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Create a Compelling Call-To-Action For Your Teleseminar
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Fecha de Publicacion: 11/11/2015
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Dagan, also spelled Dagon, West Semitic god of crop fertility, worshiped extensively throughout the ancient Middle East. Dagan was the Hebrew and Ugaritic common noun for "grain," and the god Dagan was the legendary inventor of the plow. His cult is attested as early as about 2500 bc, and, according to texts found at Ras Shamra (ancient Ugarit), he was the father of the god Baal. Dagan had an important temple at Ras Shamra, and in Palestine, where he was particularly known as a god of the Philistines, he had several sanctuaries, including those at Beth-dagon in Asher (Joshua 19:27), Gaza (Judges 16:23), and Ashdod (1 Samuel 5:2–7). At Ras Shamra, Dagan was apparently second in importance only to El, the supreme god, although his functions as a god of vegetation seem to have been transferred to Baal by about 1500 bc.
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The perfect Malas for me.
I have wanted a skull Mala for a very long time. I am very pleased with these. They are beautiful, the quality is great and I love that they are big enough to wear comfortably around my neck. I certainly recommend them. They also arrived in a timely manner. I will certainly shop more with you. Thank You.


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"Invaluable support from Social Inclusion Team"
About: Nottinghamshire Healthcare NHS Foundation Trust / Adult mental health (inpatient) Nottinghamshire Healthcare NHS Foundation Trust Adult mental health (inpatient) NG3 6AA
Posted by Happily613 (as ),
I have had a mental health condition for the last 20 years. I have worked intermittently throughout. Unfortunately, I have never been able to sustain employment for long periods. This has largely been due to illness, negative and unsupportive attitudes on employers and colleagues. Previous back to work programmes have been linked to colleges; personal development programmes and voluntary work.
Presently I am making preparation to return to work. For the first time thorough a referral from my psychiatrist I have the support of a social inclusion worker (disability employment advisor) from the social liaison team- Nigel. For the past 6 months have received invaluable support in terms of practical and emotional support from Nigel. This person centred approach has enabled me to explore my career prospects in light of this economic climate.
Nigel provided me with excellent welfare advice in terms of disability return to work benefits and was able to guide me e. g. interview techniques and questions. The flexibility in his availability has also been very good e. g. recently he was a phone call away in answering queries re: my work contract.
Generally, I have found this service inclusive in locating our meeting in local venues and enabling me to set my own agenda. I also consider the prospects of Nigel's continued support during the first few months of my new job as invaluable in relieving anxieties and helping with the adjustment period from long period of illness to full time work.
Response from Jane Danforth, Involvement Team , Involvement & Experience, Nottinghamshire Healthcare NHS Trust 5 years ago
Dear Happily613
What a great story! I am sure that this will inspire others to persevere and it just goes to show how effective practical and emotional support can be in helping recovery.
I have passed on your posting to Nigel and the Team
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Innovative Technology Announces 13 New Retail Partners for the Justin Power Case
Retailers across North America provide consumers with on-demand power this holiday season by rolling out the slim tablet case with built-in rechargeable battery to deliver ample power in a stylish solution.
Port Washington, NY - November 26, 2013 - Innovative Technology™ (IT), a rapidly growing manufacturer of audio and video systems and accessories for smartphones, tablets, and other mobile devices, announces 13 new retail partners to carry the recently expanded Justin™ Power Case line. The previous iPad® model is joined by a new universal-size model, designed to fit any size tablet and is perfect for the executive traveler, student or commuter who needs to keep multiple mobile electronics devices powered up anywhere they go.
Tablet and smartphone sales boomed in 2013, elevating mobile device accessories to record highs. According to ABI Research, smartphone accessory sales are estimated to increase to $38 Billion by 2017 . Major retail outlets have taken advantage of the increased sales of connected devices such as tablets and smartphones by partnering with Innovative Technology to sell powerful accessories by choosing to sell the Justin Power Case line.
The retailers with agreements to sell the Justin Power Case in stores and online include:
• Amazon
• Bed Bath & Beyond
• Bonton including: Bergner's, Boston Store, Carson Pirie Scott, Elder-Beerman, Herberger's and Younkers
• Kohl's
• Lord & Taylor
• Macy's
• RadioShack
• Shopko
• Staples Canada
• The Source Canada
• Wal-Mart Canada
"We are proud to work with such well-known retail outlets to get our Justin Power Case out to consumers. As tablet sales persist, portable accessories are accelerating and driving high-profit margins. After a year of massive growth in tablet adoption, this holiday season is the time for retailers to capitalize on the "power-hungry," connectivity wants and needs of the holiday shopper - as they buy accessories for their own portable device and everyone on their list," said Corey Lieblein, Innovative Technology Founder & CEO. "I see the growing consumer demand for portable power making this a prosperous season for portable power and we are fortunate to have a number of major retailers making our Justin Power Case a top space in their stores."
The Universal Justin Power Case by Innovative Technology is a patent-pending power solution that pairs a stylish, lightweight tablet case with a built-in 11,600mAh rechargeable lithium-ion battery. It is also available in the original iPad® size. It features a universal USB charging port with a built in, slim-line battery that can quickly and easily charge the tablet within, as well as additional devices including smartphones and MP3 players. The 11,600mAh rechargeable battery is the equivalent to having your device powered by 11 AA batteries and packs enough power to recharge any size tablet twice or smartphone up to seven times. "No outlet? No worries!™ The Justin Power Solution is both stylish and lightweight, the perfect combination for connected consumers on the go.
The Justin Power Case by Innovative Technology is available now at the retailers listed above. MSRP is $69.99 and the case is available a myriad of styles and colors.
For more information about Innovative Technology, visit www.ithomeproducts.com.
About Innovative Technology
Innovative Technology is a fast growing manufacturer that specializes in the design, manufacturing, and distribution of distinctive consumer electronics and mobile technology accessories for home entertainment, mobile lifestyle and gaming enthusiasts. Innovative Technology was founded in 2002 to bring high-quality and stylish consumer electronics to meet the rising demand for the digital lifestyle. Now a multi-national company with offices in New York and Hong Kong, our multilingual, dedicated team supporting over 200 products sold in more than 25,000 retail outlets throughout North America, and customers around the world, Innovative Technology continues to accelerate its design and engineering of distinctive CE devices and expects to launch more than 200 new products by 2014.


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$100 Antigua GOLD & SILVER Banknote Ships & Pirates "William Taylor & Victory
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You are bidding on anAntigua & Barbuda $100 23K Gold & Silver Legal Tender Banknote "The World's First Gold & Silver Banknotes" and "The Saga of Treasure Ships and Pirates" This note is "CAPTAIN WILLIAM TAYLOR & THE VICTORY" These are a Limited Edition of 20,000 These notes were made in 1988 and are Legal tender in Antigua & Barbuda The note comes on an A4 sheet with information about the Ship & the note is in a clear plastic mount. As at 3/1/13 the exchange rate for the East Caribbean Dollar (XCD) $100 was worth £22.71 (GBP) Plus not forgetting the gold & silver content. Great collectable OR alternatively if you are going on holiday to Antigua you can always spend them!! PLEASE SEE OTHER LISTINGS AS I WILL BE LISTING 25 OF THESE This item will be sent special delivery. For insurance purposes (postage can be combined) Any questions or more photos please ask. Sold as seen having a clearout please see other items. PayPal from confirmed address only, if unconfirmed payment to be made by direct bank trf (internet banking)


