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Banque Nationale de Genes
Banque Nationale de Genes
Debbabi O.S.,Banque Nationale de Genes |
Bouhlal R.,Institute National Of Recherches Agronomiques |
Abdelaali N.,Institute National Of Recherches Agronomiques |
Mnasri S.,Banque Nationale de Genes |
Mars M.,University of Sousse
International Journal of Fruit Science | Year: 2013
The aim of this study was to characterize the major orange cultivars from Tunisia and to study the genetic diversity within this fruit tree species. This work was conducted in the framework of the activities of the fruit tree network in the Tunisian National Gene Bank. The pomological diversity of 28 Tunisian sweet orange cultivars was analyzed based on 18 qualitative and quantitative traits. Different regions of Tunisia, where orange cultivation is prominent, were investigated. Principal components analysis conducted on quantitative traits showed an important degree of variability of about 94% for the three first principal components. Factorial analysis of correspondence was conducted for qualitative data and it showed 69% of the total diversity for the three first factors. A dendrogram was constructed based on average distances. Results showed that the geographic origin was not the determinant criteria for cultivar segregation. © 2013 Copyright Taylor and Francis Group, LLC.
Nasri N.,University of Tunis |
Nasri N.,Institute National Of Recherches En Genie Rural Eaux Et Forets |
Elfalleh W.,Institute des Regions Arides |
Tlili N.,University of Tunis |
And 4 more authors.
Lipids in Health and Disease | Year: 2012
Background: Oilseed samples from four Acacia species (A. cyclops, A. ligulata, A. salicina and A. cyanophylla) were analyzed in order to evaluate the potential nutritional value of their unexploited seeds. Methods: Samples were collected from different Tunisian geographic locations. Seed oils were extracted and carotenoids, tocopherols and sterols were analyzed using chromatographic methods. Results: The studied Acacia seeds seem to be quite rich in lipids (from 6% to 12%). All Acacia species contain mainly the xanthophylls zeaxanthin and lutein compounds: from ca. 38 mg.kg-1 of total lipids (A. cyclops) to ca. 113 mg.kg-1 of total lipids (A. cyanophylla). Total tocopherols varied from ca. 221 mg.kg-1 of total lipids (A. cyclops) to ca. 808 mg.kg-1 of total lipids (A. ligulata). Sterols are highly present and their contents ranged between ca. 7 g. kg-1 of total lipids (A. salicina) and 11 g. kg-1 of total lipids (A. cyclops). Conclusion: This study highlights that these unexploited seeds might have a potential nutritional value and encourages researchers to more explore and find developments for these plants for healthy purposes. © 2012 Nasri et al.; licensee BioMed Central Ltd.
Mezghani N.,Banque Nationale de Genes |
Zaouali I.,Banque Nationale de Genes |
Amri W.B.,Banque Nationale de Genes |
Rouz S.,Institute Superieur Agronomique Of Mogran |
And 6 more authors.
Genetic Resources and Crop Evolution | Year: 2014
Fruits present major morphological characters used to define genera and species within the Apiaceae. Northern Africa represents a major center of diversity of Daucus, with Tunisia containing at least 12 species and six subspecies. We assessed 14 mature fruit characters from the Daucus L. germplasm collection at the National Gene Bank of Tunisia. Quantification of variability for each character was investigated using the standardized Shannon-Weaver diversity index (H′). Diversity was established by factorial analysis of correspondence and cluster analysis. The computing H′ index ranged from 0.31 for stylopodium shape to a maximum of 0.81 for spine shape. A mean diversity index for all traits recorded across all populations averaged 0.58 indicating existence of an important genetic diversity within the collection. Multivariate analysis of factorial correspondence and cluster analysis on morphological descriptors permitted the subdivision of the Daucus collection into five distinct groups including one single accession group, two groups with six accessions, one group of nine accessions and one large group with 81 accessions corresponding each one to a species among Daucus except the large group corresponding to D. carota and D. capillifolius. The grouping of populations did not reflect bioclimatic and geographic patterns, suggesting adaptation of populations to local environments. Of equal importance, our study shows the effectiveness of fruit characters alone to identify species in this collection of Daucus. © Springer Science+Business Media Dordrecht (outside the USA) 2013.
Sayar R.,National Agriculture Research Institute of Tunisia INRAT |
Bchini H.,Physiology Laboratory |
Mosbahi M.,Banque Nationale de Genes |
Ezzine M.,Physiology Laboratory
African Journal of Agricultural Research | Year: 2010
The present investigation has been performed to evaluate Durum wheat (Triticum durum Desf.) tolerance to osmotic stress at the water potentials of -0.2, -0.4, -0.6 and -0.8 MPa induced by polyethylene glycol PEG-8000 (polyethylene glycol 8000) or NaCI solutions at an early stage of plant growth. Each, on germination, emergence and early seedling growth, were investigated for two Durum wheat (Triticum durum Desf.) varieties differing in drought tolerance (BD290273 and Omrabia). Daily and final germination and emergence percentage, as well as germination and seedling emergence rate, and seedling fresh and dry weight were measured in the study under controlled conditions. Results showed those germination and emergence rates were delayed by both solutions in both varieties, with differences between genotypes among growth stages, given that Omrabia variety showed a higher germination and emergence rate than BD290273 genotype in NaCI but BD290273 was less affected by NaCI and PEG solutions at the emergence stage. Sodium chloride had a lesser effect on varieties in terms of germination and emergence rates, the final germination and the emergence percentage than did PEG-8000. This conclusively proves that the adverse effect of PEG on germination, emergence and early seedling growth was due to the osmotic effect rather than the specific ion. Seedling growth was reduced by both stresses. But NaCI usually caused less damage than PEG to Durum wheat seedlings, suggesting that NaCI and PEG acted through different mechanisms. This difference in cultivar's behaviour according to the growth conditions is discussed. It was concluded that inhibition in germination at equivalent water potentials of NaCI and PEG-8000 was mainly due to an osmotic effect rather than did salt toxicity. ©2010 Academic Journals.
Ghrabi-Gammar Z.,Banque Nationale de Genes |
Ghrabi-Gammar Z.,Manouba University |
Ben Haj Jilani I.,Manouba University |
Ben Haj Jilani I.,Institute National Agronomique Of Tunisie |
And 4 more authors.
Acta Horticulturae | Year: 2010
Ghomrassen is a rustic Berber village in south-eastern Tunisia, located 16 km from Tataouine and 40 km from Médenine. It is a municipality about 12000 inhabitants. Allagua is a very ancient Tunisian tradition especially famous in southern Tunisia. The term Allagua in the Ghomrassen region refers to a basket containing several objects (items), especially related to beauty and medicinal usages, that the new husband offers to his future wife during wedding festivities. This tradition dates to the time when the elementary care could be made only by the traditional medicine. The objective of our work is to collect information, so far untranscribed relating to the characteristics and use of plant-derived and other Allagua items, including the used plant organ, the origin, the type and mode of usage. An ethnobotanic survey was conducted in the Ghomrassen region during summer 2007, involving 20 resource persons (5 storekeepers, 5 chemists or plantssellers and 10 elderly women) known as having a deep knowledge of wedding ceremony traditions at Ghomrassen. Survey data were collected and analyzed, covering every inventoried species. More than 36 different articles were inventoried, including 10 of mineral origin and 20 of plant origin. The plant-originating items make up approximately 56% of all Allagua items. They belong to 20 different genuses in 18 families. The most important species are: Prunus mahaleb, Lawsonia inermis, Santalum album, Myrtus communis, Chamaeleon gummifer, Juglans regia, Atractylis gummifera. The majority of inventoried items are not exploited as raw materials. In fact, 15 items are used as ingredients of several special preparations including the Skhab preparation (made up of 9 items), the Henna and Bkhour (each made up also of 9 different items), the Mardouma (4 items) and the Kohl (2 items). Ten items articles belonging to 10 different plants are used for medicinal purposes and are generally present in the Allagua of the future bride. However, 80% of the surveyed persons indicated that the medicinal usage of these items is more and more abandoned, and they are less and less supplied in the Allagua. The tradition of necklace making is still transmitted from one generation to another and research studies on improving paste quality (colour, consistency, smell) are conducted by the National Office of Crafts. Today, several traditional and modern craft creations are marketed. On the other hand, Allagua components of medicinal usage are more and more abandoned in spite of the scientific validation of such usage.


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There's nothing more I treasure than family time, so once in a while we have the family over for a meal at our place. Christmas dinner this time round was a 5 (+2)-courser mix of east and west ;p
Readily available from our freezer - junk food to hold off hunger pangs
Extra mashed potato from shepherd's pie
Spicy tuna wontan
Kong ba bao in Korean sauce
The Sherpherd's Pie
Salted egg yolk French beans
Scallops with shitake and spinach in cream sauce
I must say my dad was pretty impressed with the spread he asked where I picked up my culinary skills from?! It's not from motherhood, dad, it's a natural talent not displayed when I was staying with you and the kitchen belonged to mummy ;p


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Yes. Another winner last night, when we predicted a big win for Iceland. The small nation ended up beating Liechtenstein with 4-0, and we got the lovely 1.8 in return. Today we take a look at an early match, when Japan is up agaist Bosnia in Kirin Cup.
In Japan four nations are taking place in the Kirin Cup. Bulgaria, Denmark, Bosnia and Japan. Japan beat Bulgaria with 7-2 in the first match, while Bosnia managed to claim a win against Denmark after being behind with 2-0. It was due to a very poor second half from Denmark and not because Bosnia played well.
Click here to bet -->
Japan is playing at home, and they looked fantastic against Bulgaria, and even though Bosnia is a tougher opponent, they are still without a lot of regulars.
Japan will win this match, the question is however how much they are going to win it with. I expect a min. win of two goals, so our bet is Japan -1.5.
Bet on Japan - 1.5 AH. Odds 2.30 at bet365.


