text:
|1. Dez. 1998
|25. Juni 1996
|16. Aug. 1995
|Auch ver�ffentlicht unter
|William F. Avrin, Peter V. Czipott, R. Kemp Massengill
|Urspr�nglich Bevollm�chtigter
|Proton Sciences Corp., Quantum Magnetics, Inc.
|Zitat exportieren
|BiBTeX, EndNote, RefMan
|Patentzitate (13), Nichtpatentzitate (30), Referenziert von (103), Klassifizierungen (25), Juristische Ereignisse (9)
|Externe Links: USPTO, USPTO-Zuordnung, Espacenet
The present invention is in the field of detection of foreign bodies within a host through non-destructive methods. More specifically, the present invention involves the detection of ferromagnetic bodies within a host material having a different magnetic susceptibility.
Industrial uses for metal detection systems include airport inspection for concealed weapons, mine detection and other military applications, as well as for the detection of traffic. Up to this time, metal detection systems have had little or no practical value for medical uses. This situation has changed substantially, however, now that Magnetic Resonance Imaging (MRI) scanning has become the premiere vehicle for noninvasive disease detection.
MRI scanning is used widely to evaluate diseases and injuries in the head. The sensitivity of MRI neurodiagnostic evaluation for brain tumors and other serious intracranial diseases is of such a high order that alternative older tests for such patients, such as X-rays and CAT scans, are rapidly becoming obsolete. In many parts of the United States, the MRI is now the preferred standard of care, and failure to prescribe MRI scanning can often be considered questionable. This revolutionary technology, however, is not without an inherent risk.
The particular risk addressed here, and in fact the most dangerous risk associated with MRI scanning, arises when ferrous metallic foreign objects reside in or near the eye or the brain of the patient. MRI systems use intense magnetic fields, typically one tesla (1T) or higher. When the magnetic field of the MRI system is applied, large forces are exerted on any ferromagnetic foreign body (FFB) within the magnetic field, and the ferromagnetic object tends to move. An elongated FFB can experience a strong torque, causing it to rotate. Such movement wreaks havoc on vital ocular or neurological structures. The most devastating effect of a ferrous metal object within the brain or the eye is the torque effect induced by the MRI magnetic field upon the ferrous object. Objects that are spherical do not rotate in the MRI magnetic field; however, most objects are not spherical. Therefore, most objects will tend to align with the magnetic field. This alignment is akin to a "propeller" effect, which can result in cutting through ocular or neurological tissues.
In most areas of the body, although damage can occur, the damage tends to be less extensive, because the body forms scar tissues and essentially "encapsulates" the ferrous metallic foreign object. This "encapsulation" does not occur to any significant degree within the eye or the brain. The two main areas of risk for MRI scanning, then, are the eye and the brain. The eye can have retained ferrous metallic foreign objects which are subjected to forces or torque which pull or rotate the object through the ocular tissues, which could cause a permanent loss of sight. Obviously, welders and machinists are at a particularly high risk. The clinical literature contains case studies of patients with previously unknown intraocular FFB's suffering blindness during or after an MRI scan. Motion of the FFB can cause effects such as vitreous hemorrhage, retinal damage, or even severing of the optic nerve. A similar problem exists within the brain, since a retained intracranial ferrous metallic foreign object can be moved through brain tissue. Neurologic deficit can be a consequence.
In other areas of the body, where the ferrous metallic foreign object becomes embedded in fibrous tissue, the risk of catastrophically damaging movement during the MRI procedure is minimal. However, forces on some aneurysm clips can be sufficient to cause either dislodging from a vessel or damaging displacement even without dislodging, at magnetic fields from 0.147 to 1.44 T. Clips are relatively large, measuring from 6 to 39 mm in length. Discomfort can also occur with heating of the encapsulated ferrous metallic foreign object. This heating occurs through induction caused by the radio frequency fields and pulsed magnetic field gradients used in MRI procedures. Excessive local heating is a risk for larger metallic objects, at least. Burning has been known to occur around pacemaker devices, for example. Pacemaker devices also present the potentially life-threatening hazard of malfunctioning during the performance of an MRI scan.
As shown above, FFB's in the body of a patient can cause significant problems during MRI scanning. The problems are especially important in the eye and brain, and there are some problems in other areas as well. The significance of the problems encountered is caused largely by the size of the magnet used. A typical MRI system generates a magnetic field strength between 10,000 Oersted (Oe) and 15,000 Oe, or 1 to 1.5 T. Often, the field is produced by a superconducting magnetic coil system. The cryogenic coils cannot be readily switched, so the patient is either inserted into the MRI machine with the magnetic field turned on, or the field is incrementally increased after the patient is positioned within the MRI machine. In either case, the changing magnetic field imposes a torque on any retained FFB, causing a rotational movement of the object. This torquing effect obviously occurs when the MRI scans the body region where the ferrous object is located, but it can also occur when other body regions are scanned. The magnetic field of the MRI system is very large, extending for a distance of several feet. Thus, for example, when the knee is scanned, a large magnetic field is applied not only to the knee, but also to the eye and brain. So, even during MRI scanning of the knee, torquing of an FFB in the eye can occur.
Damage can arise not only in conventional MRI units with magnetic field strengths of 1 T or higher, but also in units with field strengths as low as 0.35 T. Laboratory studies with freshly harvested animal or cadaver eyes have found that intraocular and intraorbital FFB's show the most significant movement during an MRI procedure using fields from 1 to 1.5 T in strength. These studies used implanted FFB's ranging in size from 1�2�0.5 mm to 1�9�9 mm to 5�5�7 mm. The strong consensus in the literature is that the risk of trauma from retained FFB's for metal workers is sufficient to withhold MRI, at least at field strengths greater than 0.35 T, in the absence of a screening test.
Attempts have been made to reduce the risk associated with retained ferrous metallic objects by constructing MRI machines with still lower magnetic fields, for instance, about 3000 Oe (0.3 T) or lower. These attempts have resulted in either a degradation of the final image or a prolonged exposure of the patient to the MRI field. Prolonged exposure can be particularly stressful for patients who suffer from claustrophobia, since many MRI systems enclose the patient. MRI systems operating at fields as low as 0.08 T and 0.06 T nearly eliminate the risk of ocular damage. However, the spatial resolution of images taken at such low fields is generally considered unacceptable. Therefore, such attempts at reducing the risk by reducing the magnetic field strengths have had suboptimal results.
Another option is to avoid the risk associated with retained ferrous objects by avoiding the performance of MRI procedures on a patient who is known to have such a foreign object in a high risk location. Avoidance of the risk in this manner is complicated by a frequent lack of vital information for the radiologist. The presence of ferrous metallic foreign objects in the eye, the orbit, the head, the chest, or other vital areas of the body, is a well known contraindication for MRI procedures. However, a patient often does not know that the foreign object is present, or the patient does not provide such information to the radiologist. Therefore, radiologists performing MRI scanning may be unaware that a patient has a retained ferrous metallic foreign object, with potentially catastrophic consequences. Ocular damage, with permanent visual loss, has occurred as a result of MRI scanning in such instances.
