text:
The Katherine River is ready to flood as a strong monsoon basin makes thick rains and stormy showers over the Northern Territory, recording the most wet day in five years, and also there is around 20 per cent opportunity of a cyclone pointing in the northern region on Australia Day. The minimal pressure system situated close to Katherine is prospective to track westwards over the coming two days, with falls of up to 150mm expected on Tuesday, and Bureau of Meteorology reported that water spills over from the shoulder of Waterhouse River onto the road close Beswick region, in the same time Darwin Airport's rainfall measuring device registered 145.6mm for the 24 hours until 9:00am on Tuesday, which the Bureau of Meteorology reported was the most wet day since January 25, 2012. Serious weather warnings are by leaps and bounds for the Daly, Tiwi, Arnhem, Gregory and Carpentaria districts, and also there has been small flooding of the Waterhouse River close Beswick Bridge, with an average flood warning in the region, and on the Katherine River Gorge Road.
Katherine River is situated in the Northern Territory, Australia. Its source are in Nitmiluk National Park, it flows from one side to the other of the town of Katherine, and is a major branch of the Daly River. The first European to see and name the river was the Scottish explorer John McDouall Stuart on 4 July 1862, and named it Katherine after Catherine Chambers, the second daughter of expedition sponsor James Chambers.


text:
build your own vibrating feeder
build your own vibrating deck
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Make a hummingbird feeder in 6 min. & 43 sec.. Easy, clean, no glue. Recycled plastic bottle, enjoy the nature and birds. You need only a cutter !!. Hang-it ... ) ...Read More
Mining Vibrating Hopper Feeder Design,Crusher USA
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build your own vibrating wash plant Grinding Mill China click chat get price Plans To Build A Vibrating Screen,Manganese Crusher. Search plans to build a vibrating screen to find your need.Read More
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30" panel for goats & sheep,Build Your Own Feeders ...
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Family Fun ~ Build Your Own Feeder,WJHG
Family Fun ~ Build Your Own Feeder. Updated: Thu 3:15 PM, Dec 09, 2010. Home / Feature / Headlines List / Article ; Winter can be a very difficult time for wildlife. Most young animals dont survive their first season of cold winds and low food supplies.Read More
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subset: commoncrawl


text:
If I were coaching today, I would love the new NCAA rule which permits coaches to hold practices with their entire teams for a maximum of two hours a week in the offseason.
I am in favor of anything that improves the quality of play in college basketball. I believe there has been a downturn in quality now for some time -- not just in the fundamentals of the game at the college level, but in many aspects of team play as well.
Current NCAA preseason regulations allow student-athletes to have eight hours of team-related activity during the week. Previously, teams were allowed to use up to two of these hours to work with groups of no more than four players at a time until the start of official practice in October. The other six hours typically consist of weight training and physical conditioning.


text:
Businesshotel LUX
Select your stay dates to check availability
Businesshotel LUX
About the hotel
Property Location
With a stay at Businesshotel LUX in Emmenbruecke, you'll be close to Musegg Wall and Loewenplatz. This hotel is within close proximity of Lion Monument and Glacier Garden.
Make yourself at home in one of the 36 air-conditioned rooms featuring minibars and flat-screen televisions. Complimentary wireless Internet access keeps you connected, and cable programming is available for your entertainment. Bathrooms have showers and hair dryers. Conveniences include phones, as well as safes and desks.
Rec, Spa, Premium Amenities
Take in the views from a terrace and make use of amenities such as complimentary wireless Internet access.
Enjoy a satisfying meal at a restaurant serving guests of Businesshotel LUX.
Business, Other Amenities
Featured amenities include dry cleaning/laundry services, luggage storage, and laundry facilities. Free self parking is available onsite.
Hotel Facilities
- Laundry facilities
- Free breakfast
- Front desk (limited hours)
- Number of floors - 4
- Number of buildings/towers - 1
- Free WiFi
- Free self parking
- Luggage storage
- Dry cleaning/laundry service
- Terrace
- Restaurant
- Total number of rooms - 36
- Year Built 2013
Room Facilities
- In-room safe
- Iron/ironing board (on request)
- Flat-panel TV
- Desk
- Air conditioning
- Daily housekeeping
- Cribs/infant beds (surcharge)
- Hair dryer
- Cable TV service
- Phone
- Minibar
- Free WiFi
- Private bathroom
- Shower only
Hotel Policy
National Rating
Hotelstars Union assigns an official star rating for properties in Switzerland. This property is rated 4 stars.
Know Before You Go
- Guests can arrange to bring pets by contacting the property directly, using the contact information on the booking confirmation (surcharges apply and can be found in the Fees section).
The following fees and deposits are charged by the property at time of service, check-in, or check-out.
- Pet fee: CHF 20 per pet, per night
- Late check-out fee: CHF 50
- Crib (infant bed) fee: CHF 10.00 per stay
- Rollaway bed fee: CHF 50.00 per day
The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.Show all hotel policy Show less hotel policy


text:
Music20. Apr, 2010.
Punk on Punk - NYC in 1977 As Seen Through the Eyes of Punk Magazine
Thanks again to YouTube for allowing us access to footage that might have otherwise been forever lost. This Australian TV clip features John Holmstrom and Legs McNeil of Punk Magazine definitively proving that no one has ever made a dime in rock journalism. The clip, which briefly drops into silence, reportedly shows the NYC-based pair in their offices some time in 1977, with the best bit coming after a clip of English punks are shown. The lines of demarcation between the various punk movements have gone down in the annals of history. Here, then, a first hand look at just how seriously they were taken.


text:
Quick Details
- Place of Origin: Guangdong, China (Mainland)
- Brand Name: KFD
- Model Number: 45W universal adapter
- Usage: Laptop
- Output Type: AC
- Connection: Plug In
- Model: 2016 new smart
- Power:: 45W universal
- tips:: 13 tips for selection
- sample order:: available
Packaging & Delivery
|Packaging Details
|Plastic bag+brown box,60pcs in one carton.Can according to customers" requirements
|Delivery Time
|Shipped in 7 days after payment
Technical Specification:
Condition:100% Brand New
Input: 100 to 240V AC,1.0-0.6A, 50 to 60Hz
Protection: over-current, voltage and auto recovery
Output protection: over-load and short-circuit protection
AC inlet: plug-in type
Insulation Strength: Class A
Operating Temprature: -10°C~+40°C (10-90%R.H)
Storage Temprature: -40°C~+60°C (10-90%R.H)
Operating Humidity: 10% ~ 90% RH Non-condensing
Storage Humidity: 5% ~ 95% RH Non-condensing
Case materials: PC, ABS, or equivalent
Packing details:1 piece per plastic bag + inner box (negotiate when order)
Input: 100 to 240V AC,1.0-0.6A, 50 to 60Hz (worldwide use)
Output: 45W smart
DC pin size: Universal
Outlet: 3-prong/2-prong
Company information:
1):Over 13 years of professional experience in design and producing laptop adapters,6000Square Factory!
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|7: printer adapter
As a manufacturer and wholesaler here for more than 10 years,our products already got high reputation in the international market,we would assure you the High quality and Competitive price for long-term cooperation.


text:
Meryle Secrest's Frank Lloyd Wright: A Biography focuses on Wright's family history, personal adventures, and colorful friends and family. Secrest had unprecedented access to an archive of over one hundred thousand of Wright's letters, photographs, drawings, and books. She also interviewed surviving devotees, students, and relatives. The result is an explicit portrait of both the genius architect and the provocative con-man.
"Secrest seizes the themes most evocative of certain of our cultural myths, forging them into a coherent and emotionally plausible narrative."—New Republic
"An engaging narrative."—New York Times Book Review
"The real triumph of this biography . . . is the link it makes between Frank Lloyd Wright's personal life and his architecture."—The Economist
"Secrest's achievement is to etch Wright's character in sharp relief. . . . [She] presents Wright in his every guise."-Blair Kamin, Chicago Tribune
"An extremely engaging profile."—The Philadelphia Inquirer
"A spellbinding portrait."—Library Journal
"The best [biography] so far, a huge and definitive accumulation of fact."—Time
In this superb, subtle, demythologizing biography of Wright (1869-1959), we meet a shrewd yet gullible architect who fostered a view of himself as a misunderstood, embattled genius, a narcissist who unconsciously courted catastrophe while blaming the vengeful hand of fate as he overcame accidents, bankruptcy, lawsuits and hounding by his morphine-addicted second wife. Drawing on a trove of letters, Secrest ( Salvador Dali ) traces Wright's ``secret conviction of worthlessness'' to the contradictory influences of his freethinking, erratic Welsh mother and his jealous, spendthrift father, a New England minister. She discusses the dynamics of the architect's three marriages, recounts his clashes with Louis Sullivan and Lewis Mumford, and digs beneath his ``quasi-mystical Celtic beliefs'' to pinpoint the multiple influences on his fervent quest for an organic architecture. A definitive portrait of a mercurial titan. Photos. BOMC and QPB alternates. (Sept.)


