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The Molalla River School District had a total of nine snow days over the past two months. Last night, the School Board approved a plan to make up lost days. The revised calendar restores six instructional days for students and extends the school year by two days.
Molalla River students will be in school until Friday, June 16
Teacher work days have been moved or eliminated to make room for instructional days
K-8 conference days will become school days on March 15-16
The high school conference day will become a school day on May 5
Late start Fridays in May will become regular start days
Eliminating spring conference days is not an easy decision. We value these key opportunities to communicate with parents. Yet, at this point, recovering instructional time is our highest priority. Note: June report cards will be mailed home after the grading day on Monday, June 19.
Despite the winter weather's impact on our schools, students, and families, this multi-faceted approach restores our instructional momentum and rhythm. We appreciate the flexibility and dedication of our employee groups, District leadership, and our School Board to come up with a solution that serves the students of the Molalla River School District
Phase 2 Modified 2016-2017 School Year Calendar


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Tigers-Rangers Preview
Roy Oswalt looked very comfortable in his Texas Rangers debut last week.
He's looked similarly at ease when facing Prince Fielder and Miguel Cabrera.
Though he has plenty of experience with those Detroit sluggers, Oswalt will pitch against the Tigers for the first time Wednesday night as he tries to help the Rangers capture their sixth straight series.
Texas (46-29) signed Oswalt (1-0, 1.35 ERA) to a minor-league deal May 29 and he made his debut Friday a victorious one, giving up one run with six strikeouts over 6 2-3 innings in a 4-1 home win over Colorado.
"I won't tell you I wasn't nervous," Oswalt said after a 110-pitch effort. "If you don't have butterflies, you might as well get out of the game."
Although the right-hander has never faced Detroit (36-38), he has seen Fielder and Cabrera the most among Tigers hitters. Fielder is 5 for 36 with a homer and nine strikeouts and Cabrera is 3 for 15.
Fielder has a homer among three hits and has driven in five in the first two games in this series. The first baseman is hitting .375 with three homers, 17 RBIs and a 1.077 OPS over his last 19 road games.
Cabrera, meanwhile, was finally held in check in Tuesday's 7-5 loss, going 0 for 3 and being hit by a pitch. He's a career .372 regular-season hitter against the Rangers with 23 RBIs in 20 games in Arlington.
Any discussion of Texas offensively, of course, begins with Josh Hamilton.
The slugger, who leads the majors in RBIs (67) and slugging percentage (.656), appears to be finding his way out of a 4-for-24 slump entering this series. Hamilton went deep Monday and Tuesday after an 11-game drought, and he's 8 for 25 with four homers and eight RBIs in six games against Detroit this year.
The Tigers, who won 8-2 on Monday, are trying to avoid dropping a second straight series after winning their previous four. Detroit missed a chance to reach .500 on Tuesday for the first time since it was 18-18 on May 15.
Doug Fister (1-4, 2.72) will face the Rangers for the first time since winning Game 3 of last year's ALCS by allowing two runs over 7 1-3 innings in a 5-2 home victory. He's 2-3 with a 4.38 ERA in six regular-season starts against them, though he was hit hard in his lone outing in Arlington.
Fister is 0-3 with a 3.23 ERA in five 2012 road outings - all losses for Detroit.
Hamilton is 2 for 10 in the regular season against the right-hander, but Nelson Cruz (7 for 14), David Murphy (6 for 16) and Adrian Beltre (4 for 11) have all fared better.
Beltre is 14 for 25 during a seven-game hitting streak, going 4 for 8 in this series.
Wednesday could mark the big league debut of left-hander Martin Perez, the Rangers' top pitching prospect. Perez was recalled from the minors Tuesday and will work out of the bullpen.

subset: commoncrawl


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Practicing in the Appellate Courts is for the purpose of reviewing trial court judgments to correct of errors committed by the trial court, development of the law, achieve a uniform approach across courts, and the pursuit of justice, more generally. Appellate courts are not a forum to make a new case, but instead they determine if the rulings and judgment of the court below were made correctly.
Meno is a town in Major County, Oklahoma, United States. The population was 195 at the 2000 census. It was the previous home of Oklahoma Bible Academy.
Appellate Law Lawyers In Meno Oklahoma


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Using the "offers from" options you can filter merchants from regions which are most common in our database: the UK, Germany, Austria and Poland.
If a checkbox near a flag is selected, offers from merchants from that particular region will be displayed, otherwise they will not be visible.
If you select offers from "all regions", all offers from all merchants will be displayed. These incude offers from merchants in countries not listed here.
Material: hardwood Length: 17cm
Material: hardwood
Material: red wood
Material: hardwood hollowed body
Material: red wood hollowed body
Material: fibreglass
Material: rubber tree
Material: palisander Diameter: 1.7cm
Material: palisander Diameter: 2.7cm


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SMITHTOWN, N.Y. (CBSNewYork) – Officials in Smithtown are responding to complaints that a home is so littered with junk, it's an eyesore.
Charles Richie's property at 21 Heather Drive in the quaint Kings Park community is littered with piles of scrap metal, wood, and broken furniture.
Imagine being Carolyn Nedwick, his next door neighbor.
"We're embarrassed to invite people to our homes because inevitably when people come to our home, that's the topic of conversation. It's 'How do you live next door to this?'" Nedwick told WCBS 880 Long Island Bureau Chief Mike Xirinachs.


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Unfortunately, I haven't had a chance to see/check out any Le Creuset outlet stores, but I see on their website that there's a good number of them around. Just wanted to see if anyone has been to them recently- was it worth going to, or is it mostly random pieces in the unpopular colors? Particularly want to hear if anyone's been to the Leesburg VA outlet or any of the ones in NY/NJ, as those would be the ones that are most convenient for me.
I'm specifically in the market for my first dutch oven, so if anyone has any suggestions on what size to get, that would be greatly appreciated also! (I'm cooking for two most of the time, but is the 2 3/4qt. too small even for two?)
Sorry for rambling, and thanks in advance for any input!


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Hey Mama, I'm a thing now. So I'll be coming home soon. To be a thing Mama is to be concretized into a persona. I am the intellectual. I am the writer. I am the activist. I am most of what I've wanted to be growing up. Do you remember me telling you I wanted to change the World? Do you remember when Daddy told me that changing the World is changing the Worlds around you? The little ones? Neighborhoods? Your peers? Do you remember when I used to say I wanted to be "the flyest and the wisest?" Well Mama, I've done it. I've changed people. It hasn't been much, some of it has been for the worse, but it's been enough for people to see me differently. People see me differently than I do. I do not see me as a thing. I do not see me as an intellectual. I do not see me as an activist. I do see me as a writer. But this is only because I think I was born a writer. I have always been a writer. You've made me a writer.
But the rest of this is new. I do not know what they mean what they say I have power. Well, I know I have power in the sense that I am a man. Men always have power. The World is a Man's World and I would like for that to change. But until it does, I know that I carry the structural sin of Manhood, of patriarchy, of cisheteropatriarchy. But I believe that the conversation, the critique, around my power is an extension of this structural sin. I am not wrong because I am a Man who innately holds power in a patriarchal structure. I am wrong because I am a Man who innately holds power in a patriarchal structure who has additional power in this movement and who is utilizing this power unethically. I did not know I had this power Mama. I did not know I was a thing now. But I do know that whatever this is has caused more harm than I am willing to let continue. And that's why I'm coming home. I'm not coming home to escape the conversation, the critique; I'm coming home because at home I am nothing. I do not like to think that I matter to people who I do not know. I do not like to have expectations that exceed yours. I often tell myself "As long as my mom's proud of me then I can't be wrong." But this is no longer true. I am not only accountable to you. I am accountable to so many more people. I am accountable to a whole entire World. I am accountable to a whole entire World outside of you.
You're a Man now, boy. You're a Man now, boy.
But that's why I'm coming home. I'm coming home to be a boy for a bit. To take a break from being a Man, from having to understand myself as a structural sin, from having to come to grips with the fact that I have access to movement power. I'm coming home because home is somewhere lodged between the throat of simple normalcy and momentary refuge. Home is where my innocence still has cognizance and stability is as normalized as the constant refrain of "John John." I'm coming home because I want to be "John John" this weekend. I want you yourself to tell John John that you're a man now, boy and although you are a man, you'll always be my boy. I want you to tell me that I could always stop being a part of this movement and you could still be proud of me. And I know that you will. But I also know that you'll encourage me to find home in a home that is never home, to find home in the homelessness of this movement, to find home in a home that is still not now, to find home in a home that is still a somewhere, to find home in a home still to come.
Mama, I'm a thing now. So I'll be coming home…. to know if I should find a home in my thingliness. To know if I can always consider your home, my safe haven. To know if I can always consider your home, my home, when my new home is too homeless feeling to be considered mine. Mama, I'll be coming home soon.


