, and with one final instruction from Jessy, Danny is let off the hook!
Caught by the Priest
by admin on Sep.14, 2015, under Eurocreme
The best excuse for a cheeky wank in the storage room is 'Looking for a Bible.' However, super hung priest Craig Daniel catches horny young man Johny in the act and what he's jerking over definitely isn't a Bible…it's a porno! Catching sight of the hung boys Johny Cruz is getting off to, Craig decides the right punishment for this cock hungry twink is one hell of a real dick, all 9" of it being gobbled down his throat. Soon rock hard and eager for more, Craig's giant dick has its eye on Johny's delicious ass, and as Johny is propped up against the shelving, his cheeks are spread open, exposing the puckering hole, getting wetter with each lap by the priest, ready and desperate of the big thick dick to slide inside! Slamming away again and again, Johny pushes back, taking his punishment as hard as he can, and Craig is more than happy to dish it out for as long as possible, ending up covering his boy in holy semen!
Big Dick Pick-Up
by admin on Jun.22, 2015, under Eurocreme
Back from a night out, Kayden stumbles in the front door and it looks like he's pulled! Dragging the tall young Luke Vogel downstairs to his bedroom, they are both horny as fuck and can't wait to start stripping each other, exposing their both huge dicks which are swiftly swallowed and lapped at until rock solid! As Kayden face fucks the handsome Luke, his throat is stretched by his thick meat and the dribble runs down his shaft to his heavy balls, about to burst with spunk! Flipping Luke on his front and pulling his hips high, his delicious ass is eaten deep, letting us watch as the pink hole puckers and opens for his hot tongue and soon to be dick! Fucking his trade doggy style, Kayden's leg muscles are put to the test as he advances, and straddles that ass, pushing his dick down and inside over and over and gives us a view we could only dream about as the huge dick stretches Luke's virginal hole, letting us see every inch slide and pump from tip to hilt again and again, Kayden fucking him balls deep! Luke can't take much more and when Kayden jerks him off, his shoots his load whilst still getting fucked and Kayden finishes the night with a powerful spunking all over his new found fuck-mate!
First Time Cam Show
by admin on Jun.08, 2015, under Eurocreme
Chilling out with Kayden, we're waiting on his bed with him until his sexy young friend arrives before a fun night out in London's Soho. Drew soon knocks on the door and jumps in and joins us on the bed with star Kayden and we get talking about what he does, and it turns very sexy very quickly! Showing us his cam-site profile, it's piqued Kayden's interest, especially all those sexy boys online showing themselves off for their audience! Keen to experiment and have a go for himself, Drew and Kayden move the laptop aside, making sure the camera's always on them as they kiss heavily, deep and with plenty of tongue! Kayden as always is hungry for dick, and beautiful young Drew's dick is top of his agenda, filling his face full of it as it grows against his tongue, getting it juicy enough to move to his ass, lapping at it like a thirsty puppy! Drew moans in ecstasy and Kayden's humungous cock is throbbing for ass! Shoving it deep inside his fuck-mate all whilst we're gifted the pleasure of watching them get sweaty together, how much we wish we were the ones in the room! We can almost always tell when Kayden's getting ready to shoot, the bottom is bent double, ass in the air, the pace quickens and his muscles flex in smooth rhythm and we're given the huge wads of spunk covering Drew, hitting him from chin to balls, and everywhere else too!
Cruising the Park
by admin on Jun.01, 2015, under Eurocreme
Invited on his morning run, we love watching this young muscular stud jog in the park, and when he chats to us about someone he's been cruising, we knows it's about to get even hotter! As cute blond Kamyk plucks up the courage and comes over, they, the cameraman and us follow them back to Kayden's for a 'coffee' and it's exactly what we want to happen! Moving swiftly on to the bed, Kamyk is stripped, his smooth pale body looking damn fine next to Kayden's muscular frame, his pecs, abs and giant dick is heaven to watch, and when it's bursting from Kamyk's cheeks as he swallows as much as he can, wow! His ass more than makes up for where his throat was too tight, and Kayden doesn't hold back as he slams in and out over and over, the post-workout adrenaline coursing through his veins, giving him more power than we've seen before, just wait for his cumshot, it'll take your eye out!
Horny Son, Happy Daddy
by admin on May.11, 2015, under Eurocreme
True Essex lad Jack is a hot new face on the porn scene and with his great energy tells us what he loves about getting a real man to power-fuck him until he shoots! With such a young lad on the books, the only guy to fix him up with had to be superstar Dirk Caber, only a pro like him can handle such a boundless spirit like Jack and keep up with him! Pushed to his knees and sucking on Dirk's proud meat, Jack's own big dick is visibly bouncing as he gets throat fucked by our hairy muscle brute. Moving on once Daddy has had enough of tickling tonsils, Jack's rear is brought high and played with at Dirk's leisure until he can tell he's ready for his dick to enter him hard and fast! Flipped, lifted and fucked over and over, Jack's initiation is complete once Dirk empties his bursting balls all over his twink, as his load is joined by the already empty Jack!
Daddy Wants You!
by admin on Apr.27, 2015, under Eurocreme
Daddy Craig, hairy chested and sporting a sexy beard just can't get enough of the cute young twinks he adores. Skinny young slice Sky James is his perfect type, and Craig's big dick jumps at the chance to get his way with the young lad! As Craig owns this boy right there on the bed, it's not just Daddy who wants this, as horny Sky is drawn by the musky scent of a real man, one who he knows is going to satisfy his almost unquenchable thirst for giant dick inside him!


text: Home > Overseas China launches new cruise ship tour in South China Sea Reuters Posted at Mar 03 2017 11:22 AM Share Save Facebook Twitter GPlus LinkedIn BEIJING - A new Chinese cruise ship has embarked on its maiden voyage to the disputed Paracel Islands in the South China Sea, state news agency Xinhua said on Friday, the latest effort by Beijing to bolster its claims in the strategic waterway. The Changle Princess sailed from Sanya on the southern Chinese island province of Hainan on Thursday afternoon with 308 passengers on a four-day voyage, Xinhua said. The new ship can carry 499 people and has 82 guest rooms with dining, entertainment, shopping, medical and postal services on board, it added. Tourists will be able to visit the three islands in the Crescent group of the Paracels, Xinhua said. China has previously said it plans to build hotels, villas and shops on the Crescent group and has also said it wants to build Maldives-style resorts around the South China Sea, though it is unclear if foreigners will ever be allowed to visit. China claims 90 percent of the potentially energy-rich South China Sea. Brunei, Malaysia, the Philippines, Vietnam and Taiwan lay claim to parts of the sea, through which passes about $5 trillion of trade a year. Countries competing to cement their rival claims have encouraged a growing civilian presence on disputed islands in the South China Sea. The first cruises from China to the Paracel islands were launched by Hainan Strait Shipping Co in 2013. The Paracels are also claimed by Vietnam and Taiwan. Share Save Facebook Share on Twitter GPlus LinkedIn Read More: south china sea paracel islands beijing reclamation hainan Changle Princess /news/02/24/17/ph-urged-to-insist-hague-ruling-as-basis-for-south-china-sea-code-of-conduct/video/news/02/28/17/time-to-lower-expectations-on-code-of-conduct-in-south-china-sea-expert/overseas/02/23/17/china-military-says-aware-of-us-carrier-in-south-china-sea/overseas/03/02/17/taiwan-navy-air-force-to-train-in-s-china-sea-due-to-growing-security-threat/overseas/03/02/17/is-beijing-outflanking-the-us-in-the-south-china-sea

