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(ve doe LIZ ue mab)
Dosage Forms
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution Reconstituted, Intravenous [preservative free]:
Entyvio: 300 mg (1 ea) [contains mouse (murine) and/or hamster protein, polysorbate 80]
Brand Names: U.S.
- Entyvio
Pharmacologic Category
- Gastrointestinal Agent, Miscellaneous
- Monoclonal Antibody
- Monoclonal Antibody, Selective Adhesion-Molecule Inhibitor
Vedolizumab is a humanized monoclonal antibody that binds to the alpha4beta7 integrin and blocks the interaction of alpha4beta7 integrin with mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and inhibits the migration of memory T-lymphocytes across the endothelium into inflamed gastrointestinal parenchymal tissue. The interaction of the alpha4beta7 integrin with MAdCAM-1 has been implicated as an important contributor to the chronic inflammation that is a hallmark of ulcerative colitis and Crohn disease.
Vd: 5 L
Half-Life Elimination
25 days (serum, at 300 mg dosage)
Use: Labeled Indications
Crohn disease: Treatment of moderately to severely active Crohn disease in patients who have had an inadequate response with, lost response to, or were intolerant to inhibitors of tumor necrosis factor-alpha (TNF-alpha) blocker or immunomodulator; or had an inadequate response with, were intolerant to, or demonstrated dependence on corticosteroids.
Ulcerative colitis Treatment of moderately to severely active ulcerative colitis in patients who have had an inadequate response with, were intolerant to inhibitors of tumor necrosis factor-alpha (TNF-alpha) blocker or immunomodulator; or had an inadequate response with, were intolerant to, or demonstrated dependence on corticosteroids.
Serious or severe hypersensitivity to vedolizumab or any component of the formulation
Canadian labeling: Additional contraindications (not in US labeling): Patients with active severe infections or opportunistic infections.
Dosing: Adult
Note: Prior to initiating treatment, all patients should be brought up to date with all immunizations according to current immunization guidelines.
Crohn disease or ulcerative colitis: IV: 300 mg at 0, 2, and 6 weeks and then every 8 weeks thereafter. Discontinue therapy in patients who show no evidence of therapeutic benefit by week 14.
Dosing: Geriatric
Refer to adult dosing.
Dosing: Renal Impairment
There are no dosage adjustments provided in the manufacturer's labeling (has not been studied).
Dosing: Hepatic Impairment
There are no dosage adjustments provided in the manufacturer's labeling (has not been studied). Discontinue use with jaundice or signs/symptoms of hepatic injury.
Reconstitute at room temperature with 4.8 mL of sterile water for injection. Gently swirl vial for at least 15 seconds; do not vigorously shake or invert. Allow the solution to sit for up to 20 minutes at room temperature to allow for reconstitution and for any foam to settle; the vial can be swirled and inspected for dissolution during this time. If not fully dissolved after 20 minutes, allow another 10 minutes for dissolution. Do not use the vial if the drug product is not dissolved within 30 minutes. Solution should be clear or opalescent, colorless to light brownish yellow and free of visible particulates. Do not administer reconstituted solution showing uncharacteristic color or containing particulates.
Prior to withdrawing the reconstituted vedolizumab solution from the vial for dilution, gently invert vial 3 times. Add the 5 mL (300 mg) of reconstituted vedolizumab solution to 250 mL of sterile sodium chloride 0.9% and gently mix the infusion bag. Once reconstituted and diluted, use the infusion solution as soon as possible.
IV: Infuse over 30 minutes. Do not administer by IV push or bolus. Following infusion , flush with 30 mL of sterile 0.9% sodium chloride injection. Observe patients during infusion (until complete) and monitor for hypersensitivity reactions; discontinue if a reaction occurs.
Refrigerate unopened vials at 2°C to 8°C (36ºF to 46ºF). Retain in original package to protect from light. Following reconstitution and dilution, the infusion solution may be stored for up to 4 hours at 2°C to 8°C (36ºF to 46ºF). Do not freeze. Discard any unused portion.
Drug Interactions
Anti-TNF Agents: May enhance the adverse/toxic effect of Vedolizumab. Avoid combination
BCG (Intravesical): Immunosuppressants may diminish the therapeutic effect of BCG (Intravesical). Avoid combination
Belimumab: Monoclonal Antibodies may enhance the adverse/toxic effect of Belimumab. Avoid combination
Coccidioides immitis Skin Test: Immunosuppressants may diminish the diagnostic effect of Coccidioides immitis Skin Test. Monitor therapy
Denosumab: May enhance the adverse/toxic effect of Immunosuppressants. Specifically, the risk for serious infections may be increased. Monitor therapy
Echinacea: May diminish the therapeutic effect of Immunosuppressants. Consider therapy modification
Fingolimod: Immunosuppressants may enhance the immunosuppressive effect of Fingolimod. Management: Avoid the concomitant use of fingolimod and other immunosuppressants when possible. If combined, monitor patients closely for additive immunosuppressant effects (eg, infections). Consider therapy modification
Leflunomide: Immunosuppressants may enhance the adverse/toxic effect of Leflunomide. Specifically, the risk for hematologic toxicity such as pancytopenia, agranulocytosis, and/or thrombocytopenia may be increased. Management: Consider not using a leflunomide loading dose in patients receiving other immunosuppressants. Patients receiving both leflunomide and another immunosuppressant should be monitored for bone marrow suppression at least monthly. Consider therapy modification
Natalizumab: Vedolizumab may enhance the adverse/toxic effect of Natalizumab. Avoid combination
Nivolumab: Immunosuppressants may diminish the therapeutic effect of Nivolumab. Consider therapy modification
Ocrelizumab: May enhance the immunosuppressive effect of Immunosuppressants. Monitor therapy
Pidotimod: Immunosuppressants may diminish the therapeutic effect of Pidotimod. Monitor therapy
Pimecrolimus: May enhance the adverse/toxic effect of Immunosuppressants. Avoid combination
Roflumilast: May enhance the immunosuppressive effect of Immunosuppressants. Consider therapy modification
Sipuleucel-T: Immunosuppressants may diminish the therapeutic effect of Sipuleucel-T. Monitor therapy
Tacrolimus (Topical): May enhance the adverse/toxic effect of Immunosuppressants. Avoid combination
Tertomotide: Immunosuppressants may diminish the therapeutic effect of Tertomotide. Monitor therapy
Tofacitinib: Immunosuppressants may enhance the immunosuppressive effect of Tofacitinib. Management: Concurrent use with antirheumatic doses of methotrexate or nonbiologic disease modifying antirheumatic drugs (DMARDs) is permitted, and this warning seems particularly focused on more potent immunosuppressants. Consider therapy modification
Trastuzumab: May enhance the neutropenic effect of Immunosuppressants. Monitor therapy
Travelers' Diarrhea and Cholera Vaccine: Vedolizumab may diminish the therapeutic effect of Travelers' Diarrhea and Cholera Vaccine. Management: Administer travelers' diarrhea andl cholera vaccine prior to initiation of therapy with vedolizumab. Consider therapy modification
Vaccines (Inactivated): Immunosuppressants may diminish the therapeutic effect of Vaccines (Inactivated). Management: Vaccine efficacy may be reduced. Complete all age-appropriate vaccinations at least 2 weeks prior to starting an immunosuppressant. If vaccinated during immunosuppressant therapy, revaccinate at least 3 months after immunosuppressant discontinuation. Consider therapy modification
Vaccines (Live): Immunosuppressants may enhance the adverse/toxic effect of Vaccines (Live). Immunosuppressants may diminish the therapeutic effect of Vaccines (Live). Management: Avoid use of live organism vaccines with immunosuppressants; live-attenuated vaccines should not be given for at least 3 months after immunosuppressants. Avoid combination
Adverse Reactions
Central nervous system: Headache (12%)
Immunologic: Antibody development (4% to 13%; neutralizing: 2%)
Neuromuscular & skeletal: Arthralgia (12%)
Respiratory: Nasopharyngitis (13%)
1% to 10%:
Central nervous system: Fatigue (6%)
Dermatologic: Pruritus (3%), skin rash (3%)
Gastrointestinal: Nausea (9%)
Hepatic: Increased serum ALT (≥3 x ULN: <2%), increased serum AST (≥3 x ULN: <2%)
Infection: Influenza (4%)
Neuromuscular & skeletal: Back pain (4%), limb pain (3%)
Respiratory: Upper respiratory tract infection (7%), cough (5%), bronchitis (4%), oropharyngeal pain (3%), sinusitis (3%)
Miscellaneous: Fever (9%), infusion related reaction (4%)
<1% (Limited to important or life-threatening): Hepatitis, hypersensitivity reaction, infection (including anal abscess, sepsis, tuberculosis, salmonella sepsis, listeria meningitis, giardiasis, cytomegaloviral colitis), malignant neoplasm (excluding dysplasia and basal cell carcinoma)
Concerns related to adverse effects:
• Hypersensitivity reactions: Hypersensitivity reactions have been reported including anaphylaxis. Allergic reactions including dyspnea, bronchospasm, urticaria, flushing, rash, and increased blood pressure and heart rate have also been observed. Symptom onset may vary from during the infusion, immediately post-infusion, to several hours post-infusion. If serious reactions occur, discontinue administration immediately.
• Infections: Use may be associated with an increased risk for developing infections; most commonly reported infections included upper respiratory and nasal mucosa. Serious infections have also been reported in patients treated, including anal abscess, sepsis (some fatal), tuberculosis, salmonella sepsis, Listeria meningitis, giardiasis, and cytomegaloviral colitis. Therapy is not recommended in patients with uncontrolled, active, severe infections. If a patient develops a serious infection, consider discontinuing therapy. Use with caution in patients with a history of recurring severe infections. Screening for tuberculosis should be considered.
• Liver injury: Elevations of transaminase and/or bilirubin have been reported in patients receiving vedolizumab. Discontinue therapy in patients with jaundice or other evidence of significant liver injury such as fatigue, anorexia, right upper abdominal discomfort, or dark urine.
• Progressive multifocal leukoencephalopathy: Integrin receptor antagonists have been associated with progressive multifocal leukoencephalopathy (PML), a rare and often fatal opportunistic infection of the central nervous system caused by the John Cunningham (JC) virus. Monitor patients for any new onset or worsening of neurological signs and symptoms including progressive weakness on one side of the body or clumsiness of limbs, disturbance of vision, and changes in thinking, memory, and orientation leading to confusion and personality changes. Symptoms may progress over days to weeks and can lead to death or severe disability in weeks to months. If PML is suspected withhold therapy and refer to a neurologist; if confirmed, discontinue therapy permanently.
Other warnings/precautions:
• Immunizations: Patients should be brought up to date with all immunizations according to immunization guidelines before initiating therapy. Live vaccines should not be given concurrently unless the benefits outweigh the risks; there are no data on the secondary transmission of infection by live vaccines with vedolizumab. Non-live vaccines may be given concurrently.
Monitoring Parameters
Observe patients during infusion (until complete) and monitor for hypersensitivity reactions; LFTs; tuberculosis screening according to local practice; signs/symptoms of infection; any new onset or worsening of neurological signs and symptoms
Pregnancy Risk Factor
Pregnancy Considerations
Adverse events have not been observed in animal reproduction studies. Monoclonal antibodies are transported across the placenta in a linear fashion as pregnancy progresses, with the largest amount transferred during the third trimester. Any adverse pregnancy effect would likely be greater during the second and third trimesters of pregnancy.
Health care providers are encouraged to enroll women exposed to vedolizumab during pregnancy in a pregnancy exposure registry. Information about the registry can be obtained by calling 1-877-825-3327.
Patient Education
• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
• Patient may experience back pain, common cold symptoms, joint pain, nausea, rhinitis, pharyngitis, extremity pain, or loss of strength and energy. Have patient report immediately to prescriber signs of infection, signs of infusion reaction, signs of liver problems (dark urine, feeling tired, lack of appetite, nausea, abdominal pain, light-colored stools, vomiting, or yellow skin or eyes), shortness of breath, wheezing, coughing, dizziness, flushing, tachycardia, arrhythmia, severe headache, or signs of progressive multifocal leukoencephalopathy (confusion, depression, trouble with memory, behavioral changes, change in strength on one side, trouble speaking, change in balance, or vision changes) (HCAHPS).
• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.
Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.
More about vedolizumab
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- En Español
- 21 Reviews – Add your own review/rating
- Drug class: selective immunosuppressants
Consumer resources
Professional resources
Other brands: Entyvio