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Labview Quality Control
Summary of the Post:
Page1: Introduction on what is intended to do
Page2: Components used
Page3: necessary Hardware
Page4: Software explanation
All the files can be found here on Github.
This is the project I performed in the University of Regensburg. The course was an intensive course and took 2 week on Winter holidays. I am a fan of this kind of course because in 2 week you get deep enough in touch with a new technology. Personally I have taken 3 different courses. Labview (Pc- messtechnik), web development (HTML5, CSS3, JS,Jquery) and C#.
The purpose of the Project is building a production line which detects the quality of a specific piece. The line is always running and recording objects, then this objects are classify depending if they are in a good state or not.
The program has a pattern object without defects. When an object come through the line, a sensor of presence set an ON signal. Then the camera compare the pattern with the actual object. In case the actual object is in a good condition the object will be classified in the good state box, if not, the stepper motor will turn to the other direction and will be classified in the bad state box.


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Forgot your password? Enter the email address you signed up with and we will send you a link to create a new password.
Your password reset has been submitted to the address provided.
Words, letters, and/or numbers in stylized form
providing information and analysis in the fields of color for fashion by means of an interactive website
Business in Laguna Niguel, CA


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Fitness is not just one thing. It encompasses things like workout routines, dieting, gyms, and more. The list is large of things related to fitness that you can do to increase your total health and wellness. The following article offers advice on how you can make fitness work for you.
You should not lift weights for more than an hour at a time. On top of that, your muscles start to deteriorate after about an hour of work. Power your lifting workout down after an hour.
It's important to strengthen your thighs in order to protect your knees. A ligament tear behind the kneecap is a frequent sports injury that can create life-long issues. Stretching and warming up before strenuous exercises like running or strength training will keep your knees pliable and less prone to injury. Examples of exercises to accomplish this are leg extensions along with leg curls.
Having a solid core is imperative. Having a stable, strong core helps with balance and any other exercise you do. Doing sit-ups is an easy and cheap way to build your core. Sit-ups require no special equipment and you can do some reps virtually anywhere, which means you can squeeze in a few sets throughout your day. Not only will sit-ups increase your strength, they also help you to remain flexible. Develop your abs correctly and you will improve your overall health and fitness levels.
Most people need to feel or see the results of weight loss to stay motivated to continue. As a way to check progress, don't let the scales tell the story. Instead have some slightly snug fitting outfits handy. If you try the clothes on weekly while you are dieting, you will have physical evidence of the positive changes you are making in your life.
Clean each machine and piece of equipment in the gym before you use it. There could be bacteria and germs that other people have left behind on the equipment. Cleaning machines before you use them will help you to stay healthy, and avoid commonly transmitted diseases like the a cold or the flu.
In order to improve the mass of your quadriceps, perform box squats. You will get better results by doing box squats which will help you with regular squats. You will need to stand in front of a sturdy box. Perform the squat you would normally, but pause while about to sit on the box.
Trying doing some donkey calf raises in order to build up the muscles in your calf. This exercise is very effective. You must have a buddy willing to rest on your back so that you are free to lift your calves upward.
Only gently workout the muscles that you had exercised the day before. This is an easy way to work on muscles that are tired expending very little effort.
Try to press your tongue against the top of your mouth during crunches. By keeping your tongue in this position during an ab routine, you will use your neck muscles, which keeps your body aligned correctly. You will avoid injuries and strains.
After a workout, you should feel great and rejuvenated, not tired or worn out. Your exercise routine should include a cardiovascular component through jogging or other aerobic exercises. You also need to incorporate exercises which strengthen the muscle groups throughout your body.
A great exercise routine is to use barbels and dumbbells on a workout bench. Picking just the right bench can really help to make your workout powerful. If you can feel the support structure underneath the padding, you should switch benches. A bench without proper cushion can damage your spine while exercising.
Do your exercises in a particular order. Begin by working with dumbbells, grab the barbells next, and the machines can be your final stop. Weight lifting guru's will tell you that you work your smaller muscles more intensely with dumbbells causing them to tire much quicker than your larger muscle groups. When your muscles become fatigued you need to move to machines that will require you to use small groups.
Look for companies that have free access to gym equipment. Oftentimes, companies offer their employees free access to equipment. Whatever you choose, having a gym that is easy to access is important for your fitness goals. The closer to the gym you are, the more likely you are to go to it, rather than not.
Fitness activities can be incorporated into your daily routine. It's possible to add a few five or ten-minute activities into your day without interrupting your schedule. If you have too many activities in a day with no time for fitness, you are missing out on some useful fitness-boosting time. You can use downtime for fitness time.
Do not just work out one part of your body. Some people think that if they focus on one part at a time they are doing something good. But instead of getting better results, you're actually increasing your risk of injury.
In order to increase muscle mass and completely change your body, strength training is a must. Strength training builds muscle mass and the more muscle mass you have, the more calories you burn, even while resting. Just remember to rest muscles a day or two after you workout.
As you can see, fitness is an extensive subject. While there are certain things that must be avoided -or included- in any routine, there are just as many things that can be customized to meet your needs. Hopefully, this article provided some guidance so you can become fitter.


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Data Breaches : Let Magnus cut your residual risk by 1000X
The Verizon 2016 Data Breach Investigations Report (DBIR) is out, and the news is still bad, just like last year, the year before, and the ten years before those years. The DBIR states that 63% of data breaches in the past year involved weak, stolen, or default passwords. Notable too, the top attack pattern aimed…Details


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The most important issue in this election is the economy and jobs. Unfortunately, President Obama has demonstrated time and again a fundamental misunderstanding of how the economy works, the sources of its problems, and how to restore rapid growth. The question voters need to answer between now and Election Day is, if things continue on their current course, will you be better off in the future? If the answer is no, you should vote to change course.
The economy today is stuck in malaise.
About one-fifth of the workforce today is unemployed, under-employed (i.e., working part-time rather than full-time), or has stopped looking for work.
The median household income has fallen by $4,000.
The economy has created about 400,000 more jobs than it has lost since the president's inauguration.
Average annual GDP growth since 2009 has been 1.5 percent, compared to the post–World War II average of 3.3 percent.
America deserves better, and past presidents have succeeded where President Obama has failed. Under President Reagan, for example, the U.S. confronted a severe recession in 1981–82, where unemployment soared to 10.8 percent. But in 1983, unemployment dropped 2.5 percentage points and GDP growth was 4.5 percent. In 1984, Reagan's reelection year, unemployment fell another 1.1 percentage points while GDP soared to an eye-popping 7.2 percent. Meanwhile, GDP growth in year three of the Obama presidency was 2.4 percent, and so far this year it has been a paltry 1.7 percent.
The difference lies in economic policy. President Reagan sought to lower government barriers to private-sector production and to encourage economic risk-taking. His policy mix was to cut tax rates, to strengthen and stabilize the dollar, and to reduce stifling regulation. The boom of the 1980s, after the disastrous stagflation of the 1970s, is one of the great success stories in economic policy.
Now consider President Obama's policy approach.
Taxes: The president's insistence on raising taxes sharply on many small businesses and investors, despite high unemployment, hangs like a Sword of Damocles over the economy and runs counter to every major school of economic thought from Keynesian to supply-side to Austrian. The president's refusal to make a bipartisan deal to lower the corporate-tax rate — the U.S. rate is the highest among developed nations — confirms his lack of interest in reducing tax rates.
Obamacare: As the U.S. Supreme Court confirmed this summer, Obamacare amounts to a $1.7 trillion tax increase over a decade, much of it on lower- and middle-income Americans and small companies. No wonder employers have been slow to hire new workers.
The dollar: President Obama has presided over a substantial dollar decline against gold and other commodities, and a highly unstable dollar relative to other major currencies. The volatile dollar distorts investment, reduces business confidence, and hampers international trade.
Dodd-Frank: The massive financial regulation bill contains a blizzard of new regulations and costs for banks, most of which have nothing to do with the issues that led to the mortgage bubble and financial crisis, and it does nothing to resolve Too Big to Fail. Due to rising compliance costs from Dodd-Frank, consumer bank fees are rising.
Other regulation: On top of Obamacare and Dodd-Frank, additional Obama-era regulations from agencies such as the Environmental Protection Agency and the National Labor Relations Board have increased costs for businesses. According to the Heritage Foundation, the total cost of regulation from the first three years of President Obama's presidency is five times greater than the comparable period under George W. Bush.
Energy: The Obama administration has reduced substantially the number of oil and gas drilling permits issued, restricting energy production from Alaska to the Gulf of Mexico, while increasing regulation on the coal industry. The president's decision to block the Keystone XL pipeline not only hurt domestic workers but made the U.S. more dependent on oil from hostile nations. Meanwhile, Mr. Obama's subsidies to green energy companies have yielded little in the way of new technology but have created costly boondoggles such as Solyndra.
Debt: The president's only real approach to economic growth is government spending. His $800 billion stimulus failed to spur a strong recovery, and the total national debt has soared to $16 trillion from $10 trillion on his watch. Yet, the president now proposes significant new spending in his second term on "nation building" at home, i.e. more government workers and increased dependency on government in place of a growing private sector.
On crucial budget issues such as entitlement spending, President Obama has been worse than AWOL. We know thanks to Bob Woodward's new book that the president blew up budget talks with Republican leaders; he has ignored his own Simpson-Bowles debt commission; and he has allowed his party in the Senate to go three years without passing a budget.
In sum, rather than take the proven path to economic boom — the path of Reagan, as well as Jack Kennedy in the Go-Go 1960s and Calvin Coolidge in the Roaring '20s — that reduces the cost of work and investment, President Obama has willfully added huge new costs and red tape on business, proposes a major tax increase starting on January 1, and has presided over a highly unstable dollar.
One approach works; one doesn't. We can do better.
— Ted Cruz is the Republican candidate for the U.S. Senate from Texas.