text:
Results 1 to 5 of 5
04-02-08, 14:18 #1Registered User
- Join Date
- Apr 2008
- Posts
- 2
Unanswered: Trouble connecting to MS Access mdb files
I have been looking for information on how to read mdb files from Perl. I can't see what I am doing wrong, but I am not able to connect to any mdb file. My environment is ActivePerl on Vista Business.
Here is my code:
use strict;
use Data::Dumper;
use DBI;
#open connection to Access database
my $dbh = DBI->connect('dbi:ODBC:driver=microsoft access driver (*.mdb);dbq=c:\Users\paul.hodor\Documents\testdb.m db')
or die "Can't connect to Oracle database: $DBI::errstr\n";;
print Dumper $dbh;
#prepare and execute SQL statement
my $sqlstatement="SELECT * FROM nametable";
my $sth = $dbh->prepare($sqlstatement) or die "Can't prepare SQL statement: $DBI::errstr\n";
my $sth->execute or die "Can't execute SQL statement: $DBI::errstr\n";
And the output:
$VAR1 = bless( {}, 'DBI::db' );
Can't call method "execute" on an undefined value at mdb_extract.pl line 14.
The file specification appears to be correct. If I change the file name to something non-existent, I get the following error:
DBI connect('driver=microsoft access driver (*.mdb);dbq=c:\Users\paul.hodor\Documents\testdb1. mdb','
',...) failed: [Microsoft][ODBC Microsoft Access Driver] Could not find file '(unknown)'. (SQL-HY000
) at mdb_extract.pl line 6
Can't connect to Oracle database: [Microsoft][ODBC Microsoft Access Driver] Could not find file '(un
known)'. (SQL-HY000)
I am also able to convert the file to csv using the DataConversionTool.com MDB Exporter. I am puzzled that it does not work from Perl. Any help will be appreciated.
04-03-08, 06:40 #2Registered User
- Join Date
- Feb 2008
- Posts
- 8
So u are wrong at $sth->execute!!!!!!!!!!!!!!
Use the follwoing(see the "()" after execute)
it is not able to identify ur execute.
04-03-08, 22:01 #3Registered User
- Join Date
- Apr 2008
- Posts
- 2
still not
I wish it had been that simple... Tried it, but the parentheses did not change anything
04-13-08, 00:47 #4Registered User
- Join Date
- Oct 2002
- Location
- Baghdad, Iraq
- Posts
- 697
Can you use ADO instead of ODBC? (You'll need the DBD::ADO driver from package manager) The JET engine works most closely with DAO, but ADO is a close second, and you can actually get drivers for ADO. This requires that msjetoledb40.dll be in your system folder. (Has that changed to something other than windows/system32 on Vista? I've never upgraded from XP...)
My code to connect to an mdb file and dump all table info is:
use DBI; use strict; my($user, $pass) = (); my $dbh = DBI->connect("dbi:ADO:Provider=Microsoft.Jet.OLEDB.4.0;Data Source=c:/foo/bar/database.mdb", $user, $pass, { RaiseError=>1, PrintError=>1 }); $dbh->table_info->dump_results(60); # Use 60 character lines instead of 35 $dbh->disconnect();
So u are wrong at $sth->execute!!!!!!!!!!!!!!
04-22-08, 13:56 #5Registered User
- Join Date
- Sep 2006
- Posts
- 1
Your post is a little confusing. You're using the MS Access driver to query an Oracle DB? If you're trying to connect to an Access db, then you might want to check that you have DBD::ODBC installed. Here's what I had to do to get perl to connect to an Access db:
installed DBI perl module (looks like you've done that)
installed DBD::ODBC - I had to set the ODBCHOME environment variable to point to the location of the Access driver before the install would work.
setup an odbc connection: start->admin tools->odbc->User DSN->Add…->Microsoft Access Driver (*.mdb) (pick the ds name and select the database you want to connect up) then go to Select-> and select the path to the database. e.g. x:\dbs\testdb\tdb.mdb NOTE: if you are allowing access via other users, use System DSN.


text:
Denim Heat Deodorant Roll-on - For Men (50 ml)
The intensity that colors his aquiline features is one of a kind; not many people are as passionate about the things they believe in. For the man who puts his heart and soul into what he does, Denim presents Heat Deo Roll-on, a mass premium that arrests moisture and keeps him fresh all day long. The deeply enlivening aroma of the deodorant roll-on keeps you on your toes even as the tepid heat simmers around you when the hot and stuffy days are unrelentless. Keep cool, calm and confident with Denim Heat Deo Roll-on.
nice roll on
akash agnihotri
Certified Buyer
17 May, 2012
The product is very good.
Sreethesh Pai
Certified Buyer
20 May, 2014


text:
Astray is an experiential travel company that offers unique trips that span all over the world. Their team of explorers seek to inspire you to step off the beaten path, to embrace the unexpected and immerse yourself in the extraordinary. Their trips embrace authentic accommodation and local transportation to bring you face-to-face with the world's most fascinating cultures, customs and awe-inspiring wildlife.
The website is a responsive design that has a parallax scrolling effect and an app-like design. The website was designed to be interactive and more of an experience for the user - just as travel is an experience for the traveler. Keeping the user experience in mind, the design is clean, minimal and easily navigated.


text:
Employers Need to Optimize Enrollment Support
April 20th, 2017
Effective communication and optimal enrollment processes are critical for employees to fully understand their benefits options. This is especially important for millennials as younger employees feel the least confident in their benefits decisions. While millennials are the most tech-savvy generation, the majority of them value one-on-one consultations with a benefits expert.
Employers are starting to diversify their decision-support approach with millennials and not just rely on online support tools to provide the individualized support they seek. One-on-one
consultations, in-person meetings, and workshops are just some of the ways for employers reach younger workers.
Employers have a unique role in helping employees from all generations navigate their choices. This will help businesses maintain strong loyalty among employees and continue to attract
top talent in 2017 and beyond.
To learn more about optimizing enrollment support and other benefits trends, fill out the short form below to get immediate access to our Benefits Trends whitepaper.
Categories: Benefit Management, Open Enrollment


text:
April 14, 2008
There is an immense volume of literature that expresses an abiding concern with the evident and persistent disparities in access to health care. The usual approach to solving for these disparities is some new form of government intervention, usually by various kinds of forced access or subsidies regime. Unfortunately, the chief consequence of these proposals will be, as it has usually been, to make a health system balkier and less responsive than it is was before, says Richard Epstein, a senior fellow with the Hoover Institution.
For example:
- State-based medical licensing systems impose sharp restriction on the free flow of labor across state lines.
- The Health Insurance Portability and Accountability Act (HIPAA) imposes numerous restrictions on the use and transfer of information which drives up the cost of medical care in the name of the protection of patient privacy.
- A costly and unreliable medical malpractice system leads to the closure of desperately needed facilities that serve marginal communities.
- Medicare offers huge subsidies for affluent seniors on the backs of people with a fraction of those affluent seniors' income.
- Most importantly, perhaps, constant barriers are thrown in the path of nonmedical firms entering the market to supply health care.
Open competition will do more to lower costs and increase access than will the next generation of health care gimmicks that have such enormous, if unjustified, appeal, especially in an election year, says Epstein.
Source: Richard Epstein, "Health Care Disparities: Deregulation First, Redistribution Last," Health Affairs, March 13, 2008.
For text:
Browse more articles on Health Issues


text:
Phone: (289) 320-8250
1238 Dominion Road
Fort Erie, Ontario, L2A 1H7
Brushed Chrome Finish Metal Hinge - 3'' x 3 3/16''The Onward Hardware brushed chrome finish metal hinge with squared and round corners is mostly used on wooden internal and external doors but also on casement windows, various cupboards and other pieces on furniture. The round corners have a 5/8'' radius. Its removable pin provides easier installation or removal of the door. The safe working load is 50 pounds per hinge. Its height is 3 3/16'' and its width is 3''. It comes in a package of 4 units and the screws are included.


text:
Terms | Privacy | Copyright | FAQ
©2005-2017 TheTopTens® All rights reserved.
Top 10 Malayalam Actors of 21st Centuryraju90
The Contenders: Page 2
21 Anoop Menon
Actor who is multi talented, one who has a unique style of actingV 1 Comment
22 Nedmudi Venu
Should be one among best 5
23 Manikuttan
24 Murali Gopy
25 Suraj Venjaramoodu
Won national award for best actor
26 Salim Kumar
Best comedian in malayalam. National award holder
Best comedian. Natural actingV 1 Comment
27 Hemanth Menon
28 Aju Varghese
Yess... Aju is awesome... Best comedy in malayalam at present.. I love aju and nivin pauly pair... They both combine together the film will have a fantastic comedy... you can see that in thattathin marayathu, even recent film oru vadakkan selfie... Good. Keep gngV 2 Comments
29 Sreenath Bhasi
30 Jacob Gregory V 2 Comments
31 Baburaj
32 Manu
33 Sreenivasan
He is one of the Amazing Actor as well as comedian in Malayalam cinema industry, Everybody knows his talent and like him, if anybody not like him because they may having black complex...
34 Nedumudi Venu
He is very talented and must be in the top 5
35 Biju Menon
Should be in the best 10
36 Chala Meri
She is a great actress
37 Dhyan Sreenivasan
38 Rahman
39 Thilakan
BAdd New Item
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Related ListsTop 10 Malayalam Actresses of 21st Century Top 10 Male Actors of the 21st Century Top Ten Actors In Asia of the 21st Century Best Saturday Night Live Actors of the 21st Century Best Movies of the 21st Century With Tons of Famous Actors
List Stats
1,000 votes
40 listings
5 years, 11 days old
40 listings
5 years, 11 days old
Top Remixes
1. Mohanlal
2. Mammootty
3. Prithviraj Sukumaran
2. Mammootty
3. Prithviraj Sukumaran
1. Mammootty
2. Mohanlal
3. Suresh Gopi
2. Mohanlal
3. Suresh Gopi
Error Reporting
See a factual error in these listings? Report it here.