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It's mid-winter of 1893 when he first sees her in Rock Creek Park, that huge green swath of paths, gardens, parkland, and wilderness that runs like a backbone through the center of the city. This particular Saturday afternoon, enjoying the unseasonably mild February weather that has coaxed early narcissus to poke up through the leaf litter, he finds himself near the stables. Here are some other folks taking in the lovely day. A party of five or six people appears to be readying for a trail ride: men in boots and jodhpurs, women in long black skirts and riding hats. Charley folds his arms on the top of the rail fence to watch as the men joke among themselves and the women fuss about in preparation for mounting.
Then he notices one other woman, who holds herself separate from the others. While the rest of the party has clearly left the dirty work of preparation to the stable hands, this woman is doing her own final checks of the saddle, bridle, and stirrups. He smiles to himself when he sees that she knows the trick the horses like to play on an unsuspecting rider, of taking in air as he buckles the saddle strap, then exhaling after the rider mounts to loosen the saddle. Charley has seen novices slide completely underneath their horses after falling for that trick. This woman knows to wait until the very end of her preparation, after the horse has relaxed, to do a final quick cinch on the strap, catching the horse unawares.
It is not until the larger party is finally mounted and sauntering out of the fenced barn area that he's sure she isn't with them. Though she has done her own tack work, he senses that she is somehow of a higher social status and breeding than the rest of the riders, as though she has been raised to know the intrinsic value of doing some things for herself, a trait he sometimes observes in people who come from old money. She carries herself with a self-assuredness that gives her movements both grace and focus, but with a firm and unsmiling expression that makes her fully unapproachable. Finally, in one smooth motion, she fixes her foot in the stirrup and swings herself up unassisted, and arranges her sidesaddle position. Without any noticeable signal on her part, the horse takes two or three steps and then breaks into a slow trot out of the yard. He watches as the horse and rider gain speed across the grassy field, break into a full gallop, and disappear into the woods.A slightly built, sinewy man with a permanent walrus mustache, he is both quick and surprisingly strong, his grip impressive even in an affable handshake. Charley is everyone's friend and nobody's enemy, and he is a wizard when it comes to building and fixing things. There is nothing he can't make out of concrete, and the house and yard at 741 is the proof of it: ponds, fountains, retaining walls, the foundations for the pump house and barn, the floor for the garages he rents out to the apartment dwellers across the road who have no other place to park their cars. At home, if Charley Beck isn't reading the newspaper, he is working in the garden; if he's not in the garden, he's building something new or fixing something that's broken. If he is doing none of these things, he is rubbing under his battered fedora at the hole in the back of his neck, considering what to do next. A born farmer, a natural mechanic, and a modern-day homesteader, Charley Beck is a self-taught Renaissance man. Wednesday, May 6th, 1896: I had baby's pictures taken; she is just nine months and eight days old. Such a time as we had; she was just as good as could be. She is always good, especially when she is out. The artist tried to keep her perfectly still, but that was impossible for baby. She would put her little finger in her mouth, and draw her little face up so funny, as she always does when she sees strangers, and we could not get her to smile. She would not smile no matter what we did, so we had to take her with her serious little face. After she had her picture taken, we took her down to the office. The folks took her around everywhere and thought she was just as cute and as sweet as could be. She was very good and never cried once. Sunday Dec 13th, 1896: A friend came out to take baby's picture, and Oh! such a time as we had trying to keep baby quiet for just a second. She would not keep still, so I guess we did not get a good one of her. We wanted to have the cats picture taken, but Tom was nowhere to be found, but just as Mr. Heilman was getting ready, here comes Tom up the road. We hustled him up on the porch by the side of the baby, then baby began hugging Tom, well that would not do, so we gave baby a graham cracker to eat to keep her quiet. When Tom saw the cracker he wanted it so we gave him a piece, then baby would stoop down and get the cats cracker and so between the baby and the cat we had a perfect show. The cat would sit still a minute, then the baby would move, when the baby was still the cat would move, we laughed and laughed, and it was about an hour before we had the picture taken. The weather has been beautiful. Just think of baby standing on the porch, with a while mull dress on, with short sleeves in the middle of December.

subset: commoncrawl


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Parkland Wood Blinds
Parkland® Wood Blinds
- 100% basswood
- Wide selection of Paints and Stains
- Hide Cord Holes with de-Light™
We feature an exotic range of wood blinds made from the finest North American hardwoods – including genuine oak, ash, knotty pine, cherry and Brazilian cherry. These wood blinds offer unique furniture-quality stains and specialty finishes. Distressed and glazed finishes also provide warm, rich, antique styling. With many different style options available, choose flat for a more contemporary look, or generously-sized, beveled slats with decorative tapes to exude tradition and character.


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How Bien Cuit Assembled a Roster of Fine-Dining Pastry All-Stars
Cooks have left jobs at the NoMad, Locanda Verde, and Daniel to work at the bakery.By Sierra Tishgart
Cooks have left jobs at the NoMad, Locanda Verde, and Daniel to work at the bakery.By Sierra Tishgart
Lattes, cocktails, pastries, and more.By Sierra Tishgart
Butchers, bakers, pickle-makers, and spice merchants.By Robin Raisfeld, Rob Patronite, Mary Jane Weedman and Hugh Merwin
It¹s no longer enough to simply shove a scoop of artisanal ice cream between two cookies and call it a day.By Rob Patronite and Robin Raisfeld
Plus, Jell-O shots at the Meatball Shop, beer made with coffee, an homage to Fifty Cent, and more in today's leftovers.
This is a once-in-a-lifetime holiday.By Sierra Tishgart
New York is experiencing something of a rye revival.By Robin Raisfeld and Rob Patronite
The bread is still baking in Brooklyn, however.By Hugh Merwin
The Smith Street bakery's Christopher Street location remains closed.By Hugh Merwin
Our town's artisanal bakers have been busy giving the pastry a gourmet upgrade, and the time for a full-fledged renaissance has arrived.By Robin Raisfeld and Rob Patronite
The bakery is launching a regular weekend pop-up marketplace for its loaves.By Devra Ferst
It's not just for dessert anymore.By Robin Raisfeld and Rob Patronite
"My neighbors and I drank Champagne and annihilated the piñata, and then rushed off to Mission Chinese for dinner."By Alan Sytsma
Plus: sandwiches at Bien Cuit, quinoa chocolate bars at Hu Kitchen, and more in our weekly roundup of healthy eats.By Kate Lowenstein
Also, she fights her way through a nasty cold with anchovies on toast and a lot of gelato.By Hugh Merwin
Plus: Ben and Jack's Steakhouse will reopen in a brand-new space, and more in today's leftovers.
New Yorkers cleaned up.By Sierra Tishgart
Plus, Bien Cuit expands, Toby's Estate Coffee annexes a bit of Union Square, and more in today's leftovers.
"And how did the ground zero of the Brooklyn food explosion land in my neighborhood? I swear, if I can't walk or bike to it, I pretty much don't go."By Alan Sytsma
Plus, Ryan Sutton and Robert Sietsema on La Mar Cebicheria, Lauren Shockey on Redfarm, and more of this week's reviews.By Bianca Male
Black Women Kept Roy Moore Out of Office. Here's How to Actually Thank Them.
9 Notorious Prince Philip Stories
Omarosa Reportedly Had to Be Physically Removed From the White House
Morgan Spurlock Calls Himself 'Part of the Problem' in Letter About Sexual Misconduct
Harvey Weinstein Blackmailed Salma Hayek to Get That Gratuitous Nude Scene in Frida
Mr. Robot Season-Finale Recap: Learning to Live
What Crazy Ex-Girlfriend's Depiction of Mental Illness Has Meant to Me This Season
All 218 U2 Songs, Ranked From Worst to Best
Every Star Wars Movie, Ranked
The GOP Is About to Tumble Into Full-scale Panic


