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Influenza A Virus Studies in a Mouse Model of Infection
1Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry
Immunology and Infection
1Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry
1Departamento de Desarrollo Biotecnológico, Universidad de la República, 2Present Affiliation: Trinity Biomedical Science Institute, Trinity College Dublin
1Antibacterial Discovery Performance Unit, GlaxoSmithKline
1Department Genetics of Microorganisms, Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald
1Pneumococcal Research, Murdoch Childrens Research Institute, 2Allergy & Immune Disorders, Murdoch Childrens Research Institute, 3Department of Otolaryngology, The University of Melbourne, 4Department of Microbiology & Immunology at the Peter Doherty Institute for Infection & Immunity, The University of Melbourne
1Institute of Molecular Pathogenesis, Friedrich-Loeffler-Institut
1Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud university medical center
1Department of Molecular and Biomedical Sciences, University of Maine, 2Graduate School of Biomedical Sciences and Engineering, University of Maine, 3School of Biology and Ecology, University of Maine, 4Division of Intramural Research, Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, NIH, 5Department of Chemical and Biological Engineering, University of Maine
1Department of Pediatrics, Division of Host-Microbe Systems & Therapeutics, University of California San Diego School of Medicine, 2Department of Biology and Center for Microbial Sciences, San Diego State University
1Department of Biology, San Diego State University, 2DOE Joint Genome Institute, 3Department of Molecular, Cellular and Developmental Biology, University of Colorado, 4Department of Pediatrics, School of Medicine, University of Colorado
Source: Kay Stewart, RVT, RLATG, CMAR; Valerie A. Schroeder, RVT, RLATG. University of Notre Dame, IN
Many animal experiments rely on final data collection time points that are gathered from the harvesting and testing of organs and tissues. The use of appropriate methods for the collection of organs and tissues can impact the quality of the samples and the analysis of the data that is gleaned for the testing of the tissues. The method of euthanasia of the animal can also impact the quality of the samples. This manuscript will outline proper necropsy techniques for rats.…
1School of Pharmacy, University College London, 2Mucin Biology Group, University of Gothenburg
1Department of Chinese Medicine, Taipei Medical University Hospital, 2Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, 3Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, 4Division of Hematology and Oncology, Department of Internal Medicine, Taipei Medical University Hospital, 5Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, 6Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University
1Department of Pediatrics, Harvard Medical School, 2Department of Pediatric Gastroenterology, MGH for Children, 3Mucosal Immunology and Biology Research Center, Massachusetts General Hospital
1Biological Systems Research, Philip Morris International R&D, Philip Morris Products S.A.
1Department of Radiology, Case Western Reserve University, 2Department of Pediatrics, Case Western Reserve University, 3Department of Urology, Case Western Reserve University, 4Department of Biomedical Engineering, Case Western Reserve University
1EPSRC Proteus Hub, MRC Centre of Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, 2School of Chemistry, EaStChem, University of Edinburgh
1UGent Center for Medical Biotechnology, VIB, 2Department of Biomedical Molecular Biology, Ghent University (UGent)
1Center for Environmental Medicine, Asthma, and Lung Biology, The University of North Carolina at Chapel Hill, 2Department of Pediatrics, The University of North Carolina at Chapel Hill, 3Pulmonary Diseases and Critical Care, The University of North Carolina at Chapel Hill, 4Curriculum in Toxicology, The University of North Carolina at Chapel Hill
1Louisiana State University Health Sciences Center
1Infections and Cystic Fibrosis Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, 2Italian Cystic Fibrosis Research Foundation
1Department of Osteopathic Manipulative Medicine, New York Institute of Technology College of Osteopathic Medicine
1Institute of Infection and Global Health, University of Liverpool, 2NIHR Biomedical Research Centre in Microbial Disease, University of Liverpool
1Research Group Immune Regulation, Helmholtz Centre for Infection Research, 2Research Group Infection Immunology, Institute of Medical Microbiology, Otto-von-Guericke University, 3Department of Experimental Immunology, Helmholtz Centre for Infection Research
1Department of Veterinary Preventive Medicine, The Ohio State University
1Hans Berger Department of Neurology, Jena University Hospital, 2Immunology, Leibniz Institute for Age Research, Fritz Lipmann Institute, Jena, 3Institute of Diagnostic and Interventional Radiology, Medical Physics Group, Jena University Hospital
1Department of Medicine, Solna and CMM, Respiratory Medicine Unit, Karolinska Institutet, 2Safety Science, Global Regulator Affairs & Patient Safety, AstraZeneca Global Medicines Development
1Department of Laboratory Medicine, University of California, San Francisco, 2Division of Infectious Diseases, University of California, San Francisco
1Baylor Institute for Immunology Research, Baylor Research Institute
1Department of Biology, Indiana University of Pennsylvania
1Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, 2California NanoSystems
1Division of Basic Medical Sciences, Mercer University School of Medicine
1Director of Pulmonary Special Procedures and the Lung Cancer Center, Virginia Hospital Center, 2Chief, Division of Pulmonary Critical Care and Sleep Medicine, Virginia Hospital Center
1Department of Pharmacology, University of Illinois College of Medicine, University of Illinois at Chicago, 2Section of Pulmonary and Critical Care Medicine, Atlanta VAMC, Emory University, 3Biologic Resources Lab, University of Illinois at Chicago
1Recherche translationnelle: relations hôtepathogènes, Université Lille
1Department of Pathology, Stanford University School of Medicine, 2Department of Microbiology & Immunology, Stanford University School of Medicine
1Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health
1Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, 2Clinical Research Laboratory, 81st Medical Group, Keesler Air Force Base
1Pathobiological Sciences, Louisiana State University
1CRCHUM - Research center, Centre Hospitalier de l'Université de Montréal, Université de Montréal, 2Department of Biochemistry and Molecular Medicine, Université de Montréal, 3Faculty of Medicine, Université de Montréal
1Cardiovascular Division, King's College London BHF Centre
1Department of Medicine, General Pathology Division, Cystic Fibrosis Translational Research Laboratory "D. Lissandrini", University of Verona, 2Corporate Preclinical R&D, Chiesi Farmaceutici S.p.A., 3Department of Diagnostic and Public Health, Microbiology Division, University of Verona, 4Dipartimento di Scienze Medico-Veterinarie, University of Parma, 5Department of Biomedical Biotechnological and Translational Sciences, University of Parma, 6Department of Computer Science, University of Verona, 7Department of Neurological, Biomedical and Movement Sciences, University of Verona, 8Cystic Fibrosis Regional Center (CFC), AOUI Verona
1Institute for Molecular and Clinical Immunology, Otto-von-Guericke University Magdeburg, 2Department of Immunoregulation, Helmholtz Center for Infection Research
1Department of Microbiology and Immunology, University of Melbourne, 2Laboratory of Pediatric Infectious Diseases, Radboud University Nijmegen Medical Centre, 3The Centre for Dynamic Imaging, The Walter and Eliza Hall Institute for Medical Research
1Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine
1Neonatology and Pulmonary Biology-Perinatal Institute, Cincinnati Children's Hospital Medical Center, 2University of Cincinnati, College of Medicine
1Department of Pediatrics, University of Tennessee Health Science Center, 2Department of Infectious Diseases, St. Jude Children's Research Hospital, 3Department of Veterinary and Microbiological Sciences, North Dakota State University, Fargo
1Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern
1Department of Molecular and Biomedical Sciences, University of Maine, 2Graduate School of Biomedical Sciences and Engineering, University of Maine
1Neurorestoration, Wolfson Centre for Age-Related Diseases, King's College London, 2Department of Neuroscience, Baylor College of Medicine


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Bethlehem Auto Svc
Review for Bethlehem Auto Svc
GUOPING F. on 07/30/2015
"Excellent service"
I had the engine light on for my Honda CR-V. John explained to me in details what went wrong, as usual. His service is always in high quality, and he does business in a very honest way.
Vehicle: Honda CR-V
Service Date: 07/29/2015
Review Created: 07/30/2015 04:52 AM

subset: commoncrawl


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Button down shirts; Collared shirts; Hats; Hooded pullovers; Hooded sweatshirts; Jackets; Polo shirts; Short-sleeved or long-sleeved t-shirts; Socks; Sweat shirts; T-shirts
Business in Alameda, CA


