text:
In these days of micro-managed-mega-branding, corporations search far and wide to come up with the perfect positioning statement. Something that will stir the hearts and minds of all who see it. Searching through the Computex B-roll, it seems that our happy snappy chappies captured the next evolution of AMD's messaging. …Read More »
Home / Tag Archives: amd slogan


text:
Best Vein Center In Washington DC has invasive vein treatment procedure. Venous Health Center offers to treat varicose or spider veins painless treatment.
VenousHealthCenters`s Uploads
This user didn't upload any Music or Audio file yet...
VenousHealthCenters`s Activity
VenousHealthCenters`s Followers
scotty.goodman1 from Miami Beach joined
VenousHealthCenters`s Following
VenousHealthCenters`s Audio Likes
VenousHealthCenters`s Audio Playlists
- VenousHealthCenters
- profile viewed 41 times

subset: commoncrawl


text:
Once you set your goals properly, you'll embark with Ric on a detailed exploration of personal investing. Ric reveals his formula for creating a plan to achieve your goals, build your financial future, and finance your dreams, all through his unique, time-tested investing strategies.
By following Ric's plans and guidelines, you can achieve a healthy, balanced, and richly rewarding life. Anyone can do it, he stresses, with the tools and techniques he provides. So, join Ric and discover the wealth within you.
©2002 Ric Edelman; (P)2002 HarperCollins Publishers, Inc.
"Mostly good advice with one MAJOR flaw."
Edelman is a big time financial planner and he doesn't let you forget it. His friendly and easy to understand exhortations are all more or less on the money and well worth heeding, except for one major exception--he is heavily biased toward mutual funds and talks down privately managed or "wrap" accounts. The reasoning he gives for this is very weak. For example: the minimums are too large (says who?); they tempt investors to micromanage their stocks in the accounts (huh?); they generate too much paperwork and you'll need to buy a new filing cabinet (wrong: you can opt out easily and palm this job off to an advisor--like Mr. Edelman!) This major flaw by itself does individual investors a huge disservice and frankly, I detect a large dollop of self-serving here.
Privately managed accounts are a valuable and efficient option that is available increasingly to "smaller" investors, often for as little as $10,000 and they are the universally preferred choice for substantial investors, both individual and institutional. That being said, mutual funds do have their place in today's markets. Almost no other vehicle works as well in 401(k)s or other "systematic" investment programs for example. But they certainly should not be the only choice.
If Edelman had been more rigorously objective about all the options available to investors and not lamely promoted his personal preferences to the complete exclusion of others, this program would have gotten 5 stars. If you can tune out this one major bug, go buy it. It'll help you navigate the investment jungle better.
Report Inappropriate Content
If you find this review inappropriate and think it should be removed from our site, let us know. This report will be reviewed by Audible and we will take appropriate action.


text:
The Deluxe with Bacon & Cheese
Prime beef, back bacon and cheese. The ultimate combo.
The go-to topping for any burger fanatic. Flame grilled prime beef, succulent back bacon and melted cheese all covered in Rustlers sauce that delivers a full-on satisfying feast. Definitely not a burger for sharing.
More info…
Microwave: From Chilled
1. Remove the plastic packaging then heat on full power as outlined below. Garnish with cheese slice and Rustlers sauce.
- 800W: 110 seconds
- 900W: 100 seconds
- Stand for: 30 seconds.
2. Ensure food is piping hot before serving.
For the perfect bun heat burger on full power reducing the cooking time by 20 seconds and toast bun.
Although great care has been taken to remove all bone some may remain.
You can buy the Rustlers Deluxe with Bacon & Cheese at the following stockists:
Typical values per 100g:
- Energy: 1104kJ
- Energy: 263kcal
- Fat: 13.7g
- of which saturates: 5.6g
- Carbohydrate: 20.8g
- of which sugars: 2.8g
- Protein: 14.1g
- Salt: 1.4g
Contains Barley, Wheat, Eggs, Soya, Sesame


text:
David Hare is such a master playwright in his sublime ability to blend ideas and philosophical debate into the flesh and blood of real characters. The Judas Kiss is a deeply moving and thoughtful rendition of the night Oscar Wilde refuses to run from his imprisonment and, in the second act, some years later in Naples, how he negotiates his ruin.
Lachlan Philpot continues to make theatre that cuts edges in both style and subject matter. In this play, based on the story of Harry Crawford (born Eugenia Falleni, also known as Eugene Falleni and Jean Ford) a female-to-male transgender man convicted in 1920 of the murder of his first wife, Annie Birkett, Philpott imagines the complexities of sustaining such a secret and the constant threat of what exposure might bring.
Newby Queensland playwright Michelle Law has given us a comedy crackling with authentic Asian flavours as part of the BrisAsia Festival.
Single Asian Femalefollows restaurant-owner Pearl and her two daughters Mei and Zoe as they approach a crossroad in their lives.
The play is only five minutes old when Pauline Hanson's name is volleyed off the dark walls of La Boite's Roundhouse Theatre, but Law's play focuses less on politicking and more on social attitudes around race and gender equality.
Black Box Performing Arts is a new community theatre company, specialising in Youth Musicals. They have kicked off with a bang, in what will be one of the biggest community shows of the year.
Featuring 52 talented musical theatre performers under 18, a couple of capable grown-ups, a solid young six-piece band and the support of a huge team - this is a company with great potential.
With the core-cast completely double cast, (the alternate cast moving into the ensemble) my review refers to the Green Cast.
The publicity for this production had been very favourable. I was, however, extremely disappointed. The premise and the intention behind the production may be admirable, but the actual execution was not.
This production evokes a time that's gone but not forgotten. Louise Seger (played with vivacity by Mandi Lodge) tells of how she became a fan of Patsy Cline, first by hearing her songs on the radio and calling the DJ to ask for the them to be played again, and then how she met Patsy Cline at a concert and how their friendship developed. Her descriptions almost make you see the workmates and friends she's with, and the house she lives in and of course, her much-loved automobile.
There's nothing at all faulty about Faulty Towers the Dining Experience; it's a slick two hours of fun and fab food.
Not in any way linked to the TV show Fawlty Towers except, of course, by default through the characterisation of the three actors involved in this dinner show, Faulty Towers the Dining Experience is a product of the Queensland arm of Interactive Theatre International.
With one of the roughest lead ups to reaching the stage at Fringe World, Amy Housewine - Back to Crack suffered a succession of cancelled venues and date changes before finding a home Downstairs at the Maj, where performer Lisa Adam played to sell-out crowds. To add additional stress, Friday evening's show was delayed by a fire evacuation. Fortunately Amy took it in her stride, "Who knew that a bong would set off the alarms?'
At only 22, Sydney comedian Neel Kolhatkar has plenty of comic experience. He interacts with the audience with confidence and ease, with hilarious results. Poking fun at our differences without offending can be a fine line, but he does it with ease and likeability. Not afraid to laugh at his own Indian heritage and make comedy gold out of stereotypes, he has the audience in stitches within moments of stepping on the stage.
Being greeted with 'fortune-cookie-style' paper tidbits of hometown wisdom on our seats is just about the perfect way to begin a Cabaret act entitled Radelaide!
Lucy Gransbury is a tightly-wound, beautifully-bejewelled, rapid-fire delight - with quiz question cards that sparkle even brighter than her dazzling dress! At times a lament, but far more often a tribute, to this "heaps good" city of churches, Gransbury's fantastically funny show is accompanied by Josh Belperio on Keyboard (a Kurzweil? Very Kool!)
To keep up with the latest news and reviews at Stage Whispers, click here to like us on Facebook, or follow us on Twitter.
Copyright © 2013 Stage Whispers. All Rights Reserved | Terms & Conditions
Web Development by XWeb


text: Can't find a thread like this so........ MODS - Can you make sticky sub folders under ROMS for Adrenylyne, Necosino, Jager, ect. That way they have their own sub-folder for all their Roms. And create a NEW CHEFS folder so aspiring chefs can post their roms. Once a new chef creates so many stable roms or reaches so many downloads they could get their own sub-folder. This is just a suggestion. It may help us to locate our favorite chefs as well as help us find and try new chef roms. Thanks!!!! UPDATE: There is a new sticky: http://androidforums.com/incredible-roms/155282-incredible-rom-list.html I take no credit for this. This site has been created by and is being maintained by Weazol. Thanks!


