text:
|Home | About | Journals | Submit | Contact Us | Français
Genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in the CHRNA5/A3/B4 gene cluster with heaviness of smoking. The nicotine metabolite ratio (NMR), a measure of the rate of nicotine metabolism, is associated with the number of cigarettes per day (CPD) and likelihood of cessation. We tested the potential interacting effects of these two risk factors on CPD.
Pretreatment data from three prior clinical trials were pooled for analysis. One thousand and thirty treatment seekers of European ancestry with genotype data for the CHRNA5/A3/B4 SNPs rs578776 and rs1051730 and complete data for NMR and CPD at pretreatment were included. Data for the third SNP, rs16969968, were available for 677 individuals. Linear regression models estimated the main and interacting effects of genotype and NMR on CPD.
We confirmed independent associations between the NMR and CPD as well as between the SNPs rs16969968 and rs1051730 and CPD. We did not detect a significant interaction between NMR and any of the SNPs examined.
This study demonstrates the additive and independent association of the NMR and SNPs in the CHRNA5/A3/B4 gene cluster with smoking rate in treatment-seeking smokers.
Heaviness of smoking is a heritable trait, with heritability estimates of approximately 50%–86% (Broms, Silventoinen, Madden, Heath, & Kaprio, 2006; Koopmans, Slutske, Heath, Neale, & Boomsma, 1999; Vink et al., 2004). Genome-wide association studies and candidate gene studies have found an association between heaviness of smoking and single-nucleotide polymorphisms (SNPs) found on chromosome region 15q25 in the α5-α3-β4 nicotinic receptor gene cluster (N. L. Saccone et al., 2009, 2010; Thorgeirsson et al., 2010). SNPs in this region are in strong linkage disequilibrium (LD), and Saccone et al. recently demonstrated at least two statistically distinct loci (marked by CHRNA5 rs16969968 and CHRNA3 rs578776, respectively) associated with smoking quantity (Saccone et al., 2010).
Another factor that has been shown to be associated with cigarettes per day (CPD) is the rate of nicotine metabolism as measured by the nicotine metabolite ratio (NMR; Benowitz, Pomerleau, Pomerleau, & Jacob, 2003; Johnstone et al., 2006). The NMR is the ratio of 3′-hydroxycotinine to cotinine and is a measure of the rate of nicotine clearance (Dempsey et al., 2004). Nicotine is metabolized to cotinine primarily by the liver enzyme CYP2A6. Cotinine is in turn metabolized to 3′-hydroxycotinine exclusively or nearly exclusively by the same enzyme. As a ratio of metabolite to parent drug, the NMR is a measure of enzymatic activity through that pathway (i.e., CYP2A6 activity). The activity of CYP2A6 is determined in part by genetics. The CYP2A6 gene is polymorphic, and various alleles are associated with reduced activity; however, known CYP2A6 genotypes account for only a modest proportion of the heritability of nicotine clearance rates (Swan et al., 2005). The NMR is significantly associated with CYP2A6 genotype (Malaiyandi et al., 2006) and has the additional advantage of reflecting environmental influences on CYP2A6 activity (Benowitz, Hukkanen, & Jacob, 2009). Therefore, the NMR may better reflect individual variation in nicotine metabolism as it affects smoking behavior (Ray, Tyndale, & Lerman, 2009).
Although both 15q25 genetic variants and NMR have been associated independently with CPD, to our knowledge, no studies have examined them in combination. Classic pharmacogenetic studies have shown that both variation in drug metabolism and drug targets are important to consider (Evans & Johnson, 2001). In this study, we examined potential interactions between the NMR and three of the SNPs in the CHRNA5-CHRNA3-CHRNB4 gene region that have been previously associated with CPD: CHRNA5 rs16969968, CHRNA5 rs578776, and CHRNA3 rs1051730 (Saccone et al., 2010; TAG Consortium, 2010; Thorgeirsson et al., 2010). Although rs16969968 and rs1051730 are in strong LD and may mark the same genetic locus, some studies have reported rs1051730 as a stronger signal (TAG Consortium, 2010; Thorgeirsson et al., 2010); we therefore decided to include both in our analysis.
While the precise functional consequences of SNPs in this region are unknown, the nonsynonymous SNP rs16969968 codes an amino acid change (aspartate to asparagine) at codon 398 of the CHRNA5 gene. This amino acid is highly conserved across species, and the presence of the A allele reduces the maximal receptor response to an agonist in vitro (Bierut et al., 2008), while the G allele of rs578776 has been associated with reduced mRNA levels in vivo (Wang et al., 2009); these are the same alleles associated with higher CPD in smokers. A recent paper by Jackson et al. (2010) showed that mice lacking the α5 receptor subunit were less sensitive to the initial effects of nicotine but continued to find nicotine rewarding at higher doses in a conditioned place-preference test. Taken together, these data suggest that the α5 subunit may be mediating receptor sensitivity and that a loss of function of the α5 subunit may decrease sensitivity to the adverse effects of nicotine at high doses. Thus, it is possible that smokers with the CHRNA5-A3 polymorphisms that decrease receptor response may smoke more because they experience fewer adverse effects. Moreover, these SNP effects on CPD may be more pronounced among faster metabolizers who exhibit more rapid nicotine clearance (i.e., a SNP by NMR interaction). Specifically, we expected that the faster metabolizers who also have the putative risk allele for the CHRNA5-A3 SNPs would smoke more CPD as compared to the other groups. Because our data were generated from three studies with different treatments and study designs, we examined the association of NMR and SNP genotype on pretreatment smoking rate only.
The study sample was composed of participants from three smoking cessation clinical trials: (a) open-label trial of nicotine patch versus nicotine nasal spray (n = 285; Lerman et al., 2004), (b) placebo-controlled trial of bupropion (n = 317; Collins et al., 2004), and (c) placebo-controlled trial of extended duration nicotine patch versus standard duration (n = 428; Schnoll et al., 2010). Analysis of pretreatment data was carried out on participants of European ancestry who had genotypes for the SNPs rs578776 and rs1051730 and complete baseline data for NMR and CPD. Within this subsample, 13 individuals had participated in more than one of the studies and were excluded, leaving a final sample of 1,030. Genotypes on the third SNP, rs16969968, were not collected in the bupropion trial, and 36 participants in the other two studies had missing data for the SNP, leaving 677 participants available for analyses involving rs16969968.
In the overall sample, 47.6% of participants were female, 40.9% were college graduates, and the mean age was 44.98 (SD = 11.01). At baseline, the mean CPD was 22.63 (SD = 9.32), mean nicotine dependence (FTND) score was 5.38 (SD = 2.20), and mean NMR was 0.416 (SD = 0.217).
Genotyping for SNPs rs16969968, rs578776, and rs1051730 was performed using the TaqMan SNP Genotyping Assays in a 384-well microplate format along with SNP-specific control samples (Applied Biosystems). The genotype distribution for the three SNPs was as follows: For rs16969968, 97 participants (14.3%) were of the A/A genotype, 325 (48.0%) were A/G, and 255 (37.7%) were G/G; for rs578776, 49 (4.8%) were A/A, 367 (35.6%) were A/G, and 614 (59.6%) were G/G; and for rs1051730, 152 (14.8%) were A/A, 491 (47.7%) were A/G, and 387 (37.6%) were G/G.
Pairwise LD (|D′| and r2) was determined using Haploview (Barrett, Fry, Maller, & Daly, 2005) from the subset of 677 participants who had data for all three SNPs. For rs16969968 and rs578776, |D′| = 1.0 and r2 = .182; for rs578776 and rs1051730, |D′| = 0.99 and r2 = .182; and for rs16969968 and rs1051730, |D′| = 0.98 and r2 = .957 (Supplementary Figure S1), which are consistent with previous studies (Bierut et al., 2008; N. L. Saccone et al., 2009). Genotype frequencies were in Hardy–Weinberg equilibrium.
NMR data were determined by liquid chromatography—tandem mass spectrometry (Dempsey et al., 2004) using blood samples collected at the pretreatment visit in each of the three studies. Participants were not given specific instructions regarding smoking behavior prior to collection; however, all participants reported smoking at least 10 CPD. The range of NMR values in this dataset was 0.01–2.08, consistent with previous studies (Johnstone et al., 2006; Swan et al., 2009). Previous studies at our center observed significant differences in smoking cessation between smokers in the lowest quartile of NMR and smokers in all other quartiles (Lerman et al., 2010; Schnoll et al., 2009). Based on those studies, we defined slow metabolizers as those in the lowest quartile (NMR < 0.27) and normal metabolizers as those in the top three quartiles (NMR > 0.27).
Chi-square tests and one-way ANOVAs were used to check for differences by genotype group on sex, education, and age. These variables did not differ by genotype on any of the three SNPs (p values > .05). Three linear regression models of CPD were then estimated. In each model, the predictors were sex, age, education (college graduate vs. other), NMR, and a set of two indicator variables denoting genotype on one of the three SNPs of interest. For each SNP, the reference category was the genotype with the lowest projected risk (i.e., associated with lower CPD) based on previous association studies (S. F. Saccone et al., 2007; Stevens et al., 2008). For rs16969968 and rs1051730, the indicator variables denoted genotypes of A/G and A/A, with G/G the reference category; for rs578776, the indicator variables denoted genotypes of A/G and G/G, with A/A the reference category. In each model, a set of two indicator variables representing the potential interaction of NMR by genotype was also included. All predictors were entered as a block after which the interaction terms were allowed to drop out if nonsignificant (p > .05). To obtain effect sizes for NMR within genotype, regressions of CPD on sex, age, education, and NMR were performed separately within each of the three genotype groups for each of the three SNPs.
Due to the high LD across SNPs, we used latent-class haplotypes to model CPD using the haplo.stats package for the statistical program R (Sinnwell & Schaid, 2009). Models included haplotype class and NMR as predictors of interest and sex, age, and education as covariates to control for error. Haplotype classes were restricted to those with ≥5% frequency, lumping the remainder into "other." We used the likelihood ratio to test the interaction between haplotype and NMR.
In all three linear regression models, sex, age, and education were significantly associated with CPD (p values < .01; Table 1). Both the NMR and the SNPs rs16969968 and rs1051730 were significant in the regression models of CPD, suggesting additive effects of faster nicotine metabolism and the risk alleles for these genotypes. The interaction terms were nonsignificant in all three models (p values > .40). The models of association of rs578776 and rs1051730 with CPD were repeated in the subsample of 677 participants with nonmissing data on rs16969968; the results were essentially unchanged. As shown in Figure 1a, in all cases, the putative risk allele was associated with higher smoking rates compared with the reference group. NMR accounted for an R2 change of .011 in the model including rs16969968 (.010 for GG, .026 for AG, and .006 for AA), a change of .006 in the model including rs578776 (.010 for AA, .003 for AG, and .011 for GG), and a change of .008 in the model including rs1051730 (.011 for GG, .012 for AG, and .001 for AA).
We also examined a dichotomous division of NMR into "slow metabolizers" (NMR < 0.27) versus "normal metabolizers" (NMR > 0.27; Schnoll et al., 2009); we observed a significant association between the NMR and CPD, but the interaction terms were nonsignificant (p values > .20; Figure 1b; Supplementary Table S1). In the exploratory haplotypic analysis, the risk haplotype (rs16969968 = A, rs578776 = G, and rs1051730 = A) was significantly associated with CPD; however, there were no significant interaction effects between any haplotype and NMR (p values > .30; Supplementary Table S2).
We hypothesized that slower nicotine metabolism, as measured by the NMR, would decrease the influence of genotypes for rs16969968, rs578776, and rs1051730 on smoking rate. We found significant independent and additive associations of NMR, rs16969968, and rs1051730 with CPD, but the interactions of the NMR with genotype on CPD were not significant. Contrary to previous studies, we did not observe a significant association of rs578776 with CPD in this sample of treatment seekers.
Although the precise functional consequences of SNPs at rs16969968, rs578776, and rs1051730 have not yet been established, all three SNPs have documented associations with heaviness of smoking in nontreatment-seeking smokers (Berrettini et al., 2008; TAG Consortium, 2010; Thorgeirsson et al., 2010). As demonstrated in prior published studies, rs16969968 has been associated with reduced receptor response to an agonist (Bierut et al., 2008) and rs578776 with reduced mRNA levels (Wang et al., 2009). It is also possible, due to the high LD across the CHRNA5-CHRNA3-CHRNB4 region, that these SNPs could serve as markers of yet undiscovered functional variants.