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April 17, 2007
Today, more than half of our country is dependent on Washington, continuing a trend that should disturb anyone who doesn't consider himself or herself a socialist, says Investor's Business Daily.
According to Gary Shilling, an economist in Springfield, N.J.:
- Some 52.6 percent of Americans, which includes dependents of direct recipients, now receive significant income from government programs.
- Seven years ago, that number was 49.4 percent; in 1950, a mere 28.3 percent of Americans relied on Washington.
- Shilling says that if the current pace is not abated in 10 years, the percentage could exceed the 55 percent mark of 1980, the year Reagan was elected on a platform of scaling back the federal behemoth.
- By 2040, it could be 60 percent, Shilling reckons.
How did we get here? According to Shilling:
- About 20 percent of Americans rely on Washington for their income through federal jobs or jobs that are connected to the government.
- Another fifth have a government pension or receive Social Security; 19 million take food stamps; 2 million live in subsidized housing and 5 million accept education grants.
This bodes ill for any prospects of cutting government back to any reasonable size and reforming our messy and intrusive tax system, says IBD. While rates have been cut during President Bush's stay in the White House, it's a good bet that a decade from now a return to punitive taxation will be easier to legislate than tax cuts.
How long before the most productive Americans decide that they will no longer prop up the poorest and least productive? They'll have the option to either seek a tax-haven nation where government isn't a growth industry, or they can choose to be less productive, says IBD.
Source: Editorial, "Living off of Others," Investor's Business Daily, April 17, 2007.
Browse more articles on Tax and Spending Issues


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ex·empt (ĭg-zĕmpt)
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tr.v. ex·empt·ed, ex·empt·ing, ex·empts
1. To free from an obligation, duty, or liability to which others are subject: exempting the disabled from military service.
2. Obsolete To set apart; isolate.
1. Freed from an obligation, duty, or liability to which others are subject; excused: persons exempt from jury duty; income exempt from taxation; a beauty somehow exempt from the aging process.
2. Not subject to certain federal workplace laws or protections, especially those requiring overtime compensation: exempt employees.
3. Obsolete Set apart; isolated.
One who is exempted from an obligation, duty, or liability.
[Middle English exempten, from Old French exempter, from exempt, exempt, from Latin exemptus, past participle of eximere, to take out; see EXAMPLE.]
ex·empti·ble adj.
The American Heritage® Dictionary of the English Language, Fifth Edition copyright ©2017 by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
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Hats; (FIRST USE: 09/03/2011; USE IN COMMERCE: 09/03/2011) Tee shirts; Wearable garments and clothing, namely, shirts
Business in Wethersfield, CT


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We have a bunch of friends who are always telling us to go and check out Bonefish Grill for dinner, but we hadn't had the chance to dine there until the folks at Bonefish Grill invited us to stop in and check out their new seasonal Fall Menu they were rolling out. With our friends recommendation to try out Bonefish Grill in our head, we accepted the invitation and made a reservation for a dinner date at their Omaha location. This post contains sponsored content brought to you by Bonefish Grill. We were invited guests for this event and received consideration for our time, but all opinions presented here are 100% our own. For further information please see our Disclaimer page.
Full of flavors from the fall, Bonefish Grill's Dine and Discover seasonal menu features a three course meal for two that pairs up their signature appetizer Bang Bang Shrimp with a choice of entree and a delicious tempting dessert all for $50. The entrees featured on this menu were designed to showcase some great seasonal seafood to celebrate National Seafood Month and highlight some of the great flavors of fall. Choices like swordfish with pumpkin ravioli, cedar plank maple bourbon salmon, and a wild snapper and shrimp plate all carefully crafted to bring great tasting seafood and fall flavors to your plate.
We stopped in for our dinner date on a recent Thursday night to find the place hopping. The bar area where we were waiting was lively and full of customers, but once we were taken back to the dining area, the atmosphere gets more intimate and quiet. We started out by ordering the two special fall cocktails, the Fall Apple Martini and the Fresh Pear Martini.
The Fall Apple Martini was our favorite, with apple infused vodka finished with honey and cinnamon, the aromatic cinnamon perfuming the drink and finishing with a crisp apple tartness. A nice combination of sweet and spice, the garnish of a fresh apple slice made for a great nibble while sipping on this martini.
The Fresh Pear Martini features muddled fresh fall pears, Absolut Pear and St Germain Elderflower Liqueur. A squeeze of tart lemon adds bright burst of citrus that cuts the sweetness of the pear and St. Germain. Boldly full of pear flavor, the Fresh Pear Martini is a nice combination of fruit and floral.
Both of us are big fans of fresh baked bread, and Bonefish Grill serves fresh baked bread with each meal. A fresh baked loaf arrived at the same time as our cocktails, warm and perfectly baked, the crust crispy while the center was airy and soft. A small shallow plate of fresh oil and herbs accompanied each loaf that made for a delicious dipping.
We were looking forward to the famous Bang Bang Shrimp for our appetizer as we have two friends that absolutely gush about the Bang Bang Shrimp! The Bang Bang Shrimp is probably the most popular dish at Bonefish Grill, crispy fresh shrimp coated in a creamy and spicy garlic sauce atop a bed of crisp lettuce. This was a pretty satisfying appetizer, the nice bold spicy bite a great way to get your appetite going.
Mrs. Nom ordered the Cedar Plank Maple Bourbon Salmon and I ordered the Swordfish with Pumpkin Ravioli. The Swordfish and Pumpkin Ravioli were our favorites, a great combination of meaty fish and delicious fall pasta. The pumpkin ravioli were fantastic, lightly buttered and served with crispy green onions and feta cheese crumbles, the pumpkin sweet and earthy and a great partner to the swordfish.
Mrs. Nom's Cedar Plank Bourbon Salmon came with a nice fillet of wild caught Norwegian salmon that had been marinated in a maple and bourbon marinade and then grilled on a bourbon soaked cedar plank while being glazed in the maple and bourbon marinade to create a caramelized glaze. A side of rainbow carrots and jasmine rice accompanies the salmon. Mrs. Nom isn't big on jasmine rice, so she opted to sub in the garlic mashed potatoes, which she really enjoyed.
For dessert, we chose to go with a classic dessert and get the creme brulee to finish our meal. Bonefish Grill has a special pumpkin creme brulee on the Dine and Discover menu which is a decedent combination of pumpkin, nutmeg and cinnamon finished with house made whipped cream. Since we had recently nearly overdosed on pumpkin during some recipe development for the blog, we chose to skip the pumpkin creme brulee and finish our meal with the classic creme brulee. Deliciously creamy and with a perfectly crunchy caramelized sugar top, the creme brulee was fantastically done and when combined with the delicious house made whipped cream was the perfect finish to our meal!
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Sabihin Ko Na Kaya
Filipinos music song title: Sabihin Ko Na Kaya. Singer: Marco Sison . Most Filipinos home now a day have karaoke machine, if you have a CDG machine, you might be able to locate this song # 07362 Enjoy this song music video clips below.No longer available
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You can pretty much bet there was a lot of cheering when Judge Robert D. Drain erased a $461,263 mortgage claim in a New York bankruptcy case. This sounds like a big victory for the good guys — but before the celebrations get out of hand it might be wise to sort out the winners and losers.
In basic terms, the PHH Mortgage went into a bankruptcy court to collect an unpaid mortgage debt. This is a natural and normal process and the usual outcome is fairly common: Given the inability of bankruptcy judges to modify residential mortgages the unpaid debt is usually seen as earned, due and payable and the property is instantly foreclosed.
But this time around the debtor made a different argument, one we are likely to see more often. While it may be that bankruptcy judges cannot modify mortgage loans under the so-called Bankruptcy Abuse Prevention and Consumer Protection Act of 2005, lenders still have to show that they actually have a claim.
Speaking for the homeowner, attorney David B. Shaev argued that the PHH is the loan "servicer" while the U.S. Bank National is the "trustee" for a securitized trust that actually owns the debt. A securitized trust, in turn, could be a mortgage-backed security (MBS) with many investors.
As a servicer, said Shaev, PHH had no claim against the homeowner. He argued that:
- PHH is not the beneficiary of the note;
- PHH has no financial rights under the note;
- PHH is not the real party in interest;
- The real owner of the mortgage, U.S. Bank, is not a party to the court case;
Due to all of the above, PHH has no standing to file the proof of claim in this bankruptcy.
PHH, according to Shaev, could not even prove that it was the servicer because it could not produce the Pooling and Servicing Agreement ("PSA") which would give it authority to collect the debt. Also not proven, according to Shaev, is who actually owned or was holding the mortgage note.
Judge Drain ultimately ruled against PHH and accepted Shaev's arguments.
The PHH decision, says The New York Times writer Gretchen Morgenson, "may put a new dynamic in play in the foreclosure mess: If the lender can't come forward with proof of ownership, and judges don't look kindly on that, then borrowers may have a stronger hand to play in court and, apparently, may even be able to stay in their homes mortgage-free." (See: If Lenders Say 'The Dog Ate Your Mortgage', October 24, 2009.)
Sounds great, but Morgenson — a financial writer who I generally admire — has seriously missed the point on this one.
The Legitimacy of Debt
In the PHH case there was never a dispute that a mortgage was originated. The borrower got a mortgage, but for purposes of collecting the debt the issue was who actually owned the note or represented the note holder at the time of the bankruptcy. If you're not the loan owner or owner's agent then you have no right to foreclose on someone's home.
While Morgenson says judges have not looked kindly at loan claims by lenders who cannot produce notes, the opposite is true. Most foreclosure actions whiz through the legal system because in many cases no court action is required and — when a hearing is required — judges have routinely accepted claims regarding the electronic assignment of notes. There's a reason why law firms which handle lots of real estate cases are called "foreclosure mills."
Only recently — most notably with the 2007 decision of Judge Christopher Boyko to stop 14 foreclosures in Ohio — have judges begun to demand proof of loan ownership from lenders.
The result is a small but growing number of court cases where lenders, servicers and trustees have been required to show that they have physical possession of the note and that servicers and trustees have the right to represent note holders in court.
Despite such minimal barriers to foreclosure, in many instances appropriate paperwork cannot be found. The lack of paperwork is not a problem for lenders when judges don't ask for such evidence or where a borrower does not have an attorney, but more and more often judges do ask and more and more borrowers now have lawyers. From this point forward foreclosures may not be so fast or so easy.
The Marketplace Threat
"The problems note holders face in proving their foreclosure claims should not obscure the fact that mortgages were made, security was pledged and payments are due," says Jim Saccacio, Chairman and CEO at RealtyTrac.com, the leading online marketplace for foreclosure properties. "A wholesale dumping of lender claims would be disastrous, not just for lenders but for all property owners."
Imagine that a few lenders lose track of their notes and that borrowers start hiring lawyers when faced with foreclosure. Imagine too that a small number of well-publicized mortgage claims are erased.
What would happen next? For some borrowers the new system would be like winning the lottery, but for the rest of us the dollars available for mortgages would disappear. Why would investors want to buy new mortgage-backed securities if the mortgages are uncollectible? It would make equal sense to invest in czarist railroad bonds or ENRON futures.
With fewer dollars from investors, what happens the next time you want to finance or refinance a home? Either the money won't be there or it will only be there at insanely-high rates.
Ask yourself: What would happen to the value of your home if it can't be financed when you want to sell? How many people can pay cash? And how much cash do you think they would offer if mortgages were largely unavailable?
The PHH case is wrongly decided for a very simple reason: If it's true that PHH had no right to sue, why should U.S. Bank be punished? That's the direct result of erasing the mortgage claim in this case. It's not PHH that's being hurt or the borrower, it's U.S. Bank — the folks who put up the cash to originate or buy the loan.
What To Do
Some time ago I was speaking with the friendly folks at the IRS about their record-keeping system. How far back, I asked, does your system go? Remarkably, they were instantly prepared to send complete copies of my returns — going back to the 1960s.
There's a lesson here for the lending industry. It's time mortgage records were right and instantly accessible.
Why not a central depository where all mortgage notes are physically maintained — with back-up centers in other geographic areas? The notes would be bar coded, digitally copied, and available online. In other words, if FedEx and UPS can track packages minute by minute, why can't lenders do the same with notes and deeds?
A city, for example, would be able to instantly access all notes for a given property. Title companies would be able to get certified copies instantly. Closing agents would be given serial numbers to use the system and upload new notes. Local property records offices would be paid for an official recordation each time a note is originated, transferred, assigned or paid off. Notes could be physically moved by certified mail with return receipts or by overnight delivery — but in all cases paper notes would be tracked from the moment of origination until pay-off.
I really do mean minute-by-minute tracking. There are printing facilities which track paper from machine to machine and from place to place using barcodes. If you can't find a piece of paper you always know where and when it was last spotted.
The IRS has its major records center in West Virginia. There's plenty of land available there and elsewhere for additional records centers, but there's no room for the instability which now plagues the mortgage system and threatens home values nationwide.
Peter G. Miller is syndicated in more than 100 newspapers and operates the consumer real estate site, OurBroker.com.


