text:
MIL did it!
So, my DH is an identical twin, so I decided to sit MIL down and grill her about being pregnant with twins and having twins. I already knew that she didn't have a c-section, but I wanted all the other dirt. And she told me that, among other things, she had a totally natural birth! I knew she had done natural with her other three kids, but wasn't sure if she had with the twins.
It just reassures me that I can have the birth I want anytime I've heard another woman did it. Especially when it's someone I know personally like my MIL.
Re: MIL did it!
That's awesome. What a great support you will have in her.
Re: MIL did it!
that is awesome!!! You can totally do this!
Re: MIL did it!
That's great inspiration and I'm sure she will be good support for you! :)
Re: MIL did it!
Very cool! It is nice to know someone in person who has BTDT!
Re: MIL did it!
Wahoo! Ill be rooting for ya!
Re: MIL did it!
you can do it!!!
Re: MIL did it!
Thanks for the news... I also am expecting twins in Nov DDC and found an OB who delivered twins herself vaginally!!! So excited for my 1st appt!!
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If you would like to know the system of England and for me, please follow any information that information will be in your favor! About the Author Pavel Petkov
понеделник, 27 февруари 2012 г.
Information Jobcentre Plus - London
" Information Jobcentre Plus - London "
For the second time I visited the Bureau of Labour - London National Insurance Number, as before, since my first visit to this office, I made a copy of identity card and (3) signed, but on my next appearance, visited again, the desk, as I like (2) two copies of passport, they still require me (3) signed, even told me to put my signature, which is my passport to be duplicated and it is clear that from me without issue this my National Insurance Number, which means that Bulgaria and Romania are not restrictive, but rather a complete ban, which means it is not possible one of these European countries to work in England, I want to say that this is also one of the policy of this country.
Their excuse is that it will work and these are placed a total ban, while having in mind that England put these bans European Countries ...
All this is done by adding these prohibitions to, for the money of European citizens.
Абонамент за: Коментари за публикацията (Atom)

subset: commoncrawl


text:
At the All-Star break, here are how the Red Sox are trending:
Five promising signs
1. Through his first 44 games, Jacoby Ellsbury had posted a slash line of .241/.303/.335/.638 and had scored 24 runs. Then in his next two games in Chicago, he reached base six times, and has never looked back. In his last 44 games, Ellsbury has posted a slash line of .371/.433/.511, scored 35 runs and stolen 23 bases in 24 attempts. Those are All-Star numbers.
2. It's not humanly possible to play better defensively at second base than Dustin Pedroia. He has handled the most chances, made the fewest errors (1), and has the highest defensive WAR in the majors at his position (1.5). That's what the numbers tell you. The eyes tell you so much more, as barely a night goes by in which Pedroia doesn't make a highlight-worthy play. All at max effort.
3. Since the start of the 2012 season, only one big-league player, reigning AL MVP Miguel Cabrera, has a higher slugging percentage than Sox DH David Ortiz (.631 to .609). Granted, Ortiz missed 71 of the team's last 72 games last season because of a strained Achilles tendon, but he has played just over the equivalent of a full season since the start of 2012, and this is what his line looks like: 163 G, 611 ABs, .318 BA, .409 OBP, .609 SGP, 42 home runs, 48 doubles. Anyone still want to debate the merits of giving Ortiz a two-year extension?
4. John Lackey is getting a higher percentage of swings and misses (9.7 percent) than any season since 2005 (10.6 percent). According to Brooksbaseball.net, the average velocity of his four-seam fastball this July is 93.37 miles an hour, an average velocity he has exceeded in just one month since the start of the 2007 season.
5. Jarrod Saltalamacchia's OPS of .806 (on-base plus slugging percentage) ranks second to Minnesota's Joe Mauer among American League catchers with at least 250 plate appearances.
Five red flags
1. Clay Buchholz has thrown only 11 2/3 innings since May 22. He's supposedly on the road to recovery, but we've heard that before. And there's no telling how the long layoff will impact his performance.
2. Over the last two months (since May 15), first baseman Mike Napoli has the lowest slugging percentage (.380) of any Sox player with at least 40 plate appearances. Napoli, who has 4 home runs since that date, had 7 home runs while slugging .523 in the team's first 39 games.
3. Koji Uehara has been phenomenal for the Sox, but the 38-year-old reliever already has made more appearances and pitched more innings than he did last season for Texas, when he broke down, and is on a pace to finish the season with 69 innings, the most he has thrown since coming from the mainland. Uehara takes great care of himself, but the Sox, who already have been riddled with injuries in the bullpen, could ill afford to lose him.
4. Jose Iglesias wasn't going to hit .400 all season, but he came back to earth hard on this 10-game trip, batting .205 (8 for 39) with 2 walks. All eight hits were singles. Meanwhile, Will Middlebrooks, who began the season as the starting third baseman before being demoted to Pawtucket, homered for the PawSox on Sunday, but is batting .175 (7 for 40) in his last 10 games. Will Ben Cherington borrow a page from one-time mentor Dan Duquette and promote 20-year-old Xander Bogaerts, the way Duquette promoted 20-year old Manny Machado to the Orioles late last season? The Sox will give Iglesias/Middlebrooks time to bounce back first, but it can't be ruled out entirely.
5. In 11 starts since May 20, Jon Lester is 2-6 with a 6.27 ERA. He is learning to rely less on the cutter that made him so dominant earlier in his career, but it remains to be seen whether a greater dependency on his changeup will help restore him to his former preeminence.


text:
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Thomas Docherty MP on Big Ben collapsing
Warning: This post was published more than 5 years ago.
I keep old posts on the site because sometimes it's interesting to read old content. Not everything that is old is bad. Also, I think people might be interested to track how my views have changed over time: for example, how my strident teenage views have mellowed and matured!
But given the age of this post, please bear in mind:
- My views might have changed in the 5 years since I wrote this post.
- This post might use language in ways which I would now consider inappropriate or offensive.
- Factual information might be outdated.
- Links might be broken; embedded material might not appear properly.
Many thanks for your understanding.
The House of Commons authorities would be surprised if the clock tower fell into the Thames any time soon. It may well be raised with the Speaker on Monday. Given that Big Ben is situated over the Speaker's apartments, he may have a view on it.
Thomas Docherty, a Labour MP on the Commons administration committee, according to this Sunday Times article.
This 1,492nd post was filed under: Diary Style Notes, Politics, Quotes, Architecture, Big Ben, London, Parliament, Politics, Thomas Docherty.


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Up with veggies, down with nuggets!
Monday, February 18, 2013
I need to get a handle on how I'm eating. I'm eating portions that are too big, and I'm not eating enough fruits and vegetables. The freggie thing is ridiculous, because I love vegetables. I'm just being lazy about planning my meals and snacks and packing my lunches for work. Part of the problem is that I am not giving myself enough time in the morning to get lunch ready, so there are days when I don't pack anything and end up eating the same lunch my students are having that day (which is generally salty, processed crap. Think chicken nuggets and instant mashed potato. Yuck.) What I need to do is take a few minutes in the evening to pack breakfast and lunch, or at least to plan what I am going to pack.
Goals for this week:
~plan or pack lunch each evening after dinner
~log food at least 2 days this week (I hate logging my food. I cook from my own recipes so much that it is really tedious)
~drink a glass of low-sodium tomato juice every day. I love it and I have a jug in my fridge right this minute, so that's no big chore.
~Make a simple vegetable soup that I can add to my meals this week.
Easy, peasy lemony squeezy. I've got this!
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1730 days ago
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i sometimes make 5 sandwiches on sundays and freeze them . this week i have been makeing two salads at once since i dont go heavy on the dressing it doesnt get to soggy. i love veggies the price has gone up in teh grocery store i need to get the garden going soon
1731 days ago
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Your plan sounds very similar to mine - I pack the lunches (and my breakfast and snacks) for myself and my fiance in the evening after dinner. I'm *terrible* at getting up on time in the morning, I barely have enough time to start the coffee pot and feed the cat so pre packing is just what works. good luck!
1732 days ago
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I am having a much easier time packing my lunch by making a bunch of single serving size portions of fruit on the weekend or when I get them home from the store (little disposable ziplock containers work and do fine in the dishwasher). I take about 5 of them to school with me each day along with a quick salad, some protein, and some crackers. The more you make ahead of time, the easier it is to throw them in an insulated bag and go. I am trying to do it on the weekend because at night, after a long day of teaching, etc., I just don't care to bother. Good Luck!
1732 days ago
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YOU GOT THIS!!! You could also bring a bag of fruit that you like for your desk for the week. If you forget to pack... guess what you will be eating.
1733 days ago
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You can do it! Cut up those freggies as if you were knitting lace!
1733 days ago
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I've been trying to increase my veggies, too. You can eat so much more food for so few calories!! Veggies are so filling!!
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You can do it!
1733 days ago
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sounds like a great plan-you can do it. The planning just makes it easier
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You got it! I know you can handle this. Sometimes it just taking saying it out loud!
1733 days ago
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Hill walking
Glenbeigh Travel Blog› entry 7 of 10 › view all entries
July 29th, 2007 – by: JannyG
We both soaked our feet in a bowl of cold water when we got back to the site as we were so hot and sore. At last we had found somewhere away from the roads where we could walk although it was still all fenced either side of the paths so you couldn't go to hill summits wherever you wanted to.
We'd intended to maybe go and enjoy some Irish music in a bar in the evening but were pretty shattered. We could hear some from the site though later and weren't particularly impressed - sounded more like folk kareoke with backing tracks rather than live music. We enjoyed the buskers more in the cities
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A new Reuters poll released Friday proved what many Americans know to be true: our country is headed in the wrong direction.
Sixty-two percent of those polled believe the United States is on the "wrong track," while only 23 percent believe the opposite. And no wonder--the national debt is spiraling out of control, our elected leaders ignore the will of their constituents, the Supreme Court engages in unprecedented overreach, and federal bureaucracies regulate every area of our lives.
It's time for a change, but not the one we've experienced the last eight years. This change takes us back to the principles on which our country was founded: strength, freedom, and a limited national government.
An Article V Convention of States can propose constitutional amendments that address each of the problems listed above. These amendments can force Congress to balance the budget, impose term limits on federal officials, and, most importantly, shrink the power and jurisdiction of the federal government. The movement is growing all across the country. Hundreds of thousands of Americans have already signed the Convention of States petition.