Contrary to our hypothesis, we did not observe an interaction between the NMR and CHRNA5-A3 SNPs on CPD. Positron emission tomography imaging has demonstrated that low levels of nicotine (i.e., smoking one cigarette after extended abstinence) can desensitize most of the available α4β2 nAChRs in a smoker's brain (Brody et al., 2006). Therefore, it is possible that the higher nicotine levels in the slower metabolizers might cause prolonged α4β2 desensitization, which in turn might minimize the importance of receptor sensitivity, explaining the lack of interaction between the NMR and CHRNA5-A3 variants. Another possible explanation may be that our study population is restricted to treatment-seeking smokers who report smoking at least 10 CPD. Because slower nicotine metabolism has been associated with smoking fewer CPD (Benowitz et al., 2003), by excluding individuals who smoke fewer than 10 CPD, our sample may not represent the full variation in CPD among slow metabolizers in the general smoking population.
In addition, differences in nicotine content between cigarette brands and individual differences in smoking topography may affect an individual's exposure to nicotine in ways that are not reflected in a measure of CPD (Pérez-Stable, Benowitz, & Marin, 1995). Slow nicotine metabolizers have been shown to take smaller cigarette puffs but not differ in the number of puffs taken compared with intermediate and normal metabolizers (Strasser, Malaiyandi, Hoffman, Tyndale, & Lerman, 2007; Strasser et al., in press). Cotinine, the primary metabolite of nicotine, has a half-life of 15–20 hr and may be a more precise measure of total nicotine exposure (Pérez-Stable et al., 1995). A recent investigation by Keskitalo et al. (2009) found an association between rs1051730 and cotinine level; the effect size of rs1051730 on cotinine level was 2.3 times greater than that on CPD in their study. An exploratory analysis of pretreatment cotinine level in our sample revealed a significant (p = .03) interaction between rs1051730 genotype and NMR (results not shown). The risk allele at rs1051730 (i.e., less-sensitive receptors) was associated with greater baseline cotinine levels in both the slow and normal metabolizers; however, this association was more pronounced among slow metabolizers [one-way analysis of variance, F(2 df) = 10.76, p = .00003] as compared with normal metabolizers [F(2 df) = 5.49, p = .004]. However,although rs1051730 is in tight LD with rs16969968 (which alters receptor function), no functional consequences have been noted with this SNP. Cotinine levels are dependent upon time from last cigarette and gradually rise throughout the day (Hukkanen, Jacob, & Benowitz, 2005), and the time of day of cotinine collection was not standardized among the participants in our sample. Additionally, since the NMR is calculated as the ratio of 3′-hydroxycotinine to cotinine, this may be a confounding factor in a statistical model that uses cotinine as an outcome. For these reasons, these cotinine results should be interpreted with caution.
In the recent meta-analysis by Saccone et al. (2010) a third genetic locus (marked by CHRNA5 rs588765) was found to be significantly associated with smoking rate after controlling for rs16969968. It is a limitation of our study that data for rs588765 were not collected for our sample. Another potential limitation is due to the high LD observed between rs16969968 and rs1051730; we might only be assessing two independent signals from the SNPs assessed in our sample. Our sample of 1,030 individuals gave us adequate power to detect an R2 change in an interactive model (SNP × NMR) of .006, which would correspond to effect sizes ranging from onefold to threefold larger than we observed. Thus, it is possible that we were unable to identify smaller interaction effects that may exist. Additionally, our sample is restricted to treatment-seeking smokers who reported smoking at least 10 CPD at pretreatment.
In conclusion, we confirm the association between rs16969968 and rs1051730 and the number of cigarettes smoked per day in a population of treatment-seeking smokers; this was also seen for NMR. The risk genotypes and fast nicotine metabolism appear to have additive effects on cigarettes smoked per day. To our knowledge, although multiple studies have established independent relationships between the NMR and CPD and between genotype at CHRNA5/CHRNA3/CHRNB4 and CPD, no other studies have looked at these two systems in combination. Understanding the interactions between pharmacodynamic and pharmacokinetic risk factors as they affect complex disorders such as nicotine addiction is important to advance our knowledge of nicotine dependence and develop better treatments for the future.
Supplementary Figure S1 and Tables S1and S2 can be found online at http://www.ntr.oxfordjournals.org
This work was supported by grants from the National Cancer Institute to CL (P50 CA143187 and U01 020830) and grants from the National Institute on Drug Abuse (DA 02277 to NB and U01 DA020830.)
Dr. CL has served as a consultant for and/or received research support from Pfizer, AstraZeneca, Novartis, GlaxoSmithKline, and Targacept. Dr. RFT owns shares and participates in Nicogen Research Inc., a company focused on novel smoking cessation treatment approaches. No Nicogen funds were used in this work, and no other Nicogen participants reviewed the manuscript. Dr. RFT has also consulted for Novartis. Dr. NB is a paid consultant for several pharmaceutical companies that market smoking cessation medications and has been a paid expert witness against tobacco companies in litigation related to nicotine addiction. Dr. RR has received a research grant from Pfizer. This research was not supported by industry funds. The other authors declare no conflicts of interest.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text:
The Kansas State football program and head coach Ron Prince announced the addition of three highly-rated junior college prospects Wednesday, including a pair of Rivals Top-100 performers.
Alesana Alesana (Malie, Western Samoa), Gary Chandler (Wichita, Kan.) and Eldridge Sims (Compton, Calif.) have each signed a National Letter of Intent (NLI) to play for the Wildcats, Prince said. The trio of December junior college graduates is slated to enroll at K-State in January and participate in spring drills.
Chandler, a defensive back from Coffeyville (Kan.) College and the No. 5 overall junior college prospect in the nation according to Rivals, originally signed with Kansas State in February of 2005 on the heels of a standout senior season at Wichita Heights High School.
Article Continues Below
While at Coffeyville, Chandler was considered the top player in the Jayhawk Conference. A two-time first team All-KJCCC selection and a 2006 NJCAA All-American, Chandler collected 134 tackles, three interceptions and forced three fumbles during his junior college career.
A key member of one of the top JuCo defensive units in the nation, Chandler helped lead the Red Ravens to a combined 16-7 record, two postseason bowl appearances and the 2005 Region VI title.
As a prep, Chandler gained over 1900 yards and scored 28 touchdowns as a running back during his senior year at Heights, earning 6A all-state as well as Kansas Top-11 honors from both the Topeka Capital-Journal and the Wichita Eagle.
A massive offensive lineman from the City College of San Francisco and a four-star prospect by Scout.com, Alesana grew up playing rugby in his native Western Samoa, but has flourished in the American game since arriving in the United State in 2004. A key member of one of the California Community College system's most potent offenses, Alesana earned first team all-state honors from the coaches association in 2006 and helped the Rams compile an 18-3 record during his two seasons in the City by the Bay.
While a starter at CCSF, Alesana anchored an offensive line that helped the Rams average over 430 yards and 35 points per game. CCSF also won back-to-back Nor Cal titles and was the 2006 state runner-up during his career.
Sims, a steady pass blocker from Compton College, is rated as the No. 96 junior college prospect in the country and is coming off a standout sophomore season. He possesses a lean frame and very quick feet for his size and could challenge for playing time right away.
Sims chose Kansas State over offers from Florida State, Iowa State and San Diego State.
Kansas State Mid-Year School Signees (3)
Name Pos Ht Wt *Elg. Hometown (Previous School)
Alesana Alesana OL 6-6 318 Jr. Malie, Western Samoa (CC of San Francisco)
Gary Chandler DB 6-0 180 Jr. Wichita, Kan. (Coffeyville [Kan.] College)
Eldridge Sims OL 6-6 288 Jr. Compton, Calif. (Compton College)
*Elg. – Expected year of athletic eligibility for 2007 football season
Alesana Alesana
Offensive Lineman
6-6, 318
Malie, Western Samoa (CC of San Francisco)
Quickly: A mammoth offensive lineman who played for one of the top offenses in the California Community College system… Earned four-stars from Scout.com, which rates him as one of the top tackles in the class of 2007… Received three-stars from Rivals.com… Has adjusted quickly to American football after growing up as a rugby player in Western Samoa.
City College of San Francisco: A 2006 first team California all-state selection by the coaches association… Helped lead CCSF to an 18-3 record and a pair of Nor Cal championships during his two seasons with the Rams… Helped CCSF to a 10-2 mark in 2006 and a berth in the state title game… Key component of an offensive unit that averaged 35.1 points and 453.6 yards per game during the 2006 regular season, while giving up less than 2.5 sacks per game… Overall, CCSF averaged 409 yards per game in 2006 and 440 yards per game in 2005… Paved the way for quarterback Zac Lee to finish third in the state in total offense (309.0 yards per game)… Joined the CCSF program in 2004 as a grayshirt.
High School: A native of Western Samoa, who grew up playing rugby… Attended Samoa College, a high school in Western Samoa… Graduated from high school in 1998.
Personal: Alesana Alesana was born Dec. 10, 1979, in Western Samoa… Hails from the village of Malie, which is located on the outskirts of nation's capital, Apia… Is undecided on a major.
Recruiting: Selected K-State over offers from Texas A&M, Texas Tech, Kentucky and Washington State.
Gary Chandler
Defensive Back
6-0, 180
Wichita, Kan. (Coffeyville CC)
Quickly: An extremely athletic defensive back who figures to push for immediate playing time… Considered to be one of the top junior college defensive backs in the country and the top player in the Kansas JuCo ranks… Rated as the No. 5 overall junior college prospect in the nation… Received four stars from both Rivals.com and Scout.com.
Coffeyville CC: A 2006 first team NJCAA All-American and two time first team All-Jayhawk Conference defensive back… Helped Coffeyville to a No. 13 final ranking, a 7-4 record and a berth in the Top of the Mountain Bowl… Recorded 70 total tackles during the regular season, including 29 unassisted stops, while forcing three fumbles… Part of a defensive unit that finished 2006 ranked 12th nationally in pass defense (103.3 ypg) and 16th in total defense (227.2 ypg)… The Red Ravens defense also finished first in the NJCAA Region VI rankings in scoring defense, allowing just 12.6 points per game… Helped lead Coffeyville to a No. 9 national ranking, a 9-3 record, a NJCAA Region VI title title and a berth in the Sea Island Bowl as a freshman in 2005… Collected 64 tackles, including two for losses… Also had three interceptions and forced a fumble as a freshman.
Wichita Heights HS: Helped Heights to a 10-1 record in 2004, its best ever... Rushed for 1,905 yards on 260 carries (7.3 ypc), with 28 touchdowns at running back... Gained over 200 yards in four straight games, with five 200-plus outings... May have had best offensive game of the season against Emporia with six touchdowns... Recorded 98 tackles, including 57 solo stops, with nine tackles for losses on defense... Named Class 6A all-state by the Wichita Eagle and Topeka Capital-Journal as a defensive back... Was also a member of both papers' 2004 top-11 all-class teams… Participated in the 2005 East-West Shrine game… Began his prep career at Wichita East before transferring to Heights after his junior season... Rushed for 1600 yards as a junior in 2003 at East... Earned all-league honors as a defensive back and was an honorable mention all-state selection... Played quarterback and defensive back as a freshman and sophomore at East... Coached by Rick Wheeler at Heights... Also lettered in basketball and played for East's state title team.
Personal: Gary Jermaine Chandler was born Oct. 31, 1986, in Wichita, Kan... Parents are Gary Chandler and Kathy Delt... Has two brothers, Brian (25) and Chris (11)... Comes from an athletic family as father Gary played at Tulsa, uncle, Vic, lettered as a defensive end at K-State from 1974-76 and uncle, Dewayne, was an All-Big Eight tight end at Kansas in 1992... Is undecided on a major.
Recruiting: Originally signed with the Wildcats out of high school as part of K-State's February 2005 class… Chose Kansas State over offers from Arkansas, Louisville, Iowa State and Missouri.
Eldridge Sims
Offensive Lineman
6-6, 288
Compton, Calif. (Compton College)
Quickly: A lean offensive line prospect with quick feet… Ranked as the No. 96 junior college player in the nation by Rivals.com… Listed as a three-star prospect by Rivals.com.
Compton College: Helped lead the Tartars to back-to-back 6-4 records… 2006 Compton offense averaged 217 yards per game, with 150 of those yards coming through the air… Helped freshman quarterback Kyle Parrish nearly reach the 1,500-yard mark in passing during the 2006 campaign while tallying seven TDs… Head coach was Angelo Jackson.
Recruiting: Selected K-State over offers from Florida State, San Diego State and Iowa State.

