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cGMP Informatics
IT Infrastructure Design for 21st Century
Pharmaceutical Quality Control and
Quality Assurance Operations
25 South Street The Heath Business & Technical Park
Hopkinton, MA 01748 USA Runcorn, Cheshire WA7 4QF UK
Phone 508.497.9911 Phone 44(0) 1928.513813
Fax 508.497.2396 Fax 44(0) 1928.513822
The pharmaceutical industry is in a state of transformation, driven by two basic challenges: 1) cost reductions as a result of margin erosion pressures, and 2) improvements in compliance documentation and reporting. Both challenges are being addressed by several initiatives under topics including lean manufacturing, right-first-time, six-sigma and operational excellence programs. The foundation of all of these programs is the need to eliminate the non-value added tasks associated with the workforce and workflow at all levels within the manufacturing environment.
At a recent industry conference (1), senior quality operations managers emphasized the importance of the laboratory execution or "work-layer". While the planning and administration layers of a typical pharmaceutical company have been automated with ERP and LIMS respectively, the laboratory execution layer has been either lumped in with LIMS or been left behind altogether. A relatively new technology to automate this laboratory work layer is the Electronic Laboratory Notebook. Within the GMP regulated areas such as QC and Manufacturing, a GMP Electronic Notebook System ensures that only trained analysts/operators can execute only current SOPs and test methods using only approved instruments and supplies. Automating these processes with an electronic platform eliminates the paper-based processes that contribute to operational costs and compliance risks.
This white paper will outline a three tiered IT architecture comprised of an upper layer ERP platform, a middle layer LIMS for lab administration, and a lower layer GMP Electronic Notebook for lab execution. This architecture enables a paperless cGMP Informatics structure that delivers productivity, cost and compliance benefits for 21st century pharmaceutical manufacturing.
A Three Tiered cGMP Informatics Architecture
In a large pharmaceutical production supply chain environment, higher-order IT systems such as Enterprise Resource Planning (e.g. SAP) are considered the global integration hub for managing all operational resources. The ERP system issues work orders for production, which in turn triggers LIMS to assign work and capture results for quality testing (raw materials, in process, stability, and finished product). A QA review and approval process results in lot release.
Traditionally, the laboratory execution workflow is documented on paper, in the form of lab notebooks, forms, data sheets and packets, instrument data binders and supplies/calibration log books. These paper-based processes are the most likely source of confusion and documentation errors. Catching these errors with peer and management review processes, while done to assure completeness and compliance, results in lengthy cycle times. These inefficient processes are thus on the critical-path for improvements.
These manual processes have been identified as the efficiency bottleneck and are the non-value added and often error-prone contributions to the data capture and cataloging process. It is precisely here that the GMP Electronic Notebook layer adds significant value. It eliminates the paper issues and forces analyst/operator compliance consistent with validated GMP requirements at each method step. The workflow tasks associated with each layer of an optimized three-tiered GMP Informatics IT architecture is outlined below:
System Responsibilities in an Optimized 3 Tiered cGMP Informatics Architecture
In this workflow, the lab administration layer tasks are limited to key management level operations (specifications, lot and sample input and reporting), thus eliminating the "customization" and costs required to integrate the LIMS with lab instruments, lab procedures and the important metadata pedigree needed for compliance. The "work layer" is then centralized within the GMP Electronic Notebook layer and fully integrates with ALL lab instruments, methods, supplies and analysts.
This process expedites bi-directional data flow between laboratory and manufacturing operations, while ensuring regulatory compliance and integrated data capture and reporting on a global basis. System responsibilities from table 1 are depicted as a workflow diagram below (figure 1).
LIMS and GMP Electronic Notebook Boundaries
Organizations that have deployed a LIMS have generally used it as an electronic file cabinet to fulfill administrative functions, such as sample tracking and results management. A typical LIMS deployment rarely delivers compelling productivity gains in optimizing laboratory processes. What LIMS excels at is the distribution of critical-path quality results throughout the global QC/QA enterprise. However, a key compliance issue is the primary data and associated metadata produced by the execution of actual test methods and SOP's by analysts and operators (see figures 2 and 3). In traditional LIMS, data such as instrument calibration records and analyst observations are rarely automatically captured during method execution. The importance of this data and metadata cannot be understated, as it represents critical information for the investigation of any failed test that is required for lot or batch release, or a regulatory agency site inspection.
Figure 2
The GMP Electronic Notebook system presents a digital version of a standard test method (STM) to an analyst with automatic capture of data (and metadata) seen in the lower portion of the window. This process eliminates the transcription errors and calculations associated with paper-based notebooks, and is extremely easy to use for the chemist/analyst.
Figure 3
After a method is completed, all data and metadata is presented to reviewers in a dashboard with visual
compliance flags. Flags can alert reviewers to primary data and materials expiration requirements, instrument calibration dates, audit trails, annotations, e-signatures and direct, single mouse click "drill-down" links to the raw data sources.
Today, the LIMS initiatives in the life science industry are focused on launching work (sample administration), storing specifications and final results, and generating reports. Typically, lab or work area results are entered via result entry forms (usually manually) and accompanied by an instrument output report. LIMS are traditionally product-centric at both the corporate and local levels. In comparison, the GMP Electronic Notebook is method-centric. Since nearly every process in a GMP facility is governed by a method, the analyst can use the GMP ELN for all instruments (CDS, balances, pH meters, particle size analyzers, dissolution testers, spectrophotometers etc.) and reagents, standards and supplies (see figure 4). The key business level boundaries are outlined below:
As a final point of comparison, the validation approach to GMP Electronic Notebook solutions is very different than traditional validation approaches used in LIMS and research-based ELNs. Traditional LIMS solutions that are customized to do lab execution tasks require hard coding features that can trigger significant system-level validation efforts, making upgrades and incremental features difficult to validate. The GMP ELN is a COTS (commercial off the shelf) product that facilitates fast deployments and "go-live" operations in cGMP environments. The modular nature of the GMP ELN allows for additional methods, people, and instruments to be simply added with minimal re-qualification required.
Figure 4
The compliant paperless automation elements in the lower portion of this figure are provided by a GMP Electronic Notebook platform. Traditional LIMS functionality is outlined in the top portion (blue shading) of the figure. In a traditional LIMS, the actual method execution and data collection tasks are processed via paper forms with non-value added transcription/translation that must be checked and verified before manual entry into the LIMS. Through integration of the GMP ELN layer and LIMS functions, a paperless and automated GMP informatics platform is realized.
GMP Electronic Notebook Architecture
The GMP Electronic Notebook foundational level is comprised of all instrument connections and network access to any required database for actual test method execution by the analyst. These traditionally include CDS systems, document management systems, calibration software systems, CAPA systems etc. Some of the above functions can be implemented within the GMP Electronic Notebook software, however, a typical installation generally requires interfacing with pre-existing software platforms.
This interoperability is a key component of deploying the GMP Electronic Notebook at the foundation level in any quality operation. The architecture can be connected to your network either in hard wired or wireless fashion. In a secure wireless configuration, an analyst can roam throughout the QC area and access all the components of workflow necessary to run a sample. This includes the currently approved revision of the standard test method, instruments used in analysis, and access to databases (chemical inventory, instrument calibration, etc.). Instruments include chromatography instruments and data systems, balances, spectrophotometers, pipettes, even thermometers. Supporting data such as reagent expiration dates and instrument calibration dates are linked to the record at run time. This is key to compliance management in the lab. All data and metadata are captured and stored not on the tablet PC, but wirelessly sent to a secure server installed for the GMP ELN.
Figure 5
A GMP Electronic Notebook System architecture provides a mobile handheld environment for the analyst to interact with ALL the IT systems necessary for them to complete their lab tasks. They can view the standard test procedure, capture observations and manual data, capture ALL instrument data and metadata...with real-time database cataloging at each method step.
Benefits of a GMP Electronic Notebook Layer in a cGMP IT Infrastructure
To facilitate the "paperless" e-manufacturing environment and to gather consistent quality information while enhancing operational efficiencies, organizations must integrate lab-based workflow automation in concert with their LIMS and ERP layers. This ensures the efficient and productive capture of all method and procedure specific data and metadata in a validated electronic environment.
During routine use of this platform in a validated environment, users chose typical QC processes in simple categories to calculate before/after values and percent savings in resource time. Tasks included:
•Prepare materials and collect results.
•Write-up reports.
•Check & review documentation.
•Approve documentation and results.
•Generate CofA and/or lab report.
Over a six-month time period, the operation experienced savings in most areas, depending on activity and complexity. Overall, the two general results observed were as follows:
•30% reduction in testing resource requirements
•50-75% reduction in review/approval time
These metrics clearly show a large productivity gain by going paperless at the analyst and operator levels and using the data (captured in real-time) to automatically populate the data fields within the higher-order reporting structure (LIMS and ERP). In doing this, the QC lab operation insures compliance with cGMP requirements for electronic data while simultaneously significantly improving productivity and reducing costs. The ultimate benefit of this QC/QA GMP Electronic Notebook System is the reduction in overall cycle times to product release and a "window" into the actual SOP/Method process for any subsequent product/process investigations.
At most life science-based manufacturing companies, management is seeking to improve operational costs and productivity to be competitive and enhance the bottom-line. For decades, most of the data management processes in QA/QC have been "paper-based", requiring numerous non value-added checks to ensure that data integrity and product quality standards have been met. In today's modern computer-based environments, technology can be adapted to totally eliminate these paper systems and replace them with a compliant and fully electronic capture, review and reporting system. In concert with other IT initiatives (e.g. ERP, LIMS, CDS), companies can now adopt a GMP Electronic Notebook data management platform for a paperless GMP Informatics architecture. The notebook fills a niche with a unique capability: the ability to electronically deliver existing approved SOP's to analysts and operators, prompting them to follow the procedure as written, and automatically capture all the method data and outcomes, particularly from instruments. This process eliminates operator errors or transcription problems in working with a typical paper-based notebook.
These analyst-centric operations comprise the GMP Electronic Notebook System layer within thevgreater cGMP Informatics IT architecture . Within this layer all instruments, including CDS, are interfaced with the cGMP Electronic Notebook System and only processed, filtered and approved cGMP result data is transferred to the LIMS and ERP layers. This process has been shown to reduce testing times by 30% and to reduce review and approval time by 50-75%. In doing so, production can approach real-time release of product yielding significant benefits to the overall manufacturing organization and, in turn, the corporation as a whole. Going compliantly "paperless" in the GMP quality control/quality assurance environment is now a reality, delivering significant savings in time and money, as well as improvement in professional job satisfaction for valued technical staff. This three-tiered cGMP Laboratory Informatics architecture provides a platform for 21 st century production requirements for the pharmaceutical and biotechnology industries.
(1) Proceedings of IMACS 2006, May 17-18, 2006, Princeton, NJ (USA) http://www.imacs-world.com
(2) Proceedings of IMACS 2005, May 18-19, 2005, Princeton, NJ (USA) http://www.imacs-world.com
This white paper was written by John Helfrich, Director of GMP Automation Programs, VelQuest Corporation and prepared by Dave Gordon, VelQuest Corporation.
For additional information on GMP Electronic Notebook Systems, please
contact VelQuest Corporation at firstname.lastname@example.com