subset: commoncrawl


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Delicate and elegant, with a nose of crushed flowers and bright red fruit, this could almost be Chambolle. William Downie is one of the New World's most elegant winemakers, and this is one of his benchmark wines. The 2016 is so pure and elegant, with wonderful precision on the finish. Bravo.
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Published: 03.01.2017
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Three Sessions with Joel
What a great visit from Joel Barron. It was great to hang out with him for the first time in seven years. For me, an "old guy" whose obsession with surfing began later in life, it's especially gratifying to have old friends who have also come to share my passion. Thanks, Joel, for taking the time to leave your perfect and warm California waves for our choppy cold business.
Surfing 16 (7/6): Junky Running — Tuesday AM at Indian Beach
For our second session I took Joel to Indian Beach on Tuesday morning, close to high tide again. The conditions were not perfect, as the wind had started to come up. But there was some fun riding to be had. After paddling in along the customary route on the north end, we had to move pretty far south to find the breaking peaks. But the 4-5 foot waves were completely inconsistent in their breaking pattern, and we soon got tired chasing after the breaking peaks in the middle. Those several times we got caught inside forced us to battle back out through the beach break, spending precious energy. It was hard to wind up in the right place, along a breaking corner or wedge of the steep waves. On days like this, you have to have perfect timing and position unless you want to get pounded by the central, close-out section of the wave, or miss it altogether. For me this happened a few times, though, before the end, and I can say it was pretty fun. We surfed for about 90 minutes.
Surfing 17 (7/6): More Shape than Substance — Tuesday PM at Oswald
Tuesday afternoon, the weather could not have been more sunny and beautiful (or so we thought until we got to Wednesday!). We played on the beach and bided our time until the evening, and then we went back to Oswald. It was a blast to be back there for an evening session on a second day in a row. It was smaller, and, if anything, smoother and glassier than the first night. We went into the middle, and chased a bunch of waves, catching a few. The shape was brilliant, and the beauty of the moment was extreme. But the size was small, and the waves failed to set up fully where they would have produced a really exciting ride. Most breaks had multiple breaking humps and quickly closed out. And there were a lot of people out. So we got our selves tuckered out. At the end of the session we again paddled down to the south end and I found that the same conditions applied as the previous night. The south end was more choppy, but also bigger, steeper, and, once you had found your position, better surfing overall. So the night ended up with quite a few exciting and gratifying rides.
Surfing 18 (7/7): Sunny North End Playtime — Wednesday AM at Oswald
Twelve hours later we again hiked down to Short Sand, starting to really feel the pain from pushing our 40+ year old bodies as we had been doing. Wednesday would shape up into a really gorgeous day. It was super hot by mid morning, over 75 degrees on the beach, and everybody was out and sunbathing or setting up for a full day of fun at Smuggler Cove. The waves, such as they were (kinda junky and disorganized, and small, but pretty glassy in spite of 10 knot winds, because the wind was ENE) ended up being crowded by thrill seekers. We went north on the beach to suit up, and ended up paddling all the way north. We did find some ridable waves but the conditions, aside from the weather, weren't the best. We had fun chasing those waves but both complained of lacking full strength for paddling, etc.
Not-Surfing (7/8): Too Sore, Too Tired, Too Picky — Thursday AM Non-Session at Indian Beach
Thursday morning we were dragging. And the weather, after such a beautiful day on Wednesday, seemed grim and foreboding. We nevertheless motivated ourselves to get up and drive to Indian Beach. Once there, our sore and tired bodies spoke much more loudly than the feeble stoke in our hearts. Looking out, nothing about the surfing appealed to us. The tide was semi-out. Slate sky. Water ashen clay and splashed with foam. Nobody surfing, but two guys just finishing up. We watched for a while and talked about all the reasons not to surf it. The wind chop was as big as the waves, which looked to be 2-3 feet at max. Together, wind and swell turned the beach break into swirling froth of barely surfable closeouts. We were so sore (and I would become more and more sore over the next several days). And so tired. So we went to Pig N' Pancake in Cannon Beach instead and talked about how good the waves are in California, and why.
Next time, I'll come visit you, Joel!


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XPEL Headlight Protection Part #H0202 Customer Reviews
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Reviewed by Debbie O (Rockton, IL) — Apr 13, 2017 3:38 PM
We have this on every car. The most recent is a 2000 Honda Accord. It's not easy to apply, but it stops the yellowing of headlights. We had a 1995 Acura Integra that had cracks in the headlights that would let water in and when the water hit the halogen bulb it would destroy the bulb. X-Pel plastic solved that problem. No more water got into the lights.
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Orthophytum benzingiiOut of Stock
A strange species from Minas Gerais that looks more like an inflorescence than a plant. Short, succulent, triangular leaves grow singly in a whorl up a tall stem, spaced a half inch to an inch apart. When it blooms, tight clusters of short branches and white flowers form at the top.
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- Indirect Sun
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- Dry
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- Winter
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by Ryan Snyder
Walrus joins Boston funk and soul outfit Cosmodrome Wednesday night at the Blind Tiger, while Ten 0 One has the hump day honky tonk with the Grand Ole Uproar.
Snuzz and Sam Frazier paint rock by the Numbers with Jack Carter & the Armory and Emily Stewart & the Baby Teeth at the Blind Tiger on Thursday. Multi-instrumental folk duo the Driftwood Singers join power-pop band TV Yellow Bull City bluesman TA James at the Green Bean, while alt-rockers Sole Citizen play a free one in the tavern at Ziggy's.
Pop goes Greene Street Club with Jonas Sees In Color, Luna Arcade, Kitchen Sink Fiasco, Nice To Meet You James and Capital Boulevard on Friday. Cosmic Charlie do the Dead at the Blind Tiger, not in that way. Sean Mettler and Khiana Meyer play a SoundLizzard Productions songwriter showcase at the Garage. Black Lodge brings rockers the Piedmontsmen with picker Marcus Hodges and Drag Sounds side project Pistol Crash. Ziggy's has a country throwdown with Old Southern Moonshine Revival and Jody Lee Petty, while Virginia piano-pop outfit Melodime let their website get taken over by grey-market Viagra peddlers, but we'll still mention they're at the Green Bean with Colorado rock and folk duo Statue of Liberty and GT & Misti.
The Garage so horn-y on Saturday with a WalkerFest tune-up featuring the Brand New Life and Orquesta Gardel. Johnny & June's hosts country-soul songbird Emma King & the Heartsets, while blues powerhouse Big Ron Hunter plays Summer on Trade. The Blind Tiger has blues of their own with the Allison King Band and Mike Edwards & the Banned. Charleston picker Laura Thurston plays the Green Bean with Alan Peterson and the super mellow Dylan Holton.
The great Robert Earl Keen comes to us via Ziggy's on Sunday. The Blind Tiger hosts a benefit for the Guilford County Animal Shelter featuring nine bands that are only TBA as of press time. There's a fairly rare electronic show, albeit of a compositional nature, at the Green Bean with ambient group Lost Trail with Tesla Recoils and loop master Kluski Zoupa.
On Tuesday, Raleigh folk-rock band Inner City Mountain Men visit the Blind Tiger, while few bands deserve to be described as truly, unrepentantly awful, but the shoe fits Saving Abel. They're at Ziggy's.