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Glenn's Auto Repair
Review for Glenn's Auto Repair
Christina I. on 07/23/2012
"Headlights fixed - check!"
As usual, I was in and out of there in no time. The service was friendly, affordable, and professional. I'm so glad I have somewhere I can take my car and know it's being taken care of. Thanks, Glenn et al!
Vehicle: Mazda Protege5
Service Date: 07/20/2012
Review Created: 07/23/2012 12:49 PM


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Pilgrim Heart: The Way of Jesus in Everyday Life
About the Book
Pilgrim Heart: The Way of Jesus in Everyday Life
The faith of Jesus was once considered a distinctive way of life rather than a complex theological system. PILGRIM HEART re-visions discipleship as—first and foremost—a particular way of life guided by a set of simple but powerful daily practices known to the earliest disciples and saints throughout the ages. These include friendship, Sabbath rest, hospitality, confession, forgiveness, listening, discerning, singing, creating and experiencing the arts, and telling stories.
Darryl Tippens—author, speaker, and professor of English literature for over three decades—is the Provost of Pepperdine University where he also serves as professor of English literature. His newest book, PILGRIM HEART: The Way of Jesus in Everyday Life (Leafwood Publishers),invites Christians to consider afresh the way of Jesus in light of thousands of practices that have proven to transform lives for two thousands years. Darryl communicates these insightful truths in a style that is both scholarly and accessible. The result has been recognized as a Christian classic in the making. "This incredible book belongs on the shelf right next to Richard Foster and Dallas Willard," raves author and pastor Mike Cope.
People today are hungry for a holistic spirituality that involves heart, mind, and body. This important new book seeks to reconnect Christians to a dynamic, living tradition of spirituality. "A follower of Jesus is a pilgrim, literally one from a foreign land, an alien, a traveler. True spirituality is never sedentary. The language of pilgrimage permeates the literature of Christian spirituality," Darryl states. "It's a general theme of the Bible that people of faith are travelers at heart:Abraham and Sarah, of course, but also Moses, the people of Israel, and the followers of Jesus. Moving toward God requires pilgrimage." Drawing from Biblical examples, church history, and the ideas of Christian thinkers including Augustine, C.S. Lewis, and Henri Nouwen, Darryl presents readers a compelling challenge to abandon their sedentary faith and pursue the literal process of following Jesus and learning his ways.
The inclusion of some unexpected spiritual disciplines (singing, hospitality, feasting, and storytelling, for example) is certain to inspire a fresh evaluation of current church practices. Darryl emphasizes, "A Christian community can inadvertently will its own death. No matter how well we might have 'done church' a generation ago, it matters little if we do not continually create the kind of compelling culture…that will ensure the propagation of communities of faith in our time as well. A community without the ability to regenerate is, by definition, terminal."
Addressing a church shaped by the American ideals of individualism and self-reliance, Darryl presents a convincing case for the lost art of living the Christian life in community with others. "Following Jesus is not a solo enterprise," he muses. "From the beginning, Jesus meant for us to go together, and church is a name for the group of people who follow Jesus together." Darryl envisions the church radically changed when its members truly become companions on the Christian journey. PILGRIN HEART delivers a powerful message that will inspire Christians to live a life that accurately mirrors the lives of Jesus and his followers, a life that is completely transformed.
Pilgrim Heart: The Way of Jesus in Everyday Life
- Publication Date: May 2, 2006
- Genres: Christian, Religion, Spirituality
- Paperback: 224 pages
- Publisher: Leafwood Publishers


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Google announced its self-driving car project in 2010 to make driving safer, more enjoyable, and more efficient. Video shows Steve, who joined us for a special drive on a carefully programmed route to experience being behind the wheel in a whole new way.
Music: The Album Leaf - "We Need Help"
[Video] Your UTA at Work: Paratransit Bus Operator
[Video] Perkins School for the Blind - Bus Stop Challenge
[Video] Wayfindr: Using smartphones to guide vision impaired people in subway
[Video] Xian Horn describing her life and disability - AT&T and NYU Connect Ability Challenge
[Video] Jason DaSilva describing his life and disability for the AT&T and NYU Connect Ability Challenge
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Online Class
Crochet: Basics & Beyond
with Kim Werker
I adore this bag and now take it everywhere! The Granny Stripe Messenger Bag works up super quick. This hip, stylish, functional bag is perfect for everyday use. Wanna line your new bag? Followed this amazing free tutorial found at Future Girl http://www.futuregirl.com/craft_blog/2008/10/tutorial-sew-a-lining-into-a-crocheted-bag.aspx. It's easy! I promise. BASIC SKILLS NECESSARY Basic Crochet Stitch Knowledge and Working in Rounds GAUGE Laying flat, rounds 1 and 2 measure 2 1/4 inches. SIZING / FINISHED MEASUREMENTS Approximately 16" Wide and 9" Long, Strap measures 36" and can easily be adjusted up or down.


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The Department of Materials Science & Metallurgy is committed to learning within the field of science and technology. The selection mentioned below are representative of the activities organised within the Department.
- Residential science courses for prospective (Cambridge) students
- Web-based teaching resources
If you are looking for undergraduate admissions information please look on the Cambridge Admissions Office website and visit out UG Study tab to find out more about Materials Science at the University of Cambridge.


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Taipei, tainan, kaohsiung dan tempat lainnya. back to ina 31/05/2013
Need my help? just contact me!
Do not make direct payment to traveler, use SafePay as mediator for protection. Low fee, safe and easy to use. You will get reputation at the end of the SafePay - how it works
Jakarta - Taipei
Jakarta - Taipei
Friday 01 December 2017
See all 4


text: Well the obvious difference is clearly the four corner UI.. which doesn't seem like Android at all, but is quite clever and useful. I prefer the ADW launcher, because I felt that the default UI didn't really give the feel of Android. Also, how deeply has the system been tweaked? As in, many Android handsets can be rooted and highly customised, although the X10 Mini cannot load ROM's, due to having no apparent recovery mode, which means custom system files cannot be flashed due to system files already being used (obviously as the phone is running). So does anybody know how different the X10 Mini's Android setup is from most other handsets?


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February Intensive Registration NOW OPEN
The February 19-13 intensive is OPEN today for registration. Grab your spot soon, as I have several folks already signing up, and there's a 15-person limit. If you know me …
Authors, launch your books!
Disclaimer: We won't share your data. We are not Darth Vader.
Our editors can teach you a ton in just a few pages. Send them 3 pages of your staggering work of genius, and they'll evaluate your writing. Click here to book our nonfiction and fiction mentors.
You've written your book, so now what? How do you help it fly in a way that fits your personality and bandwidth? Click here to find products and tutorials to help you become a wise and effective launcher.
Through coaching programs (coming soon!), tutorials, and one-one-one mentoring, we will help you shape your book and launch it into the this crazy world! Click here for all the services we offer.
The February 19-13 intensive is OPEN today for registration. Grab your spot soon, as I have several folks already signing up, and there's a 15-person limit. If you know me …
This short and sweet post highlights ALL my digital writing products. You'll get them all for a heavily discounted rate for one week. Yep, just until next Tuesday August 8th. …
Hi friends! Just a quick blog post to let you know that GO ASK MARY hasn't died. It's alive and well, but, my life has been caaarazy, and finances are …
Mary DeMuth knows how to write. Mary knows publishing. Mary knows marketing and promoting, especially in social media. Mary knows how people think. Put that all together and Mary is one amazing coach/consultant for any author seeking to start a book promotion. Get her in the conversation early. She's really good at what she does.
Mary DeMuth is a rare find: a truly generous and understanding mentor in the field of publishing. From her personal experience and knowledge, she effectively guides writers through the confusing, emotional, and rigorous path toward launching their creation. I'm so indebted to her.
Mary DeMuth's experience, creativity and tenacity are a dynamic combination. For over a decade, she's been generously pouring in to aspiring authors. To have access to this kind of expertise is not-to-be-missed!
When you're seeking to publish a book, it's important you don't proceed wearing rose-colored glasses. (Besides it's hard to see the computer screen with shades on!) It's your job to know the business, to be wise as you consider the journey, and count the cost as you publish your staggering work of genius.
That's why it's important to be wise as you launch your book. Know the industry. Ask a mentor. Get some help!


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Frontier Sleigh by Streamridge - Ships in Canada Only
DIY - Feed Your Feathered Friends
Either for yourself, your kids or kids that you want to gift, these Urban Birdhouses by Dululu are a great - and educational - gift idea.
Made of Canadian Birch, you can colour and assemble and decorate these outdoor birdhouses. You do not need glue to assemble these houses, but some decoration items (included) may require wood glue.
Dimensions 12'' x 4'' x 4''.


