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Leukemia cells, like most cancers, are addicted to glucose to generate their energy, but new research shows for the first time that these cells also rely on fatty acid metabolism to grow and to evade cell death.
Inhibiting fatty acid oxidation makes leukemia cells vulnerable to drugs that force them to commit suicide, scientists from The University of Texas M. D. Anderson Cancer Center and The University of Texas Medical School at Houston report in the January edition of the Journal of Clinical Investigation.
"These findings translate to a potentially transformational approach to controlling leukemia and cancer cell metabolism by therapeutically targeting fatty acid oxidation," said co-senior author Michael Andreeff, M.D., Ph.D., professor in M. D. Anderson's Department of Stem Cell Transplantation and Cellular Therapy.
"Cancer metabolism has attracted renewed, cutting-edge research interest," Andreeff said. "Here we have first identified a metabolic target and our first in vivo results are promising, but there is much more work that needs to be done."
Andreeff and co-senior author Heinrich Taegtmeyer, M.D., D.Phil., professor in the University of Texas Medical School Division of Cardiovascular Medicine, are collaborating to develop drugs based on their research results.
"The leukemia cells' appetite for fat seems to be formidable," Taegtmeyer said. "More importantly, fat oxidation seems to promote leukemia cell survival. Conversely, shutting off fat oxidation makes the cells vulnerable to self-destruction. If these initial results hold up, inhibitors of fat oxidation may become a new way to treat leukemia patients."
In normal cells, the processing of fatty acids in the cell's power-generating mitochondria leads to production of ATP, a molecule that serves as the major source of energy for the cell. The researchers showed that fatty acid oxidation in leukemia cell mitochondria drives cellular oxygen consumption and inhibits the activity of proteins that are vital to apoptosis, the programmed death of defective cells that begins in the mitochondria.
For energy generation, leukemia cells rely on glycolysis, the processing of a glucose molecule in the cellular cytoplasm that produces two molecules of ATP and two of pyruvate. Pyruvate, in turn, is converted to energy by the Krebs Cycle, a series of chemical reactions inside the mitochondria.
In a series of lab experiments, the researchers demonstrated that etomoxir, a drug used to treat heart failure, inhibits the growth of leukemia cells in culture in a dose-dependent manner. They also found that etomoxir sensitizes leukemia cells to drugs that cause apoptosis. The fatty acid synthase/lipase inhibitor orlistat also sensitized leukemia cells to programmed cell death.
Etomoxir treats heart failure by switching the heart's energy supply from fatty acids to pyruvate, which is more efficiently converted to energy by the mitochondria.
Mouse model experiments showed that combining etomoxir with the apoptosis-inducing drug ABT-737 or with cytarabine, a frontline drug for acute myeloid leukemia, reduced the leukemia burden and increased median survival time by 33 percent and 67 percent respectively compared to control group mice.
Additionally, etomoxir was found to decrease the number of quiescent leukemia progenitor cells in half of blood samples taken from acute myeloid leukemia patients. These quiescent cells are important, the researchers note, because they are capable of initiating leukemia and are highly resistant to traditional chemotherapy.
"Our findings suggest that mitochondrial function and resistance to apoptosis in leukemia cells are intimately linked with the entry of fatty acids into mitochondria," said first author Ismael Samudio, M.D., a fellow in Stem Cell Transplantation and Cellular Therapy. "For many years it has been apparent that leukemia cells are addicted to glucose for the generation of cellular energy (ATP). Now our results suggest that leukemia cells are addicted to fatty acids for the function of the Krebs cycle and the prevention of cell death."
Research was funded by a Young Investigator Award from Leukemia Texas to Samudio, the Paul and Mary Haas Chair in Genetics held by Andreeff and by grants from the National Cancer Institute and the National Heart, Lung and Blood Institute.
Samudio is now associate professor in biochemistry at the Universidad Javeriana in Bogota, Colombia. Co-authors with Andreeff, Taegtmeyer and Samudio are Michael Fiegl, M.D., Borys Korchin, M.D., Ph.D., and Seshargiri Duvvuri of M. D. Anderson's Department of Stem Cell Transplantation and Cellular Therapy; Romain Harmancey, Ph.D. of the University of Texas Medical School Division of Cardiology; Hagop Kantarjian, M.D., and Marina Konopleva, M.D., Ph.D., of M. D. Anderson's Department of Leukemia; and Kumar Kaluarachchi, Ph.D., and William Bornmann, Ph.D., of M. D. Anderson's Department of Experimental Therapeutics.
About M. D. Anderson
The University of Texas M. D. Anderson Cancer Center in Houston ranks as one of the world's most respected centers focused on cancer patient care, research, education and prevention. M. D. Anderson is one of only 40 comprehensive cancer centers designated by the National Cancer Institute. For six of the past eight years, including 2009, M. D. Anderson has ranked No. 1 in cancer care in "America's Best Hospitals," a survey published annually in U.S. News & World Report.
Scott Merville | EurekAlert!
Further information:
Further reports about: > ATP > Cancer > Cellular > Cellular Therapy > Medical Wellness > Stem cell innovation > Texas > Transplantation > acute myeloid leukemia > blood sample > cell death > fatty acid > heart failure > leukemia > leukemia cells > myeloid leukemia > therapy
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For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
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For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
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Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
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Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
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A lot of questions have been raised personally to myself and I am sure many are wondering what Bitcoin could be all about since for the last couple of months business news all over the world have been focusing on how this currency has been appreciating in value exponentially a surprising phenomenon which has never happened to the other commonly known currencies such as the Dollar and the Sterling Pound.
