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Natural convection
Báo cáo hóa học: " Mixed convective boundary layer flow over a vertical wedge embedded in a porous medium saturated with a nanofluid: Natural Convection Dominated Regime"
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Mixed convective boundary layer flow over a vertical wedge embedded in a porous medium saturated with a nanofluid: Natural Convection Dominated Regime
9p sting05 09-02-2012 46 5 Download
Heat transfer has emerged as a central discipline in contemporary engineering science. The research activity of a few decades ago—the material reviewed in the first handbooks—has distilled itself into textbook concepts and results. Heat transfer has become not only a self-standing discipline in the current literature and engineering curricula, but also an indispensable discipline at the interface with other pivotal and older disciplines.
0p 123859674 30-06-2012 77 19 Download
In smaller regions such as the Carpathian Basin (located in Eastern/Central Europe), 50 km horizontal resolution may still not be appropriate to describe the meso-scale processes (e.g., cloud formation and convective precipitation). For this purpose on a national level several RCMs have been adapted with finer resolution (25 and 10 km). Here, results from two of the adapted RCMs for Hungary are analyzed, namely, models PRECIS and RegCM. In this paper, first, data and models from PRUDENCE, PRECIS and RegCM are presented.
290p lulaula 25-10-2012 31 17 Download
CHAPTER 54 COOLING ELECTRONIC EQUIPMENT Allan Kraus Allan D. Kraus Associates Aurora, Ohio 54.1 THERMAL MODELING 54. 1 . 1 Introduction 54. 1 .2 Conduction Heat Transfer 54.1.3 Convective Heat Transfer 54.1.4 Radiative Heat Transfer 54.1.5 Chip Module Thermal Resistances HEAT-TRANSFER CORRELATIONS FOR ELECTRONIC EQUIPMENT COOLING 54.2.1 Natural Convection in Confined Spaces 1649 1 649 54.3 1649 1652 1655 1656 54.2.2 Forced Convection 1662 1667 1672 1672 1674 THERMAL CONTROL TECHNIQUES 54.3.1 Extended Surface and Heat Sinks 54.3.2 The Cold Plate 54.3.3 Thermoelectric Coolers 54.
31p hadalabo 29-09-2010 44 7 Download
Oueslati and Bennacer Nanoscale Research Letters 2011, 6:222 http://www.nanoscalereslett.com/content/6/1/222 NANO EXPRESS Open Access Heterogeneous nanofluids: natural convection heat transfer enhancement Fakhreddine Segni Oueslati1, Rachid Bennacer2* Abstract Convective heat transfer using different nanofluid types is investigated. The domain is differentially heated and nanofluids are treated as heterogeneous mixtures with weak solutal diffusivity and possible Soret separation.
11p dauphong13 09-02-2012 31 4 Download
Báo cáo " AN IMPLICIT SCHEME FOR INCOMPRESSIBLE FLOW COMPUTATION WITH ARTIFICIAL COMPRESSIBILITY METHOD "
To simulate the incompressible flow in complex three-dimensional geometry efficiently and accurately, a solver based on solution of the Navier-Stokes equations in the generalized curvilinear coordinate system was developed. The system of equations in three-dimension are solved simultaneously by the artificial compressibility method. The convective terms are differenced using a flux difference splitting approach. The viscous terms are differenced using second-order accurate central differences. An implicit line relaxation scheme is employed to solve the numerical system of equations.
13p tuanlocmuido 19-12-2012 30 3 Download
When unfired units are designed with higher steam conditions for combined cycle, multiple-pressure units are usually applied to increase exhaust heat recovery and enhance system performanc The intermediate level may be that required for steam injection fo NOx control and/or a process level. In applications using natural gas, a third pressure level will further enhance overall system performance. Typical design practice is that unfired HRSGs are convective heat exchangers that respond to the exhaust conditions of the gas turbine.
27p loixinloi 08-05-2013 18 2 Download


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View other listings in Windsor, South Yarra, Richmond, Prahran, Saint Kilda.
Online over 1 year ago
Rent budget
Preferred stay length
Move date
I'm Kirstie, 24 from England, currently looking for a place until December.
I'm easy going and an experienced house sharer who respects living with others. I love to socialise at the weekend and enjoy the odd wine or dinner during the week.
I'm in Melbourne until the start of December so would be looking for something up to then.
I love to salsa dance and dancing in general and always down for a goid boogie and a vino.

subset: commoncrawl


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- Please select a date to see the proper prices!
- Meal can be requested on the spot
Best offer
59 € / person / night, no meal
Description of the accommodation:
Rooms, services Hotel Karwendel Innsbruck is offering 70 nicely furnished rooms to stay in to those seeking accommodation in Innsbruck. Parking is availably nearby for those arriving by car. Nearby bike rental and minigolf opportunities will provide an excellent chance to spend your leisure time actively. The bar can be an ideal place for a pleasant evening talk or a meeting. At the hotel you may go online via wireless Internet connection (WiFi). To learn more about the exact range of services of Hotel Karwendel Innsbruck (including services for an extra fee) and the exact equipment of the rooms, please check the information sheet below.
Payment Depending on the selected date, room and price, you may need to provide credit card guarantee or advance bank card payment to finalize your reservation.
Arrival, opening hours The earliest check-in time is 14:00, the latest check-out time is 10:00. You will be able to speak with the personnel in English and German languages.
Hotel Karwendel Innsbruck rooms Rooms
- Please select a date to see the proper prices!
Accommodation services
Parking (5 €/night)
Free WiFi in shared places
Minigolf, Bike rental at the accommodation
Pet friendly (5 €/night), Bar, Elevator
Desk in the room


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Dan Bristol
English (North American), English
North American
Child, Middle Aged, Senior, Teen, Young Adult
Special Skills
Audiobooks, Business, Cartoons, Documentaries, Educational, Internet, Jingles, Movie Trailers, Music, Podcasting, Telephone, Television, Videogames
I sang in a rock band from the age of 13 until shortly after I turned 21 years old. I really learned how to control my voice during this time and to treat it like an instrument. After that time, I did some voice over work for student film projects.
Payment Terms
Hire Dan as a voice actor. Payment is made through Voices.com SurePay, an escrow service that guarantees your work is done to your satisfaction. Send payment securely by Visa, Mastercard or PayPal through Voices.com then download your files from the website.
Watch a video to see how to make a payment
Next Steps
To contact Dan Bristol about your project, request a quote today. We'll walk you through the process step-by-step. It's fast and easy.
This talent has not uploaded any demos yet.
Hire Dan Bristol as a voice actor. Working with Dan Bristol is fast and easy. We'll walk you through the process step-by-step.
Request a quote for your project today.


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Over the past year, Civilized Living, produced by Fancy Tiger boutique, has established itself as one of the most stylish events of South Broadway's First Friday art walk. Tonight the store will launch a new version, called Modern Tiger, in which Mod Livin', an East Colfax furniture store, will display its wares inside Fancy Tiger for the month. In exchange, Fancy Tiger will establish a pop-up shop inside Mod Livin'.
"I like what they're doing. I love their style; I love modern design," says Fancy Tiger owner Matthew Brown of Mod Livin'. "They're going to be putting four pieces of furniture in the store that will all be for sale -- and as they sell, we'll refresh them. And then, in their store, I'm going to do a small display of products from Wheelmen & Co., a California-based company doing these really amazing fashionable backpacks and tote bags, as well as the candles that I make in-house.
"We were curious what it would be like to have a presence on East Colfax in a different market," Brown adds. "We really love the idea of dipping our toe in that market. It's a little more 'auteur' than South Broadway feels."
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The Modern Tiger launch runs from 7 to 10 p.m. at Fancy Tiger Clothing, 55 Broadway, with beers from Breckenridge Brewery and Pabst, and a DJ spinning tunes. For more information, visit fancytiger.com.
Fri., July 5, 7-10 p.m., 2013


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Swap Meet
- Artist: Gold Standard
- Format: CD
- Release Date: 6/6/2006
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Gold Standard's particular brand of funked-up Jazz groove rock may be new to festivals and clubs of the midwest, but any devotee of 1970s horn bands like Average White Band and Chicago will recognize the influences immediately. At least they'll think they do, until the song takes a hard left turn and plunges haphazardly through the depths of vintage prog-rock while guitar or sax take a blazing solo flight, pushing the band to ever greater heights of volume and intensity before arriving breathlessly, but safely, at the hooky sing-along chorus. After a scant two years together as a band, Gold Standard has crafted a slick, unique style that is as instantly recognizable as it is infectious, and their debut album 'Swap Meet' deftly captures the essence of their myriad talent and compresses it into a highly listenable, always changing musical experience.