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Immaculate Wedding Photographer in Sarnia, Ontario
Is it accurate to say that you are searching for an expert picture taker who has the masterful vision, specialized abilities, and identity to catch your wedding? On your big day, the decision of picture taker is a standout amongst the most essential choices that you will make.
Cindy June is an expert picture taker in Sarnia wedding photographers who comprehends the complexities of a wedding occasion. She's an expert who knows how to mix in, comforting your visitors and taking easygoing photographs that you will love. She trusts that a decent picture taker needs specialized aptitudes, additionally the capacity to identify with individuals, permitting them to open up and demonstrate their one of a kind delight. Cindy June trusts: "A photo can endure forever and past – everyone speaks to a minute in time that you can't get back, however can re-live." Cindy June realizes that every photograph she takes of the wedding speaks to a unique minute that you can remember. That is the reason she invests energy becoming more acquainted with you, to comprehend what is one of a kind about your occasion and what minutes you need to recall for whatever is left of your life.
Cindy June is not just a specialist at getting the ideal easygoing shots; she likewise comprehends the arranging and sorting out that is important to get astounding formal shots. She leads the pack and works effectively, keeping your visitors connected with and at the time. With her in charge, you will have your photos done much sooner than your visitors have lost tolerance.
A portion of the minutes Cindy June catches include:
- Lady of the hour and Groom Portraits
- Wedding Party Photos
- Easygoing Photographs of Reception/Wedding
- The Ceremony
- Family Photos
- Sustenance and Décor Photos
Cindy June adores helping Sarnia wedding photographers couples protect their unique day. She is as put resources into saving your wedding minutes as you are – that is the thing that makes her such an esteemed picture taker in Sarnia, Ontario. With Cindy June in charge, you won't need to stress over the photos; you will realize that they are in great hands. The sentiment, energy and the last acknowledgment of months, possibly years, of making arrangements for this one day and it's the wedding picture taker's business to catch these feelings in a reasonable yet, delightful way. The lady of the hour and lucky man will be apprehensive, the guardians trusting everything keeps running as easily as they have made arrangements for and the children, making an effort not to look excessively exhausted with the entire whine around them. I frequently catch some awesome photos of the children at weddings. The photos ought to mirror the occasions of the day in a manner that, thinking back, when you're an old wedded couple, it will appear like the wedding was just yesterday.
Every one of the points of interest should be captured, including the congregation or venue for the function and obviously, the gathering. As a wedding picture taker, I think of it as a crucial piece of my work, to arrive before the actual arranged time, become more acquainted with the design of wedding venue, select the best positions and plots for the shots that I need to catch, amid the function and endeavor to deliver inconceivable photographs.
Sadly, there are still a few people who won't permit the religious service to be captured which is another reason I get a kick out of the chance to arrive before the actual arranged time, to give myself the chance to talk with the priest, minister or authority who will direct the function and if conceivable, pick up a little trade off, in such cases. A decent wedding picture taker will know about every one of the ranges to consider for each event. You're wedding will be special and you're wedding photos ought to likewise be one of a kind.
Get in touch with me for any request you may have. We should begin catching your recollections with my expert photography administrations.


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C&S Papers Series (CD-ROM) No. 11
Subject Classification: 0200-Food and Agriculture
€ 15.00;
Date Published: 2002
This CD-ROM publication reports on the FAO/IAEA Symposium on Nuclear Techniques in Integrated Plant Nutrient, Water and Soil Management. The seven themes selected for this international symposium were: 1. Evaluation and management of natural and manufactured nutrient sources; 2. Soil organic matter dynamics and nutrient cycling; 3. Soil and water management and conservation; 4. Plant tolerance to environmental stress; 5. Environmental and pollution studies; 6. Assessment of soil erosion and sedimentation; 7. Recent advancements in isotope analytical methodologies and related instrumentation.
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INTERNATIONAL ATOMIC ENERGY AGENCY, Nuclear Techniques in Integrated Plant Nutrient, Water and Soil Management, C&S Papers Series (CD-ROM) No. 11, IAEA, Vienna (2002).
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Tadcaster swimming pool is holding a Big Splash open day tomorrow, Saturday, where visitors will get a chance to dive in for a £1.
Visitors will get the chance to view the pool and gym facilities, chat to staff over a cup of tea and get a taste of the activities on offer to achieve a healthy lifestyle. There will also be discounted swim sessions, 1-2-1 swimming lessons and the chance to try out an underwater mp3 player.
Swimming sessions will begin at noon, with a 'Swim for a £1' event. This will be followed by a 'Fun Splash' family swim session for a £1 per person.
At 3pm individuals interested in learning to swim can enjoy a 1-2-1 taster lesson with a qualified instructor for £5.
The pool is also offering individuals the opportunity to win a £50 voucher, by filling out a quick online survey about the facilities.
For more details go to www.tadcasterpool.org.uk or call 01937 833001.
l Volunteers who are helping to run Tadcaster Community Swimming pool gave their local MP a tour of the venue this week.
The pool is managed by full-time staff with the help of a large number of volunteers and receives no funding from North Yorkshire County Council.
They were visited by MP Nigel Adams this week in a bid to raise awareness about how the pool operates.
Chris Porter, facilities manager at the pool, said: "Mr Adams visit was a chance to him all the work we do here and others that the big society is actually working, we have been running this pool for nearly 17 years largely through the help of the community, as we rely heavily on donations and the hard work of local people."
If you would like to volunteer at the pool go to www.tadcasterpool.org.uk.