text:
Report – Design of Jaguar's 3 Series rival "finalized"; Concept preview at Paris Motor Show
Anjan Ravi, I'm a true-blooded petrolhead. Hope you enjoy our news stories, launch coverages, motorshow coverages and test drive reports.
Ian Callum, Jaguar design director, is quoted telling Autocar UK that he "finished design work" of the company's upcoming BMW 3 Series rivaling sedan. Callum says that the design of the sedan would follow the current design trends of Jaguar.
Codenamed X760, the sub-XF sedan will be based on Jaguar's new iQ aluminium architecture. Jaguar officials told the media that the rear-wheel drive sedan would offer superior performance and driving dynamics, and would be powered by a new family of four-cylinder petrol and diesel engines. Production of these engines is expected at Jaguar's new engine facility in Wolverhampton, UK, while the car would be built at Jaguar Land Rover's Solihull plant.
Autocar expects the baby saloon to feature a trapezoidal grille inspired by the F-Type, a clamshell bonnet with a couple of power bulges, and a sporty-looking profile.
Jaguar could show a pre-production concept at the Paris Motor Show next year, followed by the production model at the 2015 Geneva Motor Show. Sales of the sedan would start by mid-2015.
Further, Callum said that the iQ platform was very flexible and that the company would make full use of it. Among other models based on the iQ platform would be a crossover (previewed through the C-X17 concept), an estate and a coupe based on the new sedan.


text:
Stover, Kaite Mediatore, "Stalking the Wild Appeal Factor: Reader's Advisory and Social Networking Sites." Reference & User Services Quarterly 48.3 (2009): 243-246, 269.
Read online.
This is a brief article that mentions three social networking sites focused on books and reading. The sites in question are Shelfari, Library Thing, and GoodReads. The article is a call for readers' advisors to embrace these technologies, and it offers some commentary on the sites.
Some brief notes:
- Food for thought: "Readers' advisory (RA) is one of the most social services libraries offer" (244). It certainly is a reason I was drawn to librarianship, and it is an interest and professional area that I try to keep up with even as I do very little of it as an academic librarian. Personally, I think it is an important skill for us to have, and I think we should be promoting recreational reading a bit more on our campuses. I have had a thing or two to say on the matter if anyone is interested.
- The author argues that expanding RA online will create larger communities and that the library's space should include the virtual space as well. That sounds good to me.
- A big benefit of using these online services for library staff: "Not only are library staff reaching new and different patrons, but they are improving their own knowledge of books read, heard of, and glanced at, and it is all in one place. Library staff are equipped with easy-to-use tools that help them organize their own reading and evaluate their strengths and weaknesses in reading areas" (244). Personally, that is a benefit of using these kinds of tools: I can keep track of what I read and get a sense of what I read and tend to favor. Looking at it over time, combined with my annual book list exercise, gives a sense also of where my reading preferences change. Maybe more of us should be doing these things and taking the time to reflect on what we read.
- The author goes over briefly over descriptions and features of the three services I mentioned above. In terms of preferences, it seems those who prefer GR do so due to the fact you can add an unlimited number of books to your lists: Library Thing was praised for its tagging features (245).
- Conclusion: "Try out all of the Web toys out there. It's the responsibility of a good readers' advisor to at least be familiar with the numerous Internet playthings. But once they've all been taken for a test run, commit to one and politely show the others the door. It will be enough of a time commitment to keep one account current on a reading network, and it will be very important to keep that account up to date" (246). This is consistent with my personal philosophy of keeping up and "try it out, use it if it works, discard it if it does not."
Disclosure note: I am a GoodReads user, which in my case, includes "librarian" privileges (I can edit records among other things). You can find a link to my profile there in the right side bar of the blog. If anything, consistent with the article, a reason I liked it better was that I could add all the books I wanted. However, Library Thing does seem to be the librarians' favored service overall (conclusion based on informal observation).


text:
Yesterday was a beautiful, sun-filled day.
I put Marty's chicken and dressing recipe in the crock pot in the morning, and had my main meal at suppertime.
My younger daughter asked Wednesday if I'd like her to bring me leftovers Thanksgiving afternoon. But I told her no, I had my meal all ready to go. But it was mighty sweet of her to offer.
Charlie is sleeping on the ottoman with his tongue hanging out the right side of his mouth, blissful in his ignorance of this oddity.
I guess he doesn't worry about not having more than two teeth. He still manages to eat. Although I do have to hold Abi back, a greedy creature with a full set of teeth who always bullies him at meal time.
I thought I might do a bit of Christmas decorating. But I'm still just not ready for some reason. Usually around Thanksgiving, my decorating impulses kick in and I drag out my big plastic Christmas box. But that didn't happen.
Did any of you start decorating yet?
As many of you have already mentioned, I find that the older I get, the less stuff I want to drag out.
The less stuff I want around my home on an everyday basis.
I suppose you begin to desire a more stream-lined and simplified life at some juncture. I'm there.
I don't desire a bigger place to live than my 725 square foot apartment. I spend most of my time here and I never feel "claustrophobic." And it's the smallest home I've ever lived in.
I have what I need. I have my patio with the gazebo and container gardens.
I have my living space that is elongated into my dining space. A small kitchen. A fairly big bedroom with two walk-in closets. And a small bathroom like most apartments seem to have.
The place was built in sixties. And could certainly use some updating.
I cleaned out the bird bath yesterday.
I love to watch how the birds dip down, get a bit of water, then lean back and swallow. Almost like watching a seesaw.
I wonder if kids nowadays know what a seesaw is? Do they still have those things?
Oh, I still remember the school merry-go-round. How you jumped on and off while it was going round and round, and sometimes you fell and skinned a knee.
How you'd feel a bit dizzy as it went faster and faster. Feeling a tad nauseated and exhilarated at the same time.
Back to birds...
I find birds fascinating. My fifth grade teacher, Mrs. Lipsky, who took us on early Saturday morning bird walks and cultivated my interest in birds, would be proud. But I'm sure she's long dead.
She gave me a gift however, when my love of all things nature blossomed.
Around 6 a.m. on those Saturday mornings, a small group of us trudged through the woods, sticks and leaves crackling beneath our feet.
Which brings me to this notion: Even when you don't have any money, you can go right outside and be the benefactor of so much.
The expanse of sky, in almost endless shades of blue on any given day. The stars against the inky black canvas of night.
The birds and squirrels with all their antics. Bird song. So many varieties of chirping!
A breeze briefly caressing my face.
Rain. Oh, how I love the rain!
To me it is a daily gift. Without these sights and sounds I've grown so accustomed to loving, I think I would be lost.
I hear sirens in the distance. A part of living in the middle of the city.
I always wonder where they're going. If a house has burned down and left a family homeless. If a child has drowned or been hurt.
I imagine the utter despair of having your home go up in flames, gone in an instant.
I imagine a parent who could not have begun to imagine, when they awoke that morning, that by dusk, they would have lost a child.
I think that must be the most cruel of life's many chapters. The page on which your beloved child precedes you into death.
And then I think of the parents I interviewed, years ago, who are still waiting for their child to come home. A child that would now be old enough to be a parent or grandparent.
How do they do it? Those parents? Put one foot in front of the other and wonder if they will go to their grave never knowing what happened to their child.
I wonder if they can forget, for a minute or two, the tragedy that has trapped them in a cycle of never knowing?
Or if any bit of brief happiness is automatically eclipsed by the not knowing?
Sorry to be so morose. I guess that's just where my thoughts go when I hear those sirens.
Until the sound begins to fade in the distance. Taking my woeful ruminations right along with it.


text:
Early Scan Bucks - recommendations?(6 Posts)
MrsJohnDeere Sun 02-Dec-12 19:52:59
BoyMeetsWorld Sun 02-Dec-12 19:41:32
MrsJohnDeere Sun 02-Dec-12 17:58:18
BoyMeetsWorld Sun 02-Dec-12 08:23:11
SlightlySuperiorPeasant Sat 01-Dec-12 22:14:28
BoyMeetsWorld Sat 01-Dec-12 22:04:45
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Donations directly fund work to find a cure for Dupuytren's and related conditions.
Our heartfelt thanks go out to those who continue to make this effort possible through generous contributions during the year 2011:
Contributions up to $250:
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Joanne Fay
Fidelity Charitable Gift Fund
Jeffry L Forbes
The GE Foundation
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Gerald Klafter
C Stephen Lewis
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Contributions of $250 up to $1000
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Contributions of $1000 up to $5000
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Please make a contribution right now or contact us to learn how you can support the effort to find a cure.
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The Dupuytren Foundation is a 501(c)3 Public Charity, ID 26-3886958 for tax deductible donations.