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We're here to help - take a loot at some of our most frequently asked questions about the Show...
Friday & Saturday: 9.30am – 5.30pm
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Standard Adult advance tickets are - £19 (£20.50 on Saturday). For full ticket prices, please information.
Prices detailed are subject to change.
You can contact The Ticket Factory by filling in the form here or by calling them on 0333 300 3010.
Please have ready the email address or name you booked under or your order number if you have it.
The fulfilment fee is charged per order, not related to the number of tickets purchased. Fulfilment fees are not applicable to orders of only additional 'add-ons', such as theatre sessions added to your booking at a later date.
The Fulfilment Fee contributes to the cost of delivering the tickets, whether it is through the post, electronically or collecting at the venue. The fulfilment fee also contributes to other operational costs and overheads associated with ticket fulfilment e.g. ticket stock administration and inventory control, ticket stock/stationery, collection facilities and postage and/or packaging costs.
Children aged 0 – 5 are free every day but should sit on an adult's lap in the Supertheatre. If a Supertheatre seat is required a ticket must be purchased by calling 0844 581 1358. Children aged 6 – 17 are charged at the child rate (Sunday only £5.50 or £8.50 Gold). Please click here for all ticket prices.
Under 18s are admitted to the Show accompanied by an adult. In accordance with the law, visitors aged under 18 are not permitted to purchase/sample alcoholic drink products or knives. It is the attending adult's responsibility to ensure visitors aged under 18 are aware and comply with these laws for the duration of their visit to the Show.
Children under 12 are not permitted to attend the Show as VIP's.
'Super' tickets and VIP tickets include a seat in the Supertheatre.
Supertheatre seating is available for disabled visitors or visitors with special requirements. Visitors should book these theatre seats by calling the Box Office to ensure the best possible seating arrangements. Please call the Box office and explain you require disabled or special assistance seating and they will be able to ensure this is arranged. The Ticket Factory can be contacted on 0844 338 0338. Calls cost 7p per minute plus your phone company's access charge. Lines are open from 8am to 10pm, seven days a week.
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If you selected a print at home ticket you should receive these by email straight away. If you opt for tickets to be sent by post, they should arrive no later than 2 weeks before the Show. If you book within 1 week of the Show, you must collect tickets from the Box Office or select Print at Home tickets.
Groups of eight or more get discounted tickets based on the size of the group, and benefit from FREE organiser tickets too. A group starts from just 8 people. Click for or call 0800 358 0058.
School groups are not permitted at the Show, on any day. Please note, if group tickets are purchased for a school they will be turned away on arrival at the Show.
Yes. Tickets are available on the door, but do cost more than advance tickets. To avoid disappointment and to get the best choice of Supertheatre seat book in advance – and it's cheaper! Supertheatre seats are subject to availability on the day.
HIC has its own underground car park with around 158 spaces. You will also find a further 1,200 spaces at the nearby Jubilee and Victoria car parks. Please note that the Jubilee car park is the nearest to the entrance of our event as well as the easiest for disabled access. Costs for HIC underground car park:
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For more information about the venue please visit www.hicyorkshire.co.uk.
The venue is unable to offer wheelchair hire, however if you are unable to bring your own wheelchair or mobility scooter to HIC Yorkshire, please contact Shopmobility Harrogate (01423 556778) or Able to Enable (01423880882) who will be happy to help you.
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We highly advise you purchase your books onsite at the event to ensure they get signed.
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All Four Cores were briefly online this week before Brandon exploded in a blaze of 8-bit glory after being attacked by the Krampus. We shall miss him.
We chat about the things left in 2015 that we are most looking forward to, debate Disney's newfound love of making live action remakes of their animated classics, talk about Gen*Con, the upcoming Samsung Galaxy Note 5, and Jurassic World's ever-bigger box office take.
Come join us for fun and whimsy on episode 26!
Core Reactors: Brandon Smith (briefly), Marty Estes, Michael Burgett, Jared Wallin
Podcast: Play in new window | Download


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Mother, fitness/health blogger, and nutrition coach, Joanne Encarnacion, better known as GOFITJO, is balancing it all and just recently added one more thing to her plate. Between raising two daughters, balancing a healthy lifestyle, and sharing her fitness/health journey with us through social media and her blog, Joanne recently launched her latest undertaking: a totally free (yes you read that right, free!) recipe and food-prepping guide. From meal-prepping tips to what you should be buying at the grocery store, Joanne's guide shares a collection of her favorite go-to healthy recipes. We were so excited when we heard about this, so we caught up with Joanne to ask her a few juicy questions all about her guide!
GoFitJo Talks With Us About Her New (and Free) Recipe + Food Prep Guide
WW: What was the inspiration for creating GoFitEats? Was there a demand from your readers who were inspired by your journey into a healthier lifestyle?
GFJ: I wanted to create an easy guide for people to use when it came to some of my recipes that I share on Instagram or my blog. I would often get questions about meal prepping or healthy eating because I'm a busy career mom who loves simple, healthy, and no fuss meals that I can enjoy and my family can enjoy too. I think there will always be a demand on finding inspiring ways to eat healthy not just from my readers but from everyone in general, so yes I would say there was a quiet rumbling demand for one.
WW: We love all of the recipes that are included in GoFitEats! Which one is your favorite go to meal?
GFJ: I think my favorite go to meal is the simple ground bison that I turn into a bison bowl like I suggest in the recipe guide. It's a great dish to prep and serve on top of others for a healthy dose of lean protein. I often times have the bison and quinoa together topped with an egg for breakfast for a protein packed meal before my workout or post workout.
WW: Last year our company, WiseWear, gifted you the Duchess from the Socialite Collection. As well as tracking activity, the Duchess counts calories. Do you find this feature to be helpful when planning meals throughout the day?
GFJ: I rarely count calories these days since I focus more on intuitive eating. However I think in the days where I used to it probably would've been an amazing tool to have. I'm a huge fan of intuitive eating because listening to our bodies has become a lost ancient art.
WW: We know instead of cheat meals that you call them victory meals. So when you indulge in a victory meal what does it consist of? Do you prefer something sweet or savory?
GFJ: I'm a huge fan of both. I love me a really good burger or a meal high in protein like pork chops or a steak that I didn't make. After that victory meal I'll need some sort of sweet to balance it out. Sometimes a kid sized gelato or frozen yogurt does the trick!
WW: How do you stay organized while prepping your meals? Is their any advice for people looking to do the same thing?
GFJ: I'm pretty nerdy when it comes to organizing my fitness and my meal plan. I typically use a program called My Fitness Pal to create my menus for the week, I don't fully track macros since I don't have any specific goals in mind but I do like to pay attention to my body and listen to the queues. So providing myself a little structure helps me to understand what sort of carbs or proteins don't do well for me in that week. Then I import that entire PDF into an app called Evernote so I can sync it across my devices along with my weight training splits. It's a little OCD, but totally works for me. When it comes to meal prepping I like to cook all my proteins using one heat source. For example if I'm baking fish, then I''ll bake or roast my veggies along with it. If I'm using the grill, it'll be grilled veggies for me that week. It helps me keep meal prepping enjoyable by not having so many pots or pans to clean up. After that I line up all my meal prep containers and its like an assembly line measuring things out and packing it up.
WW: Where did you come up with the rules in the GoFitEats guide? We especially love Rule #1!
GFJ: These were my own rules to live by the moment I learned how to balance out my dedication to my fitness goals when I was competing to then living a balance and normal none athlete lifestyle. Rule #1 is also my favorite because I think we forget to enjoy life when we become so focused on a fitness goal or perfecting the week by checking off all the clean meals or the workouts we need to accomplish. There's so much pressure around showing others we're working hard towards our goals when in reality we need to be proving that hard work to ourselves.
WW: Are any of the meals in the GoFitEats guide inspired by your Filipino roots?
GFJ: Not in this one, but I do need to share my chicken adobo. Maybe that'll be in an upcoming guide!
WW: Do you incorporate any of your mother's cooking techniques when creating your meals?
GFJ: I incorporate them when cooking Filipino dishes. My mom only cooked Filipino food so she wasn't one who grilled, baked, or roasted her dishes. We ate a lot of protein based stews, rice dishes, and fried foods.
WW: What are some of the challenges you face when meal prepping?
GFJ: Let's be real, boredom. Some days I'm really kicking myself in the butt for having to eat the same set of meals for 7 days straight. So what I started to do was meal prep twice a week, on Sunday and on Wednesday. This helped me stick to the same macros and main ingredients while switching up the flavors and seasonings.
WW: The GoFitEats guide encourages readers to plan ahead and prepare meals for the upcoming week. What if some readers cannot prepare ahead or forget to take a meal with them if they are out of the house. Do you have any advice for eating healthy when out running errands or traveling?
GFJ: My favorite "oh crap I forget to pack my meals" place to eat is Chipotle, I can always get burrito bowl and half them ease up on the carbs so I can stick closely to the menus I've created. Another little life hack would be to simply pack some almonds in your bag or in your car. Raw almonds are such a great source of healthy fats and protein that can help to keep you satiated throughout your busy day. If you're traveling and in an airport, try to go for the fresh stuff rather than anything that comes in a package. I know that might be challenging and cost a fortune, but your health is wealth. If you invest in yourself in little increments like choosing a healthier salad option over a bag of chips then in the long run you might save yourself a buck or two when it comes to medical bills.
WW: We love the section Spice It Up in the meal planning guide! (The Hawaiian Marinade sounds especially tasty). Which one is your favorite? Is there a favorite among your family?
GFJ: The Hawaiian Marinade is a family favorite and personal favorite. We love that marinade on everything. The other might be the lemon one because you can add any other sauces on top of your protein to flavor it a little differently.
WW: For those reluctant to take the plunge into meal planning/prep (or those who just think they don't have the time or patience for meal planning) what words of inspiration or encouragement can you offer them?
GFJ: I would say just try it for a week. You don't need to commit to it for a lifetime and do what works for you. Some weeks I only prep two meals for 3 days because I know I've got a busy social calendar which requires me to dine out. I rarely have a fear of pulling out my tupperware in public but somedays I want to eat on a plate just like the rest of the group.
WW: We would love to know what you're currently working on and what we can expect to see from GoFitJo in the future?
GFJ: You can expect me to build out more video content library on my YouTube channel and take 1 on 1 clients for holistic health and nutrition coaching. I'm hoping that by 2018 I'll be gearing up to start hosting wellness retreats both in CA and in Hawaii, mainly Hawaii.


