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Production images have been released of Willemijn Verkaik and Savannah Stevenson as Elphaba and Glinda respectively, who join the cast of Wicked tonight (18 November) at the Apollo Victoria Theatre
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18 Nov 2013
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Best 1st chapter I've ever read!
Published by teacherayala in the blog teacherayala's blog. Views: 113
In my house, I have books overflowing onto various desks, cubbies, drawers, bookshelves and closets. I just ran across one that I didn't recognize. I must have bought it in a patio sale here in Panama from a family moving away.
It's entitled The Angel's Game by Carlos Ruiz Zafon, and I have no real idea how it will turn out or what the novel is really all about. However, it has the best 1st chapter I've ever read. If I had been an editor, I would have published this book hands-down.
Hopefully I'm not violating any copyright laws by sharing with you the first paragraph and a few juicy tidbits. I have a feeling it will make many of you go out running to your local bookstore to find this author's book.
"A writer never forgets the first time he accepted a few coins or a word of praise in exchange for a story. He will never forget the sweet poison of vanity in his blood and the belief that, if he succeeds in not letting anyone discover his lack of talent, the dream of literature will provide him with a roof over his head, a hot meal at the end of the day, and what he covets the most: his name printed on a miserable piece of paper that surely will outlive him. A writer is condemned to remember that moment, because from then on he is doomed and his soul has a price."
The narrator goes on to describe his first editor who gave him his first break as having a "bushy moustache" and having "subscribed to the theory that the liberal use of adverbs and adjectives was the mark of a pervert or someone with a vitamin deficiency."
His advice to the narrator? "You have more zeal than good taste, Martin. The disease afflicting you has a name, and that is Grand Guignol: it does to drama what syphilis does to your privates. Getting it might be pleasurable, but from then on it's all downhill."
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subset: commoncrawl


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Good Vibrations: Smart Access to Homes and Cars Using Fingers Rutgers engineers create VibWrite, a finger vibration-based security system By Todd B. Bates October 29, 2017 "Good, good, good, good vibrations" goes the catchy...
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ECE News
In an effort to highlight the research in our department, allow students to network with their peers, help them select an advisor, and also motivate our undergrad students to get involved in research, ECE Research Day was held on Tuesday, November 7 from 3pm-5pm in EE building hallway. Both...
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Steve Nelson: Hillary Clinton's moral responsibility
WASHINGTON, MA. >> One person has the power to make Donald Trump the next president of the United States. Or not. Her name is Hillary Clinton.
This election is more than the usual quadrennial contest about which party will win the White House. Trump is a danger to the Republic. Now that she is the presumptive nominee of the Democratic Party, Clinton bears a moral responsibility to make sure that he is not elected.
This is, to say the least, an unusual election year. A reality TV star and real estate developer, with a string of business bankruptcies and failed marriages but no background in government, emerged from a field of 17 candidates, including senators and governors, to capture the Republican nomination through a campaign based on divisiveness, innuendo and hostility.
At the same time, a 74-year old socialist virtually unknown a year ago led a youth crusade financed by small donors and forced an opponent with impressive credentials, powerful connections and unequalled name recognition to fight through a long primary season before she could secure the Democratic nomination which once seemed like hers for the taking.
No playing it safe
Trump and Clinton have unprecedented unfavorability ratings for major party candidates, and are neck-and-neck in recent polls. With five months until Election Day, the outcome is unpredictable. Clinton cannot be assured of victory by following the game plan which got her this far. Playing it safe is too big a risk.
Instead of being controlling and closed, she needs to open up in ways she has not been comfortable with until now. That means taking full and unconditional responsibility for her use of private e-mail while secretary of state, not making half-hearted apologies only after public pressure forced her to.
The report by the inspector general of the State Department said she did not ask for nor would she have received permission to use a private e-mail server. It also noted that she had declined to be interviewed during the investigation, and likewise had instructed her staff not to either.
While she still faces possible indictment by the Justice Department for mishandling of secret information, it's more likely she'll just get a slap on the wrist. But she can't treat a decision not to prosecute her as exoneration, and dismiss it without accepting responsibility.
She also needs to come clean on what she said in those infamous three speeches to Goldman Sachs for $675,000 each. The executives who were there never go anywhere without their phones. Someone may well have a recording and leak it when it can do maximum damage to her campaign — an October surprise. She needs to put this behind her now.
These two issues may seem like they were more relevant during the primary, but Trump will go after her any way he can. The significant danger she faces is that her tendency to stonewall will turn off voters who won't vote for Trump, but might vote for a third-party candidate from the Libertarian or Green Party, or just stay home. In a tight race, even a small defection of left-leaning younger voters Clinton should be able to count on could throw the election to Trump. She needs the young supporters of Bernie Sanders now, and the Democratic Party needs them for its future.
Hillary Clinton stands on the threshold of becoming the first woman president of the United States. But at the same time, we face the risk of Trump putting his name on the prime real estate at 1600 Pennsylvania Avenue.
Talk to us personally
This extraordinary fork in the road of our national destiny calls for an extraordinary response from Clinton, not just politics as usual. It is her moral responsibility. She should go on national television to give the speech of her life, and possibly ours. To address our lingering concerns about her trustworthiness and her commitment to progressive issues. To reveal more intimately the person who would become our president.
Yes, she'll be giving her acceptance speech at the Democratic Convention, amid the usual hoopla. That's a political performance. But what she must do before then is to talk to us personally, to reassure us, to satisfy our doubts. Then we'll be cheering along with the crowds on the convention floor.
Steve Nelson is an occasional Eagle contributor.
If you'd like to leave a comment (or a tip or a question) about this story with the editors, please email us. We also welcome letters to the editor for publication; you can do that by filling out our letters form and submitting it to the newsroom.


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The Sheriff's Office reported the following:
9:42 a.m., Tuolumne - A woman said someone stole a 50-foot black garden hose from her residence on the 20100 block of Chapel Drive.
10:20 a.m., Columbia - Someone spray painted on the walls of a newly remodeled room at motel on the 22600 block of Broadway Street.
3:52 p.m., Mi-Wuk Village - A woman said someone burglarized her deceased parents' residence on the 21100 block of Wallim Court.
3:10 a.m., Sonora area - Someone saw a U-Haul van parked on Big Hill Road near Sierra Glen Apple Ranch. Two men were moving things out of the van to the side of the road and started running away when the caller approached.
6:13 a.m., Columbia - A man on the 11000 block of State Street said someone came into his apartment while he was sleeping and took his video games.
The Sonora Police Department reported the following:
7:48 a.m., controlled substances - Drug paraphernalia was found on South Stewart Street. Sonora police seized the paraphernalia and booked it for destruction.
8:20 a.m., vandalism - Someone said a vacant building on the 700 block of Mono Way was shot with paint balls.
7:01 p.m., hazardous situation - Someone put a box of nails in the roadway near the Red Church on North Washington Street.
The Sheriff's Office reported the following:
8:55 a.m., Angels Camp - Someone said a theft occurred on Red Hill Road.
9:15 a.m., West Point - A burglary occurred on Highway 26.
6:19 p.m., San Andreas - A man on Calaveritas Road said someone stole a $1,000 set of golf clubs from his porch over the weekend.


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As one of the leading and well renowned language schools Vancouver, International House (IH) offers German classes Vancouver that focus on developing your German language conversational and writing skills in a very practical and communicative yet innovative manner. Our German classes are taught by experienced German language instructors who focus on integrating the primary skills of speaking, listening, reading and writing. At IH Vancouver (as is with all the International House's network of language schools worldwide), our aim is to provide highest quality in language training and excellent learning facilities to language learners.
International House Vancouver offers both individual and group classes for German and our German classes program is very flexible indeed and provides you the facility to create the study plan according to your personal timetable. Come join us at IH Vancouver for learning while having fun.
For more details about how to register with IH Vancouver, please go to Registration page.
International House is closed on
school and public holiday.