text:
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This ebony Bombard is 12.25 inches long, the bell is 3 inches in diameter. Comes with a cane reed. The bombard is a small, double-reed instrument, similar to a soprano shawm in range but shorter in length. A bombard in the key of D is slightly shorter than a soprano recorder in the key of C. These play in D with all the holes closed. Bombards are still used in some Celtic music. They are quite loud, despite their small size. Their tone is high and penetrating.
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Israeli officials squirmed in embarrassment on Friday over Foreign Minister Avigdor Lieberman's ringing endorsement of Russia's contested parliamentary elections as "free and democratic."
Lieberman's comments, which were reported by Russian news agency Itar-Tass, come as Moscow struggles with a wave of protests over allegations of vote rigging in last Sunday's elections.
Top world diplomats have also expressed grave concerns over the outcome of the vote, which observers say was marred by widespread irregularities.
"Such praise is appalling and deeply embarrassing. These remarks in no way reflect our official position," a senior government official told AFP, speaking on condition of anonymity.
Such comments give "an extremely bad impression" he said, adding that the Moldovan-born former bouncer had made his remarks "without consulting" with other Israeli officials.
Senior foreign ministry officials quoted by Haaretz newspaper also described Lieberman's remarks as "disgraceful."
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In a televised meeting with Russian Prime Minister Vladimir Putin in Moscow earlier this week, Lieberman said he had been briefed by a small delegation of Israeli observers, including an MP from his ultranationalist Israel Beitenu party.
"Their answer was quite clear: The elections were absolutely fair, free and democratic. This is my opinion because I rely on our observers," he was quoted as saying.
The elections, which saw Putin's ruling party return to power with a sharply reduced majority, were marred by "frequent procedural violations and instances of apparent manipulation," the Organisation of Security and Cooperation in Europe said.
Earlier this week, both US Secretary of State Hillary Clinton and EU foreign policy chief Catherine Ashton said they had "serious concerns" about the conduct of the elections, with similar concerns raised by Paris and Berlin.
United Russia party won 20 percent points less than the officially announced figure of just under 50 percent, a Russian election monitoring group said Thursday.
The Internet group Citizen Observer (nabludatel.org) said United Russia had received only 29.8 percent nationwide, and 25.8 percent in the Russian capital.
Their figures also gave the liberal Yabloko party enough votes to have won seats in parliament, which was denied them under the official results.


text: Norsk Hydro has exercised one of four seven-day options for the use of the MSV Regalia on the Fram field in the North Sea. The extension runs for 7 days after the fixed contract period which ends 30th July 2003. The value of the option is ca NOK 7,1 million. Prosafe also wants to confirm that the Safe Caledonia is now gangway connected at the Bayu-Undan field offshore Australia, ready to commence its 10-month contract for ConocoPhillips as from 1st July 2003 through to the end of April 2004. ConocoPhillips retain two one-month options that may be exercised by February 2004. The vessel has been on standby-dayrate since 21st May 2003. With reference to the press release dated 30th April 2003 regarding the five long-term bareboat contracts in Mexico, Prosafe informs that the upgrade of the Safe Regency has been commenced already in early June instead of in the third quarter as initially announced. The planned total offhire remains two to three months before the long-term bareboat contract commences, and thus represents a timing difference between the second and third quarter. The Safe Britannia and Safe Lancia, of which the latter came off contract for upgrade on 27th June, will be upgraded during the third quarter, as previously announced. The Safe Scandinavia, which is currently on a 152-day charter for Norsk Hydro on the Grane Field in the North Sea, commenced eight days late due to weather affecting the mobilisation. The delay is a timing difference and does not affect the duration of the fixed contract period.


text:
Client install issues - Legacy uninstall
I'm currently on Trunk version 7981
I'm trying to install the latest Fog Client on a Windows 10 computer.
The computer had a much older version of Fog version 0.1
I uninstalled the Fog version using the Legacy installer then rebooted the system. I then started the updated Smart Installer but It stops and I get an error to uninstall the legacy client. Somehow the uninstall through the legacy client installer must not have uninstalled everything. Can anyone help?
For anyone still having this issue, you can run this tool as Administrator and it will clean up leftovers from the legacy client (only run after you have uninstalled the legacy client): https://build.jbob.io/Tools/CleanLegacyClient.exe.
@jbrabhamMSD I'd need to remote into a problematic machine to identify why the new client still thinks the legacy is present. Send me a PM and we can work out some time that works for both of us sometime next week if it's alright with you.
@Joe-Schmitt Well I feel silly. I'd forgotten that I had posted this and had moved on to new things. And I came back around, looking for the solution again and lo and behold, I see that I had posted the question and there was a reply to it.
Anyways, yes, we upgraded from 1.2.0 to 1.3.4. We have the legacy client (from 1.2.0) on most of our systems and if I uninstall and try to install the smartinstaller.exe or the new msi, I get the message saying that I need to uninstall the old version.
@jbrabhamMSD to be clear here, you just upgraded from 1.2.0 to 1.3.4? And it was the legacy client installed on the problematic computer and not an old version of the new client?
I'm having the same issue. I just updated the server 10 1.3.4 last night. I tried to update the client and it said that I need to uninstall the old version. I uninstalled from add/remove programs. Now it continues to say that I need to uninstall the old version. It is a 64 bit machine that I am working on, so I looked under HKLM\Software\Wow6432Node\Microsoft\Windows\CurrentVersion\Uninstall and HKLM\Software\Microsoft\Windows\CurrentVersion\Uninstall but didn't find {91C5D423-B6AB-4EAB-8F17-2BB3AE162CA1}. I also did a search from the root of the registry for that key.
Tim M
@Joe-Schmitt That worked. Thank you so much. You guys totally rock! When I first introduced the idea of moving to FOG from a paid imaging platform a few years ago, my boss was concerned about support. I have to tell you that the support that all of you and the community provides is far better than anything I have witnessed from companies that we pay.
Joe Schmitt Senior Developer
@Tim-M youll need to look under the
Wow6432Nodefor the key mentioned before, assuming your machine is 64 bit.
If you can wait a day or so, I'm finishing up a snapin that you can deploy to legacy clients, and it'll auto upgrade them to the new one (assuming everything works properly), or it can be deployed via GPO.
Tim M
@Wayne-Workman I am having the same issue. I modified and used your script from the other thread to uninstall the old client and install the new client. It worked fine in most cases. However, when it doesn't work, it doesn't install the new client, and I can't install it manually because the installer keeps detecting the old client even though I can't find any sign of it anywhere. I looked for the registry key that Tom mentioned, but it isn't there. Any insight would be great. I am in the process of migrating about 1,000 machines from a server running 0.32 to one running the latest trunk.
Added to the wiki here:
Wayne Workman Moderator
@Tom-Elliott said in Client install issues - Legacy uninstall:
Before redoing everything, per @joe-schmitt, the registry is scanned for the presence of a particular GUID for the FOG Legacy Installer.
Please Open
regeditand look in:
HKLM\SOFTWARE\Microsoft\Windows\CurrentVersion\UninstallRemove the key with:
{91C5D423-B6AB-4EAB-8F17-2BB3AE162CA1}and try reinstalling, this should work (hopefully).
wiki worthy
@Tom-Elliott That worked!!! Awesome!! You saved me a lot of time. Thanks
Tom Elliott Senior Developer
Before redoing everything, per @joe-schmitt, the registry is scanned for the presence of a particular GUID for the FOG Legacy Installer.
Please Open
regeditand look in:
HKLM\SOFTWARE\Microsoft\Windows\CurrentVersion\UninstallRemove the key with:
{91C5D423-B6AB-4EAB-8F17-2BB3AE162CA1}and try reinstalling, this should work (hopefully).
@Wayne-Workman I am building a clean image as well. This image has a lot of individually installed software applications that I'd like not to have to re-install but if it's the only option then it must be done. Everything else was working perfectly fine on the upgrade, except uninstalling the old Fog and installing the new version.
@kman1232 wow that's a lot to do… why not build Win10 from scratch?
@kman1232 I should mention this image was upgraded to Windows 10 from a Windows 7 install. Now on the Windows 7 install and image the uninstall of the old client and install of the new client when perfect. I think I'm going to just re-install the Windows 7 image and uninstall the old client and install the new client and then upgrade to Windows 10.
@Tom-Elliott Unfortunately same result. I even tried running CCleaner.
@Tom-Elliott said in Client install issues - Legacy uninstall:
@kman1232 what if you reinstall the old and then uninstall from programs?
This is how I do it.
Tom Elliott Senior Developer
@kman1232 what if you reinstall the old and then uninstall from programs?
@Tom-Elliott Yes I have done restarts after each step. It would be interesting to know what the installer checks at the step "Checking for Legacy Client" As whatever that step in the installer is failing on my computer. There must be specific locations on the computer it is checking.


