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Lake Creek Valley
Lake Creek is only minutes from the fine restaurants and shops of Edwards yet offers residents the space to be completely secluded. Favored by horse enthusiasts and lovers of nature, Lake Creek's ranch sized home sites leave residents to their own initiatives.
Lake Creek Valley Real Estate Listings
705 Whiskey Ridge Edwards, CO
$33,000,000 €28,114,086
Residential, Single Family
- 7 Beds
- 10 Baths
- 11,869 SqFt
- 105.63 Acres
100+ acres in Lake Creek Valley, 4 mi. from downtown Edwards. Stunning home designed by Arch. Digest Top 100 recipient, Annabelle Selldorf (www.selldorf.com/projects/walden-house). 10,515 +/-sf house and gym with magnificent views of NY Mountains....
1531 Lake Creek Rd Edwards, CO
$9,500,000 €8,093,449
Residential, Single Family
- 5 Beds
- 5 Baths
- 5,832 SqFt
- 2.76 Acres
An exceptional property set on nearly 3 acres and highlighted by over 450 feet of Lake Creek frontage with water rights. The setting, coupled with charming, European architectural make this home one of the most unique properties in Lake Creek.
1939 Saddle Horn Way Edwards, CO
$6,295,000 €5,362,975
Residential, Single Family
- 5 Beds
- 7 Baths
- 8,875 SqFt
- 4.23 Acres
New Mountain Contemporary home has everything Colorado has to offer, with unbelievable views, private setting and abundant wildlife, yet only minutes from amenities and skiing. This home was designed for comfort and ease with a generous master bed...
157 Pilgrim Dr Edwards, CO
$5,995,000 €5,107,392
Residential, Single Family
- 6 Beds
- 8 Baths
- 10,228 SqFt
- 10 Acres
Discover an immaculate 10,000 SF English estate within the private gated community of Pilgrim Downs. Picturesque setting with exquisite gardens, tall aspens, and Monet bridge over the delightful brook set upon 10 acres. Built by Andy Beck, no exp...
1470 Lake Creek Rd Edwards, CO
$5,350,000 €4,557,890
Residential, Single Family
- 4 Beds
- 6 Baths
- 5,400 SqFt
- 4.46 Acres
On a nearly 5 acre alpine garden setting with flowering crab apple trees, wildflowers,green space and dramatic views to the Swatch Range. The passion for detail and exquisite finishes are reflected in this home built by the owner,a well known loca...
775 Holy Cross Dr Edwards, CO
$4,500,000 €3,833,739
Land, SF/MF/Acreage
- 1,742,400 SqFt
- 40 Acres
Every so often a piece of land comes to the market that epitomizes the western living dream. Now is one of those times. This 40 acre parcel at the top of Lake Creek Valley is nestled under the Sawatch Range and has beautiful views to the mountain ...
2000 W Lake Creek Rd Edwards, CO
$4,500,000 €3,833,739
Land, Farm/Ranch
- 1,667,912 SqFt
- 38.29 Acres
Though located just 6 miles to skiing in Beaver Creek Resort & 18 miles to Vail, this exceptional 38 acre parcel with abundant water rights, feels a world away in prestigious Lake Creek. The ideal location for a legacy residence that has accessibi...
420 Saddle Horn Way Edwards, CO
$3,500,000 €2,981,797
Land, SF/MF/Acreage
- 1,524,905 SqFt
- 35.01 Acres
Build your dream home. Beautiful 35+ acre lot located in highly desirable Lake Creek Valley. Minutes away from the dining and shopping of the Riverwalk Center in Edwards and nearby Vail and Beaver Creek Resorts. The total floor area for all buil...
765 Saddle Horn Way Edwards, CO
$3,500,000 €2,981,797
Land, SF/MF/Acreage
- 1,524,905 SqFt
- 35.01 Acres
Build your dream home. Beautiful 35+ acre lot located in highly desirable Lake Creek Valley. Minutes away from the dining and shopping of the Riverwalk Center in Edwards and nearby Vail and Beaver Creek Resorts. The total floor area for all buil...
265 Jackman Ranch Rd Edwards, CO
$2,975,000 €2,534,527
Residential, Single Family
- 6 Beds
- 8 Baths
- 6,280 SqFt
- 4.91 Acres
Perched on a private hillside in pristine Lake Creek Valley, this gorgeous, custom home enjoys stunning views of snow capped peaks, abundant wildlife and all day sunshine. With nearly five acres, the property is approved for two horses and additio...
106 Pilgrim Dr Edwards, CO
$2,950,000 €2,513,229
Residential, Single Family
- 5 Beds
- 7 Baths
- 7,312 SqFt
- 4.83 Acres
Wonderful western home on 4.8 acres. Borders 90+ acres of open space. Charming floorplan, large great room, master on main floor. Second master upstairs, 3 car garage, wine cellar. Quiet living close to skiing, shops and National Forest access. Ho...
341 Jackman Ranch Rd Edwards, CO
$2,495,000 €2,125,595
Residential, Duplex
- 7 Beds
- 5 Baths
- 4,136 SqFt
- 6.57 Acres
Unique development opportunity in the pristine Lake Creek Valley. Private 6+ acre lot with a stunning building site on the ridge line above a duplex that currently sits on the lower edge of the property. Boasting some of the best views of the Saw...
The data relating to real estate for sale on this website comes in part from the Resort Data Exchange program of the Vail Multi List Service Inc. and Mountain Region Multi List Service. Real estate listings belonging to brokerage firms other than Engel & Völkers are marked with the RDX logo or icon. The detailed information about them includes the listing brokers name.
The information being provided by the Vail Board of REALTORS® is exclusively for consumers' personal, non-commercial use, and it may not be used for anypurpose other than to identify prospective properties consumers may be interested in purchasing. The data is deemed reliable but is not guaranteed accurate by the MLS.


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Turkey With a Side of Sand
Sunday, November 19, 2006
My mother's words echo in my head, tugging me back year after year.
"A turkey sandwich always tastes better with a little sand," she is saying. We are standing barefoot at a beat-up wooden picnic table, unloading the remnants of the previous night's Thanksgiving dinner. Homemade cranberry sauce, brie, Dad's special stuffing, key lime pie and, of course, the prime attraction: turkey sandwiches.
The plates are paper, the glasses are plastic, but the salt shaker is cut glass. We may be in itsy-bitsy bikinis, risking splinters in certain delicate areas, but we have our standards -- especially when it comes to holiday meals.
While friends up north shovel snow, replaying ancient family grudges and fighting hordes of Black Friday bargain hunters, we bask in the glories of Delnor-Wiggins Pass State Park, an exquisite natural barrier-island beach along Florida's Gulf Coast.
"I hear Boston got more snow," chortles my youngest sister, Liz, who arrived from frozen New England a day earlier. Yes, we smugly agree, we're pretty darn smart.
When my mother first suggested Thanksgiving in Naples, Fla., it sounded like blasphemy. Aren't holidays meant to be endured in the family homestead, rife with memories of the times you were banished to your room for refusing to eat vegetables? Can you really call it Thanksgiving, we wondered, if the thermometer reads 78 and your biggest worry is which sunscreen to apply, the golden goddess SPF 8 or the I'm-so-very-responsible 30?
Still, my parents had been spending winters in Naples, and the trek back to Pennsylvania was becoming a burden. So several of us kids, skeptical as we were, agreed to try an alternative Thanksgiving, far from the traditions of our youth.
It didn't take long to realize that, once again, Mother knows best. That first trip, five years ago, we discovered the joys of cooking in shorts and slipping out for a quick nine holes of golf while the turkey roasted. To our surprise, gravy tastes just as good out of a flamingo coffee mug as out of any fancy china gravy boat.
Gradually, we became more civilized -- a serving platter showed up one year, linens and roasting pan the next. Finally, last fall, my electric carving knife relocated permanently to Naples.
A new tradition was born. And though the journey this year is much longer from my new home in Mexico, I cannot resist my mother's call.
A Calm Getaway
Naples, situated on the edge of the Everglades, was founded in 1887 by a group of wealthy Kentuckians. With its mild climate and ocean setting, the city does a credible job of evoking its namesake on the Italian peninsula. From its earliest days, it has been popular with high-society types, including movie stars Greta Garbo and Gary Cooper. Today, Naples is awash in designer boutiques, gated communities and two -- count 'em -- Ritz-Carlton resorts. It also has a reputation as a retirement haven. Translation: yawn.

subset: commoncrawl


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Klondike Derby
Our Klondike derby is an annual event held during the winter months and is based on the heritage of the Klondike Gold Rush. BSA units have been running Klondike derbies since 1949.
The derby is a one-day event, consisting of several stations where patrols/units must test their Scoutcraft skills and their leadership abilities, earning points towards a total score.
The unit must transport their gear on a homemade sled pulled by the Scouts.
2017-2018 Scouting year
Tentative Dates: January 19 (Fri) – January 20 (Sat), 2018 at Greene Valley