Each and every country in the world has their own currency which is used in day to day transactions. In Kenya we have the Shilling, South Africans have the Rand, Nigerians have the Naira and the United States have the might Dollar which is widely used all over the world in many transactions including forex. We exchange money in banks or other specialized foreign exchanges platforms, transfer it worldwide either through making purchases online or even invest it.
It is now interesting to see the rise of what we now call a digital currency such as Bitcoin or Etherum. Interest has grown over the past years because of the significant increase in value of the currency which is quite "abnormal" to understand.
Origin of Bitcoin
So where did this currency come from? This is probably the question you are asking yourself right now. Well, I may not have the exact answer to your question but it is believed in 2009, an unknown programmer called Satoshi Nakamoto came up with the proposal of creating a digital currency different from the 'normal' currencies popularly to be known as cryptocurrency.
This currency functions in almost the same way as the regular currencies since it has the ability to be a store of a value and can be used as a means of exchange. Just like the other currencies, cryptocurrencies have a market price and also has demand.
The only major difference a cryptocurrency has to a regular currency is that it intangible. There are no bank issued notes or papers meaning that it is impossible to use them in hand-to-hand transactions like buying of groceries in our local open air markets or kiosks.
How Bitcoins work
Bitcoins are normally stored and exchanged digitally within a network. Unlike the commonly used currencies where when funds are being transferred from one account to another a middleman is required i.e. banks to be specific, Bitcoins operate differently in that no intermediary is needed to make these transactions possible.
The issue, value and fiscal policy is normally controlled by the centralized authority such as the Central Bank of a country which builds trust but it is a different story with Bitcoin since the trust comes from the forces of cryptology.
Because of the lack of a central issuing body, Bitcoins are therefore created and transferred with the help of a unique process called 'mining' The mining process requires a powerful computer and a specific mining machine that work out the complex and technical cryptological functions which are billions of calculations.
Strengths and Weaknesses of Bitcoin
Bitcoin being the first digital currency which actually is uncontrolled, the currency is created at a fixed and predetermined rate meaning that it is immune from inflation. Another unique property of Bitcoin is that despite its transactions made public through the blockchain, all the actors involved in a transaction are only identified by their bitcoin wallet.
Lost? A Bitcoin wallet is just like the normal wallet people use to keep their money but it contains a unique address that enables a user to transact with another user thus a user stays anonymous.
Bitcoin is also unique in the way that it creates other strengths from the users perspective- its digital nature makes it highly divisible and the lack of a central body to regulate it ensures the transactions fees are not available.
Its nature and lack of the central regulatory body also shapes out its weaknesses as lost Bitcoins are non recoverable meaning if you loose your private key or the hard drive with your wallet then the coins are lost for good.
Bitcoin and the Future
The future of Bitcoin is not clear at the moment because of the restrictions imposed by governments in different countries and also its unstable exchange rates. However, current users are embracing it as an innovative concept and are contributing to establishing a global bitcoin economy.
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The hexadecimal color code #02b838 is a medium dark shade of green. In the RGB color model #02b838 is comprised of 0.78% red, 72.16% green and 21.96% blue. In the HSL color space #02b838 has a hue of 138° (degrees), 98% saturation and 36% lightness. This color has an approximate wavelength of 545.85 nm.
I saw the angel in the marble and carved until I set him free.

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To send light into the darkness of men's hearts - such is the duty of the artist.

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The aim of art is to represent not the outward appearance of things, but their inward significance.

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Find the perfect place from the worlds best selection of vacation rentals on HomeAway.
Our 2018 property listings offer a large selection of 22 vacation rentals near Frostproof. From 8 houses to 5 villas, find a unique house rental for you to enjoy a memorable stay with your family and friends. The best places to stay near Frostproof for a holiday or a weekend are on HomeAway.
HomeAway offers a large selection of vacation rentals near lovely places in Frostproof. From HomeAway travelers, the most popular points of interest to stay for a holiday trip or just for a weekend are:
But there are many other points of interest around Frostproof listed on HomeAway where you can find your place to stay. Please use our search bar to access the selection of vacation rentals available near the point of interest of your choice.
Yes, of course. HomeAway has 8 houses in Frostproof. Our other popular types of vacation rentals in Frostproof include:
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The lake, forests and wildlife display a scene truly unique to Frostproof. This quaint city is known for its golfing, musicals and opera houses. Consider a vacation rental for your stay. Many offer full kitchens and spacious living quarters, along with cable or satellite TV and DVD players to entertain you on a lazy day.
First time in Frostproof and looking for things to do? Visitors searching for nearby cultural experiences can spend an enlightening afternoon at Depot Museum, Children's Museum of the Highlands or Highlands Little Theatre. To appreciate the outdoor scene, make time for beaches like Veterans Beach and green spaces such as Donaldson Park and Durrah Martin Complex. Activities around the area include River Greens Golf Course, Highlands Ridge Golf Course and Pinecrest Golf Club. Highlands Multi Sport Complex, Altvater Cultural Complex and Sebring City Pier might be worth a visit during your stay. Why not add Lakeshore Mall, Sebring Golf Course or Harder Hall Country Club to your agenda too?


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Blindfolded and locked into a box where only her pussy, ass, and feet are free, 21 year old hottie Adriana Chechik gives herself over to the most intense bondage, sex, and orgasms she has ever experienced! Cattle proding, fisting, squirting, rough sex, and humiliation! Don't miss this shoot!