text:
It's commonly understood that an extreme situation can call forth either cowardice or heroism from the very people you would least expect it. There's nothing like a good crisis to reveal the character of the soul or an organization. When one is leading because one's life, and the lives of others, depends on it, then perhaps the best qualities of leadership shine through. This is particularly true when it comes to the issue of leadership and leadership development—strategic areas of focus for the missional church.
I find more often than not when someone asks me, "How are you?", I respond with something to the tune of, "I am good, just really, really busy. We're just in a really busy season right now." I name it as a "season", bringing with that statement the idea that it will pass, that it will somehow transition into something else. But it never does. In fact, I can't think of any time in the past several years that I wouldn't label as "busy". As I look around and see the growing noise and speed of our modern lives, this thought hits me: Time is beginning to be one of the most valuable commodities we have. To invest your time in someone or something is a very precious thing.
An unlikely town. A passionate group of people. One heart to make a lasting difference in a dying community.
All this talk about adventure, risk, and in extremis leadership sounds pretty exhausting. But these are the necessary elements of liminality—that neither-here-nor-there place to which the church is called.


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Reviewed By Dave P (Farley, IA) Reviewed for a 2004 Dodge Ram —7/12/2017 5:59 AM
I shopped around a lot for the perfect camo seat cover's for my 2004 Dodge Ram 1500 Quad Cab and I settled on these. I didn't realize however, that to install them I had to take out the back seat in order to get the straps to go around the back of them and to attach the velcro to the back of the seat. Also, they don't have holes in them for the seat belts to come through so I had to make a few modifications. Overall good appearance and I hope they hold up with all the work they took to put in.


