text: Vertical Tabs Story Oct 07 2016 Montreal passed a new law on September 27 that has some dog-lovers barking mad. It's a ban on pit bulls. What's a pit bull? It's a name given to a group of bull terrier breeds. These dogs share certain characteristics. They usually have a squared head, powerful body, short coat and folded ears. ...How to Subscribe Currents4Kids is published 38 times per year (once per week except over Christmas and Spring Break) from mid-August until mid-June. A subscription costs $190 and may be used by all teachers and students within one school. To order, visit our order page, contact us by phone, fax, or email, or download and send in an order form. Thank you for your interest.


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text:
The Federal Government says it is seeking about $400 million World Bank loan to rebuild the North-east of the country, where Boko Haram terrorists had destroyed many of its infrastructure and social system.
Chairman of the Presidential Committee on North-East Initiative (PCNI), Lt. Gen. Theophilus Danjuma (Rtd), stated this during a visit by the Security and Peace Building Sub-Committee of the PCNI to the service chiefs in Abuja on Tuesday.
Also See: Army Recovers Another Missing Chibok Girl With 6- Month-Old Baby
Lt. Gen. Danjuma who was represented by the Deputy Chairman of the committee, Alhaji Tijani Tumsah, said the Federal Government was committed to kick-starting the robust rebuilding of the North-East in order to bring normalcy to the troubled region.
"The Federal Government is seeking a World Bank loan to rebuild the North-East. These figures will reach up to $400 million.
"And so we seek collaboration with the Nigerian Air Force (NAF) in a lot of ways, some of the areas, including using your experiences to curb violent extremism, disarmament, mobilisation, construction and renovation of schools," he said.
North East Nigeria have been ravaged by the Boko Haram insurgents who have destroyed lives, properties and rendered many homeless.
The Nigerian Army recently issued a security warning to Nigerians, disclosing a new strategy employed by the extremists in carrying out their attacks. According to the statement signed by the Deputy Director Army Public Relations, Colonel Mustapha Anka, the terrorists send suicide bombers to knock on houses, and when answered, they detonate their explosive vests.
Also See: Boko Haram Bomb Producer From Sambisa Arrested In Ibadan; Says Others Are In Lagos
He, therefore, warned the general public to be cautious and wary of strange persons knocking on their doors as it may be the remnants of Boko Haram insurgents scheme to unleash terror on their unsuspecting victims.


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Udupi: "I have not committed any sin, but have consented to the request of party workers to contest for the MLC polls," said Pratapchandra Shetty, sitting MLC and Congress party candidate for the upcoming MLC polls. He was addressing media persons at the Press Club, here on December 8.
"I had announced of not contesting the elections in a farewell programme and on other occasions. Party workers insisted me to contest for the MLC polls and had also staged a protest in front of my house. I was in a dilemma and soon I interacted with Rajya Sabha MP Oscar Feranandes and Chief Minister Siddaramaiah. The party has given me the ticket for contesting in the MLC elections and with the support of the party workers and the people, I am confident of winning the elections."
While asked about the dissent in the party over giving him the ticket for MLC elections, he said that everyone has the right to speak. "The efforts made to strengthen the local authorities are known to the people and party workers. The dissent will be settled when the party leaders will intervene," he added.
Gopal Poojary, MLA Byndoor Constituency and President of District Congress Committee, said that Jayaprakash Hegde and Bhujanga Shetty both were present in the party meeting where the decision was taken to re-elect Pratapchandra Shetty. "I have confidence that Jayaprakash Hegde and Bhujanga Shetty will support us and they will withdraw their nominations. When asked if the party would initiate disciplinary action if they continued to contest in the polls, he replied, "It is left to the KPCC to decide."
Pramod Madhwaraj said that Oscar Fernandes has presented his consultations with the district Congress, ministers and elected representatives to AICC and the AICC has accordingly given the ticket to Pratapchandra Shetty.
Vinay Kumar Sorake, Minister for Urban Development and Minister in charge of district, said that the differences regarding MLC elections will be settled as the Chief Minister and party high command has intervened.


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This is Part 2 of a 5-part series: Monetizing Your Podcast.
Previously we spoke about donations and subscriptions as tools to monetize your podcast. Today I want to touch on two concepts that can be both lucrative and easy to initiate: PPC (pay-per-click) and Affiliate Advertising.
In a nutshell, PPC advertising is a model that allows you, the site owner, to be paid whenever someone clicks on an ad hosted on your site.
There are a number of PPC models out there but the 800 lb. gorilla is Google AdSense. Once you've set up your account and installed the piece of code provided, Google displays targeted advertisements on your site. Each month you'll receive a check/direct deposit to your account for the clicks you got during the previous month.
Sounds good on paper and a number of people have been known to make upwards of five figures a month with AdSense. But, not so much anymore.
You can somewhat adjust the parameters of what type of ads can be displayed but you need to understand that you'll probably be displaying competitors ads.
Another drawback is that when someone clicks on an AdSense ad they're taken off of your site.
A big complaint about AdSense is the "cheapness factor" it portrays on your site. So many people have run into ad farm sites that are littered with AdSense and display ads that they automatically become blind to AdSense ads.
Many bloggers have since stopped or refused to start running Google ads because of the stigma associated with it. As well, the lower payments haven't been much of an incentive either.
Top PPC Ad Networks
- Google AdSense
- MS Adcenter (this includes Bing and Yahoo!)
- adBrite
- Miva
- Pulse 360
Affiliate Advertising
A more lucrative alternative to Pay-per-click is Affiliate Advertising. Like PPC you'll be running ads on your site for advertisers. Unlike PPC, you can either receive a commission on leads generated or sales made.
Some of the highlights of Affiliate Advertising
- You also can pick and choose the advertisers you want to appear on your site.
- Advertisers can easily be found with Affiliate networks.
- Commissions are much greater than that of PPC.
- You can choose where and how you want the ads to run on your site.
- With a bit of code, clicking on the ad opens a new window and doesn't remove the viewer from your site.
The ads you see on the right side of this page are all affiliate ads.
Some of the top Affiliate Networks include:
Website Magazines online addition has an excellent article of the Top 100 Advertising and Affiliate Networks to Consider in 2011.
One caveat to take into consideration with both of these plans is that you need site traffic to make them worthwhile. And, especially in the case of PPC, it's a numbers game – the more people that visit your site, the more opportunity there is for someone to click on an ad.
Blogs in general have had great success with both of these methods whereas podcasts are a special breed – due to the fact that your show is usually downloaded automatically to a listeners podcatcher and they have no need to visit your site on a regular basis.
You Need to Drive Traffic to Your Site
Probably the simplest solution to keep a continual flow of traffic to your site is to create a combination podcast/blog. I know, right now you're saying, "…but I spend a big chunk of my time creating the podcast! How am I supposed to keep a blog up as well?"
You don't need to blog everyday. In fact, two to three times a week would be just fine. So, what do you write about – sum up sections of your previous show.
- Talk a little bit about what you've just talked about.
- Go into detail that you may have missed during the show.
- Answer questions that may have arose after the show.
Take a look at my earlier post, 8 Ways to Market Your Podcast. The ideas there translate to marketing a blog as well.
Who have I missed that you've had good luck with?
Back to Donations and Subscriptions | Continue to On-Site and In-Show Advertising