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Owners have alternate plans if no casino built at racecourse
Tracking Suffolk's future
Credit: Christopher Evans
With East Boston's nay vote on a resort casino, the future of the 116 Eastie acres that are home to the Suffolk Downs racetrack is back in flux — and the property could see new development in another direction.
Sterling Suffolk Racecourse's new preferred plan is to build its casino entirely on land in Revere and preserve the racetrack as a separate East Boston operation, according to Chief Operating Officer Chip Tuttle. But it has three alternate plans for mixed-use projects encompassing both sites should the casino and racetrack prove unfeasible.
"They're based on the reality that this is 161 acres of very attractive development opportunity that could be a massive mixed-use (project)," Tuttle said, referring to the combined East Boston and Revere site. "There's a lot of options."
One mixed-use alternative is heavier on office space: a 3.8-million square-foot development of 15 buildings with 1.28 million square feet of retail, 1.49 million square feet of office space, 1,031 residential units and 11,978 parking spaces.
The other is more retail-dependent: a 2.8-million square-foot project of 16 buildings with 1.64 million square feet of retail, 147,000 square feet of office space, 900 residential units and 8,077 parking spaces. A third plan combines light-industrial, airport-dependent uses with mixed-use buildings.
Former Boston mayoral candidate Bill Walczak, who's advocated for a new innovation district on the Suffolk Downs site, said a master plan first should be developed to determine what industries to serve.
Meanwhile, uncertainty about a casino and the racetrack is likely to stall development investment around Suffolk Downs, said David Begelfer of NAIOP Massachusetts, a commercial real estate development trade group. "With uncertainty, there's a lot of risk, and that scares away money," he said.
But that should have no effect on the East Boston waterfront, where there are nine pipeline projects, including Roseland Property's $67 million, 176-unit Portside at Pier One, Begelfer said. "You're really talking about users there who most likely will be working downtown. The waterfront ... is very strong."
But East Boston Chamber of Commerce President Diane Modica said she had hoped an East Boston casino would help jumpstart other waterfront projects still trying to secure financing. "We had hoped that … it) would inspire investor confidence to a new level," she said.


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November 14, 2014 is World Diabetes Day, a day dedicated to raising awareness for the global issue of diabetes. Diabetes is a serious disease of the pancreas, and there are three types.
Type 1
Also known previously as juvenile onset diabetes, Type 1 diabetes is generally diagnosed at a very young age. For this type of diabetes, the pancreas does not produce insulin at all.
Type 2
Type 2 diabetes occurs when the body either produces inadequate insulin, or the body is unable to utilize the insulin produced.
Gestational diabetes
This type of diabetes occurs in approximately one in 25 pregnancies across the globe. Although generally resolved post-partum, women who experience gestational diabetes are more prone to developing Type 2 diabetes later in life, as are their children.
Global diabetes statistics
Some statistics about diabetes across the globe:
- China has the most diagnosed cases of diabetes, with 98.4 million cases in people between the ages of 20 and 79.
- Over 37% of the population of Tokelau has diabetes. That is nearly four out of every ten people.
- There were 382 million people living with diabetes in 2013. That number is projected to rise to 592 million people by the year 2035, an increase of 55%.
- North America will spend 263 billion annually on health costs related to diabetes. The proportion of deaths related to diabetes for people under 60 is 38%.
- European countries will spend 147 billion annually, and their proportion of diabetes-related deaths for people under 60 is 50%.
- The Middle East and North Africa have the highest percentage of the population living with diabetes at just under 12%.
Worldwide, 46% of diabetes cases go undiagnosed, so it is important to raise awareness and recognize the signs and symptoms of this disease. For Type 1 diabetes, symptoms usually come on swiftly and are extreme, while Type 2 symptoms may occur gradually over time.
Some signs to watch out for include:
- Excessive thirst and frequent urination
- Extreme fatigue
- Blurry vision
- Numbness or tingling in the extremities (hands and feet)
- Increased infections
- Wounds that heal more slowly than usual
- Weight loss not associated with a change in diet
- Increased appetite
- Difficulty staying focused
- Loss of interest
Diabetes risk factors
Risk factors are different for different people. Although heredity plays a large part in Type 1 diabetes, there are other risks factors for Type 2, some of which can be controlled.
These include:
- Lack of physical activity. People who are inactive and do not get a minimum amount of physical exercise daily are at an increased risk.
- Unhealthy diet. Diets high in fat, sugar, and processed foods increase the chances of developing diabetes.
- Obesity. Obesity is the number one risk factor for developing diabetes. With a few notable exceptions, people who are obese tend to have a lower level of physical activity and an unhealthy diet.
- Age. The older you are, the more likely you are to develop Type 2 diabetes.
- High blood pressure. High blood pressure can be caused by a number of different conditions, which can then lead to diabetes.
- Ethnicity. People of Southeast Asian, Middle Eastern, African, and Latino descent have a higher incidence of diabetes than their European counterparts.
Diabetes prevention
Type 1 diabetes cannot be prevented at this time, but Type 2 diabetes can be prevented or the progression of the disease slowed if corrective action is taken.
To reduce your chances of developing diabetes, follow these simple guidelines:
- Reduce your sitting time. Getting up and moving around every 20 minutes or so increases blood flow to the brain and muscles and generally improves circulation. Simply stretching at your desk or walking around during commercial breaks when watching TV can reverse the effects of too much sitting.
- Increase exercise. It doesn't matter where you start an exercise plan as long as you start one. Walking for one hour three times a week can reduce the progression of diabetes by up to 58%, and 30 minutes of any type of daily exercise (walking, biking, swimming, etc.) reduces the risk of developing Type 2 diabetes by 40%. Start an exercise plan by walking five minutes a day, even if that is all you can do, and gradually add on to that until you are walking for at least 30 minutes daily.
- Fix your diet. Malnutrition or inadequate food sources are a problem that is at the root of diabetes around the world. Some blame urbanization and the accompanying food deserts that exist in city environments for the shabby state of nutrition in city dwellers. In some cases, it may be possible to remedy this with CSA (community-supported agriculture) deliveries. In others, it may be harder to remedy than simply telling people to eat better. Whatever the case may be, adding as many fresh fruits and vegetable to your diet, along with whole grains and lean proteins is a step in the right direction. Eliminate sugar and processed foods as much as possibly and substitute in healthy snacks and meals when possible. Global poverty, regional conflicts, and food shortages due to weather make this step more difficult for some areas of the world, but it is a necessary change to help curb diabetes.
- Get enough sleep, but not too much. Sleeping less than six hours a night or more than nine hours are both linked with increased risk of Type 2 diabetes. Sleeping less interferes with the way the body processes food, and sleeping more can indicate depression, another risk factor for diabetes. Develop good sleeping habits and stick with them.
- Stop smoking. In addition to increasing your cardiovascular healthy instantly, stopping smoking is an excellent way to reduce your risk of developing diabetes. Smoking is associated with weight gain in the abdomen and high blood pressure, both of which are risk factors for Type 2 diabetes.
Diabetes affects less-developed nations more deeply than more-developed first-world countries. Extreme poverty and all of its attendant problems (food and water shortages, lack of proper medical personnel and supplies, conflict and war) make diabetes a problem that is difficult to address.
It is easy to tell someone to eat better food when first-world nations have grocery stores readily at hand. For a developing country with no reliable access to fresh food, the chances of making substantive changes quickly are slim.
World Diabetes Day
World Diabetes Day is organized by the International Diabetes Foundation (IDF), and their focus is:
- Advocacy
- Awareness
- Education
- Epidemiology and Prevention
- Essential Care
- Guidelines
- Health Economics
- Translational Research
- Women and diabetes
By raising awareness on a global level with World Diabetes Day, the IDF then works on the community level to implement strategies and policies that help combat diabetes at all levels of development. You can get involved and do your part to help IDF in their mission by organizing or participating in activities near you.
To find out your risk for developing Type 2 diabetes, fill out this quick questionnaire.
Image from the International Diabetes Foundation
Weekly updates on conditions, treatments, and news about everything happening inside pain medicine.


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Sabbath Thoughts: My Sabbath Tears
3 months ago
CONGRATS on finishing nursing school! I come from a long line of nurses (I am not one), but I know that it is great work! Awww and you met Mr. Right - alright now! And thanks for visiting the 5Spot!
Congratulations & Continued Success!!! & Your locs are lovely!!! Take care!
Thanks Rum Punch! I LOVE the blog!
Thanks Urban...I am guessing your blog is under construction??? I am following you though!