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Autodl-IRSSI allows rtorrent to monitor your trackers Announce Channel and to automatically start downloads for you based upon your filters. This is a good time to point out the basic differences between RSS and IRSSI. With RSS when you set a filter it acts upon the rss feed supplied by the tracker which it grabs every 6-30mins and acts upon the whole feed which could be as many as 100 torrents at once, so it sees into the past as well as the present. With IRSSI it is continuously monitoring a news feed from the tracker rather like the news headlines at the bottom of your favourite TV News program, once the news has scrolled across the screen it is gone forever. So you cannot use IRSSI to grab "past" releases. But because it is monitoring the live feeds as soon as a new release hits your trackers, your filters are applied and the matching torrents are passed to rtorrent to download immediately.
In this tutorial we are going to set up a filter to grab your favourite HD TV shows and save them in a newly created folder called TV Shows.
There are two parts to this process, the first is loading passkeys or cookies into the program to allow you to download from the tracker with your site authorisation, and the second is setting up the Announce Channel to monitor.
At the top of rutorrent page you will find the autodl-irssi tab (in default skin this is a white arrow on a green background). Click the tab
Select Trackers.
For this tutorial we will use IPTorrents as our example but this basic method is the same for most trackers. Scroll down the left hand panel to find the tracker you want to monitor and highlight it.
In the right hand panel carry out the instructions and paste the information in the box below the instructions, autodl-irssi will extract the required data, now click OK.
Click the autodl-irssi tab and this time select Announce Channels
Scroll down the left hand panel and highlight the tracker you are adding
Now make a note of the Server and Channel data for use in the next stage. Click Close Click the autodl-irssi tab and this time select IRC Servers
Click New
Now you have to enter the IRC Server information, which you will have noted from Announce Channels window above. In this case for IPT we enter the server as irc.iptorrents.com and the port 6667 (this is the standard port for irc and you may need to check with the tracker to confirm this). Next in the Nick box enter the username you use to log on to the trackers main site and in the Password box you enter your site logon password. In the Email box enter the email address associated to your tracker account.
Now we will define the Channel to monitor for new releases. Click on New and in Channel box enter the Channel information, which you will have noted from Announce Channels window above. In this case for IPT we enter #ipt.announce (but in most cases it is just #announce). Now enter your tracker logon password into the Password box. Most trackers need you to just register your nick on their server this is done in the Invite Command box and consists of a message to the nick server with your tracker logon password, if this does not work then a quick question to site staff will let you know what information is required here. Now click OK
Now we will check that all has been setup correctly. This is done from the servers Dashboard. Click on IRC Tools
Now click on Access IRSSI
On the next window click Status tab and the connection status window will be loaded. What you are looking for is a successful connection to the tracker you have just added, here I have highlighted the relevant lines in blue. Also there should be a tab at the bottom with the channel name. In this case #ipt.announce.
Now click this announce tab and a window will open showing the releases as they are uploaded onto the tracker site. Here you see the time the torrent is uploaded to the site (21:49), the name of the announce bot (IPT), then the category for the torrent (TV/XVID) which corresponds to the categories listed on the trackers Browse page, followed by the torrent name (Mighty Planes S02E06 SOFIA 747SP HDTV XViD-AFG) followed by the download URL (iptorrents.com/details.php?id=1092518) and finally the size of the torrent (369.773MB). All of this data apart from the url can be used in the filters
Click on the autodl-irssi Tab and select Filters
Now click New. A filter called <no-name> will be created.
With the General tab selected we can give the filter a name to remind us what it is filtering so for this example I will call it HD TV Shows. So in the Display Name box we put HD TV Shows, now we have to tell it what trackers to monitor so click Match Sites, scroll down to the tracker you want to monitor and click the tracker name ( if you wish to monitor more than one tracker continue scrolling to the next tracker and Ctrl + Click the name so both are highlighted) Now Click OK, their abbreviated names will appear in the box to the right separated by a ","
For now that is all we need to do on the General Tab, It should look like this.
Now click the TV/Movies Tab. This is where we enter the show filters.
Firstly in the TV Show/Movie box we enter a search string for the show with a "*" at each end. This does not need to be the full name and words do not have to be separated by "." also capitalisation does not matter. In this case we want to download Marvels Agents Of Shield, The next three parts are optional but if the trackers you use place many different resolutions/encodes or sources in each category then it is good practice to fill them. To select a resolution click the Resolution button and click on the resolution required. The same process for Encodes and Sources.
Should you wish to download several shows from the same tracker(s) with the same resolutions/Encodes/Sources then you just type more show filters into the TV/Movies box and separate each show with a ",". To add more Resolutions/Encodes/Sources then click the relevant button and select the extra ones, each will be added to the existing separated by a ",". If you need to remove one just click the relevant button and click the one to remove.
In this window we have chosen to download both Marvels Agents Of Shield and The Following in 720p and both h264 and x264 encodings and also in both HDTV and Web-dl sources.
Now we have to tell autodl-irssi what to do with our downloads, so first we have to create a new folder for the data to be stored. In rutorrents main window click on Explorer tab and navigate the right window to the root directory (the navigation bar will just contain a "/"), hover over an existing folder and right click and select Create>New Directory.
Now type in a Name for the directory and click OK
We have now created a new folder in the root directory called TV Shows.
Now Click the Action Tab and from the drop down menu select rtorrent.
Now in the Folders section click the browse button on the right , now navigate to the new folder we just created. If you use Labels to sort your torrents or to enable selective unraring then type the Label on the Label box. You can select any of the Ratio Groups you have previously created so that once the torrent has satisfied the ratio requirements it is automatically Stopped/Removed/Deleted/set to a predefined channel. If you want to restrict the download and or upload speeds select the relevant channel from the drop down box, do the same with the priority box too if you want to select something other than Normal. Now you can click OK.
Congratulations you have just created your first Autodl filter. Now all you need to do is sit back and wait for your first torrent that matches your filter to start downloading and seeding
If you wish to know more advanced settings for autodl-irssi look at the Advanced Settings for Autodl-IRSSI Tutorial.


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English Pirate Facebook: "Arrr, this be pleasin' to me eye"
So I jumped on facebook a couple minutes before midnight last night. A friend from school, Chris Rothbauer, had just posted a fantastic status.
Chris Rothbauer status: Haha I just discovered you can change your Facebook language to Pirate English and I love it!
Marshall Jones Jr. comment: Are you serious? Dude, that rocks! Tell me how.
Chris Rothbauer comment: 1) Scroll to the bottom of your Facebook page. 2) On the bottom left corner, click English:US. 3) When the language selection appears, click English Pirate.
Marshall Jones Jr. comment: Only a couple minutes left in the day, but that's one of the coolest things I've learned all day. I'm totally statusing this up for all my friends soon. Thanks. :>)
It says beta. I hope they keep it.
Yes, it is that hot. Check it.


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If an item you ordered from TextbookRush does not meet your expectations due to an error on our part, simply fill out a return request and then return it by mail within 30 days of ordering it for a full refund of item cost.
Learn more about our returns policy
Limited time offer:
Get the first one free! (?)
All the information you need in one place! Each Study Brief is a summary of one specific subject; facts, figures, and explanations to help you learn faster.
List price: $12.95Copyright year: 2006Publisher: Sterling Publishing Co., Inc.Publication date: 10/28/2006Binding: PaperbackPages: 128Size: 8.00" wide x 8.25" long x 0.50" tall Weight: 0.660Language: English
When you think of fiction's strong women and strange worlds, think Carol A. Strickland.Although born in a small town in Illinois noted for its Nineteenth Century demonic possession cases, Carol A. Strickland claims that all those voices inside her head are a result of having stories to tell and books to write. Even so, her strange devotion to and study of Wonder Woman would seem to indicate an abby-normal brain.A one-time comics letterhack and now an outspoken member of various comics message boards, Carol has found herself the basis for two comic book villains (at times her opinions have not been taken well by the books' creators) (both villains were soundly thrashed) (and both, for some perverse reason, were male), had one superhero wear her costume design... and she knows that Brad Pitt is eight years and two days younger than she. Sigh.Applesauce and Moonbeams is her fourth published novel, and more are on the way!Carol wants to write like her favorite authors: to be able to portray the honest emotion and surprises that you find in Julia Quinn; to be bold and funny as Jenny Crusie; to find the multi-layered imagination and heart that Lois McMaster Bujold uses; and to enjoy the sales success of Janet Evanovich.Carol has also become an award-winning painter from her home in North Carolina. She exercises this skill in her secondary hours (both of them) along with writing as she waits for the lottery to free her 9-to-5 time to more fulfilling pursuits.http://www.CarolAStrickland.com
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GraphicRiver Wine Labels Set 12189033
Category: Stock Vector | Comment: ( 0 )
GraphicRiver Wine Labels Set 12189033
Stock Vector \ Objects \ Food
Sign \ Sticker \ Restaurant \ Quality \ Symbol \ Wine \ Winery \ White \ Warehouse
Stock Vector - Wine Labels Set 12189033 by macrovector @ GraphicRiver
Stock Vector \ Objects \ Food
Layered: No; Graphics Files Included: JPG Image, Vector EPS; Minimum Adobe CS Version: CS.
Special collection best quality grape varieties and premium wine brand names labels emblems abstract isolated vector illustration
Travel Icons Black Set; Books Flat Icon Set; Buyer Icons Set; People With Dogs Set; Seedling Flat Icons Set; Zodiac Icon Flat; Healthy Food Flat Icons Set.
Keywords: best, brand, classic, collection, crown, decorative, design, emblem, farm, grape, grapevine, icon, label, pattern, pictogram, print, quality, red, restaurant, set, sign, sticker, symbol, tag, template, vine, warehouse, white, wine, winery.