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Background: Chromosome 22q11 deletion syndrome (22q11DS) increases the risk of development of schizophrenia more than 10 times compared with that of the general population, indicating that haploinsufficiency of a subset of the more than 20 genes contained in the 22q11DS region could increase the risk of schizophrenia. In the present study, we screened for genes located in the 22q11DS region that are expressed at lower levels in postmortem prefrontal cortex of patients with schizophrenia than in those of controls. Methods: Gene expression was screened by Illumina Human-6 Expression BeadChip arrays and confirmed by real-time reverse transcription-polymerase chain reaction assays and Western blot analysis. Results: Expression of GNB1L was lower in patients with schizophrenia than in control subjects in both Australian (10 schizophrenia cases and 10 controls) and Japanese (43 schizophrenia cases and 11 controls) brain samples. TBX1 could not be evaluated due to its low expression levels. Expression levels of the other genes were not significantly lower in patients with schizophrenia than in control subjects. Association analysis of tag single-nucleotide polymorphisms in the GNB1L gene region did not confirm excess homozygosity in 1918 Japanese schizophrenia cases and 1909 Japanese controls. Haloperidol treatment for 50 weeks increased Gnb1l gene expression in prefrontal cortex of mice. Conclusions: Taken together with the impaired prepulse inhibition observed in heterozygous Gnb1l knockout mice reported by the previous study, the present findings support assertions that GNB1L is one of the genes in the 22q11DS region responsible for increasing the risk of schizophrenia.
Schizophrenia, a devastating mental disorder that affects approximately 1% of the world's population, is a genetically complex disorder. The multifactorial polygenic model has received the most support as the mode of inheritance that underlies the familial distribution of schizophrenia; therefore, a variety of genetic, environmental, and stochastic factors are likely involved in the etiology. However, it is also possible that specific genes play major roles in susceptibility to schizophrenia. Genes involved in 22q11.2 deletion syndrome (22q11DS) substantially increases susceptibility to schizophrenia. 22q11DS is associated with several diagnostic labels including DiGeorge syndrome, velocardiofacial (or Shprintzen) syndrome (VCFS), conotruncal anomaly face, Cayler syndrome, and Opitz GBBB syndrome. Schizophrenia is a late manifestation in approximately 30% of 22q11DS cases, which is comparable to the risk to offspring of 2 parents with schizophrenia. The 22q11 deletion is detected relatively frequently in patients with schizophrenia; a number of studies have shown that 22q11DS schizophrenia is a true genetic subtype of schizophrenia1,2.
Although the deleted region is approximately 3 Mbp in most patients with 22q11DS, the critical region is approximately 1.5 Mbp.3,4 Less than 30 genes are located in the 22q11DS region. Studies of 22q11DS patients without the common chromosomal deletion suggested that the TBX1 is a major contributor to the conotruncal malformations of 22q11DS.5 One of the mutations in the TBX1 was found to be a loss-of-function mutation.6 Mice heterozygous for a null mutation in Tbx1 develop conotruncal defects.7 Deletion of one copy of the Tbx1 affects the development of the fourth pharyngeal arch arteries, whereas the homozygous mutation severely disrupts the pharyngeal arch artery system.8 The contribution of the TBX1 haploinsufficiency to psychiatric disease was suggested by the identification of a family with VCFS in a mother and her 2 sons. These 3 patients all had a null mutation of the TBX1, and one of the sons was diagnosed with Asperger syndrome after psychiatric assessment.9
Contribution of genes in the 22q11DS region to susceptibility to schizophrenia has been examined mainly by genetic association studies. Associations between schizophrenia and nucleotide variations in the ZNF74,10 DGCR, 11 DGCR14,12 PRODH,13 ZDHHC8,14 COMT,15–18 and CLDN519,20 genes have been reported. These associations, however, have not been confirmed in other populations19–22 or by meta-analyses.19–24
Studies of genetically engineered mice have provided supporting evidence for roles of the genes located in the human 22q11DS region in schizophrenia. Prodh knockout mice exhibited deficits in learning and responses to psychomimetic drugs.25 Observation of overlapping loci across 5 heterozygous mice strains with different deletion sites revealed that a 300-kb locus, which contains the Gnb1l, Tbx1, Gp1bb, and Sept5 genes, is crucial for impaired sensorimotor gating measured by prepulse inhibition test (PPI).9 In that study, the authors speculated that the GP1BB was unlikely to be related to schizophrenia because it is expressed only in platelets. The GP1BB causes Bernard-Soulier disease, which has no associated psychiatric disorders. The Sept5 heterozygous knockout mice did not show impaired PPI. Gnb1l or Tbx1 heterozygous knockout mice showed reduced PPI.9 Therefore, the authors concluded that the Tbx1 and Gnb1l are strong candidates for psychiatric disease in patients with 22q11DS.9 In another study, however, Tbx1 heterozygous knockout mice showed normal locomotor activity, habituation, nesting, and locomotor responses to amphetamine.25
Recently, Williams et al26 reported associations between polymorphisms in the GNB1L gene region and schizophrenia in the United Kingdom, German, and Bulgarian population. They found excess homozygosity at rs5746832 and rs2269726 in male schizophrenia subjects and that the markers associated with male schizophrenia were related with cis-acting changes in GNB1L expression. These mouse and human studies indicated a correlation between GNB1L gene expression and psychosis.
The working hypothesis of the present study was that genes in the 22q11DS region involved in the susceptibility to schizophrenia were likely to be expressed at lower levels in patients with schizophrenia than in control subjects. We performed a scan of expressional changes of the genes in the 22q11DS region in schizophrenic and control prefrontal cortex and found that the GNB1L gene was compatible with our hypothesis.
Brain specimens were from individuals of European descent Australian and Japanese. Australian sample comprised 10 schizophrenic patients and 10 age- and gender-matched controls (Supplementary Table S1). The diagnosis of schizophrenia was made according to the Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV criteria (American Psychiatric Association 1994) by a psychiatrist and a senior psychologist. Control subjects had no known history of psychiatric illness. Tissue blocks were cut from gray matter in an area of the prefrontal cortex referred to as Brodmann's area 9 (BA9). Japanese samples of BA9 gray matter from Japanese brain specimens consisted of 6 schizophrenic patients and 11 age- and gender-matched controls (Supplementary Table S1). In addition, postmortem brains of 37 deceased Japanese patients with schizophrenia were also analyzed (Supplementary Table S1). The Japanese subjects met the DSM-III-R criteria for schizophrenia. The study was approved by the Ethics Committees of Central Sydney Area Health Service, University of Sydney, Niigata University, University of Tsukuba, Tokyo Metropolitan Matsuzawa Hospital, and Tokyo Institute of Psychiatry.
Total RNA was extracted from brain tissues with ISOGEN Reagent (Nippon Gene Co, Tokyo, Japan). The RNA quality was checked using a Nanodrop ND-1000 spectrophotometer (LMS, Tokyo, Japan) to have an OD 260/280 ratio of 1.8–2 and an OD 260/230 of 1.8 or greater. Microarrays were used to screen for differential gene expression between Australian schizophrenic patients and controls. In brief, 500 ng of total RNAs were reverse transcribed to synthesize first- and second-strand complementary DNA (cDNA), purified with spin columns, then in vitro transcripted to synthesize biotin-labeled complementary RNA (cRNA). A total of 1500 ng of biotin-labeled cRNA was hybridized on Sentrix® Human-6 Expression BeadChip (Illumina Inc., San Diego, CA) at 55°C for 18 h. The hybridized BeadChip was washed and labeled with streptavidin-Cy3, then scanned with an Illumina BeadStation 500 System (Illumina Inc). Scanned image was imported into BeadStudio (Illumina Inc) for analysis. Forty-six thousand transcripts can be analyzed by a single BeadChip.
Expression of the GSCL, HIRA, SEPT5, GNB1L, TBX1, and CDC45L genes was analyzed by TaqMan Real-time polymerase chain reaction (PCR) system (Applied Biosystems, Foster City, CA). From RNA, cDNA was synthesized with Revertra Ace (Toyobo, Tokyo, Japan) and oligo dT primer. Expression of these 6 genes was analyzed with an ABI PRISM 7900 HT Sequence Detection System (Applied Biosystems), with the TaqMan gene expression assays for GSCL (Hs00232019_m1), HIRA (Hs00983699_m1), SEPT5 (Hs00160237_m1), GNB1L (Hs00223722_m1), TBX1 (Hs00271949_m1), and CDC45L genes (Hs00185895_m1) and normalized to expression of Human GAPDH Control Reagents (Applied Biosystems). GNB1L expression was analyzed in Australian samples and replicated the analysis in Japanese subjects.
Protein was extracted from prefrontal cortex tissues with Laemmli Buffer. Western blotting method was used to compare GNB1L protein levels between schizophrenics and controls. Each of 2 μg protein was run on Pro-Pure™ SPRINT NEXT GEL (Amresco, Solon, OH) and transferrd to BioTrace™ PVDF (Nihon Pall Ltd, Tokyo, Japan). Polyclonal antibodies against the human GNB1L protein (OTTHUMP00000028644) were generated by injecting rabbits with the following peptide: CAGSKDQRISLWSLYPRA (MBL, Nagoya, Japan). Mouse polyclonal antibody against beta-actin (Sigma Aldrich Japan, Tokyo, Japan) was also used for normalization purpose. The bound primary antibodies were detected with goat anti-rabbit or anti-mouse IgG antibody HRP conjugate (MBL) and Immobilon™ Western, Chemiluminescent HRP Substrate (Millipore, Billerica, MA) on X-film (Fujifilm Medical, Tokyo, Japan). The signals of GNB1L or beta-actin of each subject on X-films were quantitated by computer software, ImageJ 1.40g (http://rsb.info.nih.gov/ij/), and GNB1L protein levels were normalized to beta-actin and compared.
The subjects comprised 1918 unrelated Japanese patients with schizophrenia (1055 men, 863 women; mean age ± standard deviation [SD], 48.9 ± 14.5 years) diagnosed according to DSM-IV with consensus from at least 2 experienced psychiatrists and 1909 mentally healthy unrelated Japanese control subjects (1012 men, 893 women; mean age ± SD, 49.0 ± 14.3 years) of whom the first- and second-degree relatives were free of psychosis as self-reported by the subjects. The association analysis was approved by the Ethics Committees of the University of Tsukuba, Niigata University, Fujita Health University, Nagoya University, Okayama University, and Teikyo University, National Center of Neurology and Psychiatry, University of Tokyo, and all participants provided written informed consent. DNAs were extracted from these blood samples and the same brain tissues used for gene expression analysis. The tag single-nucleotide polymorphisms (SNPs) comprising rs5746832, rs5746834, rs2269726, rs748806, rs29807124, rs5993835, rs13057609, rs4819523, rs2073765, rs7286924, rs10372, rs3788304, and rs11704083 at the GNB1L gene region were selected by Haploview program using HapMap Project Japanese data set (http://www.hapmap.org/), as the previously reported schizophrenia-associated SNPs, rs5746832 and rs2269726, were forced included. The TaqMan reaction was performed in a final volume of 3 μl consisting of 2.5 ng genomic DNA and Universal Master Mix (EUROGENTEC, Seraing, Belgium), and genotying was performed with an ABI PRISM 7900HT Sequence Detection System (Applied Biosystems).
Genotyping quality control consisted of ≥98% successful calls. We confirmed concordance among repeat genotyping in ≈10% of genotypes.
The correlations between GNB1L expression and 13 SNPs, rs5746832, rs5746834, rs2269726, rs748806, rs29807124, rs5993835, rs13057609, rs4819523, rs2073765, rs7286924, rs10372, rs3788304, and rs11704083, were examined in Australian and Japanese brain tissues, respectively.
Mice treated with haloperidol were studied to examine the effects of antipsychotic treatments on Gnb1l gene expression. Thirty-nine C57/BJ6 male mice (age, 8 weeks; weight, 20–25 g) were housed under 10 h/14 h light/dark conditions with normal food and water ad libitum, where groups of 5 or 6 mice were housed separately, and 0.5 mg/kg haloperidol or saline was injected intraperitoneally once each day for 4 weeks or for 50 weeks. The dosage of haloperidol was at maximum clinically used, and 4 or 50 weeks for treatment term correspond to several years or half a lifetime in human terms, respectively. We used extreme but likely condition to clear up the effect of the medication. We determined the dosage of haloperidol according to the previous studies.27–31 Mice were sacrificed 4 h after the last injection to obtain brain tissues.
The prefrontal cortex was taken, and RNA was extracted with RNeasy kit (Qiagen, K.K., Tokyo, Japan). A cDNA was synthesized with Revertra Ace (Toyobo) and oligo dT primer. Expression of Gnb1l was analyzed by TaqMan real-time polymerase chain reaction (PCR) with an ABI PRISM 7900 HT Sequence Detection System (Applied Biosystems), with the TaqMan gene expression assay for Gnb1l (Mm00499153_m1). Expression of Gnb1l was normalized to that of rodent Gapdh with Rodent Gapdh Control Reagents (Applied Biosystems).
All animal procedures were performed according to protocols approved by the Animal Care and Use committee of University of Tsukuba.
Microarray analysis was performed with GeneSpring software version 7.3.1 (Silicon Genetics, Redwood, CA). The mean background noise level was first corrected in each sample, and then per-chip normalization was applied to eliminate systematic differences between chips. Two-tailed Student's t-test was used to examine the difference between schizophrenic patients and controls. In real-time PCR experiments, GAPDH or Gapdh was used as an internal control, and measurement of threshold cycle (Ct) was performed in triplicate. Data were collected and analyzed with Sequence Detector Software version 2.1 (Applied Biosystems) and the standard curve method. Relative gene expression was calculated as the ratio of expression of the target gene to the internal control (GAPDH or Gapdh). Correlations of GNB1L gene expressions and 2 quality parameters, postmortem interval (PMI) and pH, of brain samples were analyzed with analysis of variance (ANOVA) one-way tests by JMP computer software version 5.1. The density of images reflecting GNB1L protein levels was also compared between schizophrenics and controls with the Wilcoxon test implemented in JMP computer software version 5.1. Deviation from Hardy-Weinberg equilibrium (HWE), allelic associations, and linkage disequilibrium (LD) between SNPs were evaluated with Haploview software version 3.11. A nominal association was defined when the given P value for allelic or genotypic tests was less than 5% (uncorrected P < .05). If a nominal significant association was found in the analysis, permutation test was also performed with Haploview software version 3.11. Correlations of GNB1L gene expressions and either protein expression or genotypes of the tag SNPs were analyzed with ANOVA one-way tests by JMP computer software version 5.1.
Human-6 Expression BeadChip demonstrated that GSCL (GI_48885362-S) and TBX1 (GI_18104949-I) of 28 genes located in the 22q11DS region were expressed at lower levels in schizophrenic brains than in the control brains in the Australian samples (P < .05) (Supplementary Table S2). However, the signals of these transcripts were low, and reliable confidence was not obtained from any subject. Expression of CDC45L (GI_34335230-S) tended to be lower in schizophrenic brains than in control brains (P = .07). Data of GNB1L were not available in this platform (Supplementary Table S2).