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Learning Resources - Anglegs Student Set
AngLegs® Student Set
Explore plane geometry with AngLegs®! Ideal for hands-on activities that teach shape identification, spatial reasoning, basic measurement, perimeter and area, locating center points and much more. Measure shapes by attaching them to 2 transparent protractors included in each set. Snap-together plastic pieces in 6 different lengths feature color-coding. Sets also include 15 double-sided Activity Cards. Aligned with NCTM Standards. Great for individual, center or small-group use. Pieces measure 2"L to 5¾"L. Grades K+
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Be a Trusted Resource
Let's close out the Brand Propheteers series with an action tip for you today.
A while back, I wrote a post asking Who Drives Better, Men or Women? There are many studies that show women are traditionally better drivers of word-of-mouth.
This Mother's Day weekend, think about your Mom. She was always recommending a doctor, a new snack food, a restaurant where babies are welcome, or a shop where the salespeople never tire of answering her questions in plain English without making her feel pressured to buy.
Times are changing, and men are catching on to the amazing power of word-of-mouth. It's time to smash the tradition! Ladies and gentlemen, shy and bold, business owners and consumers: Get out and recommend one product or service today. Open your ears, listen for opportunities, and you can make someone else's day better. Focus more on others than on yourself and your shyness will recede. You'll hear chances to make recommendations all around you, with friends, customers, and strangers.
Make an introduction, like Keith Ferrazzi. Suggest a better match for your customer, like Kris Kringle in Miracle on 34th Street. Rave about a company you purchase from, or a blog you read (Harry and his commenters got a great discussion going about customer service going at Men With Pens this week), and become one of their Propheteers.
Give generously, and that generosity will come back to you. As you give, your friends, family, colleagues, and customers will remember your help, and the ranks of your own Propheteers will grow.
Bonus: Make listening and giving a habit. After you get out and rave about somebody today, do it again tomorrow. Soon you'll be known not just as a great businessperson, but also as a facilitator, and a trusted resource.
Grow and be well,
Kelly Erickson
3 Responses to "Tip of the Week: Mother's Day Special – The WoMamas and the WoPapas"
Damn. You changed your picture and… damn. You look good, Kelly. (I refuse to retaliate by looking good on my own blog in the same way, but I think every woman needs a smile and that'll bring you two, if I'm good at my job.)
What you mention in your post is very smart – refer GOOD places, resources and services, and you'll increase your own credibility. That's very smart indeed.
(Why didn't I think of that?)
*sticks post-it note to computer to remind to come visit and check for further comments…*
@ Kelly – I have many post its. They generally get in the way of my screen and annoy me, so I rip them off, plunk them somewhere else and…
I do read, each time a post comes up. But if you want continual presence, you have to put the functionality to make it happen.
Now, to go back to Tei's post and see what I missed.


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Islands of snow and structures set the scenes for Almost, Maine.
The Tech Theatre Company took us to Maine in their latest production, but it all looked eerily familiar.
Almost, Maine was a village with snowmobiles, a friendly tavern, northern lights, camping, ice fishing, plenty of snow, and, in the end, we discover that everybody knows everybody else.
There were many metaphors for love and loss along the way on a small-town Friday night.
A young couple has a dalliance under the northern lights and shooting stars. Another woman camps out in someone's yard, trying to make amends and mend a broken heart. Another couple is splitting up in the Moose Patty Cafe, but they both land on their feet.
Apartment dwellers get entangled in a laundry room and ruminate on pain and love and painful love. Young lovers seem to be splitting up, with lots of literal baggage being returned, only to be united and engaged.
Two ice fisherman fall in love, literally on the ice, and by the end of the play must crawl off the set. Another couple argues about a missing boot and a skating date that goes bad. (The boot appears out of the sky.)
A woman named Hope returns to Almost to finally say "yes" to a marriage proposal (too late?). And, finally, a snowmobiling couple finds romance after a trail ride and the tomboy's epiphany.
The set was the usual astounding assembly: islands of snow set off each scene. Wooden cabins, bar, houses, and apartments surrounded an icy lake (shaped like a heart). And a Polaris and an Arctic Cat graced stage right.
The northern lights ran through the room. Lighting brought us from scene to scene as did the space music that was also a nice intro, transition, and finale.
What was revealed at the end was the power of love, up-north style, and the talent of our students, faculty, staff, and community, who never disappoint on the other side of campus.
Snowfall Totals
Total to date: 118.5"
On the ground: 26"
In the last week: 18.5"
Total last year: 148"
On the ground: 18"


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We recommend upgrading to the latest Internet Explorer, Google Chrome, or Firefox.
If you are using IE 9 or later, make sure you turn off "Compatibility View".
Handpicked brands for you
#GoPro Featured Photographer + Family member: @robbiecrawford About the shot: This photo is of GoPro Athlete @whoisjob who is one of the most fun surfers on the planet to shoot with because he'll go on any wave that comes his way no matter how nuts....


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|12 Mar 2014
Win 7 Ultimate 64 bit
If i am not mistaken FileMonkey is not on the list.
it a bulk file renaming utility. very easy to use.
Attachment 310116
|My System Specs
|12 Mar 2014
Windows 7 Ultimate X64 SP1
If i am not mistaken FileMonkey is not on the list.
it a bulk file renaming utility. very easy to use.
Attachment 310116
|My System Specs
|13 Mar 2014
Microsoft Windows 7 Home Premium 64-bit Service Pack 1
I's difficult to find free software without the optional bundled software these days.
|My System Specs
|13 Mar 2014
Umm Not sure What they bundled with it
i am using ver10.91 and it dint installed anything else
besides application.
Can anyone check it?
|My System Specs
|21 Mar 2014
Windows 7 Pro x64 (1), Win7 Pro X64 (2)
Just a note that FreeCommander (which has been at version 2009.02b for many years) has recently released a new "FreeCommanderXE 2014" version.
Much enhanced GUI functionality (e.g. tabs, Favorites, flexible toolbar customization, etc.) so it looks more sleek, modern and up-to-date. And navigation is much slicker, including "Desktop" and "Network" as drives, along with choice of "Desktop", "Computer", or "Drive" as top-level in Tree view.
Don't know that there is much functional capability difference, as even the 2009 version was always a SUPERB substitute for Explorer and all things we wished had been in Explorer.
NOTE: the new INI file is incompatible with the old INI file, so you must re-customize the new program after installation from scratch. You can't just copy the old INI file over. It'll take a bit of experimentation to work through the new Settings dialog and learn where all the new options are located. Be sure to read the README that pops up after installation, to learn about the basic differences in this new version.
|My System Specs
|21 Mar 2014
I've used FC for a long time. But it's my understanding not everything in XE is implemented yet. One example is FTP client. Even though I have XE when I use FC it's the previous version. I've set it up so many times with extenal programs etc. that I think I'm worn out. But the built in renamer is a real gem. Nice middle ground between Explorer and something very complex like Bulk Rename Utility.
|My System Specs
|23 Mar 2014
FAT Sorter v1.0.4
FAT Sorter v1.0.4 is a free program to Sort the File Allocation Table of a USB drive.
The main reason for doing this is to force your MP3 player to play the files in order. It's simple to use and quick.
|My System Specs
|07 Apr 2014
Windows 7 Ultimate x64 SP1
Thank you for EasyBCD and MBR Backup
|My System Specs
|23 Apr 2014
Windows 7 Professional 32-bit/Windows 8 64-bit/Win7 Pro64-bit
Remember, you don't need all of them and should only get the ones you really need, zap9x.
|My System Specs
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Try this software out, it works like a charm on Windows 7, very easy to use as well.... Dream Desktop - New Wallpapers Loads of very nice images.
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Free Partition Software. Great Offer
Giveaway of the Day - free licensed software daily. Today: Partition Manager 10.0 Personal (English) - Special offer for our GAOTD users ? Partitioning for Windows 7 and 64-bit version support!We want to thank you for ... Check this out gang. This is a great offer.
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Stock Graphic >> Illustration - Plumber Wrench Plunger Front Shield 137090 by patrimonio @ CreativeMarket
File Size: 68.77 KB; Vector: Yes.
Illustration of a plumber holding monkey wrench raised high and plunger viewed from front set inside shield crest done in cartoon style on isolated background.
The zipped file includes editable vector EPS, hi-res JPG and PNG image
Keywords: plumber, monkey wrench, wrench, shoulder, holding, plunger, raise, front, tradesman, repairman, worker, tool, handyman, isolated, man, male, artwork, cartoon, illustration, graphic.


