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Recent genome-wide association studies have identified a single nucleotide polymorphism within the last intron of MAP2K5 associated with a higher body mass index (BMI) in adults. MAP2K5 is a component of the MAPK-family intracellular signaling pathways, responding to extracellular growth factors such as brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF). In this study, we examined the association of this variant in two cohorts of children from Sweden and Greece.
We examine the association of rs2241423 to BMI in a cohort of 474 Swedish children admitted for treatment of childhood obesity and 519 children matched for gender, ethnicity and socioeconomic background from the Stockholm area, as well as a cross-sectional cohort of 2308 Greek school children (Healthy Growth Study). Children were genotyped using a predesigned TaqMan polymorphism assay. Logistic regression was used to test for an association of rs2241423 to obesity in the cohort of Swedish children. Linear regression was used to test for an association of rs2241423 to BMI z-score and phenotypic measurements of body adiposity in the cohort of Greek children. Models were adjusted for age and gender. In the cohort of Greek children the model was also adjusted for stage of pubertal development.
The minor allele of rs2241423, allele A, was associated with a protective effect against obesity in the cohort of Swedish children (p=0.029, OR=0.79 (95% CI: 0.64–0.98)), and with a lower BMI z-score in the cohort of Greek children (p=0.028, β=−0.092). No association to phenotypic measurements of body fat distribution could be observed in our study.
rs2241423 was associated with BMI and obesity in two independent European cohorts suggesting a role for MAP2K5 in early weight regulation.
A strong genetic component has been shown to underlie the development of common polygenic obesity, one of the most serious medical problems facing industrialized societies today. Over the last decade, large scale genome wide association studies (GWAs) have identified some of the genetic variants associated with obesity. A recent report from the GIANT-consortium, a meta-analysis of GWAs on a total of nearly 250000 individuals, identified 32 loci associated with an increased risk of developing obesity [1]. The GIANT consortium also reported directionally consistent effects of rs2241423 in meta-analyses of the cohorts containing children included in the main analysis [1]. However, a statistically significant effect was observed in the meta-analysis of extremely obese case–control association studies (n=15 250) and transmission disequilibrium tests (TDT) (n=1 460), but not in the meta-analysis of population-based studies (n=1 460) [1]. Variations in the gene encoding the dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5) were subsequently identified as risk factors for obesity in a meta-analysis of data from five cohorts of Chinese, Malay and Indian descent (total n=10 482) [2]. In this study, the strongest association to BMI was identified as the major allele of the single nucleotide polymorphism (SNP) rs2241423 located in the last intron of the MAP2K5 gene and in proximity of the gene encoding SKI family transcriptional corepressor 1 (SKOR1) (Figure1, Additional file 1: Figure S1).
This locus has previously been associated with the restless legs syndrome (RLS) [3], a condition defined by an urge to move the legs often accompanied by uncomfortable or unpleasant sensations in the legs temporarily relieved during movement. The symptoms of RLS often worsen during periods of rest and can cause difficulties falling asleep as well as sleep disruptions which can seriously affect quality of life [4]. Common hereditary factors between RLS and obesity have also previously been suggested [5].
MAP2K5 has been extensively studied as it is a component of the MAPK-family intracellular signaling pathways, responding to extracellular growth factors such as brain derived neurotrophic factor (BDNF), nerve growth factor (NGF) (Kyoto Encyclopedia of Genes and Genomes, KEGG [6]), insulin-like growth factor 2 (IGF2) [7], granulocyte colony-stimulating factor [8] as well as epidermal growth factor [9]. This pathway also responds to shear stress [10] and osmotic stress. MAP2K5 is a 20 exon gene spanning about 280kbp. It encodes three known protein-coding transcripts, one of which MEKα, is expressed in the liver and the brain to a higher degree [11] where it acts to phosphorylate and activate extracellular signal regulated kinase 5 (ERK5) which in turn activates transcription factors, also via phosphorylation, leading to cell differentiation and proliferation [12]. MEKβ on the other hand is ubiquitously expressed but does not activate ERK5. MEKβ has instead been suggested to act as an inhibitor of ERK5-activation via competitive binding, and to inhibit cell growth in terminally differentiated cell types.
Rs2241423 is furthermore located 30kb upstream of the gene encoding SKOR1. SKOR1 is a transcriptional co-repressor which acts by inhibiting gene expression induced by bone morphogenetic (BMP) family growth factors [13,14]. In humans, SKOR1 is mainly expressed in the adult cerebellum [14], but it may play a more important role as an induced repressor of gene transcription and subsequent cellular differentiation during early central nervous system (CNS) development. Mouse studies have shown this gene to be important for determining cell fate in the developing CNS [14,15]. SKOR1 is also involved in wound healing [13].
In this study we aim to further explore the association of the MAP2K5-linked SNP, rs2241423, to obesity and BMI in two cohorts of Swedish and Greek children. The high allele frequency of rs2241423, and the effects observed in meta-analysis of child cohorts by the GIANT consortium, makes it a good candidate for association studies in our cohorts. We also tested for an association to phenotypic variables describing body fat distribution in the cohort of Greek children, with the aim to specify the effect carried by the genetic variant. Identification and replication of genetic factors underlying pediatric obesity is also of great interest as genetic variants can have differential effects on early-onset and adult obesity. Rs2241423 was genotyped in two cohorts: one consisting of 474 children admitted to the pediatric clinic for treatment of childhood obesity at the National Childhood Obesity Centre, Karolinska University Hospital, Sweden, as well as an age- and gender-matched control population of 519 children from the same area; and one cohort of 2308 children from primary schools in the Athens-region, Greece. We also tested the association of rs2241423 to phenotypic measurements of body-fat distribution in the cohort of Greek children.
Genotyping of rs2241423 was performed on 993 children and adolescents comprising two study groups as described earlier [16,17]. Briefly, one group of 474 obese children and adolescents (250 girls and 224 boys, age 6–21years) enrolled at National Childhood Obesity Centre at the Karolinska University Hospital, Huddinge, Sweden and one group of 519 normal weight Swedish adolescents (267 girls and 252 boys, age 15–20years) recruited from 17 upper secondary schools around Stockholm and matched to the obese group with respect to ethnicity and socioeconomic status (Table1). Subjects with overweight/obesity or chronic diseases were excluded from the group of normal weight adolescents, and subjects with type 2 diabetes and known related subjects were excluded from the obese group. BMI was calculated from height and weight and body mass index standard deviation score (BMISDS) was calculated from weight and height and standardized for age and gender. Subjects with overweight/obesity or chronic diseases were excluded from the group of normal weight adolescents, and subjects with type 2 diabetes were excluded from the obese group. The study was approved by the Regional Committee of Ethics, Stockholm. Informed consent was provided by all participants or by their legal guardians.
The cohort of Greek children was comprised of 2658 schoolchildren, attending the 5th and 6th grades of primary schools (Table1) and participating in the "Healthy Growth Study", a large scale, cross-sectional and epidemiological study initiated in May 2007 as described previously [19,20]. An extended letter explaining the aims of the current study and a consent form were provided to each parent who had a child in one of the primary schools participating in the study. Those parents who agreed to participate in the study gave their informed consent by signing the consent form, and provided their contact details. Body weight and height were measured in all study participants using standard procedures and equipment. Body weight was measured to the nearest 10g and height was measured to the nearest 0.1cm in standing position. BMI z-score was calculated relative to the International Obesity Task Force (IOTF) definitions [21]. Waist and hip circumference was measured to the nearest 0.1cm with the use of a non-elastic tape (Hoechstmass, Sulzback, Germany). Measurements were taken with the subject at a standing position, around the trunk, at the level of umbilicus midway between the lower rib margin and the iliac crest. The thickness of four skinfolds (triceps, biceps, subscapular and suprailiac) was measured to the nearest 0.1mm to the right side of the body with a Lange skinfold caliper (Cambridge, Maryland). Each skinfold was grasped gently, in order to avoid causing any unnecessary discomfort to the child. Triceps and biceps skinfold thickness was measured with the right arm hanging relaxed at the side of the body while the skinfold was picked up about 1cm bellow the midpoint mark over the triceps and biceps muscle respectively. Measurement of the subscapular skinfold thickness was performed while the child stood with shoulders relaxed and after identifying the inferior angle of the scapula. The skinfold was picked up 1cm below the subscapular mark. Suprailiac skinfold was measured just above the iliac crest, along the axis of the anterior line. In each case the caliper was applied to the "neck" of the fold just above the finger and thumb, for two repeated measurements. Four well-trained and experienced female pediatricians determined pubertal maturation (Tanner Stage) after a thorough inspection [22]. Breast development in girls and genital development in boys was used for pubertal maturation classification (Tanner stages 1 to 5). DNA for genotyping was available for 2308 individuals (1163 males and 1145 females). Approval to the study was granted by the Greek ministry of Education and the Ethical Committee of Harokopio University of Athens. Informed consent was provided by all participants or by their legal guardians.
Genotyping of rs2241423 was carried out with a pre-designed Taqman single-nucleotide polymorphism genotyping assay (Applied Biosystems, Foster City, USA) and an ABI7900 genetic analyzer with SDS 2.2 software at the Uppsala Genome Center (http://www.genpat.uu.se/node462). The genotype call rate was 97.8% in the Swedish cohort and 99.0% in the Greek cohort. Tests for deviation from Hardy-Weinberg equilibrium were performed using a Markov chain Monte Carlo test [23] in PLINK [24]. No deviations from Hardy-Weinberg equilibrium were detected for rs2241423 in the Swedish and Greek cohorts.
Haploview [25] was used to generate a graphical representation of the linkage disequilibrium (LD) structure from r2 scores. The LD pattern was generated using HapMap data version 3, release 2 and CEU+TSI as analysis panel (Additional file 1: Figure S1).
Association with obesity was analyzed using logistic regression in the Swedish cohort comparing children diagnosed as obese at the Huddinge Childhood Obesity Centre to normal weight controls recruited from the same region. Association was presented as an odds ratio (OR) with 95% confidence interval (CI) (Table2). Gender was accounted for in the analysis. Linear regression analysis was used to ascertain association between rs2241423 and BMI and body adiposity measurements in the Greek cohort. Skewed quantitative variables were normalized by logarithmic transformation before analysis. Models were adjusted for age, gender, BMI and stage of pubertal development: tanner-stage [26]. Statistical analyses were performed with PLINK (http://pngu.mgh.harvard.edu/purcell/plink/) [24] assuming an additive model. Given the prior information about the role of MAP2K5 variation in obesity, the evaluation of the association with BMI and obesity is considered a replication study; thus, nominal p values≤0.05 were considered significant. For obesity related phenotypes in the Greek cohort not previously studied, we applied a Bonferroni correction and p-value <0.007 were considered statistical significant.
Power calculations were carried out with the CaTS power calculator (http://www.sph.umich.edu/csg/abecasis/CaTS) [27] and QUANTO (http://hydra.usc.edu/gxe/). For the case/control comparison we had 80% power to detect an association with obesity with a relative risk of 1.34. For normalized quantitative phenotypes in the cohort of Greek children we had 80% power to detect an effect size (β) of 9.5% of the standard deviation per allele. For the cohort of Greek children of we had a 60% power to detect the observed effect size of β=−0.092. In the case–control study of Swedish obese children and matched controls, we had about 30% power to detect the observed OR of 0.79 (95% CI: 0.64–0.98).
The minor allele frequency of rs2241423 was 21.5% in the obese cohort and 25.8% in the control population. Logistic regression adjusted for gender showed the minor allele of rs2241423 to be associated with a protective effect against obesity (OR=0.79, 95% CI=0.64–0.98, p=0.029) (Table2). Linear regression analysis was unable to detect an association of rs2241423 with BMI within the obese children.
The minor allele frequency in the cohort of Greek children was 24.8%. Linear regression confirmed the association of the minor allele of rs2241423 with a lower BMI (β–0.09191, p=0.028) observed in the Swedish child cohort (Table3). The minor allele of rs2241423 was also associated with smaller hip circumference in the Greek children. A trend towards association of rs2241423 with other measurements of adiposity such as: tricep skinfold thickness, bicep skinfold thickness, subscapular skinfold thickness, suprailliac skinfold thickness and waist circumference was also observed (Additional file 2: Table S1). This was not observed when BMI was included as a covariate in the model. However, a trend towards an association of the minor allele rs2241423 with lower hip circumference was observed after including BMI as a covariate (p=0.095) (Additional file 2: Table S1).
Rs2241423 is located in a haplotype block of about 40kb encompassing part of the last intron of MAP2K5 as well as a downstream region containing 10kb (Additional file 1: Figure S1).This position is in close proximity to a number of potential regulatory sites according to the encyclopedia of DNA elements (ENCODE) (Figure1).
We analyzed the association of rs2241423 to obesity and BMI in two cohorts of children from Sweden and Greece. The minor allele of rs2241423 was associated with a protective effect against obesity in the Swedish cohort, and lower BMI in the Greek cross-sectional cohort, which is in line with published observations on this locus in GWA-studies [1,2]. Analysis of an association of rs2241423 with measurements of body adiposity revealed an association of the minor allele with a smaller hip circumference in Greek children (Additional file 2: Table S1). However, this effect was not detectable when BMI was included as a covariate in the model suggesting that the effect of rs2241423 on body adiposity measurements is secondary to BMI. A trend towards an association of rs2241423 with lower hip circumference was however observed when including BMI as a covariate in the analysis (p=0.095) (Additional file 2: Table S1). We were thus unable to positively report associations with novel phenotypes, perhaps due to the relatively small size of our cohort. Nevertheless, these results confirm the association presented by Speliotes et al. and demonstrates the effects of rs2241423 are detectable already at childhood.
Our results are consistent with previous meta-analyses by the GIANT consortium and Dorajoo et al. [1,2] considering the direction of the effect in cohorts with large age span. The GIANT consortium also reported subsequent meta-analyses focusing on children and revealed an association of rs2241423 with extreme obesity in children in case control studies. In the current study, we find an association to childhood BMI on a population level as well, further strengthening the association of this locus to early-onset overweight and obesity. Studies have suggested BMI to be more strongly influenced by environmental factors during childhood and adolescence, when the child is subjected to the eating habits of the family or environment it grows up in, compared to during adulthood when the child has gained its own independent eating habits [28].
The underlying functional mechanism of the association of rs2241423 variants with obesity, BMI and RLS is, as of yet, undetermined. The close proximity to transcription factor sites in the last exon of MAP2K5 may indicate an rs2241423-linked factor affecting transcription factor-binding and subsequent gene expression (Figure1).
In conclusion, results from the two child cohorts utilized in this study confirm the association of the minor allele of rs2241423 to a protective effect against obesity in children from the Swedish cohort, and with a lower BMI in a cross-sectional cohort of Greek children, which is in line with previous observations in GWAs [1,2]. This demonstrates the effects of rs2241423 to be detectable already at childhood.
The author's declare no conflict of interest.
MRA & JAJ administered the genotyping, conducted the data analysis and authored the draft. Management, collection of information and samples from the cohort of Swedish children was performed by AEE & CM. GM, YM & GPC managed, and collected information and samples from the cohort of Greek Children; JAJ, RF & HBS conceived and planned the study. All authors revised the manuscript and contributed to the discussion. All authors read and approved the final manuscript.
The pre-publication history for this paper can be accessed here:
Figure S1. Linkage disequilibrium (LD) pattern of the proximal region of the obesity associated SNP rs2241423 (marked in red). R-squared scores are used to visualize the LD pattern. Linkage disequilibrium-analysis using confidence intervals according to Gabriel et al. [28] identifies rs2241423 to lie in a haplotype block of about 40 kb encompassing the last intron and exon of MAP2K5 as well as a 10 kb downstream region.
Table S1. Association of rs2241423 to measurements of body adiposity in greek children. * - skewed quantitative variables were normalized by logarithmation.
The study was supported by the Swedish Research Council, Brain Research Foundation, Novo Nordisk, Tore Nilsons foundation and Åhlens foundation. The SNP genotyping was performed by the SNP Technology Platform, Uppsala, Sweden (http://www.genotyping.se) with support from Uppsala University and the Knut and Alice Wallenberg foundation and at the Uppsala Genome Centre. We thank research coordinator Märta Fredriksson and research nurse Micaela Forssén for excellent work with the collection of normal weight adolescents. We thank the Healthy Growth Study Group for their contribution in this study. The Healthy Growth Study Group consists of (1) Harokopio University Research Team/Department of Nutrition and Dietetics: Yannis Manios (Coordinator), George Moschonis (Project manager), Katerina P Skenderi, Evangelia Grammatikaki, Odysseas Androutsos, Sofia Tanagra, Alexandra Koumpitski, Paraskevi-Eirini Siatitsa, Anastasia Vandorou, Aikaterini-Efstathia Kyriakou, Vasiliki Dede, Maria Kantilafti, Aliki-Eleni Farmaki, Aikaterini Siopi, Sofia Micheli, Louiza Damianidi, Panagiota Margiola, Despoina Gakni, Vasiliki Iatridi, Christina Mavrogianni, Kelaidi Michailidou, Aggeliki Giannopoulou, Efstathoula Argyri, Konstantina Maragkopoulou, Maria Spyridonos, Eirini Tsikalaki, Panagiotis Kliasios, Anthi Naoumi, Konstantinos Koutsikas, Katerina Kondaki, Epistimi Aggelou, Zoi Krommyda, Charitini Aga, Manolis Birbilis, Ioanna Kosteria, Amalia Zlatintsi, Elpida Voutsadaki, Eleni-Zouboulia Papadopoulou, Zoi Papazi, Maria Papadogiorgakaki, Fanouria Chlouveraki, Maria Lyberi, Nora Karatsikaki-Vlami, Eva Dionysopoulou and Efstratia Daskalou (2) Aristotle University of Thessaloniki/School of Physical Education and Sports Sciences: Vassilis Mougios, Anatoli Petridou, Konstantinos Papaioannou, Georgios Tsalis, Ananis Karagkiozidis, Konstantinos Bougioukas, Afroditi Sakellaropoulou and Georgia Skouli. (3) University of Athens/ Medical School: George P Chrousos, Maria Drakopoulou and Evangelia Charmandari.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Technically it was a vote on a procedural motion but the effect was the same. The motion failed and Nick Harper will soon be sworn in as the new senator from Everett's 38th District
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Statement from Ned McCormack, Director of Communications for Westchester County regarding HUD's March 25, 2013 letter to County Executive Robert P. Astorino:
The county's position is that it is in full compliance – in fact ahead of schedule – with the settlement's requirements and that HUD's most recent letter of March 25 is just one more example of the federal government trying to bully Westchester to do things that go far beyond the terms of the settlement and dismantle local zoning.
HUD's latest action of unilaterally demanding that the county give up either its constitutionally protected rights or $7 million that it was promised two years ago – money that goes not only to build affordable housing but to communities not involved in the settlement and most in need – shows that HUD has no regard or respect for fairness, due process and the judges of the U.S. Second Circuit who are charged with resolving this dispute.
The county is a year ahead of schedule in meeting the key benchmark of having 300 affordable units with financing in place by the end of 2013. As of today, the county has 305 units.
In all matters, the county has complied with the dispute resolution process outlined in the settlement. On the issue of source of income, the matter is now before the U.S. Second Circuit Court of Appeals, where the county is confident that the U.S. Magistrate's ruling in its favor will be upheld.
On the zoning issue, the county has supplied volumes of data as well as a thorough legal analysis showing Westchester's zoning is not exclusionary. The county would not be ahead of schedule in developing affordable housing in the 31 eligible communities if the zoning in those communities was exclusionary. The impasse is over HUD's refusal to accept the county's well documented conclusions.