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Graft-versus-host disease is one of the major transplant-related complications in allogeneic hematopoietic stem cell transplantation. Continued efforts have been made to prevent the occurrence of severe graft-versus-host disease by eliminating or suppressing donor-derived effector T cells. Conventional immunosuppression does not adequately prevent graft-versus-host disease, especially in mismatched transplants. Unfortunately, elimination of donor-derived T cells impairs stem cell engraftment, and delays immunologic reconstitution, rendering the recipient susceptible to post-transplant infections and disease relapse, with potentially lethal consequences. In this review, we discuss the role of dynamic immune regulation in controlling graft-versus-host disease, and how cell-based therapies are being developed using regulatory T cells and other tolerogenic cells for the prevention and treatment of graft-versus-host disease. In addition, advances in the design of cytoreductive conditioning regimens to selectively target graft-versus-host disease-inducing donor-derived T cells that have improved the safety of allogeneic stem cell transplantation are reviewed. Finally, we discuss advances in our understanding of the tolerogenic facilitating cell population, a phenotypically and functionally distinct population of bone marrow-derived cells which promote hematopoietic stem cell engraftment while reducing the risk of graft-versus-host disease.
Graft-versus-host disease (GVHD) remains a major obstacle for the clinical application of hematopoietic stem cell (HSC) transplantation [1]. GVHD is initiated by alloreactive donor T cells which recognize the host minor and major histocompatibility (MHC) antigens, proliferate, and damage target tissues. Donor T cells have been shown to enhance engraftment of HSC, reconstitute T cell immunity, and mediate a potent beneficial anti-tumor effect, known as graft-versus-leukemia (GVL) effect. Depletion of donor T cells impairs engraftment of HSC and abrogates the T cell-mediated GVL effect. In addition, administration of immunosuppressive drugs to prevent GVHD after HSC transplantation impairs T cell function and increases the risk of opportunistic infection and tumor relapse. Therefore, recent approaches have focused on tailored approaches to maintain the desirable effect of GVL yet avoid GVHD after HSC transplantation. Recent preclinical novel cell-based therapies have been developed to achieve these outcomes. They are currently being translated to the clinic.
The mechanisms of donor T cell (CD4+ T cell and CD8+ T cell)-mediated GVHD are multifactorial and include activation of macrophages and antigen-presenting cells (APC) by transplantation conditioning regimens to damage host tissue, releasing soluble cytokines such as TNF-α and IL-1; alloreactive T cell activation, proliferation and differentiation in response to host or donor APC; and alloreactive T cell infiltration and release of pro-inflammatory cytokines which leads to damage of the target tissue [2]. Over the past two decades, the importance of regulatory populations of lymphocytes in controlling immune responses has been increasingly appreciated. Although different cell subsets with regulatory activity have been described, including CD4+/CD25+/forkhead/winged helix transcription factor + (FoxP3+), CD8+/CD28-, T/natural killer (NK) cells, and TCR+/CD4-/CD8-, most studies have concentrated on CD4+/CD25+/FoxP3+ T cells [3]. Among the CD4+ T cell population, CD4+/CD25+/FoxP3+ regulatory T cells (Treg) have been demonstrated to suppress a variety of immune responses dependent on effector T cells.
CD4+ Treg have been divided into two major groups: the naturally occurring Treg and inducible Treg. Both types of Treg have proven effective in preventing GVHD in murine models of GVHD [4,5] and, to a lesser extent, in human HSC transplantation [6-8]. Although studies have suggested that Treg downregulate both T helper 1- and T helper 2-mediated immune responses, mainly through IL-10 and transforming growth factor beta (TGF-β) production, direct cell-cell contact has also been postulated to be required as a mechanism of action. Natural Treg are generated in the thymus and are nonspecific in their suppressive capability [3,9]. Although natural Treg must encounter antigens to exert their suppressive effects, once activated they suppress in an antigen-nonspecific manner, presumably through the release of immunosuppressive cytokines such as IL-10 and TGF-β [10]. Because of their nonspecific mechanism of action, there is concern regarding their clinical relevance. Importantly, antigen-specific Treg are inducible and need to be activated through their TCR in order to mediate their suppressive activities. The expression of receptors of chemokines, such as C-C chemokine receptor type 5 (CCR5) and CXC chemokine receptor 3 (CXCR3), on antigen-specific Treg support a role for proper trafficking of Treg to target tissue in the prevention of acute GVHD in murine models [11,12]. A recent study showed that tolerant patients without GVHD after HSC transplantation expressed significantly higher levels of CCR5 and CXCR3 compared with patients with acute GVHD early after HSC transplantation [8], suggesting that homing of Treg to secondary lymphoid tissues and sites of inflammation may play an important role in the control of GVHD.
Several studies in experimental murine models have shown that Treg can suppress proliferative activity of conventional CD4+ T cells and CD8+ T cells to alloantigenic stimulation in vitro and induce transplantation tolerance and reduce acute GVHD occurrence in vivo [13-15]. Donor CD4+/CD25+ Treg isolated from the spleen or bone marrow of C57BL/6 mice can suppress lethal GVHD induced by transplanted donor CD4+/CD25- T effector cells after allogeneic T cell-depleted bone marrow transplantation (BMT) [14]. Importantly, the beneficial effect of adoptively transferred CD4+/CD25+ Treg does not abrogate the beneficial effect of donor T cell-mediated GVL [13]. Ianni et al. recently evaluated the impact of early infusion of freshly isolated human donor CD4+/CD25+ Treg followed by conventional T cells in human leukocyte antigen (HLA)-haploidentical HSC transplantation [16]. Adoptive transfer of human donor Treg prevented acute as well as chronic GVHD in the absence of immunosuppressive drug therapy after transplantation. Moreover, Treg promoted immune reconstitution of CD4+ T cells, CD8+ T cells, B cells, and NK cells, and improved protective immunity against cytomegalovirus infection.
The major limitation for the clinical application of Treg-based therapy to prevent GVHD is obtaining sufficient numbers of antigen-specific Treg and maintaining their regulatory properties after infusion [17]. Studies showed that ex vivo expansion of mouse recipient-specific CD4+/CD25+ Treg can be obtained using donor Treg stimulation with allogeneic recipient APC [18,19]. Ex vivo expansion of Treg resulted in specific tolerance for recipient-type alloantigens, but not for third-party antigens. Moreover, the Treg effectively controlled GVHD while favoring immune reconstitution and maintaining GVL in a murine model [18]. Another study showed that rapamycin-induced Treg from human CD4+/CD25-/CD45RA+ cells exhibit a potent suppressive function in vitro compared with natural Treg, and suppress acute GVHD in a xenogeneic NOD/SCID mouse model [20]. Clinical trials of therapeutic cell transfer using Treg for the prevention and/or treatment of GVHD have recently been described. Ianni et al. reported that the adoptive transfer of freshly isolated, donor-derived natural Treg followed by conventional donor-derived T cells (Tcon) at the time of full-haplotype-mismatched adult HSC transplantation in patients being treated for hematologic malignancies prevented acute or chronic GVHD while favoring Tcon-mediated post-transplantation immune reconstitution [16]. Brunstein et al. detailed a 'first-in-human' phase 1 clinical trial of nonspecific (CD3/CD28 bead)-based ex vivo expanded umbilical cord blood-derived Treg in patients after umbilical cord blood transplantation and noted a reduced incidence of severe acute GVHD [21].
Treg as diagnostic and prognostic cellular biomarkers for acute GVHD have been investigated in mouse and rat models and human HSC transplantation [22-25]. Studies reported that the level of FoxP3 mRNA expression in peripheral blood mononuclear cells from patients with either acute GVHD or chronic GVHD was significantly decreased compared with patients without GVHD [25,26], suggesting that a regulatory mechanism is involved in the development of GVHD. The number of FoxP3+ Treg in skin biopsies from GVHD patients was significantly higher in patients responding to GVHD treatment and with a lower grade of GVHD compared with those with more severe GVHD [23]. Taken together, these observations indicate that Treg can regulate immune responses and induce tolerance to alloantigen after HSC transplantation. These findings provide evidence for the use of Treg as a useful biologic to improve GVHD diagnosis and treatment.
