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Profile: Nome Safety Fair
Nome Emergency Service providers and Norton Sound Injury Prevention will host a Safety Fair in Nome this Saturday at the Nome Elementary School parking lot. Bike safety and registration will be areas of focus.
Presenters will also address gun and boating safety. Ambulance crews will be on hand with emergency planning information. The Safety Fair takes place this Saturday from 11:00 a.m. to 3:00 p.m. at the Nome Elementary School parking lot.


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ECU surgeon elected president of Society of Thoracic Surgeons
GREENVILLE, N.C. (Jan. 31, 2008) — Dr. W. Randolph Chitwood Jr. was elected president of the Society of Thoracic Surgeons during the group's 44th annual meeting Jan. 27-29 in Fort Lauderdale, Fla.
Chitwood is senior associate vice chancellor for health sciences at East Carolina University and founding director of the East Carolina Heart Institute.
During his term, Chitwood plans to take a more active role in international cardiothoracic surgery issues, work on government policy issues, develop additional clinical guidelines and increase efforts to better foster upcoming generations of cardiothoracic surgeons.
"We need to utilize new technology and the impact it has in patient care to increase the interest surgeons have in our specialty," Chitwood said. "It will also be important in the coming year to think about how we can blend our influence in areas of public policy and new technology with other professional organizations."
Chitwood has a bachelor's degree from Hampden-Sydney College in Virginia, a medical degree from the University of Virginia and completed his surgical residency at Duke University Medical Center. He came to ECU in 1984, where he started the cardiac surgery program. After a brief stint at the University of Kentucky, he returned to ECU in 1989 and served as chairman of the Department of Surgery from 1995-2003.
Chitwood has been involved with STS throughout his career, taking his first leadership role in 1994. He has been active on a variety of the society's workforces, particularly those regarding the planning of the annual meeting. In 2003, he was elected to fellowship of the Royal College of Surgeons of England and is a former president of the International Society for Minimally Invasive Cardiac Surgery and the Society for Heart Valve Disease. He serves or has served on the editorial boards of the Annals of Thoracic Surgery, the Journal of Cardiovascular and Thoracic Surgery, the Journal of Cardiac Surgery, the Journal of Heart Valve Disease, the Asian Annals of Cardiovascular and Thoracic Surgery, CTS Net, the Heart Surgery Forum, Chest and the American Heart Journal.
Chitwood is a pioneer in developing new technology for minimally invasive heart surgery. His Robotic Surgical Center has trained more than 350 surgeons from around the world in the robotic surgical techniques. Chitwood also pioneered robotic valve repairs using the da Vinci system, and in 2000, used it to perform the first complete mitral valve repair in North America. He was the lead investigator of the FDA robotic mitral valve trials. Chitwood has special expertise in complex valve surgery including mitral repair as well as aortic valve and cardiac rhythm surgery.
The Society of Thoracic Surgeons is a non-profit organization representing more than 5,400 surgeons, researchers, and allied health professionals worldwide who provide heart, lung, esophageal and other surgical procedures of the chest. Its mission is to help cardiothoracic surgeons serve patients better.
Doug Boyd
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In cooperation with Cotton Incorporated and the Agricultural Research Service (ARS) of the United States Department of Agriculture (USDA), Mulch & Seed Innovations, LLC has developed two all-natural cotton-fiber hydromulch products that help control soil erosion – GeoSkin™ cotton hydromulch (used for semi-flat terrains) and HydraCX2® high-performance cotton hydromulch (used for steep slopes).
According to Tom Wedegaertner, Cotton Incorporated's Director of Cottonseed Research and Marketing, byproducts of the cotton ginning process create 2.5 million tons of bio-mass each year. "By converting a portion of this into hydromulch, it creates a practical use for what used to be identified as simply waste," he says, "ultimately increasing the overall demand for cotton."
Hydraulically applied, GeoSkin and HydraCX2 perform better than wood, paper or synthetic mulches – and establish grass seed more quickly while protecting the soil against unfavorable weather conditions like heavy wind and rain. Wedegaertner explains that the technology behind the cotton-fiber hydromulch allows "the soil to stay put so it can absorb an adequate amount of moisture and quickly establish germination, adding nutrients to the soil for long-term erosion control."
"Cotton by nature is porous, absorbent and biodegradable – the perfect trio for controlling erosion and establishing seed," affirms Mulch & Seed Innovations Vice President of Sales and Marketing, Wae Ellis.
The products are marketed with Cotton Incorporated's GeoPhillics™ trademark (meaning "Earth loving cotton"), which incorporates the highly recognized Seal of Cotton trademark, which Wedegartner says helps consumers identify Mulch & Seed Innovation's cotton-based seed nurturing and soil stabilizing products. "Studies have shown that eight out of 10 consumers recognize the Seal of Cotton," he says, "so marketing these hydromulches with the GeoPhillics trademark hopefully provides consumers with an initial trust of the product."
Produced exclusively by Mulch & Seed Innovations in Centre, Alabama, GeoSkin has eight distributors within the U.S., which can be found at http://geoskin.com/ , while HydraCX2 is now distributed by North American Green (http://www.nagreen.com/) – a leading erosion control solutions provider – as their first product in its new line of HydraMatriCx® products, increasing its distributors to nearly 70 worldwide.
Both products are also cost effective compared to other mulches and have a favorable deep-green color that adds to its natural character. For more information about GeoSkin™ and HydraCX2, visit http://mulchandseed.com/.