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The Smart vision EQ fortwo is Daimler AG's take on the future of mobility. This electric concept has no pedals or steering wheel and considers a future with autonomous car sharing.
Concept Cars
Design a car | The List #0030
On this episode of The List, Patrick and Jessi learn the entire vehicle design process from start to finish and try their hand at designing their very own car at the Art Center College of Design.
10 things you should know about Volvo's new compact cars
More details on Volvo's new 40-series small cars, including powertrain specs, body styles, and electrification.
VW Q3 Financial Woes, 2015 Tokyo Motor Show | Autoblog Minute
Consumer Reports pulls its Tesla recommendation, the U.S. Copyright Office offers a ruling affecting car owners, VW gets hit hard with third quarter losses, and lots of exciting news from Tokyo. Autoblog's Senior editor Greg Migliore reports on this Autoblog Minute Weekly Recap.
Toyota U-squared urban utility concept inspired by Maker Faire [w/video]
There's a quiet revolution happening in US cities. People want to mix an urban lifestyle with a connection to nature and appreciation for craftsmanship. The result of all of this is folks pursuing things as varied as urban farming, home brewing and the whole maker movement. Toyota thinks it has the perfect concept for these intrepid customers with its new Urban Utility – or, U-squared, not U2 like the band – concept that it is debuting during a panel discussion hosted by Make: magazi
Chrysler readying 20 Moparized vehicles for SEMA
The Las Vegas Convention Center has plenty of space for aftermarket companies and automakers to show off their wares, and it looks like Chrysler is taking advantage of the spacious floor plan. At next month's SEMA Show, Chrysler will have a full 20 cars from its six brands decked out with Mopar gear.
Jaguar C-X17 crossover concept revealed, hides new lightweight aluminum architecture [w/video]
Just as Jaguar teased earlier this month, the luxury marque is debuting its first-ever sports crossover concept at the 2013 Frankfurt Motor Show, which begins this week. In addition to previewing what a soft-roading Jag might look like, the C-X17 concept also showcases the brand's new advanced unibody aluminum architecture, which it calls the future of its brand.
Are you the soon-to-be-revealed Jaguar CUV concept?
Following the teaser of the Jaguar CX-17 Concept released last weekend, the first official image of the Jaguar crossover concept appears to have hit the Internet ahead of its introduction at the Frankfurt Motor Show.
Jaguar C-X17 Concept teased before Frankfurt
Just ahead of the Frankfurt Motor Show, which begins September 10, Jaguar is teasing the reveal of a design study to introduce its new advanced vehicle architecture. Dubbed the C-X17, the mysterious concept "illustrates the diversity of vehicles that could be produced using this architecture, which underpins the innovative future of the Jaguar brand."
Gran Turismo 6 to get exclusive concept cars from Aston, BMW, Nike and more
Much like a real conflict, the console wars being waged between Microsoft and Sony spill into a number of different battlefields and theaters. Home to some of the fiercest fighting is the racing genre, which sees Microsoft's Forza Motorsport series go head-to-head with Sony's Gran Turismo series. While there's been plenty of press about Forza, GT has just struck back with some news that we aren't sure Turn 10 Studios and Microsoft can match.
Mitsubishi CA-MiEV and GR-HEV concepts peek out before debut
We're getting a look at the two star Mitsubishi concept cars from this year's Geneva soiree, just ahead of the official debut for both. As suits Mitsubishi's ever-deepening interest in electrified vehicles, the brace of concepts both make use of electric drive: the CA-MiEV being a pure electric vehicle and the GR-HEV using a diesel-electric powertrain.
Toyota debuts Furia concept, heralds next Corolla design
After playing it safe over the last several generations of the Toyota Corolla, it appears Toyota might finally be ready to make a big leap forward. Toyota has finally unveiled the 2013 Corolla Furia Concept at the Detroit Auto Show, which hints at the future design for this automaker's popular compact (the Corolla is actually the best-selling car of all time).
Hyundai goes bonkers with performance Velosters
Hyundai's news that it would be producing a new Re:Mix edition of the Veloster was passingly interesting, at least for fans of the sprightly hatchback. But that wasn't the only Veloster we saw at the SEMA show this year... far from it.
Ford shows SEMA-bound Mustang, F-150 and Escape variants
After already tipping its hand with a goodly selection of Focus ST concept teasers, as well as a passel of tuned Fusions, Ford has let loose with more images and information regarding its huge presence at this year's SEMA show. And, while we'll be bringing live reports of all the SEMA goodness to you next week, we couldn't help but want to share these last minute previews.
VW shows Taigun small CUV at São Paulo motor show
We didn't have to wait very long for recent reports of a new small Volkswagen crossover to come true... well, sort of. In a side note to our report on a seven-passenger VW CUV last week, we also mentioned the possibility of a new sub-Tiguan crossover, and we may have gotten our first look at such a vehicle courtesy of this Volkswagen Taigun Concept that is debuting at the São Paulo motor show.
Geneva-bound Seat Toledo showcar is a concept in name only
The Seat Toledo Concept that we'll see at the Geneva Motor Show is the precursor for the Seat Toledo that will go on sale later this year in Spain – hence its description as a "close-to-production study." The "study" part is how Seat has integrated its IBE, IBX and IBL concepts into a production sedan, and how it plans to make that car "exceptionally good value for money."
Hyundai i-oniq concept for Geneva opens up ahead of schedule
Just as nature abhors a vacuum, the Internet abhors secrets. Hyundai got so close to keeping its i-oniq concept coupe away from us before the Geneva Motor Show, but the web won again when someone uploaded images of ithe i-oniq's blood red interior and McLaren MP4-12C-like doors.
Hyundai i-oniq concept for Geneva opens up ahead of schedule
Just as nature abhors a vacuum, the Internet abhors secrets. Hyundai got so close to keeping its i-oniq concept coupe away from us before the Geneva Motor Show, but the web won again when someone uploaded images of ithe i-oniq's blood red interior and McLaren MP4-12C-like doors.
Translogic gets inside look at Rinspeed's concept shop
Another week brings another action-packed episode of Translogic. Our sister site continues its tour of Europe with a trip to Switzerland's Rinspeed. If there's a car builder that more resembles a toy company for adults, we can't imagine it.


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We're proud to announce that we'll be getting a SECOND portable aerial rigging system AND a double point Lyra! With a second set of rigging equipment we can now host bigger Aerials classes and have multiple students training on different aerial equipment at the same time!
But wait, that's not all! You asked for it, you're getting it… Are your ready for POLE FITNESS?! We're getting not one, but TWO Poles for the school!!!
We're committed to become your one stop shop for training in movement arts in area, and we're growing because you! Thank you for support, and for helping us bring this vision to life! Get in, get fit, get training, train like a ninja!
Your friendly neighborhood Ninja,
Shinobi Poli


text: We stayed here for the Victorian Extravaganza weekend in May, the hotel itself is old world, nicely decorated in a traditional style. We had the standard family room which is had a queen size bed and a single bed plus they brought in a futon bed (nice wood base with thick futon mattress) for our other son. Clean and comfortable... More


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See the image below and note the role of ACAT (Acyl Co A cholesterol acyl transferase) in the esterification of cholesterol. Cholesterol is stored in the cell in the form of cholesteryl esters. Esterification involves the coupling of cholesterol with a fatty acid, generally this fatty acid is a-
A. Saturated fatty acid
B. Monounsaturated fatty acid
C. Polyunsaturated fatty acid
D. Dienoic acid
E. Any of the above.
Figure- LDL uptake and fate of cholesterol.
Check the details in
2 Responses to Esterification of cholesterol by ACAT
Nice & easy to understand.


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The World Is Starving
MMI has partnered with PureGrown Aquaculture who has a State-of-the- Art Aquaculture Facility on 40-acres located in western Martin County between Stuart and Okeechobee. Offering safe, fully traceable, sustainably grown, pathogen and chemical free aquaculture products.
This partnership gives us the ability to provide a healthy protein diet and we share our technology around the world so every child can have protein diet meals.