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Great Ways To Make Vacation Exciting And Hassle-free!
|Date Added: May 03, 2016 07:13:14 AM
|Author: Arturo Reno
|Category: Travel: Airlines
|Feel you understand every thing you should know about travelling? You might like to reconsider. In this article, you are likely to get recommendations and knowledge regarding traveling. A few things maybe you have previously known, some things you haven't. In either case, knowing these pointers are only able to assist you in your trips. Success a fitness center before you decide to board your air travel. A long air travel can be extremely uninteresting. You could find your rear or hip and legs pains from sitting in exactly the same placement for too long. When a workout is unthinkable, then at the very least conduct some extending before you board. Not all health insurance ideas cover you if you traveling in foreign countries. When coming up with a plan to travel to global spots it's a smart idea to check into buying health-related insurance coverage to your vacation. So, prior to going you might want to study what kind of medical insurance is open to you and what the fees could be. At times it's preferable to choose locations traveling in which you have loved ones in your community. It can save you money accommodations by keeping yourself having a close up friend or family member if you traveling, you can just allow it to be around them by taking them to supper. They may also show you all the cool internet sites to check out considering that they ought to be really acquainted with the spot. Don't miss the coach. If you want to vacation a modest length to the up coming spot, make use of the tour bus as an alternative to more costly cabs or leasing cars. A lot of vehicles, particularly in significant towns, are usually neat and modern. Not only will you spend less, but you will definately get an outstanding possibility to people-observe and get acquainted with the local people. In case you are going to Mexico or the Caribbean while in hurricane season, it's an intelligent concept to get travel insurance plan, if it's affordable. Unfortunately, by the time a hurricane warning is forecast, it's far too late to purchase insurance, so get it during the time which you book your holiday. For the selling price, you can aquire "Cancel for Any Reason"� insurance plan that permits you to end your vacation for motives not presently given with your coverage. Find out if you will need any shots prior to visiting your preferred vacation spot. You must visit your local health care professionals and make them suggest shots and in addition ask them about almost every other safeguards you need to consider while away. You don't would like to danger acquiring contaminated with a avoidable, dangerous disease throughout vacation. Consider cookie sheets along if you are vacationing in a vehicle with kids. Cookie bedding can be used for numerous purposes, which include goody or dinner trays. They could also be used being a colouring work desk and video game desk. Young children will like utilizing the containers making use of their magnetic words and phone numbers, keeping them hectic and satisfied throughout the push. A straight air travel is not really just like a nonstop trip. Both forms of air flights indicate there is no need to change airplanes however a direct flight may possibly stop at other airport terminals prior to your final location. This foliage far more possible areas for delays, leading you to past due to arrive at your location. Convert your hard earned money several days before your timetabled leaving. Also, validate with your lender or credit card owner that your greeting cards works extremely well when you're going to an international country. It's also useful to let them know that you are vacationing therefore they won't "refuse" an overseas transaction. Get some vacationer inspections on hand that can be used worldwide at the same time. Consider dining places in the region that you are going to be holidaying in. You may accumulate very useful specifics of the various locations to enjoy via online journey sites where others who have dined there keep very beneficial evaluations that could help you save money and time by staying away from the locations with bad critiques. Ensure that your passport is present and is not gonna end during your journeys. When it is receiving close to expiring you will need to get a a different one. This process could take the time to acquire through which means you must submit an application for a single 3 to 4 several weeks ahead of your travel time. You may think you already know every thing about travelling, but chances are you will find stuff you almost certainly have no idea. If you loved this short article and you would like to obtain additional information regarding airline tickets to kindly visit the web page.


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Bullying in Kindergarten?
One of the hardest parts about being a full time working mommy outside the home was that I was unable to make a lot of "mommy" friends in my son's preschool. Since he had to be at school a 9am, a lot of the mommies became friends with my husband or my mother.
Thankfully all of that changed when so many of the preschool parents showed up for my youngest sons 2nd birthday in the snowstorm. One of the mommies I fell in love with instantly, she was one of the sweetest purest spirits I had ever met and her daughter and my son had the best friendship. Finally, I have a mommy friend. You guys have no idea how hard this is when you are not involved in the pick up/drop off/daytime activities because you work full time.
I randomly ran into her and her daughter last week and she didn't have her normal happy face on. We were standing in a very busy commuter hub with hundreds of rush hour commuters hustling around us but something told me to stop and see what's up because she is never like this.
She confided in me that her daughter was being bullied in school and it was tearing her apart. Another child had been taking her snacks at snack time.
No one wants their child to be bullied. As she stood there crying in frustration I had to pull her into a hug and held back my own tears because I felt every single bit of her pain. She had been in contact with the teacher multiple times and was beginning to feel helpless. She gives all she has to her daughter and like the rest of us, she wants her child to be happy in kindergarten.
I find it so difficult to really accept that there is a bullying culture in Kindergarten. 5 year olds should be getting used to being in school, social skills, numbers, writing, etc. I personally was bullied in the second grade for 6 months. There was a girl who was in my class but physically much bigger than me that stole my snack every single day. I didn't tell my mom because somehow she had convinced that if I did my mom wouldn't believe me. I had no idea that it was wrong, so it continued to happen. It wasn't until I was teen did I recognize it as bullying.
I told her that she had to be relentless with the teachers until it stopped. If that meant she had to show up everyday at snack time to make sure that it doesn't happen then so be it. She does have a small relationship with the parent of the bully but she doesn't feel comfortable with the confrontation.


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Supplier Homepage Product SPRING SNAP BUTTON 2017 New Garment Accessories Small Spring Metal Button
2017 New Garment Accessories Small Spring Metal Button
|FOB Price:
|Get Latest Price
|Min. Order:
|1,000 Pieces
|Shekou, China
|Production Capacity:
|Payment Terms:
|L/C, T/T, D/P, Western Union, Paypal, Money Gram
Request a custom order and have something just for you!Send Customized Request
Basic Info
- Model NO.: SJ4009#A
- Type: Spring Snap Button
- Usage: Bags, Toys, Sweater, Trousers, Jacket
- Color: Monocolor
- Resin Button: No
- Stock: Stock
- Origin: China
- Material: Metal
- Shape: Round
- Style: Fashion
- Element: Fashion
- Adjustable: Non Adjustable
- Specification: 11mm
- HS Code: 96061000
Product Description
Product Description:
- Product Name:2017 New Garment Accessories Small Spring Metal Button
- Size:11MM or as your requirement
- Material: brass
- Color:Painted and Electroplated as your requirement
- Quality control:Before packing 100% inspection,spot inspection before shipment.
- Delivery time: sample within 7 days, bulk within 10 days.
- MOQ: No MOQ
- Packing: As per buyer's requirement
- Trade term:EX-WORK, FOB SHENZHEN or FOB the port at China.


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Fourth time lucky! Incredible overhead goal after hitting post three times goes viral [Video]
Three times is usually the charm but not on this occasion as Sport Huancayo striker Kleyr found out!
A stubborn football would not cross the line and seemed to be magnetically attracted to the bar only to finally feel the sweet relief of the back of the net thanks to a brilliant overhead from the Brazilian forward.
Before that the ball had bounced off the woodwork an incredible THREE times!
As the video, uploaded by Goal, shows, the ball is eventually put across the line after Kleyr gets it past the Real Garcilaso in the Peruvian domestic league; Huancayo went on to win the match 2-1.


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Jaypro™ Aluminum Soccer Goals
Lighter than steel, rust-proof aluminum square-post goals are the top choice for competition.
Choose from square or round portable, permanent or semipermanent outdoor soccer goals in durable aluminum to give your soccer field the equipment it needs for competitive play! These goals are built to last and are the only aluminum permanent and semipermanent options we offer.
- Great for official play at 24'W x 8'H x 10'D.
- Set a goal and leave it alone for a full season of repeated shots and competitive play!
- Choose a square or round aluminum frame that has been powder coated to provide outstanding durability and a great look that lasts season after season through all weather conditions.
- A separate wheel kit for semipermanent and portable options make it easier to move the goals on and off the field during the offseason.
- Semipermanent goals mount into sleeves, which are installed in the ground for greater stability. Safety features help them resist tipping. Permanent goals mount permanently into the ground for the maximum stability and safety and will never tip.
- 1-5/16" OD galvanized steel backstays provide counter weight to the goals to prevent them from tipping and to ensure user safety.
- An Easy Track™ net attachment allows for quick assembly. Simply clip the net to the goal with rigid plastic clips that stay in place and recess into the goal to ensure a smooth surface.
- Meets NCAA®, NFHS®, FIFA, and ASTM specifications.
Jaypro™ Aluminum Soccer Goals Options
Jaypro™ Aluminum Soccer Goals are available in all-in-one packages or pairs, in round or square posts. Ground anchors and wheel kits sold separately. Truck delivery on goals.
- All-in-One Packages. Includes 2 goals, set of 8 ground anchors, and 1 wheel kit.
- Portable Round Goals
- Portable Square Goals
- Pair of Round Goals
- Portable Goals, 420 lb
- Semipermanent/Permanent Goals, 306 lb
- Pair of Square Goals
- Portable Goals, 416 lb
- Semipermanent/Permanent Goals, 240 lb
- Accessories
- Ground Anchors
- Wheel Kit (for 2 Goals)


