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Conceived and designed the experiments: JW QF. Performed the experiments: JW TY. Analyzed the data: JW L. Yu YY. Contributed reagents/materials/analysis tools: JW L. Yu YY. Wrote the paper: JW QF. Clinical diagnostic and therapy: L. Yin JL Ye Shen Yongnian Shen.
Pseudohypoaldosteronism type 1 (PHA1) is a rare inherited disease characterized by resistance to the actions of aldosterone. Mutations in the subunit genes (SCNN1A, SCNN1B, SCNN1G) of the epithelial sodium channel (ENaC) and the NR3C2 gene encoding the mineralocorticoid receptor, result in systemic PHA1 and renal PHA1 respectively. Common clinical manifestations of PHA1 include salt wasting, hyperkalaemia, metabolic acidosis and elevated plasma aldosterone levels in the neonatal period. In this study, we describe the clinical and biochemical manifestations in two Chinese patients with systemic PHA1. Sequence analysis of the SCNN1A gene revealed a compound heterozygous mutation (c.1311delG and c.1439+1G>C) in one patient and a homozygous mutation (c.814_815insG) in another patient, all three variants are novel. Further analysis of the splicing pattern in a minigene construct showed that the c.1439+1G>C mutation can lead to the retainment of intron 9 as the 5′-donor splice site disappears during post-transcriptional processing of mRNA. In conclusion, our study identified three novel SCNN1A gene mutations in two Chinese patients with systemic PHA1.
Pseudohypoaldosteronism type 1 (PHA1) is a rare inherited disease characterized by resistance to the actions of aldosterone. It was first described in 1958 by Cheek and Perry [1], and common clinical manifestations include salt wasting, hyperkalaemia, metabolic acidosis and elevated plasma aldosterone levels in the neonatal period [2]. According to the clinical manifestations and Mendelian inheritance patterns, PHA1 can be classified as either Renal PHA1 (autosomal dominant, OMIM177735) or the more severe systemic PHA1 (autosomal recessive, OMIM264350) [2]. Renal PHA1 results from a defect in the tubular response to aldosterone caused by inactivating mutations in the NR3C2 gene (4q31) encoding the mineralocorticoid receptor [3]. Systemic PHA1 is caused by mutations in the genes encoding the subunits of the epithelial sodium channel (ENaC): alpha subunit (SCNN1A; 12p13), beta subunit (SCNN1B; 16p12.2-p12.1), or gamma subunit (SCNN1G; 16p12) [3]. However, some special cases of PHA1 have been reported. Hubert et al. [4] described a newborn with severe recessive PHA1 caused by two heterozygous mutations in NR3C2. Dirlewanger et al. [5] also reported that a homozygous missense mutation in SCNN1A is responsible for a transient neonatal form of PHA1.
In the 55 years since PHA was first known in the 1950s, sufficient clinical descriptions have accumulated in the literatures. Still, the symptoms of PHA1 are easily confused with that of other endocrine disorders, especially if the pediatrician cannot get specific biochemical findings [6]. The symptoms of PHA1 are easily confused with the symptoms of congenital adrenal hyperplasia (CAH) associated with 21-hydroxylase deficiency or 3-beta-hydroxysteroid dehydrogenase deficiency; and the symptoms of hypoaldosteronism (HA) due to aldosterone deficiency, antenatal or infantile Bartter syndrome. In addition, respiratory tract infections associated with PHA1 may be mistaken for symptoms of cystic fibrosis [7]. Such confusion delays diagnosis when prompt treatment of PHA1 is essential, as death may occur as a result of salt depletion and high blood potassium level [8].
In this study, two pediatric patients who suffer from PHA1 were promptly diagnosed with molecular genetic tests and treated. Using molecular genetic tests, we identified three novel mutations in the SCNN1A gene. We further confirmed the pathogenicity of the c.1439+1G>C mutation by analyzing its effect on splicing in a minigene construct.
A 5-day-old female infant was admitted to the neonatal intensive care unit as a result of her refusal to be breastfeed, poor response, weak cries and cold extremities. Physical examination: Weight 3100 g (SDS=−0.56), Height 49.5 cm (SDS=−0.37), Heart rate 125/min, Respiratory rate 36/min, Blood pressure 71/32 mmHg, Rectal temperature (37°C), SpO2 99%. Auscultation: no lung crackles and heart murmur. Palpation: the liver edge about 2.5 cm below the costal margin, spleen is not palpable. Skin color: mild jaundice. Genital examination: female characteristics. Two days later, symptoms of severe dehydration and vomiting appeared. Biochemical laboratory tests showed that she had severe hyperkalemia with K+10.1 mmol/L, Na+105 mmol/L, Cl+83 mmol/L, PH 7.31, BE(B) −10.8 mmol/L and the trans-tubular potassium gradient (TTKG) is 4. Hormone indicator is as follows: aldosterone 1.08 nmol/L (range 0.17–0.47), plasma renin activity 14.0 ug/L/h (range 0–15), ACTH 20.4 pmol/L, cortisol 687.2 nmol/L, testosterone 0.94 nmol/L, and 17-OHP 25 nmol/L.
PHA1 was initially suspected on the basis of her clinical features, and the infant was immediately given a supplement of 10%NaCl. The results of hormone levels and TTKG value tests provided further evidence of PHA1 and the clinical diagnosis was confirmed by molecular genetic testing. After increasing doses of oral 10%NaCl to 30 mEq/kg/d and doses of ion-exchange resins to 1g/kg/d, the serum potassium level was controlled at 4.5 to 5.5 mmol/L. Her development seemed normal at the last follow-up visit (26 months). At that time, her plasma concentration of aldosterone is 1.25 nmol/L and plasma renin activity is 1.67 ug/L/h. Weight is 12.3 kg (SDS=0.11), Height is 85 cm (SDS=−0.02).
A 2-months old female infant was referred to our hospital with main complaint of electrolyte imbalance since she was born. Physical examination: Weight 4750 g (SDS=−4.13), Height 51.1 cm (SDS=−3.17), Heart rate 117/min, Respiratory rate 33/min, Blood pressure 80/35 mmHg. Genital examination: female characteristics. Other examination results showed that she is without lung crackles or heart murmur, and has normal liver and spleen size. This patient was born after 38 weeks of pregnancy. She weighed 2900 g (SDS=−0.65) at birth. At seven days of age, She developed signs of hyponatremia, hyperkalaemia and metabolic acidosis. She had initially been diagnosed with CAH in another hospital on account of her clinical presentation. However, 9α-fluorohydrocortisone (9α-FHC) supplement therapy was ineffective. There was no history of parental consanguinity. Laboratory test results are as follows: K+6.1 mmol/L, Na+125 mmol/L, Cl+92 mmol/L, PH 7.34, BE(B) −6.8 mmol/L and the TTKG is 7. Hormone indicator is as follows: aldosterone 0.58 nmol/L (range 0.17–0.47), plasma renin activity 10.1 ug/L/h (range 0–15), ACTH 4.5 pmol/L, cortisol 460.9 nmol/L, testosterone 0.42 nmol/L, and 17-OHP 13 nmol/L.
After obtaining the molecular diagnostic result, the baby was definitively diagnosed with PHA1. The serum potassium level was controlled with an intake of 10%NaCl at 10 mEq/kg/d and ion-exchange resins at 0.6 g/kg/d. At her last follow up at 12 months, physical examination showed normal results and her serum electrolytes are stable. Her weight was 9.5 kg (SDS=−0.09), and her height was 73 cm (SDS=−0.21).
The study protocol was approved by the ethics committee of the SCMC, and informed consent was obtained from the family members and normal subjects.
The genomic DNA of the patients and their parents was isolated from whole blood samples by proteinase K digestion and phenol/chloroform extraction. An additional group of 105 Chinese subjects with no history of PHA1 were recruited as controls to test whether the mutations found are common polymorphisms. The study protocol was approved by the ethics committee of the hospital, and informed consent was obtained from family members and normal subjects.
All of the exons and exon-intron boundaries of the NR3C2 (GenBank NM_000901.2), SCNN1A (GenBank NM_001038.5), SCNN1B (GenBank NM_000336.2) and SCNN1G (GenBank NM_001039.3) gene were amplified by PCR (TaKaRa, Dalian, China) using primers listed in Table 1. Primers were designed using Primer 3 software (http://frodo.wi.mit.edu/primer3/). The amplified PCR products were purified from agarose gel using QIAquick Gel Extraction Kit (Qiagen, Hilden, Germany) and sequenced via the ABI3730XL sequencer (Applied Biosystems, CA, USA).
The splice region (c.1439+1, intron 9) of SCNN1A gene was amplified with specific primer pair (5′-CCCaagcttGTAGAGAAAGCTGAGGTGCC-3′, and 3′-GACGCCGATTCAGAGAAAAAcctaggCTG-5′) using PrimeSTAR HS DNA Polymerase (TaKaRa, Dalian, China). The forward and reverse primer sequences are located in intron 8 and in 3′UTR, respectively. The length of the PCR product is 1,863 bp. The restriction enzyme sites HindIII and BamHI were inserted into the primer sequences to enable directional cloning. DNA from a normal individual was used as control. Minigene amplification products were purified, digested, and ligated into the pcDNA3.1/Myc-His B vector (Invitrogen, CA, USA) according to the protocol of the manufacturer. The constructions were used to transform E. coli DH5α competent cells, and putative recombinant colonies were selected to verify the presence of the correct mutation by sequencing recovered plasmids. The recombinant plasmids with either wild-type or mutant SCNN1A were transfected into HEK 293 cells. Blank vector was used as a control.
Thirty-six hours after transfection, total RNA from the HEK 293 cells was extracted with an RNeasy Mini Kit (Qiagen, Hilden, Germany). cDNA chains were obtained by reverse transcription (TaKaRa, Dalian, China) and target fragment was amplified with another primer pair (5′-ttgacttctcctcagaccacc-3′, and 5′-agggtgaccatcgtgacagag-3′). The forward and reverse primer sequences are located in exon 9 and at the junction between exon 10 and 11, respectively. The expected length of the PCR product is 256 bp. Then, PCR products were analyzed by running in 2% agarose gel stained with ethidium bromide and sequenced.
In case 1, the patient and her parents were genotyped by direct nucleotide sequencing. We found that the patient had compound heterozygous mutations in the SCNN1A gene. One mutation was a deletion of a single base "guanine" (c.1311delG) in exon 8, which resulted in a frameshift leading to a premature stop codon (p.Arg438GlyfsX43). The other mutation was a transversion of guanine to cytosine (c.1439+1G>C) in the first base of the 5′-donor splice site of intron 9. This mutation occurs at a highly conserved "AG-gt" sequence of the exon-intron boundary region. The predicted effect of this G>C mutation is a disruption normal splicing, possibly resulting in the retainment of intron 9 of the SCNN1A gene. No other mutations were found in the entire exons and the exon-intron boundaries of the patient's NR3C2, SCNN1B and SCNN1G gene. The patient's mother was heterozygous for the c.1311delG mutation, and her father was heterozygous for the c.1439+1G>C mutation. No such mutations were observed in the 105 unrelated healthy individuals. Consequently, it was concluded that the patient is a novel compound heterozygous individual who inherited the maternal c.1311delG mutation and the paternal c.1439+1G>C mutation (Fig. 1A).
In case 2, direct sequencing of the entire SCNN1A gene in the patient revealed a homozygous insertion of one "G" in exon 4 (c.814_815insG). This frameshift mutation results in a premature stop codon (p.Glu272GlyfsX38). The mutation was also found in heterozygous state in both of her parents. DNA samples from 105 unrelated healthy individuals were subsequently tested for this mutation, and it was not found in these individuals. Therefore, we concluded that the patient is a novel homozygous individual who inherited a copy of the c.814_815insG mutation from each of her heterozygous parents (Fig. 1B).
To assess the impact of the splice-site mutation, a minigene construct was generated and tested in transiently transfected cultured cells. HEK 293 cells were transfected with the mutant SCNN1A, wild type SCNN1A, or empty pcDNA3.1 vector (negative control). Three independent replicates were tested, and GAPDH was used as a control for RNA quality and quantity. A difference in the size of the cDNA fragment was observed between wild type and mutated SCNN1A. The wild-type SCNN1A resulted in a single band at 256 bp, whereas the mutated construct resulted in a longer band at 361 bp. Sequencing confirmed that RNA resulted from mutant SCNN1A construct contained the 105 nucleotides that constitute intron 9. The loss of the 5′-donor splice site at the exon-intron boundary resulted in the retainment of intron 9 in the RNA (Fig. 2).
Pediatricians should consider the possibility of PHA1 when encountering infants with unexplained hyponatremia, hyperkalemia and metabolic acidosis [2]. PHA1 diagnosis is based on elevated plasma aldosterone and renin levels, especially when high-dose mineralocorticoid treatment cannot remedy the imbalance of potassium and salt. Schweiger et al. [9] suggested that TTKG index may be helpful in the acute setting to determine whether mineralocorticoid deficiency or resistance is leading to hyperkalemia. A typical TTKG value in a normal person on a normal diet is 8–9 [10]. During hyperkalemia or high potassium intake, more potassium should be excreted in the urine and the TTKG should be above 10. If the TTKG is low during hyperkalemia, and this is also accompanied by hyponatremia and increased urine sodium excretion, the presence of mineralocorticoid deficiency or resistance should be considered. Belot et al. [11] reported that there are two clinical manifestations in patients with systemic PHA1, including life-threatening weight loss and early cutaneous involvement. The dermatitis may be due to high salt concentration in sweat. It is recommended for weight changes to be monitored closely, and for sweat test (which measures the concentration of chloride) to be administered for early diagnosis [11]. In addition, detailed family history is often crucial.
In our case, both patients had signs of salt loss soon after birth, including hyponatremia, hyperkalemia, and metabolic acidosis. We considered the possibility of "PHA1" in accordance with their hormone levels and TTKG results. Molecular genetic tests were performed on each patient and her family in order to confirm the clinical diagnosis. All of the exons and exon-intron boundaries of the NR3C2, SCNN1A, SCNN1B and SCNN1G genes were sequenced by Sanger method. The results showed that the two patients had novel mutations in the SCNN1A gene respectively.
Since the first identification of mutations in the Saudi and Iranian Jewish kindred of PHA1 [12], nearly 25 kinds of mutations have been identified in SCNN1A gene, including missense/nonsense mutations, splicing mutations, small insertions/deletions, and gross deletions [7], [13]–[16]. However, no mutations have been reported in the Chinese population. We have successfully identified two novel frameshift mutations (c.1311delG and c.814_815insG) and a novel splicing mutation (c.1439+1G>C) in the SCNN1A gene in two Chinese patients with systemic PHA1.
The SCNN1A gene contains 13 exons and encodes the alpha subunit of the ENaC, which is expressed in the distal nephron and regulated by aldosterone [17]. The ENaC is the rate-limiting step for sodium reabsorption in the apical membrane of epithelia [18]. It plays a major role in the Na+- and K+-ion homeostasis, and has a high affinity for the potassium-sparing diuretics amiloride and triamterene. In our study, the frameshift mutations c.1311delG and c.814_815insG induce premature termination of mRNA translation and cause loss of the C-terminal domain (extracellular, helical and cytoplasmic) of the protein. The splicing site mutation (c.1439+1G>C) can lead to the retention of intron 9 as the 5′-donor splice site disappears during post-transcriptional processing of mRNA. All of these novel mutations are thought to result in an absence of a functional αENaC subunit, and constitute the molecular basis for systemic PHA1 phenotype.
At present, the main treatment for PHA1 is the intake of high doses of sodium together with ion exchange resins and dietary manipulations to reduce potassium levels [8]. During the course of treatment, clinicians must gradually adjust the dose according to the serum electrolytes and hormone levels [10], [11]. When treatment is effective, PHA1 patients will be able to maintain the right balance of electrolytes and resume normal growth and development; their plasma concentration of aldosterone and renin activity will be reduced or return to normal [8]. In order to reach such successful treatment outcome, patients must take medicine on time, maintain the right dosage, avoid high potassium foods and closely observe signs and symptoms of PHA1 [8]. In our case, patient from case 1 was hospitalized again after four months due to hyperkalemia caused by diarrhea. Because both patients suffer from the systemic form of PHA1, both may need lifelong therapy. Because PHA1 is rare, the relationship between genotype and phenotype is not yet clear as a result of lack of sufficient cases. However, our study has brought us a step closer to understanding this relationship, and may ultimately contribute to the goal of finding a simpler and more effective treatment for these patients.
We identified three novel SCNN1A gene mutations in two Chinese patients with systemic PHA1. The c.1311delG mutation and the c.814_815insG mutation are both frameshift mutations that lead to premature stop codon. As demonstrated by the functional analysis using an in vitro minigene system, the third c.1439+1G>C mutation leads to aberrant splicing, in which intron 9 is retains as the 5′-donor splice site of intron 9 disappeared.
We thank Dr. Bai-lin Wu, Dr. Yiping Shen (Boston Children's Hospital) and Miss Sydney Song for their critical reading of the manuscript. We are deeply grateful to the patients and their families for participating in this study.
The study was supported by the National Natural Science Foundation of China (Grant No. 81201353) and Research Fund of Health Bureau of Shanghai Municipality (Grant No. 20114y072). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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GraphicRiver Valentines Day Hearts 4152903
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text: Just wanted everyone to know that I am now running a Sense enabled Froyo OS from HTC on my EVo. The download link was on Engadget but was taken down upon request by HTC. If you search hard (not really that hard), you can find a mirror to the download link. Before installing be aware that HTC DOES NOT WANT you to Install this version. They are saying its not the complete version, so install at your own risk. I installed using these precise instructions: My thoughts so far are the following: NOTE 1: IT killed my free wifi tether that was free at launch. Now its time for that extra 30 per month. I downloaded PDA NET (USB tether) and using that for now. NOTE 2: Camera works fine, no force closes, everything works. NOTE 3: Went to engadget to watch a video on my mobile browser to check out the flash. It works, but video froze halfway through. Did not try again. Note 4: Flashlight app rocks Note 5: Seems faster and more responsive. --------------------------------------------------- I downloaded and installed the update using the precise instructions below, posted by another user on Engadget: 1) DL the zip file from the article link. 2) Rename the zip file to update.zip 3) Move the update.zip file to the root folder of your SD card. If you plug your phone into a USB cable tethered to your computer, this should be the first folder (On my computer it mounted as E:\) Just drop it in there. 4) Disconnect your phone from your computer 5) Power down the phone by holding the power button and selecting Power Down. 6) After it has powered down hold the Volume Up button down (not the down button. Hold the Up button Down.) With this held down, hold down the power button. Keep them both held down until you see the white background screen with text of different colors on it. 7) Use the up and down arrow keys to navigate to Bootloader. 8) With Bootloader highlighted hit the power key (it acts as an enter key in this menu). 9) At the next menu wait a few seconds. The screen will flash across some text about trying to load something. 10) Once you can navigate again with the volume keys, go to Recovery. 11) Hit the power key when Recovery is highlighted. 12) Wait for the phone to displays a small image of a phone with a red triangle and exclamation point. 13) Hold down both the Volume Up and Power buttons AGAIN. 14) Keep them held down until you see more options come up. One of them should be "load from zip file: update.zip" something to that effect. 15) Navigate to it with the volume keys. Hit the power button to select. 16) It'll start doing it's thing and will take awhile to finish. 17) Eventually you will see more options to select and it will say it succeeded at something. 18) Select the restart option. 19) It'll take it's time doing more stuff again. 20) It will eventually reboot on it's own. 21) You will think you are all done since you will see the unlock screen. Try to unlock it, or wait a little bit, and you will see an HTC screen. 22) Click through the "Your stuff is updated" prompt (not exact text) 23) It will show a progress wheel and counting percentage. 24) Wait. 25) Go through the "tutorial" stuff. 26) Wait some more (Loading..) 27) You should be done.