subset: commoncrawl


text:
- Product 445655
Sabian Legacy Heavy Ride Cymbal
- Write a Review
The Sabian HHX Legacy Heavy Ride Cymbal's stick articulation remains semi-dry and crisp over a cushion of warm tone, while the large bell offers a br...Click To Read More About This Product
We're sorry-this item is unavailable.
Find a similar product below or contact our experts for a recommendation of great alternatives. Call us at 800-449-9128.Customers Also Viewed:
Sabian HHX Legacy Heavy Ride is strong on definition.
The Sabian HHX Legacy Heavy Ride Cymbal's stick articulation remains semi-dry and crisp over a cushion of warm tone, while the large bell offers a brighter contrast.
Designed for drumming legend Dave Weckl, the Legacy heavy ride cymbal features a low-profile design and dual hammering -- traditional hand hammering with jumbo-sized HHX 'Tone Projector' over hammering -- creating a sound that is warm, dark, and very deep. Stick articulation is semi-dry and crisp over this cushion of warm tone. The large lathed but non-hammered bell offers a brighter contrast while blending with the overall sound. When played, the Legacy Heavy Ride responds with the stick articulation of a heavy model, but with the tonal response of a medium.
"The 'Heavy' name refers to this model being the heaviest within the Legacy range" said Sabian master product specialist Mark Love. "And though it has the crisp, clean stick articulation of a heavier cymbal, the weight of this model is in the medium range, so it is much more playable and musical than the name might suggest. As for the sound, Dave likes a clean, articulated stick response over a warm cushion of tone. Because his definition of darker is much deeper than most, designing that sound - crisp articulation over a low, deep and dark tonality - was extremely difficult. Extensive design work was necessary to make it happen, and our craftsmen employ various unique techniques in the process."
Concluded Weckl: "My time in the Vault revealed just how difficult it is to create many of the Legacy models. Between the idea and the actual cymbal there is an unbelievable amount of work. Like me, Mark Love and his team want to get the sounds as perfect as possible. Not only have they done an amazing job of doing this, their ability to be so consistent in making each cymbal sound and perform the way it should really impresses me."
The HHX Legacy Heavy Ride is individually hand crafted from Sabian B20 bronze. It is available exclusively in Natural Finish, and it quality-protected by a special Sabian Two-Year Warranty.
- Heavy
Reviewed by 4 customers
Comments about Sabian Legacy Heavy Ride Cymbal:
Not really what the name implies, this "heavy" ride is of a medium weight. So to anyone out there looking for that killer rock ride, you might want to look at some thing that actually is heavy. Of course thats not to say you couldn't play rock with it, but its true beauty really opens up when you're not slamming the crap out of it.It displays a good amount of stick definition, not stiff like a heavy ride but a little more than a conventional medium. I find that my model displays a little variation in texture across the bow, a little drier in a two inch strip three inches from the edge of the cymbal, the rest is a beautiful dark complex wash and doesn't overpower the stick definition until you start trying to keep up with louder volumes and you lose the definition you need for complex patterns at those volume levels. Unfortunately the the flip side is when you play too soft, its difficult evoke that wash without overwhelming the nature of low volume. The bell is great however: large, easy to strike and strong without being overpowering. Similar to the bell shape on the Paragon ride just lighter.While its not the most versatile platter in my sound palette, it is a gorgeous sounding instrument when used right. It is professionally crafted and therefore expensive, but you get what you pay for.I would recommend it as a main ride in an electric jazz or fusion setting where the volume stays within a medium to medium loud level.
Comments about Sabian Legacy Heavy Ride Cymbal:
really like this guy. more of a medium cymbal than heavy. very low in tone, with a fantastic trashy crash, well relatively quick decay. a bit washy when crash/riding it, but not too bad. the bell on mine isn't super strong, but that's fine by me. i love it because it's trashy without being thin/dainty. great, woody stick defintion when riding it, that's loud enough to cut through.
- Balanced Wash
- Bright Sound
- Nice Definition
- Responsive Feel
- Versatile
Best Uses
- Jazz Clubs
- Medium To Large Venues
- Recordings
- Small Venues
Comments about Sabian Legacy Heavy Ride Cymbal:
This ride is to me the perfect cross between a rock ride and a jazz ride, made able to be suitable for both styles, styles which Weckl's fusion projects mostly consist of. That being said, it can handle softer to louder music with cutting stick definition that's not too pingy and with a light underwash that sounds amazing. Also mine is crashable even being on the heavier side for these rides. The bell is defined and easy to hit, unlike my Sabian Artisan Medium Ride (20), though I also love it to death. And compared to the Artisan this ride cuts harder and still gives me that nice jazzy ride tone for my louder gigs. And much more versatility. Excellently designed and made.
Comments about Sabian Legacy Heavy Ride Cymbal:
I reviewed this cymbal as well as the 22" Vault Artisan Medium Ride at percussionreviews.com. The 22" Legacy Heavy Ride has a bit more ping, but a darker overall wash. It reminds me of the 1950's classic jazz albums. The craftsmanship on the Legacy is fantastic. I use it when playing along with my jazz LPs.


text:
Buckwheat : Gentlest Miniature Horse – Horse For Sale
March 7, 2009 by admin · Leave a Comment
Buckwheat : Gentlest Miniature Horse – Horse For Sale
Horse: Buckwheat
Location: Victor, West Virginia
Price: $350
Breed: Miniature
Color: Black
Gender: Stallion
Birth: 0/0/0
Markings: 1
Height: 9.0 hh
Weight: 0 lbs.
Reg. #: 0
Additional Comments:
Buck Wheat is a Stallion, Very Gentle. Super Great With Kids. However he is not Broke to ride, but he is halter broke. He has No health Problems. Gets along with other Horses Big and little. cialis buy on line He is probably the best, sweetest,and calmest miniature you'll ever meet. He is Black with a white mark on forehead. Please Call Or email. Can Email Pictures. Must sell.
Seller: horse_lover41 (Cydney Eades)
Phone: 304.658.9222
Email: email@example.com
Rover : Adopt Rover a Miniature Horse – Horse For Sale
February 23, 2009 by admin · Leave a Comment
Rover : Adopt Rover a Miniature Horse – Horse For Sale
Horse: Rover
Price: $3500
Breed: Unknown
Color: Unknown
Gender: Male
Birth: 1/12/1996
Markings: white .brown
Height: 1.3 hh
Weight: 0 lbs.
Reg. #: 2028695685
We picked up Cain the same day as April, he appears a bit younger, he could be April's son. Probably in cialis price compare his late 20′s. We are unable to physically handle him. He is very fearful of a human near him which makes him a danger for our volunteers.
Seller: marianajessy (mariana jesica)
Phone: 202.415.5468
Email: firstname.lastname@example.com
Sweetwaters Nicholas Newman : Miniature Horse, kid safe, visits schools. – Horse For Sale
February 17, 2009 by admin · Leave a Comment
Sweetwaters Nicholas Newman : Miniature Horse, kid safe, visits schools. – Horse For Sale
Horse: Sweetwaters Nicholas Newman
Location: Edmeston , NY
Price: $400
Breed: Miniature
Color: Black
Gender: Gelding is cialis over the counter
Birth: 5/3/1997
Markings: none
Height: 8.1 hh
Weight: 100 lbs.
Registry: yes
Reg. #: 0
Nick has been visiting nursing homes, schools and loves to be in parades. He has a great disposition, no biting or kicking and allows adults as well as children to do anything to him. He is completely black, lifts his feet, stands while being groomed, loads, bathes, clips and ties. He has no bad habits and would be great for someone with small children or grandchildren. Great 4H mascot. Crowds don't bother him either. Small children are safe sitting on his back and brushing him. Nick stands 29 inches tall and very well trained. Call or e-mail for more photos. firstname.lastname@example.com or 607-965-8438
Shipping Notes:
Shipping for Nick can be arranged
Seller: luckymranch (Michele Moratelli)
Phone: 607.965.8438
Email: firstname.lastname@example.com