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Tatjiana Shone
Listed by Olde Port Properties
Ideal location east of Rt 1. This home sits perfectly on a corner lot in a neighborhood just minutes to the Atlantic Ocean. Single floor living with central air, attached 2 car garage and wood floors throughout. The kitchen has been updated to include granite counters. Master bedroom with bath plus 2 additional bedrooms. Large living room plus a sunny den. Very well maintained throughout. A pleasure to show!
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text: Antiwrinkle Device in U.K. Debut Ultragen is aiming to bring medi-spa treatments to homes. By Becky Wright on August 25, 2008 LONDON — Ultragen is aiming to bring medi-spa treatments to homes. The Tel Aviv-based professional treatment product manufacturer will introduce Stop, a handheld device purported to reduce the appearance of wrinkles using waves of high-frequency electrical energy, in the U.K. starting next month. The device, which heats when in use, is said to stimulate collagen fibers using TriPollar radio frequency technology originally developed for treatments offered in clinics and medi-spas. Treatment regimes comprise 15-minute sessions twice weekly. Stop, which is sold with a preparation gel and post-treatment cream, will retail for 396 pounds, or $734.28 at current exchange, when it bows in Selfridges in September and Harvey Nichols in October. International launch plans have yet to be confirmed. To access this article, click here to subscribe or click here to log in. load comments blog comments powered by Disqus