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Xenobiotic metabolism and disposition in human lung cell models: comparison with in vivo expression profiles.Numerous lung cell lines are currently used as in vitro models for pharmacological and toxicological studies. However, no exhaustive report about the metabolic capacities of these models in comparison with those of lung tissues is available. In the present study, we used a high-throughput quantitative real-time reverse transcription-polymerase chain reaction strategy to characterize the expression profiles of 380 genes encoding proteins involved in the metabolism and disposition of xenobiotics in 10 commonly used lung cell lines (A549, H292, H358, H460, H727, Calu-1, 16HBE, 1 HAEO, BEAS-2B, and L-132) and four primary cultures of human bronchial epithelial cells. Expression results were then compared with those previously obtained in human nontumoral and tumoral lung tissues. Our results revealed disparities in gene expression between lung cell lines or when comparing lung cell lines with primary cells or lung tissues. Primary cell cultures displayed the highest similarities with bronchial mucosa in terms of transcript profiling and therefore seem to be the most relevant in vitro model for investigating the metabolism and bioactivation of toxicants and drugs in bronchial epithelium. H292 and BEAS-2B cell lines, which exhibited the highest homology in gene expression pattern with primary cells and the lowest number of dysregulated genes compared with nontumoral lung tissues, could be used as surrogates for toxicological and pharmacological studies. Overall, our study should provide references for researchers to choose the most appropriate in vitro model for analyzing the cellular effects of drugs or airborne toxicants on the airway.[1]
- Xenobiotic metabolism and disposition in human lung cell models: comparison with in vivo expression profiles. Courcot, E., Leclerc, J., Lafitte, J.J., Mensier, E., Jaillard, S., Gosset, P., Shirali, P., Pottier, N., Broly, F., Lo-Guidice, J.M. Drug Metab. Dispos. (2012) [Pubmed]
Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg


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Create a new character, and start a game with both characters.Making a jailbreak lets apple know that they are not as secure as they think they are.When you stay behind Terramorphous, he will not be able to attack you.Once your inventory is full, switch your currently equipped class mod for another one in your inventory (you can then re-equip your original class mod after you have done this).
It is recommended if you do this in solo mode that you use a Level 50 Gunzerker with two rocket launchers equipped while in Gunzerk mode.How to hack and get rare stuff from the slot machines in Borderlands 2. This way I don't have to worry about a cheat player affecting my flow.Travel up to the cliff and jump off, and you will be able to see it near the water and another small cluster of buildings below.Normally they have a policy that states such actions are illegal.To easily do this, have two players keep activating a trade with each other while standing next to each other.
Once you reach an area with multiple objects that you can interact with, you must interact with each item a certain number of times in a specific order.Borderlands 2 Slot Machine Hack mediafire links free. BORDERLANDS 2 UNLIMITED GOLDEN KEYS GLITCH PC,XBOX,PS3 2012 TODAY. borderlands 2 trainer cheat hack,.High-Flying Hurler: Killed a flying enemy with a thrown Tediore weapon.Once you kill Flesh Stick, just go back to Tiny Tina, and restart the quest.Bitch - BNK3R, The Bunker (Mission: Where Angels Fear To Tread).Drop down to this area to reach the entrance to Caustic Caverns.Build Buster: Killed a Constructor without it ever building another bot.However, if you just kill him, you will get a large amount of XP, depending on what level you are (level appropriate on the first playthrough is between 1,800-3,000 XP per kill, and the second playthrough is between 2,000-4,500 XP per kill).
You will discover this area automatically by following the story missions.The Sham - BNK3R, The Bunker (Mission: Where Angels Fear To Tread).Then, go straight, jump over the two cube blocks, and immediately turn left to enter a cave with a bunch of Minecraft blocks.Turn the wheel two times, press the button on the TV three times, pull the switch on the ground three times, and then pull the lever on the wall to the right of the switch on the ground three times.Whenever you open a box in The Dust, there is a small chance you will get this special Easter Egg.Repeat this for approximately an hour to get the new character to Level 50.
Each has their own ninja weapon, are color-coordinated, and named after classical Italian painters.The best place to get cheats, codes, cheat codes, walkthrough, guide, FAQ, unlockables, tricks, and secrets for Borderlands for PC.To unlock the following, you have to play the game and collect/Earn achievements. You can find those earned achievemen., Borderlands 2 for the PC.
At the edge of the cliff, look down, and you should see a tent.GameStop: Buy Borderlands 2, 2K Games, Xbox 360,. loc_en_US, sid_92826, prod,. And you thought the original Borderlands had a ton of loot!.borderlands 2 slot machine orange weapons glitch still work? < > Showing 1-15 of 16 comments Valkari. Jan 9, 2014 @ 12. Why use a glitch to cheat?.When he comes out of the ground, quickly throw a bunch of slag grenades, and attack him with your strongest weapons.
It is also possible to get some of these items from other enemies in the game.How do I set my level, unlocked weapon equip slots and playthrough mode?. I would also like to have all weapon slots. With Gibbed's Borderlands 2 Save Game.Go to any slot machine after the game has recently been auto saved.
To easily do this, have two players unequip any mods and shield from their character.Borderlands 2 for Xbox 360 cheats. If you have a save file for Borderlands 1 while playing Borderlands 2. More and more strong updates to the site for PC,.
Nasty Surprise - Vermivorous the Invincible, Tundra Express and Caustic Caverns.Each time you open the chest, it will use one key and give you rare weapon(s) or item(s) that are scaled to the current level you are at when you open the chest.
Thus, it can take a very long time to get them to drop the desired item.Blight Explorer: Discovered all named locations in Eridium Blight, Arid Nexus, and Sawtooth Cauldron.Note: It is recommended you do not attempt this until you at least reach Level 15.Totem 1: It is in the far southern corner of the Grotto, in the slightly more narrow passage with lots of native wall paintings.


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The Ussr Train Station Suitcase Retro Vintage
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Enough has been written about Kate Middleton's extensive beauty routine. From her favorite Bobbi Brown makeup to her cult classic blowouts (even straight out of the delivery room!), the $35,000+ annual maintenance costs add up to a lot of primping – and now she has to change just about all of it ... Read More about What's in Kate Middleton's post-baby beauty kit? And why we all need to stock up, kiddo or not
Discovering Queen Elizabeth (and Duchess Kate's) Britain, one beauty recipe at a time!
So, did Queen Elizabeth wake up on her 92nd birthday and have a nice laugh at Prince Charles' expense? Hoo boy, doesn't seem you're going to be the king anytime in the near future. After all, the world's oldest monarch isn't going anywhere soon, considering her sprightly step and reigns-well-in-hand ... Read More about Discovering Queen Elizabeth (and Duchess Kate's) Britain, one beauty recipe at a time!
June Beauty Must Haves: Things You Need to Own this Month
With the hundreds of beauty products launching every month, it's not easy knowing exactly which skin serum, nail polish or perfume you should spend your hard-earned cash on. Let me take the guesswork out of beauty shopping for you with a short list of The-Beauty-Gypsy-approved ... Read More about June Beauty Must Haves: Things You Need to Own this Month
WATCH: Prince William finds his (very awkward) dancing feet!
I never pegged myself as a royal watcher but this is just soooooo adorable... I might actually feel pity for Prince William if I wasn't laughing so hard! Seems like the royal duo's descent into casual attire encouraged the locals' of Tuvalu, a Polynesian island that's north of Fiji, to ... Read More about WATCH: Prince William finds his (very awkward) dancing feet!
The side-effects of being Kate Middleton
They say that those who live by the media, die by the media. But is it fair for the gutter press to splash topless photos of any woman – whether or not she is queen-in-waiting Kate Middleton – while she is sunbathing in a private chateau on a personal holiday with her legally wedded husband? What do ... Read More about The side-effects of being Kate Middleton