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Category Archives: Language
French Language Week
Apologies to subscribers via MailChimp, which has played tricks and not included the link to the post in the alert. Hopefully, you have got here by clicking on the blog title at the top of the alert. Today is the … Continue reading
Posted in Language Tagged Brexit, etiquette, French, French citizenship, French citizenship language test, French language, French test, Language, SW France 12 Comments
What Difference Will French Spelling Changes Make?
First, I have to note that it's six years today since I pressed the 'go live' button on this blog. Since then, I've published 496 posts, made a lot of virtual friends and had a ball researching into French life, … Continue reading
Language Larks: What French Words Mean Depends on Where You Live
Just a short post this week, for reasons that will become apparent later. Before we moved here, in my ignorance I had always assumed that French was a pretty homogeneous language and that the vocabulary of Lille must also be … Continue reading
Posted in Language Tagged French, French language, French vocabulary, Language, Occitan, phrases, SW France 41 Comments
A Question of Accent
I speak French with an English accent. Try as I might, I can't get rid of it, even though my French is now pretty fluent after 18 years here. As soon as I open my mouth, I give myself … Continue reading
Posted in French life, Language Tagged English accent, Expat, French, French accent, French pronunciation, Language 37 Comments
More Difficult French Phrases
Difficult for we non-French, that is. While writing an email to a French friend recently I had to consult the dictionary several times to make sure I got a particular construction right. This is after more than 16 years in … Continue reading
Posted in Language Tagged French, French grammar, French language, Language, language learning, Language mistakes 23 Comments
An Opportunity to Meet French Schoolchildren
We attended a rather nice event last Friday at a school in Villefranche-de-Rouergue. Le Lycée Beauregard, a secondary school, invited local English speakers to meet the students and talk to them – in English.
Posted in French life, Language Tagged English, Expat, French, Language, language learning, Lycée Beauregard, Villefranche de Rouergue 4 Comments
The Same Country Divided by Countless Languages
Today we paid an Easter visit to our elderly neighbours, M. et Mme. F. We are very fond of them but our conversations with them are sometimes characterised by total incomprehension on our side. This is not just a cultural … Continue reading
Posted in History, Language Tagged Graham Robb, Language, language development, linguistic diversity, Occitan, Occitan hymn, Se canto, SW France, The Discovery of France 24 Comments
French Acronyms
Since the world is going to end on December 21st this year, I had better get blogging. You hadn't heard? But I told you back in January. The only place that will escape the cataclysm is Bugarach in the Pyrénées … Continue reading
Posted in French life, Language Tagged acronyms, France, French, Language, living in France, phrases, sigles 10 Comments
Yet More French Colloquial Phrases
French is a remarkably colourful language. When at school, struggling to conjugate irregular verbs and make nouns and adjectives agree, I would certainly have disagreed with that statement. Having struck up a more intimate acquaintance with the language during our … Continue reading
Posted in Language Tagged Académie française, colloquial phrases, French, Language, Luc Ferry 6 Comments
French Test or Testing French
Just a short post today. I have been rather snowed under with article commissions recently. I'm not complaining – after all, it's partly how I earn my corn. But it doesn't leave much time for other things. If you were … Continue reading
Posted in Language Tagged French, French grammar, Language, Les Timbrés de l'Orthographe 12 Comments
Found(ering) in Translation
We've just got home from a choral concert given in the Eglise de Saint-Andéol (above) at Parisot. The Chantier Voix choir from Limogne (Lot) interpreted a range of songs from negro spirituals to Russian Orthodox sacred music to Corsican polyphonic chants. Very good it … Continue reading
Posted in French life, Language Tagged Faux amis, French, Language, Language mistakes, learning language, literal translation 14 Comments
More French Colloquial Phrases
There are hundreds, possibly thousands, of French colloquial phrases. I wrote about a few of the more common ones a while back. I read in the Figaro Magazine last weekend that a new book had been published about those that … Continue reading
Posted in Customs, Language Tagged colloquial phrases, France, French, Language, phrases, phrases using animals 10 Comments
Naming La Lune
Since I've changed my blog's name, I've also done a bit of research about La Lune, our lieu-dit. In addition to my Kindle, I received a proper printed book for my recent birthday. Knowing my addiction to history – I … Continue reading
Posted in French life, History, Language, Places Tagged France, history, La Lune, local history, Occitan, place names, SW France, toponymy Leave a comment
Speaking in tongues; or why I have trouble with my own language
For a writer this is a rather serious problem. I realise that my command of English leaves something to be desired these days. Fourteen years in France have eroded my ability to wield the language of Shakespeare in the way … Continue reading
Posted in French life, Language Tagged English, France, French, Language, language evolution, living in France, Shakespeare, SW France 8 Comments
French Regional Accents: comment?
We have just returned from a 10-day holiday in Corsica, hence the lack of posts, comments etc for a while. I did schedule this post to appear while I was away, but for some reason it didn't, so here it … Continue reading
Posted in Customs, French life, History, Language, Personalities Tagged France, French, Language, living in France, Occitan, Pronunciation, rural life, SW France 6 Comments
Exams French style
I mentioned a while ago (see the post here) that I had been selected for the regional finals of a French national competition called Les Timbrés de l'Orthographe, to find the people in France who master French grammar the best. … Continue reading
Posted in French life, Language, Places Tagged épreuves, exams, France, Language, Les Timbrés de l'Orthographe, living in France, SW France, Toulouse 10 Comments
My French isn't that bad, then
French, as I have often remarked on these pages, is fiendishly difficult. It's a far more precise language than English, so if you use a word that's slightly wrong or a grammatical construction that is less than perfect, you risk … Continue reading
Posted in French life, Language Tagged France, French, grammar, Language, Les Timbrés de l'Orthographe, living in France, Philippe Delerm 8 Comments
French colloquial phrases you never learnt at school
See also my post More Colloquial French Phrases. For my other posts about the French language, please click on 'Language' under Topics in the right-hand sidebar. French, like all languages, has its colloquial phrases. The pure French that we learnt … Continue reading
Posted in Books/writing, French life, Language Tagged colloquial phrases, France, French, idiomatic expressions, Language, language learning, living in France, phrases, Writing 2 Comments
The top ten Maigret novels
'What on earth has Georges Simenon's Maigret got to do with living in southwest France?' you might ask. And you'd be absolutely right. Very little, is the answer, at least on the face of it. However, I've often said … Continue reading
Posted in Books/writing, French life, Language, Personalities, Top tips Tagged France, French, French novels, Maigret, Simenon, Writing 7 Comments
French novels – 10 of the best, nos. 6-10
A selection of the top 10 French novels, by A writer's lot in France. Continue reading
Posted in Books/writing, French life, Language, Top tips Tagged Balzac, blogs about France, books, French, French novels, Gautier, Literature, Mérimée, Mme de La Fayette, novels, Simenon, Writing 1 Comment
Surviving in France: 10 top tips
Living in France is very different from spending a couple of weeks on holiday here. Here are some commonsense tips to help you get the most out of living in France. Continue reading
Posted in French life, Language, Top tips Tagged blogs about France, Expat, France, French, French property, language learning, living in France, rural life, top tips 22 Comments
Language mistakes: 5 things to avoid saying in French
Translating literally from English to French is always dangerous. Many French words change their meaning depending on how they are used or which verbs they are used with. Also, hundreds of English and French words look similar but mean different … Continue reading
Posted in French life, Language, Top tips Tagged blogs about France, breaking news, English, etiquette, faux pas, France, French, phrases, words 5 Comments


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First overnight visit home from hospital - how did it go?
Hi everyone,
My son (18 yrs old TBI from being hit by a car 12 weeks ago) is coming out of the rehab hospital for an overnight stay - not at home but with me at his nans house. He has terrible trouble with his short term memory and I have to remind him of everything every day. Both his nan and I are worried about how he will cope overnight. Does anyone have any experience of this or any advice? Thank you.
Last edited by Ladyberd70


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Ki - Home form crucial
Ki Sung-yueng feels Celtic will have to win their home games to have a chance of progressing in the Europa League.
Last Updated: 26/09/11 10:46am
Ki Sung-yueng feels Celtic will have to win their home games in order to have a chance of reaching the knockout stages of the Europa League.
Celtic were handed a European reprieve after Sion were expelled from the competition, but started the group phase with a 2-0 defeat away to Atletico Madrid.
The Bhoys face Udinese in their first home match on Thursday and, in addition to welcoming 2010 winners Atletico to Parkhead, will also tackle French outfit Rennes.
Group I is arguably the toughest section in the first round and Ki is aware of the need for Celtic to claim maximum points in front of their own fans.
"We have just played one game and if we win against Udinese we still have a chance," said the South Korea international.
"We will have to be at our best and if we get a chance we will have to score.
"Away games in the Europa League or Champions League are not easy so we should at least draw away games and win every home game, that is our target.
"But as I said, it's not going to be an easy game because they are a good team.
"They are doing very well in Italy but it is our home game which means we have a lot of fans behind us. So we want to win the game."
Celtic warmed up for the visit of Udinese by beating Inverness 2-0 in the SPL on Saturday following goals from midfielders Joe Ledley and James Forrest, and Ki admits everyone in the Hoops engine room needs to chip in with goals.
"We can't rely on the strikers every time," said Ki, who has notched three so far this season.
"We have good midfielders in the team who can score goals and I think we should score more.
"Me, Beram Kayal, Joe and Scott Brown can score more goals and help the strikers to score."


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Rand Fishkin of SEOmoz announced that after a year of testing, developing, and analyzing on building out an index of the World Wide Web, in order to help SEOs and SEMs acquire greater intelligence about the Internet's vast landscape with a toolset they have never had before.
"SEOmoz has crawled and built a 30 billion page index of the web, this index is still growing and is refreshed monthly."
Part of the indexing was to build out a new tool called "Linkscape". Linkscape gives SEOs "online access to the link data provided by our web index, including ordered, searchable lists of links for sites & pages, and metrics to help judge their value," said Rand. I hope to play with it more after the SMX East conference, but with a quick trial, it seems pretty comprehensive.
Source:→ SEL


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Morgan handed Test spot
Eoin Morgan has been selected ahead of Ravi Bopara in England's squad for the first Test against Sri Lanka in Cardiff.
By Paul Higham Twitter: @SkySportsPaulH
Last Updated: 22/05/11 3:51pm
Eoin Morgan has been given the nod ahead of Ravi Bopara in England's squad for the first npower Test against Sri Lanka in Cardiff on Thursday.
All of the talk ahead of the squad announcement concerned who would be chosen to replace Paul Collingwood in the Test side, and it was the Middlesex left-hander who has been given the first chance to prove himself.
Morgan pressed his claims by making 193 for England Lions in their ongoing tour match against Sri Lanka in Derby, and he now looks like slotting in at number six for Andrew Strauss' men.
Pace bowler Steve Finn has been selected ahead of Ajmal Shahzad as the fourth pace bowling option along with James Anderson, Stuart Broad and Chris Tremlett.
Kevin Pietersen is also in the squad after recovering from the hernia problem that forced him out of the World Cup on the subcontinent.
"We believe we have selected a very strong squad for the first Test," said national selector Geoff Miller.
"Eoin Morgan impressed us last summer when he was given his opportunity in the Test side and has worked hard on his game throughout the tour of Australia and now has the opportunity to play a role in the Test team.
"Chris Tremlett had a very encouraging winter after a period of time away from the national side and - alongside Stuart Broad, James Anderson and Steven Finn - offers us a number of options with our pace attack."
The three-match Test series starts in Cardiff on Thursday and it will be England's return to five-day cricket for the first time since their historic Ashes series victory in Australia.
"We are very excited to be back playing cricket on home soil and are focused on building on the momentum we gained during the Ashes last winter," Milleradded. "Which was testament to the hard work that everyone involved put into the series.
"We currently have a talented and ambitious group of players who are committed to becoming the number one ranked side in Test cricket and we are determined to start an important summer strongly, beginning against Sri Lanka in Cardiff."
England squad: AJ Strauss (Middlesex, captain), JM Anderson (Lancashire), IR Bell (Warwickshire), SCJ Broad (Nottinghamshire), AN Cook (Essex), ST Finn (Middlesex), EJG Morgan (Middlesex), KP Pietersen (Surrey), MJ Prior (Sussex), GP Swann (Nottinghamshire), CT Tremlett (Surrey), IJL Trott (Warwickshire)