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Hotel de la Tulipe
Select your stay dates to check availability
Hotel de la Tulipe
About the hotel
Property Location
With a stay at Hotel de la Tulipe in Paris (Eiffel Tower - Orsay Museum), you'll be minutes from American University of Paris and Pont des Invalides. This hotel is close to Eiffel Tower and Arc de Triomphe.
Make yourself at home in one of the 21 guestrooms featuring refrigerators and minibars. Complimentary wireless Internet access keeps you connected, and flat-screen televisions are provided for your entertainment. Private bathrooms with bathtubs or showers feature complimentary toiletries and hair dryers. Conveniences include safes and desks, and housekeeping is provided daily.
Rec, Spa, Premium Amenities
Take in the views from a garden and make use of amenities such as complimentary wireless Internet access and concierge services. Additional features include babysitting/childcare (surcharge) and tour/ticket assistance.
Take advantage of the hotel's 24-hour room service.
Business, Other Amenities
Featured amenities include complimentary newspapers in the lobby, luggage storage, and a library. Self parking (subject to charges) is available onsite.
Hotel Facilities
- Total number of rooms - 21
- Free WiFi
- Number of buildings/towers - 3
- Self parking (surcharge)
- Free newspapers in lobby
- Tours/ticket assistance
- Breakfast available (surcharge)
- Babysitting or childcare (surcharge)
- Library
- Safe-deposit box at front desk
- Concierge services
- Luggage storage
- Garden
- Number of floors - 3
- Year Built 1740
Room Facilities
- In-room safe
- Room service (24 hours)
- Free cribs/infant beds
- Free toiletries
- Desk
- Private bathroom
- Rollaway/extra beds available
- Daily housekeeping
- Free WiFi
- Hair dryer (on request)
- Free newspaper
- Refrigerator
- Iron/ironing board (on request)
- Flat-panel TV
- Bathtub or shower
- Minibar
Hotel Policy
National Rating
This hotel has received its official star rating from the French Tourism Development Agency, ATOUT France.
Know Before You Go
- This property allows pets in specific rooms only (surcharges apply and can be found in the Fees section). Guests can request one of these rooms by contacting the property directly, using the contact information on the booking confirmation.
The following fees and deposits are charged by the property at time of service, check-in, or check-out.
- Fee for continental breakfast: EUR 11.00 per person (approximately)
- Self parking fee: EUR 26.00 per night
- Pet fee: EUR 20 per pet, per night
- Rollaway bed fee: EUR 15.00 per night
The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.
Mandatory Fees and Taxes
You'll be asked to pay the following charges at the hotel:
- A tax is imposed by the city: EUR 1.65 per person, per night
We have included all charges provided to us by the property. However, charges can vary, for example, based on length of stay or the room you book.Show all hotel policy Show less hotel policy


text: I am trying to develop an application in .NET using WPF and using 32feet productions software solution. I want to be able to transmit an image from Windows 7 to Android using OBEX, there are several OBEX clients such as Astro and Medieval Bluetooth file transfer which i have used but nothing seems to work. My program tries to simplify the pairing process by specifying a 4 digit pin such as 0000 so that when we initiate a file transfer to the bluetooth address the user on the other hand just needs to push in 0000. I also seem to notice that the file transfer ftp seems to choose different ports each time, is there a way to predict this or keep this static? Last question, is there a way to send a file to Android without pairing? We try obex push but it doesnt seem to take it.


text:
This is a discussion board for all users and developers of ImageJ and Fiji.
The purpose of this ImageJ forum is to:
Any question or discussion regarding ImageJ or Fiji has a place here. The community is diverse, helpful and attentive. We aim to facilitate ease of communication through this ImageJ forum.
The ImageJ forum was built using Discourse. If you have never used a Discourse-based forum before you may be interested in some of the great features they have made available:
Also, there are several guides available:
Looks nice! Cannot wait until this place is full of life!
Great! Congratulations guys for making this real.
I believe the email issues are finally resolved, as of 10 hours ago. We'll test more tomorrow and if all looks well, announce it to the lists.
This is great
This is great! Congratulations !
fantastic! thank you @ctrueden for making this happen!!!
Wow, I really think discourse was a great decision @ctrueden!
I'm wondering whether the requirements for trust levels are set to the discourse defaults?
Or, in other words, what do I need to do to be able to edit posts from other users?
I locked you to Level 3 "Regular" and also made you a moderator. Maybe that is sufficient? Give it a shot.
Ah, that does the job! Thanks a lot @ctrueden!
A post was split to a new topic: Particle measurements in mircofluidics
This sounds great!!! And thank you for making this happen.


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Learn the unique in-camera effect called the Dolly Zoom, including some of the concepts and principles that govern the visual effect as well as some practical tips on how to achieve the effect yourself. Film examples used in this course are "Vertigo", "Jaws" and "Goodfellas".
John P. Hess
Course Instructor
- Login to Start CourseIntro to the Dolly Zoom
- Login to Start CourseDolly Zoom in Production
- Login to Start CourseDigging Deeper into Perspective Distortion
- Login to Start CourseUnderstanding Zoom Lenses
- Login to Start CourseThe Basics of Dollies
- Login to Start CourseCOURSE QUIZ – Mastering the Art of Dolly Zoom
- Login to Start CourseLAB ASSIGNMENT – Making the Dolly Zoom


text:
Loco Sixo
B-tier · PDGA sanctioned singles tournament
About this tournament
- 36 holes: 18 Chuck D. Memorial / 18 Picnic
- $500 added cash for MPO division
- $150 added cash for AM1 division
- $100 added cash for AM2 division
- $50 added cash for AM3 division
- $450 in added cash & prizes for CTPs
- 8 MDGO State Championship Berths will be awarded
- First 90 Ams to pay entry fee will receive custom hot stamp player's pack disc
Choice of:
- KC Pro Aviars
- CFR Glow Teebirds
- CFR Glow Destroyers
- Champ Katanas
- First place trophies for MPO, AM1, AM2, AM3
- $101 All Division CTP, $5 Ace Pool, 50/50 CTPs, Tons of Merch CTPs
- Collectible disc raffle
- Lunch will be available for order from B Line Bar & Grill
$5 will get you half a large pepperoni or cheese pizza
- Pre reg by leaving name/division/PDGA # or email in the talk section:
- Payments can be day of or through Paypal to: [email redacted] less
Matt Zajechowski April 11, 2011 at 10:07pm
Ignce #28409, senior grandmaster junior girls please
Mike Fortunato April 11, 2011 at 9:44pm
Scott forgot to mention that this litter must be collected without disrupting the flow of play. We cant have people searching for trash and holding everyone up.
Scott White April 11, 2011 at 8:33pm
My sponsorship deal is as such:
"The Scott White Keep it Clean, Butts are Litter" award will go to:
Whomever picks up the most cigarette butts and bottle caps during the course of the tournament will have his or her entry fee paid in full. (base entry not including extra fees and options). The only caveat is: no cheating! You must find the caps and butts at Independence Lake County Park on the day of the tournament. The winner will posses the highest sum total # of butts + caps.
Troy Meadows April 11, 2011 at 8:29pm
If i can't come out to sat leagues, can i mail you a check for pre-reg?
Troy Meadows April 11, 2011 at 8:23pm
Troy Meadows #34101 am2
lyle downing April 11, 2011 at 3:13pm
lyle downing 42481 am2
peter kunoff April 10, 2011 at 6:35pm
what molds will be having this years loco stamp? I already know about (and got) the glow firebirds...
Ryan Duffy April 10, 2011 at 6:08pm
ryan duffy am1 44658
Joe Willyard April 10, 2011 at 5:34am
Joe Willyard April 10, 2011 at 5:33am
Joe Willyard #47467
Mike Fortunato April 8, 2011 at 6:59pm
Paypal is being greedy.
Matt Zajechowski April 8, 2011 at 6:56pm
Please to explain these paypal shenanigans tdogg?
Mike Fortunato April 8, 2011 at 6:53pm
*** Paid pre-reg through DGS will be ending on Sunday evening due to Paypal shenanigans. After Sunday you can still post your name/number here in the talk section to stake your claim.***
Mike Fortunato April 7, 2011 at 6:18pm
Sarah, you don't need to reg with cash, but it will save you $5 if you do.
Sarah DeMar April 7, 2011 at 4:51pm
Sarah DeMar #25166, FPO. Need to reg w/ cash, will try to come to leagues (Sat noon?) on the 16th.
Joe Gabris April 6, 2011 at 6:49pm
Joe Gabris #20515
Ian Kuehn April 4, 2011 at 11:39pm
Ian Kuehn AM1 PDGA #41287 and Ricky Wysocki Open PDGA# 38008. Thanks!!!
Steve Blink April 4, 2011 at 12:45am
Steve Blink Am 2
Mike Fortunato April 2, 2011 at 5:00am
Sweet. Thanks Tony.