Risk determination with medical procedures is often difficult. Physicians must daily weigh the costs and risks of diagnostic procedures against the information gained, often with inadequate information as to the probability of an adverse reaction. In the case of MRI, a low-cost, low-risk screening procedure to detect FFBs would allow physicians to make this decision in an informed way, avoiding the risk of damage without depriving patients needlessly of a vital diagnostic modality.
Several procedures have been investigated for their applicability as pre-MRI screening procedures. In fact, the MRI procedure itself has been investigated extensively for its ability to provide images of intraorbital and intraocular foreign bodies. However, the MRI procedure itself is obviously unsuitable as a screening procedure except at very low magnetic fields. At such fields, the sensitivity of the MRI procedure is too low to detect many objects. In addition, since most existing MRI systems run at fixed magnetic fields, low-field screening with an MRI scan would have to be done with a separate MRI instrument. The cost of even an ultralow-field MRI instrument would be unacceptably high for routine screening.
X-ray radiography has shown mixed results in detecting foreign bodies near the eye. Some success has been experienced with larger objects, but some failures have also been recorded. Computed tomography (CT) is generally considered superior to simple radiography in detection of foreign bodies. Some studies have claimed highly reliable detection of bodies as small as 0.06 mm3, showing that CT scans can readily detect objects missed by radiography. However, some case studies have also shown failure of CT to detect even a significant steel object in the eye. Furthermore, the CT procedure is too expensive for routine screening. Both CT scans and simple X-ray radiography share another serious problem, in that they can differentiate between metallic and nonmetallic bodies, but not between ferromagnetic and non-ferromagnetic bodies. If these techniques were relied upon to withhold MRI procedures, this deficiency would lead to the needless denial of MRI procedures to some patients with retained non-ferromagnetic foreign bodies. If all patients having retained metallic objects were denied the application of MRI scanning, many of those patients would be needlessly deprived of a valuable diagnostic procedure. To base a clinical decision to perform or not to perform an MRI based on plain X-ray films showing a metallic foreign body is highly undesirable, as the X-ray does not answer vital questions regarding the ferrous composition of the retained metallic foreign object. This problem, together with the need to use ionizing radiation, and the occasional failure to detect significant objects, makes X-ray and CT techniques unsuitable for pre-MRI screening.
Ultrasound is another method for detecting foreign bodies in or near the eye. One study has found that ultrasound had a probability of detection, for all types of foreign body materials, of 93%, as compared to 40% for simple radiography. The detection rate rivals that of CT for intraocular foreign bodies, but falls short of CT for extraocular bodies in parts of the orbit. High-frequency ultrasound produces even clearer results. However, ultrasound procedures suffer the same deficiency as X-ray and CT procedures, in that they cannot distinguish ferromagnetic from non-ferromagnetic foreign bodies.
Passive magnetic detection, as used in magnetoencephalography (MEG), can detect the perturbation of the earth's magnetic field caused by a ferromagnetic object. Algorithms exist which allow localization and characterization of the object by measuring a complete set of magnetic field and gradient tensor components. However, the ultra-sensitive magnetometers used for MEG are exceedingly expensive. Furthermore, the static field perturbations caused by an FFB can be difficult to distinguish from background fields.
It would be advantageous to have a ferrous metal detection system designed to screen patients before the commencement of MRI scanning. With the rapid development of MRI scanning, such screening could reduce the morbidity and human suffering caused by MRI-induced movement of ferrous metallic foreign objects within or adjacent to vital organs.
In addition to the detection of retained ferrous metallic objects for pre-MRI screening, it would also be appropriate to provide a ferromagnetic detection capability to patients suffering from acute orbital and intraocular trauma. In many instances, nonferrous metallic foreign objects can be allowed to remain permanently within the orbit, minimizing iatrogenic surgical trauma. On the other hand, ferrous metallic foreign objects often require aggressive surgical removal, which is potentially more destructive than simply leaving a nonferrous metallic foreign object in place. A screening test which would minimize the surgical invasiveness required in a given clinical situation would be useful.
It is an object of the present invention to provide a method and apparatus for the detection of ferrous metallic objects retained within a selected region of a host. One type of host could be a patient being considered for MRI scanning. It is a further object of the present invention to provide a method and apparatus for determining the location and size of a retained ferrous metallic object within the body of a patient. It is a further object of the present invention to provide a method and apparatus for discriminating between ferrous and nonferrous retained metallic objects within the body of a patient. Finally, it is an object of the present invention to provide a method and apparatus for detection, location and characterization of a retained metallic object, which are noninvasive and safe, as well as economical and easy to use.
The present invention utilizes magnetic susceptibility measurement to accomplish the detection of retained ferrous metallic objects inside human tissue, as a means of screening patients prior to MRI and other medical procedures. It also can include the application of a combination of one or more magnetic measurement techniques, to enhance the accuracy, reliability, and economy of the screening process.
A field generating device is placed near the body region to be screened. The field generating device consists of one or more devices for generating a time-varying applied magnetic field. A sensor or array of sensors is also positioned adjacent to the body region to be screened. Signals from the sensors indicate the presence of any ferrous magnetic objects in the selected body region. Together, the field generating device and the sensor allow measurement of anomalies in the magnetic susceptibility of the body region being screened. Sensors can be stationary, or they can be movable to generate a magnetic susceptibility anomaly map over the body part being screened. The intensity and the time dependence or frequency dependence of the magnetic susceptibility anomaly can be interpreted rapidly by a computer processor to reveal the location and size of ferrous metallic objects retained within the screened body region.
Stationary magnetic sensors can measure an appropriate combination of magnetic field gradients, and subsequent processing of the sensor output signals with the well known Frahm-Wynn algorithm can locate and characterize the retained ferrous objects. Alternatively, a moving sensor or sensor array is mounted on a position-encoding fixture, and sensor and position encoder outputs are transmitted to a computer where they are analyzed to provide the desired information.
The novel features of this invention, as well as the invention itself, will be best understood from the attached drawings, taken along with the following description, in which similar reference characters refer to similar parts, and in which:
FIG. 1 is an expanded view of an excitation coil and sensor array as used in the present invention;
FIG. 2 is an elevation view of the excitation coil and sensor array of FIG. 1, as they would be used in screening a patient;
FIG. 3 is a plan view of a typical PC board, showing a typical placement of sensors; and
FIG. 4 is a side view of a patient, showing the invention in use.
The method of alternating current magnetic susceptibility measurement combines all the advantages of the prior art screening procedures described above, with none of their drawbacks. In this technique, an alternating magnetic field is applied to the selected region of the host, which is to be screened. Metallic bodies in the selected region will respond to the applied field, producing their own small alternating magnetic fields. These magnetic susceptibility anomalies are detectable using reasonably inexpensive sensors, and in contrast with passive magnetic measurements, the desired signals can be distinguished from background noise by synchronous detection. This is accomplished by measuring only the component of the responsive magnetic field that oscillates at the same frequency as the applied ac magnetic field.