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A Guide to the Business Analysis Body of Knowledge® (BABOK® Guide) Version 2.0
Order ID: IIBA-200911231134-455082
Licensed to Gustavo Simues
International Institute of Business Analysis, Toronto, Ontario, Canada. ©2005, 2006, 2008, 2009, International Institute of Business Analysis. All rights reserved. Portions of Appendix A: Glossaryare from The Software Requirements Memory Jogger, by Ellen Gottesdiener, ©2005 GOAL/QPC and are used with permission. Cover Image ©2006 iStockphoto.com/Damkier Media Group. Version 1.0 and 1.4 published 2005. Version 1.6 Draft published 2006. Version 1.6 Final published 2008. Version 2.0 published 2009. Second Printing. ISBN-13: 978-0-9811292-1-1 (print) ISBN-13: 978-0-9811292-2-8 (PDF and EBook)Permisson is granted to reproduce this document for your own personal, professional, or educational use. If you have purchased a license to use this document from IIBA®, you may transfer ownership to a third party. IIBA® Members may not transfer ownership of their complimentary copy. This document is provided to the business analysis community for educational purposes. IIBA® does not warrant that itis suitable for any other purpose and makes no expressed or implied warranty of any kind and assumes no responsibility for errors or omissions. No liability is assumed for incidental or consequential damages in connection with or arising out of the use of the information contained herein. IIBA®, the IIBA® logo, BABOK® and Business Analysis Body of Knowledge® are registered trademarks owned byInternational Institute of Business Analysis. CBAP® is a registered certification mark owned by International Institute of Business Analysis. Certified Business Analysis Professional, EEP and the EEP logo are trademarks owned by International Institute of Business Analysis. CMMI® is a registered trademark of Carnegie Mellon University. COBIT is a trademark of the Information Systems Audit and ControlAssociation and the IT Governance Institute. ITIL® is a registered trademark of the Office of Government Commerce in the United Kingdom and other countries. TOGAF is a trademark of The Open Group in the US and other countries. Zachman Framework for Enterprise Architecture is a trademark of the Zachman Institute for Framework Advancement. No challenge to the status or ownership of these or anyother trademarked terms contained herein is intended by the International Institute of Business Analysis. Any inquiries regarding this publication, requests for usage rights for the material included herein, or corrections should be sent by email to firstname.lastname@example.com.
Order ID: IIBA-200911231134-455082
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Table of Contents
Preface Chapter 1: Introduction
1.1 1.2 1.31.4 1.5 1.6 1.7 1.8 What is the Business Analysis Body of Knowledge? What is Business Analysis? Key Concepts Knowledge Areas Tasks Techniques Underlying Competencies Other Sources of Business Analysis Information
1 3
3 3 4 6 8 13 15 15
Chapter 2: Business Analysis Planning & Monitoring
2.1 2.2 2.3 2.4 2.5 2.6 Plan Business Analysis Approach Conduct Stakeholder Analysis Plan BusinessAnalysis Activities Plan Business Analysis Communication Plan Requirements Management Process Manage Business Analysis Performance
17 24 31 37 42 49
Chapter 3: Elicitation
3.1 3.2 3.3 3.4 Prepare for Elicitation Conduct Elicitation Activity Document Elicitation Results Confirm Elicitation Results
54 56 59 61
Chapter 4: Requirements Management & Communication
4.1 4.2 4.3 4.4 4.5Manage Solution Scope & Requirements Manage Requirements Traceability Maintain Requirements for Re-use Prepare Requirements Package Communicate Requirements
63 67 70 72 77
Chapter 5: Enterprise Analysis
5.1 5.2 5.3 5.4 5.5 Define Business Need Assess Capability Gaps Determine Solution Approach Define Solution Scope Define Business Case
81 85 88 91 94 iii
BABOK® Guide, Version...