text:
Aging mammals lose the ability to maintain energy balance, exhibiting decreased appetite (anorexia) and impaired ability to maintain body weight. To determine the contribution of hypothalamic neuropeptides, two experiments were performed in male Brown Norway rats. To assess the hypothalamic neuropeptide response to food deprivation, young (Y; 4 mo old), middle-aged (M; 13 mo), and old (O; 25 mo) rats were either ad libitum fed or fasted for 72 h (n = 10/group) and killed. Hypothalamic levels of agouti-related peptide (AgRP), proopiomelanocortin (POMC), and cocaine-amphetamine-regulated transcript (CART) mRNA were assessed by in situ hybridization. With aging, arcuate AgRP gene expression decreased and CART mRNA increased, but POMC mRNA did not change. Fasting-induced changes in gene expression of all neuropeptides studied were attenuated with aging. To test the food intake response to appetite-stimulating neuropeptides, Y, M, O, and very old (VO; 33 mo) rats (n = 4–8/group) received one intracerebroventricular injection of each of three treatments: 0.1 nmol AgRP, 2.34 nmol NPY, and saline control. AgRP increased food intake of all groups by 10–20%, compared with saline, and this effect persisted up to 7 days after injection. VO animals were more sensitive to the effects of AgRP than younger animals. In contrast, NPY increased food intake more in Y than in older animals and its effects did not last >24 h. We conclude that the mechanisms by which arcuate nucleus neurons influence appetite are differentially affected by age and speculate that the melanocortin system may be a useful target for treatment of the anorexia of aging.
- energy balance
- food intake
- proopiomelanocortin
- cocaine-amphetamine-regulated transcript
aging is associated with impairment in the ability to maintain energy balance in response to homeostatic perturbations. The reasons for this loss of regulation of energy balance are multifactorial. However, one of the key factors appears to be a loss of appetite, termed "the anorexia of aging" (8, 38, 43, 44). In humans, anorexia of aging is caused by numerous factors, including sensory impairment, social isolation, and psychological and physiological factors, in addition to the presence of disease (19, 38, 44). Studies have shown that healthy older people fail to respond to over- or under-feeding with the compensatory changes in eating that are observed in younger people (41–44). In addition, older people report less hunger after an overnight fast and report greater degrees of satiation to meals than do younger subjects (8, 44, 56). This apparent insensitivity to metabolic cues can lead to inappropriate weight loss in response to acute or chronic illness or other stressors, resulting in greater morbidity and mortality in geriatric populations (19, 25, 38).
Our laboratory uses the Brown Norway (BN) rat to study aging-related decrements in reproductive function and regulation of body weight (22, 36). Male BN rats are an excellent model for human aging: they have long disease-free survival rates (52) and a maximum life span of ∼36 mo, with 50% surviving to 30 mo (comparable to 80 yr of age in humans), and 10% surviving to 32 mo of age (52). Male BN rats exhibit age-related changes in circulating levels of trophic and metabolic hormones and alteration of body composition, food intake, and body weight that are consistent with those observed in aging men (36, 55).
We use the metabolic stressor of a 72-h period of food deprivation to stimulate the neuroendocrine system to reveal aging-related differences in the functioning of the hypothalamic circuitry involved in energy homeostasis. This period of food deprivation is well tolerated by all animals, and no animal has ever lost >20% of body weight under these conditions. We (21, 54) and others (30) have consistently found that, compared with young animals, aging male rats fail to increase food intake after a 72-h fast and are slow to regain lost body weight on refeeding. We observed that this inability to defend body weight is associated with an age-related deficiency of NPY mRNA and a blunted fasting-induced increase in NPY gene expression (21, 30, 54). This decreased NPY gene expression may be due to blunting of counterregulatory hormonal responses to fasting. Old BN rats are twice as fat as young (20% body fat compared with 10%), with correspondingly higher levels of the metabolic hormones leptin and insulin (55), and they remain hyperinsulinemic and hyperleptinemic at the end of a 72-h fast (21, 54).
Leptin is an adipocyte-derived hormone that provides a signal of energy sufficiency (circulating levels are proportional to energy stored in adipose tissue) to hypothalamic nuclei involved in energy homeostasis (17). In young mice and rats, high levels of exogenous leptin decrease food intake, increase energy expenditure, and decrease gene expression of appetite-stimulating (orexigenic) neuropeptides [e.g., NPY and agouti-related peptide (AgRP)] and reciprocally increase gene expression of appetite-suppressing (anorexigenic) neuropeptides that decrease food intake and increase energy expenditure [e.g., α-melanocyte stimulating hormone (α-MSH) and cocaine-amphetamine-regulated transcript (CART)] (1, 3, 26, 33). Aging and obesity appear to produce a leptin resistance, which blunts these responses to exogenous leptin and leads to hyperleptinemia as the system strives toward homeostasis (21, 23, 30, 45, 48, 50, 54). Fasting causes a rapid decrease in endogenous leptin levels; it is this acute decrease in leptin that signals to the hypothalamus that energy stores may be compromised, resulting in increases in NPY and AgRP gene expression, which the organism interprets as increased hunger and, when food is present, stimulates food intake (1, 17). It is likely that the relatively hyperleptinemic state of aging animals blunts the sensitivity of the hypothalamic energy regulatory system, thus decreasing appetite even during episodes of negative energy balance, such as would occur during an acute illness or caused by other stressors.
Although NPY has long been recognized to play a role in the control of energy balance, the presence of normal feeding and body weight in NPY knockout mice indicates that NPY is not required for maintenance of energy balance when food is freely available (2, 35, 40). Recent evidence has implicated the hypothalamic melanocortin system as a key regulator in the maintenance of energy balance (7, 9, 11, 12, 27). Work from a number of laboratories has identified a circuitry of neurons in the arcuate nucleus that integrates peripheral metabolic signals and regulates appetite and energy expenditure through actions on distal effector neurons (7, 9, 11, 12, 27). This circuit consists of the neurons coexpressing the anabolic neuropeptides AgRP and NPY, which synapse on and inhibit the firing of neurons coexpressing the catabolic neuropeptides α-MSH [derived from proopiomelanocortin (POMC)] and CART. The AgRP-NPY and POMC-CART neurons synapse on each other; both project rostrally to second-order neurons in the paraventricular nucleus (PVN) and caudally to other second-order hypothalamic and extrahypothalamic sites that are involved in the autonomic and behavioral processes that regulate energy balance (9, 11, 15, 17, 28). Neuronal integration in this complex network of neurons is under intensive investigation, and it is clear that this network responds to many hormonal and metabolic signals, including leptin, insulin, ghrelin, corticosterone, and glucose.
NPY and AgRP are anabolic neuropeptides that stimulate feeding and inhibit sympathetic activity when exogenously applied to the hypothalamus of rats (4, 24, 37), although the feeding response to NPY is diminished in senescent rats that are undergoing terminal weight loss (4). Leptin, the catabolic hormone that decreases food intake and increases energy expenditure in young rats, also has blunted effectiveness in aging F344 and F344 × BN F1 hybrid rats (45–48, 53). The ability of AgRP to increase food intake of aging rats has not been investigated.
We hypothesized that the dysregulation of energy balance associated with aging results from reduced anabolic signaling through AgRP-NPY neurons and increased catabolic signaling through POMC-CART neurons. Experiment 1 assessed the effect of age on changes in AgRP, POMC, and CART gene expression in response to a 72-h fast in young (Y), middle-aged (M), and old (O) male BN rats (ages 4–25 mo) and correlated neuropeptide expression with levels of their hormone mediators. We further hypothesized that the age-associated alterations in energy regulation result from an inherent inability of the aging system to appropriately respond to neuroendocrine signals. Experiment 2 compared the ability of centrally administered AgRP and NPY to increase food intake in Y, M, O, and very old (VO) male BN rats (ages 4–33 mo).
Adult male inbred, specific pathogen-free (SPF) BN/Bi, rats were purchased under National Institutes of Aging contract from Harlan Sprague-Dawley (Indianapolis, IN). Animals were isolated in a dedicated room containing no other animals, in a modified specific pathogen-free American Association for Accreditation of Laboratory Animal Care-accredited facility at the Veterans Affairs (VA) Puget Sound Health Care System in Seattle, WA. Animals were individually housed in polycarbonate rat cages containing corncob bedding in a light- and temperature-controlled room on a 12:12-h light/dark cycle (lights off from 1800 to 0600). Except where noted, animals were allowed ad libitum access to Purina rodent chow (5001, Ralston Purina, St. Louis, MO) and tap water. All animal experiments were conducted in accordance with the principles and procedures outlined in the National Institutes of Health Guide for the Care and Use of Laboratory Animals and were approved by the VA Institutional Animal Care and Use Committee.
Experiment 1
Three age groups (n = 20/age group) of male BN rats (Y: 3 mo; MA: 12 mo; O: 24 mo) were studied. After a 30-day baseline period, one-half of the animals were subjected to a 72-h fast, whereas the other one-half continued to be fed ad libitum. Body weights were monitored daily, and no animal lost >20% of prefasting body weight. At the end of 72 h, all rats were killed by decapitation between 0930 and 1200; brains were quickly removed, frozen on dry ice, and stored intact at −70°C for sectioning and in situ hybridization. Trunk blood was collected and serum was separated for assay of leptin, insulin, corticosterone, testosterone, ghrelin, and thyroxine.
Tissue processing.
Serial 20-μm coronal sections (1:3 series) were prepared from each frozen brain using a Jung Frigocut cryostat. Brains were cut through the hypothalamus, from the point rostral to the flattening of the optic chiasm to the rostral pole of the mammillary bodies. Sections were thaw-mounted onto RNase-free microscope slides (Superfrost Plus, Fisher Scientific, Pittsburgh, PA) and stored at −70°C until they were prepared for hybridization as previously described (21, 50, 54). Adjacent sets of sections were used for the following in situ hybridizations.
AgRP in situ hybridization.
DNA complimentary to nucleotides 1–396 of rat AgRP mRNA (U89484) was synthesized by PCR amplification [gift from TM Hahn and MW Schwartz, University of Washington (3, 26)] and used for riboprobe preparation. Purified linearized DNA (0.5 μg/μl) was transcribed (Riboprobe system T-7, Promega #P1440, Madison, WI) with [35S]dUTP (New England Nuclear). Labeled probe mixture (including yeast tRNA, Tris-EDTA-dithiothreitol, and dithiothreitol) was diluted in hybridization buffer to a concentration of 0.6 pmol/ml and applied to each slide. Coverslipped slides were incubated overnight at 63°C. Coverslips were removed in 1× SSC, slides were loaded into slide racks and washed in 1× SSC for 30 min at room temperature, followed by 30-min wash in RNase buffer at 37°C and a further 30-min wash in 1× SSC at room temperature. Three 20-min stringent washes (0.1× SSC at 68°C) were followed by a final 30-min wash in 0.1× SSC at room temperature. Sections were dehydrated through a series of ethanol solutions and air-dried. When dried, slides were apposed to Hyperfilm-βMax film for 6 days, and films were processed using Kodak Developer D19 and Rapid Fix. AgRP mRNA levels were quantitated throughout the entire arcuate nucleus of each brain using film autoradiography digitized with an image analysis system (MCID; Imaging Research, St Catharines Ontario, Canada). One operator, who was blinded to the age and condition of the subjects, performed image analysis. For each brain section showing signal, hybridization area (mm2) was quantified by establishing a threshold value and determining the suprathreshold area (corrected for background labeling) with a predetermined template encompassing only the area of interest. The average optical density and hybridization area for each section were determined by the image analysis software, and the product of the optical density and hybridization area (expressed as hybridization units) was used as an index of the total amount of hybridization in the arcuate nucleus (21, 50, 54).
POMC in situ hybridization.
A 24-base oligodeoxynucleotide probe, complementary to the region of rat POMC coding for corticotrophin residues 8–15, was synthesized by the Molecular Biology Core facility at the Seattle VA. Probe was purified in our laboratory, 3′-end labeled with [35S]dATP (New England Nuclear), further purified (NENSORB 20, New England Nuclear), and reconstituted as described previously (21, 23). Labeled probe mixture (including yeast tRNA, TED, and dithiothreitol) was diluted in hybridization buffer. Aliquots were applied to each slide, coverslipped, and incubated overnight at 27°C. Coverslips were removed in 1× SSC, and slides were loaded into slide racks and washed four times for 15 min each at 55°C in 1× SSC and again for 30 min at room temperature. Sections were then dehydrated and placed on Hyperfilm-βMax film for 78 h, and films were processed as above. POMC mRNA levels were quantitated throughout the entire arcuate nucleus of each brain using film autoradiography digitized using the MCID image analysis system, as described above.
CART in situ hybridization.
DNA complimentary to nucleotides 20–409 of rat ppCART mRNA (accession number U10071) was synthesized by PCR amplification (gift from TM Hahn and MW Schwartz, University of Washington) and used for riboprobe preparation. Purified linearized DNA (0.5 μg/μl) was transcribed (Riboprobe system T-7, Promega #P1440) with [35S]dUTP (New England Nuclear). Labeled probe mixture (0.4 pmol/ml) was applied to each slide, and slides were incubated overnight at 65°C, as previously described (50). Dried slides were apposed to Hyperfilm-βMax film for 26 h, and films were processed as above. Total CART mRNA levels were quantitated throughout the PVN, arcuate nucleus, and dorsomedial hypothalamus (DMH) of each brain, using film autoradiography digitized with the MCID image analysis system, as described above. The patterns of CART gene expression in this study are consistent with previous studies demonstrating the distribution of CART mRNA in the hypothalamus (10, 13, 16, 34).
Hormone assays.
Serum was stored at −30°C until hormone assays were performed on duplicate samples. Serum leptin, insulin, corticosterone, and ghrelin levels were determined by double antibody radioimmunoassay kits (rat leptin: RL-83K; rat insulin: RI-13K, Linco, St. Louis, MO; rat corticosterone: 07–120103, ICN Diagnostics, Costa Mesa, CA; rat ghrelin RK-031–31, Phoenix Pharmaceuticals, Belmont, CA). The detection limit of the rat leptin assay is 0.5 ng/ml; intra-assay variability is 7.2%. The detection limit of the rat insulin assay is 0.1 ng/ml, and the intra-assay variability is 3%. The detection limit of the rat corticosterone assay is 0.2 ng/ml and is 0.16 ng/ml for rat ghrelin assay. Total serum testosterone and thyroxine were measured by fluoroimmunoassay (Delfia testosterone: A050–101; thyroxine: 1244–030, Wallac Oy, Turku, Finland). Detection limit of the testosterone assay is 0.1 ng/ml and intra-assay variability is 3.1%. The limit of detection of the thyroxine assay is 39 ng/ml.
Statistical analyses.
Leptin and other hormone levels were compared by two-way ANOVA, as were body weights, weight change during the fast, and CART, AgRP, and POMC in situ hybridization data. Results are reported as means ± SE, and level of significance was set at P < 0.05. Post hoc testing by Fisher's protected least-significant difference (PLSD) was performed for between-treatment differences separately for each age group. The statistical software package used was StatView Version 4.57 for Windows (Abacus Concepts and SAS Institute, Berkeley, CA).
Experiment 2