Ferromagnetic metals can also be distinguished from non-ferromagnetic metals by the polarity and frequency dependence of the responsive magnetic signal. Ferromagnetic bodies have a paramagnetic susceptibility, in which the direction of the responsive magnetic moment is the same as the direction of the applied field. This susceptibility approaches a constant, non-zero value as the frequency of the applied field approaches zero. On the other hand, non-ferromagnetic metallic bodies display an eddy-current response, in which the direction of the responsive magnetic moment is opposite to the direction of the applied field. This non-ferromagnetic response approaches zero as the frequency of the applied field approaches zero. Therefore, a signal processor can discriminate between the two types of responses by making measurements at two or more frequencies and observing the change in the responsive magnetic moment.
Since this method will involve applying a magnetic field to the patient, this applied field is held sufficiently low to avoid causing injury. It has been found that an applied ac magnetic field of only 0.0001 to 0.01 T is sufficient for the practice of this method on a patient being considered for an MRI procedure. In the practice of this invention on other hosts, a different level of applied field might be necessary and sufficient. Fields of up to 0.01 T will not cause damage to the patient due to motion of FFBs. There is also little risk of inducing excessive electric fields, or excessive heating of metallic implants.
Since the applied magnetic field is very small, the responses from detected ferrous objects are also very small. A clinically useful tool must detect the ac magnetic response from the smallest ferromagnetic bodies that can produce trauma in the selected screening region of the patient, during MRI. A simple model can be used to estimate the size of the smallest signal which must be measured. In this model, the foreign body is a sphere whose magnetic susceptibility, normalized to the permeability of the surrounding medium, is much larger than one. If this spherical particle is exposed to a spatially uniform magnetic field, the magnetic field Bsig produced by the sphere itself is given by the relation
B.sub.sig ≈B.sub.app a.sup.3 /r.sup.3,
where Bapp is the applied field, a is the radius of the sphere, and r is the distance from the sphere to the magnetic sensor.
Placing the sensor close to the surface of the eye of the patient limits the distance from the sensor to any part of the orbit to a distance little greater than the diameter of the orbit. So, a reasonable value for r might be 5 cm. Studies estimating the minimum size of a particle which might be harmful suggest that a particle having a volume of 1 mm3 would be a reasonable minimum size. A 1 mm3 spherical particle would have a radius a of approximately 0.62 mm. A design value of 0.5 mm is selected, to provide a safety margin. With a=0.5 mm and r=5 cm, it follows that Bsig /Bapp =10-6.
The ability to detect these small signals depends on the magnitude of the applied field, the noise in the magnetic sensors, the noise from the magnetic environment, and the degree to which the effects of the applied field can be suppressed. As an example, an applied ac magnetic field of 10 oersteds (10-3 T) can easily be applied to a head-sized volume, without dissipating excessive amounts of power in the ac field coils, or causing injury to the patient. Fields of this magnitude, oscillating at a frequency between 10 and 100 Hz, are no greater in intensity or rate of change than the time-varying magnetic gradient fields used in MRI procedures.
With an applied field of 10-3 T, the magnitude of the responsive magnetic field from the model particle will be approximately 10-9 T. Therefore, where it will be used with an applied field of 0.001 T, the present invention requires a magnetic sensor which is inexpensive but still sensitive enough to detect this small magnetic signal, which will be received from the small foreign bodies which are of most interest. It is desirable to use a resistor having a sensitivity of at least 100 pT/Hz1/2 at 10 Hz, and preferably 10 pT/Hz1/2 at 10 Hz. The preferred sensor for this application is an improved magnetoresistive (MR) sensor recently developed by Eastman Kodak. Magnetoresistive sensors are a well developed, reliable technology used mainly in the recording heads of computer disk drives. Recent developments have enabled the manufacture of MR sensors with the requisite sensitivity, on the order of 10 pT/Hz1/2 at 10 Hz. The field produced by the model particle is at least ten times higher than the noise in the Kodak MR sensors, for a measurement bandwidth of one Hz. Therefore, even a few seconds of data-averaging time will push the sensor noise well below the signal strength of the particles of interest. A variety of other sensor types could also meet the requirements of the present invention in the appropriate applications, including fluxgate magnetometers and magnetotransistors.
In order to detect the small ac magnetic field from the retained foreign body, in the presence of the much larger applied ac field, it is necessary to suppress any fluctuations in the contribution that the applied field makes to the total measured field. Several strategies can be used, in various combinations, to suppress these applied-field fluctuations. First, a very stable applied field source is used, to ensure that the current in the applied-field coils is as constant as possible. Second, the applied ac magnetic field is created with a coil which is specially designed, so that the applied ac field has a first zone of nearly zero field strength at the location of the magnetic sensors, while having a second zone with a finite field strength in the selected region of the host being screened. Third, the difference is measured between the magnetic fields sensed by two or more sensors. The sensors are placed in symmetrical positions within the first zone of low field strength created by the applied-field coil, so that the ac field that they see is not only small, but nearly the same for both sensors. In this arrangement, the differential measurement between their signals tends to cancel out any effects of residual fluctuations of the applied field. Using these techniques, magnetic signals 108 times smaller than the applied ac magnetic field have been measured. This level of applied-field rejection is more than sufficient to detect the sizes of foreign bodies that are of interest.
In addition to rejection of noise caused by the applied ac magnetic field, there are two additional advantages to measuring the spatial differences, or gradients, of the magnetic field. First, it cancels out most of the magnetic noise from the environment, since the closely spaced sensors see approximately the same background fields. By making magnetic gradient measurements, we can easily suppress the ambient noise by a factor of 10 to 100, helping to ensure that the magnetic signature of a small ferromagnetic particle can be measured in the anticipated environments. For example, if the applied field were 10-4 T, the model particle considered above would produce a magnetic field of 10-10 T. Even in fairly noisy environments, the ambient noise is typically less than 10-9 T, at least at frequencies well removed from the harmonics of the AC power frequency, 60 Hz. Suppressing this noise by a factor of 100 would keep the environmental noise contribution an order of magnitude smaller than the signature of the model particle.
Second, measuring magnetic-field gradients enables a faster method of locating the source of a magnetic signal, and demonstrating where the source lies within the selected region of the host, such as the eye or the orbit of a patient. This method involves measurement of all five independent components of the ferrous object's magnetic field gradient tensor g.tbd.((∂Bi /∂Xj)) at a given point. Then, the Frahm-Wynn algorithm , well known to those skilled in the art, is used to determine the location, magnitude, and orientation of a magnetic dipole source having this field. This approach eliminates or reduces the need to map the responsive ac magnetic field at a plurality of locations in space. Use of the Frahm-Wynn algorithm is discussed below in more detail.
One way to locate the source of a magnetic field is to move the magnetic sensor, take several measurements at different positions, map out the magnetic field as a function of position, and then calculate a source location which best fits the magnetic-field map. One difficulty of this field mapping is the need to reposition the sensor many times, accurately measuring its position each time.