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Please be sure to look at our FAQ below and see if your questions can be answered there. If you still have any additional questions or concerns, please feel free to contact the race director at firstname.lastname@example.com.
When is the CHI St. Joseph Health - Republic of Texas Run?
The CHI St. Joseph Health - Republic of Texas Run will be held on Sunday, February 25, 2018.
Where will the event take place?
The start and finish lines will be at George Bush Library, 1000 George Bush Drive West, College Station, Texas 77845.
Can I use headphones?
While we do allow headphones in the CHI St. Joseph Health - Republic of Texas, we recommend you do not wear them, as they can impede your ability to hear volunteer and race official instructions.
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Ingamells Street, Prospect
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Who lives here?
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Got a burning question? Why not ask the locals! Simply ask your question below
Ingamells Street
"A small community set back from Stanley Street"
Ingamells Street residents enjoyed for a number of years exclusive use and access to the adjoining reserve until Summerise Court completed the development. Homes in Ingamells Street were built in the 1980s and are generally small having been built as stepping stones to bigger properties. It is well located in terms of shops, schools and public transport.
Recommended for
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- Families with kids


text:
Lower Normandy,
Fields and 1
Players at Segrie-Fontaine
Find below the next soccer games at Segrie-Fontaine
Play and organize soccer games with your friends at Segrie-Fontaine.
Jordan Gerard
25 years old
Terrain de Foot
A friend has given you a game code?
A "game code" gives you an exclusive access to a game organized on Footinho.


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DU Correspondence Courses
Delhi University, also School of Open learning offers courses UG and PG through distance learning. Applicants if you are eagerly waiting for DU Correspondence Courses offered by University, then you need to scroll down this page and get the list of Delhi University Correspondence Courses. There is no differentiation in the course curriculum followed by School of Open learning and other constituent colleges and departments of the University of Delhi. We are shortly bringing details on DU Correspondence Courses 2017. So, don't be late to get latest update regarding the same, stay tune with our portal and Be the first to know latest news by our portal.
Delhi University is one of the foremost universities in India in terms of size and academic value. The Delhi University community, which includes, the likes of students, teachers, the Delhi university union, and the massive administration workforce is by far larger than any University in India. Therefore, it becomes increasingly difficult to keep track of the individuals who have been a part or are a part of Delhi University in any capacity.
University proffers various post graduate courses such as M.A (Hindi, History, Political Science and Sanskrit) and M.Com (Commerce) and under graduate courses such as B.A (pass), B.A (Hons) (English and Political Science), B.Com and B.Com (Hons). You can acquire complete details in concern to DU Correspondence Courses from under beneath section of this page created by team of recruitmentresult.com.
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text: Concorde Motors called me. They said they have tie up with 5 companies for "hassle free" insurance - Royal Sundaram, Tata AIG, Bajaj Allianz, ICICI Lombard and one more name which I forgot. Yes, if you read it twice and still couldn't believe, its true. They dont have Future Generali on their list at all! No wonder I wasn't called by them earlier for renewal. So weird. They are co-managing Fiat and they don't have FG on their list? On top of it, when I ask for a quote from the above 5 companies through Concorde, the lady asks me to scan and email or fax the current policy cover note in order to generate the quote. Now I have neither a scanner nor a fax machine at home. SO basically she put down the phone saying 'I'm sorry sir I cannot offer you a quote'. WTF! All others simply asked for basic details! How much is your IDV and premium?


text:
Norman Maclean Quotes About WaterQuotes about: Water
Eventually, all things merge into one, and a river runs through it. The river was cut by the world's great flood and runs over rocks from the basement of time. On some of the rocks are timeless raindrops. Under the rocks are the words, and some of the words are theirs. I am haunted by waters.
Of course, now I am too old to be much of a fisherman, and now of course I usually fish the big waters alone, although some friends think I shouldn't. Like many fly fishermen in western Montana where the summer days are almost Arctic in length, I often do not start fishing until the cool of the evening. Then in the Arctic half-light of the canyon, all existence fades to a being with my soul and memories and the sounds of the Big Blackfoot River and a four-count rhythm and the hope that a fish will rise.
I sat there and forgot and forgot, until what remained was the river that went by and I who watched. On the river the heat mirages danced with each other and then they danced through each other and then they joined hands and danced around each other. Eventually the water joined the river, and there was only one of us. I believe it was the river.
Norman Maclean
- Born: December 23, 1902
- Died: August 2, 1990
- Occupation: Author
- Cite this Page: Citation


text:
Saturday morning: island cold snap low twenties, salty puddles iced shut prairie grass stiffened like driftwood early, a rush outside turquoise sky nose, lobes, lips, lashes, lungs frozen before the top of the hill I fall head over heels for days like this,
Tag Archives: weekending
Weekending: Oh, Snap
Weekending: Training Wheels
off to a rocky start after our three year old minivan's engine blew up we drove it, unfixable smoking into our driveway Mama, maybe it needs training wheels? wishful thinking, luckily we live on an island could be worse, as all things can. Friday's night: restaurant on a cliff foie gras, wine, espresso, apple pie […]
A Weekend in Season
Friday began with a stomach ache of the worst kind nerves so thick I couldn't finish my coffee eight years since I lead a classroom convinced they'd call me Mrs. My Last Name and I wouldn't turn around Kindergarten sub, my daughter's teacher for the day puppets, songs, dance breaks, days of the week, numbers […]
Weekending: Hello, December
I walked around all week with the wet, heavy blanket of a head cold spent one full daylight under covers tried the wellness trick, Friday's fancy dress, big smile, long meetings still, throat sore, heels heavy, Lucy honored at her school: a leadership award for Work First, Play Later she dressed herself fancy, gave us […]
weekending:: october's ending
I. I'm listening to The Lumineers loud, like ohh-goodness-I-have -neighbors loud a perk of three little girls in school