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Kutai National Park
Kutai National Park, Indonesia
Kutai National Park Reviews
378 reviews
Kutai National Park Jul 05, 2011
Up in the northern part of Eastern Kalimantan you'll find the national park of Kutai. The main reason people go there is to see orangutans. Unlike other national parks where you can see orangutans you won't be guaranteed sightings at Kutai - but most people do see them and I certainly did.
The park is a bit away from the other attractions in Kalimantan hence it does get many visitors. With a bit of luck you will be the only one visiting the park when you go there - considering even in the busiest of months they only receive 75 guests during the month. And you should be sure not to have more than a few guests except your own group considering there are only two rooms available to stay overnight. Hence part of the going here is to enjoy the isolation in the jungle.
The park is one of the few remaining jungle area which is still left in East Kalimantan - in the rest of the province the jungle has given way to commercial farming and cities. Even here in the national park the jungle is under threat from illegal logging - and the authorities doesn't seem to do very much in the way of protecting the area from the surrounding world.
The main thing to do in the park is to go trekking a bit in the jungle mainly searching for orangutans. The cute orangutans are certainly the main attractions of the park but there are other animals as well which is also nice to see. I got to see a few birds, and a giant lizard in addition to the orangutans.
Part of the Visit to the first of the Indies travel blog
Part of the list 1234 places to go before I die
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Chamomile has long been used in traditional medicine for the treatment of inflammation-related disorders. In this study we aimed to investigate the inhibitory effects of chamomile on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression, and to explore its potential anti-inflammatory mechanisms using RAW 264.7 macrophages. Chamomile treatment inhibited LPS-induced NO production and significantly blocked IL-1β , IL-6 and TNFα-induced NO levels in RAW 264.7 macrophages. Chamomile caused reduction in LPS-induced iNOS mRNA and protein expression. In RAW 264.7 macrophages, LPS-induced DNA binding activity of RelA/p65 was significantly inhibited by chamomile, an effect that was mediated through the inhibition of IKKβ , the upstream kinase regulating NF-κ B/Rel activity, and degradation of inhibitory factor-κ B. These results demonstrate that chamomile inhibits NO production and iNOS gene expression by inhibiting RelA/p65 activation and supports the utilization of chamomile as an effective anti-inflammatory agent.
Chronic inflammation of longstanding duration plays a critical role in the initiation and development of various human diseases including cancer [1]. Macrophages play a central role in the inflammatory response and produce excess amounts of pro-inflammatory cytokines, pro-inflammatory enzymes and inflammatory mediators, the accumulation of which leads to disease development [2, 3]. Activated macrophages transcriptionally express inducible nitric oxide synthase (iNOS), which catalyzes the oxidative deamination of L-arginine to produce nitric oxide (NO), and is responsible for prolonged and profound production of NO [4]. High output of NO by iNOS induces deleterious effects such as inflammation and cancer [5, 6].
Molecular cloning and sequencing analysis studies have demonstrated the existence of at least 3 main types of NOS isoforms, endothelial NOS (eNOS), neuronal NOS (nNOS) and inducible NOS (iNOS) [7]. Expression of the iNOS gene is regulated at the transcriptional level by the NF-κ B/Rel family of transcription factors, which are involved in regulation of immune and inflammatory responses. The murine iNOS promoter contains two NF-κ B/Rel binding sites located at 55 and 971 base pairs upstream of the TATA box. Moreover, it has been reported that the protein binding to both of these–κ B sites is necessary for the full induction of the iNOS gene by pro-inflammatory mediators such as lipopolysaccharide [8, 9]. In un-stimulated cells, NF-κ B/Rel exists in an inactive state in the cytoplasm, complexed with an inhibitory protein called Iκ B. Upon activation, Iκ B undergoes phosphorylation and degradation and the NF-κ B/Rel heterodimer is translocated into the nucleus where it binds to DNA and activates transcription [10]. A number of inflammatory stimuli and pro-inflammatory cytokines activate immune cells to upregulate inflammation, and consequently are potential targets for exploration of the molecular mechanisms underlying the activation processes, with the aim of developing effective anti-inflammatory drugs to ameliorate their untoward effects.
Chamomile is an herbal plant that has been used for centuries in many human cultures to treat various inflammatory conditions such as eczema, ulcers, gout, neuralgia and rheumatic pains [11, 12]. Dried flowers of Matricaria chamomilla L. are used in the preparation of tea, which is consumed at a rate of more than a million cups per day [13]. The beneficial effects of chamomile are related to the presence of several flavonoid constituents and the core structure consists of either flavone (apigenin, luteolin) or flavonol-derivatives (quercetin, patuletin). These occur in various forms such as aglyco- mono- and di-glycosides and/or acyl-derivatives. Other principal components are essential oils such as terpenoids, α-bisabolol and its oxides, azulenes including chalmuzene and acetylene derivatives [14].
Chamomile has been approved by the German Commission E for oral consumption in the management of various inflammatory diseases of the gastrointestinal tract, and for topical application in the treatment of various skin disorders and inflammatory disorders of certain mucosal surfaces, such as the oral cavity and ano-genital areas [15]. Recent studies have demonstrated its antioxidant, hypocholesterolemic, anti-parasitic, anti-aging, and anticancer properties, supporting its longstanding traditional use for treating various human ailments [16–18]. In previous investigations, we have demonstrated that chamomile is a selective COX-2 inhibitor with anti-inflammatory activities [19]. In the current study, we investigated the effects of chamomile on NO synthesis in LPS activated macrophages and analyzed the underlying mechanisms of action using RAW 264.7 murine macrophages.
Dry chamomile flower of Egyptian origin was purchased from Bec's Tea Nirvana, Cleveland, Ohio. Cell culture medium, DMEM, fetal bovine serum, penicillin–streptomycin cocktail and phosphate buffered saline were purchased from Cellgro Mediatech, Inc. (Herndon, VA). Lipopolysaccharide (LPS, E coli), and apigenin 7-O-glucoside (>95% pure) were purchased from Sigma (St. Louis, MO). Mouse rTNF- α , mouse rIL-6, and mouse rIL-1β were purchased from R&D Systems (Minneapolis, MN). L-NMMA NG-monomethyl-L-arginine, monoacetate salt was purchased from Calbiochem (Brookfield, WI). All reagents used in the experiments were of analytical reagent grade or HPLC grade where applicable.
Dry chamomile flowers were weighed and crushed to powder with a marble pestle and mortar and a 5% w/v suspension was prepared in a flask by adding hot boiled water. The flask was then placed on a shaker (200 rpm) for 4 h and the temperature was maintained at 37°C. After shaking, the flask was brought to room temperature and the suspension was filtered through a series of Whatman filters and finally passed through 0.22 micron filter (Millipore, Billerica, MA). The filtered aqueous extract was freeze-dried and stored at −20°C until use. For cell culture studies, the dried material from aqueous extract was weighed and dissolved in culture medium to achieve desired concentration.
Murine RAW 264.7 macrophages were obtained from the American Type Culture Collection (ATCC) and cultured in Dulbecco's modified essential medium in appropriate culture conditions. Cell stimulation was performed with 1 μg/mL of LPS, mouse rTNF-α , mouse rIL-6, and mouse rIL-1β .
Cell respiration, an indicator of cell viability, was determined by the mitochondrial-dependent reduction of 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) to formazan. After the supernatants were removed for nitrite assay, cells were incubated at 37° with MTT (0.5 mg/mL) for 45 min. The medium was aspirated and cells were solubilized in dimethyl sulfoxide (250 μL) for at least 2 h in the dark. The extent of reduction of MTT was quantified by optical density measurement at 550 nm.
RAW 264.7 macrophages were cultured in 6 well plates. After incubation with LPS and other cytokines and various doses of chamomile for 12–24 h, nitric oxide synthesis was determined by assaying the culture medium for nitrite, which is the stable reaction product of nitric oxide with molecular oxygen, using Griess reagent kit obtained from Biotium (Hayward, CA).
Macrophages, grown in 6-well plates to confluence, were incubated with or without LPS in the absence or presence of the test agents for 16 h. Cells were washed with ice-cold PBS and stored at 70° until further analysis. Frozen plates were put on ice and cells were lysed in 1% Triton X-100, 0.15 M NaCl, and 10 mM Tris-HCl pH 7.4 for 30 min. Lysates were homogenized through a 22 G needle and centrifuged at 10,000 g for 10 min at 4°. The supernatants were collected and protein was measured by the method according to Bradford, 1976 [20]. Cell lysates, containing equal amounts of protein, were boiled in SDS sample buffer for 5 min before running on a 10% SDS–polyacrylamide gel. Proteins were transferred to polyvinylidene fluoride membranes (Invitrogen, Carlsbad, CA). Membranes were blocked with 5% fat-free dry milk in TBS-T pH 8.0 (Tris-buffered saline [50 mM Tris, pH 8.0, 150 mM NaCl] with 0.1% Tween 20) and then incubated with antibodies viz. anti-iNOS (SC-7271), anti-Iκ Bα (SC- 1643), anti-NF-κ B/RelA (SC-8008) anti-β-actin (SC-47778) obtained from SantaCruz (SantaCruz, CA), anti-p-IKKα /IKKβ (Ser180/181; Cat#2681), anti-p-Iκ Bα (Ser32/36; Cat#9246) obtained from Cell Signaling Technology (Beverly, MA) with appropriate dilutions and incubated overnight at 4°C. After washing 3 times with TBS-T, and the bands were visualized by using appropriate IgG:horseradish peroxidase conjugate and the enhanced chemiluminescence system (ECL , Amersham Pharmacia Biotech). Signal intensities were evaluated by densitometric analysis (Kodak Digital Science Image Station 2000R Life Science Products).
RAW 264.7 cells (5 × 106 cells-100 mm dish) were incubated for 8 h with or without various concentrations of chamomile and LPS (1 μg/ml). After washing with PBS twice, total RNA was isolated from the cell pellet using RNA isolation kit (Invitrogen, CA). The total amount of RNA was determined by absorbance at 260 nm. One microgram (μg) of RNA was reverse transcribed into cDNA using avian myeloblastosis virus (AMV) reverse transcriptase and oligo(dT)15 primer (Promega Co., Madison, WI, USA). The PCR samples contained 50 μl of the reaction mixture, comprised of 50 mM KCl, 5 mM MgCl2, 0.16 mM dNTP, 5.0 units of Taq DNA polymerase (Qiagen, Valencia, CA, USA), and 20 pmol of sense and antisense primers in 10 mM Tris-HCl (pH 8.3). The primer for iNOS were 5'-CAGTTCTGCGCCTTTGCTCAT-3' (sense) and 5'-GGTGGTGCGGCTGGACTTT-3' (antisense), and those for GAPDH 5'-AGGCCGGTGCTGAGTATGTC-3' (sense) and 5'-TGCCTGCTTCACCACCTTCT-3' (antisense). The PCR amplification was performed under the following conditions: 30 cycles of denaturation at 98°C for 30 sec, annealing at 60°C for 30 sec and extension at 74 °C for 1 min, using a thermal cycler (Px2, Thermo Electron Corporation). The amplified PCR products were run on a 2% agarose gel and visualized by SYBR Gold staining.
EMSA for NF-κ B was performed in the nuclear fraction of RAW 264.7 macrophages incubated for 16 h with or without various concentrations of chamomile and LPS (1 μg/ml) using LightshiftTM Chemiluminiscent EMSA kit (Pierce Biotechnology, Rockford, IL) following manufacturer's protocol as previously described [21].
Nitrite estimation and cell viability were performed in triplicate. All experiments were repeated at least twice. Results are expressed as mean values ± SEM. Statistical comparisons were made by ANOVA followed by a Dunnett's multiple comparison test. P values < 0.05 were considered significant.
First, we performed HPLC analysis on aqueous chamomile extract with reference to apigenin 7-O-glucoside, the major constituent of chamomile. As shown in figure 1A, HPLC analysis demonstrated two major peaks with retention times of 1.179 min (27.7%) and 1.520 min (63.3%) and 5 other minor peaks which together constitute 90% of the total flavonoids. The two major peaks in the aqueous chamomile extract correspond to apigenin 7-O-glucoside (63.3%) and apigenin 7-O-neohesperidoside (27.7%), which was further confirmed by LC-MS analysis as previously demonstrated [12].
Next we standardized aqueous chamomile extract with doses equivalent to molar concentration of apigenin 7-O-glucoside. For this study, different concentration of apigenin 7-O-glucoside were prepared in methanol and subjected to HPLC (Figure 1A). The peak area (retention time 1.5 to 1.7 min) were calculated and plotted to obtain a standard curve, which corresponded to the concentration of apigenin 7-O-glucoside in the aqueous extract on the basis of peak area (Figure 1B).
Following this, we determined the effect of aqueous chamomile extract on inhibition of constitutive NOS expression in RAW 264.7 cells by measuring the levels of total nitrite. The amount of nitrite, a stable metabolite of NO in the cell culture medium was estimated using Griess reagent as an index for nitric oxide. RAW 264.7 macrophages in the un-stimulated state produced 0.98 + 0.01 μM nitrite in the medium. Treatment of macrophages with chamomile cause a modest decrease in the endogenous NO levels in RAW 264.7 cells which was more pronounced at 20- and 40-μg/mL doses of chamomile (Figure 1C). Chamomile exposure did not affect cell viability at the test concentration up to 40-μg/mL. At 80-μg/mL chamomile, a modest decrease in cell viability was observed.
Since IL-1β , IL-6 and TNFα are known pro-inflammatory cytokines and LPS causes NO production, we examined whether chamomile is capable of inhibiting NO levels after challenge with these pro-inflammatory mediators. As shown in figure 2A-D, chamomile at 10- and 20-μg/mL doses significantly blocked NO production after challenge of RAW 264.7 cells with these molecules up to 40–60%. Since the NO production was highest with LPS challenge, therefore for further experiments we used LPS (1μg/mL).
Next we performed time course experiments to determine the decrease in levels of NO by chamomile. As shown in figure 3A, treatment of RAW 264.7 cells with 10-μg/mL for 3 h to 48 h caused a significant decrease in NO production in the culture medium by 16.6% starting as early as 3 h and 79.8% at 48 h, respectively. In dose-dependent assay, treatment of RAW 264.7 macrophages with LPS for 24 h, the nitrite concentration in the culture medium increased to about 30-fold. Treatment with chamomile caused a significant decrease in NO production with 53.3% at 5-μg/mL to 83.3% at the highest dose of 40-μg/mL, respectively. However, a decrease of 23.3% in NO production was achieved after treatment of RAW 264.7 macrophages with L-NMMA, a non-selective inhibitor of all NOS isoforms (Figure 4B).
The marked reduction in nitrite production with chamomile suggests that it might also affect the iNOS protein expression. Therefore, we examined iNOS protein expression by Western Blot analysis. As shown in Figure 4A, RAW 264.7 macrophages incubated with LPS (1μg/mL) in the absence and presence of chamomile at 10–40 μg/mL concentration for 16 h and the cell extract were examined for 133 KDa iNOS protein. As shown in figure 4A, reduced iNOS protein expression were observed after chamomile treatment compared to LPS alone challenge, which was dose-dependent. At the message level, chamomile treatment to LPS challenged RAW 264.7 macrophages resulted in a modest decrease in mRNA expression (Figure 4B).
Since LPS-mediated activation of NF-κ B is associated with prolonged activation of IKK, the upstream kinase, we first sought to determine whether chamomile can alter the level of this kinase. As shown in figure 5A, LPS challenge to RAW 264.7 macrophages resulted in a significant increase in phosphorylation of IKKα /β which was markedly reduced with chamomile treatment in dose-dependent manner. Activation of IKK leads to the hyper-phosphorylation of Iκ Bα as well as its subsequent degradation therefore next we measured the cytosolic levels of Iκ Bα and its phosphorylated forms. Treatment with chamomile resulted in an increase in the total levels of Iκ Bα in the cytosol whereas a significant decrease in the p-Iκ Bα at Serine 32/36 was observed after chamomile treatment which was dose-dependent. Furthermore, treatment of RAW 264.7 cells with chamomile caused a decrease in the nuclear levels of NF-κ B/p65 which correlated with a simultaneous increase in the cytosol in dose-dependent manner (Figure 5B).
To further confirm NF-κ B-mediated iNOS gene regulation, an EMSA was performed using an oligonucleotide containing a consensus RelA/p65 binding sequence in the nuclear fractions prepared after LPS challenge and chamomile treatment. A strong NF-κ B band was observed in response to LPS- induced activation which was reduced with chamomile treatment (Figure 5C). These results demonstrate that chamomile blocked NF-κ B activation, which might account for the inhibition of iNOS induction in RAW 264.7 macrophages.
Chamomile is known to possess anti-inflammatory and antioxidant effects. In the present study, we demonstrated that chamomile inhibits NO production and iNOS expression in macrophages, and showed that these effects are mediated through the inhibition of NF-κ B/Rel transcription factor. As stated earlier NO plays an important role in the pathogenesis of various inflammatory diseases, including cancer. Therefore, the inhibitory effect of chamomile on iNOS gene expression suggests that this is one of the mechanisms responsible for its anti-inflammatory properties.
Macrophages play a central role in a host's defense against various infections by nature of their phagocytic, cytotoxic, and intracellular killing capacities [22]. Stimulation of murine macrophages by LPS, the major component of Gram-negative bacterial cell walls, results in expression of iNOS [23]. Increased production of NO plays a critical role in the process of macrophage activation and is associated with acute and chronic inflammations [24]. Therefore, the suppression of NO production by inhibition of iNOS expression and/or enzyme activity is potentially a very important therapeutic strategy in the development of therapeutic anti-inflammatory agents. In the current study, we have demonstrated that chamomile inhibits LPS-induced NO production in RAW 264.7 macrophages. The inhibitory effect of chamomile was mediated via a reduction in iNOS both at the protein and message levels.
Macrophages are capable of secreting various mediators such as IL-1, IL-6, granulocyte- macrophage colony-stimulating factor (GM-CSF) and TNFα , which lead to secondary immune responses such as proliferation of T and B cells, activation of macrophages for phagocytosis, and killing of microorganisms. Among these mediators, pro-inflammatory cytokines such as IL-1β , IL-6 and TNFα can be generated in response to immunological reaction, inflammation and microbial invasion [25]. Therefore, we sought to examine whether chamomile could alter NO production after incubation of RAW 264.7 macrophages with these cytokines along with chamomile. Our results demonstrate that chamomile may, in part, exert inhibitory effects on pro-inflammatory cytokines through inhibition of NO production in RAW 264.7 macrophages.
NO production by iNOS is regulated mainly at the transcriptional level, and the expression of the iNOS gene in macrophages is under the control of several transcription factors, which include NF- κ B/RelA [26]. The cis-acting NF-κ B element's presence has been demonstrated in the 5′ flanking regions of both the COX-2 and iNOS genes [27, 28]. Recently we have demonstrated that chamomile differentially inhibits LPS-induced COX-2 activity and expression in RAW 264.7 macrophages [19]. NF-κ B is functional as a hetero- or homo-dimeric form of the Rel family proteins, including RelA (p65), RelB, cRel, p50 and p52 [29. In resting cells, cytoplasmic Iκ B proteins (Iκ Bα , Iκ Bβ , and Iκ Bε) are associated with NF-κ B dimmers, and some stimuli, such as IL-1β and LPS, lead to prolonged activation of IKK, the upstream kinase regulating NF-κ B [30]. Our studies demonstrate that chamomile in a dose-dependent manner suppresses LPS-mediated IKK expression, NF-κ B activation and its translocation to the nucleus. These results suggest that chamomile inhibits the expression of iNOS and thus NO production, a process that is mediated through inactivation of NF-κ B by reducing Iκ Bα degradation and phosphorylation.
It is well known that RelA/p65 is a critical transactivation subunit for NF-κ B [31, 32]. Our studies performed through EMSA demonstrate that chamomile inhibits RelA/p65 activation. Moreover, recent studies have demonstrated that the transcriptional activity of RelA/p65 subunit is regulated by posttranslational modifications such as phosphorylation and acetylation [33]. It has been shown that the phosphorylation status of RelA determines whether it associates with CREB-binding protein/p300, which is a critical regulator of NF-κ B [34]. In this regard, it is possible that chamomile suppresses transcriptional activity of RelA/p65 by modifying the phosphorylation or acetylation status of the RelA/p65 subunit. Further studies are required to understand as how chamomile regulates the transcriptional activity of the RelA/p65 subunit.
In summary, this study demonstrates that chamomile inhibits LPS-induced NO production and iNOS gene expression in macrophages and that these effects are mediated, at least in part, through blockage of NF-κ B/Rel transcriptional activation. The fact that NF-κ B/Rel is negatively regulated by chamomile is important, because this transcription factor plays a critical role in the regulation of a variety of genes that are involved in inflammatory responses. Since chamomile is a nontoxic and pharmacologically active compound that has demonstrable inhibitory effects on iNOS gene expression, and since NO plays an important role in mediating inflammatory responses, our study supports the utilization of chamomile as a potentially effective therapeutic anti-inflammatory agent.
Financial Support: This work was supported by grants from United States Public Health Services RO1 AT002709 and RO1 CA108512
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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The Infinix Zero 2 is one of the latest and the hottest Android device in town now, stylish designed, slimmer, lighter and tougher. The Infinix Zero 2 is available and still selling fast at Konga – Buy Now
The below tutorial will help the Infinix Zero 2 users to Root and
change the Imei of their Smartphone easily in other to flex with Glo Bis on
it and the rooting will make you enjoy your phone to the fullest.
Materials Needed
KingRoot 126.96.36.199.apk [Download it here]
Strong Internet connection [Town ON your Data Connection is highly recommended]
To Root Your Infinix Zero 2
1. Install and run Kingroot. Wait till it detect the phone
1. First of all, you need 15 Digits Blackberry Generated IMEI. Simply download BBGEN.apk version here, to generate BB IMEI on your Android Device or Download GIPv4.1 Software to your PC here
2. Also download and install MTK Engineering Mode from play store.
3. Open it and click on MTK Settings
4.Then wipe your screen to left site to see Connectivity options.
5.Scroll down to CDS Information and tap on it.
For Phone 1:
"AT+EGMR=1,7,"YOUR NEW IMEI NO" (make sure you put a space between AT +EGMR)
For Phone 2:
"AT+EGMR=1,10,"YOUR NEW IMEI NO" (make sure you put a between space AT +EGMR)
10. After that, select SEND AT COMMAND. You will see a message "AT Command Msent"
11. Close everything and restart your phone, then dial *#06# to view your new
12. Now, configure the APN of your Smartphone with blackberry.net and activate it as your default setting. You can then subscribe to Glo Bis by
dialing *777*21# or text COMONTH to 777 for just N1,000 and you are good to enjoy Glo Bis on your Innjoo Fire!
Note that
Changing of IMEI is illegal in some countries, and 360baze will not be
held responsible for any consequences that befall the changer.
Also, backup your original imei incase anything goes wrong then revert using
the above procedures for changing.
Good Luck and don't forget to drop your comment, if the method work for your phone.
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Would You Advertise on Your Car For Money and Free Gas?
Employees at Jobing.com have the option of getting their cars wrapped in the company's advertisement in exchange for $500 a month in free gas.
Workers are reimbursed for any gas they use, not just the mileage it takes to get to and from the office. The company's marketing director said that this year there's a waiting list for cars awaiting a Jobing makeover.
Would you take advantage of this type of incentive if your company offered it?