Liz Rainbow is back on Public Disgrace in Barcelona and ready to be completely humiliated in front of huge crowds!Part 1 Fitness DominationThis perky blonde slut needs a workout! And there is no better kink fitness instructor than Mona Wales. Liz Rainbow gets stripped down butt naked in public & jogs a few laps to show off her fat piece of ass in action. Followed by some naked burpees & ass kissing sit ups this slut gets the deep work out. What better fitness then fitting this fat dick in her mouth, Mona finds 2 huge public cocks to stuff down her throat while the audience gets to rip off a whole zipper of clothespins. Ouch! This chubby skank is a cock loving whore! Finally she gets a bath in a public fountain her hot cunt drenched in freezing cold water!Part 2 Double PenetrationLiz Rainbow gets tied up in some tight rope bondage & paraded around a crowded clothing store shocking customers. Everyone gets their hands on this filthy bitch. Customers get to slap her fat ass while she gets stuffed in every hole! Nipple clamps, Corporal Punishment, Caning, Hot Wax it's all open! Finally for her last workout Liz gets fisted & double penetrated while everyone holds her down & then drenched in hot cum!
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Part 1 - The Filthy Fully Naked Street Pet.Alexa Tomas is a perfect, perky, gorgeous, Spanish, goddess that get's put into her filthy slut pet place! Tina Kay is back with another beautiful model for Steve to play with. This time Steve gets a deep throat sloppy blow job at a public beach! He then strips his new pet fully nude and barefoot to walk around the dirty filthy streets of the Barcelona back alleys. He even makes Alexa crawl around on her hands and knees like a dog in heat! Woof Woof!Part 2 - Slutty Pet Begs for a Bone!!Alexa Tomas gets dragged into a crowded pet store and stuffed into a dog kennel along with leash and collar! She is then made to beg for a bone! Steve Holmes is happy to serve her a sausage though! This slutty pet knows how to serve her masters and take all they give her. Deep blowjobs, hard fucking on a pile of dog food, lesbian strap-on and pussy licking, corporal punishment and dog bowl full of cum!
Infamous party girl, Lullu Gun loves tromping around bound and naked. Put on an electronic beat and this little nympho will stun you with her gyrating hips and the bouncing of her little teen titties. Showing her slut hole to everyone in the park makes Lullu a hungry girl. Mona Wales takes her hungry hungry hooker to the nearest Italian spot to fill her mouth hole with carbs and cock. The moment Lullu walks into the restaurant, completely naked and exposed, all the patrons stop what they are doing to stare at her tight little body. Mona explains to everyone at the eatery that Lullu has to sexually service each one of them before Lullu earns the right to eat. Lullu is such an eager whore that she instantly drops to her knees and begins eating pasta off the dicks of strangers. Disgusted by Lullu's hungry cunt, Mona shoves Lullu's face into a full plate of pasta, shoves her onto her back and ruthlessly fists Lullu's gapping gash. Lullu finishes her day with two helpings of jiz directly down her throat.
True submissive and anal whore, Claire Robbins, is pussy clamped, clothes pinned, flogged and fucked all over this haberdasher!! A group of very handsy men take Claire for a ride as she is doubly penetrated with dicks on sticks and touched all over by the nasty greedy grabbies of complete strangers. Claire's dick hungry mouth finds a cock it's never met before and it slides right down her throat. She proceeds to have her cattle prodder virginity taken and is pushed to the MAX by the beautiful and ruthless, Lorelei Lee. You can try this slut on, but you can't take her home! The true owner of her holes is Karlo who fills them up to his every delight.A SHOCKING ANAL POUNDING available at a retailer near you.


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Private room in cabin
Room with sea view in peaceful cottage
Room with sea view in peaceful cottage
4 guests
2 bedrooms
2 beds
2 private baths
4 guests
2 bedrooms
2 beds
2 private baths
Sparkling clean8 recent guests have said that this home was sparkling clean.
Great location94% of recent guests gave this home's location a 5-star rating.
Great check-in experience94% of recent guests gave this home's check-in process a 5-star rating.
Beautiful en-suite room with amazing views in a charming stone cottage 2 Km's off the Wild Atlantic Way between Doolin and Lisdoonvarna. Enjoy the views from your room over the Cliffs of Moher, the Aran Islands and the Burren coastline while relaxing in a peaceful location. Doolin village is only 10 mins away with ferries to the Aran Islands and great pubs with traditional music, food and great pints. ***The price for 4 guests is the same as for 3 guests, please message for more details***
Free parking on premises
Hair dryer
Sleeping arrangements
Bedroom 1
1 queen bed
Bedroom 2
1 double bed
House Rules
Not safe or suitable for children (0-12 years)
No smoking
Not suitable for pets
No parties or events
Check-in time is 5PM - 8PM
Check out by 10AM
33 Reviews
I couldn't imagine a more peaceful and stunningly beautiful spot, or a more gracious host.
Response from John:
Hi Lee. Thank u so much for your kind words. It was just great having you and Zoey stay I enjoyed traveling about with you both, the chats and humor Would love to meet in New York hopefully I will get there late September In the meantime enjoy the rest of your holiday Best regards John
July 2018
Response rate: 100%
Response time: within an hour
Always communicate through AirbnbTo protect your payment, never transfer money or communicate outside of the Airbnb website or app.
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Half of US states issuing IDs that don't meet federal standards
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Опубликовано 14 октября 2016, 22:43
Janitors who clean Target, Best Buy, and Macys in the Minneapolis area have won collective bargaining rights after a 44-month effort. More than 600 janitors in the Twin Cities will now be able to negotiate for better pay, health coverage, and other improvements in the workplace. The campaign for their right to unionize was started by the CTUL nonprofit after they discovered what they call "rampant wage theft" and understaffing. Veronica Mendez, co-director of CTUL, joins RT America's Manila Chan to explain.