An alternative way to locate the magnetic source is to measure all five independent components of the magnetic gradient tensor at a single position in space. The location of the source is then determined from this single data point, by using an algorithm developed by Frahm and Wynn. The magnetic gradient tensor is represented by a collection of nine numbers, corresponding to the derivatives of each of the three components of the magnetic field with respect to each of the three spatial coordinates. However, through the fundamental laws of electromagnetism, the different spatial derivatives of the magnetic field can be related to each other, so that the magnetic gradient tensor can be expressed in terms of only five mathematically independent components.
The Frahm-Wynn algorithm assumes that the source is a magnetic dipole. This assumption is valid as long as the physical dimensions of the source are small compared with the distance between the source and the sensor. This condition is usually well satisfied in situations for which the present invention is intended. For example, in screening the orbit of a patient, the goal is to locate a piece of metal of perhaps a millimeter or less in its major dimension, which will be several centimeters away from the magnetic sensors. If the source is assumed to be a magnetic dipole, the dipole can be completely described in terms of six independent quantities. They are: three quantities for the orientation and magnitude of the magnetic moment (two angles to define the direction, and a third quantity to define the magnitude), and three quantities for the direction and distance of the source from the sensor (two angles and a linear measurement).
Frahm and Wynn demonstrated that, if the magnetic gradient tensor of the source is measured at a single point, that measurement can be used to calculate five of the six independent quantities which describe the dipole. Those five quantities are the orientation of the magnetic moment (two angles defining a direction in space), the direction from the source to the sensor (two angles defining a direction in space), and the product of the magnetic moment and the fourth power of the distance from the source to the sensor (the fifth independent quantity). Using any additional independent piece of related information, the magnetic moment and the distance from the source to the sensor can be determined, thus completely locating and characterizing the magnetic dipole source. This additional piece of information needed to solve for magnetic moment and distance can be obtained by measuring one of the three components of the magnetic field, as opposed to its derivatives with respect to position, or by repeating the magnetic gradient measurement at an additional location in space.
Since the Frahm-Wynn algorithm involves solving a non-linear set of equations, it does not provide a unique solution for the dipole location and size. Instead, it provides four possible solutions, the correct one plus three "ghost" solutions. In the present application, it may be possible to eliminate the ghost solutions which lie outside the screening region, such as a patient's head. Alternatively, the ghost solutions can be eliminated by measuring the magnetic gradient tensor at two locations in space, and applying the Frahm-Wynn algorithm to each set of measurements. The common solution found in both cases would then be the correct solution.
The magnetoresistive sensor which is the preferred sensor for use in the present invention reflects a change in the magnetic field as a change in the resistance of the sensing element. The resistance of the sensing element is read with the use of a Wheatstone bridge, as is well known in the art. Combinations of these sensors are used in the present invention to measure a magnetic gradient of a source.
In measuring the magnetic gradient tensor, a technique called the Three Sensor Gradiometer (TSG), developed by IBM Research can be used. The TSG gives superior background noise rejection and eliminates the need to measure a small differential signal, by directly subtracting the much larger background signals common to both sensors.
The simplest way to make a magnetic gradient measurement is to subtract the outputs of two sensors. However, this requires each sensor to have sufficient dynamic range to be capable of reading the full amplitude of the background noise in addition to the signal of interest. The TSG eliminates this problem by using a third reference sensor to eliminate the effect of the background field. Two primary sensors optimized for low noise are used to detect the magnetic gradient component of interest. The reference sensor, optimized for wide range, is operated in a magnetic feedback loop to monitor the magnetic background. The feedback loop monitors the signal of the reference sensor and supplies a current to a field-cancellation coil surrounding the reference sensor. The feedback loop adjusts the current to the coil to maintain the reference sensor in a constant field, as measured by the output of the sensor. At the same time, this same current is applied to identical field cancellation coils surrounding the primary sensors. This cancels the effect of the background field on the primary sensors, leaving the primary sensors to sense the residual magnetic gradient of the source. The difference between the fields sensed by the primary sensors is given by the magnetic gradient multiplied by the separation between the sensors, called the baseline.
The version of the TSG used in the present invention can have two layers of magnetic feedback loops, a primary loop and a secondary loop. The first, or primary, layer is the reference sensor feedback loop described above. The secondary layer consists of a separate secondary feedback loop for each primary sensor. Each secondary feedback loop monitors the output of one of the primary sensors and supplies a small additional current to the field cancellation coil for that sensor, as needed to cancel out the magnetic field entirely, at that sensor. The magnetic gradient of the source is then measured by electronically subtracting the outputs of the two secondary feedback loops.
The discussion above is stated in terms of the first-order gradiometer, which uses two primary sensors to measure the difference in magnetic field between two points in space. Higher-order gradiometers use larger numbers of sensors to measure the higher order spatial gradients of the field. For example, a second order gradiometer uses three primary sensors to measure the second derivative of the magnetic field with respect to position. The basic principles of the TSG apply to gradiometers of any order.
The magnetic gradiometer is used to cancel out some undesired magnetic background field, such as the applied ac magnetic field in the present invention, or magnetic noise from the environment, while still detecting the magnetic signal produced by a retained ferromagnetic foreign body. The two primary sensors are arranged so that they see the same background fields, but one primary sensor sees the desired signal more strongly than the other. In such a situation, subtracting the outputs of the two sensors will cancel out most of the background signal but will not cancel out the signal from the FFB.
A key parameter in designing the magnetic gradiometer is the length of the gradiometer baseline, or distance between the two primary sensors. To reject the background noise as well as possible, the two primary sensors need to be close together, in one sense. For example, to reject background noise, the separation of the two primary sensors should be small compared with the distance from the magnetic gradiometer to the sources of background noise. Similarly, to reject the effect of the applied ac field in the present invention, the primary sensors should be close together, as compared to the dimensions of the coil system that produces the applied ac field. However, if the primary sensors are placed too close together, as compared to the distance from the sensors to the signal source of interest, the two primary sensors will see the desired signal with approximately the same amplitude. In such a situation, subtracting the outputs of the two sensors will nearly cancel out the signal received from the FFB. The best compromise between seeing the desired signal and rejecting the background noise is typically achieved by choosing a gradiometer baseline which has approximately the same magnitude as the distance between the gradiometer and the signal source of interest. In the case where the present invention is used to screen the orbit of a patient for FFB's, this distance will be on the order of 5 cm.
The apparatus used in the present invention includes the following: (1) a set of excitation coils for applying the ac magnetic field to the screening region, (2) a set of optimally arranged magnetic sensors, and (3) equipment for using magnetic measurement signals from the sensors to detect and locate ferromagnetic objects, and for distinguishing the signals of the target objects from other interfering magnetic fields.
The excitation coils and magnetic sensors are arranged to reduce the interfering signal produced by the applied magnetic field. This requires that the applied field experienced by the primary magnetic sensors must be both as small as possible, and as nearly the same for all sensors as possible. Further, in order to ensure the detection of long, narrow ferromagnetic objects oriented in all possible directions, magnetic response measurements must be made in at least two locations relative to the region being screened.