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At this time (February 1st) we're waiting on the data transfer project to conclude before making the 2016 Progress Report available. The report will be submitted through the 3.1 site and the Certification Board has not yet set a due date. As soon as it is available, Austin staff will post instructions to the 3.1 landing page and cross post to Facebook.
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As long as the training covers the objectives of the SFFMA Certification Program, each of the following options credits toward certification.
On this last option, a "uniquely qualified individual" must have the approval of the department's fire chief and certification coordinator. An example would be a manufacturer representative providing vehicle familiarization training.


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Build Guide by .Evelynn.1
Not Updated For Current Season
This guide has not yet been updated for the current season. Please keep this in mind while reading. You can see the most recently updated guides on the browse guides page.
Thank You!
Your votes and comments encourage our guide authors to continue
creating helpful guides for the League of Legends community.
Twitch Build
Ability Sequence
Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
There are other good Twitch builds out there, and I'm not saying this is going to be some sort of amazing, revolutionary guide which is going to be better than all the rest. This is just the way that I play Twitch, and I find that it is pretty successful and works well for me. So without further ado, let's move on to the guide itself. For this purpose I selected
Build one
In this build I featured early game (and generally all-time) survivability, because it is when Twitch is most vulnerable. Being a squishy character, he needs all the extra survivability he can get in order to farm well to get those dps items he needs. For this purpose I put in flat health Quintessences, magic resistance per level Glyphs, mana regeneration Seals and armour penetration Marks.


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427 Tasting Notes
Backlogging, this is really good and nice when you just want a tea bag that is decaf. I taste is a medium strength peppermint with some vanilla. I added some sugar. This is pretty good and is comforting to me and nice when I am feeling lazy and wan't something quick.
Backlogging I got this awhile back in a swap from momo thank you very good. This tastes like peach with abit of orange and I can taste the green tea to,and I added some sugar. I may of over steeped because the green tea in this is a tad strong for me and will be more careful next time. This is really good the fruit with the peach and orange taste natural and strong and very good. thank you so much momo.
I have been drinking a cup of this. a really good balanced in terms of flavor tea with a medium amount of peppermint and some vanilla. I added some sugar to. I can't not have some sugar in my teas. This is a good tea.
One of these days I need to get all the teas I have added to my cupboard and drink more.
Thank you Kittenna for sending me some of this. I added some sugar. I believe I can taste the lime with some creamyness and some apple and mabe touchs of the the other ingredients and the green tea. This is pretty good. Not overly tart or anything. Thanks for letting me try this before buying a larger amount Kittenna.
I got this awhile back from TeaEqualsBliss. Thank you very much. There is good sized pieces and chunks of fruit. This smells like strawberry and green tea. Tastes like strawberry with abit of mango slight pineapple and green tea tea. I added some sugar. This is pretty good. I have only have,had one cup so far. May try iced next time.