text:
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To determine the long-term clinical significance of molecular upstaging in histopathology-negative, paraffin-embedded (PE) sentinel lymph nodes (SLNs) from melanoma patients.
Histopathologic evaluation can miss clinically relevant melanoma micrometastases in SLNs. This longitudinal correlative study is the first 10-year prognostic evaluation of a multimarker quantitative real-time reverse transcriptase–polymerase chain reaction (qRT) assay for PE melanoma-draining SLNs.
The SLN sections (n = 214) were assessed by qRT assay for 4 established messenger RNA biomarkers: MART-1, MAGE-A3, GalNAc-T, and PAX3.
The qRT assay upstaged 48 of 161 histopathology-negative (hematoxylin-eosin and immunohistochemistry) SLN specimens. At a median follow-up of 11.3 years for the entire cohort, estimated rates of 10-year overall survival (OS) and melanoma-specific survival (MSS) were 82% and 94%, respectively, for histopathology-negative/qRT-negative patients; 56% and 61%, respectively, for histopathology-positive patients; and 52% and 60%, respectively, for histopathology-negative/qRT-positive patients (P < 0.001 for OS, P < 0.001 for MSS). In a multivariate analysis of known melanoma prognostic factors, qRT positivity was significant (P < 0.05) for disease-free survival (hazard ratio [HR], 4.3; 95% confidence interval (CI), 2.3–7.8), distant disease-free survival (HR, 6.6; 95% CI, 2.9–14.6), MSS (HR, 6.2; 95% CI, 2.6–14.4), and OS (HR, 2.8; 95% CI, 1.6–4.9).
The multimarker qRT assay has prognostic significance for molecular upstaging of PE melanoma-draining SLNs. Molecular upstaging of histopathology-negative SLNs confers a prognosis similar to that associated with SLN micrometastasis, and the number of positive qRT biomarkers is correlated to disease outcome.
The undisputed prognostic significance of lymph node involvement in melanoma1,2 led to the development of sentinel lymphadenectomy (SLND), pioneered by our group.3 This minimally invasive technique selectively samples the first nodes on the most likely path of lymphatic spread from a primary cutaneous melanoma.4,5 Excised sentinel lymph nodes (SLNs) are subjected to pathologic ultrastaging, during which multiple fine sections of each SLN are examined by both hematoxylin and eosin (H&E) and melanoma-specific immunohistochemistry (IHC).4 The SLND is generally considered the standard of care for the staging of clinically localized melanoma,6,7 and management based on SLND can affect clinical outcome.8
However, current histopathologic analysis of the SLN has limitations. The IHC staining of serial sections from the SLN can detect metastases missed by standard H&E staining of bivalved sections, but it still has a 15% to 25% rate of false negatives because of sampling error.9 Moreover, melanoma will recur in up to 30% of patients who have no histopathologic evidence of tumor in the SLN specimen.10–12
For the last decade, our group has been developing and improving quantitative molecular techniques to complement and supplement histopathologic assessment of the SLN. In 2004, we reported that the detection of tumor-related messenger RNA (mRNA) by quantitative real-time reverse transcriptase–polymerase chain reaction (qRT) assay of paraffin-embedded (PE) SLNs can identify clinically relevant metastases that are missed by histopathology.13 In the present study, we report 10-year follow-up data and further analysis for the same cohort, with particular attention to patients with histopathology-negative SLNs. This is the first longitudinal study of survival based on qRT detection of PE SLN metastasis, and the first long-term data to confirm the prognostic significance of histopathology-negative, qRT-positive SLNs in patients with clinically localized melanoma.
As described in our initial report,13 PE SLN tissue was obtained from consecutive patients undergoing surgery for early-stage, clinically localized melanoma at the John Wayne Cancer Institute between March 1992 and December 1999. Clinicopathologic data collected for this study included patient sex and age, American Joint Committee on Cancer stage of melanoma at presentation, and primary tumor characteristics (anatomic site, Clark level, Breslow thickness, and ulceration status). Of the 281 patients who underwent SLND for primary melanoma during the study period, 226 patients were eligible for inclusion on the basis of the availability of PE blocks, long-term follow-up, signed informed consent, and IHC analysis. The final selection of patients was performed by database management personnel, in a manner independent of the investigators and biostatisticians, as previously described.13 Informed human subjects/institutional review board consent was received for the use of all specimens in this study.
All patients with early-stage, clinically node-negative cutaneous melanoma underwent preoperative lymphoscintigraphy to identify the draining lymph node basin. After intraoperative mapping of the SLNs with isosulfan blue dye (Lymphazurin, Hirsch Industries Inc, Richmond, Va) and radioisotope (99m technetium sulfur colloid), SLND was performed.3–5 Complete lymph node dissection (CLND) of the regional basin was performed if SLN metastasis was detected by histopathology.14 Patients with histopathology-negative, qRT-positive SLNs did not undergo CLND.
Patients were observed by conducting serial clinical and diagnostic examinations. Melanoma recurrences were treated with surgery and/or best available medical therapy. All patient data were recorded in the John Wayne Cancer Institute melanoma database under the control of the database coordinator.
After a portion of each SLN was removed for frozen-section evaluation, the remaining bisected node was formalin-fixed and was PE. For histopathologic analysis, 4-μm sections were cut from each PE block at 2 different levels separated by 40 μm, according to our standard technique in the early-SLN era. Each section was stained with H&E and antibodies to HMB-45, MART-1 and/or S-100P.4,14
For molecular analysis, 10 serial sections (each 10 μmin thickness) were cut from the remaining SLN.15 Sections were cut with a new sterile microtome blade, deparaffinized, and digested with proteinase K before extraction of RNA with a modified protocol for the Paraffin Block RNA Isolation Kit (Ambion, Austin, TX), as previously described.15 RNA was quantified by ultraviolet photospectrometry and RiboGreen assay (Invitrogen, Carlsbad, CA). Eleven patients with poor quality, undetectable RNA from PE SLNs were excluded from the study.13
Primer and probe sequences were designed as previously described.16 Assays were optimized by using PE primary and metastatic melanomas, PE histopathology-negative lymph nodes, and metastatic melanoma cell lines as controls, with GAPDH expression as an internal reference for mRNA integrity. Polymerase chain reaction (PCR) conditions and annealing temperatures for each biomarker were assessed by receiver operating characteristic curve analysis.13 These initial studies used an independent set of 71 PE nodal tissues from 71 patients; 39 histopathology-verified tumor-negative lymphoid tissues from patients with breast cancer and benign disease, and 32 histopathology-verified metastatic melanomas.13 Comparisons were made of PE SLN with frozen SLN to validate equivalent qRT efficiency on both specimen types.
All assays incorporated positive controls (established melanoma lines, PE metastatic melanomas), negative controls (normal or tumor-free lymph nodes), and reagent controls (reagents without complementary DNA or RNA). Each assay was performed in triplicate for verification and the mean copy number was used for analysis. The mRNA copy number was calculated using Real-Time Detection Software.13
The t test was used for continuous variables and the χ2 test was used for categorical variables. Kappa analysis and Spearman correlation coefficient analysis were used to compare mRNA copy numbers. Overall qRT positivity was defined by at least 1 positive biomarker. Cox proportional hazard (Cox-PH) models were used for multivariate analysis. Backward stepwise model-selection procedures were used to find the optimal set of predictors for overall survival (OS), melanoma-specific survival (MSS), disease-free survival (DFS), and distant DFS (DDFS). These clinical end points were measured from the time of SLND. Recurrence was defined as either distant or locoregional. The cumulative survival rates for patient groups were calculated by using Kaplan-Meier methods. The subject categories based on SLN status were compared with the log-rank test. For the histopathology-negative SLN subjects, Cox-PH models were constructed for each clinical end point by using Breslow thickness and ulceration of the primary melanoma and individual and overall qRT biomarker status of the SLN. All P values were assessed as 2-sided and were significant at 0.05.
The study cohort comprised 214 patients: 126 men and 88 women, with a mean age of 50.9 years.13 Melanomas were located primarily on the extremity, followed by the trunk and then head and neck. Ulceration was present in 39 (19%) of 208 primary lesions (ulceration values were missing for 6 subjects).
The SLN specimens were histopathology positive in 53 patients and qRT positive in 47 (89%) of these 53 patients. The SLN specimens were histopathology negative in 161 patients and qRT positive in 48 (30%) of these 161 patients. Mean thickness of the primary melanoma was 2.9 mm versus 1.9 mm for patients with histopathology-positive versus histopathology-negative SLNs (P < 0.001) and 1.9 mm versus 2.0 mm for patients with qRT-positive versus qRT-negative SLNs (not significant). Of the 208 patients with known ulceration status, 156 had histopathology-negative SLN specimens, 25 (16%) of which were associated with ulcerated primary melanomas.
During an overall median follow-up of 11.3 years, melanoma recurred in 76 (36%) patients: 28 (53%) of 53 patients with histopathology-positive SLNs and 48 (30%) of 161 patients with histopathology-negative SLNs. The median time to recurrence at any site was 72.5 months for patients with histopathology-positive SLNs, 63.3 months for patients with histopathology-negative/qRT-positive SLNs, and not available (too few events) for patients with histopathology-negative/qRT-negative SLNs; corresponding means were 73, 63, and 144 months, respectively. Of the 48 patients who had histopathology-negative SLNs and recurrence, 27 (56%) had qRT-positive SLNs. Four (8%) recurrences in the histopathology-positive group were associated with qRT-negative SLNs. The median number of positive qRT biomarkers was greater in the recurrence group (1 vs 0) (Table 1).
Recurrence was significantly associated with Breslow thickness (mean ± standard deviation of 2.3 ± 2.0 mm in the recurrence group vs 1.8 ± 1.7 mm in the no-recurrence group; P = 0.03) but not with Clark level. Of the 156 patients who had histopathology-negative SLNs and known ulceration data, 9 (20%) of 44 with recurrence had an ulcerated primary-melanoma, compared with 16 (14%) of 112 with no recurrence. However, ulceration was not significantly associated with DFS.
Table 2 shows the correlation between first observed site of recurrence and tumor status of the SLN specimen. Rates of locoregional and distant recurrence were similar between patients with histopathology-negative/qRT-positive SLNs and patients with histopathology-positive SLNs. In patients with histopathology-negative SLNs, the likelihood of locoregional and distant recurrence increased with the number of positive qRT biomarkers (Table 1). No individual biomarker correlated with first recurrence at a distant versus a locoregional site. Twenty-one (10%) patients with recurrence had SLNs that were negative by histopathology and qRT. Of these 21 recurrences, 13 (62%) were locoregional and 8 (38%) were distant. Two distant recurrences occurred in the brain; other first sites of distant recurrence were lung, vertebra, pancreas, adrenal gland, rectum, and an unspecified site.