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Mosquito Control Kit
Buy Now
Laura from Las Cruces, Nm writes,
Which product would be best around pets? Dogs, a chicken and a koi pond? Thanks
We are concerned about west nile. I get bitten a half a dozen times everytime I go outside, even with repellent on. I do use dunks in the pond and fountain and change the dog water.
Most products including the Mosquito Control Kit (Bifen and BTI Dunks) are safe around children and pets. However, the pond is much different. Since there is a Koi pond on your property we would recommend that you use the EcoVia EC which is a safe, natural, organic insecticide that is safe for all aquatic life as well as pets and other animals.
Answer last updated on: 07/16/2014
2 of 2 people found this answer helpful. Was it helpful to you? Yes No


text:
Appointments, promotions and awards in the business community.
Seattle area
Aerospace: Kris Kutchera was named managing director of applications development and Shannon Alberts managing director of investor relations at Alaska Airlines.
Architecture: Jonathan Chang was named an associate principal at Callison Architecture. Mark Cork was named a principal at Mahlum Architects.
Banking: Chris Heman was promoted to senior vice president and region manager at U.S. Bank. Gerry Hatler was named president and chief executive at EvergreenBank's new office in downtown Seattle. Peggy Agress was hired as an assistant controller at HomeStreet Bank.
Engineering: Robin Nelson was elected president of the board of directors at Hammond Collier Wade Livingstone.
Health care: Lori Anderson was named divisional director of women's services at Highline Medical Center, Burien.
Law: Marisa Bavand and Michael Grace became partners at Groff Murphy Trachtenberg & Everard. Ruby Hou Alexander joined Perkins Coie as an associate. Miyuki Yoshida joined Lane Powell as an associate. Aaron Brown joined Cozen O'Connor as an associate. Nathan Hoerschelmann joined Gordon Thomas Honeywell Malanca Peterson & Daheim as an associate. Lance Losey was appointed chairman of the estate-planning and probate group at Ryan, Swanson & Cleveland. William "Skip" Fisher joined Schwabe, Williamson & Wyatt as a shareholder.
Technology: Alix Erickson was promoted to vice president, programs, at WSA (formerly the Washington Software Alliance).
Banking: Mike Ralph was hired as a vice president and loan officer at HomeStreet Bank, Bellevue. Chris Vanbellinghen was hired as a vice president and banking center manager at First Mutual Bank, Issaquah. Jeffrey Porter was promoted to assistant vice president and banking- center manager at First Mutual Bank, Juanita. Ann Snow was promoted to assistant vice president and banking-center manager at First Mutual Bank, Sammamish.
Convention centers: Krystal Turney was hired as human- resources manager at Meydenbauer Center, Bellevue.
Wireless communications: Mike Kent was appointed vice president at Action Engine.
To be included in the On the Move column, send the information to Gary Dougherty by fax, 206-382-8879; e-mail, firstname.lastname@example.com; or mail, The Seattle Times, P.O. Box 70, Seattle, WA 98111. Photos will not be returned.


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hi. i have windows 7 on my machine and i installed debian in dual boot using manual partitioning method during the install. it looked like this before i started the actual process of installing:
#1 primary 104.9 mb B ntfs
#2 primary 794.7 gb ntfs
#3 primary 104.9 gb ntfs
#5 logical 92.2 gb F ext4 /
#6 logical 8.4 gb F swap swap
so it says that swap will be 8.4 gb but now after i reboot the system after the install swap is 7.45 giga. how can it be????????


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Can you Guess Which is The Best City in Texas for Spirits and Beer?
Lana Del Rey and Others Use Witchcraft to Ward Off Negative President Trump Energy
Anheuser-Busch And Keurig Are Teaming Up For An In-Home Booze DispenserNever thought you'd see those two names together in a headline, did you?
Ghost Photobombs Ghost Hunters - See The Pic!
Wild Turkey: The Journey Begins with Matthew McConaugheyMatthew McConaughey is the new creative director for Wild Turkey and his first commercial is very promising.
Was This Couple's Wedding Photo Bombed By A Ghost?Does the image in the photo look like a ghost to you?
Keep Your Sunday Night Open For The Black KeysHey...we were fans of these guys WAY before they were playing big arenas. At least that's what we tell people.
Land The Winning Bid At The Collector Car AuctionThe highlight for us: a 1977 AMC Pacer. Don't laugh...that automobile is a sex machine.
The 2nd Annual Dallas Whiskey & Fine Spirits Festival Is Coming SoonSip. Don't gulp.
Iron Fork Returns
Savor Dallas
Have A Beer With Pearl Jam