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The United States Embassy in Mexico issued a travel warning for U.S. citizens traveling to the Mexican state of Guerrero, which includes the resort destination Acapulco, in the wake of violence and unrest following the disappearance of 43 students there.
Embassy personnel have been instructed "to defer non-essential travel to Acapulco, by air or land" and are prohibited from traveling by road in any other part of the state. The Embassy, based in Mexico City, cautions American citizens to follow the same guidelines.
Unrest in the area has grown since 43 university students went missing on Sept. 26. It is believed that corrupt local police turned the students over to drug gang members.
Demonstrators in Guerrero have blocked highways, taken control of toll booths, hijacked buses and blockaded Acapulco's airport.


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When we hold a printed piece that features white ink, we know intuitively that it's special—the colors and textures pop in a way that traditional inks just can't capture.…
If you follow one guideline when creating direct mail pieces, make it the 40/40/20 Rule.
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Do you know how to plan for a direct mail marketing campaign? Download our free


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The crew of Avargalum Ivargalum had a rattling experience during the shoot of the movie. While shooting a big wave washed the sands beneath there feet and took them deep with a lash. The victims included 4 of the crew members.
Others who witnessed the event stood gaping and ensued on a frantic search for the washed away victims. But to their relief another a "blessed wave" washed the drowned to the shore banging them to the rocks. Soon help arrived as fishermen and crew rushed to the spot as those struggling were trapped among the rocks.
The shooting for the flick was called off as the team abandoned the spot.
Recalling the incident Director Veerapandian said "There was a board warning that not to venture into the sea because it was a dangerous area. Since the sea was not rough we shot there. The fisherman folks said that it is very difficult to survive if anyone gets stuck up in these rocks because they are very deep. I am still shivering if I think of the incident."
Well that's a narrow escape and a lesson well learnt we must say.


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Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
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Last week the boyfriend and I took a trip up to Taylor's Falls. It was over 100°F in the metro area, so we looked at surrounding areas and noticed that Taylor's Fall was only 93°F. We packed a lunch, pulled on our hiking boots, and headed north. A town near Taylor's Falls boasts the Franconia Sculpture Park, so we dropped by there was well. The Park was empty on such a hot day and we were both drenched in our own sweat, so we only stopped by for a few minutes - enough to see some awesome artist-designed, playable sculptures. Northern Minnesota is one of my favourite places on Earth. There are few places that I am as comfortable as I am along the shores of Lake Superior or in the thick of the woods.
Monday, September 2, 2013
Taylor's Falls, MN + Franconia Scultpture Park
Posted by chloe at 12:40 PM
Tags: life lately, photography
2 comments:
- Milex said...
- September 2, 2013 at 2:31 PM
- Rachel Haes said...
Lovely photos! ^-^
- September 2, 2013 at 7:48 PM
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One Down, Two to Go
Gigantic class marking is finished and will be entered into the system tomorrow. The other two classes aren't quite so challenging, although it will take me all day tomorrow and part of Thursday to complete the exams and tabulate marks in the not-quite-so-giant-sized class of 80-some. Even with Excel auto-calculation, it takes a while to ensure all the input's correct and to make decisions about marks on the cusp of the pass/fail and other divides.
I did find that I can use the view student section of WebCT to push their exam and final marks to the students "My Grades" tool. Wonder how long it'll take before I get the first complaints?


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McGahern's rare oul' times in the city
John Boland on a new book that chronicles the late, great writer's time in Dublin
If James Joyce is celebrated as the great chronicler of our urban life, John McGahern is widely regarded as his polar opposite -- the quintessential countryman who was only truly at home among the fields, villages and small towns of rural Ireland.
This view of McGahern comes from the novels and stories themselves, most of which are set in the Roscommon/Leitrim hinterland that bred him and to which he later returned. Yet he spent many of his formative younger years in Dublin, where he completed his education, worked as a teacher, formed important friendships, socialised in the city's bars and dancehalls, conducted love affairs and wrote the early fiction that would change his life.
This Dublin of the 1950s and 1960s is photographically evoked in the latest edition of The John McGahern Yearbook, and it was evoked in prose by McGahern himself when, towards the end of Memoir, which was published in the months before his death in 2006, he wrote: "My life in the Dublin of the time would not have been much different to the lives of many young men. We worked.
"We went to dancehalls and cinemas and theatres; the big hurling and football matches in Croke Park, race meetings in the Phoenix Park or Baldoyle or Leopardstown; we met and talked and drank and argued in bars."
And he recalled that "the girls we picked up in dancehalls we courted in doorways and back alleys, and on dates took them to cinemas or out to places like Howth by the sea".
As for the girls themselves, they "didn't drink stout or beer; the more adventurous had wine or gins-and-tonics and even brandies; most of them didn't drink alcohol" -- although one who did was the late novelist and memoirist Nuala O'Faolain, with whom he had a liaison.
Dublin's pub life was an attraction, too, and throughout his autobiographical writings there are mentions of particular bars in the vicinity of O'Connell Street and Grafton Street, though he recoiled from the "violence and megalomania and darkness" he encountered in some of the more "bohemian bars" -- reserving a particular distaste for McDaid's of Harry Street, the haunt of Patrick Kavanagh, Anthony Cronin, John Jordan and a motley crew of lesser talents and desperate hangers-on.
This raffish milieu, memorably evoked in Anthony Cronin's 1976 memoir Dead as Doornails, received withering treatment from McGahern, who declared that "a single visit to McDaid's was enough to cure me of any desire for literary company for a month. Like all closed, self-protective societies, they believed that everything of importance took place within their circle, while all of them were constantly looking outwards without seeing in this any contradiction".
He had just as little time for the regime he underwent in St Patrick's teacher-training college in Drumcondra. "We were not trusted," he recalled in a 1997 essay. "I don't think they seriously wanted to educate us. In fact, you could get into trouble for reading books in the study hall."
As for his teaching years in Belgrove school in Clontarf, although he wrote in Memoir that he "liked the eight-year-old boys I taught" and that "I believe most of them grew to trust and like me", those callers to RTé's Liveline some months back who had less benign memories of his teaching style might prefer to agree with his admission in the 1997 essay that "I didn't enjoy teaching" and that "there is a certain discipline that is pleasurable, but I wouldn't call that enjoyable".
Archbishop John Charles McQuaid, who didn't find McGahern's banned second novel The Dark (1965) in any way enjoyable, put paid to his teaching career, though it was his (at the time recent) marriage to a divorced Finnish woman in a registry office that was seized on by the Irish Teachers' Union as a reason for not opposing his sacking.
As the union's general secretary told him: "If it was just the auld book we might have been able to do something for you, but with marrying this foreign woman you have turned yourself into a hopeless case entirely" -- adding that anyway there had been "hundreds of thousands of Irish girls with their tongues out for a husband".
McGahern, though, countered by observing that he hadn't noticed too many tongues pointing in his direction.
That anecdote is told in Memoir and the incident marked the ending of McGahern's life in Dublin, though he retained a fondness for the city, especially its less pretentious bars and restaurants -- Wynn's on Lower Abbey Street, Larry Tobin's on Duke Street and Botticelli's in Temple Bar were special favourites -- and in later years he and his wife Madeline acquired a little house in Stoneybatter.
But the Dublin that helped to shape him was largely gone, though it's preserved in some of his finest short stories. There you'll find "the lighted globes inside the Scotch House" on Burgh Quay, where the customers "waited impatiently on the slow pulling of the pints". Or St Stephen's Green in the evening, which "looked full of peace within its green railings".
Or Webb's bookshop, the floor of which had been "freshly sprinkled and swept" although it "was dark within after the river light". Or the "sense of a cool dark waiting in Mooney's, a barman arranging ashtrays on the marble where you could hear in the silence footsteps going up and down Grafton Street".
Or, indeed, on the same Grafton Street, "aimlessly strolling in one of the lazy, lovely Saturday mornings in spring" and relishing a "time that did not have to run to any conclusion". These are evocations as memorable as anything in Joyce of a capital city's haunting hold on the imagination.
The John McGahern Yearbook, Volume 4, is compiled and edited by John Kenny and published by NUI Galway at €35.
Indo Review