text:
Burton Photography – The Farm, Asheville, NC…
We photographed a gorgeous fall wedding for a fellow professional photographer's daughter. The only thing more stunning than the incredible scenery was the beautiful bride.
I love the moments right before the ceremony when the bride and her father are preparing to walk down the aisle together and walk into a new stage of their relationship. It is often a tender, quiet time to reflect on what they mean to one another and the significance of having a special father/daughter relationship.
We were very honored to photography this wedding for Manny Cruz of Cruz Portrait. Design. His studio is located in Bradenton, Florida.
Burton Photography, The Farm – Asheville, NC WeddingOctober 5th, 2015
Burton Photography – The Farm, Asheville, NC…
166 Chapel Hills Rd - Boone - NC - 28607 828-266-9889


text: Lean Mass Asymmetry Influences Force and Power Asymmetry During Jumping in Collegiate AthletesBell, David R.1,2,3; Sanfilippo, Jennifer L.3; Binkley, Neil4; Heiderscheit, Bryan C.2,3Journal of Strength & Conditioning Research: April 2014 - Volume 28 - Issue 4 - p 884–891 doi: 10.1519/JSC.0000000000000367 Original Research Abstract Author Information Abstract: Bell, DR, Sanfilippo, JL, Binkley, N, and Heiderscheit, BC. Lean mass asymmetry influences force and power asymmetry during jumping in collegiate athletes. J Strength Cond Res 28(4): 884–891, 2014—The purpose of this investigation was to (a) examine how asymmetry in lower extremity lean mass influenced force and power asymmetry during jumping, (b) determine how power and force asymmetry affected jump height, and (c) report normative values in collegiate athletes. Force and power were assessed from each limb using bilateral force plates during a countermovement jump in 167 division 1 athletes (mass = 85.7 ± 20.3 kg, age = 20.0 ± 1.2 years; 103 men and 64 women). Lean mass of the pelvis, thigh, and shank was assessed using dual-energy x-ray absorptiometry. Percent asymmetry was calculated for lean mass at each region (pelvis, thigh, and shank) as well as force and power. Forward stepwise regressions were performed to determine the influence of lean mass asymmetry on force and power asymmetry. Thigh and shank lean mass asymmetry explained 20% of the variance in force asymmetry (R2 = 0.20, p < 0.001), whereas lean mass asymmetry of the pelvis, thigh, and shank explained 25% of the variance in power asymmetry (R2 = 0.25, p < 0.001). Jump height was compared across level of force and power asymmetry (p > 0.05) and greater than 10% asymmetry in power tended to decrease the performance (effect size >1.0). Ninety-five percent of this population (2.5th to 97.5th percentile) displayed force asymmetry between −11.8 and 16.8% and a power asymmetry between −9.9 and 11.5%. A small percentage (<4%) of these athletes displayed more than 15% asymmetry between limbs. These results demonstrate that lean mass asymmetry in the lower extremity is at least partially responsible for asymmetries in force and power. However, a large percentage remains unexplained by lean mass asymmetry. Departments of 1Kinesiology; 2Orthopedics and Rehabilitation; and 3Athletics, University of Wisconsin-Madison, Madison, Wisconsin; and 4University of Wisconsin Osteoporosis Clinical Center & Research Program, University of Wisconsin-Madison, Madison, Wisconsin Address correspondence to David R. Bell, firstname.lastname@example.com. Copyright © 2014 by the National Strength & Conditioning Association.


text:
GET THE MAGAZINE Subscribe now to start getting your magazines and music
JAZZIZ Magazine
Back Issues
August 31, 2012
The Fall 2012 Print Edition of JAZZIZ shown is en route to subscribers now. In the mean time, members can preview this issue by clicking on the magazine cover.
Click on feature photos to watch videos and album covers to hear the music. Enjoy!
© 2017 JAZZIZ Publishing. All Rights Reserved.
Your shopping cart is empty
Visit the shop
What's your favorite jazz?


text:
Published: Monday 27th April 2015 by The News Editor
Wasps are to launch a retail bond listed on the London Stock Exchange in a bid to become one of the richest rugby clubs in the world.
The new 6.5% secured bonds, which launch on Monday, could bring between £25million and £35million into the club, allowing Wasps to compete with the likes of French giants Toulouse.
"We expect to be in that position either at end of this season or next season," Wasps' chief executive David Armstrong told BBC Radio Five Live.
Last year, the club bought the 32,000-capacity Ricoh Arena in Coventry and moved north from their previous home in High Wycombe, and the move has brought significant financial benefits.
"We were previously the second-lowest revenue-generating club in Premiership rugby. We are now the second highest in Europe," Armstrong added.
"In terms of size of revenue, we will overtake Toulouse in the next few months. We are in a very strong position financially."
While most of their Premiership rivals rely on broadcast rights for the bulk of their income, Wasps are able to profit from a concert venue, casino, two restaurants and a hotel at the Ricoh.
"This is creating a new financial model in rugby," Armstrong added.
"The old model of either owning a purpose-built rugby stadium, or even being a tenant in somebody else's stadium, has now been superseded by what we've done."
Wasps, sixth in the Premiership, are already close to the salary cap, but the new finance raised by the bonds could allow the club to pursue the signing of a marquee player.
Published: Monday 27th April 2015 by The News Editor


text:
Sarah Palin Attempts to Insult Kathy Griffin
Matt | On 08, Mar 2011
First, she was a governor, then a vice-presidential candidate, and from there a FOX News contributor. Sarah Palin has now added comedienne, roaster, and wig-snatcher of all other comedians that do not agree with her.
The latest of Palin's outbursts are directed toward Bravo TV "My Life on the D-list" reality show star and comedienne Kathy Griffin. Over the weekend, Palin was asked her thoughts about Griffin in an interview. Here's was the former governor (i.e., Quitter-In-Chief) had to say:
"She's a 50 year-old, adult bully, really, is what she is, kind of a has been comedienne, and she can (make jokes about) me, I would just ask for respect to my children," said Palin.
I don't know what Kathy Griffin specials Sarah has been watching, but that woman is damn-near hilarious. No one is off limits and her dry humor is pretty funny. Palin is just pissed because Griffin's jokes about her were accurate. Griffin's response to the comment was to offer tickets to her upcoming Broadway show to "a fellow reality star," taking a jab at Palin and her stints in the media.
To be fair, Griffin has made Palin and her family the butt of many jokes over the past few months, as have many TV personalities. Griffin slayed Bristol Palin for all of the weight she gained on ABC's Dancing With The Stars. She also had some words for 16-year-old Willow Palin who thought it would be cool to use anti-gay slurs on her Facebook page.
Sarah Palin should continue to respond to criticism like this. It takes her further away from any hope of becoming president, which is a godsend for me. Responding to snide remarks like these only make Palin look as non-presidential as ever … (i.e., her normal self).
Thanks Sarah!


text:
Safety Blaster Horn - Seasense
The iBoats Experience
Boats for SaleBrowse thousands of constantly-updated listings and search by location, brand, and boat type See more...
AdviceConnect with our expansive community and tap into the knowledge base of the most dedicated boaters around. See more...
Shop ProductsBrowse and search for hundreds of thousands of boat parts, accessories, and supplies to suit your every need.
This item is found in the following Product Families
- Super loud and it floats!
- Mouth operated with a light blow
- Screams 120 dbs of sound that can be heard for over 1 mile
- Environmentally friendly
- Great for ball games, boating, PWC, SCUBA and safety
- Will never rust
- Meets U.S.C.G regulations
This product ships in 1 business day.
Add to Cart and enter your Postal Code to determine the shipping charges.
Most products and orders leave our warehouse in 1 business day. However, select items may take more processing time. Alaska and Hawaii orders please add 1 additional warehouse processing day.
Standard Shipping Policies


text:
Neyom FridayManhattan Beach, California, US
Writer, Mother, Wife
Neyom comes from the Cheyenne & Arapaho Tribe of Oklahoma and resides in Los Angeles, CA.
English (North American), English
North American
Middle Aged, Senior, Teen, Young Adult
Special Skills
Audiobooks, Business, Cartoons, Documentaries, Educational, Internet, Jingles, Movie Trailers, Music, Podcasting, Radio, Telephone, Television, Videogames
Payment Terms
Hire Neyom as a voice actor. Payment is made through Voices.com SurePay, an escrow service that guarantees your work is done to your satisfaction. Send payment securely by Visa, Mastercard or PayPal through Voices.com then download your files from the website.
Watch a video to see how to make a payment
Next Steps
To contact Neyom Friday about your project, request a quote today. We'll walk you through the process step-by-step. It's fast and easy.
This talent has not uploaded any demos yet.
Hire Neyom Friday as a voice actor. Working with Neyom Friday is fast and easy. We'll walk you through the process step-by-step.
Request a quote for your project today.


text: Seastar's R&D department has the ability to create 3D models to demonstrate how certain molecules will interact with surfaces. This capability allows us to quickly develop solutions for the semiconductor thin film deposition market. Below is an example of our modeling capabilities. This video shows the simulation of silicon precursors and catalyst interactions growing on a silicon oxide surface. If you would like to find out more about our ability to model solutions for your semiconductor thin film deposition issues, please contact our customer service department at email@example.com.