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The Ben Lange campaign is targeting Bruce Braley's voting record and spending decisions in a newly released web ad entitled, "Enough is Enough."
The ad highlights the severe fiscal outlook facing the U.S. Government and the recent policies which have exacerbated our fiscal challenges. It includes statements from Adm. Michael Mullen, Chairman of the Joint Chiefs of Staff and President Obama's top military advisor, and David Walker, former U.S. Comptroller General, both concluding that the national debt is the most substantial threat to U.S. national security.
Lange's ad states that "Bruce Braley is part of the problem," and lists the policies that Braley has supported while in office, including massive federal deficits, bailouts for big corporations, takeovers of private companies, cap-and-trade, and Obamacare.
The ad concludes with 'ENOUGH IS ENOUGH,' and that it is time to send a message, it is time to put a check and balance on this administration and Congress, and it is time for a new generation of political leaders who will put principle before party.
The Lange campaign released a similar ad during the primary election and after thousands of views and frequent requests to re-release the ad by voters from across Iowa's 1st district, the campaign has overhauled and released an updated version.
Photo by Dave Davidson
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Germany Pulls Off Largest Evacuation Since WWII
The biggest evacuation in Germany since the end of World War II has gone off with barely a hitch. On Sunday about 65,000 residents living in a one-mile area of Frankfurt had to evacuate their homes while authorities defused an unexploded bomb, the BBC reports. The WWII-era British HC 4000 bomb was discovered Tuesday at a building site, and authorities said that an uncontrolled explosion could flatten a city street. Police made sure the area was clear by using heat-sensing technology, and noted a couple of stragglers may face criminal charges.
There are believed to be hundreds of thousands of unexploded WWII-era bombs in Germany. Officials believe about 15% of the bombs dropped on Germany during the war failed to explode, and many ended up buried deep in the ground.
Read the full story on Newser.com
- Germany, in Secret, Has Shepherded Half Its Gold Home
- Mother Exhumes Baby's Coffin and Finds It Empty
- Madonna Is Moving to Portugal


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Demi Lovato has been on tour with Nick Jonas for the "Future Now" show. They made a stop in Washington D.C. and added a little country to their pop show when Demi invited Brad Paisley on stage to sing their duet "Without a Fight".
Demi Lovato slays this song and all the high notes in it. Here's what Brad Paisley has to say about that,
"I think she can hit notes that we can't hear," Paisley says of Lovato, calling her voice "otherworldly." "It's hard to have character when you can sing that high. But she does."
Brad and Demi Snapchatted before the show together. Looks like they have a lot of fun together!
Nice Demi! This is why I don't do snapchat. RT @lovatoliv: @ddlovato pic.twitter.com/QI4AOw8CXo
— Brad Paisley (@BradPaisley) July 26, 2016


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Freebie: Mmmm….Cupcakes
April 12th, 2008 in Freebie Posts
Cupcake week on Martha was the best. It inspired me to bake and use my cupcake courier that I won a couple years back. I went on their website www.cupcakecourier.com and they have more than one color now. You can store up to 36 cupcakes or take out the trays and store a fairly large cake.
I am planning on making these, the lady who came onto the show to make them has a great blog, www.bakerella.com
These are my all time favorite cupcakes to make, they were in a Martha magazine about 3 years ago and they are so much fun to make with kids.
Happy Cupcake Making!
Tags: cupcake, cupcake courier, halloween, martha


text: is relatively inexpensive, slim, and most importantly easy to get off. I have the Verizon High Gloss Silicone case. And while I love it, it is a royal pain to get off the phone (at least for me). I stopped using it like 6 weeks ago, and absolutely love a naked phone. My beloved Incredible, however, had a run in with a cement floor the other day, and I realized this phone is not meant to be bare. Problem is, I switch out my battery relatively often, so I really need a case that is easy to take on and off. Any suggestions, links, etc? I have plenty of "Thanks" to give, if you know what I mean.