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All Topics
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Infectious Diseases
Mental Health
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Track topics on Twitter Track topics that are important to you
Gadolinium-based contrast agents (GBCAs) increase the risk for NSF among patients with impaired elimination of the drugs. Avoid use of GBCAs in these patients unless the diagnostic information is essential and not available with non-contrasted MRI or other modalities. NSF may result in fatal or debilitating systemic fibrosis affecting the skin, muscle and internal organs.
MultiHance is indicated for intravenous use in magnetic resonance imaging (MRI) of the central nervous system (CNS) in adults and children over 2 years of age to visualize lesions with abnormal blood brain barrier or abnormal vascularity of the brain, spine, and associated tissues.
The recommended dose of MultiHance is 0.1 mmol/kg (0.2 mL/kg) administered as a rapid bolus intravenous injection. To ensure complete injection of the contrast medium, follow the injection with a saline flush of at least 5 mL.
Inspect the MultiHance vial visually for particulate matter and discoloration prior to administration. Do not use the solution if it is discolored or particulate matter is present. Draw MultiHance into a syringe and inject using sterile technique.
Do not mix intravenous medications or parenteral nutrition solutions with MultiHance. Do not administer other medications in the same intravenous line with MultiHance.
MultiHance vials are intended for single use only. Administer immediately after opening and discard any unused product.
MultiHance is a sterile, nonpyrogenic, clear, colorless, aqueous solution for intravenous use only, containing 529 mg gadobenate dimeglumine per mL.
MultiHance is contraindicated in patients with known allergic or hypersensitivity reactions to gadolinium-based contrast agents [ see Warnings and Precautions (5.2) ].
Gadolinium-based contrast agents (GBCAs) increase the risk for nephrogenic systemic fibrosis (NSF) among patients with impaired elimination of the drugs. Avoid use of GBCAs among these patients unless the diagnostic information is essential and not available with non-contrast enhanced MRI or other modalities. The GBCA-associated NSF risk appears highest for patients with chronic, severe kidney disease (GFR <30 mL/min/1.73m) as well as patients with acute kidney injury. The risk appears lower for patients with chronic, moderate kidney disease (GFR <30-59 mL/min/1.73m) and little, if any, for patients with chronic, mild kidney disease (GFR 60-89 mL/min/1.73m). NSF may result in fatal or debilitating fibrosis affecting the skin, muscle and internal organs. Report any diagnosis of NSF following MultiHance administration to Bracco Diagnostics (1-800-257-5181) or FDA (1-800-FDA-1088 or www.fda.gov/medwatch).
Screen patients for acute kidney injury and other conditions that may reduce renal function. Features of acute kidney injury consist of rapid (over hours to days) and usually reversible decrease in kidney function, commonly in the setting of surgery, severe infection, injury or druginduced kidney toxicity. Serum creatinine levels and estimated GFR may not reliably assess renal function in the setting of acute kidney injury. For patients at risk for chronically reduced renal function (e.g., age > 60 years, diabetes mellitus or chronic hypertension), estimate the GFR through laboratory testing.
Among the factors that may increase the risk for NSF are repeated or higher than recommended doses of a GBCA and the degree of renal impairment at the time of exposure. Record the specific GBCA and the dose administered to a patient. For patients at highest risk for NSF, do not exceed the recommended MultiHance dose and allow a sufficient period of time for elimination of the drug prior to re-administration. For patients receiving hemodialysis, physicians may consider the prompt initiation of hemodialysis following the administration of a GBCA in order to enhance the contrast agent's elimination. The usefulness of hemodialysis in the prevention of NSF is unknown [ see Dosage and Administration (2) and Clinical Pharmacology (12) ].
Anaphylactic and anaphylactoid reactions have been reported, involving cardiovascular, respiratory, and/or cutaneous manifestations. Some patients experienced circulatory collapse and died. In most cases, initial symptoms occurred within minutes of MultiHance administration and resolved with prompt emergency treatment.
Prior to MultiHance administration, ensure the availability of personnel trained and medications to treat hypersensitivity reactions. Additionally, consider the risk for hypersensitivity reactions, especially in patients with a history of hypersensitivity reactions or a history of asthma or other allergic disorders. Observe patients for signs and symptoms of a hypersensitivity reaction during and for up to 2 hours after MultiHance administration.
In patients with renal insufficiency, acute renal failure requiring dialysis or worsening renal function have occurred with the use of gadolinium-based contrast agents. The risk of renal failure may increase with increasing dose of the contrast agent. Screen all patients for renal dysfunction by obtaining a history and/or laboratory tests. Consider follow-up renal function assessments for patients with a history of renal dysfunction.
Extravasation of MultiHance may lead to injection site reactions, characterized by local pain or burning sensation, swelling, blistering, and necrosis. In animal experiments, local reactions including eschar and necrosis were noted even on Day 8 post perivenous injection of MultiHance. Exercise caution to avoid local extravasation during intravenous administration of MultiHance. If extravasation occurs, evaluate and treat as necessary if local reactions develop.
Cardiac arrhythmias have been observed in patients receiving MultiHance in clinical trials [ see Adverse Reactions (6.1) ]. Assess patients for underlying conditions or medications that predispose to arrhythmias.
A double-blind, placebo-controlled, 24-hour post dose continuous monitoring, crossover study in 47 subjects evaluated the effect of 0.2 mmol/kg MultiHance on ECG intervals, including QTc. The average changes in QTc values compared with placebo were minimal (< 5 msec). QTc prolongation between 30 and 60 msec were noted in 20 subjects who received MultiHance vs. 11 subjects who received placebo. Prolongations ≥ 61 msec were noted in 6 subjects who received MultiHance and in 3 subjects who received placebo. None of these subjects had associated malignant arrhythmias. The effects on QTc by MultiHance dose, other drugs, and medical conditions were not systematically studied.
Certain lesions seen on non-contrast images may not be seen on contrast- images. Exercise caution when interpreting contrast MR images in the absence of companion non-contrast MR images.
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
In clinical trials, a total of 2982 adult subjects (119 healthy volunteers and 2863 patients) received MultiHance at doses ranging from 0.005 to 0.4 mmol/kg. There were 1724 (58%) men and 1258 (42%) women with a mean age of 55.1 years (range 18 to 92 years). A total of 2644 (89%) subjects were Caucasian, 84 (3%) Black, 162 (5%) Asian, 29 (1%) Hispanic, 18 (1%) in other racial groups, and for 45 (2%) subjects, race was not reported.
The most commonly reported adverse reactions in adult subjects who received MultiHance were headache (1.8%) and nausea (1.6%). Most adverse reactions were mild to moderate in intensity. Four subjects experienced serious adverse reactions. One subject with a history of seizures experienced convulsions 17 minutes after the administration of MultiHance. Another subject with a history of recent myocardial infarction (MI) and congestive heart failure (CHF) experienced acute pulmonary edema within 10 minutes after the administration of 30 mL of MultiHance. The third subject developed acute necrotizing pancreatitis. The fourth subject experienced an anaphylactoid reaction with laryngismus and dyspnea [ see Warnings and Precautions (5.2) ].
Adverse reactions that occurred in at least 0.5% of 2982 adult subjects who received MultiHance are listed below (Table 1), in decreasing order of occurrence within each system.
The following adverse reactions occurred in less than 0.5% of the 2982 adult subjects who received MultiHance:
Blood and Lymphatic System Disorders: Basophilia, decreased hemoglobin, hemolysis, leukocytosis, leukopenia;
Cardiac Disorders: Arrhythmia, atrial fibrillation, bradycardia, chest discomfort, ECG abnormality (bundle branch block, complete AV block, first-degree AV block, inverted T wave, prolonged PR interval, prolonged QT interval, shortened QT interval), myocardial ischemia, palpitations, supraventricular extrasystoles, tachycardia, ventricular arrhythmia, ventricular extrasystoles;
Ear and Labyrinth Disorders: Ear pain, tinnitus;
Eye Disorders: Eyelid edema, ocular hyperemia, visual disturbance;
Gastrointestinal Disorders: Acute necrotizing pancreatitis, abdominal pain, constipation, diarrhea, dry mouth, dyspepsia, fecal incontinence, increased pruritus in patients with cirrhosis, vomiting;
General Disorders and Administration Site Conditions: Asthenia, back pain, chest pain, chills, fever, infection, injection site extravasation, injection site inflammation, injection site pain, malaise, rigors;
Immune System Disorders: Anaphylactic and anaphylactoid reactions, anaphylactic shock, hypersensitivity reactions;
Investigations: Abnormal laboratory test (includes changes in CPK, creatinine, ferritin, transferrin, total iron binding capacity), bilirubinemia, hyperglycemia, hyperkalemia, hypocalcemia, hypoglycemia, hyponatremia, decreased blood albumin, increased alkaline phosphatase, increased GGT, increased LDH, increased serum iron, increased SGOT, increased SGPT;
Musculoskeletal and Connective Tissue Disorders: Muscle spasms, myalgia, myositis;
Nervous System Disorders: Aphasia, convulsion, hemiplegia, hypertonia, hypoesthesia, paralysis, parosmia, stupor, syncope, tremor;
Renal and Urinary Disorders: Albuminuria, glycosuria, hematuria, proteinuria, urinary frequency, urinary tract infection;
Respiratory, Thoracic and Mediastinal Disorders: Acute pulmonary edema, cough, dyspnea, hyperventilation, laryngospasm, nasal congestion, obstructive airway disorder, pulmonary embolus, wheezing;
Skin and Subcutaneous Tissue Disorders: Facial edema, hyperhidrosis, pruritus, sweating, urticaria;
Vascular Disorders: Hypotension.
In clinical trials, 217 pediatric subjects received MultiHance at a dose of 0.1 mmol/kg. A total of 112 (52%) subjects were male and the overall mean age was 8.3 years (range 4 days to 17 years). A total of 168 (77%) subjects were Caucasian, 12 (6%) Black, 12 (6%) Asian, 24 (11%), Hispanic, and 1 (<1%) in other racial groups.
Adverse reactions were reported for 14 (6.5%) of the subjects. The frequency and the nature of the adverse reactions were similar to those seen in the adult patients. The most commonly reported adverse reactions were vomiting (1.4%), pyrexia (0.9%), and hyperhidrosis (0.9%). No subject died during study participation. A serious adverse reaction of worsening of vomiting was reported for one (0.5%) patient with a brain tumor (glioma) for which a causal relationship to MultiHance could not be excluded.
|Number of subjects dosed
|Number of subjects with any adverse reaction
|450 (15.1%)
|Gastrointestinal Disorders
|48 (1.6%)
|14 (0.5%)
|General Disorders and Administration Site Disorders
|Feeling Hot
|31 (1.0%)
|Injection Site Reaction
|40 (1.3%)
|Nervous System Disorders
|54 (1.8%)
|Taste perversion
|25 (0.8%)
|23 (0.8%)
|22 (0.7%)
|Skin and Subcutaneous Tissue Disorders
|19 (0.6%)
|Vascular Disorders
|16 (0.5%)
The following adverse reactions have been identified during post approval use of MultiHance. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Anaphylactic, anaphylactoid and hypersensitivity reactions manifested with various degrees of severity up to anaphylactic shock, loss of consciousness and death. The reactions generally involved signs or symptoms of respiratory, cardiovascular, and/or mucocutaneous abnormalities. Extravasation of MultiHance may lead to injection site reactions, characterized by local pain or burning sensation, swelling, blistering, and necrosis [ see Warnings and Precautions (5.4) ].