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Give yourself a pat on the back for a year of hard work. Why not reward yourself this Christmas? We round up some of our favorite Samsung devices in this holiday gift guide.
For more Samsung bundles checkout the Great Samsung Giveaways on samsung.com
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subset: commoncrawl


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August 1, 2010
| Demo
When Princess Gard decided to attend America's Beauty Show (ABS) earlier this year, she had no idea what to expect. Little did she know her entry would not only win her $500, but also a spot on the cover of NAILS Magazine.
August 1, 2010
| Article
Don your berets, because Orly's new Instant Artist Collection promises to help you achieve clean, precise, and colorful nail art designs at every skill level. The collection features 24 water-based shades that each come with a tapered brush for exact placement. The collection also includes four tools: a detailer brush, striper brush, dotter duo, and design tear-off cards that offer suggested step-by-steps.
July 1, 2010
| Demo
Gracia Beauty's Gel System combines functional and well-performing soak-off gels with a nail art sensibility so techs can create endless nail art designs. The gels are available in convenient kits that suit each tech's need, with a basic kit for simple sculpts and Frenches, an intermediate kit for nail art, and full-color gel lines of more than 100 colors.
June 1, 2010
| Article
A clever spin on nail art can come from a simple craft corner border hole punch. AII global educator MaeLing Parrish explains how she spreads soak-off gels flat over a piece of plastic and pops imprints out of them with a border punch. (According to Parrish, she uses soak-off gels because they are soft and flexible and don't crack like traditional gels when they are used with a hole punch.) Take a look at these steps and see if you can score a knockout of your own.
June 1, 2010
| Demo
Akzéntz Classic Gels are high-performance gels that can be combined with the Options Soak-Off Color Gels and Options Aurora Sparkle Gels to produce vibrant nail art designs and structurally sound enhancements.
May 11, 2010
| Product
Light Elegance's new Glitter Gels for the summer and spring come in six fantastic shades.
May 1, 2010
| Demo
If your clients are afraid of this pointy shape, offer up this advice from nail techs who do their best to ensure that beauty doesn't have to equal pain.
Catherine Wong gives NAILS readers a peak into her step-by-step nail art books.
C. A. Therien offers a wide variety of handmade fimo clay canes for beautiful nail art. Fimo canes are easily cut into thin slices, or designs can be purchased in convenient pre-cut packs. Fimo can be encased in acrylic or gel, or glued on top of polish and sealed with a gel top coat.
Young Nails Imagination Art Acrylic Powders can be used to create an amazing variety of nail designs. The powders come in four collections of solid colors, plus five collections of glitters, and they handle well so techs can create intricate designs.
Well, maybe not easy. But Star Nail's global education director Elaine Watson has a quick tip on how to get a better performance out of acrylic for 3-D designs.
May 1, 2010
| Article
When it comes to making edge nails, the most important part of the sculpt is to have a crisply creased form so the acrylic falls perfectly into place and gives you that nice edgy look.
When we asked Orange, Calif.-based celebrity nail artist Elsbeth Schuetz to come up with a toenail art design for this month's cover, she brought us a whole slew of nail tips to choose from. While her hand-painted nail art is always super creative and artistic, we wanted to go with something a little more simple and wearable for the cover. Inspired by tone-on-tone patterns, she created this faux-snakeskin design using layered polish and diamond-shaped rhinestones.
April 1, 2010
| Demo
Dashing Diva's Gelife Soak-Off UV Gel System can be used to make standard pink-and-whites as well as more fashion-forward nail designs such as the "ombre effect," in which the nails gradate from one shade of color to the next.
March 4, 2010
| Product
As the glitter gel toenails craze continues among clients, Light Elegance has released a gel line that makes life easier for the nail techs who do this popular service.
Get the Cat Eye Effect With Gel-Polish7 photos
Readers' Favorite Pedicure Products13 photos
Tony Cuccio is founder and president of Star Nail Products and Cuccio Naturale.
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DENVER -- Troy Tulowitzki looks at his return as opening day, part II.
The Colorado Rockies' smooth-fielding shortstop got off to a rough start before tearing his left quadriceps muscles on April 29 while making an off-balanced play.
Now, he gets a chance to begin again.
Tulowitzki was activated Friday after missing 46 game. To make room for him, the Rockies optioned infielder Doug Bernier to Triple-A Colorado Springs. Tulowitzki finished the game 0-for-4.
"It's kind of a fresh start for me," Tulowitzki said before the game. "I got to sit and watch some games, relax, figure out some things. I'm definitely excited."
The 23-year-old proved to be a fast healer, coming back much sooner than the anticipated All-Star break.
Then again, he knew he would.
"I'm still young, muscles heal quickly and I put a lot of work into it," said Tulowitzki, who signed a $31 million, six-year deal in the offseason.
Tulowitzki is hoping he comes off the disabled list swinging a hot bat, just like Matt Holliday and Brad Hawpe.
Holliday is hitting .368 since he was reinstated on June 10 while Hawpe has hit five of his eight homers after coming back on June 6.
"I'm looking forward to getting him back out there and play and let him get in a competitive routine," Rockies manager Clint Hurdle said of his second-year shortstop.
Tulowitzki was struggling at the plate before the injury, hitting .152 with one homer and 11 RBIs.
He thinks his stint in the minors as he rehabbed the quad injury helped him figure out his flaws at the plate.
Not that he felt that far off. There were signs his swing was coming around even before the injury.
"Obviously, I didn't have my best swing. But I thought I was getting there," Tulowitzki said. "I was definitely hard on myself, maybe tried a little bit too hard at times to get out of it. More than anything, I wasn't very good."
The Rockies were the same way to start the season, but the defending NL champions have regrouped to win 11 of their last 15 games.
"I think we were all struggling at that point and time," Tulowitzki said. "They've turned it around. Hopefully, it's my turn to turn around my season."
In Tulowitzki's absence, the Rockies relied on Omar Quintanilla (27 starts), Clint Barmes (18) and Jonathan Herrera (1) to hold down the position. Barmes has been on the disabled list since May 24 with a sprained right knee, but he could be back soon as well.
"They're playing well," said Tulowitzki, whose team was 20-26 with him out of the lineup. "I'm not going to do anything to win games by myself -- just go in and let the team keep playing how they're going to play and kind of mesh in."
Although the leg feels good, he's not sure what kind of range he'll have. He may not be able to fully extend himself if he has to dive after a ball.
"We'll see," Tulowitzki said with a smile. "It's going to be tough when you get me out there on the field not to go all out. That's the way I play."


text: Sage Rosenfels Former Texans quarterback Sage Rosenfels joined Mad Radio and they talked about the Texans new offensive system and how tough it is, the quarterback situation in Cleveland, how Teddy Bridgewater is doing in Minnesota and could there be a big trade in the NFL soon? MAD RadioMore from MAD RadioComments Leave a Reply Cancel reply Enter your comment here... Please log in using one of these methods to post your comment: Email (required) (Address never made public) Name (required) Website You are commenting using your Twitter account. ( Log Out / Change ) You are commenting using your Facebook account. ( Log Out / Change ) You are commenting using your Google+ account. ( Log Out / Change ) Cancel Connecting to %s Notify me of new comments via email. Notify me of new posts via email. More From CBS Houston DONATE NOW TO HOUSTON FOOD BANKAll of Houston Radio is banding together to support the Houston Food Bank. Donate now.Dynamo Schedule