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We recently demonstrated that postmenopausal women have an augmented blood pressure response to voluntary apnea compared to premenopausal women. Both obstructive sleep apnea (OSA) and healthy aging are associated with increased oxidative stress, which may impair cardiovascular function. Restoring physiological responses could have clinical relevance since transient surges in blood pressure are thought to be an important stimulus for end‐organ damage in aging and disease. We tested the hypothesis that acute antioxidant infusion improves physiological responses to voluntary apnea in healthy postmenopausal women (n = 8, 64 ± 2 year). We measured beat‐by‐beat mean arterial pressure (MAP), heart rate (HR), and brachial artery blood flow velocity (BBFV, Doppler ultrasound) following intravenous infusion of normal saline and ascorbic acid (~3500 mg). Subjects performed maximal voluntary end‐expiratory apneas and changes (Δ) from baseline were compared between infusions. The breath hold duration and oxygen saturation nadir were similar between saline (29 ± 6 sec, 94 ± 1%) and ascorbic acid (29 ± 5 sec, 94 ± 1%). Ascorbic acid attenuated the pressor response to voluntary apnea (ΔMAP: 6 ± 2 mmHg) as compared to saline (ΔMAP: 12 ± 2 mmHg, P = 0.034) and also attenuated forearm vasoconstriction (ΔBBFV: 4 ± 9 vs. −12 ± 7%, P = 0.049) but did not affect ΔHR. We conclude that ascorbic acid lowers the blood pressure response to voluntary apnea in postmenopausal women by inhibiting vasoconstriction in the limb vasculature. Whether ascorbic acid has similar effects in OSA patients remains to be prospectively tested.
At the physiological level, both obstructive sleep apnea (OSA) (Leuenberger et al. 1995; Somers et al. 1995; Zou et al. 2004) and voluntary apnea during wakefulness (Heistad et al. 1968; Hardy et al. 1994; Leuenberger et al. 2001; Khayat et al. 2004; Steinback et al. 2010) lead to a reduction in arterial oxygen saturation (SaO2), a rise in end‐tidal CO2 (EtCO2), and a surge in muscle sympathetic nerve activity (MSNA) (i.e., chemoreflex). This results in vasoconstriction in the limb and renal vascular beds, and the subsequent rise in arterial blood pressure (BP). A recent study from our laboratory indicated that postmenopausal women have augmented BP responses to voluntary apnea compared to young, premenopausal women (Patel et al. 2014). Attenuating the acute pressor response to apnea‐induced hypoxemia may be beneficial as transient surges in BP are thought to be an important stimulus for end‐organ damage in hypertensive OSA patients (Narkiewicz et al. 2005b). Further, reducing the high sympathetic drive that is present in OSA patients even during wakefulness could have clinical implications (Carlson et al. 1993).
Epidemiological studies have consistently demonstrated that OSA is more common in postmenopausal women than premenopausal women with estimates ranging from 4 to 47% (Dancey et al. 2001; Lin et al. 2008). Moreover, postmenopausal women have an almost fourfold higher risk of OSA, even after adjusting for several confounders such as age and BMI (Bixler et al. 2001; Young et al. 2003), which suggests menopause is an independent risk factor for the development of OSA. Accumulating evidence has shown that both OSA and menopause are associated with an increase in oxidative stress and impaired vascular function (Grebe et al. 2006; Moreau et al. 2007). Indeed, Moreau et al. (2007) found that postmenopausal (i.e., estrogen deficient) women have lower femoral vascular conductance at rest and this effect could be attenuated by acute intravenous infusion of ascorbic acid (Vitamin C), a potent antioxidant (Frei et al. 1989; Levine et al. 1996b). Our group has also shown that ascorbic acid infusion can improve physiological function in some (Gao et al. 2012; Muller et al. 2012) but not all (Muller et al. 2013a; Pollock et al. 2014) studies.
There are currently no data regarding how ascorbic acid affects the physiological responses to apnea‐induced hypoxemia in postmenopausal women. Therefore, we tested the hypothesis that ascorbic acid attenuates the pressor response to maximal end‐expiratory voluntary apnea (MEEVA) in estrogen‐deficient postmenopausal women (i.e., ascorbic acid would modify the efferent arm of the chemoreflex). Because we expected ascorbic acid to lower the pressor responses to apnea via inhibition of sympathetic vasoconstriction, we measured beat‐by‐beat brachial blood flow velocity (BBFV, Doppler ultrasound) as an index of vasoconstriction in skeletal muscle.
Design and subjects
This study used a repeated measures design, cross‐over design in which each subject received both saline and ascorbic acid infusions on the same day. The Institutional Review Board of the Penn State Milton S. Hershey Medical Center approved all study protocols and written informed consent was obtained from each participant.
Eight healthy postmenopausal women (64 ± 2 years, 59–73 years) were studied; each had been without menses for at least 1 year. This sample size was determined once the first four subjects had completed testing. Specifically, we determined that if the mean difference in ΔMAP in response to apnea between saline and ascorbic acid was 5 mmHg with a standard deviation of 4 mmHg we would need to enroll seven subjects to be able to reject the null hypothesis with a probability of 0.80 and a type 1 error of 0.05. All of the participants were normotensive, nonobese, nonasthmatic, and nonsmokers (Table 1). Their height (167 ± 2 cm), weight (64.3 ± 1.9 kg), and body mass index (23.1 ± 0.8 kg/m2) were within normal limits. Total cholesterol was 180 ± 6 mg/dL (range 149–203 mg/dL), high‐density lipoprotein cholesterol was 67 ± 4 mg/dL (range 53–83 mg/dL), and triglycerides were 65 ± 6 mg/dL (range 43‐94 mg/dL). Complete blood count values were all within normal limits and all subjects were in good health as determined by history and physical examination. None of the participants were taking hormone replacement therapy or any other medications. Some of the subjects took daily multivitamins but none were consumed on the morning of the study. All of the participants regularly engaged in physical activity (e.g., walking, swimming, volleyball, gardening) but none were competitive athletes.
The studies were performed in a dimly lit temperature controlled (22–25°C) human research laboratory with subjects in the supine position. All measurements were performed in the morning hours after a 24‐h abstinence from caffeine, alcohol, and exercise and the participants were in a fasting state (i.e., 8–12 h after their last meal). The subjects wore a high‐density tube lined suit (Med‐Eng Systems, Ottawa, ON, Canada) that covered the entire body except for the feet, hands, head, and both forearms. Neutral water (34–35°C) was perfused through the suit to maintain mean skin temperature at a constant level and ensure the obtained cardiovascular responses were reflex mediated (i.e., not confounded by ambient temperature). Two intravenous catheters were placed by a registered nurse for the purposes of infusions (left arm) and blood sampling (right arm). Subjects were outfitted with several physiological monitoring devices (see below), practiced the breath hold procedures to ensure they performed expiratory breath holds as previously described (Patel et al. 2013, 2014) and then rested quietly for 15 min prior to baseline hemodynamic measurements and blood sample 1. Figure 1 displays the procedures. Note that ascorbic acid was always infused second since it remains in the body for several hours after a high‐dose infusion.
After baseline measurements were obtained, 100 mL of normal saline was infused over 20 min and then the infusion rate was lowered (20–30 mL was infused over 60 min). Blood sample 2 was then obtained. The subject performed one MVEEA in room air and only HR, BP, and SaO2 were measured during this trial. After a 10 min rest period, the subject was outfitted with an oronasal mask for the measurement of minute ventilation (MV) and end‐tidal CO2 (EtCO2). Seven minutes of room air breathing occurred as HR, BP, SaO2, BBFV, TV, and EtCO2 were obtained. At the end of the seven minutes, subjects performed a MVEEA. Following a 10 min rest period, ascorbic acid was infused as a loading dose (45 mg/kg in 100 mL of saline) over 20 min. Prior studies in our laboratory have shown this dosing paradigm to alter reflex cardiovascular responses to stress (Muller et al. 2012). A third blood sample was obtained and the ascorbic acid was infused at a lower rate for the remainder of the study (15 mg/kg in 33 mL of saline). Identical MVEEA procedures were repeated during the ascorbic acid infusion. At the very end of the study, a fourth blood sample was obtained.
Physiological measurements
Beat‐by‐beat BP was measured by photoplethysmography (Finometer, FMS) and HR was measured by 3‐lead EKG (Cardiocap/5; GE Healthcare, Waukesha, WI). MV and EtCO2 were determined on a breath‐by‐breath basis with a respiratory gas monitor (Ohmeda RGM 5250; Ohmeda, Bloomfield, CT). SaO2 was measured by ear oximetry (~3 sec delay). Inspiration and expiration were continuously monitored with a pneumobelt which also allowed for offline analysis of apnea onset and offset. Resting brachial artery BP was obtained in triplicate by an oscillometric device (Philips SureSigns Vs3; Philips, Andover, MA).
Beat‐by‐beat blood flow was measured in the brachial artery by Doppler ultrasound (GE Vivid 7; GE Healthcare). A 5 MHz linear probe was placed over the left brachial artery (medial to the left biceps brachii) with an angle of insonation <60°. Mean BBFV was measured in pulsed Doppler mode and velocity waveforms were synchronized to a data acquisition system (PowerLab, ADInstruments, Colorado Springs, CO) by a Doppler audio transformer (Herr et al. 2010). Our ultrasound device is not capable of recording simultaneous velocity and diameter measurements, therefore we remained in Doppler mode during the duration of the apnea. We recently demonstrated that brachial diameter does not change in response to MVEEA (Patel et al. 2013). Moreover, test–retest reliability is moderate to strong for ΔMAP, ΔHR, ΔBBFV, breath hold duration, and O2 saturation nadir in response to MVEEA (Cronbach's alpha ranged from 0.81 to 0.94) (Patel et al. 2014). Arterial diameter measurements were made at rest and forearm blood flow (FBF) was calculated as cross sectional area × mean BBFV × 60 to express in units of mL/min.
Venous blood samples were drawn at baseline and sent to Penn State Hershey Medical Center clinical laboratory where standard procedures were used to measure complete blood count, high sensitivity C‐reactive protein (hs CRP), fibrinogen, apolipoprotein B (Apo‐B), and a standard lipid panel. Following the infusion of saline and ascorbic acid, high sensitivity C‐reactive protein (hs CRP), fibrinogen, and Apo‐B were again quantified (Table 1). Apo‐B was chosen instead of a standard lipid panel for these repeat measurements since ascorbic acid dramatically influenced our pilot results (n = 4), likely due to interference in the measurement assay.
Data collection and statistical analysis
All data were collected at 200 Hz using PowerLab (ADInstruments, New Castle, Australia) and were analyzed offline. The FBF, MV, and EtCO2 were only measured at baseline (i.e., prior to apnea). We quantified the duration of the MVEEA, lowest O2 saturation, HR, MAP, and BBFV. Forearm vascular resistance index (FVRI) was calculated as MAP/BBFV. We analyzed four different time points, detailed below:
Base: The last 20 sec prior to beginning the apnea.
Apnea 1 (A1): The first 3 cardiac cycles of the apnea after the subject had completely emptied their lungs (absence of lung inflation but no reduction in SaO2 relative to Base).
Apnea 2 (A2): The last 3 cardiac cycles before the subject inhaled (called the "asphyxic break point") at the end of the apnea (absence of lung inflation and a reduction in SaO2 relative to Base).
Recovery 1 (R1): The first 3 cardiac cycles after the subject resumed breathing.
To evaluate the effects of each infusion, paired samples t‐tests were used. Data are presented as Mean ± SEM and P values < 0.05 were considered statistically significant.
The postmenopausal women received a total of 3832 ± 120 mg of intravenous ascorbic acid during the study. The breath hold duration was similar following saline and ascorbic acid (saline: 29 ± 6 vs. ascorbic acid: 29 ± 5 sec, P = 0.679) and the O2 saturation nadir was also comparable (saline: 94 ± 1 vs. ascorbic acid: 94 ± 1%, P = 0.879). As shown in Table 1, ascorbic acid did not influence any of the blood markers that were measured. The FBF, MV, and EtCO2 at rest (i.e., the seven minutes prior to onset of MVEEA) were comparable between saline and ascorbic acid (Table 1).
As shown in Fig. 2, ascorbic acid blunted the rise in MAP at both A2 (P = 0.034) and R1 (P = 0.017) compared to saline but had no effect on HR (Fig. 2, middle). Ascorbic acid significantly attenuated the reduction in BBFV at A2 (P = 0.049, Fig. 2 bottom). In a similar way, the percent increase in FVRI at A2 was significantly less following ascorbic acid (2 ± 8%) compared to saline (28 ± 6%, P = 0.022). Taken together, the effect of ascorbic acid on the pressor response is partly due to attenuated sympathetic vasoconstriction in skeletal muscle.
When analyzing the trials in which no imaging was performed, ΔMAP at A2 was significantly lower under ascorbic acid (6 ± 1 mmHg) as compared to saline (10 ± 1 mmHg, P = 0.007). The ΔHR at A2 was also less under ascorbic acid (3 ± 1 vs. 1 ± 1 beats/min, P = 0.036). Both ΔMAP and ΔHR had moderate effect sizes (0.59 and 0.40, respectively).
The purpose of this study was to determine the effects of acute antioxidant infusion (ascorbic acid) on physiological responses to voluntary apnea in healthy postmenopausal women. Consistent with our hypothesis, acute infusion of ascorbic acid blunted the pressor response to voluntary apnea in postmenopausal women in part by attenuating the reduction in skeletal muscle blood flow. These findings may be clinically significant as repetitive surges in BP lead to end‐organ damage in OSA patients, and are an associated risk factor for coronary artery disease (Narkiewicz et al. 2005a).
We (Patel et al. 2014) and others (Owens et al. 1993) have previously demonstrated that postmenopausal women have augmented BP responses to sympathetic activation compared to young, premenopausal women. We believe that estrogen deficiency plays a major role in the observed responses. Specifically, estrogen deficiency may influence the transduction of sympathetic nerve activity into vascular resistance (Vianna et al. 2012), thereby contributing to an augmented BP response in postmenopausal women. Age‐related impairments in neurovascular control have been previously demonstrated by our group (Heffernan et al. 2013; Pollock et al. 2014) and others (Hogikyan and Supiano 1994; Dinenno et al. 2005). A common mechanism between aging and menopause is oxidative stress, defined as a disturbance in the balance between the production of reactive oxygen species (ROS) and antioxidant defenses. Along with aging, menopause is associated with heightened oxidative stress, as evidenced by reduced total antioxidant status in postmenopausal women (Hildreth et al. 2014). Recent evidence suggests that oxidative stress can directly impair vascular function in healthy postmenopausal women (Moreau et al. 2007; Hildreth et al. 2014) and young men (Fadel et al. 2012). The leading theory is that ROS can directly and/or indirectly decrease nitric oxide (NO) bioavailability (Forstermann 2010) resulting in endothelial dysfunction and a proconstrictor state (Kojda and Harrison 1999). The aforementioned studies examined postmenopausal women under resting conditions, but it is unclear how ROS influence physiological responses during sympathetic stress.
The major finding of the current study is that ascorbic acid attenuates the pressor response to MVEEA, a powerful sympathetic stimulus. By measuring beat‐by‐beat BP, HR, and BBFV, we determined the BP attenuation is partly mediated by blunted skeletal muscle vasoconstriction with ascorbic acid. Ascorbic acid acutely modifies vascular responses in various conditions associated with heightened oxidative stress such as aging (Taddei et al. 2001), peripheral arterial disease (Muller et al. 2012), and even coronary artery disease (Levine et al. 1996a). When infused at supraphysiological doses, several mechanisms of action have been proposed, including directly scavenging ROS (Frei 1999) and stabilization of BH4 (Forstermann 2010), with the end result being increased local NO bioavailability. In this study, the effects of ascorbic acid on the skeletal muscle vasculature are probably due to NO modulation in endothelial cells to indirectly alter forearm vascular resistance index. In the absence of ascorbic acid (i.e., low NO bioavailability), full expression of apnea‐induced peripheral vasoconstriction is seen resulting in high FVRI in the postmenopausal women we studied. However, with ascorbic acid, the increased NO bioavailability opposes the peripheral vasoconstriction resulting in blunted FVRI compared to saline. This is similar to the findings of others where ascorbic acid significantly increased muscle blood flow during continuous dynamic exercise (Kirby et al. 2009), and after moderate intensity plantar flexion (Wray et al. 2009). An alternative explanation is that ROS directly influence the carotid body under normal circumstances (i.e., either enhancing or suppressing the chemoreflex) and ascorbic acid blocks this process (Pokorski and Marczak 2003; Del Rio et al. 2010). While our data cannot identify a clear physiological mechanism, the data show that under ascorbic acid the vascular tone balance is tipped toward greater conductance due to less forearm vasoconstriction (Fig. 2).
In this study, ascorbic acid did not affect any relevant blood markers such as hsCRP (marker of inflammation), fibrinogen (marker of hemostasis), or Apo‐B (marker of lipids) in postmenopausal women. Hildreth and colleagues (Hildreth et al. 2014) recently found that C‐reactive protein decreased after ascorbic acid infusion in postmenopausal women. It is worth noting that the postmenopausal women in that study had a BMI of 27.6, compared to our study (23.1), which could explain the discrepancy given obesity is associated with increased oxidative stress (Moreau et al. 2007). While the inverse relationship between chronic serum ascorbic acid levels and fibrinogen levels is clear in epidemiological studies (Langlois et al. 2001; Wannamethee et al. 2006), there is little evidence of changes in fibrinogen or Apo‐B markers directly after acute infusion of ascorbic acid.
In the present study, we did not measure serum follicle‐stimulating hormone, estrogen, or progesterone, but rather assumed postmenopausal status based on the lack of menses for greater than 1 year. In addition, we cannot determine if the observed responses are due to aging or menopause since there is a tight association between the two variables (Hildreth et al. 2014). However, since each woman served as her own control, we do not believe this affects data interpretation. It is important to note that MVEEA is not a true OSA per se because it does not involve arousal from sleep or upper airway collapse (i.e., both of which engage the sympathetic nervous system) (Chouchou et al. 2013; Muller et al. 2013b; Dempsey et al. 2014). However, we believe there is similar underlying pathophysiology between MVEEA and OSA, allowing us to make useful comparisons between men and women (Imadojemu et al. 2002). Because we did not measure sympathetic nerve activity, it is unclear whether ascorbic acid inhibits nerve activity or alters alpha‐adrenergic responsiveness. We also administered ascorbic acid intravenously; thus both the afferent and efferent pathways of the chemoreflex could be affected.
The present study indicates that in postmenopausal women, acute administration of ascorbic acids blunts the pressor response to voluntary apnea in part due to inhibition of skeletal muscle vasoconstriction. These results extend the findings that oxidative stress contributes in part to augmented pressor responses in older postmenopausal women. Whether ascorbic acid has similar effects in patients with OSA warrants further study.
Conflict of Interest
There are no conflicts of interest.
The authors are grateful for the nursing support provided by Cheryl Blaha, Jessica Mast, Todd Nicklas, and Aimee Caufmann, and the engineering support provided by Dr. Michael Herr. Gratitude is also extended to Anne Muller for preparing the graphics for this study and to Dr. Lawrence Sinoway and Urs Leuenberger for clinical oversight and funding support. Finally, the authors acknowledge the administrative guidance of Kris Gray and Jen Stoner.
Funding Information
This work was supported by National Institutes of Health Grants P01 HL096570 (LIS), UL1 RR033184 (LIS), and UL1 TR000127 (LIS).
- Manuscript Received: March 25, 2015.
- Manuscript Accepted: March 27, 2015.
- © 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.