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Administration of chemically synthesized ghrelin (Ghr) peptide has been shown to increase food intake and body adiposity in most species. However, the biological role of endogenous Ghr in the molecular control of energy metabolism is far less understood. Mice deficient for either Ghr or its receptor (the growth hormone secretagogue receptor, GHS-R1a) seem to exhibit enhanced protection against high-fat diet-induced obesity but do not show a substantial metabolic phenotype on a standard diet. Here we present the first mouse mutant lacking both Ghr and the Ghr receptor. We demonstrate that simultaneous genetic disruption of both genes of the Ghr system leads to an enhanced energy metabolism phenotype. Ghr/Ghr receptor double knockout (dKO) mice exhibit decreased body weight, increased energy expenditure, and increased motor activity on a standard diet without exposure to a high caloric environment. Mice on the same genetic background lacking either the Ghr or the Ghr receptor gene did not exhibit such a phenotype on standard chow, thereby confirming earlier reports. No differences in food intake, meal pattern, or lean mass were observed between dKO, Ghr-deficient, Ghr receptor-deficient, and wild-type (WT) control mice. Only dKO showed a slight decrease in body length. In summary, simultaneous deletion of Ghr and its receptor enhances the metabolic phenotype of single gene-deficient mice compared with WT mice, possibly suggesting the existence of additional, as of yet unknown, molecular components of the endogenous Ghr system.
- growth hormone secretagogue receptor, constitutive receptor activity
- locomotion
after its discovery in 1999, a series of pharmacological and clinical studies suggested that the gastrointestinal hormone ghrelin (Ghr) was an endogenous regulator of energy balance. Administration of Ghr was shown to promote feeding (23), increase adiposity in rodents (14), and to increase food intake in humans (6). In obese individuals, Ghr levels were demonstrated to be lower than in healthy lean control subjects (16, 25). Careful monitoring of Ghr levels revealed that levels are highest before a meal (3) and subsequently drop postprandially (24). Ghr has therefore been proposed to be a meal initiation factor that induces hunger and subsequent food ingestion (3). New studies on the central action of Ghr on peripheral cell metabolism in rats (17, 22) suggest that Ghr might also be a meal preparation factor. As an integral component of a gut-brain axis that controls nutrient partitioning, it could act to prepare metabolic pathways to more efficiently store ingested calories.
Initial descriptions of Ghr-deficient mice resulting from targeted gene disruption, however, reported normal energy balance, food intake, and adiposity on a standard diet (19, 29, 30, 33). One interpretation of these early findings was that endogenous Ghr may not be of crucial relevance for physiological energy homeostasis. Others attributed such lack of a metabolic phenotype to compensatory processes during early developmental phases or the presumably redundant multiplicity of pathways controlling energy balance. Furthermore, a series of important studies by Birgitte Holst and Thue Schwartz (10, 12) provided solid evidence, suggesting that the (only known) Ghr receptor [growth hormone secretagogue receptor (GHS-R1a)], a 7-transmembrane receptor and member of the G protein-coupled receptor family 1, exhibits basal constitutive activity. GHS-R1a is expressed in numerous tissues that are known to control energy homeostasis and food intake, such as the arcuate and ventromedial nucleus of the hypothalamus (8). GHSR is also expressed in dopaminergic neurons, e.g., within the substantia nigra and ventral tegmental area (8, 32), in brain stem areas such as the nucleus of the solitary tract (32), but also in peripheral tissues such as brown adipose tissue (2) or pancreas (7, 28). The constitutive activity of the Ghr receptor therefore could still provide a possibly residual signaling in Ghr target cells, even in the absence of the primary ligand in mice with targeted disruption of the Ghr gene (11).
Finally, the putative existence of an additional receptor (or ligand) of the Ghr system might explain the lack of a major energy balance phenotype in existing Ghr- or Ghr receptor-deficient animals and can neither be proven nor discarded on the basis of the presently available data (9, 27). We tested the hypothesis that simultaneous deletion of Ghr and the Ghr receptor in mice would lead to a more significant energy metabolism phenotype than deletion of either the ligand or the receptor alone.
Generation of Ghr- and GHSR-deficient mice has been described previously (1, 26, 29). Ghr knockout (KO) mice of both sexes were intercrossed with GHSR KO mice (F0 generation) to generate a double-heterozygous F1 generation. Double-heterozygous F1 mice were inbred to produce double KO mice deficient for both Ghr and GHSR (dKO), or single KO mice deficient for Ghr or GHSR, respectively. F2 mice with both functional alleles for Ghr and GHSR were used as controls (WT). All results from animals with an age of 12–15 mo were derived from F2 littermates after inbreeding of the double heterozygous F1 generation. Confirmatory data on body weights and body lengths were derived from an additional population of F3 animals at the date of weaning (3 wk) and after 13 wk on chow diet. These mice were produced by homozygous inbreeding of F2 WT, Ghr KO, GHSR KO, or dKO mice. To establish genotypes, DNA was extracted from tail snips, and PCRs were performed using the primers and conditions depicted in Table 1. In addition, all genotypes were confirmed by performing radioimmunoassays to measure Ghr in plasma or by measuring pituitary GHSR gene expression, respectively.
All animals were single housed on a 12:12-h light-dark cycle at 22°C and fed regular chow diet with free access to food and water. All studies were approved by and performed according to the guidelines of the Institutional Animal Care and Use Committee of the University of Cincinnati.
Real-time PCR for pituitary GHSR mRNA expression.
After finishing all in vivo studies, mice were decapitated and pituitaries collected and immediately frozen on dry ice. RNA was extracted using the RNEasy Mini Kit (Qiagen), according to the manufacturer's instructions. After subsequent DNase treatment, reverse transcriptions were performed using SuperScript III (Invitrogen) and oligo(dT20) primers (Invitrogen). Real-time PCRs to validate for GHSR expression and for the ribosomal housekeeping gene L-32 were performed on a Bio-Rad iCycler by using iQ SybrGreen Supermix (Bio-Rad) and two different GHSR primer pairs, 1) GHSR forward primer 5′-TCCGATCTGCTCATCTTCCT-3′ and reverse primer 5′-GGAAGCAGATGGCGAAGTAG-3′, 2) GHSR forward primer 5′-CTACTTCGCCATCTGCTTCC-3′ and reverse primer 5′-AAGACGCTCGACACCCATAC-3′, and L-32 forward primer 5′-GCCAGGAGACGACAAAAAT-3′ and L-32 reverse primer 5′-AATCCTCTTGCCCTGATCC-3′.
Anthropometry analysis and body temperature measurements.
Whole body composition (fat and lean mass) was measured using NMR technology (EchoMRI, Houston, TX). Body length was defined as the distance between nose and rectum and was measured by using a digital high-precision sliding caliper. Body core temperature was measured in the beginning of the light phase in nonanesthetized mice by using a rectal thermometer (Physitemp, Clifton, NJ). Simultaneously, peritoneal body surface temperature was measured by using an infrared thermometer (Fluke, Grossostheim, Germany).
Energy balance physiology measurements.
Energy intake and expenditure, as well as home-cage activity, were studied by using a combined indirect calorimetry system (TSE Systems, Bad Homburg, Germany). After adaptation for >12 h, O2 consumption and CO2 production were measured every 45 min for a total of 76 h to determine the respiratory quotient and energy expenditure. Simultaneously, food and water intake and meal patterns were determined continuously for 76 h by integration of scales into the sealed cage environment. Meals were defined as food intake events with a minimum duration of 60 s, and a break of 300 s between food intake events. In parallel, home-cage locomotor activity was determined using a multidimensional infrared light beam system with beams installed on cage bottom and cage top levels and activity being expressed as beam breaks. Stationary motor activity (fidgeting) was defined as consecutive breaks of one single light beam at cage bottom level, ambulatory movement as breaks of any two different light beams at cage bottom level, and rearing as simultaneous breaks of light beams on both cage bottom and top level.
Blood parameters.
Blood was collected after an overnight fast from tail veins using EDTA-coated Microvette tubes (Sarstedt, Nuremberg, Germany) and immediately chilled on ice. After 15 min of centrifugation at 3,000 g and 4°C, plasma was stored at −80°C. For quantification of plasma Ghr levels, a commercially available radioimmunoassay [Ghrelin (Rat/Mouse) RIA; Phoenixpeptide, Burlingame, CA] was used. This assay is validated for the measurement of both des-octanoylated and octanoylated Ghr in nonacidified and acidified plasma samples and does not require protein extraction. For quantification of plasma insulin levels, a radioimmunoassay from Linco (Sensitive Rat Insulin RIA; Linco Research, St. Charles, MO) was used. Plasma leptin levels were measured by using an ELISA kit (Murine Leptin; Diagnostic Systems Laboratories, Webster, TX). Plasma glucose and nonesterified fatty acid (NEFA) were measured by using commercially available enzymatic assay kits from Wako (Autokit Glucose and NEFA C; Wako, Neuss, Germany). Plasma cholesterol levels were determined with the cholesterol oxidase method by using Infinity Cholesterol reagent, and plasma triglycerides were quantified by using the Infinity Triglyceride reagent (Thermo Electron, Pittsburgh, PA). All assays were performed according to the assay manufacturer's instructions.
Glucose tolerance test and insulin tolerance test.
For the measurements of glucose tolerance and insulin sensitivity, mice were subjected to 6 h of fasting and injected intraperitoneally with 2 g glucose/kg body wt (50% D-glucose (Sigma) in 0.9% saline) for the glucose tolerance test (GTT), and 1 U insulin/kg body wt (0.1 U/ml; Humolog Pen, Lily, Indianapolis, IN) for the insulin tolerance test (ITT). Tail blood glucose levels (mg/dl) were measured by using a handheld glucometer (TheraSense Freestyle) before (0 min) and at 15, 30, 60, 90, and 120 min after injection.
Fasting/refeeding experiments.
After 20 h of fasting, mice were refed with standard diet and food intake, and meal patterns were measured continuously for 24 h by using an automated food-monitoring system (TSE Systems, Bad Homburg, Germany).
Statistical analysis.
Unless indicated otherwise, all statistical analyses were performed on the basis of planned comparisons and/or using Fishers least significant difference (LSD) test. These analyses of statistical validity were selected because in each case simple comparisons were made with strong a-priori predictions on the basis of the genetic deletion of both Ghr and the Ghr receptor. Differences in the refeeding between groups, as well as in glucose levels during GTT or ITT were examined by two-way ANOVAs, and Fishers LSD post hoc tests. All statistical analyses were performed with Statistica 6.0 (StatSoft, Tulsa, OK). Experiment-wise α error was set at P < 0.05. All results are presented as means ± SE.
Generation of dKO mice.
To produce mice deficient for both Ghr and GHSR, homozygous KO mice for either Ghr or GHSR were intercrossed. The generation of Ghr-deficient mice has been described previously (1, 29). In a similar fashion as Ghr-deficient mice, GHSR-deficient mice were generated by using the high-throughput VelociGene gene-targeting system (26). The resulting double-heterozygous F1 generation was inbred to produce F2 animals. All animals with an age of 12–15 mo during the times of studies were littermates of this F2 generation. In addition, F2 animals of each genotype were bred true to generate F3 WT, Ghr KO, GHSR KO, and dKO mice to study the effect of Ghr deficiency, GHSR deficiency, or both in young animals (See supplemental information available online at the American Journal of Physiology Gastrointestinal and Liver Physiology website.). Genotypes were initially established by using PCR (Fig. 1A) from genomic DNA. In addition, Ghr and GHSR deficiency was verified in F2 mice by measuring total plasma Ghr levels and pituitary GHSR gene expression, respectively. Ghr KO and dKO mice showed no detectable levels of total Ghr, whereas GHSR KO and WT showed similar levels corresponding with normal mouse Ghr levels reported previously (Fig. 1B) (18, 23). GHSR KO and dKO mice did not express GHSR mRNA in their pituitaries, in contrast to dWT and Ghr KO mice (Fig. 1C). Fertility was normal in all mice, and no differences in mortality rate or overall health could be observed between groups.
Reduced body weight of dKO mice.
Body weight was found to be significantly decreased in both old dKO mice (13.4 mo) (P = 0.032, Fig. 2A), as well as in mice of young age (13 wk) (P = 0.036, Supplemental Fig. S1). Body weight at the age of weaning (3 wk after birth) was comparable between groups (Supplemental Fig. S1). The decrease in body weight of old mice was predominantly due to a decrease in fat mass (P = 0.047, Fig. 2C) but not lean mass (P = 0.18, Fig. 2D). Young mice at 13 wk of age also showed a slightly but significantly reduced lean mass (P = 0.011, Supplemental Fig. S1). However, the percentage of both fat and lean mass in young mice was comparable between groups (Supplemental Fig. S1). Old dKO mice showed reduced body length (P = 0.013, Fig. 2B), whereas young dKO mice at 13 wk did not differ from WT controls (P = 0.78, Supplemental Fig. S1). Leptin levels in old mice and IGF-I plasma levels in young and old mice did not differ between genotypes and did not accompany the observed changes in fat mass or body length, respectively (Table 2).
Altered lipid profiles in dKO mice.
Free fatty acid and triglyceride levels did not show differences between groups, but cholesterol levels were significantly lower only in old dKO mice compared with WT mice following an overnight fast (P = 0.015, Table 2).
Normal feeding behavior in dKO mice.
No differences in overall food intake (Fig. 3A, left) or water intake (data not shown) were found between aged mice with deficiencies for Ghr, GHSR, or both genes compared with WT controls. Twenty-four-hour food intake did not differ between genotypes during the light or dark phase, respectively (Fig. 3A, right, top). In addition, normalization of 24-h food intake per body weight (Fig. 3A, right, middle) or lean mass (Fig. 3A, right, bottom) did not reveal any differences in relative food intake between genotypes. Meal patterns were also not affected by deficiencies for Ghr, GHSR, or both genes. The number of meals per 24 h (Fig. 3B, left, top), the average duration of the meals (Fig. 3B, right, top), the average size of a meal (Fig. 3B, left, bottom), and the average meal rate (Fig. 3B, right, bottom) did not differ between the four genotypes.
Increased energy expenditure and body core temperature in dKO mice.
Only dKO mice, but not mice deficient for either Ghr or the Ghr receptor, showed significantly higher energy expenditure (Fig. 4A, left) in both the light (P = 0.0006) and dark phase (P = 0.0007; Fig. 4A, right, top). Normalization of the average energy expenditure to the "metabolically active" lean tissue corroborated this finding (light phase P = 0.0027, dark phase P = 0.006 vs. WT, respectively; Fig. 4A, right, bottom). This increase in energy expenditure was consistent with higher body core temperature of dKO mice (P = 0.043; Fig. 4C, top, +0.5°C), whereas peritoneal surface temperature (Fig. 4C, bottom) was not found to be significantly higher (P = 0.73). As depicted in Fig. 4B, we were unable to find any changes in the respiratory quotient between groups.
Increased spontaneous physical activity in dKO mice.
In parallel to the indirect calorimetry measurements described above, locomotor activity was monitored by using infrared beam break systems (Fig. 5A). Total locomotor activity (Fig. 5A) was further dissected into ambulatory movements (Fig. 5B), stationary movements (Fig. 5C), and vertical movements (rearing, Fig. 5D). dKO mice showed significantly more stationary movements (P = 0.033 dark phase; P = 0.036 light phase; Fig. 5C) and exhibited strong tendencies toward higher ambulatory and rearing activity. Interestingly, GHSR KO mice showed no significant differences in locomotor activity, and Ghr KO mice only showed a minor increase in total locomotor activity during the light phase, compared with WT control mice (P = 0.004; Fig. 5, A, B, and D, right).
Normal insulin sensitivity in dKO mice.
After an overnight fast, plasma glucose (P = 0.86, Fig. 6A) and plasma insulin levels (P = 0.12, Fig. 6B) did not differ between aged WT and dKO mice. A GTT (intraperitoneal glucose bolus: 2 g glucose/kg body wt) overall failed to reveal significant differences in glucose tolerance between genotypes (Fig. 6, C and D). Mice deficient in either Ghr, GHSR, or both showed lower glucose peak levels at a single time point (15 min after the injection), possibly suggesting a slightly faster release of insulin (Fig. 6C). To further investigate the endogenous role of the Ghr system in the control of glucose metabolism, mice were subjected to an ITT (1 U insulin/kg body wt) (Fig. 6, E and F). In Ghr KO mice, glucose levels were similar to WT mice. In dKO and GHSR KO mice, glucose levels, however, dropped more rapidly. After 15 min, glucose values in dKO mice were 25 mg/dl (P = 0.08), or 11% lower than in WT mice. In GHSR KO mice, glucose levels after 15 min were 30 mg/dl (P = 0.0061), or 15.7% lower than glucose levels of WT mice after 15 min. In general, glucose levels of dKO and GHSR mice tended to remain lower throughout the 120 min of the ITT, compared with WT mice (Fig. 6E). However, although integrated (area under the curve) glucose levels in both GHSR KO and dKO mice tended to be lower compared with WT control mice (dKO: P = 0.105, and GHSR KO: P = 0.065; Fig. 6F), the deficiency of Ghr, its receptor, or both did not seem to have a major impact on overall insulin sensitivity or the overall regulation of glucose homeostasis.
Normal meal pattern following food deprivation in dKO mice.
Old mice of all four genotypes were fasted for 20 h and then given free access to standard chow diet. Subsequently, food intake and meal patterns were analyzed for 24 h using an automated food intake monitoring system. No changes were observed in overall food consumption between genotypes (including normalization of food intake per body weight or lean mass). Although a meal pattern analysis of the first 4 h of refeeding suggested a slightly lower food ingestion rate only in dKO mice compared with WT mice (P = 0.11; Fig. 7B, right, bottom), none of the meal pattern tests revealed significant differences. No significant changes where found regarding number of meals (P = 0.60 WT vs. dKO; Fig. 7B, left, top), duration of meals (P = 0.29 WT vs. dKO; Fig. 7B, left, bottom), or size of meals (P = 0.29 WT vs. dKO; Fig. 7B, left, bottom). When meal patterns of the first 8 h of refeeding were analyzed, the trend toward a lower food ingestion rate became smaller and completely disappeared over 24 h (data not shown).
Here we demonstrate that simultaneous deficiency for Ghr and the Ghr receptor leads to changes in energy balance, which is not observed in mice deficient for either the ligand or the receptor alone. We observed significant differences in energy expenditure, stationary locomotor activity, body weight, body fat, body length, and plasma cholesterol. We also observed substantial but mostly nonsignificant trends in glucose tolerance and insulin sensitivity. Importantly, all data presented here resulted from studies of dKO mice maintained on normal standard chow diet, whereas previous energy balance or metabolism phenotypes reported from mouse mutants with deficient Ghr signaling were observed mostly after chronic exposure to high-fat diet (29, 30, 33). Our results on the biological function of the endogenous Ghr system using three mouse mutant strains (Ghr deficient, GHSR deficient, Ghr-GHSR double deficient), indicate an additive "gene-dosage"-like effect. For most parameters in our study, Ghr deficiency had less impact on energy metabolism components than GHSR deficiency, but only simultaneous deficiency for both genes led to significant differences from wild-type (WT) control mice. These findings are consistent with both the functional relevance of constitutive GHSR activity and the putative existence of other Ghr system components, such as an additional Ghr receptor or another Ghr-like ligand.
This is the first report on an animal model with combined deletion of Ghr and the Ghr receptor genes. The most important observation may be the substantially increased energy expenditure in these mice compared with WT control mice. We were unable to verify the previously reported increase of energy expenditure in Ghr-deficient mice on chow diet (4) but rather found the additional absence of the Ghr receptor GHSR to be a prerequisite for increased energy expenditure compared with WT controls. The lack of multiple Ghr system components therefore had an additive impact on thermogenetic processes. The exact cause for the lower body weight of dKO mice cannot be easily identified on the basis of the present data. On one hand, the old mice also exhibit a modestly, but significantly, shorter body length. However, the similar body weights after 3 wk, as well as the comparable body lengths in 13-wk-old animals, do not suggest an impaired embryonic or pubertal development. Furthermore, IGF-I levels did not differ between any groups in young or old mice. In fact, the lower body weights in old and young dKO mice are unlikely to be a consequence of decreased body length alone because both changes in lean mass and fat mass contributed to the observed changes. No significant differences in lean mass were detected in old mice. Young dKO mice, albeit having the same body length, have a significantly lower lean mass compared with control mice. However, the percentage of lean tissue towards whole body mass does not differ between groups. In old mice, the lower fat mass certainly contributes to their significantly lower body weight. Supporting that notion, the lower plasma cholesterol, as well as the increased energy expenditure and locomotor activity levels, which we have observed in the dKO mice, would be consistent with a negative energy balance and decreased body fat. However, young mice, in contrast, show no changes in fat mass, at least at 13 wk of age. Further research will therefore be necessary to dissect the impact of aging on the role of Ghr signaling in the control of energy balance and body composition.
Increased locomotor activity in the absence of Ghr signaling is consistent with earlier observations, demonstrating decreased spontaneous physical activity after intracerebroventricular Ghr administration in rats (21). Furthermore, increased locomotor activity and energy expenditure was previously described in Ghr-deficient (30) and GHSR-deficient mice (33) when chronically challenged with a high caloric diet.
We here also observed tendencies toward enhanced glucose tolerance and insulin sensitivity in dKO mice. However, those differences barely reached statistical significance, and basal blood glucose and insulin levels did not differ between the four mouse strains. Our results therefore fail to further support recent studies showing that genetic deletion of Ghr in leptin-deficient (ob/ob), mice can partially rescue their diabetic phenotype (20). Since the obesity phenotype of Ghr-deficient ob/ob mice was still normal, that report had very plausibly suggested that endogenous Ghr may be more important for glucose homeostasis than for energy metabolism (20).
Finally, we speculate that the presently described mouse mutants still may exhibit some level of Ghr signaling, although Ghr (15), its putative Ghr associated peptide (31), Ghr splice variants (14), and the constitutively active Ghr receptor GHSR (13) have by definition all been genetically deleted. The existence of both an additional ligand and an additional receptor coded for by genes other than the Ghr and the GHSR gene could explain why the dKO mouse shows a phenotype that still has to be categorized as very mild (Supplemental Fig. S2).
Indirect indication for additional molecular components of the endogenous Ghr system can be derived from the studies of single gene deletion studies targeting either the Ghr ligand or its receptor (19, 20, 29, 30, 33). Although both phenotypes overall show some level of protection against high-fat diet-induced obesity on the basis of a more negative energy balance, a number of clear differences can be found when comparing published data on these two animal models, which resulted from chronic exposure to high-fat diet (30, 33). In one of the first studies on Ghr-deficient mice, they only differed from WT controls if exposed to a high-fat diet immediately after weaning and for at least 4 mo (30). Fat mass gain of Ghr receptor-deficient mice differs from WT control mice even when exposed to high-fat diet at adult age. In the presently presented studies on Ghr-deficient and Ghr receptor-deficient single gene KO mice, we partially confirm the observations of Zigman et al. (33) and Wortley et al. (29, 30), but we cannot confirm the findings reported by De Smet and colleagues (4) indicating an energy expenditure and body weight phenotype of Ghr single gene KO mice on chow diet. Increased motor activity was found in Ghr-deficient mice on a high-fat diet but not in GHSR-deficient mice on any diet (4, 30). As a matter of fact one report suggested decreased locomotor activity in mice deficient for the Ghr receptor GHSR (33). We speculate that either Ghr may act also through an additional, as of yet unknown, receptor, or that another Ghr-like ligand exists. On the basis of presently published data, this ligand is unlikely to be identical with the recently described Ghr-associated peptide, obestatin.
In summary, we conclude that Ghr has a physiological role in the regulation of energy expenditure and body weight under unchallenged environmental conditions. Future studies will have to address 1) whether the additive phenotype resulting from simultaneous deletion of Ghr and its receptor will also be apparent for other biological functions of Ghr such as learning and memory (5), 2) whether high-fat diet exposure enhances the phenotype of dKO similar to observations in mice deficient for either the Ghr ligand or the Ghr receptor, and 3) whether additional, as of yet unknown, ligands or receptors play a functionally relevant role for the endogenous Ghr system.
This research was supported by National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases Grant R01-DK069987-02 (M. H. Tschöp).
We are grateful to Kimberly Brown, Erin Grant, Nickki Ottaway, Hilary Wilson, and Rebecca Greenwald for skilled assistance.
The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
- Copyright © 2008 the American Physiological Society