Estimated 10-year OS rate was 82.3% for patients with histopathology-negative/qRT-negative SLNs, 56% for patients with histopathology-positive SLNs, and 51.9% for patients with histopathology-negative/qRT-positive SLNs (Fig. 1A). Similarly, estimated 10-year MSS rate was 93.5% for patients with histopathology-negative/qRT-negative SLNs, 60.8% for patients with histopathology-positive SLNs, and 60.4% for patients with histopathology-negative/qRT-positive SLNs (Fig. 1B). Although OS and MSS differences across all 3 groups reached significance (P < 0.001), differences between histopathology-positive and histopathology-negative/qRT-positive groups were not significant. As the number of positive qRT biomarkers increased, OS and MSS decreased (P < 0.001) (Figs. 1C, D).
The same trends were found in recurrence patterns. Estimated 10-year DFS rate was 83.6% for patients with histopathology-negative/qRT-negative SLNs, 48.1% for patients with histopathology-positive SLNs, and 44% for patients with histopathology-negative/qRT-positive SLNs (Fig. 2A). Similarly, estimated 10-year DDFS rate was 93.6% for patients with histopathology-negative/qRT-negative SLNs, 67.2% for patients with histopathology-positive SLNs, and 56.5% for patients with histopathology-negative/qRT-positive SLNs (Fig. 2B). Although DFS and DDFS differences across all 3 groups reached significance (P < 0.001), differences between histopathology-positive and histopathology-negative/qRT-positive groups were not significant. As the number of positive qRT biomarkers increased, DFS and DDFS decreased (P < 0.001) (Figs. 2C, D).
A Cox-PH model was used to evaluate the correlation of standard prognostic factors, rate of recurrence, and OS in patients with SLNs positive for 1 or more qRT biomarkers. Hazard ratio was calculated for each individual biomarker and for overall qRT positivity. As shown by the hazard ratios in Table 3, qRT positivity was a strong prognostic factor for DFS (P < 0.05), DDFS (P < 0.05), MSS (P < 0.05), and OS (P < 0.05). Among individual biomarkers, GalNAc-T positivity had the strongest correlation with DFS (P < 0.05) and MAGE-A3 positivity had the strongest correlation with DDFS (P < 0.05). MART-1 positivity had the strongest correlation with OS (P < 0.001) and MSS (P < 0.001).
In a recently reported collaborative blinded study with the Sydney Cancer Centre, we confirmed that qRT assay could identify occult metastasis in SLNs that were negative by initial histopathology: qRT assessment of 74 archived PE SLNs from 33 patients upstaged melanoma in 4 patients (12%).10 That study also found that although both conventional histopathologic assessment and qRT assay depend on accurate surgical and nuclear medicine techniques, qRT assessment of SLN sections has greater sensitivity. But do qRT-detected tumor cells have clinical relevance?
In this long-term follow-up study, we demonstrate that patients with qRT-positive SLNs had significantly worse OS, MSS, DFS, and DDFS than patients with histopathology-negative/qRT-negative SLNs. Since our 2004 report of this cohort, the OS and DDFS curves for qRT-positive and histopathology-positive patients have separated: by about 7 years, qRT-positive patients had a worse OS; by about 8 years, they also had a worse DDFS. Interestingly, the pattern of recurrence associated with histopathology-negative/qRT-positive SLNs was comparable with the pattern of recurrence that we previously reported for patients with a falsely negative SLN.17
Although our findings suggest that molecular detection of melanoma metastasis in the SLN predicts an increased risk of distant as well as locoregional recurrence, they must be qualified by the reminder that all patients with histopathology-positive SLNs underwent immediate CLND, whereas patients with histopathology-negative/qRT-positive SLNs received treatment only for recurrence. Prospective analysis of the prognostic significance of qRT-positive SLNs is underway in the second Multicenter Selective Lymphadenectomy Trial. This randomized international phase III trial is the first study to stratify patients for treatment (CLND or nodal ultrasono-graphic observation) on the basis of the molecular status of the SLN specimen. Results not only will determine whether CLND is necessary in all patients with SLN involvement, but also will establish the clinical utility of nodal upstaging on the basis of detection of molecular biomarkers.
The qRT biomarker panel that was used in this study is currently being applied in second Multicenter Selective Lymphadenectomy Trial. The panel comprises comprised biomarkers with a high level of clinical utility for disease outcome in melanoma patients. This selection criterion eliminated tyrosinase and gp100, because these 2 well-known proteins of the melanogenesis pathway14,18–20 have unacceptably high false-positive rates in the regional lymph nodes.21–23 Of the 4 biomarkers used in this study, MART1 is a melanoma-associated antigen commonly expressed by melanomas but absent in nonmelanoma malignancies and normal non-cancer lymph nodes13,20,24 Likewise, MAGE-A3 is a melanoma-associated antigen not produced in normal tissues except male germline cells and placenta.25 GalNAc-T, PAX3, and MAGE-A3 are not detected in nevi or differentiated melanocytes. Importantly, these biomarkers are from nonoverlapping malignant pathways.13,18,23,26–28 For example, GalNAc-T, a key enzyme for biosynthesis of tumor-associated gangliosides GM2 and GD2,29,30 is a biomarker for aggressive melanoma progression, as shown previously by our group.31 PAX3 a transcription factor involved in melanoma proliferation and is resistance to apoptosis, migration, melanogenesis regulation, and differentiation.32,33 PAX3 is activated during fetal-tissue development; it is suggested to block terminal differentiation and thereby maintain the stem cell function of melanoblasts.34,35 PAX3 expression was a significant hazard for disease recurrence in this study (Table 1).
Several large studies have found no link between molecular biomarkers and prognosis in patients with clinically localized melanoma.24,25,36 The Sunbelt Melanoma Trial, a multicenter prospective randomized study of melanoma staging and adjuvant therapy, reported no difference in DFS, DDFS, or OS between reverse transcriptase-PCR (RT-PCR)–positive and -negative patients followed up for a median of 30 months.37 However, this trial included TYR as a weighted molecular biomarker for positivity; also, it used a nonquantitative gel-based assay, and it did not standardize SLN pathology sampling. Both histopathology- and RT-PCR–positive patients were randomized to different adjuvant treatment arms with α-interferon, which would have diluted differences in outcomes. In an unusual result, Hilari et al21 recently reported low specificity for any melanoma biomarker (TYR, MART1, SSX2, MAGE-A3, PAX3, GalNAc-T, PLAB, and L1CAM) and no association with disease recurrence. However, significant low recurrence rates and a high percentage of thin melanomas in that study would have biased its interpretation. Several of the biomarkers used have been shown to be of clinical utility by our group and other groups.21
A recent meta-analysis review by Mocellin et al23 examined 22 large studies of PCR upstaging of the SLN. Three of the studies used quantitative RT-PCR assays; most of the remaining studies used standard or nested gel-based RT-PCR. These traditional RT-PCR assays have limited sensitivity. Only 12 studies included at least 2 biomarkers in the RT-PCR analysis, and 11 of the 12 studies used tyrosinase. The heterogeneity of technique complicated the analysis but did not prevent some useful conclusions about RT-PCR as a prognostic factor. Overall, the RT-PCR positivity rate of 51.1% was significantly higher than the histopathology positivity rate of 20.3%, a finding that is in agreement with the data presented in our current report. The RT-PCR was positive in 42.3% of histopathology-negative SLNs, and the false-negative rate for RT-PCR was only 4.9%. The disease-recurrence rate was significantly higher when RT-PCR results were positive versus negative (16.8% vs 8.7%). A negative predictive value of 91.3% indicates a useful prognostic factor. These data suggest that molecular staging of the SLN yields valuable, informative prognostic findings despite variability in molecular assays used.
The data presented in this report are limited by the era in which the PE specimens were generated (1992–1999), as would be the case for any study of long-term outcomes based on retrospective analysis of specimens. Since the introduction of SLND for melanoma in 1992,3 histologic evaluation of the SLN has become more efficient and more detailed in some centers.4 Use of the current standard of SLN ultra-staging may have increased the yield of histopathology-positive SLNs in our study, decreasing the number of histopathology-negative/qRT-positive SLNs and influencing the survival curves. However, it would not have decreased the number of qRT-positive SLNs and likely would not alter the results of the multivariate analysis. As recently reported by our group, the multiple disciplines involved in SLN detection and staging increase the potential for variations and errors but do not diminish the ability of molecular staging to detect occult micrometastases missed by conventional techniques.10
Another consideration is the evolution of melanoma staging, which has become more accurate and sophisticated in recent years. The presence of ulceration may predict a higher likelihood of recurrence even when the SLN is histologically negative. Thus, our study's inclusion of ulcerated lesions may account for its high rate of recurrence; the 30% recurrence rate is higher than expected at 10 years of follow-up. However, the 19% ulceration rate is in line with previously reported rates of ulceration for primary-tumor depths of 1 to 2 mm.38 Again, changes in state-of-the-art diagnosis and treatment are inevitable limitations faced by any longitudinal prognostic biomarker study.
Our study of molecular upstaging for histopathology-negative SLNs from American Joint Committee on Cancer stage I/II patients has the longest follow-up for molecular staging of regional lymph nodes in any solid cancer. The study is also the first to demonstrate the significant prognostic utility of molecular upstaging on the basis of PE tissues. The data confirm a prognostic role for multimarker qRT assessment of SLN PE tissue from patients with clinically localized melanoma and support molecular analysis as part of the comprehensive prognostic assessment.
This work was supported by the Samueli Foundation Fellowship (MBN), the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, Ruth and Martin H. Weil Fund, as well as Award Number P0 CA029605 and P0 CA012582 from the National Institutes of Health and National Cancer Institute. The content is solely the responsibility of the authors and does not necessarily represent the official view of the National Cancer Institute or the National Institutes of Health.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Slice the bread into 12 thin slices without end crusts. Spread 1 tablespoon chocolate hazelnut spread between 2 slices of bread making 6 sandwiches. The crusts will be cut off so you don't need to cover the bread completely.
Using a large drinking glass, cut a circle out of the middle of each sandwich. This will also seal the edges of the sandwich.
Combine beaten eggs, milk, sugar, orange juice, melted butter, vanilla and salt. Heat frying pan to medium heat and spray with non-stick spray. Dip sandwiches in the batter, coating both sides and cook on both sides until nicely browned.