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Bottom line: $2400


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If you lust over the kind of best color for kitchens. We collect really great pictures to add your insight, maybe you will agree that these are very interesting photographs. Okay, you can make similar like them. These best kitchen colors, Conventional kitchen color planning says earthy colors warm neutrals bright tend make both cook diners feel more comfortable these satisfy many purposes coordinating cabinets reflecting light providing.
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Many seniors who need long-term care are able to live safely at home with some outside assistance. Most long-term care services are provided informally by family and friends. Such assistance can be as limited as home-delivered meals or a ride to the grocery store.
Even folks with severe impairments can maintain themselves in their homes and avoid institutionalization if they receive adequate in-home-services, especially if they have a spouse or family members living with or near them to help coordinate the care plan.
"Home-and-community-based services" are personal care services that keep you at home rather than in a residential care facility. Such services could include:
— Companion services: intermittent or round the clock support, encouragement and companionship.
— Housekeeping: laundry and cleaning.
— Personal care attendant: dressing, toileting, bathing, eating.
— Transportation: medical appointments, shopping.
— Meal preparation: meals-on-wheels, pre-made meals.
— Bill paying and other financial management.
— Shopping assistance
— Case management
Payment options for in-home services can include:
— You pay for any care you need out of pocket, from savings, monthly income or the sale of assets
— You have insurance coverage for in-home long-term care
n You are eligible for a needs based public benefit such as: Veterans Administration Assistance to veterans or spouses who qualify. Medicaid which provides in-home assistance to low income Kansans who have exhausted their own resources and the Kansas Senior Care Act provides assistance on a sliding fee scale depending upon the applicant's income and assets.
Who and how do I hire to provide care for me in my home? Anyone you choose, but choose wisely. Here is a list of questions to help you think through the decision:
— If you hire a friend or family member, how will you pay them? If you pay cash, you are potentially liable for payroll taxes including state and federal withholding and other employer's contributions.
— There are 'private duty' organizations available to meet the needs for in-home care. What method of screening does the organization use to insure your safety?
— What happens if your in-home care provider doesn't show up? Do you (or the private duty organization) have a backup plan?
— Do your in-home providers have access to your credit cards, identification, or financial records? What safeguards do you have in place to protect your financial records?
— Who has oversight authority? Other than you, who is supervising and coordinating your in-home plan, keeping you safe and protecting you against financial exploitation, neglect, or abuse?
— Who would make decisions about health care if I'm too sick or disable to act for myself? That can be a difficult problem because your spouse, your family, and your friends do not have the legal authority to make decisions for you unless you have appointed them or a court has appointed a decision maker for you. If you cannot make your own decisions, you'll need an agent or guardian to make those decisions for you.
Information for this article was found in a legal guide for consumers of long-term care in Kansas, "The Law of Care-No Matter Where."
The McPherson County Council on Aging is located at 926 N. Main St., Suite B, in McPherson.


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Do my essay reviews master thesis groupon phd dissertation assistance dissertation online search. The team sitting around the table at groupon's chicago headquarters in the early spring of 2011 were some of the brightest minds in technology and business. The market is gradually warming to groupon inc (nasdaq: grpn), which boasted a positive back half to 2017 the firm won an upgrade wednesday from goldman. Search the world's information, including webpages, images, videos and more google has many special features to help you find exactly what you're looking for.
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2018. Student


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University of Pittsburgh
Approval Date: May 20th, 2011
Grant to Human Engineering Research Lab (HERL) to develop and pilot test a model for increasing the mobility of people with disabilities in Mexico. HERL will offer expertise in wheelchair services, including technical quality and service provision models to ensure wheelchairs are provided appropriately to disabled individuals. This grant is part of the 4R Mobility pilot among partner institutions wheelchairs to design for longer term mobility. $42,662.