In GVHD, functional immune cells in the donor bone marrow recognize the recipient as foreign and mount an immunologic attack on the patient's organs and tissues, impairing their ability to function [1]. Strict HLA matching between donors and transplant patients has been proven to reduce the incidence and severity of GVHD [27]. However, approximately 50% of patients still develop GVHD even if they undergo allogeneic HSC transplantation with HLA-matched donors [28]. The challenge facing HSC transplantation is to achieve better allogeneic engraftment without graft rejection and GVHD. The common reagents of GVHD prophylaxis comprise cyclosporine, or tacrolimus, methotrexate, mycophenolic acid, or sirolimus [29-31]. However, cyclophosphamide has been found more recently in animal and clinical studies to be a better and potent prophylactic agent of GVHD without obvious aplasia due to toxicity to donor stem cells [32-36]. When it is used in high dose after allogeneic BMT in mouse models, cyclophosphamide targets alloreactive proliferating T cells and enhances alloengraftment without causing GVHD [32-34]. Therefore, in order to gain the effect of cyclophosphamide in enhancing alloengraftment, it has to be used 48 hours after BMC infusion but not before [32]. High-dose cyclophosphamide given on day 2 after transplantation mitigated both the incidence and severity of acute GVHD in an MHC-mismatched donor-recipient combination [37]. The effect of post-transplantation cyclophosphamide in GVHD prevention has been demonstrated by inhibiting graft-versus-host reactions and selectively eliminating activated T cells in response to donor antigens in minor histocompatibility disparity [38] and MHC-mismatched [33] mouse models. Clinically, post-transplantation cyclophosphamide has reduced the incidence and severity of GVHD across MHC barriers after BMT [33-35,39,40]. High expression of aldehyde dehydrogenase in HSC allows for the prompt inactivation of cyclophosphamide and helps explains their relative resistance to the effects of this alkylating agent. In contrast, activated lymphocytes express low levels of aldehyde dehydrogenase and are particularly susceptible to cyclophosphamide. Importantly, these preclinical studies demonstrated the specific safety profile of cyclophosphamide in stem cell-sparing activity, thus provided the preclinical rationale to proceed with a clinical trial of partially HLA-mismatched or HLA-haploidentical BMT with high-dose post-transplantation cyclophosphamide for patients with poor prognosis hematologic malignancies.
The major clinical rationale for HLA-haploidentical BMT is to extend the potential benefits of HSC transplantation and the graft-versus-tumor effect to patients who lack an HLA-matched donor. The major challenge is to reduce the incidence of fatal graft rejection, severe GVHD and treatment-related mortality while promoting engraftment. Luznik et al. recently reported the outcomes of 68 patients with poor-risk hematologic malignancies who were conditioned with fludarabine, cyclophosphamide and 2 Gy total body irradiation prior to receiving T cell-replete bone marrow from HLA-haploidentical, first-degree relatives [36]. Donors and recipients were mismatched at a median of four out of five HLA alleles, indicating substantial donor-recipient histoincompatibility. GVHD prophylaxis comprised intravenous cyclophosphamide 50 mg/kg on day 3 (n = 28) or on days 3 and 4 (n = 40) after transplantation, followed by tacrolimus and, mycophenolic acid. These two drugs were included to provide extra protection against graft failure and GVHD. They were started after the completion of cyclophosphamide in light of preclinical data indicating that calcineurin inhibitors block cyclophosphamide-induced transplantation tolerance by blocking the activation and proliferation of alloreactive T cells [41]. Recovery of neutrophils and platelets occurred at a median of 15 and 24 days, respectively, after transplantation. Graft failure occurred in nine patients (13%). Acute grades II to IV occurred in 34% and III to IV GVHD in 6% of patients, and chronic GVHD developed in 15% of patients. These rates of GVHD development are comparable to or below the incidences of acute and chronic GVHD after HLA-matched HSC transplantation without post-transplantation cyclophosphamide [42]. One year after transplantation, the cumulative incidence of relapse mortality was 51% and non-relapse mortality was 15%, and overall survival and event-free survival at 2 years after transplantation were 36% and 26%, respectively. Only six patients died, four of infection and two of GVHD. These data support the safety and potential efficacy of post-transplantation cyclophosphamide in preventing GVHD and fatal graft rejection after HLA-haploidentical HSC transplantation.
Based upon the results of Luznik and Fuchs [35,36,39], we have included the use of post-transplant cyclophosphamide (50 mg/kg day, 3 days after BMT) as part of a non-myeloablative conditioning regimen being used in an ongoing phase 2 trial of tolerance induction in recipients of mismatched kidney and stem cell transplants. Durable donor chimerism has been achieved in five of the first eight participants and no patient has developed GVHD [43].
T cell depletion (TCD) of allogeneic bone marrow is extremely effective at reducing the risk of GVHD, but greatly increases the risk of engraftment failure. Three possible reasons for TCD-associated-engraftment failure have been hypothesized. First, HSC can engraft across MHC-matched but minor disparate barriers, but fail to engraft in allogeneic recipients because they are harmed or removed during TCD. Second, T cells act as essential partner cells to promote allogeneic HSC engraftment. Third, an additional bone marrow population that shares some T cell markers protects the HSC from rejection or 'facilitates' HSC engraftment, but is inadvertently removed as an 'innocent bystander' during TCD. Investigations in different laboratories have provided strong evidence in support of the latter hypothesis. Initial studies in mice using different cell subsets sorted from donor bone marrow identified a distinct population of CD8+/TCR- facilitating cells (FC) capable of promoting allogeneic HSC engraftment and establishment of mixed chimerism [44]. The addition of 30,000 MHC-matched purified FC to as few as 10,000 donor HSC into ablated MHC-disparate B10 recipients resulted in stable allogeneic engraftment across both class I and class II barriers, without causing GVHD [44]. Transplantation of FC alone failed to rescue recipients, indicating that FC are not an HSC. Importantly, FC + HSC reconstituted animals exhibit donor-specific tolerance for skin, cardiac and islet grafts.
In light of the fact that FC function is distinct from that demonstrated by bone-marrow-derived mature T cells, much research has gone into identifying the resident cell subpopulations that constitute this rare facilitating population. Previous studies have shown that the CD8+/TCR- FC population shares phenotypic characteristics with CD8α plasmacytoid precursor dendritic cells (p-preDC) and that total FC are heterogeneous in morphology [45]. A comprehensive assessment of FC surface markers using flow cytometric analysis of sorted FC populations by Fugier-Vivier et al. [46] revealed a broad heterogeneity in subpopulations with facilitating potential. The majority of CD8+/TCR- FC were positive for CD11c+ (65% to 70%) and B220+ (75% to 88%) expression. While only 15% of the B220+ population was composed of B cells, 55% co-expressed CD11c (CD11c+/B220+), suggestive of a dendritic cell component. Further analysis into this CD11c+ dendritic subset revealed that a p-preDC phenotype (CD11dim/B220+/CD11b-) is the predominant cell type (93% to 95%) within this CD11c+ subset (Figure (Figure1).1). The functionality of this p-preDC-like subset of FC has been assessed by transplanting these cells with HSC into ablated murine allogeneic recipients. The co-transplantation of p-preDC rescues allogeneic recipients from radiation aplasia, significantly enhancing alloengraftment and survival compared with ablated recipients that received HSC alone. However, facilitation by this p-preDC component alone was inferior to that observed when the entire FC population was utilized. This observation suggests that the p-pre DC subset is necessary, but not sufficient, for HSC facilitation and cannot fully replace the total FC population. Other elegant studies by Taylor et al. indicate that CD3e expression by FC and the association of CD3e with TCRβ chain and a novel 33 kDa protein termed FCp33 is critical for the HSC engraftment enhancing properties of FC [47].
Recent studies have focused on exploring FC and seeking to understand their role in generating tolerance. One such study completed on mice consisted of three groups of purified bone marrow inocula, which contained different subsets of CD8+ cells that were administered to semi-allogeneic recipient mice [48]. The first group was αβ-TCR+ splenic T cells, the second group was the CD8+/TCR+ bone-marrow-derived T cells, and the third group was the bone-marrow-derived CD8+/TCR- FC population. The purpose behind this experimental setup was to determine which group of cells would induce GVHD in the recipient mice. There were several important findings that resulted from this study [48]. The first was disproving the common belief that administering donor CD8+ T cells would enhance engraftment and prevent the development of GVHD. This idea is supported by the fact that mice in the first and second groups of the experiment developed lethal GVHD, while mice in the group that received FC failed to develop clinical symptoms or histological evidence of GVHD [48]. Additionally, the researchers reported failure of FC to induce GVHD in mice when the number of FC transplanted was increased from 50,000 to 400,000, confirming that FC lack GVHD effector activity. Researchers also explored the mechanism behind the lack of GVHD development with transplantation of FC versus transplantation of the CD8+/TCR+ bone marrow cells [48]. The results from such studies found an increase in the expression of T-cell-mediated immunosuppression factors. In particular, mice that received HSC with FC showed a significant increase in the transcription of TGF-β, a cytokine known to be a key player in the induction and development of Treg. There was also a considerable increase in the expression of the cyte-associated antigen 4, glucocorticoid-induced TNF receptor and FoxP3 genes, which are associated with Treg and suppressor T cell function. It was concluded that FC induce the formation of immunoregulatory T cells in vivo, since the FC is not a Treg and does not express the genes linked to Treg [48].