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Brexit's Effect on U.K. Life Sciences
Making the Nation a One-Stop Regulatory Engine for Innovation
Top 10 U.S. Biopharma Clusters
The Rich Get Richer in GEN's Annual Ranking of the Nation's Top Regions
Bioprocessing Companies Push Limits of Upstream Technologies
Goal Is to Maximize Efficiency in Bioprocess Operations
This is Your Brain on DREADDs
Chemogenetics Provides a Noninvasive Tool for Precise Control of Neural Circuits
Antibodies Against Membrane Protein Targets
Lipoparticle Technology Facilitates Discovery in This Challenging Protein Class
Integral membrane proteins such as GPCRs and ion channels represent key molecules involved in cell signaling, cell homeostasis, and human disease, with one-third of all approved drugs targeting such proteins. Despite the clinical relevance of membrane protein targets, monoclonal antibodies (mAbs), especially those targeting conformational epitopes, have been difficult to develop.
As a result, fewer than a dozen mAbs have been described that target conformational epitopes on the 426 ion channels and 533 transporters in the human genome. Similarly, the vast majority of the 907 human GPCRs have no inhibitory or conformation-dependent mAbs available. While the number of FDA-approved therapeutic mAbs continues to grow, only two of these mAbs target multiple-spanning membrane proteins (CD20 and CD25) and none target the largest membrane protein families, GPCRs, ion channels, or transporters. The lack of monoclonal antibody reagents against this important class of proteins reflects the need for more effective mAb discovery approaches.
Antibodies that recognize conformation-dependent epitopes on membrane proteins are usually the most valuable type of antibody for therapeutics and diagnostics because they can bind to critical structures of the receptor that are required for function and can detect the protein as it exists on the cell surface. However, deriving such antibodies requires presenting membrane proteins to the immune system in their native conformation and orientation. Current immunization approaches using peptides, purified membrane proteins, membrane preparations, or whole cells have had limited success in eliciting conformational antibody responses against many membrane protein targets.
For example, widely used whole cell immunogens preserve native membrane protein topology, but often lack sufficient concentrations of the target protein due to low expression levels, protein toxicity, poor trafficking to the cell surface, or interference from other cellular proteins. New immunization approaches that offer high concentrations of complex membrane proteins in their native structure are essential for generating antibodies against clinically relevant membrane protein targets.
The Lipoparticle developed by Integral Molecular represents a useful technology for immunization and antibody discovery applications against membrane protein targets. Lipoparticles are virus-like particles (VLPs) that incorporate high concentrations of target membrane proteins in their native conformation. Lipoparticles are produced in mammalian cells by co-expressing a retroviral structural core polyprotein, Gag, along with a user-specified membrane protein which is correctly translated, folded, and post-translationally modified.
Gag core proteins self-assemble at the plasma membrane, where they bud off and capture target membrane proteins directly from the cell surface at concentrations of 50–200 pmol/mg, approximately 10–100 fold higher concentration than cells or membrane preparations. Immunization with Lipoparticles presents high concentrations of membrane proteins in their native topology to the immune system, making them well suited for antibody elicitation.
Generating Immune Responses
Lipoparticles have been used to generate reactive immune sera against all major classes of membrane proteins, including GPCRs, ion channels, transporters, oligomeric single-transmembrane proteins, and other multispanning membrane proteins. For example, Lipoparticles containing the GPCR CXCR4, the ion channel Hv1, the tetraspanin claudin-1, the transporter Glut1, and the single transmembrane (TM) oligomeric protein CD27 were each incorporated into immunogen-grade Lipoparticles and used to immunize mice.
In all cases, specific serum responses against each target were observed under native conditions by flow cytometry (Figure 1A) and under denaturing conditions by Western blot (Figure 1B). By comparison, traditional immunogens such as whole cells and membrane preparations yielded weaker responses. For example, transfected cells and membrane preparations containing the GPCR CXCR4 elicited weak immune responses to CXCR4 while the strongest immune responses (50% serum reactivity >1:500) were obtained with CXCR4 Lipoparticles (Figure 1C).
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ASUNCION, Paraguay (AP) — A new action movie featuring a poor delivery boy whose life depends on the mysterious cargo in his wheelbarrow has Paraguayans excited and proud to see their gritty reality on the big screen for the first time.
While audiences have been delighted by "7 Cajas," the movie shot in a chaotic market in this South American capital has nevertheless jarred many with its focus on the darker angles it shows: a suffocating mix of official negligence, societal indifference, police corruption and organized crime that keeps most of the population mired in poverty.
"I loved the movie," said 30-year old architect Antonella Cantero. "It is just that for some of us it becomes hard to watch, something that is so tough and so common at the same time, and we prefer to hide."
It's an odd mix of emotions for people unaccustomed to seeing any cinematic depiction at all of their country. The nation's movie industry is virtually nonexistent, and U.S. films dominate the country's fewer than 15 theaters, most of them in the capital of Asuncion.
"Fast and Furious on Wheelbarrows" is how one critic described "7 Cajas," referring to the action series about heists and street races. It has wowed festival audiences, filled Paraguay's theaters since August and will soon be distributed around the world.
The film is drawing comparisons to India's "Slumdog Millionaire" in how it gets audiences rooting for a poor slum kid, Victor, a wheelbarrow delivery boy summoned by a small-time crook to carry a mysterious load of boxes across the market for $100 — a huge fortune for a slum kid in a country where the extremely poor don't make $2.50 a day.
"Listen up, little one. You must protect these seven boxes with your life. Understand? And when the boxes show up again, I'll give you the other half," the crook says, tearing the $100 greenback in two.
Things quickly get complicated along the slum's dark corridors, where Victor runs for his life from criminals and police.
The fast-paced film has cinematic touches straight from Hollywood, but also an authenticity that comes from being shot on location with a relatively inexpensive camera on a budget of just $650,000.
Except for the central characters, nearly everyone who appears in the film lives or works in Municipal Market No. 4, a sprawling collection of tents, shacks and building corridors in downtown Asuncion. There, practically anything can be bought or sold, from legal products to smuggled fruit, stolen cellphones and fake DVDs. Even illegal drugs can be purchased clandestinely by buyers who know where to look for them. The characters speak jopara, a street language that mixes Paraguay's two official languages, Spanish and the native Guarani.
Paraguayan directors Juan Carlos Maneglia and Tana Schembori told The Associated Press they aimed to make a fun film, not a social statement.
"Maybe it was a very unconscious objective," Maneglia conceded. "It really wasn't my intention to depict our reality faithfully, but for it to be entertaining, and to have an interesting message."
Celso Franco, the 23-year-old first-time actor who stars as Victor, said he sees the film as a protest.
"We are so tired of some things; we want people to see our reality," said Franco, who was raised by his grandmother in Paraguay's countryside after his parents left for Spain to work and send money home to support him and his brothers.
"This is a demonstration of how we are living in Paraguay and we know that it reaches people in power, and at least they'll feel a little bit guilty, the ones in power now who can change some things," Franco said.
The evident poverty of the characters is a reality for most of Paraguay's 6.5 million people. While booming soy prices have raised the country's gross domestic product for three straight years, a tiny upper class has held onto nearly all the wealth. Democratic governments have failed to budge the 55 percent poverty rate since a 35-year dictatorship ended in a coup in 1989. Of the nation's impoverished, 31 percent live in extreme poverty, according to U.N. statistics.
International distributor Shoreline Entertainment is expected to bring "7 Cajas" to audiences around the world next year, shaping first and lasting impressions about Paraguay.
"I don't understand why people come out laughing from the movie theaters like it was a comedy," said Silvia Mongelos, 31, who works in an environmental foundation. "The movie is a social protest, from beginning to end, of our terrible reality."
Maneglia, the director, emphatically denies trying to send that message.
"It's too big of a responsibility," Maneglia said. "I don't think it encompasses all we are."
Shoreline Vice President Sam Eigen agreed. "Before it focuses on any kind of social issues or relates to a particular situation in Paraguay, the feeling after watching the film is that its first priority is to be fun and entertaining," Eigen said.
The filmmakers got funding from Paraguay's government, cultural foundations and a private bank, but still came up short until they won a 100,000-euro ($128,000) "Films In Progress" award at the San Sebastian Film Festival in Spain last year, allowing them to finish the low-budget project.
The finished film won San Sebastian's Youth Award this year, along with Best Dramatic Feature at Sydney's Cockatoo Island Film Festival. Showings then sold out at the Toronto Film Festival in September, where Shoreline outbid other distributors for the international rights.
"People couldn't stop clapping, some had tears in their eyes," Schembori said of the Toronto event.
"7 Cajas" isn't among this year's record 71 submissions for best Foreign Language Film. Without any experience in such matters, the producers and the government's culture secretary missed the Academy Awards' submission deadline.
The film has sold a national record 300,000 tickets at about $5.50 apiece since "7 Cajas" premiered in August. Its producers now plan to travel the country showing the movie in churches and gathering halls, sometimes to people who have never seen films on a big screen before.
They're also organizing a free showing inside Municipal Market No. 4, keeping a promise they made to the workers there.
"They feel like this is their movie," said Schembori. "It is their movie."