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Make Room for Her
Amazon »
Barnes & Noble »
It's Not A Glass Ceiling, It's A Sticky Floor
Leadership Secrets of Hillary Clinton
Today's successful and thriving companies will have or are striving for gender balanced leadership because it's a smart business thing to do. Even so we are not there yet!
Attend SHAMBAUGH's Women in Leadership and Learning Program. »
Increase the effectiveness of your leaders and improve business results. »
Copyright © 2017 SHAMBAUGH Leadership


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Skip Navigation | Translation
FSU Home → Career Services → Students → Undecided
Unsure about what you want to do? Undecided as to where you want to go? The first step in any Career Plan is determining: What's your destination?
O*NET Interest Profiler: A fantastic and FREE resource provided by the US Department of Labor. You simply answer a few basic questions and it will provide a personalized job report with information about various jobs, salaries, education level requirements, and state specific outlooks for future opportunities in the field.
Focus 2: Similar to the above resource, it is university sponsored resource which gives additional insights to individual personality and work interests.
My Next Move: "Search by Keyword" or "Browse by Industry", also US DOL sponsored site with additional quick info job reports on specific careers. The Browse by Industry feature is really helpful to get additional ideas of job titles related by industry/discipline.
My Next Move: for Veterans: Allows the same "searchability" as regular O*NET resources, but provides specific areas for branch and MOS designations to pull even more specialized job reports.
STEP 2) How do you get there?
What types and level of education will be required for your chosen career? Will you need an Associates', Bachelor's, Master's, Doctorate or no degree at all? Professional( i.e.: JD, PharmD, DPT) or Acadmeic degree programs (PhD)? How many and what kinds?
Major Exploration: What Can I Do With This MajorInternshipsMy Next Move: "Search by Keyword: To see individualized job report showing minimum level or education usually need for specific jobs.Career Resource Guide
STEP 3) Getting your first "professional" job.
Now that you know what you want to do, you've completed a course of study with some helpful internships where you gained real world, firsthand knowledge of the benefits and challenges involved in your chosen profession, how do you land your first "real" gig?
Handshake: Career Management Database, outstanding system listing thousands of employers specifically seeking FSU students. This is where you will find listings for Internships, Career Fairs, on Campus Employer Events, etc...InternshipsCareer Resource GuideInterview Stream
Goals for the Year
Click here for complete list


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Budget 2013: As P Chidambaram walks the talk, 5.3% fiscal deficit target may be met
NEW DELHI: When finance minister P Chidambaram said in October last year that he would limit fiscal deficit to 5.3% of GDP, only his ardent supporters gave him some chance of meeting the stiff target.
The young crop of economists had laughed it off with targets of 5.8% and some even 6%.
Barely three months later, Chidambaram has converted many doubting Thomases with credible action on fuel prices, relentless chipping away at expenditure and desperate search for revenues, an effort that showed up in December-end numbers.
In the last few days, several brokerages have cautiously put out reports that say the 5.3% target is achievable, albeit with some caveats, while international rating agencies, which had threatened downgrades, have softened their tone.
"In contrast to trends a few months ago, we now think this (5.3% of GDP) could be achieved," wrote Citi economist Rohini Malkani in a note on Monday, adding that the success of disinvestment programme and spectrum auction will be crucial.
HDFC Bank expects slippage on tax collections and spectrum proceeds and higher subsidy burden than 1.9 lakh crore provided in the budget, but feels reduction in expenditure and higher dividends from state-run companies will help keep deficit at 5.3% of GDP.
"The target is well within reach," a senior finance ministry official told ET.
The budget presented by the then finance minister Pranab Mukherjee in March last year had been panned by experts for optimistic revenue assumptions and under-provided subsidies.
Against a budgeted fiscal deficit of 5.1% of GDP, most private estimates had pegged the deficit at near 6% of GDP. That fiscal deficit for the year 2011-12 was 1.8% points higher than budgeted 4.1% of the GDP, did further damage to the credibility of government's estimates.
After taking over as finance minister in August last year, Chidambaram had set up a committee under Vijay Kelkar to suggest a fiscal consolidation plan, and based on that announced a revised fiscal deficit target of 5.3% of GDP for the current fiscal year and a roadmap to bring it down to 3% of GDP in 2016-17.
He backed that promise with increase in price of diesel, a cap on the number of subsidied cooking gas cylinders and a massive cut in plan expenditure. "This (5.3% fiscal deficit) would have appeared unrealistic just a few months ago, but the recent fuel price decisions and expenditure data are encouraging," wrote Taimur Baig and Kaushik Das of Deutsche Bank, in a recent report.
"If the government slashes plan expenditure by 28% in FY13, as reported in the media, and postpones subsidy payments, then the revised fiscal deficit target (5.3% of GDP) will be in the realms of possibility with a chance of even under-shooting it," said Nomura's Sonal Varma and Aman Mohunta in a note last week.
The government has run up a fiscal deficit of 78.8% of budget estimates, against 80.4% in December, suggesting a marginal saving in December because of sharp expenditure cuts and massive attempts to shore up tax revenues. The finance ministry has issued warnings to taxpayers to come clean, holding out the threat of prosecution, and asked the tax administration to go all out to raise revenues, even as it has applied an expenditure squeeze on ministries, with some facing up to 30% cut in allocations.
Plan expenditure stood at 56.8% of the budget estimates in April-December period of 2012-13, compared with 62.7% in the previous fiscal and has risen only 6.9% as against budget rate of 22.1%.
Since ministries and departments cannot spend more than 33% of the allocation in the last quarter, there is likely to be substantial saving on plan spending.
HDFC Bank expects expenditure reduction of about 1 lakh crore in the current fiscal. Rating agencies that have put India's barely investment-grade rating on watch have also softened their view of late. "Public commitments and policy announcements by the Indian government so far in 2013 are encouraging signals that the authorities want to maintain the momentum towards fiscal consolidation and structural reform generated since last summer," Fitch Ratings said on Monday.
However, the massive squeeze has raised concerns over the quality of fiscal consolidation. "Compromising on growth-critical spending is not helpful for the economy, especially when private investment is anemic," say Taimur Baig and Kaushik Das.


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shes your classmate and you havent gotten a blowjob yet......yea we see where your lifes going lolol
two thumbs up for that cutie !! im gonna look her up when I go next fall
Wow. I want to marry her. Great body, lovely nipples, sexy pussy and arse. I love the way her tongue goes exploring around his arse, under his balls, and all along the shaft. This nearly made me cum before she got to fucking. She would be a really hot fuck
She almost vomited when the cumshot landed on her face...oh well, I knew she did it for the money and not for pleasure :-)
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We operate in Norway and Poland
Clients in 15 different countries
Offices in Moss, Oslo and Gdansk
Number of employees: 20
Average age: 27
SocialCee was founded in 2012, but our social media network knowledge and experience of social media communities dates back to the late 90's. The company has grown from a "kitchen desk" start-up to over 20 employees delivering solutions to customers across Europe.
At SocialCee we are passionate about world class technology combined with great customer service.
Our goal is to strengthen the relationship between companies and customers. We do this by enabling companies to engage and connect with their customers across social media platforms - in one enterprise software. SocialCee is a cloud based social media management and marketing software. The software enables businesses to integrate social media into critical business processes such as customer service, marketing, analytics and CRM.


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Congratulations to Jin and Richard for making it into the next round. Bernard put up more fight than anyone else so far, but it couldn't even come close to making it a tight one.
Jin: 94% (selected on 98.4% of all brackets)
Karl: 6% (selected on 1.5% of all brackets)
Richard: 83% (selected on 97.1% of all brackets)
Bernard: 17% (selected on 2.8% of all brackets)
The brackets have been updated. Are you one of the 1141 still in the running for the perfect bracket? I know I am. Perhaps things haven't been close enough with the matchups yet for your liking? Do you crave a bracket-busting throw-down?
I wouldn't say today gives us our first neck and neck bout, but it will certainly go a long way in affecting the chase for the perfect bracket. Our first matchup sees a sister taking on a wife. Will Rose fair better than her husband, or will Shannon be the end of her? Our second matchup is a battle between two dead Others. Will the good (Alex) conquer the bad (Bea)? Your votes will do the talking (and you can also do some talking in the comment section)!
Shannon Rutherford
Before the crash of Oceanic Flight 815, Shannon was the only daughter of a wealthy single father. Her dad married Sabrina Carlyle when she was eight years old, giving her a step-brother named Boone. When her father died, Sabrina cut her off and she spent a few years conning her gullible step-brother into giving her money. On the Island Shannon struggled to find a purpose and eventually helped Sayid decipher some of Rousseau's maps. They formed a relationship, which ended suddenly when Shannon was accidentally shot and killed by Ana-Lucia.
Rose Henderson
After surviving the crash of Oceanic Flight 815, Rose spent a good deal of time to herself. She was confident that her husband had survived the crash even though he had been in the tail section at the time. Before the crash, Rose had married Bernard only months after meeting him. She was diagnosed with terminal cancer but it seemed to have disappeared after crashing onto the Island. Because of this, Rose has been hesitant of any rescue attempt as she fears the cancer might return if she leaves. She was last seen at the beach camp before the Island disappeared.
Bea Klugh
A very mysterious person, Bea (or Ms. Klugh) was encountered by Michael after he was captured by the Others. She supervised a short meeting between Michael and his son Walt and seemed to instill fear in the boy. She was later seen at the Flame station, where she was captured by Sayid and Kate. However, before they could extract any information from her, she ordered Mikhail to shoot and kill her on the spot, which he did.
Alex Rousseau/Linus
Actually the daughter of Danielle Rousseau, Alex was taken from her mother by the Others shortly after her birth. She was raised to believe she was Benjamin Linus' daughter and grew up in the Others' community. A relationship developed between her and a young Other named Karl. Her adoptive father tried to prevent them from seeing each other but failed. At one time or another, Alex helped rescue Claire, Kate and Sawyer from the Others and eventually joined the Losties. She followed Locke to the Barracks and was taken captive by Keamy's team while she, Karl and Rousseau were hiking to the Temple. She was executed by Keamy during a raid on the Barracks.