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- Please select a date to see the proper prices!
- Meal can be requested on the spot
Best offer
46 € / person / night, no meal
Description of the accommodation:
Rooms, services Should you be looking for a hotel in Romania, we suggest you take a look at the offers of Casa Wagner Brasov. 25 comfortably furnished rooms are offered by the hotel to guests looking for accommodation in Braşov. Car rental service and organized city tours will help you discover the most important attractions. Nearby table tennis, bike rental and billiard opportunities may provide an excellent option for those who love to spend their leisure time actively. The bar can be an ideal place for a meeting or a pleasant evening talk. In the safe you may secure your valuables. Wireless Internet connection (WiFi) is available at the hotel, enabling portable devices and smartphones to go online. The exact equipment and the exact list of available services of Casa Wagner Brasov can be read on the information sheet below.
Payment Advance payment by credit card or providing credit card guarantee may be necessary for finalizing the reservation, depending on the chosen date, room and price.
Arrival, opening hours The earliest time for arrival and check-in is 12:00, the latest time for departure and check-out is 14:00. The personnel is at your service in Romanian and English languages.
Casa Wagner Brasov rooms Rooms
- Please select a date to see the proper prices!
Accommodation services
Free WiFi in shared places
Relaxation: Table-tennis, Billiard, Bike rental at the accommodation
Organized sightseeing nearby, Car rental nearby
Bar, Safe deposit box
Hairdryer, Desk in the room, Mini-bar


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Kurt Kaletka
I have not done voice work before. As a teacher of English as a second language, I speak clearly to large classes regularly.
English (North American), French
French, German, North American, Russian, US Midwest (Chicago, Great Lakes)
Middle Aged, Senior, Teen, Young Adult
Special Skills
Audiobooks, Business, Cartoons, Documentaries, Educational, Internet, Movie Trailers, Podcasting, Radio, Telephone, Television, Videogames
—Giving lessons in high school classrooms.
—Conducting corporate training.
—I am currently developing a podcast with an associate.
—University of Massachusetts - Boston, MA (M.A., Applied Linguistics)
—Pennsylvania State University - University Park, PA (B.A. English, minors in History and French)
Payment Terms
Hire Kurt as a voice actor. Payment is made through Voices.com SurePay, an escrow service that guarantees your work is done to your satisfaction. Send payment securely by Visa, Mastercard or PayPal through Voices.com then download your files from the website.
Watch a video to see how to make a payment
Next Steps
To contact Kurt Kaletka about your project, request a quote today. We'll walk you through the process step-by-step. It's fast and easy.
This talent has not uploaded any demos yet.
Hire Kurt Kaletka as a voice actor. Working with Kurt Kaletka is fast and easy. We'll walk you through the process step-by-step.
Request a quote for your project today.


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826 Valencia's Bookmaking Seminar Approaches
That uneasiness even tech-savvy readers feel about e-books—what about the smell of binding glue? the sound of turning pages?—demonstrates how even if we accept digital readers, we still love the heft and texture of an old-fashioned paper book.
If you're interested in creating that heft and feel yourself, you'll find no better event than the Night Writer Society's seminar on bookmaking, this Friday at 7:30 in San Francisco....more


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you can discover your new favorite mini comic and get to know the artist personally.
Josh Burggraf is one of those dudes who piss me off at how amazing and fast he is.
You've seen the poster he made for PACC (just scroll down a few posts).
I've worked with him on a handful of books and he is always the first person done with the most impressive detailed insane stories. i mean even his shitty napkin scrawls are amazing!
His work ethic is that of a sweatshop employee of the month that is a anal perfectionist. His work in the 3D anthology MATH FICTION was a huge stand out (literally and figuratively). He's also graced the pages of SECRET PRISON and the louisvile based anthology CATCH-UP and watch out for him in the JOSH BAYER edited anthology SUSPECT DEVICE premiering at PACC!
Josh will have his Grawlix nominated MONGOLOIDS REVENGE on hand as well as his new book KID SPACE HEATER. I saw an advance copy of kid space heater, and i must say, not only is it the best work he's ever done but it might be the best new work ive seen ALL YEAR. like serious.
his work is an amazing mix of urban lifestyle, jack kirby sci-fi, animal people, and weirdness that makes you think if theres some sort of deeper meaning to it all, with a style that teeters on mainstream work and complete underground indy master, in short his work is genius.
Come by PACC and get Josh to sign copies of his books now before he's to fucking huge and famous to ever come back.


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GraphicRiver Chocolate Vector 8422535
Stock Vector \ Objects \ Food
Background \ Texture \ Square \ Vector \ Segments \ VectorChocolate \ Pattern
Stock Vector - Chocolate Vector 8422535 by iunewind @ GraphicRiver
Stock Vector \ Objects \ Food
Chocolate vector plate in torn cover on white background
Layered: No; Graphics Files Included: JPG Image, Vector EPS; Minimum Adobe CS Version: CS.
Zombie ; Medical Bottle; Gun Set; Spotlights; Studio Wall; Gallery Room; Gallery Room.
Keywords: background, bar, brick, brown, cacao, caffeine, calories, candy, chocolate, cover, delicious, design, dessert, diet, foil, front, gourmet, milk, pattern, seamless, segments, snack, square, sweet, taste, tasty, texture, tiles, torn, vector.


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Earlier this month, we blogged about a brilliant 1981 LEGO® ad that challenged the idea of girls' toys vs. boys' toys. Read the post here.
The original ad pictures child model Rachel Giordano proudly showing off her LEGO® creation. Recently, Lori Day of the Women You Should Know blog got in touch with Giordano, now an Alt-Medicine Doctor in Seattle, to reenact the scene using modern LEGOs®.
The result was quite different:
On the right, a grown-up Giordano holds the modern LEGO® Heartlake News Van, which features traditionally "girly" colors and a makeup vanity for the female reporter.
According to mashable.com, Giordano recounts:
"In 1981 Legos were 'Universal Building Sets' and that's exactly what they were…for boys and girls. Toys are supposed to foster creativity. But nowadays, it seems that a lot more toys already have messages built into them before a child even opens the pink or blue package. In 1981, Legos were simple and gender-neutral, and the creativity of the child produced the message. In 2014, it's the reverse: the toy delivers a message to the child, and this message is weirdly about gender."
Tech toy maker Goldieblox has also noted the last decade's emphasis on gender segregated toys, theorizing that manufacturers believe they'll sell twice as many toys if they position girls and boys and two separate markets.
It's difficult to determine if Giordano's childhood experience with gender-neutral toys influenced her career goals as an adult. What we do know is that when children are free to express themselves outside the confines of traditional gender roles, the world opens up for them. Creativity and innovation are for all kids. Technology is for ALL kids. The original 1981 LEGO® ad nailed it. Will our current culture ever move toward a more inclusive model for kids' toys?
We'd love to hear your thoughts–share them in the comments.


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Intex Mobile Dealers in Balasore
Intex Mobile Dealers / Showroom Information in Balasore, Orissa
We have listed information like Dealers Address, Phone Number, Customer Email id, Working Timings & Showroom Location.
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Phone No : 9338312137
Website : www.intexmobile.in/index.aspx
Timing : Monday- Saturday 9 AM – 5 PM


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First Tutors helps you to find a private medicine teacher in Bishopton and anywhere in the UK. Home medicine tuition is an excellent way to bolster confidence as well as increasing grades and doesn't have to be boring! Please use our service to find Bishopton medicine tutors and select the one who best suits your requirements.
First Tutors is the only place to discover through one search the most suitable Bishopton medicine tutors for your needs, helping you find a local Bishopton medicine teacher for any subject including GCSE English, A-Level Maths or even university Physics. We also help with language tuition, so if you want to learn Italian, take a Arabic course or prepare yourself for German life, we can help - and all in Bishopton! We order medicine Bishopton tutors in your area according to their medicine lesson costs and distance from you.
If you are a Bishopton medicine tutor wishing to offer your home medicine tuition services in Bishopton or the UK, please register with First Tutors or find out more about what we offer here. Private medicine tuition is a fantastic way to re-affirm your own medicine knowledge while helping someone else, all in the Bishopton area!