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This invention relates to novel base precursors which release a basic component by thermal decomposition.
Stability is of importance, with base precursors which can be put into practical use. Hence, great importance is attached to those base precursors which are stable and neutral at ordinary temperatures and which release a base only when heated. For example, stable compounds like urea are being used as described in U.S. Pat. No. 2,732,299, Belgian Pat. No. 625,554, etc.
Further, a technique of using urea of the ammonium salt of a weak acid (Japanese Pat. Publication No. 1699/65), a technique of using hexamethylenetetramine or semicarbazide (U.S. Pat. No. 3,157,503), a technique of using alkylamines, allylamines, etc. (Japanese Pat. Publication No. 8141/65), and the like, are known.
In addition, a technique of using hydrophobic guanidine derivatives (Japanese Patent Application (OPI) No. 45094/82) (The term "OPI" as used herein refers to a "published unexamined Japanese Patent Application") and a technique of using triazine compounds and carboxylic acids (U.S. Pat. No. 3,493,374) are also known.
Japanese Pat. Publication No. 18704/64 describes a technique of coating an acidic substance on soluble base particles, West German Pat. No. 119,516 describes a technique of encapsulating with wax, Japanese Pat. Publication No. 34792/64 and U.S. Pat. No. 3,284,201 describe a technique of forming a protective layer or an interlayer of a high molecular weight substance, Japanese Pat. Publication Nos. 2145/66, 2146/66, and 15466/66 describe a technique of forming a light-sensitive layer by dispersing in a binder using an organic solvent, and U.S. Pat. Nos. 3,653,091, 3,255,011, 3,294,534, 3,298,834 and 3,301,679, and French Pat. No. 1,405,427 describe a technique of using thermally decomposable acids.
Although various techniques as described above have been proposed, excellent techniques have not yet been attained. Because, light-sensitive materials using this type of compound capable of producing a base upon heating have poor preservability and fail to produce sufficient base upon being heated, thus failing to provide high image density. Further, thermal decomposition products such as colored products (e.g., tar) and white crystals are produced.
An object of the present invention is to provide novel compounds which remove the defects present in conventional base precursors, that is, to provide novel base precursors which are stable at ordinary temperature and, when heated to temperatures higher than a certain temperature, rapidly release a basic substance.
The above-described object of the present invention has been attained by the base precursors represented by the following general formula (A) or (B): ##STR3## wherein A1, A2, A5, A6, A7, and A8 each represents a hydrogen atom, an alkyl group, a substituted alkyl group, a cycloalkyl group, an alkenyl group, an aralkyl group, an aryl group, a substituted aryl group, an acyl group or a heterocyclic group, and A1 and A2 can combine to form a 5- or 6-membered aromatic ring or a 5- or 6-membered heterocyclic group containing an oxygen atom, a sulfur atom or a nitrogen atom and, further, two of A5, A6, A7, and A8 can combine to form a ring, e.g., a cycloaliphatic ring such as a cyclohexyl group, etc., A3 and A4 each represents a hydrogen atom, an alkyl group, a substituted alkyl group, a cycloalkyl group or an aralkyl group, and A3 and A4 can combine to form a ring or A3 and A4 can be a double bond forming an imino group from ##STR4## and X represents a nucleophilic group.
Examples of alkyl groups for the compounds of this invention include a straight or branched chain alkyl group containing 1 to 18 carbon atoms, e.g., a methyl group, etc., and examples of substituents for the substituted alkyl groups for A1 to A8 include a hydroxy group, an alkoxy group, a cyano group, a carboxyl group, a carboalkoxy group, a carbamoyl group, a halogen atom, (e.g., chlorine, etc.) etc.
Examples of cycloalkyl groups include 5- to 6-membered cycloalkyl groups containing 5 to 10 carbon atoms, e.g., a cyclohexyl group, etc., and examples of alkenyl groups include an alkenyl group containing 2 to 10 carbon atoms, e.g., an allyl group, a crotyl group, a cinnamyl group, a vinyl group, etc.
Examples of aralkyl groups include an aralkyl group containing 7 to 10 carbon atoms, e.g., a benzyl group, a β-phenethyl group, a benzhydryl group, etc., examples of aryl groups include a monocyclic or bicyclic group containing 5 to 15 carbon atoms, e.g., a phenyl group, a naphthyl group, an anthryl group, etc., and examples of substituents for the substituted aryl groups include an alkyl group, an alkoxy group, a dialkylamino group, a cyano group, a nitro group, a halogen atom, etc. Examples of heterocyclic groups include 5 to 7 membered group containing one or more of a N atom, a S atom and a O atom as hetero atoms, e.g., a pyridyl group, a furyl group, a thienyl group, a pyrrole group, an indolyl group, etc., and examples of acyl groups include acyl groups containing 2 to 18 carbon atoms which are derived from aliphatic or aromatic carboxylic acids, e.g., an acetyl group, etc. Examples of rings formed when A3 and A4 combine to form a ring include ##STR5## and examples where the group ##STR6## represents an imino group include ##STR7##
Suitable nucleophilic groups represented by X are, for example, a hydroxy group, a hydroxymethyl group, an amino group, a substituted amino group, an aminomethyl group, a substituted aminomethyl group, a mercapto group, a mercaptomethyl group, a carboxyl group, a carbamoyl group, a substituted carbamoyl group, a sulfamoyl group, a substituted sulfamoyl group, etc.
Of the base precursors represented by the above general formulae, compounds of general formula (A) are preferred, with compounds of general formula (A) wherein A1 and A2 form an aromatic or heterocyclic ring being more preferred. Particularly, the most preferred compounds are represented by following general formula (C): ##STR8## wherein G represents a nuclophilic group, preferably --NHR (R: a hydrogen atom, an alkyl group containing 1 to 6 carbon atoms), --OH, --SH, and --COOH, more preferably --OH; R represents a substituent selected from the group consisting of an alkyl group, a substituted alkyl group, a cycloalkyl group, an alkenyl group, an aralkyl group, an aryl group, a hydroxy group, an alkoxy group, a substituted alkoxy group, an amino group, a substituted amino group, an acylamino group, a sulfonylamino group, an acyl group, a nitro group, a cyano group, a halogen atom, an aryloxy group, a carbamoyl group, a substituted carbamoyl group, a sulfamoyl group, and a substituted sulfamoyl group; and n represents an integer of 0 to 4.
When heated, the base precursors of the present invention undergo a Lossen rearrangement and a base is released. Taking salicylhydroxamic acid carbamate, for instance, the decomposition reaction is shown by the following schematic: ##STR9##
Losses rearrangement of hydroxamic acid derivatives generally gives isocyanates as products but, where amines are concurrently produced, the two react with each other to produce urea derivatives. Therefore, production of the urea derivative must be depressed to obtain base precursors which can be practically used.
A characteristic feature of the base precursor of the present invention is the presence of a nucleophilic group in the β-position with respect to the carbonyl group of the hydroxamic acid. This nucleophilic group functions for the isocyanate group produced by the Lossen rearrangement so that an intermolecular nucleophilic attack takes place rapidly with reactivity being lost, thus the produced amine effectively functioning as a base.
The base precursor of the present invention does not undergo a reverse reaction in spite of the presence of the amine near the reaction system. Hence they are effective for thermally developable photographic light-sensitive materials which are to be developed by heating in the absence of a water solvent.
Specific preferred examples of base precursors of the present invention are illustrated below. ##STR10##
The compounds of the present invention shown above are illustrative and the invention should not be construed as being limited to the above-illustrated compounds.
Examples of the synthesis of base precursors of the present invention are described below.
The general synthesis process is as follows:
A carboxylic acid having a nucleophilic group, X, in the β-position is used as a starting material and, after esterification in a conventional manner, the resulting ester is reacted with hydroxylamine to obtain a hydroxamic acid derivative. Then, the sodium salt thereof is reacted with carbamyl chloride derivative in an aprotic polar solvent such as acetonitrile, tetrahydrofuran, etc., or the hydroxamic acid derivative is condensed with carbamyl chloride derivative in the presence of a suitable base such as triethylamine, pyridine, etc., to obtain the intended carbamate in high yield.
Where the nucleophilic group, X, can react with an ester group, a hydroxamic acid group or with carbamyl chloride during the esterification, hydroxamation or the final carbamation, which would lead to reduction in the yield of the desired end product, previous protection of X using a protective group removable under mild conditions, such as a trimethylsilyl group, a methoxyethoxymethyl group, a benzyl group or the like, and an appropriate removal of the protective group after the reactions provides the ability to obtain the end product in good yield.
Specific synthesis examples are described below. In the examples given hereafter unless otherwise indicated, all parts, percents, ratios and the like are by weight.
14 ml of triethylamine was gradually added to a dimethylformamide solution containing 15.3 g of salicylhydroxamic acid and 10 ml of N,N-dimethylcarbamyl fluoride, followed by stirring for ten hours. The reaction solution was poured into a weakly acidic ice-water to collect the precipitate by filtration, followed by drying. Yield: 18 g; mp. 95°-98° C. (dec.)