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I've been sent some .mov files on an external HD, there are about 10 files in total, but I can only view 3 of them. Whenever I try to open the others in Quicktime, it tries to convert them but then I get a message saying that Quicktime can't open it.
I've tried to open in VLC media player, where I can hear the audio, but no visual and get a popup message which says: "Codec not supported VLC could not decode the format "avlg" (No description for this codec)"
I've googled "avlg codec" but can't seem to find anything for it.
Has anybody heard of this codec? If so, do you know where I might be able to download it?
As 3 of the files on the HD are accessible, could it be the other files are corrupt?
I really appreciate any help or ideas anybody may have.
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I had never heard of the 'avlg' FourCC until today either
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Rudolph "Rudy" Giuliani is an American lawyer, businessman, and politician from the state of New York. Formerly Mayor of New York City, Giuliani is currently seeking the Republican nomination in the 2008 United States presidential election.
Rudolph Giuliani was born in the New York City borough of Brooklyn, the only child of working-class parents Harold Angel Giuliani, and Helen C. D'Avanzo, both children of Italian immigrants. The family was Roman Catholic and its extended members included police officers, firefighters, and criminals. Giuliani eventually decided to forego the priesthood, instead attending New York University School of Law in Manhattan, where he made law review and graduated cum laude with a Juris Doctor in 1968
Giuliani was U.S. Attorney until January 1989, resigning as the Reagan administration ended. He garnered criticism until he left office for his zealous handling of cases and was accused of prosecuting cases to further his political ambitions. He joined the law firm White & Case in New York City as a partner. He remained with White & Case until May 1990, when he joined the law firm Anderson Kill Olick & Oshinsky, also in New York City. He served as mayor of New York City from 1994 through 2001.
Guiliani was prominent in the aftermath of the September 11, 2001 attacks on the World Trade Center. He made frequent appearances on radio and television on September 11 and afterwardsfor example, to indicate that tunnels would be closed as a precautionary measure, and that there was no reason to believe that the dispersion of chemical or biological weaponry into the air was a factor in the attack. In his public statements, Giuliani mirrored the emotions of New Yorkers after the attacks: shock, sadness, anger, resolution to rebuild, and the desire for justice to be done to those responsible. "Tomorrow New York is going to be here", he said. "And we're going to rebuild, and we're going to be stronger than we were before...I want the people of New York to be an example to the rest of the country, and the rest of the world, that terrorism can't stop us."
A draft movement began in late 2005 to get Giuliani to run for President of the United States in 2008. Throughout 2006, rumors circulated regarding a possible Giuliani campaign, abetted by hints from the former Mayor himself. In November 2006 Giuliani announced the formation of an exploratory committee. In February 2007 he filed a "statement of candidacy" and confirmed on the television program Larry King Live that he was indeed running.
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TranSwitch® Corporation (NASDAQ: TXCC), a leading provider of carrier-class semiconductor solutions for the converging voice, data and video network, announces the first HDMI® 1.3 Intellectual Property (IP) cores operating at up to 10.5 Gbps (3.5Gbps per channel). The HD-PXL-1.3 transmitter IP core extends TranSwitch's existing offerings in high-performance video interconnect applications and is available in 90 nm CMOS technology.
The HD-PXL-1.3 transmitter IP core is available in two versions. The first version meets all the current HD (High Definition) standards up to 2.25 Gbps. The second version supports serial communications at a speed of up to 3.5 Gbps per channel for extended HD resolutions, with backward compatibility to the first version of 2.25 Gbps.
The transmitter IP core and the DSP-based receiver IP core can run at aggregated speeds of up to 10.5 Gbps and support color depth of up to 16 bits, while providing exceptionally low power consumption and small die size.
"With these IP cores, customers can meet and exceed current market demands with the 2.25 Gbps version, and then drop in the 3.5Gbps cores seamlessly in the future for higher speed. Both the cores have identical features, interfaces, management, and test capabilities, facilitating later upgrades to improve resolution and color depth," said Amir Bar-Niv, Vice President for Systems and Applications at TranSwitch Corporation. "This means customers can bring high definition video transmission capabilities to a myriad of devices today and well into the future without incurring internal development costs and time."
"Based on the results of our HDMI 1.3 prototype testing, we believe it is second-to-none in performance, flexibility, backward-compatibility, and programmability. This design is very sophisticated in that our solution will not only work under worst-case cable and connector conditions, but also has facility for controlling EMI / RFI performance. The cores include a unique set of features, called SI UpswingTM that enhance the control on signal integrity, which is required for data rates above 2.5 Gbps. The transmitter has features for amplitude control, slope control, and pre-emphasis control as well as internal line termination. The receiver also has some unique features including an adaptive equalizer with an accelerated adaptation mechanism, allowing the use of a wide spectrum of cables, connectors, and speeds," concluded Mr. Bar-Niv.
TranSwitch provides a comprehensive package of deliverables to assist customers through all phases of development, design integration and manufacturing of their SoC. This package includes a development platform, as well as all documentation and models of the IP, which allows customers to easily integrate the HD-PXL-1.3 IP cores into complex SoC designs so they can get to market more quickly. TranSwitch's roadmap in this area includes offering these cores in 65 nm technology by the end of 2008 and other products including offerings for DisplayPort as market demands evolve.
"We are excited about TranSwitch's video initiatives through this HDMI offering as it positions the company in an additional fast-growing market with a product that is superior to what is currently available", said Dr. Santanu Das, president and CEO of TranSwitch. "We believe that the video transport business will become a very important growth driver for the company in the near future," concluded Dr. Das.
About TranSwitch
TranSwitch Corporation designs, develops and markets innovative semiconductors that provide core functionality and complete solutions for voice, data and video communications network equipment. As a leading supplier to telecom, datacom, cable television and wireless markets, TranSwitch customers include the major OEMs that serve the worldwide public network, the Internet, and corporate Wide Area Networks (WANs). TranSwitch devices are inherently flexible; many incorporating embedded programmable microcontrollers to rapidly meet customers' new requirements or evolving network standards by modifying a function via software instruction. TranSwitch implements global communications standards in its VLSI solutions and is committed to providing high- quality products and services. TranSwitch, Shelton, CT, is an ISO 9001:2000 registered company.
TranSwitch is a registered trademark of TranSwitch Corporation. HD-PXL and SI Upswing are a trademark of TranSwitch Corporation. HDMI and High-Definition Multimedia Interface are trademarks or registered trademarks of HDMI Licensing LLC.


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Through the phone he sounds like a baby still, his voice all treble and long vowels that twist up, sing-songy, with excitement. That voice, disembodied and modified as it filters through my earpiece, reminds me of the two year old version of this, my oldest, son. I see him in brand new glasses, so tiny in my hand I could not believe they would span his face, and his hair long and shaggy as it was back then. And he is talking with a soft lisp in the background of my phone conversation with his father, this almost seven year old boy, and as I listen, nodding, I am marveling at how young he sounds. Still such a small thing, so easily crushed and just as quickly puffed back up with joy again.
He tried out for a part in the first grade play this week. He worked all week to learn the story of Francis Scott Key, reciting the story of how our national anthem came to be, and his father would say, "Yes, that's good. You remembered all the parts, but do it one more time and speak slowly." Then our boy would stand there, so tall and straight, eyes wide beneath the sixth incarnation of eyeglasses since that toddler first learned to wear the things, repeating the story of the famous flag waving in the dawn's early light. Each word so carefully reigned in, except the name Francis Scott Key, which always came out a-jumble.
In my mind's eye, I saw him getting up in front of the class for his audition, saw his words tumbling out, tangling up in each other in his excitement. And I laughed under my breath, knowing his eagerness would overtake him as it always did, knowing he would remember every little detail, that he would move his hands just like his father does and he would be wonderfully animated. He would get all the rest of it right and yet his words would come tumbling out and bumping into each other no matter how many times he'd practiced it s-l-o-w-l-y.
~ ~ ~
The elevator stops at every floor to let someone on, beeping cheerfully as it opens its doors to welcome new passengers. By the time we reach the main level, we have all shuffled close enough that our bags and the jackets slung over our arms are brushing the backs of the strangers in front of us. It's been spitting rain off and on all day, the perfect recipe for a long Friday commute home. The lumbering elevator is just one more thing standing between me and my boys. The lumbering elevator and every other working stiff stuck in a car on northbound I-35 between downtown and suburbia.
Hurry up and wait. We run to our cars to sit on the thin upholstery at 15 miles an hour. Adjust the air conditioner, fiddle with the radio. I yearn north and east, ten miles down the road to where my family waits for me. I talk to Sam on the phone to pass the time, and our oldest is saying in the background, "Don't tell her, dad! Let me tell her!" And I know from his excitement that he got the part, that he remembered all the details and rushed through the audition and got the speaking part in the school play. In the center of my chest, heat gathers: my pride is a warm constriction around my heart, a sweet pain in my chest. The sedan in front of me taunts me with emotive break lights, moody syncopation that reminds me I am not home yet.
~ ~ ~
The internet tells me Michelle Obama wore a gown by a designer named Tracy Reese when she stood in front of her party's convention and named her most important role as "mom-in-chief." I learn that she kept the couture grounded with J Crew heels, and that those same heels can be mine for an every-woman special price of $245. But, it seems, the internet hasn't decided what to make of that mom in chief business.
I drive home thinking of the politics of motherhood, a race no woman wins no matter which side she campaigns for. My own discount pumps are nearing the end of their life, and I know that even before I've hugged my boys, I'll have slipped them off and kicked them recklessly just out of the walkway in the kitchen. They've been pushing on the old unhealed wound in the arch of my right foot, but what can I expect from a pair of shoes that cost less than the tax on the first lady's version of discount footwear.
And as soon as I'm free of the shoes and my feet stretch out, flattening into the cool tile of the kitchen floor, my boys will see me and scream Mom! as they run for me with arms open like some happy reunion scene in a movie. They will bowl me over with hugs, and Sam will wait, just a little begrudgingly, for his own hello kiss while our kids press their dirty t-shirts against me and repeat mom, mom, mom over and over again.
I cross the threshold, step from one role to another, and become mother in the twenty steps from car to kitchen. All the reassuring protocol of the professional world dissolves, and though I should feel the weight of responsibilities lift from my shoulders, instead I take on the tremulous identity that is both infinitely lighter and heavier all at once. This is by far the trickier role, and also the more rewarding. And there is something more, something ingrained about it. This is who I am. I must perform certain duties as mother of these children, but ultimately I am so keenly, starkly myself with them that I realize how much more of myself I understand now than I did before I had children. They were part of me, and it feels as if they still are, though they prance about on the outside like the umbilical cord is not still pulling at my abdomen.
This is coming home. This is coming home to myself, kicking off the outward face and wrapping my arms around my life.
I imagine the first lady slipping out of her for-the-people heels, too, replacing her designer gown with some elastic waist pants and putting on her mom-in-chief hat. I wonder which part is the slow elevator ride for her, which part is the Friday traffic. What keeps her from her children so long she starts to yearn toward them like a magnet being held an inch from the refrigerator door?
I relax into the arms of my boys, breathe in their dirty hair and pat their little backs. All evening, we do nothing but play, lounge, read stories, and have music around us. Nothing productive is done and yet we fall into bed, tired and half-smiling still. In the morning, the boys will climb into our bed and burrow beneath the covers. I will feign irritation, but secretly I will breathe a contented sigh so deep the knots in my shoulder will unclench and disappear into my pillow.