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CONNIE WILLIS (Signed) WINDS OF THE MARBLE ARCH Sub Press 1st Edition Hardcover
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CONNIE WILLISTHE WINDS OF THE MARBLE ARCH 1st Edition Hardcover, Signed by 2 CONNIE WILLIS is an American writer famous for her award-winning science fiction. Here is a signed copy of one of her books. THE WINDS OF THE MARBLE ARCH AND OTHER STORIES , Subterranean Press, 2007, stated first edition on the copyright page , $40.00 jacket price. The hardcover book is in VG+/NF- condition with slight wear. The dust jacket is in similar condition and is now in a removable mylar jacket protector. No remainder marks. This is not a book-club edition or an ex-library copy. SIGNED on the title page by CONNIE WILLIS and by jacket artist JOHN JUDE PALENCAR . I combine shipping on multiple items. I normally ship the day after I receive payment. To keep postage costs down for buyers, I prefer to use USPS media mail for US buyers ( USPS First Class International for out-of-country buyers ), but I can ship Priority mail (at a higher cost), if you need it more quickly. I charge a $.75 handling fee (included in the quoted shipping price) for each package sent, regardless of the number of items in that package. Buy one book, $.75 handling fee. Buy 20 books, $.75 handling fee. That partially offsets the cost of the box, the bubble wrap or other packaging materials, tape, labels, and the ever-increasing ... read more