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Dandelion Root Organic
The Story
Dandelion Root: Taraxacum officinale (F.H.Wigg.)
Why Dandelion Root? A staple of any holistic medicine kit, dandelions have been used for centuries to promote wellness. Dandelion root is rich in active constituents and nutrients (such as potassium) that help promote healthy urination. Dandelion root has traditionally been used in Chinese medicine to promote the immune system, and preliminary research may soon support this usage.
Quality Assured: Our certified organic dandelion root is sustainably sourced from USA. This herb is Certified Organic by Oregon Tilth and grown without the use of genetic engineering, artificial fertilizers, or pesticides. Our experts here at the Apothecary Shoppe personally evaluate every herb through taste, touch, and smell to assure that you are receiving the best botanicals suitable for clinical use.
How to Use
Wellness Support: Dandelion is one of the most valuable wild botanicals. Its cleansing actions and ability to promote movement throughout the body supports organs such as the bladder, gallbladder, kidneys, liver, spleen, pancreas, and more. Dandelion root can also be made into a delicious coffee, which can help naturally reduce caffeine intake.
This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
To make your own dandelion coffee, wash the roots, slice lengthwise in half, and then air-dry for several days. Cut into one-inch sections and roast on a baking sheet at 375 ̊F for two to four hours. Turn them regularly so that they brown evenly. There should be a coffee-like odor coming from the oven by the time they are done. Do not burn. Grind as needed and use in place of coffee beans.
This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Watch ACHS President Dorene Petersen and ACHS CSO Erika Yigzaw identify dandelions in the ACHS Botanical Teaching Garden:


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After Senator Antonio Trillanes earlier said the people are being fooled by President Rodrigo Duterte and his false promises, Mocha Uson reacted and slamed the senator.
"Open your eyes. To the Filipino people, open your eyes, niloloko ka na. Niloloko na tayong lahat," said Trillanes on Thursday. "Sakay na sakay naman yung Pilipino. O di ba hindi niyo nakita na naisahan kayo dun? Ngayon, iniisihan pa kayo. Three to six months, 'I will stop crime.' Sakay na sakay na naman."
Being a vocal supporter of the President, Uson questioned the Senator over his various allegations against the President and answer asked him to provide proof to back up his accusations.
So what can you say about this one? Let us know your thoughts in the comment section below, and don't forget to share this blog post to your family and friends online. And also, visit our website more often for more updates.


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Tag Archives: review
2 Dec 2011
Firelands Raid: In Review
The Hour of Twilight is finally upon us and Patch 4.3 has arrived. I've already dived into the new Dragon Soul raid instance a couple of times and I'm having fun with it, although I'm very keen to get into … Continue reading
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2 Oct 2011
Review: Razer Naga Molten
Last week I took the plunge and decided to order a new mouse. My trusty Logitech mx518 just wasn't up to the challenge and I'd been eyeing up a rival for months – the Razer Naga. I'd been on the … Continue reading
1 Aug 2011
Review: PingCraft LagKiller (Part 1)
Warcraft can be a challenging game at the best of times. Whether it's fighting raid bosses, battling it out in arenas or just trying to cram daily quests into our hectic schedule we all want to be playing at our … Continue reading
26 Jun 2010
Review – Warcraft: MAGE
Expanding on an initial series of manga exploring some of the stories and myths in the Warcraft universe, Blizzard have moved on to produce a series of books focusing on the ten in-game classes. Published by the popular Manga form … Continue reading
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2 Apr 2010
A Moment to Review
It's been an interesting first month blogging about Warcraft. In that time I've covered the patch changes, UI design and addon choices, quirky graphs and diagrams, and roleplay choices and ideas. I've also rambled on about my in-game experiences and … Continue reading
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Daily briefs of the top news stories impacting Christians around the world.
In today's edition:
- Prospects for Peace Increase in Poso, Indonesia
- UK Evangelical Alliance Invites Christians to Join Sharia Debate
- Freed Christian Describes Kidnapping Ordeal in Pakistan
- Kazakhstan: Religious Freedom under Attack
Prospects for Peace Increase in Poso, Indonesia
Following arrests of Islamic terrorists there are grounds for "cautious optimism" for peace in Poso, Indonesia, according to a January report from the International Crisis Group, as Christian and Muslim communities, aided by government initiatives, work towards reconciliation. The Rev. Rinaldy Damanik, a key peace activist during the conflict, said progress has been made but there is still much work to be done in breaking down barriers of hatred and mistrust between the two communities. "It's true that the situation has improved, in the sense that we've had no murders or mysterious shootings in the past year," Damanik told Compass Direct News. "But I'm more concerned about the new community policing system. There is now a police post in every village, with seven to eight police officers. If we only have security when they are present, it's not genuine security. A sense of security must come from within the community."
UK Evangelical Alliance Invites Christians to Join Sharia Debate
ASSIST News Service reports that the UK Evangelical Alliance (EA) is inviting Christians to join the debate on Sharia law by submitting following the Archbishop of Canterbury's recent assertion that the British legal system should accommodate aspects of Sharia law. According to a story written by Jennifer Gold for the web site www.christiantoday.com, the EA is inviting church leaders, theologians and community practitioners to take a fresh look at the place of faith and law in the public square, and the impact that has on community relations and cohesion. "The wider Christian community is also being invited to share its views by submitting comments to the Evangelical Alliance website," she wrote. "The EA is hoping that the exchange of views will help set the agenda for discussions on faith and law in light of the Archbishop's comments."
Freed Christian Describes Kidnapping Ordeal in Pakistan
Compass Direct News reports that a Christian doctor described receiving various death threats while kidnapped recently by Islamic extremists in an area of Pakistan reeling from extremist violence. Militants in parts of the North West Frontier Province have forced Christians and moderate Muslims to don Islamist garb, have bombed CD shops for perceived decadence and, in the case of Dr. Reginald Zahiruddin, have attempted forced conversion to Islam. Islamist militants released Dr. Zahiruddin on January 2, after kidnapping him 25 days prior and demanding he renounce his faith at gunpoint. The kidnappers told Dr. Zahiruddin that the main reason for his abduction was to force him to convert to Islam. "I was bold enough to refuse, and I even told them that God has the authority of taking my life as he has given it to me," the doctor said.
Kazakhstan: Religious Freedom under Attack
With the collapse of the Communist regime and the Soviet state, freedom of religion came to Kazakhstan among other freedoms. Through the work of numerous missionaries the Good News was accepted by large numbers of people, resulting in the birth and growth of many Protestant churches. The churches in Kazakhstan continue to grow and the number of converts from both the ethnic and Russian population continues to increase. However, ASSIST News Service reports, Protestant Christians are still a religious minority in Kazakhstan. Most of the ethnic population historically consider Sunni Islam to be the only true religion for ethnic Kazakhs, while the majority of the Russians living in Kazakhstan relate to the Russian Orthodox Church. The government wants to keep strict control of all religious life in the country, deciding which religions are suitable for Kazakhstan and which are not. There is a growing intolerance of Protestant Christians and some Muslim groups as well as other religious bodies, mainly Jehovah's Witnesses and Hare Krishna.