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Coastal Maine Popcorn opening store in Rockland
Rockland — Coastal Maine Popcorn Co. plans to open a new store at 371 Main St. June 1, according to owners Julie and Paul Roberts.
This will be their third location. The first store opened in Boothbay Harbor six years ago, and they have a second store in the Old Port in Portland.
"We have an arsenal of 70 flavors of popcorn on hand," Julie Roberts said April 21. Customers are welcome to try all of the different flavors at the counter before buying a bag. The popcorn is air-popped to be more healthy than oil popped, she said. All of the popcorn is popped in Boothbay and shipped to the other stores.
"It's kind of hard to buy a bag of dill pickle popcorn before you've tasted it," she said.
The most popular flavors are salt and vinegar and Maine maple.
The store will be open seven days a week, year-round. It will have about five employees, she said.
The owners considered other locations for their next store and were actually on their way to check out potential locations in Camden when they spotted the store front available in Rockland. Roberts said they have received an outpouring of support from the city of Rockland and people in Rockland for the new store.
They have been effectively marketing their business via social media (see facebook.com/coastalmainepopcorn for more information).
Courier Publications News Director Daniel Dunkle can be reached at firstname.lastname@example.com or 594-4401 ext. 122.
Very fun, best of luck!
This is great news! Small business is the backbone of our great state and I am grateful for the innovation and courage of its residents. While self employment is not for everyone, I think we are wise to encourage it as a means for our citizens to provide for themselves and family. I plan to stop in and purchase some popcorn when they open.