text:
3 Ways South Africa is Trying to Boost Financial Literacy
South Africa is a nation of debtors. In recent months, fresh figures from 2014 have come to light which reveal that, in the same year, South Africa's citizens borrowed more money than those of any other nation. Over this period we collectively owed R1.63 trillion to our creditors, with 86% of us taking advantage (or indeed disadvantage) of some form of credit from 2013-14.
It also appears that we are not responsible borrowers. While 12.8 million South Africans are in good standing with their creditors, over 21.5 million are not. 10.5 million have impaired credit records, while an even more shocking 11 million+ are considered to be "over indebted".
Financial ignorance
Perhaps this should come as no surprise in a nation where a recent survey conducted by Wonga.za revealed that just 43% of the 18,000 individuals polled knew what a credit report was. The survey also revealed more significant gaps in our national financial literacy. 77% of respondents stated that, when making use of credit products, they did not check for fees or interest rates – instead taking on debt blindly. Meanwhile, 32% admitted to saving no money whatsoever on a monthly basis. The full survey data is downloadable via this blog post.
Of course, the ability to save money does not rest solely on an individual's financial wherewithal. Indeed, in a country with one of the widest income inequalities in the world, it's incredibly difficult for those at the lower end of the pay divide to save at all – let alone regularly. Yet, with such high levels of personal debt and such shocking statistics coming to light via Wonga, it's clear that financial literacy is a factor in our personal financial health as a nation.
Government involvement
The Government is paying some attention to the dearth of financial acumen amongst the general population, but is it doing enough to help rectify the situation?
Back in 2014, National Treasury chief director of financial sector development, Ingrid Goodspeed, spoke to The Guardian, claiming that a lack of education in financial matters made it difficult for South Africans to assess financial products and make shrewd decisions about which to use and which to avoid. This, she claimed, led to many falling victim to financially harmful situations like pyramid schemes, predatory lending practices and astronomical penalty fees. The result? A population plagued by limited savings and high levels of debt.
So what is being done to tackle our financial literacy problem?
1) A tax on lenders
In 2012, the Treasury decided it was time that financial service providers started chipping in to help raise financial literacy in South Africa. From national banks to independent lenders, all financial service providers much now contribute 0.4% of their post-tax net profits towards financial education.
2) The National Consumer Financial Education Strategy
The tax on financial service providers was just one aspect of a wider National Consumer Financial Education Strategy which, also launched in 2012, is targeting 16-29 year old black Africans particularly to raise the level of financial literacy in the country. The strategy hopes to have fully integrated finance into the national curriculum by 2017.
3) NGOs
It's not just the Government working for the cause. A number of non-government initiatives have also been set up. Banking Association South Africa are funding Teach the Children to Save, while a sister project called Operation Hope aims to teach individuals "financial dignity", giving them the tools they need to manage their finances more successfully.
Is this enough? Will the Government's 2017 target for the national curriculum be met? Have your say in the comments section below.http://www.dailynewsz.com/3-ways-south-africa-is-trying-to-boost-financial-literacy/http://www.dailynewsz.com/wp-content/uploads/2016/12/financial-literacy.jpghttp://www.dailynewsz.com/wp-content/uploads/2016/12/financial-literacy-300x300.jpgBusinessEducationworld newsfinancial literacy,south africa


text:
We need a driven, reliable, motivated & enthusiastic Laborer with valid (full G) Drivers License who is willing to work hard to learn more to become a Skilled Flat-Roofing TradesMan (with more money, of course). If you pay attention and have great mechanical and technical abilities, it won't take you much time to start earning $30+/hr.
If you have skills that would be a bonus but (if you are motivated) we are willing to train you.
Starting wage: $19/hr
You must be a Reliable and Competent Worker to accept this position.
Any ROOFING, RENOVATION, CONSTRUCTION, or LADDER work experience is an asset to your qualifications. State if you have any safety training certificates. (Expired, past, present, and current.)
Candidates will also possess: — Flexible daily schedules between the hours of 8:00am and 6:00pm pending workloads and start times. — Reliable transportation to west London (Commissioners & Wharncliffe area) Monday-to-Friday. — Occasional Weekend work. — Clean cut, hard working and diligent to improve skills. — Career oriented and goal driven. Wage increases and further training offered at an accelerated pace within our company.
Please send us your resume. If you can't send it straight from this site, then simply email us and after we reply, you can send your resume in an attachment.
If you wanted to be a Flat Roofer, THIS is your opportunity. Flat roofing is the way to go!


text:
Anna Hadid, M.D.
Jabr Hadid, M.D.
Having a primary care physician is very important to your health --
particularly during flu season.
So it's good to know that Internal Medicine physicians, Anna
Hadid, M.D., and Jabr Hadid, M.D., are here for you and are currently offering Flu Shots. But, even if you don't take advantage of these shots and happen to get the flu, they can treat you, too.
They are now accepting new patients over 18 years of age and most insurance plans are accepted for treatment.
Services offered include the following and more:
• Cold and flu management
• Adult vaccines
• Urgent care
• Chronic care management
• Diabetes management
• Blood pressure management
• Physical exams
Offices located at
2860 Lincoln Way E.
Massillon, Ohio 44646
Members of the Medical Staff at Affinity Medical Center.
875 8th St NE
Massillon, OH 44646


text:
Airline Pilot Party Decor
Navy Blue & White Striped Tablecloths
Navy Blue, Red & White Tissue Paper Pom Poms
Navy Blue, Red & White Aeroplane Bunting
Cutlery & Serviettes in Plastic Packets
Plastic Trays
Red Alphabet Letters
Navy Blue & White Striped Paper Straws
"Arrivals", "Departure", "Terminal", "Baggage Claim" & "Gate" Signs
Pilot Hats
Airline Pilot Party Eats & Treats
Cloud Cookies
Aeroplane Sandwiches
Aeroplane Cookies
Blue Candyfloss "Clouds"
"In Flight Meals" Gourmet Sandwiches
Airline Pilot Picture Cupcakes
Blue & White Cloud Popcorn Boxes filled with Popcorn
Sweets in Apothecary Jars
"Landing Gear" Chocolate Doughnuts
Blue Jelly Bowls with Mini Marshmallow "Clouds"
Aeroplane Pizza Bites
Aeroplane Cheese Bites & Biscuits
Marshmallow "Clouds"
"In Flight Snacks"
Selection of Chocolates & Crisps
Meringues "Clouds"
Airline Pilot Party Drinks
"Jet Fuel" Apple Juice
Mineral Water Bottles
Blue Lemonade
Vanilla Milk Bottles
Airline Pilot Party Favours
Suitcase Boxes
How cute!
I love this blue wall at Fantasy Park in Chartwell, Johannesburg! :)
This cute little birthday boy LOVES Boeings!
We decorated the eats & treats table with a navy blue & white striped tablecloth, navy blue, red & white aeroplane bunting (which was one of my favourite elements), a globe, food labels, navy blue, red & white tissue paper pom poms, "Arrivals", "Departure", "Terminal", "Baggage Claim", "Food Court" & "Gate" signs, a pilot hat, wooden spoons and paper serviettes in plastic packets, plastic food serving trays and the birthday boy's name in red alphabet letters.
We served popcorn in blue & white cloud boxes, blue jelly bowls with mini marshmallow "clouds", aeroplane pizza bites, cheese bites and cookies (thank you to Fabulicious Cakes!), "In Flight Meal" gourmet sandwiches, vanilla cupcakes in red & white polka dot cupcake cups with personalized Boeing cupcake toppers (thank you to mommy Michele for the artwork!) and "Landing Gear" chocolate doughnuts.
To drink we served delicious vanilla milk in glass bottles with navy blue paper straws and apple juice in a "Fuel" can with navy blue paper cups.
The adults enjoyed some of our delicious Gourmet Snack Platters. :)


text:
Fracking is short for hydraulic fracturing. This is a type of drilling that uses cutting-edge technologies responsible for the surges in U.S. oil and the production of natural gas. It involves tapping shale and other rock formations by drilling more than a mile below the surface, then turning horizontal and going another thousand feet. A single site can amass numerous wells.
Once the well is drilled, small holes are made in the horizontal part of the pipe. A mixture, containing 90% water, 9.5% sand and .5% other additives is pumped through the pipe at high pressures to create fractures in the rock. The additives in the fracking fluid mixture help reduce friction, which also reduces the amount of pressure needed, reducing air emissions. The additives also prevent pipe corrosion, which helps protect the environment and boosts the well's efficiency.
Safe fracking is a huge reason why the U.S. is experiencing an energy revolution. It allows the country to tap into vast oil and natural gas reserves that were previously unavailable. Upwards of 95% of all natural gas wells that will be drilled in the next decade will require this hydraulic fracturing technology. This type of fracking is also being used to create new production in old wells.
Because of fracking, the International Energy Agency claims that this country could become the world's leading oil producer. The U.S. is already currently the leading producer of natural gas in the world. The EIA estimates that the gas production from the years 2012 to 2040 will increase 50%, with natural gas from fracking being the lead contributor.
Natural has is an alternative energy and also a natural form of energy. Natural gas can replace fossil fuel and reduce the amount of harmful emissions released into the earth's atmosphere. It is non-toxic and can do all the jobs fossil fuels can, without threatening the soil, water or groundwater.
Most of the natural gas that is consumed is produced in the U.S. Overseas exportation is growing rapidly. A push to produce more natural gas in the U.S. has occurred more recently. Most of the natural gas is formed by heat and pressure on organic material and forms over millions of years.
Natural gas production can be an engine in alternative energy and allow humans to leave less of a footprint on the earth's environment. Fracking can give Americans more opportunities for jobs, boosting the country's economy at the same time.


text:
480 X Natural Turquoise Bracelets & Earrings - Individual Package
Natural Turquoise Bracelets & Earrings HIGH RETAIL VALUE
The total estimated retail value over $ 12000
Made by Natural Turquoise Styles includes Chaco canyon styles, antique,
classic etc.
Each item pack with its individual package. Retail Ready
Please look at pictures for more information
Items Include
192 X Hand Made Bracelets ( 24 styles - 8 Piece Each Style )
288 X Earrings ( 24 styles - 12 Each Style )
Please View the additional pictures by clicking the "View all photos" tab.
For an explanation on the various condition codes used on Liquidation.com please Click Here


text:
Irritable Bowel Syndrome is a common disorder of the colon that is characterized by a combination of symptoms, including cramping, abdominal pain, bloating from gas buildup and abnormal bowel conditions (diarrhea, constipation or both).
It is so common, in fact, that one in five Americans has the disorder. Twice as many women as men suffer from it. Seventy percent of all patients with IBS never seek medical attention and don't need to. It's not an illness like diabetes or hypertension that must be treated. IBS won't kill you.
That said, it affects as many as 35 million people, some moderately and some so severely that it completely takes over their lives.
A short circuit Over the years, doctors have learned that IBS is caused by an abnormality in the body's brain-bowel function. Research suggests that people suffering from it have colons that are more sensitive to stress and certain kinds of food.
The enteric nervous system and the central nervous system interact in what is known as the brain-gut connection. The enteric nervous system regulates the body's digestive system, and the central nervous system regulates stimuli, such as pain. Basically, there is an interruption in this connection.
People with IBS are misinterpreting the body's signals and magnifying them. Their colons are not functioning properly and are hypersensitive to normal stimuli.
The colon, a muscular tube about six feet long, connects the small intestine with the rectum and anus. Its major function is to absorb water, nutrients and salts from partially digested food that enters from the small intestine. After absorption occurs, a combination of nerves, hormones and electrical activity causes the colon to contract and move the remaining matter (stool) along its way. The colon also stores waste until it is time for it to be eliminated by a bowel movement.
Regaining control For people with moderate to severe IBS, the first step to better health is seeking medical attention.
While stress is not a direct cause of the disorder, it usually triggers symptoms. IBS patients with major stress in their lives are encouraged to seek out relaxation therapies, such as hot baths, yoga, massage or biofeedback.
For the vast majority of people, all they need to do is see their physician for help. IBS is a very treatable condition. The majority of people with mild IBS can use over-the-counter diarrhea medications or adjust their diets to ease symptoms. Increasing fiber intake and cutting back on trigger foods are often the best management tools.
Different people may have different trigger foods, but chocolate, milk, caffeine, alcohol and spicy foods are frequent offenders.
Antidepressants such as Zoloft, Paxil or Prozac, given in lower doses than used for treating depression, are also helpful for many patients. For IBS sufferers whose main symptoms include constipation, the new drug Zelnorm is extremely effective.
Managing IBS IBS is managed with lifestyle and dietary changes as well as over-the-counter and prescription medications. The following are known to be associated with an onset or worsening of symptoms:
- Large meals - Animal or vegetable fats - Wheat, rye, barley, chocolate, milk products or alcohol
- Caffeinated drinks - Stress, conflict, worry or emotional upsets
Dr. Cy Huffman is the senior vice president of medical affairs and chief quality officer at Munroe Regional Medical Center.
One in five Americans has IBS
Irritable Bowel Syndrome is a common disorder of the colon that is characterized by a combination of symptoms, including cramping, abdominal pain, bloating from gas buildup and abnormal bowel conditions (diarrhea, constipation or both).