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bash, 18 Apr 2017I am using this phone , and everything about it is amazing , battery last for 2 days heavily u... moreThank you very much for this comment. Been searching online forums to learn more about this beast of a phone and how long it's battery lasts. You have helped me to make up my mind now! Once again, thanks so much for your honest opinion.
This is the best phone I've ever owned. Great screen, battery life is amazing, 128GB internal storage great for downloads without worrying about running out of space, all this for 500usd. Bye bye Samsung...
I bought from Hong Kong. It has 20 something language. There's no flaw on this phone. If you dont want to go more expensive stuff, this mobile is way enough.
Firstly, amazing phone.
It records at 1080p not 2160p
It has a 8mp front camera not 5mp
Guys i like everything in this phone but i have never used before. My question is that, what about the camera? Currently i use a mate 8. Is the camera much worse than the mate 8 camera?
Great phone no LTE in the USA, but it's still a great phone. No call issues quality is great.
AnonD-664162, 24 Apr 2017I don't think that this phone has OIS (optical image stabilisation) as stated in your presenta... moreThis phone DOES have image stabilisation contrary to what some people are saying
DefLeppard, 20 May 2017Does anybody know the official SAR value of the Note 8...cant seem to find it anywhere on the net...im not sure about the SAR value, but I know that you can get on for $375 on ebay. http://www.ebay.com/itm/Huawei-Honor-Note-8-Android-6-0-/322468126820?hash=item4b14992064:g:~rsAAOSwTM5Y3SgJ
AnonD-663032, 19 Apr 2017Buy a case on Amazon that is dedicated to the Honor Note 8. It will lock the phone when you cl... moreWhat case
Aadi369, 18 May 2017Is this a water proof phone?No, this beast is not water resistant. I had this phone since November last year and it's awesome!! I love it so much that it was stolen from me when I traveled last month and I ordered another!! I currently have the Huawei mate 9. It's a good phone, but I miss my big screen girl. The phone should be coming soon. I just hope the screen is as perfect as the one that was stolen. Sometimes AMOLED screens are a mixed bag. I always look out for that dreaded discoloration that plagues many of them. But overall, there's nothing not to love about this device. Best bang for your buck! Better than the Sammy S8+ IMO!!
Does anybody know the official SAR value of the Note 8...cant seem to find it anywhere on the net...
I don't think that this phone has OIS (optical image stabilisation) as stated in your presentation. It should have an external sensor attached next to the rear camera, right?
AnonD-663783, 22 Apr 2017Is this the us version!I don't think there is US version, it's getting H+ & 3G on MetroPCS. The model is EDI-AL10.
Trawri, 03 Apr 2017Finally got the phone over 8 weeks waiting it's getting H+ with MetroPCS & like my friend ... moreIs this the us version!
IS there an official measurement of the SAR Value of Huawei Honor Note 8
Trawri, 08 Apr 2017Thank you my friend but I have 2 concerns 1- I'm using a metal case & I think it's weaken... moreBuy a case on Amazon that is dedicated to the Honor Note 8. It will lock the phone when you close the case which is ideal if you just happen to put it down for a few seconds. It won't interfere with the signal strength. Depending where you like (I am in the UK) will depend on the network coverage and the band width. Find a sim card that offers a lot of network coverage. Do your research.
funwithash, 07 Apr 2017Best of luck I am using it it's magnificent peace of technology value for money every thing is... moreI agree with funwithash.
Currently there are top of the range Apple and Samsung products costing around £800. The only difference is the 6GB ram+. The Huawei still punches above its weight with a massive screen and large battery. I did so much research: took me 5 months of differing and still came back to this beast of a phone. It punches above its weight and makes other models feel and look so overpriced. I hope they bring out another version with 8GB Ram and a possible 7" screen. I can watch so many TV neetworks across the globe without having to sign up to broadband. I am saving hundreds per year and my network provides me with 20GB data a month. Why do I need broadband. I can tether my data to my laptop and do exactly the same.
I am using this phone , and everything about it is amazing , battery last for 2 days heavily use with the mobile data on and auto rotate , charges from 10% to 100% within 1 hour 30 minutes. not very heavy compared to its size , amazing resolution , front camera have amazing quality and the rear camera as well . the only negative thing is the video camera stabilizer doesn't work so great . All in All i advice everyone to buy this phone specially if you enjoy using samsung phone


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The second-generation Vigilant Eye System can help achieve this aim. This enhanced product from Fraunhofer FIT uses synchronized fixed surveillance cameras and rapid zoom cameras which provide detailed images to clearly identify culprits.
Vigilant Eye System with one active dome camera: top left the overview image, top right the image from the active camera; bottom right digital zoom image of the section highlighted in the red box, which allows individuals to be identified.
Photo: Fraunhofer FIT
Specialized image analysis algorithms allow the system to automatically detect the use of flares at an early stage and pick out other salient events. The system points out critical situations to surveillance personnel and automatically records high-resolution video footage that can be used in evidence.
Calls are growing for tighter video surveillance in German soccer stadiums. Following the adoption of the German Soccer League's paper on safety in December 2012, Hesse Interior Minister Boris Rhein is now calling for stadium bans to be imposed on those fans caught throwing flares and fireworks following crowd trouble during the second leg match between Leverkusen and Frankfurt.
In an interview with the dpa press agency, he announced that stadium surveillance would be tightened. Many observers, however, doubt whether these measures will actually defuse the situation inside stadiums. Others hope that improved video surveillance technology will identify the actual culprits in the stadium so that blanket punishments imposed on clubs, such as the exclusion of supporters for certain matches or fines, can be avoided. The enhanced Vigilant Eye System from Fraunhofer FIT is a step in this direction. The system has been tested successfully in the AFG Arena in St. Gallen, Switzerland, under real-life conditions.