Y (4 mo; n = 5), M (13 mo; n = 5), O (25 mo; n = 4), and VO (33 mo; n = 8) weight-stable male BN rats were implanted with third ventricular cannulas (Plastics One; 2.2 mm caudal to bregma and 7.5 mm below dura) while under isoflurane anesthesia. Surgical recovery was supported with warmed subcutaneous fluids (lactated Ringer saline; 5 ml/250 g body wt), and cages were placed on circulating-water heating pads until animals were completely awake and ambulatory. Antibiotic (gentamicin; 8 mg/rat) and anti-inflammatory (ketoprofen; 5 mg/kg) therapies were administered for 3 days. Cannula patency was tested using the dipsogenic hormone ANG II no less than 1 wk after surgery. Animals were considered to have a functioning cannula if they drank at least 5 ml of water within 15 min of injection of 50–100 ng ANG. After cannula patency testing, each animal received one injection (2–5 μl) of each treatment, administered in the early part of the light phase, 3–4 h after lights-on. Animals were injected with 0.1 nmol AgRP [AgRP-(86–132); Peptides International], 2.34 nmol NPY (10 μg, Sigma), and saline vehicle as control. The AgRP dosage that was chosen has been shown to stimulate food intake for up to 7 days in young rats (14, 24, 31, 32, 49, 57). The NPY dosage that was chosen has been shown to be the maximal dosage that stimulates food intake in old F344 rats but that fails to do so in animals undergoing senescent terminal weight loss (4). Treatment order was counterbalanced, and treatments were separated by at least 7 days. After injection, animals were returned to their home cages and given a weighed supply of regular rodent chow, which was weighed to the nearest 0.1 g after 4 and 24 h, and daily thereafter (fresh food was supplied daily and all animals were accustomed to the feeding protocol). Body weights were also measured daily.
Statistical analyses.
Food intake measurements are reported as means ± SE. Results were compared by two-way repeated-measures ANOVA; the level of significance was set at P < 0.05. Post hoc testing by paired Student's t-tests was performed for between-treatment differences separately for each age group. The statistical software package used was StatView Version 4.57 for Windows (Abacus Concepts and SAS Institute).
Experiment 1
Body weights.
Initial body weights of rats were significantly greater (P < 0.0001) with increasing age (Table 1). Animals that were subjected to a 72-h fast lost around 50 g of body weight, regardless of their age, resulting in a greater percentage of body weight loss in Y animals, compared with M and O rats (Table 1). Little change in weight was observed in the ad libitum-fed animals during this 72-h period.
AgRP gene expression.
AgRP mRNA hybridization in the entire arcuate nucleus decreased with age (P < 0.0001) and increased with fasting (P < 0.0001; Fig. 1); both signal density and signal area were increased. Total hybridization units in fasted rats were significantly increased by twofold in all groups of rats compared with ad libitum-fed animals.
POMC gene expression.
POMC mRNA hybridization in the arcuate nucleus was similar between all ages of ad libitum-fed rats (Fig. 1). Fasting (72 h) significantly (P < 0.0001) decreased POMC gene expression (both decreased signal density and decreased signal area). Total hybridization units in fasted rats were 57, 27, and 13% lower in Y, M, and O fed rats, respectively; this decrease was significant for Y and M groups only.
CART gene expression.
CART mRNA hybridization in the entire arcuate nucleus increased with age (P < 0.0001) and decreased with fasting (P < 0.0001; Fig. 1). Total hybridization units in fasted rats were 48, 33, and 19% lower in Y, M, and O fed rats, respectively; this decrease was significant for each age group.
In the PVN, CART mRNA hybridization decreased with age (P < 0.0001) and fasting (P = 0.0003; Fig. 2). Both signal density and signal area were decreased, although signal density was less sensitive to fasting than to age, whereas signal area was less sensitive to age than to fasting. Total hybridization units in fasted rats were 6, 25, and 15% lower in Y, M, and O rats, respectively; this decrease was significant only for the M group.
CART mRNA hybridization in the perifornical region of the DMH was not altered either by age or by fasting (data not shown).
Serum hormone levels.
Levels of serum insulin were increased with age (P < 0.0001; Table 1) in both fed and fasted groups. Insulin levels of O animals in the fed group were threefold higher than in Y fed rats and twofold higher than in M fed rats. Fasting significantly (P < 0.0001) decreased insulin by 70–80% in all age groups.
Serum leptin levels were also increased with age (P < 0.0001; Table 1) in both fed and fasted groups; however, age-related differences were more pronounced than for insulin. Leptin levels of O animals in the fed group were sevenfold higher than in Y and threefold higher than M rats. Fasting significantly (P < 0.0001) decreased leptin by 60–70% in all age groups.
Serum corticosterone levels were significantly lower with increasing age (P < 0.0001; Table 1) in both fed and fasted groups. Fasting significantly (P < 0.002) increased corticosterone by 166, 183, and 126% in Y, M, and O rats, respectively.
Levels of serum testosterone were similar between fed groups of O and M animals and were decreased compared with Y rats (P < 0.07; Table 1). Fasting significantly (P < 0.0001) decreased testosterone by 94, 65, and 72% in Y, M, and O rats, respectively. Testosterone levels of the Y fasted animals were reduced to or below the lower limit of the assay.
Serum thyroxine levels were similar between groups of O and M animals and were decreased compared with Y rats (P < 0.05; Table 1). Fasting significantly (P < 0.0001) decreased thyroxine by 20, 10, and 8% in Y, M, and O rats, respectively.
Serum ghrelin levels were similar between fed groups of rats. Fasting significantly (P < 0.0001; Table 1) increased serum ghrelin by 70, 41, and 25% in Y, M, and O rats, respectively.
Correlations between mRNA levels and hormones.
Correlations between mRNA levels and serum hormones (Table 2) indicate that leptin and insulin were positively associated with gene expression of the anorexigenic neuropeptides POMC and CART in the arcuate nucleus and negatively associated with gene expression of the orexigenic neuropeptide AgRP. In contrast, corticosterone and ghrelin were positively associated with AgRP mRNA and negatively correlated with POMC and CART mRNA levels in the arcuate nucleus. Testosterone and thyroxine were negatively correlated with arcuate AgRP, positively associated with POMC gene expression, and positively associated with CART mRNA levels in the PVN and the dorsomedial hypothalamus.
Experiment 2
There was no significant effect of age on food intake of the saline group at any time point, although food intake tended to be lower in Y and greater in O compared with M and VO animals (Figs. 3 and 4). Both AgRP and NPY stimulated feeding at 4 and 24 h after third ventricular injections during the light phase, compared with saline (P < 0.001; Fig. 3). Cumulative daytime food intake 4 h after 2.34 nmol injection of NPY was greater than food intake after 0.1 nmol AgRP, but by 24 h the effect of NPY was abolished in all but the Y animals (Fig. 3). In contrast, AgRP continued to stimulate food intake for 24 h (P < 0.001; Fig. 3) and a single third ventricular injection significantly increased 3- and 7-day cumulative food intake by 10–20% compared with saline injection (P < 0.001; Fig. 4). The ability of AgRP to increase food intake was more pronounced in VO animals than it was in Y (Fig. 4). Individual daily food intake was increased by 2–4 g for as many as 7 days after the single injection compared with average food intake after saline (P < 0.001). Body weights of Y animals were significantly lower than older animals, whose weights did not differ significantly. Body weights were not affected by any treatment for any age group. Final body weights per age group: 3–4 mo (Y), 285 ± 11, range 245–316 g; 12–13 mo (M), 415 ± 3, range 404–424 g; 24–25 mo (O), 457 ± 16, range 407–500 g; 32–33 mo (VO), 450 ± 11, range 394–495 g.
These studies have revealed an age-associated decrease in basal arcuate nucleus AgRP gene expression that is of the same magnitude as we previously showed for arcuate NPY gene expression (21, 23, 50, 54). We also found that POMC mRNA levels in the arcuate nucleus were not altered with age in the basal state and we confirmed and extended our earlier (50) finding of an age-associated increase in CART mRNA in the arcuate nucleus and an age-associated decrease in CART mRNA in the PVN. We confirmed the finding (4) that the food intake response evoked by exogenous NPY is blunted in aging animals, and we showed for the first time that the prolonged feeding response to exogenous AgRP was maintained in old BN rats. The results of this study confirmed our hypothesis that age-associated decrements in levels of orexigenic signaling through AgRP/NPY neurons in the arcuate nucleus are accompanied by increased levels of anorexigenic signaling through POMC/CART neurons. This pattern of neuropeptide gene expression may contribute to a loss of appetite and the anorexia of aging.
Old animals may remain weight stable when food is freely available, but experiments using metabolic perturbations have demonstrated failures in the ability of aging animals to regulate energy balance (4, 21, 23, 30, 45, 48, 54). The negative energy balance induced by a 72-h fast increased gene expression of the orexigenic neuropeptide AgRP [a similar magnitude as the fasting-induced NPY increase (21, 54)] and decreased expression of anorexigenic neuropeptides CART and POMC. Food deprivation for 72 h revealed that old animals failed to reduce POMC mRNA and that fasting-induced decreases in CART mRNA were blunted in the old animals compared with Y and M rats. Although AgRP mRNA levels doubled with fasting in all age groups, levels in fasted old rats were not different from those in ad libitum-fed young animals, similar to the pattern seen for NPY mRNA in previous studies (21, 23, 54). These findings indicate that in addition to the attenuated orexigenic drive, aging animals also showed incomplete suppression of anorexigenic drive, possibly driven by blunted endocrine responses to fasting.
Because AgRP gene expression was reduced in old animals, we sought to determine whether the aging melanocortin system was able to respond to centrally administered AgRP or whether aging would dampen responsivity to exogenous AgRP as is the case for NPY (4). We found that, contrary to our hypothesis that the aging system has an inherent inability to appropriately respond to neuroendocrine signals, the aging melanocortin system is able to respond appropriately to exogenous AgRP, whereas at the same time showing blunted responses to NPY. We observed that a dose of AgRP, shown by others to be submaximal but long-lasting (14, 24, 49), stimulated food intake equally well in aged rats as in young rats. In contrast, exogenous NPY increased short-term food intake more than did AgRP but was far less effective in older animals than in young, a finding that confirms studies in other strains of aging rats (4, 39). The loss of responsivity to exogenous NPY may be due, in part, to pharmacologic actions on different NPY receptor subtypes, suppressing endogenous NPY release via Y2 autoreceptors on arcuate nucleus NPY/AgRP neurons, whereas simultaneously stimulating second-order neurons through actions on the Y1 and Y5 receptors (9, 11).
Aging mammals have increased total and peripheral fat mass, with a proportional increase in leptin and insulin. We previously showed that total adiposity (as determined by dual energy X-ray absorptiometry) increases from 9% at 3 mo to 20% at 29 mo of age in male BN rats (55). Although body fat is twice as high in aged compared with young male BN rats, circulating leptin levels are six- to sevenfold higher in the old animals, even at the end of the 72-h fast. Thus aging male BN rats appear to be in a chronically hyperleptinemic state. Our findings of decreased orexigenic and increased anorexigenic signaling with advancing age may indicate that aging BN rats maintain at least partial responsiveness to endogenous leptin, in contrast to aged F344 × BN F1 hybrid rats, which are resistant to the effects of exogenous leptin (45–48). This leptin resistance may be due to a leptin dosage effect, as the F344/BN males are fatter and have higher levels of leptin compared with the BN males (47).
Energy balance results from a homeostatic feedback system that is regulated, in part, by endocrine signals acting on neurons in the arcuate nucleus that integrate peripheral metabolic signals and regulate appetite and energy expenditure (1, 7, 12, 27). When leptin and insulin levels are high, such as in a fed or satiated state, metabolic rate is increased and food intake is decreased. When food is scarce, leptin and insulin levels decrease, hunger signals increase, and metabolic rate is decreased to conserve energy stores. Compared with young animals, the aging male BN rat has high levels of insulin and leptin and lower levels of testosterone, thyroxine, ghrelin, and corticosterone. When confronted with a lack of food, insulin, leptin, testosterone, and thyroxine are reduced and ghrelin and corticosterone are increased. These appropriate responses to food restriction reduce energy expenditure and increase hunger and food-seeking behavior, because the hypothalamic systems that regulate energy balance are responsive to changes in the levels of these hormones. The metabolic challenge of a 72-h fast resulted in altered levels of these hormone mediators of energy balance, although fasting-induced changes were attenuated in aging rats. We showed previously (54) that treatment with the insulin sensitizer troglitazone ameliorated hyperinsulinemia and hyperleptinemia in old male BN rats and improved food intake and body weight gain after a 72-h fast, suggesting that age-related increases in these hormonal signals of energy sufficiency play a role in the attenuated food intake that we observe in old animals after fasting. Troglitazone-induced improvements in food intake and body weight recovery (54) occurred without changes in arcuate NPY gene expression, suggesting that other neuropeptide systems may have been involved.
Exogenous leptin and insulin activate POMC/CART neurons and suppress activity of NPY/AgRP neurons (3, 15), whereas exogenous ghrelin activates NPY/AgRP neurons and suppresses activity of POMC/CART neurons (9, 29). The degree to which this circuitry is influenced by other endocrine mediators is just beginning to be understood. We found that high levels of the catabolic neuroendocrine mediators leptin and insulin were correlated with suppressed levels of AgRP mRNA and with increased levels of CART and POMC mRNA, both in the basal and fasted state. Similarly, reduced anabolic signaling (via ghrelin and corticosterone) was correlated with suppressed orexigenic and increased anorexigenic neuropeptide gene expression. Serum testosterone and thyroxine levels were negatively correlated with arcuate nucleus AgRP, positively correlated with arcuate nucleus POMC, and positively associated with CART gene expression in the PVN and DMH, suggesting that the neuromodulatory actions of these hormones may be more complex, perhaps because of their roles in growth, reproduction, and autonomic function. CART is colocalized with a number of neuropeptides in the PVN (6, 18, 51), including TRH, vasopressin, and oxytocin, all of which are decreased with aging or with low levels of testosterone resulting from castration or aging (5, 20). Intracerebroventricular injections of CART have been shown to prevent the fasting-induced decrease in TRH mRNA (18), and it may be that the decreased CART gene expression that we observed in the PVN of older, fasted animals reflected a counterregulatory response to decrease energy expenditure via thyroxine's effects on the autonomic nervous system.
In summary, using in situ hybridization, we found decreased gene expression of orexigenic (AgRP) and increased gene expression of anorexigenic (POMC and CART) neuropeptides in the arcuate nucleus with advancing age. AgRP gene expression doubled with fasting in all age groups, but levels in old fasted rats were attenuated and similar to those of young fed animals, and fasting-related reductions in POMC and CART were blunted with aging. Using intracerebroventricular injections of orexigenic neuropeptides, we found that, in contrast to a blunted and acute feeding response to NPY administration, aged animals were as sensitive to the effects of AgRP as young rats and showed stimulation of food intake for up to 1 wk after one treatment. We conclude that the mechanisms by which the colocalized AgRP and NPY systems in arcuate neurons influence appetite are differentially affected by age. Our finding of long-lasting effects of AgRP to stimulate food intake of aged rats lead us to speculate that the melanocortin system may be a useful target for treatment of the anorexia of aging.
This work was supported by Veterans Affairs Medical Research Funds and National Institutes of Health Grant P50-HD-12629.
Work in this report has been presented and published in part at the 82nd Annual meeting of the Endocrine Society, Denver, CO (2000), and at the Fifth International Melanocortin Meeting, Sunriver, OR (2002).
The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
- Copyright © 2004 the American Physiological Society