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29 Dec 2014 by Marina Shaw
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Nothing is more romantic than a St Valentine's Day proposal - and acceptance. The next big question is: where to find the perfect dress? The answer is: Boston, Massachusetts. On February 18, Filene's Basement stages the "Running of the Brides" (below). This annual sale of wedding dresses was first held in 1947 and it has all the cut and thrust of an Olympic final.
Picture the scene. On a bitter night, women queue up around the block. Inside the store are 2,200 bridal gowns. Originally priced from £500 to £5,000, most are reduced to between £130 and £265. Many carry designer labels such as Carolina Herrera and Vera Wang.
At 8am, the doors open. Some 60 seconds later, the rails are empty. Tactics are simple. Forget handbags, high heels and make-up. Wear trainers and leotards, ready to strip off and pull on dresses right there on the shop floor. Because gowns are not organised by size, no one can hog the size 12s. Grab an armful, then bargain with fellow brides-to-be. Swap a size eight for an 18; strapless for long-sleeved.
This year, rumour has it that somewhere on the rails is a £6,500 Vera Wang creation in the sale at just £370.
- Filene's Basement, 426 Washington Street, Boston (001 617 348 7848, www.filenesbasement.com). Filene's Basement in Union Square, New York City, has a wedding-dress sale on March 4. The Boston store holds a second sale in August. On the night of February 17, the Hyatt Regency Boston hotel, close to Filene's Basement, has a 'Running of the Brides' package: £107 for a double room for the night, including Power Breakfast and tips on how to find the perfect dress (001 617 912 1234, www.hyatt.com). Picture: patriot ledger


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Str. Shakespeare's 9/1 Trailer (2014)
29 September 2014 Comedy 19 mins
A young couple, and their 6 year old son, are trying to find a building so they can check out an apartment that they want to buy. After they have found the building, and the apartment, they discover that the old land lady have past away.
Watch the official Str. Shakespeare's 9/1 2014 trailer in HD below or find more Str. Shakespeare's 9/1 videos on Vidimovie.


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The first employability programme for Skills for Security is great success
Skills for Security's new trailblazing employability programme kicked off this month in what has been a spectacular start with the first sessions fully booked and further applications being made each day.
The employability programme takes unemployed people through a six week course which gives them the skills required to enter the security industry. The programme teaches them interview skills, customer service skills and security specific knowledge culminating in an interview with an employer looking to recruit.
Derek Jones, National Employer Engagement Manager at Skills for Security said:
"The first sessions have been a roaring success. The candidates have demonstrated a superb attitude and a real commitment to learn. We are on target to have a full house completing the qualification and ready to impress at the interview stage. The recruiting employer has expressed their delight with both the standard of the learners and with the course content."
Skills for Security Employability programme originated following discussions with the security industry about how to attract new talent into the security industry and the difficulties faced in recruiting high quality candidates.
The aim of the programme is to provide employers with a selection of individuals who are job ready, engaged, motivated, knowledgeable and with a good work ethic.
Derek continued:
"The programme was developed in conjunction with employers. They advised on the standards and skills they look for when recruiting and the course was tailored accordingly whilst still using nationally recognised qualifications."
On future programme Derek added that:
"We are currently in discussions with other Security companies and have a further two programmes in the pipeline proposed for London and Birmingham.
However, we are able to deliver anywhere in England that has a need for security personnel, so long as the partnership between the employer and ourselves develops the learning aims for the individuals."
If you would like to know more about the Employability programme or forthcoming opportunities or you are an employer who is looking to develop a bespoke recruitment or training process, please contact Skills for Security at email@example.com or on 01905 744000


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Foo Fighters Rickroll Westboro Baptist Church
Leave it to Dave Grohl to protest hate speech with a 2007 Internet meme.
Leave it to Dave Grohl to protest hate speech with a 2007 Internet meme.
So I've learned some news that many are finding disturbing. Have you ever heard of Westboro Baptist Church? Well, according to their press release, they are about to make a stop in Amarillo. Why? To protest the funeral of Genaro Bedoy, a River Road High graduate that died in active duty while serving in Afghanistan. Are you seeing red? Just wait, it gets worse.
When the Westboro Baptist Church announced their intention to target the funeral of Texas A&M alum Lt. Col. Roy Tisdale, his fellow Aggies didn't take it sitting down.
In fact, with a little help of Facebook, more than 500 students at Texas A&M showed up at the burial in College Park, Texas.