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Every Day in Tuscany Readers' Guide Frances Mayes About This Guide Celebrating friendship and the pleasures of life in a beloved corner of Italy, Every Day in Tuscany is a book that is meant to be shared. Gather your friends for a special readinggroup experience, feasting on the recipes as well as Frances Mayes's evocative reflections on the timeless beauty of Cortona. We hope that the following topics and questions will enhance your journey. Introduction In 1990, Frances Mayes made a daring decision to restore an abandoned thirteenthcentury villa in the lush Tuscan countryside. Approaching the twentieth anniversary of that life-changing experience, she began to write a sequel to her previous bestselling memoirs, offering a deeply personal narrative of the changes she has experienced since Under the Tuscan Sun and Bella Tuscany first appeared. One incident, in particular, becomes a touchstone for memory, forgiving, and surprise. The result is a captivating tour of renewal among the townspeople of Cortona as the seasons unfold. From the treasures of the garden to the enduring triumphs of Renaissance painters, Mayes writes of a place where beauty thrives. No longer a newcomer, she welcomes us back to her other homeland, where strangers become cherished friends, communities thrive by resisting the hectic pace of the modern world, and families honor their rich history. And always there is succulent cooking: a hearty seafood stew, a seasonal plum tart, and much more, in recipes captured in each chapter. You don't have to cross the Atlantic to relish the daily joys of Tuscany. Its enchanting hillside landscape and the vibrant people who inhabit it are brought vividly to life on the pages of Every Day in Tuscany, a book that beckons you to savor it again and again over the years—just as Frances Mayes has done in her twenty-year love affair with one of the world's most endearing locales. Questions for Discussion 1. Frances Mayes explores the process of "taking" a decision (rather than making one) and being taken by decisions as well. Italy, she writes, took hold of her and shaped her in its image. How has she been transformed by her second home over the past two decades? What impact has she made on the community of Cortona? What decisions have "taken" you in your own life? 2. In the opening pages of Every Day in Tuscany, Frances Mayes describes an unsettling dream she's had in which she must choose between her house, Bramasole, and her right arm. How does she grapple with her sometimes conflicting feelings about Bramasole? What spurs her to occasionally consider living without it? What makes our relationships to our homes very different from relationships with other material possessions?
3. From cold spring rains to the lavish scent of lemon trees at their peak, Mayes describes a community that is constantly aware of nature. Discuss the seasonal aspects of life in Tuscany. Is your life in tune with the seasons? What can we gain by listening to the natural world? 4. Much has changed on the world stage since Mayes's early days in Cortona. How do her Italian friends perceive her American identity? What are some of the cultural challenges of her expatriate life? 5. Discuss the many kinds of love that are captured in Every Day in Tuscany: between Ed and Frances; among their friends and family members; of place; and of life itself, in all its everyday joys. What does it take to bring more love into a life? 6. Mayes describes the economic factors she encounters in decisions large and small, and in the lives of those throughout Cortona. How does she measure "costs" (financial and emotional) as she and Ed prepare for the next chapter of their lives? How is security measured and defined in a world that is not driven by materialism? 7. What were your reactions as Frances and Ed discussed major renovations for Bramasole? Would you have simply replaced the roof, or would you have said yes to the extensive changes? To what extent is the imperfect state of Bramasole part of its charm? 8. Hospitality is a key component to life in Cortona. Does your community emphasize hospitality to the same degree? Why do you suppose this is so? Why is it revitalizing for Tuscan families to host many friends? 9. Every Day in Tuscany unfolds as a series of beautiful images and powerful memories. How did Mayes's voice as a poet shape the format of this book? How does it mirror the way life unfolds? 10. Mayes describes the threats she received after signing a petition against a proposed swimming pool near her property. What does this incident tell us about the encroaching modern world and Cortona's attempts to remain unspoiled? Compared to Americans, how do Italians handle resistance? What are the strengths and weaknesses of both approaches? 11. Mayes's memoir includes several recollections of threats and sorrows she and Ed have experienced in the United States and abroad. What does she offer as the best antidote to fear and tragedy? How have she and Ed created "safety" in their lives? 12. Discuss the children who visit Bramasole. What is Mayes's legacy to them? What aspects of life in Tuscany do you predict will remain unchanged for many generations to come?
13. As you read about Lucas Signorelli's works, what timeless aspects of his culture came to mind? Would he feel at home in Frances Mayes's Tuscany, just as she feels at home immersed in his art? 14. What universal truths did Mayes learn from Willie Bell? What aspects of a southern childhood does Mayes carry with her, no matter where she lives? What aspects of your childhood are forever part of your own identity? 15. Renewal and moving forward are primary quests in this book. What tactics and solitary pursuits described here might you adopt? 16. In addition to Under the Tuscan Sun, Frances Mayes's previous nonfiction includes Bella Tuscany and A Year in the World, as well as the illustrated books Bringing Tuscany Home and In Tuscany. Discuss the ones you have read. What are the constants in her life? At the same time, how do her books inspire us to constantly reinvent ourselves?
About the Author In addition to her Tuscany memoirs, Under the Tuscan Sun and Bella Tuscany, Frances Mayes is the author of the travel memoir A Year in the World; the illustrated books In Tuscany and Bringing Tuscany Home; Swan, a novel; The Discovery of Poetry, a text for readers; and five books of poetry. She divides her time between homes in Italy and North Carolina.
To purchase a copy of
Every Day in Tuscany
visit one of these online retailers: Also available as an Audiobook
Read by Frances Mayes
Published on Feb 26, 2010
In this sequel to her New York Times bestsellers Under the Tuscan Sun and Bella Tuscany, the celebrated "bard of Tuscany" (New York Times) l...


text: I've been paying some attention to how much Advil I'm taking, and I want to compare notes with some of my fellow geezers. I'm 49, BTW. Anyway, I find that I need to take two Advil with breakfast. This will last 36 hours or so. Then most of my tennis-related joints start to ache the following evening. I will hold out until the next morning, and then have two more Advil. Sometimes I'm able to go 5 days or so without any Advil, but I have no idea what leads to these Advil-free stretches. If I am really feeling something from tennis, I'll take two before I play and ice knees, wrist and elbow afterward. And if I'm actually hurt, then I will take 2-3 before playing and may need to repeat that day. How about the rest of you older players?


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The new MINI John Cooper Works Countryman.
BMW Group
The biggest and most versatile model in the MINI range now features the brand's most powerful engine to date. The new MINI John Cooper Works Countryman combines race track feeling and useful versatility, on and off the road.
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Define the term strength. Draw eight stations circuit training programme for upper body strength.
Strength is the most important motor ability in sports as it is a direct product of muscle contraction. We can define strength as "Ability to overcome resistance" and this resistance is of four types :(i) own body resistance, e.g., 100 m race, jumping.(ii) resistance of implement, e.g., throwing events like shot, javelin and discus.(iii) resistance of opponent, e.g., wrestling, boxing, judo, etc.(iv) frictional resistance, e.g., cycling, swimming.Circuit training programme for upper body strength. Other exercises for development of strength in upper body can be :(i) Over head press(ii) Pushing against a wall (iii) Crunches(iv) Shuttle run(v) Leg raise (13 cm above ground) (vi) Back raise(vii) Chest press(viii) Shoulder shrug etc.


text: Hi guys I am new here and i hope that will spend much time with you guys here on the forum. Right now i am unemployed for 2 months, have no money and (please God no) might become homeless (and im only 22) - well, its hard to find a job in london. I love Graphic design, its my passion and i want to do it for a living, after looking 2 months for a job i found a graphic design job ad and got very excited, i am beggin the God to at least get an interview Im a self-taught Graphic designer, ive started when i was 15 and my skill progressed over the years, I am trying Freelance at 99designs.com and so far won 2 contests (within 2 months on the website) Is it hard to get a Graphic Design job in a small office ? Do you guys think that the competition for the job will be big ? That job is basically my last chance, and it would be a Dream Job, and a Life changing (and life saving) great job ! Also could you guys give me your opinion about my folio ? : Profile for VarcanDesignsâ"¢ | 99designs (its just logo design's) So what do you guys think ? Cheers Varcan


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Celine Naughton: We parents must be tech savvy so bullied children know that they can turn to us
SOCIAL media has a lot to answer for, but are Facebook, Twitter and sites such as ask.fm primarily to blame for the increasing scourge of cyberbullying? What of the responsibility of schools to protect students online as well as in the classroom? Or should we be focusing our attention on politicians for failing to crack down on internet trolls?
Of course, we need a joined-up solution to a problem that is increasingly posing a clear and present danger to our children; but as parents, the very first port of call has to be at our own front door.
'Sticks and stones may break my bones but words will never hurt me' is no longer relevant wisdom in a world where text is the very tool of online vitriol. Only 10 years ago, we could protect our children from offensive behaviour in the playground once they came home from school, but now that social media has breathed new life into bullying, it is a 24-hour problem. The cyberbully can emotionally beat up your child at home, in Granny's house or during a sleepover with friends, and who's there to protect them then?


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Climate change is already causing harm to vulnerable people and will continue to do so. If we accept that mitigation and adaptation alone cannot avoid all the adverse impacts of climate change, this means that there will be some unavoidable consequences. This has led to the concept of 'loss and damage' appearing in global climate…
Author: Rob Byrne
About Rob Byrne
Rob has been working in the sustainable energy field for more than 15 years as an engineer, a project manager and, more recently, in policy analysis. He is particularly experienced in energy and development in an African context, having spent a total of five years on renewable energy projects in a number of countries (Botswana, Tanzania and Kenya). As well as his work in the STEPS Centre, Rob is a Research Fellow with the Sussex Energy Group in SPRU (Science Policy Research Unit) at the University of Sussex, and an Energy & Emissions Theme Coordinator in the Tyndall Centre for Climate Change Research. He also teaches at undergraduate and postgraduate level in energy, development and sustainability issues. Rob's focus is the role of science, technology and innovation in developing countries, particularly over the long term and in relation to efforts to reduce poverty.


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Thanks so much for visiting Rose Bakes! I hope you're inspired to bake a cake, decorate something fun, or try a new recipe! Sign up for FREE updates in your inbox or in your feed reader to keep up with all the latest things I'm sharing! Happy Baking!
Hollywood Red Carpet Cake Front
This site contains affiliate links which means that, at no additional cost to you, I may earn a small commission if you make a purchase. Thanks so much for your support in this way! Read my full disclosure policy here.


