text:
Capecitabine as Radiosensitising Agent in Neoadjuvant Treatment of Locally Advanced Resectable Rectal Cancer
This study has been completed.
Institute of Oncology Ljubljana
ClinicalTrials.gov Identifier:
First Posted: June 29, 2010
Last Update Posted: June 29, 2010
Information provided by:
Institute of Oncology Ljubljana
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
A Phase II study aimed to evaluate the efficacy and toxicity of preoperative chemoradiotherapy with capecitabine in locally advanced resectable rectal cancer.
|Resectable Rectal Cancer Clinical Stage II and III
|Drug: Capecitabine
|Phase 2
|Study Type:
|Study Design:
|Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|Capecitabine as Radiosensitising Agent in Neoadjuvant Treatment of Locally Advanced Resectable Rectal Cancer
Resource links provided by NLM:
Drug Information available for: CapecitabineU.S. FDA Resources
Further study details as provided by Institute of Oncology Ljubljana:
Primary Outcome Measures:
- complete pathological remission rate [ Time Frame: 9 weeks ]after pathological examination of resected specimen
Secondary Outcome Measures:
- the rate of sphincter preservation in low-sited tumours [ Time Frame: 9 weeks ]after the operation
- toxicity of combined modality treatment (Number of Participants with Adverse Events) [ Time Frame: 5 weeks ]During preoperative treatment, patients will be evaluated weekly for acute toxicity and compliance with the protocol. Clinical examination and complete blood count will be performed and body weight was measured. Toxic side effects will be assessed according to National Cancer Institute Common Toxicity Criteria (NCI-CTC) (version 2.0). Patients will be followed every three month for the first two years after the last cycle of adjuvant chemotherapy and thereafter every six month up to 5th year.
- overall downstaging rate [ Time Frame: 9 weeks ]after the pathological examination of resected specimen
- overall survival [ Time Frame: 5 years ]Overall survival is defined as the time from inclusion to the date of death from any cause or to the date of last follow-up.
- local control [ Time Frame: 5 years ]Local control is defined as the time from inclusion to the date of local recurrence
- relapse-free survival [ Time Frame: 5 years ]Relapse-free survival iss defined as the time from inclusion to the first occurrence of disease relapse (local or distant), death or date of last follow-up.
- long-term rectal and urogenital morbidity [ Time Frame: 2 years after the surgery ]
|Study Start Date:
|June 2004
|Study Completion Date:
|April 2010
|Primary Completion Date:
|March 2006 (Final data collection date for primary outcome measure)
Intervention Details:Detailed Description:
Drug: Capecitabine
Chemotherapy with capecitabine of 1650 mg/m2 daily dose will be administered orally, divided into two equal doses given 12 hours apart, during radiotherapy(45 Gy 1,8 Gy/fr), including weekends
Other Name: Xeloda
Preoperative chemoradiation has become a standard part of treatment protocols in stage II and III rectal cancer. Compared to postoperative chemoradiotherapy, the advantage of preoperative application of chemotherapeutics and irradiation includes improved compliance, reduced toxicity and downstaging of the tumour in a substantial number of patients. The latter may enhance the rate of curative surgery, permit sphincter preservation in patients with low-sited tumours and have a positive impact on the quality of life of these patients. Orally administered capecitabine (Xeloda®, Hoffmann - La Roche Ltd, Basel, Switzerland) mimics the pharmacokinetics of continuous 5-FU infusion and makes chemoradiotherapy more patient-friendly. The mechanism of capecitabine activation, preferably in tumour cells, may further enhance its efficacy and tolerability, offering the potential for an enhanced therapeutic ratio.The aim of the present phase II study was to evaluate the efficacy and toxicity of preoperative chemoradiotherapy with capecitabine in patients with locally advanced rectal cancer. The primary endpoint of the study is a pathologically determined complete remission rate (pCR) of the disease locally and regionally. Secondly, the rate of sphincter preservation in low-sited tumours, overall downstaging rate,toxicity and survival parameters will be analysed.
Information from the National Library of Medicine
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years to 80 Years (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- histologically verified adenocarcinoma of the rectum,
- resectable clinical stage II or III (IUCC TNM classification 2002);
- no prior radiotherapy and/or chemotherapy;
- World Health Organisation (WHO) performance status < 2;
- age at diagnosis of 18 or older;
- and adequate bone marrow, liver, renal and cardiac function (no history of ischemic heart disease).
Exclusion Criteria:
- A history of prior malignancy other than non-melanoma skin cancer or in situ carcinoma of the cervix
Contacts and Locations
Information from the National Library of Medicine
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01152710
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01152710
|Institute of Oncology
|Ljubljana, Slovenia, 1000
Sponsors and Collaborators
Institute of Oncology Ljubljana
More Information
Keywords provided by Institute of Oncology Ljubljana:
Additional relevant MeSH terms:
Velenik V, Anderluh F, Oblak I, Strojan P, Zakotnik B. Capecitabine as a radiosensitizing agent in neoadjuvant treatment of locally advanced resectable rectal cancer: prospective phase II trial. Croat Med J. 2006 Oct;47(5):693-700.
Sauer R, Becker H, Hohenberger W, Rödel C, Wittekind C, Fietkau R, Martus P, Tschmelitsch J, Hager E, Hess CF, Karstens JH, Liersch T, Schmidberger H, Raab R; German Rectal Cancer Study Group. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med. 2004 Oct 21;351(17):1731-40.
Schüller J, Cassidy J, Dumont E, Roos B, Durston S, Banken L, Utoh M, Mori K, Weidekamm E, Reigner B. Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients. Cancer Chemother Pharmacol. 2000;45(4):291-7.
Kim JS, Kim JS, Cho MJ, Song KS, Yoon WH. Preoperative chemoradiation using oral capecitabine in locally advanced rectal cancer. Int J Radiat Oncol Biol Phys. 2002 Oct 1;54(2):403-8.
Twelves C, Boyer M, Findlay M, Cassidy J, Weitzel C, Barker C, Osterwalder B, Jamieson C, Hieke K; Xeloda Colorectal Cancer Study Group. Capecitabine (Xeloda) improves medical resource use compared with 5-fluorouracil plus leucovorin in a phase III trial conducted in patients with advanced colorectal carcinoma. Eur J Cancer. 2001 Mar;37(5):597-604.
Jansman FG, Postma MJ, van Hartskamp D, Willemse PH, Brouwers JR. Cost-benefit analysis of capecitabine versus 5-fluorouracil/leucovorin in the treatment of colorectal cancer in the Netherlands. Clin Ther. 2004 Apr;26(4):579-89.
|Responsible Party:
|Prof.assist. Vaneja Velenik, MD, PhD, Institute of Oncology
|ClinicalTrials.gov Identifier:
|NCT01152710 History of Changes
|Other Study ID Numbers:
|First Submitted:
|June 25, 2010
|First Posted:
|June 29, 2010
|Last Update Posted:
|June 29, 2010
|Last Verified:
|June 2010
Keywords provided by Institute of Oncology Ljubljana:
rectal cancer
phase II study
Additional relevant MeSH terms:
Rectal Neoplasms
Colorectal Neoplasms
Intestinal Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Digestive System Diseases
Gastrointestinal Diseases
Intestinal Diseases
Rectal Diseases
Antimetabolites, Antineoplastic
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents


text:
Zoning Systems in Fayetteville and Raleigh, NC
You want your house to feel cool in the summer. But you don't need every part of it to stay cool. The places you lounge and sleep might take priority over your kitchen or bathroom.
At Cape Fear Air Conditioning & Heating, Inc., our technicians can install a state-of-the-art zoning system to increase your home's comfort and energy efficiency.
Why a Zoning System Might Be Right for You
Picture your home in different sections. With a zoning system, you can control how much heat or air conditioning goes into each of the zones areas.
Certain sections of your house, by nature of where they are, accumulate more heat. For example, an upstairs bedroom feel warmer than your office downstairs because heat rises. Zoning systems can level these differences in temperature. The technicians at Cape Fear Air Conditioning & Heating, Inc. can customize your new zoning system to your Fayetteville or Raleigh, NC home, giving you complete control your home's temperature.
Enjoy Greater Energy Efficiency
Zoning systems enable you to reduce your energy bill. If you don't need certain sections of your house air conditioned, such as a guest room, your zoning system will concentrate the central air elsewhere. As you minimize the use of air conditioning in lesser-visited parts of your home, your energy efficiency will increase and your energy bill will decrease.
Contact Us to Learn More
Since 1973, Cape Fear Air Conditioning & Heating, Inc. has been increasing the comfort and energy efficiency of Fayetteville and Raleigh area homes. We're a family-owned and operated business that believes in customer satisfaction. Our technicians offer round-the-clock emergency service every day of the week, including holidays. We also provide same-day service.
For more information about zoning systems in Fayetteville, North Carolina, call us at (910) 483-8790 or Raleigh at (919) 322-2000.
"Call Today, Service Today!"
Please visit Trane to see more great products.

subset: commoncrawl


text: I am meeting up with a friend in San Diego that I have not seen in five years, and she has two little ones around 5 years old. I am searching for the best family friendly restaurant in San Diego. Please leave me some recommendations. I don't have any kids, and she is not from the area, so we are lost. Thanks so much chowhounders.