text: This graduate textbook outlines an approach to working with children and teens within the family counseling context, walks through each stage in the therapy process, and reviews the characteristics and treatment options for mood disorders, externalizing disorders, and developmental disorders. A supplemental workbook is also available. Annotation ©2004 Book News, Inc., Portland, OR


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Website Description
The Doctor Who Fanzine Preservation Project Collection is administered by the Earthbound TimeLords, academic Doctor Who research organization. The DW-FPP Collection is a non-lending library created for the use of academic and serious researchers, authors, and historians. The project exists to help researchers check references, get articles, or find supporting evidence for their own works. The Earthbound TimeLord staff will in most cases research the materials for you, and can in some cases provide photocopies or scans of research materials. Researchers who may wish to examine the actual materials can often make arrangements to do so by contacting the Earthbound TimeLords.
Questions related to the research of a particular fanzine or resource should be directed to Nick Seidler, the primary curator of this project, who can be contacted at firstname.lastname@example.com. The secondary curator of this project is John Curtis, who can be contacted at firstname.lastname@example.com.


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Our Ambassadors
"Meet the Alinker Brand Ambassadors..."
We are thrilled to introduce the ability inclusion champions who have accepted the Alinker Brand Ambassador role for various regions of the world. These are outstanding individuals who are now leading our Innovation for Inclusion mission, inspiring people through their exceptional work, thus helping build the inclusive community we have envisioned.
"When I first saw the Alinker, it was the racecar yellow color that caught my attention, followed by my thought that it looked like no mobility device I had ever seen.
Before I was sold on the idea of the Alinker, I was sold on Barbara's vision. I was taken aback by the stories of the people helped by the device and simultaneously, I started thinking about people I could reach out to who would love to give it a try and who would benefit from it greatly.
Of course, being a bilateral below knee amputee, I didn't think it would be useful to me. And then I sat on it and gave it a try. I realized that Barbara and Leon, made it look easy. I also realized that after so many years, I finally felt my hamstrings really work. Suffice it to say that after 15 minutes, my legs were burning, and I knew I wanted one.
For many, the Alinker is about giving people with mobility challenges the freedom to stay or become active again. To some, It's about not accepting the norm, and challenging the status quo. And to others, It's about creativity and innovation with a social conscience. But for me, it's a device to help me on the road to achieving my goal of living a healthy and independent life. For all these reasons and many more, I am so glad I found the Alinker." — Felicia Voss-Shafiq SAP Senior Support Engineer, Canadian Paralympian.
Alinker Brand Ambassador Canada.
"Being an Alinker Ambassador for The United States will allow me to introduce an alternative to amputees. The comfortability and design of the Alinker make it easy for me to walk while exercising my leg. I'm looking forward to creating positive influence and impact with the brand."
I was introduced to the Alinker at my Bezgraniz Couture fashion show at L.A. fashion Week in October 2016. I didn't think I would be able to ride a bike since I only have one leg. The Alinker's design allows me to move around with ease and comfort. Who would I recommend the Alinker to? Anyone looking for a non-traditional bike alternative whether you're an amputee, elderly person, or anyone who needs to build more circulation in their legs.
Being an amputee has its challenges. I never thought I would be able to ride a bike again after losing my leg to bone cancer. The Alinker changed my life! I now travel around my neighborhood with ease and comfort when I need to run a quick errand. I can now keep up with my friends & family. YES!" — Jerris Madison (44) Los Angeles, California, USA Photographer. Influencer. Editor in Chief of OBVIOUS Magazine.
#250KChallenge Competitor.
Alinker Brand Ambassador for North America.
"Hoorah, for LinkedIn! That's how I was introduced to Barbara Alink and the Alinker just some months ago. Upon its arrival, I looked forward to unpacking and assembling my very own; all but 10-15 minutes of it, I was thrilled to test it out and realized how forward thinking the concept was.
I began to think of all the ways this could enhance, encourage and entice others to connect with the outdoors thus creating a connection to mind, body, soul and spirit. A few things that are crucial and necessary in any form of rehabilitation or conscious movement.
So far, every time I take it for a spin I'm immediately approached or asked details about the concept behind it. I so wish the Alinker would have been available some nine years ago when I was on crutches, my experience would have been so different.
Now as a new Brand Ambassador for Alinker, I'm empowered to mentor, inspire, motivate other fellow veterans, active older adults, anyone experiencing challenges to have a choice or alternative in how they move their bodies, one step at a time." — Laura Ortiz (47), Miami, Florida, USA Recreation Specialist for Miami Dade Parks, Recreation and Open Spaces. Veteran. Adaptive Athlete. Track Paralympian. Paratriathlete. Peer Specialist. Outreach Yoga Instructor. Fitness Instructor.
Alinker Brand Ambassador for North America.
"I am an ability crusader, a blogger, a model and a designer. I'm passionate about universal design and inclusion. I live with a spinal cord injury and use a cane and manual wheelchair for mobility every day.
I am currently working on my walking canes, have an inclusive dance class, am an ambassador for an inclusive media organization, am involved with Spinal Cord Injuries Australia, and on the Access committee for my local council... I have several other things in the works BUT I always have time for more.
My passion for universal design and inclusion developed out of necessity. When a spinal cord stroke left me with incomplete paralysis, I suddenly found myself in an environment and a society that were no longer built for me. After years of exerting energy on trying to adapt, I decided to educate the world on my needs and wants with the hope that maybe something would change.
My first encounter with the Alinker was in Los Angeles at LA Fashion Week. I was modeling for Bezgraniz Couture, an inclusive fashion label, and the Alinker was featured during their show. From the moment I saw it I was hooked. To me, this product is the epitome of purposeful design and universal thinking. — Angel Dixon (Port Macquarie, Australia) Alinker Brand Ambassador Australia.


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Jan 10, 2012 Russ Tarby Uncategorized
Is there anything quite as satisfying as being able to say "I told you so"? I don't think so.
In my Dec. 28 Livin' in Liverpool column for the Eagle Star-Review I wrote, "You're a jerk if you go to First Night." The Dec. 31 bash at Onondaga Lake Park was headlined by New Boyz, a couple rappers from SoCal who muddied up the celebration with putrid patter, misguided misogyny and obscene gestures. The Boyz specialize in a new dance style called "jerkin."
All this at an event heavily hyped as "family-friendly."
After all, booze was banned!
But cocktails are civilized compared to the litany of four-letter words pouring from the speakers when these 20-year-old "pop stars" took the stage. In fact, they're so immature that they refused to tone down their explicit performance even after First Night producers from Galaxy Communications politely asked them to keep it clean.
Crawling out of the Mojave Desert town of Hesperia, Calif., the New Boyz are two 20-year-olds named Earl "Ben J" Benjamin and Dominic "Legacy" Thomas. In 2009, the duo scored its first hit with a track titled "You're a Jerk."
'Absolutely appalling'
Visitor Brenda Newkirk was shocked by the group's "absolutely appalling vulgarity." Newkirk — who drove her family from Weedsport and paid the First Night adult ticket price of $8 each — deduced that Ben J and Legacy "have no self-respect, nor respect for anyone else." Well said.
Since New Year's Day, Galaxy and sponsors AmeriCU Credit Union and Burdick Family of Dealerships at Driver's Village have all been busy wiping egg from their faces. And the yolk's on Onondaga County Parks & Recreation, where the outrage was staged.
Before booking the New Boyz, "family-friendly" First Night organizers should've had second thoughts about performers whose hits include titles like "Tie Me Down," "Backseat" and "Better with the Lights Off."
'Soundcheck' silenced
Controversy hit Galaxy Communications like a ton of bricks last week. First the First Night flap, then they heard complaints galore after firing longtime disc jockey Dave Frisina. The entire local music community is bemoaning the loss of one of its few friends in the Syracuse radio market. Since 1979, Frisina has hosted "Soundcheck," a Sunday-night radio show featuring the artistry of local musicians. If there's any justice in the music world, "Soundcheck" will soon find a new home.
Dana & Carl on air 20 years
Radio listeners still seeking the sounds of Syracuse should tune in via computer at westcottradio.org, from 9 p.m. to midnight Sunday, Jan. 15, for a commemorative show called "We're Your Friends For Now: 20 Years Of Dana & Carl" hosted by power pop fanatics Dana Bonn and Carl Cafarelli.
Dana and Carl regularly host "This Is Rock'n'Roll Radio" which just began its 14th year as the little mutant radio show that could. Before that the determined duo spun discs for WMNA, WXXE and helped to establish Syracuse Community Radio.
"We specialized in theme shows," Cafarelli said. "British Invasion, Beatles Rarities, The Monkees, Rock'n'Roll Soundtracks, 45s Only, The Sounds Of Summer — with sporadic themeless shows too."
Mighty oysters at bc
After two weeks of minor renovations, one of the anchor restaurants in Armory Square — bc, at 247 West Fayette St. — will reopen at 5 p.m. Friday, Jan. 13. I'll be there to order up a plate of Island Creek Oysters from Duxbury Bay in Massachusetts. And I'll gladly nibble on the complimentary small bites they'll serve in the bar all night.
The chef at bc, Wayne Cafariella, creates high-quality meals for reasonable prices. His idea of modern dining is that "You can go out and have a four-star meal in jeans and T-shirt and not break the bank."
The downtown eatery and bar is celebrating its eighth year with a more casual approach under the guidance of managing partner Ellen Leahy and general manager Shaun Preble, who are both committed to reviving downtown.
"We like to go out and eat delicious fresh food, but we also want to feel relaxed and let our hair down," Leahy said. Me too.
Check out bcrestaurant.com; 701-0636.
'Soft and White'
Syracuse poet Elinor Cramer has a new collection out. It's called "She Is a Pupa, Soft and White," published by Cincinnati's Word Press. Downtown readers will especially appreciate the long-titled poem, "Canal Walls Engineered So Carefully They Still Hold Water," which is a paean to the Erie Canal Museum on Water Street.
Written in a conversational prose style without difficult meters and sing-song rhymes, Cramer's poems also pay tribute to our area with "The Crows of Auburn" and seasonal verses such as "Walking on Snow."
Cramer will read her poetry at 7 p.m. Jan. 20, at the Downtown Writers' Center at the YMCA on Montgomery Street. Jessica Cuello, author of the chapbook "Curie," will also read that evening.
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Kenzie Green – Jesse Loads Monster Facials
Released: December 1, 2016
Blonde, Blowjob, Clips, HD, Teens
Kenzie is a playful curvaceous cockslut with rock star hair and groupie gaze. She shows off her juicy ass with a wild twerking show as she sizes up Alex's cock before wrapping her mouth around it like a starved anaconda. She gets her face fucked until her messed up makeup is coated with creamy cum.
Do you like this video?