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Rayne Denise Cook
- Date of birth: Feb 9, 2012
- Date of passing: Jun 26, 2012
|Let the memory of Rayne be with us forever
This memorial website was created in memory of our loved one, Rayne Cook, 0, born on February 9, 2012 and passed away on June 26, 2012. We will remember her forever.
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17-23 January
Make brain-care your priority for 2017 ! Instead of focusing on too many, too expensive and time-consuming new year resolutions, let's focus on a single one, our brain health.
"1. Practice positive, action-oriented thoughts until they become your default mindset and you look forward to creating something mindful and beautiful every new day. Too much stress and anxiety–induced by external events or by your own thoughts–can kill neurons and prevent the creation of new ones.
2. Thrive on Learning. The point of having a brain is to learn and to adapt to challenging new environments. Once new neurons appear in your brain, where they migrate and how long they survive depends on how you use them. "Use It or Lose It" does not mean "do crossword puzzle number 1,234,567." It means, "challenge your brain, and often, with novel activities."
3. Learn more about the "It" in "Use It or Lose It." A basic understanding will serve you well to appreciate your brain's beauty as a living and constantly-developing dense forest with billions of neurons and synapses.
4. OK, remember that the brain is part of the body. Things that exercise your body can also help sharpen your brain: cardiovascular exercise enhances the creation of new neurons (neurogenesis), at any age!
5. Take care of your nutrition. Did you know that the brain only weighs 2% of body mass but consumes over 20% of the oxygen and nutrients we intake? As a general rule, you don't need expensive ultra-sophisticated nutritional supplements, just make sure you don't stuff yourself with the "bad stuff."
6. We are, as far as we know, the only self-directed organisms in this planet. Aim high. Once you graduate from college, keep learning. Once you become too comfortable in one job, find a new one. The brain keeps developing ALWAYS, reflecting what you do with it.
7. Explore, travel. Adapting to new locations forces you to pay more attention to your environment. Make new decisions, use your brain.
8. Don't Outsource Your Brain. Not to media personalities, not to politicians, not to your smart neighbour… Make your own decisions, and your own mistakes. That way, you are training your brain, not your neighbor's.
9. Develop and maintain stimulating friendships. We need social interaction for resilience and mutual support.
10. Laugh. Often. Especially to complex humor, full of twists and surprises, helping keep things in perspective."
Those are 10 ways to do it, proposed by Alvaro Fernandez. Let's take care of our brains, and all the rest will follow 🙂 …as for me, number 1 and 2 will be the priority. Even though I really like to find myself in new situations and environments, and learn new things, I tend too often to let fear and insecurity to prevail, ending up feeling anxious and well.. like crap. It's time to stop and enjoy every bit of what comes !
It happened. Donald Trump started his mandate as president of the United States. Politico (Annie Karni) proposes a short analysis of the five main takeaways of his inaugural speech, that took place on the 20th of January in Washinton. Speech in which he managed to accidentally cite Main, Batman evil enemy
and add a few culture-charged words to the history of presidential inaugural addresses
(credit to Francesco Costa, taken from his newsletter. That I love.)
Good vs Bad Selfishness, The Book of Life. Being labelled as selfish by the ones around us, is the one of the last things we want for ourselves. Is selfishness always that bad though?
"…we collectively fail to distinguish between good and bad versions of selfishness. The good, desirable kind involves the courage to give priority to ourselves and our concerns at particular points; the confidence to be forthright about our needs, not in order to harm or conclusively reject other people, but in order to serve them in a deeper, more sustained and committed way over the long term. Bad selfishness, on the other hand, operates with no greater end in view and with no higher motive in mind. We're not declining to help so as to marshal our resources to offer others a greater gift down the line; we just can't be bothered.
Unfortunately, afflicted by confusion about this distinction, we frequently fail to state our needs as clearly as we should, with disastrous results precisely for those we're meant to serve."
Resonating with the saying "you cannot serve from an empty vessel"*, the minds behind The School of Life invites us to be attentive to our own needs and to take space for ourselves, because even though this might be judged harshly by our loved ones, it is what ultimately lead us to be our better selves and serve them the way they deserve.
*I don't really know from where this expression originates. By quickly googling it I found out it is attributed to writer and life-coach Eleonor Brown. But I don't know anything more about her or the context it was written in and so on and so forth. And I am actually too bored to dig deeper :P. Though, I have heard and read it multiple times in yogic contexts.


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Before you buy any medicine, it is important that you need to learn all about it, especially its side effects and contraindications. The most common side effects experienced by men who took generic tadalafil include stomach pain or discomfort, burping, headache, indigestion, back pain, acid reflux, flushing, muscle aches and a runny or congested nose. These side effects occur because the action of generic tadalafil as a PDE5 inhibitor causes vasodilation (widening) of the blood vessels, but the side effects are short-lived and will go away after a few hours. For instance, muscle aches and back pain may be felt within 12 to 24 hours after generic tadalafil has been taken, and these usually subside after 48 hours have passed by.
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TYLER (TYLER MORNING TELEGRAPH) - Lack of rain, rapid evaporation, a small drainage basin and a slightly leaky dam have again left Lake Tyler with dropping levels.
Lake Tyler as of last week was 2.82 feet below its full capacity, and that already has affected recreational activities.
The leak itself is not a new development. Seepage in the dam has been present since 1978, but the leak was not discovered until a routine inspection in 2005. It did not become a problem until 2009 with the discovery of a "boil," which is water bubbling up with soil.
"As soon as we found it, we installed a V-notch weir to measure it," said Greg Morgan, director of Utilities and Public Works. "Right now, it's leaking at a rate of about 30 gallons per minute. That means, at this rate, Lake Tyler would lose about a foot every 91 years."
Still, it is problem they thought worth fixing.
"Since the water was carrying soil, we were concerned it would widen itself," Morgan said. "It's a problem we wanted to get taken care of before it gets worse."
Working with the Texas Commission on Environmental Quality, the Tyler Water Utilities Department expects to have plans to stop the leak approved by the end of July. They will bid out a contract in August, and begin construction of a "deep soil cutoff wall" in September. The entire process, from approval to completion, is expected to take about six months, with 90 days of construction. The process involves using a machine that works around the clock.
"This project should cost about $4 (million) to $5 million. That money will be coming from the Tyler Water Utilities Capitol Fund," Morgan said. "That doesn't come from tax dollars or anything. We get that money from water utilities bills and revenue bonds."
Still, the leak is not the primary cause for such low water levels in Lake Tyler. The real culprits are the small amounts of rain this year, substantial evaporation caused by sunny, cloudless days and Lake Tyler's small drainage basin. Morgan said it only measures 114 square miles, compared to Lake Palestine's 839 square miles.
Already, these factors are combining to have an effect on water recreation.
"It's not so bad yet, I guess," said Steve Hancock, harbormaster for the Tyler Yacht Club, which has sailboats docked at three piers. "The last few years have been so dry, that's the standard by which everything is judged, but we are worried. Already, about 20 percent of my slips are unusable. If we get to 5 feet down, about 40 percent of my slips will be unusable. Our shallow slip is unusable now, and our deep one will be that way, too, by the time we reach 5 feet. We're getting really concerned."
A slip is the space between two piers where boats are kept.
Yacht club Commodore Bob Horick added, "All you can really do is pray for rain. Then, you can either remove your boat while you wait, or run the risk of hitting ground. It becomes a personal preference. As the saying goes, 'You can't fight Mother Nature.' All you can do is work with her."
That is what happened last time. In 2006, Lake Tyler was 8 feet below capacity. During the course of one three-day weekend, though, a tropical storm brought it to 3 feet above capacity.
"It's all just a matter of getting the right rain in the right place," Morgan said.