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MDM Architecture Styles – Do you have the right mix?
What is the right MDM architecture style for your organization? It's definitely an open-ended question that deserves an informed answer, especially before making new investment decisions. But before tackling the question, it is useful to define and understand the MDM styles themselves. Dr. Dave Waddington of The Information Difference defined four broad styles in an article published in Information Management. If you follow the MDM space, you'll see similar descriptions from most of the MDM industry analysts.
However, most descriptions stop short of describing their applicability to specific master data domains in various industries. (Perhaps you have to pay for that?) In this blog I will summarize those styles and offer some general pros and cons for each. Subsequent blogs will cover the domains and organizational considerations in greater detail. (Hint: there likely won't be a one-size-fits-all answer for most organizations.)
So what are the MDM architecture styles you should be considering?
Consolidated – Master data is consolidated from multiple source systems into a physical golden record for downstream consumption; however, any updates made to the master data are not returned to the original sources. Consolidated MDM hubs are quick and inexpensive to set up, and offer a big return by enabling reliable enterprise-wide reporting. Data movement is typically tolerant of inter-day latency and managed through inexpensive batch processes, but it's a one-way street from source systems.
Registry – Here the master data isn't really consolidated, but is maintained as a set of "stub" records mapped to attributes stored in the source systems. There is little data movement other than the request to create or delete global stub records in the registry. The golden record is assembled dynamically using complex queries. The upside is that a real time central reference can be made with little or no infrastructure investment. The downside is that without central governance of the data the golden record isn't highly reliable.
Coexistence – Just like consolidated, coexistence harmonizes multiple sources into a physical golden record for downstream consumption. Coexistence adds the important step of updating the source systems. These requirements are typically high latency and can usually be met at an acceptable time and cost through bi-directional batch processes. Coexistence is a natural evolution of the consolidated architecture with the added benefit of linking centrally governed data back to the source systems. Interfacing with complex data sources, such as ERP systems, can become a costly drawback.
Centralized (Transactional) – While this approach also creates a physical golden record, the key differentiator from the consolidated and coexistence styles is the MDM hub extends enterprise governance over the source systems. Governing the MDM hub and the source systems together introduces shorter latency requirements that are typically addressed with a combination of web services integration and an authoring application that bridges centralized and application-specific governance needs. In most cases, this is a big step up in cost, complexity and implementation time. The pay-off is more comprehensive governance in real-time; however, too many complex sources can push cost and complexity beyond the value created by the architecture.
Most organizations we work with at Kalido start with a consolidated style and evolve to coexistence. A few may move on to the centralized style for certain data domains. In my next blog I'll discuss the circumstances when that jump from consolidated to coexistence or from coexistence to centralized might be worth considering.