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You are here
Continuing Professional Development
Message from the Director:
Thank you for visiting the webpage for Continuing Professional Development (CPD) at The Ohio State University College of Pharmacy. We welcome you to explore our latest news, resources, and upcoming events. Please note that our website is under construction and we will be adding more information regularly, so we appreciate your patience during the process and encourage you to check back often.
Changes in the health care system as a result of the 2010 Patient Protection and Affordable Care Act will bring many shifts in the education, training and practice environments for current and future pharmacists. Emerging models of care bring opportunity to advance pharmacy practice. The challenging job market for pharmacists necessitates ongoing continuing professional development for graduates to be prepared to practice in those markets. Our group serves to meet those needs as well as create new practice opportunities to move the profession of pharmacy forward. We are excited about the future of pharmacy and serve you as the leading expert in fostering the innovation and entrepreneurship to transform pharmacy practice!
Bella Mehta, PharmD, FAPhA
Our goals are to:
- Develop and deliver continuing professional development with a contemporary focus that offers real world experiences with business and industry leaders and advances the pharmacy profession locally and globally
- Cultivate programs that prepare current and future pharmacists to practice at the top of their license
- Collaborate with internal and external university partners to drive practice transformation and improve patient care
- Partner with internal and external university partners to conduct and disseminate practice based research
- Enhance public education about the value and role of the pharmacist as part of a health team
- Foster development and dissemination of best practice models of pharmacist-provided care


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Workshop on Main Results of Research Program on Strengthening Vietnamese Families in the Period 2011-2020 (May 9, 2013)
Within the framework of the ministerial-leveled research program on Strengthening Vietnamese Families for the period 2011-2020 conducted by the Institute for Family and Gender Studies in 2011-2012, on 24-25 September 2012, in Ha Noi, the Institute for Family and Gender Studies held a workshop on the main results of the research program. Researchers of the IFGS and some scholars from other institutions were attended the workshop.
The Research Program on Strengthening Vietnamese Families for the Period 2011-2020 includes six studies covering the issues on the organising family life of migrants, the values of child in Vietnamese families, the marital relationships and intergenerational relationships including the relationships between parents and adolescent children, between the elderly members of family and their adult children and grandchildren.
The workshop aimed at several objectives. First, it placed the forum for researchers to share ideas and research results and learn from one another. Second, it is to review and look back comprehensively the results of research projects of the Program at the final stage of research process. By doing so, the workshop is the great opportunity for the Institute to get the contributive ideas for the completion of the Program Report which is anticipated to inform evidence-based policy implications in the context of global integration and social changes in Vietnam in the period 2011-2020. Third, the workshop offers young and mid-career researchers an opportunity to learn methodologies, research approaches, analytical skills of qualitative and quantitative data, writing skills and presentation skills through their interaction in the workshop. It is also part of the capacity building activities within the framework of the Institute's human resource development strategy.
The workshop is divided into two parts. The first part focuses on three issues, including the theoretical approaches of family relationship research, the emerging issues of child values in Vietnamese families, and the options of migrants in organizing their family life and making migration decisions. In the current context of Vietnam, the theories of role, structural functionalism, conflict, and gender studies are mostly applied in examining and analyzing family relationships. Family relationships are closely associated with several factors relating to individuals, family environment, kinship, community and society. The close relationships between economic resources and cultural norms, the active participation of women in labour market, the improvements of women's education attainment and thus in their economic independence are much linked with the change in marital relationships. Family relationships also are influenced by the intensively tradition factors including gender stereotypes, communication, mutual entertainment activities, affections, sexuality, intergenerational interaction to modernity-related factors like individual privacy, problem-solving skills and state-related factors such as family policies, legal system, and family-friendly programs. The study on child values is considered a need in the currently transitional Vietnam. It is assumed that social changes and rapid development and integration of the country have brought about changes in people's attitudes towards having a child, son preference and the meaning of a child. The preliminary analysis indicates that several issues, including the economic meaning of child(ren), the psychological and mental meaning of child(ren), the costs of having child(ren) need further study and explain in the new context. Migration is universally phenomenon in the globalization and integration age and also a representation of modernization and social change. Migration has changed the family structure now that families have just a parent at home or both parents are away from home. Therefore, migrants face several challenges to organize their family life and maintain the conventional family functions. Men and women consider differently factors before making decision of migrating in which the benefit of children and the household's income generation are the most considered.
The second part discusses three family relationships (husband-wife; parents and adolescent children; and the elderly and other family members). The presentations in this part provide the evidence of changes in these family relationships in the current context and point out the perspectives of relationships need more researching and intervening in order to build strong families in Vietnam. The study on husband-wife relationships points out significant changes which are closely associated with the changes in women's roles in family and society. Traditional stereotypes which used to control husband-wife relationships seem now out-of-fashion since women have actively participated in labour force. Novel practices of communication and interaction between husband and wife are observed while a large number of people are still reluctant to accept them. These create conflicts between husband and wife. Research results suggest that the country's rapid economic development has brought about great opportunities for the development of adolescents in the meanwhile it has offered window of challenges for both parents and adolescent children in harmonise the relationship between parents and adolescent children in different ways. The third family relationship discussed in the workshop is the relationship between the elderly and children/grandchildren. It is observed that the most preferable living arrangement of elderly in Vietnam is living separately and close to adult children's house that on one hand mitigate the conflicts amongst generations while the elderly still can easily get support and care from their children. The data analysis also implies that modernisation-related factors have transformed the relationship between the elderly and other family members.
Given its objectives, the workshop was successful in the way that it did open forum for researchers to discuss, exchange and learn. The presenters received a lot of comments and contributive ideas for their research. The discussion also opens windows of research areas for themes and invites further research for the Institute.
ReporterBack to list


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Instead I looked at the weekly quilting linkups. Surely you've had this experience: you click on one thumbnail photo in a blog linkup and you meet another quiltmaker. She links to her quilting blog pals and a half hour later you've made six comments and gotten three new design ideas.
|Design (c) Tisha Nagel
Tisha has divided the quilt-along into four weeks -- choosing fabrics, cutting fabrics, piecing blocks, assembling the top. I don't want to take that long. I pulled a stack of black/white FQs and some brights.
I made a few blocks in the stated size (6" fin.) and put them on the design wall. Hmmm. What if I made a smaller size? What if I made a larger size?
I made some 3" and 9" blocks.
Here is the work-in-progress. I'm aiming for 54" x 60". I need to balance the colors and the block sizes. I'm having fun!
Thanks for your kind words, prayers, and healing thoughts for my husband. Last Tuesday he was released from the hospital to rehab where he is not happy. I hope he can be released this week to continue as an outpatient.
I'm joining quiltmakers on
Oh Scrap
Monday Making
Main Crush Monday
Design Wall Monday


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Accessible Treatment
To radically expand treatment options for people who use substances, The Center has expanded its services beyond our own offices. Since 2000, we have provided therapy and medication services to the clients and participants of many community-based organizations.
The people we work with in our Community Services are extremely low income, homeless or marginally housed, universally traumatized, and suffering from other mental illnesses. They use drugs to cope with these problems and a myriad of stressful situations each day.
We like to say that clients "vote with their feet". People meet us on the street, in the park or in a drop-in center. If they feel comfortable, they seek us out. Or they check out our many drop-in groups around San Francisco. If they feel like they can share without being judged, they come back. In this way, we engage and work with up 1000 people a year.
The Center is, without a doubt, the lowest-threshold mental health and substance abuse treatment service in the San Francisco Bay Area, and likely in the country. And our model of community service is studied by many who also believe that a radical change is necessary in how we treat people's suffering.
Partnerships in Vulnerable Communities
We partner with five community-based organizations – Hospitality House, the Homeless Youth Alliance, Office-based Opiate Programs, and San Mateo County HIV/AIDS Programs to bring our services to the communities where marginalized people live. At these programs, we offer:
- Outreach on the streets and in Golden Gate Park
- "Sidewalk therapy" – for people who are too afraid to come into an office
- Crisis intervention & de-escalation
- Walk-in and appointment-based therapy
- Medication evaluation and management on a walk-in basis
- 12 drop-in groups and one drumming circle per week
In addition to client services, we offer ongoing staff support and consultation at all of these agencies and dozens more, including our newest project to be available for emergency consultation to staff of At the Crossroads, a night outreach team that works with youth on the streets of the Tenderloin and the Mission.


text: I saw a glimpse of this hotel this morning while looking through Pinterest this morning. I just had to see more. Stay is a new hotel concept located close by the center of Copenhagen. The design is Scandinavian minimalism at it's best were quality over quantity is clearly the aim. Next time I'm in Copenhagen, I'm defiantly checking in to Stay.