A basic system uses a fixed surveillance camera, which covers a certain section of the stadium, and either one or two active dome cameras, which can very quickly pinpoint and zoom into scenes in the surveillance area. The Vigilant Eye System synchronizes the cameras with each other. If the operator chooses a certain spot in the overview image using the touchscreen, both cameras immediately lock onto this position. By properly positioning the zoom cameras, situations obscured from the front can also be recorded, such as where flags or crowds of people obscure the view. In other words, where the operator manually adjusts one active camera, the other active camera moves accordingly to provide the best image.
The Vigilant Eye System specifically helps security personnel to investigate suspicious scenes by automatically identifying suspicious situations in the overview image in real time and drawing the operator's attention to these incidents. The system is far more capable than a human observer in this respect, who by their very nature can only scrutinize limited sections of the entire area and may quickly suffer the effects of fatigue.
The system is also specifically programmed to pick out flares and fireworks. All the image data from the active dome camera is recorded in high resolution at 12 frames per second. "The image resolution meets all the requirements for proof of identity and the preservation of video evidence. The achieved zoom levels are currently unrivaled on the market," says Dr. Martina Kolesnik, research scientist at Fraunhofer FIT. The exact position of the individual zoomed images in the overview image is also stored.
When using two dome cameras, the Vigilant Eye System provides the operator with four separate views of the events. The operator sees the image from the fixed surveillance camera in one screen window. Two other windows show the optically zoomed images from the dome cameras. A fourth window can be used to display manually chosen areas of any of the dome camera images using the maximum digital zoom resolution. This enables individuals to be identified and the footage to be used as video evidence. The operator can take specific action to view a scene from various angles using the digital zoom, toggling between the two active cameras in fractions of a second by touchscreen operation of the three windows from the fixed and dome cameras. He can also alter the position and zoom level of the active cameras in this way. Alternatively, the cameras can be controlled using a mouse.
Apart from use in stadiums, the Vigilant Eye System can also be used for security surveillance in buildings, entrance areas, streets, car parks, or restricted areas. It automatically detects security-relevant scenes and stores high-resolution images of these scenes.Contact:
Alex Deeg | Fraunhofer-Institut
Further information:
Further reports about: > Eye Tracking > FIT > German language > Vigilant Eye System > Vigilant windows > high-resolution video footage > soccer > video surveillance
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One of the nicer Holiday Inn Express hotels I've stayed in. The property is clean and well maintained, with room that are well appointed and have comfortable beds. Breakfast was good and the common areas are pleasant with service that keeps everything clean. I recommend this place.More
- Free Wifi
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Julia, your smiles abound
I wanna make it good
I wanna be your love come true
Make it great; see it through
Julia, I love you!
I wanna make you stay in love with me
Julia, I love you
Julia . . .
Golden hair
Eyes of brown
Your touch, so soft
Your kiss astounds
Julia, Julia, Julia . . .
I wanna make you stay in love with me
I'm gonna make you wanna say
Gonna make you wanna stay in love with me, Julia
Julia, Julia, I love you!
Gemini Woman
Gemini Woman
Gemini Woman
I love the way you love me
Your love never brings me down
I love you baby
Smiles abound
Your touch, so soft
Your kiss astounds
Julia, I love you!
Copyright 2014 Kieron McKindle
Kieron McKindle - Music - Julia (acoustic home demo)
- Genre:
- Blues Rock
- Added:
- 07-01-2015
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- Overall perfomance
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Clelia Palace Hotel
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- Title: Clelia Palace Hotel
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text: View - 3 customer review Write a Review "Be the First to Comment" Product Code: 1sk2005-1502 Gleaming Red Georgette Floor Length Anarkali Suit Embroidery Work Availability: In stock $157.00 (72% OFF) $552.00 $157.00 (72% OFF) $552.00 Quantity Add to Wishlist *Tailoring Options Unstitched / Semi Stitched Regular Size Custom Size FREE STITCHING + SHIPPING OFFER FREE SHIPPING on Order respectively!USA - On Order $149+UK - On Order £115+Canada - On Order $198+Australia - On Order $200+Newzealand - On Order $215+Or Equivalent amount in any other Currency. [ NO CODE REQUIRED ] DISPATCH DATEAug 06, 2018 Delivery date: 3-5 business days from the dispatch date Add To CartAdd To Cart Buy Now Add to Wishlist ON TIME DELIVERY 100% ORIGINAL PRODUCTS HASSEL FREE RETURN 24 x 6 SUPPORT Product Description Why Choose Us? Policy Questions? Gleaming Red Georgette Floor Length Anarkali Suit Embroidery Work Designs, patterns and colors may slightly vary from the actual color vs. image due to screen resolution or photography lights. Accessories and other item shown in picture is used for photography will not included in order. Ensure that the first wash of your clothes is always a Dry-Clean. PRODUCT SPECIFICATION Color: No Work: Golden Thread Embroidery , Lace , Patch , Zari Sleeve Style: No Fabric : Georgette Occassion: Party wear , Festival Product Type: salwar kameez * Additional fabric we have to add to make (Plus Size, Top Length, Long & Lining Sleeves). The fabric comes in a matching colour with no embroidery. We assure you for best customer experience at Trendy16. We at Trendy16 are committed to provide you best shopping experience and we make sure we send you best quality and genuine products. 