text:
Thank you for your interest in joining the CACBT! In order to
get the most out of your membership, please complete the below as fully and accurately
as possible. Thank you.
* Required
***Please click "Submit" only once. It may take several moments to process your
payment. Clicking on "Submit" more than once may result in multiple payments being


text:
Cartel associates extradited to San Antonio
Four men extradited from MexicoOctober 1, 2015 Updated: October 1, 2015 9:38pm
Photo: John Davenport /San Antonio Express-News
Under tight security, four accused associates of the Juárez Cartel were taken to the federal courthouse in San Antonio on Thursday after being delivered from a prison in Mexico where they've been held for several years.
To continue reading this story, you will need to be a digital subscriber to ExpressNews.com.
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May 21, 2010
Should Congress Reimpose Glass-Steagall?
Last night, the Senate passed its financial reform bill – "The Restoring American Financial Stability Act" – by a vote of 59 to 39, with two Democrats voting against the bill and four Republicans voting for it. The next step for the legislation as it makes its way to President Obama's desk is a conference committee, in which the freshly passed Senate bill will be reconciled with the House bill – the "Wall Street Reform and Consumer Protection Act" – passed on December 11th of last year.
In a May 13th interview with Bloomberg News, Rep. Barney Frank (D-MA), the chairman of the House Financial Services Committee, stated that the conference would likely "strengthen" the Senate bill, noting that public anger at financial institutions had only intensified since passage of the House bill. That same day, House Speaker Nancy Pelosi (D-CA) said that House Democrats were looking forward to Senate completion of the bill "so that we can go to conference and send a very clear message: never again will recklessness on Wall Street cause joblessness on Main Street."
Among the more draconian "reforms" debated by both the House and Senate in recent months, and perhaps again in the upcoming conference, is to repeal the Gramm-Leach-Bliley Financial Modernization Act of 1999 ("GLBA") as a means of reimposing Depression-era "Glass-Steagall" restrictions between commercial banking and non-bank financial activities. Such efforts are misguided and, if enacted as part of the final legislation, would severely undermine the effectiveness and competitiveness of American financial institutions, with very negative consequences for the stability of the U.S. financial system and, therefore, the productive capacity of the U.S. economy.
The Glass-Steagall provisions of the Banking Act of 1933 legally separated commercial banking and investment banking. As a result, "universal banks" engaged in both commercial lending and the underwriting of securities were forced to divest of one of those businesses. JP Morgan, for example, spun off its securities business, which became Morgan Stanley.
GLBA repealed Glass-Steagall by permitting well-managed and well-capitalized financial institutions to engage in a diversified range of financially related activities, including commercial banking, securities dealing and underwriting, insurance agency and underwriting activities, and merchant banking by way of separate subsidiaries affiliated under a structure called a "financial holding company" ("FHC"). Congress' intent in passing GLBA was to enable U.S. financial services firms competing in an increasingly global and competitive marketplace to organize themselves in ways more responsive to customer needs and shareholder priorities.
A proper policy response to the recent financial crisis requires an accurate diagnosis of the factors that actually contributed to the crisis. GLBA had nothing to do with the crisis. Proposals to repeal GLBA make the classic logical error of equating association with causation – simply because GLBA proceeded the financial crisis does not mean that GLBA caused the crisis.
More than 550 FHCs had been formed by the onset of the recent crisis. Only two – Wachovia and Citigroup – were nearly ruined by the crisis. Indeed, most of the notorious names of the crisis – Bear Stearns, Lehman Brothers, Merrill Lynch, Countrywide, Washington Mutual, IndyMac, and AIG – were not FHCs. Bear, Lehman, and Merrill were investment banks; Countrywide, WaMu, and IndyMac were thifts; AIG is an insurance company.
Of the five largest FHCs, three of them – Wells Fargo, Bank of America, and JPMorgan Chase – not only weathered the crisis, but served as instruments of stabilization and recovery by absorbing many of the failing institutions. JPMorgan Chase absorbed Bear Stearns and WaMu; Bank of America absorbed Countrywide and Merrill Lynch; Wells Fargo absorbed Wachovia.
Even Wachovia's near-failure was not due to errors in its principal activities or management, but entirely to its ill-timed purchase, in March of 2006, of Golden West Bancorp – an OTS-supervised thrift and the largest subprime mortgage underwriter in California.
In an October 2009 report, "Deregulation and the Financial Crisis," Peter Wallison of the American Enterprise Institute, concluded that "there is strong evidence that, despite heavy regulation, many of the banks that got into trouble did so by failing to act prudently in their investment or lending activities – in other words, in their capacity as banks – and not because they engaged in securities trading or were affiliated with investment banks that were underwriting and dealing in securities."
It should also be noted that had Glass-Steagall restrictions been in place during the recent crisis, the resolution of failing non-FHCs (Bear, Lehman, Merrill, etc.) by absorbing them into large FHCs would not have been legal. Reinstating Glass-Steagall would remove a major option for resolving failing institutions and, therefore, would leave the U.S. financial system more vulnerable, not less.
Moreover, contrary to the claims of those supporting reinstatement of Glass-Steagall, GLBA does not permit the mixing of insured deposits and "risky trading" in the securities subsidiary of an FHC. GLBA specifically mandates that the banking and non-banking activities of FHCs must be conducted in separate subsidiaries, and imposes significant restrictions on inter-affiliate transactions.
GLBA also did not spawn the era of "mega banks." Very large banks existed before GLBA – they were just less diversified and, therefore, more risky. By permitting the diversification of the activities and revenue streams of financial conglomerates, GLBA helps such entities become less risky and more stable.
Finally, repealing GLBA would severely undermine the competitiveness of internationally active U.S. institutions. Large corporate clients who depend on U.S. banks for the full range of financial products and services – loans, underwriting, trading, hedging of financial risks, private equity, and asset management – would likely turn to non-U.S. institutions if Congress bans banking companies from providing non-bank financial services.
The goal of financial reform should be to correct the deficiencies in the nation's framework of supervision that left our financial system so vulnerable to crisis and the financial authorities ill-equipped to combat the crisis. Repealing GLBA would target something that had nothing to do with creating the crisis, would undermine financial stability by restricting institutional diversification, and would remove an important weapon – the ability to merge troubled financial institutions – from the arsenal of financial authorities.
Simply stated, not very smart.


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This thing looks even cooler in person. I will definitely be picking this up even though it's really not worth the price tag. I just think it's a cool nostalgia gift set. For the old Joe fans and the new ones. I wonder what kids of today would think about this set?
Thankfully I haven't picked up the new SnowJob yet. Of course he's just a repaint of the 25th version and I have dozens of them, but whatever.
I also noticed some cool Star Wars exclusives. As well they've redone the Star Wars comic packs. They look cooler now. Of course I didn't take any pictures of that stuff.
Don't forget that JLU 3 packs are on sale too. Naturally this is after I paid $15.99 for the new JLU sets. Anyway, plenty of stuff to add to your holiday wish lists and just in time. Check back in later I have a virtual TON of Japanese Monster Week stuff coming today and tomorrow. It may roll over into Sunday some as well. Such is life when you're facing down 500 ft tall creatures of mass destruction.
3 Responses to Tales from the Toy Aisle, GI JOE
I'm not sure about this one. I don't really like Snow Job. Then again, I'm only a casual fan of G.I. Joe, so I don't really know him. Still, somebody who likes Snow Job will probably be happy.
I'm actually more interested in the Burning The Fallen under Snow Job. He looks really cool, better that the normal release in my opinion.
Haha, yeah I don't follow Transformers but they did look pretty cool. This Target had all kinds of new Holiday stuff there.
I'm done with GI Joe, but the new Zartan looks pretty darn cool!