We used real-time PCR experiments to evaluate expression of the 3 genes that were potentially underexpressed in schizophrenia prefrontal cortex by microarray and GNB1L, which was not assessed by the microarray in the Australian and Japanese brain samples. The difference in gene expression between the schizophrenia and control groups was not confirmed for CDC45L. In addition, because the reliability of HIRA and SEPT5 was not sufficient due to weakly expressed sequences in the array screening, we reexamined expression levels of these genes by real-time PCR method and did not find significant differences in gene expression between the schizophrenia and control groups. Expressions of TBX1 and GSCL were too low to obtain reliable signals with the TaqMan gene expression assay (Hs00271949_m1 and Hs00232019_m1, respectively). Relative expression of GNB1L was significantly lower in Australian schizophrenic prefrontal brains than in Australian control brains (average ratio = 0.57, P < .001) and in Japanese patients with schizophrenia than in control subjects (average ratio = 0.53, P < .0001) (figure 1A). No difference in GNB1L expression was observed between the Japanese and Australian schizophrenic patient groups (data not shown). GNB1L expression was not significantly correlated with pH of the brain tissue samples overall (figure 2), neither with gender (P = .62) nor PMI (F = 0.61, P = .44). Western blotting analysis also demonstrated the lower levels of GNB1L protein in brains of the schizophrenia sample than in those of the control sample from each ethnic group (approximate average ratio = 0.75, P = .027 in Australian sample and approximate average ratio = 0.69, P = .033 in Japanese sample) (figure 1B). There is a significant correlation between gene and protein expression observed in our samples (F = 4.7, P = .037).
There were no significant associations of tag SNPs at the GNB1L gene studied in the present study with schizophrenia in our Japanese case-control sample (table 1). Also no significant differences were found in distributions of homozygotes and heterozygotes between schizophrenics and controls (table 1). Williams et al26 reported male-specific associations of rs5746832 and rs2269726 with schizophrenia and correlation between those markers and the gene expression. However, such male-specific associations of rs5746832 and rs2269726 were not observed in our sample (table 1).
There was a nominally significant correlation between rs5748832 and GNB1L expressions in whole subjects (P = .014) and in Japanese (P = .028), but not in Australian (P = .66) (table 2). An allele of rs5748832 is correlated with high GNB1L expression in this study, while the previous study showed the opposite direction of correlation.26
Significant deviation from HWE in the genotypic distributions was observed at rs4819523 in the control group. Lower proportions of heterozygotes than those expected by HWE seemed to cause these deviations. Although genotype errors, chance findings, or actual structural variations in some subjects might have potentially caused these deviations, we could not determine which was most likely to cause these HWE deviations.
Gnb1l expression in mice was examined to exclude the possibility that reduced GNB1L expression was the effects of chronic treatment with antipsychotic drugs. The patients whose brains were examined in the present study had received long-term medication of typical antipsychotic drugs; therefore, we chose haloperidol as a representative antipsychotic drug. As a result, while Gnb1l gene expression in prefrontal cortex of mice treated with haloperidol for 4 weeks was not changed, the expression was higher in those treated with haloperidol for 50 weeks than in those with saline injected (P = .02) as shown in figure 3.
In the present study, we hypothesized that haploinsufficiency of some genes in the 22q11DS region might increase the susceptibility to schizophrenia not only in patients with 22q11DS but also in the those without 22q11DS and that such genes would be expressed at lower levels in the brains of schizophrenic patients than in control subjects. GNB1L appears to meet this hypothesis. Reduced GNB1L gene expression was detected in both mRNA and protein levels in Australian and Japanese subjects, suggesting that lower GNB1L gene expression produces lower GNB1L protein levels which underlie schizophrenia across ethnicities. Treatment of mice with haloperidol indicated that the reduction of GNB1L expression is not likely a consequence of antipsychotic medication treatment, though the possibility of reduction of GNB1L expression by other antipsychotic drugs remains. The present study did not provide evidence of whether TBX1 expression is altered significantly in schizophrenic brains because the signals detected by Illumina's Sentrix® Human-6 Expression BeadChip or TaqMan assay were very weak. Paylor et al9 mapped PPI deficits in a panel of mouse mutants and found that PPI was impaired by either haploinsufficiency of Tbx1 or Gnb1l. The present study of human brains confirms that GNB1L is an important candidate for susceptibility to schizophrenia.
There is little information about the function of GNB1L. GNB1L expression is relatively low in adult brain but is high in fetal brain. GNB1L encodes a guanine nucleotide–binding protein (G protein), beta polypeptide 1–like, which is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD) that may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. GNB1L contains 6 WD repeats.32 GNB1L shows homology to the human guanine nucleotide–binding protein β subunit (GNB1). GNB1 functions in G-protein–coupled receptor protein signaling pathways and intracellular signaling cascade.
Williams et al26 reported excess homozygosity at rs5746832 and rs2269726 in male schizophrenia subjects and that the markers associated with male schizophrenia were related with cis-acting changes in GNB1L expression. Firstly in the present study, we failed to confirm the association in our Japanese case-control population. Secondly, we found a nominally significant correlation between rs5746832 and GNB1L expression in the Japanese brain samples, but failed to find it in our limited number of the Australian samples. Further, the association between allele and gene expression in our Japanese samples was in the opposite direction from that reported in the Caucasian samples. It might be due to possible differences in LD block between haplotype phases across rs5746832 and harboring potential cis-acting variations of the gene between 2 ethnic populations. Even if such cis-acting variations are present, diagnosis has tremendous effect on the gene expression, in comparison to that of the SNP. The power of the present study to replicate the findings of excess homozygosity in male subjects is greater than 90% assuming the odd ratio of greater than 1.5 found in UK populations by Williams et al.26 However, if the odd ratio assumes 1.3 observed in a German population by them, the power drops to 0.65. Although the gene frequencies of rs5746832 and rs2269726 were significantly different between Caucasian and Japanese populations, the frequencies of homozygotes were almost the same between 2 populations. Because of small sample size, we did not attempt allele-specific expression analysis in our brain sample. Therefore, we could not conclude whether lower GNB1L gene/protein expression in schizophrenia was due to cis-acting differences by genetic polymorphisms in this locus or not in this study.
The present study showed that reduced expression of GNB1L may be involved in the pathophysiology of schizophrenia; however, it does not exclude the possibility that other genes in the 22q11DS region contribute to the susceptibility to schizophrenia. The array used in the present study did not examine all isoforms of the genes in the 22q11DS region. In addition, the reliability of weakly expressed sequences in the array screening is not sufficient. Therefore, we reexamined expression levels of the genes, which reliable data (greater than 0.96 confidence) was produced by the array in no subjects, by real-time PCR method. The study is also limited by the areas and ages of the brains examined. We examined only adult postmortem prefrontal cortex. Differential gene expression in other brain regions or during other developmental stages may also influence the susceptibility to schizophrenia.
The consortium data of the Stanley Medical Research Institute showed no significant differences (P > .05) in the following gene expression levels in postmortem prefrontal cortex between patients with schizophrenia and controls: DGCR6, PRODH, DGCR2, STK22B, DGCR14, CLTCL1, CLTCL1, HIRA, UFD1L, CDC45L, CLDN5, TBX1, FLJ21125, TXNRD2, COMT, ARVCF, DKFZp761P1121, DGCR8, HTF9C, RANBP1, and ZDHHC8. The expression of RTN4R might be potentially reduced (P = .02). No data were available for GSCL, MRPL40, SEPT5, GP1BB, and GNB1L (http://www.stanleyresearch.org/brain/menu.asp).
A trans-acting effect on expression of the disease gene may also be expected to modulate disease susceptibility. Large-scale studies in humans have indicated that a significant proportion of the heritable variance in gene expression is attributable to trans-acting polymorphism.33,34 As one of the examples, recent study reported that microRNAs regulate gene expression posttranscriptionally.35 Even for schizophrenia, Bray et al36 indicated that the reduction in DTNBP1 expression in schizophrenia is likely to result in part from trans-acting risk factors. Such trans-acting factors that regulate GNB1L gene expression, however, have not been identified.
In conclusion, the present study further supports the role of GNB1L in the pathophysiology of schizophrenia.
Supplementary tables are available at http://schizophreniabulletin.oxfordjournals.org/.
Grant-in-Aid for Scientific Research on Priority Areas; Research on Pathomechanisms of Brain Disorders from the Ministry of Education, Culture, Sports, Science and Technology of Japan (20390098 and 20023006); Japan Science and Technology.
Australian human brain tissues were received from the NSW Tissue Resource Centre, which is supported by The University of Sydney, Neuroscience Institute of Schizophrenia and Allied Disorders National Institute of Alcohol Abuse and Alcoholism and NSW Department of Health.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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text: At a news conference beginning at the National Press Club, the top two leaders representing public port authorities in the United States will respond to the Bush Administration's recommended appropriation levels for the Department of Homeland Security's Port Security Grant program and the portion of the U.S. Army Corps of Engineers' Civil Works program that provides crucial navigation access to ports. Representing the American Association of Port Authorities will be Kurt Nagle, president and CEO of the American Association of Port Authorities (AAPA), and Warren McCrimmon, president and CEO of Ohio's Toledo-Lucas County Port Authority, who also serves as AAPA's U.S. Delegation chairman. In its proposed fiscal 2008 budget, the Bush Administration recommends the Department of Homeland Security's Port Security Grant program—the only federal program that assists public ports to fund marine facility security improvements—receive $210 million in Congressional appropriations. This is the largest amount the President has ever recommended as a line item for this program and it is equal to what Congress appropriated in fiscal 2007. Still, it is in stark contrast to action taken last fall when Congress approved and the President signed into law the SAFE Port Act of 2006, authorizing $400 million a year in Port Security Grant program appropriations—the level that AAPA recommended. The Administration's budget request calls for an 8 percent overall increase in DHS's budget in fiscal 2008, but recommends no increase for port facility security. "The federal share of the seaport facility security funding partnership needs to be increased to the level the President and Congress approved in the SAFE Port Act," said AAPA's Mr. Nagle. Since its inception in 2002, the Port Security Grant program has provided much-needed help to address immediate security needs and assessments. But federal money allocated in the first six rounds of the program–about $876 million–accounted for only one-fifth of what seaports identified as needs. For more than four years, AAPA has urged the Administration and Congress to annually fund the program at the $400 million level. AAPA has also urged DHS to allow the grants to reimburse expenses such as security personnel and long-term security equipment maintenance. Although airports, first responders and research and development centers receive most of the federal attention and funding for security and terrorism prevention, seaports–which support 5 million jobs and annually handle $2 trillion worth of cargo and more than 9 million cruise ship passengers–remain largely under-funded at the federal level. As a result, they must divert limited port resources to pay for enhanced security, in some instances at the cost of improving their facilities to handle fast-growing trade volumes. According to Mr. Nagle, the Administration's budget request also seeks an insufficient amount to fund the Corps of Engineers' Civil Works program, which is vital to meet the navigation needs of America's seaports and the businesses they serve. Although $1.1 billion to $1.3 billion in funding from the Harbor Maintenance Trust Fund is needed to maintain federal navigation channels, the Administration's budget calls for only $735 million. U.S. port development and maintenance is a shared responsibility of federal, state and local governments, with extensive private sector participation. The federal government maintains harbor access channels, while individual ports spend more than $2.1 billion annually to construct and maintain the landside terminal facilities, dredge their own berths and contribute to channel improvement cost-sharing programs. Overall, the Administration is requesting $4.871 billion for the Corps' Civil Works program, compared to the $4.733 billion it requested last year, representing about a 3 percent increase. "We're pleased the President's budget request for the Corps' overall Civil Works program appropriation is about $141 million more than last year's request. If accepted, that would translate to $28 million more coming out of the Harbor Maintenance Trust Fund to pay for navigation channel maintenance," stated Mr. Nagle. "While we applaud any incremental increase in funding for this program, the President's proposed budget still falls far short of the more than $1 billion that is needed annually to maintain the nation's navigation channels at their required depths and widths. Proper funding would help reduce shipping costs for America's businesses, making the products we buy and sell less expensive." Mr. McCrimmon, AAPA's U.S. Delegation chairman, noted that it's particularly troubling that the Administration recommends short-changing navigation channel maintenance when the money to dredge the country's shipping lanes to their required levels has been "prepaid" by the users of those waterways via payment of a cargo tax on imports and domestic freight. He said AAPA will continue to work with the Administration and Congress this year and in future years "to help put the 'trust' back into the Harbor Maintenance Trust Fund" and to assure that federal appropriations for the Corps' Civil Works program are raised to meet the needs of businesses and the port industry. Nagle noted recent reports about a rise in U.S. exports as being "…good news for American businesses trying to compete in overseas markets." However, he said that this type of news would be much more common if the harbor maintenance taxes collected from U.S. importers and domestic shippers were used exclusively for their intended purpose, which is to maintain the country's shipping lanes at their authorized levels, thereby improving access and reducing transportation costs. Mr. Nagle added that the U.S. economy, environment and national defense depend largely on how well we can ensure deep-draft shipping access to our seaports and protect them against terrorism.