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What is Botox®?
Botox® is a muscle relaxing agent, derived from Botulinum, which reduces wrinkles and fine lines by temporarily relaxing the muscle. The most common area of treatment is frown lines between the eyebrows, horizontal forehead lines, and crow's feet.It gives a non–surgical brow lift producing a relaxed and rejuvenated appearance. It may also be used to treat excessive underarm sweating.
Crow's Feet before and after treatment with Botox*
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Will there be any downtime?
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How long do Botox, Dysport and Xeomin treatments last?
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What are the alternative treatments?
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What are the limitations of Botox/Dysport/Xeomin?
Botox/Dysport/Xeomin is not a permanent answer to reducing wrinkles. Also, results vary and occasional problems with asymmetry may occur.
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Instructions before treatment:
Instructions after treatment:
*Results may vary.
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Response to 8 Hilarious Reasons Why "Amish Mafia" Is Fake:
I think it would have worked better as a complete fictional drama series with proper actors, more of a risk to any channel putting up the cash but then we`d all know where we stand, knowing it was fiction from the start. Although not the best series from Discovery this year, I still find it compulsive viewing, despite the fact it`s complete bollocks! It`s so out there as an idea, it seems the kind of thing Seth Macfarlane would have made as his next movie after Ted, lampooning the Italian mafia and the Amish at the same time! Bet he`s cursing he didn`t think of that one first!


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She cannot harm you or your siblings any more, says judge
SHE beat her children with wooden branches, hammers, frying pans, whips, lumps of coal, glass bottles, cups, blocks, and horse straps.
She regularly gave them black eyes from punching them.
She 'skinned' her daughters' hair so they wouldn't leave home.
One daughter was tied to a tree in the middle of winter and left "until she was nearly dead" because she had not washed clothes. When she finally untied her girl, the mother simply laughed. For those listening in the courtroom yesterday, the horror of what her eight children endured at the hands of their mother was almost too much to bear.
Living in caravans, the family moved regularly and set up camp in isolated, rural locations across the country.
They had three caravans -- but only the mother was allowed inside the caravan storing her coveted possessions.
From the day they were born, the children had no running water, sanitary facilities or electricity. The mother controlled all financial affairs to the detriment of her children. Any money the children got, she took from them and lodged in a post office account. She even took their Holy Communion money and spent it on cigarettes and alcohol.
The heinous offences were committed in the caravans and others at quiet wooded areas.
Some of the children went to secondary school, but others were denied an education and kept at home to work or beg for her.
During the few days one daughter went to school, she said she could not concentrate because she was thinking of the bad things that awaited her at home.
The children were locked in their caravan and given wet sheets to sleep on. They regularly had nothing to eat, or just a piece of dry bread.
When two children ran away from home, the mother blamed a son and daughter and gave them "an awful beating".
On other occasions, the children were beaten after begging their mother to stop assaulting their siblings.
When her six-year-old daughter was bleeding from her genitals, the mother refused to bring her to hospital. She bled for a week-and-a-half with a sister attempting to care for her from a press full of bloody nappies. Over time, the mother's alcohol addiction grew to the point where she consumed up to two bottles of vodka a day.
Six of the children are now in care. A social worker reported that when taken from the mother, the two youngest daughters had severe head lice infestation, throat and ear infections, overate when placed into foster care, and didn't know what underwear was for.
Addressing one daughter yesterday, Judge Raymond Groarke said: "Your mother cannot harm you and your siblings again."
Irish Independent


text: A lot of people still haven't even heard Paul's name let alone seen him skate, but all that's changing very quickly. Paul is making the kind of waves on his skateboard that just can't be ignored. Being from British Columbia makes him a very well-rounded skater like many who have emerged from that region before him. Some people develop a certain area of expertise on a skateboard; they become known for one thing or skill above others and it pigeon-holes them. Paul won't have that problem, as you can see on these pages. The tides are changing in the skateboard arena, and Paul Machnau is definitely going to be one of the major players. – Atiba Jefferson