text:
Frodo's Pizza isn't a bar at all. It is, in fact, a pizza restaurant.
A family pizza restaurant.
I heard the distinct sound effects from Ms. Pacman when I walked in. Then I saw the counter where a family of six was placing an order.
There were no bar stools, no bar, no stage. This little pizzeria in Greenville, S.C., looked more like a Zaxby's than the 40 Watt.
But this was the venue for my first solo gig, my return to the music scene. I was but a stranger in a foreign land, strumming a guitar that didn't belong to me and singing a few songs that do.
The guitar belonged to Monte Dutton, a fellow NASCAR writer who also pens songs in his free time. Monte and I decided after swapping several of our tunes at Daytona two years ago that we needed to play a show together sometime.
Last Friday, the time finally came. Monte was playing two sets and needed someone to fill about a 30-minute gap in between them. He called me.
I spent about five seconds deciding if I should play - I said yes, hence the column - and the next two weeks worrying about the opportunity I had gotten myself into.
I picked up a guitar for the first time six years ago, and I've played in three bands. In each of those bands, I surrounded myself with talented musicians who covered up my shortcomings.
I still lack in the talent department. My guitar playing is functional at best, and my voice is flatter than a half-full bottle of Coke left uncapped overnight.
On Friday night, I had nothing but the words in my songs to distract the growing, talkative crowd from my warts. I drank a beer and a half, grabbed Monte's Taylor acoustic and stepped to the microphone in the corner of the restaurant.
"How's everyone doing tonight?" I started off.
No response.
"Alright. Fantastic."
Still nothing.
"And this is the part of the show where I'd like to play you a song."
At that moment, I realized that I should have made a set list. I had only a handful of songs to play, but my nerves erased any plan I had in my mind.
One bad move away from a full panic attack, I strummed a G-chord. The Taylor sounded sweet and warm. I went right into "The Night the Train Came to Town," a cornerstone of my song catalogue.
I spent the next 30 minutes in a twilight state of mind. I can't even remember the five songs I played, but I do remember the following:
I never dropped my guitar pick.
I also remember a much more important detail, one that all great musicians know and love. As I kept playing, the noise of talking in the room diminished. People actually were listening - and not throwing any bottles at me.
My goodness, I forgot what a special feeling that reaction brings with it.
I finished playing, shook Monte's hand and resumed drinking that second beer. A few minutes later, the owner of Frodo's walked up and invited me to come back and play longer sometime.
That invite got me thinking: Maybe it's time for me to play a little show here. If you run a small bar with minimal sound equipment and no expectations, I may be the act for you.
I still can't really sing or play. But Friday night, I fooled a crowd of people into thinking I can.
I even fooled myself.
• VanHoose is the features reporter for the Athens Banner-Herald. He can be reached at email@example.com.
© 2017. All Rights Reserved. | Contact Us


text:
The Invaders: 20 Years Later Trailer (1995)
"They are among us" 12 November 1995 Sci-Fi, TV Movie 180 mins
They look like us. They sound like us. And they've come with a hidden agenda of global proportions in this sci-fi thriller based on the popular 1960's cult series. Scott Bakula stars as Nolan Wood, a pilot who uncovers a plot to promote the ecological destruction of Earth in order to pave the way for alien colonization. Now, with the help of a dedicated, open-minded doctor (Elizabeth Pena), Wood embarks on a desperate race to convince authorities of this conspiracy--while staying one step ahead of his alien pursuer--in this cautionary tale.
Watch the official The Invaders: 20 Years Later 1995 trailer in HD below or find more The Invaders: 20 Years Later videos on Vidimovie.


text:
ROCK star Noel Gallagher has revealed he struggled with fatherhood and family
– until second wife Sara MacDonald taught him how real families work.
The ex Oasis star, whose dad left mum Peggy to bring up him and brothers Liam
and Paul, admits he didn't know how to parent.
Speaking in BBC4's Mark Lawson Talks To Noel Gallagher, the dad of three said:
"I had never seen a good example of any parenting until I met Sara, who is
an incredible mother to the children."
Noel has two sons with Sara — Donovan, four, and Sonny, 17 months — and
daughter Anais, 12, with first wife Meg Mathews.
He added: "I have learnt so much from her as she has great parents. Her mum
and dad have been married for 150 years or something and they are still
together. And she takes that and brings that to our children.
"I come from a dysfunctional family. I'm good with the kids now but at first,
with my older daughter, I didn't have the tools instinctively." He also
talked about his mother Peggy and estranged father Thomas — who separated
when Noel was 15 — and his spats with younger brother Liam.
Of Peggy he said: "We were three lads and it was tricky for her bringing us up
on our own.
"She gave it all up for us. I think she has great karma and two of her
children became two of the biggest rock stars that England ever produced.
"All she got was a new garden gate from us. Liam offered to buy her a castle
in Alderley Edge but the gate at her council house had been squeaking and
she wanted that fixed.
"She still lives there and we changed it and put a gold number 5 on the gate.
"I don't think of my father at all. It's his loss, not mine."
Oasis notched up eight UK number one albums and eight chart-topping singles,
the first Some Might Say in 1995. But Noel and Liam fell out in 2009 and the
band split.
And Noel said of Liam: "There is no contact of any significance, to my
mother's disgust. But we are big boys now. She can't tell us what to do for
"It's not the last time I'm ever going to speak to him. Of course I'm going to
speak to him again but I'm busy."
Watch the full interview on BBC4 at 11.20pm on March 30.


text:
Detalii loc de munca - Hautes-Alpes
Descrierea jobului - Belgia
CANDIDATUL IDEAL: We are looking for a hard-working, exceptional personality who can create an outstanding atmosphere as a waiter/waitress in our warm, welcoming traditional restaurant in the Hautes-Alpes. You'll be working and having fun with an international team. Minimum 2 times a week night shift required
Requirements: minimum 3 years of experience in a busy restaurant, outstanding personality, team player, fluent English Duration: December-April. Long-term, all year round (summer-winter season) career offered for the right person.


text:
Jan 27 & 28
E-Mental Health Conference
Robert H. Lee Alumni Centre, 6163 University Blvd
Feb 1
Work in Progress Seminar:
Lung Health in B.C. First Nations
Drs. Pat Camp and Karen Bartlett
12:00 PM–1:00 PM, Hurlburt Auditorium, St. Paul's
Feb 15
Work in Progress Seminar
Dr. Jason Sutherland
12:00 PM–1:00 PM, Hurlburt Auditorium, St. Paul's
Mar 1
Work in Progress Seminar
Dr. Michael Krausz
12:00 PM–1:00 PM, Hurlburt Auditorium, St. Paul's
Mar 16
Clinical Research Education Lunch and Learn
11:45 AM–1:15 PM, Dining Rooms 1&2, Providence Bldg, St. Paul's
Jan 25
Workshop: Introduction to Health Economics
1:00 PM–4:30 PM, C2E2, 828 West 10th Avenue
Jan 27
Patient-Oriented Research
B.C. SPOR SUPPORT Unit
12:00 PM–1:00 PM, Via Webinar
Jan 27
SPPH Grand Rounds: Tackling Poverty and Socioeconomic Inequities
9:00 AM–10:00 AM, Michael Smith Labs, 2185 East Mall
Feb 22
Priority Setting in Health Care: Practical Approaches
1:00 PM–4:30 PM, C2E2, 828 West 10th Avenue
Mar 8
Statistics Makeover: Graphical Displays
1:00 PM–4:30 PM, C2E2, 828 West 10th Avenue
Mar 15 to 18
Heart + Lung Health FEST 2017
Sheraton Wall Centre Hotel, 1088 Burrard St
Mar 16
Establishing and Maintaining Ethical International Partnerships for Research and Education
9:00 AM–10:00 AM, Via Webinar
Mar 27
PHC Interprofessional Research Celebration
1:30 PM–4:00 PM, Hurlburt Auditorium, St. Paul's
All times are in Pacific Standard Time (PST) unless otherwise indicated.
Students, residents and fellows are invited to submit their poster abstracts for the 2017 Heart + Lung FEST, taking place March 15–18 in Vancouver. The deadline for submissions is March 1. Visit the FEST website for more information.
We would like to welcome two new CHÉOS scientists: Drs. Caren Rose and Annalijn Conklin!
Dr. Rose (left) completed a Master of Science in Statistics at Dalhousie University, and a PhD in Health Services and Epidemiology at UBC's School of Population and Public Health. Her doctoral program of research focused on contemporary challenges in deceased donor kidney allocation. Dr. Rose is a member of the UBC Division of Nephrology, where she focuses on health services and policy research related to kidney transplantation and organ donation. Dr. Rose will be giving a presentation as part of our Work in Progress (WiP) Seminar Series on May 24.
Dr. Conklin is a former CIHR Postdoctoral Fellow at UCLA's WORLD Policy Analysis Center following the completion of her PhD from the University of Cambridge. She also holds a research Master of Science from the University of Edinburgh, and a Master of Public Health from Columbia University. Dr. Conklin's research examines the broader social-level factors that influence nutrition-related behaviours and outcomes among adult populations, with a strong policy interest in better designing and evaluating interventions to prevent and manage chronic conditions. She presented the first WiP Seminar of 2017 on January 18.
Dr. Wei Zhang, CHÉOS Health Economics Program Head, discusses the importance of conducting health economic evaluations in this Business in Vancouver article.
CHÉOS Scientists Drs. Nick Bansback, Mark Harrison, Patricia Spittal, Martin Schechter, and Jason Sutherland are featured in the latest edition of The Evidence Speaks, a monthly snapshot of the latest publications by our investigators.
Our investigators were mentioned in 14 news stories from November to January. Read the articles below and in our media summaries here and here.
"What it's like to be forced to take anti-psychotic drugs." VICE. Dr. Michael Krausz. December 20, 2016.
"Meet and Greet: Ms. Aggie Black." PHC News. Ms. Aggie Black. January 5, 2017.
"Are patient engagement groups missing minority voices?" Healthy Debate. Dr. Beth Snow. January 12, 2017.
"Moral distress in the intensive care unit." CARENET. Dr. Peter Dodek. January 13, 2017.
CHÉOS Scientist Dr. Linda Li is assessing the public's knowledge and opinions about the use of "Big Data" in Canadian health research through an online survey. Take the survey today.
UBC Alumni Achievement Awards. Deadline January 27.
MSFHR Aubrey J. Tingle Prize. Deadline January 31.
UBC 2017 Killam Teaching Prize. Deadline February 17.
IHSPR Article of the Year Award. Deadline February 24.
MSFHR Research Trainee Award. Deadline March 6.
Genome Canada Large-Scale Applied Research Competition—Genomics and Precision Health. Deadline March (date TBA).
Please extend a warm welcome to three new team members: Pattie Shang and Sonia Kwong joined the CIHR Canadian HIV Trials Network Communications team as UBC Arts Interns, and Vassi Sharlandjieva joined CHÉOS as a Communications Assistant.
We would also like to thank Danielle Arsenau for her work and wish her luck in her future endeavours.