A key problem solved by the present invention is detection of the small ac magnetic signal produced by a minute ferromagnetic foreign body, in the presence of an ac excitation field that may be several orders of magnitude larger than the signal of the FFB. FIG. 1 shows one arrangement of the excitation device 10 used in the apparatus of the present invention, to solve this problem. One of the strategies used is to configure the excitation device 10 so that the ac excitation field is nearly canceled out in a region within the device 10, within which the magnetic sensors will be placed. The excitation-field coil 12 is laid out on the surfaces of two printed-circuit (PC) boards 14, 16. The two PC boards 14, 16 are placed parallel to each other, with the magnetic sensors placed between the two PC boards 14, 16. Each PC board 14, 16 accommodates a multiplicity of parallel, evenly spaced current paths 18 traveling in one direction in the center region of the board, with return paths 20 along the outer edges of the board, approximating two spiral patterns. The spiral patterns on one PC board are connected in series so that, when a current is passed through them, the resulting electric current distribution approximates a uniform sheet of current flowing in the y direction in the Figure, over a substantial region near the center of the board. This region of the board is roughly defined by the area between the markers A--A and between the markers B--B in the figure. This current distribution produces a magnetic field which is nearly uniform over a region of space near the center of the board.
FIG. 2 illustrates that the region over which the uniform sheet of current exists is actually a six-sided region defined by the dashed line. This Figure also demonstrates one method of maximizing the size of this region of uniform current. The widths of the current paths 18 in the center of the board 14 can be increased, while the widths of the return paths 20 near the edge of the board 14 can be decreased. This enlarges the region covered by the uniform sheet of current to cover as much as possible of the PC board 14.
Returning to FIG. 1, it can be seen that two boards 14, 16 of this design are placed parallel to each other, with this relationship being shown in an expanded view in the Figure. In actuality, the PC boards 14, 16 are separated by a distance S which is small compared with the length and width of the central region of uniform current. The two PC boards 14, 16 are mounted so that the current paths 18 on one board are oriented parallel to the corresponding current paths 18 on the other board. The current paths on the two boards 14, 16 are then connected in series to an ac power supply 22, so that the current flows in the same direction on both boards, the y direction in the arrangement shown. The power supply 22 can be equipped with a control device, as is known in the art, to cause the field to be pulsed, to vary in frequency, or to have a waveform with multiple frequencies. These time variations in the applied field can assist in distinguishing the responsive field from the environmental background fields, by synchronization of the sensing circuitry with the power supply. In a region surrounding the centers of the two PC boards 14, 16, the magnetic field produced by this arrangement approximates that produced by a pair of parallel, uniform sheets of current flowing in the y direction. In the space between the centers of the two PC boards, the net magnetic field is nearly zero, since the contributions from the two current sheets approximately cancel each other. There is, however, a small residual magnetic field, since perfect field cancellation is prevented by the finite size of the regions of the current sheets, and the presence of the return paths 20 along the outer edges of the PC boards 14, 16. As will be discussed below, the magnetic sensors will be placed in a plane parallel to the PC boards 14, 16, with the plane of the sensors being located at the midpoint MP between the two PC boards 14, 16, so that the sensors will be in this near zero field.
FIG. 3 illustrates a typical PC board 14, with the region of the uniform current sheet shown by the dashed line. The magnetic sensors 24 are placed symmetrically with respect to the region of uniform current, so that the ac excitation field is nearly the same for each sensor 24. Further, since as mentioned above, the sensors 24 are placed in a plane midway between the PC boards 14, 16, the ac excitation field seen by each sensor 24 is not only uniform, but it is also near zero.
The magnetic fields at the locations of the sensors 24 must be spatially uniform, as well as small, so that a small error in the position of a sensor 24 does not interfere with the cancellation of the residual magnetic field when taking the magnetic gradient measurement. The effectiveness of the arrangement of the coil 12 depends in part on the dimensions of the two PC boards 14, 16, and the separation distance between the boards 14, 16. The ac fields at the locations of the sensors 24 are smallest and most nearly uniform if the sensors 24 are located as close as possible to the plane midway between the two current sheets, the separation between the current sheets is as small as possible compared with their length and width, and the length and width of the current sheets is as large as possible compared with the distance between sensors 24.
Each of these key dimensions is affected by other considerations. First, as discussed above, the length of the gradiometer baseline must be comparable to the distance from the sensors 24 to the source of the magnetic susceptibility anomaly. In the case where the invention is used to screen the orbit of the eye of a patient, this is the distance from the primary sensors to the most distant point in the orbit of the eye. The current sheets must be as long and wide as possible compared with this baseline, while the PC boards 14, 16 must be small enough that they can be centered at a point next to the patient's eye without the edges of the PC boards 14, 16 interfering with other parts of the patient's body, such as the shoulders. The separation between the current sheets must be large enough to accommodate the physical size of the magnetic sensors 24.
Further, the separation must be large enough to eliminate the "graininess" of the applied field which results from the electric current distribution pattern on the PC boards 14, 16. To approximate a uniform sheet of current, current is passed through a set of parallel traces 18 on each PC board 14, 16. Since there must be some finite separation between the traces, the resulting electric current distribution is not completely uniform, but instead has a periodic variation in the direction transverse to the traces 18, the x direction in FIGS. 1 and 2. The resulting magnetic field has a corresponding periodic variation, which is most pronounced immediately adjacent to the traces 18, and which decays with increasing distance from the current sheets. Because of this spatial variation, the magnetic fields in the region between the two current sheets are not completely canceled out. In addition, since this spatial variation occurs on a fine scale, relatively small errors in the position of a primary sensor 24 can cause significant changes in the amount of ac applied field seen by that sensor 24.
In designing the excitation device 10 for a given application, a goal must be set for the degree to which the background signal due to the ac applied field must be suppressed by the field cancellation coils and the magnetic gradient measurements. The magnetic sensors 24 are then placed far enough from each current sheet so that the periodically varying component of the ac field, or "graininess", is smaller than the acceptable residual fields. This limit on the separation of the sensors 24 from the current sheets then determines how close together the two printed-circuit boards 14, 16 can be placed.
For example, a reasonable goal for ocular screening would be to suppress the applied fields so that the ac signal seen by the primary sensors is roughly a factor of 102 or 103 less than that corresponding to the ac field amplitude actually applied to the eye. The "graininess" or spatial variation of the fields near the parallel traces 18 has a complex mathematical form. However, the dominant contribution has an exponential decay in the direction perpendicular to the current sheet, and a sinusoidal variation in the direction transverse to the traces 18. That is, the "graininess" of the field can be expressed roughly by the relation: ##EQU1## where δB is the varying component of the magnetic field, B0 is the spatially averaged value of the magnetic field, Δx is the separation between the traces 18, l is the period of the pattern of traces 18, z is the perpendicular distance from the current sheet, and x is the position coordinate in the direction transverse to the traces 18. In a typical case, l might be 2.5 mm, and Δx might be 0.25 mm. The magnitude of these dimensions may be dictated by the degree of precision with which the PC boards can be manufactured. If it is desired to have δB/B0 less than 1%, then, z, the distance from the magnetic sensors 24 to the current sheets, must be greater than 1.83 mm.