The ability of FC to induce the formation of CD4+/CD25+ Treg from naive CD4+/CD25- T cells, as shown in one recent study, is another proposed mechanism of how FC promote tolerance [49]. CD4+/CD25+ Treg cells have been found to promote bone marrow engraftment and chimerism when transplanted into irradiated recipients [49]. Additionally, CD4+/CD25+ cells are thought to prevent the development of GVHD after allogeneic transplantation. Both of these observations are similar to those observed with BMT containing FC. This has lead researchers to consider an association between FC and CD4+/CD25+ Treg in inducing tolerance and preventing GVHD [49].
It was believed that p-preDC were the primary activators of naive CD4+/CD25- T cells; however, Taylor et al. have shown that FC possess this function as well [49]. The Taylor study involved mice receiving an allogeneic HSC plus FC transplant and measuring the induction of FoxP3+/CD4+/CD25+ by FC. Three major observations were made by this group that expanded the scientific knowledge of FC. The first was that donor FC were observed in the spleen shortly after transplantation and the induction of donor FoxP3+/CD4+/CD25+ Treg also occurred in the spleen. Since p-preDC activate Treg in the spleen, the presence of FC in the spleen prior to activation of Treg supports the notion that FC activate Treg. The second was the observation that FC could induce the formation of FoxP3+/CD4+/CD25+ Treg from CD4+/CD25- T cells in co-culture. The researchers proposed a mechanism of activation of FC similar to that of p-preDC, to generate FoxP3+/CD4+/CD25+ T cells. However, higher levels of IL4 gene expression were observed with FC-generated CD4+/CD25+ T cells in comparison with p-preDC-generated T cells [49]. The last significant observation was that FC required direct cell-to-cell contact to induce the formation of FoxP3+/CD4+/CD25+ Treg. Fewer FoxP3+/CD4+/CD25+ cells were produced in the absence of physical contact than when direct contact occurred between the FC and the CD4+/CD25- T cells [49]. Recent studies have suggested that the differentiation of CD4+/CD25- T cells into CD4+/CD25+ T cells requires stimulation from various sources [49]. The B7 receptor is one important aspect of this activation process since studies have demonstrated a lower number of CD4+/CD25+ T cells in mice with a B7 deficiency [49]. CD86 is thought be another important player in assisting FC to produce FoxP3+/CD4+/CD25+ Treg because its presence is required for differentiation [49]. More recently, FC have been shown to induce antigen-specific Treg in vivo (Figure (Figure2)2) [50]. Transplantation of FC plus HSC into conditioned allogeneic mouse recipients followed by harvest of CD4+/CD25+ Treg from the spleen of chimeras (chimeric Treg), and secondary transplantation of the Treg with donor HSC plus third-party HSC resulted in engraftment of only the donor HSC, demonstrating antigen-specificity.
In recent years there have been significant advances in understanding the mechanism of FC function, which have provided additional support for the promising potential for FC to be used in the clinic to generate tolerance after HSC transplantation. Data collected from recent studies have helped to distinguish FC from other hematopoietic cells such as p-preDC. However, there are questions that remain to be answered regarding the role of FC in inducing tolerance, preventing GVHD and promoting chimerism following BMT. A phase 2 clinical study approved by the Food and Drug Administration is currently underway to test the use of FC-based HSC transplantation in recipients of living donor renal allografts. Preliminary findings have demonstrated that high levels of donor macrochimerism without GVHD can be established in mismatched recipients conditioned with fludarabine, cyclophosphamide and 200 cGy total body irradiation [51].
The use of cell-based therapies in the prevention and treatment of GVHD is now being applied in a number of clinical protocols, with promising results. Cell-based therapies have the potential to promote engraftment, preserve immunocompetence and prevent GVHD, thereby avoiding the toxicity of broad acting nonspecific immunosuppressive agents.
APC: antigen-presenting cells; BMT: bone marrow transplantation; CCR5: C-C chemokine receptor; CXCR3: CXC chemokine receptor 3; DC: dendritic cells; FC: facilitating cells; FoxP3: forkhead/winged helix transcription factor; GVHD: graft-versus-host disease; GVL: graft-versus-leukemia; HLA: human leukocyte antigen; HSC: hematopoietic stem cell; IL-1: interleukin-1; MHC: major histocompatibility complex; NK: natural killer; p-preDC: plasmacytoid precursor dendritic cells; TCD: T cell depletion; Tcon: conventional donor-derived T cells; TCR: T cell receptor; TGF-β: transforming growth factor beta; Treg: regulatory T cell; TNF-α: tumor necrosis factors-α; UCB: umbilical cord blood.
STI has significant equity interest in Regenerex, LLC, a start-up biotechnology company based on the facilitating cell technology. All other authors have no conflict of interest to declare.
JL: overall preparation and editing of review; YH: studies on role of Treg cells in GVHD prevention; HX: studies on role of cyclophosphamide; IG: review of FC mechanism of action; STI: overall editing and preparation of review. All authors have read and approved the final manuscript.
The pre-publication history for this paper can be accessed here:
The authors thank Dr. Haval Shirwan for a review of the manuscript and helpful comments; Dr. Yujie Wen for extensive reference research; and Carolyn DeLautre for manuscript preparation. This work was supported in part by the following grants: NIH R01 DK069766 and NIH 5RO1 HL063442. This publication was also made possible by Award No.W81XWH-07-1-0185 and W81XWH-09-2-0124 from the U.S. Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick, MD,21702-5014 (Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the Office of Army Research); and the Commonwealth of Kentucky Research Challenge Trust Fund.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Computed tomographic screening for lung cancer: home run or foul ball?
Related Articles
- Helical CT helps in reducing mortality in lung cancer screening. // Journal of Medical Physics;Jan-Mar2011, Vol. 36 Issue 1, p51
The article focuses on a randomized controlled lung screening trial conducted by the National Cancer Institute of the National Institute of Health which found that low-dose helical computed tomography (CT) resulted to a reduction in lung cancer mortality.
- Health Affairs article touts lung cancer screening. McCarty, Mark // Medical Device Daily;4/12/2012, Vol. 16 Issue 71, p8
The article focuses on a paper published in the April 2012 issue of "Health Affairs" which said that low-dose spiral computed tomography (CT) is a practical implement for lung cancer screening of patients aged 50-64 who have a history of smoking.
- Study: scans modestly cut lung cancer deaths. Neergaard, Lauran // Tennessee Tribune;11/11/2010, Vol. 21 Issue 45, p6B
The article offers information on the result of a major study, which shows that a special computerized tomography (CT) scans given to heavy smokers can determine lung cancer early.
- CT screens can detect early lung cancer. Hensley, Scott // Modern Healthcare;12/06/99, Vol. 29 Issue 49, p36
Reveals that evidence is growing that computed tomography (CT) can detect early lung cancer in patients at high risk for the disease. Significance of CT detection; Details on the use of CT on patients.
- Patients at highest risk for lung cancer benefited most from low-dose CT screening. // Hem/Onc Today;8/25/2013, Vol. 14 Issue 16, p52
The article reports on the results of a study which investigates the association of low-dose computed tomography (CT) screening and the decrease in mortality among patients with lung cancer compared with chest radiography.
- Locally developed lung cancer classification tool. // British Columbia Medical Journal;Oct2013, Vol. 55 Issue 8, p365
The article focuses on a clinical risk calculator software developed through a study led by the Terry Fox Research Institute (TFRI) which can accurately classify the benign or malignant lesions on an initial lung computed tomography (CT) scan among people who are at high risk for lung cancer.
- Abstracts. Smith, Jeanette M.; Cole, Thomas B. // JAMA: Journal of the American Medical Association;10/25/95, Vol. 274 Issue 16, p1254g
Presents an abstract of the research `Detection of Primary and Recurrent Lung Cancer by Means of F-18 Fluorodeoxyglucose Positron Emission Tomography (FDG PET),' by Francis G. Duhaylongsod et al published in a 1995 issue of the `Journal of Thoracic & Cardiovascular Surgery.'
- PET-CT staging spared NSCLC patients from unnecessary surgery. Adams, Stacey L.; Harris, Jason; Haigh, Christen // Hem/Onc Today;8/25/2009, Vol. 10 Issue 16, p24
The article deals with a study which examined the accuracy of positron emission tomography-computed tomography (PET-CT) in identifying patients with mediastinal and extrathoracic non-small cell lung carcinoma.
- Low-Dose Computed Tomography Screening for Lung Cancer. Soylemez Wiener, Renda // Annals of Internal Medicine;3/17/2015, Vol. 162 Issue 6, p460
The article discusses a study on computed tomography (LDCT) screening for lung cancer and mentions topics including persons living in rural communities having high-risk for lung cancer, recommendation for shared decision making for LDCT screening, and need to maintain a registry of persons.