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If you want to update your garden but you haven't got a lot of time, there are plenty of things you can do to make it look better. Check out these easy ways to update your garden in no time:
Get Some New Ornaments
If you don't have ornaments in your garden, you're missing out on a great opportunity to accessorise it. If you do, could you replace them or tidy them up in any way? Get some nice new ornaments and you'll instantly update the look of your garden.
Replace Your Slabs
If your paving slabs are cracked or really dirty, it can be difficult to make them look presentable again. You should probably replace them if you can so that they have that brand new look again. Go for a different kind of slab to the one you had before to get a completely new look in your garden.
Tidy it Up
Simply tidying up your garden could be a wonderful way to update your garden. It really can make a big difference when you get rid of dead plants, get rid of weeds, and rearrange. Make it practical for you and your guests, and try to look at it as if it wasn't your garden.
Get New Seating
Is your seating old, leaving a lot to be desired? Then buy some new for you and your guests to sit on. You can find decent seating for a reasonable price these days so you don't even have to worry about your budget. Obviously the bigger your budget, the more decadent your seating options can be.
Buy Good Equipment
Buy good equipment to help you to maintain your garden and you'll find the job so much easier and more enjoyable. Research the kind of equipment and read reviews to help you.
Use Apps to Help
There are so many apps you can download to help you get the job done to a much higher standard. There are apps that will give you tips, apps that will tell you when to water certain plants, and so much more. Take a look and see what suits you! Many of them are a free – like having a gardener in your own pocket.
Hire Somebody
If you want a really quick and easy way to update your garden, hire somebody. Sure it'll cost a lot more, but you'll get it done faster than you can pick out some nice geraniums. Take a look at online ads or even on local noticeboards to find somebody suitable. Bear in mind that if you go the cheap route, you might end up spending more money fixing somebody else's shoddy work.
These tips will help you to have a brand new looking garden in literally no time at all. If you're sick of your garden or just fancy a change, these are the tips to use. Please let me know what you think of them afterwards by leaving a comment below. I'd love to hear from you!


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Adorable Wedding Ceremony Cake Topper Patterns
Fall is one particular of the prettiest occasions of the 12 months to strategy for your particular wedding day. The cool fall air and bright colors swarovski schmurk generate a whimsical setting for a single of the most critical days of your daily life. Considering that she was a little woman the bride has been dreaming about the ideal wedding ceremony dress. Get a seem at some of this yr's gorgeous fall gowns, for your excellent fall wedding ceremony.
One each and every opposite side, string a single piece of swarovski heart bead, followed by one piece of 3mm bicone bead. Pull the thread tightly. Tie a double dead knot.
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Try storing your silver and other metallic jewellery in plastic air tight bags. These bags maintain air from contacting your treasured jewelry, which, in turn, permits the jewellery to last longer. If you do this basic and low-cost procedure of storing your metallic jewellery, they will final longer and search far better.
On the sensible side, a head band may be a lot more appropriate for an infant than a hairpin, seeing that they have extremely tiny hair that can attach to. Also, you should search at the extra attributes presented. For instance, some child hair products are no-slip, consequently you don't have to fret swarovski schmurk about reattaching them (which can be a struggle) or losing a pair.
If you need to really go for the high heels, try them at house for a lengthy time. Do not wait for the wedding ceremony swarovski schweiz day, simply because you will require to modify with the sneakers. If you wear the footwear for a while prior to the wedding day, then you can feel a lot more relaxed on the massive day, and you will also come to feel the dilemma right away.
Some crystal jewelry sets come with add-ons -- like credit card instances -- that can fit appropriate in your designer handbag. You can even opt for exciting things -- like an complete crystal desk set -- so that you can feel entirely glamorous even when you're putting swarovski schweiz online in overtime at the workplace.


text:
My 5th Birthday
I'm 5 years old today!
My day started out with walkies. We walked for a whole hour! This is a brand new neighborhood so there are lots and lots of new peemails!
The yellow house behind me is where mom and I live. We're on the second floor.
Love ya lots♥


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- Please select a date to see the proper prices!
Description of the accommodation:
Rooms, services Desert Trails Luxury Suites Hobbs would be pleased to host you for a few days trip or a longer holiday in Hobbs. The hotel is offering eight tastefully furnished rooms to those seeking accommodation in Hobbs. The bar has excellent atmosphere for a relaxed evening talk or a personal meeting. In the safe your valuables can be the safely secured. An exact and detailed list of equipment in the rooms and of the services provided by Desert Trails Luxury Suites Hobbs you will find on the information sheet below, including any applicable additional fees.
Payment Advance bank card payment or credit card guarantee may be required for the reservation, depending on the chosen date, room and price.
Arrival, opening hours The personnel of the hotel can speak with you in English.
Desert Trails Luxury Suites Hobbs rooms Rooms
- Please select a date to see the proper prices!
Accommodation services
Pet friendly, Bar, Safe deposit box
Bathrobe, Hairdryer, Fridge, Microwave oven, Mini-bar, Washing machine, Tea/coffee-maker


text:
Learn at a pace and place that suits you
- Learn in bite-sized chucks
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- We don't move on until you're ready to
What are Social Media Tools?
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- Generate new sales and business opportunities by using the right tools.
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A look at the best desktop and mobile image creation and editing tools. Learn how to create powerful images for your social media posts in minutes.
How to create high quality/low cost video on desktop and mobile.
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How to find business opportunities and protect your reputation online. Find out what listening tools are right for your business.
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An in-depth look at what analytical tools you can use to measure the success of your social media efforts and tools that will help you increase your Social Media ROI.
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MCW Slamboree took place in Joppa, Maryland. The event took place on June 10, 2016. The event featured Kevin Nash and Scott Hall.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Bo Nekoda defeated Brandon Scott
- Fenix Fury defeated Cousin Clay
- Black Wallstreet (Napalm Bomb & Solo) vs. Guns for Hire (Bill Collier & [[]] ends in a Double Count Out
- Chuck Lennox defeated Jeremiah (w/ Andy Vineberg)
- Brittany Blake defeated Renee Michelle and Kimber Lee to win the MCW Women's Championship
- Sean Studd (w/ Andy Vineberg) defeated Rayo
- Punk Rock All Stars (Drake Carter & Shaun Cannon) (c) defeated Hell Cats (Sexy Steve & Jimmy Starz) and The Ecktourage (Dirty Money & Eric Chapel) to retain the MCW Tag Team Championship
- Lio Rush defeated Adam Brooks
- Johnny Crab Cakes, Damien Sandow, The Bruiser & Colt Cabana defeated Kings of Maryland Wrestling (King McBride, Ken Dixon & Dixon Line (Rob Locke & Joe Keys))


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The people who wish to lead a guild of any type can read on this article. I will try my best to write all the things I know. After several years of playing, I can be a veteran player in Wow. I have leaded a guild in Wow. I desire to talk about how to manage a guild in Wow in this article. You should know the guild type first. Before you could manage a guild successfully to consider the type of the guild. The guilds are different from its members. You can get many types of the guilds. You need to come to a decision what type you can take.
The guild leader will decide what things might be done in the guild. The people with the same interest will gather and finish the same task. If you created a progression raid guild you could invite people who like to raid.
There is PVP guild as well as leveling guild you'll be able to create. The guild might be named as reported by the intent behind the players. Most are the casual guilds. You'll be able to see some uncommon categories of guilds in the game. The high level players often join the uncommon guilds for uncommon purpose.
Some tasks can only be finished by the high level players. The high level players are much better than the new game players. They can play a big part in the game. For certain i will give further description to the several guild types I am interested in.
Raiding Guilds
A guild master of the raiding guild will do lots of work. One can find even more work to do than you can actually imagine. You need to have a few people as your officer in the beginning.
They are able to help you make decision run loots and do other things. You are going to have your information put on raiding guild websites. You'll want to have a good management of the guild. You'll want to pick out the focused process to go in the guild. Your decision will affect the rewards the members can get. Make sure you decide to run a casual guild or you are likely to focus more on the friends.
Loot System
The loot system is determined by how casual the guild is. Every guild has its own loot system. Its unique and special. The biggest feature of the loot system would be fair. The gamers who devote the most get the most rewards. The player with better ability will get more experience from the guild. This is fair to every player. The players who don't get loot will probably have no words to say.


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CapSure is an innovator in the Visitor and Identification Management marketplace. Since 2001 the company has been dedicated to providing best in class solutions for identifying, credentialing, and tracking the general public. The flagship product suite CapSure EnterpriseTM, CapSure CommunityTM, and CapSure MobileTM are the products of thousands of man-hours of research and development, the upfront involvement of global security personnel, and input from leading industry access control providers. The first version was released in 2002 and has processed over 1 million transactions through its software. CapSure provides all of the tools needed to streamline the admittance process while maintaining optimum security by integrating features like driver's license scanning, visitor and contractor vehicle tracking, voicemail recognition, visitor pass printing and web based access control. CapSure also gives users/employees the ability to manage their own visitor lists and privileges via the web.
Developed in the Microsoft .net environment, CapSure is a robust, scalable, user friendly visitor management program that is applicable to communities with single family homes as well as high rise complexes. CapSure provides communities and corporations with the tools necessary to accurately and dependably schedule and process visitors through busy entry points with detailed historical tracking.
CapSure offers onsite solutions as well as software as a service (SaaS) visitor processing offerings, hosted in our secure data center. CapSure has achieved significant acclaim in the security industry and has established strategic partnerships with industry leaders. CapSure's customer base includes premier Fortune 500 accounts as well as secure communities and is sold through strategic distribution partners with a local presence.