text:
I took some spur of the moment sunset iphone photos on our way to the city, by the path train. I love a good pink sunset! The skyline was just glowing, it was quite the dreamy view.
Hope you're having an OK Monday, today I'm taking it kind of easy, doing some much need things around the house. Nice and quiet day for me, an impromptu snow day of you will. It like, sucks out there right now. Stay inside!


text:
Obituary & Guest Book Preview for William Aitken Kimble
William Aitken Kimble Obituary
First 25 of 355 words
: KIMBLE William Aitken Kimble, age 88, of Pass Christian passed away April 16, 2013 in Gulfport. He was born in New Orleans, La., on April...
View Full Obituary & Guest Book for William Kimble
William Kimble Guest Book | View 2 of 11 Entries:
"To the Kimble Family, I have very fond memories of your parents who were the best of friends with my parents. They knew how to have fun! I am so sorry to hear about your Dad! You are in my prayers!..." -
"Please accept our condolences for your loss. Mary Joan & the Fitzpatricks send love & prayers." -
Mary Joan Fitzpatrick (and family)
View Additional entries from:
Previous 10
Next 10
View Complete List
View Full Obituary & Guest Book for William Kimble
Ways to View
Restore Obituary & Guest Book
Keep the Obituary and Guest Book online for one of these time periods:
Permanent Sponsorship
$ 79.99
One-Year Sponsorship
$ 29.99
24-Hour Restoration
$ 2.95
Print Obituary & Guest Book
Order a professionally printed copy, starting at $39.00:
Deluxe Hardcover Book
$ 79.00
Laminated Hardcover Book
$ 59.00
Laminated Softcover Book
$ 39.00
Didn't find the Obituary you were looking for?
Return to today's Obituaries for the The Times-Picayune.
Powered By
Search Obituaries
How To
Questions? Contact Us
© 2017 Legacy.com All Rights Reserved


text:
The South Coast region of Massachusetts is a picturesque coastal area rich in history. Comprised of Barnstable, Bristol, and Plymouth counties, the South Coast is situated along the Atlantic Ocean shoreline, bordered by Buzzards Bay to the south and Cape Cod Bay to the east, making it a popular summer destination for vacationers from around the world. The communities are well-preserved blends of classic New England charm and modern conveniences. The area's strong sense of tradition is made evident by its conservation of historic architecture, museums, lighthouses, and shipyards. Naturalists will be captivated by large areas of undeveloped land, a variety of beaches, numerous parks, an abundance of nature preserves, and the recently improved Buttonwood Park Zoo, home to nearly 200 species of animals. An array of antique shops, diverse restaurants, and a thriving arts and culture community help to deliver something for everyone in this charming area located in the heart of New England.
564 River Road
Westport, MA 02790 $2,275,000 | Land
564 River Road
Westport, MA 02790 $2,275,000 | Single Family 5 Bed | 3.1 Bath
58 Saint John ST
Dartmouth, MA 02748 $1,999,000 | Multi Family 8 Bed | 9 Bath
58 Saint John Street
Dartmouth, MA 02748 $1,999,000 | Multi-family 16 Bed | 16.2 Bath
Westport, MA 02790 $1,900,000 | Single Family 4 Bed | 3 Bath | 2,877 Sq Ft
42 Atlantic
Westport, MA 02790 $1,900,000 | Single Family 4 Bed | 3 Bath