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Go Green: Growing Food, Growing Health takes long view on school gardens
- on November 5, 2012
As a nutrition educator, Nancy O'Connor had worked with children for years. She invented many creative ways to talk about calories and nutrients, such as spooning 10 teaspoons of sugar into a pile to show them how much they were getting in one can of pop.
But she still wasn't entirely getting through. What could she do, she wondered, to "crack the nut" of children's disconnect with food? She found just the tool at a sustainable agriculture conference in Des Moines in 2010.
That year, she and the Community Mercantile Education Foundation, a sister organization to The Merc, 901 Iowa St., of which she is executive director, launched the first school garden at West Middle School, 2700 Harvard Road.
"Kids are bombarded with fast food on the landscape. They see it everywhere — it's a very physical part of their reality," she says. "Similarly, this garden is part of the landscape now. Since it's on Crestline (Drive), it's highly visible to kids, their parents and the community. Our success has been very visible."
Thus began the school garden nonprofit program, "Growing Food, Growing Health," which now has gardens at Hillcrest School, 1045 Hilltop Drive, and Sunset Hill School, 901 Schwarz Road, as well. Because the program is sponsored by The Merc, it promises to have lasting success, where a student–parent effort might falter when the students graduate.
Changing minds and habits requires patience and the long view, which is just what O'Connor says this unique business–school district partnership can provide.
Not only do students get to see the gardens in action, the program also provides five select students a job during the growing season, which is roughly April to November. Because it's a real job — each student gardener makes $1,000 per season — the application process is rigorous.
To be considered, they have to volunteer at a spring work day. They each fill out an application and a self-evaluation of their skills related not only to gardening but also public speaking and their ability to work with others. They also need a teacher reference. Finally, they have to write an essay about why they want the job.
"After this careful screening, we're left with a small group of smart, self-aware leaders," says O'Connor. "They care about healthy eating and the environment. Ultimately, many of them have comfortably spoken at state agricultural conferences."
Everything students learn, they learn by doing with the help of garden coordinator Lily Siebert, who doesn't assume anything.
"We make sure we tell them, 'Hey, you have to wash that lettuce' before they bag it up," Siebert says.
The student's hours vary. In the summer they work early morning shifts, and after school in the fall. It depends on what their life looks like.
At the Sunset Hill site, Siebert also teaches a group of sixth-graders who have chosen gardening as an elective. In addition to Siebert and O'Connor, the program has hired local organic grower Dan Phelps to formalize the garden education program at Sunset Hill.
In just three growing seasons, the program has already produced a bountiful harvest. Of the approximately 5,600 pounds of food grown, 1,300 pounds have been prepared and served for lunch by West cafeteria staff, who, along with the principal, Myron Melton, have been very supportive of the project.
The student gardeners also run a Community Supported Agriculture (CSA) project at the Lawrence-Douglas County Health Department for staff of the clinic, Bert Nash Community Mental Health Center and Visiting Nurses Association as part of a Workplace Wellness initiative. All of the proceeds are funneled back into the program, and leftovers are donated to Health Care Access.
"There's been a really positive response," says O'Connor. "When it was 105 degrees outside this summer, people could just walk into the lobby and purchase good healthy food rather than have to drive the farmers' market or grocery store. Each week, someone would say something like, 'I've never prepared beets, turnips, kohlrabi, kale,' and we were there to educate. Not only do we have a generation of students who will never attend a school without a garden, we have adults introduced to healthy local produce. You can create policy to get people to eat, but unless you're on the ground with them, talking to them, showing them real food, change won't happen."
The program can always use interested volunteers. "Growing Food, Growing Growers" is hosting a work day from 9 a.m. to 1 p.m. Saturday at West Middle School. To volunteer, email firstname.lastname@example.com.
Tagged: Go Green, garden, Growing Food, Growing Health
Karrey Britt 5 years, 10 months ago
Huge kudos to Nancy, Lily and Dan for such a great community project. I have enjoyed watching it grow and flourish! This project is helping to make healthy food more accessible — one of the community's Top 5 health priorities.
Richard Heckler 5 years, 10 months ago
Hear hear!
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I think most citizens (if not all) knows very well what their state needs simply because they have ears to listen and eyes to see the reality of life and the needs of state. So, the voice of citizens is important in every deliberation.
By James S. Fishkin, Stanford University
What are the virtues of democratic
citizenship when voters are bombarded by WMD—by which I mean "weapons of mass
distraction"—stinging sound bites and campaign ads from the persuasion industry
funded by a campaign finance system that seems to be broken? Our political
system was born with an ideal of representatives "refining and enlarging the
public views" and hence deliberating on the merits regardless of faction or
partisanship. But the nexus of polling and campaign ads has taken us on a long
journey from Madison to Madison Avenue. Citizens are mostly participants in an
"audience democracy" in which they are occasionally moved to cheer for one side
or another. Not much is expected of them when they are mostly on the sidelines.
To put this in context: What virtues we expect of democratic citizens
depends on what kind of democracy we aspire to achieve. On some theories of
democracy, it does not matter if citizens participate, if they are informed
about the issues they vote on, if they care about the interests of the
community rather than just their personal interests narrowly construed, or if
they are willing to listen to the viewpoints of others. On what is the
currently dominant democratic theory, the competitive democratic view of
theorists like Joseph Schumpeter and more recent followers, all that
fundamentally matters is whether the system has procedurally fair elections to
decide which team of office holders takes office. Democracy is a "competitive
struggle for the people's vote." It is not an exercise in collective will
formation. On the competitive view, if
citizens are misled by false campaigning, or if they mostly get discouraged and
stay home, or if they are aroused by passions or interests adverse to the
rights of others, it does not fundamentally matter. On the competitive view, the
presidential primary process playing out
before us is the epitome of competitive democracy. But from the standpoint of
deliberative democracy advocates, it leaves much to be desired in terms of
levels of citizen information and discussion and in terms of an actual focus on
substantive issues of policy.
One of the arguments in support of
the competitive view is that citizens are not really capable of much more. A
low level of citizen competence, as an empirical matter, justifies low demands
on what citizens can be expected to do. Hence an empirical exploration of
citizen competence would have real implications for whether a more demanding view
of what citizens ought to do is realistic or achievable. But citizens do not
act in isolation; democracy requires an institutional context or design. The
individual virtue of citizen behavior is inextricably tied to the institutions
defining the contexts in which they act.
My colleagues and I are engaged in
a research program in which random samples of ordinary citizens are recruited
to participate in what I call "Deliberative
(see http://cdd.stanford.edu) They discuss policy or political questions in
depth and arrive at considered judgments, revealed in confidential
questionnaires, to provide an input to
policy or politics. In the right context, citizens turn out to be highly
competent to confront difficult trade-offs. They become measurably more
informed, they are open to arguments offered by those with competing
perspectives and they even are willing to make modest sacrifices in the public
interest. In short, in the right context, random samples of the public are
quite capable of behaving a bit more like ideal citizens.
In a series of eight Deliberative
Polls in Texas on energy choices, random samples of the public rose greatly in
their support for renewable energy and conservation and they were willing to
pay slightly more on their electricity bills for it. In a series of decisions
based on these results, the Public Utility Commission and the legislature brought Texas from being
last among the fifty states in wind power in 1996 when we started, to being
first in 2007. People were willing to make at least modest sacrifices in the
public interest (pay slightly higher utility bills to provide a public good for
the environment.) In Northern Ireland and in Bulgaria, Deliberative Polls
showed how mutual understanding and increased tolerance were possible across
deep ethnic divisions. The percentages of Protestants and Catholics who were
willing to say the other community was "open to reason" or "trustworthy" rose
significantly in Northern Ireland. In Bulgaria, in a national Deliberative Poll
on the condition of the Roma, a series of policy attitude changes about
housing, education and the criminal justice system showed a far greater
acceptance of the Roma by the broader community and an embrace of policies that
would integrate them far better. We found similar results in an Australian
project on policies toward the Aboriginals.
In the most recent Deliberative
Poll, What's Next California? a
random sample of registered voters set an agenda for possible initiative propositions
to fix the state. Their deliberations helped give birth to the Government Performance and Accountability
Act which is now going on the ballot for 2012. Their deliberations show how
citizens can become better informed and master the most complex issues of state
government if they are given the chance. If the initiative passes it will be the first time in 2,400
years that a random sample has deliberated and set the agenda for a vote
approved by the rest of the population. The Athenian Council of 500 was
selected randomly and set the agenda for voting in the Assembly just as this
Deliberative Poll set the agenda for voting by the electorate in California.
The Athenians famously expected more of their citizens in their polis than we
do in the modern era. Deliberative democrats are exploring, empirically,
whether modern citizens can live up to similar standards.
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FDA approves Amneal opioid-dependence drug
BRIDGEWATER, N.J. — Amneal Pharmaceuticals has received approval from the Food and Drug Administration for a drug to treat opioid dependence.
Amneal announced Monday the approval of buprenorphine hydrochloride and naloxone hydrochloride sublingual tablets, a generic version of Reckitt Benckiser Healthcare's Suboxone.
Suboxone had sales of $1.5 billion in 2012, according to IMS Health.
Generic tsunami eases, but leaves transformed Rx landscape in its wake
The generic drug tidal wave became a tsunami in 2012, with some of the world's top-selling pharmaceuticals swamped by generic competition, and health plan payers scrambling to reap billions of dollars in financial savings.
Pharmaceutical industry insiders commonly termed last year's market a patent cliff for Big Pharma, and the description fits. Close on the heels of Lipitor's loss of patent protection in late 2011, makers of blockbuster drugs like Bristol-Myers Squibb and Sanofi (Plavix), AstraZeneca (Seroquel), Merck (Singulair), Forest Labs (Lexapro) and Takeda (Actos) joined a cascade of expiring patents and the loss of market exclusivity for their biggest-selling products.
What followed was inevitable: plummeting sales that dropped as much as 90% for some branded drugs, and a massive shift of business in some therapeutic classes like statins to the steeply discounted "me-too" side of the drug sales spectrum. With more than 80% of a branded drug's prescription volume "replaced by generics within six months of patent loss," according to IMS Health, the impact on retail pharmacy's top-line sales and bottom-line profitability — and to consumers' and health plan payers' pocketbooks — also was clear.
The contributions made by generics — both in terms of firming profit margins, and as a cost-saving boon to patients and pharmacy customers — aren't lost on drug retailers large and small, including regional chains like Kerr Drug. "Generics continue to be extremely important to Kerr," said Ted Lingerfeldt, senior director of pharmacy procurement and analysis for the 80-store, Raleigh, N.C.-based drug chain. Kerr, he told DSN, "has recently constructed a new and expanded pharmacy room within our distribution center to handle an increased number of generic pharmaceuticals, including Schedule III to V controlled substances."
Recent financial results at Walgreens, the nation's top pharmacy retailer, illustrate the dual-edged impact that generics typically have on a pharmacy retailer's sales and bottom line. Walgreens has "the best generic dispensing rates in the industry," according to Jeff Berkowitz, Walgreens SVP pharmaceutical development and market access, and in fiscal 2012, generics grew as a percentage of the company's overall prescription sales as big-selling branded drugs like Pfizer's Lipitor fell victim to generic competition.
"The effect of generic drugs, which have a lower retail price, replacing brand-name drugs, reduced prescription sales by 3.5% for 2012, 2.4% for 2011 and 2.2% for 2010," Walgreens reported. However, added the company, "the positive effect of generic drug sales" helped bolster pharmacy margins.
Doug Long, IMS' VP industry relations, concurs. Pharmacy retailers, he agreed, "generally make more margin for a generic product than they do for a branded product, particularly during the exclusivity period."
"Right now, there's plentiful generic opportunities," Long toldDSN."It's almost a who's who list of patent expiries."
That flood of patent expirations will ease somewhat this year, but at least two blockbuster products — Pfizer's groundbreaking erectile dysfunction treatment Viagra and Purdue Pharma's $3 billion pain reliever OxyContin — will face generic competition for the first time. The patent-loss tide will surge again in 2014, with AstraZeneca's $6 billion heartburn treatment Nexium for gastroesophageal reflux disease, Eli Lilly's $3.7 billion NSAID pain reliever Cymbalta and Pfizer's NSAID arthritis treatment Celebrex all joining the post-patent market fray. Add the multiple sclerosis drug Copaxone from Teva to the patent cliff in 2015, followed in 2016 by the blockbuster statin Crestor from IPR Pharmaceuticals and AstraZeneca.
"The number of impactful generic launches anticipated for 2013 will be less than what we experienced in 2012,"noted Kerr's Lingerfeldt. "But we will see a continuation of new generic launches throughout the year, with third quarter seeing several significant launches."
All told, IMS predicts, drugs generating more than $102 billion in combined annual sales will reach the end of their patent life over the next five years.
"Overall, patent expiries in developed markets will yield a five-year 'patent dividend' of $106 billion, reflecting reduced brand spending of $127 billion offset by $21 billion in higher generics spending," IMS predicted in a 2012 report on global pharmaceutical trends.
For pioneer drug manufacturers, IMS researchers foresee "minimal growth in their branded products through 2016," with "flat to 3% annual growth through 2016 to $615 billion to $645 billion, up from $596 billion in 2011." And in the major developed markets, "branded medicine growth will be severely constrained at only $10 billion over the five-year period due to patent expiries, increased cost-containment actions by payers and modest spending on newly launched products," IMS reported. "The impact of patent expiries primarily will be felt in the United States. In Europe, limited savings from expiring patents are prompting policy shifts to encourage greater use of generics and lower reimbursement for these products."
At the same time, "manufacturers of small molecule generics will experience accelerating growth," noted the report. "Global generic spending is expected to increase from $242 billion in 2011 to $400 billion to $430 billion by 2016, fueled by volume growth in 'pharmerging' markets and the ongoing transition to generics in developed nations."
Already, "some 80% of all retail prescriptions filled in the United States are filled with generic drugs," said Margaret Hamburg, commissioner of the Food and Drug Administration.
The most powerful fuel igniting the accelerating boom in "me-too" substitutions, of course, is the obvious and wide cost differential between brands and generics. "The unprecedented savings generated by market competition from generic pharmaceuticals" is now saving U.S. consumers and public and private health plan payers "more than $1 billion in savings every other day," the IMS Institute for Healthcare Informatics reported. That adds up to $1 trillion in savings over the past decade, according to IMS and the Generic Pharmaceutical Association.
"The use of lower-cost generic prescription drugs is a vital component to holding down the growth rate of healthcare spending," IMS noted in its most recent report on generic drug savings. "Generic drug use has saved the U.S. healthcare system approximately $1.1 trillion over the past decade, with $192.8 billion in savings achieved in 2011 alone."
More than half those annual savings — 57% — occur through generic switching of drugs to treat central nervous system disorders — like antidepressants and anticonvulsants — and cardiovascular treatments, according to IMS.
Federal and state health administrators and strategists should do more to capitalize on generics' cost-saving potential, the research firm asserted. "Considering that the government's share of healthcare spending will soon exceed 30% as the oldest baby boomers become eligible for Medicare, the money saved by using generic medicines is critical to bending the cost curve and providing sustainability to our healthcare system," warned IMS.
Given recent federal efforts to create a pathway for FDA approval of biosimilar versions of biologically engineered drugs, that "proven track record of savings for consumers using traditional drugs can be duplicated in the biopharmaceutical market," added the research report, to "inject competition needed in the biologic market to lower costs and provide significant savings for patients in need of these lifesaving treatments."
GPhA president Ralph Neas touted IMS' findings. "The Generic Drug Savings study shows conclusively that, as Congress and the White House gear up for the fiscal challenges facing them in the coming year, generic and biosimilar utilization are the best places to go for the 'offsets' that everyone will be desperately seeking," Neas said. "The sustainability of the healthcare system and the national economy depend in significant measure on the availability of affordable medicines."
Also driving the explosive growth of "me-too" medicines: the growing gap between what patients pay out-of-pocket for branded vs. generic medicines. A recent survey of 424 U.S. employers by the Pharmacy Benefit Management Institute found that retail co-pays for 3.7 million members covered by those employers' health plans are rising for all tiers of prescription drugs, with out-of-pocket costs rising 10% for generics, 13% for branded drugs and 26% for specialty medications. But the cost gap between tiers continues to widen, researchers found, with the differential between generic and preferred brand co-pays now averaging $19, compared with $7 in 2007.
For its part, the branded drug industry appears to have recovered its balance after being staggered by the wave of patent expirations. The industry marked something of a milestone in 2012 in its efforts to regain its momentum, as the FDA approved a total of 39 new drug applications, including eight in the final month of 2012. That wave of approvals — the most NDAs to pass FDA muster in 16 years — could position Big Pharma for a new growth surge, albeit at a more modest pace, as the industry adjusts to a new era of fewer blockbusters and a profound shift of its resources and research efforts into more targeted, patient-specific medicines, biopharmaceuticals and genetic engineering.
The pickup in new drug development (see related story on p. 24) bodes well for the generic industry, as well, since its future viability depends on a steady stream of newly hatched molecular entities and breakthrough products that will eventually succumb to "me-too" competition.
Diplomat software specialist wins MPA award
FLINT, Mich. — A clinical technology manager at Diplomat Specialty Pharmacy has received an award from a state pharmacy association.
Diplomat said Monday that Michael Crowe had received the Fellow of Michigan Pharmacists Association award, announced over the weekend at the MPA's annual convention and exposition in Detroit. According to the MPA, the award "recognizes achievements and dedication to the practice of pharmacy, the community and MPA. The distinction signifies the recipient's actions well beyond the regular practice toward the advancement of pharmacy."
Crowe leads the clinical development of Diplomat's proprietary eNAV software and other clinical programs — as well as researching, reviewing and analyzing the effectiveness and efficiency of existing clinical requirements — and develops strategies for enhancing and leveraging those processes.