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The mission of the RESOURCE CONSERVATION DISTRICT OF THE SANTA MONICA MOUNTAINS is to promote land stewardship and resource conservation through ecological research, conservation planning and design, habitat restoration and environmental education, while adhering to the highest standards of transparency and accountability as a public agency. The District encompasses the Santa Monica Mountains from Point Mugu to Topanga State Park and includes the Simi Hills, Santa Catalina Island, Pierce College, Sepulveda Basin Wildlife Area and Chatsworth Reservoir. A map of the district can be found here: District Map
The District is governed by a board of five non-salaried directors appointed by the Los Angeles County Board of Supervisors. They are assisted by Associate Directors and Resource Associates: scientists, educators, and community leaders who have volunteered to assist the District in its work, serve on committees, represent the District on request of the Board, and participate in meetings. Board of Directors' meetings are public and can provide a forum for current conservation issues.
The District is financed through a minimal property assessment. Other revenues include grants from public agencies or private foundations, contracts for education, research, and restoration services, and from donations. All donations are tax-deductible.
The District works closely with the Natural Resources Conservation Service of the U.S. Department of Agriculture, the U.S. Environmental Protection Agency, National Park Service, California Department of Conservation, California State Parks, Los Angeles County and the Los Angeles Regional Water Quality Control Board to carry out the District's responsibilities for providing leadership to identify local resource conservation needs, advocate for effective solutions, and work with appropriate parties on implementation.
Professional educators are employed by the District to assist administrators and faculties of school districts to develop resource conservation curricula and to conduct education programs with schools, youth groups, non-profit organizations, and government agencies. Scientists and consultants are employed to enhance the District's role as a consulting agency to planners in other units of government and as a contractor for natural resource study and restoration projects. The District also employs a staff of administrative and clerical personnel.
Current services and projects of the Resource Conservation District of the Santa Monica Mountains include:
- Lead agency coordinating federally funded Malibu Creek Watershed Executive and Advisory Committee
- Watershed restoration
- Oak monitoring
- Wildlife inventory and biodiversity studies
- Sale of native and drought resistant plants for conservation purposes
- A tree registration program
- Natural science education field programs at Malibu Lagoon, Topanga State Park and Sepulveda Basin
- A research/reference conservation library.
A State of Harmony
If you have ever wondered what a Resource Conservation District or a Land Trust does, check out this video. "A State of Harmony" depicts the shared land ethic behind the important protection and stewardship work being done by RCDs and Land Trusts in California.