As mentioned above, the magnetic sensors 24 are placed between the two PC boards 14, 16, in the region of nearly zero applied magnetic field. To minimize measurement errors due to the residual applied field, the excitation coils 12 are laid out in a symmetrical way, and the magnetic sensors 24 are placed strategically to exploit this symmetry. More specifically, the current paths 18 and return paths 20 on each PC board 14, 16 are split into two spiral-like coils, arranged symmetrically about the y axis which runs down the center of the PC board. Consequently, the magnetic field produced by each PC board 14, 16 is symmetrical with respect to reflection through the y axis. The spiral coils 12 are also shaped so that the magnetic field is nearly symmetrical with respect to the x axis which lies in the center of the PC board in the direction perpendicular to the y axis. Four magnetic sensors 24 can be used, with the sensors 24 located at the four corners of a square, symmetrically disposed with respect to the x and y axes. With this arrangement, the applied field is not only small, but approximately the same for all the sensors 24. The sensor 24 at one corner is used as the reference sensor in a Three-Sensor Gradiometer, while the three other sensors 24 are used as primary sensors. The sensors 24 are connected to the appropriate TSG circuitry 30, where differences in the outputs of the three primary sensors are processed to measure gradients of the magnetic field of the ferromagnetic foreign body. The output 32 of the TSG circuitry 30 is connected to a computer processor 34.
In the case where the sensor 24 at each corner is a three-axis magnetometer, measuring all three components of the magnetic field, the outputs of this circuitry yield all five components of the magnetic gradient tensor. The gradient outputs can then be processed using the Frahm-Wynn algorithm, as is well known in the art, to locate and characterize the FFB.
The arrangement described above uses a single set of excitation coils 12 to make magnetic response measurements with the applied magnetic field oriented in one direction. Making a single measurement with such a "single coil" instrument may not detect a long, slender piece of ferromagnetic material whose long axis is perpendicular to the applied magnetic field. As an example, assume an excitation coil 12 having current flow in the y direction, and assume that the applied magnetic field at the location of the FFB is oriented, for instance, parallel to the x axis. If the FFB is long and slender, and if its long axis is oriented orthogonal to the x direction, the resultant field from the FFB may not be great enough to be detected by the sensors 24.
A more versatile apparatus results from using two excitation coils 12 in a "double coil" instrument, to produce magnetic fields oriented in two orthogonal directions. A first excitation coil 12 has the same design as shown in FIG. 1 or FIG. 2, including traces 18, 20 on two parallel PC boards 14, 16 to approximate the effect of two parallel, uniform sheets of current flowing in the y direction. A second excitation coil 12 is identical in design to the first coil 12, and the second coil 12 is accommodated on the surfaces of the same two PC boards 14, 16, but it is oriented at right angles to the first excitation coil 12. This second excitation coil 12 approximates the effect of two parallel, uniform sheets of current flowing, for example, in the x direction.
The two excitation coils 12 are comprised of two independent sets of traces which are accommodated on the PC boards 14, 16, using standard multilayer technology with an insulating layer between the two sets of traces. During magnetic response measurements, the two excitation coils 12 are supplied with ac power which is phase shifted by 90 degrees, so that the net magnetic field rotates continuously in the x-y plane, the plane parallel to the surfaces of the PC boards 14, 16. Changes in the responsive magnetic field produced by the FFB are measured as a function of this revolving applied magnetic field. This will detect the presence of any FFB having a significant dimension in the x-y plane.
By way of example, as shown in FIG. 4, the "double coil" apparatus can be used to detect FFB's in the eye of a patient. The PC boards 14, 16 containing the double excitation coils 12 are positioned approximately parallel to the forehead of the patient P, with the magnetic sensors 24 placed midway between the PC boards 14, 16. The entire instrument is placed as close as possible to the eye. Only two of the four sensors 24 are seen in this view. An applied magnetic field 26 is created by the second excitation coil 12 discussed above, in the PC boards 14, 16. The second excitation coil 12, which would create the magnetic field 26 shown in this view, is the excitation coil which has its current flow in the x direction, perpendicular to the page toward the viewer. A responsive magnetic field 28 is shown, resulting from the response of the FFB to the applied ac magnetic field 26.
A similarly shaped applied ac magnetic field (not shown) would be oriented orthogonally to the field 26. This additional applied magnetic field would be created by the first excitation coil 12 discussed above, which has current flowing in the y direction. The additional applied field would cause an additional responsive field (not shown) around the FFB. In this position of the instrument, the two orthogonal excitation coils produce an applied magnetic field which lies roughly parallel to the forehead. As the two excitation coils 12 are energized with a 90 degree phase angle, this applied field will rotate about the z axis. The sensors 24 will detect changes in the responsive magnetic fields around ferrous objects which respond to the applied magnetic fields in this plane. The signals from the sensors 24 will be processed as described above to measure the magnetic gradient of the FFB.
As mentioned above, long, slender objects with their long axes perpendicular to the plane of the applied field may not be detected. Such objects can be detected, however, regardless of orientation, by making measurements at two different positions of the "double coil" instrument. For example, with the instrument orientation shown in FIG. 4, the applied magnetic fields from both of the excitation coils would be essentially perpendicular to the z axis, in the area of the patient's eye. A long, slender object in the eye, with its axis essentially parallel to the z axis, might not be detected, since the axis of the FFB would be essentially perpendicular to the applied magnetic fields from both of the excitation coils. Therefore, to detect ferromagnetic bodies in the eye, measurements are made with two orientations of the sensing instrument. To detect such objects, a second measurement is made with the double excitation coils 12 oriented roughly parallel to the side of the face, with the magnetic sensors 24 again as close as possible to the eye. In this position, the magnetic field has a substantial component which would be parallel to the z axis, and parallel to the axis of the FFB. this magnetic-field component will produce a maximum magnetic signature for long, narrow objects oriented essentially parallel to the z axis.
While the particular invention as herein shown and disclosed in detail is fully capable of obtaining the objects and providing the advantages hereinbefore stated, it is to be understood that this disclosure is merely illustrative of the presently preferred embodiments of the invention and that no limitations are intended other than as described in the appended claims.