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Mumm Basin in Mount Robson Provincial Park
Wells Grey Provincial Park (iStockphoto.com / Glowing Earth Photography)
Epic mountains, sparkling lakes, living rainforests and oceanside trails – there are hundreds of parks in BC to explore.
From world-ranked Stanley Park in the heart of Vancouver to Gwaii Haanas, a UNESCO World Heritage Site that puts the "wild" into wilderness, British Columbia is renowned for having the most extensive parks system in Canada – there are more than 1,000 provincial parks and protected areas, plus many more national and city parks.
Walking and hiking are a given in virtually every park. Beyond that, there is wildlife viewing, backpacking, camping, kayaking and canoeing, swimming, fishing and boating, skiing and boarding, mountain biking and mountaineering.
Vancouver's Stanley Park was named 'Best Park in the World' in TripAdvisor's 2014 "Top 25 Parks" list.
In celebration of Canada's 150th birthday on July 1st, 2017, Parks Canada is offering free admission to national parks and national historic sites for the entire year!
Three of BC's parks are designated UNESCO World Heritage Sites, signifying that they are a protected area of global significance.
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Geographically, parks in the province are divided into six regions and three cities:
Kootenay Rockies Epic parks encompassing 4 mountain ranges including the Rocky Mountains.
Cariboo Chilcotin Coast Home to spectacular wildlife viewing and the Bowron Lakes canoe circuit.
Thompson Okanagan Majestic waterfalls, glaciers, grasslands and the highest peak in the Canadian Rockies.
Vancouver Island Sprawling white sand beaches, tide pools, remote wilderness trails and old-growth forests.
Vancouver, Coast & Mountains Outdoor oasis with alpine meadows, lakes and mountains.
Northern British Columbia Two UNESCO World Heritage Sites, grizzly bears and unspoiled wilderness.
Vancouver Home to Stanley Park, the crown jewel of Vancouver, plus nature trails, gardens and getaways.
Victoria Wildlife viewing, birdwatching and excellent hiking trails along rugged ocean shoreline.
Whistler Family-friendly parks with beaches and lakes offer year-round outdoor recreation.
Pick from some of BC's most unique or interesting parks according to special interest below, or by the region/city (above). Or explore trip ideas about some family-friendly parks and provincial park highlights.
Looking for the great outdoors? Check out East Sooke Regional Park, near Victoria. Cape Scott Provincial Park or Haida Gwaii's Naikoon Provincial Park are perfect for adventure seekers. Pacific Rim National Park Reserve is famous for hiking, surfing, kayaking and beachcombing.
Boaters in the Pacific Northwest are drawn to Princess Louisa Marine Provincial Park, and Desolation Sound Marine Provincial Park. Canoe and kayak enthusiats flock to Bowron Lake Provincial Park Canoe Circuit and Broken Group Islands (Pacific Rim National Park Reserve).
Accessible only by floatplane for boat, Hot Springs Cove near Tofino is a popular day trip. Bishop Bay Hot Springs (Monkey Beach Conservancy) attracts boaters traveling the Inside Passage, while Lussier Hot Springs in Whiteswan Lake Provincial Park are famous for their spectacular natural setting.
Rugged mountain ranges dominate the landscape in BC. Northern Rocky Mountains Provincial Parks, along the Alaska Highway, provides a backdrop of mountains and wilderness. Kootenay National Park, Mount Revelstoke National Park, Glacier National Park and Yoho National Park all offer outstanding scenery. Mount Robson Provincial Park is home to the highest peak in the Canadian Rockies.
Alouette Lake in Golden Ears Provincial Park is ideal for all water activities. Whistler's Lost Lake Park and Vancouver Island's Rathtrevor Beach Provincial Park are summer favourites. Elk/Beaver Lake Regional Park in Victoria draw summer crowds.
Get an up-close look at Haida culture at Gwaii Haanas on Haida Gwaii. Nisga'a Memorial Lava Bed Provincial Park features a moonscape of volcanic rock and an intriguing look at Nisga'a culture and legends.
Birdwatchers will delight in Witty's Lagoon Regional Park and Island View Regional Park near Victoria. Visitors to Vaseux Lake Provincial Park in the Thompson Okanagan should watch for mountain goats, bighorn sheep and a variety of bird species.
To view salmon, head to Goldstream Provincial Park or Capilano River Park and Salmon Hatchery. To view one of the world's largest sockeye salmon runs, head to Roderick Haig-Brown Provincial Park, where every four years the Adams River turns red with fish (next run is in 2014).
Many parks offer camping facilities – both vehicle-access and wilderness sites. The typical camping season is mid-May to mid-September although opportunities also abound for winter camping. Some parks accept reservations, others don't. Check the specific park's listing. Campers in the backcountry should practice "leave no trace" ethics.
BC's parks are home to a rich and diverse variety of wildlife. For more information, including a wildlife viewing code of ethics, read the BC Parks Wildlife Guidelines.
Though animals typically avoid human interaction, bears may be encountered in some parks, especially in wilderness areas. Anyone venturing into the BC backcountry should be "bear aware"; read the BC Parks Bear Safety guidelines for more information.
Watch for signage, but dogs on leash are usually welcome in most city parks and off-leash areas are designated. In wilderness areas, pets are generally discouraged and sometimes prohibited because of problems with wildlife, bears in particular. Check the specific park's website to be certain.
While most parks are open year round, winter weather can close trails and make conditions treacherous. Visitors need to check trail conditions and ensure they are appropriately equipped and knowledgeable about the terrain and winter conditions. Check the specific park's website for trail conditions.
Play a part in protecting BC's forests. Abide by local park rules, exercise caution and ensure all fires are extinguished. For more information on BC forest fires, click here. To report a forest fire within BC from a cell phone, call *5555.
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Here is a photo of what they look like on the 6000. I took the extention pieces off and used the fenders on a hundred series tractor. I did get a nice pair of monkey grips on those fenders to use on one of my row crops.I took a quick look in the barn yesterday and didn't see the extentions. They might have hit the last scrap pile that when to the scrap yard but will check for sure again this week.My wife has been after me to clean up my tractor graveyard.
TRADEMARK DISCLAIMER: Tradenames and Trademarks referred to within Yesterday's Tractor Co. products and within the Yesterday's Tractor Co. websites are the property of their respective trademark holders. None of these trademark holders are affiliated with Yesterday's Tractor Co., our products, or our website nor are we sponsored by them. John Deere and its logos are the registered trademarks of the John Deere Corporation. Agco, Agco Allis, White, Massey Ferguson and their logos are the registered trademarks of AGCO Corporation. Case, Case-IH, Farmall, International Harvester, New Holland and their logos are registered trademarks of CNH Global N.V.