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Fig. 4.1
The fear network in PTSD: sensory (rectangles), emotional (circles), cognitive (thought bubbles), and interoceptive (triangles) elements of the network are highly interconnected, as opposed to the autobiographical context information (rectangles below) which is stored separately (From Wilker and Kolassa (2013), reprinted with permission)
Evidence not only from cognitive psychology but also from neuroscience confirms distinct neural bases to the abstract, flexible, contextualized representations (cold memory) and to the inflexible, sensory-bound representations (Brewin et al. 2010; Kolassa and Elbert 2007). The latter, part of the hot memory system, is thought to be supported primarily by areas of the brain directly involved in perception (e.g., representational cortex, amygdala, insula) rather than in higher-order cognitive control. By contrast, cold memories require the involvement of the hippocampus and surrounding medial temporal lobe structures (Brewin et al. 1996, 2010). For emotional experiences within the normal range, hot and cold information are well integrated and stored together in autobiographical memory. Yet, if PTSD develops after trauma exposure, these two forms of memory become dissociated for two reasons: first, the extreme state of emotional arousal during a traumatic event, accompanied by the release of stress hormones, affects hippocampal functioning, which could explain the reduced consolidation of declarative memories in PTSD (Elzinga and Bremner 2002). Second, the experience of several traumatic experiences, which generally precedes the onset of PTSD, leads to the activation of the same fear memory structure, since different traumatic experiences share common elements (e.g., fear, screams, and blood). Hence, the hot memories for several traumatic experiences merge in one fear network and strengthen the associative interconnections of its elements. This makes it increasingly difficult to disentangle the different traumatic experiences and, particularly, to recall the adequate corresponding context information. Following principles of associative learning, an interconnected fear network thus encompasses sensory, cognitive, physiological, and emotional experiences and includes the action disposition related to the experience (sensory representation, hot memory) but is detached from the autobiographical context information. Furthermore, the strength of the interconnections of the fear network, as well as the number of elements integrated in the network, increases with accumulating trauma exposure, which explains the aforementioned dose-response effect of traumatic load. Environmental stimuli (e.g., a smell or noise) and internal cues (e.g., a thought), usually in combination, can later activate this network at any given time. The ignition of only a few elements in the network is sufficient for activating the whole structure and leads to strong involuntary memories (intrusive symptoms). This may express itself as a flashback, a perception that one is back in the traumatic situation with its sounds of the harsh voice, smells of blood, feelings of fear, and thoughts of dying (cf. Fig. 4.1). Since the activation of the fear network serves as a frightening and painful recollection, many people suffering from trauma-related experiences learn to avoid cues that act as reminders of the traumatic event. They try to avoid thinking about any part represented in the fear/trauma network, not to talk about it, and to stay away from people and places that remind them of the frightening event.
The fear network model corresponds well with results of structural and functional alterations in the brain of trauma survivors with PTSD (see Sect. 4.4 in this chapter) and provides not only a neurobiological explanation of the development of PTSD symptoms in the aftermath of traumatic stress but also a rationale for trauma-focused therapy approaches (Kolassa and Elbert 2007). The reactivation of consolidated memories turns them into a labile state in which modification is possible (Nadel et al. 2012). Hence, the activation of the fear network during treatment allows the modification of the present memory structure through habituation and extinction learning (Ehlers et al. 2010). One example of such an exposure-based treatment is Narrative Exposure Therapy (NET; Schauer et al. 2011 see also Chap. 12 of this book) – a short-term treatment for traumatic stress disorders. By connecting the "hot" sensory, emotional, cognitive, and interoceptive memories of the trauma to the "cold" autobiographical memories, an activation of the fear network disconnected from context can be prevented and the client can achieve control over the distressing memories. The therapist further supports the client to work through the experienced traumatic experiences in a chronological order, which helps to disentangle the traumatic events which merge in the fear network. The effectiveness of NET supports the concept of a fear network in PTSD (see Robjant and Fazel 2010 for a review on evidence for the effectiveness of NET).
4.2 Genetic Factors in the Etiology, Symptomatology, and Treatment of PTSD
As summarized above, traumatic load increases the risk to develop PTSD in a dose-dependent manner. Yet, individual risk factors are known to interact with traumatic load and influence the likelihood of subsequent PTSD development. From a biological perspective, it is hence crucial to look at genetic and epigenetic risk factors for PTSD.
4.2.1 Heritability of PTSD
Family studies examining biological relatives of patients diagnosed with PTSD first indicated genetic risk factors in disorder etiology. For example, children of PTSD patients from different contexts (Holocaust survivors, Cambodian refugees) were found to be at greater risk for PTSD following trauma exposure (Sack et al. 1995; Yehuda et al. 2001). Given that families share genetic and environmental influences (e.g., observational learning and parental distress), twin studies are needed to examine the heritability of PTSD more closely. Comparing PTSD in identical or monozygotic (MZ) twin pairs with those in fraternal or dizygotic (DZ) twin pairs results in heritability estimates of PTSD around 30–40 % (Stein et al. 2002; True et al. 1993), a figure which corresponds with estimates for anxiety disorders (Hettema et al. 2003). However, caution is needed, as identical twins may share a more similar exposure to stressful experiences in comparison to fraternal twins.
Whereas twin studies are useful to estimate the heritability of a disorder or trait, association studies are needed to identify which genes and, hence, physiological mechanisms are involved in the etiology of a certain disorder. Candidate gene association studies compare the genotype frequencies of polymorphic regions of certain candidate genes between affected individuals and healthy controls. Polymorphic regions of the genome are defined as regions that vary naturally between individuals. The most commonly studied polymorphisms are single nucleotide polymorphisms (SNPs; variation in a single base pair) and variable number of tandem repeat polymorphisms (VNTRs; the number of repeats and, hence, the length of a repetitive region of the genome differ). As a consequence, both polymorphisms can lead to functional differences in the gene-expression product.
Since PTSD requires exposure to an environmental stressor to manifest, the standard case-control design is not adequate for PTSD research, since controls might also carry genetic risk factors which never had an impact because the individual was not sufficiently exposed to traumatic stressors. Therefore, to understand genetic susceptibility of PTSD, it is crucial to carefully assess traumatic load and include it in the subsequent genetic analyses (Cornelis et al. 2010; Wilker and Kolassa 2013).
4.2.2 Genetics of the Fear Network
According to the fear network model detailed above (Elbert and Schauer 2002; Kolassa and Elbert 2007), strongly interconnected, highly accessible emotional-sensory fear memories, which are detached from the corresponding autobiographical context information, lead to intrusive PTSD symptoms (Wilker and Kolassa 2013).
Accordingly, fear memory formation, and fear conditioning in particular, has been widely used as a model for PTSD development. Fear conditioning is a prominent paradigm in PTSD research, since it can be easily studied in animals and provides a sound explanation on how previously neutral stimuli (e.g., a policeman) can become triggers of fear due to a traumatic experience. The hippocampus, the medial prefrontal cortex (mPFC), and the amygdala (together termed limbic-frontal neurocircuitry of fear) were identified as the main areas involved in the acquisition and regulation of conditioned fear in animal studies. The interplay of these areas during (traumatic) stress is influenced by the neuromodulatory actions of neurotransmitters, such as serotonin, dopamine, and norepinephrine, as well as hormones, such as glucocorticoids (for reviews see, e.g., Ressler and Nemeroff 2000; Rodrigues et al. 2009; Shin and Liberzon 2009). Therefore, these systems have been targeted by candidate gene association studies on PTSD.
Whereas studies only comparing the prevalence of genetic risk alleles in PTSD patients and controls have yielded conflicting results, research which accounts for the aforementioned building block effect and, hence, investigates gene × environment interactions has brought converging evidence for several genetic risk factors which will be summarized in the following.
18.104.22.168 Modulators of the Serotonergic System
The neurotransmitter serotonin is known to influence emotional learning and memory through its inhibitory action on the amygdala (cf. Meneses and Liy-Salmeron 2012; Ressler and Nemeroff 2000). The serotonin transporter is responsible for the active clearance of serotonin from the synaptic cleft. Among candidate genes encoding proteins involved in the serotonergic system, there is convergent evidence indicating an influence of the serotonin transporter gene on the risk to develop PTSD subsequent to traumatic stress. A length polymorphism within the promoter region of the serotonin transporter gene (termed serotonin transporter gene-linked polymorphic region; 5-HTTLPR) influences its activity: in contrast to the long (l) allele, the short (s) allele is associated with lower gene transcription and, hence, lower serotonin transporter activity, higher amygdala reactivity to emotional stimulation, and enhanced fear conditioning (Greenberg et al. 1999; Heils et al. 1996; Lonsdorf et al. 2009; Munafò et al. 2008). Studies investigating gene × environment interactions consistently show that the short variant enhances PTSD susceptibility subsequent to traumatic stress (Kilpatrick et al. 2007; Kolassa et al. 2010a; Mercer 2012; Pietrzak et al. 2013; Xie et al. 2009, 2012). To give an example, in a sample of Rwandan genocide survivors, carriers of the long variant of the serotonin transporter polymorphism showed the typical building block effect: the more traumatic events experienced, the higher the prevalence of PTSD. Yet, this cumulative effect was not seen in individuals carrying two copies of the short alleles, who already developed PTSD at relatively low traumatic load (Kolassa et al. 2010a; cf. Fig. 4.2).
Fig. 4.2
Fitted values of probability for lifetime PTSD plotted against the number of traumatic event types for different genotypes (From Kolassa et al. (2010a), reprinted with permission)
Interestingly, the short allele was also associated with higher risk of PTSD symptom relapse 6 months after the completion of an 8-week trauma-focused cognitive behavior therapy (Bryant et al. 2010), suggesting more persistent fear memories in carriers of this risk genotype. Furthermore, PTSD patients who were homozygous for the long allele showed higher responsiveness to a pharmacological PTSD treatment with sertraline as well as a lower dropout rate (Mushtaq et al. 2012). Whereas there are only few studies investigating the influence of genetic polymorphisms on PTSD treatment success, this first evidence might indicate the need of personalized treatments depending on individual biological risk factors.
184.108.40.206 Modulators of the Dopaminergic System
Dopamine is another neuromodulator of the neurocircuitry of fear. More precisely, dopaminergic influx in the amygdala is important for the consolidation of fear memories (Guarraci et al. 2000). Dopaminergic activity is modulated by the enzyme catechol-O-methyltransferase (COMT), which degrades and thereby deactivates dopamine and other catecholamines. A SNP in the COMT gene results in the integration of the amino acid methionine (Met) instead of valine (Val) in the resulting protein (COMT Val158Met polymorphism). On the functional level, the Met allele is associated with lower COMT enzyme activity and, therefore, higher extracellular dopamine levels (Lachman et al. 1996), as well as impaired fear extinction learning (Lonsdorf et al. 2009). Similarly, the Met allele has been found to interact with traumatic load to predict higher risk for the development of PTSD (Boscarino et al. 2011; Kolassa et al. 2010c). Furthermore, there is initial evidence that this polymorphism might influence therapeutic treatment success. To date, only one study has investigated the influence of COMT genotype on psychotherapeutic outcome in a sample of panic disorder patients and found that Met/Met carriers benefited less from the exposure-based elements of the treatment (Lonsdorf et al. 2010). Since effective PTSD treatments also require exposure to the traumatic experiences, it would be interesting to investigate whether these findings translate to PTSD.
18.104.22.168 Modulators of the Biological Stress Responses
During a stressful or traumatic experience, the body's alarm response is initiated by two major stress axes, the hypothalamus-pituitary-adrenal (HPA) axis and the locus coeruleus noradrenergic (LCNA) system. Their joint activity prepares the body for survival, e.g., by mobilizing glucose, increasing the heart rate and blood pressure, and enhancing muscle tension.
The HPA axis activation consists of three steps: initially, corticotropin-releasing hormone is released from the hypothalamus. This stimulates the pituitary gland to secrete adrenocorticotropic hormone, which leads to the release of cortisol from the adrenal glands. Whereas this stress response is initially adaptive, a prolonged HPA axis activity can lead to adverse health consequences. In order to avoid chronic HPA axis activation, the binding of cortisol to glucocorticoid receptors exerts negative feedback on the release of further corticotropin-releasing hormone and adrenocorticotropic hormone from the hypothalamus and pituitary, respectively. Elevated cortisol levels have been further found to increase the memorization of emotional experiences, rendering the glucocorticoid system an interesting target for candidate gene association studies on PTSD (see, e.g., Wolf 2009 for a review). Yet, studies investigating glucocorticoid receptor polymorphisms have yielded inconsistent results (Bachmann et al. 2005; Hauer et al. 2011). Another interesting candidate in the glucocorticoid system is the gene encoding co-chaperone FK506-binding protein 51 (FKBP5), which regulates cortisol-binding affinity of the glucocorticoid receptor. More precisely, when FKBP5 binds to co-chaperone FK506, the resulting receptor complex decreases the binding capacity for cortisol (Binder 2009), resulting in reduced negative feedback and, hence, a prolonged stress reaction. So far, research consistently points towards an interaction of FKBP5 risk alleles and adult or childhood trauma exposure in the risk to develop PTSD (Binder et al. 2008; Boscarino et al. 2011, 2012; Xie et al. 2010).
Stress or emotional arousal leads to the release of noradrenaline from the basolateral amygdala, and this noradrenergic neurotransmission is required to form memories of emotional experiences (e.g., McGaugh and Roozendaal 2002). PTSD is associated with both central and peripheral noradrenergic hyperactivity (Heim and Nemeroff 2009), yet few studies investigated genes involved in the noradrenergic system. One interesting exception is the work of de Quervain and coworkers (2007), who investigated a deletion variant in the gene ADRA2B, coding the alpha-2B-adrenergic receptor, which was associated with enhanced memory for emotionally arousing material in healthy volunteers and more pronounced intrusive memories in survivors of the Rwandan genocide (de Quervain et al. 2007).
In sum, reliable genetic associations were found with genes involved in the development of pathological memories. Understanding genetic risk factors relevant to the formation of intense fear memories is especially important, since those biological systems present a promising target for modifications through future treatment opportunities, especially on a pharmacological level.
Yet, despite increasing efforts and technological advances, only a small proportion of the estimated PTSD heritability can be explained by the identified genetic risk factors. Explanations for this "missing heritability" (Manolio et al. 2009) include the presence of complex multigene interactions and interactions between the individual environmental exposure with the genetic makeup of a person. Furthermore, research in the last decades has elucidated that environmental exposure can shape gene expression through epigenetic modification (Zhang and Meaney 2010). The next section will hence illuminate epigenetic mechanisms, which are essential to obtain a full understanding of the interaction of nature and nurture in PTSD etiology.
4.3 Epigenetic Alterations Associated with PTSD