MultiHance and other drugs may compete for the canalicular multispecific organic anion transporter (MOAT also referred to as MRP2 or ABCC2). Therefore MultiHance may prolong the systemic exposure of drugs such as cisplatin, antracyclines (e.g. doxorubicin, daunorubicin), vinca alkaloids (e.g. vincristine), methotrexate, etoposide, tamoxifen, and paclitaxel. In particular, consider the potential for prolonged drug exposure in patients with decreased MOAT activity (e.g. Dubin Johnson syndrome).
Pregnancy Category C.
MultiHance has been shown to be teratogenic in rabbits when given intravenously administered at 2 mmol/kg/day (6 times the human dose based on body surface area) during organogenesis (day 6 to 18) inducing microphthalmia/small eye and/or focal retinal fold in 3 fetuses from 3 separate litters. In addition, MultiHance intravenously administered at 3 mmol/kg/day (10 times the human dose based on body surface area) has been shown to increase intrauterine deaths in rabbits. There was no evidence that MultiHance induced teratogenic effects in rats at doses up to 2 mmol/kg/day (3 times the human dose based on body surface area), however, rat dams exhibited no systemic toxicity at this dose. There were no adverse effects on the birth, survival, growth, development and fertility of the F1 generation at doses up to 2 mmol/kg in a rat peri- and post-natal (Segment III) study. There are no adequate and well-controlled studies in pregnant women. MultiHance should be used during pregnancy only if potential benefit justifies the potential risk to the fetus.
It is not known to what extent gadobenate dimeglumine is excreted in human milk. It is known from rat experiments that less than 0.5% of the administered dose is transferred via milk from mother to neonates. Breast-feeding should be discontinued prior to the administration of MultiHance and should not be restarted until at least 24 hours after the administration of MultiHance.
A total of 217 pediatric subjects (93% of subjects aged 2 years and above) were studied in clinical trials. No overall differences in safety or effectiveness were observed between these pediatric subjects and the adult subjects. The safety and efficacy of MultiHance in neonates and infants (ages 0-2 years) have not been established. The risk of NSF related to gadolinium may be increased in these patients due to their immature kidney function.
Of the total number of 2982 adult subjects in clinical studies of MultiHance, 27% were 65 and over. No overall differences in safety or effectiveness were observed between these elderly subjects and the younger subjects.
The drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to MultiHance may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function it may be useful to monitor renal function.
Clinical consequences of overdosage with MultiHance have not been reported. Treatment of an overdosage should be directed toward support of vital functions and prompt institution of symptomatic therapy. In a Phase 1 clinical study, doses up to 0.4 mmol/kg were administered to patients. MultiHance has been shown to be dialyzable [ see Clinical Pharmacology (12.3) ].
MultiHance injection is supplied as a sterile, nonpyrogenic, clear, colorless, aqueous solution intended for intravenous use only. Each mL of MultiHance contains 529 mg gadobenate dimeglumine and water for injection. MultiHance contains no preservatives.
Gadobenate dimeglumine is chemically designated as (4RS)-[4-carboxy-5,8,11-tris(carboxymethyl)- 1-phenyl-2-oxa-5,8,11-triazatridecan-13-oato(5-)] gadolinate(2-) dihydrogen compound with 1-deoxy-1-(methylamino)-D-glucitol (1:2) with a molecular weight of 1058.2 and an empirical formula of CHGdNO • 2CHNO. The structural formula is as follows:
MultiHance has a pH of 6.5-7.5. Pertinent physicochemical parameters are provided below:
MultiHance has an osmolality 6.9 times that of plasma (285 mOsmol/kg water) and is hypertonic under conditions of use.
|1.970 osmol/kg @ 37°C
|5.3 mPas @ 37°C
|1.220 g/mL @ 20°C
Gadobenate dimeglumine is a paramagnetic agent and, as such, develops a magnetic moment when placed in a magnetic field. The large magnetic moment produced by the paramagnetic agent results in a large local magnetic field, which can enhance the relaxation rates of water protons in its vicinity leading to an increase of signal intensity (brightness) of tissue.
In magnetic resonance imaging (MRI), visualization of normal and pathological tissue depends in part on variations in the radiofrequency signal intensity that occur with 1) differences in proton density; 2) differences of the spin-lattice or longitudinal relaxation times (T1); and 3) differences in the spin-spin or transverse relaxation time (T2). When placed in a magnetic field, gadobenate dimeglumine decreases the T1 and T2 relaxation time in target tissues. At recommended doses, the effect is observed with greatest sensitivity in the T1-weighted sequences.
Unlike other tested paramagnetic contrast agents (See Table 2), MultiHance demonstrates weak and transient interactions with serum proteins that causes slowing in the molecular tumbling dynamics, resulting in strong increases in relaxivity in solutions containing serum proteins. The improved relaxation effect can contribute to increased contrast-to-noise ratio and lesion-to-brain ratio, which may improve visualization.
MultiHance injection does not cross the intact blood-brain barrier and, therefore, does not enhance normal brain or lesions that have a normal blood-brain barrier, e.g., cysts, mature post-operative scars. However, disruption of the blood-brain barrier or abnormal vascularity allows enhancement by MultiHance of lesions such as neoplasms, abscesses, and infarcts. Uptake of MultiHance into hepatocytes has been demonstrated.
|r1 and r2 relaxivities indicate the efficiency in shortening T1 and T2 relaxation times, respectively.
|1 In heparinized human plasma, at 39°C.
|2 In citrated human plasma, at 37°C.
|-- Not available
|Human plasma
Three single-dose intravenous studies were conducted in 32 healthy male subjects to assess the pharmacokinetics of gadobenate dimeglumine. The doses administered in these studies ranged from 0.005 to 0.4 mmol/kg. Upon injection, the meglumine salt is completely dissociated from the gadobenate dimeglumine complex. Thus, the pharmacokinetics is based on the assay of gadobenate ion, the MRI contrast effective ion in gadobenate dimeglumine. Data for plasma concentration and area under the curve demonstrated linear dependence on the administered dose. The pharmacokinetics of gadobenate ion following intravenous administration can be best described using a two-compartment model.
Distribution Gadobenate ion has a rapid distribution half-life (reported as mean ± SD) of 0.084 ± 0.012 to 0.605 ± 0.072 hours. Volume of distribution of the central compartment ranged from 0.074 ± 0.017 to 0.158 ± 0.038 L/kg, and estimates of volume of distribution by area ranged from 0.170 ± 0.016 to 0.282 ± 0.079 L/kg. These latter estimates are approximately equivalent to the average volume of extracellular body water in man. In vitro studies showed no appreciable binding of gadobenate ion to human serum proteins.
Elimination Gadobenate ion is eliminated predominately via the kidneys, with 78% to 96% of an administered dose recovered in the urine. Total plasma clearance and renal clearance estimates of gadobenate ion were similar, ranging from 0.093 ± 0.010 to 0.133 ± 0.270 L/hr/kg and 0.082 ± 0.007 to 0.104 ± 0.039 L/hr/kg, respectively. The clearance is similar to that of substances that are subject to glomerular filtration. The mean elimination half-life ranged from 1.17 ± 0.26 to 2.02 ± 0.60 hours. A small percentage of the administered dose (0.6% to 4%) is eliminated via the biliary route and recovered in feces.
Metabolism There was no detectable biotransformation of gadobenate ion. Dissociation of gadobenate ion in vivo has been shown to be minimal, with less than 1% of the free chelating agent being recovered alone in feces.
Pharmacokinetics in Special Population
Renal Impairment: A single intravenous dose of 0.2 mmol/kg of MultiHance was administered to 20 subjects with impaired renal function (6 men and 3 women with moderate renal impairment [urine creatinine clearance >30 to <60 mL/min] and 5 men and 6 women with severe renal impairment [urine creatinine clearance >10 to <30 mL/min]). Mean estimates of the elimination half-life were 6.1 ± 3.0 and 9.5 ± 3.1 hours for the moderate and severe renal impairment groups, respectively as compared with 1.0 to 2.0 hours in healthy volunteers.
Hemodialysis: A single intravenous dose of 0.2 mmol/kg of MultiHance was administered to 11 subjects (5 males and 6 females) with end-stage renal disease requiring hemodialysis to determine the pharmacokinetics and dialyzability of gadobenate. Approximately 72% of the dose was recovered by hemodialysis over a 4-hour period. The mean elimination half-life on dialysis was 1.21 ± 0.29 hours as compared with 42.4 ± 24.4 hours when off dialysis.
Hepatic Impairment: A single intravenous dose of 0.1 mmol/kg of MultiHance was administered to 11 subjects (8 males and 3 females) with impaired liver function (Class B or C modified Child-Pugh Classification). Hepatic impairment had little effect on the pharmacokinetics of MultiHance with the parameters being similar to those calculated for healthy subjects.
Gender, Age, Race: A multiple regression analysis performed using pooled data from several pharmacokinetic studies found no significant effect of sex upon the pharmacokinetics of gadobenate. Clearance appeared to decrease slightly with increasing age. Since variations due to age appeared marginal, dosage adjustment for geriatric population is not recommended. Pharmacokinetic differences due to race have not been systematically studied.
Pediatric: A population pharmacokinetic analysis incorporated data from 25 healthy subjects (14 males and 11 females) and 15 subjects undergoing MR imaging of the central nervous system (7 males and 8 females) between ages of 2 and 16 years. The subjects received a single intravenous dose of 0.1 mmol/kg of MultiHance. The geometric mean C was 62.3 µg/mL (n=16) in children 2 to 5 years of age, and 64.2 µg/mL (n=24) in children older than 5 years. The geometric mean AUC was 77.9 µg-h/mL in children 2-5 years of age (n=16) and 82.6 µg-h/mL in children older than 5 years (n=24). The geometric mean half-life was 1.2 hours in children 2 to 5 years of age and 0.93 hours in children older than 5 years. There was no significant gender-related difference in the pharmacokinetic parameters in the pediatric patients. Over 80% of the dose was recovered in urine after 24 hours.
Long-term animal studies have not been performed to evaluate the carcinogenic potential of MultiHance.
The results for MultiHance were negative in the following genetic toxicity studies: 1) in vitro bacteria reverse mutation assays, 2) an in vitro gene mutation assay in mammalian cells, 3) an in vitro chromosomal aberration assay, 4) an in vitro unscheduled DNA synthesis assay, and 5) an in vivo micronucleus assay in rats.
MultiHance had no effect on fertility and reproductive performance at IV doses of up to 2 mmol/kg/day (3 times the human dose on body surface basis) for 13 weeks in male rats and for 32 days in female rats. However, vacuolation in testes and abnormal spermatogenic cells were observed when MultiHance was intravenously administered to male rats at 3 mmol/kg/day (5 times the human dose on body surface basis) for 28 days. The effects were not reversible following 28-day recovery period. The effects were not reported in dog and monkey studies (at doses up to about 11 and 10 times the human dose on body surface basis for dogs (28 days dosing) and monkeys (14 days dosing), respectively).
MultiHance was evaluated in 426 adult patients in 2 controlled clinical trials of the central nervous system (Study A and Study B), enrolling 217 men and 209 women with a mean age of 52 years (range 18 to 88 years). The racial and ethnic representations were 88% Caucasian, 6% Black, 4% Hispanic, 1% Asian, and 1% other racial or ethnic groups. These trials were designed to compare MultiHance contrast MRI to non-contrast MRI alone. In Study A, patients highly suspected of having a lesion(s) of the CNS based on nuclear medicine imaging, computed tomography (CT), contrast CT, MRI, contrast- MRI, or angiography were randomized to receive two MRI evaluations with 0.05 mmol/kg (n=140) or 0.1 mmol/kg (n=136) of MultiHance. In Study B, patients with known metastatic disease to the CNS were randomized to receive two MRI evaluations with 0.05 mmol/kg (n=74) or 0.1 mmol/kg (n=76) of MultiHance. MRI scans were performed pre-contrast and within 5 minutes after each injection. The studies were designed to evaluate the effect of MultiHance MRI compared to the non-contrast MRI on a lesion level. Pre-contrast, post-contrast, and pre-plus-post contrast images (paired images) were independently evaluated by three blinded readers. The images were evaluated for the following endpoints using a scale from 0 to 4: the degree of lesion border delineation, the degree of visualization of lesion internal morphology, and the degree of lesion contrast enhancement. Lesion counting was also performed for the pre-contrast and paired image sets.