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|Mednovus, Inc.
|Ferromagnetic threat detection method apparatus
|25. Juni 2008
|20. Nov. 2008
|Frederick Dean Fluck
|Metal Detection System and Method
|17. Dez. 2009
|24. Juni 2010
|Intercept Logic, Inc.
|DC magnetic field interceptor apparatus and method
|1. Aug. 2006
|23. Sept. 2010
|Kotter Dale K
|Circuitry, systems and methods for detecting magnetic fields
|15. Aug. 2007
|18. Nov. 2010
|Dinesh Verma
|Ophthalmic diagnostic apparatus
|28. Sept. 2011
|19. Jan. 2012
|Jentek Sensors, Inc.
|Material Property Estimation Using Inverse Interpolation
|1. Aug. 2012
|11. Febr. 2014
|C. R. Bard, Inc.
|Ultrasound probe head
|1. Aug. 2012
|17. M�rz 2015
|C. R. Bard, Inc.
|Cap for an ultrasound probe
|24. Jan. 2014
|19. Apr. 2016
|C. R. Bard, Inc.
|Ultrasound probe head
|8. M�rz 2004
|14. Sept. 2005
|Siemens Aktiengesellschaft
|Apparatus for non-destructive detection of deep defects in electric conducting materials
|26. M�rz 2002
|3. Okt. 2002
|Quantum Magnetics, Inc.
|Simplified water-bag technique for magnetic susceptibility measurements on the human body and other specimens
|10. M�rz 2003
|5. Aug. 2004
|Keith A Kopp
|Mri protector
|23. Febr. 2005
|15. Sept. 2005
|Siemens Aktiengesellschaft
|Device for detecting defects which are deep and close to the surface in electrically conductive materials in a non-destructive manner
|23. Febr. 2005
|29. M�rz 2007
|Gabriel Daalmans
|Device for detecting defects which are deep and close to the surface in electrically conductive materials in a non-destructive manner
|11. Juli 2007
|7. Febr. 2008
|Battelle Energy Alliance, Llc
|Circuitry, systems and methods for detecting magnetic fields
|11. Juli 2007
|2. Mai 2008
|Battelle Energy Alliance Llc
|Circuitry, systems and methods for detecting magnetic fields
|600/407, 324/67, 324/235
|Internationale Klassifikation
|Europ�ische Klassifikation
|25. Juni 1996
Owner name: SAFESCAN MEDICAL IMAGING, CALIFORNIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:MASSENGILL, R. KEMP;REEL/FRAME:008089/0474
Effective date: 19960615
Owner name: QUANTUM MAGNETICS, INC., CALIFORNIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:AVRIN, WILLIAM R.;CZIPOTT, PETER V.;REEL/FRAME:008089/0481
Effective date: 19960618
|14. Juli 1998
Owner name: PROTON SCIENCES CORP., CALIFORNIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:SAFESCAN MEDICAL IMAGING;REEL/FRAME:009330/0879
Effective date: 19980522
|11. Jan. 2002
Owner name: MEDNOVUS, INC., CALIFORNIA
Free format text: CHANGE OF NAME;ASSIGNOR:PROTON SCIENCES CORPORATION;REEL/FRAME:012463/0050
Effective date: 20000112
|31. Mai 2002
|Fee payment
Year of fee payment: 4
|18. Juni 2002
|Maintenance fee reminder mailed
|1. Juni 2006
|Fee payment
Year of fee payment: 8
|5. Juli 2010
|Maintenance fee reminder mailed
|1. Dez. 2010
|Lapse for failure to pay maintenance fees
|18. Jan. 2011
|Expired due to failure to pay maintenance fee
Effective date: 20101201


text:
For style and prospects
Price: €775,000
Where: Busherstown House, Moneygall, Co Offaly
Details: Castellated period house and coach house on 10 acres
The Rudds, a well-known family in the Irish food and horse circles, are selling their Busherstown House in the midlands. As well as its appeal as a grand family home, it also has considerable potential for a leisure or tourist business.
The castellated house itself has nine bedrooms, four reception rooms and four bathrooms. In all, there are as many as 11 rooms at ground level, including storage rooms.
The sitting room, drawing room and formal dining room come with original marble fireplaces and decorative ceiling plasterwork. A big country kitchen with an oil-fired Aga is located next to the diningroom and has a number of storage rooms within easy reach.
Upstairs, most of the seven bedrooms are of manorial proportions, with two en suite bathrooms and two further family bathrooms.
Attractively renovated, the coach house has three-bedrooms, two bathrooms, an open-plan livingroom and a kitchen.
A building known as a studio extends to 167sq m and its catering kitchen and large downstairs room have potential for hospitality or promotional events.
Busherstown's asking price has been almost halved from €1.5m to €775,000.
Outside features include a walled garden, courtyard, a tree-lined avenue, two grass paddocks and stabling.
Located on the Tipperary-Offaly border, it is close to the M7 almost half way between Dublin and Limerick.
The agents are Knight Frank 01 6623255
Irish Independent

subset: commoncrawl


text:
As I am naval reservist in Edmonton, I am often asked, "Why does Edmonton have a navy?" Edmonton is landlocked; a navy needs water, these people plead. The answer that I always give is that Canada has a navy, and Edmonton is part of Canada.
There are twenty-four cities across Canada that have Naval Reserve Divisions, and Edmonton, a city of over a million people, is included in this list. Canada is a maritime nation, encompassed by three oceans, and has the longest coastline in the world.
Because most of the world's population lives near the ocean, their lives and livelihoods are impacted by events on the ocean. Ninety percent of world trade involves the sea, and Canada has major ports that facilitate the import and export of Canadian goods. The naval needs of Canada are vast and cannot all be met by B.C. and the Atlantic provinces.
Peter T. Haydon, as reported in the Canadian Naval Review, makes an unapologetic case in support of naval investment. The points below are heavy for the layperson, but are poignant and sharp:
- Despite its fiscal problems, Canada is an economic and moral leader, and as such, Canada has an obligation to help maintain order in the world.
- That obligation requires, if not demands, that Canada share the burden of maintaining order in the world, including the use of force when necessary.
- Idealistic notions of trying to share the burden through peacekeeping and the provision of aid are as delusional as they are ineffective in the initial phase of crisis management.
- No one can predict where or when the next crisis will occur or what impact it will have on world security; anyone who thinks they can is either a fool or a charlatan.
- The uncertainty of the world order today requires that states maintain versatile, combat-capable, and rapidly deployable military forces. As we should have learned from the Syrian War, crises must be contained before they can spread.
- Thanks to their inherent mobility and flexibility, navies and other sea-based forces will nearly always be the first responders to global crises.
- In many cases, a submarine can be the first vessel on scene to act as eyes and ears for the main force.
At the time of this writing, H.M.C.S. Vancouver is off the coast of New Zealand, providing humanitarian relief in the aftermath of an earthquake. Recently, Canadian ships also provided aid to Haiti. But ships are also a show of force, and they are uniquely able to travel around the world without overtly threatening other countries, as they traverse in international waters. It is, in general, not as easy to amass ground forces adjacent to a belligerent country as it is to manoeuvre and deploy a maritime task force.
With our international partners, Canadian ships help to keep the Strait of Hormuz open. We provide drug interdiction in the Persian Gulf and Caribbean Sea. We police off the coast of Somalia and in other troubled waters. We do all this while flying the Canadian flag, and Canadians should be proud of the effort that their sailors put into world security and maintaining world order.