text: Shu Ouma Inori Yuzuriha Pages in category "Guilty Crown characters" The following 2 pages are in this category, out of 2 total. I Inori YuzurihaS Shu Ouma Retrieved from "http://genomevoidswordschangetheuniverse.wikia.com/wiki/Category:Guilty_Crown_characters" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.


text:
Another example of how cloud GIS may be used in local government projects comes from Mihai Iepure, Faculty of Geography, Babes-Bolyai University Cluj-Napoca. Mihai Iepure wrote a case study in which he describes his implementation of GIS technology with a goal to assist the process of modernization of local heating network.
Namely, District heating Maintenance and Upgrade, in charge of the supply of heating and hot water in a district in City of Cluj, as well as in other parts of Romania, faces serious challenges due to the fact that in the last decade more than 50,000 apartments have disconnected from the system and switched to micro-heating units.* In order to preserve the district heating infrastructure, it was important to make the system more efficient by improving its maintenance and monitoring, which was the one of potential uses of Mihai Iepure's project in the future and which could pave the way for modernization of district heating system. His main idea was conceived as a way to assist the citizens of Cluj-Napoca in managing their own district heating needs by helping them with an interactive overview of heating infrastructure.
Mihai Iepure – Faculty of Geography, Babes-Bolyai University Cluj-Napoca:
"If we were to look at the GIS implementation in local administration in Cluj-Napoca, the second largest city in Romania, surpassed only by the capital city, Bucharest, there is not much to see. The institutions are not very happy to invest money in something they do not believe in. They see only the financial part of the investment, but not the results and benefits this new technology brings. The same thing goes with the Autonomous Administration for District Heating (AADH). At the moment, AADH does not use any kind of GIS, even though large amounts of money have been invested in the development, modernization and keeping up-to-date the public heating network in Cluj-Napoca. Having this in mind, I thought why not create an application for everybody to use to ease somehow the "relationship" between the AADH, as provider of service, and the population, as recipient.
First step was to gather information about the district heating power plants, like the exact position (address, WGS84 and Stereo 70 coordinates), water temperatures, contact information in case of emergency, pipe types, isolation material used for the pipes and other types of data provided by the AADH. The second step was to contact a local cartography and GIS company, MicroMapper SRL. They provided the graphical database of the application. Working with the datasets was done in a local ArcGIS environment, and for the upload on the GIS Cloud platform, the GIS Cloud's Publisher for ArcMap extension was used. The extension was very helpful because the uploading process went very smooth, and most importantly, the feature symbology was not altered. The webmap was featured in a couple of articles in the online version of two local newspapers: http://goo.gl/8STlz5 and http://goo.gl/ZY5rmk , with more than 1,000 views."
You can see the results of Mihai Iepure's project, edited with the help of GIS Cloud's Map Editor here.
Mihai Iepure's project resulted in an interactive web map which was easy to access and navigate by any of the Cluj-Napoca's residents. Now they could easily find the data they needed by simply searching their building by street address in the application, zoom in and get info they needed. For example, if they had a failure of hot water or heating system they could find out which is the station they are connected to and know where to call.
This project has a potential to be further utilized for district heating monitoring and maintenance, because it could be used for an overview of infrastructure and technical parameters required for different types of operations – for example the number of blocks or flats assigned to a power plant, technical info such as working temperatures, pressures, fuel type, modernization date and also contact info in case of emergency.
With his project, Mihai Iepure highlighted the benefits of implementation and usage of cloud-based GIS technology, which are, in his own words:
- facilitating access to information of public interest for citizens or access to project's data to clients
- cloud based platforms support having a large number of simultaneous users in applications
- system implementation costs are relatively low
- the introduction, maintenance and updating of data is centralized and in real-time


text:
Florence Darlington Technical College film production
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Learn about Florence Darlington Technical College film production, and registering for elective seminars and discussion sections. As a student, your first stop should be the registrar's office, where you can pick up a free copy of both the academic calendar and course catalog, in order to find available credit classes that you may be interested in taking. In-person class registration has largely been replaced with online sign-up, and many schools offer mobile apps that streamline the course registration process. Finally, check with your major department for assistance with prerequisites, tuition payment deadlines, and Florence Darlington Technical College Film Making information. Please use the form above to request admissions info for Florence Darlington Technical College.
Becoming a professional film actor is a very difficult process. Improvisation allows movie actors true expressive freedom, since they themseleves don't know how the situation is going to turn out. In professional acting, improv is also used to cover up momentary lapses, so the audience isn't startled. The actor?s performance is mediated by particular performance signs including facial expression, emotion, and vocabulary.
Classical acting is an umbrella term for a philosophy of acting that integrates the expression of the body, voice, imagination, improvisation and script analysis. Method acting by comparison, is a range of techniques based on for training movie actors to achieve better characterizations of the characters they play. Part of the training includes actors memorizing lines and therefore being able to work without a movie script. Other acting classes may include mask work, improvisation, and showing emotion for the camera. Beyond consideration for Florence Darlington Technical College film production, you may think about Chattanooga State Community College SAT test dates for complementary electives to your primary course of study.
Student Services Technician
Maricopa County Community College District
Knowledge of the philosophy and principles of a Learning College. Working within a learning college environment, this position serves as first contact for..
4 days ago Educational Center Director
FLEX College Prep
FLEX COLLEGE PREP. Since that time, FLEX has expanded to include a multitude of other services, including academic and college admissions counseling.
1 day ago Academic Support Advisor
Hondros College
Hondros College of Nursing is seeking an Academic Support Advisor. Our enrollment is conveniently offered four times a year with no waitlists.
7 days ago Director of Admissions
University of Maryland University College
Director of Admissions. University of Maryland University College (UMUC) seeks a Director of Admissions within the Strategic Enrollment Management (SEM).
1 day ago Admissions Advisor
New York University
Experience working with college admissions. Management of admissions criteria, policies, and student assessment.
5 hours ago


text:
Mr. Chairman,
On behalf of the European Union I would like to express our sincere appreciation of the effective way in which you and your team have conducted this meeting.
This week has provided national experts a valuable opportunity to exchange views on the practical implementation of the ITI. It has helped to identify gaps as well as successes in the national implementation, and has also enabled networking of national experts in both formal and informal settings.
We commend in particular you and your team on the extensive preparations prior to the meeting, contributing significantly to the success of our deliberations.
Thank you Mr. Chairman.


text:
Pitch Product Ideas for Walmart "As Seen On TV" Shelves
March 6, 2018 @ 6:00 pm - 8:00 pm
Event Navigation
Do you have a great idea you think can sell in Walmart?
Carrie Jeske reviews product inventions for the "As Seen On TV" section of shelves. Full licensing options available with no patent required or distrbuiton partnership agreements for those with market ready goods.
Let's roll. Come meet in person and show me what you've got. I sign my own NDA, so just ask if that's important to you.
To find out more, see: http://
See group info at:
To submit product ideas: Email Carrie[@]willitlaunch.com
Put PRODUCT NAME in subject line and link to demo video in email body with your contact info.
To Purchase Carrie Jeske's book on Amazon in audio, paper or ebook click:
Let's Connect:
Co-Invent & Learn Our Process Via Live Video
Join the Inventing Workshop Online. www.InventingWorkshop.com A nonprofit I support. Use coupon code "Inventing" for 50% off.
Get "As Seen On TV" Licensing Help
Join My Product Scout Team
Earn finder's fees up to $100,000 per product by simply connecting me to the next winner.
- Date:
- March 6, 2018
- Time:
6:00 pm - 8:00 pm
- Carrie Jeske
- Phone:
- 816-255-4600
- Email:
- email@example.com


text:
Poll: Which story should I write after all my stories in-progress are complete? Vote Now!
Author has written 9 stories for Bleach, and Naruto.
Hey y'all!
I love IchiHitsu. IchiHitsu all the way!
Gender: Girl.
Fave anime: Bleach.
Fave character: Toshiro.
Fave pairing: ICHIHITSU! (Obviously)
My english is not the best, I know, but all my stories will be in english.
If anyone fails, I laugh at them. If I fail, I laugh at myself.
Life is like a train. You step aboard. You take the trip. And you step off at your end station.
Around The Table.
Summer Vacation.
Switching Boyfriends.
Love Chaos.
Twin Trouble.
Stories in-progress and complete, you can see down below:


text:
So What Else is a nonprofit organization that strengthens our community through innovative youth programming and service-learning enrichment in under-served communities. We do this by imparting experiences and knowledge that position our youth to make sound life choices and realize their full potential.
We exist in a tripod of service:
Help the Kids
We provide +40 weekly after school programs at +25 sites across the Baltimore-Washington metropolitan area
Help the Community
Throughout the year, So What Else connects +1,000 volunteers with +60 projects with local organizations
Help Kids Help the Community
So What Else ignites the spark of service in our youth, connecting them with opportunities to Pay it Forward in their own communities


text:
Everyone I meet lately is stressed out by something or the other. We have unnecessarily complicated our lives. The constant need to get ahead of everybody has kind of driven us to the point of insanity. Don't get me wrong, there is nothing wrong with being driven and working towards the things that you want. I personally find it inspirational. But many of us kind of lose sight of everything else that is equally important in this obsession of ours. Things like happiness, peace of mind, the people in your life and your passions among other things are essential too. Make time for all these things too and you'd notice the significant difference in your quality of life.
Here are a few things that you could do to lead a happier, slightly stress-free life;
Ignore the negative criticism
You're not perfect, so naturally you have room for improvement. Sometimes we fail to see the error of our ways or our shortcomings, and it helps to have someone else point them out to us. Be open to criticism, but only constructive criticism. Do not allow negativity to disrupt your mental piece. You will be surprised by the number of people who would criticize you just for the sake of it, with no intention whatsoever of helping you in anyway. You need to recognize these people and simply ignore their input. If it's not helping you, you need not fret over it.