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The latest monthly breakdown from PIMCO's Total Return Fund is out. Among the key findings for June are that the total AUM declined modestly by $400 million to $242.8 billion, well below the all time highs of $256 billion in October 2010. More notably, it appears that Gross has gotten tired of being mocked by CNBC for his Treasury short position and has raised his cash Treasury bond exposure by 3% to 8%, though even with that move he is still net neutral courtesy of a 1% Agency cash position and -9% in synthetic swap exposure, unchanged from May. Therefore Gross is no longer short on a net basis. He also reduced his IG exposure from 18% to 17%, offsetting an increase in emerging market corp bonds by 1%. Where he did however invest quite a bit of money in are Non-US Developed market: i.e. European sovereigns: arguably Italian names, as per the announcement of PIMCO's Bosomworth on Bloomberg TV last night. However, since this report is for June, and since the increase in bond exposure occurred before the massive rout in July, it probably means that Gross did not time his increase in European debt exposure quite as well as he had hoped. Lastly, and just as interesting, is the increase in the effective duration of the TRF, which rose from 3.73 to 4.37, the second highest in 2011, and a steep rise from the near record low 3.42 in April. At least Gross can now saw that he is no longer largely underweight duration. Lastly, the fund still has gobs of cash, at just over $70 billion.
PIMCO Raises Combined Cash-Synthetic Treasury Position To Zero, Buys European Bonds
- Printer-friendly version
- Jul 12, 2011 5:22 PM
- 27
PIMCO could crush CRIMEX silver in a split second by saying "I'll have the remaining 28MN oz".
Chasing yield again?
$7 billion in cash or $70 billion?
7bln is 3% of the fund, I don't think they have 30% in cash...still it's a lot of cash, imagine how much gold u could buy
I want to invest in China. High quality.
New road collapses after 2 days. Excuse me, 1 1/2 days. Love those guard rails.
this looks just like the road those three government officials were inspecting!
I'm sure glad that the steel sections for the new span of the Bay Bridge were made in China. Luckily, the Bay area is not a seismically active zone.
Nor any asians there either.
And 32 times -27 does fucking equal -864.
So no more comments about bad math (stuff like Greece's or Spain's debt, US debt ceiling, etc.) from the paenut gallery cheerleading section. Buggers.
That's ok, it'll be inspected.
Just like the bridge/road/train station/train/water/food/milk/whatthefuckever in China, but just remember, now it's being done right, by a bunch of mysogynist public employee members of the SEIU who cannot be terminated for cause, who, around SanFran might even like to take one of those big steel bolts and stick it in their bungs, write the report as "la de dah" and when the bridge collapses during the next magnitude 8.9, caused whole or in part by the magical HAARP machine trying to wipe the entire evil gay population off the map when Michelle Bachman is president, then they can blame it on the Godless Chinks when nobody'll get healed through prayer and positive thinking.
We are in Good Hands, with The State
(picture of TSA agent squeezing boy's glotz)
Henry Kissinger celebrates Red Day a few weeks ago with his Commie friends. Says Mao is great (@2:10)
Chinese propaganda with rap "good men join the army". "mao is tha man" got millions of views in China.
O my sweet beef, I must still be good angel to thee. The money is paid back again.
Gross getting whipsawed just like cta's and hedge funds - no asset class works in a high correlation world.
No asset class saves a manager from bad decisions.
Was it Timmah told him it was "a good idea" at the time? Fishin' for the new job?
"Don't worry we're there. Already on top of it. Benji's a printin' like there's no manyana."
(giggle, giggle, snort, snort)
Relax, we are all getting a bailout from Comet Elenin this October.
If that's the case, then bugger off and tend to more important things than these. If I thought the end of the world was this October, I wouldn't be wasting time here.
Depending on where you read, approach is 9/10 at 0.45 AU or 9/25 at 0.20 AU. The moon is .0024 AU "close". Do the math
Close enough for Gubamint work.
Maybe pimco is the u.s. Q.E. to the world since we started this mess. I mean how many other financial gurus are out there criticizing the us treasuries and getting air time out the butt? Geitner says float italy some money.. some money gets floated.... all out war if u.s. does not pay back... eu
I knew it was only a matter of time before PIMCO got itchy and figured it better "put some money to work" by chasing some crappy asset like PIIGS bonds.
Like I said earlier, the yields are getting high enough to entice some funds with some bravado to go in and brag about how they "loaded up" at or near the low tick, and now they will be able to luxuriate in high yields for years to come.
Now Gross is figuring out what else to do with his money. Probably end up buying high yield stocks or something.
sure beats pounding the table publicly on shorting treasuries. the headline is still priceless though: "Muhammed says short US treasuries!" would it be any other way? now let us look peerlessly into the sophisticated trading strategies being employed by today's financial "MASTERS OF THE UNIVERSE"
Beware==pretty sure Pimco/Gross were among the list of creditors that were caught pants down with Lehman paper as they entered bankruptcy protection.
I'll take "Notable Bankruptcies" for a Trillion, Alex.
Yes indeed. Link
Stupid billy boy, why are you investing in juncky souvereign bonds when you have AAA US treasuries? Are you reading any Moody's reports?
so he just loaded up on WOP debt ?
He has timing issues.
PIMCO may have been told to cut it out by TPTB and start buying treasuries again.


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"Hermione just stole all of our shit."
Emma Charlotte Duerre Watson (born April 15, 1990) is a French-born British actress, best known for playing Hermione Granger in the Harry Potter movies. She is following up the Potter series with a small role in My Week With Marilyn, the Princess Pea in The Tale of Despereaux and the female lead in The Perks of Being a Wallflower. She acted in Sofia Coppola's The Bling Ring and in Darren Aronofsky's 2014 Biblical epic film, Noah. She was tapped to play Beauty in a Guillermo del Toro version of Beauty and the Beast. The project fell through and she has now been cast instead as Belle in the 2017 live-action adaptation of Disney's Beauty and the Beast.As of July 2014, she is also a Goodwill Ambassador for the United Nations Entity for Gender Equality and the Empowerment of Women, campaigning for womens' rights and gender equality.Not to be confused with Emily Watson or Emma Thompson, both of whom are old enough to be her mother (but aren't, just so we're clear).
Selected filmography:
- Harry Potter series (20012011) as Hermione Granger:
- Harry Potter and the Philosopher's Stone (2001)
- Harry Potter and the Chamber of Secrets (2002)
- Harry Potter and the Prisoner of Azkaban (2004)
- Harry Potter and the Goblet of Fire (2005)
- Harry Potter and the Order of the Phoenix (2007)
- Harry Potter and the Half-Blood Prince (2009)
- Harry Potter and the Deathly Hallows — Part One (2010)
- Harry Potter and the Deathly Hallows — Part Two (2011)
- The Tale of Despereaux (2008) as Princess Pea
- My Week With Marilyn (2011) as Lucy
- The Perks of Being a Wallflower (2012) as Sam
- This Is the End (2013) as herself
- The Bling Ring (2013) as Nicki Moore
- Noah (2014) as Ila
- La Colonia (2016) as Lena
- Beauty and the Beast (2017) as Belle
- The Circle (2017) as Mae Holland
Tropes that apply to this actor include:
- Character Tics:
- Her infamous "eyebrow acting".
- Mouthing her costars' lines.
- Covered in Gunge: She and Rupert Grint had this happen to them (she got it worse) live on American TV.
- Fascinating Eyebrow: Her eyebrows can act, even over-act, by themselves.
- Important Haircut: As soon as the Harry Potter films wrapped up, she cut her hair into a pixie (as she had to keep it long for the entire eleven years the series was in production). She kept it short for The Perks of Being A Wallflower and wore wigs and extensions for Noah and The Bling Ring before ultimately growing it long again.
- Kindhearted Cat Lover: Owns two cats.
- Large Ham: At first, but she's gotten more nuanced by now.