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After being unable to find a simple reference sheet for the Carpenters Wheel quilt, I decided to make my own. I hope others will find this useful. I have included an image and a pdf file, if you prefer. Enjoy. :D
*** Please Note: I did not included any measurements so that you may make the quilt (or other item) any size that works for you. :D
Carpenters Wheel / Star Project Reference Sheet JPG Format
Carpenters Wheel / Star Project Reference Sheet PDF Format


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JERUSALEM (AP) — Israeli police detained the top Muslim cleric in the Holy Land Wednesday in a rare crackdown on a leading religious figure, questioning him for several hours before releasing him without charge.
Later in the day, in the Gaza Strip, an influential Muslim cleric from Qatar received a hero's welcome in a high-profile visit that deepened the bitter division between Gaza's hardline Islamist rulers and the West Bank's Western-backed Palestinian leaders.
The detention of the mufti of Jerusalem, which followed recent unrest at a disputed holy site in Jerusalem, drew harsh condemnation from Palestinian leaders and neighboring Jordan and threatened to complicate U.S. Secretary of State John Kerry's latest effort to restart Mideast peace talks.
Police spokesman Micky Rosenfeld said mufti Mohammed Hussein was questioned for six hours in connection to "recent disturbances" on a hilltop compound in Jerusalem's Old City that is revered by Jews and Muslims. This included "incitement, disturbances and public disorder."
Hussein was released without being charged, Rosenfeld said. He did not elaborate, but another Israeli official said the Muslim cleric was issued a warning and told to lower tensions a day after Muslim worshippers threw rocks and chairs at tourists visiting the hilltop compound that houses the Al Aqsa Mosque.
The Israeli official spoke on condition of anonymity because he was not authorized to discuss the matter with the media. Hussein, who was appointed mufti in 2006, could not be reached for comment.
The compound is one of the region's most sensitive sites. It is revered by Jews as the Temple Mount, built above the ruins of the two biblical Jewish Temples. Muslims call it the Haram as-Sharif, or Noble Sanctuary. It is home to the Al Aqsa Mosque, the third holiest site in Islam, from which Muslims believe their Prophet Muhammad ascended to heaven. The iconic gold-topped Dome of the Rock sits next to the mosque.
The conflicting claims to the site lie at the heart of the Arab-Israeli conflict, and any acts seen as upsetting the delicate status quo risk setting off violence. Palestinians see visits by Israelis at the site as a provocation. Israeli steps to quell Palestinian disturbances there have led to riots in the past.
The mufti of Jerusalem is the top cleric in charge of Jerusalem's Islamic holy places, including the Al Aqsa compound. Hussein's predecessor, Ekrima Sabri, was detained for several hours in 2002, at the height of the Palestinian uprising against Israel, on suspicion of incitement for suicide attacks.
Hussein has been known as a relative moderate, with close ties to the Palestinian Authority in the West Bank. While Jordan, which controlled east Jerusalem before Israel captured it in 1967, remains the custodial authority over the Al Aqsa compound, the Palestinians appoint the mufti.
Palestinian President Mahmoud Abbas, who appointed Hussein, condemned his detention. "Arresting the mufti is a stark challenge to the freedom of worship," Abbas said in a statement released by the official Palestinian news agency Wafa.
The Jordanian foreign ministry also denounced the detention, and legislators demanded the kingdom's envoy be recalled from Tel Aviv.
The detention was a blow to Kerry's efforts to restart peace talks, which have been stalled since late 2008. The Palestinians have refused to negotiate while Israel builds settlements in the West Bank and east Jerusalem. The Palestinians claim both areas, captured by Israel in the 1967 Mideast war, as parts of a future independent state and say settlement construction must halt.
Kerry has been shuttling between the Israeli and Palestinian sides in recent weeks in hopes of finding a formula to restart talks. In Rome, he was meeting the chief Israeli negotiator, Tzipi Livni.
The incident occurred as Israelis marked Jerusalem Day, which commemorates the anniversary of Israel's capture of east Jerusalem. The city's eastern sector is home to the Old City, where key Jewish, Muslim and Christian holy sites are located.
About 300 Palestinians gathered for a Jerusalem Day protest waving Palestinian flags and scuffling with dozens of Israeli protesters. Israeli police spokesman Rosenfeld said police arrested 10 Palestinians for gathering in an illegal demonstration and causing public disorder.
There was heavy police presence to guard Jerusalem Day marchers in the parade scheduled to go past a Palestinian area of the Old City.
In the Gaza Strip Wednesday, influential Muslim cleric Yusuf al-Qaradawi arrived for his first visit to Gaza as a top cleric, making one of the most high-profile visits to the Palestinian territory since the Islamic group Hamas seized control in 2007.
Al-Qaradawi is a prominent scholar and Qatar-based cleric who is widely respected in the Muslim world, and his visit emboldens Hamas. Visits by leading figures have been rare in Hamas-run Gaza, and al-Qaradawi's trip is expected to help break the diplomatic isolation that Gaza has been under through years of blockades enforced by Israel and Egypt.
The emir of the Gulf state Qatar visited last year, and Turkey's Prime Minister Recep Tayyip Erdogan has announced his intention to visit later this month, despite a U.S. plea that he delay the trip so as not to harm efforts to broker a reconciliation between Turkey and Israel.
Prime Minister Ismail Haniyeh kissed al-Qaradawi's right hand upon his arrival, calling him "the grand imam of modern Islam and the grand imam of the Arab spring." Hundreds of Hamas supporters waved to his passing convoy.
"It is a great moment for me to meet with you, the people of Palestine, and all the components of Gaza society," al-Qaradawi said in a speech at a welcoming ceremony. But he also acknowledged that he was being hosted by just one part of what is a divided Palestinian society, saying that he hoped to meet with "all Palestinians" on his next visit.
On, Thursday he was scheduled to talk with Haniyeh and Hamas cabinet ministers, attend a demonstration for Palestinian prisoners in Israeli jails, visit the home of Hamas cleric Ahmed Yassin, who was assassinated in a 2004 Israeli airstrike, and address a public rally.
The rival Palestinian Authority government in the West Bank was angered by the visit, claiming it served to strengthen the Palestinians' bitter political division.
"Any visit that carries a political significance, that acknowledges the legitimacy of Hamas in Gaza, is considered harmful and against the interest of the Palestinian people," said Mahmoud Al Habash, minister of religious affairs in the West Bank.
There were mixed reactions to the cleric's visit in Gaza.
Palestinian faction leaders affiliated with the West Bank Palestinian leaders' secular Fatah party as well as heads of civil society groups refused to participate in al-Qaradawi's welcome reception. Among other things, they objected to what they said was the cleric's support of U.S. involvement in the Libyan uprising and the Syrian civil war.
"After he was rejected in most Arab countries for blessing the U.S. intervention in Libya and Syria ... it seems that this man is coming to Gaza to clean his record and seek indulgences," Gaza political analyst Ibrahim Abrash wrote on his blog.
Also Wednesday, Israel released two Palestinian prisoners of the Islamic Jihad militant group who were waging three-month long hunger strikes in Israeli custody. An Associated Press photographer witnessed Tarik Qadan, 40, and Jafar Izzideen, 47, being released from custody. They reached a deal with Israel by which their six-month detention would not be renewed. Israel's army said the release was for humanitarian reasons.
Associated Press writer Mohammed Daraghmeh in Ramallah, West Bank, Jamal Halaby in Amman, Ibrahim Barzaq in Gaza City, Gaza Strip, and Daniel Estrin in Jerusalem contributed to this report.