text:
Dickinson Dees" class="inline_image inline_image_left" src="/pictures/web/images/15290_P15_cv.jpg" />What was your first-ever job?
Trainee solicitor.
What was your worst experience as a trainee?
Leaving a corporate completion meeting with the client's jacket and the consideration cheque for £5m. (Inadvertently – he took my jacket.)
Where's the best place to go if you want to find out what's really going on in the office?
Jen and Anna's office, next door.
What time do you usually leave the office?
What do you do at weekends?
Walk in the hills or along the coast. Meet friends for dinner. Swim or cycle.
What's your favourite restaurant?
Pani's, Newcastle's quintessential Italian café.
If you weren't a lawyer, what would you have been?
Talent aside, an architect, yachtsman or landscape gardener.
Who's your hero and why?
The Dalai Lama, for his humility and inexhaustible supply of compassion.
What's the best thing about your job?
Dickinson Dees is a firm full of great people, the work is extremely varied and interesting, and I love living in Newcastle.
What's the toughest thing about your job?
Sitting at a desk for too many hours.
What's your biggest work/career mistake and what did you learn from it?
Can't think of any biggies.
What car do you drive?
A red BMW coupé. (I am not, as a friend enquired, having an affair, nor a
mid-life crisis.)
What book are you currently reading?
The Human Touch by Michael Frayn.
What's on your iPod at the moment?
A vast eclectic mix of music, but if I could only have one piece on it, it would be Keith Jarrett's The Koln Concert. Magical.
What's your favourite children's book?
Shel Silverstein's The Giving Tree – a eulogy to selflessness.
What's the most exciting deal/case you've worked on and why?
Helping a client avoid a vexatious prosecution under the Wildlife & Countryside Act.
If you were stranded on a desert island, what two luxury items would you take?
Prescription swimming goggles and an iPod.
What's the longest you've worked without sleep?
Two days.
If a movie was being made of your life, which actor would play you and why?
John Travolta, circa 1978. He copied my strut, so he's halfway there.
Name: Stuart Wardlaw
Firm: Dickinson Dees
Title: Partner
Lives: Cleadon, Tyne and Wear
1992-93: BA Hons Geography, Oxford University
1993-94: CPE, LPC, Northumbria University
Work history:
1994-96: Trainee solicitor, Dickinson Dees
1997: Directory researcher, Chambers and Partners
1997-98: Solicitor, SJ Berwin
1998-2000: Solicitor, Nabarro Nathanson (Sheffield)
2001-06: Associate solicitor/director, environment and safety team, Dickinson Dees
2007-present: Partner, head of environment and safety team, Dickinson Dees


text:
My Family is about Kajal (Renuka Shahane), a single parent to her son Varun (Dastur Parzan), and they love each other. Her friend Dipti (Loveleen Mishra) introduces her friend Rohit (Sudanshu Pandey) to Kajal, who is already in love with her. Kajal is reluctant to entertain a man in the house because of Varun s insecure feelings. Rohit somehow tries to befriend Varun, but does not succeed. Varun is very possessive about his mother and does not like the idea of sharing her with Rohit. Kajal forbids Rohit from coming home although she is in love with him. Rohit comes to bid them goodbye but he has a surprise in store!
Rishtey mirrors life and brings to the forefront, various nuances of human
relationships. Each episode delves into the intricate lives of the characters,
their circumstances and their deepest emotions in a manner that will touch your
Episode :166
Date: 2001-06-24
Episode :165
Date: 2001-06-17
Episode :164
Date: 2001-06-10


text:
GraphicRiver New Years Eve Flyer 6382593
Category: Print Template | Comment: ( 0 )
GraphicRiver New Years Eve Flyer 6382593
Print Template \ Flyers \ Events \ Holidays
Template \ Photoshop \ Santa \ Templated \ Graphic \ Year \ Invitation \ Layered
Print Template - New Years Eve Flyer 6382593 by scarab13 @ GraphicRiver
Print Template \ Flyers \ Events \ Holidays
Graphics Files Included: Photoshop PSD ; Layered: Yes ; Minimum Adobe CS Version: CS2 ; Print Dimensions: 4x6 .
Very airy, light and modern NYE flyer, just insert your image (right click on the image holder layer marked in red and choose "Edit contents", then paste your image in the layer "paste image here". Save and it will update the main file. Resize and position as needed. You can paint on the Image Holder's mask (little black and white thumbnail next to it) in black to hide details or in white to show more details.
Fonts used.
- ITC AvantGarde Gothic Bold ( http://www.myfonts.com/fonts/linotype/itc-avant-garde-gothic/bold/)
- Bebas Neue ( http://www.fontsquirrel.com/fonts/bebas-neue)
- Baskerville ( http://www.fontshop.com/fonts/downloads/urw/baskerville_ot/?gclid=CK3V8M2vtbsCFa9aMgodIG4AAA) – It's similar to Trajan Pro so you can substitute it.
Shirt Model Mockup; Photo To Typography treatment; Versatile Poster Design in 5"x7" ; Splash Image Treatment; 8.5"x11" Grunge, Splashy Poster Template; Poster Design; Layered SmartPhone Mockup in 3 Colors.
Keywords: holiday invitation, layered psd, new year, nye, photoshop template, santa, templated graphic.


text:
"I don't write for search engines. I write for people."
Said by copywriters all over the web—in forums, blogs, and social media posts.
Fellow writers, that is not something to be proud of. Because here's the thing: people use search engines.
Why would you not want your content to be found?
Deliberately choosing to NOT cater to search engines is the easy way out. I'm convinced that writers do this because they don't know HOW to cater search engines, and are intimidated to try. It's much simpler to get a little haughty about the subject and feel purposefully in the dark.
Trust me, I've been guilty of this.
I've written my share of online content that lacked direction and failed every SEO checklist on the web. But that was back in the day.
Now, I know that not writing for search engines is a little idiotic, because search engines are used by people.
Good SEO copywriting helps search engines out with quality control
Here's the thing: Google is on top for a reason. It's the best place to go when you're looking for anything. How many times a day do you Google something? I'm not sure of my own average, but between work and personal life, it would have to be at least 10 times a day. Probably more like 30, since I'm one of the lazy people who doesn't write .com on the end of anything and instead clicks through to the site I already knew I was going for.
If you've ever run a Google Adwords campaign, then you know what a quality score is. The quality score is a mix of many metrics, but let's focus on two of them right now: keyword relevancy and on-page experience.
When a quality score really sucks, Google stops displaying the ad.
Many people outside of advertising are surprised to hear that. They assume Google will take anyone's money any time of the day.
But if Google did that, then their search platform would go to shit.
People would click through to spammy, low-quality sites that loaded incredibly slowly or did something far, far worse.
If Google only concerned themselves with making money off ads in the short run, then they would no longer be able to serve their true customers (namely, the entire world) in the long run.
Searchers would have a bad experience with ads, and would either no longer click on any of them or would take their searches elsewhere.
The same holds true for organic results, in a way. If Google doesn't give people what they want, they'll leave.
If Google can't make sense of your content and doesn't trust your site, it won't serve your posts or pages to their searchers.
So, by using SEO best practices, you're putting yourself on Google's good side and helping them…
- Maintain the quality of the search platform
- Deliver the right content to the right people
Ultimately, you win too.
Of course, things will change
"Writing for search engines" still has a bad connotation.
When I first started offering content marketing as a service, I was given misspelled keywords—on purpose. And that was less than two years ago.
Newsflash: purposefully using misspelled and ungrammatical sentences to capture search traffic is no longer recommended, and I'm not sure it ever was.
As Google gets smarter, seo copywriters get to up their own quality control.
You don't need to worry about keyword density or keyword stuffing. So if "writing for search engines" makes you sneer, you probably need to brush up on what matters to Google today. Tactics that once worked will now work against you.
Smart copywriters write for search engines in every way they can, including image search. Again: why wouldn't you want people to find your in-text images? Putting the right keyphrases in images, headlines, headings, and URLs is still a must for getting your content found.
It will all be worth it
I get really excited when I get a client to page 1 of the Google search engine results page for a given keyphrase.
Each and every relevant keyphrase that you position for is a victory.
Sometimes these keyphrases are highly targeted and payoff big. Sometimes they are relevant to a target audience who may or may not ever circle back to the website again. But considering that converting someone typically takes multiple touchpoints (particularly with SaaS) then every piece of content read by the right audience makes up part of the win.
Is your blog actually bringing in customers? Let's talk about targeted content for your site.


text:
Elite coach Zaur Antia turns down six-figure salary to stay with Ireland
Irish head coach Zaur Antia is understood to have turned down a lucrative offer from Azerbaijan to remain at the helm with Ireland.
As reported in the Irish Independent, Antia was offered a substantial six-figure salary, which would have doubled his wage, to lead Azerbaijan to the Tokyo 2020 Olympics.
The Georgia-born coach, who has been with the Irish Athletic Boxing Association (IABA) High Performance Unit for over a decade, enjoys a well-earned reputation as one of the best technical coaches in the world.
Based in Bray, he was the subject of speculation linking him with positions in the Americas and the Middle East immediately after Rio.
"I think I will stay, but we'll see. I want the team to get more respect, this is a great team and they deserve respect," Antia said at the time.
Under Antia, Ireland failed to medal at Rio 2016, with the eight-strong squad, touted as the greatest Irish boxing side to enter the Olympics, winning just four fights between them.
Ireland did, however, still win 17 medals in World and European competition in 2016
With Antia as head coach, three of those medals were won at Elite level, with Kellie Harrington and Taylor winning world silver and bronze and Christina Desmond of Cork winning European bronze.
Irish Independent