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Annie Build Guide by Contradictions
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AP Mid Annie
Annie Build
Starting Items
First Back (General)
FIrst Back (vs AD and struggling)
First Back (Kicking butt, taking names)
Other Optional Items (Generally Not good XD)
Ability Sequence
Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Hello Mobafire :D My IGN is Contradictions, and I've been all over the Elo world. I didn't begin playing ranked until Season 3, where I placed Bronze 5 and spent most all of my time that season in Bronze, eventually ending Silver 2. I've been consistently Gold+ since then, and haven't played much ranked recently. My goal with this guide is to introduce those players who are struggling at lower elos much like I did to a champion that saved me from said lower elo: Annie. She'll get the job done :3.
Recent Changes: Why Annie Mid can help you
With recent changes to the jungle and changes to Annie's kit, Annie mid is shining more so now than ever! Unfortunately, with the recent loss of Deathfire Grasp, Annie doesn't have as much single target burst as she did before. On the bright side, she received much more that makes her better. The changes to her Q allow her very accurate and consistent farming that can also be used to build quick stacks on her passive. The changes to the jungle generally prevent extremely early ganks, especially at lower elo. Thus, one of her most glaring weaknesses is virtually gone :D
Pros / Cons
Annie is a mage who struggles primarily with mobility.
Very High burst damage at all points of the game
Amazing AOE stun that gets stronger as the game progresses
Armor/MR buff that helps her survive and trade
All of her abilities can stun (except for her shield), allowing great versatility with your CC
Tibbers can tank objectives, allowing easy dragons and towers
Great mana sustain with the Q mana regen
Very easy to pick up and learn... ANNIEbody can play her! HUEHUE
Low mobility can cause her to be harassed by champions with skill shots
Susceptible to ganks, particularly those in early game
Weaker roam compared to other highly mobile Mid laners
Relies on Flash for the best engages
Blowing your stun without thinking will probably get you killed
Blowing your spells constantly will also blow all of your mana, so watch carefully
The higher your elo gets, the more predictable you get :(
Annie's Awesome abilities
Pyromania: The passive that makes Annie so awesome. Pyromania allows you to stun your opponents with your spells every 4 spell casts. The amount of time that your opponent is stunned scales with your level. What makes this passive so amazing is that it applies to all of your abilities, meaning you can stun with your Disintegrate, Incinerate, or Summon: Tibbers. Understanding which to use in which scenario can be crucial to your damage and cc output in Mid lane and in team fights. If you juggle usage of your abilities correctly, you should be able to get in at least 2 stuns in a single team fight.
Disintegrate: Annie's Q is her main farming tool, and your safest tool to land your stun since it's a targeted ability. Killing a minion with Disintegrate refunds the mana cost entirely. Combine this with Doran's Ring and blue buff to sustain your mana in lane. It's also important as your primary tool to land your stun when bullying in lane. The cooldown is actually so low that when you have Cooldown masteries and land the killing blow on minions, you can farm safely and accurately even under turret!
Incinerate: Annie's W provides a great amount of AOE damage, as well as an AOE alternative to Summon: Tibbers for your stun. Other than Summon: Tibbers, this is your highest damage move, and most costly Mana wise. Be sure to aim carefully in team fights, as this move combined with Summon: Tibbers is generally enough to burst down most ADCs and AP mids who haven't built MR once you reach late game.
Molten Shield: Annie's E provides Armor and Magic Resistance, alongside a free magical thornmail! Using this ability during trades and teamfights minimizes the damage Annie receives from her opponents. It can also be used for a stack on your passive if you feel safe in lane or are on your way back to lane. The mana cost is minimal, so don't be afraid to use it if you don't feel you'll need it.
Summon: Tibbers: Ohhh mannn.... the skill that makes Annie the god that she is. Tibbers is a monster in teamfights, boasting an additional auto attack and a natural Sunfire Cape that scales off of your AP. Summon: Tibbers is generally the primary initiation tool for Annie, especially in teamfights. Tibbers finds even more use outside of teamfights, where he can be used to tank objectives for the team, such as Dragon or Towers. The cooldown may seem high, but if Tibbers sticks around for the full duration of his lifespan, then you'll notice a dramatic reduction.
Basic AP:
Greater Mark of Magic Penetration
Greater Glyph of Magic Resist
Greater Quintessence of Ability Power
Greater Seal of Armor
Full on burst:
Greater Glyph of Ability Power
Greater Mark of Magic Penetration
Greater Quintessence of Ability Power
Greater Seal of Health
Auto attack heavy:
Greater Glyph of Magic Resist
Greater Mark of Precision
Greater Quintessence of Ability Power
Greater Seal of Armor
Other optional runes: If you have trouble keeping up with your Mana, you can run mana regen runes as well. Movement speed runes are also entirely viable to help with laning, roaming, and running for your life. Cooldown reduction runes are also viable. All in all, your runes generally will fit to your playstyle, so experiment and find what you like!
My typical Masteries for Annie:Annie. Expose Weakness is great for your teamfighting, while Arcane Blade works wonders since you're auto attack heavy. The rest of the Offensive side is for your AP Burstiness. Recovery will help you to stay in lane just a bit longer, while Enchanted Armor scales not only off of Zhonya's Hourglass and other MR items you might've built, but it also scales off of Molten Shield. It's not that much, but with minimal armor stats already, it plays a small part. Fleet of Foot helps with your terrible movement speed, while Meditation helps sustain your mana. All in all, this is the safest set of masteries that I've used.
A bit more Utility Summoner's Insight decreases the cooldown on Flash and Ignite, allowing you to do your Flash into Summon: Tibbers more often.
Survival of the Anniest
You're pretty much always going to want these spells with you as mid Annie. Ignite is too useful for securing kills, while Flash is literally a necessity for Annie.
: if you're THAT intent on not taking Ignite, then atleast run something that Annie will find useful. Heal helps with escapes from ganks or from a mid laner who's about to kill you. It's not a horrible alternative, just nowhere near as useful.
: Again, not a horrible spell to take, just far undermined by the use of Ignite. Since Annie has poor movement, Teleport can be used for quick ganks or quick returns to lane. You'll just be losing out on a lot of kill potential.
: If you constantly find yourself having trouble with champions like Zed, Riven, or Yasuo, this isn't a bad alternative. If someone jumps on you, you can Exhaust to reduce their damage, attack speed, and movement, allowing you to work around them. It's also useful to use against other damage dealers, like fed junglers who come to lane wanting to cut you to pieces, or fed ADCs who are terrifying.
Skill sequenceAnnie, particularly if I'm winning trades and are coming out on top. Smart use of your Disintegrate will allow you to poke your opponent every time your stun comes up (which is basically every 4 minions). Giving it a quick second level will allow you to come out strongly in trades.
If you find yourself mostly going even, falling behind, or against a jungler who is more likely to gank you almost instantly, instead use this sequence:
Picks and Bans: Is there something special I should do for Annie?
Generally, you don't have to be afraid of being counter picked as Annie, even if you're first pick. A lot of times, it'll be assumed that you're support, unless another more likely support shows up. Even then, If there's any champions that truly bothers you, be sure to let the person who's banning know so they can help you out.
Annie Combination Attack
So I'm assuming you already understand Annie's abilities enough at this point to see how to combo with her. Your stun ability starts your combo, followed by your other damage abilities. Your basic poke combo is Disintegrate when your stun is ready, followed by a quick Incinerate, then you back off. You'll want to start your kill combo with Summon: Tibbers(especially in teamfights), followed by an Incinerate, then Disintegrate. IF your opponent is highly mobile, or able to quickly go into stealth, it's generally better to start with your target ability, Disintegrate, as the stun, then go into your other abilities from there. Summon: Tibbers and Incinerate can still hit stealth. It's generally best to use Molten Shield AFTER your stun ability so it applies a stack to another round of your passive, Pyromania.
A good trick to use with Annie, which I'll codename "3rd Strike" because that sounds really cool, is to use your Disintegrate when you're at 3 stacks of Pyromania, then use your Molten Shield before Disintegrate makes contact. You'll reach 4 stacks, still causing the stun, even though it appeared you had no stun ready. Some experienced players will know to watch Annie even when she has 3 stacks, so it's more useful situationally.
General Gameplay tips
1. When I say use auto attacks frequently, that doesn't mean auto in their minions - If you use the auto attacks to close to their minions, you'll take minion aggro, which will hurt far more than your pesky little fireball. Be very careful.
2. Don't be afraid to 2v1 if you get ganked at level 6 or higher - Annie has a very strong 2v1, so if the jungler comes in at level 4 and you're level 6, you'll actually stand a good chance of taking out both the mid laner and jungler, so long as you don't let yourself get chain CCed. Molten Shield helps you tank and you can land a stun on both. gg ez.
3. Tibbers is a useful tool outside of damage - I've said it a thousand times, but Tibbers is great for tanking objectives. Just finished a fight contesting dragon? Have Tibbers tank that mofo. Just killed your mid laner and want to try and get some damage on the turret? Have Tibbers tank that mofo. Mid laner running away with a sliver of health? Pop that Molten Shield and watch Tibbers burn them to death. He's very useful outside of his initial explosion, so don't forget to control him!
4. Just because you're the burst mage doesn't mean you have to take all of the kills - take a hit for the team and use all of your stuff to engage if you have to. Setting up 5 kills for your ADC is far better than blowing everything for just one kill for yourself. Share the love!
5. Fear and respect the Enemy Jungler - Don't play carelessly. Annie is able to be easily ganked in her early game pre 6, especially by junglers who gank early like Jarvan IV or Rek'Sai. Keep vision control of the area around middle lane so your team can see as well. Knowing where their jungler is allows you to counter strike, and keeps you safe. A Sweeping Lens can help you keep control of enemy vision, letting your jungler help you easier. Wards don't cost THAT much, so buy them frequently :D
Item builds
General start
There's not much reason to start anything else. Doran's Ring helps you not only with health, but with mana regen and AP. The Health Potions keep you alive. Enough said.
Funny start
Hilariously enough, this actually works. I don't suggest it, since you'll have to be prioritizing your auto attacks far more and it'll be harder to keep up your mana, but you can if you want.
Core Items
These 5 items are the general core of my Annie build.
: This is your general go to set of boots. They provide a good movement speed boost, and give you flat Magic Penetration, which is great for any AP Mage. It's honestly quite useful to rush your Tier 2 boots, particularly against skill shot champions such as Brand, Ahri or Cassiopeia. A nice alternative is Boots of Mobility, since they'll allow you to roam easily to other lanes. I only suggest that alternative if you have a ridiculous lead.
: This is a fantastic item for almost any mid laner. It provides Mana Regen, CDR, a good chunk of AP, and grievous wounds for very cheap. A must have if you're against Dr. Mundo or Swain, but can be replaced by Rod of Ages or Athene's Unholy Grail if you would rather have more health or magic resistance over CDR respectfully if you're not.
: An amazing item for any AP burst mage, but even more so on Annie thanks to her insanely high AP ratios. There is literally no reason not to get this item.
: This is a fantastic item that makes your damage skyrocket. Combine this with Rabadon's Deathcap and you'll be able to burst down anyone mid game. Another absolute must have.
: A useful item with a useful active. If you're against an AD mid who you're having trouble with, I would actually build the Seeker's Armguard before anything else, then finish Zhonya's Hourglass later. If you're against no AD at all, this item can be replaced. The active is very useful after you've initiated, you get jumped on, and your abilities are on cooldown.
Your sixth item/Alternate Items
Most of these items are at least decent on Annie, but mostly situational in my honest opinion. Choosing your sixth item can be fairly tough, but any item is more useful than no item :P
: If I get down to my sixth item, I generally either go for this one for the extra Magic Pen, health, and burn effect, or Rylai's Crystal Scepter for the health and massive AP. Liandry's Torment is useful against champions with high HP such as Sion or Dr. Mundo, and the burn istacks alright with the natural Sunfire Cape of Summon: Tibbers, but it's definitely not a priority item.
: A decent alternative to Morellonomicon, and honestly not a bad standalone 6th item. However, if you intend to build it, it'll have to be your first item. It will help if you're having trouble surviving in your lane thanks to catalyst the protector, but I honestly feel as though it's overshadowed by other items once late game comes along.
: A decent item at best, and an alternative to Morellonomicon. The miniscule AP and MR are really not worth it for how expensive it is. A drastically nerfed item that's only useful if you're being absolutely dominated by an AP and need Mana Regen.
: A great item that finds minimal use in Annie. Most of the time, your abilities are used to stun your opponents, so the slow wouldn't even be noticed. Still, once late game comes around and you're spamming your abilities, you'll finally notice that slow XD A great boost to AP and health as well is very useful, making it a great 6th Item choice, or an alternative to Zhonya's Hourglass.
: Oh boy. This is a fun item, but it is virtually useless in ranked play. It's like putting a big sign on your face that says "Please kill me". If you're really feeling confident and have a huge lead, then by all means. Much more fun to use in Normals.
: A fun item to use against an all AD comp. Not only will this be dealing damage back on auto attacks, but so will Molten Shield. Finds literally zero use outside of those circumstances though.
: A decent item with minimal use. You generally want more damage when playing as mid Annie, but if you feel like you have enough damage and want an easier time surviving, this item could do the trick. Makes for funny wake up stuns.
: An item that looks cool on paper, but isn't all it sounds it could be. Abyssal Mask contradicts the effects of Void Staff, so the only reason you'd have for building it is against a squishy team with Heavy AP instead of Void Staff.
: another neat item on paper, but generally not worth it. You'd have to get an early Tear of the Goddess, and build it up, which isn't so hard. Unfortunately, Annie wouldn't build any other Mana items, so the mana regen is nice and all, but seraph's plume wouldn't scale as much as it would, unless you intended to build Rod of Ages.
: A funny 6th item, Lich Bane is honestly not your best choice, but can help with quick burst if your combo isn't doing enough. Also adds to mobility.
Early Game: What do I do against who?
To make things simpler, I'm going to order these in order of difficulty. Keep in mind, this isn't based entirely off of who actually counters Annie as much as it's based on my personal experience against these people.
Easiest... Like... Piece of cake... Level 1
: You have a better stun and more reliable poke. The only thing that can keep him in lane is his Crystalline Flask and Pick A Card, which will sustain his health and mana for a decent amount of time. Be sure to bully him often, as he'll try to poke back with his Wild Cards. Just dodge the skill shot and it's a guaranteed win. Be very wary of Jungle assistance though, as he can set up a gank fairly well with his Pick A Card. Once you've hit 6, he'll have literally no way to out burst you, and he'll be the easiest kill in the world. Once he's hit 6 though, be sure to keep wards on either side of the river and let your team know if he's gone MIA, so he won't get the jump with Destiny. If you play it right, you can chase him and cancel Destiny with your stun. It's hilarious XD
: You probably won't see this too often, but if you do, be ready to wreck his face. Ryze has fairly devastating poke with his Overload, but don't worry. If you use your Disintegrate and Incinerate combo wisely, he can do nothing but take the heat. Just don't let him constantly hit you while getting nothing in return. He's easy to trade pre 6, especially before he gets any items. If you've poked him down enough, he's a free kill level 6.
: Your fire is a thousand times more potent than this guy's. Brand packs quite a punch if you let him hit his abilities, but if you focus primarily on dodging his skills, you can punish him dramatically for his misses. Since he uses mostly skill shots, I'd rush Sorcerer's Shoes, or atleast Boots of Speed. Watch how the Brand you're against primarily utilizes his Pillar of Flame. If he throws it directly at you, focus on stepping out of the way. Don't worry if he lands a few pillars at early levels, since it won't be at it's full effectiveness. If he throws it behind you (which is the most likely alternative), just walk towards him and hit him with your 1,2, punch combo: Disintegrate into Incinerate. He's another easy kill once you hit 6, but don't underestimate his burst and just walk blindly at him, because he'll be able to land his full combo on you easily.
: Fairly similar to Brand in playstyle, except she trades some damage for an obnoxious shield. Watch her Lucent Singularity, which she'll use to harass you. Chances are, she'll throw it behind you, so if she does, walk towards her and punish her with your Disintegrate into Incinerate combo. Be sure to poke her down a bit before you go all in, because if you aren't careful, you'll blow everything on trying to kill her only to have her use Prismatic Barrier after the stun wears off. Her poke can be insanely painful if you aren't careful. Get early boots and dodge all of her skill shots. Let your team know if she leaves lane and where she's going, so she can't pick up kills on your team with Final Spark. EZ PZ LEMON SQUEEZY.
: A very easy matchup, as long as you get those early Boots of Speed. Watch her Grasping Roots, for if she lands that, you could be in for a world of hurt. Similar enough to Lux and Brand in playstyle. Dodge her stuff, punish her when she misses. Stay out of the range of her plants though. Your Disintegrate can finish them quick. Easy kill level 6.