text:
Results 1 to 4 of 4
March 4th, 2005, 10:09 AM #1problem with impression count
I have a bunch of links on my site for linkshare merchants and have always shown alot of impressions on the reports. When I log in now I have either no impressions or minimal impressions. Is this something I need to be worried about? Im showing click throughs but even they are very low which dosen't make sense. Any ideas? Thanks Melanie
March 4th, 2005, 10:20 AM #2
I have one merchant (Szul) which has been like this since late February. I know for a fact it's getting impressions every day but they stopped tracking them. I see a click every so often, so hopefully at least that side of things is working.Tim
consultant by day, affiliate by night
March 4th, 2005, 10:27 AM #3Originally Posted by infospongellc
I am working on reporting right now to reconcile what LS is showing as reporting and what our internal stats show. I did show unusual numbers last week of Feb in LS reporting. I do have all the Szul transactions and we are checking now if what we have tracked and reported is in fact showing up on LS reporting.
A note on Szul - 98% of our links are redirected by us, we have internal tracking that we can cross reference with LS in case of any discrepancies.
We batch report shipped orders so we also have internal trackng and checking. I personally have access to all data and I work directly with Szul to be sure all that is sold via the affiliate channel gets credited, reported to LS and be sure LS reports it as well.
I'm all over this my friend...Andy Rodriguez Consulting, Affiliate Program Management and Consulting Services, Since 2001
www.andyrodriguez.com | E: email@example.com | P: (888) 931-ANDY (2639) | Skype: affiliatedoctor | AIM & MSN: AffiliateDoctor | Subscribe To Our ABW Forum Posts | Follow me on Twitter | Join Our Affiliate Programs
March 4th, 2005, 10:49 AM #4
Hey Andy...
I know you're all over the tracking stuff on the sales side, so I wasn't too worried. :-) I figured the lack of impressions showing was just the usual LS situation.
- TimTim
consultant by day, affiliate by night
Similar Threads
CJ Impression Count for Affiliate WidgetBy RCruz in forum GrouponReplies: 1Last Post: October 25th, 2010, 12:14 PM
Impression Tracking?By QiSoftware in forum Commission Junction - CJReplies: 2Last Post: July 19th, 2010, 03:47 AM
Deactivated Merchants Problem, Part, 6, 7 or 8, I've Lost CountBy Trust in forum Google Affiliate Network - GANReplies: 0Last Post: September 14th, 2008, 07:26 PM
Impression UrlBy AddHandler in forum Commission Junction - CJReplies: 2Last Post: May 5th, 2005, 06:51 PM


text:
The Burts Bees Baby affiliate program offers 100% organic cotton apparel along with a host of other baby and kids products, including gifts, toys, bath, bedding, and more. Their products' manufacturing, packaging, and distribution always adhere to the highest environmental standards.
Sign up with FlexOffers.com to learn more about the Burts Bees Baby affiliate program today!


text:
Lincolnshire Branch
AreaThe Lincolnshire Branch covers Lincolnshire, North Lincolnshire, North East Lincolnshire and services on the East Coast Main Line from Retford, Newark Northgate and Grantham.
Campaigns nowWe are currently campaigning for:
- Hourly trains Lincoln–Grimsby and Lincoln–Doncaster
- Services Lincoln–Peterborough before 08.00 and after 18.00.
- Improved Sunday services on all routes.
- Restoration of regular freight services and seven days a week passenger services on the Brigg Line (Gainsborough to Barnetby).
- A station for Robin Hood Doncaster Sheffield airport at Finningley
Campaigns futureIn the longer term we wish to see:
- New or reopened stations to serve Cherry Willingham/Fiskerton, Washingborough/Heighington, Donington, Pinchbeck and the Deepings.
- A feasibility study carried out into a possible 'Park and Ride' site at Hykeham station.
- Major housing developments being planned where rail transport is already available or where stations could be constructed.
- The safeguarding of disused railway land for future rail purposes, especially where freight transfer sidings could be sited.
Railfuture Lincolnshire magazineLincolnshire Branch members receive three copies a year of our local magazine, Rail Lincs, which keeps you up to date with local rail news and issues.
Rail Lincs Issue 60, June 2011 pdf 219kb
Rail Lincs Issue 61, October 2011 pdf 331kb
Rail Lincs Issue 62, February 2012 pdf 284kb
Rail Lincs Issue 63, June 2012 pdf 294kb
Rail Lincs Issue 64, October 2012 pdf 4.5mb
Rail Lincs Issue 65, February 2013 pdf 190kb
Rail Lincs Issue 66, June 2013 pdf 497kb
Rail Lincs Issue 67, October 2013 pdf 299kb
Rail Lincs Issue 68, February 2014 pdf 5.98mb
MediaThe chairman of Railfuture Lincolnshire is: David Harby 6 Carral Close, Lincoln, LN5 9BD. Tel: 01522 874513
For urgent media enquiries only, please contact david.harby at railfuture.org.uk tel: 07913 884815 or phil.mason at railfuture.org.uk tel: 01476 405959
EventsEvents and key dates for rail campaigners
Lincolnshire rail user groupsRail user groups in Lincolnshire are shown on Railfuture's Regional List of Rail User Groups. The Regional List can be downloaded in PDF format here.
Please email david.harby at railfuture.org.uk if you have any questions or comments about issues in the Lincolnshire area.
Railfuture - The independent campaign for a better passenger and freight rail network
We need you - Join us!
Please go to the Join page to become a member of Railfuture.
Railfuture is the campaigning name for the Railway Development Society Ltd, a company limited by guarantee. Registered in England and Wales No 5011634. Registered office: 24 Chedworth Place, Tattingstone, Suffolk IP9 2ND.


text:
Greetinghub.com ranks
#15,061,744 in the world and generates
141 Page views for daily.
FreeWebsiteReport estimates Greetinghub.com for a valuation of
$310 USD for it's visitor traffic that has the potential for CPC and Display-based advertising.
This traffic data suggests the Advertisers with a Traffic Acquisition Cost (TAC) of
$0.42 for daily and
$12.73 for monthly to spend on advertisements with Greetinghub.com. Greetinghub.com's page load time for
90th percentile measures at 1 sec. Greetinghub.com receives most of it's
organic referrals traffic from 14 websites around the world. Greetinghub.com servers are located in the Canada.
|Time Average
|Site Rank
|View Rank
|Views Per-User
3 Month
1 Month
Greeting Hub
Includes flowers, roses, butterflies, fairies, angels, and hotrods.
E-mail E-greetings
Google Safe Browsing - Safe website. Clean from Viruses, Malicious Worms, Adwares, Trojans, Spywares and Suspicious Phishing Attacks.
|DMOZ Name
|DMOZ Path
83 Timberwolf Cres, WoodBridge, ON - L4H 2W1, Canada. Phone: +1 416 636 2224, Fax: +1 905 303 6454 Email: shughes[AT]sudio.com


text:
Catheter Passport coming soon
King's College Hospital and Guy's and St Thomas' Hospital, including community services, are launching My Catheter Passport next week to improve care for people with catheters.
The Passport is a patient document full of useful information and key contact details for people with catheters, to empower them to live as independently as possible with their catheters, and know what services can to support them.
It also allows the sharing of patient catheter care plans between health and social care professionals in hospital and the community, ensuring there is an up-to-date record that is easily accessible.
During the week commencing 20 July, My Catheter Passport is being rolled-out across general practice, King's College Hospital, Guy's and St Thomas' Hospital including community services.
Adrian Hopper, Consultant Geriatrician at Guy's and St Thomas' NHS Foundation Trust, said: "The Passport will really help improve communication between all the different health and social care professionals involved in catheter care. This has already been evident during testing."
My Catheter Passport was developed by people with catheter experience and colleagues from King's College Hospital, Guy's and St Thomas' Hospital and general practice.
Adrian went on to say: "It's fantastic that we had the opportunity to co-design the Passport with people with catheters and health and social care professionals."
This patient-owned document should be with patients throughout their care and be used to keep a record of catheter changes or issues.
My Catheter Passport will be given to patients when they are discharged from hospital and those currently receiving care in the community.
You can view My Catheter Passport here.


text:
GraphicRiver Diving Signage Roll-Up Banner Template Vol.2 8989565
Category: Print Template | Comment: ( 0 )
GraphicRiver Diving Signage Roll-Up Banner Template Vol.2 8989565
Print Template \ Signage
Signage \ Roll \ Diving \ River \ Rollup \ School \ University \ Water \ Swiming \ Swim
Print Template - Diving Signage Roll-Up Banner Template Vol.2 8989565 by omar_almudaries @ GraphicRiver
Print Template \ Signage
Graphics Files Included: Photoshop PSD; Layered: Yes; Minimum Adobe CS Version: CS; Print Dimensions: 30x70.
Signage Roll-Up Banner Description.
Diving Signage Roll-Up Banner Template Vol.2 was designed for business, it's professional and eye catching. Attract people to your business with these beautiful Outdoor Banners!!!
Signage Roll-Up Banner Feature.
- Fully Layered PSD files
- Easy Customizable and Editable
- 30" x 70" (with 1.00 inch bleeds)
- CMYK Colors
- 150 DPI resolution
- Print Ready Format
- Only Free Fonts Used: Font.txt with download links.
Font Used.
- www.fontsquirrel.com/fonts/lato
- www.fontsquirrel.com/fonts/economica
- www.fontsquirrel.com/fonts/DejaVu-Sans
For any help regarding this file, please feel free to contact me through my profile page and I'll be glad to offer support. If you have a moment, please rate this item, I'll appreciate it very much!
Please Don't underestimate the power of the stars.
Thank you
Omar Waleed
Travel Gift Voucher Card Template Vol.13; Construction Advertising Bundle Vol.3; Bakery Poster Template; Diving Billboard Template Vol2; Company Brochure Bundle Vol.1; Corporate Business Flyer Vol.13; Corporate Brochure Tri-Fold Template Vol.13.
Keywords: advertisements, billboard, blue, business, cafe, coffee shop, diving, diving signage, energy, flyer, food, institute, ocean, restaurant, river, roll up, roll-up, rollup, school, signage, sweet, swim, swiming, university, water.


text:
05/05/04 04-35
San Francisco Police Chief Heather Fong will join hundreds of San Francisco school children aged five through 12 for a Chief's Day at the Movies to see the IMAX presentation of Disney's "Sacred Planet" on Saturday, May 8 at Loews Theaters in the Sony Metreon, Fourth and Mission streets. The day will begin at 9:00 A.M. with the serving of a cake in honor of Loews Theaters' 100th anniversary. The movie will follow at about 9:45 A.M.
After the movie, at about 11:00 A.M., everyone will board busses to travel to Crissy
Field inside the Presidio for a hike conducted by the National Park Service through this historic area. The outing will conclude about 3:00 P.M.
For more information, please contact:
Officer Brenda Rodgers


text:
Britain's supermarkets step up to save forestsOctober 2015
Asda has become the latest grocer to sign up to WWF's Save Forests campaign, completing the line-up of major supermarkets lending their support, all pledging to ensure their timber and wood based products will be from sustainable sources by 2020.
Now, all of the 'Big Four' supermarkets – controlling over 70% of the grocery market - have signed up to the campaign alongside Waitrose and M&S. The campaign is calling for loopholes in current legislation that allow illegally sourced or unsustainable wood to be legally imported and sold in the UK to be closed.
Signing up to the pledge means they will ensure all their own brand products and materials used will be from sustainable sources. It is also hoped that the supermarkets will be engaging with brands on sustainability of their own products, helping to shape a new market place based on sustainable supply instead of short-term gain.
It is believed that further impacts of the supermarkets making the pledge to buy sustainable timber and timber products by 2020 will be a decrease in the amount of illegal and timber products coming into the UK markets.
A further impact will be that consumers can be safe in knowing that they are shopping at a responsible company that is choosing to ensure it is not contributing to illegal or unsustainable deforestation around the world. Over half the products sold by supermarkets are own brand which is where they can exercise most influence.
WWF-UK's Julia Young, Manager of the Global Forest and Trade Network in the UK, said "Committing to WWF's forests campaign and ensuring their businesses are not contributing to illegally sourced or unsustainable timber is a powerful and important step that will have a huge impact on some of the world's remaining natural forests.
"If the remaining few grocery chains made the pledge they could have an incredible impact in the UK and beyond, helping save the habitats of some of the most endangered species."
Already a member? click here to login
UK & NI Ireland | sustainable forestry


text:
"Well, I could go with two different answers," Chenier told the Wizards Web site, when asked for an explanation. "One, I was bored to death and just started shaving one day and just never stopped. And that's probably the truth. The other is I wanted to do something different. So just cut it off and I realized that I'm getting attention from it, so it's a good thing."
Chenier, as you no doubt already guessed, gave this interview after throwing out the first pitch at a Bethesda Big Train game. Video of his pitch is below. Better than John Wall, worse than Jordan Zimmermann.