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Summer Solstice Sipper
Summer Solstice Sipper
By Tiffany Friday, Bartender, TASTE at The Seattle Art Museum
A refreshing fruit-laced summer cocktail, this drink gets beautiful color and distinctive flavor from the muddled strawberries and bits of sweet basil.
- 2 parts Maker's Mark® Bourbon
- 1-1/2 parts ginger beer
- 1-3/4 parts lemon juice
- Large strawberry (or 3 small)
- 4 basil leaves
- 1 dash Fee Brothers™ Rhubarb Bitters
- Strawberry slice for garnish
- Muddle strawberries and basil well.
- Add rhubarb bitters, lemon juice and Maker's Mark® Bourbon.
- Add ice and shake.
- Strain over ice in a highball glass.
- Add ginger beer and stir lightly.
- Garnish with a slice of strawberry.
Tags: Cocktails, Muddled, Summer Solstice Sipper, Ginger Beer, Lemons, Strawberries, Basil, Rhubarb Bitters, Thirsty


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Free Internet access now available throughout Minneapolis
In its continuing efforts to bridge the digital divide, the City of Minneapolis announced on Friday, June 25 that residents and visitors will now be able to access the Internet for free from 117 "Wireless Minneapolis" hotspots throughout the city. These hotspots are one of the many community benefits that resulted from the City of Minneapolis' contract with USI Wireless, the company that built the wireless network blanketing the entire city.
When connected to one of these hotspots, folks will be able access any website on the Internet for up to one hour. After one hour, a user's session will end; however, the user can log-in again to continue accessing the Internet. A credit card number will be required to access the Internet from a "Wireless Minneapolis" hotspot for homeland security purposes but the credit card will not be charged.
In selecting the locations for the 117 "Wireless Minneapolis" hotspots, the City looked for places where people already gather and use computers, and places where free wireless access would encourage people to gather, including parks, plazas, schools, and businesses. Hotspots will be clearly marked with signs that say, "Free Wireless Minneapolis Hotspot Courtesy: City of Minneapolis USI Wireless." The free wireless signal will be available up to 600 feet from the sign.
In addition to the 117 hotspots, the City of Minneapolis and USI Wireless also offer free "Wireless Community" accounts to nonprofit organizations that provide free computer access to the public, and an online "Civic Garden" that provides a free level of service for anyone who can receive the USI Wireless signal. The Civic Garden offers free access to a wealth of public sector information about government, education, and community services.
In 2006 the City of Minneapolis signed a 10-year contract with USI Wireless of Minnetonka to provide Minneapolis with cutting-edge broadband technology. USI Wireless is a private company that owns, built and manages the wireless network, making Minneapolis one of the first large cities in the United States to go wireless. The network is allowing the City to deliver services more efficiently and effectively than ever before.
Published Jun 25, 2010


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Search terms
Plug-in charging dock
Give your iPhone or iPod a safe, secure place to charge. The unique cushion-top design provides support without the need for clumsy fit inserts. In the office, bedroom, kitchen - anywhere you need a convenient, cable-free charging solution. See all benefits
Unfortunately this product is no longer available
Don't sit around waiting for your device to charge! The higher power output of this charger ensures your device is fully charged in a shorter amount of time compared to standard, less powerful chargers.
The cushioned top supports your iPhone or iPod without the need for fit inserts, keeping your area neat and clutter-free. It also hides the connector when not in use for a discreet, attractive charging solution.
The 30-pin dock connector itself pivots which allows your device to simply rest backwards against the support without the need for clunky cradles or fit inserts.
The wall-mounted dock gives your iPhone or iPod a save and secure place to charge. Simply plug the dock into the wall to cradle your iPod or iPhone - this gets your iPod or iPhone up off the floor where it could be stepped on, and up out of the way of spills and countertop messes.
Plugging your device into a cable-based charger and leaving it on the floor or countertop puts your iPod or iPhone at risk of being stepped on or damaged from spills and splashes. Instead, using a wall-mounted charger elevates your iPod or iPhone for safe and secure charging.
In the office, the bedroom, the kitchen - WallDock easily plugs in anywhere you need a convenient, cable-free charging solution. Plus, it's small enough to take it with you when you travel so you're ready to dock and charge when you arrive.


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Hawkshead Grill Sauce - 230 ml bottle - Lake District, England This tasty sauce is new for the award winning Hawkshead Relish Company. It is a very, very tasty, tomato-based steak sauce - not oozing, indistinguishable brown or orange like the big boys make. It is tangy - thanks to the tomatoes, tamarind and a touch of malt vinegar - with a nice finish of sweetness - that's the molasses - and just a pinch of heat - from horseradish. It is great for burgers or chops and it will enhance any dogs, burgers or brats that come from your grill. About the Producers The Hawkshead Relish Company is small, family-run artisan food business based in rural Cumbria, in England's Lake District. Although small, they have already taken home more than 30 "Great Taste Awards" for their relishes, pickles and preserves. Learn more about the Hawkshead Relish Company
ingredients: Sugar, Acetic Acid, Tomato, Hawkshead Relish (Water, Acetic Acid, Treacle, Sugar, Tamarind, Garlic, Salt, Balsamic Fruit Vinegar, Cayenne, Caramel, Cloves), Cornflour, Horseradish, Salt, Smoked Pimenton, Cayenne
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Man sentenced for robbing Market BasketBy JAMES A. KIMBLE
Union Leader Correspondent
September 17. 2013 10:06PM
BRENTWOOD — A Somersworth man was sentenced to 1½ to 4 years in state prison for robbing a Market Basket in Epping by handing a threatening note to a clerk and running off with a handful of cash.
Eric Dubois, 32, pleaded guilty to a robbery charge as part of a negotiated plea deal with county prosecutors in Rockingham County Superior Court.
Had he been convicted at trial, Dubois could have faced up to 3½ to 7 years in prison.
A judge ordered Dubois to undergo alcohol and drug treatment as part of his sentence.
He is also barred from having any contact with the female employee that he threatened at the Route 125 grocery store, a judge decided.
Prosecutors said Dubois went to Market Basket on Feb. 9 and passed a note telling the clerk that if she did not get him any money, "I will start hurting people, starting with you."
Dubois fled with roughly $163 in cash, and took off in a car that he later crashed on Route 125 in Rochester.
A store manager was able to get the license plate from the car, prompting police to issue a bulletin to area police departments, prosecutors said.
A Barrington police officer spotted Dubois' vehicle after the robbery. But Dubois fled from police until he crashed his car. He was arrested at the scene. Police recovered almost all the money — $158 — from the car.
Dubois is expected to apply to have a related case in Strafford County regarding the car crash heard in its drug court, according to court records.
He faces charges of reckless operation, reckless conduct, disobeying a police officer and driving after suspension in connection with the crash.
Dubois admitted during a police interview that he passed the threatening note and claimed to be going through tough financial times.
Police recovered evidence linking Dubois to the robbery, including a blue hooded sweatshirt he allegedly wore and a piece of an inspection report that was used to make the note.
He has already spent 68 days behind bars following his arrest.


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Shiv Sena original aam aadmi party: Uddhav Thackeray
Mumbai, Jan 6 (IANS) Shiv Sena is the original aam aadmi party from the days it was founded by Bal Thackeray, party president Uddhav Thackeray said here Monday.
"The Maharashtra voter is a common man – Balasaheb (Thackeray) always took the aam aadmi with him in his political career. So the common man in Maharashtra has always been with Shiv Sena," he told media persons in response to queries about the possible impact of Aam Aadmi Party (AAP) in state politics in the April-May Lok Sabha elections.
Since the common masses have always been with the Shiv Sena, it is not worried about any other party, he added.
A senior party official later said that Thackeray's statement referred only to the AAP which is planning to contest elections in Maharahstra and not to the Shiv Sena's allies or other like-minded parties.
"He rightly said that the Shiv Sena is a party of the commoners – we have had vegetable or vada-paav vendors, ticket or flower sellers and other common people from society who made it big in politics and public life thanks to Bal Thackeray," the leader said.