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Yuvraj Singh About this sound pronunciation (help·info) (born 12 December 1981) is an Indian cricketer, and the son of former Indian fast bowler and Punjabi movie star Yograj Singh. Yuvraj is a left-hand middle-order batsman and a slow left-arm orthodox bowler. He has been a member of the Indian cricket team in ODIs since 2000 and played his first Test match in 2003. He was the vice-captain of the ODI team from late-2007 to late-2008. At the 2007 World Twenty20, he famously hit six sixes in an over against England's Stuart Broad — a feat performed only three times previously in any form of senior cricket, and previously never in an international match between two Test cricket nations. He was named the Man of the Tournament in the 2011 Cricket World Cup and was one of the top performers at the 2007 World Twenty20, both of which India won.
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Published: Wednesday 29th October 2014 by The News Editor
Williams head of vehicle performance Rob Smedley believes Formula One will again be wasting money if plans to unfreeze the current engine rules are pushed through for next season.
Ahead of this weekend's United States Grand Prix in Austin, battle lines have been drawn of late between Mercedes on one side and Ferrari and Renault on the other as to whether the current regulation should be relaxed.
Following a season of domination in the wake of the introduction at the start of the year of the 1.6-litre V6 turbo-charged power units, Mercedes are naturally keen to maintain the status quo.
At present, the rules dictate no changes are allowed for next season with regard to tweaking the engine, suggesting Mercedes will again have it all their own way.
Just as obvious is the fact Ferrari and Renault, who have comfortably languished behind Mercedes this term, are pushing for change in a bid to challenge.
A situation is due to be debated at next month's meeting of the F1 Commission in which all teams, the FIA, Bernie Ecclestone and race promoters will be present.
A unanimous vote, however, is required for change, and given Mercedes stance it appears unlikely to go ahead unless they can be convinced it is in the best interests of the sport.
Mercedes motorsport boss Toto Wolff has warned of the increased costs, a point refuted by Ferrari team principal Marco Mattiacci.
Smedley, perhaps understandably is siding with Wolff given his cars have been powered by Mercedes this year and are enjoying their best campaign for some time.
Smedley, however, has also put forward some valid arguments as he said: "What you have to consider is what benefit does it bring to the sport.
"Yes, Mercedes have the march on the other manufacturers, but if we open up the engine regulations, Mercedes aren't going to sit still.
"Mercedes are going to do an awful lot of work and put in an awful lot of investment into this current generation of power unit.
"They will come out with something that is much bigger, much better, much stronger, as will Renault and Ferrari.
"In the end we will effectively have the status quo. Nobody will move forward or backward, we will end up where we are, and there will be a great deal of cost involved.
"That cost has to be offset somewhere, and what Formula One doesn't need right at this moment in time is that everybody incurs a huge amount of cost for no benefit to the show."
Smedley believes further cost increases will only dismay the fans who have become frustrated with the soaring amount of money being spent by the teams with little impact on the eye.
"If we open up the regulations we're going to spend an awful lot of money, and to the paying punters, the people that keep this sport alive, what are they going to benefit from it?" questioned Smedley.
"Will we actually benefit from it? If we've x amount on a Ferrari or Renault engine, it's going to stay the same.
"Nobody benefits. It's just a load of cost."
Published: Wednesday 29th October 2014 by The News Editor


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Car sharing company Zipcar on Thursday started service at Chicago's O'Hare International and Midway airports, as it continues to expand beyond its traditional base on city streets and college campuses.
Zipcar's $491 million acquisition by Avis Budget in January has allowed the company to enter the competitive airport car rental market. The entry into O'Hare and Midway brings its airport total to 26.


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Developed By the U.S. Navy Seals... Enough Said
TRX Suspension Trainer
Working out should be an integral part of your life. Maintaining consistency with your workouts is probably the hardest part for many of you (it certainly is for us). Trips, late nights at the office, meeting up with friends, and being tired all make it incredibly easy to start skipping your workouts. With that in mind, the TRX Suspension Trainer doesn't want to hear your excuses. It can be quickly set up almost anywhere, indoors or outdoors, and allow you to get in a quick, scalable workout.
The TRX Suspension System was developed by the U.S. Navy Seals (like another workout tool we've reviewed) and rely's on "leveraged bodyweight exercise." What that means to you is regardless of fitness level the TRX can provide you with a challenging total body workout. Packaged in a convenient mesh bag and weighing less than two pounds means there's no reason for leaving it at home.
After testing the TRX Suspension System, we've been impressed by its ability to facilitate a full body workout. As advertised the TRX effectively hit all muscle groups, a promise often made but rarely fulfilled with fitness gear. The TRX adds some real difficulty to exercises like push ups, reverse rows, core, and hamstring curls by challenging seldom used stabilizer muscles. Utilizing interval style workouts had the added benefit of taxing not only muscles, but our cardio. The TRX will be a definite addition to our luggage on all upcoming trips, and a great supplement to our regular workouts.
Author's Note: The one area I found the TRX to lack was in its explanation of more dynamic exercises. The basic workouts and exercises provided in the DVD and booklet were good and effective, but depending on your fitness level could lose their challenge in short order.
Buy Now: $190 (TRX Pro Pack) | $25 (Door Anchor)


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Thursday, 21 January 2016
WEDDING: My Favourite London Venues!
15 comments
Love this post! I'm getting married in East London this year and found searching for a reception venue pretty tricky in terms of trying to not be too far from a church. I didn't go for any of the above venues, but did check out at the time all the ones you've posted :) xxReplyDelete
This is a gorgeous venue, congratulations on your engagement!ReplyDelete
Kiran | www.alittlekiran.co.uk
I love each of these venues has something so unique & fun about them.. I honestly don't know how bride-to-be's are expected to pick just one!ReplyDelete
I love all of them. If only I lived near to London :(ReplyDelete
Lauren x | www.laurenapowers.blogspot.com
I Loved the old wall shoot! Absolutely great Captures!ReplyDelete
Such beautiful venues. Congratulations on your engagement Katie xReplyDelete
OMG that chandelier! I love it! ♥ReplyDelete
Awwwwh this is gorgeous!!!!ReplyDelete
Hmmm none of these venues are really my cup of tea. At least not for a wedding.ReplyDelete
Wow all these venues would be amazing to get married in! The first one is my fave.. Glad to see some amazing places in london that you could get married in.. Can't wait to see where you've picked to get married xxReplyDelete
London has a lot of elegant and breathtaking places that can make dream weddings come true. These places are some of the best ingredients to make successful and memorable weddings. Thanks for sharing!ReplyDelete
Wish the venues near me were like this. I'm really struggling to find ones fir next spring.ReplyDelete
Beth | Simple but far from basic xx
They helped us put together a great menu, from the consultation to the tasting to the actual event. The Chicago wedding venues had biscuits and gravy, cornbread muffins, fried catfish, jambalaya, enormous pieces of fried chickenReplyDelete
Thanks for sharing this post..Pls visit us:chennai wedding hallReplyDelete
Awesome wedding venue!!! Everything looks so beautiful.. Thanks for sharing your information with us...ReplyDelete
Vincent Raj
Wedding Halls in Mumbai