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|Start new thread in this topic | Flip this thread | Refresh the display
Is this too much?(50 Posts)
Ok, so I'm worried 8 yr old dd is doing too much. She's very keen and tends to say yes to everything and preserve with it too which is great, but I'm a bit concerned that she is going to burn out! She does a lot more than her friends too. At the moment she does brownies, swimming, choir and ballet - that's not including after school clubs. She is working towards her grade 1 ballet exam now too which involves an extra lesson every week between now and march. I'm feeling overwhelmed about the logistics of it all too which doesn't help. Am I worrying over nothing, should I just be pleased that she's so keen and willing to stick at things or should I be encouraging her to be more selective. I'd really welcome opinions.
Hi Maisie.
Not sure if this helps but I have 8yr old twin DDs & we have recently cut back on activities as they have much more homework now they're in Y3 (tap, recorders etc)
At present DTD1 does swimming, ballet and Brownies.
DTD2 does swimming, ballet and gymnastics.
Both have violin lessons during school hours.
DTD2's ballet teacher has asked if she would like to have an additional lesson each week so she can works towards her ISTD grade exams (both are working towards their Standard 2 exams) but I've left it for the moment until we get into a good homework routine...and not leave everything to the last moment!
I think we've achieved a good balance for now.
Thanks ladyenglefield. Interesting to have a comparison. Unfortunately we don't get a choice re. the extra ballet lessons. If she wants to take the exam (which she does) she has to have the extra classes. It is only for a couple of months in the run up to the exam though. Her best friend is in the same class and isn't doing the exam but she's still keen to do it despite this.
Dd is also in yr 3 and homework has increased but we do seem to manage it ok. She's very keen and doesn't need much encouragement to get it done so that's not really an issue at the moment.
We have 2 nights a week without any activities without any activities which I guess isn't too bad.
It's hard when they're so enthusiastic about things isn't it - I hate the thought of squashing that but I don't want to overstretch her.
I know how you feel, both DDs are academically hard working.
We're probably less well organised than you as I try to get them to do their homework separately. They have 2 lots of maths, literacy, spellings and 'talk homework' where we discuss a given topic and then they have to write about it later in the week.
Like you, I want to encourage them to try different activities but not to the detriment of their school work or time just to be children!
If I let them, they would want to do everything.
It's a tricky balance to strike - and you're so right about it being important for them to have time to just be children, play and relax. We've had a long chat about it with dd this afternoon. She understands the issue which is good. We're going to stick with things as they are this term but keep it under review for next term. To be honest it's the extra ballet session that is making things feel a bit manic but that is only temporary I guess.
I think the key is ensuring you have at least 1 free from activity afternoon/evening midweek.
DD is now in yr5 and had to cut back last year. She was doing something every day which was just too much, especially as she has homework every day that has to be in the next morning...
Funnily enough things have changed now anyway and she is doing much less, so actually has
Mon - School Hockey straight after school
Tue - Free
Wed - Swimming
Thur - School matches (cross country, swimming or netball) then Netball Club
Fri - Free
Sat - Free
Sun - club hockey.
She also has choir and science club but they are at lunch times so don't count.
She wants to try Karate or similar or more swimming to we are going to take a look to fit what fits in where..
My dd1, 11, does the following :
Monday: street jazz, ballet, body conditioning, contemporary
Tuesday: jazz, modern and a special student programme dance class (this is a class for children who think they want a career in dance)
Wednesday: ballet x 3 classes
Thursday: singing (and wants to add another ballet... We'll see!)
Friday: Greek, tap, song and dance
Saturday: ballet x2 classes and body conditioning
Sunday: free (unless there are group rehearsals, private lessons, workshops or auditions!)
Ds1, 7, does the following:
Monday: Ballet and street jazz
Tuesday: free
Wednesday: Greek
Thursday: free
Friday: modern, tap, song and dance
Saturday: ballet and body conditioning
Sunday: free.
Ds2, 6 has a timetable that reads
Monday: street jazz
Tuesday: free
Wednesday: Greek and ballet
Thursday: free
Friday: modern, tap, song and dance
Saturday: ballet
Sunday: free
Dd2, 4 does the following
Monday; free
Tuesday: free
Wednesday: Greek
Thursday: free
Friday: modern and song and performance
Saturday: ballet
Sounds a nightmare but when it's the holidays they are all bored! They all have homework which is always done and handed in on time to the best of their ability so I'm not worried!
Wow sparkl that lot must cost a fortune.
My DD does
Monday- Modern Dance 1hr
Tuesday- Tap dance 1hr
Wednesday- Grade 5 Ballet ( 1.5 hrs)
Friday- ballet Majors (1.5hrs)
Friday - show club dance ( 2 hrs)
Saturday- (street dance) 1hr
Sunday - Ice skating
She also does elective {PE and Dance at school- so 6 periods of physical activity there too)
There are always extra dance classes on top as she is usually working towards and exam or show- I'm glad I only have one dancing daughter- I don't think I could cope with more)
So many lifts everywhere- and the sewing!! DD has gone through 3 pairs of pointe shoes this year alone and ballet teacher insists the platform must be hand darned- no stick ons!!
I have to say my DDs school work does suffer- I have to constantly remind her about homework. I have asked her to cut back dance but she has such a passion that it seems a shame to stop. She is also sitting her ballet intermediate this year which is a vocational qualification and could form part of entrance requirements to University.
My DD (nearly 8) does nothing on Monday, Ballet and tap on Tuesday, Brownies on Weds, Drama on Thurs and swimming
Maisymoo it sounds like a lot if it's as well as after school clubs. If it was "just" swimming, choir, ballet, Brownies it would sound about right to me. A lucky girl to have such a good mix of activities.
What is she doing after school along side it? Do you think she's getting tired/grumpy/wearing self out or managing ok?
My DD (nearly 8) does nothing on Monday, Ballet and tap on Tuesday, Brownies on Weds, Drama on Thurs and swimming on a Sunday, will be 2 hrs instead of one from this term. She loves it all and never tires of any of it. I know what you mean about extra ballet lessons, she had to do extra for a few weeks prior to pre-primary and primary exams and will be doing grade 1 this summer. I think it's good to have ine or two days without structured activities otherwise it's hard to find time to see friends etc.
My rule of thumb is they should be doing something musical, something physical, and something fun that exercises their brain. And they should learn to swim and ride a bije. Anything on top is icing
prob a waste of time and money , but if they love it and are thriving in school, go for it!
So swimming, Brownies, choir and ballet doesn't sound too much on the face of things, though on top of after school clubs it might be.
It isn't cheap I must admit! Dd1 has just had her first pair of pointe shoes, and we have been warned that she will need several pairs (probably) before she takes her Interfoundation exam in the autumn!
However I work in the dance school office to offset the fees for classes.
For my children, it is a passion. I encourage it because I would rather that than them hanging around on street corners. And they have done so much with the oppurtunities that have come from the dancing.
Dd1 has tried other things over the years, ice skating, gym, archery; but it all goes by the wayside when it clashes with dance. The ice skating is probably the one she missed the most, but the rink was an hour away, and her coach wanted her more and more. He said she had potential and could have been an ice dancer, but at 5, it was just too much for her.
We went ice skating on Xmas eve, first time in at least five years, and she had retained what she learnt so that was good!
She also had ukelele and cornet lessons at school. Amazing how much you can fit in to one week really!!!
DD did 10 activities/week when she was 8.
I was knackered running around but she was fine.
Now 12yo & down to just 2 things, she says she'll quit one in August, too, hooray!
My DD is nearly 14 and does more activities than ever- still it means no time for boys!! ;))
One of the issues we have found is that what doesn't seem like too much at 8 can get very unmanageable as they get older and get better at things. Each activity grows in time as their skills grow, so you have to be prepared for them to make some hard choices along the way about what they would like to specialise in, especially if the activities are very different from each other.
badkitten I agree- as my daughter is a dancer we also have to be careful to protect from injury as she is usually working towards exams- she has to be careful and avoid risky activities like skateboarding or skiing.
Thanks. Really interesting to hear your thoughts. She doesn't get grumpy or fed up with it pickle, but she does get tired sometimes. When this happens we give something a miss as a one off, but that really doesn't happen very often.
At the moment her week is...
Mon - extra ballet lesson (exam coaching) and brownies
Tues - swimming
Weds - nothing
Thurs - choir
Fri - nothing
Sat - ballet
Sun - nothing
After school clubs vary and don't tend to run for more than a term at a time but last term it was football and gym. She's keen to take up an instrument too but that would be in school time so not too bad.
It's fairly well spread out really and hearing what others do I'm less concerned than I was...particularly you Sparkly! I don't know how you keep up! I have a soon to be 5 yr old ds too who only does swimming at the moment. I sometimes wonder how we'll juggle it once he's started doing more!
I think ours did just about nothing except what was done in schools but as private schools I suppose quite a bit was done in school.
It depends on the child really. Some want to do more than others. Our learned 2 instruments and were/ are also in school orchestras and choirs.
You do have to practice an instrument every day, however...
Ds is only in year 1 but is very sporty. I think he does too much but like yours he loves it and thrives on them! He's also very good at sport and is being picked for academies/teams etc.
his timetable this term will be:
Monday - free
Tuesday - 4pm sport 1
Wednesday - free/play date
Thursday - 4 pm sport 1, then 6:30 pm sport 2
Friday - 6pm sport 3
Saturday - free
Sunday - usually sport 3 matches, occasionally sport 1 matches
He also wants to start beavers! It's nice having the 2 free evenings though. And necessary for play dates/homework/just chilling out. Like you I don't know when it's to much.
At 8 dds schedule was something like this:
Monday : nothing
Tuesday : Tap & Modern
Wednesday :
Thursday : ballet
Friday : singing club (at scho)
Saturday : drama, dance, singing
She had piano lessons at school & did various lunchtime clubs too.
By the age of 11 this had increased to:
Monday : contemporary dance
Tuesday : Ballet, tap & modern
Wednesday : nothing
Thursday: Street dance
Friday: Drama, dance, singing
Saturday: ballet
Sunday : show rehearsals
Plus she continued piano at school & did choir at lunchtime
She's now at full time dance school!
It's reassuring to know others do/did as much if not more. In comparison to her friends she does loads and friends mums often comment how busy she is - but I'm really not forcing any of it.
I'm really pleased she has a balanced spread of things for now too - it's not all sport, dance or music but an even spread. If course I appreciate this May change as she gets older but nice to try a range of things and find where your real passion lies at this stage I think.
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Lennis Krogman
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MOVIE SYNOPSIS [ General Audiences ] Under the unique direction of G. Gotham Smith, this full movie with audio in English (original language) was premiered in 2014. The movie with dialogues written by G. Gotham Smith and Sergei Kudriavtsev, it is an original production of USA. You can watch 3.14... online on TV cable or theaters with original audio in English at different dates. This film premiered in theaters in 2014.
Rating: 5 by 11 users./
Runtime: 86 minutes
G. Gotham Smith, Jessica Tessier, Russell Rinker, Danni Lang, Matt Shallenberger, Erin Doyle, Chris Nakis, Jeffrey Ring, Nina Millin, Frank Rossi, Herrold Arres, Michael Arve, Christina Basile, Brett Begaye, Henry Begaye and Melissa Butera.
86-minute film (full movie) directed by G. Gotham Smith.
The original audio of 3.14... has dialogues in Dolby Digital, it was produced in USA.
It premiered in cinemas or television in 2014.
Screenplay written by G. Gotham Smith and Sergei Kudriavtsev.
John Vincent.
John Vincent, G. Gotham Smith, Elizabeth G. Smith and Chris Nakis.
This film was produced and / or financed by Lead Pipe Productions.
Without commercial breaks, the full movie 3.14... has a duration of 86 minutes; the official trailer can be watched in streaming on the Internet. You can watch this full movie free in EnglishDolby Digital in movie TV channels, renting the DVD or with VoD services (Video On Demand player, Hulu) and PPV (Pay Per View, Netflix).
See the page of this full movie, 3.14... in FULLTV Movies.