text:
The video shows shocking videos of various places and some of the astonishing things that happened. In Kaohsiung, a motorcycle flew over 10 feet into the air. A freight airplane at the Taoyuan International Airport that weighed over 10 tons was lifted off the ground. A 600-ton Ferris wheel rotated around 17 times its normal speed by the force of the wind alone.
The video has been viewed over 770,000 times and has been shared by over 9,000 users. Let's all hope that Taiwan recovers from this devastation.
Watch the video, share the article and let us know what you think in the Today in Manila comments section below!
Shocking images in Taiwan after Typhoon Soudelor hitsThe scale of damage in the wake of Typhoon Soudelor has left no...
Posted by CCTVNews on Sunday, August 9, 2015
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|Publication number
|Publication type
|Application number
|Publication date
|Aug 22, 2006
|Filing date
|Jul 31, 2002
|Priority date
|Jul 31, 2002
|Fee status
|Also published as
|Publication number
|Dwight D. Riley
|Original Assignee
|Hewlett-Packard Development Company, L.P.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (14), Non-Patent Citations (5), Referenced by (8), Classifications (10), Legal Events (6)
|External Links: USPTO, USPTO Assignment, Espacenet
This application is related to the following commonly owned U.S. patents and patent applications, which are hereby incorporated in their entirety by reference for all purposes:
U.S. Pat. No. 6,266,731, entitled "HIGH SPEED PERIPHERAL INTERCONNECT APPARATUS, METHOD AND SYSTEM," by Dwight Riley and Christopher J. Pettey;
U.S. patent application Ser. No. 09/747,422, entitled "HIGH SPEED PERIPHERAL INTERCONNECT APPARATUS, METHOD AND SYSTEM," by Dwight Riley and Christopher J. Pettey, filed Dec. 22, 2000; and
U.S. patent application Ser. No. 10/184,164, entitled "POINT-TO-PONT ELECTRICAL LOADING FOR MULTI-DROP BUS," by Michael Y Chan and Dwight C. Riley, filed Jun. 28, 2002.
Not Applicable.
Not Applicable.
1. Field of the Invention
The present invention generally relates to computer interconnects and more particularly to using an interconnect as a cross-connect for a distributed system.
2. Description of the Related Art
Early conventional computer systems used a single interconnect, to which the various components of the computer system were connected. The interconnect known today as an Industry Standard Architecture (ISA) interconnect was used in many early computer systems. The name ISA for these interconnects was an afterwards-developed name for a previously unstandardized interconnect used in IBM PC/AT systems. With the advent of interconnects such as the Peripheral Components Interconnect (PCI) interconnect, conventional computer systems began to use a host interconnect for connecting the processor to an interconnect to connect to other components, such as adapter cards. A Host/PCI interconnect bridge typically connects the host interconnect and the PCI interconnect.
The PCI 2.2 specification, a copy of which is incorporated in its entirety by reference, allows for connecting multiple PCI interconnects in an interconnect hierarchy, with PCI-to-PCI bridges. Transactions are routed by the PCI-to-PCI bridges based on an enumeration of the interconnect hierarchy performed at initialization of the computer system. Transactions typically contain information indicating the destination interconnect number and device, which allows the bridges to determine the transaction routing.
Other interconnect architectures have been developed that can also use bridges to interconnect multiple interconnect segments. Further, the PCI-X extension to the PCI standard, as defined in the PCI-X 1.0 specification, a copy of which is incorporated herein in its entirety by reference, modifies the behavior of interconnect bridges in a PCI-X environment.
Additionally, distributed interconnects have been developed such as Ethernet, Infiband, and Fibrechannel. These distributed interconnects typically do not use bridges for connecting multiple interconnects or networks, but use devices such as routers, which route transactions across a network of connected interconnects. Typically, such distributed interconnects do not act as a single interconnect hierarchy, but as multiple connected systems.
Today, the computer industry is looking for a cost effective way to design distributed server blade type architectures. A blade server architecture typically uses an ultra dense collection of processor cards, known as "blades," connected to a common power supply on trays in a rack. Unlike traditional multiprocessor systems, in which a single operating system manages the multiple processors in a unified execution system, a blade server system generally is a collection of independent computer systems, providing benefits such as lower power usage over traditional separately configured computer systems.
In their simplest form, a blade would be a processor and memory. However, conventional blades today are typically a full computer system, with a processor, memory, video chip, etc., all on a board getting power and Ethernet connections from a backplane. Typical blades do not contain interconnect connectors, such as a PCI connectors, because of a perceived difficulty in extending the PCI interconnect across the backplane. Because blades, by definition, are single cards, other conventional PCI devices are not typically connected via PCI slots as in typical desktop systems.
The ability to use interconnects such as PCI in blades for connection to external PCI devices has been desired, to allow reuse of existing PCI hardware and to allow reducing the number of components on the blade.
Briefly, according to one embodiment, a distributed computer system comprises a first subsystem, a second subsystem, and a cross-connect subsystem. The cross-connect subsystem is couplable to the first subsystem and the second subsystem. The cross-connect subsystem comprises a cross-connect interconnect, couplable to the first subsystem and to the second subsystem, the cross-connect interconnect transparently aliasing transactions between the first subsystem and the second subsystem as transactions on the cross-connect interconnect.
In a further embodiment, the first subsystem comprises a first interconnect and the second subsystem comprises a second interconnect, where the first interconnect, the second interconnect and the cross-connect interconnect operate according to a common interconnect protocol.
In a further embodiment, the common interconnect protocol is the PCI-X protocol.
In another further embodiment, the cross-connect subsystem further comprises a first cross-connect connector of the cross-connect interconnect, couplable to the first subsystem interconnect, a second cross-connect connector of the cross-connect interconnect, couplable to the second subsystem and a routing engine, couplable to the first cross-connect connector and to the second cross-connect connector, the routing engine transparently aliasing transactions between the first subsystem and the second subsystem as transactions on the cross-connect interconnect.
In another further embodiment the first subsystem and the second subsystem appear to each other as being directly connected by an interconnect bridge.
In a yet further embodiment the cross-connect subsystem further comprises a cross-connect processor coupled to the routing engine, an operating system executed by the cross-connect processor, the operating system comprising a processor-executable code to create an aliasing table for use by the routing engine, a processor-executable code to update the aliasing table responsive to coupling either of the first subsystem or the second subsystem to the cross-connect subsystem, and a processor-executable code to update the aliasing table responsive to decoupling either of the first subsystem or the second subsystem from the cross-connect subsystem.
In another further embodiment, the cross-connect subsystem appears to the first subsystem and the second subsystem as an interconnect bridge.
In another further embodiment, the first subsystem comprises a first processor, a first processor interconnect coupled to the first processor, and a processor interconnect to interconnect converter, the first subsystem couplable to the cross-connect subsystem through the first processor interconnect to interconnect converter.
In another embodiment, transactions on the first interconnect and the second interconnect include a plurality of cache coherency attributes.
In a yet further embodiment, the second subsystem is a shared memory subsystem. The shared memory subsystem interprets the cache coherency attributes on transactions from the first subsystem to preserve cache coherency.
In a yet further embodiment, a third subsystem shares the shared memory subsystem with the first subsystem, the cross-connect interconnect transparently aliasing transactions between the third subsystem and the second subsystem as transactions on the cross-connect interconnect. The first subsystem and the third subsystem can be invisible to each other.
In another further embodiment, the shared memory subsystem allocates a first portion of the shared memory subsystem to the first subsystem and a second portion of the shared memory resource to the third subsystem.
In another further embodiment, the cross-connect subsystem is a backplane of a blade server. In another further embodiment, the first subsystem and the second subsystem are blades for a blade server.
In another embodiment, a first interconnect of a first subsystem, coupled to a cross-connect interconnect via a first interconnect interface having a first cross-connect device number, the cross-connect interconnect having a cross-connect interconnect number, is assigned a first interconnect number, a second interconnect of a second subsystem, coupled to the cross-connect interconnect via a second interconnect interface having a second cross-connect device number, is assigned a second interconnect number. A transaction from a first device of the first interconnect, having a first device number, received on the first interconnect interface is converted to be destined to a second cross-connect interconnect device number of the cross-connect interconnect. After transmittal across the cross-connect interconnect, the transaction is converted to be destined for a second device of the second interconnect and sent on the second interconnect. The conversion of the transaction to the second cross-connected device can be done at the first interconnect interface. The conversion to be destined to the second device of the second interconnect can be done at the second interconnect interface.
In a further embodiment, an alias table is updated to map the first device number and the first interconnect number to the first cross-connect interface device number and cross-connect interconnect number. The alias table is also updated to map the second device number and the second interconnect number to the second cross-connect interface device number and cross-connect interconnect number.
A better understanding of the present invention can be obtained when the following detailed description of the preferred embodiment is considered in conjunction with the following drawings, in which:
A technique is disclosed herein for enhancing the operation of computer system interconnects that use the extensions to the Peripheral Component Interconnect specification (hereinafter PCI-X interconnects), as well as logic circuits and signal protocols thereof. For illustrative purposes, embodiments are described herein for computer systems using Intel Corporation microprocessor architectures and certain terms and references are specific to such processor platforms. PCI-X and the enhancements described herein, however, are hardware independent, and may be used with any host computer designed for this interconnect standard. As will be appreciated by those skilled in the art of computer systems, the disclosed embodiments can be adapted and applied to any computer platform utilizing the PCI-X standard. Further, although the following is described in terms of PCI-X interconnects, other interconnect architectures and protocols, such as the PCI Express (formerly known as 3GIO) interconnect architecture and protocol being promoted by Intel Corporation, Compaq Computer Corporation, Microsoft Corporation, IBM Corporation, and Dell Computer Corporation, could also be used.
Further, the term "interconnect" as used herein refers generally to connections or pathways between two or more points in a computer system and includes bus implementations, such as conventional PCI busses, as well as non-bus implementations, such as serial interconnects, switches or hubs. However, unless otherwise expressly indicated, the term "interconnect" as used herein does not include distributed interconnects such as Ethernet or InfiniBand.
Turning now to
A conventional blade server BS1 as shown in
The tray 150 typically transparently passes power and networking connections between each of the blades 110, shown in
One perceived advantage of blade servers is the ability to provide ultra dense packing of competing resources in a single blade server, such as the server BS1 of
In a disclosed embodiment, illustrated in
Because the blades 212, 222, and 232 and the backplane 200 use the PCI protocol for networking, the CPU blades 212 can be reduced to a CPU and memory, without the need for other devices conventionally connected as PCI devices in a non-blade server environment that are typically contained on the blades 110 in the conventional blade server BS1 of
Although not shown in
Turning now to
Blade 310 is a CPU blade as illustrated in
Blade 320, in this example a disc blade, contains a conventional disc and disc controller 322 connected to a PCI interconnect 329. For clarity of the drawing, the disc and disc controller are shown as a single element 322, but can be implemented as separate units.
Blades 310 and 320 are connected to backplane 300 via PCI interconnects 319 and 329, which connect to backplane connection points 340 and 350, respectively. The backplane 300 contains a management CPU 302, for controlling the backplane 300 and for allocating device blades to CPU blades in the blade server BS2, and a memory 304, connected to a host interconnect 306. The host interconnect 306 is connected to a cross-connect PCI interconnect 339 by a host/PCI bridge 308, allowing the CPU 302 to control devices connected to the PCI interconnect 339. Other techniques can be used for controlling devices connected to the PCI interconnect 339. The connection point 340 connects the PCI interconnect 319 of CPU blade 310 to the PCI interconnect 339, and the connection point 350 connects the PCI interconnect 329 to the PCI interconnect 339 as is described in more detail below. A routing engine 330 is connected to the PCI interconnect 339 for aliasing transactions between the PCI interconnect 319 and the PCI interconnect 329 as is described in more detail below. One skilled in the art will recognize that other devices can be connected to the PCI interconnect 339 and the host interconnect 306.
The connection points 340 and 350 allow transactions between the CPU blade 310 and the disc blade 320. The connection point 340 makes the CPU blade 310 appear as a device to the PCI interconnect 339, while the connection point 350 makes the disc blade 320 appear as a device on the PCI interconnect 339. The connection points 340 and 350 interact with the routing engine 330 to alias transactions across the PCI interconnect 339 between the connection points 340 and 350. Thus, the backplane 300 allows connecting the blades 310 and 320 into a single interconnect hierarchy.
In one embodiment, the backplane 300 appears as a PCI-to-PCI bridge to the CPU blade 310 and the disc blade 320 during enumeration of the PCI interconnect hierarchy by the CPU blade 310 and the disc blade 320. A ROM or boot image can be located on the CPU blade 310 or on the backplane 300, either on the cross-connect interconnect 339 or in the memory 304. Once a configuration for the distributed system BS2 is established by the management CPU 302 via management software, the ROM or boot image is initialized before the configured blade(s) are permitted to be powered up. Once the ROM or boot image is configured, the CPU blades 310 boots in a conventional manner and configures those resources to which it is connected without any knowledge of the backplane 300 or the cross-connect interconnect 339. The PCI interconnect 339 is invisible or transparent to both the PCI interconnect 319 and the PCI interconnect 329. Thus, transactions on the PCI interconnect 339 are also invisible to the blade PCI interconnects 319 and 329. Further, interconnects 319 and 329 and transactions on the interconnects 319 and 329 are invisible to other blade devices connected to the PCI interconnect 339.
Turning to
In the configuration of
In one embodiment, these attributes are provided in a PCI-X attribute phase, using the AD[63::32] lines, defined as reserved, driven high in the current PCI-X 1.0 specification, a copy of which is incorporated herein in its entirety by reference.
Turning to
The transaction is then placed on the PCI interconnect 319 of the processor blade in step 620 after traversing the host interconnect 316 and Host-to-PCI bridge 318. Connection point 340 then, in step 630, positively claims the transaction in the conventional fashion. In one embodiment, in step 640, connection point 340 obtains routing information, which can be an alias table, from the routing engine 330 upon claiming the transaction on PCI interconnect 319. In one disclosed embodiment, the routing information is stored by the connection point 340 for future transactions between the same initiator and target device. Such an embodiment could provide performance enhancements, by avoiding the time delay needed for transactions between the connection point 340 and the routing engine 330. One skilled in the art will recognize that the routing information can be stored using multiple techniques.
Regardless of the technique for determining the routing information, the connection point uses the routing information in step 650 to generate a transaction across the cross-connect interconnect 339 with the connection point 350 to which the disc blades PCI interconnect 329 is connected. The PCI transaction can be a conventional PCI transaction between connection points 340 and 350, modifying the original transaction accordingly to alias the original initiator and target data using the device numbers of the connection points 340 and 350 as necessary.
In step 660, the connection point 350 claims the transaction, using conventional PCI techniques. For clarity of the description, conventional PCI signaling is not further described. The connection point 350 then, in step 670, converts or aliases the transaction from a transaction on the cross-connect interconnect 339 into a transaction on the disc blade 320's PCI interconnect 329. Similarly, actions by the connection point 350, as were performed by connection point 340, use routing information supplied by the routing engine 330 to realias the transaction as being for the PCI interconnect 339.
Then, in step 680 the transaction is placed on the PCI interconnect 329. Although not shown in
The routing engine 300 of
Further, although shown in
The foregoing disclosure and description are illustrative and explanatory thereof and various changes in the components, circuit elements, circuit configurations, and signal connections, as well as in the details of the illustrated circuitry and construction and method of operation may be made without departing from the spirit and scope of the invention.
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|Processor bridge with dissimilar data registers which is operable to disregard data differences for dissimilar data write accesses
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|Compaq Computer Corporation
|Apparatus, method and system for a computer CPU and memory to high speed peripheral interconnect bridge having a plurality of physical buses with a single logical bus number
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|International Business Machines Corporation
|Apparatus and method of PCI routing in a bridge configuration
|Feb 28, 2001
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|Lsi Logic Corporation
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|Multiple processor cards accessing common peripherals via transparent and non-transparent bridges
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|System and method for scalable switch fabric for computer network
|"Aliasing" (Definition of), The American Heritage College Dictionary, 2002, 4th Edition, p. 34.
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|Child, Jeff, "Switched-Bus Schemes Marry Speed to Legacy I/O," Apr. 2000, Penton's Embedded Systems Development, p. 26 30.
|Jacobs, April, "PCI-X Ups the Ante on Buses," Nov. 30, 1998, Computerworld, ABI/INFORM Global, pp. 61-62.
|O'Connor, Richard, "High-Performance Interconnect Sought," May 8, 2000, Electronic Engineering Times, p. 104 and 109 (2 pages).
|Citing Patent
|Filing date
|Publication date
|Jul 6, 2007
|May 8, 2012
|Hewlett-Packard Development Company, L.P.
|End-to-end flow control in a network
|Jul 31, 2007
|Jul 24, 2012
|Hewlett-Packard Development Company, L.P.
|Memory expansion blade for multiple architectures
|Jul 31, 2007
|Jan 1, 2013
|Hewlett-Packard Development Company, L.P.
|Memory controller with multi-protocol interface
|Jun 29, 2009
|Feb 4, 2014
|Hewlett-Packard Development Company, L.P.
|Organizing and managing a memory blade with super pages and buffers
|Jul 6, 2007
|Jan 8, 2009
|Brownell Paul V
|End-to-end flow control in a network
|Jul 31, 2007
|Feb 5, 2009
|Bresniker Kirk M
|Memory controller with multi-protocol interface
|Jul 31, 2007
|Feb 5, 2009
|Bresniker Kirk M
|Memory expansion blade for multiple architectures
|Jun 29, 2009
|Jan 6, 2011
|Hewlett-Packard Development Company, L.P.
|Organizing and managing a memory blade with super pages and buffers
|U.S. Classification
|710/313, 710/314, 710/311, 710/312
|International Classification
|Cooperative Classification
|European Classification
|Jul 31, 2002
Owner name: COMPAQ INFORMATION TECHNOLOGIES GROUP, L. P., TEXA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:RILEY, DWIGHT D.;REEL/FRAME:013163/0284
Effective date: 20020730
|Jun 8, 2005
Owner name: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P., TEXAS
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:COMPAQ INFORMATION TECHNOLOGIES GROUP, L.P.;REEL/FRAME:016313/0854
Effective date: 20021001
|Jul 28, 2009
|Certificate of correction
|Feb 22, 2010
|Fee payment
Year of fee payment: 4
|Jan 23, 2014
|Fee payment
Year of fee payment: 8
|Nov 9, 2015
Owner name: HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP, TEXAS
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.;REEL/FRAME:037079/0001
Effective date: 20151027