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The European Union said yesterday its antitrust regulators might need several weeks to decide whether to slap Microsoft with huge fines...
BRUSSELS, Belgium — The European Union said yesterday its antitrust regulators might need several weeks to decide whether to slap Microsoft with huge fines once a deadline of midnight tonight expires for the software maker to comply with a landmark ruling.
"This is highly complicated stuff, and therefore we will see what they come up with and analyze it carefully," said Jonathan Todd, spokesman for the European Commission, the EU's regulatory arm. "Once the deadline has expired, it will take several weeks to analyze what's on the table," Todd said.
Both sides worked over the weekend to reach a compromise. The talks have centered on pricing and royalties that can be charged to allow software competitors access to Microsoft's Windows source code so they can better dovetail their products with the platform.
"We continue to work hard with the EU commission toward an agreement on compliance," Microsoft spokesman Tom Brookes said.
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The EU can fine Microsoft up to 5 percent of its daily global sales for each day a decision is not applied to the EU's satisfaction.
After the analysis, the commission "will either conclude that it is sufficient or not, in which case we will set in motion the procedure for fining them," Todd said.
In March 2004, EU antitrust regulators fined Microsoft a record $624 million when they ruled the company abusively wielded its Windows software domination to lock competitors out of the market.
The orders of the European Commission require Microsoft to share under certain conditions its Windows server code with rivals to make the industry more competitive in the European marketplace.
Last month, the regulators were still not convinced the Windows version the company was forced to produce without Media Player was technically up to standard.
A Microsoft source said pricing disagreements on what the software giant could charge for opening its system were among the most pressing issues now.
"Pricing is certainly a question on the interoperability side — on the protocol side. What royalties can be specifically charged on the protocols" to improve interoperability, the person said.
Microsoft has said it would give competitors a price break on reviewing source code and more time to decide whether they wanted to license it.
During the last high-level contacts in April, EU antitrust chief Neelie Kroes held talks with Microsoft CEO Steve Ballmer at Ballmer's request to seek a breakthrough in the five-year standoff.


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Links, Usability Part 1
About the usability of links in webdesign, and how to avoid accidental clicks on ads.
Edited: 2011-03-16 02:38
In this part I'll try to cover link usability and accidental clicks on Ads.
Accidental Clicks
Some webdesigners tend to rely heavily on accidental clicks. They layout their pages in a bad way, with poor contrast to increase the CTR for their Ads. This will again harm the advertisers, since they will be paying for such worthless clicks.
Usually this means people who click an Ad by accident, thinking it was part of the site, either because it was placed to close to navigation links, or other clickable content, or simply because the site was designed with such poor contrast, that the user got confused. There are no valid reason why Webdesigners should get payed for these clicks.
Note. Its better to simply layout your pages right in the first place, to avoid as many of these Accidental Clicks as possible.
Link Usability
A whole lot of webdesigners, seam to neglect the importance of having visited links apear in a different color, some even remove the difference on purpose, to increase the accidental click through rate.
Visited links and Unvisited links
Some webdesigners remove the difference between visited and unvisited links, this is a very bad idea, since it will be harder for your visitors to keep track of the links they already visited.
Note. Depending on your layout, and how many links you got, this feature actually helps your users to navigate your site.
Generally its a bad idea to disable it. The styles and colors of your links, should hold a suitable contrast to make sure users find it easy to navigate on your site.
Hover effects on Links
Do not neglect the importance of hover effects, this is almost todays answer to underlined and blue links.
Wait, dose this mean that links shouldn't be Blue and Underlined?
Links dosn't nessesarily need to be blue and underlined, its an outdated understanding of usability. With todays modern CSS layouts, its actually recommended to be more creative and thoughtful with your links, both for usability reasons, and for design reasons.
Note. It however might be a good idea to keep them Underlined, so that you don't rely on color alone
And this is only for the sake of user friendliness. Keep in mind that some users may not be able to view these colors the same way as people with normal eyesight.
Be creative with your links, applying a simple hover effect will help your users to navigate your site, by better indicating a link. The majority of users are still registrering underlined text as links, the color however dosn't matter much anymore. So we have 2 good reasons to underline links, 1:) The majority is used to seeing links as underlined. 2:) Its a bad idea to rely on color alone to indicate clickable content.
Its fine to remove the underline on links in navigation menus, and places where its obvious that its a link. But links occurring in the content should be underlined in most cases. This will help users to register a given link, hover effects will help your users in this process, and it adds another level to your layout by making it more graphically appealing.
Sessions vs URL Parameters
Sometimes its better to use URL Parameters, instead of sessions.
One case would be when publishing RSS feeds for Articles on your site dynamically. It might seam like an easy solution to store the number of the Article/Post in a session variable, but this would break your application if your users have cookies turned off in their browser. And it will make crawling the pages harder for search engines, since they might chose to access the feed directly instead of visiting the main article first, or they might not even accept cookies.
These are things to keep in mind about links, the next Article on Usability will cover some basic aspects of layout and contrast.


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Minster FM News
Rail Union Accuses Government of Lying Over East Coast Rail Privatisation
1:09pm 15th May 2013
Rail union the RMT has accused the government of lying over its plans to re-privatise of the East Coast Mainline.
The union claims it will cost the taxpayers hundreds of millions of pounds in lost revenue payments.
Rail Minister Simon Burns was accused by the union of misleading Parliament about the performance of the East Coast Mainline, which is currently owned by the government.
The Minister told the Transport Select Committee on 24th April that the West Coast Mainline operated by Virgin pays more in premium payments than the publicly owned East Coast Mainline. The Minister then repeated that the following day at Transport Questions.
The RMT states Parliamentary answers and official figures recorded by the Office of Rail Regulation show that,
· Publicly owned East Coast Mainline through Directly Operated Railways has paid the taxpayer significantly higher premium payments than Richard Branson's Virgin on the West Coast Mainline. Publicly owned East Coast paid the Treasury £411 million between 2009 and 2012 whilst Virgin's West Coast paid £282 million during the same period. A difference of £129m.
· Publicly owned East Coast through Directly Operated railways also paid almost twice as more (£602m) than its predecessor National Express (£370m) over a four year period.
· New RMT research also shows that Virgin and Stagecoach have paid almost half a billion pounds in dividends to its shareholders while operating the West Coast Line. This could have instead been used to finance an average year on year fare cut of 7 % to help hard pressed passengers if the service had been publicly owned.
RMT General Secretary Bob Crow said:
"The truth is now out, this government is prepared to lie through its back teeth in a desperate bid to privatise the East Coast Mainline even though they are well aware that the whole reckless gamble will cost the British public hundreds of millions of pounds in lost income.
"RMT's research shows that the lost money will go straight into the back pockets of whatever bunch of chancers are given the chance to plunder the East Coast after the previous two private collapses left the public sector to pick up the pieces. RMT will continue to fight not only to keep the East Coast in public ownership but to renationalise the entire network, ending the great rail rip-off once and for all."
But Transport Minister Simon Burns has responded saying:
"During the last three years the Treasury has received £411M and £450M from the East Coast and West Coast rail franchises respectively. This is completely separate from the money the DfT paid to Virgin Rail as part of their franchise agreement so the statement I made is factually accurate. The bottom line is that the plans we have set out are what will drive improvements to rail services and put passengers at the heart of a revitalised rail franchising system."


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Brattleboro owner of Zephyr Designs retires after 40 years
BRATTLEBORO >>After 40 years of serving the customers at Zephyr Designs, co-owner, Robert Clements will retire and begin a new journey in life.
Zephyr Designs, located at 129 Main Street, has been a prominent part of Brattleboro's downtown scene since 1975, selling art supplies and custom picture framing. The members of Clements' staff, who have all worked alongside him anywhere from 10 to 33 years, have acknowledged him as a sociable guy, who is deserving of a thank you or "see you later" retirement party that is open to the public. An open house to celebrate Robert's years as a businessman, will be held on Sunday, Dec. 20, from 2 to 6 p.m at the store.
"At some point you have to make a distinction between what is a job and what is a life's work, and to have been given the opportunity to touch as many people's lives as I have been able to do ..." Clements voiced trailed off, as he cried and tried to continue his thought. "Is so important." Clements reflected on the warm community and described it through a recent instance where someone passing by on the street came up to him and hugged him.
The store will continue to operate during its normal business hours, and Clement's brother, John, will take over Robert's position. John has worked at Zephyr for over 30 years and hopes to expand some aspects of the store such as ready-made frames, which means they are already constructed, opposed to custom designs, which is one of John's specialities at Zephyr Designs. He also hopes to offer a wider variety of papers in the store because he believes that artists often want to physically touch their product to ensure that it is the correct quality, something they can not do through an on-line purchase. Some of these include rice and handmade papers that John said can be used for painting or for the pages in a book.
At an early age Robert established a work ethic; he and his four other siblings were taught hard labor by their father who was an engineer for Chrysler.
"We never had a tradesman in the house," said Robert. "We were a hands-on family." The four siblings helped around the house with painting, carpeting, wiring and plumbing. Robert also had his first job at 5-years-old, where he made car door switches. For every 10 switches that he made, he earned a penny.
"I have been working ever since," said Robert.
As a young man in his 20s, Robert Clements moved from Detroit to Brattleboro in September of 1974 with his black labrador, Bear. They lived in a tee-pee, located in West Brattleboro, for two years until a hurricane hit that left him homeless. Robert diligently saved money while living off the land, and was a dairy farmer by morning and a head chef at Via Condotti Restaurant by night.
Zephyr Designs came into the picture, when the previous owners, Peter and Virginia Vogel approached Robert and offered him a deal where they would finance half of the business selling price of $8,000. The shop was originally located at 51 Main Street, owned by the Vogel's who bought it from its founder, Zephyr Renaud. When Robert bought the framing business, he later expanded it to include a retail store for art supplies, and renamed it Zephyr Designs. In 1982, Robert's brother, John, moved to Brattleboro with his wife, Nancy. John began working at Zephyr, later becoming half-owner and taking over responsibility for the picture framing part of the business.
"It's not about the sale, it's about the service," said Robert. He said they try to work closely with customers in knowing what they want to do with their products, so they can offer them the appropriate tools to complete said project.
"If you provide great service, you don't have to tell people you provide great service, you just do it."
"Retirement" doesn't necessarily mean idleness. Robert is looking forward to having more time to pursue his many interests, including his passions for collecting and writing about minerals and his life-long passion for gourmet cooking. He has signed on as an apprentice to the chef at Asta's Swiss Inn in Jamaica.
"I've always wanted to work in a French restaurant, just to learn," said Robert.
All are welcome to join Robert and his co-workers at the open house Sunday, Dec. 20, from 2 p.m. to 6 p.m at the Zephyr Designs.
"I'm so looking forward to being in charge and making some changes that I want to make," said John. "I am going to miss him, but in some ways I think it may be better this way. Even though we both live in town, we don't socialize that much, and I think that may change more because I won't see him everyday."
If you'd like to leave a comment (or a tip or a question) about this story with the editors, please email us. We also welcome letters to the editor for publication; you can do that by filling out our letters form and submitting it to the newsroom.