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Todos estamos invitados Trailer (2008)
11 April 2008 Drama, Thriller 80 mins
Spain. The Basque Country. Sometime in the 90s. Josu Jon, a young member of a terrorist organization, has suffered an almost complete memory loss after being wounded in a shooting with the Spanish police. As he awaits for his trial, his condition is being treated at the prison hospital. Other inmates belonging to the same organization try to make him remember how brave a "gudari" -a Basque soldier- he is and how he must go back to the armed fight for the independence of their country as soon as he gets out of prison. Meanwhile, Xabier, a college professor who has been death-threatened by the terrorists due to his political views on the Basque situation, is having an affair with Francesca, a young psychologist who happens to end up trying to help Josu Jon recover his memory. A warm feeling of mutual affection grows between her and her patient. At a point, it doesn't seem to be clear whether Josu Jon really wants to recover his memory or rather forget forever who he actually is.
Watch the official Todos estamos invitados 2008 trailer in HD below or find more Todos estamos invitados videos on Vidimovie.


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Natore is famous for "Kacha Golla", during my tour I have eaten as much as i could. Also the district has two rajbari, and both of them are mind blowing in terms of the design and architecture. Also the district holds the 1/3 part of the great Chalan Beel. This district has plenty of natural beauties to please your mind either.
Popular locations for visit:
If you are planning to visit the Natore district, you can check the "places of interest", or "must see", or "tourist spot" items from the link http://icwow.blogspot.com/search/label/natore. Also if you visited any other places from Natore, that is not listed at my link, that case you can add that here as comment.
Where to Stay:
There are few quality hotels at the Natore district. Hotel Millat, Hotel Roxana, and Hotel RP are excellent from them. I have stayed at Hotel RP, and it was an AC room, cost 500 taka per night.
Manager: Mr. Habib
Mobile: 01726-433428
Phone: 0771-62579
Hotel: Hotel RP
Address: Rais Plaza, Dhaka Road, Kanaikhali, Natore
How to reach:
There are several ways to reach at the Natore town. National Travels is the best available bus service for this district. Also you can take on Hanif or Shayamoly bus for the route. Also the Ekota Express, and other north Bengal trains are available for you.
For bus, you can book your ticket from Gabtoli bus terminal, or Kalyanpur bus terminal. It will take around 4-5 hours to reach at the Natore town from dhaka.


text:
Mauritius-islander.com ranks
#5,013,969 in the world and generates
425 Page views for daily.
FreeWebsiteReport estimates Mauritius-islander.com for a valuation of
$930 USD for it's visitor traffic that has the potential for CPC and Display-based advertising.
This traffic data suggests the Advertisers with a Traffic Acquisition Cost (TAC) of
$1.27 for daily and
$38.23 for monthly to spend on advertisements with Mauritius-islander.com. Mauritius-islander.com's page load time for
90th percentile measures at 17 sec. Mauritius-islander.com receives most of it's
organic referrals traffic from 25 websites around the world. Mauritius-islander.com servers are located in the Germany.
|Time Average
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3 Month
1 Month
Find out about the country and her people, flora and fauna, hotels and bungalows, history and society.
Travel and Tourism Travel Guides Maurice Voyages et tourisme Mauritius
Google Safe Browsing - Safe website. Clean from Viruses, Malicious Worms, Adwares, Trojans, Spywares and Suspicious Phishing Attacks.
|DMOZ Name
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Nagelshof 8, Hamburg, 22559, GERMANY. Phone: +49 40 810497, Fax: +49 7024 978150 Email: contact[AT]mauritius-islander.com


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Results 1 to 4 of 4
Thread: Help With Listbox
03-26-12, 11:06 #1Registered User
- Join Date
- Mar 2012
- Posts
- 5
Unanswered: Help With Listbox
Very confusing to try & explain which is possibly why i cant figure it out.. im open to any and all suggestions... I had assumed Listbox would be the only way. I am writing database for International Shipping Company.
I have multiple forms for entering the Shipper / Reciever / Tracking & booking Details for a shipment.. The table that data is stored in is ExpRecords & the Link i am using between all forms is my companies reference number "AEC".
During shipping process my company needs to setup multiple things per shipment..
1) Booking ( with actual booking & sailing information for air/ocean shipment)
2) Trucker Move Order ( Trucking loading the cargo date & time )
3) Dock Receipt ( Which is a form that is like a commercial invoice or bill of lading.)
Now... if we were to have a single shipment with TWO containers or TWO crates... There is possibility we would need to create TWO dock Receipts & two Trucker Move orders.. Thats where im stuck.. I could create one but not two.
I need the user to be able to make a selection of what he wants to create (Maybe a combo box ? BOOKING / MOVE ORDER/ DOCK RECEIPT) When the user selects that... It will need to OPEN the form i have made (ExpBooking,ExpMoveorder & ExpDockReceipt ) & pull in the information already entered elsewhere with some forms that need to be edited. The user would need to be able to access that record at later time.. So if i had for instance 5 cars to ship.. .I would need 5 seperate move orders & 5 seperate dock receipts. I am guessing i need another table for each type of item that can be added... Link them by AEC (my reference number) & then give them another ID to show they belong to that record?
I was thinking that a list box would properly display them like below.
(Combo Box )
''where user can select to make new Move order/ Booking / Dock receipt''
'' Where it displays what has been created, You can double click to open it & edit it. Below is example.. these lines would be click able - open the corresponding form & record.
Im Very confused... It seems to me like when you select a "New Item" you would assign it with current shipment reference but then also another ID because there is multiple records to every ONE shipment. Please help!!!
03-26-12, 14:16 #2Registered User
- Join Date
- May 2004
- Location
- New York State
- Posts
- 1,178
Instead of a listbox, I suggest you have another combobox, textbox, or MsgBox with a prompt asking "How many " <the document name here> "do you want to generate?" and allow the user to enter a number: 5 in your scenario. In the Update event (of the combo or text boxes) or after receiving the "Msg" from the MsgBox function, simply do a For Next loop opening the appropriate form (you already know which form it is, from the previous combobox), saving the record, closing the form, and re-opening until the loop is completed as many times as necessary.
03-26-12, 17:14 #3Registered User
- Join Date
- Feb 2012
- Posts
- 14
03-28-12, 13:47 #4Registered User
- Join Date
- Mar 2012
- Posts
- 5
This would be OUTbound shipping. The booking / dock receipt / move order are all child tables based off the main parent table ExpRecords.


text: Dawn By Elie Wiesel Dawn by Elie Wiesel Dawn by Elie Wiesel Chapter 1 Takes place in Palestine. The narrator knows that he has to kill a man tomorrow. He doesn't know who it is but he knows what he has to do. The man that was going to die was an Englishman. The reason that he had to kill was because there is a war. Beggar. A man that taught the narrator the difference between night and day. Narrator met him while he was at the synagogue. The man wears black clothes. The narrator met the man when he was 12 years old


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Molton Brown Relaxing Yuan Zhi Bath and Shower Gel
Extracts from the Chinese Yuan Zhi plant - calm and soothe. Use in the evening - at the end of a stressful day to promote a restful sleep! Smells grea...
6 reviews from the community
Review of "Molton Brown Relaxing Yuan Zhi Bath and Shower Gel"
Thank you for all the reads and rates!
"A little luxury from Molton Brown"
When I began writing this review, my first peice of research was to find our what yuan zhi is/means. Somethng deep and meaningful - surely? But according to google he's a Chinese volleyball player. Now I don't know if this bath and shower gel is named after him, but I'm guessing probably not.A little further research told me that yuan zhi is in fact a wild plant from South China that is used to balance energy and soothe the spirit. This gel also contains mango oil, which is an anti-oxidant skin conditioner, as well as rose and vanilla.
The gel can be used as a shower gel or bath foam, and is intended to help you destress and relax, and is good to use before bed to help you get a peaceful night's sleep.As with all Molton Brown products, this gel comes in lovely, expensive looking packaging - which it darn well should at £17 for a 300ml bottle! The bottle is see-through and the beautiful purple colour of the gel inside makes the product look even more luxurious. It is definitely a nice product to display in your bathroom.
I tried this out in the shower. The gel is extremely thick and very rich, and you really need very little. It lathers up nicely and feels luxurious on the body. It is a real pleasure to use, and the scent is quite exotic and musky - not like any other products I've used. I didn't detect the rose or vanilla in here, but there is a slight floral undertone to the fragrance, and it leaves skin smelling lovely and feeling soft and moisturised after use.Sadly the price of this product is off-putting, and I have to say it isn't something I would splash out on for myself - I was lucky enough to receive this as a gift. But you do need very little so I think it would last a lot longer than other, cheaper shower gels, so this could help justify the cost! I'm also really looking forward to trying this out in the bath as I think it will make a really luxurious bath soak.
Overall, a lovely, expensive looking and feeling product.
Summary: A lovely product if you can afford it!
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paulpry118 published 17/10/2010We had some complimentry Molton Brown toiletries on a recent hotel stop and to be honest I didn't rate any of them that much
hannahmc3 published 15/10/2010Great review!
daniella2010 published 14/10/2010I like Molten Brown but it is significantly over priced. I've not smelt this one before - nicely reviewed
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Product Information : Molton Brown Relaxing Yuan Zhi Bath and Shower Gel
Manufacturer's product descriptionExtracts from the Chinese Yuan Zhi plant - calm and soothe. Use in the evening - at the end of a stressful day to promote a restful sleep! Smells great. Contains Mango too!
Product Details
Long Name: Relaxing Yuan Zhi Bath and Shower Gel
Type: Shower & Bath
Genre: Shower Gel / Body Scrub
Manufacturer: Molton Brown
Listed on Ciao since: 03/12/2007