text:
Holman CDF Freedom Schools Program Overview
The Children's Defense Fund Freedom Schools® program provides summer and after school enrichment that helps children fall in love with reading, increases self-esteem, and generates positive attitudes toward learning. Children are taught using a model curriculum that supports children and families around five essential components: high quality academic enrichment, parent and family involvement, civic engagement and social action, intergenerational leadership development, and health.
Building on the successful programs in 2012 and 2013, by Read Lead (www.readlead.org), Holman will become a third site, managed by Read Lead, to provide this enriching educational opportunity to 60 scholars between the ages of 5-13 during the summer of 2015. With a 10:1 student to teacher ratio, these young scholars will experience a program that will ensure they are equipped with the necessary skills to be able to be successful in life. During the program, trained servant leaders will also provide opportunities and instruction in leadership development, science and technology, the arts and sports.
This exciting experience will build our scholars' self-esteem, increases their love of reading and introduces them to various activities not provided by the traditional school system. In six weeks of learning, scholars will read over 80 books that are developmentally appropriate, reflect children's own images, relate their authentic history, culture, and heritage through the eyes of children, introduce children to adults and children who make a difference in the lives of others, offer encouragement to become involved in community service, help children explore fundamental issues related to self-esteem and expand their capacity to dream and to believe they can make their dreams reality.
Program Dates:
June 26, 2017 – August 4, 2017 (6 weeks)
Program Goals
- To instill in children, youth, and young adults intrinsic values of reading, high achievement, community service, and social action to create well rounded globally minded citizens.
- To increase parent and family involvement by engaging parents as volunteers but also as adult learners and advocates through parent meetings and trainings that run parallel to the student program.
- To develop intergenerational leaders in global and civic leadership, social justice, and social entrepreneurship.
- To connect the complex needs of children and families to the rich resources of the local community by introducing them to the local library, neighborhood cultural centers, and science and technology museums.
- To build healthy lifestyles in our children to foster a healthy body and mind. We do this through providing nutritious meals twice each day of the program and by leading fun physical activities.
Partners for Freedom
We thank our partners for their financial commitment to making this program possible. Our growing list of "Partners for Freedom" include, among others:
- Supervisor Mark Ridley-Thomas
- The Holman Permanent Endowment
- Senator Holly Mitchell
- The Aids Healthcare Foundation
- Anonymous Partners
Volunteers for Freedom
We thank our dedicated volunteers who will serve and care for the scholars participating in the program. Your time and gifts are invaluable.
We look forward to bringing high quality summer educational opportunities to our community. We deeply appreciate the growing list of "Partners for Freedom" and volunteers for their commitment. Blessings beyond!
Further Information About Freedom Schools
- From Freedom Summer to Freedom School by Marian Wright Edelman, President of the Children's Defense Fund
- Read Lead Freedom School Presentation (PDF)
50 Years On, Freedom Schools Still Teaching Most Vulnerable
Gewn Ifill's PBS NewsHour segment: 50 Years On, Freedom Schools Still Teaching Most Vulnerable, aired Friday, August 8th. She highlights the importance of the CDF Freedom Schools® Program, which builds on the Freedom Schools of the Civil Rights Movement 50 years ago during Freedom Summer.
The CDF Freedom Schools program boosts student capacity and motivation to read, connects the needs of children and families to resources within their communities, and helps to close racial and economic achievement gaps. The six-week summer and after-school programs include five basic components: an integrated literacy curriculum, parent involvement, child service and civic engagement, intergenerational leadership development, and nutrition.
The CDF Freedom Schools model incorporates the totality of the Children's Defense Fund's mission by supporting children to excel and believe in their ability to make a difference in themselves and their families, schools, communities, nation, and world. "Once you know how to read it's very hard to make you a slave," says Marian Wright Edelman.
Since the program began in 1995, more than 125,000 children have had the CDF Freedom Schools experience and more than 15,000 college students, site coordinators, and project directors have been trained to deliver this empowering model.
CDF Freedom Schools program sites work hard to ensure each child is equipped with the necessary skills to succeed in life. This summer 12,745 children in 107 cities and 29 states were able to benefit from the program. Your support today will help level the playing field for every child!
For more information on how you can get involved please contact:
Allison Merfeld
Manager for Program Operations
Watch and share the PBS NewsHour segment 50 Years On, Freedom Schools Still Teaching Most Vulnerable!
With Urgency and Determination,
-Children's Defense Fund