text:
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Posted: 10 Feb 2016 13:54
Type: Car
Body Style: SUV
Maker: Nissan
Model: X-Trail
Year: 2005
Transmission: Automatic
Fuel: Gasoline
Engine: 2488 cc
Seats: 5
Doors: 5
Condition: Usage
Mileage: 300000 km
Number Of Owners: 1
Date Registration: 05 Mar 2015
MOT Expiry: Dec 2016
Price: Negotiable
Color: Silver
Location: Africa , Tanzania
Engine position: Front
Engine (cyl): 4
Engine type: in-line
Engine (valves/cyl): 4
Engine power (ps): 179
Engine power (rpm): 6000
Engine torque (nm): 245
Engine torque (rpm): 4000
Engine compression: 9.5:1
Drive: 4WD
Weight (kg): 1842
Length (mm): 4520
Height (mm): 1420
Wheelbase (mm): 2630
Fuel (cap/l): 60
Show more features
The Nissan X-Trail arrived in 2001 and has been of top choice as regards soft roader market. In 2WD, drive is to the front wheels, Auto mode feeds most torque to the front axles but shuffles additional torque to the rear when slip is detected, while Lock mode gives a fixed nearly equal front/rear split and is available for tougher conditions up to 30km/hr. It is a preferable SUV for its comfortable seats and general safety features. This utterly unobtrusive ride, quiet, comfortable, and easily manoeuvrable, it is a widely preferred brand and model by most families. Built for inner town commuting of passengers, it also holds its ground in the aspect of off-road handling, as it provides a smooth drive always.
Additional Data
Interior: Air Condition AM/FM Stereo CD Audio System Cup Holders Driver Airbag Passenger Airbag
Exterior: Alloy Wheels
Equipment: Anti-Lock Braking System Keyless Entry Power Door Locks Power Steering Power Windows
Contact Person: Saber International
Email: firstname.lastname@example.com
Phone: 0719559500
Coopera teWith Us »
We are looking for partners all over the world to work with bizcyclone.com Interested persons and companies please contact us on email - john.paul@aesl .co.tz Details >>


text: The competency profile of online BMA graduates viewed from a job market perspectiveÀngels Fitó Bertran, María Jesús Martínez Argüelles, Soledad Moya GutiérrezInternational Journal of Educational Technology…2015One of the cornerstones of the European Higher Education Area is its emphasis on a higher education that prepares graduates for a profession. Within this context, competencies play a key role in the design of degree courses because they constitute dynamic elements that enable higher education institutions to address the changing needs of society. In this… (More)


text:
Construction Consumer Products Metals & Materials Safety Environment Transportation Chemicals Energy Medical Quality
ASTM Seeks Applicants for Graduate Scholarships
ASTM is now accepting applications for its graduate scholarships. The ASTM International Graduate Scholarship is presented each year to as many as four high potential graduate students, contingent on merit and available funds. The scholarship rewards graduate students who have demonstrated high levels of interest in or involvement with ASTM standards. Each recipient of the scholarship will receive $10,000 to be used for educational expenses.
Applications are due April 30. For more information, look for the ASTM International Graduate Scholarship here, or contact James Olshefsky, ASTM International (phone: 610-832-9714).


text:
Vernon (Eure) : Car Rental 20% Discount!
Economy Car Rentals and news about Vernon (Eure)
The goal of Economy Car Rentals is to help you to plan your Vernon (Eure) trip the easiest possible way. For this purpose we have summarized important information for you. Read the latest news and articles reporting about Vernon (Eure). Enjoy your trip to Vernon (Eure) and make everything right from the start by being organized. The absolute freedom provided by a car rental from Economy Car Rentals.
Tips for a Car Rental
Coming to the airport of Vernon (Eure)? How advantageous for you since you can pick up your car rental right here. Organize your car rental with Economy Car Rentals. Here you can find what you should consider and be aware of before arriving in Vernon (Eure) but can also read about other driving tips. Get in the car and off to the adventures expecting you during your holidays! The Information Pages of Economy Car Rentals are updated daily. Has your interest been raised? Go on reading. Every moment with a car rental from us is enjoyable. Find out for yourself what more is there to offer.
Find a convenient car for you: Mercedes E-Class, VW Polo, Ford Focus, VW Passat, VW Jetta, BMW 1series, BMW X3, Renault Twingo, Citroen C1, Mercedes C-Class. To enjoy your car rental, we would suggest you to select the most convenient category such as Mini, Minibus 5 seater, Full Size A/C GPS, Full Size GPS.
News, articles or press for Vernon (Eure): Book Your Car Rental Here
Information and News for:
Last Updated 2015-02-21


text:
Simpson's Single Adult Housing programs provide subsidized supportive rental housing and services to single homeless adults. In 2015, we assisted 114 people in OHP and WHP programs. There are 3 programs within Single Adult Supportive Housing:
Rapid Rehousing: Simpson provides financial assistance and services to prevent individuals from becoming homeless and help those who are experiencing homelessness to be quickly re-housed and stabilized.
Women's Housing Partnership: The Women's Housing Partnership is a groundbreaking outreach program for women who faced long-term-homelessness. Despite diverse challenges such as mental illness or chemical abuse, 80% maintained stable housing in 2015. Staff members work intensively with program participants to forge ongoing relationships that foster individual strength and support progress towards personal goals.
Opportunity Housing Partnership: Simpson partners with Aeon and RESOURCE Chemical and Mental Health to provide increased supportive services in two buildings in downtown Minneapolis. The properties offer efficiency apartments for long-term homeless individuals, and residents are connected to ongoing case management and opportunities for community engagement.


text:
Discharge permit challenges
Troubleshooting one industry that required multiple procedure modifications
Troubleshooting one industry that required multiple procedure modifications
New technology installed at the Blue Plains Advanced Wastewater Treatment Plant in southwest D.C. will produce about one-third of the plant's energy needs.
The reduction in utility power will help the city reduce its carbon dioxide emissions by 2,835 tons.
TREVOSE, Pa. — The facility earned GE's Ecomagination Award for also decreasing copper corrosion.
WOODBRIDGE, Va. — The plant has gone six years without a violation.
FAIRFIELD, Conn. — The update allows customers to have access to GE's subject matter experts.
DALLAS — Inspectors found sanitary sewer overflows and an excessive amount of e. Coli in the discharged effluent.
SINGAPORE — The company will cultivate a reliable water source at the Phu My pumping station for 5,600 hectares of land.
To overcome water scarcity and other problems, one solution to effectively lessen the need for fresh water sourcing for industrial purposes is to reuse or recycle the water presently used for cooling purposes.
IOWA CITY, Iowa — Stanley Consultants led the design team for Iowa City's $50.2 million wastewater treatment expansion at the city's South Plant.