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Winter Campervan Hire from £35 per day!
Want to explore the UK or Ireland by campervan but think you have to wait for the summer sun? Think again! Without the peak season crowds and prices, there are lots of reasons to travel in winter and campervan and motorhome hire is one of the great ways to see it all!
Tour the beautiful northern highlands of Scotland, visit the quaint countryside in southern England or explore Ireland's mesmerizing Wild Atlantic Way at its wildest. With so much to see, only you can set the trail to your campervan holiday this winter. From November – December, pick up a camper from our depots across the UK & Ireland with prices from as little as £35 per day.
The Roadie – Great value transport & accommodation in one.
With prices from just £35 per day, the "Roadie" is a practical, functional and economical way to get around on your winter campervan holiday. Like car hire with benefits, the Roadie is compact and economical to drive with the added benefit of camper facilities including everything you need to cook, sleep and relax on the road, meaning this really is your accommodation and car hire in one. On board facilities include:
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Don't Forget to check your campsite!
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Book Now for winter!
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Yesterday I asked my readers on Facebook what foods come to mind when they think "liver cleanse". Here are some of the responses: fruit, lemon water, milk thistle, dandelion salad, kombucha, beet juice, cabbage, olive oil, citrus, nettles, tumeric.
These are all wonderfully cleaning foods, but we are missing a few key players. This list is missing meat, eggs, and dairy. Are you shocked? Stay with me and I can explain why I am adding such "heavy", "clogging" foods to a detox food list.
My Story
A few years ago I decided I needed to seriously detox my body. I was newbie to the whole foods movement and after reading that, the average newborn baby has 287 known toxins in his or her umbilical cord blood (Source), I became concerned. I couldn't stop thinking about all the toxins I was carrying around with me all the time. My poor liver needed my help!
So I got some green powder from the whole food store that promised to detox, cure acne and eczema, relieve my digestive bloat, and balance my mood swings, all in less than three days. I was sold! I came home and started drinking it with carrot, beet, apple, celery juice,and lots of water. I felt very empowered. I was in control. I was beating these toxins out of my body!
The first day I felt great! I was hungry but the fresh squeezed juice had plenty of sugar so I was bouncing off the walls. The next day I began feeling sick and sluggish and started getting chills, and eventually I developed a fever and really intense diarrhea and dizziness. I just wanted to sleep, but I was too hungry to do so! The rash on my face flared up even more. The end of the day found me sheepishly eating some rice and hard boiled eggs thinking to myself "I failed my liver". 🙁
Four Years Later
After reading, researching, and taking classes on detoxification, here is a little secret most detoxification protocols don't tell you. The liver can't detox without protein! Let me explain. The liver has two detoxification pathways.
Phase I
The liver deactivates toxins by making them water-soluble through the biochemical processes of oxidation (where electrons are lost) and reduction (where electrons are gained).Cytochrome P450 enzymes are responsible for most phase I reactions. Once the toxins are water-soluble, we can excrete them from our system. Bright colored vegetables, dark leafy greens, seeds, and nuts all support this phase.
If this phase were able to get rid of all of our toxins, green juice fasting would be perfect! But here's the catch – not all toxins are created equal. While this enzymatic process renders a lot of toxins harmless, it can also make other toxins even more dangerous through a process called bioactivation.
The initial view that the cytochrome P450 enzyme system functions simply in the deactivation of xenobiotics is anachronistic on the face of mounting evidence that this system can also transform many innocuous chemicals to toxic products. However, not all xenobiotic-metabolising cytochrome P450 subfamilies show the same propensity in the bioactivation of chemicals. For example, the CYP2C, 2B and 2D subfamilies play virtually no role in the bioactivation of toxic and carcinogenic chemicals, whereas the CYP1A, 1B and 2E subfamilies are responsible for the bioactivation of the majority of xenobiotics. Electronic and molecular structural features of organic chemicals appear to predispose them to either bioactivation by one cytochrome P450 enzyme or deactivation by another. Consequently, the fate of a chemical in the body is largely dependent on the cytochrome P450 profile at the time of exposure. Source
Enter phase II liver detoxification.
Phase II
This second stage joins toxins, via a process called conjugation, with sulfur and amino acids in order to flush them out of your system. Guess what foods support this second stage. Foods high in amino acids and sulfur, like eggs, meat, fish, and even dairy!
The most important amino acids for Phase II detoxification are cysteine and methionine.
These two amino acids are the main dietary sources of sulfur and are found in meat, fish, poultry, eggs and dairy products. Vegetarian sources of cysteine and methionine include nuts, seeds and beans. The usual adult RDA of cysteine and methionine is 700 to 1000 mg per day, but is never fixed because it fluctuates with the liver's burden of toxic compounds. The body's stores of these amino acids are depleted in the process of detoxification, so the greater the toxic stress, the more the body demands. Source
The higher the toxic load, the more amino acids are required to conjugate toxins and remove them from the body. So next time you decide to embark on a liver cleanse, combine your green juice, dandelion, bitters, and green veggies with runny egg yolks, pastured meat, and fermented raw dairy, if you can. Our bodies need both in order to function well.
So what happens when you don't eat the necessary protein, but continue to drink juice and other foods that support for Phase I but avoid protein and fat? You will loose some weight. You might be thinking "That's wonderful!" It is and it isn't. A lot of very toxic compounds are stored in your fat cells. When you start loosing fat and these toxins are dislodged, free to roam through your blood stream, your liver has to do double duty to flush them out. If there's too many of them at once, the liver gets overwhelmed, and if you're not eating enough protein, you won't have enough amino acids or sulfur to deactivate them. This can cause head aches, fever, chills, and even activation of auto immune disease.
So please, for the love of your liver, don't embark on detox protocol without having the correct nutritional support.
Keep Things Moving
Lastly, don't forget that, even though those toxins are neatly packaged and ready to be flushed out of your system, they will be reabsorbed back into your blood stream if you aren't having regular bowel movements. This last phase is just as important as phase I and II!. Choosing to eat lacto-fermented foods like traditionally made sauerkraut, pickles, kimchi, or raw yogurt can be very helpful. These wonderful foods will populate your colon with healthy bacteria and keep things moving. I advise combining the powers of these foods with a probiotic supplement, especially during times of stress and sickness. At the moment I am taking probiotics to support my detox organs and help heal my recently discovered dairy intolerance.
The best defense is a good offense.
Periodic cleansing is good and necessary, but a more proactive and ultimately healthier strategy is to start cutting toxic foods and products out of your life altogether, where possible. Your liver is a magical organ and a strong ally, for which you should be very grateful – and protective. Swinging back and forth between high toxic load and extreme detoxification stresses your liver and can cause illness and severe health issues. Body care products, cleaning supplies, pesticides, hormones, antibiotics, industrial chemicals, building materials, and more, all contribute to toxic load. Be aware of your exposure to these things, and take steps to minimize their influence. Choose to eat only clean organic produce and use mild natural products. Strengthen your body's immune system by doing yoga, breathing exercises, dry-brushing and meditation for extra resilience to toxins.
Lastly, it's about more than what you consume. My grandfather lived to the ripe age of 97, and I never saw him sipping on a big glass of green juice. His favorite meal was a big breakfast of scrambled eggs, polenta, and homemade fermented feta cheese, with a large cup of rose hip and chamomile tea. He was a shepherd after he retired from his teaching job. He spent his days reading books and playing his hand-carved whistle while hiking through the fields around our little village in search of fresh grass for his sheep, who followed him faithfully. He worked hard long days, and he also knew the meaning of true rest and relaxation. While it is essential to have the correct nutritional support for a detox protocol, remember that your lifestyle plays a critical role also. Be physically and mentally active, and eat a simple diet of balanced food groups. It's the way our ancestors lived, and the way they remained healthy and free of dementia or Alzheimer's into old age.


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You might have read the title of my post and wondered...stigma? What's that?
It's defined as: "a mark of disgrace associated with a particular circumstance, quality, or person."
In other words, it's shaming something you might not know a lot about. Sort of like a stereotype. And for those of us with mental illness, I'm sure we can all testify to the fact that we face stigma...A LOT. And I firmly believe that if the world knew more about mental health, we'd be a lot more understanding of one another.
So I thought I'd give you some insight into some stigma I have personally faced, and some good explanations as to why they aren't true.
1) You just have to wake up in the morning and choose to be happy.
First off, as somebody with depression, it's hard to even wake up some days. Many times throughout the school year, I would just lay in bed and cry because the thought of getting out of bed seemed like too great of a task and I just couldn't handle even the simplest things the day had placed before me. Secondly, happiness is not always a choice. It's a feeling. Perhaps positivity is more of a choice, but even then, there are many days when it is the harder one, and you just can't fight. Therefore, it's not as simple as you put it. Chemical imbalances are real and can be extremely frustrating. People with depression just see life differently. With a lot of gray filters. And you can see the difference quite clearly in the image below:
2) You're selfish/self-centered.
I think this was one of the worst things to hear. If we take a step back, aren't we all selfish? Are we not all the same selfish sinners? We think we can save ourselves, and that's where the problem is. Our salvation comes through Christ. Even in the ugly world of depression, it's not something you can fight alone. Jesus is the answer. He was the opposite of selfish...for me and the rest of the nasty sinful world. But I promise you that I have a big heart. Really, I do. I, myself, do not hold that terrible of a selfish nature in the personality sense. But my demons do. The ones that take hold of my life and make my head spin. They're the self-centered ones. But me? I'm just trying my best to take care of me first, and even then, I'm helping others along the way. Hence, Depressed But Blessed.
3) You take too much pride in your depression/Depressed But Blessed.
Pride. Does that even make a lot of sense? I am not proud of the darkness that sits inside my head. I am not proud of my scars, rather ashamed. I am not proud of only myself for coming this far. You know why? Because this is not my battle alone. Christ has conquered death, the devil, and the world for me and for you! And that's something to take pride in. The fact that my God sent His Son and humbly died upon the cross. I can rejoice and be proud of the fact that I have eternal life waiting for me at the end of all my struggles. Only because Jesus tackled it all for me.
As far as pride in my blog goes, you need to understand why I write. It's purpose is to help all of you. At first, yes, I did start it to help me get some of my feelings out. But now, it's my way of showing you that you are not alone, and that you have a God who is always by your side. I don't want any of you to feel like you have to run the race alone. Because I know that not all of you have faith in Christ like I do. And with such faith, I can only pray that maybe I can be a blessing unto you. I truly only want to help put an end to stigma against mental health, and the only way that comes is by spreading the word about what it really is.
4) It can't be that bad.
I'm sure we can all think of those Tumblr pictures of teenagers in settings with solemn looks on their faces, right? It probably has a sad (and maybe cheesy) quote to match. Here's a newsflash: depression is scarier than having some tears run down your cheeks as you sit in an empty parking lot. It's terrifying. It means having days where you can't even recognize yourself. You don't feel human; you go through the motions of living but yet you aren't truly living. You're just trying to survive. The demons in your head bully you and the constant internal battle nags away at you. Mental illness takes a huge toll on not only your mental/emotional health, but also your physical health. Sleeping, eating, learning, and many other things become challenges. So, I mean it when I say, I wouldn't wish depression or anxiety on my worst enemy.
I am a firm believer that stigma can be reduced a ton if we just took time to do some simple research, or listen to others. That's why I am a proud supporter of Project Semicolon and Mental Health America. We just need to educate each other on these things and soon enough, we can all feel a little better about ourselves and others.
Take the "stigmafree pledge" here: https://www.nami.org/stigmafree
Let's make the world a little better of a place to be;
and let's go and be #STIGMAfree,
Marissa Mayer