80 ml of thionyl chloride was gradually added to a benzene suspension of 217 g of 5-bromosalicyclic acid and 113 g of phenol, followed by refluxing for ten hours under heating. After distilling off the benzene, ice-water was added to the residue, and the precipitate formed was collected by filtration, followed by drying. Yield: 210 g.
A methanol solution of 127 g of KOH was gradually added to a methanol solution of 210 g of phenyl 5-bromosalicylate prepared as in (2-1) above and 105 g of hydroxylamine hydrochloride. After stirring for 4 hours, the precipitate formed was collected by filtration. The precipitation was then suspended in water, and 60 ml of conc. hydrochloric acid (35%) was added thereto, followed by stirring for two hours to collect the precipitate by filtration followed by drying. Yield: 136 g.
81 ml of triethylamine was gradually added to a dimethylformamide solution containing 136 g of 5-bromosalicylhydroxamic acid prepared as in (2-2) above and 54 ml of N,N-dimethylcarbamyl chloride at room temperature (about 20°-30° C.), then stirred for 10 hours. This solution was poured into ice-water to collect the precipitate by filtration followed by drying. Yield: 102 g; mp. 118°-119° C. (dec.)
20 g of phosgene was absorbed by dichloromethane cooled to -40° C., and 8.4 g of dibutylamine was gradually added thereto. Excess phosgene and dichloromethane were distilled off at room temperature under reduced pressure. The residue was extracted with hexane, washed with water, and dried. Then, hexane was distilled off to obtain a colorless liquid. Yield: 7.5 g.
6.0 g of salicylhydroxamic acid, 7.5 g of N,N-dimethylcarbamyl chloride prepared as in (3-1) above and 5.4 ml of triethylamine were reacted in the same manner as in Synthesis Example 1. The reaction solution was poured into ice-water, extracted with ethyl acetate, dried, and purified through column chromatography. Yield: 11.2 g (oil)
Other compounds of this invention than the above-described compounds of this invention can be synthesized according to the above-described process.
The base precursors of the present invention can be used in various fields.
One example thereof is to use them in thermally developable diazo copying materials, e.g., described in Japanese Patent Application (OPI) Nos. 11229/75, 109924/77, 45094/82, 133033/80 and 150014/77, Japanese Pat. Publication Nos. 19620/81, 24726/68, 40455/76, 41202/73 and 28663/69, etc.
In using the compounds in thermally developable diazo copying materials, a light-sensitive diazo compound, a coupling component, and a substance capable of producing a base upon heating, i.e., a base precursor, are incorporated in a light-sensitive layer. These copying materials undergo a coupling reaction when heated to about 100° to about 200° C. to form azo dyes.
The compounds of the present invention can be employed in the thermally developable diazo copying materials and the diazo copying process as described above.
Descriptions of thermally developable light-sensitive materials using silver halide and process of using them are found in, for example, Shashin Kogaku no Kiso (1979, Corona Co.), pp. 553-555, Eizo Joho (Apr. 1978), p. 40, Nebletts Handbook of Photography and Reprography, 7th ed. (Van Nostrand Reinhold Company), pp. 32-33, U.S. Pat. Nos. 3,152,904, 3,301,678, 3,392,020, 3,457,075, 3,531,286, 3,761,270, 3,985,565, 4,021,240, 4,022,617 and 4,235,957, British Pat. Nos. 1,131,108 and 1,167,777, Belgian Pat. No. 802,519, Research Disclosure, May, 1978, pp. 54-58 (RD-16966), ibid., June, 1978, pp. 9-15 (RD-17029), ibid., April, 1976, pp. 30-32 (RD-14453), ibid., December, 1976, pp. 14-15 (RD-15227), etc.
In the thermally developing process using silver halide, a light-sensitive material is used which comprises a support having thereon a layer containing (1) a light-sensitive silver halide emulsion, (2) a composition capable of producing a base upon heating, and (3) a developing agent for silver halide. When such a light-sensitive material is imagewise exposed and heated, the developing agent becomes activated with the base and exposed silver halide is reduced to form a silver image.
The compounds of the present invention can be employed in the silver halide type thermally developable light-sensitive materials as described above and the process using them.
Further, the compounds of the present invention can be employed in heat-sensitive materials as described in Japanese Pat. Publication No. 29024/76, Japanese Patent Application (OPI) Nos. 147949/75, 82421/78 and 99951/78, etc.
The base precursors of the present invention effectively produce bases in the substantial absence of water. Therefore, the base precursor of the present invention can be advantageously used in where chemical change is intended by a base to be produced by heating.
The amounts of the base precursors which can be used in the above-described cases will vary depending upon kind of compound and kind of system in which the compound is used. However, in general compound of the present invention is suitably used in an amount of 0.01 to 50 wt% based on the total weight of the coated layer, with 0.01 to 30 wt% being more preferable. The base precursors of the present invention may be used alone, or two or more of them may be used in combination, if desired. Further, they may be used together with base precursors outside the scope of the present invention.
The present invention is described in greater detail by the following examples which, however, are not to be construed as limiting the present invention in any way. Again, unless otherwise indicated, all parts percents, ratios and the like are by weight.
20 mg each of Base Precursors Nos. 1, 3, 4, 10 and 15 of the present invention was placed in test tubes and immersed in an oil bath heated to 150° C. After being allowed to cool, 1 ml of 50% ethanol was added thereto, and several drops of the following pH indicators were added thereto to observe what change of color occurred.
|pH Indicator Color Change
A. Thymolphthalein ethanol solution
B. 0.1% Ethanol solution of phenol-
C. 0.1% Ethanol solution of α-
As a control, 20 mg of each of the above-described base precursors was dissolved in 1 ml of ethanol and, after adding thereto 1 ml of 50% ethanol, the pH indicators were added thereto to determine what color change occurred. As a result, every base precursor of the present invention described above was decomposed by heating to change the colors of all pH indicators A, B, and C as described above. In the control test, the colors of the pH indicators were not changed.
Additionally, the activity of the base precursor can be presented in the following order depending on the kind of pH indicators of which colors they can change.
|Activity pH Indicators Changed in Color
large A + B + C
small C alone
From the above results, the base precursors of the present inventions are found to effectively produce bases upon being heated.
About 400 mg of the base precursor of the present invention was dissolved in 25 ml of methanol. Separately, 400 mg of gelatin was dissolved in 5 ml of water with heating. After cooling, 5 ml of the above-described methanol solution was added thereto and the mixture well mixed. The resulting mixture solution was uniformly coated on a triacetyl cellulose support and dried to prepare samples.
The absorbance of each of the samples at λ max (around 300 nm) was previously measured, then the sample was heated on a hot plate at a definite temperature. The change in absorbance versus time was plotted to calculate first-order reaction rate.
Several examples of the reaction rate constants measured by the above-described method are given below.
|K at 140° C. Half-Life Period Sample (× 102) t1/2 (sec)
Base Precursor No. (1)
6.7 10.3
Base Precursor No. (37)
3.7 18.7
Base Precursor No. (38)
9.0 7.7
In view of the fact that the half-life period of a known base precursor is 60 seconds, the above-described half-life periods reveal that the base precursors of the present invention have remarkably high activity.
A thermally developable diazo composition of the following formulation was coated on a polyethylene terephthalate support in a wet thickness of 100μ.
|(a) ##STR15## 30 mg (b) ##STR16## 60 mg (c) Base Precursor (1) of the Present Invention 120 mg (d) 10% Methylene Chloride Solution of 5 ml Polyvinylidene Chloride (e) Acetone 5 ml
After drying, the sample was exposed to UV light through a transparent image original using a conventional diazo exposure apparatus, then uniformly heated on a heat block heated to 140° C. for 30 seconds to develop. A positive image having an optical density of 1.10 was obtained.
A composition of the following formulation was uniformly coated in a wet thickness of 60μ on a polyethylene terephthalate support and dried to prepare a light-sensitive material.
|(a) Silver Bromoiodide Emulsion 10 g (AgI: 10 mol %; containing 5 wt % gelatin and silver) (b) Gelatin (10% aqueous solution) 5 g (c) Solution of 0.2 g of 2,6- Dichloro-p-aminophenol in 15 cc of Water (d) Coupler Dispersion (*) 3.5 g (e) Solution of 0.25 g of Base Precursor (1) of the Present Invention in 2.5 cc of Ethanol
The coupler dispersion (*) was prepared as follows.
5 g of 2-dodecylcarbamoyl-1-naphthol, 0.5 g of sodium 2-ethylhexyl succinate sulfonate, and 2.5 g of tricresyl phosphate (TCP) were weighed, and 30 ml of ethyl acetate was added thereto to dissolve these materials. This solution was mixed with 100 g of a 10% gelatin aqueous solution and stirred for dispersion.
The thus obtained light-sensitive material was imagewise exposed for 5 seconds at 2,000 lux using a tungsten electric lamp. When the material was uniformly heated on a heat block heated to 140° C. for 20 seconds, a negative cyan color image was obtained. The density of the image was measured using a Macbeth transmission densitometer (TD-504) to obtain a maximum density of 2.15.
While the invention has been described in detail and with reference to specific embodiments thereof, it will be apparent to one skilled in the art that various changes and modifications can be made therein without departing from the spirit and scope thereof.