text:
Traveling Luck for Blue Spring (historical), Alabama, United States
Where is Blue Spring (historical)?What's around Blue Spring (historical)?
Wikipedia near Blue Spring (historical)
Where to stay near Blue Spring (historical)
The timezone in Blue Spring (historical) is America/Iqaluit
Sunrise at 08:25 and Sunset at 18:38. It's light
Latitude. 34.6283°, Longitude. -86.6533° , Elevation. 190m
Weather near Blue Spring (historical); Report from REDSTONE ARSENAL, null 8.5km away
Weather :
Temperature: 17°C / 63°F
Wind: 5.8km/h West
Cloud: Sky Clear
Weather :
Temperature: 17°C / 63°F
Wind: 5.8km/h West
Cloud: Sky Clear
Satellite map around Blue Spring (historical)
Loading map of Blue Spring (historical) and it's surroudings
Geographic features & Photographs around Blue Spring (historical), in Alabama, United States
- cemetery;
- a burial place or ground.
- Jordan Cemetery (1.2km)
- Lanier Cemetery (2km)
- Lanier Cemetery (2.2km)
- Jordan Cemetery (2.2km)
- Fennil Cemetery (2.7km)
- Simpson Cemetery (3.8km)
- Clark Cemetery (3.8km)
- Moore Cemetery (3.8km)
- Simpson Cemetery (4.7km)
- Penland-Cooper Cemetery (5.3km)
- Jordan-Lanier Cemetery (5.3km)
- Burton Cemetery (5.8km)
- Lynch Cemetery (5.9km)
- Powhatan-Toney Cemetery (6km)
- Gowan Cemetery (6.1km)
- Timmons Cemetery (6.5km)
- Horton-Joiner Cemetery (6.8km)
- Dickson Cemetery (6.8km)
- Groves Cemetery (6.8km)
- Landman Cemetery (7.1km)
- Joiner Cemetery (7.4km)
- Hancock Cemetery (7.5km)
- Lacey Cemetery (7.6km)
- Lanier Cemetery (7.6km)
- Lipscomb Cemetery (7.7km)
- Tate Cemetery (7.9km)
- Williams Cemetery (8km)
- Jones Cemetery (8.1km)
- Arnett Cemetery (8.1km)
- Local Feature;
- A Nearby feature worthy of being marked on a map..
- Blue Spring (historical) (0km)
- Pinegrove Church (historical) (1.9km)
- Center Grove Church (historical) (3.8km)
- Pine Tree Church (historical) (3.9km)
- Cedar Hill Church (historical) (5.3km)
- Green Grove Church (historical) (6.1km)
- Cedar Grove Church (historical) (6.2km)
- Green Grove (historical) (7.5km)
- Slaughter Ferry (historical) (7.7km)
- North Park Center Shopping Center (8.1km)
- mountain;
- an elevation standing high above the surrounding area with small summit area, steep slopes and local relief of 300m or more.
- Madkin Mountain (5.5km)
- Hatton Mountain (6.3km)
- Hatton Mountain (7.2km)
- Bradford Mountain (7.4km)
- Weeden Mountain (7.8km)
- lake;
- a large inland body of standing water.
- Cribbs Pond (3.8km)
- Lees Pond (4.5km)
- Rock Pond (5.1km)
- Swan Pond (7km)
- school;
- building(s) where instruction in one or more branches of knowledge takes place.
- Silver Hill School (historical) (1.5km)
- Hickory Grove School (historical) (4.9km)
- Horton School (historical) (5.9km)
- Poplar Hill School (historical) (6.2km)
Accommodation around Blue Spring (historical)
- stream;
- a body of running water moving to a lower level in a channel on land.
- Huntsville Spring Branch (4.8km)
- Byrd Spring Branch (6.1km)
- Crowder Slough (7.6km)
- church;
- a building for public Christian worship.
- Spring Hill Church (8km)
- spring(s);
- a place where ground water flows naturally out of the ground.
- Mullins Big Spring (5.1km)
- populated place;
- a city, town, village, or other agglomeration of buildings where people live and work.
- Slaughter Landing (7.9km)
- reservoir(s);
- an artificial pond or lake.
- Byrd Spring Lake (6.5km)
- bar;
- a shallow ridge or mound of coarse unconsolidated material in a stream channel, at the mouth of a stream, estuary, or lagoon and in the wave-break zone along coasts.
- Lees Bar (historical) (7.3km)
- park;
- an area, often of forested land, maintained as a place of beauty, or for recreation.
- Redstone Arsenal Recreation Area (6.9km)
Wikipedia entries close to
Blue Spring (historical)
- Redstone Arsenal city city m
- Redstone Army Airfield airport airport
- Triana, Alabama city city o
- United States Space & Rocket Center landmark sport
- Huntsville (Alabama) city city e
- Huntsville-Decatur Combined Statistical Area city city o
- Anniston-Oxford Metropolitan Area city city o
- Huntsville International Airport airport airport
- Madison (Alabama) city city h
- Maple Hill Cemetery (Huntsville, Alabama) cemetery
- Madison County (Alabama) adm2nd adm2nd
- Owens Cross Roads, Alabama city city o
- Mooresville, Alabama city city o
- Somerville, Alabama city city o
- Priceville, Alabama city city o
- New Hope, Alabama city city o
Airports close to Blue Spring (historical)
Redstone aaf(HUA), Redstone, Usa (7.9km)
Birmingham international(BHM), Birmingham, Usa (150.9km)
Anniston metropolitan(ANB), Anniston, Usa (174.1km)
Lovell fld(CHA), Chattanooga, Usa (177.1km)


text:
Today's second scheduled auction of Anthology has been postponed. The new auction date is April 30.
This marks the second consecutive postponement of the auction of the upscale downtown concert venue and supper club. Anthology abruptly closed on Jan. 1, after nearly six years of operations, and was initially scheduled to be auctioned March 15. The venue featured national jazz, pop, rock, blues, country and folk-music artists.
The March 15 auction was postponed following a Chapter 11 bankruptcy filed in court on March 14 by India Street Ventures LLC, Anthology's current owner.
India Street Ventures has indicated it owes creditors an estimated $3.6 million, based on a March 28 bankruptcy record, which includes taxes owed and secured and unsecured debts.
Its creditors include Pacific Western Bank and the U.S. Small Business Administration, although there may be other potential creditors who step forward. Currently in dispute, according to public documents, is a $21.5 million construction loan with Key Bank N.A. That loan was used to build the mixed-use building where Anthology is located.
The postponement of today's auction came as no surprise to Pasquale Buono. Together with three business partners, he has been actively seeking to purchase Anthology since late last fall. It was then that Anthology's original owners, Howard and Marsha Berkson, quietly launched a national search to find new owners.
Today, Buono expressed doubt that the new April 30 auction would take place as planned.
"I don't feel it will happen. I think it will get postponed again," he said.
"(Today's) auction was postponed because the bank couldn't get relief from the stay (on the proposed sale). You have to go to the judge if you hold the trust deed and want to get relief from the stay, and they were not able to get it."
The new April 30 auction date comes just one week before a scheduled April 23 meeting at which Anthology's creditors. The meeting is designed to give the creditors a preliminary idea of India Street Ventures' financial state and to provide a sense of whether they'll get paid for the monies owed them.
"Bankruptcy is a process and (Anthology) they have to give the creditors their moment to ask any questions they may have of Howard (Berkson)," Buono said.
"The more these (auction) postponements happens, the deal gets a little more hairy, and it was hairy to begin with. People are scrambling with their money (to make a bid at the auction) – wondering: 'Is there going to be a sale (this time)?' "
Assuming the third auction goes off without a hitch, items on the selling block include the building on India Street, the club's business license, and all the furnishings, including the state-of-the-art video and sound systems. Anthology's Yamaha grand piano was apparently removed from the venue sometime after the venue's Jan. 1 closing.


text:
Spend 11 unforgettable days in Bulgaria on a legendary BBYO summer experience that combines cross-cultural bonding, service learning, and travel adventures.
Be part of a close-knit group of teens from Bulgaria, North America and from across Europe on a journey of service, community and adventure.
With the country of Bulgaria as the backdrop, join with Jewish teens from North America and Europe for an unforgettable experience full of exploration, exchange, unique opportunities, adventure and excitement! You'll share values and traditions, learn how to empower yourself – and others – to advocate and take action. Return home as an Ambassador to the global Jewish community!
Travel from city to city and village to village, leaving your mark through hands-on service projects such as restoring local synagogues, volunteering at a Jewish seniors' home, and helping to feed the hungry. You'll touch the lives of those in need and enrich your cultural understanding along the way.
Share in the entire experience with Jewish teens from Bulgaria, Bosnia and Herzegovina, Estonia, Latvia, Lithuania, Macedonia, Serbia, the United Kingdom and more! Exchange perspectives and experiences as you live the Jewish value of Kol Yisrael Arevim Ze La Ze (we're all responsible for one another).
Considered a hidden jewel of Europe, you'll explore the capital city of Sofia, relax on the beaches of the Black Sea and discover many colorful small villages and towns in between. Bulgaria is a country rich in history with a remarkable Jewish story waiting to be shared.
For nearly two decades, BBYO has organized missions of service and community bonding to Bulgaria. We're proud to have a thriving local chapter in Bulgaria, and BBYO Bulgaria along with the American Jewish Joint Distribution Committee (JDC) are key partners in making this exceptional cross-cultural experience possible.
For a more detailed view of the program, check out the Program Itinerary
Discover the rich history and customs of Bulgarian Jewry in Sofia and Plovdiv
Share the experience with fellow Jewish teens from Bulgaria and many other European countries
Explore Bulgaria's small towns and beautiful countryside
Tour Sofia, Bulgaria's capital, and explore 2,000 years of history
Swim in the Black Sea, the gateway between Southeastern Europe and Western Asia
Enjoy the warmth of Shabbat in a small European Jewish community
Contribute to the upkeep and well being of Sofia's Jewish residents and their communal institutions
Build lifelong friendships with teens from around the world
We have provided the following sample itinerary to give you a better feel for this experience, including the types of accommodations we use. The actual program may vary slightly. An updated itinerary is distributed 3-4 weeks prior to the start of the program.
You have questions? We've got answers! Our most frequently asked questions for this program are answered below. Additional program-wide FAQs are also available. Contact us to learn more.
BBYO makes it easy to combine two experiences for an extended summer of adventure, learning and self-discovery.


text:
Bruised Dogs stand tall: Gibson has career day as two offensive linemen injured
Georgia's David Pollack attempts to tackle Kentucky quarterback Jared Lorenzen on Saturday. Lorenzen proved to be a difficult man to bring down.
Jeff Blake/Staff
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text: Special Message from the VP of Human Resources: Extraordinary Service is Our Goal October 17, 2016 I started with Wright-Patt Credit Union (WPCU) in April of this year, and the first thing we talked about in New Hire Orientation was that delivering extraordinary service to our members is our priority. We believe extraordinary member service means providing members accurate, efficient, friendly and professional service, building strong relationships, and handling issues quickly. We understand that extraordinary service is the best way to keep our members coming back! Building extraordinary member service begins at the time of hire. Effective recruiting is an essential part of any business and it pays to do it properly. Wright-Patt Credit Union believes when we choose the right partner-employee for the job, train them well,... Full story


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Results 1 to 2 of 2
11-26-03, 13:31 #1Registered User
- Join Date
- Nov 2003
- Posts
- 1
Unanswered: Passing form data to Access query
This seems simple enough but I can't figure it out.
I have a series of queries - maybe 15 in all. Each has a field as follows:
Field: Net: ([DB_amount_11]+[cr_amount_11])
Total: Sum
Each month I have to manually change the Net field to reflect the current month. ([DB_amount_12]+[cr_amount_12])
What I tried to do without success is create a form so I could change the month just once (on the form) and the queries would all update.
When I do this, instead of getting a value in the Net field, I get:
The question: is there a way to do this in the query design window? Or do I need to do this using VBA/SQL.
Thanks in advance for your assistance - I appreciate it
11-26-03, 19:01 #2Registered User
- Join Date
- Nov 2003
- Posts
- 267
What I would do is set up my queries so that on the form I enter which month I want and have the data pull formt he different fields that relate to the month I chose.
In you if statemtn you would look at the value you passed to the query and..
Select iif([forms]![frmName]![Fieldname] =11, (Table1.[DB_amount_11]+Table1.[cr_amount_11]), [forms]![frmName]![Fieldname] = 12, (Table1.[DB_amount_12]+Table1.[cr_amount_12]), 0))as Net
From Table1
I will let you work out the proper syntax, but it isn't to hard.