The term epigenetics originates from the Greek syllable epi, meaning upon, and genetics. The epigenome can be viewed as a "second layer of information" (Zhang and Meaney 2010, p. 447) which consists of chemical modifications altering the accessibility of the DNA, without changing the sequence of nucleotides. More precisely, gene expression depends upon the binding of transcription factors to the promoter region of a gene, and different epigenetic mechanisms dynamically allow or prevent transcription factor binding. These mechanisms are crucial to cell differentiation: since the genome of mostly all cells in a given human individual is the same, the epigenetic profile allows the specialization regarding the cellular function (e.g., heart cell vs. neuron) by determining which genetic sequences are expressed as proteins. Furthermore, and of particular relevance in the context of PTSD, epigenetic alterations allow for the dynamic adaption of gene expression to challenging environmental demands (Zhang and Meaney 2010). In the last years, evidence suggesting that traumatic stress can influence the individual epigenetic profile has accumulated (Malan-Müller et al. 2013). At first, it was supposed that particularly early developmental adversity leads to alteration in the epigenome, which can be associated with higher stress vulnerability later in life. Thereafter, however, it was acknowledged that epigenetic modifications occur during the entire lifespan and are crucial to learning and memory (Zhang and Meaney 2010). Hence, on the one hand, early developmental stress can lead to stable epigenetic alterations which constitute a risk factor for later PTSD development. On the other hand, adult traumatic stress might also lead to epigenetic modifications which could in turn perpetuate the psychological symptoms and biological alterations associated with PTSD.
The three epigenetic mechanisms which may lead to an alteration of the transcriptional accessibility of genes without changing their structure are RNA-associated silencing, histone modification, and most prominently DNA methylation (Egger et al. 2004). The modifications can enhance or decrease gene expression and even "silence" the gene entirely (Sutherland and Costa 2003).
First evidence for the influence of early experiences on the epigenetic profile stems from animal studies which show that low versus high maternal care of rat mothers leads to differential DNA methylation in their offspring (Weaver et al. 2004). More precisely, low maternal care was associated with enhanced methylation of the glucocorticoid receptor gene (GCCR) promoter in the hippocampus and, hence, reduced GCCR expression. As indicated earlier, the GCCR is involved in negative regulatory feedback of the hypothalamic-pituitary-adrenal (HPA) axis. Increased GCCR promoter methylation can therefore reduce GCCR sensitivity, which might lead to a prolonged HPA activation under stress. Returning to the study by Weaver et al. (2004), these epigenetic changes, which may persist into adulthood, could be prevented by placing the rodents with rat mothers providing them with high maternal care – a finding that is of utmost importance for psychotherapy in the field of psychotrauma.
McGowan et al. (2009) showed comparable findings in humans: they found enhanced methylation in a neuron-specific glucocorticoid receptor gene (NR3C1, the human homolog of the site investigated in rats in the Weaver study) promoter in the hippocampi of suicide victims who had experienced childhood abuse, compared to suicide victims with no documented history of childhood abuse. The study implies a common effect of early stress experiences on the epigenetic regulation of hippocampal GCCR expression (McGowan et al. 2009). This was confirmed by a recent study (Mehta et al. 2013) comparing DNA methylation and gene expression between a sample of PTSD patients with childhood and adult trauma, a PTSD sample without childhood trauma, and a trauma-exposed control group without PTSD. The authors found distinct gene expression patterns in the two PTSD groups, indicating differential biological pathways involved in PTSD etiology depending on childhood trauma history. Furthermore, only in the childhood trauma group, differences in gene expression overall matched with epigenetic modifications of the corresponding gene loci, suggesting that childhood trauma leads to enduring epigenetic alterations which still influence gene expression in adulthood.
Likewise, Radtke et al. (2011) showed for the first time that prenatal stress – in particular intimate partner violence – experienced by mothers during pregnancy altered the methylation status of the GCCR of their offspring (assessed at age 10–19). Hence, this study provides a possible link between prenatal stress and psychopathology later in life (Radtke et al. 2011).
Indeed, recent studies provide initial evidence that epigenetic modifications influence the probability of PTSD development. For instance, Koenen and colleagues showed in a primarily African American sample from the Detroit Neighborhood Health Study that methylation level at the serotonin transporter promoter polymorphisms (5-HTTLPR) and traumatic load interacted to predict PTSD vulnerability (Koenen et al. 2011). Chang and colleagues investigated the dopamine transporter gene, another genetic locus previously found to be implicated in PTSD vulnerability (Drury et al. 2009; Segman et al. 2002; Valente et al. 2011; but see Bailey et al. 2010). They found the highest PTSD probability in carriers of the high-risk genotype, who also present with higher methylation levels at this locus (Chang et al. 2012). Moreover, it was recently suggested that the combination of an FKBP5 risk genotype and early adversity leads to demethylation at the FKBP5 locus, which may be associated with higher FKBP5 responsiveness and an augmented stress response later in life (Klengel et al. 2012). These studies provide first evidence that traumatic experiences, especially if they occur during early developmental windows, can shape the epigenetic profile, which in turn influences the vulnerability for PTSD in the case of subsequent trauma exposure. Furthermore, the work of Klengel and coworkers indicates that epigenetic alterations may be influenced by genotype. Consequently, we are confronted with a complex interaction of genetics, epigenetics, and early and late trauma exposure in the prediction of PTSD.
4.4 Structural and Functional Alterations in the Brain of Trauma Survivors with PTSD
Structural changes associated with PTSD such as hippocampal atrophy could be the cause for functional impairments and dysfunctions associated with PTSD (Sherin and Nemeroff 2011) but were also discussed as risk factors (Gilbertson et al. 2002).
Using brain-imaging methods, PTSD has been implicated with structural changes in the medial prefrontal cortex (mPFC), the amygdala, and the hippocampus (see Liberzon and Sripada 2008 for a review). The mPFC performs inhibitory control over stress responses through its connection to the amygdala, and it plays a major role in fear extinction (Heim and Nemeroff 2009). According to the neurocircuitry model of PTSD, regions of the ventral mPFC, which are supposed to inhibit the amygdala, are dysfunctional in patients suffering from the disorder. At the same time as the amygdala responses are amplified, the hippocampus shows deficits in explicit learning and memory and, therefore, fails to identify safe environments (Rauch et al. 2006). The hippocampus (Fig. 4.3) is especially important in the development of PTSD; it is crucial for controlling stress responses as well as declarative memory, and it plays a major role in contextual aspects of fear conditioning (Heim and Nemeroff 2009). Since this area of the brain is known for its high plasticity, studies investigating structural changes in the brain due to PTSD have mainly focused on volume changes in the hippocampus (Hughes and Shin 2011). Animal studies show that pathological stress can lead to hippocampal size reduction, possibly caused by adverse effects of stress hormones (Sapolsky et al. 1990). Several meta-analyses describe smaller hippocampal volumes in trauma-exposed individuals with and without PTSD, when compared to a non-exposed control group (Smith 2005; Woon et al. 2010), while others find hippocampal volume reduction only in PTSD patients but not in trauma-exposed and non-exposed control groups (Karl et al. 2006; Kitayama et al. 2005).
Fig. 4.3
Morphological alterations of the hippocampus have been repeatedly found in PTSD and might represent a risk factor or a consequence of the disorder
Gilbertson and colleagues (2002) conducted a study with twins; they compared war veterans with combat exposure to their twins without combat exposure. In accordance with previous studies, they also found smaller hippocampi in PTSD patients. However, the co-twins of the PTSD patients who neither suffered from PTSD nor had been exposed to combat also had smaller hippocampi compared to the non-PTSD control group (Gilbertson et al. 2002). This suggests smaller hippocampal volume to be a risk factor for PTSD rather than a consequence of the disorder. In a further study, configural processing performance was found to be significantly lower in PTSD patients in comparison to trauma-exposed controls. Nevertheless, the co-twins of the PTSD patients showed the same impairments which were related to hippocampal volume, even though they did not suffer from PTSD, nor were they trauma-exposed as adults (Gilbertson et al. 2002). However, a recent study of Teicher et al. (2012), which presents evidence that childhood adversity massively affects hippocampal development, provides an alternative explanation for the results of the Gilbertson work group. It is possible that those twins exposed to adversity during vulnerable childhood periods may have both a reduced hippocampal volume and a greater risk for developing PTSD when exposed to combat. Possibly such altered development of hippocampal organization may reduce contextualizing representations of stressful events and generalize fear. While this brain organization may be adaptive in dangerous environments, it also includes the risk of extending the fear network and eventually the maladaptive formation of PTSD.
Finally, another study found reduced hippocampal volume in current PTSD patients compared to a control group with remitted PTSD. Again, two alternative explanations could account for this finding: on the one hand, lower hippocampus volume could be a risk factor for a chronic pathology of PTSD. On the other hand, smaller hippocampus volume could be a consequence of PTSD, which might be reversible if the disorder remits (Apfel et al. 2011).
To conclude, the current state of research does not clearly support the notion that reduced hippocampus volume is a consequence of traumatic stress or a (genetic) risk factor for PTSD onset. Yet, an association of PTSD with reduced hippocampal volume is evident and corresponds well with the assumption of unreliable autobiographical context information of the fear network model.
Since the amygdala plays a central role in the neurocircuitry of fear in general, and the acquisition and expression of conditioned fear reactions in particular, several studies looked at structural alterations of the amygdala in survivors suffering from PTSD. Yet, in contrast to research on hippocampus volume, results are far from consistent. For instance, a meta-analysis from 2009 which summarized nine studies found no differences in left and right amygdala volume if PTSD patients were compared to trauma-exposed or unexposed control groups (Woon and Hedges 2009). More recent studies continue to provide inconsistent findings. Kuo and colleagues (2012) found enhanced total amygdala volumes in combat veterans with PTSD compared to trauma-exposed veterans without PTSD. Yet, another study also investigating trauma-exposed military veterans found reduced left and right amygdala volume in PTSD (Morey et al. 2012).
Finally, PTSD-associated structural alterations of the PFC, which plays a central role in fear inhibition and extinction learning through its inhibitory influence on the amygdala, have been investigated. A recent meta-analysis summarized the results of nine studies using voxel-based morphometry to assess gray matter volume in PTSD patients opposed to trauma-exposed controls and found significantly reduced volumes in several regions implicated in the neurocircuitry of fear, including the left hippocampus and the ventromedial PFC (Kühn and Gallinat 2013).
In addition to the identified structural alterations in the neurocircuitry of fear, it is also of interest to understand if the functioning or the interplay of these structures is altered in PTSD patients. A consistent body of research indicates that amygdala reactions to threatening cues are accelerated in PTSD. The common design to investigate amygdala reactivity is to compare brain activity while presenting neutral versus emotional stimuli. For instance, Brohawn and coworkers (2010) found significantly elevated amygdala reactivity in response to negative pictures in PTSD patients compared to trauma-exposed controls. These results were confirmed in numerous studies, revealing higher amygdala activity in response to fearful or aversive stimuli in PTSD patients versus controls (see Hayes et al. 2012 for a recent meta-analysis), as well as a positive correlation between current PTSD symptom severity and amygdala reactivity to these stimuli (Armony et al. 2005; Dickie et al. 2008, 2011). In addition, a recent study found enhanced spontaneous amygdala activity in PTSD, indicating that an increase in amygdala activity in PTSD is not only present during specific experimental provocations but can be a general condition in PTSD (Yan et al. 2013). Heightened amygdala activity is associated with decreased mPFC activity in response to aversive stimuli (Hayes et al. 2012). This is supplemented by recent evidence indicating that trauma survivors with PTSD show reduced functional connectivity between the amygdala and the mPFC in response to fearful stimuli, a finding that can further explain the failure of the mPFC to inhibit exaggerated amygdala responses in PTSD (Stevens et al. 2013).
Somewhat in contrast to the general finding of prefrontal hypoactivity in PTSD, Adenauer and colleagues found enhanced early activation in the right prefrontal cortex in response to aversive pictures in PTSD patients, compared to trauma-exposed individuals not suffering from PTSD and unexposed control subjects (Adenauer et al. 2010). Such early activity might be missed in functional magnetic resonance imaging studies, which have a lower time resolution than the magnetoencephalography (MEG) paradigm implemented in the Adenauer study. This early prefrontal activity might represent an acquired hypersensitivity to threatening stimuli in a traumatized brain, which constitutes one form of expression of a strong fear network that is prepared to rapidly detect danger (Rockstroh and Elbert 2010). This early adaptive activation is most likely followed by subsequent deactivation of prefrontal regions, a vigilance-avoidance pattern that was also described for other anxiety disorders (Adenauer et al. 2010).
4.5 The Effects of Psychological Trauma on Physical Health: Identifying Potential Molecular Modulators
PTSD has been associated with poor self-reported health and increased healthcare utilization (Schnurr and Jankowski 1999) but also unfavorable lifestyle factors such as physical inactivity and smoking (Zen et al. 2012). Psychological stress, particularly if it takes extreme (traumatic) forms, has been shown to enhance the risk for cardiovascular, cerebrovascular, respiratory, gastrointestinal, musculoskeletal, inflammatory, and autoimmune diseases, as well as other age-related diseases including even cancer (Boscarino 2004; Felitti et al. 1998; Fuller-Thomson and Brennenstuhl 2009; Glaesmer et al. 2011; Schnurr and Jankowski 1999). For more details, see Chap. 5.
Although traumatic experiences and PTSD have often been related to adverse health outcomes, the precise molecular mechanisms underlying this relationship warrant further investigation. The ongoing stress an individual is exposed to through adverse environments (traumatic stressors) seems to cause the immune system to age prematurely and to alter various molecular pathways. Sommershof et al. (2009) showed a relative reduction in naïve cytotoxic and regulatory T cells in the lymphocytes of PTSD patients as well as a relative increase in memory T cells due to more past infections and a higher wear and tear of the immune system. The reduction in naïve cytotoxic T cells might lead to a compromised immune response, which could then contribute to the enhanced susceptibility for infections. A similar effect is observed in elderly people, where the natural reduction of naïve T lymphocytes leads to a greater risk for diseases associated with aging (Shen et al. 1999). In addition, the reduction of regulatory T cells might put PTSD patients at risk for inflammatory and autoimmune diseases. Indeed, there is a high prevalence of autoimmune and inflammatory diseases in PTSD patients (Boscarino 2004). More interestingly, we observed in this study (Sommershof et al. 2009) and in an extension study (Morath et al. 2014a) that naïve cytotoxic T cells and regulatory T cells were also reduced in trauma-exposed individuals without a diagnosis of PTSD; this group took an intermediate position between PTSD patients and controls. As traumatized individuals with PTSD usually experienced more traumatic events than traumatized individuals without PTSD, this suggests a cumulative effect of traumatic stress on T-cell distribution independent of the diagnosis of PTSD (Sommershof et al. 2009).