100% Secure Shopping, All Major Cards Accepted. We provide specialized services for getting your garment stitched in sizes 44 and above. The tailors are trained to give required precision and ensure that the garment should look its best in any size you provide us. Shipping Policy Usually we ship all un-stitched outfits in 15 working days, but tentative shipping date is mentioned just below Add To Cart button. Stitched outfits are usually shipped in 18-20 working days. Delivery Policy We deliver our products around the world, although there are a few exceptions. Since the courier companies cannot deliver the products to P.O box address, we request our customers to mention the complete address along with the name of the street and the zip code. To know more, please read our shipment policies. Read more... Return Policy We are always looking forward to give you the best of products at the best of prices and with the best of hopes that we continue our relations till time abides with your love for things Indian! However if due to some unforeseen situation you require the return of the product then the following terms apply for a mutually consented return. Read more... Send Query Have a question about this product? Email us on email@example.com You might also like Hot Pink Georgette Floor Length Anarkali Suit With Embroidery Hand Work $ 287 75% OFF $ 1148 Wishlist Impressive Grey Georgette Long Gown With Hand Work $ 215 75% OFF $ 860 Wishlist Resplendent Pink & Black Georgette Long Anarkali Suit With Embroidery Hand Work $ 227 75% OFF $ 908 Wishlist Pink Mind Blowing NET Gown With Hand Work $ 196 75% OFF $ 784 Wishlist Flaired Cream Georgette Anarkali Gown With Hand Touch $ 278 75% OFF $ 1112 Wishlist Caribbean Green Georgette Floor Length Anarkali Suit Anarkali Suit With Embroidery Hand Work $ 215 75% OFF $ 860 Wishlist Impressive Blue Flower NET Flaired Long Anarkali Suit with Embroidery Work $ 233 75% OFF $ 932 Wishlist Dazzling Multicolor Georgette Big Flair Anarkali Suit with Machine Embroidery Work $ 215 75% OFF $ 860 Wishlist Review this product Quality Nickname Summary Comments Submit


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Duval Deniaud Coffee Table, 2018-01-26 22:29:08. Firstly an wooden ottoman with leather padded surface would give the grandiose feel of a leather table whilst providing fantastic storage space for the user to keep their belongings so as not to clutter up a living space with items that are best kept out of eye view.
Genevieve Palomer Coffee Table, 2018-01-26 22:29:09. Find a coffee table that fits your room size meets your essential needs enhances your color theme and accents your decor. You don't want cups of hot coffee on the floor where a small child could step in them and get burned. People are less likely to spill the coffee if it is on a coffee table to begin with. Coffee tables are referred to as COFFEE ESSENTIALS FOR THE WISE. The right size shape and design coupled with a fashionable set of coasters to coordinate with your coffee table book make all the difference. Add a centerpiece of flowers or your favorite statuary piece to grace the coffee table top and emanate class and style. Enhance your coffee drinking experience with a special table just for coffee.
Burnell Bonnet Coffee Table, 2018-01-26 22:29:09. Thirdly and finally a simple version is the leather upholstered table with a wooden frame with a storage shelf underneath to keep magazines books and other clutter tidy and away from floor areas. This luxurious coffee table model makes a fantastic centrepiece to any living area providing a comfort and usefulness for any family home.
Denisse Coste Coffee Table, 2018-01-26 22:29:10. For families with small children round glass coffee tables are a great choice. While you may have to use Windex a little more often than you would with a wood coffee table there are not sharp corners for your child to inadvertently hit as they are learning to walk. Thanks to the tempered glass they are completely safe even if your child decides that their rattle and your table make really great sounds together.
Genevieve Palomer Coffee Table, 2018-01-26 22:29:11. Wooden coffee tables are also fantastic pieces to have in your home. Often they have more of a rustic look and look good with a neutral or earthy decor. You may have to worry about messing up the stain or paint on a wood table and sometimes they may chip. One major downside to a wooden table is that if you break it you have to purchase a whole new table. With a glass table you could always just get a new piece of glass for the top.
Amelie Faucheux Coffee Table, 2018-01-26 22:29:09. Usually larger or bigger glass coffee table is not advisable in the room since it needs a bigger space to place. The most salable size was small or medium although larger rectangular glass coffee table is good for the offices or to a spacious room. Most of the time people entertain their visitors and friends in the living room where there is a coffee table to hold their drinks.
Burnell Bonnet Coffee Table, 2018-01-26 22:29:10. A clear space for doing arts and crafts - If the table is not going to be used for displaying items it can be left clear for sessions like doing artwork finishing crafts like scrapbooks puzzles or assembling toys like wooden sets cars or robots. The small surface of a coffee table is large enough for both materials and some elbow room but it is comparatively easier to clean and clear away than the floor or the dining table top. For precaution place some protective sheet or paper to prevent permanent streaks on the wood. The height is also ideal for sitting down sans chair in a comfortable position for hours.
Duval Deniaud Coffee Table, 2018-01-26 22:29:10. Many small children have a particular fascination for coffee tables spending hours investigating the treasures that they can hold. It is therefore important to think before placing hot drinks glassware china ornaments nuts or anything else that could be a hazard on the surface. Although all of these factors do require some time and consideration the benefits of keeping your child safe far outweigh any time or financial costs involved. Remember: where children are concerned safety is always the number one priority.