text:
London, April 27 (ANI): A new discovery by researchers at the Trudeau Institute may pave the way for the delivery of more effective vaccines to prevent chronic parasitic worm infections.
Dr. Markus Mohrs and his team focus much of their studies on cytokines, messengers used by cells of the immune system to communicate with one another.
Cytokines help determine both the size and the quality of our immune system's response to an infection.
How well they perform their job can decide whether it's the person or the pathogen that wins the battle for survival.
Despite their obvious importance, however, very little is known about how far or for how long cytokines can operate during an infection.
But now Mohrs' team has revealed when and where cytokine signals are received in the body.
Dr. Mohrs reports that cytokines not only signal locally to neighbouring cells, as previously thought, but they also spread throughout the affected lymph node influencing even those cells not actively involved in fighting the current infection.
The indiscriminate action of the cytokines means that these bystander cells may respond inappropriately when the immune system encounters a different infection and it becomes their turn to react.
The findings provide a potential explanation for the ability of chronic infections to alter immune responses to subsequent infections or vaccination procedures.
This is particularly important for the design of vaccines in the developing world, where chronic parasitic infections can derail vaccination programs that are effective in healthy individuals.
Because only bystander cells in the same lymph node as those responding to the parasite infection are affected by active cytokines, this study suggests that people infected with gastrointestinal worms may respond better to vaccines injected under the skin than those given by mouth.
This is critical information for the development of globally-effective vaccination strategies.
The study has appeared in the current issue of the journal Nature Immunology. (ANI)


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Tibor Fischer was born in Stockport, England, in 1959, the son of Hungarian basketball champions. He is a journalist, TV documentarian, & author of three novels, "Under the Frog" (a Booker Prize finalist), "The Thought Gang," & "The Collector Collector."
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AUSTIN, Texas -- Mack Brown and Bob Stoops have faced each other 12 times at the Cotton Bowl, with Stoops holding a 7-5 advantage in the Red River Rivalry.
But the familiar foes have gone head-to-head much more often on the recruiting trail, and each has come away with key commitments the other also was hotly pursuing.
Here are some of the most notable players that Brown was able to keep away from Stoops:
Derrick Johnson, LB
Waco, Texas/Waco
Class of 2001
Stoops had momentum on his side heading into the 2001 season. He had just led the Sooners to a national title in his second season in Norman, having beaten Texas 63-14 along the way.


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07-24-12, 09:14 #1Registered User
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Unanswered: Return values not in joined table
I'm relatively new so please ignore my ignorance and amateur skills.
Basically, I'm looking to pull back some results but not include those that have a value in a column that matches a value in a temp table column.
The below code returns all the values rather than excluding those that are in the temp table.
Any ideas?
------Folder Differences----- --Create Temp Table-- CREATE TABLE #fdiff (foldername VARCHAR(255)) SELECT replace( replace(foldername,'[Template] ','') , '[Archive Template] ','') AS Foldername FROM folderproperties FP with (nolock) WHERE domainid ='39' --Folder Differences-- SELECT dp.Domainname, dp.Domainid, fp.Foldername, fd.[foldername] FROM DomainProperties DP with (nolock) Inner join folderproperties FP with (nolock) on dp.Domainid = fp.domainid left outer join #fdiff fd with (nolock) on fp.[foldername] = fd.[foldername] WHERE NOT EXISTS (select foldername From #fdiff ) AND dp.Domainid NOT IN ('39','1','2','58') DROP TABLE #fdiff
07-24-12, 09:29 #2SQL Consultant
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SELECT dp.Domainname , dp.Domainid , fp.Foldername , fd.[foldername] FROM DomainProperties DP with (nolock) Inner join folderproperties FP with (nolock) on fp.domainid = dp.Domainid left outer join #fdiff fd with (nolock) on fd.[foldername] = fp.[foldername] WHERE dp.Domainid NOT IN ('39','1','2','58') AND fd.[foldername] IS NULLrudy.ca | @rudydotca
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07-24-12, 10:02 #3Registered User
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I've realised (after several hours of me looking blankly at my screen) that I forgot to put 'insert into' into my temp table.
Really love it when I miss the simplest things!!