Edmonton has a Navy because Edmontonians want to proudly serve in the Royal Canadian Navy, and we should be proud of the Canadians who step up to this duty. I personally know many Edmontonian reservists who have participated in many military exercises around the world, including the current NATO-led Operation REASSURANCE, which is putting pressure on Russian aggression, in defence of Ukraine.
Furthermore, if I may, our current Minister of National Defence is a former reservist.
It is a nice characteristic of most reservists that they work day-to-day civilians jobs but then choose to do more.
The money isn't awesome, although it is good, but the satisfaction is invaluable. Serving one's country is a touchstone to patriotism. It is not for everyone, but it is a great outlet for many.
As a final plug for promoting the importance reservists, when we work alongside Regular Force members, we sometimes breath fresh air (new eyes and ears) into entrenched military environments and work spaces. Ultimately, we want the best for our whole military and the integration of reservists into the offices of full-timers can only be good, while recognizing that the military is a very unique and complex organization. A diversity of opinions and experiences is always valued.
Some General Naval Considerations:
According to Daniel Sing:
"The principal purpose of military forces is to defend a state and its people against external military aggression. Well trained and equipped military forces which can satisfy this over-arching goal are also well positioned to perform less exacting tasks such as sovereignty patrols, humanitarian assistance and peacekeeping. When not engaged in existential missions, military forces can and should be used in pursuit of peace and security interests abroad. Naval forces have been particularly adept at rapidly redeploying to mount UN peace support operations."
According to Norman Friedman:
"Warships are the clearest expression of national sovereignty. They are literally national territory, and they are independent enough (compared with, say, troops or land-based aircraft) that the national government can use them as it wants, depending on their capabilities. To the extent that Canada pursues an independent foreign policy, ships are probably the best military way of enforcing it.
Much of our coastal security, and search and rescue capabilities are performed by the Coast Guard (one of the many other governmental departments that the RCN routinely works alongside)."
And now for something different:
Heart of Oak:
Come cheer up my lads, tis to glory we steer,
To add something new to this wonderful year;
Tis to honor we call, you as free men not slaves,
For who are so free as the sons of the waves.
Heart of oak our ships, jolly tars our men,
We always are ready, steady boys, steady.
We'll fight and we'll conquer again, and again.
We ne'er see our foes, but we wish them to stay;
They always see us and they wish us away;
If they run we will follow, we will drive them ashore;
For if they won't fight we can do no more.
They say they'll invaded us, these terrible foes;
Frighten our women, our children, our beaus;
But should their flat-bottoms, in darkness get o'er,
Stout Britons they'll find to defeat them ashore.
Britannia triumphant, her ships rule the seas,
Her watchword is justice, her password is free.
So come cheer up my lads, with one heart let us sing,
Our soldiers, our sailors, our statesmen, our Queen.
(Chorus X2)
The reputable academic journal Canadian Navy Review (the source of the quotations above) provides free access to old issues, and can be found here: www.navalreview.ca/
Information on naval tradition can be found on the site www.ReadyAyeReady.com


text:
ECWR Participates in launching "Combating Violence against Women" Unit At Assiut University
(Cairo October 12th, 2016) ECWR participates in launching a unit for combating sexual harassment at Assiut University. The event was held in the presence of Dr. Maya Morsi, President of Egypt's National Council for Women, Mr. Alexander Pedroza, Representative of the United Nations Population Fund (UNFPA),His Excellency, Toro Hogg, Ambassador of Embassy of Denmark in Egypt, and Dr. Ahmed Ga'aeiss, President … Continue reading
Launching the Unit for Combating Sexual Harassment in Ain Shams University tomorrow
Cairo, 10th of April, 2016 On the 11th of April 2016 the "Unite for Combating Sexual Harassment" will be launched in Ain Shams University. This comes as part of the cooperation efforts of Ain Shams University, the Egyptian Center for Women Rights (ECWR), and with the support of Swedish International Development Agency (SIDA) and The United Nations Population Fund in … Continue reading


text:
Women's Polo Shirt
Sales Terms & Specifications:
|Model No.
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|FOB / CIF / EXW(Factory Price)
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T-ShirtFeatures: 1) Made of knitted silk material 2) Soft and comfortable 3) Full size range 4) Small orders accepted


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FDA Approves Novartis Kisqali As Metastatic Breast Cancer Treatment
Fresh hope for women suffering from metastatic breast cancer after the onset of menopause: the latest drug developed by Novartis AG to combat this condition has just been approved as first-line treatment for the disease.
The new drug, Kisqali, is part of an endocrine-based therapy designed to fight an advanced type of breast tumor known as HR+/HER2-, with high prevalence among postmenopausal cancer patients.
Reports by the American Cancer Society reveal approximately 40 percent of U.S. women battling breast tumors are affected by metastatic breast cancer.
The Swiss pharmaceutical company announced in a press release the recently approved medication — available in pill form — targets two proteins that activate the growth and division process of cancer cells, reducing the spread of the tumor.
Novartis, a leading company in the development of cancer medicines, also indicates Kisqali is intended to be administered alongside a previously issued cancer drug called letrozole, which follows a different course of action in battling breast tumors.
"This is an important therapy for these patients" who are faced with limited therapeutic options, said Dr. Vas Narasimhan, chief medical officer and head of drug development at Novartis.
The U.S. Food and Drug Administration confirmed the approval of Kisqali, which belongs to a class of pharmaceuticals called kinase inhibitors, on March 13.
Costs And Treatment Cycles
Kisqali and letrozole work as a combination treatment, spanning for a four-week therapy cycle. Kisqali is intended to be administered every day during the first three weeks, following a one-week pause.
In the course of the four weeks, patients are also given letrozole, which can be substituted for another aromatase inhibitor, contingent on the aspects of their condition.
According to Novartis, a month's supply of Kisqali, respectively 21 pills, will be listed at prices varying from $10,950 for the strongest dose (600 milligrams), $8,760 for the 400-milligram dose, and $4,380 for the 200-milligram dose.
Since women suffering from metastatic breast cancer generally need to go from one dose to another, the 200-milligram variant of the pill is estimated to be more cost effective.
In addition, the Swiss drug manufacturer disclosed its plans to offer patients various types of financial assistance, thus allowing many women to avoid making co-payments.
Possible Side Effects
A clinical study involving 668 women determined that the combination treatment of Kisqali plus letrozole has successfully decreased the risk of death as well as the exacerbation of the tumor by 44 percent. These results were monitored in comparison with patients treated only with letrozole.
The study, funded by Novartis, also allowed the Swiss company to observe and report any possible side effects of Kisqali, particularly the drugs' active ingredient, ribociclib.
These side effects include potentially lethal abnormal heartbeat, severe hepatic problems, strong infections, nausea, hair loss, and fatigue. Kisqali is contraindicated to pregnant or breastfeeding women.
Novartis, who developed the drug in collaboration with Astex Pharmaceuticals, a subsidiary of Japan's Otsuka Group, informs of ongoing additional studies of Kisqali in combination with other treatments for premenopausal women.
Photo: Ed Uthman | Flickr