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A majority of Indian youth is completely indifferent towards the political situation in the country. We have youth toppling autocratic and totalitarian regimes in the Middle East. But Indian youth is entangled in a web of superficial comfort.
Our children are easily stressed out these days owing to the stiff competition that they have to face in every sphere of life. Studies, peer pressure, etc., are robbing them of the simple pleasures of childhood. Are parents to be blamed?
If political parties in different states, both ruling and opposition, are so dead against alcohol, why don't they just pass a law, banning alcohol from their states? Then the whole country will be liquor-free.
Reality television and its negative impact on Indian society is a much talked-about issue these days. Everyone blames the channels and the producers for attempting to corrupt the social fabric of the country through the onscreen profanity.


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To register for C3D training, please visit: C3D Training Schedule
At the end of 2003, the National Cancer Institute's Center for Cancer Research (CCR) developed and started using the Cancer Central Clinical Database (C3D) - a client-server computer system - to capture data for oncology clinical trials research trials conducted at the CCR.
This manual was developed for data managers and study coordinators responsible for capturing patient data from BTTC clinical trials into C3D. It contains general instructions on how to complete the Standard Case Report Forms (eCRF) developed for BTTC trials, such as time frames for data entry. It also includes specific details on how to complete each eCRF, defining the required fields, pick lists available and validations to assist with data entry.
If you have questions or comments, please forward your feedback on this manual to the NCI Brain Tumor Trials Collaborative.
|General Instructions for completion of all Case Report Forms


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British Energy (BE) and the UK-based engineering consultants NNC have announced an agreement to combine their consultancy groups to form BE NNC International Consulting.
The two companies have worked together for 40 years, and for the last seven years they have collaborated to support aid programmes focused on enhancing the nuclear safety of reactors in central and eastern Europe.
The new company said it will continue to work in this area, pursuing a number of projects, including project management of the Chernobyl and Ignalina units, on-site assistance at Smolensk, institutional support for the Ukrainian generator Energoatom and various UK government, EBRD and EC-sponsored programmes in Russia, Ukraine, Bulgaria, Romania and the Czech Republic.


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Brendan Jou, Shih-Fu Chang. Deep Cross Residual Learning for Multitask Visual Recognition. In ACM International Conference on Multimedia, Amsterdam, The Netherlands, 2016.
Download paper: Adobe portable document (pdf)
Copyright notice:This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. These works may not be reposted without the explicit permission of the copyright holder.
Residual learning has recently surfaced as an effective means of constructing very deep neural networks for object recognition. However, current incarnations of residual networks do not allow for the modeling and integration of complex relations between closely coupled recognition tasks or across domains. Such problems are often encountered in multimedia applications involving large-scale content recognition. We propose a novel extension of residual learning for deep networks that enables intuitive learning across multiple related tasks using cross-connections called cross-residuals. These cross-residuals connections can be viewed as a form of in-network regularization and enables greater network generalization. We show how cross-residual learning (CRL) can be integrated in multitask networks to jointly train and detect visual concepts across several tasks. We present a single multitask cross-residual network with >40% less parameters that is able to achieve competitive, or even better, detection performance on a visual sentiment concept detection problem normally requiring multiple specialized single-task networks. The resulting multitask cross-residual network also achieves better detection performance by about 10.4% over a standard multitask residual network without cross-residuals with even a small amount of cross-task weighting
Brendan Jou
Shih-Fu Chang
Author = {Jou, Brendan and Chang, Shih-Fu},
Title = {Deep Cross Residual Learning for Multitask Visual Recognition},
BookTitle = {ACM International Conference on Multimedia},
Address = {Amsterdam, The Netherlands},
Year = {2016}
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Why TV Personalities Take HGH Supplements
Human Growth Hormone supplements (HGH) are used by many as anti aging supplements.
People use either the natural HGH supplements or the artificial HGH injections to increase the hormone levels of human growth.
Natural HGH supplements are also known as HGH releasers. They contain certain ingredients that help stimulate an individual's body to naturally produce more hormones for human growth.
These ingredients include minerals, herbs, amino acids, plant extracts and vitamins.
However, as people grow older, their bodies tend to reduce the HGH amount produced everyday .This drop in in production of HGH causes the aging process in people and makes aging symptoms more easily noticeable .
In order for one to slow the aging process, they need to increase HGH levels .There are only two ways which one can use to do this i.e. taking Natural HGH supplements or Artificial HGH injections.
Artificial HGH injections are very expensive and have very adverse effects to an individual .Using them can lead to the shutting down of the pituitary gland, which is the most common side effect.
In this case, the pituitary gland stops to produce HGH completely and one has to rely on continuous artificial injections for them to lead a healthy life. Artificial HGH injections should thus be the last option for anti aging therapy.
HGH supplements are very new in the market but have within time become very popular for anti aging therapy among artists, public figures, TV personalities and other celebrities
When they were first introduced in the market , HGH supplements were believed to be the youth mythical fountain . However with so many HGH supplements brand, people are reporting side effects after taking natural HGH supplements.
Regular use of natural HGH supplements has very many beauty and health benefits that include the following:
- Improved skin texture and stronger bones.
- Improved sexual stamina and an increase in sex drive.
- Increased body energy.
- Reduction of the excess fats in the body.
- Muscle mass that is leaner.
- Increased physical energy and stamina.
- Faster healing of wounds.
- Sharper and improved eyesight.
- Reduction in age spots and wrinkles on one's skin.
- Building the immune system.
- Enables regrowing of hair.
- Improved sense of well being and mood.
- Enable color restoration.
- Improved alertness and concentration.
TV personalities need to maintain their looks as they appear to before the public's eyes and are thus regarded as celebrities .An unhealthy, overweight and out of shape news anchor, journalist, comedian or presenter may be very unattractive to viewers. Aging rapidly is not good for one's health and also makes one looks rather bad on the camera.
TV personalities can use natural HGH supplements to improve their physical appearance.
This may enable them to maintain their TV audience and even attract more audience. Natural HGH supplements enable complete transformation of the body within two to three months of continuous use. High quality brands of these supplements do not have any adverse side effects to an individual.