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Dark theme to make
bandnan replied to bandnan's topic in Off-topic LoungeNo idea, i haven't worked on it for awhile.
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After domain change - icons/images error
bandnan replied to mojo187's question in IPS 4.1 SupportI had this problem as well recently. Try removing the contents of datastore and or turn on Design mode for your current theme then turn back off. Make sure to synchronize the changes when turning off.
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Dark theme to make
bandnan posted a topic in Off-topic LoungeOk so im back again from a another long break and im ready to do some more work. For anyone who knows i made a dark theme of Nerva found here: I'm looking to make another dark theme for IPB using the latest version. I plan to keep it up to date with all the changes. So im taking suggestions on a theme to convert to a Dark gaming skin. i might even create a theme from scratch one day, but thats in the future. so let me know what you think and like. I'm ready to start.
ah yes the key is 123-12-1234 i forgot to mention it is indeed nulled tho. Edit* and i would like to see the community.
I havent been able to get my dev server up yet, but the file is approved so feel free to test it.
i believe so, i am testing it now.
Late finding for me, i have uploaded it, i'l post the link once it is aproved.
Sngine - The Ultimate PHP Social Network Platform
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Version 2.3
107 downloadsSngine is a Social Network Platform is the best way to create your own social website or online community. Launch it in just 1 minute with ultimate features. It's fast, secured, and it will be regularly updated. Sngine is very easy to install, Watch how to install in less than 1 minute Sngine is the Fastest Social Network Script on Codecanyon Google PageSpeed 97/100 Demo User Demo:: Demo Link (You can register and test it yourself) Admin Demo:: Demo Link (Login using this username/password) Username: demo.admin Password: 123456 (This account can't do any action on the demo version)
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Nerva & IPSMake
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Version 1.1.0
547 downloadsVery clean a skin with advanced features designed for the IPS 4.1.x Fully customizable with features you can create a website that you want. NERVA WITH RENEWED INTERFACE All frames were rebuilt. WARNING: All customers who have previously purchased the first version Please uninstall the old version before installation, install the new version. Because skin has been completely renovated. Compatibility: IPS Community Suite 22.214.171.124 +
User login and Regitration
bandnan posted a question in IPS 4.1 SupportHello, i am looking to have the user login form and registration form on the same page, is there a way to do this, and also redirect the login popup to the page.
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bandnan replied to NeXus . Test's question in IPS 4.1 Answered Questionsremove the body tag from the ::-webkit-scrollbar-corner{background:transparent} e Webkit scrollbar. example change: body::-webkit-scrollbar{width:0.775em;}body::-webkit-scrollbar-thumb{background-color:crimson;} to ::-webkit-scrollbar{width:0.775em;}::-webkit-scrollbar-thumb{background-color:crimson;} and you can add ::-webkit-scrollbar-corner{background:transparent} to remove the white box
Gaming Community logo
bandnan replied to KleineError's topic in Website and Graphics Designprobably not the best but hey its a try :) or just some ideas, let me know if you would like a different design.
Nerva Dark v1 - Progress Report
bandnan replied to bandnan's topic in Website and Graphics DesignThe first version has been released
Nerva Dark 4.1.x
bandnan posted a file in Themes
Version 0.0.9
540 downloadsAbout This File This skin is a remake of Nerva 4.1.x & IPBForo 1.0.9 in Dark Form. Very clean a skin with advanced features designed for the IPS 4.x. Fully customizable with features you can create a website that you want. Nerva with advanced features designed for the IPS 4.x is a clean skin. Nerva was rebuilt with skin v1.0.1 release. We attach great importance to the fact that we produce the skin at the same time user-friendly. Compatibility: IPS Community Suite 18.104.22.168 IPS Applications: 1) Forums, 2) Calendar, 3) Chat, 4) Downloads, 5) Commerce, 6) Pages, 7) Blog, 8) Gallery.
bandnan started following Nerva Dark 4.1.x
Nerva Dark v1 - Progress Report
bandnan posted a topic in Website and Graphics DesignNerva Dark v1 - Progress Report Some of you may know i have begun work on the Nerva theme, to transform it into a dark theme. i decided to post a update on how things are going and looking form some suggestions to be made Still to do/planned: change up colors, to appall visitors. change the header background. change message block background (suggestions would be nice). rework notification/alerts. add more options in theme config for easy change. rework profile page. more to come. Here is the sticky nav bar.