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On the Menu: Beauty or Brains
Many, many years ago, when I was in high school, I had the opportunity of going to the motherland of Korea to help teach in a 2-week English language immersion program. I had the youngest class, seven adorable little 5- and 6-year-olds who barely knew their ABCs. Since they were learning the very basics it… Read More »


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CapTel 2400i Telephone calls can be challenging for people with hearing loss. The new CapTel makes it easy to enjoy phone conversations, confident you'll catch every word. The CapTel 2400i shows word-for-word captions during your calls and features a large touch-screen display. The 24-hour-a-day captioning service is offered at no cost to callers. However, users are responsible for their long distance charges. Most captioned phones require high-speed internet, which is not covered by the program. For more CapTel information, visit:CapTel 2400i
Serene Innovations® HD-50JV The Serene Innovations® HD-50JV is a jumbo key corded amplified phone with more than just the usual features. It is equipped with VoiceAmatic voice-activated answering that allows you to answer incoming calls by simply saying "Hello." No need to rush to pick up the phone call; its high-performance speakerphone will do all the work.
Clarity XLC3.4 Cordless phone with Caller ID amplifies incoming sound up to 50+dB and outgoing speech up to 15dB, making it an ideal solution for severe hearing loss and low speech. Four tone settings, large font and a high contrast screen also assist individuals with low vision and limited mobility.Clarity XLC3.4
Clarity AltoPlus This telephone lets individuals with hearing loss stay connected with friends and family. The Alto phone series is the first on the market with TIA-4953 certified for mild, moderate and severe hearing loss. The Clarity AltoPlus amplifies caller's voices up to 53dB, and features talking Caller ID and a talking keypad for mild to severe hearing loss.Clarity AltoPlus
Clarity Fortissimo This is a remote-control, hands-free speakerphone with Bluetooth connectivity and a color touch screen. Like nothing before it, the Fortissimo combines amplification with easy-to-use, innovative features to help people with hearing loss, low-vision and limited mobility.Clarity Fortissimo
Uniphone 1140 Voice Carry Over TTY/HCO/Phone A combination TTY, telephone and amplified handset that has all the features of the Uniphone 1000 (Voice Carry Over, Auto ID, Turbo Code, 2 line LCD display, Call Progress, loudness control for handset) plus more advanced features.Uniphone 1140 Voice Carry Over TTY/HCO/Phone
ClearSounds CLA7v2 Amplified Powered Neckloop The CLA7v2 is an amplified powered neckloop that reduces or eliminates interference between cellular and t-coil hearing aids/cochlear processors. It provides hands-free calls with great sound quality and up to 30dB amplification for corded, cordless and cellular phones. Now users do not need to have multiple headsets or switch headsets for different activities.ClearSounds CLA7v2 Amplified Powered Neckloop
RC100/RC200 Headset with Microphone Ensure privacy for personal conversations or confidential calls with this headset accessory for the Dialogue RC100/RC200. This can be used with the Uniphone TTY in HCO or VCO mode to avoid having to pick up and put down the hand set to type during calls.RC100/RC200 Headset with Microphone


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The South Bay's last roller skating rink may be closing, but that isn't stopping patrons from rocking and rolling until the doors shut at the end of May.
The owners of San Jose Skate are planning an official farewell May 31, said representative Christi Pitt, and parties are scheduled in the weeks leading up to the closing date, including a "So Long to Skate" concert series scheduled for 7 p.m. May 23 and 24.
Andrew Kutsenda, former general manager, helped to organize the concert events.
"I wanted to make sure the place went out with a proper farewell," he said. "It's a shame to see a place that contributed so much culture to San Jose finally closing its doors. Without it, San Jose feels just a little more sterile."
Don Imwalle, who purchased the property this year, said the "waning popularity of roller skating" has made business tough for the rink.
"The operator of San Jose Skate has worked very hard to keep the business going for years," Imwalle said.
The closure will also leave the Silicon Valley Roller Girls–the local roller derby league–without a rink, with their last bout on closing night.
"We're going to be homeless and could use support from the community," said Stephanie Drews, vice president of the league that has made San Jose Skate its home for seven years.
Drews said the league is trying to raise $20,000 to find a new space. Rollin' Ice, located at Silver Creek Sportsplex, is designed for roller hockey, she said.
San Jose Skate has gone through many name changes since its opening–Aloha, Roxy's and Golden State Roller Palace–but has remained a mainstay for many events, skating lessons and birthdays.
Resident Deanna Alt said she had memories that couldn't have been made at other establishments.
"[My] first time on skates, first major fall, first family outing," Alt said. "I will cherish my memories and be saddened by its departure."
Imwalle said he wants to fix up the aging structure and secure a use that complies with current zoning, but has not yet identified a tenant.