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Tyddyn Derwen
Tyddyn Derwen, sleeping 5, is a recently restored delightful and secluded cottage. Nestling in woodland and overlooking a field it is completely tranquil . The property is in the heart of the Bodnant Estate, with easy access to the various glorious walks along private paths on the Estate.
The cottage has been renovated to a very high standard and is decorated in a traditional style. There is a single bedroom with en suite shower room on the ground floor, and a double bedroom and a twin bedroom on the first floor sharing a bathroom. There is a large sitting room with beamed fireplace (using oak from the Estate woods) and a well-appointed kitchen/dining room with oak floor.


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Seth Godin has a notion that corporate philosophy will change if we quit referring to "Human Resources" as such, and instead re-christen it "Department of Talent." He says the idea of HR came about in an industrial age, and demeans employees by … [Continue reading]
Talent Revisited
Speed Kills
During one of my recent travels, I missed out on one of those magic parenting moments. My wife told me about it later, and it cracks me up. My son had his toy dinosaurs all gathered together. The biggest one was laying on its side. Deceased. … [Continue reading]
{{myquote|If you think a blog is the only thing you need, then good luck cutting your steak with a spork.}} (From Social Media Explorer) … [Continue reading]
It can be a little unnerving at times when your parents crash your party. Here I have this nice little non-blog website, where I share my thoughts with a couple dozen of you out there, and most of the time I completely blank on the fact that my … [Continue reading]
I'm in training today, and as much as I learn from being in a session, I learn even more from conducting one. Leading a class forces you to bone up on not just the immediate subject matter, but also the secondary pieces that might come up in … [Continue reading]
What's In a Name?
I've been known by many names in my life. Been called a few too - some of those deserved. The name you answer to has a powerful affect not just on you, but the others with whom you'd like to relate, in both business and pleasure. From birth, I … [Continue reading]


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According to Hindu Vedic calender, this will be the 5242th birth aniversary of lord Krishna which is going to be celebrated as "Krishna Janmashtami" (श्रीकृष्ण जन्माष्टमी) on 5th Sep 2015. As legends says, lord Krishna was born on this day in a Jail to order to destroy and counteract against all evils and bad forces from the face of the earth. The festival is observed in all over India, but in Mathura and Vrindavan which are believed to be the birth place of Lord Krishna, this festival is celebrated in most unique and enthusiastic way. Get Janmashtami 2015 Shubh Muhurat Timings, Vrat-Fasting Time, and Puja Vidhi to be followed while worshiping Krishna on this auspicious occasion. We have posted Shri Krishna Janmashtami Muhurat, Puja Vidhi, Vrat Timings and all stuff you gonna need to celebrate Janmashtami 2015.
- Don't Miss:- Krishna Janmashtami Wishes Quotes Messages Wallpapers & SMS
- Don't Miss:- Happy Krishna Janmashtami HD Wallpapers, Images & Greetings Cards
Janmashtami 2015 Shubh Muhurat Date Timing Puja Vrat-Vidhi
- Janmashtami 2015 Date:- 5th Sep 2015 (Saturday)
- Janmashtami 2015 Auspicious Timing When Lord Krishna Was Born:- 12:16 AM on 6th Sep 2015.
- Janmashtami 2015 Nishita Puja Muhurat Time = Starts From 5th Sep on 11:53 PM to 6th Sep till 12:39 AM. (Total Muhurat Duration: 0 hours and 45 Mins)
- Janmashtami 2015 Parana Timings To Break Fast = Anytime After 06:00 AM on 6th Sep 2015 (After Sunrise).
- Dahi Handi Will Be Observed on 6th Sep After Sun Rise.
Important Notes:-
- "Nishita Kala" is the most auspicious time to perform Krishna Puja at midnight.
- "Parana Kala" is the auspicious time to be follwed for braking fast for Janmashtami.
- The festival is also celebrated as Krishnashtami, Gokulashtami, Ashtami Rohini, Srikrishna Jayanti and Sree Jayanthi in different parts of the country.
- Note that above timings are applicable only in India as per as Indian Standard Timings (IST). For Janmashtami Muhurat Timings in USA, UK, Canada, UAE, Australia, Malaysia, Indonesia, Etc, please check back local timings as comparable to above timings.
Janmashtami Fasting Rituals & Rules:-
- Fasting Should be started from the Ashtami Date till the end of its time which is 03:55 AM on 5/Sep/2015 and ends on 03:01 AM on 6/Sep/2015.
- Therefore on 5th Sep fast should be started right from the morning and should be break on next day sun rise when Ashtami tithi is over.
- No grains or any food made up of grains should not be consumed during fasting period. However food made of milk, fruits can be consumed in small amount in the evening time.


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Sleep is very important to your overall health, and particularly, to weight loss. Going to bed earlier, and waking up earlier will realize weight loss results in only a week.
How your sleeping habits will help you lose weight
Poor sleeping habits actually contribute to weight gain. It is a fact that people who are deprived of sleep will gain 3 pounds in a day.
When you are deprived of sleep, you don't have the energy you would normally have when you have a healthy night's sleep. This produces negative results in two ways.
First, people who are not well rested tend to be emotionally unstable, or, just plain grouchy. Not being capable of making intelligent decisions, the grouchy person will make poor food choices. Also, people who are in this state of mind may have the tendency to over eat, as a habit of relieving their anxiety. What happens is, a person deprived of sleep steps back into the old habits that caused them to gain weight in the first place.
Second, the lack of energy from lack of sleep causes people to be less active and less mobile. When this happens, the person doesn't have the energy to do the common things like walking, much less, exercise.
Now you see how going to bed late and sleeping late can hurt your ability to lose weight. Change your sleeping habits, and you will see at least 10 pounds disappear in a week.


text: dear bros, while driving, i brushed my cars right hand side both the wheels onto a broken divider stone which had came out loose on the road. i had damaged both- front and rear steel rims as well as tires and my rear tire is flat in spite it is tubeless. and rear steel wheel is bent and wheel caps are bent both of them. speed 40kmph. the car vibrated twice with little dent on side body panel below doors. my questions are : 1. will my wheels and tires be replaced under insurance ? 2. are my brakes, axle and other parts be damaged ? 3. can i fit in oem alloy wheels , even tough i have steel wheels ?