: Another easy win, so long as you don't mess up your initiation. Vel'Koz is a kiting machine, so if you just walk straight at him, he'll pulverize you with his combination of Tectonic Disruption - Void Rift - Plasma Fission - Life Form Disintegration Ray, which will most likely be enough to end you. Watch when he goes for farm and use that moment to bully him. Use short trades to slowly get ahead. He'll use Plasma Fission a lot to try and poke you. It's fairly unpredictable, so it's most likely atleast a few will hit you. If he goes on the offensive, focus first on dodging his abilities, then he's a sitting duck. If you've played right, he's an easy kill at level 6.
Fairly easy... Level 2
: he would honestly be a lot scarier if he still had his silence. Talon is pretty likely to try and poke you with his Rake. It's not the easiest skill to dodge, so getting an early Seeker's Armguard will help you win your lane easily. Harass him from a safe distance with auto attacks. If he decides to jump in with his cutthroat- Noxian Diplomacy combo, use your Molten Shield as soon as possible and trade back. Try to save your stun specifically for when he decides to jump on you. That's the easiest way to take him out. If you let him get ahead of you, you'll explode pretty much constantly.
: as much as I hate this guy, he isn't so hard for Annie to handle. Using a combination of your long auto attack range and Disintegrate, you can shut down his use of H-28G Evolution Turrets. Consider them free farm, and continue to harass him when you can. Get early Boots of Speed so you can dodge his ch-1 electron storm grenade. He's easy enough to burst down if you're consistent with your bullying. Dodging his stun is priority, however, unless you can get the jump on him with Flash.
: Viktor is a fairly easy lane opponent. His Death Ray won't start hurting until later in the game, so try your best to avoid it and bully him. If you see him trying to use Siphon Power, let the shield wear off, then trade back. If you can dodge his Gravity Field and Death Ray, he's not too hard. Let him get ahead, however, and he'll out burst you. Take an early Boots of Speed to help with dodging his abilities. If you burst him fast enough, he won't even get to use Chaos Storm.
: As obnoxious as he is, Kennen actually isn't all that scary. As long as you keep behind your minion line, he won't be able to hit you effectively with Thundering Shuriken, so his only real way to poke you is his combination of empowered auto attacks and Electrical Surge. Letting him land his Mark of the Storm spells trouble for you, so if you need to, back off when you have stacks on you. If you see him moving around his minion wave to hit you with Thundering Shuriken, move around with him so he can't hit you. Use of your stun and auto attacks to mess with him will keep you ahead. His auto attacks will hurt a bit more than others, since he generally will start with Doran's Blade, but that makes his spells weaker. If you hit 6 first, be sure to kill him as soon as possible, and it'll all be downhill from there. Try to stun him and trade outside of Lightning Rush, because that gives him an Armor/Magic Resistance buff.
: Despite him being terrifying to most mid laners, Annie surprisingly doesn't have too hard of a time. As with most AD mids, rush a Seeker's Armguard to minimize his poke. If you ever see him oom, that's your opportunity to lay into him, especially before he get's Tear of the Goddess. Try not to spam usage of your stun, for it's better to save it for when he tries to engage on you in melee range. Stay behind your minion line, but not too close, so you can avoid his Acceleration Gate - Shock Blast combo. Your auto attack range is actually higher than his, so auto attack frequently when he's trying to farm. If you see him activate Hyper Charge, back off, and let him use it on minions. If he engages with To The Skies!, that's your chance to land your stun and trade, especially if he's dumb enough to jump into your minions. If he does try to all-in you, make sure to use your Molten Shield so he hurts himself. Your level 6 is far stronger as well, so you should win easy if you'd been going at least even.
: A generally easy win. If you let her dash in on you with nothing to protect you, however, you'll probably die. Be EXTREMELY aggressive pre-6, as the best thing she can do is throw a Mark of the Assassin at you and try to auto off of it. She's one of the few where I'd suggest beginning your initiation with a Disintegrate stun, followed by the rest of your combo. Even in her veil, Tibbers can still eat her alive, so it's pretty much a free win once you've landed your combo. Even if she decides to jump on you, just pop Molten Shield and kite into Tibbers until your Disintegrate and Incinerate come back up and finish her off. ALWAYS call MIAs, as her roam can catch her up.
: A fairly easy lane matchup, since her primary form of CC is extremely slow. Be sure to bully Anivia VERY early, and try to atleast remove her Rebirth passive. Once she gets her catalyst the protector, it'll take a lot more to wear her down. As long as you can constantly keep her bullied out of lane, this is an easy win. Take and early Boots of Speed so you can dodge her Flash Frost, and apply constant pressure. She's EXTREMELY squishy and susceptible to ganks early. Use that time to shut her down so she's useless.
: This guy is little more than a nuisance. You out trade him as long as you dodge his Essence Flux (or if he's AD, his Mystic Shot). Bully him constantly and he'll be an easy kill level 6. One of the easiest to burst down. He'll use his Arcane Shift too late every time, especially if you use Flash to set up your stun.
Getting a little harder... Basically skill matchups... Level 3
: despite being a melee champion, Katarina can actually kill you more easily than most other mids. It's best to save your stun for after her Shunpo - Death Lotus combo so you can cancel her ult and basically nullify her damage. Worst case scenario, you'll use Summon: Tibbers the EXACT moment she uses Shunpo, which guarantees her win. Not worth risking it. If you happen to not have a stun, at least have your Molten Shield for when she all-ins you. Harass her primarily with auto attacks, but be weary of her poke with Bouncing Blades. Use Disintegrate before your stun is up to not only poke her, but bait her into engaging onto you. If she jumps on you when you have your stun, you win, but if you blow it and don't kill her fast enough, she wins. Early aggression is your friend. She's also a far stronger roamer than you, so always watch where she leaves from and call your MIAs.
: Fairly similar to Katarina, Fizz can dodge your stun with his Playful / Trickster, then safely engage onto you. Harass him constantly with auto attacks. Funnily enough though, when you use Disintegrate and he uses Playful / Trickster, your ability will go on cooldown, but you won't lose your stun. Use this little exploitation to your advantage and always begin with Disintegrate. If he doesn't use Playful / Trickster, poke him with Incinerate, then immediately back off. If he does, bide your time for him to drop, then immediately use your stun on Incinerate or Summon: Tibbers before he can Chum the Waters or Urchin Strike. After your stun and damage hit him, he'll either A. continue trying to engage on you, or B. Run like a scared magikarp. Once you land your abilities, juke sideways to prevent his Chum the Waters from hitting you, and pressure him hard. Ping your MIAs, since his roam is strong.
: Here's one who can absolutely annihilate you if she knows what she's doing. Fortunately, most people in lower elo don't. Take early Sorcerer's Shoes so you can dodge her constant streams of Command: Attack - Command: Dissonance. If she sees you have your stun and you walk toward her, she'll likely use Command: Protect. Wait for the shield to wear off, and use that time to attack her. She's far squishier when she's on the offensive, so your best bet is to dodge her abilities and then poke her. You both have very strong level 6, so always play carefully. If you get an early lead, capitalize on it and murder her constantly. She's a fairly easy kill, especially if she goes for Tear of the Goddess over Chalice of Harmony.
: This one can be surprisingly annoying. Her Crescent Strike begins to hurt very quickly, and her use of Pale Cascade can prevent a good chunk of damage from your poke. Use the 3rd Strike to prevent her from using the Pale Cascade shield to block your stun damage. If she does happen to use her shield, just stay at 4 stacks and wait for another opportunity to use Disintegrate. Gr8 B8 M8. Her level 6 can be quite frightening, especially if she's been good at landing her Crescent Strike. Use early aggression with your auto attacks to try and come out on top, and always dodge her abilities to your fullest.
: While not as scary as she once was, Kayle generally performs well against particularly bursty champions, especially someone like Annie with a very predictable stun. Use auto attacks early on, especially when she doesn't have/can't use her Reckoning or Righteous Fury. This is where use of the 3rd Strike comes in handy. Once she hits 6, weaken her with your Disintegrate - Incinerate combo, then use the 3rd Strike to stun her by surprise and finish her off before she can use Intervention. Her poke is strong over time, so just back off if you know you can't trade with her. If she ults to block your damage, you won't be able to kayle her (HUEHUE), so play it smart.
: Seriously. This guy is just a small annoyance. Auto attack constantly when his Iron Man shield is down. Ask for a gank early and get an early lead. Even his Iron Man passive won't save him from your fiery wrath. Watch how much of a shield he has available, and trade when it's near empty to empty, while staying out of the range of his Siphon of Destruction. He's free kills for your jungler, so just pick on him by saving your stun for ganks.
: An annoying mobile AD Mid, Yasuo can be a real hassle. Harass him with auto attacks, especially when Way of the Wanderer's shield is full. If that shield is on cooldown and he has one or less stacks of Steel Tempest, feel free to use your stun to trade. Be very careful, as Wind Wall will block Disintegrate easily, so use of the 3rd Strike is suggested to catch him by surprise. Don't get too close, since he can dash in on you with Sweeping Blade and lay into you with auto attacks and Steel Tempest, then dash back out. It's fairly painful. Use your range to your advantage and try to shut him down early. You'll win easily once you hit 6 and can use Summon: Tibbers.
: This guy can be tricky. Early Seeker's Armguard is your friend. His Razor Shuriken moves fairly quick, so it can be difficult to dodge without at least Boots of Speed. Watch for use of his Living Shadow as well, for he'll combo that with Razor Shuriken and Shadow Slash to harass you. When his abilities are on cooldown, that's your opportunity to trade. Harass him with auto attacks when you can, but watch those Razor Shuriken. If he continues to use Living Shadow aggressively, call your jungler for an easy gank. His Death Mark can be used to avoid your stun, so you'll need to either use it after he ults, or catch him by surprise, or he'll burst you down.
: This guy is annoying, but that's about it. He'll be able to poke you from a safer distance with his Bouncing Bomb, so use the moments when he tries to farm to be aggressive yourself. He's more likely to throw his bombs where you're going, so constantly move side to side and be on alert so you can juke quickly. You'll be able to out burst him at level 6, so long as you haven't let him poke you down.
Getting harder... Level 4
: This foxy lady can outplay quite easily if you aren't careful. The number one thing you need to avoid is the Charm. If that hits you, you'll take heavy damage, or worse. Get tier 2 boots early so you can avoid her onslaught of Orb of Deceptions and Charms. Once her abilities are on cooldown, that's your chance to trade. Catch her by surprise with your stun when you hit level 6, so she can't Spirit Rush to safety.
: Man I hate her. If you try to poke her with your Disintegrate stun combo, she'll just use her Valor to dash away and soak the damage. Chances are she'll use Valor any time you use Disintegrate, so it'll be difficult to land a competent stun. Try your hardest to harass her with auto attacks before she hits a point where she has her Hexdrinker and can all-in you. If you can bait her Valor, that's your opportunity to truly bully her. NEVER stay and fight her when she has her Blade of the Exile active. Once she gets going, she'll annihilate you, so try your hardest to shut her down. Ask for ganks if need be.
: Oh boy, he can be one real doozy if you let him have his way. Harass him as much as you can as early as you can. If you let him harass you in return, though, you'll be in for a world of hurt. Once he has his catalyst the protector, don't expect to have an easy time killing him alone. Call for ganks early if you feel you need it, and shut him down so you have enough of a lead to massacre him. Otherwise it'll be a seriously crows call. HUEHUE
: She can be a real handful if not handled properly. Her Noxious Blast sets up her Twin Fang, so if you get hit and don't have a stun, expect a beating. She'll be constantly trying to harass you, so get early Boots of Speed so you can dodge her Noxious Blasts easier. If you happen to dodge it, that's your chance to throw an auto or two, or trade with your stun. Use your stun defensively if she hits you though. Both of you have devastating stuns level 6, so be very careful engaging onto her by making sure you have the advantage. She's a fairly easy gank target, so clear her wards and ask for help if needed. If you time your trades right and dodge her skill shot, you can win fairly easily, but that's easier said than done.
: His passive Void Stone is a natural counter to all AP mids. On top of that, his Null Sphere gives him a shield that blocks magic damage. Timing when to trade with your stun is very difficult, since he'll simply Null Sphere to take less damage. If he's playing aggressively, use your stun after he's Null Sphereed. Auto attacks are your best friend, so use them constantly. His level 6 will allow him to jump on you, and chances are, he'll win. Try to get an early lead so you can win fights. You'll be more useful in the long run.
: This guy can out stun you if you aren't cautious. If you walk straight at him in an attempt to stun him, he'll wreck you quickly with his combo of Event Horizon - Dark Matter - Primordial Burst - Baleful Strike. Use your auto attacks to harass him, since his priority will be farming up his Baleful Strike. Trade before he gets his ult. If he ever stuns you or his stun is on cooldown, don't hesitate to use your stun to trade. Once you hit 6, your best bet is to get the jump on him with Flash or when his Event Horizon is on cooldown.
: This guy can be tricky if you don't play cautiously. His Call of the Void has a fairly long range, and will silence you long enough for him to set up the rest of his combo without you ever stunning him. Watch how his Malefic Visions moves around your minions to avoid it. If you're running at him, he'll use Call of the Void in front of you. If not, he'll use it behind you or in front of you based on if you're on the defensive or not. Once you dodge it, you'll have an easy time trading with him. Get the jump on him to win once you hit level 6, so he doesn't even get a chance to ult you.
: If she could still silence, I'd have her as top tier threat in a heartbeat. Her poke combining Sigil of Malice and Distortion can be pretty devastating, however don't let it trip you up. Harass her with your auto attacks and bully with your stun if you can. You should trade fairly evenly, so long as you trade back against her harass. Watch for when she jumps past your minion wave, for that's when she'll try to use her Ethereal Chains. When you're ready to kill her, start with Disintegrate into your Ignite, followed by Summon: Tibbers and Incinerate. You won't be able to hit her with Disintegrate or Ignite once her mirror image takes effect, and she'll be likely to escape alive with a double Distortion.
The true terrors... Level 5
: Annie's ultimate counter. Her Black Shield will always nullify your stun effect, and basically nullify the majority of damage you would've dealt as well. If you ever successfully bait her Black Shield, that's your chance to poke with your stun. Use auto attacks frequently. Hide behind your minion line to avoid her Dark Binding. Even if you're in your minion line, she might still try to poke with her Tormented Soil. Her level 6 also gives her a strong stun against you and in teamfights. Fortunately, Morgana mid isn't a common thing, so don't expect to go against it often. Even if you do, request ganks. She can be double teamed easily pre 6.
: She's a mean mofo. Her poke has longer range than yours, her stun has longer range than yours, she can kite you if you walk at her, and she can burst just as quickly as you. Rush Sorcerer's Shoes so you can dodge her Dark Spheres. If she blows her Force of Will and Scatter the Weak meaninglessly, that's an easy chance to bully her. Focus primarily on dodging her abilities, and poke her back when they're on cooldown or when she's oom. If you can get the jump on her level 6, you can burst her much faster than she can burst you. Similar to Annie though, she has a huge weakness in her mobility. Catch her out with help from your jungler if you need assistance.
If there's someone I'm missing or someone you're curious about... lemme know.
Mid Game: What do I do now?
So you've won your lane and you got your turret. What use is Annie now? Well, Annie happens to be one of the best team players in the game! Use your utility to snowball around the map and help your team grab towers. Her use extends beyond a strong laning phase. Make sure you have vision control in areas that are hotly contested, and always be ready to participate in contesting dragon. You hit your biggest spike around mid game, so roam around and spread the love. I promise your CC will be welcome in any struggling lane. Gank bottom lane with a Summon: Tibbers stun, and use Tibbers to push the lane. Boom, you can get like 2 turrets off of that. Summon: Tibbers can also be used for a fairly early baron.
What's that? You LOST mid lane?? As surprising as that is, it's not entirely impossible. Annie won't have as much burst, but she makes up for it in utility. Follow the enemy mid laner and set up stuns in other lanes when you can. Winning fights for others is a great way to catch up yourself.
Late Game: NOW WHAT??
This is the weirdest part of playing Annie mid. I don't normally get to this point, but your primary use is going to be the CC from your stun. Use it to either engage, counter engage, peel, or follow up on an engage from an ally. Use your Disintegrate on the highest priority target, either being the APC or ADC. Hopefully that'll be enough to kill them. Your strength will not only be in team fights, but in picks as well. Don't be afraid to use your stun on a Disintegrate to catch someone on the enemy team out of position. However, make sure you know where the rest of the enemy team is, so they don't follow up. Blowing your stun like that can cost you the game. Remember that Annie is also very strong not only securing objectives, but contesting objectives. Don't be afraid to use Summon: Tibbers only to tank turrets or baron if you don't need the stun any time soon.
This ended up way longer than I had intended... oops. I know I'm not the best player in the world, or even the foremost Annie mid expert out there, but I hope some insight as to how I play Annie and How I played her at my lower levels will give all of you who are struggling out there some new options to try in your ranked play. Her strong laning and even stronger team fights can help anyone out :D So give it a try! I don't think you'll be disappointed.