text:
Build Guide by
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Taric Build
Ability Sequence
Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Taric is my favourite champ and I can never get bored of playing him as he is very fun, good at trolling with his stun, hard to kill if you are good and alround a pain in the arse to play against if your laning partner is good
Pros and Cons of this build
Pros -
-You should never lose a game as you should be fed, I suggest getting a partner to do ranked with and just let him farm creeps and gank your openents rly hard with the early game stun.
-by level 3-5 you should be totally fed because you have ganked your openents so hard and by this point you still have not gone to base.
-Shatter hits so hard only game 3-5 aswell so try to use that to help your ganks
-Get a partner with Excaust and time your stun so that excaust is put on straight after so they rly cannot get away and you get first blood or w/e your doing end game
-Heals are crazy endgame
-Stun the main source of dmg on the others team so in team fights you can own harder
-Get a pink skin like me and get commented on how gay you look when rly you totally own them :)
-you need to be rly fed from the other team, if not then either your partner is bad or you need to practice, im usually get about 4assists and if your partner is smart he will let you het the killing blows so he can farm minions = equal gold.
-people in solo lane have fed the other team resulting in you being ganked some one from mid who has like 8kills at level 8 :<
-you cant rly do any dmg and some times you will find that your heals are useless because your team our bad
overall I enjoy Taric though and I got rly good scores :)
Okay from what I have seen Taric from Frozen Heart you should have enough armour to keep alive against an AD but you also have about get abit of Magic Resist
so before the item Spirit Visage I would suggest getting a
Banshees Vale
Get this Vs Karthus, Ashe,Lux and any other Champ that is pissing you off early game then you may aswell get this to block 1 of there spells.. It all depends on whos rly fed.
Force of Nature
To choose between these 2 is hard, but if your team are really squishey champs then I would suggest Frozen Heart and then to try to offtank, this also gives you more health Regen so you dont have to go back if your pushing Inhibs or Towers.
The reason I have chosen Spirit Visage is because your ulti becomes x20 op and makes you unable to be ganked or focused if you have it up with Spirit Visage
Laning partners
Find a friend who can play a AP or AD carry, I have tried it with my brother as
Taric / Yi - Effective all round specially with a Yi spamming Q and then getting full mana via clarity, we usually get first blood with this and works very well end game as you should have atleast 2-5kills by level level 5-6 so the game is won if you and yi our fed.
Taric / Brand - Gg for them, level 2 = double stun, get brand to use ignite and watch them cry in /all . but I would suggest not doing this cause Brand in mid is proberly more effective
Taric / Nocturn - Works okay, but I would suggest making nocturn jungle :P
Taric / Lee sin - by far my favourite comp, this is what I spam ranked with and it works like a charm. I stun, he uses that charge thing :P and its gg with Shatter and Excaust.
Taric / Xin - Xin is op atm meaning this is proberly the best laning with Taric atm, but you can easily be counted because xin is pretty week until level 3 and you want First blood remember :P
I could type some others but from personal opinion you want to work with an AD / AP carry that has high burst early game that will carry end game if fed.
Otherwise Taric is a great partner to lane with so if you havnt already try this out :)


text:
Pharma Society mourns death of Dr. H. P. Tipnis
Dr. Hemchandra P Tipnis – the man who ushered Pharmacy Profession in India on a new journey has just finished his own. You will continue to inspire us for long time."
Retired Principal of Bombay College of Pharmacy and Central Executive Council Member of Indian Pharmaceutical Association (IPA) passed away on May 23, 2016 after a massive cardiac arrest.
Dr Hemchandra P Tipnis had humble beginnings, but rose to become a top in the Pharma Field, completed his BSc (Tech) and MSc (Tech) from University Department of Chemical Technology in 1958. Further completed his M.S. and Doctorate from University of California School of Pharmacy at San Francisco and University of Nebraska, Omaha respectively
He has started his career with UDCT as a Reader, Further worked as a Principal of Bombay College of Pharmacy (1971-1995). During his career strived hard to make attain prime position of Bombay College of Pharmacy as well as strengthening the Pharma Industry Institute Interaction
He have Guided several M. Pharm, M. Sc and Ph. D Students. He have many National and International Publications and Books on his credit.
Book titles to his credit includes:
• Community Pharmacy (Dr. H. P. Tipnis),
• Hospital pharmacy (Dr. H. P. Tipnis & Dr. Amrita Bajaj),
• Clinical Pharmacy (Dr. H. P. Tipnis & Dr. Amrita Bajaj),
• Principles and Applications of Biopharmaceuticals and Pharmacokinetics (Dr. H. P. Tipnis & Dr. Amrita Bajaj),
• Inorganic Pharmaceutical Chemistry (Theory) (Dr. H. P. Tipnis & Dr. A. S. Dhake),
• Pharmaceutical Chemistry (Dr. H. P. Tipnis & Dr. A. S. Dhake).
His research work includes Bioavailability studies, QSAR, Natural Pest Control Agents
He was elected as President of Indian Pharmaceutical Congress (IPC), in 2007
He was Scientific Convener of IPCs in 1988, 1989,1990 and 1991
The various awards to his credit includes:
• Lunsford Richardson Award, USA
• M. L. Khurana Award
• Eminent Pharmacist Award
• Lifetime Achievement Award of APTI


text:
NWT Roxy L brown DARCYCIRCLE L/S shirt top
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** ** Roxy * ** *Name: top
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Measurements (lying flat and unstretched):
*underarm to underarm length: 16 inches
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-Please make sure all shipping information is correct in your paypal payment. *Canadian winners: pay $20 for shipping and handling via USPS priority mail with a tracking number.
*International winners pay $27 for shipping and handling ... read more


text: A method of identifying user, generating digital signature, and verifying digital signature by selecting a modulus p in the form of p=(2.sup.dk -2.sup.ck -1)/r, p=(2.sup.dk -2.sup.(d-1)k +2.sup.(d-2)k - . . . -2.sup.k +1)/r, p=(2.sup.dk -2.sup.ck -1)/r, p=(2.sup.dk -2.sup.ck +1)/r, and p=(2.sup.4k -2.sup.3k +2.sup.2k +1)/r, selecting an elliptic curve E and an order q; selecting a basepoint G; generating a private key w; generating a public key W=wG; distributing p, E, q, G, and W to at least a prover, a verifier, and a signer; generating the prover's private key w.sub.p and public key W.sub.p =w.sub.p G; retrieving the prover's public key W.sub.p ; generating a private integer k.sub.p ; combining k.sub.p and G to form K using p; sending K to the verifier; sending a challenge integer c to the prover; combining c, k.sub.p, and w.sub.p to form a response integer v; sending v to the verifier; combining cG, K, and W.sub.p using p and checking to see if the combination is equal to vG. If not so, stop. Otherwise, generating, by the signer, the signer's private key w.sub.s ; generating a private integer k.sub.s ; combining k.sub.s and G to form K using p; combining K and a message M to form an integer h; combining h, k.sub.s, and w.sub.s to form an integer s; sending M and (K,s) as a digital signature of M; retrieving W.sub.p ; receiving M and (K,s); combining K and M to form an integer h; and combining h, K, and W.sub.p using p and checking to see if the combination is equal to sG. If so, the digital signature is verified.Cryptographic identification and digital signature method using efficient elliptic curve689828424/05/200509/08/200120051,384Solinas; Jerome A.US Patent and Trademark OfficeGoogle Patent Searchpatentimages.storage.googleapis.com/US6898284B2/US06898284-20050524-D00000.pngUniquedigital signaturew.sub.ppublic key w.sub.psupproververifierintegersignerprivate key w.sub.sprivate integer k.sub.p


text:
Build Guide by miLLaX
Not Updated For Current Season
This guide has not yet been updated for the current season. Please keep this in mind while reading. You can see the most recently updated guides on the browse guides page.
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Lee Sin Build
Ability Sequence
Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Basic Stuff
This build i've been using for a very long time, and it works great for every single match, no matter if its a 3v3, 5v5, normal or ranked. What my build provides is a great amount of damage, early - late game. It also gives a great amount of health, so staying alive isn't a problem.
I'm using a mixed sort of masteries. 21 in offensive to give him the crit and damage bonus, 8 in defense to give him a little more holding in teamfights and 1 in support to give him less cooldown on his ghost.
Skill Sequence
I balance the "Q" Spell and the "W" Spell because the Sonic wave/Resonating strik deals a great amount of damage, and it's pretty much a must to have it as your first spell. Your "E" spell isn't as needed as your Safeguard/Iron will is, because to harrash the enemy without taking to much damage, this is a nice way to use the "W" spell.
There isn't much to say about the Rune choise of mine, only that it has a healthy amount of great bonuses to Lee Sin's damage.
Start off with Doran's Blade and if you aren't dealing as great damage as you might think, don't hold back on buying one or two more. I go with the Tanky-DPS item build, because the build i provide gives you a great amount of damage, and also a nice amount of health.


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by: Staff Writer Patty
I was sent two beautiful polishes from Polish & Co, a brand that was entirely new to me. This is what the website has to say about this company: North Carolina's newest beauty brand where mint juleps, fabulous hats and sundresses reign. Always dreamed of living the Scarlett O'Hara lifestyle? Now, thanks to founder and nail industry expert of 23 years, Theresa Williamson you can have at least your nails emulate that syrupy, southern belle look. Nails are just as important as the latest fashion accessory and can have a large impact on an outfit and a personal general look, so getting them right is crucial. It can take you from messy to polished in a fashionable New York minute.
The shades I was sent were Location, Location, Location and Pink You. Location, Location, Location is pictured below from in my photograph (front and back), a pic of my toes and from the website. This is a true red that is not too warm or too cool. It is just perfect!
I had my toes done on a Tuesday, and I'm writing this on a Tuesday, so this is after one full week of wear with very minimal chipping.
Pink You is a very cool, bubble-gum toned pink. Although I think the color is gorgeous, it was not a suitable shade for my skin tone.
I took both polishes to the nail salon and requested that my toes be painted with Location, Location, Location and my hands Pink You. My feet were done first and the nail technician was very happy with the way this polish went on. She applied two coats and we both marveled at how smooth and even each coat applied. When it came time for my hands, the technician did three fingers with Pink You and I realized it was too far outside of my comfort level so I had her remove it and we went with my old standby, Essie Watermelon.
There are 27 shades on the website, and from what I can tell, most are creamy, non-shimmery shades. There appear to be a few shimmery shades, but nothing with glitter that is so prevalent in polishes these days. This is a sophisticated line with a fun side! They have very fun names like "Sweet Caroline" which is a gorgeous baby blue, a beautiful shell pink (this one actually looks slightly shimmery) called "Oh Hell No" and a dark navy called "Jeans 2 Tight".
These retail for $12USD for .5 ounces of product and can be found on-line at www.polishandcompany.com or at one for their 9 retail locations.
If you're looking for some fun colors to take you into the coming seasons in a good quality nail polish, this line is definitely worth a look!