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I picked out some jaw dropping, elegant and affordable party dresses for this Holiday Season. Holiday dressing is one occasion where I have to spend a ridiculous amount of time finding a dress that I like as well as within my budget – not expensive because I never wear the same party dress more than twice! It also has to be versatile enough to be worn to all occasions such as work functions or weddings, so anything that is too sexy, over the top or bridal are out. I absolutely love the ones I picked and wish I can buy them all! Can you guess which one I bought in the end…answer is below!
1. MAJE – A perfect lady-like midnight blue sequins mini dress with a velvet bow waistband. It's refined, polished and still make you shine.
2. Needle & Thread – Another stunning sequins dress with crystal embroidery (all hand made) in a delicate tulle. It looks very expensive but amazingly affordable.
3. Alice + Olivia – An uber luxe and glamorous dress that is currently at 70% off. The zigzag patterns give an illusion of longer and slimmer silhouette.
4. Whistles – A break from the usual dark colored dresses. Love the pastel color and the modern silhouette. A very fresh and effortless take on party dresses.
5. Alice + Olivia – I own several dresses from Alice + Olivia in the past so I know how beautiful and delicate their chiffon silk dresses look in real life. This navy blue silk dress with embellished jewel neckline in a classic Grecian style is a winner for me. I ordered it immediately as soon as I saw it on sale at SAKS!
6. Zimmerman – The queen of romantic silky drape dresses from Australia! This is one of their best sellers and has been seen on countless celebs. Also available in maxi length.
7. Needle & Thread – This beautiful blue sequins dress in baroque motifs reminds me of my dream Dolce & Gabanna dresses inspired by Italian heritage. A great bargain as it's currently at 40% off at Nordstrom.