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nerf guns
Sunday, March 4, 2007 - 22:17
are these difficult to connect with?
Copy_CanMar 04, 2007 - 23:26
Where are you getting your statistics from?
This is what I'd do: Print out your ads, place them on the wall, stand back, and ask yourself this question:
Do you think others will look at this ad and say "Damn, I wish I thought of that?!"
Having said that, I'd throw these ads right out of your book. Sorry.


text:
Agency toys with role for OPRA in corporate ratings
Site-level performance data compiled by the Environment Agency could help improve the robustness of assessments made by corporate rating agencies in the investment community, according to a new report.1 The report also highlights the wide variation in approach taken by rating agencies, and calls for more transparent methodologies.
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text:
特別授業3SLG THE ANIMATION (Tokubetsu Jugyou 3 SLG The Animation) were Based on a game by Bishop.
Ishizuka Kengo has started working as a teacher at the school he graduated from and has been given the job of taking care of the old school building until it gets demolished. While for others that task may have been troublesome for him it is an opportunity to satisfy his dark desires, and he wastes no time doing so…
Ishizuka's first target is Morimiya Saki, a student at the school, but soon he also targets Saki's friend Arisa, Saki's mother Rie, and another teacher at the school – Mashima Mikako. What awaits these four at the hands of the sadistic teacher?
Title: 特別授業3SLG THE ANIMATION
Romanji: Tokubetsu Jugyou 3 SLG The Animation
Brand: Hills
sex, nudity, torture, BDSM, bondage, rape, large breasts, female student, erotic game, school life, high school
Release Date:
2014/01/03 till 2014/07/04
Episodes: 2/2
Subtitles: No
Censored: Yes
Format: MP4
Add BDrip