text:
Search from over 10 Million Auto Parts
Select Your Vehicle:
- Fast Shipping
- 30-Day Return Policy
- Low Prices
2004-2006 Lexus RX330 Cornering Light - Action Crash LX2860102
Review Fitment Notes to Ensure Proper Fit
Product Description
The 2004-2006 Lexus RX330 Cornering Light is a lamp assembly that is placed at the driver's side of the vehicle at the rear. It features a red lens to optimize the lighting of the vehicle exterior, maximizing safety and visibility. The unit is manufactured and shipped as new and offers an inexpensive way to replace a faulty or failed light in the 2004-2006 Lexus RX330 series, while restoring the original appearance and safety.
Some of our Customer Reviews
Very Satisfied
Reviewer: Jason Taylor
they ship really fast. there was hardly any wait time. great to deal with. I will be back and refer them to other people.


text:
the Malvern Hills (just a part of the chain) on a brighter day than it is today
We're back here in the lee of the beautiful hills - I'm sitting in the cab of the motor-home as I type this, and hoping that my one-hour WiFi token will allow me to post what I write. It's been a really hectic two days (one on the final set-up day, and then today which is Day One of the Show).
A delightful spot in designer Deb's garden - I need to check her details and will put link to them when I am not against the clock for internet time
I will now try to post this, and if it works, will write a 'day one' report on my new gardening blog (and thankyou to those who have already posted a comment on that.)


text:
Reuters Staff
1 Min Read
June 5 (Reuters) - Canada Post Corp-
* PayPal and Canada Post announce integrated payment and shipping solution Source text for Eikon: Further company coverage:
All quotes delayed a minimum of 15 minutes. See here for a complete list of exchanges and delays.
© 2017 Reuters. All Rights Reserved.


text:
Reuters Staff
1 Min Read
Jan 6 (Reuters) - Syncom Healthcare Ltd :
* Seeks members' nod to appoint Ajay Shankarlal Bankda as MD and chairman Source text: (bit.ly/2jbkdB9) Further company coverage:
All quotes delayed a minimum of 15 minutes. See here for a complete list of exchanges and delays.
© 2017 Reuters. All Rights Reserved.


text:
September 19th, 2016
Legendary actor Bill Murray played an unusual role over the weekend—Brooklyn bartender. The performance took place in honor of the opening of his son's new bar.
"This is my firstborn son, Homer," Murray told the packed house at 21 Greenpoint, "And I am so happy for myself, and his brothers and sisters and mom, and all of you, that he has not continued in the family business. Instead, he has taken the joy of the family—to have a drink, and to have a meal, and to have friends together in one place—and made it his life's work."
The Ghostbusters star was generous with the tequila ("I've already done four shots," he said less than five minutes into his new gig) as he sang along to songs like Stevie Wonder's "Higher Ground," and The Rolling Stones' "Miss You."
The appearance coincides with the release of a new book called The Tao of Bill Murray: Real-Life Stories of Joy, Enlightenment, and Party Crashing. It's a collection of stories about Murray from people who've had run-ins with him over the years.


text:
Traveling Luck for Petes Ferry (historical), Louisiana, United States
Where is Petes Ferry (historical)?What's around Petes Ferry (historical)?
Wikipedia near Petes Ferry (historical)
Where to stay near Petes Ferry (historical)
The timezone in Petes Ferry (historical) is America/Rankin_Inlet
Sunrise at 07:08 and Sunset at 17:10. It's Dark
Latitude. 32.4633°, Longitude. -93.3542°
Weather near Petes Ferry (historical); Report from Barksdale Air Force Base, LA 37.9km away
Weather : mist
Temperature: 9°C / 48°F
Wind: 0km/h North
Cloud: Solid Overcast at 200ft
Weather : mist
Temperature: 9°C / 48°F
Wind: 0km/h North
Cloud: Solid Overcast at 200ft
Satellite map around Petes Ferry (historical)
Loading map of Petes Ferry (historical) and it's surroudings
Geographic features & Photographs around Petes Ferry (historical), in Louisiana, United States
- stream;
- a body of running water moving to a lower level in a channel on land.
- Cooley Creek (2.8km)
- Brushy Creek (2.9km)
- Dorcheat, Bayou (6.5km)
- Clarke Bayou (6.7km)
- Boone Creek (7.1km)
- Hurley Branch (7.4km)
- Tanyard Creek (7.4km)
- Prairie Bayou (7.5km)
- Parmers Creek (9.1km)
- Toulon Bayou (9.8km)
- Carter Creek (10.9km)
- church;
- a building for public Christian worship.
- Mount Ealm Church (2.7km)
- Union Church (4.9km)
- Saint Marks Church (5.3km)
- Saint Johns Church (6.5km)
- King Solomon Church (7.1km)
- New Zion Church (10.1km)
- Saint Marys Church (10.3km)
- Tillman Church (10.5km)
- Bistineau Church (10.9km)
- Mount Morgan Church (11km)
- island;
- a tract of land, smaller than a continent, surrounded by water at high water.
- Snake Island (2.8km)
- Nancys Island (3.5km)
- Sandy Island (4.1km)
- Crane Island (5.1km)
- Lake Crane Island (5.5km)
- Little Crane Island (5.5km)
- Birds Island (6.5km)
- Goat Island (6.9km)
- Plum Orchard Island (8.3km)
- populated place;
- a city, town, village, or other agglomeration of buildings where people live and work.
- Noles Landing (0.6km)
- Yellow Pine (4.1km)
- Port Boliver (5.5km)
- Buckhorn (historical) (6.1km)
- Plum Orchard Landing (7.5km)
- Martin Junction (10.4km)
- Local Feature;
- A Nearby feature worthy of being marked on a map..
- Petes Ferry (historical) (0km)
- Adams Church (historical) (8.1km)
- Carter Chapel (8.2km)
- Point Chapel (9.4km)
- Andrew Chapel (historical) (10.1km)
- Ogden Spur (historical) (10.1km)
Accommodation around Petes Ferry (historical)
- school;
- building(s) where instruction in one or more branches of knowledge takes place.
- Harkness School (historical) (6.8km)
- Adams School (historical) (8km)
- Jenkins School (10.1km)
- Heflin Elementary School (10.7km)
- cemetery;
- a burial place or ground.
- Union Cemetery (4.8km)
- Reeves Cemetery (9.8km)
- Bush Cemetery (9.8km)
- Andrew Cemetery (10km)
- dam;
- a barrier constructed across a stream to impound water.
- Shirley Willis Pond Dam (4.1km)
- John M Robinson Pond Dam (5.4km)
- lake;
- a large inland body of standing water.
- Crane Lake (6.1km)
- Tadpole Lake (7km)
- oilfield;
- an area containing a subterranean store of petroleum of economic value.
- Sibley Gas and Oil Field (9.3km)
- administrative division;
- an administrative division of a country, undifferentiated as to administrative level.
- cliff(s);
- a high, steep to perpendicular slope overlooking a waterbody or lower area.
- Pine Bluff (10km)
- building(s);
- a structure built for permanent use, as a house, factory, etc..
- mountain;
- an elevation standing high above the surrounding area with small summit area, steep slopes and local relief of 300m or more.
- Indian Mound (7.8km)
- cape;
- a land area, more prominent than a point, projecting into the sea and marking a notable change in coastal direction.
- Gusta Point (2.6km)
- park;
- an area, often of forested land, maintained as a place of beauty, or for recreation.
- Lake Bistineau State Park (4.2km)
Wikipedia entries close to
Petes Ferry (historical)
- Heflin, Louisiana city city o
- Doyline, Louisiana city city o
- Sibley, Louisiana city city o
- Dubberly, Louisiana city city o
- Dixie Inn, Louisiana city city o
- Haughton, Louisiana city city o
- Ringgold, Louisiana city city o
- Minden, Louisiana city city o
- Jamestown, Louisiana city city o
- Eastwood, Louisiana city city o
- Red Chute, Louisiana city city o
- Barksdale Air Force Base airport airport
- Castor, Louisiana city city o
- Gibsland, Louisiana city city o
- Mount Lebanon, Louisiana city city o
- Bossier City, Louisiana city city o
Airports close to Petes Ferry (historical)
Barksdale afb(BAD), Shreveport, Usa (37.9km)
Shreveport rgnl(SHV), Shreveport, Usa (57.4km)
South arkansas rgnl at goodwin fld(ELD), El dorado, Usa (126.4km)
Monroe rgnl(MLU), Monroe, Usa (160.1km)
Texarkana rgnl webb fld(TXK), Texarkana, Usa (160.7km)


text:
A History of Western Art
Category: E-Book
A History of Western Art
Frederick A. Praeger | 1968 | ISBN: 0500180865 | English | 362 pages | PDF | 47.5 MB
This deliberately concise history is something of a tour de force, intended to stimulate the expert as well as to guide the layman. Throughout, it is motivated by the author's belief in art as a vital activity and, therefore, as something that - in the words that open and close the book - "has not ceased to be produced." Not a bare factual outline, it concentrates on individual works of art, whether a Minoan statuette, a Gothic reliquary, or a Raphael portrait. What is told is, in effect, the story of Western man's creative energy constantly finding new ways to fill the world with non-natural objects. The author imposes no arbitrary pattern or simple explanation but, rather, emphasizes the novel element of surprise in every work of art that has often disconcerted people at first sight - long before nineteenth- and twentieth-century controversies about "modern" art. The result is a book that does justice to major styles and many artists over the whole course of Western art, and also communicates a sense of the authors own enjoyment in looking at works of art of every kind.
Buy Premium Account To Get Resumable Support & Max Speed
Links are Interchangeable - No Password


text:
Will travel 10 miles
$40 per hour.
0.0 0 ratings
I began playing lacrosse in middle school, and have played for more than ten years since. In high school, I earned all-league honors, and upon entering the University of Washington, I joined the men's club lacrosse team. I have coached at multiple GameBreakers lacrosse summer camps, teaching kids from ages 6-14 the great game of lacrosse! I'm Aaron, a recent graduate from the University of Washington with a bachelor's degree in Biology. I am currently applying to medical schools across the country and working as a medical scribe at Overlake Hospital. However, I have found that I have plenty of [more]
Will travel 10 miles
$30 per hour.
4.87 46 ratings
I have played lacrosse for 15 years. I began at a private middle school where I played against schools that feed into some of the top collegiate programs in the country. I then set many records as a goalie during my four years at Briar Woods High school, where many of my records remain intact. I then moved onto two years of collegiate club lacrosse in the Texas Women's Lacrosse League during my time at Texas A&M University, where I earned the state defensive MVP title. I also have volunteer experience coaching various age levels of lacrosse. [more]