text:
Akali Build Guide by Nirelz
Not Updated For Current Season
This guide has not yet been updated for the current season. Please keep this in mind while reading. You can see the most recently updated guides on the browse guides page.
Thank You!
Your votes and comments encourage our guide authors to continue
creating helpful guides for the League of Legends community.
Akali Build
Ability Sequence
Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Akali is a very strong jungler.
This build i use when going jungle. I clean the entire jungle within 4 minutes. and reaches lvl 4 then recalling to buy before i go on a ganking spree. I keep ganking until my buffs goes off then i go take the "Easy" camp spawns before the buffs spawns again. Then i recall before taking them to buy some more + pots if i lose hp when taking buffs again. Then go out on another ganking spree.
For runes. i take enough AD runes to activate the passive. which is 6.5+ as i get 3 from masteries and 9.5 rounds up to 10 so the passive activates anyway.
The rest i go for ap to maximize the ability power early which allows me to kill golems fast enough to be able to finish jungle rotation before 4 minutes.
In the masteries i take 21/9/0 because i see it more important to have defensive than utility as i take less dmg from the mosters in the jungle allows me to take all the mosters including the buff giving mosters without recalling to buy more than 1 pot.


text: I was really hoping today that Apple today would announce something for Verizon, but it was wishful thinking. I use a Macbook which I love - but I'd love a new cell phone that would be able to sync with my macbook, most importantly with my calendar, does anyone have any suggestions. Thanks


text:
Rockford Public Schools announce campaign to abolish truancy
The City of Rockford and the Rockford Public Schools recently announced a public campaign to Abolish Chronic Truancy now.
Public Service Announcements have begun airing that call for action and community involvement. Rockford Public Schools is operating a Truancy Hotline at 966-5252.
Citizens are urged to call the hotline if they see students not in school during regular school hours. The announcement follows the Aug. 15 City Council approval of the new Rockford Daytime Truancy ordinance. The purpose of the hotline is to collect information such as where children who are skipping school are gathering.
Parents are urged to let their children know the City of Rockford will be enforcing its new daytime curfew. Teachers and District 205 employees will also be informing students of the new daytime curfew law.
Rockford has the second-highest truancy rate in the state. Students who skip school are four times more likely to turn to a life of crime. In the coming days, there will be more announcements as the Abolish Chronic Truancy campaign continues, including efforts from the business community to raise awareness and dollars.
From the Aug. 31-Sept. 6, 2005, issue


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Valdez elated as Lady Eagles triumph in her first Ateneo-La Salle clash as alumna
Because of a frantic schedule that saw her playing in Thailand for 3BB Nakornonnt, Alyssa Valdez watched her first Ateneo-La Salle match only today.
The three-time UAAP Most Valuable Player witnessed a short-handed Ateneo de Manila University Lady Eagles squad upset a hungry De La Salle University-side, much like she had done during her five-year career with the Loyola-based program.
"Everyone played today and contributed to the win.
"But La Salle will always be there, di sila bumibigay until the very end of the match and, ayun lang, very kahit less points ateneo, na minimize nila errors nila and na convert nila and naka-counter sila and nakakadepensa sila," analyzed the two-time UAAP champion.
The Phenom conceded that she really would have rather played in the match than simply watched, as alumni like her have said before.
"Excited and proud of the girls. I didn't really look sa game kasi iba 'pag nasa labas ka, you'd rather really play, 'di talaga ako tumitingin sa court, nanlalamig ako," the 23-year-old National Team pool member admitted.
"Mas kinakabahan ako sa labas. Nakita ko na 'yung sinasabi nang ibang alumni na how they feel when they watch. It's still fun pero nakakakaba talaga masyado."
The Lady Eagles have quickly established themselves as title favorites post-Valdez.
Although she dearly misses playing for the blue and white, Valdez believes this batch of Lady Eagles can win the school's third title.
"It's really a credit to coach Tai [Bundit's] system. When everyone buys into it, talagang everyone improves," said the Creamline Coolbusters skipper.
"Definitely, the girls are working hard and I know they're doing their best to get the championship."


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text: Apple Knew of iPhone Antenna Risks - WSJ.com "Engineers Aware of Antenna Risks Before Release, but CEO Jobs Liked Design Apple Inc. released its newest iPhone despite internal concerns about its antenna reception, and gave wireless carriers far less time to test the phone than is typical, according to people familiar with the matter. Since its release June 24, Apple's iPhone 4 has been dogged by reports of reception problems, yet demand for the smartphone has outstripped Apple's ability to keep it in stores. The Cupertino, Calif., company has called a news conference at its headquarters to discuss the issue Friday. Apple doesn't plan to recall the phone, a person familiar with the matter said. Apple engineers were aware of the risks associated with the new antenna design as early as a year ago, but Chief Executive Steve Jobs liked the design so much that Apple went ahead with its development, said another person familiar with the matter. The electronics giant kept such a shroud of secrecy over the iPhone 4's development that the device didn't get the kind of real-world testing that would have exposed such problems in phones by other manufacturers, said people familiar with the matter. The iPhones Apple sends to its carrier partners for testing are "stealth" phones that disguise a new device's shape and some of its functions, people familiar with the matter said. Those test phones are specifically designed so the phone can't be touched, which made it hard to catch the iPhone 4's antenna problem...." More at link above. It's one thing to make a mistake but it intolerable to come up with a flawed design on purpose just because it looks shiny.


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PRE-ORDER takes 2 weeks to delivery
View size chart


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The long term goal of this research is to determine the mechanism and effect of dopamine signaling on hormone secretion from the islet of Langerhans. Blood glucose homeostasis depends on glucose-stimulated insulin secretion (GSIS) from islet 2 cells, but we also know that non-glucose signals are important for modulating insulin secretion, and many of these signals are known to communicate through G-protein coupled receptors. Dopamine acts through a number of G-protein coupled receptors, but its signaling in the 2-cell has not been well-characterized. All current antipsychotic drugs block D2 dopamine receptors as well as other targets, and the most effective second generation antipsychotics cause significant metabolic side-effects leading to increased risks of obesity and diabetes. Unfortunately, there is no consensus about the molecular mechanisms underlying the side-effects. Since all of these anti-psychotics block D2 receptors, but not all have notable metabolic side-effects, it has been assumed that the side-effects are mediated by interactions with molecules other than D2 receptors. The 2-cell has drawn little attention as a potential target of these drugs, presumably because there are no known dopaminergic neurons terminating in the islets, nor do sufficient levels of dopamine circulate through the blood stream. However, L-DOPA does circulate in the blood stream at appropriate levels, and 2-cells contain the molecular machinery needed to convert L-DOPA to dopamine. 2- cells also express the D2 receptor and VMAT-2, which loads dopamine into secretory granules. Thus, a link may exist between D2 receptor inhibition and 2-cell dysfunction, but investigations of this link will depend on a more complete understanding of dopamine action in the 2-cell. Towards this understanding, we hypothesize that 2-cells take up L-DOPA, synthesize dopamine and package it in the insulin secretory granules, and that stimulated secretion of dopamine acts through an autocrine loop to down-regulate subsequent insulin secretion. To test this hypothesis, we will utilize state-of-the-art live cell imaging methods, many of which have been pioneered by our laboratory. These novel techniques allow us to examine intracellular and multicellular events with unprecedented specificity and resolution. We have also developed several novel microfluidic devices for the study of pancreatic islets and their secreted products, and these can all be coupled with our unique quantitative imaging approaches to provide an ideal platform for many of the proposed experiments. In this proposal, we will refine and extend our established live cell imaging approaches to address the following four specific aims: 1) to determine the effects of L-DOPA on 2-cells in terms of the generation of dopamine and resulting modulation of the intracellular signaling pathways involved in GSIS;2) to determine the intracellular signaling pathways and functional targets of dopamine receptor activation in the 2-cell;3) to determine the role of expression and trafficking of the D2 receptor and the dopamine transporter in these signaling pathways;4) to determine the effects of various second generation antipsychotic drugs on these pathways.
Narrative Dopamine is known to affect brain function and is a target for antipsychotic drugs, but it can also cause changes throughout the body. We are studying the relationship between dopamine and insulin. The knowledge gained from our work about how dopamine affects insulin production in the pancreas will be important for designing new diabetes treatments and for understanding the observed links between many antipsychotic drugs, weight gain, and an increased risk of diabetes.
|Lavagnino, Zeno; Dwight, Jason; Ustione, Alessandro et al. (2016) Snapshot Hyperspectral Light-Sheet Imaging of Signal Transduction in Live Pancreatic Islets. Biophys J 111:409-17
|Cranfill, Paula J; Sell, Brittney R; Baird, Michelle A et al. (2016) Quantitative assessment of fluorescent proteins. Nat Methods 13:557-62
|Syring, Kristen E; Boortz, Kayla A; Oeser, James K et al. (2016) Combined Deletion of Slc30a7 and Slc30a8 Unmasks a Critical Role for ZnT8 in Glucose-Stimulated Insulin Secretion. Endocrinology 157:4534-4541
|Caldwell, Brittany; Ustione, Alessandro; Piston, David W (2016) Dopamine Receptor Signaling in MIN6 β-Cells Revealed by Fluorescence Fluctuation Spectroscopy. Biophys J 111:609-18
|Benninger, Richard K P; Piston, David W (2014) Cellular communication and heterogeneity in pancreatic islet insulin secretion dynamics. Trends Endocrinol Metab 25:399-406
|Schwetz, Tara A; Reissaus, Christopher A; Piston, David W (2014) Differential stimulation of insulin secretion by GLP-1 and Kisspeptin-10. PLoS One 9:e113020
|Ustione, Alessandro; Piston, David W; Harris, Paul E (2013) Minireview: Dopaminergic regulation of insulin secretion from the pancreatic islet. Mol Endocrinol 27:1198-207
|Kumar, Ankur N; Short, Kurt W; Piston, David W (2013) A motion correction framework for time series sequences in microscopy images. Microsc Microanal 19:433-50
|Schwetz, Tara A; Ustione, Alessandro; Piston, David W (2013) Neuropeptide Y and somatostatin inhibit insulin secretion through different mechanisms. Am J Physiol Endocrinol Metab 304:E211-21
|Ustione, Alessandro; Piston, David W (2012) Dopamine synthesis and D3 receptor activation in pancreatic β-cells regulates insulin secretion and intracellular [Ca(2+)] oscillations. Mol Endocrinol 26:1928-40
Showing the most recent 10 out of 16 publications