text:
Three South Africans were among 32 people killed when a UN plane crashed in the Democratic Republic of Congo capital, the foreign minister said Tuesday.
"I can confirm that there were three South Africans aboard. We are saddened by what happened to these people on their noble mission," said Maite Nkoana-Mashabane of Monday's crash.
The Fokker 100 plane, run by the UN mission in DR Congo, smashed to pieces when it hit the ground as the pilot tried to land in torrential rain in Kinshasa, witnesses said.
It was carrying 29 passengers -- mainly UN officials and peacekeepers -- and four crew on a regular flight from the northeastern city of Kisangani to Kinshasa's N'Djili airport, according to the United Nations.
One person survived the crash, which is described as one of the worst disasters ever involving UN transport.
UN peacekeeping chief Alain Le Roy told reporters that "probably due to the wind, the aircraft missed the runway" and slammed into the ground.


text:
Medical Assisting is a career filled with countless possibilities for those interested in healthcare. Most Medical Assistants can be found in physicians' offices, nursing homes, and hospitals.
A quick look at the field shows that Medical Assistants are often hired as full time employees. While "duties vary with the location, specialty, and size of the practice," according to the Bureau of Labor Statistics (BLS), tasks commonly assigned to the Medical Assistant include
- Conducting patient intake
- Measuring vital signs (such as temperature and blood pressure)
- Logging vital statistics
- Assisting physicians with patient examinations
- Preparing exam rooms
- Cleaning and sterilizing medical equipment
- Administering injections
- Performing venipuncture and other routine testing procedures
- Scheduling patient appointments
The Medical Assistant in the Physician's Office
According to the Bureau of Labor Statistics, more than 59 percent of all active Medical Assistants today are working in the offices of physicians. Working in an office setting usually provides the employee with predictable hours, often between the times of 8 a.m. and 6 p.m., Monday through Friday. (Times and days will vary, based on a specific office schedule. Ask these questions when applying for a position to make sure the office hours fit your needs.)
Median pay scale for physician office-based Medical Assistants is $30,830, according to the BLS.
Finding Employment in a Hospital Setting
While the majority of Medical Assistants find work in an office, many other Medical Assistants find themselves working in state, local or private hospitals (up to 15 percent of the working Medical Assistant population). Hospital professionals can earn a median rate of $31,410, and may find the working hours much less predictable than those of their colleagues in the physician's office. For these professionals, "some work evenings, weekends, or holidays to cover shifts in medical facilities that are opened," according to the BLS.
Outpatient Care and Other Facilities
Other options for the working Medical Assistant are a variety of outpatient care centers, where up to 7 percent of these individuals find employment. Median pay here is $32,060, and hours will vary depending on the duties and positions available. Additional healthcare facilities and healthcare practitioners – non specified by the BLS, employ up to 10 percent of the remaining individuals in this field. Median pay rates fall a bit for these individuals, down to $27,980.
A Growing Field For Career Seekers
Medical Assistant is identified as a very stable field by the BLS, with the "employment of medical assistants projected to grow 23% from 2014 to 2024, much faster than the average for all occupations."
In a future blog, The Knowledge Nook will explore career growth opportunities for the working Medical Assistant, as well as valuable certifications that can boost your career.
Interested in the career of the Medical Assistant? Learn more by visiting PDI's new Medical Assistant program at certificate.pdi.org.


text:
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