text:
|19 May 2013
Attached is the FSS report. And when i went to download junction.zip, i got an error. I also attached that a screen shot in MS Word.
|My System Specs
|19 May 2013
Try downloading from here: Junction
|My System Specs
|20 May 2013
hello Cottonball. i Ran that file as requested, and the DOS screen is just hanging with a blinking cursor. Is this normal?
|My System Specs
|20 May 2013
We are not done.
The infection you were initially confronted with also brought with it a new malware variant that affects Microsoft Security Essenials and/or Windows Defender. It creates symbolic links to their folders and files, which, in turn, affects path-name resolution. In plain English means "can't get there from here".
This infection is very recent, so we had no idea what it was, or, what was involved. Taking care of this variant of ZeroAccess should also restore the ability to download files.
For now, please do not engage in any other repairs, as they will not help matters.
Need to take a good look at the last report you provided which identifies symbolic links. There are quite a few of them, but, it appears that Microsoft Security Essentials is not involved.
More than likely, will not get back to you until tomorrow.
Thank you for your patience.
|My System Specs
|20 May 2013
That is fine... I can not thank you enough for helping me out with this. what ever it takes i'll be patient. You, VistaKing, and Jacee are a life saver!!! you told me that you get paid by reps. Please tell me how to do that.
Thanks again!!!
|My System Specs
|20 May 2013
We're dealing with a brand new infection, so, have to proceed cautiously.
Thank you for being so patient.
|My System Specs
|20 May 2013
One more item, tonight, if possible.
Please remove the old copy of FRST64, the already used fixlist,txt, and the fixlist report from the Desktop. Then, download a new copy of the Farbar Recovery Scan Tool Download
Select the 64-bit version.
Save it to your Desktop.
Next, copy/paste all the text inside the quote box to Notepad (Do not copy the word 'Quote')
Unlock: C:\Program Files\Windows Defender
Folder: C:\Program Files\Windows Defender
In the Save as prompt, name the file fixlist.txt, and save it to the Desktop <<---Important!!
NOTE. It is important that FRST64 and the fixlist.txt are in the same location (Desktop) or this will not work.
Now, run FRST64 and press the Fix button, just once, and wait.
When done, the tool makes a log on the Desktop: Fixlog.txt
Please post the new Fixlog.txt in your reply.
|My System Specs
|21 May 2013
Please press on with the previous post, but, only get a new copy of the Farbar Recovery Scan Tool Download
Disregard the rest, if you have not done the task, and do the following:
(If you have already done the above, then post the results. No problem.)
We need to scan the system with a special tool...
|My System Specs
|21 May 2013
i didnt do the first post. just the findjunction program.
|My System Specs
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text:
Forget what you see in fake Hello and OK magazine spreads, this is more like it! These are pictures of what Mike Tyson's mansion, found in Connecticut, look like now that he has left.
The pictures come from llicitohio.com, a company that takes trips through abandoned buildings to take photographs.
Whilst evidence of Tyson is still very much present in the house, he has not actually owned the home since the late 1990s. It is currently abandoned as the home is actually owned by a business man who is at the center of an investigation.
These images remind me of the Neverland Ranch pictures which came out a few years ago in which Michael Jackson's estate looked really sad.
Abandoned Celebrity Mansions
More Stats +/-
Romantic Wood Jewelry
Luxe Nylon Accessories
Transparent Whisky Spirits
Virtual Takeout Restaurants
Prideful Furniture Campaigns


text:
In her startlingly sensual story Rules for Virgins, beloved best-selling author Amy Tan (The Joy Luck Club, The Bonesetter's Daughter) takes us deep into the illicit world of 1912 Shanghai, where beautiful courtesans mercilessly compete for the patronage of wealthy gentlemen. For the women, the contest is deadly serious, a perilous game of economic survival that, if played well, can set them up for life as mistresses of the rich and prominent. There is no room for error, however: Erotic power is hard to achieve and harder to maintain, especially in the loftiest social circles.
Enter veteran seducer, Magic Gourd, formerly one of Shanghai's "Top Ten Beauties" and now the advisor and attendant of Violet, an aspiring but inexperienced courtesan. Violet may have the youth and the allure, but Magic Gourd has the cunning and the knowledge without which the younger woman is sure to fail. These ancient tricks of the trade aren't written down, though; to pass them on to her student, Magic Gourd must reach back into her own professional past, bringing her lessons alive with stories and anecdotes from a career spent charming and manipulating men who should have known better but rarely did.
The world of sexual intrigue that Tan reveals in Rules for Virgins actually existed once, and she spares no detail in recreating it. But this story is more than intriguing (and sometimes shocking) historical literary fiction. Besides inviting us inside a life that few writers but Tan could conjure up, the intimate confessions of Magic Gourd add up to a kind of military manual for the War of the Sexes' female combatants. The wisdom conveyed is ancient, specific, and timeless, exposing the workings of vanity and folly, calculation and desire that define the mysterious human heart.
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Loved it - oh so briefly!
- Quiltrobin
Where was my Magic Gourd?
Captivating, interesting and informative.
I felt as if I was Violet listening to a wise mentor, envisioning myself as a courtesan.
This book is short about 2 hrs, my biggest problem was it was hard to work and listen to since it was very detailed.
- Marilyn


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Re: Toledo, Ohio Cemeteries
In reply to:
Re: Toledo, Ohio Cemeteries
Pat Haskill 9/21/00
Hi Pat,
I didn't remember Mom telling me we were related to Haskill too until I saw your name. Maybe she knew of your marriage or perhaps back when.
I've heard the name Rummel, but know for a fact she said Northrup as I worked with someone way back by the name.
I saw you had a Nye in OH, the only one I knew I met when I was 8 or 9 at a family reunion at out farm in OH.It was for the Woolley name however they spelled it.The only thing I remember is the back of his head, married, about 2 children I think and then lived in Springfield, OH.Mom and Dad would go visit, but we stayed home, too many children they didn't take us along.I doubt he is alive any longer, so far as I know I am the older generation.
Just wanted to say hi.I don't know how he was related, but he was there and everyone was glad to see him.I think his name is/was Bill.That's all I know.


text:
Facial Attraction Melbourne Cathyr
Welcome to Facial Attraction
Melbourne's Leading Skincare Clinic
Facial Attraction is a boutique Skin and Beauty clinic with two locations across Melbourne's suburbs.
Our treating clinicians have undertaken extensive training and have significant industry experience ensuring the safest and most appropriate treatment of your skin.
Look and Feel Younger And Healthier
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Cosmetic Injections
Innovative Range of Anti-Aging treatments including cosmetic injections
Beauty Treatments
Look and Feel Refreshed With Our Range of Beauty Treatments.


text:
- NicknameMenace
- PositionJammer/Blocker/Pivot
How I found PRG?
My friend and I did some research after watching a certain roller derby movie. We became instant fans and went to all the bouts we could. It only took four years for her to convince me to try out!
Worst Injury To Date?
Two sprained ankles and a stress fracture in my foot.
Derby Moment I'm Most Proud Of?
Passing fresh meat assessments and playing in my first CheeseSkates game!


text: Hi Guys, I've noticed that recently my A4 B7 has started making a sort of knocking/banging sound from the rear. It is only really noticeable at slow speed - mostly when stationery and then reversing or when going down an incline and coming to a stop. I'm thinking it must be a suspension bush somewhere that's knackered or perhaps an ARB bush? Initially I thought it was the sound of the petrol moving in the tank as I read a similar thread that suggested this. However it seems to do it even with a full tank. Any ideas? Cheers Alex


text:
MOVIE SYNOPSIS [ General Audiences ] This story of survival is the true story of Mohamed, a Somali pirate, from their point of view. The director takes a new hybrid approach, to try to understand how Mohammed came to lead a brutal and dangerous existence. You can watch The Last Hijack online on TV cable or theaters with original audio in Dutch at different dates. This film premiered in theaters in 2014.
Rating: 5 by 220 users./
Runtime: 83 minutes
Documental, Animation.
83-minute film (full movie) directed by Tommy Pallotta and Femke Wolting.
The original audio of The Last Hijack has dialogues in or Dutch, it was produced in Netherlands.
It premiered in cinemas or television in 2014.
Screenplay written by Tommy Pallotta and Femke Wolting.
Abraham Haile Biru and Ahmed Farrah.
This film was produced and / or financed by Submarine, Razor Film Produktion GmbH and Savage Film.
Composed by Kreidler.
Without commercial breaks, the full movie The Last Hijack has a duration of 83 minutes; the official trailer can be watched in streaming on the Internet. You can watch this full movie free in English or Dutch in movie TV channels, renting the DVD or with VoD services (Video On Demand player, Hulu) and PPV (Pay Per View, Netflix).
See the page of this full movie, The Last Hijack in FULLTV Movies.