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Just like spring when baseball teams begin a new season with a fresh slate, the new year is the time to list our promises. Whether it's getting rid of old bad habits or starting a new chapter, our end game should be self-improvement.
In part, the practice of New Year's resolutions came from the Lenten sacrifices but regardless of creed, we can all reflect upon our weaknesses and resolve to be better.
Popular resolutions often involve our spiritual, physical or mental well-being but there is also room to improve our finances, career or in social interactions such as volunteering, or spending quality time with family.
The odds of following through on resolutions are stacked against us. One study involving 3,000 people by Richard Wiseman from the University of Bristol showed that 88 percent of those who set New Year resolutions fail.
There are some however, who do mean business, literally.
John Herod, who runs a Schlotzsky's Deli and Cinnabon in Abilene, Texas, made news last month when, in the midst of the holiday season, he posted a message on the marquee outside, alerting customers that the business was "Closed for Attitude Adjustment."
Herod felt his employees were not offering an acceptable level of customer service. There weren't a lot of smiles and the service was slower than what he felt his customers deserved.
Some workers were let go and those remained went through retraining on everything from cleaning to preparing the food. Herod explained he wanted each employee to have time to think about the job they were doing, and the service they were giving out.
Herod may have latched onto something with his self-improvement model. When children need correcting, parents order a "time out" for them to reflect. The adult version is called "attitude adjustment" and just like the children, there is no shortage of candidates.
By Jim Zbick


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Is Your Website Ready for Black Friday?
When running an e-commerce website, downtime is the equivalent of locking your doors to the public. Not only are you not doing business, but you're also actively pushing your customers into the arms of the competition. Amazon found that every 100 milliseconds of downtime cost them one percent in sales, and Google found that an extra .5 seconds in search page generation time dropped site traffic by 20 percent. Slow performance affects everything from individual transactions to customer retention, and ultimately revenue. E-commerce businesses simply cannot afford to suffer a slip in performance.
There are several failure points you have to research carefully to avoid, including having a good hosting provider and using a reliable content delivery network (CDN) to keep your traffic flowing. However, your website is your responsibility, and it's up to you to do the load testing and proactive monitoring required—seeing problems developing early and heading them off before they take you down.
Target, for example, greeted its Black Friday shoppers with a page reading, "So sorry, but high traffic is causing delays. If you wouldn't mind holding, we'll refresh automatically and get things going ASAP." With a stress test and a concurrency test, the site could have been exercised well before the busiest online shopping day of the year, and the bottlenecks and inefficiencies could have been eliminated.
Best Buy had their share of problems in 2014 when their website experienced problems through Black Friday and into the following Saturday. Instead of facilitating online business, their website failed because, according to a company statement, "BestBuy.com has experienced record levels of website traffic. This has affected site performance, and we have temporarily taken the site down in response. We are taking measures to restore full performance of the site as quickly as possible." They, too, could have avoided this with a scalability test that would have let them know well in advance when they would reach the breaking point of their website.
It's not just downtime that can torpedo an otherwise irresistible website. Below are five tips for e-commerce sites this holiday season.
Test All Device Types
This is a world full of different browsers and an assortment of mobile devices with different operating systems. Each needs to be catered to if a website is going to be successful. Most consumers expect the same quality and speed of performance when shopping on mobile devices as they do when shopping online. Creating a set of tests that emulate desktop devices and mobile devices along with tests that emulate all of the popular web browsers can ferret out problems that might not otherwise be found. Overlooking those tests might launch a website that works fine on an iPhone, but is terrible on a Galaxy S6. Chrome users may see a poorly-rendered page, while Firefox users are delighted with the site. Test against all device types and your site will be stable and well-rendered regardless of the device used to get there.
Load Test Your Website
Load testing is a way to control your website's performance during different types of load (traffic). Measure your e-commerce website's performance during normal variations of traffic. Test regularly before, during, and after peak season to make sure you have reliable information on your website's usual performance. Specialized companies can test and optimize your website, simulate peak loads by using synthetic traffic, and suggest improvements. These companies usually also offer cloud-based monitoring services.
Test Your Maximum Load Capacity
Without testing, it is nearly impossible to know what will happen at peak loads, like during the Christmas holiday. Scenarios that usually work flawlessly may become bottlenecks. Damage control is a test which shows what it will take to crash your website and how. With a damage control test, you can see how your website gets back on its feet—even at full load capacity. A specialized company can give you advice on how to avoid a website crash or slow response times when the number of visitors increases dramatically.
Optimize Images and Videos
It might feel cool and modern to have many high-resolution images and videos on your website, but it can have a bad impact on your response times. If you do want large images on your site, make sure to invest in a system that can do short response times despite high-resolution content. Use a so-called CDN/accelerator service in order to speed up the delivery of heavy content, such as images and videos.
Know Your Website Speed
Even during large loads of traffic, the time it takes for a visitor to download your entire website should not be more than three seconds. E-shoppers don't have much patience. If the website is too slow, the visitor will search for the same product on a different website. If your response time is too long, you will lose both conversion and Google ranking. We can all agree that the speed and quality of a website's performance affects consumer trust. Similarly, waiting more than a few seconds for a website to load will negatively affect your bottom line. Analyze how well your website holds up in comparison to your competitors: Are you faster or slower? How much money are you loosing because of bad response times and conversions?
E-commerce has become a key part of every business. Whether a business sells its goods or services over the internet or simply advertises there, having a website with spotty performance—or one that crashes due to overwhelming demand—will ensure loss of sales and prestige. Prestige can be recouped, but lost sales can never be regained. Website testing for flash crowds, sustained traffic, and various device types can help the knowledgeable merchant keep his web presence up and servicing his clientele.
Sven Hammar is co-founder and CEO of Apica, a provider of powerful, best-in-class technology for testing, monitoring, and optimizing the performance of cloud and mobile applications. Mr. Hammar he has decade-long experience and expertise in web performance and web optimization, e-commerce, cloud services, IT entrepreneurship and the Internet. He is also a serial entrepreneur who has founded several successful IT companies over the years. See http://www.apicasystem.com/.


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Each Thursday evening, one of SFMOMA's curators or specialists shares a perspective on a single artist or artwork on view. Talks last 20 minutes.
Corey Keller on Alfred Stieglitz's Georgia O'Keeffe — Hands and Thimble
Related Exhibition The Anniversary Show
Thursday, May 06, 2010, 6:30 p.m.
Meet in the Haas Atrium before moving into the galleries.
Corey Keller, associate curator of photography, SFMOMA
Additional Info
SFMOMA regrets that Corey Keller's talk has been cancelled due to unforeseen circumstances.
Image: Alfred Stieglitz, Georgia O'Keeffe--Hands and Thimble, 1919; palladium print; Collection SFMOMA, Purchase, Alfred Stieglitz Collection


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The Seven Book
£ 5.99
Who are the Seven and how can they help Tony find the little prisoner? How does Lucy Morgan become trapped in an old story with a load of cobwebby old men? How do you reform a school bully without intending to? What happened to Bryn the dog anyway ?
The Ravens Call Book
£ 20.00
In the midst of life we are in change. The one thing we can trust is that there will be change, and it may often be our ability to deal with it that defines us.
There is no secret system or ancient codebook which shows us how to deal with personal loss and challenging change - no 'quick fix' guide. All we have is our individual common sense and our instinct to survive.
The Song of Taliesin - Double CD CD
£ 12.00
Adapted and performed by Steve Gladwin, The Song of Taliesin by John Matthews, is a fantastic introduction to the Welsh Bard.
Wednesday 22th February 2017
The raven is very much a family bird and very loyal. The mother raven will meticulously clean any mess out of the nest which her chicks have dropped and fly some distance to deposit it in order to keep the nest clean. The male bird is no absent parent either.
If you want to find out a great deal more about either, I urge you to read any of Bernd Heinrich's wonderful books, particularly 'Mind of a Raven'. The 'Three Ravens' poem I wrote for The Raven's Call was partly inspired by Bernd Heinrich's work but also by both the scavenger and trickster images of raven. Whatever you may feel about Corvus Corax, one thing is undeniable and that is that he or she is a born opportunist, forever looking, as pulp detective writers used to say – for the main chance.
At this time of year, any raven with any sense is not just looking for the main chance but for anything which happens to come into land or cross his path. Sometimes these juicy bits can turn into quite unexpected jewels.
The Raven's Call first existed as a book dealing with loss and challenging change and using the natural cycle of the year to illustrate this. The book itself will shortly be reissued, but that's only the beginning. I have been counting the little chicks which our nurturing mother has given birth to and kept the nest clear of and at this moment in time there are already five.
First in June last year the book inspired the storytelling programme that I produced, based on several of the stories in the book. 'From Raven's Call to Swallows Flight' was first performed at Carrog Village Hall and included a unique opportunity to ask death questions. One of my favourites of these came from someone who was clearly a Terry Pratchett fan, because it was 'How's Susan?'
In September came the news that the overall premise would be used again in two further book collaborations with Slippery Jacks Press in the form of 'Swallow Tales'(for junior/primary) and 'Shape-shifters', (Secondary)
The end of November gave birth to probably the book's most important chick yet with the setting up of a workshop for Powys Mental Health Service staff and volunteers using the cycle of the year/cycle of recovery, used in the book. This work is on-going.
Next week I visit Welshpool High School to talk to staff about the school's involvement in 'Shape-shifter' and particularly in helping me to devise a workshops section for the book. There is also talk of similar work with Young Carers later on in the year,(two of the stories in the book concern a young carer) around the stories and themes.
So like both the meticulous mother and the risk taking father I can only watch in satisfaction while our chicks fledge and I wait in anticipation to see what delights they can bring back with from their travels in this world and beyond.
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text: Readable research. This distinctive, theory-driven text uses "The Self" as a theme to give students a meaningful context for exploring the key concepts of social psychology. "Applications" sections have been incorporated into most chapters, and "Featured Study" sections at the end of every chapter summarize the purpose, method, and results of recently published scientific articles. Retaining the emphasis on methodology, the text also continues the tradition of strong gender coverage, while expanding the coverage of social cognition and social neuroscience.