text:
BOULDER — InvitedHome, a vacation-home-rental company that specializes in luxury houses, developed a new platform to make it easier for homeowners to monitor the abodes they are renting out.
The Boulder company released HomeCraft, a dashboard that lets the owners of the vacation homes see when their home is being used, how much revenue they're bringing in and when the house needs a capital improvement, among other features.
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The decision to develop HomeCraft is to increase transparency among InvitedHome and the homeowners the company works with, said Wendy Purvey, chief marketing officer for InvitedHome.
"The average sale prices of our homes is $2 million," Purvey told BizWest in a phone interview. "We very much stay in that resort market. These are second homes where the owner may live in New York but have a home in Telluride and use it twice a year. We want to make sure it's ready for them, it's their home. We make sure the pillows are in the right place and it doesn't look like people are in and out of their home. And we're very much about transparency with them."
The dashboard lets the company log everything that is happening with the property, and lets the homeowner forecast how much money they might make if they rent their home out at any given time — helping them to decide whether they want to use their house that weekend or rent it out.
In addition to the HomeCraft dashboard, Purvey said InvitedHome also offers a virtual binder for guests, which details every instruction they need to use the appliances on the property.
Purvey added that InvitedHome gets its revenue from getting a percent of what the guests pay to use the houses.
HomeCraft has been several years in the making.
"The HomeCraft concept has been in the works for many years," said Tom Feldhusen, chief product officer of InvitedHome, in an email to BizWest. "With over one million dollars in investment capital, we've brought it to life and created a huge point of differentiation in the vacation rental space."
Looking ahead, Purvey said the company is focused on growing. In addition to destinations such as Vail, Breckenridge, Lake Tahoe and Maui, InvitedHome added Jackson Hole, Wyo., to its roster and is looking at adding Park City, Utah, next.


text:
I love casseroles.
Comfort food….there's just something about them.
Plus they are usually pretty easy to throw together.
This one is no different….it's incredibly quick and easy.
AND all you need is one bowl…and one baking dish!
That's the best part.
One bowl…..
Literally throw everything in…..and stir….and pour.
Pour into a 13×9 casserole. I doubled the batch this last time (because we love this recipe) so used 2.
I also used one can of tuna and one can of salmon because that's all I had….it was great!
Top with Panko bread crumbs (optional), Parmesan cheese and a sprinkle of Cayenne pepper (also optional).
Bake at 375 for approximately 45 minutes, or until golden and firm.
Sprinkle with the juice of half of a lemon (or more…I like more, lots more!)
The lemon goes so well with all of the flavors in this dish.
The broccoli, the salmon, the hint of Dijon…all of it.
Cut and serve…..and enjoy.
It's really very good. I always eat too much of it when I make it!
It's a perfect one dish, one bowl, super quick and easy meal to throw together.
If you don't like Salmon, you can sub Chicken or any other meat you like.
Here's the recipe.
- 1 cup uncooked rice I used Basmati
- 1 can Cream of Mushroom soup
- 1-1/2 cans of water
- 1/2 cup Parmesan cheese
- 1 small can salmon or any meat
- 1/2 cup plain unsweetened yogurt
- 2/3 cup mayonnaise
- 4 Tbsp Dijon mustard
- 1/2 cup green pepper diced
- 1/4 - 1/2 cup Monterey Jack cheese shredded
- 1 pkg 14 oz broccoli florets
- Lemon Pepper seasoning
- juice of 1/2 lemon
- Panko bread crumbs
- Parmesan Cheese
- Cayenne pepper
Mix all ingredients in a large bowl (except the Panko bread crumbs, extra Parmesan cheese and cayenne pepper)
Mix well and pour into a greased/sprayed casserole dish. (13x9)
Sprinkle the Panko bread crumbs & Parmesan evenly over top. Sprinkle with Cayenne, if desired.
Bake at 375 for approximately 45 minutes.
Sprinkle the juice of 1/2 to 1 lemon over the entire top, cut and serve.
Crushed Ritz crackers can be used in place of the Panko bread crumbs.
I hope you enjoy it as much as we do!! :)
Follow along here! –> Instagram ~ Facebook ~ Pinterest
Sharing with: Tidy Mom
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text:
42,492 ways to enjoy music...
This product is currently not available for purchase
Designed for musicians by musicians, the VP2520 loudspeaker merges incredible versatility and sonic performance with amazing affordability. The VP2520 is supremely portable and well suited for musical applications, and is the natural choice for commercial installation.
Please note, this is a B-Stock item. B-stock items are either ex repair or have previously been returned by another customer. The original boxing and manual may be missing, and there may be some slight signs of usage.Otherwise, the unit operates as new.
This is a great opportunity to buy a fully functioning product at a discounted price, supplied with a one year warranty.
Product Ref: 77689
Superior Sound Quality
Capable of handling input levels up to a staggering 2,000 Watts, the EUROLIVE VP2520 PA loudspeaker delivers truly impressive sound quality. The powerful dual 15" long-excursion drivers crank out big tone in the bottom end and mid-range, while the state-of-the-art 1.75" titanium-diaphragm compression driver delivers crisp and detailed highs. The VP2520's wide frequency bandwidth and extensive dynamic range make it ideal for a multitude of applications.
VP2520's unique trapezoidal design makes it ideal for use in FOH (Front-of-House), as well as floor wedge and side fill monitor applications. Enclosures can also be clustered atop the companion VP1800S subwoofer.
Big Bottom
In order to produce tight, deep bass, a loudspeaker has to move lots of air. EUROLIVE loudspeakers accomplish this by using powerful, long-excursion LF (Low Frequency) drivers that are handmade in our own factory. While some companies are content to use "off-the-shelf" drivers, we custom-design each LF driver to perfectly match each application. The VP2520 features two extremely powerful 15" long-excursion LF drivers in a tuned enclosure, providing massive, tight bass all the way down to 40 Hz.
Pristine Top End
High-frequency (HF) content can easily make or break your performance. Too much and the sound becomes brittle and obnoxious, too little and it sounds muddy and poorly defined. The state-of-the-art 1.75" titanium-diaphragm compression driver delivers natural-sounding high end, with an ultra-wide 80° x 50° sound dispersion pattern.
The Technical Stuff
The VP2520 is capable of extremely high sound pressure levels (96 dB full space 1 W @ 1 m) and provides a 40 Hz to 22 kHz frequency range. Weight is 87.7 lbs (39.8 kg). The internal crossover point is fixed at 2.2 kHz. Both 1/4" and professional-style twist-lock connectors are provided.
Optimized for maximum reliability through the integrated overload-protection circuitry, the VP2520 ensures the ultimate high-frequency driver protection. Designed to stand up to the rigors of the road, the VP2520 is built to last and made to perform!
Once the product is delivered, you have 30 days to decide that you definitely want to keep it. If you decide it is not suitable for any reason, you can return it back to us for replacement or full refund, including standard delivery charges.
All Products are new unless stated, and include a minimum of 2 years warranty.
Some items are only eligible for money back guarantee if they are returned to us unused and sealed in the original packaging, and in the case of software, unregistered. These items include:
We are unable to accept returns of any custom made items designed to work together as a unique package, such as computer system built to a customer's personal specifications. Exceptions may only be possible with prior agreement of the vendor, and may be subject to a cancellation fee.


text:
Gridics announced the successful conclusion of a $1.1 million round of seed funding. The round was led by Dune Road Capital and included noted accredited investors such as John Dyett, Managing Director of Salem Partners, serial entrepreneur Robert Kall, CEO and co-founder of Cien.ai and leading Miami real estate developer Avra Jain. The company, which has raised over $2 million of development capital to date, is focused on further strengthening its product and driving adoption of its Zonar.City application. Gridics, short for Grid Analytics, was founded in 2015 with a vision of combining disparate real estate data sets into a single, hyper-local data platform.
From this platform, the company creates software applications that help users make smarter investment and development decisions while streamlining fractured processes in the real estate world. The patent-pending Zonar.City application, for example, aims to revolutionize the way cities approach zoning and planning analysis while helping to bridge the gap between the private sector development community of architects, developers and attorneys by automating development feasibility analysis and streamlining the lengthy development plan approval process. Read More


text:
Father develops cleaning obsession after cornea transplant
A father developed a cleaning obsession following a cornea transplant that he says "must have come from a woman." Before the operation, Will Palmer, 46, was happy to leave household chores to his partner Sarah Gadsby. However, since the father-of-three had a cornea transplant in March this year he has taken to doing the dusting and washing up and developed an aversion to grime he didn't have before.
Mr Palmer, a financial adviser, said: "Since having the transplant my vision is almost 20/20. I've can now notice every speck of dust and dirt and can't help but have a go at cleaning it up as I go along."Before my vision started to deteriorate my partner had to pester me into doing my bit around the house. Sarah always said I never did enough washing up and hoovering, but now I'm always at it. For some reason seeing the grime gets right on my nerves and I have to do something about it. It started as a joke that I must have been given the cornea of a woman but I really do think it's true.
"There's a reason why men don't clean like this and I think it's because we just don't see the dirt, but I see it everywhere I go."Mr Palmer, who plays tennis, golf and squash, contracted corneal disease Fuchs Dystrophy six years ago. The condition causes cells lining the inner surface of the cornea, the thin layer that covers and protects the iris and pupil and is responsible for two thirds of the eye's vision, to slowly die. This meant that over time the sight in Will's right eye had deteriorated so much that everything appeared cloudy and blurred. It was also sensitive to light. Mr Palmer got a much-needed transplant, which took 40 minutes under local anaesthetic, at the Royal Hallamshire Hospital, Sheffield, South Yorks., after being on the list for just six months. Scientific studies have suggested that up to a third of organ transplant patients believe they have inherited changes in their personalities, preferences and skills from their donors.
PS. My Dad got false teeth and didn't stop talking for two weeks straight. Come to find out he got the wrong teeth, the woman was much happier after she got them back.
thanks to arbroath
thanks to arbroath


text:
The year 2010 will be remembered as when the federal government got involved in how much interchange banks and credit unions earn on their debit card transactions.
As Congress contemplates whether to pass a law regulating debit card interchange, a majority of economists and government officials attending a meeting on the subject agreed that there is no economic basis for the proposed regulatory change.
A lawyer and academic addressing a Washington D.C. meeting on card interchange told attendees that the so-called Durbin amendment should really be called the Walgreens Amendment.
Find out how our readers ranked the top 10 stories of 2010.