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Alternative fuel
a vehicular fuel that is not entirely derived from petroleum, as natural gas, hydrogen, or an alcohol mixture:
the environmental benefits of alternative fuels.
Contemporary Examples
We took it on with green building, public transit, alternative fuel and power, recycling, and other issues.
Newsom's California Dream Matthew Dakotah October 6, 2009
a fuel other than gasoline or diesel for powering motor vehicles, often with improved energy efficiency and pollution reduction features
Electricity, natural gas, hydrogen, and fuel cells are examples of alternative fuel.
Tagged: a
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- Alternative hypothesis
(in the statistical testing of a hypothesis) the hypothesis to be accepted if the null hypothesis is rejected. Contemporary Examples An alternative hypothesis was suggested to me years ago by a veteran China-watcher. China's Clever 'Anti-Corruption' Campaign David Frum December 25, 2012 Historical Examples Podmore thinks them to have been unduly suggestible and offers hallucinations […]
- Alternative medicine
healthcare and treatment practices, including traditional Chinese medicine, chiropractic, folk medicine, and naturopathy, that minimize or eschew the use of surgery and drugs. Contemporary Examples Even Deepak Chopra, the alternative medicine and spiritual guru, preaches a dietless diet. The No-Diet Diet May Be the Key to Avoiding the Holiday Belt Bulge Erin Geiger Smith November […]
- Alternative question
a question that offers the listener a choice of two or more alternatives and is characterized by rising intonation on each alternative except for the final one, which has falling intonation, as Would you like coffee, tea, or soda?
- Alternative school
any public or private school having a special curriculum, especially an elementary or secondary school offering a more flexible program of study than a traditional school. Contemporary Examples When I was in college, I taught for a year and a half at an alternative school with behavioral-disability kids. Friday Night's Bright Light Miriam Datskovsky March […]