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A significant new building project has recently been completed at one of the National Trust's most popular properties in Hampshire, Mottisfont Abbey. The new development, situated on the banks of the River Test, aims to improve the entrance facilities at this historic priory and country estate - visited annually by over 250,000 people. Designed by Burd...Read more
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Maxtop helps family on BBC DIY SOS Big Build
Worktop specialist Maxtop, has worked with DIY SOS to help renovate the kitchen of a family in need. The programme, which aired at 9pm on BBC One on 1st February, opted for Maxtop Quartz White Jasmine surfaces for the Worcestershire-based, Payne-Cheney family's kitchen. 17 year old Antonia Payne-Cheney was diagnosed with a rare condition called Ehlers-Danlos Syndrome...Read more
Keymer tiles used in relaying of period roof on The Old Vicarage
Keymer's Traditional Elizabethan and Antique roof tiles have been used to restore the roof of the Grade II listed building and period home, The Old Vicarage in Suffolk. The project, which is now completed, was undertaken by house owner Tim Pitt, who was looking to ensure that the roof of the period property was beautifully...Read more
Boost your basement waterproofing knowledge
Boost your basement waterproofing knowledge For specialist basement contractors Triton offers classroom-based training on all types of below ground waterproofing system, as well as on the specification and installation of sumps and drainage, on dampness in buildings and timber preservation, and a new course on ground gas protection. All of these courses can be booked via...Read more
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Unfortunately we are currently out of live mealworms and mini mealworms due to a national shortage. We are expecting this to last for at least another two weeks but as soon as they are in stock we will have them back online here, so keep checking back on the web for any updates. We do have stock of dried mealworms and live waxworms which your birds will both enjoy.
I had an email recently from someone who wanted to know why The Wiggly Bouquets are not organic.
Well there's several reasons;
1. We dont use any pesticides on our cutting patch as a rule, but have never felt the need to actually be certified organic. The principal is in place, and thats it.
2. We use lots of foliage that is harvested from wild overgrown shrubs and hedges that we prune - this would be impossible to certify organic, but to my mind a great, natural way of re-using the best greenery possible.
3. We often buy in extra flowers and to me its much more important to support the local farmer than it is to specify organic - particularly on an item which you are simply not going to eat.
4. Flower Miles; The average bouquet gets flown thousands of miles whether organic or not, better to buy a seasonal bunch produced in the UK, - I reckon.
5. (I know, - I am biased but she did ask...)
Now, there are only so many rafia bows that one woman can tie in a day (!) and so if you would like to order a bouquet for Mothering Sunday (March 18th in the UK) please make sure you click sooner rather than later...


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I want to hire Crooners in Layton, UT
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Complete the form to receive FREE no-obligation quotes from Crooners in Layton.
Cody McKinnon Music(0)
Salt Lake City, UT
23 miles from Layton
Elevate your event with classy live music from the "Modern-Day Crooner." Cody sings jazz, pop, and…
Johnny Al(1)
Salt Lake City, UT
23 miles from Layton
Recent review: I've seen Johnny Al on several occasions...he brings the Great American Songbook to life! Great…
Paul Cave & His Band(19)
Salt Lake City, UT
23 miles from Layton
Recent review: Headline says it all- Paul Cave and his band are absolutely amazing. We hired them for our wedding…
Michael Angiolillo "The Italian Crooner"(25)
Broomfield, CO
Serves Layton
Recent review: I had the Italian crooner come and perform to my now fiancé at a restaurant. She had no idea.…
Steven St. James(4)
Denver, CO
Serves Layton
Recent review: I booked Steven twice for a country club member event with a Martini Bar and 4 course italo-american…
Hot Tomatoes Dance Orchestra(0)
Swing Band / Crooner
Denver, CO
Serves Layton
The Hot Tomatoes Dance Orchestra is one of the most sought-after swing bands in the Rocky Mountain community.…
Dave Halston and the Magic of Sinatra(1)
Frank Sinatra Impersonator / Crooner
Denver, CO
Serves Layton
Recent review: We had Dave Halston and his band at our college casino night event. Working to book Dave was…
Frank Lamphere Rat Pack Style Crooner(0)
Las Vegas, NV
Serves Layton
An exciting, pro Rat Pack "type" jazz vocalist-entertainer with a second-to-none band, for your Las…
Naathan Phan: Magic Asian Man(54)
Comedy Magician / Crooner
Las Vegas, NV
Serves Layton
Recent review: Awesome performance and showmanship ! Our hard to please crowd was wowed and very entertained!…
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Layton UT Crooners
Have you ever thought "they just don't make music like they used to?" You turn on the radio now and hear the screams of rock stars, the booming bass lines of hip hop music, or that wretched thing called "auto-tune." What happened to old fashioned wholesome music? Just a sharp dressed guy in front of a microphone singing...or a better term - crooning. Lucky for you, the genre isn't completely lost. These crooners are keeping that old sound and style alive, paying tribute to the original crooners, singing all the pop standards of the 20s through 50s. Search for Crooners in Layton, Utah above.
Please note that these Crooners may also travel to South Weber, Fruit Heights, Hill Afb, Syracuse, South Ogden, Sunset, Murdock, Farmington, Clinton, Mountain Green, West Point, West Haven, Hooper, Morgan, Centerville, Woods Cross, Harrisville, Farr West, Huntsville, North Ogden, Pleasant View, North Salt Lake, Plain City, and Eden.


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Looking for a vacation rental in Darling Harbour? Tripping.com has 12316 vacation rental homes available in Darling Harbour. You'll find 34 studios, 6024 1-bedroom, 2616 2-bedroom and 3642 rentals with 3 or more bedrooms ranging from $25 a night. For extra convenience, many of these vacation homes can be booked directly online.
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Today's Featured Artist: Michael Godard
Transform your photos into one-of-a-kind, hand painted masterpieces!