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Business Briefs
Green Mtn Traffic Control staffers receive accreditation
BELLOWS FALLS >> In November, two of Green Mountain Traffic Control's staff members completed their ATSSA Traffic Control Technician trainings: Wes Wright, operations chief, and Morgan Wright, senior supervisor. For more information, contact Deb Wright at 802-463-4380.
Local Tae Kwon Do instructor reaches 4th degree
WILMINGTON >> Vermont Valley Tae Kwon Do recently announced the promotion to 4th Degree Master of Karina Morehead of Wilmington.
Morehead has been training and teaching Tae Kwon Do since 1989, and showed her potential at the age of 11, winning both Gold and Silver medals at the 1990 AAU Vermont State Championships. Her continuing training includes Combat Hapkido, Kum Do (Korean Sword), The Cane Masters System, and she is experienced in Koho Shiatsu massage. During the week Master Morehead can be found at Hairaphernalia in West Dover.
Vermont Valley Tae Kwon Do's founder, Master Jeanette Toro Linnehan, awarded the Master's rank in a testing on Jan. 29 at the studio. Also serving on the board were Master Mike Linnehan, and Master George Adair. With the promotion of Master Morehead, Vermont Valley becomes one of the few Martial Arts studios with four Master Instructors on staff.
Marlboro College hosts board program
MARLBORO >> The Center for New Leadership at Marlboro College has announced the 2016 Get On Board Fellows Program, designed to give Windham County residents, age 22 to 44 the opportunity to build leadership skills and their personal and professional networks while serving the community.
Fellows attend all Board Leadership Institute workshops and personal leadership development sessions for $100 to 200 sliding scale which is less than half the full cost. Through these events, Fellows will build relationships with each other, and with members of local nonprofit boards. Fellows will also receive extra recognition during the Board Matching Event, which will help them make connections with nonprofit boards that match their interests and passions.
"In a place like Vermont where the population tends to skew to the older end of things and especially with regard to board service, it can be difficult for excited and well-qualified young folks to break in to an organization's board. It serves the organizations, youth of the community, and the boards themselves to have new perspectives and people on the board. I would not have served on a board without this program. Both myself and my organization are better for it," said a 2013 GOB participant.
Learn more online at www.marlboro.edu/cnl.
Hospice welcomes Rueter as coordinator of Taking Steps Brattleboro
BRATTLEBORO >> Brattleboro Area Hospice is pleased to announce the recent partnership with Joanna Rueter, LICSW, to coordinate Taking Steps Brattleboro, a new initiative focused to increase the numbers of people throughout the region who have completed the advance care planning process.
Rueter, the owner and founder of Sustainable Aging, LLP, since 2011 leads workshops, community presentations, and facilitates advance care planning. She has created and maintains the website and blog, www.SustainableAging.com. In 2014 Rueter completed the facilitator and instructor certification in advance care planning, at Respecting Choices an internationally acclaimed ACP program in La Crosse, Wisc.
Taking Steps Brattleboro is a collaborative, community-based initiative intended to achieve a significant increase in the numbers of people in the Brattleboro area who have completed the advance care planning process. This is accomplished by collaborating to educate the community about advance care planning and by offering trained volunteer facilitators to work with individuals to negotiate the process and to register the completed forms.
To schedule a presentation, or to talk about your individual questions about advance care planning call Joanna Rueter at 802-257-0775, ext. 101, or by e-mail at email@example.com.
Taking Steps Brattleboro is a project of Brattleboro Area Hospice, an independent, community-based, non-profit organization that provides grass-roots, volunteer-staffed programs to supplement and provide alternatives to the professional services utilized by dying and grieving community members.
Brattleboro Area Hospice, including Taking Steps Brattleboro is locally funded and provides all services free of charge. Its office is located at 191 Canal St. Services and programs are also offered in the Bellows Falls community.
For more information about Brattleboro Area Hospice or Taking Steps Brattleboro, visit www.brattleborohospice.org.
River Valley CU promotes Collins
BRATTLEBORO >> River Valley Credit Union announced the recent promotion of Crystal Collins, who began at River Valley Credit Union in September 2012 and worked as a teller in the Brattleboro, Putney and Townshend offices. Collins transferred from the Townshend branch to the Operations Center in August 2015 beginning her position as a receptionist. Most recently, in November 2015 Collins was promoted to Operations Analyst II. River Valley members can note that many of the familiar faces they see in our lobbies are promoted from within.
Green Economy Industry Cluster launches action teams
BRATTLEBORO >> Southeastern Vermont Economic Development Strategies and Brattleboro Development Credit Corporation recently conducted the first meeting of interested stakeholders in the Green Economy Industry Cluster Initiative with the Tri State Region Leadership Team. Three "action teams" are now charged with defining niche market business opportunities that can be acted upon to benefit the region.
The Cluster Initiative is being undertaken as a high priority project from the Windham Region S.M.A.R.T. Comprehensive Economic Development Strategy completed in 2014. A CEDS is a federally approved process and plan for growing a regional economy. The Green Building and Services Sector, Technology Driven Precision Manufacturing and Healthcare were identified as the highest priority sectors for replacing the high skill high wage jobs being lost by the closure of Entergy's Vermont Nuclear Power Plant. This first Cluster Initiative, funded by BDCC and SeVEDS, The Windham County Economic Development Program and the US. Department of Commerce Economic Development Authority, is due to be completed by November 2016.
The action teams resulting from Wednesday's meeting, consist of 68 local business and knowledge leaders across the four-county area of Franklin, Cheshire, Windham, and Bennington, who will develop market opportunities identified to-date by lead consultant ViTAL Economy and local partners, BuildingGreen and the Resilient Design Institute, into veritable business cases that will support new job growth.
Participants in Wednesday's meeting were presented with economic and market research that highlighted the region's specific challenges, as well as growth markets that the region is well positioned to tap into. For example, population in all four counties studied was lower in 2014 than it was in 2010, compounding the challenge for existing businesses to find qualified workforce and leading some companies to go out of business.
Alex Wilson, chair of the cluster explained the region can become "a place where specialized career training takes place to build a skilled workforce in specialized areas. Ultimately increasing the size of the workforce." Wilson explained that "if we succeed with this project, the region will not only weather the loss of jobs from the closure of Vermont Yankee, but actually grow the workforce in jobs supporting the emerging green economy."
The 2,200 jobs that currently exist in the green goods and services sector within the region—totaling $238 million in GDP — represent unique assets that can be leveraged to attract more people and companies to the area, according to ViTAL Economy. The national market for green goods and services is estimated to double in the next three years, and given the local concentration of these jobs, as well as the area's strong culture of green ethics, there is tremendous opportunity for the region to match that growth.
"This is a national and global opportunity to take the real strengths of the region and transform this place," said Frank Knott of ViTAL Economy. "There is very significant breadth and depth of knowledge about sustainability and resilience here."
Members of the community action teams will be exploring business cases for the following opportunity areas in pursuing a green economy: creating a Knowledge Center to attract talent, investment, businesses and visitors; developing innovative finance, insurance, and appraisal tools that can be applied nationally; and researching, prototyping, or developing new services for the green construction or resilient design markets. Progress will be reported at the next stakeholder event scheduled for the first week of May.
For more information on the Cluster Initiative, visit www.brattleborodevelopment.com/economic-development/projects/greeneconomy.
If you'd like to leave a comment (or a tip or a question) about this story with the editors, please email us. We also welcome letters to the editor for publication; you can do that by filling out our letters form and submitting it to the newsroom.


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With digital marketing completely dominating 2016, it is obvious that 2017 will follow with even bigger digital trends in the business world.
With the increasing usage of smartphones, spreading your business message through mobile "screens" is the most effective way of advertising today.
As well as the most cost effective!
If you are looking to expand your business marketing reach in the coming year, here are some of the most popular trends of digital marketing that we will be hearing about in 2017. Continue reading