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There's no better place to learn the sport of
cross country skiing than here at Lapland Lake in the
Adirondacks! Our Professional Ski Instructors of
America (PSIA) certified Ski School offers quality
instruction to everyone from the very first-timer to racers
seeking to refine technique.
Lapland Lake has spent years assembling what we feel is one of
the best group of
professional cross country ski instructors
around, and we are fortunate to have them with us! Our 15
job-sharing PSIA-certified instructors have 115 years of combined teaching experience
among them, an average of more than 7 years per person, with all of those years right here
at Lapland Lake! They are
superb skiers, patient, dedicated, excellent communicators and,
quite simply, nice folks! They'll have you on your way in no time at all!
All adult lesson participants receive
a Skier Achievement Card that your instructor will use at the end of the lesson to provide individual feedback regarding skills you have accomplished and which skills are yet to be mastered. By displaying the Skier Achievement Card at our
Kuuma Feeding
Station, you will receive one free hot coffee, tea or hot
Intro to Skate Skiing
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Police say man failed to appear in court in August
Fugitive accused of sexual assault arrested in Puerto Rico
Police say man failed to appear in court in August
Members of the U.S. Marshals Fugitive Task Force have arrested a man in Puerto Rico wanted in connection with a rape case in New Hampshire.
Francisco Vidal was arrested Thursday night in Cayey, Puerto Rico, about 40 miles south of San Juan. He was wanted on an outstanding warrant for failure to appear in Hillsborough County Superior Court in August.
Vidal was indicted on a charge of aggravated felonious sexual assault involving a child under age 13. Police said the offense happened in Manchester.
The arrest was a cooperative effort of the U.S. marshals in New Hampshire, Massachusetts and Puerto Rico, with support from the Hillsborough County Sheriff's Office.


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Good news for Elvis, it appears that blue suede shoes (and leather ones too) are enjoying a bit of a mini revival. I saw that Clarks had added navy to its range of classics this year and they are not alone. You can also buy blue suede and leather brogues and loafers too. Of course you have to be a …
Clarks Originals Desert Boot goes metal
Click to enlarge
The Desert Boot is a design classic and is one of those items which never really goes out of style. I recently saw a well-dressed chap on the street sporting a suede pair with some tracksuit-bottom style cuffed trousers and it made a great outfit.


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West Allis woman claims $1 million Powerball
West Allis woman claims $1 million Powerball
West Allis —
A West Allis woman has claimed a $1 million dollar Powerball prize.
In a statement released Friday, Mary Retterath said she was overcome by the moment when she learned she was officially Wisconsin's newest millionaire.
Retterath and her husband Dennis brought their winning ticket to the Lottery's headquarters in Madison where it was validated.
Retterath purchased her Quick Pick ticket at the Speedway at 9130 W. Oklahoma Ave.
It matched all five regular winning numbers but not the Powerball.
After taxes, Ratterath received $672,500.
Retterath and her husband are expected to talk about their good fortune at a news conference on Monday at West Allis City Hall.


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Starter: Raisin water does not ferment - it moulds - help
During the winter I made a fantastic starter with fermented raisin water. Water & Raisins 10 days later it was foaming and boozy. The result giving us a starter with really great bakes.
My daughter (9) is making a starter as a project. It has changed the water colour as expected but is not foaming, it is not boozy it has grown mould on top.
The only two things that I can think of is the difference in temperature during winter and early summer and the type of produce. My starter was made with off the shelf raisins, flower and tap water while hers is made with Organic ingredients and spring water.
As you can see on the photo all was honky doory on day 3 – 4 and then it just went down hill until it went mouldy on day 8 – 9.
Please help.
1. Please confirm the root of the problem.
2. Please give me suggestions/pointers on how to fix this dilemma in future.
Thank you


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In 1911 Marie Curie was awarded the second of her two Nobel Prizes, both connected to her discovery of radium. The radioactive element was initially hailed as a miracle substance, credited with curing cancer and other ailments, its deadly nature lurking invisibly beneath its luminescent glow.
Beginning in 1917, the U.S. Radium Corporation manufactured glow-in-the-dark watch and clock faces and instrument dials at its factory in Orange, N. J. Young women daubed the dials with radium-based paint. Unlike many factories of the period, the studio they worked in was light and airy, the work was not arduous, and the pay was comparatively good for women's wages at the time. They were not warned of any risk and were even told to lick the tips of their brushes to keep them sharp for the exacting work.
Before long, the workers began developing symptoms of what later would be recognized as radiation poisoning: anemia, bleeding gums, necrosis of the jaw, bone cancer. And here's where the story starts sounding pretty familiar.
The company denied any connection between the women's illnesses and their work, even claiming the symptoms were due to syphilis, undercutting their complaints and impugning their morals in one stroke. Executives falsified reports, withheld information, hired doctors to supply false diagnoses and lawyers to stonewall or arrange piddling cash settlements with non-disclosure/no-liability clauses.
When Grace Fryer and four young coworkers decided to sue their employer, it took them two years to find a lawyer willing to take their case on contingency. The corporation gamed the legal system, dragging out the process in the expectation that the plaintiffs, dubbed "Radium Girls" in the press, would exceed the statute of limitations or die before they got their day in court.
Although the case was ultimately settled by U.S. Radium rather than going to trial, it established a number of precedents in labor and tort law and forced improvements in occupational safety regulations. It also demonstrated the power of the press. The Radium Girls' plight, related by "sob sister" reporters in local and national tabloids, became a major human interest story and turned the spotlight on the corporation's activities.
Average girls
"It's good to know this kind of thing doesn't happen any more," says Robert Freedman with a wink. He's the director of Radium Girls, a play by D.W. Gregory that dramatizes the case. Produced by Arena Civic Theatre, it runs through this weekend at the Shea Theater in Turners Falls.
When I spoke with Freedman before a dress rehearsal last week, he acknowledged the historical connections to more recent corporate shenanigans involving toxic chemicals (think dioxin and PCBs). The case also highlights parallels between scientists' early celebration of radium as a miracle cure and other medical marvels with tragic side effects (think thalidomide, a treatment for morning sickness that caused horrible birth defects). But Freedman's interest in the story and the play revolves primarily around its personalities: "I was interested in why these young 'nobodies' decided to take on a corporation" (think Erin Brockovich).
"It's the story of average girls who went to work and were happy to have the job," he told me. "They didn't question anybody. They did what they were told. Painting the watch dials was very delicate and precise work, and the girls considered themselves artists. The corporation knew there were major potential hazards with this substance, but for whatever reason they didn't tell the girls. They actually encouraged them to put the brush tips in their mouths."
In his research while preparing his production, Freedman learned that this work, and the resulting illness and contamination, was not limited to the U.S. Radium factory in Orange but affected thousands of workers across the country, mostly women, many of whom died. Those factories have since been identified as Superfund hazmat cleanup sites. He also discovered an ironic twist to the story. The work that was killing the young women was touted as a patriotic contribution to the war effort. The luminescent watches were worn by soldiers in the trenches of World War I, so they could check the time without striking a light and exposing their position.
Gregory's episodic docudrama covers a 10-year period and fields a cast of almost 30. While the playwright sticks closely to the historical facts, she takes dramatic liberties with some of the characters. Where the history shows that U.S. Radium's executives knew of the dangers early on—and protected their lab technicians, but not the dial painters, from radiation—the play's depiction of the company's CEO, Arthur Roeder, is more nuanced. Played here by Jim Lobley, he's a conflicted figure. At first ignorant of radium's lethal potential, even sharing glasses of "invigorating" Radium Water with his wife, he becomes a reluctant collaborator in coverup and defiance.
"It's a gradual progression to the dark side," Lobley told me. "At each point, one decision after another after another, he's struggling with the feeling that it's not what he wants to do, but for one reason or another it seems to make sense at the time. From scene to scene he's getting further in and struggling to get out."
Jen Campbell, who plays Grace Fryer, the prime mover in the Radium Girls case, sees not only the small fry's struggle against the Goliath corporation, but a young woman's coming of age: "There's her awareness that something 'just ain't right,' as she would say, then also realizing what kind of power is in her own life. She's constantly realizing and discovering and battling."
Grace's story is also the story of an ordinary person longing for an ordinary life but caught up in extraordinary circumstances. "She wants to get married, she wants to have kids, she's found a good guy—that's all she wants," Campbell said. "I like the idea of a young woman from her generation who wanted to follow the rules so bad, and was put in this life where she couldn't in good conscience follow the rules."
Radium Girls plays at the Shea Theater, 71 Avenue A, Turners Falls, April 27-28 at 8 p.m. and April 29 at 2 p.m. Tickets (413) 863-2281, arenacivictheatre.org or at the door.
Contact Chris Rohmann at email@example.com.