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by Mike Nellums
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Our ceramic coffee mugs are available in two sizes: 11 oz. and 15 oz. Each mug is dishwasher and microwave safe.
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Thank you, Melissa, for favoriting my "Keukenhof Gardens 74" photograph. Mike Nellums
Fantastic image! Featured in The Best of Fine Art America Group!
Mike Nellums replied:
A rainbow of pure natural beauty, Mike! WOW! It is a true honor to bestow upon you the special recognition, of being Featured on our homepage, due to the professional quality, creativity, and pure beauty of this fine piece of art work. As administrator of the Wisconsin Flowers and Scenery group, I am proud of you for this accomplishment. I Liked and Faved. R.B. Rosenberger (admin. of the WFS group)
Mike Nellums replied:
Thank you so much, Randy, for the honor and the prestige of being a part of such a wonderful and talented group as the Wisconsin Flowers and Scenery group. Mike Nellums
Average Rating (5 Stars):
Kathryn Hirst
July 16th, 2018
Here is another breath-taking photograph taken recently at the world-famous Keukenhof Tulip Gardens near Amsterdam, The Netherlands.
"A MOMENT CAPTURED IN TIME... TIME CAPTURED IN A MOMENT". Welcome to my world, and to the way I see things. You're invited in to wander among the many images that live here. If you see something you've never seen... If you experience something you've never felt before... Or If I can make you smile... Or if I can take you to a place you've never been before, Then my work within these galleries exists for a reason. Sure, everything here is FOR SALE. But any joy you might come away with - is Free. On the house. So, thank you for being here. Stay as long as you like. And I do hope you stop in again. COPYRIGHT NOTICE All photographs on this web site are fully protected by U.S. and international copyright laws, all rights...
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Fine Art America sells thousands of pieces of artwork each month - all with a 100% money-back guarantee. We take great pride in the fact that hundreds of thousands of artists have chosen Fine Art America to fulfill their orders, and we look forward to helping you select your next piece!
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The existence of traders and sourcing agents is due to the fact there are numerous manufacturers who vary in the capability of export, understanding of the international market, domestic business performances and foreign language skills, etc. The international market needs a role to bridge the space between international buyers and manufacturers. However, while there are numerous buyers (consciously or unconsciously) coping with trading companies, some buyers in particular those with specific technical requirement would rather hire China Purchasing Agent. Why do they shift from traders to a sourcing agent or sometimes not even directly cope with a manufacturer?
With a good sourcing agent, the buyer's interests are fully enacted in a very controlled manner. Firstly, with someone getting deep in to the factories, the customer has a better control of the production, delivery and after-sale service, and then he could make sure each of the followup information he receives is valid and proved. Secondly and even more importantly, the sourcing agent can jointly or independently discover suppliers information and negotiate using the suppliers with no motivation to win your order or sell a particular product. Therefore, the purchaser is more likely so that you can locate a more desirable product because he fails to get confused through the exaggerated or perhaps untrue descriptions from your trader or manufacturer.
Lacking professionalism in sourcing agents is a huge concern for many global buyers, it has been a so controversial issue that people have heated debate over the advantages and disadvantages of getting a sourcing agent. Numerous buying offices and sourcing agents themselves have a tendency to accuse the conduct of taking kickbacks, and after accomplishing this they shift the buyers' attention to their own services and advertise that they may never make use of this unethical behavior. However, it needs to be admitted that all are in essence agents, and they are generally all likely to belong to this lapse, but few of them shed much light on methods to this matter. The issue is just due to human nature. For example, a number of them may have mixed feelings when they offer the quotations for their clients, they may ask themselves, "I came across so amazing a supplier for my client, and they also get so good price, shouldn't I deserve some thing?" "The packaging and shipping cost me a great deal, and it also took us a quite a bit of effort in talking to this supplier, do you benefit my clients only to make ends meet?"
A standard practice is the fact that some suppliers willingly give sourcing consultants or translators an accumulation hidden commission to be able to win an order or even the latter asks for kickbacks through the suppliers, however, this practice is not only unethical and unprofessional, but also practically unsustainable, because although unlikely some day the suppliers could tell the truth to the buyer, the sourcing agent would find himself only a tool for your suppliers and, a whole lot worse, turn out to be no long trusted through the client.
A sourcing agent can provide the purchaser with full info on registration details, official documents, latest photos and written reports about the factory including offices, production lines, warehouses, quality control station, lab equipment, etc to access the factory's qualifications, credibility, production capacity and technical expertise. But traders nmnwti send any data towards the buyer as well as claim they are manufacturers of any product, while the reality is they may not be technically sound or have enough production capacity.
An excellent sourcing agent is actually a person with sound English fluency and understanding, general technical knowledge, business assessment, logistics, product design and global perspective. He could work perfectly on behalf of the purchaser to gain access to suppliers, negotiate the purchase price and terms, do trouble-shooting, order follow-up, coordinate in urgent times, and lastly, enhance the business relationship with the supplier.
To begin with, sourcing agents or representatives usually work in a smaller team or just work alone, while trading companies work in bigger offices with multiple departments. The effect is the expenditures burdened through the latter are much heavier. However, a bigger reason is definitely the conflict of interests involving the trader and also the buyer, the trader will never share the manufacturer's information (contact, original price) with the buyers for fear the buyer could skip the trader and deal directly with all the original supplier, in every case, the trader strikes an arrangement with all the buyers with a hidden and highest margin, whilst the China Sourcing Agent works for the purchaser in a clear-set service fees. In conjunction with the cost factor, the cost the purchaser could get from the trader is much greater than the fees he must pay a sourcing agent.


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lemon pudding cake using yellow mix signature supreme recipes.
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