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Product 5/5
A world first! Outdoor gym equipment that generates human powered electricity. Upgrade to a piece of Cardio Charge equipment and charge your mobile phone or tablet whilst exercising. WOW!
The Energy Spinning Bike is a classic machine for any gym. This cardiovascular piece of equipment works the lower body as well as heart and lungs. Install several together to create an outdoor spinning class. All the mechanisms and built in resistance are cleverly concealed within the housing. This makes the Energy Spinning Bike extremely safe as well as protected from the elements. Leaving it ready and smooth to be used by anyone, whatever the weather.
1. 100% Made in Britain
2. Certified to EN16630 (legacy standards, BSI PAS888 - safety compliant for ALL ages, users and non-users) & DIN79000 (safety compliant for users, aged 14+). All TGO outdoor gym equipment is free from exposed end stops, entrapments, sharp edges and crush points.
3. Unique TGO Green Energy technology
4. Low voltage
5. 2x USB Ports
6. Interactive power display on console
7. No need for mains / any external power supply
8. Weather proof
9. Mobile phone charging console with USB charger and watt meter
10. Great instructional signage - workout QR code videos, start and finish diagrams
11. Free at the point of use
12. Resistance - based equipment - no electricity required
13. Low maintenance
14. Designs include key elements of IFI (Inclusive Fitness Initiative) guidelines
15. TGO plant a tree in the NHS Forest for every piece of equipment sold
Guarantees: 25 years steel work; 2 years bearings; 5 years paint
Why choose TGO? - see our Greener, Safer, Stronger standards
Spinning Bike:
(Approx) Length: 1035mm
(Approx) Width: 482mm
(Approx) Height: 1330mm
(Approx) Weight: 80,5kg
Generates electricity. Improves muscle stamina and endurance. Improves heart and lung function over a period of time. Tones the legs and bum.
View all packages
View all products
The University of Warwick's vision is to be the most active campus in the UK by 2020. Working closely with the University the aim was to develop an inspiring and aspirational environment where students, staff, coaches and support staff are offered premium facilities to enhance their overall experience. The facilities will offer a campus environment that supports sport, health and wellness for students, staff, partners and visitors.
Did you see it? TGO proudly featured in DIY SOS: Veteran Street which aired 8th November 2017 at 8pm. Missed it? Don't worry you can find out the whole story here...
The Great Outdoor Gym Company (TGO) have joined Nick Knowles and the DIY SOS team again to help get people active and improve lives. The programme will be broadcast on BBC1 on Wednesday 8th November 2017 at 8pm
After becoming a finalist for this year's Swale Business Awards TGO met with judges to enable them the opportunity to show off the business and explain to the judges why TGO deserve to win Swale Business of the Year 2017.
The awards evening took place on Friday 22nd September which TGO attended leaving as WINNERS!
TGO are proud to manufacture 100% in the UK but export worldwide. Exports include Singapore, Australia, UAE, Hong Kong, Mauritius, Northern Ireland, Frace and many more...
If your gym is in a harsh enviroment (near a coastline, tidal river, in a humid or saline region) a 'galvanised upgrade' will be necessary for the warranty.
The TGO gym has been created using reproduced aluminum from old deodorant and antiperspirant cans in partnership with Right Guard and TerraCycle. The gym which has been donated to Queen Elizabeth Olympic park, has now offically opened to the public.
We've hit double digits at TGO, a very special birthday for us.
The Canterbury Times met up with The Great Outdoor Gym Company, to test out our range of outdoor fitness equipment and to talk about TGO's mission to drive up activity and improve wellbeing in sustainable ways.
Enter your email address below to receive information about our products, brochures, latest news, new gyms installed & special offers.


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NICO White Stripes
Long Sleeves T-shirt
Classic with a twist. A long sleeve crew neck tee - shirt is an essential season - round layer. Tie & dye, stripes or colorblocks, we have honed our Nico tee - shirt to have the perfect straight fit smart details and premium 100% cotton fabric provides comfort and long - lasting quality.
- Comfort Fit
- Crew Neck
- Long Sleeves
- Thumb Holes
- Mini Rib Fabric
100% Cotton
- Keep away from fire
- Machine wash inside out with similar colors
- Do not bleach
- Tumble dry
- Iron inside out
- Dry cleanable
- Natural dry advised
40.00 €


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ATLANTA, Ga -- Police say a man who was found lying behind a tractor trailer Sunday morning in downtown Atlanta had been shot in the head.
The man was discovered by a passing motorist in the I-75 southbound emergency lane near Capitol Avenue around 7:10 a.m., according to police. The 9-1-1 caller was en route to the Atlanta airport and had left the scene by the time police arrived.
The victim was bleeding from the head and was unresponsive when he was taken to Grady Memorial Hospital. Doctors performed a CAT scan on the man, which revealed he had been shot in the head.
Police recovered several shell casings from the scene.


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Fair Day 2017 – How Do You Do It? LaunchMarch 28, 2017
Launch of the 'How Do You Do It?' campaign at Fair Day 2017.Read
Launch of the 'How Do You Do It?' campaign at Fair Day 2017.Read
Just like glitter, the memories of Mardi Gras don't fade quickly. This year we danced and marched in pink, blue…Read
As the International AIDS Conference in Durban brings together the globe's foremost authorities on combatting HIV/AIDS, award-winning American program PBS…Read
Sydney shines as ACON dances their way to celebrate Mardi Gras 2016.Read
The giant condom returns to Sydney's Hyde Park Obelisk and Bondi Beach goes pink as part of ACON's Stay Safe campaign.Read
Ending HIV – It's possible, but only if we work together. By testing more, treating early and continuing to stay…Read
HIV treatments have changed – if an HIV positive person is on treatment and has an undetectable viral load, the…Read
Sydney-siders stopped in their tracks when a #GiantCondom appeared in Hyde Park on November 7, 2014. The condom raised awareness…Read
To end the HIV epidemic by 2020, we need to know our status by testing much more regularly than we…Read
One of the main ways ACON is committing to ending HIV by 2020 is through sustained advocacy efforts on behalf of our community as well as feeding information about the effectiveness of the ENDING HIV initiative back to the community… Read more.


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BITSAT Eligibility Criteria 2017- check age limit and educational requirement here..!!
BITSAT Eligibility Criteria 2017 is a set of the conditions that must be satisfied by the candidates in order to be eligible for the exam. It is necessary for the candidates to be eligible for the admission process otherwise they will not be allowed to appear in the exam. In this article, we have provided the BITSAT 2017 Eligibility Criteria details that will help candidates in checking their eligibility for the exam.
|Important Links
|BITSAT 2017 Exam Pattern
|BITSAT 2017 Application Form
Candidates can simply check the BITSAT Eligibility Criteria 2017 provided and apply accordingly:
All the above given Eligibility Criteria BITSAT 2017 must be satisfied by the candidates in order to be eligible for the exam. If ineligible candidates submit their application for the exam, then it will not be accepted. Moreover, the inappropriate forms will be canceled in the screening process without any information, and the application fee will not be refunded as well.
Keep Checking CareerLive360 for Latest updates on BITSAT Eligibility Criteria 2017..!!


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Jewelry (Korean: 쥬얼리) is a South Korean girl group which was formed in 2001. Its most successful album was Kitchi Island (2008). As of 2013, they are the longest running Korean girl group (with more than 2 members) ever, surpassing super-group Baby V.O.X.
On March 3, 2014, it was revealed that Eunjung's contract had expired and she would be leaving the group. Yewon was casted on a weekend drama, Hotel King. In the drama, she played the role of an enthusiastic front desk officer. On April 17, 2014, Yewon hosted a talk show Mnet Mcountdown Begins with Kwill. Semi was cast in a new sitcom, Boarding House no 24 as Park Semi who is the niece of the boarding house.
On November 19, 2014, Baby J revealed that she will be leaving Jewelry as her contract expired last August. It was also revealed that Semi would not be renewing her contract after it expired that month.
On January 7, 2015, the group was officially confirmed as disbanded.


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The persons interested in the service can sign up on www.microsim.ro website.
"The introduction of micro-SIM card in Romania comes to meet smartpone and table PC users' needs. Micro-SIM will address a wide variety of devices in the future", said Lee Wilkins, senior manager of the carrier.
Vodafone Micro-SIM card is provisioned for voice and data services and are available for prepaid and postpaid users. The new mirco-SIM measure 15mm x 25mm as opposed to the regular 15mm x 25mm cards, and the width remained at 0.76mm.
Vodafone customers will now have the possibility of choosing between the new micro-SIM and a regular SIM when subscribing to a data plan, by selecting it on Vodafone.ro. Vodafone's existent customers can switch their regular SIM with a micro-SIM following the standard procedures.
The new micro-SIM will be available online and at Vodafone stores for all users, as of mid July. The pricing of micro-SIM plans will be standard, both for voice and data.
Inregistreaza-te pe Wall-Street sau conecteaza-te prin Facebook pentru a primi periodic articole similare.
In lipsa unui acord scris din partea InternetCorp, puteti prelua maxim 500 de caractere din acest articol daca precizati sursa si daca inserati vizibil linkul articolului Vodafone launches smartphone, tablet PC SIM.


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Plot: When Eddie lands his first teaching gig at an inner city middle school, he quickly finds that his highly pubescent pupils are receiving no form of sexual education. Eddie isn't exactly equipped to teach them – he's not exactly experienced romantically. And he's falling in love with the older sister of one of his students. But Eddie goes off lesson plan anyway, delving into the world of menstrual cycles and sexually transmitted infections, and in doing so, incurs the wrath of the local reverend.
Genre: Comedy | Romance
IMDB Rating: 5.6/10 from 3,806 users
Directed by: Isaac Feder
Starring: Haley Joel Osment, Laura Harring, Abby Elliott
Release Name: Sex.Ed.2014.BRRip.XviD.MP3-RBG
Size: 1.06 GB
Video: AVi | 720×300 | 1 429 Kbps
Audio: English | MP3 | 192 kbps
Runtime: 1h 33mn
Subtitles: N/A
Samples: Video @ #1 , #2 , #3
Links: iMDB | Trailer | NFO | Torrent Search
Download: NiTROFLARE – UPLOADED – RAPiDGATOR – UploadRocket
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