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Hoboken-based John Wiley & Sons, a global provider of knowledge-enabled solutions, announced Friday that its board of directors has declared a 16 percent increase in its quarterly dividend.
The dividend of 29 cents per share on its Class A and Class B stock will be payable July 16 to shareholders of record as of July 1.
The dividend is a 16 percent increase compared with the previous dividend of 25 cents per share. This increase marks the 21st consecutive year that Wiley has raised its dividend.
In addition, Wiley repurchased 1.25 million shares for $63.4 million. As of the end of April, the company had approximately 3.3 million shares remaining in its repurchase program.
13 arrested in medical kickback scheme that generated hundreds of thousands in profit
Saint Peter's center is latest higher ed project built with an eye toward neighborhood renewal
Revel Casino owners file for bankruptcy again


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After flatlining in December, discount giant Target (NYSE:TGT) said Thursday its same-store sales leaped 3.1% in January and nearly doubled Wall Street's expectations due to a strong appetite for clearance items.
Continue Reading Below
Shares of the Minneapolis-based company ticked slightly lower during early trading.
In its final monthly sales release, Target said its net sales soared 29.6% in January to $5.97 billion.
Closely-watched same-store sales rose 3.1% last month, compared with forecasts from analysts for a 1.7% increase. That marks an improvement from December when Target's same-store sales were essentially flat due to "softness" before the Christmas holiday.
"January comparable-store sales were in line with our expectations as guests responded to clearance prices on holiday inventory," CEO Gregg Steinhafel said in a statement.
However, Target said it remains focused on offering customers superior values amid the continued sluggish economy.
"Our guests continue to shop with discipline in the face of a slow economic recovery and new pressures, including recent payroll tax increases," Steinhafel said.
As previously announced, Target said Thursday marked the release of its final monthly sales report. While many retailers like Macy's (NYSE:M) report monthly sales, some like retail giant Wal-Mart (NYSE:WMT) have discontinued the process.
Shares of Target slipped 0.20% to $62.56 Thursday morning, largely maintaining their 2013 rally of about 5.8%.


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I've been playing around with a handy tool for creating Word and Excel files called OfficeWriter that's pretty impressive. Basically, you use Excel or Word to create templates utilizing data markers and merge fields which allow you to databind sections of the document to a data source. It's almost like writing a databound ASP.NET page, only you are using Word or Excel instead of HTML ... a pretty neat idea now that I think of it. Then, using their libraries installed on your server, your ASP/ASP.NET applications can generate documents/spreadsheets based on these templates without the need for Microsoft Office on the server. I've just started to explore the features, but it makes creating Microsoft Office documents programmatically pretty simple and it's quite flexible in the options provided. Their library seems to include pretty much all of the document manipulation methods that you need, and all without creating Word/Excel COM objects on your server.
There's also an integration with Reporting Services that will let you create these documents without any coding at all. Users design RS reports with Excel and Word and don't have to understand Visual Studio or SQL Report Builder. I've only scratched the surface so far, but it seems that they've pretty much thought of every way you'd ever want to generate an Office document and they've got it covered!
Overall, it's definitely something worth looking into if you need any of these features. You can check it out here: http://officewriter.softartisans.com
Print | posted on Tuesday, July 18, 2006 3:05 PM |
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Interested in having me film a promo video for your organization? Please contact me!


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Does this sound like your life recently?
- You were raised to believe that you should own your own home, but after having some hard times, the mortgage company turns down your loan modification and you find yourself in danger of losing your house to foreclosure.
- You got two months behind on your car or truck payments, now the finance company wants all the money and you don't have it. They are threatening to pick up the vehicle if you don't pay it all now.
- You lose your job or overtime, and you have to use credit cards to make ends meet. Now they are "maxed out" and you have no way to pay your bills.
- You were always told about the benefits of getting an education, but now you are unemployed or underemployed and in default on your student loans. You can't pay them back as fast as the debt collectors demand and they are calling constantly.
- As a last resort you've taken out payday loans, now you are drowning in debt and they call every day.
Getting buried in debt is an all-too-common occurrence for many people in Texas. Attorney J. Thomas Black wants to help you dig yourself out. Mr. Black is Board Certified in Consumer Bankruptcy Law by the Texas Board of Legal Specialization.
He will listen to you and show you the options that you have to choose from in your situation to either discharge, settle, or reorganize your debts.
Debt Comes in Many Forms
Whether you are in the beginning stages of realizing that your debts are getting to be too much, or you're at the end of your rope, sick of harassing calls from collection agencies, and ready to get a bankruptcy case started, Mr. Black can help. With over 30 years of experience, he specializes in many different forms of debt troubles and ways to get it under control:
- Chapter 7 Bankruptcy
- Chapter 13 Bankruptcy
- Dealing with Overwhelming Credit Card Debt, Lawsuits and Judgments
- Debt Relief Settlements and Negotiations
- Dealing with Foreclosure and Repossessions
- Dealing with IRS Collection Problems
- Help with Student Loan Collection Problems
- Getting your credit score to 720 or higher within 1-2 years after bankruptcy.
Don't Be Afraid of Bankruptcy in Texas
The idea of filing for bankruptcy terrifies a lot of people because they think it means they are going to lose everything; the reality is quite the opposite. If you file Chapter 7 bankruptcy, bankruptcy law allows you to keep your exempt property, which—for most people facing the prospect of filing bankruptcy in Texas—is most or all of their property. You still must pay any valid liens on the property.
With Chapter 13 bankruptcy, a debtor proposes a plan to repay creditors either partially or in full over a three- to five-year period. During that time, the debtor can make up overdue payments on her home, "modify" car and truck loans to make them more affordable, pay or "discharge" or cancel delinquent IRS debt and pay into the plan the equivalent value of any assets not covered by exemptions.
Chapter 13 is best suited for someone with a regular source of income because it requires monthly or biweekly payments. Mr. Black will be able to let you know if this is a good choice for you and show you how a Chapter 13 plan would work in your particular circumstances during your first free consultation with him. Not yet ready for a consultation? Request some of Mr. Black's free information.
Your Fresh Start Begins Now
Congratulations! You have already started doing research about getting your debts under control, and that is a huge first step. The Law of Office of J. Thomas Black will take you from that first step forward toward financial freedom, or at least toward getting control of your debt problems.
Mr. Black does not just "dabble" in bankruptcy law; it is his life's work and his area of expertise. Along with his board certification, Mr. Black is an author and speaker on bankruptcy issues, and he is very active in the bankruptcy community. His extensive qualifications can be found on his biographical page.
During your free first consultation, we will listen to your financial concerns and review your options with you. Once you choose an option and decide to move forward, Mr. Black and his staff will be there to put those plans into action and start proceedings that will get your life back on the right track.
When it comes to credit card debt, lawsuits, repossession, foreclosure, student loan and IRS collection problems, you need competent and experienced legal help and advice. Contact Mr. Black's office to arrange your free consultation with him. You can schedule it on this website, or by calling his Houston number 713-772-8037 or toll free at 888-707-1233.


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Bethany Joy Galeotti & Husband Divorcing
Bethany Joy Galeotti has announced that she and her husband, Michael, are divorcing after six years of marriage.
"I'm sorry to say that Michael and I have decided to divorce," the 30-year-old One Tree Hill actress wrote on her blog on Monday.
"We remain friendly and dedicated to raising our beautiful girl in love and we appreciate your prayers and support during this difficult time," she continued. "I feel immensely humbled and grateful that God works all things for the good of those who love Him."
Bethany and Michael became parents to a little girl, Maria, in February of 2011.


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May 04, 2010
In Fairbanks Superior Court April 19, Gareth Demoski, 22, learned his fate for committing seven different crimes, including two counts of sexual assault in the first degree and two counts in the second degree, involving conduct against two different victims, both of whom were intoxicated and asleep.
Assistant District Attorneys Sara Simpson and Renner Eberlein argued that despite Demoski's young age he remains extremely dangerous. Judge Olsen concluded that Demoski lacked empathy for his victims and sentenced him to 58.5 years in prison, with 20 years suspended and 15 years of probation. The time-to-serve of 38.5 years is five years more than recommended in the presentencing report.
Last month, a Kotzebue jury convicted James Phillips of 13 felonies, seven counts of which were sexual assaults in the second degree and sexual abuses of a minor in the third degree, involving four teenage girls on four separate occasions. Prior to trial the defendant pled no contest to one misdemeanor count of failure to register as a sex offender.
"The defendant has five prior rape and rape-related convictions from Oklahoma and Kansas and should be subject to the mandatory 99-year minimum sentence," said Rick Svobodny, deputy attorney general for the criminal division of the Department of Law. "With tough new laws, and with Governor Parnell's commitment to ending the epidemic of sexual violence in Alaska within 10 years, we've put potential offenders on notice that if they commit these crimes they might well end up in prison for the rest of their lives."
Source of News:
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38 U.S. Code § 512 - Delegation of authority; assignment of functions and duties
§ 512.
Delegation of authority; assignment of functions and duties
Except as otherwise provided by law, the Secretary may assign functions and duties, and delegate, or authorize successive redelegation of, authority to act and to render decisions, with respect to all laws administered by the Department, to such officers and employees as the Secretary may find necessary. Within the limitations of such delegations, redelegations, or assignments, all official acts and decisions of such officers and employees shall have the same force and effect as though performed or rendered by the Secretary.
(Added Pub. L. 102–83, § 2(a), Aug. 6, 1991, 105 Stat. 389.)
Prior Provisions
Prior section 512 was renumbered section 1512 of this title.
Provisions similar to those in this section were contained in section 212 of this title prior to repeal by Pub. L. 102–83, § 2(a).
LII has no control over and does not endorse any external Internet site that contains links to or references LII.