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Doing the Potty Dance – Questions and Answers on Potty Training with Dr. Gwenn
A year ago, I was collecting potties and prepping for one of the most intense weeks of my life. I planned on blogging a lot of it, you know, things I learned along the way, funny stories, pleas for advice and encouragement… I posted a few video diaries along the way.
But then it was OVER. And I was so OVER it.
The days that I had dreaded since seeing four heartbeats on the ultrasound machine were behind us and I was too busy celebrating our graduation into "Big Boy" status to go back and revisit how we survived it. I buried the lime green IKEA potties in the closet, donated our left over Pull-Ups, threw away the sticker charts, and gave away every potty related video/book that we had collected.
But now that my quadruplet boys have been potty trained (both day and night) for nearly a year, I'm ready to revisit the topic and share what I learned along the way. I'd love to be a resource and an encouragement to many of you going through (or preparing) for this much anticipated task. Trust me, if we can survive potty training four boys at the same time, you can do it too!
Just because we trained four at once doesn't really make us "experts", but I had the opportunity to talk with one last night. I spoke via conference call with Dr. Gwenn Schurgin O'Keeffe, who is a pediatrician, health journalist, parenting and social media expert, and is the CEO of Pediatrics Now. (Yep, that makes her the expert not little ole me!)
She addressed many common questions and concerns that moms have on potty training, and I took good notes so that I could share them with you:
- My child has no interest in potty training. What we can do to get him/her interested?
Dr. Gwenn: Some children, even at the age of 3, just aren't ready to begin the potty training process. Try looking for your child's cues on when they might be ready, as there really is no magic age for beginning the process, and consider beginning potty training at that point. It may even take the encouragement of a grandparent, teacher or other mentor to get your tot motivated.
{Personal Note: Our boys didn't show every single sign of potty training before we started the process, but they picked up on it quickly through experience. Sometimes accidents were the best way (even with the mess involved) to increase their awareness.}
- My child was having potty training success but suddenly decided that he/she no longer wants to use the potty. How can we get back on track?
Dr. Gwenn: A child may begin to demonstrate a power struggle with a parent, where the child wants to take control of the potty training process. Consider taking a break from mentioning the potty training to your child, and focus on other developmental milestones. You may find that your child takes control of the situation on his/her own altogether and has consistent potty training success.
- What's the best way to potty train at night? My child has been dry for several nights in a row. When is a good time to switch to underwear at night?
Dr Gwenn: The process of staying dry overnight is biological vs. behavioral. You can limit drinks at bedtime and/or wake the child up before you go to bed at night to encourage success. However, staying dry at night is a growth and urinary maturity issue that is very individual in nature. You can always try underwear and go back if they regress, just remember that all kids have accidents at night periodically and reassure your child throughout the transition.
{Personal Note: We transitioned to underwear at night when our boys were staying dry at night more consistently. We didn't worry about it in our initial stages of potty training. I think their best lesson was through allowing them to have accidents at night and learn through experience, without discouraging their overall success.}
- My child refuses to go #2 on the potty, but has had fabulous success otherwise. Any ideas of how to encourage her to attempt this next step?
Dr. Gwenn: There are multiple factors that can contribute to this common problem: fear, constipation, a battle of the will, leverage, etc. The big potty might be too difficult for your child, as they may need leverage and their feet on the ground. Celebrating the awareness as a success is key. Eventually they will want to and this issue will sort itself out with less pressure and anxiety.
{Personal Note: Training the boys to go #2 was almost an entirely different process. It took longer and was more difficult to predict. It also conflicted with nap schedules, which was stressful and exhausting. Try not to be discouraged over setbacks and accidents and know that this too will come along in time.}
You can find more questions and answers on the potty training process in the Advice Section of the Pull-Ups Facebook Page. Also, join thousands of moms and kids for The Pull-Ups Potty Dance Party on March 5th. You can dance along with us at the Indianapolis Children's Museum or watch the live concert from home.
Here's more details:
Potty Dance Day!
· When: Saturday, March 5, 2011; 11:30am EST – 12:30pm EST
· Where: Tune in at www.Pull-Ups.com at 11:30am EST for a special LIVE streamed concert from children's music group, Ralph's World, where they'll be performing The Potty Dance or in person at the Indianapolis Children's Museum
· RSVP: At Pull-Ups Facebook Page
What is the best advice YOU have received on potty training?
Pull-Ups has compensated me for my time and efforts in my involvement in this program, which includes talking about my experiences potty training. Additionally, the brand supplied me with upcoming reader giveaways. However, my opinions on the product and Potty Dance Day experience are entirely my own and I have not been paid to publish positive sentiments towards Pull-Ups® or their products.


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How dreamy is this purple ombre homecoming dress? Purple just happens to be one of my favorite colors, so it's crazy that this is one of the first purple homecoming dresses I've posted.
The sparkly bodice is perfection and though it's hard to see here there's even a bit of a cutout on the side of the dress.
And that skirt? It will flare up and out perfectly as you dance the night away.


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Separate names with a comma.
Discussion in 'Original Pictures Forum' started by Schrock Lawns, Feb 19, 2013.
There is an acc plug on the grandstands? Where? If u get a moment let me know. No biggie.
nice stuff
yes its a little black thing that pulls apart but i cut it off their should be a extra spot for a fuse thats wheir i wired it in
Ill have to take a look. Mine is burried in storage. Snap a pic if u can
Glad to see you expanded your equipment line up this off season. I have debated buying a 30", but i just don't feel that it is what I need right now.
If you have a 36in mower and an 21 don't get one I bought this specifically for a yard that has to be pushmowed plus I don't have a 36
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Yea I know, I was debating on replacing my 36 and 22 with two 30's, but I didn't feel that it was worth it.
Good Luck with everything this season.
You'd problay be better off with your mowers you have now. Same to you !
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Here's some stripes from the 30 their ok....
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Equipment looks good.look forward to seeing how the grandstand cuts.
It aculty stripes really really good
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Hatchet Harry GameHatchet Harry is a very violent flash game in which you have to play the role of a fascist police to extract a confession from a suspect, other by using all kinds of blows and weapons, never hurt him too much or become unconscious. A violent, but fun game. Controls: Space, AD = Action Keys
You like Hatchet Harry Game? Share it with your friends !!
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Join Couchsurfing to see sebastian_lueck's full profile. It's free!
About Me
Finding the Flying Spaghetti Monster in economy class food!
I travelled a bit after finishing school in 2011. This was my start to surf couches all over the place!
Right now I'm studying Spain for a semester abroad .
Looking forward to meet new people and friends from all over the world and listen to their stories!
Trying to take part of rescuing the world by going as much as possible by bike...very idealistic!
Live is like a box of chocolate! You never know what you gonna get!
Why I'm on Couchsurfing
I surfed couches in Australia, met heaps of people on the way.
Now I want to start hosting people while I study, show them around or do some trips on weekends!
First Couchsurfing encounter was a picinic in Melbourne in Nov. '11
So far I stayed with 4 hosts around OZ.
Been out fishing in Kalbarri, caught a nice Spanish Makerel - That's couchsurfing (Thank's Phil! )
Lived in my car in the yard and in Pauls living room for quite a while (Thanks heaps!)
Table Tennis (NOT PingPong!)
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Visiting the Philippines!
Karijini, Kalbarri, The Kimberley, Lake Argyle,...amazing places and locals!
Getting lost at night in a gorge in some remote National Park...not very smart...
Teach, Learn, Share
Would love to learn more languages, e.g. japanese or something else!
I want to learn how to fly a plane and sail!
What I Can Share with Hosts
Food and stories from around the world
Countries I've Visited
Austria, China, Croatia, Czech Republic, Dominican Republic, France, Hong Kong, Hungary, Indonesia, Italy, Macao, Malaysia, Mongolia, Netherlands, Norway, Philippines, Russian Federation, Spain, Switzerland, Thailand, Turkey, United Kingdom, United States
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Australia, Germany


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We are constantly looking for committed, responsible and competent professionals, who strive to add value and contribute to maintaining our market leadership position. At Prince's, our staff is our family and we build a conducive work environment to enhance and nurture our staff's professional and personal growth.
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Only shortlisted applicants shall be contacted. For all career opportunities listed below:
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53 Sungei Tengah Road
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Email: firstname.lastname@example.com
Contact us at 6763 7000