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Mumma Cat's Aquaorganic® Herbals
Who needs a little spice in their life? Try Mumma Cat's new range of Aquaorganic® chili flakes. Great for gifts; the little hotshots Devils Dust would look fantastic hanging on the Xmas tree! Get in early, limited numbers available.
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This feed is specially formulated for Australian Native Fish, is made for us only and available only from 1aquaponics.com, 1aquaponics.com.au, 1aquaponics.info, aquaorganic.com.au, aquaculture-advantage.com.au websites.
Protect your health and your investment with good nutrition and they will reward you with a stream of good quality nutrient in your aquaorganic® Food System. Your fish rely on you for quality of life and remember that their waste is feeding your plants so eventually you will be eating what they are eating. Better to be safe and know what you are feeding your fish!
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The Westin in Liberty Place
Philadelphia, USA
Client: General Growth Properties Inc.
Size: 216,000 sq.ft. (20,000 sq.m.)
The 216,000 sf Westin is a 290-room premier-quality hotel facility located in downtown Philadelphia. Designed by Zeidler Partnership Architects, this distinctive structure rises above a two-level retail podium and is a component of the prestigious Liberty Place Phase II project located on a 3.5 acre site bordered by Market street, Chestnut street, 16th and 17th Streets.
The hotel's porte-cochere was developed on 16th street with
a generous covered and well lit space to welcome guests
and allow for valet parking. Guests enter the ground level and proceed to the 3rd level sky lobby where there are views into the glass enclosed central Rotunda with its elegant boutiques and restaurants.
Special features of the Westin include superior marble and millwork nishes, luxurious suites, and a stunning 7,500-square foot ballroom. The exterior cladding of the hotel has won several awards for the quality of the pre-cast aggregate material
Zeidler Partnership was responsible for the master planning and design of the hotel, retail, parking, and loading components.
The rm was also responsible for the preparation of contract documents and contract administration of Liberty Place Phase II, including the office tower.
- American Concrete Institute, Delaware Valley Chapter) - Award of Excellence, Architectural Concrete/ Precast Claddings, 1992
- Precast/ Prestressed Concrete Institute - Design Award, 1992
- Architectural Precast Association - Award for Design and Manufacturing Excellence, 1991
- International Union of Bricklayers and Allied Craftsmen - Crafts Award, Best Project (Terrazzo) - The Shops at Liberty Place, 1991
- Precast/ Prestressed Concrete Institute - Design Awards, Honorable Mention, 1991
- Concrete Construction Committee of Philadelphia - Merit Award, Commercial Project, 1991


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Sherry FitzGerald O'Donovan are delighted to present Rowan View to the market. An exclusive development, consisting of 10 magnificent homes, offers luxury family living in a most enviable location.
These impressive properties are of concrete build design, constructed to maximise the generously proportioned living space and flood each area with natural light. With Ducon cast concrete floors between each level, the sound proofing is immense and the safety and security of the property is vastly enhanced. Every aspect of the design has been meticulously thought through and incorporates quality, style and elegance in every feature.
Available Units:
5 Bed Detached Houses (House Type A)
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6 Bed Detached House (House Type A with Basement)
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Prestigious development consisting of 10 exquisite homes
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Distinctive architectural design
Landscaped private and public gardens with decorative paved driveways
Generous PC sums allowed for all quality fixtures and fittings throughout
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Surrounded by picturesque country views and mature landscaping, this tranquil setting offers a peaceful retreat to its inhabitants, away from the hustle and bustle of city living. However, its close proximity to the Kinsale Road Roundabout and the South Link Road Network, allows for an easy commute to Cork City Centre and all of its environs.
These particulars are detailed for the purposes of representing the development only. Visual representations, finishes, layouts and/or scales may be approximate or representative of the development rather than exact specifications of the actual unit. The developer reserves the right to make alterations to the design and specification in the overall interest of the development.


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There may be a breakthrough in the lengthy labour dispute between Moncton and its transit workers.
The union representing locked out Codiac Transpo employees says its members will vote on a contract offer that had previously been rejected.
At Monday night's city council meeting, George Turple, the union president, told the city the membership will accept a deal that was previously rejected.
"What I'm prepared to do today is to call a meeting with my membership and recommend to them they accept a 2.75 per cent increase over the next five years," he said.
In recent negotiation attempts, the union asked for 4.3 per cent wage increase over five years.
"We don't see this as a concession because, as I just said, there was a lot of language changes and clawbacks that the city were looking for that we've been able to iron out," Turple said. "And in saying that, the majority has decided they could live with the 2.75 based on the language changes we were able to negotiate."
The new language includes agreements on health benefits, and part time versus full time employment.
No guarantees
The mayor said he was surprised by the union's move, and there are no guarantees the city will accept this deal, which was originally offered eight months ago.
"I would say that it's a positive move by the union," said George LeBlanc. "At long last they have made a move which I think brings us closer together."
Both sides will discuss the next steps at the negotiating table. The city said that will happen a week from now, on Tuesday, but the union is hopeful talks will resume sooner.
Turple said bus riders have suffered enough. Some riders spoke at Monday's council meeting, pleading for a resolution.
Recently, the city announced it would consider alternative transportation to help people get around Moncton during the winter months.
The lockout began June 27, and includes 90 Codiac Transpo employees.


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Thursday 30 May 1912
It was Thursday, under the sign of Gemini. The US president was William Howard Taft (Republican).
Famous people born on this day include Julian Gustave and Alexander Langsdorf.
Jupiter på jorden, directed by Georg af Klercker, was one of the most viewed movies released in 1912
But much more happened that day: find out below..
You can also have a look at the whole 1912 or at May 30 across the years.
Old Newspapers
Have a look at the old newspapers from 30 May 1912 and get them!
Which were the most popular movies released in the last months ?
Find out your future
Get a FREE Numerology report based on the digits of 30 May 1912!
Wish him/her..
Historical Events
Which were the important events of 30 May 1912 ?
- Saint Reinhilde
- Peru ? National Potato Day [1].
- United States ? Memorial Day (originally ? currently last Monday in May).
- Saint Ferdinand III
- Saint Gabinus
- Saint Jeanne d'Arc
- Trinidad and Tobago ? Indian Arrival Day(National Holiday).
Famous Birthdays:
- Julian Gustave: Symons writer.
- Alexander Langsdorf: physicist.
- Erich Bagge: German scientist, he developed with three others isotope separation apparatus.
- René Duvauchelle: French aviator, a World War II ace, awarded the title of 'Compagnon de la Libération' (English: Companion of the Liberation).
- Julius Axelrod: American biochemist, recipient of the Nobel Prize in Physiology or Medicine (Born 1912).
- Hugh Griffith: Wales, United Kingdom -- Actor (Ben Hur, Mutiny on the Bounty, Oliver!)
- Millicent Selsam: American author and academic (d. 1996)
- Joseph Stein: Dramatist / playwright (Fiddler on the Roof)
- US Marines sent to Nicaragua.
Featured Contents
Would you like to write an original contribution on a topic related to this specific date and get featured on Takemeback.to ? Send us your proposal!
Music Charts
Which were the top hits in that special week of May 1912 ?
Top #4 songs in the USA
- Love Never Dies - Harry Anthony & Inez Barbour
- Crucifix - Enrico Caruso
- Enrico Caruso - Aida - Celeste Aida
- Ring Ting A Ling - Ada Jones
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Introduction:Back in April, LG officially unveiled the LG G4- it's loved by many for it's unique and innovative design- equipped with 5.5-inch QHD dispay and buttons on the back. But how does it stack up to the new Huawei Nexus 6P. Just few days back at Google conference in San Francisco the device debuts, a first Nexus device from the Chinese company and it's a big boost for them as well.
What's similar on these two?There are few features that are rather similar on these two smartphones. Firstly, the displays of both the devices are close in size- 5.5-inches on the LG G4 and 5.7-inches on the Nexus 6P – and both are Quad-HD (QHD) with a resolution of 2560 x 1440 pixels. Both are powered by 64-bit Qualcomm Snapdragon processor, but different models.
Both came with 3GB of RAM and 32GB of internal storage- the LG G4 has a microSD card slot - there is no expandable memory option in Nexus 6P but it does comes in different storage options- 64GB and 128GB.
The LG G4 and Nexus 6P, both are equipped with an 8MP front-facing camera, and have both have the usual suspects- They both have the usual suspects – Wi-Fi, Bluetooth (4.1 on G4 and 4.2 on 6P), GPS, NFC, a microUSB2.0 port (Type-C on Nexus 6P) for charging and data transfer and quick charge battery.
Below is the technical specifications chart, take a deliberate look at it. Here you come to know how these two devices stack up against one another.
Technical Specifications:
And the winner is Huawei Nexus 6P.


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Bill & Ted's Bogus Journey Trailer (1991)
"Once... they made history. Now... they are history." 19 July 1991 Adventure, Fantasy, Comedy 98 mins
Amiable slackers Bill and Ted are once again roped into a fantastical adventure when De Nomolos, a villain from the future, sends evil robot duplicates of the two lads to terminate and replace them. The robot doubles actually succeed in killing Bill and Ted, but the two are determined to escape the afterlife, challenging the Grim Reaper to a series of games in order to return to the land of the living.
Watch the official Bill & Ted's Bogus Journey 1991 trailer in HD below or find more Bill & Ted's Bogus Journey videos on Vidimovie.


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We like small stuff here at HQ. I mean, large floral vases can be boring, let's be honest. When Chive began in 2005, we sought to shake up the world... View full product details
We have always loved the concept of a horizontal flower vase. It makes you think against the grain and the Hudson Arch vase does just that. This Arch vase was... View full product details
Atom is one of our more contemporary flower vases. A solid, heavy piece of hand blown glass, which we would challenge any mischievous pest of a pet to knock over... View full product details
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text: A very first for India! Let's see how it goes. Choose, compare and buy online. Get it delivered at door step. Get it fitted in select cities as of now Pay by Credit/Debit cards, Bank transfer or even Cash on Delivery More information in their website: ChangeMyTyre.com :: India's First Online Tyre Store