text:
A study showed that baby teeth are a rich source of stem cells, which are like protocells that can be grown into multiple kinds of cells if needed.
That means that if later in life, a child needs replacement tissue for whatever reason, the stem cells from their baby teeth can be used to grow the needed tissue. Pretty amazing!
Potentially, the practice of storing baby teeth could save lives and treat a variety of ailments.
Most of us can remember that first little wiggle that let us know a change was coming, and then the weird absence of a tooth when it finally fell out.
In 2003, a study determined that baby teeth contain stem cells and that if preserved quickly after falling out, the stem cells can be stored for years and kept in case of later medical problems in life.
So if you thought getting a dollar for your tooth was cool, then getting the chance to grow any kind of tissue, from heart cells to brain cells, and repair damaged tissue is really cool.
But there's one catch: the baby teeth have to be kept fresh. Like anything, stem cells degrade and lose their potency over time.
So simply keeping your child's baby teeth in a box isn't going to cut it.
Instead, parents can use services like Store-A-Tooth to properly preserve their children's teeth.
The teeth are placed in a liquid nitrogen cryopreservation vault, where the stem cells will remain intact and usable for years.
If later in life, the child, who may be an adult at this point, needs their stem cells, the teeth are taken out of storage and shipped to their doctor.
It seems like all the cultures that had superstitions about the power of baby teeth were, in a strange way, actually onto something!
If you'd like to know more about storing baby teeth for your kids or grandkids, check out Store-A-Tooth for more information.
via littlethings.com


text:
I am so not a good beach mom. I know that. I try, but I just don't do it very well.
Don't get me wrong...I love the beach. Love it! When I can walk along the beach, right on the edge of the water. When I can pick up a shell or two that catch my eye. When I can sit on a chair with my toes in the sand and read a book or just enjoy watching the sea gulls and pelicans. I love the beach like that, along with a good ocean breeze.
I'm not a good beach mom though. I don't like to play out in the ocean. Can't stand thinking about what all else is in the water, living and non-living. Ick! I don't like to sit in the sand where the waves are coming in and get sand all in my bathing suit. Double ick! I don't build very good sand castles, and do I really need to ooh and aah over the 37th piece of a shell that looks like half of the other 36 that are already in the bucket? (The answer to that, of course, is YES!)
But for this beach trip, that's what the grandmother is for. Most of it, anyway. I can enjoy shells and walking with three sandy little girls along the beach. Then I can sit on the beach blanket and watch two little girls work diligently on sand castle after sand castle that keeps getting eaten by the waves, no matter how high they attempt to build the wall around it while the third little girl sits in the sand and plays with her grandmother. That I can do. Apply sunscreen? Sure. Hand out juice boxes and water bottles? I can do that too. Move the blanket and towels and cooler and myriad of flip flops when the tide starts coming in? Absolutely. Happy to do it.
Just don't make me get in the water or sit in the sand. I'm happy to watch everyone else be happy playing at the beach. Now...if I only had a book...


text:
Covers sudden and unforeseen mechanical or electrical breakdown of plant and machinery. The policy can be extended to cover consequential loss from interruption to the business following such breakdown.
Machinery Breakdown (material damage / business interruption)
March 24, 2011 By
Copyright © 2017 · Berkrey Insurance Consultants · Website Design · Bullie Graphics · Log in


text:
Golden Bay group launch world equal-gender Government petition and 'Walk into the Street and Wave'
Currently there are four men to every woman in Parliaments world-wide. It's time to change this.
Check out the petition Equal Gender Government here.
We are a group of people from Takaka, New Zealand promoting 50/50 male/female governments globally. We are a non-profit organisation being developed under the umbrella of the Golden Bay Work Centre Trust.
There are many issues surrounding the status of women in the world. Our focus is on the balance of government representation worldwide. Currently it stands at 81% men to 19% women – more than four men to every woman.
'Walk into the Street and Wave' 12.30pm Thursday 8th March 2012 is a positive and peaceful event that allows anybody to express their support for global gender equity – simply by standing on the pavement and waving to each other.
We are promoting the Wave Event by:
- Providing a link to Petition Online supporting the creation of gender equal government world wide. Equal Gender Government for New Zealand Sign up today.
- Advocating for referendums on creating "gender equal" governments.
- Seeking positive and constructive comments and essays to post on our web site.
- Providing a links page for more information on issues relating to gender equity.
- Lobbying governments and politicians.
- Providing a printable poster page to promote the Wave Event – Logo Posters & Flyers.
a WordPress rating system
a WordPress rating system
One Comment »
Congratulations to Happyzine, you come top of the google page.
'Walk into the Street and Wave' Equal Gender Government For New
Perhaps the greatest human rights issue of our time, we can
lead the world again.
Information, links and a place for news and viewsGD Star Rating
a WordPress rating systemGD Star Rating
a WordPress rating system


text:
Undergoing the visa quest in america can be quite a tumultuous experience, with a lot of paperwork and fascinating using the government bodies to get done. One important thing that have to be done is taking the Immigration Medical Evaluation - a obligatory and required part of the complete step ladder of your Immigration experience in america. immigration lawyer new jersey
- When you absolutely nothing in with a specific lawyer or.
- Several websites exist on the web that could give you excellent legal representative testimonials. There.
- Check out PROMINENT Legal representative Sites:.
Another important phase is the visa procedure by itself, and so as to do that, it usually is wise to accept the services of any very good immigration lawyer, or perhaps an immigration attorney.
Below are great tips that may certainly allow you to get a attorney who could be most suitable for your situation:
Who could be most
Examine Well known Attorney Sites:
Many websites are available online that may give you good attorney referrals. There are SOME well-known websites that may be viewed on the web, which give rankings of legal professionals pertaining to immigration and natural cards visas. There may be details as well on these sites, which is useful. So that you can find some useful specifics of law firms here. Leafing via peer scores is a terrific way to arrive at a conclusion concerning the legal professional as their professional services you may want to engage. immigration lawyer new jersey
Customer Evaluations:
After you absolutely no in with a particular attorney or legal professional business, try and Yahoo and google for more information and check for rankings. Customers accord reviews to those lawyers and they testimonials is needed you discovering how best they operate. Usually do not just matter the amount of evaluations and judge, but do take the time to study every overview very carefully. These thoughts issue, because they are full of insights regarding the legal professionals and their efficiency.
May be the web site totally skilled? Seek out customer critiques, and look out for links towards the honours or identification which has been received by them. Wonder why we are informing you this? All of these head to prove the lawyer of your business involved will continue to work hard at your situation, because they been employed hard at mastering their organization. So it makes sense to examine the websites meticulously before arriving at a choice.
- immigration lawyer new jersey.
- Is definitely the site totally expert? Hunt for consumer evaluations, and check out.
- Follow this advice that can surely allow you to find a legal representative who might.
- Several web sites are available on the internet which could provide you with excellent.


text:
Ridge Images is a premiere wedding photography company operating in Ottawa, and providing services in Ottawa, Montreal, Toronto, and internationally.
All images copyright Ridge Images. All rights reserved.
Ridge Images offers a wide range of products and services geared towards wedding photography. We do our best to ensure that your day is not only special, but captured in a way that you can relive all of your favourite moments in style and with the artistic flair you want for your home.
Alex started his photography career with a photo printing shop almost two decades ago. He fell in love with the beauty and memories that could be lived again and again in printed images and albums. He has taken this love of captured memories and applied it to photographing people and events ever since.


text:
Traveling is a notorious diet breaker, but it doesn't have to be. If you're fitness-minded, pack your own bag of snacks and then to one of these fitness-friendly travel destinations.
Aspen may be famous for its snow, but there's plenty of activity to be had year round. If you enjoy winter sports, definitely take advantage of the snowboarding skiing season, but if you prefer to spend time in the mountains without the snow, Aspen also has great summers. During the summer months, Aspen is filled with hiking trails and horseback riding. Take advantage of the luxurious pools at the resorts and you'll be sure to get a workout trying a new activity every day.
The Italian Coast may be known for its great food, but you'll be able to indulge after spending a day wandering up and down the hills that encircle the coastline or exploring the villages built into the hills.
Hawaii is a great vacation for fitness fans. Many of the resorts offer memorable and unique fitness classes, like yoga on the beach. Off the resort, discover trails that go through the tropical region, either on foot or on bike. Cool off by swimming in the clear blue ocean or try snorkeling, kayaking or any other number of watersports, like surfing.
Cruise ships don't have to mean just overindulging at the buffet. Take advantage of many cruise line's health conscious meals and spend time in the gym or the pool or even running laps on deck. Cruising can be a healthy and easy way to vacation without giving up on your diet and fitness goals.
Canyon Ranch Resort in the Arizona desert is all about health and wellness. Enjoy the resort's many fitness fueled activities, enjoy a healthy meal and try a spa treatment to soak away any remaining stress and muscle soreness.
Las Vegas may not seem like an epicenter for healthy living, but the quick weekend getaway offers state of the art gym equipment in many of the hotels. Wandering through the supersized casinos and out on the strip is also a good way to get in a workout.
[Image via Getty]


text:
Simply Calphalon Enamel 8 Inch Covered Omelette Pan – Link
Amazon has this highly rated Simply Calphalon pan right now at it's lowest ever of only $18.74!
- Black porcelain enamel exterior that is highly resistant to food odors, moisture and scratches. 2-Layer Nonstick interior for superior release and easy clean up.
- Domed tempered glass covers with silicone handle make it easy to monitor foods while they cook.
- Cast Stainless handle with Silicone & Brushed Stainless Steel Accents
- Oven safe up to 400°F. Hand Wash.


text: A DRL was on the cards for a long time. But I did not want to attach anything to the battery. So the plan was to attach the DRL to another power source. The DRL should look authentic and unique and not like just another Chinese DRL. Also wanted it to be cost effective; if the quality should be good then it cannot be cost effective. I wanted to do it myself rather than someone do a cheap work; also that way I can also manage any future repairs. I wanted daytime mode, nighttime mode and wanted to control the operation through switch; and it should be plug and play type electrical. Oh! Too many requirements and some of them conflicting too!! It was nearly a year of search and patience. Many times I had resigned to settle for some Chinese DRL on the net. But somehow I did not fall for it and kept the search going. Lots of bits and pieces of experiments did happen. Collectively the whole research ended up as below. A cool looking DRL, with all the requirements fulfilled. The whole experiment cost about Rs4000. The DRL material cost alone came to Rs2500. Both the cost does not include the time invested. In the next post, I will go through step by step setup of the whole DRL…..


text:
Learn how to play cello in Launceston! Select a cello teacher from the list below for further information about their cello lessons and contact details.
The Launceston Cello Teachers listed above are all members of Music Teachers Online. If you offer Cello Lessons in Launceston let visitors know - become a member!
Other related categories
- Accompaniment (1)
- Double Bass Lessons (1)
- Viola Lessons (1)
- Violin Lessons (9)