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Male nurse re-arrested over Stepping Hill deaths
POLICE have re-arrested a nurse in connection with poisoning deaths at Stepping Hill hospital.
Victorino Chua, 48, was first arrested in January 2012 on suspicion of tampering with medical records at the hospital in Stockport.
He was questioned on suspicion of three counts of murder and various counts of causing grievous bodily harm.
Chua was due to answer his bail next week, but was arrested at his home today after it is understood new evidence emerged in the inquiry.
In a statement, Greater Manchester Police said: "A man has been arrested in connection with the investigation into the deliberate contamination of products and tampering of medical records at Stepping Hill Hospital.
"Today, a 48 year-old man was arrested on suspicion of three counts of murder, 18 counts of causing grievous bodily harm with intent and offences of poisoning under Section 24 of the Offences Against the Person Act.
"He remains in police custody for questioning."
The alleged poisoning offences relate to the tampering of medical records and the contamination of intravenous medicines at the hospital.
The force is carrying out an investigation into the contamination of various medical products with insulin between June 1 and July 15, 2011 at the hospital.
Eight patients who were poisoned by contaminated products later died.
They are Tracey Arden, 44, Arnold Lancaster, 71, Derek Weaver, 83, William Dickson, 82, Linda McDonagh, 60, John Beeley, 73, Beryl Hope, 70, and Mary Cartwright, 89.
The deaths of Ms Arden, Mr Lancaster and Mr Weaver are being treated as murders.
Staff at Stepping Hill Hospital raised the alarm after noticing "unexplained" low blood sugar levels in patients.
Police later found a number of saline drips had been deliberately contaminated.
Detectives have reviewed and analysed the hundreds of interactions those patients had with a member of staff or visitor during their time at Stepping Hill.
The tampering affected patients on acute care wards for seriously ill patients.
Another Stepping Hill nurse, Rebecca Leighton, 28, from Heaviley, Stockport, spent six weeks in jail after being held over allegations she tampered with saline bags.
She was released and cleared of any wrongdoing in September 2011 when prosecutors said there was not enough evidence against her, but she was subsequently sacked for theft by hospital bosses.


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Craig Strickland's band, Backroad Anthem, is paying tribute to their lead singer after the 29-year-old was found dead earlier today following a hunting trip.
The group posted the following message to fans around the globe on Facebook: "Today we lost our brother, our best friend, our bandmate. Craig was the most amazing person whose passion for life couldn't be matched. Thankful to know he fought his way from the water to a hill and was lying in the shape of a cross on his back looking up to his Heavenly Father."
The band included a bible verse as well as a few final words thanking their followers for all of their kind wishes and prayers.
"We pray today for God to wrap his arms around Randy, Joanne, Helen, and the family, and to help us through this extremely difficult time. We want to thank every single friend, fan, and family member for your thoughts, prayers and love."
The bandmates concluded, "Today he is smiling down on us and we know he will always be with us. He will always be here to help guide us along the way. We love you Craig Strickland and we will forever miss you!"
Meanwhile, funeral service details were made public for Strickland's friend, Chase Morland, who also tragically lost his life on the duck-hunting trip.
Family and friends can gather at Butterfield Assembly Church in Van Buren, Ark., this coming Wednesday at 2 p.m. local time.
Helen Strickland posted a touching video Instagram earlier today showing the late singer before the two got married.
"I am so thankful for technology in this moment because I will always have this," she wrote. "I watched this privately prior to walking down the aisle, and so now I want to share this small excerpt with all of you."
Our thoughts go out to the Strickland and Morland families during this time.


text:
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hello my name is Samantha and im 14, my dad is the one who got me into drawing painting and all other kinds of art my favriot thing to draw is probably animals and candals. My favriot color is bright grass green and a purple...i live with my dad and step mom and i visit my mom on mondays and tuesdays...joint custedy!!!...well anyway send me a request to be freinds and i will surly accepet and send my and im anytime im always on...thanks for your time!!!
Tools of the trade
i draw with a regular pencil...uswally when im done drawing a picture i paint it with water paints or oil paints...!
Here we go again...dancing...its what i do best and its what i love to do every friday that i can i go to the teen dance club with all my girls and we get our dance going on no matter whos whatching!!!
Favourite books
1. heartbeat- this book is kinda short but very touching and emotional thats why i love it also very discreptive!!! 2. a chiled called it- this book is a true story about the worst chiled abuse case in califrnia state history, very amotional book again i cried when i read the book for the frst time!!! 3.the chocolate touch-this book is about a kid who makes everything he touches turn into choclate i like thisd book beacuse !!!...I LOVE CHOCOLATE...!!!
Favourite movies
my favriot movie has to be my sisters keeper..its a very sad movie about a girl who has cancer and she meets a bot who has cancer and he dies soon after they meet and begin dating...the girl wioth cancer has a sister who was born so that she could give her sister the body parts and bone densoty and other things that she needs to stay alive but after a while the sister gets tired of giving up her body parts and sues the mom for teling her to do it...VERY SAD MOVIE!!!
Favourite music
i love rap and hip-hop mostly beacuse i love to dance and im great at it to i can do hip hop dancing very well also (a little dirty lol) dancing is what i do best...i also love how up beat it is i lissen to it in the morning to get me going when i have school!!!
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text:
Darkest Hour
Darkest Hour stands apart from more routine historical dramas.
Darkest Hour stands apart from more routine historical dramas.
Not particularly keen on nuance or subtlety, this is a film in which everything, especially Stevens' decidedly manic take on Dickens, is pitched as broadly…
Roger Ebert on James Ivory's "Howards End".
"The Ballad of Narayama" is a Japanese film of great beauty and elegant artifice, telling a story of startling cruelty. What a space it opens…
An article about female actors and directors in contention for Oscars this year.
An article about my decision to not attend a country music concert because of racial fear.
An article about female actors and directors in contention for Oscars this year.
One of the best superhero films, in large part because the title character sincerely believes in values larger than any one person.
Stop watching movies made by assholes. It'll be OK.
A study of the 1965 film "The War Game" and its relevance a half-century later.
Jana Monji reports on the panel for "The Shape of Water" that followed after the film's AFI FEST screening.
Jana Monji reports on the screenings and atmosphere at this year's AFI FEST.
I would be tempted to say "The Distinguished Gentleman" paints a jaundiced view of lobbyists and bribery in Washington, if the latest headlines didn't make the movie seem almost soft on payola. The story involves a Florida con man (Eddie Murphy) who finds a way to get elected to Congress, and speeds off to the nation's capital to get rich quick. He finds that an easy thing to do.
The film is like a Capra movie where the early cynicism isn't just sketched in, it's plastered on. Murphy lounges around his Florida digs with a sexy cousin (Sheryl Lee Ralph) and assorted sidekicks, pulling scams on the gullible public. The most entertaining is his private phone-sex racket, where he blackmails the customers who dial his menu of Honolulu honeys and Scandinavian blonds. Ralph imitates some of the voices (she's especially good at the Scandinavian) and Murphy does the others.
Then the local congressman, Jeff Johnson (James Garner), kicks the bucket in mid-campaign. Murphy has the same name, and cashes in on the name recognition by getting his name on the ballot and winning the votes of everyone who thinks he's the other Jeff Johnson. Once in Washington, he realizes he can make the most money by selling his vote, and so he hires himself out to Dick Dodge (Lane Smith), the crooked chairman of the most powerful committee in Congress.
By now "The Distinguished Gentleman" should really be humming along, but it isn't, and the problem is with the slow pacing. This is screwball material, and Murphy, with his quick delivery, is ideal for a laughaminute roller coaster, but director Jonathan Lynn seems to stretch out the scenes instead of hurrying them along, and some of the dialogue seems to arrive with pauses between every word.
That's deadly when the movie discovers its heart of gold, as I suppose it must. Murphy falls for a pretty lobbyist (Victoria Rowell) whose uncle is one of the few honest men in Congress. Murphy discovers that he cannot simultaneously be dishonest and win her love, and love carries the day, but not before the audience is yawning.
"The Distinguished Gentleman" has a lot of good ideas for a comedy. One of them, based on Murphy's genuine gift for mimicing different accents, is the phone sex service. I've always wondered who would be dumb enough to pay several bucks a minute to talk to an invisible woman just because she claims to possess various physical and emotional attributes. This movie starts to tell us, and then backs off.
And Congress, too, is fair game for a movie comedy, with senators trying to keep a straight face while claiming they thought their summer home cost what no summer home in recent history has ever been built for.
A movie like Robert Altman's "The Player," aimed at Congress, would be delicious. But "The Distinguished Gentleman" prefers to give us measured laughs at a leisurely pace, and then it settles for the sellout upbeat ending. Ho hum.
A review of Netflix's new Marvel series, "The Punisher."
Stop watching movies made by assholes. It'll be OK.
One of the best superhero films, in large part because the title character sincerely believes in values larger than a...
The work of the late author, writer and director William Peter Blatty will continue to haunt the dreams of readers an...