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Comments on the New Pottermore Shop
Next, a few comments and reviews about the new Pottermore Shop that has been launched today: Forbes – Harry Potter and the Mysterious eBookstore: First of all, you can only purchase the books from the Pottermore site. This is really … Continue reading
Posted in Press Releases, Thoughts Tagged pottermore 2 Comments
Live web chat with the Harry Potter cast!
The video web-chat begins at 3pm (BST)! Don't forget to submit your own questions to the Studio Tour from 2pm if you follow @WB_StudioTour and include the hashtag #WBSTUDIOTOUR Here is a record of the webchat. Enjoy it!
Posted in Interview, Movie Review, Personalities 9 Comments
My new thoughts about PotterMore
When Pottermore was announced two months ago, I wrote an article about it with my thoughts. Now, having already tried it, I just have to do a "mea culpa". Do I still think Pottermore is publicity stunt? Yeah, I do, … Continue reading
Posted in Personalities 20 Comments
The Geek Can Paint: The Potter Project
Keith James (or Keith Johnson) is the artist behind a some artworks in the Hp-Lexicon. I contacted him because a project I'm working on, but he told me was working in his own Harry Potter project: The Potter Project. I … Continue reading
Posted in Illustrations, Personalities Leave a comment


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"First of all, you are kind of conceited while you like to pursue danger and excitement. I've looked over all the projects of your company. Most of the projects that you have invested in are high in profit and risk. I've also noticed specifically that whenever a project started to gain profit, you would then focus on a new project. Even though you have already taken over the company for a while and overall made a profit in your projects, you don't have one project that is excellent or considered being competitive in the industry. Most of them are not bad, but not excellent either. You, by nature, like to experience risks and dangers and don't work safely and absolutely. By that, I feel that being with you have more risk financially than an average person…"
Zi Xiao is shocked and expression has become bad. He stares hard at Xu Xu but without saying a word.
Xu Xu calmly continues on, "Second, the time when Zi Xi was injured, you are the closest to her, but you didn't immediately do first aid for her. You hesitated. We've learned in middle school that whenever a vein is cut and someone starts to bleed from that we have to apply pressure to a place close to that person's heart. Why didn't you do it?
"Is it right you thought about what if you make a mistake resulting in her death? You think you thought like because you care for her? Faced with life and death, you don't have the courage to accept responsibilities…"
Zi Xiao's face darkens, "What nonsense are you saying?"
Xu Xu doesn't stop there, "Third, just then you misunderstood Ji Bai and I while we didn't have any intimacy toward each other, but your response is far more than a typical person. Why? There are two possibilities. Because Ji Bai looks very excellent; if it were an average person, perhaps you wouldn't have been that angry. This proves that you are insecure and not understanding. Another possibility is that you are very possessive. In the past, did any of your girlfriends break up with you because of your possessiveness?
"Fourth, you always care about appearance. Whenever we meet, you would always take care of your appearance from head to toe. There is also news about you on the Internet saying all of your girlfriends are beautiful.
"Seeing Yao Meng back then, you were clearly distracted. Of course, it is normal for men to like beautiful women. But you were angered back then; it would be difficult to be distracted. However, you got mesmerized by Yao Meng, this proves that you have a higher interest and excitement of women than normal men. You like to pursue exciting and new, moreover, you grew up in the state with the easygoing environment; my guess is that you had relationships that are just physical, right?
"So why do I have to accept a man who is irregular, impatience, and can't face responsibility in the urgent situation, and also have a chance that you will go to bed with another woman at any time?"
After leaving the track field, Xu Xu returns to the restaurant.
She doesn't feel pleasant on the inside.
Although soon after meeting him she made her decision about Zi Xiao, She always felt that she shouldn't say all those words because it would hurt.
Xu Xu depressingly pushes the restaurant's door. At this time, the place is pretty packed with people. Ji Bai still relaxingly sits at the place.
"Where is Yao Meng?" Xu Xu asks.
"She left," Ji Bai replies.
"Oh." Xu Xu picks up her purse on the chair. She knows that Ji Bai purposely waited for her to return. "Thank you."
Ji Bai stands up, Xu Xu follows. He doesn't say anything so she also doesn't say anything. The two are one step away from each other, silently walk outside.
The morning's sunlight shines over the clean streets. Xu Xu looks up and immediately sees Ji Bai's big figure, overshadowing her sight. His steps are calm, neither fast nor slow.
For some unknown reason, just silently walking like that helps Xu Xu's chaos state of mind quickly disappear and replaces it with calm and warm feelings.
The two reach the parking lot to take their own cars and go on their way.
Xu Xu turns to Ji bai to say good-bye like usual. "Ji Bai, see you tomorrow."
Ji Bai already figured that Xu Xu wouldn't give him any explanation for the way she "kicked" him like that. But her face is very natural right now, not showing any kind of timidity….
"You thought about whether we are suitable or not? " Ji Bai suddenly speaks up in a low tone.
Xu Xu is stupefied.
She said that just then because she doesn't want to find a boyfriend who is an officer, that's why Ji Bai is not suitable. Now that Ji Bai asks like that, even as a slow person, she knows that what she said is clearly "outrageous". (1)
About to explain, Xu Xu saw the faint smile in Ji Bai's black eyes.
"About that…" Xu Xu isn't able to finish the sentence before Ji Bai turns around and walks away.
Zi Xiao drives fast, like flying, home. Looking at the signs quickly out of sight on the free way, his heart changes with the surrounding from furious to dejected and hopeless.
There weren't any woman who criticized him that harshly, every sentence every word heavily placed on him without hesitation.
From young, Zi Xiao was already a "son of the world". His family background taught him, and people like him, how to socialize with people, also learned trickery for benefits, thus living a life that is above others of the same age.
Xu Xu's words like a sharp knife stabbed into Zi Xiao's heart and cut to pieces the fake layer of money, making him feeling furious, then vulnerable.
Because what she said is exactly true. Because deep on the inside, Zi Xiao knows what kind of person he is.
One hour later, Zi Xiao got home. Everyone is present; his father, his big brother's family, second sister's family, third sister's family, and Zi Xi. Seeing Zi Xiao's depressed look, his third sister smiles, "Who caused trouble with our family's young boss?"
Ye Lan speaks up to suggest, "Come here to eat."
Zi Xiao just looks at Zi Xi with indifferent tone of voice, "That day, I'm truly sorry."
Zi Xi is perplexed, but Zi Xiao already turned around and walks away.
That night, Zi Xiao received a phone call from a couple of friends telling him to come to the bar "Colorful". This bar has good wine and beautiful women, a favorite place of sons of rich families.
Reaching the place, Zi Xiao returned to normal, just not as talkative as usual. A friend sees that he is not quite happy so immediately winks at the woman sitting next to him. She is the youngest daughter of a business family in the city, and has liked Zi Xiao for a long time. She holds up the cup of wine. " Zi Xiao, you came here to play so you should forget all of you troubles. Seeing you like this is very painful for me."
Zi Xiao looks at the blurry face and the full body of the woman. Xu Xu's words suddenly pop up in his head, "Why do I have to accept a man like you?"
He immediately wraps his arms around her neck and kisses her.
After that, the two of them reserve a room. While crazily at it with the woman, Zi Xiao thought to himself, "Xu Xu, what you said is exactly right, I am that type of man. You made me feel very uncomfortable, and very miserable."
The weather is very nice the next day, when Xu Xu reaches the track field the sky is the color of clear ocean blue like a fabric covering the earth.
While running, Xu Xu is a bit distracted. She thought about calling Zi Xiao to comfort him a little bit. But remembering his conceited personality, if she were to call then it is as if pouring oil into the fire, everything she said would be in vain. Let's see what happened, then decide.
After running for two laps, Xu Xu sees that Ji Bai ahead suddenly stops, looks down to hear a phone call. Seeing his back damp with sweat make her remember what he said yesterday.
She heard from Zhao Han that Ji Bai really hates being follow around by women. She really needs to explain to him that she isn't aimlessly dreaming. She said not suitable because of his occupation as an officer. Truthfully, he could be seen as someone working in the science field. He has outside appearance and is strong with determination and sharp…
All of this analyze passes fast by Xu Xu's brain. She doesn't have time to think deeply about it before she could hear fast footsteps coming from behind. For the next seconds, she could feel a body full of sweat is coming fast close to her. Not waiting for her to run back, her collar is grabbed and her still running legs stopped. Xu Xu's collar got pulled by Ji Bai.
"What are you doing?" Xu Xu furrows her brows while turning back.
Ji Bai's face is full of sweat, his expression is dark, and his black eyes are spreading cold air.
"Quickly follow me. At house 3, street DM, mountain LA, a dead body of a woman was found."
Xu Xu jolts. Ji Bai stops for a moment before continuing to say, "The dead person is Zi Xi."
(1) It makes it seem like she thinks Ji Bai likes her or something.


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Steampunk for V4
Lead your Victoria 4 character down the path not taken with the SteampunK outfit! Give your girl's wardrobe a Victorian-era twist with this new "must have" clothing set. Varying textures allow you to customize your model's look from head to toe – from fancy and fashionable to the risqué. SteampunK comes with multiple morphs and has 9 conforming pieces, including hat and boots! So don't delay; retro-fit your V4 character with SteampunK today!
Product Requirements: Poser5 and up, V4.2 A4 Elite Morphs++ and/or GND4


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Pulupot Trailer (2010)
Pulupot tells the story of Eva (Justine Ferrer), a hardworking transsexual enterpreneur waiting for Edgardo (Gio Gapas), the love of her life while his life is currently enmeshed in a complicated relationship with Kiko (Justin de Leon), a possesive gay man. , a pragmatic sex worker Kristel (Echo Caceres) and his OFW girlfriend Cora (Joyce Acorda).
Watch the official Pulupot 2010 trailer in HD below or find more Pulupot videos on Vidimovie.


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