text:
Independent You Senior Services
About Independent You Senior Services9489 Silver King Court
Fairfax, VA 22031
Price & Availability: (855) 757-9233
General Info: (703) 999-3006
Fax: (703) 279-8134
Provides services to: seniors
Service Area for Independent You Senior Services
About Independent You Senior Services
Independent You offers a variety of services including care management, personal care, companion care, driving services and relocation services. Additionally, we provide specialized services such as bill paying, records management, assistance with home repairs and home safety evaluations.
We provide high quality, client centered and affordable home care services so that seniors are able to lead dignified and independent lives in the comfort and safety of their own homes. Their individual needs are carefully assessed, understood and met through the selective assignment of qualified and trustworthy, and compassionate personnel. We seek to enrich the lives of the seniors that we serve.
Our Care Management is provided by Geriatric Care Managers (GCMs) who are health and human service specialist and may be trained in a number of fields including; gerontology, social work, psychology, and aging or elder care. Independent You GCMs conduct a care plan assessment in your home and formulate a care plan specific for each client. We will help to institute residence care, review financial, legal and medical issues and make appointments and referrals when necessary. We act as a liaison between our clients and medical providers and seek to educate our clients and their families.
Whether you're seeking assistance for yourself, a family member or friend, that's where Independent You is there to offer a helping hand by providing personal care or companion care. that is overseen by our registered nurses. We can help with everyday tasks so you can spend your free time doing the activities you most enjoy.
What sets us apart from all the other agencies? Details. We pay attention to the details. Sometimes it can be the small things that make all the difference. Our caregivers pay attention to the details of your life. We find out your likes and preferences....all the little details that make up you. Then our care is centered around those details. Our clients go to movies, go to musical performances, attend church services, visit with friends, write letters and send cards to family and friends, go for walks or hikes, sing and listen to music, the list is endless. We enrich the lives of the seniors we serve.
Overall Rating 5.0 / 5.0 ★★★★★
Selena Wilberforce -Akogyiram★★★★★ a year ago
Independent You Senior Services Services
- Private Duty Home Care
- Home Care
- Home Health Aid
- Medical Social
- Nursing Care
Cities Served by Independent You Senior Services
Independent You Senior Services serves ZIP codes that encompass all or part of each of the cities listed below.
Annandale, VA
Chantilly, VA
Falls Church, VA
Springfield, VA


text:
1200 Rouge Rd, Shasta Lake, California
$35,0002 Beds1 BathActive
$35,0002 Beds1 BathActive
1200 Rouge Rd, Shasta Lake, California 96019 - Being sold for land value only. 1967 double wide in poor condition. Large corner lot. Outbuilding on the property.
Listing Courtesy of WILSON REALTY INC.
"I am so impressed with the quality of service provided by Chris, Maria, and their team. They are on top of their game and know all the intricacies of the real estate market here in Redding, CA. Whether you are listing your home or looking for a home to buy, I would highly recommend the Jeantet team!"


text:
Dept 56 North Pole Series Popcorn and Cranberry House In original box. LOOK!!!!
Sold for:
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- Sold Date:
- Source: eBay
Up for auction is the Dept 56 Popcorn & Cranberry House" North Pole Dept. 56 Item #56388. Introduced 1996 and retired 1997. This special piece was only manufactured for one year so they are in precious short supply. Tall chimney separates front part of house from rear work area. Elves work on the berries and corn preparing them for stringing into garlands and creation of holiday trim. Berries trim front sign accented by red roof, door and windows. Hanging lantern over front door is separate in box. Size: 6 x 5.25 x 8.25" Mint condition piece in original box & sleeve.
Retail cost was $45.
I am selling over 160 Dept 56 items for a not for profit organization so check back often or ask if you are looking for a certain piece. Payment is expected within 3 days of auction ending. I DO NOT ship outside of the US!! I would be happy to send more photos and all items come from a smoke free home! Low starting bid!!! Don't miss out!!!


text:
I have the Courage, the Strength, and the Motivation.
I will let the Judgment Fade away.
I will let the truth Empower and Liberate me.
I will allow myself to be Happy and Reach out for Support when I need it.
I have the Resilience and Self -Determination to make it happen!
And what I want for you, the students, is to recognize and embrace your Courageous & Remarkable Self!
So I dedicate this blog to you – Students of Middle School, High School, and College.
With that in mind, I'm ready to take a risk, not hold anything back, all with the intention of living out my destiny. I plan to accomplish this by sharing my stories, my lessons and mistakes, embarrassing moments, my challenges and successes, my secrets of resilience and determination, my knowledge/insight, and resources with you - all because I feel a great sense of responsibility to do so. Therefore, today I chose to embrace the unknown and allow myself to feel liberated – all so I can become a better version of myself and for you to benefit and learn from everything I share.
Are you ready to join me?
Let's stay connected!
Join the Courageous & Remarkable Self Movement.
So I can keep supporting you!


text:
A tragedy happened recently near Mesquite, Texas, when a child drowned in a pond adjacent to a park. The father of the child momentarily turned his attention away from his daughter. She discovered a path that led to the pond, which is up to eight feet deep in places.
Woman killed in fatal car accident in Dallas
All drivers in Texas have a legal duty to do everything possible to operate their vehicles safely on the road. This means, among other responsibilities, maintaining attention to the traffic conditions ahead, and reacting accordingly. Unfortunately, serious rear-end accidents are often caused by a driver's failure to maintain such attention.
Fatality numbers may rise as GM revises defective product data
Some might say that the news for General Motors just keeps getting worse. But in reality those getting the bad news are consumers who purchased GM vehicles with an automobile design defect. The defect, in the form of a faulty ignition, has reportedly led to the deaths of 13 people.
Texas teen paralyzed in 'affluenza' crash settles for $2 million
One night last June, a North Texas teenager's life was destroyed after he got in the back of a pickup truck driven by another teen who had been drinking. In a matter of seconds, the passenger's life changed dramatically.
Drunk driver hits 4 people outside Plano bar, leaves scene
One of the most dangerous things a driver can do is get behind the wheel of a car after drinking too much. We all know that intoxication can slow a person's reaction time, cause blurred vision and lead to poor decision-making. All of these things can lead to a serious car accident. Unfortunately, many people in Texas still choose to drink and drive.
Texas car crash claims the life of third victim
Various musicians gathered for a popular music festival recently in Texas. Expecting fun and entertainment, many people congregated in the closed off streets to watch the performers. An otherwise pleasant evening quickly came to an end after an allegedly drunk driver caused a car crash that claimed the life of multiple victims and injured several others.
Teenager dead, another injured after Texas car crash
Icy road conditions are relatively uncommon here in Texas, so driving during winter weather can be especially treacherous. Even those who exercise extreme care can still find themselves in an accident. Sadly, icy roads appear to be a factor in a horrific car crash that killed a popular high school student in Justin recently. Her friend sustained serious injuries. In the aftermath of the tragedy, classmates, teachers and the community have rallied to show their support for the deceased girl, her family and the injured teen.
Texas students should be aware of possible emotional trauma
Cell phones are widely popular and used daily by a large percentage of the nation. Everyone from middle school students to elderly adults in Texas are getting cell phones to keep in contact with loved ones and friends. But what happens when a cell phone causes severe pain and emotional trauma?
Negligent parties sued for injuries caused in a Texas car crash
Operating a vehicle is a very large responsibility for every single driver. Not only is it an obligation to drive safely in order to keep oneself from getting injured, but it is also to keep from injuring or killing others on the road. In Texas, negligent parties who are determined to be the cause of driving-related injuries or deaths can be sued for compensation after the accident.
Texas car accident leads to man filing personal injury lawsuit
Being injured in any manner can be traumatic or hard to handle, both emotionally or financially. The reason people pay for insurance policies on their vehicles in Texas is so that -- when a car accident occurs -- they do not have to pay out of pocket for the damages or medical payments. But what happens when insurance doesn't pay when a claim is filed?