text:
"Bon Appetite. Jan 2000. I will probably use canned crab to make this."
Garlicky Linguine With Crab, Red Bell Pepper and Pine Nuts
0 recipe photos
READY IN:25mins
Ingredients Nutrition
- 5 tablespoons unsalted butter
- 1 red bell pepper, finely chopped
- 4 garlic cloves, finely chopped
- 1⁄4 teaspoon dry crushed red pepper
- 1⁄2 cup dry white wine
- 12 ounces linguine
- 1 (8 ounce) bottle clam juice
- 1 lb fresh lump crabmeat, picked over
- 1⁄4 cup finely chopped fresh parsley
- 1⁄3 cup pine nuts, toasted
- freshly grated parmesan cheese
- Melt butter in heavy large skillet over medium heat. Add bell pepper; cover and cook 2 minutes. Add garlic and crushed red pepper; cover and cook 2 minutes. Increase heat to high, add wine and boil 2 minutes. Set aside.
- Cook pasta in large pot of boiling salted water until just tender but still firm to bite, stirring occasionally. Drain pasta, reserving 1/2 cup cooking water.
- Return pasta to pot. Add clam juice, 1/2 cup cooking water and bell pepper mixture.
- Cook over high heat until pasta absorbs half of liquid, about 2 minutes. Add crab and toss until heated through, about 1 minute.
- Mix in parsley. Season to taste with pepper. Divide pasta among bowls. Sprinkle with pine nuts. Serve, passing cheese separately.
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text:
Adapt to greater depths of relaxation. This acrylic model's EverClean Air Bath System provides a gentle massage using thousands of warm air bubbles. This system features a ring of 24 smooth air jets, double-intensity lumbar massage and variable-speed heated blower, all in a highly evolved tub with a 3 in. deeper water level. Deep Soak Drain sold separately (Model 1599.205).
- Durable and easy-to-clean acrylic with fiberglass reinforced construction
- Air jets fully surrounding the bathing well
- EverClean incorporates a patented antimicrobial additive molded directly into the water circulation piping to inhibit the growth of mold and mildew on the pipes
- Variable speed air blower with heater
- Form-fitted backrest and molded-in armrests
- Can be drop-in or under-mount installed
- Automatic purge with timer
- Must order Deep Soak® Max Drain (Model 1599.205)


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- Please select a date to see the proper prices!
Description of the accommodation:
Rooms, services Are you about to reserve a room in China? We are glad to introduce you the offers of <Szálláshely neve/Property type>, where both you and your family will be very welcome for a stay. The hotel is offering 68 nicely furnished rooms to stay in to those seeking accommodation in Shenzhen. The exact scope of services offered by Shenzhen Fuhui Business Hotel Shenzhen (including those for an extra fee) is available on the information sheet below.
Payment Depending on the selected date, room and price, you may need to provide credit card guarantee or advance bank card payment to finalize your reservation.
Arrival, opening hours The personnel can speak Chinese - China and English languages.
Shenzhen Fuhui Business Hotel Shenzhen rooms Rooms
- Please select a date to see the proper prices!
Accommodation services
Hairdryer, Desk in the room, Tea/coffee-maker


text: Amazon has started selling the ReVIVE Series Rapid GoCharge 2000mAH external battery pack for only $19.99. FYI, the original price was $51.99, so you can save $32. This battery pack charges USB gadgets such as iPod, iPhone, Android smartphones, BlackBerry smartphones, MP3 players, e-book readers, GPS units, camcorders, and other devices that charge via a USB port. It has a built-in 2000mAH battery that can be recharged via a USB port or an AC adaptor. Each purchase comes equipped with a micro USB and a Mini USB cables. [Amazon]


text:
Latest Stories
What is IGN's Pokemon Face-Off?0 Comments
April 1, 2011
Saving the Wii0 Comments
February 4, 2011
About This Game
- Summary
- Specifications
- Features
- Game Editions
The first Nintendo Wii entry in the much-enjoyed Pokemon franchise. The game is a battle stadium-type game between Pokemon, and it allows you to import your Pokemon from the DS games Pokemon Diamond & Pearl to play on the big screen. It is also the first Wii game to use the Nintendo WiFi Connect for online play with Pokemon fans from all over!
- Supported Functions
- Number Of Players: 1-4
- Online
- Local - VS # of Players
- Online - VS Number Of Players: 2
- 480p
- The first Wii game to include Nintendo Wi-Fi Connection play, allowing gamers to engage in online Pokemon challenges!
- Link Wii and the hand-held Nintendo DS by importing Pokemon Diamond & Pearl data into your Wii game
- Wii battles can be controlled using Nintendo DS
- Players can customize their Trainers in the game
- DS Battle Mode: This multiplayer mode is for those who also own Pokémon Diamond or Pokémon Pearl as well as Nintendo DS systems. Four players can get together and battle while using their very own Pokémon from their Pokémon Diamond and Pokémon Pearl games. All players use the DS as a controller in this mode. The same battle interface that is used in Pokémon Diamond and Pokémon Pearl is used while battling with friends
- Colosseum Battle Mode:There are 10 Colosseums (Battle Fields) altogether throughout Pokétopia. Many will need to be unlocked by playing through the others
Pokemon Battle RevolutionPublisher: NintendoRelease Date: June 25, 2007MSRP: 49.99 USD
Pokemon Battle RevolutionRelease Date: December 14, 2006MSRP: 5800 JPY
Pokemon Battle RevolutionRelease Date: November 22, 2007
Pokemon Battle RevolutionRelease Date: December 7, 2007


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|Bill Kondro - 2006
Lakeland College conferred its first honorary degree in 2006 recognizing former board chair and 2006 convocation speaker Bill Kondro with a bachelor of community economic development.
Kondro, who spoke at the Strathcona County convocation in April, the Lloydminster campus convocation in May and the two Vermilion campus ceremonies on June 3, told the graduates they had a passport to the world with their education from Lakeland College.
The 2006 Vermilion graduating class were the first to get to their feet when Kondro was presented the honorary degree by current board chair Doug Elliott (left) and president Dr. Brian Larson (right).
At that time Kondro chaired the Lloydminster campus capital campaign that is raising funds for a new academic wing in Lloydminster. The wing, officially opened in 2008, bears Kondro's name.
"Bill Kondro is a great friend of Lakeland College and it was our privilege to honour him in this way," says Dr. Larson.
|Owen Baker - 2011
For the past 10 years, Lakeland has collaborated with a consortium of oil and gas companies led by Keyera to deliver one of the largest petroleum industry certification programs in Canada.
Owen Baker, the chief inspector and manager of integrity and capability development at Keyera, has played an integral role in the program. He helped create and implement Keyera's Competency Management Development System (CMDS), a training and education program designed for people working in either oil and gas field collection or plant processing capacities.
Lakeland has awarded more than 1,800 petroleum industry certificates since the collaboration began
Mr. Baker (right) was presented with an honorary Bachelor of Applied Business degree by Lakeland president Glenn Charlesworth (left).
Lakeland College presented its very first honorary degree in 2006, and has only presented one other--in 2011.
Last updated on


text:
Ser emprendedores / dia 4
The fourth day of the workshop is the hardest one: motivation is still high, but it is the time to talk about numbers, management and accounting.
The workshop followed a simple program, borrowed from the European project ABACO, and presented through a specifically created example.
The result was excellent: all the participants estimated their own budget realistically, and identified some basic parameters to control their business (for example, establishing a weekly income).
We discussed about distinguishing the financial resources of the home and the enterprise; about reinvesting; about the importance of retirement savings (in Ecuador it is non common…) and about "how much is my work worth?".
Part of the day was dedicated to group exercises – business is not to me started alone – and to the witness of Francesca Paglia.


text:
Twenty-one Trailer (1991)
04 October 1991 Drama, Comedy 92 mins
Katie is a free spirited independently minded 21-year-old. The film follows her as she reflects on the men in her life. Along the way we meet her drug addict boyfriend Bobby, her lover Jack, close friend Baldy, and her father.
Watch the official Twenty-one 1991 trailer in HD below or find more Twenty-one videos on Vidimovie.


text:
No screenshot or proof??
i have a bs id sergent major (white) got a isa 30 day bar set 60 day hk f 30 day smf 60 day who want buy rm200 i acept mol i will give id 1st than u give me molu can add me in facebook if u want https://www.facebook.com/benjaminz.tan if want can pm in facebook i can give u id 1st
Last edited by benjaminz.tan; 12-18-2012 at 03:52 AM.
No screenshot or proof??
RM 200... You seriously think its worth so much? Think again
..Are You Joke Buddy ? sergent major (white) = RM 200 ?
No proof go licky licky some thingy
Injector Coder for CFNA from 2011-2013