text: Arstechnica.com VR goggles and giant touchscreen tables: How Audi explains new car technology Although we usually cover our own travel costs, in this case that was not an option; flights and accommodation on this trip to Munich was paid for by Audi. reader comments 0 Share this story MUNICH, GERMANY—The transformation of our cars over the past few years has been rapid. They used to be autonomous vehicles—in the truest sense—unconnected to the... #virtual #cars #audi Tweet Source: arstechnica.com Read More


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Russia on Saturday urged its Middle East ally Syria to accelerate its political reforms after more than 80 people were reported killed in one of the bloodiest days of a month-long pro-democracy uprising.
The Russian foreign ministry said in a statement that Moscow was "concerned by the heightening of tensions and signs of a confrontation that is leading to the suffering of innocent people."
"We are firmly convinced that only constructive dialogue and accelerated broad-scale political, social and economic reforms outlined by the Syrian leadership can achieving stable and democratic development," the statement said.
Russia has retained close ties with Syria since the Soviet era and is currently supplying the country with advanced missiles and other arms.
Syrian forces killed more than 80 people on Friday in one of the bloodiest days of protests since unprecedented pro-democracy demonstrations erupted on March 15, rights groups said.


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Venturing Rank
Posted 19 September 2014 - 03:39 PM
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Posted 19 September 2014 - 05:57 PM
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Posted 23 September 2014 - 05:18 PM
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Posted 24 September 2014 - 08:21 AM
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Posted 24 September 2014 - 09:23 AM
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Posted 24 September 2014 - 09:56 AM
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Posted 24 September 2014 - 11:19 AM
The changes in the Venturing in the long run can only hurt the program, because National still has not figured out how to deliver an effective and exciting program for high school age youth. Working with Venturing for the past 15 years and maintaining a crew of now 100 members the Venturing leaders in our council both adult and youth HAVE figured out what you need to do and how to do it the right way. All of the crews have members from adjoining councils whose Venturing crews are disappearing faster than their boy scout troops. Venturing is NOT about rank or how many badges you earn and never has been
I agree that "Venturing is NOT about rank or how many badges you earn and never has been", but will point out that neither is Boy Scouts.
The biggest problem I see with crews, even those touted as being "successful crews", is that they are simply adventure clubs, and have lost all sense of the purposes goals of the program. Fun adventures are a tool used to create an environment where the programs goals can be accomplished.
[h=2]Goals[/h] Young adults involved in Venturing will:
- Learn to make ethical choices over their lifetimes by instilling the values in the Venturing Oath and Code.
- Experience a program that is fun and full of challenge and adventure.
- Become a skilled training and program resource for Cub Scouts, Boy Scouts, and other groups.
- Acquire skills in the areas of high adventure, sports, arts and hobbies, religious life, or Sea Scouting.
- Experience positive leadership from adult and youth leaders and be given opportunities to take on leadership roles.
- Have a chance to learn and grow in a supportive, caring, and fun environment
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Posted 24 September 2014 - 12:33 PM
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Posted 25 September 2014 - 03:36 PM
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Posted 25 September 2014 - 09:53 PM
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Posted 26 September 2014 - 08:43 AM
Officially Venturing does not have 'leaders' it has Advisors. The uniform is not require except when attending specific events and they are not ranks, they are still advancements.
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Posted 26 September 2014 - 08:48 AM
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Posted 26 September 2014 - 09:31 AM
I ment to say... Recognition Awards (not rank)
Freudian slip or autocorrect?
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Posted 26 September 2014 - 10:11 AM
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Posted 01 October 2014 - 10:15 AM
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Posted 20 November 2014 - 10:05 PM
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Posted 23 November 2014 - 12:09 PM
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Posted 23 November 2014 - 01:14 PM
Of course, Sea Scouts have a rank system in addition to venturing awards and recognition. Those ranks have very specific meaning. (Just as you wouldn't trust young gangs of boys to be lead by less than first class scouts on their independent outings, you would prefer to not turn your boat over to a less-than-Able seamen.) They also have a collection of recognitions (http://www.seascout....uth/recognition) than include the venturing recognition.
I could imagine a specialty crew (be it in SCUBA or LARP) might have it's own set of "ranks" that would identify a person as qualified to independently operate and lead missions in their specialty.
But, there is no reason to think that a bronze-awarded venturer, even one who happens to be in an outdoor-oriented crew, would have any outdoor skills.
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Welcome to Presentation!
International students at Presentation College excel in the classroom while adding to the college's lively global community. At PC, you will benefit from our small class sizes, hands-on approach, and expert faculty. And, as one of the nation's best small college towns, you will live and learn in a safe and secure environment.
1. Submit the application. APPLY NOW!
2. Submit official academic records from all secondary schools as well as official results from any leaving certificates or university entrance exams taken. Official transcripts from all international secondary and post-secondary institutions must be evaluated by one the below evaluators.
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3. Before your official acceptance for admission. It is your responsibility to complete and pay for the application process. All application materials are property of Presentation College and will not be returned to the applicant, nor shared with another individual, institution, or organization under any circumstances.
4. Submit proof of English proficiency.
- For international students whose native language is not English, you must verify English proficiency by:
- Taking the Test of English as a Foreign Language (TOEFL). Submit the official TOEFL examination scores to Presentation College (School Code 6582). You must score at least 500 (paper-based), 173 (computer-based) or 65 (internet-based).
5. Providing documentation of English as a Second Language proficiency at a college level curriculum—OFFICIAL transcript required.
- Showing successful coursework in English at a high school or institution of higher education in the U.S.—OFFICIAL transcript required.
6. For students whose native language is English, either the American College Test (ACT) or the Scholastic Aptitude Test (SAT) examination is required. Acceptable scores are 18 composite for the ACT or 940 (critical reading plus math) for the SAT.
- As proof of financial support, we require the Presentation College Declaration of Finances form be completed in full and mailed with appropriate documentation to PC Admissions.
7. The Presentation College Declaration of Finances Form provides important needed to prepare the i-20 document for your student visa.
Once all the necessary documents outlined above have been received, the applicant will be reviewed for admission to Presentation College. If accepted, PC will issue a letter of acceptance. To receive an i-20 from PC, you must now complete the following:
Submit the International Student Transfer Form to have your current visa status verified by your current school.
Once submitted, an i-20 will be issued by Presentation College.
NOTE: Tuition must be paid in full each semester before classes start.
I-20 Form
Included in this package is your I-20 form. Please be aware that if any changes are necessary on the I-20, you must return ALL pages of the ORIGINAL I-20 before we will issue you a new one. You must also return all pages of the original I-20 if: 1) You are unable to obtain a visa, and 2) You obtained the visa, but need to request a deferral of your admission to a later semester. All names must match on your legal documents, including the I-20, visa, and passport. You will not be allowed to enter the US more than 30 days prior to the starting date on the I-20 form.
Tuition and fees may increase each year, so the amount indicated on the I-20 form may change without notification and the amount will increase each year. The estimate for tuition and fees on this I-20 is based on the 2016-2017 academic year.
Please note that as of September 1, 2004, you are required to pay a fee for the SEVIS program before you apply for a visa. As of October 27, 2008, that fee is $200. This fee is payable to the US government, NOT our college.
Instructions are available at Department of Homeland Security.
Immunizations and Health Insurance
IMMUNIZATIONS ARE MANDATORY! You are REQUIRED to have two (2) MMR (measles, mumps, & rubella) immunizations in order to be a student at Presentation College. This is mandated by South Dakota state law. There are no exceptions to this requirement. If you are not in compliance, you may be required to withdraw from the College. Two rubella or two rubeola immunizations are not a substitute for the MMR.
The charge for EACH immunization will be approximately $60-70. The requirement that you have two shots means that you will pay $120-140 for your immunizations. These immunizations must have at least 30 days between the first and second injections. For example, if you have the first injection on August 1, you must wait until AFTER August 31 to have the second injection. Please keep this in mind as you prepare to travel to the USA. International students may also be required to take a TB skin test when they arrive.
If you have any questions, you may contact the following:
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TQM campaign plane rotary screen
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Xinfeng grain and oil machinery co., LTD is a company specializing in the production of grain and oil machinery and equipment, scientific research, manufacturing, sales for the integration of large-scale private enterprises, the company with the mechanical design and research institute of henan province, henan university of technology (the former college of food) university-enterprise cooperation, carried out for a long time in oil machinery, preparing protein, lecithin extraction and other aspects of the research and development and application of new technology.
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|17 May 2012
Cataloguing A Movie
As said in the title, I was in the process of cataloging a movie (Police Court), which I downloaded from Archivie.org:
Police_Court : I.E. Chadwick Productions, Directed by Luis King : Free Download & Streaming : Internet Archive
And it was going routinely, until I noticed that the opening credits said that this was copyrighted in 1951 by Albert Finney Productions, which is odd, because my source, iMDB and everything I Googled said that it was released 2-20-1932. Normally, I don't pay much attention to such discrepancies, but this one is quite large, and I tend to believe the film credits more than other sources, especially when it appears that it hasn't been tampered with.
Another difference is that the film list it as a Albert Finney production, whereas other sources list I.E. Chadwick. Chadwick is listed in the credits, but with no identification of his part in the film.
Where would I check for authoritative info to confirm the right date, or to explain the difference?
|My System Specs
|17 May 2012
Microsoft Windows 7 Home Premium 64-bit 7600
edward finney not albert. albert finney was born in 1936.
its possible that edward finney purchased the copyright for the movie at a later date.
|My System Specs
|17 May 2012
Thanks, I sometimes get things turned around, but that still doesn't solve the basic question.
|My System Specs
|22 May 2012
Here is another one just like the first. Same release date, copyright date, even the same producer:
Girl From Calgary : Free Download & Streaming : Internet Archive
How can the release date be 19 years after the copyright date shown in the opening credits?
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Well lets see who has seen the best movie on the, forum ill start with convoy. http://www.youtube.com/watch?v=JuyLTDAC7fE
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2001 HELICOPTER w MOTORCYCLE & CRUISER HESS Toy MIB
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2001 HELICOPTER w MOTORCYCLE & CRUISER HESS Toy MIB
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All LED Light Vest products ship from Grand Rapids, Michigan, USA
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- Can I run ImTranslator with a hotkey?
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- How many voices do you support?
- I cannot play the voice in the translation window, what do I do?
- I want to remove the Pop-up Bubble button when I select the text.
FAQ: ImTranslator for Firefox
gives answers to many questions related to technical, language and functionality issues to make your translation work more user-friendly.
- What is the difference between ImTranslator application and Translator application?
- Can I customize ImTranslator Toolbar button to run different applications?
- Can I customize the context menu to remove some of the items?
- Can I change the Language Interface of ImTranslator to see it on my language?
- I cannot play the voice in ImTranslator. What should I do?
FAQ: ImTranslator for Opera
gives answers to many questions related to technical or functionality issues. Make your online translation work easy and enjoyable.


text: I am starting to plan our trip to WDW and this time we plan on going to sea world and universal. I am thinking that we would maybe spend the rest of our travel day at sea world, and wondering if that is unrealistic. I have a 6 DD, and a 11 DS. We also have 2 days planned for universal, then 5 at WDW. Any thoughts?