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high-throughput screening
High-throughput screening (HTS) involves the screening of compound libraries at a single concentration using biochemical or cell-based assays that are directed against a drug target or a desired phenotypic outcome, followed by confirmatory secondary dose response assays.
Automated dispensing reduces the tedium and repetitiveness and potential for error inherent in manual pipetting. This allows the setup and study of large numbers of microplates or microtubes for large-scale screening studies.
find out how we can:
related products
High throughput screens (HTS) routinely require low volume dispensing technologies to reduce assay costs by minimising reagent and sample usage for a wide range of applications within academia and the drug discovery industry.
dragonfly discovery offers positive-displacement, non-contact, liquid handling and eliminates issues with clogging while providing reliable, accurate dispensing, agnostic of liquid class; reducing assay development time and improving robustness in screening.
- rapid and reliable low volume (200 nL upwards) dispensing from a positive displacement disposable pipette (with 4 mL capacity)
- 96, 384 & 1,536 well compatibility
- integration friendly with optional auto-feed reservoirs
- new software capability and UI to aid the design and development of complex assays, specifically in high density plate formats
A pre-requisite for efficient screening is rapid, automated selection of hits for confirmation and secondary profiling.
mosquito HTS offers an accurate and easy-to-use-solution to miniaturising any assay within an automated, high-throughput setting. Volume range is 25 nL–1.2 μL, which can be expanded to cover 25 nL–5 μL in conjunction with mosquito HV. By using mosquito's unique positive displacement pipetting technology, dead volumes are minimised to under 0.3 μL.
Application areas include:
- serial dilutions
- plate reformatting and replication
- acoustic plate source creation
- next generation sequencing
- genotyping
- high-throughput MALDI-TOF MS
mirrorball no-wash multiplex immunoassays for biological discovery
With over 40% of therapeutic drugs targets currently being membrane-associated proteins, the study of monoclonal antibodies for both immunodiagnostic biomarkers and therapies is a large growth area in the pharmaceutical industry.
Key applications include:
- biologics screening:
hybridoma, phage display, B-cell cloning, antibody fragments, peptides, scFv, Fab
- binding characterisation:
Ki determination
- functional assays:
ell cycle, cell signalling & proliferation
- quantification of soluble proteins:
cytokines, hormones, growth factors
acumen Cellista is unique in providing the value of a medium content approach to multiplexed cell-based assay screening in a format that is manageable and approachable for high throughput screening (HTS).
- don't compromise speed for content: acumen Cellista brings biological relevance to your required throughput levels, enabling full library screening to ensure you never miss that potential blockbuster without the infrastructure requirements of high content solutions
- immediate decision-making data: acumen Cellista's cytometric approach delivers instant results and small file sizes so you don't have to spend valuable time validating data, or managing a data mountain
- be productive straight away: acumen Cellista is simple to operate without the need for specialist users or endless ongoing training
TTP Labtech's comPOUND sample storage system gives you the ability to:
- select any library subset quickly to meet the needs of your screening department
- reduce potential damage to library stocks by only cherry-picking the samples you need
- ensure sample integrity with temperature controlled, dry, inert, hermetically sealed environment
- ensure throughput grows with your library by processing samples in parallel
- easily expand your sample storage capability. Additional modules can be integrated in response to growing library size
arktic automated storage of cell, RNA, siRNA, DNA, native proteins (-80°C)
arktic is a low cost, compact storage unit which provides unrivalled storage density, full sample tracking and rapid retrieval.
To ensure viability and reduce sample degradation it is vital to minimise the risks of thawing, either within the cold zone or during sample selection.
arktic provides:
- easy sample access and stable temperatures to give you unrivalled robustness and reliability for your -80°C storage requirements
high-throughput screening applications:
Compound Screening
Compound screening is an essential part of the early stage of the drug discovery process, to identify molecules that have activity on specific drug targets. Compounds identified as "hits" are further optimised using traditional medicinal chemistry (combinatorial chemistry) to determine chemical groups responsible for evoking a target biological effect or structure-activity-relationships (SAR). With such large numbers of compounds and chemical entities in compound libraries, the removal and handling of large numbers of samples from stores for assay set up can be a complex and time consuming process.
TTP Labtech's self-contained biobanking modules, comPOUND and arktic, can be placed in remote locations to maximise valuable laboratory space. Using TTP Labtech's pneumatic transport technology, sample tubes can be rapidly selected and transported to any laboratory without the need for manual intervention, thus improving the research workflow.
Aliquot transfer from stock plates or vials, serial dilution and plate preparation and replication require accurate but repetitive and time consuming pipetting, as well as meticulous sample labelling, tracking and management. As such, the ability to automate sample dispensing and processing is invaluable, providing reproducible and accurate volumes and significantly decreasing the turn-around time from compound synthesis to assay ready plate production.
TTP Labtech's mosquito range of liquid handlers allow rapid, accurate, reproducible nanolitre volume compound dispensing for high speed plate set-up, irrespective of viscosity or environmental conditions.
Pharma and biotech companies today perceive they have to compromise between the convenience of target-based screening and the relevance of phenotypic screening. TTP Labtech's acumen Cellista laser scanning imaging cytometer (LSIC) overcomes the challenges associated with full compound library phenotypic screening, allowing users the flexibility to choose the most appropriate strategy.
acumen Cellista is unique in providing the value of a high content approach in a format that is both manageable and approachable for high throughput screening (HTS).
Phenotypic Screening
The realisation that more first-in-class drugs have been discovered by phenotypic screening than by target-based screening has led the industry to revise the strategy for identifying new drug candidates. The emergence of novel technologies and advances in cell imaging has made it possible to re-consider phenotypic screening as a serious contender for drug development. Whilst the advantages of this approach are clear, implementation within a HTS setting can be complex as discussed in this white paper. With plate read times as low as 2 and a half minutes per plate regardless of plate format acumen Cellista offers a manageable solution for medium content HTS screens to bring improved physiological relevance over plate reader assays without the burden of a or throughput limitations of a microscope-based high content approach.
Our e-book, put together in collaboration with Genetic Engineering and Biotechnology News is devoted to phenotypic screening. It discusses the use of 3D cell cultures as a more physiologically relevant screening model for evaluating new drug candidates. They more closely resemble the structure, activity and extracellular environment of tissues in-vivo and therefore are more likely to be predictive of how cells will react in-vivo. Our interactive learning tool is available to download anywhere at any time and additional information can be found in the interactive bonus videos and a recent poster of a high throughput screening method to analyse the growth of tumour spheroids and colonies.
Find out more about phenotypic screening with acumen Cellista or, read our e-book here
Biologics Screening
Immunoassays have been, and are still, an essential tool during many stages of the drug discovery process, but these assays can become a bottleneck due to limited throughput and capability. ELISAs are simple and inexpensive but can only detect one target thereby numerous individual assays are required to measure multiple targets. Newer approaches address some of these limitations through multiplexing or homogeneous assay formats; however, these often result in greatly increased reagent and consumable costs. Many are limited in flexibility to just immunoassays, whereas more versatile systems such as flow cytometry are generally less suited to a screening environment. Find out more about how the mirrorball fluorescence cytometer is able to help remove some of these bottlenecks here.
Genomics Screening
RNA interference (RNAi) is a biological process in which RNA molecules inhibit gene expression. Two types of small ribonucleic acid (RNA) molecules, microRNA (miRNA) and small interfering RNA (siRNA) are central to RNA interference. RNAi has become a valuable research tool, both in cell culture and in living organisms, because synthetic dsRNA introduced into cells can selectively induce suppression of specific genes of interest.
By identifying gene products whose knockdown is associated with phenotypic changes, large-scale RNA-mediated interference screens have demonstrated previously unknown components of biological pathways.
The acumen Cellista laser-scanning imaging cytometer is ideal for screening RNAi studies both in cell culture, e.g. cell cycle analysis and toxicity testing, and in whole organisms such as C. elegans or drosophila. acumen Cellista combines whole well scanning with the ability to measure object number as part of the same assay, which gives researchers the capacity to normalise responses. This capability provides an inbuilt indication of cell proliferation, cell toxicity, or can be used to quality control effects such as patchy cell growth within the well which can be missed when only capturing data from limited fields of view.
acumen Cellista's high-throughput capability and rapid 'on the fly' analysis means it can conduct genome-wide screens in a matter of hours rather than weeks.
Toxicology Screening
Cell health (cytotoxicity) assays play a key role in the early drug discovery process as they study the effect of chemical substances and lead compounds on cells. The early identification of off-target drug effects results in more timely elimination of unsuitable lead compounds, which serves to reduce drug development costs. Not only do cell health assays provide a crucial means of ranking novel compounds during screening but they are also routinely employed to gain a better understanding of changes at the cellular level in disease pathologies.
Cytotoxicity assays commonly employ a multi-parametric approach enabling the capture of both phenotypic and mechanistic information. High content screening of the effect of lead compounds on multiple key cellular parameters such as plasma membrane integrity, DNA damage or synthesis, mitotic arrest, apoptosis, cell growth or motility is achievable through the use of high-throughput in-vitro cell-based assays.
TTP Labtech's acumen Cellista high content imager is an ideal instrument for performing a wide range of multiplexed cytotoxicity assays. acumen's laser scanning approach enables scanning of entire wells, cell by cell.
These assays include:
- live/dead – using standard dyes such as calcein-AM/PI or TOTO-3/TMRMThese combinations provide a more cost-effective approach to bulk read assays, such as CellTitre–Glo®, and offer the benefit of multiplexing with additional phenotypic assays to gain more high content data
- apoptosis – annexin V, Caspase-3, nuclear condensation
- genotox – phophohistone H3
With plate read and analysis times as low as 2 ½ minutes, regardless of plate format, acumen Cellista can be used for primary screening in the determination of off-target drug effects in the earliest phases of drug discovery. Fast scan times and easy to use Cellista software mean it is ideal for multi-user environments such as core screening laboratories.
other cell biology applications
Major areas of cell biology research for the elucidation of disease mechanisms and drug discovery are study of cell structure and function, such as cell surface receptors, cell metabolism and homeostasis, and intra-cellular pathways and communication.
It is generally recognized that the study of cellular systems provides superior quality data to biochemical assays. The ability to study the molecular effects of a compound in a specific and relevant cellular context is of great advantage in the drug discovery process.
Cell-based assays have been successfully adapted to the high content screening (HCS) environment of today's drug discovery industry, using a range of cell reagents (recombinant cells, antibodies, fluorescent probes, siRNA etc) and automated cell-based assay platforms, which employ a range of detection modes such as fluorescence, electrophysiological or imaging readouts.
TTP Labtech's instrumentation can help automate and take the tedium out of routine plate set-up, assay development and screening in the cell biology application areas. We're here to help, why not arrange a time to personally review your discovery processes with one of our specialists?