text:
Tailored to an ultra-slim fit this ponte blazer projects a modern approach to weekly workwear. Let loose for the weekend, layering the jacket over loose, longline shirts.
For full Delivery & Returns policy: click here
Payment is taken at the time of placing an order. No goods shall be supplied without payment. Goods shall be delivered using by a carrier of Krisp's choosing, however Krisp will attempt to ensure the goods arrive within the timeframe of the Customer's choosing. Carriage will be at cost to the Customer and forms part of the invoice.
For security purposes Krisp does not store any customer credit/debit card details.


text:
GraphicRiver Premium Aperture Presets FX 5671299
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Loudblast - Cross The Threshold - CASSETTE + PATCH (Unisexe)
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text:
So folks, I figure you all deserve an update as to how my vegetarian challenge is going.
As far as dinner and breakfast goes, I've been doing awesome. The last meals I've made with meat were ham for Easter, beef stew for Valentine's Day, and turkey for Christmas (I didn't make it). I've been enjoying lots of beans, although it admittedly has been a little stinky around our house lately, if you know what I mean.. I've been utilizing different cookbooks, like Pasta Revolution, Bean by Bean, and ATK's Healthy Family Cookbook.
However, I did start to feel deprived at work. They recently changed their cafeteria to a quick-service style cafe, so there are no daily specials, just constant, never-changing menu items. Instead of having something different to pick from every day, I had limited myself to just a few vegetarian items (with some of them not being healthy at all): tofu stir-fry, cheese quesadilla, veggie burger, grilled cheese sandwich, make-your-own salad, and veggie wrap. I was getting SO sick of the food (and I wasn't going to start bringing my own lunch because I get free food), I considered ditching the whole vegetarian concept. Plus, I started gaining back the weight I'd lost when I stopped breastfeeding. Scared at the number on the scale and frustrated at my self-imposed diet restriction, I decided to make my own compromise: I can eat meat at lunch only. So, now I eat salads with grilled chicken breast and deli meat sandwiches. Believe me, it's all made all of the difference. I don't feel as deprived, and I'm losing that weight (but that's a different story anyways).
Graham and I have come to the conclusion that we don't even really feel deprived with our dinner choices, which has definitely been an adaptation. We've made the change to "mostly meatless", which I am absolutely happy about. I eat less fast food, I try to choose more organic and natural forms of foods, I only eat hamburgers twice a year (which is definitely a big thing for me), and I feel like I'm making a *small* impact on a food system that is so corrupt and flawed. If you want to know which movies that have changed the way I view food and health, watch the videos Food Inc and Forks Over Knives. At the very least, you'll be more mindful of what you eat, especially when you visit a fast food restaurant.
Anyways, I promised a while ago to post a recipe for amazing corn muffins, so I'll do that next time, along with the story about me getting healthy and physically fit. I think I just used that phrase because I heard that song on Madagascar, "I like to move it move it". Until then.. I'll see you later.
A working mom's musings on nutrition, beauty, and life. Nothing too important.
Monday, April 9, 2012
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Conceived and designed the experiments: FF Brockschmidt, AK Kiefer, H Stefansson, DR Nyholt, D Waterworth, JY Tung, F Geller, AM Hillmer, V Bataille, GW Montgomery, N Eriksson, AC Heath, P Sulem, TD Spector, NG Martin, LA Kiemeney, V Moorser, K Stefansson, DA Hinds, MM Nöthen, JB Richards. Performed the experiments: FF Brockschmidt, H Stefansson, D Glass, S Heilmann, AM Hillmer, V Bataille, AC Heath, P Sulem, LA Kiemeney, V Mooser. Analyzed the data: R Li, FF Brockschmidt, H Stefansson, DR Nyholt, K Song, SH Vermeulen, S Kanoni, D Glass, SE Medland, D Waterworth, F Geller, S Heilmann, AM Hillmer, C Herold, M den Heijer, T Becker, P Sulem, M Mangino, P Vollenweider, LA Kiemeney, DA Hinds, JB Rrichards. Contributed reagents/materials/analysis tools: FF Brockschmidt, DR Nyholt, SE Medland, S Heilmann, AM Hillmer, S Eigelshoven, S Hanneken, S Moebus, GW Montgomery, P Deloukas, N Eriksson, AC Heath, TD Spector, G Dedoussis, NG Martin, K Stefansson, MM Nöthen. Wrote the paper: R Li, FF Brockschmidt, DR Nyholt, S Heilmann, AM Hillmer, K Stefansson, DA Hinds, MM Nöthen, JB Richards. Survey development: AK Kiefer, JY Tung. Phenotype collection/data entry: M Dimitriou. Recruitment and phenotyping of cases: S Eigelshoven, S Hanneken. Study coordinator: S Moebus.
¶ These authors also contributed equally to this work.
The authors have declared that no competing interests exist.
Androgenetic alopecia (AGA) is a highly heritable condition and the most common form of hair loss in humans. Susceptibility loci have been described on the X chromosome and chromosome 20, but these loci explain a minority of its heritable variance. We conducted a large-scale meta-analysis of seven genome-wide association studies for early-onset AGA in 12,806 individuals of European ancestry. While replicating the two AGA loci on the X chromosome and chromosome 20, six novel susceptibility loci reached genome-wide significance (p = 2.62×10−9–1.01×10−12). Unexpectedly, we identified a risk allele at 17q21.31 that was recently associated with Parkinson's disease (PD) at a genome-wide significant level. We then tested the association between early-onset AGA and the risk of PD in a cross-sectional analysis of 568 PD cases and 7,664 controls. Early-onset AGA cases had significantly increased odds of subsequent PD (OR = 1.28, 95% confidence interval: 1.06–1.55, p = 8.9×10−3). Further, the AGA susceptibility alleles at the 17q21.31 locus are on the H1 haplotype, which is under negative selection in Europeans and has been linked to decreased fertility. Combining the risk alleles of six novel and two established susceptibility loci, we created a genotype risk score and tested its association with AGA in an additional sample. Individuals in the highest risk quartile of a genotype score had an approximately six-fold increased risk of early-onset AGA [odds ratio (OR) = 5.78, p = 1.4×10−88]. Our results highlight unexpected associations between early-onset AGA, Parkinson's disease, and decreased fertility, providing important insights into the pathophysiology of these conditions.
While most genome-wide association studies (GWAS) focus on the identification of susceptibility loci for a specific disease, this hypothesis-free approach also enables the identification of unexpected associations between different diseases by taking advantage of the previously published GWAS associations. Androgenetic Alopecia (AGA, also known as male pattern baldness) is the most common type of hair loss in humans. Parkinson's disease is reported to occur more commonly in men than in women; however, there are no studies investigating the link between AGA and Parkinson's disease. Here, we show that a specific genetic locus, chromosome 17q21.31, which is associated with Parkinson's disease, is also a susceptibility locus for early-onset AGA. We further investigate the association between early-onset AGA and Parkinson's disease, irrespective of genotype, directly in a large-scale web-based study. We find that men with early-onset AGA have 28% higher risk of developing Parkinson's disease. The early-onset AGA locus on chromosome 17q21.31 has also been linked to decreased fertility previously. Future studies of this locus may implicate novel biological pathways affecting these three conditions.
A main advantage of genome-wide association (GWA) studies is that their hypothesis-free scan of the genome for genes associated with common disease enables identification of novel associations between different diseases and pathways. For example, a pioneering GWA study demonstrated that susceptibility alleles for age-related macular degeneration were found in the complement pathway
Through previous GWA studies, we have identified genetic determinants of androgenetic alopecia (AGA, male-pattern baldness) that highlight the importance of the androgen pathway in this condition
AGA is the most common form of hair loss in humans, affecting 80% of men by age 80
Prostate cancer is the most frequently diagnosed cancer and ranks second as a cancer killer among men in the United States
Since previous GWA studies for AGA explained only 13.7% of the variance in this condition
The current analysis comprised 3,891 cases and 8,915 controls of European ancestry from seven independent studies: Bonn, CoLaus, TwinsUK, Nijmegen Biomedical, 23andMe, Icelandic, and an Australian population based twin study (
|Country of origin
|Study type
|Sample size
|Case-control (population based)
|582 Cases347 Controls
|Cohort (community sample)
|578 Cases547 Controls
|Cohort (population based)
|191 Cases198 Controls
|Cohort (population based)
|73 Cases132 Controls
|Cohort (population based)
|162 Cases210 Controls
|2,167 Cases1,753 Controls
|Cohort (population based)
|138 Cases5728 Controls
|219 Cases297 Controls
The sample size of the current meta-analysis (n = 12,806) was more than fourfold that of the earlier GWA studies of AGA
|Genetic Variant
|p value
|Number of GW Significant SNPs
|1.33 (1.22–1.45)
|1.31 (1.21–1.41)
|1.29 (1.20–1.38)
|1.27 (1.18–1.38)
|1.33 (1.21–1.45)
|1.28 (1.18–1.39)
|1.60 (1.49–1.72)
|2.20 (2.04–2.37)
Abbreviations: Chr., chromosome; EA, effect allele; NEA, non-effect allele; EAF, effect allele frequency; OR, odds ratio; CI, confidence interval.
-Chromosome position located in reference sequence of Genome Build 36.3.
-AGA risk increasing allele on forward strand.
-Gene harboring the SNP or nearest to the SNP.
Consistent with our previous reports
(A) Manhattan plot showing the −log10 p value of SNPs against their chromosomal positions. The genome-wide significant SNPs are green (p value<5×10−8). The points with p value <1×10−40 were truncated; the smallest p value was 2.4×10−91 at AR gene. (B–I) Regional association plots for eight loci associated with AGA. In each panel, the lead SNP is denoted in purple with its rs ID and association p value. The color of other SNPs indicates the LD with the lead SNP as red (0.8≤
Multiple SNPs in strong linkage disequilibrium (LD) (
The SNP with the smallest p value, apart from the AGA locus on chromosome 20, (rs9287638 [A]: OR = 1.31, 95% CI = 1.21–1.41,
Thus, two independent signals arose from HDACs (
Remaining novel findings include one locus on chromosome 1 which is near the genes
Regional association plots for seven loci associated with AGA are shown in
While any of the above susceptibility loci may impart a small risk, examining the combined effect of these loci in individuals harboring more than one risk allele may improve the ability to identify individuals at high risk of AGA. Using the top SNPs identified in this study from both the 6 novel loci and the 2 confirmed regions on chromosome 20p11 and
|Genotype score
|p value
|p value for Trend across all 4 quartiles
|Quartile 1
|1.00 (Reference)
|Quartile 2
|2.20 (1.87–2.59)
|Quartile 3
|3.50 (2.96–4.13)
|Quartile 4
|5.78 (4.86–6.87)
Abbreviations: OR, odds ratio; CI, confidence interval.
-The top SNPs from each genome-wide significant loci as shown in
Reasoning that
We identified that the 17q21.31 locus overlaps with a widely replicated locus that is strongly associated with Parkinson's disease
To explore this unexpected relationship between Parkinson's disease and early-onset AGA we next sought to understand whether AGA itself was a risk factor for Parkinson's disease. From among a superset of the early-onset AGA cases and controls using the same definition for AGA as in the meta-analysis, we identified 568 self-reported physician diagnosed Parkinson's disease cases, and 7,664 population controls
To investigate whether the shared genetic association at 17q21.31 explained the association between Parkinson's disease and AGA, we evaluated a regression model with an additional term for an individual's genotype at rs12185268, which is the variant in this region most strongly associated with Parkinson's disease in the 23andMe study. The OR for association with early-onset AGA and its significance were essentially unchanged (OR = 1.96, 95% CI = 1.32–2.90, p = 6.0×10−4). In the individuals in the age 70 or higher group, we also tested the association between Parkinson's disease and AGA stratified by rs12185268 genotypes. The AG and GG genotypes are pooled due to the small proportion of GG homozygotes. There is no essential difference between the odds ratios for individuals with rs12185268 AA genotypes (OR = 1.93, 95% CI = 1.16–3.21, p = 8.7×10−3) and AG+GG genotypes (OR = 2.07, 95% CI = 1.09–3.93, p = 2.2×10−2), indicating that rs12185268 does not modify the association between Parkinson's disease and early-onset AGA.
We next looked for evidence that any other loci associated with Parkinson's disease were also associated with early-onset AGA, or vice versa. We identified the lead SNPs from 27 loci with p<1.0×10−5 for association with AGA, and 31 loci with p<1.0×10−5 for association with Parkinson's disease. We tested the AGA loci for association with Parkinson's disease, and the Parkinson's disease loci for association with AGA. The 17q21.31 locus was the only locus demonstrating convincing evidence for association across both phenotypes (
Parkinson's disease is the second most common neurodegenerative disorder with a prevalence of one percent in individuals that are over 60 years old
Our data specifically identify genetic variation in the 17q21.31 region as shared genetic risk factors for these two conditions. To date, only drug-induced hair loss has been described in patients having Parkinson's disease after use of dopamine agonist
Furthermore, the 17q21.31 locus harbors an inversion polymorphism that has previously been described to be under negative selection pressure and has been demonstrated to be associated with decreased fertility in women
Even though the definition of hair loss and the method of sampling differed between the eight study groups, the associations of five genome-wide significant loci were essentially identical in fixed- and random-effects analysis, suggesting that our results are unlikely to be influenced by heterogeneity.
We are aware that some other diseases, including progressive supranuclear palsy, corticobasal degeneration, frontotemporal dementia and Pick disease are also strongly associated with 17q21.31 region
Since 17q21.31 locus has been recognized as a risk factor for Parkinson's disease, it is plausible that an individual's status of Parkinson's disease may have an effect on the association between 17q21.31 locus and early-onset AGA. We undertook an association analysis conditioned on Parkinson's disease in 8,232 individuals for whom both phenotype are available and confirmed that status of Parkinson's disease does not affect the strength of association between AGA and rs12185268, the top variant at 17q21.31 locus in this sample (unconditioned: OR = 0.76, 95% CI = 0.70–0.82, p = 7.9×10−13; conditioned: OR = 0.76, 95% CI = 0.70–0.82, p = 7.9×10−13). This result was verified within strata of Parkinson's disease: OR is 0.69 in the cases (95% CI = 0.51–0.94, p = 1.8×10−2) and 0.76 for individuals without Parkinson's disease (95% CI = 0.71–0.83, p = 1.1×10−11). Further, the relationship between the 17q21.31 locus and Parkinson's disease was not affected by conditioning on AGA status although the association with rs12185268 was not significant (unconditioned: OR = 0.99, 95% CI = 0.84–1.15, p = 0.86; conditioned: OR = 1.00, 95% CI = 0.86–1.17, p = 0.97).
Our data demonstrated several aspects of the relationship between AGA and Parkinson's disease: First, variants at 17q21.31 locus including the
The identification of the new associations in this report was driven primarily by augmented power arising from the expanded sample size, which was more than fourfold that of previous GWA analyses
In conclusion, our findings provide fresh insights into the pathogenesis of early-onset AGA. As these newly identified susceptibility loci are also implicated in Parkinson's disease, prostate cancer and fertility, our results highlight the importance of hypothesis-free genetic studies, which allow unexpected genetic relationships between conditions to uncover shared etiologies.
All seven studies were approved by institutional ethics review committees at the relevant organizations, and written informed consent was provided by all participating individuals.
All the participants for this genome-wide meta-analysis were drawn from seven studies: Bonn (582 cases and 347 controls), CoLasu (578 cases and 547 controls), TwinsUK cohort (162 cases and 210 controls), Nigmegen Biomedical Study (73 cases and 132 controls), 23andMe (2,167 cases and 1,753 controls), Iceland (191 cases and 198 controls), Australian population based twin study (138 unrelated cases and 5728 unrelated controls). A detailed description of all these studies and phenotype definitions used in current study is provided in
The genotyping platforms, imputation methods and genome wide association methods used in participant studies are provided in
We carried out a meta-analysis under both fixed- and random-effects models using the inverse-variance method to combine results from each study using an additive genetic model, while correcting for the genomic inflation factor for each study and the overall meta-analysis. To implement this strategy GWAMA software was used for SNPs on autosomes
Genome-wide suggestive SNPs (5×10−8<p<5×10−6, n = 397) that were imputable using the MetaboChip platform were followed-up in an expanded meta-analysis including the THISEAS study
To understand whether the identified SNPs are in close proximity to genes that show differential expression in hair follicles, we performed tissue expression analysis. In brief, total RNA extracted from human hair follicles, skin from temple, scalp, and whole blood were used for array-based gene expression analysis. The differential expression of genes in these tissues was determined by the average signal of identical probes and detection p values (which is significant, if a gene is reliably expressed). Further details are provided in
In genotype risk score analysis, the association between a genotype risk score based on the weighted number of susceptibility alleles and AGA status was determined. Six novel susceptibility loci, chromosome 20p11 locus and
To detect the potential modification effect of
In order to better understand whether the identified risk loci from the meta-analysis were associated with common diseases, we searched the AGA susceptibility loci using the GWAS Integrator embedded in HuGE Navigator website
To examine the relationship between Parkinson's disease and AGA, we performed a logistic regression of Parkinson's disease status against AGA status, evaluating significance of the AGA term by analysis of deviance using a likelihood ratio test. To control for confounding factors, we included age, age2, and the top five principal components derived from genotype data as covariates.
Quantile–quantile plot of Meta-Analytic Results. (Genomic Control was applied to each individual cohort prior to meta-analysis and the overall results).
Quantile–quantile plot of Meta-Analytic Results after removing SNPs of AGA locus on chromosome 20 and SNPs of AR locus on chromosome X. (Genomic Control was applied to each individual cohort prior to meta-analysis and the overall results).
Forest Plots of the Lead SNP from Genome-Wide Significant Loci.
Genotyping, imputation and statistical analysis used in the GWA studies.
Genome-Wide Significant SNPs in fixed-effect model (p<5×10−8).
Average Expression Signal for All Genes Shown in
Summary result for the top SNPs from the genome-wide significant loci using random effect models.
Interaction results between top SNPs of
Association test results for AGA, at Parkinson's disease loci.
Association test results for Parkinson's disease, at AGA loci.
Description of participant studies and phenotype definition. Methods of tissue expression analysis are also described.
We thank all participants for their participation in this study. We also thank Dixie Statham, Ann Eldridge, Marlene Grace, and Kerrie McAloney (sample collection); Anjali Henders, Megan Campbell, Lisa Bowdler, and Steven Crooks (sample and DNA processing); Scott Gordon, David Smyth, Harry Beeby, and Daniel Park (IT support). We thank Dr. Roland Kruse for his contributions to the German AGA study and Dr. Michael Alexander for help with the expression experiments.
The URLs for data presented in this paper are as follows:
HuGE Navigator website,
The GWAMA program,
The IMPUTE program,
The International HapMap Project,
The MaCH program,