The 0.1 mmol/kg dose of MultiHance demonstrated consistently better visualization for all readers for all visualization endpoints. However, the 0.05 mmol/kg dose of MultiHance provided inconsistent visualization results between readers.
Comparison of pre-contrast versus post-contrast (0.1 mmol/kg) images showed that the mean score differences were significant and favored contrast for subjects in Study B (all subjects with known metastatic lesions) and for subjects with known tumors in Study A. However, the mean score differences between the pre-contrast and post-contrast images were not significant for non-tumor patients in Study A. These negative results may be attributed to a lack of lesion enhancement in non-tumor CNS disease.
Table 3 shows a comparison of paired images (pre-and post-contrast) versus pre-contrast images with respect to the difference in the mean score and with respect to the proportion of lesions read as better, worse, or the same as the pre-contrast MRI images. Table 3 shows that based on a lesion-level analysis 0.1 mmol/kg MultiHance provided a statistically significant improvement for the three structural parameters evaluated. Also, more lesions were seen in the paired images than in the pre-contrast images alone.
The efficacy and safety of MultiHance were evaluated in 92 pediatric patients with known or highly suspected disease of the central nervous system. MRI scans were performed pre-contrast and within 3 to 10 minutes following the administration of MultiHance 0.1 mmol/kg. Pre-contrast, post-contrast, and pre-plus-post contrast images (paired images) were independently evaluated by three blinded readers on a lesion level. The images were evaluated for the same endpoints as in the adult central nervous system trials using a scale from 0 to 4: the degree of lesion border delineation, the degree of visualization of lesion internal morphology, and the degree of lesion contrast enhancement. Lesion counting was also performed for the pre-contrast and paired image sets. The pre-contrast versus the paired image set was the primary comparison. Forty-nine percent of study subjects were male and the overall mean age was 10.6 years (range 2 to 17 years). The racial and ethnic representations were 77% Caucasian, 13% Asian, 5% Black, and 4% other racial or ethnic groups. MultiHance increased lesion border delineation, lesion internal morphology, and lesion contrast enhancement relative to non-contrast and these results were comparable to those seen in adults.
|Study A
|Study B
|(a) Difference of means = (paired mean) - (pre mean)
|(b) Worse = paired score is less than the pre score
Same = paired score is the same as the pre score
Better = paired score is greater than the pre score
|* Statistically significant for the mean (paired t test)
|Reader 1
|Reader 2
|Reader 3
|Reader 1
|Reader 2
|Reader 3
|Border Delineation:
|Difference of Means (a)
|Worse (b)
|44 (11%)
146 (37%)
205 (52%)
|61 (16%)
168 (44%)
155 (40%)
|57 (19%)
89 (30%)
153 (51%)
|13 (5%)
11 (5%)
221 (90%)
|24 (9%)
19 (7%)
232 (84%)
|15 (6%)
18 (7%)
221 (87%)
|Internal Morphology:
|Difference of Means
|37 (10%)
147 (37%)
211 (53%)
|63 (17%)
151 (39%)
170 (44%)
|62 (21%)
84 (28%)
153 (51%)
|13 (5%)
16 (7%)
216 (88%)
|26 (10%)
22 (8%)
227 (82%)
|14 (5%)
22 (9%)
218 (86%)
|Contrast Enhancement:
|Difference of Means
|75 (19%)
148 (37%)
172 (44%)
|74 (19%)
152 (40%)
158 (41%)
|50 (17%)
109 (36%)
140 (47%)
|13 (5%)
11 (5%)
221 (90%)
|32 (12%)
21 (7%)
222 (81%)
|17 (7%)
14 (5%)
223 (88%)
How Supplied
MultiHance (gadobenate dimeglumine) is a clear, colorless solution containing 529 mg gadobenate dimeglumine per mL. MultiHance is supplied in glass vials; each single dose vial is rubber stoppered with an aluminum seal and the contents are sterile. MultiHance is supplied in boxes of:
Five 5 mL single dose 10 mL vials (NDC 0270-5164-12) Five 10 mL single dose 20 mL vials (NDC 0270-5164-13) Five 15 mL single dose 20 mL vials (NDC 0270-5164-14) Five 20 mL single dose 20 mL vials (NDC 0270-5164-15)
Storage and Handling Inspect the MultiHance vial visually for particulate matter and discoloration prior to administration. Do not use the solution if it is discolored or particulate matter is present. Do not mix intravenous medications or parenteral nutrition solutions with MultiHance. Do not administer other medications in the same intravenous line with MultiHance because of the potential for chemical incompatibility.
Draw MultiHance into a syringe and inject using sterile technique. MultiHance vials are intended for single use only. Administer immediately after opening and discard any unused product.
Store at 25°C (77°F), excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]. Do not freeze.
Instruct patients to inform their physician if they:
GBCAs increase the risk for NSF among patients with impaired elimination of the drugs. To counsel patients at risk for NSF:
Instruct the patients to contact their physician if they develop signs or symptoms of NSF following MultiHance administration, such as burning, itching, swelling, scaling, hardening and tightening of the skin; red or dark patches on the skin; stiffness in joints with trouble moving, bending or straightening the arms, hands, legs or feet; pain in the hip bones or ribs; or muscle weakness.
Inform patients that they may experience:
Instruct patients scheduled to receive MultiHance to inform their physician if they:
US Patent No. 4,916,246
Manufactured for Bracco Diagnostics Inc. - Princeton, NJ 08543 By BIPSO GmbH - 78224 Singen (Germany)
Revised July 2011
Multihance Injection 10 mL NDC 0270-5164-13
Multihance [Bracco Diagnostics Inc]
These highlights do not include all the information needed to use MultiHance safely and effectively. See full prescribing information for MultiHance. MultiHance (gadobenate dimeglumine) injection Init...
Multihance [Bracco Diagnostics Inc]
Multihance Multipack (gadobenate dimeglumine) injection, 529 mg/mL
These highlights do not include all the information needed to use OMNISCAN safely and effectively. See full prescribing information for OMNISCAN.OMNISCAN™ (gadodiamide) Injection for Intravenous Use...
Multihance at 3 Tesla in Brain Tumors
The purpose of this study is to evaluate whether Multihance is superior to Magnevist in terms of qualitative and quantitative assessment of unenhanced MRI and contrast-enhanced MRI for the...
Assessment of Liver Cancer Response to TACE Using MultiHance-Enhanced MRI
This research is being done to find out if using the contrast agent MultiHance can be used to show how a liver tumor responds to the chemotherapy given during Transcatheter Arterial Chemoe...
Study to Compare MultiHance With Gadovist in Magnetic Resonance Imaging (MRI) of the Brain
This study is being conducted as a phase IV, double-blind, multi-center, randomized, crossover trial aimed at a within-subject comparison of MULTIHANCE and GADOVIST at a dose of 0.1 mmol/k...
Retrospective Study of MRI With MULTIHANCE at 0.10 and 0.05 mmol/Kg Dose in CNS Patients
This is a retrospective study to collect already existing data and images from patients ≥ 2 years of age who had MRI for CNS diseases with MultiHance administration at a standard 0.10 mm...
A Pharmacokinetics Study of MultiHance in Pediatric Patients
Compare relative exposure in the younger age group in order to supplement the PK profile already determined in older children and adults
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In addition to all of the services you expect (moorings, pumpout, fuel, gas, etc, Fazeley Mill marina also offers wifi .
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Southampton Liverpool is a Semi finals match. The live Southampton Liverpool match starts at 19:45 on 11 january 2017. You can follow coverage of the Southampton Liverpool match and scores in real time and receive live alerts (goals, bookings, who scored and penalties). At full-time, find all the highlights of the Southampton Liverpool result on this page.
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By exits, I mean the equivalent of getting out of the mainstream of the defined process and being able to address an exception directly. In my case, the fact that I called more than once about the same issue should have been an indication that the process, or its execution, was not producing intended outcomes. Lets be clear, its preferable to follow an established process when it makes sense, but when exceptions occur the process needs to be resilient enough to handle them, and if too many exceptions occur, thats probably an indication of a larger issue.
The takeaway for organizations and BPO providers is to mutually define how intended outcomes can be tested and then to do so. That means actually poking at the process by simulating not only expected usage but whether the process is resilient enough to handle the unexpected and still achieve intended outcomes.
I spoke in my last column about the irony of getting customer satisfaction surveys from the technology supplier, contact center and collections function as result of my buying experience. The irony is derived from these surveys because they contained information that had to be shared between all three entities, yet they couldnt share any information that would have helped solve the problem.
Undaunted, I returned all the surveys along with detailed accounts of what happened and suggestions on how to fix the problems I perceived to exist. Guess what kind of response I got? Nothing, nada, null, zip. For one of them, not even an indication the message got through. Would you feel like theyre serious about intended outcomes?
Heres another scenario I encountered recently: On vacation with my family, we stayed in the mid-scale brand of a relatively well-known hotel chain. My kids were looking forward to using the pool, and when I confirmed my reservation at the front desk no one mentioned any issues, but when we arrived I found it was being renovated. Although annoying, we found other activities to placate the kids and avert a riot.
I provided feedback about this on the hotels Web site and waited. Less than 24 hours later, I had an apology from the property manager and her supervisor, a voucher to apply toward a future stay in any other property within the hotels brands, and double my rewards points for my stay. The organizations contact center is outsourced, yet their process and information integration enabled them to address the issue efficiently and effectively. I even received an email thanking me for helping to make the organization better, and asking whether I was satisfied.
Thats what I call serious.
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The rolling green hills and wild woods of central Italy: a feast of dark, rich, sensuous scents from trees, undergrowth, sap and natural resins. Top notes of cognac, calamus and wild carrot seed lead into a rich dark heart of tobacco, copahu, opoponax, orris root and patchouli. Oil of vetiver adds to the sense of forests and verdance.


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In this Sliding and Shower Tub Enclosure Bumper Assortment you receive two large 3/4 inch (19 millimeter), and two small 1/2 inch (12.7 millimeter) square white rubber bumpers. These bumpers have pressure sensitive adhesives eliminating the need for screws. They provide anti-slam protection for sliding shower and tub enclosure doors.
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Vu Thao is a clothing designer who seamlessly merges contemporary silhouettes with traditional Vietnamese techniques of natural dyeing, beeswax printing, hand quilting and embroidery. She collaborates with ethnic minority women from the northern mountains of Vietnam to grow and produce natural dyes from indigo, yam and magenta plants – and fibers from organic cotton and hemp – then weaves her own fabrics for her designs. For buttons and other trimmings, she uses natural materials like nuts, wood, coal, stone, bamboo and bone. She finds design inspiration in her eclectic collection of traditional costumes, natural materials and indigenous artifacts that fill her studio. Sophisticated and stylish, Thao is a self-confessed culture lover.
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