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Search Planologieblog
- Today's Moment of Idealistic Naivete: Wikileaks: http://wp.me/pCprU-mB 6 years ago
- Ending the War on Drugs: http://wp.me/pCprU-mw 6 years ago
- Twilight Of The Suburbs, Now Home To One-Third Of America's Poor http://huff.to/bGZP7F 7 years ago
- U.S. Subways Harness Kinetic Power To Recycle Train Energy http://huff.to/bVsXvR 7 years ago
- America's Walk Deficit http://yhoo.it/dijIvg 7 years ago
Recent Posts
- Today's Moment of Idealistic Naivete: Wikileaks
- Ending the War on Drugs
- The Most Walkable Cities in the World
- It's Where We Live
- Can Cities Feed Themselves?
- French Street Artist Wins TED Humanitarian Prize
- Dimanche Sans Voiture
- Are Brussels and Los Angeles Sister Cities?
- Masdar begs the question: What exactly is meant by "a sustainable city?"
- Is Generation Y Passing on Cars?
- Can Cities Make Us Crazy?
- Stranger Studies 101: Cities as Interaction Machines
- Does New Orleans Have an Identity Crisis?
- Three Urban Interventions in Two Hours: NYC
- Cargo Bike Spotted…
Category Archives: Shout Outs
Why We Need Innovation, Not Insulation
Conservation and behavior change alone will not get us to the dramatically lower levels of CO2 emissions needed to make a real difference. We also need to focus on developing innovative technologies that produce energy without generating any CO2 emissions at all.
Continue reading
Food for Thought: Muhammad Yunus
source Excerpted from Knowledge@Wharton My greatest challenge has been to change the mindset of people. Mindsets play strange tricks on us. We see things the way our minds have instructed our eyes to see." continue reading at knowledge.wharton.upenn.edu
Creating Car-Reduced and Car-Free Pedestrian Habitats
It will take a long time for the US to embrace pedestrians, bicycling, and electric carts as substitutes for cars in our communities. And yet an inevitable change is coming that will significantly increase environmental quality, and restore real community and economic viability. Changing legislation, master planning, and the development of car-reduced and car-free communities will move us forward, writes Greg Ramsey. Continue reading
Posted in Auto Independence, Culture, human scale, Livability, Placemaking, Shout Outs, Sustainability, transit, Transportation, walkable, What if? Tagged auto-dependence, car-centric planning, car-free, car-reduced, cohousing, community, connectivity, Copenhagen, eco-villages, electric cart, Greg Ramsey, human scale, mixed-use, New Orleans, pedestrian, people-centric, Placemaking, planetizen, sprawl, St. Augustine 4 Comments
Our Back Yard: Open & Playful in a Land of Fences
Unlike many parents these days, I have no desire to invest in expensive play equipment, then have it used only by my children and the kids they invite over for playdates. So, my number one goal for the features I installed in my back yard was enticing neighbor kids to freely go around, over, or through our back fence to use them on a regular basis. That means they have to be very attractive, and also that means that I need to reach out frequently to those neighbors with whom we share fences to establish and maintain good relations. Continue reading
Posted in Culture, Livability, Neighbors, Placemaking, Shout Outs, What if? Tagged community hangout, making private spaces public, Mike Lanza, neighborhoods, playborhood, playhouse, swing set 1 Comment
Enrique Penalosa – City of Equality
During his three-year term as mayor of Bogotá, Colómbia, Peñalosa implemented profound changes which transformed the capital and changed the attitude of its 7 million inhabitants. He massively improved slums, built formidable schools and nurseries, beautiful libraries and hundreds of parks and other pedestrian spaces. He was a leading innovator in America in creating a bicycle path network, restricting car use and radically improving pedestrian facilities, building more than a hundred kilometres of pedestrian streets and greenways. Inspired by the Curitiba model, he created the TransMilenio bus transit system which has been a role model to many cities.
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iPhone X review
PC Upgrades Feature
Tech Advisor January 2018 Digital Edition
Latest issue of Tech Advisor out now. Windows 10S: Microsoft's OS for students
Nvidia GeForce GTX 1080 Ti vs 1080 vs 1070 vs 1060 vs 1050
Here are the key differences between the GeForce 10-series graphics cards
8 tech resolutions for 2017: Best practises for the New Year
Technology New Year's resolutions you can easily keep
Windows 10 tips and tricks | Windows 10 anniversary update new features
From customising the Start Menu to Cortana's latest tricks, here are the best Windows 10 tips
AMD RX 480 vs RX 470 vs RX 460
We look at the AMD Polaris cards and compare their specs. Read on to see which one is the best for you.
What is MU-MIMO?
MU-MIMO technology is growing in popularity. Here's what you need to know about the 802.11ac technology.
How to extend the life of your PC and components
We explain how to get the most out of your PC components
Sony sells Vaio PC business to focus on smartphones and tablets
Sony quits PC market and restructures TV division, will focus on smartphone and tablet
Windows 8.1 Update 1 leaks online
Tweaks to Windows 8.1 will aid PC users without touchscreens
[email protected] IT support launches in London
[email protected] sees IT students provide technical support for Londoners with computer problems
Windows 8.1 release date and new features UK
Everything you need to know about Windows 8.1 release date and new features
Lenovo to reinstate Windows Start menu
Pokki will come pre-installed on Lenovo's Windows 8 PCs and laptops
Should I upgrade my PC
We help you device if it's worth upgrading an old laptop or PC, or best to buy a new one
Windows 8.1 RTM coming in August
Devices running Windows 8.1 to arrive 'just in time for the holidays'
What's so great about Haswell?
Intel's fourth-generation Core processors use less power than ever
Get a PC for just £24
Microsoft backed scheme aims to get more people in Britain online
Best Graphics Card 2013
We announce the winner of our Best Graphics Card award
Three simple ways to get a speedy PC
How anyone can enjoy a faster PC
Windows 8 Pro price drop was an error
Microsoft confirms mistake but will honour cut price purchases
Microsoft Office 2013 and 365 FAQ: What you need to know
Your Office 2013 and Office 365 questions answered


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8 years 28 weeks ago, 8:23 AM
DoubleTap Ammo - Great sight
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Cut and contoured to stay out of your way, Won't sound the horn or try to start the bike while you do a U turn.
What's in the box?
1 x Andy Strapz Tank Bagz
1 x Universal-fit stretch harness
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"If you know you want a tank bag but are a bit bamboozled by all the available options, this one has all their good bits sewn into one." — Andy
Initially designed for bikes with plastic and alloy tanks, it quickly became obvious that we had a pretty good all-round do-it-all tank bag. The bag itself is scalloped to reduce contact with both the horn and the starter button and the lid opens a true 180 degrees for a clear view of all your contents inside. This, combined with the good-sized zippers means I can just pull over, open the bag and take a photo — while still wearing gloves, helmet and all.
My design brief for this bag was fairly detailed; the tank bag must not interfere with the switch gear or my view to the instruments. It needed to use its space wisely without being cumbersome and encroaching on belly space, the zippers needed to be good quality, not rattle and be operable with cold, glove-laden hands, the bag itself needed to sit securely and not bounce around and the lid needed to open fully.
Once developed, my 20,000km shakedown test taught me I needed to add bit of colour to the inside base to ensure that my things don't get lost in the great black tank bag void.
It also taught me refuelling needs to be able to happen really easily or else I'm going to opt for a rear-mounted seat bag instead. We've developed an innovative one-touch system to facilitate this, and one clip at the front has the entire bag rotating onto the rider's seat. It's got padded sides and a padded base to protect both the bag's content and the bike's tank and the whole thing converts to a handy backpack in seconds.
Our unique stretch harness will fit almost any bike — it is truly universal. it comes with four flat stainless steel strips enclosed in webbing to be bent to a shape to best fit your bike as well as two straps with loops at the end to slip over — well, just about anything — to give owners heaps of attachment options.


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Capello clashed with a GT class Porsche 10 minutes into the race, causing bodywork damage and a flat tyre. With the early damage, the Audi completed the race on one rear set of tyres.
Australian David Brabham driving with Jan Magnussen in a Panoz was second, while series points leaders Jorg Muller and JJ Lehto were third in a BMW.
"It would have been nice to go one better, but I really enjoyed the race today," Brabham said. "I had a little bit of damage to the front bodywork with caused a small off-track excursion. That lost us too much time to really have a go at the Audi."
After leading early, the Emanuele Pirro and Frank Biela Audi combination finished fourth.
Former Ferrari Grand Prix driver Stefan Johansson completed the top five in the Reynard he shared with young Briton, Guy Smith.
The Dodge Viper squad was back to its winning ways in the GTS division with Karl Wendlinger and Olivier Beretta taking the win for the ORECA team.
Australian GT team owner Rohan Skea had a bad day when co-driver Doc Bundy crashed their Porsche GT3-R, one hour into the race. Although he climbed out of the crashed car, Bundy was later transferred to hospital for observation.
Results:Prototype division
1. Rinaldo Capello/Alan McNish - Audi - 136 laps
2. David Brabham/Jan Magnussen - Panoz - 136 laps
3. JJ Lehto/Jorg Muller - BMW - 135 laps
4. Frank Biela/Emanuele Pirro - Audi - 135 laps
5. Stefan Johansson/Guy Smith - Reynard - 135 laps
GTS division:
1. Karl Wendlinger/Olivier Beretta - Dodge Viper - 123 laps
GT division:
1. Sascha Maassen/Bob Wollek - Porsche GT3-R - 121 laps