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We finally have it…. sort of. After months of not committing to a timetable for a return for point guard Reggie Jackson, Detroit Pistons coach Stan Van Gundy still hasn't. However, Van Gundy did add a bit of clarity by saying that Jackson could be ready to go as early as the first week of December.
While nothing was firm or locked in about what Van Gundy said, it gives relief to Pistons fans to know that there is at least a light at the end of the Reggie Jackson injury tunnel.
Jackson has missed the entirety of the young NBA season due to a platelet-rich plasma injection to Jackson's left knee.
The Pistons have a four game road trip next week, and that's when Van Gundy says Jackson could possibly lace them up.
"Probably after the road trip, probably early December some time," Van Gundy said. "He is starting to do some stuff. He still hasn't done any 5-on-5. He did some 3-on-3 live (during morning shoot-around), a little of it full court.
"He looks good in what he's doing, but he's got to get more comfortable and he's also gotta get his conditioning back. I think that hopefully Monday, the next chance that we get to practice, he'll be able to do some 5-on-5 stuff. We'll see how it goes from there."
The Pistons are 7-9 through 16 games without Jackson, and have been inconsistent on both ends of the floor. Without Jackson, the team has yet to find a reliable go-to scorer late in games, which has resulted in a handful of close losses.
Jackson averaged 19 points and six rebounds last season, his first full season as a starter. He was expected to make a big jump this season until knee problems set him back. While the exact date of Jackson's return is still unknown, there's no doubt that it isn't enough.


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How to get Thicker and Fuller Hair
Hair fall and hair thinning have been two of the main problems women have encountered for years. There are several factors why this happens — aging, nutrition, heredity, etc. Aesthetically, hair is essential and you might even say that it's a woman's asset so it's true when we say that nobody really wants a head with sparse, thin and almost lifeless hair.
A lot of girls and women have been asking the age old questions: "How do I get thicker hair? How can I help my hair grow out thick?" We have the answers to these questions with different hair care approaches but before we go to that, we need to know what's happening beneath the surface.
Some causes of hair thinning include a poor diet, stress, side effects of medication and etc. but the most common cause of thinning hair in women is hormonal imbalance or low progesterone levels. This occurs with women who are at their menopausal ages — sounds inevitable! Yikes! But with proper care (and or medication), it's possible to restore your hair to its fullness and former glory.
Let's take the natural approach first. While medication can definitely do its part in making your hair grow thicker, it's not the only solution available. Here are a few tips that you could try without getting into medication:
1. Apply a protein conditioner to your hair once or twice a week. The protein allows your hair to look thicker because it expands the hair's diameter. This will also strengthen your hair and prevent breakage.
2. Be gentle. Avoid heating and too much styling for the mean time. Choose to air dry your hair instead of blow-drying or ironing it. Be careful and gentle when towel drying and brushing your hair.
3. Prevention is better than cure. If you find that your hair is not thinning out yet, it's better to start preventing it from happening. Eat right, drinks a lot of water, use natural hair care products, and relax when you feel stressed.
4. Use Panthenol containing conditioners. Panthenol targets the hair root and hair shaft, helping hair grow thicker.
5. Use a wide-tooth comb instead of the one with closely set teeth. This prevents further damage and breakage.
Now, let's move on to the medication (or supplements). Like with any other medication out there, it's always important for you to consult a physician so you can see what medication is really right for you. Here are some that are commonly used (again, consulting your physician first):
1. Biotin — take Biotin supplements because one of the known benefits of this is stimulating healthy hair to grow out.
2. Minoxidil — this is actually an antihypertensive drug which promotes hair regrowth. Taking this medication will also slow down the hair loss process.
3. B-complex supplements — a lack of vitamin B could be one of the reasons why your hair is thinning.
There are several treatments out there for thinning hair. We recommend that you take the natural approach of course and remember that prevention is always better than cure, keep up the healthy habits.


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Red Hat Bugzilla – Bug 895245
Port gpodder's use of PIL to support Pillow for F19
Last modified: 2013-10-18 13:42:30 EDT
Created attachment 678450 [details]
Patch to use the form of import of PIL that is pillow compatible
Fedora 19 is going to stop shipping python-imaging (PIL) and start shipping python-pillow instead. Rationale can be found on the feature page: https://fedoraproject.org/wiki/Features/Pillow . pillow should be compatible with PIL at the code level but the import statement changes slightly.
PIL supports both of these:
import Image
from PIL import Image
Pillow only supports the latter form.
I grepped through the gpodder source and found some occurrences of "import Image". I'll attach a patch that updates these to the new form of import.
If I don't hear anything back from you, I'll go ahead and use provenpackager powers to apply this patch to the RawHide package next week. I'll leave sending the patch to upstream up to you, though.
I'm not the primary maintainer but I think the patch seems fine and you're welcome to apply it. Upstream is mostly concentrating on gPodder 3.x and I would need to check if a similar patch is needed there.
Thanks! Built a new gpodder in rawhide with the patch. Do you want this bug left open until you look at whether upstream needs something for gPodder 3.x?
This bug appears to have been reported against 'rawhide' during the Fedora 19 development cycle.
Changing version to '19'.
(As we did not run this process for some time, it could affect also pre-Fedora 19 development
cycle bugs. We are very sorry. It will help us with cleanup during Fedora 19 End Of Life. Thank you.)
More information and reason for this action is here:
Nothing imports Image in gPodder 3.x so this bug can be closed. Thanks Toshio!


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Strong Levels of Concern Elicited by Messages
Recent research conducted under the American Perceptions Initiative found that messages about the possible impacts of the Iran nuclear deal elicited strong concern among the voters sampled, with 8 in 10 Americans saying they felt concern about each (80%-84% somewhat/extremely concerned). In fact, about half felt extremely concerned (43%-57%).
Tie Messages to Existing Concerns
While all messages were strong, those linking the deal to existing concerns, such as a nuclearized Middle East or terrorism, elicited more concern. Specifically, communications that tie the lifting of sanctions to a possible increase in funding for terrorist groups elicit stronger concern than other messages.
Communications More Likely to Raise Concern Among Those Who Are "Informed"
Notably, a message highlighting the weak nature of the deal compared to initial hopes was more likely to elicit concern from those who are familiar with the agreement than those who are unfamiliar with it, indicating its usefulness with a more informed audience.
- The administration first sought to dismantle Iran's nuclear facilities, but the only thing this treaty dismantles is the sanctions and inspections that have kept Iran's nuclear proliferation in check—85% vs. 79% concerned
Messaging Tip
- Tie to existing concerns—Messages linking to terrorism and a nuclearized Middle East highlighted concerns most effectively.
Source: Online survey using a national representative sample of 865 U.S. voters conducted July 13, 2015 with a margin of error of ±3.3%.


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Looking for a vacation rental in Doncaster East? Tripping.com has 32 rental homes available in Doncaster East. Potential renters will find 0 studios, 18 1-bedroom, 4 2-bedroom and 10 rentals with 3 or more bedrooms ranging from $30 a night to $156 a night. Many of these properties are instantly bookable.
The average price of a nightly rental in Doncaster East is $121 while the average price of a weekly rental is $607. For those looking for more than a short term rental such as corporate rentals, extended stays or long term rentals, the average monthly price of a Doncaster East home is $2859.
Wondering if you can bring your favorite dog or cat with you? We have 3 pet friendly vacation rentals available for you. In addition to accommodating pets, Doncaster East rentals offer a variety of amenities. In particular, 27 rentals have internet and wifi, 18 have TV and/or cable and 2 have a pool or hot tub.Search properties from 6 rental sites in Doncaster East where the top providers in that area are Booking.com, HomeAway, and Agoda. There are 8 Booking.com rentals, 7 HomeAway short term rentals and 7 Agoda vacation rentals.