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Patriots Colony at Williamsburg was an elegant place, and the staff is very attentive. It has a fairly large entry fee. It's in a hundreds of thousands of dollars. I have eaten there several times, and the food is very good. They offer 2 meals a day, and the dining area is very upscale. There were many activities, and they had card rooms, libraries, and many planned events. I think it's an outstanding place. They have a nursing home and rehabilitation.
Patriots Colony at Williamsburg
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I visited this facility
October 18, 2012
I am a friend or relative of a resident
I visited Patriot's Colony on several occasions. I have visited my grandparents for holiday dinners, birthdays, and anytime I'm passing through and have the time to stop. They rave about the community here. Whether it's weekly card games, gardening, or golfing, residents find ways to stay active. I particularly enjoy the mixed community - they have retirement condos, assisted living apartments, and a nursing home. I think having all three in one place makes the community more vibrant and makes the transition to more intensive care easier on residents and families.Additionally, the staff is extremely friendly and accommodating. They know more of the residents by name and are excited to meet member of the resident's families. I have never encountered poor service there in my 5 total visits. They manage to balance healthy options for those with strict dietary needs with high quality standard fare you'd expect to find in an average restaurant. They also have a rotating menu, which is nice for the residents.
About Patriots Colony at Williamsburg
Patriots Colony at Williamsburg is a continuing care retirement community in Williamsburg, VA that offers housing options for currently healthy people who want to secure their healthcare plan throughout the aging process. Contact Patriots Colony at Williamsburg for more details on CCRC housing and rates.
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For Scott-Robertson there are 4 on Yasni with different names.
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Google's highly anticipated, and heavily leaked, smartphones are now official. They're high-end, strong on software, and effectively replace the Nexus series as Google's flagship smartphone lineup. Without further ado, here are the Pixel and Pixel XL.
It seems like all the Google Pixel leaks we've seen in the past week were indeed legit. If you've been following our coverage, you would've already had a clear look at the design and specifications of the internet giant's latest smartphones.
As expected, the only difference between the two handsets is size: The Pixel has a 5.2-inch AMOLED screen with a Full HD resolution, while the 5.5-inch Pixel XL has a noticeably better Quad HD AMOLED panel. The difference in measurements extends to the batteries, wherein the Pixel and Pixel XL have 2770mAh and 3450mAh capacities, respectively.
The lack of major differences is a big deal, because you aren't forced to choose a larger phone just for its beefed-up features. This is something Google failed at with the Nexus 6P and 5X; the former was equipped with flagship-level specs, but the latter had the pocketable size nearly everyone wanted at the time.
Whether you go big or small, you're treated to a metal unibody with a glass coating around the fingerprint scanner mounted at the back. With a thickness of 7.3mm for both handsets, they won't win any style awards, but the inclusion of a 3.5mm audio jack will delight a lot of traditional audiophiles.
The shared internals include a powerful Qualcomm Snapdragon 821 processor, 4GB of memory, storage options of 32GB and 128GB, and fast charging through a USB Type-C port, but what really stands out is the camera. Having a 12.3-megapixel main shooter and 8-megapixel selfie camera with no optical image stabilization whatsoever may not seem special, but the real-world performance says otherwise.
If you recall our recent article on the iPhone 7's DxOMark rating, you'd know that the Samsung Galaxy S7 Edge's camera is the benchmark's king with 88 points. Well, with the release of the new Google phones, the Galaxy has been unseated by the Pixels' 89 points — the highest ever recorded in DxOMark's mobile phone database. Impressive!
In case you're wondering, the phones are manufactured by HTC, but Google is keeping this piece of information under the rug. The company wants Pixel to feel like a fully integrated Google product. To do that, the brand's new virtual assistant is at the forefront of the Pixel phones.
Along with Android 7.1 Nougat, the Pixel phones are the first to come with Google Assistant, which is the company's answer to Apple's Siri and Microsoft's Cortana. Google spent a ton of time explaining all the core functions at the event, but in a nutshell, the virtual assistant is really efficient at catering to your personal requests. The more you use it, the smarter it gets.
With the improved artificial intelligence, you can search through photos with ease and listen to your favorite music on the fly, all done by voice command. Google Assistant is pretty much the replacement of Google Now, the now obsolete assistant of every other Android device.
The color options are quite humorous; you have Quite Black, Very Silver, and Really Blue. What isn't funny, however, is the pricing. Prices begin at $649 for the smaller Pixel — as much as you'd spend on a brand-new iPhone 7. The 128GB variant costs $749, while the larger Pixel XL goes for either $769 or $869 for the 32GB and 128GB storage options, respectively.
On the bright side, the phones come with unlimited cloud storage on Google Photos at original quality and full resolution. That's great value, and might make the 32GB storage option enough if you have a reliable internet connection on hand.
You can pre-order as early as today if you live in the US, Canada, UK, Australia, or Germany. Fans in India will have to wait until October 13 to begin ordering.