text: 'Love of beauty is Taste. The creation of beauty is Art.' By Antranik Leave a Comment Quote by Ralph Waldo Emerson. Other posts you may enjoy: World's most powerful laser art setup to date: Global Rainbow Project 35 of The Best Photoshopped Pepper Spray Cop Meme Pics Cinemagraphs: The Four Seasons Drakensberg Mountains, Southern Africa [1300×829] Fractal Cats


text:
Skip to comments.Will Obama abandon Israel?
Posted on 04/25/2009 9:15:00 AM PDT by SonOfDarkSkies
Barack Obama's obvious comfort level with leaders of unfree countries shouldn't surprise anyone. He is not only our first black president. He is also our first president who doesn't like the free country he was elected to lead and feels his job is to change it.
Obama's cordial encounter with Venezuelan thug Hugo Chavez and his bow of deference in London to the Saudi Arabian king are extensions of behavior we have always seen on the black left. Jesse Jackson openly embraced Chavez, as well as having maintained relations with the likes of Libyan dictator Moammar Gadhafi and Yasser Arafat.
This should be kept in mind as our president now makes his own effort to bring peace to the Middle East.
It should be clear to anyone conscious and watching that central to Obama's Middle East strategy is to disabuse the long-held notion that there exists a "special relationship" between the United States and Israel. The sense of unique kinship between our country and the Jewish state has existed since Israel's founding just 60 years ago.
(Excerpt) Read more at wnd.com ...
I think Palin was a major factor. Before the VP announcement Obama was polling very badly among Jews (for a RAT). Polls were showing him around 55-60% instead of the usual 75-80%.
That shifted dramatically after he chose Palin and the MSM unleashed its lying dogs.
I can't believe that any Jew who was going to vote for McCain would switch to the Messiah simply because Palin was the VP nominee. As I said, absolutely no evidence of Palin being anything but pro-Israel and friendly to Jews in Alaska. Could you imagine that the 'Rat congresscritter (and impeached former federal judge) Alcee Hastings, addressing the Jewish 'Rat group, attacked Palin as being antisemitic (and racist) because she hunts moose?! If that's the "best" argument they can come up with, both he any Jews who would give credence to such illogic are total nitwits.
Most simply put, it's an ignorance of American history, tradition, values, and law. An ignorant people cannot remain a free people; statism thrives in a culture of idiocy.
You'd be justified in saying a lot of things about Soros, but being a Nazi isn't one of them. What he may have done is collaborate with them or bribe them to save his life, but he could never have become one of them because they would never have him for the obvious reason.
He already has. Netyanyahoo (sp) got elected because of obambi.
Thank you for reminding me of the reality of Soros' inability to join the Nazi party.
He did ascribe to their beliefs however - I was mistaken in the way I worded my rant.
Anger makes me less careful - with Soros - I would describe him as the devil if necessary for what he is doing to our nation.
I believe so.
I don't either. A far bigger issue was the neutralization of his associations, both by a media unwilling to report on them and a Republican candidate who clearly stated there was nothing to be concerned about there, that he'd be a fine President.
Samantha Power, though she only advocated US troops occupying the West Bank and Gaza, and now says she really didn't mean it.
You're right about McCain not getting into the issue of O's associations until very late, when he brought up William Ayers during the last debate. IIRC, Palin was a lot more aggressive about it than McCain was.
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text:
Though the 2010 midterm elections are barely in the rearview mirror, the campaign to win the Republican presidential nomination in 2012 has already begun. Newt Gingrich became the first potential candidate to stop in Iowa since Election Day when he made several appearances in the state as a part of a book singing tour. Sarah Palin will also be making two book signing appearances in Iowa this month, and Mike Huckabee will headline a fundraiser Sunday for the Iowa Family Policy Center.
In the aftermath of the Iowa Supreme Court's decision last year legalizing same-sex marriage and the subsequent removal of three of its justices by Iowa voters on Nov. 2nd, 2012 presidential hopefuls are learning fast that they had better come prepared to explain to Iowans their view of the proper role of judges.
For instance, Newt recently urged the four remaining justices to step down and advised the judicial nominating commission to refrain from picking radical judges. Mike Huckabee, in a telephone interview with WHO Radio's Steve Deace on Tuesday night, argued that courts may not have the last word if the other two branches of government disagreed. Former Pennsylvania Senator Rick Santorum made stops with the Anti-Retention Judge Bus the week before Election Day, and Minnesota Governor Tim Pawlenty also urged Iowans to vote against retaining the justices.
Two potential 2012 hopefuls have not yet made any public statements on Iowa's ongoing struggle with its activist Supreme Court—New Jersey Governor Chris Christie and Indiana Governor Mitch Daniels. Christie, who appeared at a fundraiser for Terry Branstad in October, made judicial issues part of his gubernatorial campaign in 2009.
Despite intense pressure to reappoint a judicial activist to the New Jersey Supreme Court, Christie stood his ground and instead nominated an originalist to the high court. New Jersey and Maine are the only two states with a judicial selection process that mirrors the federal model of executive appointment subject to senate approval.
Mitch Daniels, who recently called for a truce on social issues and didn't bat an eye at the reach of the federal stimulus plan, has shown little regard for judicial reform or originalist judges. Large majorities of the Indiana General Assembly passed legislation in 2009 that would have replaced the "merit based" judicial selection system in place in St. Joseph County. Governor Daniels vetoed the legislation with the following statement:
The current method of selecting judges for the St. Joseph Superior Court has prevailed successfully for 35 years. It is a model to be emulated, not discarded. It is not broken; it requires no repair. It has produced outstanding jurists and contains sufficient measures of public accountability. I believe it is neither necessary nor wise to re-politicize the courts of St. Joseph County.
Recently, Indiana's judicial nominating commission sent Daniels three names to fill a vacancy on the state's Supreme Court. One of the three names was Judge Robyn Moberly, who sounded very much like President Obama when she argued for judicially imposed "compassionate justice." She stated that she would make a good judge because "I bring a whole different set of life experiences to the court…I think that's what makes really great decisions. Through collaboration, discussion and debate, different life experiences come together and inform us all on what the best decision is."
Governor Daniels passed over Moberly to pick Judge Steven David, who served a chief defense counsel for terrorist detainees being held at Guantanamo Bay prison. While on the bench, David ruled that a defendant who had been convicted and twice sentenced to death for killing a police officer could not be executed due to long delays in his case.
David is also a member of the American Judicature Society, an Iowa-based organization that supports commission-based judicial selection. Since 2000, the AJS has received more than $1 million dollars from George Soro's Open Society Institute to fund its efforts which, recently, included defending Iowa's Supreme Court justices.
If Mitch Daniels wants to be president, he will have his hands full trying to explain to Iowa voters in the months ahead why he not only praised the Missouri Plan, but appointed an activist judge like David to his state's highest court.
But even if Daniels had worked to replace the Missouri Plan and pledged to appoint originalists to the bench, the names forwarded to him by the commission amply illustrate the flaws in the commission system. An unelected, unaccountable commission can decide to forward only activist applicants to the governor, forcing him to attempt to pick the lesser of two (or three) evils.
No amount of tinkering with the system or changing the makeup of the commissions can solve the greatest discrepancy in the Missouri Plan—the gatekeeper role of a handful of commissioners who are responsible to no one for their decisions. Unlike the federal model, the buck can never stop with a governor who will always be able to blame the commission for a list of applicants he must choose from.
The only solution is a state constitutional amendment that, by scrapping the entire Missouri Plan and replacing it with the federal system, would place the process in the hands of those directly accountable to the people. Anything less is window-dressing.
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text: There is nothing wrong with it. Check the oil, and if it's fine unplug the oil sensor. Start the machine, leave the choke at 1/2 choke. I don't know what you are doing but the machine runs fine. Start cutting you're grass on the highest setting and go down from there.