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File Size: 923 KB
Print Length: 352 pages
Publisher: Macmillan; Unabridged edition edition (April 1, 2011)
Publication Date: April 1, 2011
Language: English
Download (eBook)
Wiseman's prose is warm and funny and easy to see and understand. You can tell how much he loves this subject and how great he has had executing research over the years.
I love this guide and I only wish I actually could get a printing copy for my non-Kindle-owning father. Please, somebody distribute it in the US in printing form!, Paranormality is a fantastic addition to the skeptical library. It covers a few of the same ground because the old skeptical classics like the Demon-Haunted World by Carl Sagan and Flim-Flam! Psychics, ESP, Unicorns and Other Delusions by James Randi, but in a more light-hearted and interactive manner. Professor Wiseman is a psychiatrist and he shows all of us not only why things such as ghosts and psychics don't exist, but why we are fooled into thinking they do.
One of the things that makes the guide stand out is the top number of experiments and exercises you can do to illustrate Wiseman's points. They are simple but really help the reader understand how the brain works. The book also has QR tags which means you can watch videos of selection interviews and investigations.
A number of subjects are covered in addition to psychic powers and ghosts, such as a hypnotic approach, cults, prophesy, out-of-body activities and seances. I found the chapter on dreaming especially interesting. He deftly interweaves his own researched activities with stories of charlatans and the dupes through the years.
Although the book has been a major seller in the U. K., Professor Wiseman has been unable to find an American publisher. This is a shame since there is probably no country more needing a guide like this. Fortunately for those of us in the U. S., this individual has put the e book on Amazon so we can read it.
Paranormality is a smart, fun read. In an ideal world, it would be required reading for all those high school students. It would surely make us a nation of smarter, less gullible citizens., Highly recommended - written with integrity, up-to-date research, from a balanced and tolerant view, very enjoyable and informative
It is gloomy that in the US it is available only on Kindle fire -- publishers concluded that inside our religion-brainwashed population there will not be an interest in the topic. Many thanks a lot to Prof. Wiseman for his huge effort - presented in condensed and witty form and always with credit to his sources, Loved this book! I actually don't see dead people anymore. Just kidding. From the good read. Very informative and maybe a little disappointing. All of us like to believe there's a little magic here and there. But I definitely feel this all must be said. Fascinating study and enjoyable read., My first book I've read from Wiseman. He's quite a interesting guy and Trying to find following him through the years through his podcast and blog, and I thought I'd give his textbooks a try. His information is pretty good and extremely detailed.
if he mentions the history of a claim or idea, I feel he retains it concise to the level that it's not boring or detracting from the matter at hand, and his use of humor throughout the book keeps it quite interesting. My only problem with it is that he seems to sometimes restate points that do not need to be restated. For example, many times, after discussing a claim and how it fits into the natural world, there appears to be what almost feels like filler in the book where he basically recaps what he just spent the last 2 or 3 pages talking about. This happens often, but it's only for like a paragraph so it's not really an issue, I just glance over them., Excellent book. I am a Psychology student and have always had an interest in the paranormal as well (as should be evident by my name). I actually thought Wiseman did a fantastic job debunking a lot of the " paranormal" activity that is out there. He didn't manage to complete debunk ghosts, but he gave some sensible explanations for a lot of of the things people experience. In addition to, let's face it, an entire book could be dedicated just to the topic of ghosts.
Professor Wiseman has my business.
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text: Purpose This study was conducted to research the mutation spectral range of the cytochrome P450 gene (from 41 Chinese PCG patients were analyzed using polymerase chain reaction (PCR) and heteroduplex analysis-single strand conformation polymorphism (HA-SSCP) accompanied by subsequent cloning and bidirectional sequencing. a significant gene for PCG, showing 20263-06-3 manufacture up to lead to the disease in a single in six Chinese PCG sufferers roughly. The R390H mutation was defined as a predominant allele among the Chinese language PCG sufferers in our research. This observation stresses the need for mutational testing of (OMIM 601771), situated in the GLC3A locus, continues to be characterized. The individual includes three exons using the translated area beginning on the 5 end of the next exon. It encodes a known person in the cytochrome P450 superfamily, subfamily I. The merchandise is normally a 543 amino acidity long proteins which has conserved core buildings (CCS), which 20263-06-3 manufacture include four helix bundles (helices D, I, and L as well as the antiparallel helix E), helices K and J, -bed sheets 1 and 2, a heme-binding area, and a meander area. Many of these locations are located inside the COOH-terminal half from the CYP1B1 proteins and are anticipated to be engaged in heme-binding and correct folding from the molecule [7]. CYP1B1 is normally a membrane-bound monomeric blended function mono-oxygenase that's expressed mainly in the trabecular meshwork but also in the posterior portion of the attention, in the neuroretina notably, and other tissue like the adrenal gland, the ovary, the testis, the lung, the uterus as well as the kidney [8]. The proteins is probably from the fat burning capacity of substances that are vital towards the developing eyes [9]. Mutations in may be the predominant reason behind autosomal recessive inherited PCG that is reported in a variety of cultural backgrounds [6,10-13]. Up to now, the spectral range of mutations leading to PCG in the Chinese language population isn't yet well known. Herein, we looked into mutations in 41 unrelated Chinese language sufferers with PCG. Strategies Patient recruitment The analysis implemented the tenets from the Declaration of Helsinki with created informed consent extracted from all sufferers or off their parents if how old they are was significantly less than 18. Forty-one sufferers with PCG had been recruited in the glaucoma treatment centers at Zhongshan Ophthalmic Middle at Sunlight Yat-sen School (Guangzhou, China). After going through a complete eyes evaluation including slit-lamp biomicroscopy, optic nerve evaluation, and dimension of IOP by Goldmann or Perkins tonometry, all enrolled sufferers were identified as having PCG. Topics with supplementary factors behind glaucoma (e.g., injury, uveitis, steroid-induced- or neovascular glaucoma, and various other linked ocular or systemic anomalies) had been excluded. PCG was described based on the pursuing criteria: age group of onset significantly less than 3 years; IOP higher than 21 mmHg without the treatment; optic nerve cupping, and furthermore, rupture of Descemets membrane, or horizontal corneal size higher than 12 mm with or without corneal edema. Sufferers older than 3 years without supplementary causes but with buphthalmos had been considered to possess PCG. Inside our research, six (14.6%) sufferers had unilateral PCG, and neither a family group background of PCG nor parental consanguinity was established in virtually any from the 41 unrelated Chinese language sufferers. Eighty matched up regular all those without the ocular disorders served simply because controls ethnically. Mutation screening Bloodstream samples 20263-06-3 manufacture were FLJ30619 gathered from 41 sufferers and 80 handles after up to date consent was received. Genomic DNA was extracted from leucocytes by proteinase K-phenol-chloroform removal. Ten pieces of primers (Desk 1) were utilized to amplify the coding parts of ("type":"entrez-nucleotide","attrs":"text":"U56438″,"term_id":"1663555″,"term_text":"U56438″U56438). Polymerase string response (PCR) amplification was performed within a 25 l quantity through a touchdown PCR plan with an annealing heat range lowering from 64?C to 58?C or 56?C over 10 cycles accompanied by 30 cycles with an annealing heat range of 58?C or 56?C. Subsequently, the PCR items were examined by heteroduplex analysis-single strand conformation polymorphism (HA-SSCP) as defined previously [14]. PCR items displaying aberrant banding patterns on SSCP had been sequenced 20263-06-3 manufacture using the ABI BigDye Terminator Routine Sequencing Package v3.1 (Applied Biosystems, Foster Town, CA) relative to the manufacturers suggestions, using an ABI 377 or 3100 sequencer (Applied Biosystems). The fragment filled with the complete second exon was amplified for sequencing with the first group of forwards primers as well as the sixth group of invert primers (Desk 1), the 3rd exon amplified with the seventh group of forwards primers as well as the tenth group of invert primers (Desk 1). Each variant was verified by bidirectional sequencing. Comparative sequencing evaluation between different examples and the typical sequence ("type":"entrez-nucleotide","attrs":"text":"U56438″,"term_id":"1663555″,"term_text":"U56438″U56438) was performed using the SeqManII plan from the Lasergene bundle (DNAStar Inc., Madison, WI). Heterozygous deletions (g.4531_4552dun22bp and g.4633delC) were identified utilizing a monoclone accompanied by direct sequencing. Desk 1 Primer pairs for mutation evaluation. Four mutations had been confirmed by limitation fragment duration polymorphism (RFLP), I471S by.


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Women's Metallic Margaux Python Silver
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5 Tips about kdp rocket coupon code You Can Use Today
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