text:
We are well capitalised, highly experienced, flexible, innovative and responsive - the ideal collaborative partner for your dispute resolution funding requirements.
Sir Andrew Smith QC was called to the Bar in 1974 and was appointed Queen's Counsel in 1990.
He retired in October 2016 from being a full-time Judge of the High Court. Sir Andrew will continue as a Deputy High Court Judge, and will sit as an arbitrator. He has been appointed as a Judge to Abu Dhabi Global Market Courts (ADGM Courts), he sits as a Chairman of the Disciplinary Panel of the London Metal Exchange and he is also a member of the Investment Committee at Vannin Capital.
Judicial History
Sir Andrew Smith was appointed to the Queen's Bench Division of the High Court of England and Wales in July 2000, and a knighthood was conferred on him. Shortly after his appointment he was nominated by the Lord Chancellor to sit in the Admiralty Court and in the Commercial Court. He has sat in those two courts, in the Queen's Bench and Chancery Divisions of the High Court, the Crown Courts and in the Criminal Division of the Court of Appeal. Between 2003 and 2006 he was Presiding Judge of the North Eastern Circuit, with responsibilities for all the courts in the Yorkshire, Humberside and the Tyne and Weir areas of England. His skills and experience as a commercial judge were recognised when in 2008 he was appointed to be the Judge in Charge of the Commercial Court for an extended period, in order that he should supervise reforms to the Court's new procedures that were introduced following the Report on Procedures for Long Trials. He retired in 2016 after service in the full-time judiciary of over 16 years.
Legal History
He joined the Middle Temple, and was called to the Bar of England and Wales in 1974. He was elected a Master of the Bench in 1999. The focus of his practice was commercial work, but more generally his practice comprised common law and chancery litigation and advisory work, and work at the Parliamentary Bar. In 1990 he was appointed a Queen's Counsel. While practising at the Bar, he served in a judicial capacity as a Recorder and as an Assistant Electoral Commissioner, and also sat as an arbitrator over commercial and other business disputes.


text: I have had an MT52 for three years now and run it almost every day. I have 1200 hrs on the machine and will tell you it is the best investment I have ever made. I can answer any questions you have about it. I will try to summarize: 1) Wheeled Platform - It is annoying at times, especially when trenching. They do make a platform that does not have the wheel and you just stand on. It's not a big deal to take it off when necessary though. 2) Attachment Plate - Bobcat makes one to adapt to the toro attachments, it cost me about $300 a couple years ago. A sidenote, the attachment plate does not adapt to the toro soil cultivator. The angle of the hydraulic attachments and distance to the machine does not work unless you have longer than normal hydraulic hoses. There is only one place I can rent this from and it doesn't work. 3) Power - People will go on and on about which machine has more power, etc., etc. The bottom line is the Mt52 will handle anything you need it to. I can trench 24" deep in red clay and run a 36" auger with it. The machine is properly powered. Also, consider the fuel savings with a smaller enigne. I can run about 6-8 hrs on a 6 gallon tank. 4) Tracks - I get about 400-500hrs out of them. But we do a lot of work on concrete and asphalt as far as picking up soil and gravel. If you mainly work in the soil, you should get 800-1000 hrs out of your tracks. 5) Grease - Keep it greased daily! I like the idea of being able to grease the machine vs. the ones that you cannot. You have control over it. I use to run mowers that had grease points and ones that did not. The mowers with grease points always outlasted the ones that did not as long as you grease them properly. 6) Dealer Support - Incredibly important. My dealer is outstanding and has me back on the jobsite witihin a day. I have only had to take the machine in a couple times, recently for a new wiring harness. But they had me ready the next day. Downtime kills you, so this is huge. Let me know if you have any other questions about the machine.


text:
Orijen Freeze Dried Adult Dog
Orijen Freeze Dried Adult Dog
EVOLVED AS CARNIVORES, ALL DOGS ARE BIOLOGICALLY ADAPTED TO THRIVE ON A VARIED DIET OF FRESH WHOLE MEATS, WITH SMALL AMOUNTS OF FRESH FRUITS, BERRIES AND GRASSES. That's why ORIJEN ADULT DOG is loaded with meat ingredients (90%), including a Biologically Appropriate™ symphony of cage-free chicken, turkey and nest-laid eggs from local farms, plus wild-caught herring and flounder from North Vancouver Island, all delivered to our kitchen FRESH, where they're flash frozen and gently freeze-dried to lock in their goodness and taste.
Brimming with goodness to nourish your dog completely, ORIJEN ADULT DOG features poultry and fish in authentic Whole Prey ratios, including richly nourishing liver and heart, marrow and cartilage which supply essential vitamins and minerals in natural form, dramatically reducing the need for synthetic ingredients in ORIJEN foods. Prepared from Canada's very best and freshest ingredients in our very own freeze-dry kitchens, ORIJEN ADULT DOG is guaranteed to keep your dog happy, healthy and strong ? read our ingredients and we think you?ll agree!
FRESH REGIONAL INGREDIENTS: Chicken (ground with bone)*, turkey (ground with bone)*, whole herring*, chicken liver*, chicken heart*, whole eggs*, spinach greens*, pea fiber, turkey liver*, turkey heart*, whole flounder*, ground sunflower seeds, pumpkin*, Butternut Squash*, Imperator carrots*, cranberries*, blackberries*, blueberries*, Red Delicious apples*, Bartlett pears*, Red Heart plums*, Tilton apricots*, brown kelp*, mixed tocopherols, chicory root, dandelion root, summer savory, peppermint leaf*, ginger root*. *FRESH AND PRESERVATIVE-FREE SUPPLEMENTS Zinc proteinate, iron proteinate, copper proteinate, manganese proteinate.
ORIJEN FEATURES POULTRY AND FISH IN AUTHENTIC WHOLE PREY RATIOS, INCLUDING RICHLY NOURISHING LIVER AND HEART, MARROW AND CARTILAGE WHICH SUPPLY NUTRIENTS IN NATURAL FORM. NO SYNTHETIC PROTEIN. Made with 90% fresh poultry, eggs and fish, ORIJEN's Biologically Appropriate protein level replicates the natural canine diet. ALL PROTEINS ARE 100% NATURAL. NO SYNTHETICS. NO ADDED FATAll fats in ORIJEN freeze-dry foods are naturally occurring in the high inclusions of fresh poultry, fish and egg ingredients. ALL FATS ARE 100% NATURAL. NO SYNTHETICS. LOW GLYCEMIC Made with 90% meat, ORIJEN freeze-dry foods contain very few carbohydrates, from fresh fruits and vegetables only, producing an extremely low Glycemic Load. NATURAL SOURCE GLUCOSAMINE & CHONDROITIN ORIJEN's fresh poultry, meats and fish provide a rich and natural source of glucosamine and chondroitin. 100% NATURAL. NO SYNTHETICS.
GUARANTEED ANALYSIS: Crude protein 36% (min.) Crude fat 35% (min.) Crude fiber 5% (max.) Moisture 4% (max.) Calcium 1.6% (min.) Phosphorus 1.3% (min.) Omega-6 5.5% (min.) Omega-3 1.0% (min.) DHA 0.2% (min.) EPA 0.2% (min.) Glucosamine 800mg/kg (min.) Chondroitin 800mg/kg (min.)
RECONSTITUTED ANALYSIS: Crude protein 13% (min.) Crude fat 13% (min.) Crude fiber 2% (max.) Moisture 65% (max.) Calcium 0.6% (min.) Phosphorus 0.05% (min.) Omega-6 2% (min.) Omega-3 0.4% (min.) DHA 0.07% (min.) EPA 0.07% (min.) Glucosamine 292 mg/kg (min) Chondroitin 292 mg/kg (min).


text:
Dear Wordtree
What a great post. I would have never have connected the writing of case studies with Top Gear, but you're absolutely right. We have to produce case studies and e-newsletters, but sometimes you think it would be more exciting for the recipient to read about watching paint dry. Now, with your approach (and with JC on my shoulder) — and I agree it won't work for every client — I think that it will add real impact and will encourage the reader to want to, well, read.
This will be music to my boys' ears, who both love the show and will be very impressed if they think it can help to improve your writing skills.
I only stumbled across your website by chance but it is one that I will bookmark and return to.
Best wishes
Simon Turton


text:
Ross Ulbricht, known as Dread Pirate Roberts (31 years old), will be spending life in prison without parole. The list of charges includes conspiracy to commit drug trafficking, money laundering and computer hacking.
He is the founder of the site called Silk Road, which has been found to be complicit with the sale of approximately $200 million worth of drugs. Ulbricht himself never touched the drugs which were bought with currency that did not physically exist, through a portion of the internet that many go through their entire lives without experiencing. It is regarded as one of the harshest sentences given to a person for online/non-physical activities.
A new method of business
The Silk Road operated in what is called the 'Deep Web'; the shadier side of the internet that features a wide variety of illegal and banned items for sale. Users navigate through it using Tor browsers, which hid their identities and allowed them to navigate these deep websites without the fear of law enforcement tracing their IP addresses.
Silk Road, established in February 2011, was a platform in which users could buy and sell drugs online. It was an eBay for ecstasy, an Amazon for amphetamines, and a bazaar that used Bitcoin; an online currency praised for its decentralized nature.
In addition to drugs, Silk Road also sold cyanide, which is believed to have been used in at least five attempted murders. Ulbricht himself was aware of this, and even requested an image of a murder from a user. The site ran like any other specializing in the sale of goods, even having reviews for sellers. It was on this site that Ulbricht was known as Captain Dread Roberts, a reference to the movie The Princess Bride.
As with most businesses, the creator was protective and proud: "I'm running a god-damn multi-million-dollar criminal enterprise", Ulbricht said in a message obtained by the FBI.
Closing the online black market
Silk Road was shut down by authorities in 2013 after multiple sting operations. The charges against him added up to a minimum sentence of 20 years in prison. For every transaction, Ulbricht made money in the form of commission, and he kept a journal detailing his accounts and the creation of the site.
In court, his lawyer Joshua Dratel made a specific case: Ulbricht wasn't really Captain Dread Roberts. Soon after the creation of Silk Road, Ulbricht handed the website to someone else and then the site was returned in order to make him the 'fall guy'. This turned out to be false when persecutors brought Ulbricht's servers as evidence. Dratel also tried to rationalize Silk Road, claiming that it helped reduce problems associated with drug trafficking, a statement that Judge Forrest strongly disagreed with.
After the jury looked at statements and evidence, they declared Ulbricht guilty on all counts. "No drug dealer from the Bronx has ever made this argument to the court. It's a privileged argument and it's an argument made by one of the privileged," Judge Forrest said before giving Ulbricht his life sentence.
The aftermath
"It reminded me of when I had people close to me die," said Lyn Ulbricht, the mother of Ross Ulbricht. She believes that her son is a political prisoner, a reference to the supporters of Ulbricht stating that the life sentence was given due to the failure of the war on drugs. Supporters have also pinned his life sentence on the government's fear of technology and the unknown quantities of the internet.
Whether a victim of his own crimes or the frustrations of the government, Ulbricht will have a lifetime incarcerated to reflect on his actions. In a letter to Judge Forrest a week before his court appearance, he stated: "In creating Silk Road, I ruined my life and destroyed my future."
– Aitana Yvette Mallari, Correspondent (Tech)