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The fact of the matter is that this persons parents broke the law by jumping in line with him in front of all the other people who've been legally waiting in line ahead of them to become legal citizens. It doesn't matter how long he or they've been here, they need to be removed from the line and forced to the back of the line behind those ahead of them that are doing it legally. It's really that simple.I have a friend who is in the final stage of getting his green card - one more hearing, I believe. He was brought here by his parents from Peru when he was 5. He just turned 42. He was unaware he was illegally residing until he tried to apply for his driving permit at 16 and his parents told him the story. He finished high school and learned various trades, having no problem getting odd jobs for cash for a couple of years. In his early twenties he married a legal resident. From then on when he took jobs, he had them pay him in checks made out to his wife so she could pay the taxes and put into Social Security. He still can't get a license, so she has to drive him to his jobs. His children are nearly grown and have real jobs - one at a mall store and the other is starting her own tailoring business.
So, he has been working on getting his green card for over 15 years knowing he could have been deported at any time to a country he never knew. They worked hard - never applied for any assistance - just wanted to be normal Americans.
This is similar to those cases that Sam is making reference to, but I think he is referring to the 'dreamers'- the ones in their late teens and early twenties who are just realizing the impact of their being here illegally. There are many high school grads in this boat that are waiting to find out what's in store for them. They thought they had their wholes lives to look forward to here and now they're facing deportation.
Most undocumenteds in states other than southern border states are not Mexican. It's really easy to enter legally and overstay a visitor or student visa. You don't have to scale a fence to get in.
Immigration laws tear families apart
There are 435 comments on the Worcester Telegram & Gazette story from May 25, 2013, titled Immigration laws tear families apart. In it, Worcester Telegram & Gazette reports that:
Miguel Leal of Fitchburg and six others had the full attention of President Barack Obama and Vice President Joseph Biden in the Oval Office on Tuesday.
Join the discussion below, or Read more at Worcester Telegram & Gazette.
#279 Jun 14, 2013
#280 Jun 14, 2013
Sam we are a country of laws. In your view some laws can be broken. I'm sure bank robbers, car thieves and drug dealers dislike the laws against them but these are the laws. What don't you understand about ILLEGAL?
#281 Jun 14, 2013
The idea of his employer paying the wife for a job that he does is mind boggling! and maybe not legal either! what a way to live only because the parents illegally brought him here. His misery is their doing and at his age how is it that he is in the final stage of getting his card? having been here working and having his wife get his pay? doesn't seem feasible. His parents no doubt are still here, illegally.
#282 Jun 14, 2013
Micmac, that is indeed similar and I am talking about the late teen post graduates.
Some of them are even told to leave so that they can be done "properly," only to find that those proper rights have been removed for the rest of their lives. This, in exchange for listening to the federal agents.
#283 Jun 14, 2013
Being locked and barred in a foreign country away from loved ones through no action of your own is a greater misery then the "mind boggling" one here IMO.
#284 Jun 14, 2013
Illegal IS Illegal no matter what the government tries to call it!
They deserve NOTHING but deportation!
#285 Jun 14, 2013
That may be good and well for the parents breaking the law;
those parents should also receive additional penalties depending on their case,
but the kids are also punished by having their rights to normal entry removed, leaving them effectively "exiled" as normal law-observing citizens based on nothing they've committed.
#286 Jun 15, 2013
Micmac if it is taking over 15 years for your friend to get a green card he may want to find a better immigration lawyer.
#289 Jun 15, 2013
By "sort of American" I mean that they try to obide by laws and have not willingly broken any (their parents did, but they have not). I also mean that they grew up in America and they believe in America and US Law.
This is a trait that people who haven't visited the US regularly or others who haven't been forced into the country likely do not share and US intelligence, history, and faith, is a strong characteristical trait to have when it is known that these people haven't chosen to violate the law.
Under the right circumstances, that might be usable for positions where such traits are necessary, such as "line-of-fire" military situations where blind faith is necessary by the platoon.
In areas where there is a shortage of legally documented Americans,
this "sort of American" quality (with everything there, except paperwork), could be taken advantage of to further American interests worldwide, on the battlefield.
There would also be a push towards increasing administrative positions for people that hold paperwork in America, to command these types of "dreamers."
#290 Jun 15, 2013
He has had several. When you are here illegally (even after 37 years) it is easy to be taken advantage of. He is unaware of his parents' status and location. When he found out about his his illegal status, he was so angry at them that he left their home and made his own way living under the radar all these years.
"Liberal Teachers ruin Kids"
Since: Mar 09
Paradise Valley Arizona
#292 Jun 15, 2013
The actual cost of illegal immigration could be as much as $400 Billion tax dollars.
We as Americans must just say NO!!!
#293 Jun 15, 2013
We were discussing kids that get taken over and immediately report to recruiters and government agencies.
They get sent away and cannot "enter the US legally" under "normal" circumstances. If they report to the government, they are and will be labeled a criminal and their normal entry rights removed; this is before they've done anything.
They get effectively punished for observing the law.
There is little reason to leave and be restricted by the law when you've done nothing wrong (if you really are aware what will happen to you).
Staying and hiding seems logical when the alternative is being forcefully kept from the people you love.
"Work hard at work worth doing."
Since: Apr 11
Location hidden
#294 Jun 15, 2013
Nope, not exactly. I know many of these kids who were brought in when they were kids who have reached the "legal" age of driving....and driving they are...without a license or insurance because they have no papers. To make matters worse, they must be emulating their dads, as they also are drinking and driving. You see, they have learned from the example their parents set forth for them. Don't try to sugarcoat it, you can't.
#295 Jun 15, 2013
People shouldn't drink and drive. That includes "Americans."
(and insurance companies should protect the person paying them insurance money IMO)
When undocumented people choose to disobey the law,
they are acting as anyone else choosing to disobey the law.
Targeting only the undocumented drunk drivers,
ignoring documented drunk drivers,
and then telling others that are undocumented,
who don't drink or drive,
that they are guilty of that crime as well,
isn't correct.
I can understand that anyone that experiences a drunk driver who is undocumented, may have extended difficulties with financial security, but that issue lies with the way insurance companies work.
A broke American driver with absolutely nothing (including a license), that is drunk and causes someone injury, is going to provide similar complications.
It is not the fault of all undocumented people that someone drank alcohol and stepped in a car without a license.
"Work hard at work worth doing."
Since: Apr 11
Location hidden
#296 Jun 15, 2013
You are truly laughable.
#297 Jun 15, 2013
In regards to illegal aliens doing it, among other crimes, it is more that they are not supposed to be here in the first place so if law enforcement was allowed to do their jobs by the government then those particular crimes would not have taken place because the illegal alien would not have been here to do it. Of course a legal immigrant or an American does the same thing but the point being people who are here illegally and basically being harbored here are doing it too and it need not be that way.
Case and point. Let us say that an American hits your car and is drunk. No injuries but the drunk goes to jail, is justly punished by prison, fines, and or probation. If they have insurance then you are taken care of. If not then you or your insurance can sue the drunk for your losses. Any personal assetts or wages can be taken through the courts for your loss.
With an illegal alien that is not possible as either they move to another town, back over the border, or since they have no ID they cannot be traced once they are released from jail. ICE is not notified by local law enforcement in most cases, even if that city is not a Sanctuary City. If ICE is notified and deports the illegal alien you are still out of luck, as is your insurance company who will cover your loss, raise your premiums and that of other policy holders. All this for someone who was not supposed to be in the country in the first place.
If the illegal alien is injured then taxpayers pay the bill while if you are injured you get the bill.
#298 Jun 15, 2013
Hi Austinite,
Not all "illegal aliens" are here by choice. Some where taken here when they are little and when they find that out, they are mad and they want to listen to the law.
Those people shouldn't be driving unless the law is fixed.
If you hit an American with no money and no insurance or license,
then you will not get much or any money.
#299 Jun 15, 2013
I try.
#301 Jun 15, 2013
The law is not broken, it is just not enforced or not enforced much.
Illegal aliens brought here as children know later as teens or adults their status and need to leave the country and get in line to legally enter. Instead of knowingly breaking other laws while staying here, illegally.
You missed the entire meaning of my post anyways.
"Work hard at work worth doing."
Since: Apr 11
Location hidden
#302 Jun 15, 2013
You try to justify the actions os those who should not be here, whether they came on their own, or were brought here by their parents. They should be the ones rectifying their status; our government should not even be considering gifting them with the right to remain without imposing heavy fines and substantial back tax repayment. The taxpayers seem to get stuck propping them up at every turn of the corner, and our focus should be on helping get our own people back to work and off the government teat...period. There is no justification for illegal behaviot period, no matter who commits the infractions.
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The International Cricket Council has cleared Calcutta's Eden Gardens and Wankhede Stadium in Mumbai to be used for three World Cup matches as scheduled.
Tournament director Ratnakar Shetty confirmed to The Associated Press via text message that organizers had got a go-ahead for the two venues, which had been slow in renovation work.
The Eden Gardens had lost its marquee match between India and England on Feb. 27, but will host three other games — South Africa vs. Ireland on March 15, Ireland vs. Netherlands on March 18 and Zimbabwe vs. Kenya on March 20.
Mumbai, which hosts the final on April 2, apart from Canada vs. New Zealand on March 13 and New Zealand vs. Sri Lanka on March 18, had a provisional clearance.


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Sprint will begin taking pre-orders for the new LG G2 Android 4.2 smartphone on their network starting on October 11th. The handset will retail for $199.99 with a new-two year contract agreement. To refresh your memory, the LG G2 sports a 5.2-inch 1080p Full HD IPS+ touchscreen display, a 2.3GHz quad-core Qualcomm Snapdragon 800 processor, a 2GB RAM, a 16GB/32GB of internal storage, a microSD card slot, dual cameras (2.1MP front & 13MP rear), NFC, LTE connectivity, a 3000mAh battery and runs on Android 4.2.2 Jelly Bean OS. [Press Release]
LG G2 To Be Available For Pre-Order At Sprint On October 11th
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for a new job. Here are a few pictures
for a new job. Here are a few pictures
I have a crowd-funding campaign to publish my short-story collection, The Alchemist's Grandson Changes His Name. Check it out.
I think Emerson said that nature balances living beings' character and abilities. Consider the shark. Small ones are vicious while the 20-foot whale shark eats only plankton. Aggressiveness and the ability to cause mayhem tend to balance. Fortunately, the same holds true with people. I've known several 200-pound weightlifter types but all had sweet dispositions.
I suggest keeping this in mind when naming a dog. Balance the name's machismo the viciousness of the breed. Attila the Corgi and Cuddles the Pit Bull would be in harmony while Daisy the Yorkie or Heinrich the Doberman would not.
The Journal of Humanistic Mathematics published my article on the statistics of submitting poems and stories to small-press journals. To download a copy go here.
I hope I'm wrong,
so wrong my name becomes slang
for a tragic blunder
as in, "Custer sure pulled a Wesick
at the Little Bighorn!"
I hope jobs return to the rust belt
and displaced workers
will now buy gold-plated mansions
and endow professorships at Harvard.
I hope the new president's tweets
scare the beards off ISIS
and that from now on all terrorists
will come with big letter T's
tattooed on their foreheads.
I hope greenhouse gasses
bring back the black rhino
and mountain gorilla.
I hope charter schools
turn out so many 14-year-old Ph.Ds.
that the Nobel committee goes bankrupt
from awarding all the prizes.
I hope the free market
lowers the cost of heart transplants
and cancer treatment to $1.95.
I hope doctors determine cake and ice cream
make the most nutritious breakfast
and that playing video games
burns more calories than running.
I hope high school students don't need algebra
for high-tech careers and that cheerleaders
want to sleep with guys who can't dance.
I hope I really can earn $100,000
by working 3 hours a week from home.
I hope our new president
rekindles the American dream.
This poem previously appeared on the New Verse News website.


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