text:
Sunderland vs Southampton 02/15/2014 Free FA Cup Soccer Pick and Preview
Southampton vs Sunderland
Saturday 15th February 2014 12:45(GMT)
The Line: Sunderland 5/2 Draw 23/10 Southampton 11/10 See the Latest Odds
TV: BT Sport, NBC Sport, Direct Tv
Sunderland have won four of five and have given themselves achance at survival in the league. Gus Poyet has revitalised the club and the team, every player seems re energised and the blackcat fans have been terrific especially in the Stadium of light. Adam Johnson, Fabio Borini, in particular have come into form of late. Johnson has been spectacular and Sunderland fans have to be impressed with the re emergence of the former Manchester City player who will surely cemented himself a place on the English World Cup squad if his recent form continues.
Southampton are unbeaten in eight games and have solidified their position in the league with that great run, sitting only three points behind Manchester United the Saints andmanager Pochetinno have to behappy with their recent form. Lallana, Lambert, Shaw and Rodriguez have been having terrific years thus far. Shaw in particular has been lighting up the field and is attracting attention from Chelsea, Manchester United and other big European clubs with a £20million price tag being bandied about.
This is one of those games that jumps out at me, I like the both teams to score market here. I think Southampton have been excellent of late but equally Sunderland are on a really good run themselves. The two teams met in the league a couple of weeks back in Sunderland and that game finished 2-2. I actually wouldnt be surprised if we seen a similar scoreline here tomorrow. But my tip is to take both teams to score and cash a winner. Follow me on twitter@antonpippo


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Washing machine repairs - Ealing(3 Posts)
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Since we moved over the hills a few years ago, my wife and I keep trying Lamorinda and Walnut Creek places, hoping some of them will be in the same league as the west side of the tunnel. Sadly, few are: Lily's House, Hanazen, Artisan Bistro. I would now add Ottavio, a new Italian place just north of Prima on Main St in WC, to the list.
Focus seems to be on the pastas, and we got a tagliatelli with goat ragu. The pasta itself was great, just the right amount of chew. The ragu had a good deep mildly goaty flavor, though it was a bit dry and not as complex as the best ragus I've had. Still good though. The grilled squid salad was outstanding, with the squid nicely charred and tender.
To do the O-town comparison, we thought it was better than Bellanico (which is probably the closer comparison in terms of menu) but not as good as Pizzaiolo or Dopo. Still, that's pretty darn good for WC.
5008 Telegraph Ave, Oakland, CA 94609
4293 Piedmont Ave, Oakland, CA 94611
Lily's House
3555 Mt Diablo Blvd, Lafayette, CA 94549
87 Orinda Way, Orinda, CA 94563
4238 Park Blvd, Oakland, CA 94602
Artisan Bistro
1005 Brown Avenue, Lafayette, CA 94549
1606 N Main St, Walnut Creek, CA 94596


text: I was very fit and in the best shape of my life when the fibro hit. It has been very hard to accept help and the fact that there are so many things that I cannot do. I also had to leave my job but fortunately I have found a new job that works great for me. So I'm learning how to adjust to this new life. I have gained 20lbs since my diagnosed, from the meds they put me on. I'm trying hard to get some control back but I know that it will take me time. I also have come to terms with never being without pain. Fortunately my pain isn't the biggest part of my fibro. The fog and fatigue get me more. I guess what I'm trying to say is, things will get better. You will learn how to deal with your limitations. You will have good days and bad days but you will be ok and when you are having bad days, we are here for you!


text:
Smashwords Edition
This ebook is licensed for your personal enjoyment only. This ebook may not be re-sold or given away to other people. If you would like to share this book with another person, please purchase an additional copy for each recipient. Thank you for respecting the hard work of this author.
This is a work of fiction. All characters or incidents are a figment of the author's imagination and any resemblance to any incident or any person living or dead is purely coincidental.
Chapter 1
Movement of the truck made Zendo look up from the computer. Puri, his cousin and trading helper, must be starting supper. Zendo glanced out the truck window at the sun setting in the west where wisps of clouds turned green and gold in the fading light. The lengthening shadows were bringing the jungle alive with the nocturnal animals.
He had spent the last hour scrunched up in the rear of the truck cab working on the books for his trading company. He grinned as he looked at the bottom line on the computer screen and stretched to relieve cramped muscles. Two more months like this and he would be able to marry Illy, his mountain sweetheart.
He thought back to how he had met her when he accompanied the star traders as a guide. Illyad and her cousin Odessa had been hunting the gemstones for the healing bracelets when the Guardians had scented blood from Odessa's accident. The Guardians were shark-shaped beasts with four legs which had all the attributes and attitudes of their water cousins. When they went into a feeding frenzy, they could rip a person apart in just a few seconds. Zendo remembered how Ron Calvin and Gus Ghaolh had fired their stingerrays to stun the Guardians while he got Illy and the injured Odessa loaded onto the star traders' fliter. His first meeting with Illy hadn't gone very well.


text:
Tag Archives: Walking Tanks
Alford Notes: Amazing Spider-Man #26
When we last saw our hero, he was defending Aunt May and Harry from an attack while attending a charity gala. Will he be able to save them? Will Harry reunite with his estranged father? Will Mockingbird and Spider-Man ever have a minute alone to work out their feelings? …


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Russian president Vladimir Putin says the Obama Administration is "pathetic."
On September 4, Putin opened the G20 Summit in St. Petersburg, Russia and expressed his frustration with U.S. Secretary of State John Kerry. "He's lying, and he knows he's lying," Putin said.
He is now blaming the Obama Administration and Kerry for weak action in Syria.
Putin is outspoken, to be sure; but the name calling has hardly been one-directional. In a recent press conference, Obama criticized Putin's characteristic slouch and said that he's like "a bored kid in the back of the classroom." An anonymous Kremlin official, quoted in the New York Times, reported that Putin was "infuriated" by the President's maladroit remark.
All of this makes me really angry.
Not angry at the Russian president for his frank pronouncements regarding American politicians.
Rather, I am angry that America's pompous leader should have so squandered the tentative post-Cold War relationship which was begun in 1971, during the détente period under the leadership of Presidents Richard Nixon and Gerald Ford, and which was further developed during later presidencies. I am angry that America appears to be losing her moral authority, her noble vision, her principled leadership.
Mr. President, in case you've forgotten, you work for me—and for all of the American people. A majority of your citizen-employers, the American people, value the cooperative relationship with other superpowers that your less strident predecessors nurtured. We DO NOT want you to launch military airstrikes against the Assad regime. We don't believe your objective is clearly defined, and we don't believe killing innocent civilians by indiscriminate air attacks conveys the "message" you hope to send.
Political relationships are fostered, not by derision, but by generous cooperation and diplomatic speech. Mr. President, you have demonstrated here at home, and now abroad, that you can't pass up the opportunity to throw a little mud toward your opponents. We don't want to see you scuffling like the class bully on the world stage; rather, we expect your skilled diplomacy to persuade our opponents to seek justice.
We expect you to generate a spirit of cooperative partnership, inspiring Russian leaders to join with us to seek the common good. Wipe that smart-ass sneer off your face, and get to work.