text:
MLB Free Agency 2013: 5 Under-the-Radar PlayersOctober 10, 2012
MLB Free Agency 2013: 5 Under-the-Radar Players
Postseason baseball is in full swing, but it seems like a lot of attention has been directed toward talking about players who will be free agents.
Twenty-two of baseball's 30 teams have already made family vacation and golfing plans, but MLB front offices are already evaluating free agents in an effort to improve their teams.
Unsung heroes plucked from the scrap heap often play huge roles and deliver the most memorable moments in the postseason.
Josh Hamilton, B.J. Upton, David Ortiz, Dan Haren, Michael Bourn and Brian McCann are just some of the big names possibly heading for big contracts with other clubs in the offseason. These big names are involved in discussions almost every day.
Teams that really do their homework this offseason will target players who give them good production at a reasonable price. Clubs that get these guys will save money and have more to spend on re-signing players and acquiring players fit to help the club down the road.
As baseball's postseason rolls on, let's take a look at some affordable under-the-radar players who can help teams reach a World Series in 2013.
Luke Scott
The 34-year-old has been injury-riddled these past two seasons, playing in only 160 games for the Baltimore Orioles and Tampa Bay Rays.
When healthy, the designated hitter, who can play a little first base as well, swings a powerful bat. Despite the injuries, Scott managed to hit 14 homers with 55 RBI in 96 games for the Rays in 2012.
Scott is the second-youngest DH on the market at age 34. Fellow designated hitters David Ortiz, Jim Thome, Travis Hafner, and Raul Ibanez are all free agents and more advanced in age, so teams should be more willing to give Scott a look and offer him a contact because he may have four or five more years of productive baseball in his future.
It appears unlikely the Rays will pick up Scott's $6 million option for 2013. The Rays seem intent on shaking up an offense that hit just .240 in 2012
Scott posted three consecutive 20-plus home run seasons with Baltimore from 2008-10, so it's not unrealistic to think that production is possible if he can stay healthy.
Shane Victorino
Victorino was sent to the Dodgers in a trade right before the deadline, ending his eight-year run in Philadelphia as a member of the Phillies.
The Flyin' Hawaiian hit .245 with two homers, 15 RBI, and 15 stolen bases in 53 games with his new club. It appears that he will be the odd man out for the Dodgers, who will probably go with Matt Kemp, Andre Ethier and Carl Crawford in the outfield.
The versatile 31-year-old center fielder should not be taken lightly on the open market and will surely draw interest from several teams.
When asked if could still make an impact as an everyday player, Victorino told Los Angeles Times' Steve Dilbeck and other reporters he could.
"Absolutely," he said. "I'm not taking a back seat to nobody. Not in a negative way am I saying that. I still feel like I can play every day and that's my goal. I don't know who came up with the mindset that all of a sudden that I'm not an everyday player."
The two-time All-Star and three-time Gold Glove Award Winner still has a lot left to give, and teams would be wise to bring him aboard without breaking the bank.
With 46 games of postseason experience, Victorino would provide leadership for a young team on the rise.
Brandon McCarthy
McCarthy's season took a frightening turn in early September when he was hit in the head with a line drive in a game. McCarthy went to the hospital and needed brain surgery to relieve pressure on his brain.
McCarthy was released from the hospital on Sept. 11, less than a week after undergoing surgery. As postseason play began, he even told manager Bob Melvin he could possibly help the team in the playoffs.
The A's and Detroit Tigers are going to Game 5, so both teams are fighting for their lives, but it doesn't seem like they will take a chance in putting McCarthy out on the mound.
McCarthy will be a free agent this offseason and sure to draw interest. Before the injury, McCarthy went 8-6 with a 3.24 ERA in 18 starts for Oakland. Last year, he went 9-9 with a 3.32 ERA.
Teams unwilling to spend big money chasing a Zack Greinke or Dan Haren can get similar production from McCarthy at a better price.
If McCarthy can stay healthy for an entire season, he could be a good No. 3 starter with a 15-win season possible.
Angel Pagan
The 31-year-old center fielder can be a real asset to teams looking for speed and steady production at the top of the lineup.
Pagan's strong play began in 2008, when he hit .306 with 14 stolen bases in 88 games for the Mets. In his first full season in 2009, he hit .290 with 11 homers, 69 RBI, and 37 stolen bases. Before the 2012 season, he was traded to the Giants.
Pagan's numbers this year were not flashy (.288, eight HR, 56 RBI, 29 SB), but most teams would like to have the consistency the switch-hitter provides.
Pagan's age shouldn't be a concern because he only has three full years of baseball under his belt.
Jeff Keppinger
Keppinger was the exception for a Tampa Bay offense that struggled at the plate for much of the year.
The utility man hit a sparkling .325 with nine homers and 40 RBI in 115 games.
Teams should take notice of what Keppinger accomplished and consider adding a guy who played three positions, as well as DH in 2012. Keppinger is not a speed guy (12 SB in career), but his career .337 on-base percentage can serve a club desperate for guys with the versatility he possesses.
Keppinger rarely strikes out and would be a welcome member to any clubhouse in 2013.


text:
MP to stress uranium export opposition
Throsby MP Stephen Jones says he will vote against lifting Labor's current ban on exporting uranium to India at the party's conference next month.
Prime Minister Julia Gillard wants to change Labor's uranium exports policy, which only allows exporting it to signatories of the nuclear non-proliferation treaty.
She says selling uranium to India would strengthen Australia economically.
However, Labor left faction convener Stephen Jones has told ABC's 7.30, that he opposes all uranium exports and will be arguing against it at the conference.
"I'll be taking the concerns I've had for around 20 years on this and that is that we should not be adding to the stockpile of weapons-grade uranium throughout the world by exporting our uranium out of Australia," he said.
The secretary of the South Coast Labour Council, Arthur Rorris, shares the concerns expressed by Mr Jones.
Mr Rorris says the labour council has a long held position of opposing nuclear proliferation.
"The last thing we need is the proliferation of things which we have seen only this year to have such tragic consequences at Fukishima and that's just the peaceful use, let alone the other cycle of the nuclear industry which involves the nuclear arms industry," he said.
Topics: uranium-mining, trade, alp, wollongong-2500
First posted


text:
ideal for: huge outdoor events, large audiences, tour packages, national acts
Call for a quote.
Our most popular stage features a hydraulic fold. Minimal staffing is require.
1- Hydraulic Folding Platform Stage (35'W x 24'D x 42"H)
2- Speaker Wings (8'W x 6'D x 42"H up to 16' L)
1- Drum Riser (8'W x 8'D x 24"H)
1- Framed Vinyl Cover (35'W x 24'D)
1- Wind Screen Backdrop (35'W x 20'H)
Ideal for: festivals, fairs, rising stars, national acts and almost any other occasion.
Call for a quote.
Our mid-size stage also features a hydraulic set up. Minimal staffing with quick set up and tear down.
Dimensions: 24W'x15'Dx3'H
Ideal for: festivals, and inside a tent.
Call for a quote.
Our platform staging is our most versatile setup.
Platforms are placed together in 8 ft. segments.
Various shapes and sizes can be made.
Ideal for: small indoor events. graduation ceremonies, wedding receptions, etc.
Call for a quote.


text:
Loading in 2 Seconds...
Loading in 2 Seconds...
LPA Basic Project Development Training Britni Saunders LPA Training, Policy & Guidance, INDOT March 27, 2014. Getting Started- Federal Aid.
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
Britni Saunders
LPA Training, Policy & Guidance, INDOT
March 27, 2014
"Stewardship & Oversight"
"Funding: Funding Basics & Eligibility"
Failure to comply puts the LPA at risk of being required to refund a portion or all of the federal funds expended on the project.
Travis Kohl
Local Project Manager, Crawfordsville, INDOT
Joe Sheedy
Local Project Manager, Greenfield, INDOT
The Federal Highway Administration (FHWA) provides stewardship over the construction, maintenance and preservation of the Nation's highways, bridges and tunnels. FHWA also conducts research and provides technical assistance to state and local agencies in an effort to improve safety, mobility, and livability, and to encourage innovation
Jennifer Beck
Local Project Manager, Indianapolis, INDOT
*Please reference the attached contact sheet to see who fills these rolls for your district.
Mike Wink
Local Project Engineer, Crawfordsville, INDOT
"Project Delivery: A Process from Cradle to Grave"
Step 1: Define your project
Step 2: Apply for federal funding
Step 3: Receive notice of funding award
Step 4: Schedule the Early Coordination meeting with your district
Step 5: Select a consultant
Step 6: Design Submittals
Step 6A: NEPA Document
Step 6B: Right-Of-Way
Step 6C: Utility Coordination
Step 6D: Railroad Coordination
Step 7: Final Tracings
Step 8: Contract Letting
Step 9: Construction
Step 10: Project Closeout
AJ Wortkoetter
Local Project Engineer, Greenfield, INDOT
Susie Kemp
District Local Program Director, Crawfordsville, INDOT
Marcy Jeffers
Local Project Manager, Crawfordsville/Greenfield, INDOT


text:
Selected Highlights
- Business founded in 1997
- 2200 sq ft shop
- GS 15 Vinyl Cutter
- 30" Roland VP-300 Printer
- Envision 750 Vinyl Cutter
- Earned Commercial Art Degree
- No Job to Small or to Large
After earning a commercial art degree, he started looking for work in the graphics arts field. Brian worked in different jobs during that time, always doing some lettering on the side. He found that signwork took off a lot faster than finding work as a graphic artist. So in 1997 he started his own sign business. For almost 15 years he has been working in his home-based shop in Centre Hall, Pennsylvania, located in central part of the state, not too far from State College, Pennsylvania, the home of the Penn State University. His shop is a 34-by-64 ft. building with overhead doors at each end, situated on four acres