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I find dat the spells you will choose at champion selection are so important you might as well just use those instead of your Q,E,R. notice that I left out the W because well W is such a good skill, dat riot banned it from league...... but you still get to use it anyway. Lets face it ya need to be gettin outa dat CC BABEEE. $$$
This is the guide to the man in league that can get more *** than a public toilet seat. DA MIGHTY BUTT PIRATE. Da Pirate is one of the few champions in league that has a hidden passive. Here is a step by step process to get it. Cause it is worth it. Step 1: go to youtube and search for "Pirates of the carribean theme song" Step 2: thank the producers of the pirates of the carribean movie for making this awesome track and making the butt pirates hidden passive possible. Because if you can successfully play and listen to the theme song throughout the entire match in league when you play as g-g-g-gasblaster gankplank. You will win Da game. And the little bunny lived happily ever after. Step 3: wow i just messsed up there "facepalm"


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LOS ANGELES (Reuters) - Former National Football League quarterback Erik Kramer tried to commit suicide by shooting himself at a motel in the Los Angeles area, NBC News reported.
Kramer's former wife, Marshawn Kramer, told NBC News late on Wednesday that he suffered from depression, which she thought was linked to his playing days in what could be another case of a retired player being plagued by head injuries after retirement. She could not be reached for further comment.
Los Angeles County Sheriff's Department spokeswoman Deputy Crystal Hernandez on Thursday confirmed deputies went to check on a man on Tuesday night at a motel in Calabasas and found he had a gunshot wound from an apparent suicide attempt. She declined to release the man's name due to patient confidentiality rules but NBC News identified him as Kramer, 50, citing unnamed law enforcement sources and Marshawn Kramer.
He was taken by helicopter to a hospital with a non-life threatening injury.
Kramer played for the Atlanta Falcons, Detroit Lions, Chicago Bears and San Diego Chargers between 1987 and 1999. His best season was 1995 with the Chicago Bears when he passed for 3,838 yards and 29 touchdowns.
Kramer and his ex-wife have a 17-year-old son and Marshawn Kramer told NBC News, "He's such a good dad and he would not do this to his son. This is brain injury."
In the past decade, the families of some NFL players who committed suicide, including stars Junior Seau in 2012 and Dave Duerson in 2011, have blamed their deaths on brain injuries. A study of Seau's brain revealed he suffered from chronic traumatic encephalopathy, a debilitating condition caused by jolts to the head that can lead to aggression and dementia.
Research linking collisions on the field to the disease has already prompted the NFL to make changes, including requiring teams to keep players who have taken hits to the head off the field if they show certain symptoms.
League officials earlier this year negotiated a potential $1 billion settlement of lawsuits by retired players who say the league hid the risk of concussions. Some former players this month have objected to the settlement, saying it would not properly treat players yet to be diagnosed with CTE.
Reporting by Alex Dobuzinskis; Editing by Bill Trott


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Neuroscience research at HMRI is focused on discovering underlying causes, diagnostic tests, and improved treatments for human brain disorders. Study participants form the core of this research, supplemented with pre-clinical models to test new treatments.
Brain disorders affect over half of the American population and not knowing the underlying cause or cure for any of them presents an enormous challenge. New technologies, however, have potential to make substantial progress, and we embrace these in our work. The expertise of HMRI's neuroscientists combines detailed clinical assessments, brain physiology measures, analytical biochemistry, and the development of implantable devices to improve nervous system function. Neuroscientists and staff work closely with HMRI cardiovascular, stem cell, immunology, and imaging scientists, and also feed on stimulating interactions with other scientific groups within HMRI.
HMRI neuroscience groups include Molecular Neurology and Neural Engineering.
Neurosciences includes research in the following areas:
• Molecular Neurology
• Neural Engineering
Aging and Alzheimer's Disease Study
The purpose of this study is to investigate the causes of Alzheimer's disease, enabling earlier diagnosis and effective treatment. Using the latest advances in technology, three research disciplines have teamed up to achieve these goals: The Magnetic Resonance, Molecular Neurology, and Stem Cells Laboratories.
Study Participants:
We recruited 150 people with classifications of Alzheimer's disease, mild cognitive impairment, or without any cognitive impairment. We have found compelling evidence of altered lipids in brain-derived membranes in the spinal fluid from subjects with early disease, even before symptoms have started. We are now studying these and new participants to investigate how the chemistry and clinical condition change with time.
Participants are tested at HMRI over 1 to 2 months, broken up into several visits. Visits take 2 to 4 hours and include extensive clinical assessments, cognitive testing, body fluid collections for stem cell and biomarker research, and brain imaging using magnetic resonance. Assessments are repeated every 1 to 3 years, so that we can track changes that occur with time. Clinically relevant feedback from research is available for primary care physicians, and research progress feedback is provided to study participants at frequent HMRI presentations.
If you're interested in participating, please see our brochure: "Aging and Alzheimer's Study"
Migraine Research
We aim to better understand migraine, which disables about 30 million Americans. There are a number of variations in the pattern of migraine, but typical symptoms of severe headaches often with light, sound, and smell sensitivities, disturbed balance, usually with nausea or vomiting, are usually episodic. 3 million Americans suffer from chronic daily headache. Those that suffer migraine have a much higher frequency of many other related conditions: anxiety, depression, tremor, epilepsy, asthma, irritable bowel syndrome, painful bladder syndrome, fibromyalgia, and others. Our goal is to discover why so many disturbances of brain/nerve functions occur so commonly in those with migraine.
We have found that altered sodium regulation occurs within the nervous system and may cause migraine. We have also been studying many other changes in spinal fluid proteins and lipids during migraine. We continue to recruit study participants with migraine and controls for this HMRI research. We also collaborate with Dr. Robert P. Cowen of Stanford University School of Medicine in a study that is focused on New Daily Persistent Headache (NDPH).
If you're interested in participating, please see our brochure: "Migraine"
Mild Traumatic Brain Injury (Concussion) Project
Mild traumatic brain injuries, commonly called concussion, are the overwhelming majority of brain injuries suffered in recent American military engagements. Around 80% of military concussions are suffered in similar situations to those of civilian injuries, namely sports, road traffic, or domestic accidents. Severe head injury requires hospitalization, but concussion frequently goes undetected. The injury effect is not so obvious to the victim and is hard for observers, including physicians, to diagnose.
The most needed tools for managing patients with concussion include objective tests for diagnosis and prediction of recovery. Emergency room physicians of Huntington Memorial Hospital refer patients that they discharge with concussion, or those with minor non-head trauma as controls. These volunteers are studied using a combination of clinical, psychological, physiological, imaging, and blood measures. Research is repeated over the month after injury to discover tests that both diagnose acute concussion and that predict recovery. View Dr. Michael Harrington's bio.
Established in 1970, the program is multi-disciplinary (name the disciplines) with the overall goal of design, development and evaluation of implantable devices for functional electrical stimulation that can replace or augment impaired function of the nervous system.
The Huntington Helix was developed by the NEP with funding from the Neural Prosthesis Program of the National Institutes of Health. It was licensed to Cyberonics, Inc. and has been implanted onto the Vagus nerve of more than 75,000 persons with epilepsy. Vagus nerve therapy is approved in the U.S. for reducing the frequency of epileptic seizures in adults and adolescents with" partial onset seizures" which are resistant to antiepileptic medications.
With funding from the National Institutes of Health, we are developing devices that can activate the nerve cells in a person's brain or spinal cord in order to alleviate symptoms of neurological disorders. A major effort of the NEP is the development and testing of "penetrating " microelectrodes which are implanted into a patient's brain or spinal cord where they can activate nerve cells in a precise and well-controlled manner, and do so safely and effectively for many years. A major portion of this effort is directed towards developing a device that can restore hearing to persons with deafness who cannot benefit from hearing aids or cochlear implants. In other projects, we are collaborating with the Illinois Institute of Technology, and with Pixium Vision SA, to develop visual prostheses that may restore some vision to persons with blindness.
We are working with the Huntington Memorial Hospital's Sleep Center to develop a new method of treating obstructive sleep apnea. Our device uses biofeedback to cause the user to develop a new reflex that keeps their tongue forward in their mouth while they are asleep so that it will not obstruct their airway.
View Dr. Douglas McCreery's bio.


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- Please select a date to see the proper prices!
Description of the Accommodation
Rooms, services Guests looking for accommodation in Saint-Martin-de-Belleville are welcome to book 17 nicely furnished rooms at Chalet Hôtel Isatis Saint-Martin-de-Belleville. The bar is an ideal location for a personal meeting and a relaxing evening talk. Your valuables can be the safely secured in the safe. The exact scope of services offered by Chalet Hôtel Isatis Saint-Martin-de-Belleville (including those for an extra fee) is available on the information sheet below.
Payment Credit card guarantee or advance bank card payment may be required for the reservation, depending on the chosen room, date and price.
Arrival, opening hours The earliest arrival time is 15:00, the latest time to leave the rooms is 10:00. The personnel speaks French and English.
Chalet Hôtel Isatis Saint-Martin-de-Belleville rooms Rooms
- Please select a date to see the proper prices!
Accommodation services
Pet friendly, Bar, Elevator, Safe deposit box


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Separate names with a comma.
Discussion in 'Herman's Genres' started by Herman, Dec 16, 2013.
Anne Frank's house, Amsterdam
View attachment 82987
There are things hidden under this beach, and in the white hut on the left.
Any guesses ?
View attachment 82988
Hidden by clearbluesky44, on Flickr
(taken with a point and shoot, I'm afraid, so the picture quality isn't the best)
On the coast of the UK it could be anything. Wreck? Smuggler's contraband? I feel that I should know where that is but can't put my finger on it.
D :smile:
Sorry, not even close. Not smugglers contraband or buried treasure.
Is that the transatlantic cable hut?
Very good, yes it is.
It's Porthcurno Beach in West Cornwall, not that far from Lands End. It's where early submarine telegraph cables left mainland Britain and set off for the empire - India and Africa and beyond. Quite an amazing technological and logistical achievement in the late 1800s. The copper cables were/are buried under the beach and terminated in the white hut on the left of the picture.
I believe that modern fibre-optic communication cables still come ashore there,.
I took the picture from the Minack Theatre, which is perched on the cliffs above Porthcurno.
Of course it is!! I should have known, I spent many happy holidays in that area of Cornwall as a kid.


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FFA/Agriculture Program
Children at the Harbor have the opportunity to participate in the FFA Agriculture program. The home for the Harbor's agriculture program is a 4,000 square foot barn that was completed in 2013. Children at the Harbor are able to raise a variety of animals ranging from chickens and turkeys to hogs and steers.
Raising an animal teaches the children responibility and, if their animal sells at auction, satisfaction of hard work and savings in the bank.
There are many scientific studies that prove caring for an animal is therapeutic and provides unconditional love and affection.