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As an integral part of the core team, you will participate in product and solution brainstorming sessions and be required to take up some feasibility research on specific subjects. This could also include interfacing with external partners and associations in specific projects.
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716 Pearl Street, Jacksonville, FL 32202Request info Add to list
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Lot of 105 X 105, less corner of Union St. and Pearl rounded by Jacksonville Expressway Authority. Union Street with 3 traffic lanes and one turn lane one way east bound with 26,000 +/- AADT. 0.3 mile east of I-95 interchange. Site above streets with curb cut to Union St. The rest of the block is vacant land.
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Basic Hole Making. Machine Planning for Hole Operations. Not all holes are equal! Some holes are rough holes Some holes require tight tolerances Some holes are compound features Consider hole attributes when selecting hole making operations. Attribute 1: Basic Shape of Hole.
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Attention All Sub Cable World Subscribers!
This Friday will be the last New Feed post until Monday, November 27th 2017.
Come back on the 27th and check out the NEW and improved Sub Cable World.
|Permanent Reservoir Monitoring (PRM)
|Submarine Cable NewsFeed - Offshore Communications
|Friday, 20 March 2015 10:06
Permanent Reservoir Monitoring (PRM) is a technique using permanently installed seismic cables to extend the life of an offshore oil or gas field. Like many new concepts, PRM has been slow to take off, but is starting to make waves in the offshore world.
Global Marine Systems Ltd recently presented at the Third EAGE (European Association of Geoscientists and Engineers) Workshop on Permanent Reservoir Monitoring and has made its presentation, entitled "Permanent Reservoir Monitoring (PRM) System Installation: The Installers Perspective," available on its website at http://www.globalmarinesystems.com/uploads/images/news/prm-an-installers-perspective.pdf.
An older article from Statoil describes PRM from a producer's perspective. This can be viewed at http://www.statoil.com/en/TechnologyInnovation/OptimizingReservoirRecovery/Pages/2012_13Dec_Permanent_Reservoir_monitoring.aspx.


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West Tyrone MLA Michaela Boyle says if Quantum Hosiery in Strabane closes it will mark another blow to the textile industry in the North West.
She claimed Quantum - based in the old 'Adria' factory - was set to re-locate jobs to England.
"This is another massive blow for Strabane. I am absolutely devastated for the workers and their families.
"I know some of the workers personally and I am truly saddened by the news. It appears as though this is the final nail in the coffin for the old Adria site as the last workers from Adria go.
"It is now important that the needs of the workers are paramount as they face an uncertain future."
She claims to have written to Quantum in conjunction with Pat Doherty MP asking them to re-think.
"We have also requested a meeting with the head of InvestNI to receive an update on the Strabane business park which remains empty.
"It is vital that we start to benefit from this site by infrastructure being put in place through inward investment, business expansion and most crucially the creation of new jobs."


text: Transas Marine Pacific was invited to present its state-of-the-art Crisis Management System – PISCES - at one of Malaysia's most important professional forums. A Marine Environmental Conservation Course under the auspices of the Malaysian Technical Co-operation Program was convened at country's premier maritime education and training institution - Akademi Laut Malaysia (ALAM) - from June 17 to 30, 2007. Twenty delegates from the Yemen, Bangladesh, Sri Lanka, Tonga, Timor & the Philippines represented a wide cross-section of government bodies. Coastguard personnel, biologists, researchers and ecological managers attended the event. Capt. Sundeep R Sequeira from Transas Marine Pacific led the presentation devoted to training in emergency situations using the example of Transas CMS. The Crisis Management System takes advantage of current technologies in networked computer systems and wireless communications to enable the rapid exchange of data and to reduce the workload of those persons tasked with archiving, retrieving and displaying information. Components are developed to support all areas of responsibility including overall command and control, decision-making, operations, planning, logistical support, and financial/administrative functions. A video demonstrating a joint oil spill response exercise between Russia, Estonia & Finland (held in 2006) was shown to provide a better understanding of the functionality & operability of the system.


text: Rodneys Transport Service Pty Ltd (RTS) is a locally owned and operated private transport and distribution business. Established in 1992, our company operates from its primary site - 50acres within the Bomen Industrial Estate, north of Wagga Wagga and is the largest privately owned Line Haul Operations Company within the Riverina. In addition the company has a secondary storage site (150 acres) within the estate with a current palletised freight capacity in excess of 100,000 pallets with customers being able to select palletised storage options ranging from 5,000 – 20,000 pallets.


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Sony KV32LS35
This Sony WEGA TV incorporates 16: 9 enhanced mode, Virtual Dolby with Hi-Fi Stereo 2 x 7 Watt/Subwoofer 10 Watt. The Sony 32LS35 is another flat-scre...
4 reviews from the community
Review of "Sony KV32LS35"
"The Daddy of Televisions"
Just one night sitting in front of this TV will convince you that you've bought one of the technically best sets in its class.A colleague of mine who is a TV engineer recommended Sony Wega Trinitron sets as being the very best and he must have seen a few.
In the past I used to swap computer monitors and the Sony's were always the best, But they always used to have "fly lines" - 2 horizontal lines caused by the shadow of 2 parallel wires inside the tube. Something to do with an aperture grill tube but Im not tekky enough to know how or why just they were the best pictures, slightly spoiled by these lines.
Thankfully these are a thing of the past.
Naturally it has fast text and the ability to swap between display sizes Smart / Zoom / 4:3 / Wide / 14:9 mode.
Virtual Dolby surround sound is standard, however I have added a surround sound system and 5:1 speakers for true surround sound. If your going to have home cinema you need the sound to go with it.
Up to 100 channels can be stored in the sets memory.
Dual Scart input at the rear. AV input thru an invisible flap which opens up when needed at the side of the set.Headphone socket. S-video socket (for connecting your video camera)
Rear audio out socket so you can connect your own sound equipment.Smartlink socket - this is specific to Sony kit for connecting Sony DVD's,Video's etc.
Long silver remote control - looks classy.In summary. If you or your family watch alot of TV then when you watch a high quality DVD on this set with surround sound, you just cant get any better.
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Kay26 published 26/07/2004Well written and informative review :-) Kay
cybersplat published 15/06/2004Nice review, I wish I could afford a television like that!
benraiben published 14/06/2004Nice review! Welcome to Ciao! Ben
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Product Information : Sony KV32LS35
Manufacturer's product descriptionThis Sony WEGA TV incorporates 16: 9 enhanced mode, Virtual Dolby with Hi-Fi Stereo 2 x 7 Watt/Subwoofer 10 Watt. The Sony 32LS35 is another flat-screen television in the illustrious Wega line, which offers stylish design. On-screen displays make it easy to adjust more picture, sound, and convenience features. Front A/V input is also included to attach a camcorder or video game console. Convenience features include a sleep timer, Fastext with 10-page memory, Auto Labeling/Auto Sorting. Turn on the tube and enjoy the brilliant sights and sounds the Sony WEGA brings home.
Product Details
Manufacturer: Sony
Integrated VCD Player: No
HDTV Norm: No
Picture Scan: Single Scan
Sound System: Stereo
Digital Tuner: No
Screen Size in Inches: 32
Built-in Sat-Tuner: No
Real Dolby: No
Screen Format: 16:9
Videotext/Teletext: YES
Screen Size in cm: 76, 82
Built-In Modem: No
Frequency: 50 Hertz
Realflat: with Real Flat Screen
DVD Player / Recorder: No
DVB-T: No
Picture in Picture (PIP): No
Frequency in Hz: 50
Slim Tube: No
Listed on Ciao since: 13/09/2002


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You are the law and only you possess the power to stop the evil vehicles! Run the bad guys off the ramps to restore peace on the streets. Each vehicle on your disposal has its own strengths and special abilities - use them wisely.
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