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In Destined for Destiny, "George W. Bush" offers listeners an intimate, plainspoken, and sometimes articulate look at the character-shaping achievements that led to his inevitable rise to the office of President of the United States.
Written from the heart, not from the brain, this definitive autobiography takes listeners on a journey through the 43rd president's life, including his hardscrabble beginnings as the child of West Texas oil millionaires, the remarkable academic performance that earned him entry into the finest East Coast schools, and his proud service to the country as an occasional member of the National Guard, sometime around 1972 or 1973.
To help craft this lasting account of his life and leadership, "George W. Bush" turned to two writers who have earned not only his trust but his deep friendship: Scott Dikkers, editor-in-chief of The Onion and coauthor of the number-one best seller Our Dumb Century, and Peter Hilleren, former producer for public radio and some of the nation's finest public-access cable television stations.
Dikkers and Hilleren called on their finely honed journalism expertise every week to write and record the president's weekly radio address on WeeklyRadioAddress.com. Their work on such stirring addresses as "June Terror Update" and "The Pope Is Dead" made them the ideal choice to meet the challenge of chronicling the visionary mark left on history by its shining light, President George W. Bush.
"Bush detractors will find this book hilarious; his fans will be apoplectic." (Booklist)
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Some dogs prefer a wet diet, others like it mixed with dry food but whatever their favourite, our trays of Chicken with Rice & Vegetables dog food contain everything they need for a healthy, active life. Lovejoys® are proud to make wheat and gluten free dog food that is ready to eat and hypoallergenic. Our meals are made using 60% fresh, farm-reared chicken with a nutritious blend of brown rice and vegetables. We include seaweed oil to support your dog's brain, vision and nervous system, plus glucosamine and chondroitin to aid healthy joints. At Lovejoys® we only use the best ingredients available to make great tasting foods for dogs of all breeds and sizes. We don't use artificial colours, flavours or preservatives in any of our products. Naturally good is the way we make them and we promise that we always will.
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BREED TYPE WEIGHT OF DOG TRAYS PER DAY (395g) Toy 1-5kg ¼-¾ Small 5-12kg ½ – 1 Medium 12-25kg 1 - 2 Large 25-45kg 2 - 3 Extra Large 45-70kg 3 - 4
The amounts given are recommendations only, individual requirements will vary dependent upon breed, age and activity levels. Feed to maintain a lean, active condition. Remember to introduce a new food gradually over four days or so, increasing the proportion of new food daily.
Many owners like to feed a mixed diet, part dry and part wet. For owners who prefer this method we recommend that whatever amount you reduce the dry food by, you replace with double the amount of wet food. For example, if you normally feed your dog 150g of dry food and you reduce the amount to 100g, we would recommend you replace it with 100g of Lovejoys wet food.
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Praise Trailer (1998)
"Sex and drugs in BrisVegas!" 11 September 1998 Drama 98 mins
An unfocused twentysomething (Peter Fenton) moves in with a former co-worker (Sacha Holder), who is suffering from low self-esteem because of her weight, looks, and a case of eczema. Their relationship is based on unending drink, drugs, and sex. Curiously, though the two are presented in a tender and humorous light that lets the viewer get involved in concerned about their direction.
Watch the official Praise 1998 trailer in HD below or find more Praise videos on Vidimovie.


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Evans doubtful for Inter tie
Jonny Evans is doubtful for the club's UEFA Champions League trip to Inter on Tuesday.
By Richard Bailey
Last Updated: 22/02/09 5:48pm
Manchester United defender Jonny Evans is doubtful for the club's UEFA Champions League trip to Inter on Tuesday.
The Northern Ireland international limped out of the 2-1 win against Blackburn on Saturday and must now wait for news on the problem.
The injury is suspected to be a recurrence of the ankle problem that the 21-year-old picked up in the Carling Cup semi-final second leg against Derby.
Evans missed five games with the injury before returning for the 3-0 win over Fulham last Wednesday.
The youngster will be missed by Sir Alex Ferguson's team with fellow defenders Nemanja Vidic suspended for the Inter match and Wes Brown and Gary Neville out through injury while John O'Shea may have to be rushed back from a heel injury.
"It is a recurrence of the ankle injury I had before and is a bit tender," Evans revealed to the Manchester Evening News.
"I caught it when I kicked the ground during the game. At this point, I don't know whether I will be fit for the San Siro.
"The doctor said he will have a look at it, and he will have a better picture then."
Meanwhile Ferguson added: "We are having a nightmare with defenders this season.
"The defenders are being changed all the time. You reach a point when you start to find it hard."


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The SkyCam project is similar to The Night Sky Live which uses CONCAM (CONtinuous CAMera) all sky cameras to take images of the entire sky all night long. The images are then analyzed using this software and the data is made freely available for scientific and educational use. Update: the Night Sky Project is no longer active, see: State of the Night Sky Live Project.
A camera with a wide-angle lens has been installed at Ladd Observatory. This project will document the setup, configuration and operation of the camera. Possible topics include meteorology (cloud cover), detecting meteors and orbiting satellites, and possibly measuring brightness changes of variable stars.
Camera system[edit]
The camera system is a commercial off-the-shelf model manufactured by Santa Barbara Instrument Group. It includes a weatherproof housing with a window that is heated to prevent condensation. The window is an optical filter that transmits light from 630 - 1000 nm (red to near infrared) and is used to block light pollution. Inside is an ST-402ME digital imaging camera which uses a monochrome 16 bit per pixel Kodak KAF-0402ME CCD chip with 9 micron pixel size. The camera body is mated to a Computar fisheye lens with 2.6mm focal length and a 1.6 focal ratio. The field of view is about 140 x 90 degrees.
The Sky Camera was permanently mounted on the roof of the Ladd Observatory on Dec. 13, 2010. It is now operational. Here are some results from testing the camera.
Leonids (2010)[edit]
A series of images were taken during the morning of Nov. 18, 2010 for the purpose of testing the sky camera. This was the night of the Leonid meteor shower. Learn more at 2012 Quadrantids.
Quadrantids (2011)[edit]
Another series of images were taken during the early morning of Jan. 4, 2011 during the Quadrantid meteor shower. There was a large amount of water vapor in the atmosphere. The camera is very sensitive to moisture due to the near infrared filter. Learn more at 2012 Geminid Meteor Shower.
Recent activity[edit]
The image at right is an experiment in incorporating real-time data in a learning resource. A bot automatically uploads a new image and updates the image caption once per day. Check back to tomorrow to see a new image. See the test page at Mu301Bot/nelm for more information.
Depending on the local weather the image might be overexposed due to thick cloud cover or it might show stars. A complete list of uploaded images can be found in the image file history.
See also[edit]
External links[edit]
- Sky Camera
- Sky brightness monitor
- The dark side of the Moon (Measurement of sky brightness during the total lunar eclipse of Sept. 27-28, 2015.)


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Ambitious Durham have clinched the signing of world class batsman Herschelle Gibbs as one of their two overseas players for next season.
The prolific South Africa opener will replace Martin Love, whose appearances this summer have been limited due to injury and Test call-ups.
And Durham, still in the hunt for promotion in the county championship, could make it a double scoop by re-engaging Pakistan paceman Shoaib Akhtar.
Initial talks have been held with the Rawalpindi Express but any deal is unlikely to be concluded until the world's fastest bowler returns from the two forthcoming Tests with Bangladesh.
Gibbs, meanwhile, has established himself as one of the leading batsmen in the world and has already made his mark in the present Test series in England.
The 29-year-old hit a magnificent 179 in a record breaking first-wicket stand of 338 with Springboks captain Graeme Smith in the drawn first Test at Edgbaston.
The Western Province strokemaker then hit 49 in another three figure opening partnership as the Tourists romped to an innings and 92-run victory over a shell-shocked England in the second Test at Lord's.
Hard-hitting opener Gibbs has scored over 3,000 runs in Test cricket, hitting nine centuries and 11 fifties at an impressive average of 45.
He has also impressed during his 135 one-day international appearances where he has scored 4,443 runs at an average of 35.
But the colorful star has been no stranger to controversy and was suspended for six months after he was charged with "criminal conspiracy" by the Delhi Police in 2000.
Gibbs had become embroiled in the late Hanse Cronje's infamous match-fixing scandal but remained typically philosophical about his enforced lay-off.
"I loved it," he said. "I played golf virtually every week and it wasn't a difficult time for me.
"I'm a happy sort of guy and I don't get down about things that don't go my way."
Durham have been trailing Gibbs for the past fortnight and coach Martyn Moxon is delighted to have beaten off the challenge of other interested counties.
"Having a batsman of Herschelle's ability in the ranks is an exciting prospect," said Moxon.
Both Gibbs and Shoaib - if he signs - will only be available until August due to the ICC Tournament which will force Durham to find replacements in the later stages of the season.
The Riversiders, meanwhile, will look to improve their promotion prospects over the next four days when they take on rivals Glamorgan in Cardiff.