text:
Stocks fell hard for a second day yesterday, with the Dow Jones industrial average losing more than 120 points after a surprisingly weak...
NEW YORK — Stocks fell hard for a second day yesterday, with the Dow Jones industrial average losing more than 120 points after a surprisingly weak reading on the service sector of the economy raised concerns about the continuing impact of higher energy prices.
The Dow fell 123.75 to 10,317.36. The decline followed a drop of 94.37 on Tuesday.
Microsoft, one of the 30 Dow stocks, sank 31 cents to close at $24.67 a share. Boeing, also a Dow stock, fell 90 cents to $67.05.
Broader stock indicators were lower. The Standard & Poor's 500 index fell 18.08 to 1,196.39, and the Nasdaq composite index fell 36.34 to 2,103.02.
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Equities opened lower after Tuesday's sell-off, then fell further when the Institute for Supply Management reported that its nonmanufacturing business index, which measures the service sector, dropped to 53.3 in September from 65.0 in August.
While any reading above 50 indicates the economy is expanding, the sharp drop in the index was unexpected, following a strong report in manufacturing earlier this month. The service sector includes business activity in banking, retail, insurance, tourism and education.
Yesterday's reading, which indicated supply managers were worried about energy costs, spooked investors already nervous about the effects that rising oil and gas prices will have going forward.
But yesterday, a barrel of light crude oil settled at $62.79, down $1.11, on the New York Mercantile Exchange.
The market was still mulling Tuesday's comments from Dallas Federal Reserve Bank President Robert Fisher, who said inflation was nearing the high end of the Fed's comfort zone — a clear signal that the Fed's short-term interest rate increases would continue. The higher prices for energy have been filtering into the rest of the economy.
Investors are also jittery about earnings season, which officially starts Monday. Some companies such as Clorox have already begun to warn their earnings will not meet expectations.
"We need to get [earnings season] out of the way and see how companies are doing," said Barry Berman, head trader for Robert W. Baird & Co. in Milwaukee.
Investors are facing a Wall Street nightmare: a slower economy and higher interest rates.
Those looking for signs of a slowdown are finding them. For instance, home-equity lending at banks has slowed from a peak rate of $2 billion to $3 billion a week to "a trickle" of $100 million in the past several weeks, according to a Citigroup report.
"There's just a lot of nervousness and crosscurrents," Berman said.
One example: Homebuilder Hovnanian Enterprises fell $1.05 to $48.23 despite its report that new contracts rose 61.5 percent in September.


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text: What do we know about them? They just got rocked by UNI, though I will admit that the Refs probably played into that a little bit. They aren't a very good team, but we aren't a really good "team" either. Though I think we have seen flashes of our team recently. What do you guys think? Should be a fun game.


text:
Almost every American lives their life as a Conservative. If more people were informed, then more Conservatives would be voted into office. I approach each day with a smile because I know that the only difference between a happy person and an angry person is that the angry person is angry. Everybody has problems. Its how we deal with those problems that shapes our life.
Just damn.
If you want on the new list, FReepmail me. This IS a high-volume PING list...
The most evil agency on earth is right here in the good ole U.S.A. They have no rules, they have no one to oversee them, they are not bound by the same laws as we are, they run roughshod over those that they know have no defense. I could go on and on about this no good sorry sack of dog shit agency but I think you get my drift.
Once we confont THAT evil we will have taken our country back. Until then we are sheeple being lead to slaughter.
that bears repeating and publicising. It has a democrat party tradition to take money for the foreign enemies of the USA.
I would argue that elections alone will not solve the problem. I remember the real McGovern. I remember that Nixon won in 1972 with just over 60 percent of the popular vote and won the electoral vote 520 to 17. Yet, within two years the left drove him from office. Do not believe that Nixon brought it all on himself. Yes, covering up to protect his people was a mistake, but it was SOP for politicians. Both parties bugged each other, both parties did dirty tricks (Dick Tuck was the Dems' master and the media loved him), and both parties covered up.
Nixon was hated by the left beginning from the time he was an anti-Communist congressman in the late 1940s. It appears to me that President Bush is hated at least as much. Once "Watergate" got started there was little else the media talked about. There was some honest reporting even without talk radio and the Internet but you had to look for it. Most people watched TV network "news." I remember asking my younger co-workers what did Nixon do? None could really answer beyond, he lied.
There may not be a "Watergate" today but today's news contains a story about just who, by name, was responsible for "letting" 9/11 happen -- you know what all the forces of the left will do with that story in an election year. Next year may be when we learn just what it takes to stop the left from motivating our enemies by destroying ANOTHER wartime administration. Never again!
I don't agree with certain aspects of CFR as passed, but the way it was previously, they had already told us to shut up.....unless you're ready to open your checkbook. Access to my elected representatives should not be limited to my ability to write a check. Those SOB's better be ready to listen to me when I have a concern, money in hand or not.


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text:
RE: Helmut Zander - The Biography
Expand Messages
- To all:
I just gathered and read Jean-Marc's excerpts
and comments on Zander's biography of RS.
(These were on "Anthroposophy Tomorrow"; I
missed most of them the first time. The thread
starts here:
This, of course, is Zander's more recent book;
the big one previous was his massive "history"
of Anthroposophy in Germany.
My overall impression? -- It's in the same vein
as J-M's comment:
>>Why do radiant white doves of the Church,turn into rattlesnakes and scorpions - when they
are confronted with the true Michaelic emissary
of the Solar God - and his monumental
Yes, "rattlesnakes and scorpions" is an apt
picture. The main thing that this series of
posts brought home to me is: *hatred*.
Anthroposophy is *hated* -- not just opposed but
hated. Zander and Staudenmaier are just
examples of the form that this hatred can take
in academia, and the WC and suchlike are
examples of the form that it can take on the
Internet . . . but what we're looking at here is
something much bigger and more elemental.
The devils of Hell have always hated Christ;
that's how it appears to me. But it's a lot
harder to *understand*; this is not only
"opposition"; it is *hatred*. Steiner was the
foremost public representative of Christ in our
times, and the Anthroposophy that he gave is the
foremost, most effective expression of Christ in
our times -- so it is only natural that the
devils of Hell hate Steiner and Anthroposophy.
But how do these devils find human beings (so
many, it seems) to carry out this hatred? To
me, such viciousness doesn't seem human. I can
understand in human terms how someone could hate
someone else who had "done something" to one. I
can even understand in Reichian terms how
someone could panic and flee from whatever
causes "life energy" to flow and thus to release
stored "pain" (of all kinds) from "armor". That
is, I can understand human fear of "life energy"
(or the "Christ impulse"), but actual *hatred*?
. . . I can't quite grasp it.
But we Anthros had better find a way to wrap our
minds around it: it's here, and it's not going
away easily. We are not facing mere
"opposition"; we are facing real hatred, real
malice and malevolence. The kind that we see in
Zander's work and on the Internet manifests
mostly as the "astral murder" of slander and
distortion. But this verbal murder could become
physically murderous, as it did in Steiner's
I can observe such hatred and see how it works
-- see, that is, from the outside, but
understanding it from the inside is something
else. I'm baffled. It's easy enough to
understand hatred of someone who has inflicted
some kind of pain on a victim, but how does one
understand hatred of someone who has only freely
given Truth and Healing? Fear might be somewhat
understandable, but hatred is not, especially
not when the hatred turns into untruthful
maliciousness. Not understandable for me
anyway; I can see it, but I can't quite get
inside it.
I'm just putting this out here for
contemplation. "We" had better come to terms
with it, somehow. Impossible as it seems, it's
a reality. It's here, and it could get worse.
Think about it,
Robert Mason
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