text:
TRUMP: The most powerful man of the free world talks about US healthcare. Trump brings clarity to the table and paints the picture he wishes to see for private/public healthcare system in the country. President of the United States outlines how time-taking and dawdling the prevalent healthcare provision process can be and hence promises to make the system efficient altogether. And "if it's not good, you're going out to private hospitals, public hospitals, and doctors."
What will health care look like under Donald Trump?
What were once just worrisome campaign promises have become credible threats following Donald Trump's presidential win. Among these is Trump's repeated insistence that one of his first moves in the White House would be to repeal the Affordable Care Act, informally known as Obamacare.
At the second presidential debate in October, Trump said, "Obamacare will never work. It is very bad, very bad health insurance. Far too expensive, and not only expensive for the person that has it, [but] unbelievably expensive for our country." He added, "We have to repeal it and replace it with something absolutely much less expensive."
Trump doubled down on this hardline stance just a week before Election Day, reassuring his supporters that a Republican Congress would help him achieve this goal.
"When we win on Nov. 8 and elect a Republican Congress, we will be able to immediately repeal and replace Obamacare," Trump said at a Pennsylvania rally. "Have to do it. I will ask Congress to convene a special session so we can repeal and replace." Continue Reading
Trump victory sets off healthcare stampede
The day after Donald Trump's stunning victory in the presidential election, a record number of Americans signed up for Obamacare health coverage, and women began scrambling for long-term contraception.
On Wednesday, more than 100,000 people selected plans through HealthCare.gov during this year's signup period, which began November 1. "Best day yet this Open Enrollment," said Secretary of Health and Human Services Sylvia Mathews Burwell. In her tweet, she added the hashtag 'GetCovered.'
Meanwhile, women's health advocates are urging women to quickly get an intrauterine device, which can provide safe, highly reliable birth control for up to 10 years—well past a presidential term or two.
The frantic movements are likely out of fear and speculation about how President-elect Trump will alter the country's expensive and complicated healthcare system during his time in office. Though short on details within his plan, Trump said he intends to repeal Obamacare and replace it with Health Savings Accounts—something fellow Republicans have supported. And both Trump and his running mate, Mike Pence, campaigned on pro-life platforms. Though Trump has in the past stated that he's "very pro-choice," he said during this election that women should be punished for having an abortion. Pence has had a consistent record of limiting access to abortion and restricting women's healthcare. Read more
What Will Women's Health Care Look Like Now?
Many of us are still processing the results of the election, but it's worth looking to the future to see what women's health care would look like in a Trump administration. The short answer: It's not going to be good.
Donald Trump, president-elect, says he wants to repeal and replace the Affordable Care Act, which says insurers cannot deny coverage if you have a preexisting condition, that young adults can stay on their parent's insurance until 26, and annual well-woman gyno visits and birth control must be covered without a copay. Even if Trumpcare does include these preventive services, as medical experts recommend, about 22 million people could lose their health insurance after a two-year, post-repeal transition period. These would mostly be people who have insurance through Medicaid or the insurance exchanges — in other words, low-income people. Continue Reading
Trump Can Kill Obamacare With Or Without Help From Congress
President-elect Donald Trump has promised over and over in recent months that he will repeal and replace the Affordable Care Act, also called Obamacare, when he reaches the White House.
"Obamacare is a disaster. You know it. We all know it," Trump said at a debate last month. "We have to repeal it and replace it with something absolutely much less expensive."


text:
A Blooming Event!
Our Toole County Garden Club has a meeting scheduled for THIS Monday night here in Shelby. Garden Club members will be getting together over at 334 12th Avenue South. You don't have to have a "Green Thumb" to attend either! Monday's night's meeting starts promptly at 6 o'clock. How DOES your garden grow? As ol' Bob used to say, "Can you dig it."


text:
STMicroelectronics announced a new TV System-on-Chip (SoC) incorporating an integrated 3D graphics accelerator, enabling next-generation Internet TV services, user interfaces and casual gaming.
For more information visit: www.st.com
Unedited press release follows:
STMicroelectronics Reaches Ultimate Dimension in TV with New High-Performance Digital TV System-on-Chip and Video-Enhancement IC for Best-in-Class Motion-Compensated 3DTV and 3D Graphics
High-performance full-featured SoCs deliver compelling new entertainment and web-based services while slashing overall TV power consumption, and facilitating new business models for the TV industry
GENEVA, Sept. 3 — STMicroelectronics (NYSE: STM), one of the world's largest semiconductor companies and a leader in chips for set-top boxes and digital TVs, today announced a new TV System-on-Chip (SoC) offering the first-of-its-kind integrated 3D graphics accelerator (OpenGL-ES 2.0 and OpenVG 1.1 compliant), enabling next-generation Internet TV services, exciting user interfaces and casual gaming.
ST's new FLI7540, representing the 'Freeman Ultra' line of products, powers high-performance TVs that demand exceptional video, audio, and user-interface capabilities. The FLI7540 delivers exceptionally high performance (1700+ DMIPS CPU with 256 kbytes of Level 2 cache), strong security dedicated for advanced middleware/Internet TV applications, and is compatible with worldwide digital terrestrial television (DTT) standards.
ST has also introduced a new high-quality Faroudja™ video-enhancement IC that dramatically reduces TV power consumption and boosts video quality for LED TVs while offering best-in-class experience for 2D/3DTV. The FLI2520 'Diamond' video-enhancement IC delivers the industry's first single-chip 2D/3D@200/240Hz with advanced MCTi(1) motion judder and blur reduction, plus 240Hz LED backlight adaptive local dimming and 480Hz backlight scanning for motion-blur reduction.
The FLI2520 is also the first TV IC offering the royalty-free VESA interconnect standard iDP (internal DisplayPort) output to the panel timing controller. For TV set and panel manufacturers, iDP substantially reduces BOM cost and system complexity, in comparison to alternative approaches.
"Our TV customers demand powerful solutions to meet the requirements in next-generation products to support extensive processing for the enhanced Internet TV and 3D video experiences," said Luigi Mantellassi, General Manager of ST's TV and Monitor Division. "The Freeman and Diamond family of TV products offer TV manufactures a solid foundation to quickly design a portfolio of compatible, high-value TV models with compelling step-up features and price points. In addition, Freeman's Internet TV, security engine, 3D graphics, and flexible software framework enable exciting new business models for both TV manufacturers and retailers, while consumers enjoy unprecedented, instant access to large vaults of content."
The BOM cost-efficient combination of FLI7540 and FLI2520 results in a unique and uncompromised range of key technologies:
* Wealth of content access and new business models with Internet TV
* Rich and innovative user interfaces with OpenGL ES 2.0 3D graphics
* Silky smooth film- and video-motion compensation with 200/240Hz Faroudja MCTi
* Best quality, motion-compensated 3DTV@200/40Hz. Also 2D->3D conversion.
* Substantial power reduction and enhanced contrast ratio with LED backlight adaptive local dimming
The FLI7540 is software compatible with other products in the Freeman product line, and is the culmination of the integration of world-class technologies from ST's industry-leading set-top-box chips and the Emmy® Award winning Faroudja video-processing technologies.
(1) Motion-Corrected Temporal Interpolation (MCTi) is an ST-proprietary technology that smooths out fast-moving 3D and 2D images
Availability and Pricing
The FLI7540 and FLI2520 and associated platforms are now sampling to qualified customers. Pricing is available to OEMs, upon request. Both products will be demonstrated at ST's private suite at IFA 2010 in Berlin.
About STMicroelectronics
STMicroelectronics is a global leader serving customers across the spectrum of electronics applications with innovative semiconductor solutions. ST aims to be the undisputed leader in multimedia convergence and power applications leveraging its vast array of technologies, design expertise and combination of intellectual property portfolio, strategic partnerships and manufacturing strength. In 2009, the Company's net revenues were $8.51 billion. Further information on ST can be found at www.st.com.


text: Conal Elliott wrote: > Pare the Haddock markup language down to > very few markup directives, say just 'foo' and > "Foo.Bar". Other critical ones: -- | This shows which syntax this text describes. -- ^ So does this. Less critical, but usually not provided by general markup languages: -- $doc A movable documentation chunk. If Haddock itself does not parse any other markup, we must make sure to use markup that does not lock up its information. It should be something we have a parser for, or something that has good tools for turning it into some robust machine-readable format in a lossless way. The reason is that I may want to use a bit of Haskell in a much larger project that uses some other markup system for its API documentation. So, for example, if I want to integrate the output into a larger DITA project, there should be an easy way to do that. Or Doxygen, or whatever else. Then Haddock would need to have some way of outputting its own information nicely, with embedded chunks of markup. You would read that, passing each chunk of markup through its parser. Truth is, I don't see any such parser for "markdown". Do you know of one? Maybe we would have to write one. I think that improving the markup capabilities of Haddock is a minor issue. The main value of Haddock is its API metadata. Haddock currently keeps most of that in its bellly, using it secretly to create its own presentation output. The biggest improvement would be getting meaningful machine-readable output. Your idea of abstracting out the markup could actually make that easier, if we keep that goal in mind as well. Thanks, Yitz


text:
MOVIE SYNOPSIS [ General Audiences ] Movie of Jodi Binstock. Introduced in cinemas in 2013, with production teams of USA. You can watch A Snow Globe Christmas online on TV cable or theaters with original audio in English at different dates. This film premiered in theaters in 2013.
Rating: 5 by 250 users./
Runtime: 89 minutes
Alicia Witt, Donald Faison, Christina Milian, Trevor Donovan, Art LaFleur, Damoni Burkhardt, Hayden Faraday, Francia Raisa, Logan Binstock, Jackie Moore, Amy Ryder, Alex Ball, Brody Hutzler, Diahnna Nicole Baxter, Henry 'Chopper' Platt and Tyler Griffin.
Drama, Family.
89-minute film (full movie) directed by Jodi Binstock.
The original audio of A Snow Globe Christmas has dialogues in Dolby Digital, it was produced in USA.
It premiered in cinemas or television in 2013.
Screenplay written by Naomi L. Selfman and Delondra Williams.
Warren Yeager.
Paul Bales, Maximilian Elfeldt, David L. Garber, David Michael Latt, Cody Peck and David Rimawi.
This film was produced and / or financed by 2 x 2 Productions, Asylum and The.
Composed by Chris Ridenhour.
Lifetime Movie Network.
Without commercial breaks, the full movie A Snow Globe Christmas has a duration of 89 minutes; the official trailer can be watched in streaming on the Internet. You can watch this full movie free in EnglishDolby Digital in movie TV channels, renting the DVD or with VoD services (Video On Demand player, Hulu) and PPV (Pay Per View, Netflix).
See the page of this full movie, A Snow Globe Christmas in FULLTV Movies.