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- National Museum of American History
- National Archives
- Monuments and Memorials Tour
Day 2 You'll See:
- Library of Congress
- Capitol Hill Tour
- Newseum
- White House Photo Opp
This whirlwind 2 day D.C. educational extravaganza gets you around to some of the most popular highlights of our nation's capitol. Explore the Smithsonian's National Museum of American History, then head over to the National Archives for a peek at our Constitution and the Declaration of Independence. You'll visit the Library of Congress, Capitol Hill and the incredible 6-story Newseum, then head to the White House for a most memorable photo opportunity!
National Museum of American History
The Smithsonian's American Museum of Natural History is truly a behemoth; be prepared for lots of walking! Visit a lush butterfly rainforest, drift into the Dark Universe and thrill to a Great White Shark experience, IMAX-style. A hearty hike through the Hall of North American Forests introduces visitors to the ecology and variety of the woodlands of North America—from the Northern Spruce and Fir forests of Ontario to a giant cactus "forest" in Arizona. Wander the Biodiversity and Environmental Halls and marvel at their vivid and inspiring vision of the spectacular beauty and abundance of life on planet Earth. The Bernard Family Hall of North American Mammals offers a stunning snapshot of North America's rich environmental heritage, while the Hall of Small Mammals depicts a variety of animals in detailed dioramas of their natural habitats. Every year, the Museum's beloved Origami holiday tree delights guests from all walks. Hear the story of Lonesome George, excavate the endless wonders of Fossil Halls, shimmy beneath a 21,000 pound model of a Blue Whale in the Milstein Hall of Ocean Life and so much more!
National Archives
The National Archives and Records Administration stores and provides public access to the original documents that set up the American government as a democracy in 1774; additionally, the records of the nation's civil, military and diplomatic activities are held here for present and future generations. Your student group will be transported on a fascinating journey through time, with an opportunity to view the United States Government's Charters of Freedom, the U.S. Constitution, the Bill of Rights, and the Declaration of Independence. This fantastic learning experience should own a slot on every D.C. educational trip – don't forget a stop by the gift shop for that perfect memento of your visit!
Monuments and Memorials Tour
This brisk scenic walkabout is an absolute MUST on every student trip to Washington, D.C. and gets you and your group around to all of its exciting monuments and memorials - each truly unique and important in its own right. Your invigorating excursion begins at the White House and continues through the National Mall, along the Reflecting Pool and around the Tidal Basin, winding to a neat finish at the U.S. Capitol Building and Supreme Court.
Library of Congress
Rise and shine, well-rested itinerants! Your 2nd day in D.C. has you heading out to the magnificent Library of Congress right after breakfast. It's the nation's oldest federal cultural institution and the world's largest library, containing more than 128 million items including books, manuscripts, films, photographs, sheet music and maps. As part of the legislative branch of government, the Library houses several internal divisions, including the Office of the Librarian, U.S. Copyright Office, Law Library of Congress, Library Services, and the Office of Strategic Initiatives. Visitors flock year-round to partake of its wonderful exhibitions, interactive displays, concerts, films, lectures and special events.
Capitol Hill Tour
No educational tour of Washington, D.C. would be complete without a visit to the seat of our legislative and judicial branches. You and your students will enjoy a short, informative video before moving on to explore the breathtakingly magnificent Capitol and Supreme Court Buildings, the Jefferson Building at the Library of Congress and the stunning U.S. Botanic Garden/Conservatory.
After touring Capitol Hill, you and your young charges zip over to the Newseum - a seven-level, high-tech interactive museum tracing the history of news reporting from the 16th century to the present day. Located between the White House and the U.S. Capitol, the Newseum houses 15 theaters, 14 major galleries, two state-of-the-art broadcast studios and a 4-D time-travel experience in its 250,000 square feet of exhibit space, with its fascinating and comprehensive galleries exploring news history, photojournalism, world news and media coverage of major historical events. Miss the morning paper? Not to worry! Each day, the Newseum serves up the fresh front pages of more than 450 news publications from around the world.
White House Photo Opportunity
Your group will enjoy a pre-arranged White House Photo Opportunity with the most famous residence in our country in the background. What a fantastic way to commemorate your trip to Washington, D.C.!


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Keep your shoes organized with this stackable Seville Classics 3-Tier Mesh Utility Shoe Rack in light gray. It features removable mesh panels for adding and connecting multiple shoe racks together. Folds flat for easy storage and setup is a snap. No tools required.
- Units are stackable
- Light gray finish
- Folds flat for easy storage
- No tools required; simple setup


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We recommend upgrading to the latest Internet Explorer, Google Chrome, or Firefox.
If you are using IE 9 or later, make sure you turn off "Compatibility View".
Handpicked brands for you
Not enough storage in your boat to lift all the gear? Choose an all-in-one board like the Omnia. More possibilities, more fun. #watersports #waterfun #allinone #favorite #family


text:
We recommend upgrading to the latest Internet Explorer, Google Chrome, or Firefox.
If you are using IE 9 or later, make sure you turn off "Compatibility View".
Handpicked brands for you
Our friends at @redfangband are about to head off on tour across the US. Keep an eye out for these new hats at each tour stop and stay tuned for a drop on our website, coming soon... #redfang #tourmerch


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Flash & Nu Androids present
Eelke Kleijn
645 Florida Ave NW
Washington, DC, 20001
Doors 9:00 PM / Show 10:00 PM (event ends at 3:00 AM)
This event is 21 and over
Watch & Listen
Eelke Kleijn is a rare talent. With work stretching across movie trailer scores, deep live shows and incredibly well formed production, he crosses a boundary from electronic producer and in to a true modern day composer. With peers and tastemakers standing up for this unmistakable imagination, the Rotterdam based music maker's potential has no bounds.
With 2 artist albums delivered, an array of originals and first class remixes what he has achieved thus far would be any DJ's reverie. Ultra to EMI, Global Underground to 3 Beat Records and Spinnin' to Sudbeat have seen the young Dutchman's vision in productions become world heard, not to mention his very own label, Outside The Box Music. With each record distinct but all out floor fillers, they have been pumped out in his epic sets from Argentina to Netherlands and Australia to the UK.
A BBC Radio 1 'Next Hype' act for 'Stand Up' and Hollywood 'soundtracker' for Parker, Wrath Of The Titans, This Means War and not least Ron Howard's Rush trailers, his career is in a constant accelerating push to the top. Tipped by Fatboy Slim, Pete Tong, Loco Dice, Rudimental and more we all lie in wait for his next move, and with no project too big and nothing to faze him, we have all only seen the half of Eelke Kleijn's Midas touch.
Nu Androids is a community of music enthusiasts. We invite artists from all around the world to come perform at our weekly events. Come join our family, we're all a little weird.
Connect with us:
Twitter: @nuandroidsmusic
Instagram: @nuandroidsmusic
Soundcloud: www.soundcloud.com/nuandroidsmusic
Who's Going
Upcoming Events
Fri, November 24
Jan Krueger - N/UM
Sat, November 25
Soul Clap
Wed, November 29
Juan Maclean [DJ Set], Marcus Mar [DJ Set]
Fri, December 1
Eli & Fur
Sat, December 2
Chris Carrier (Adult Only)


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Results 1 to 2 of 2
10-02-03, 11:23 #1Registered User
- Join Date
- Oct 2003
- Posts
- 2
Unanswered: Newline in field causing SQL Loader Problem
I am using SQL Loader (both from inside Toad, and using Oralce SQLloader from command line) to import flat files into an Oracle DB.
The record separator is a newline character.
The pipe | is the field separator.
Some of the records have a newline character in the middle of the field.
This is causing problems with importing the data, as the record either is only imported partially, or data is put into incorrect fields.
Is there a way in a SQL loader script to address this issue without changing the structure of the import file (I get it from someone else, and will have difficulty changing the structure).
Also, in the future, we will be using Informatica to import this same data.
Does anyone know if have newline as the record separator and having newline characters in fields will cause similiar problems with Informatica?
10-02-03, 13:49 #2Registered User
- Join Date
- Aug 2003
- Location
- West
- Posts
- 101
Only I should think, if the records are fixed length; otherwise - how would you ever know when a newline character is part of a field or not? I know of no logical way to test through dts. Perhaps you can write a script to count pipes.


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Till now, Madea has messed up everything that she puts her hand in and now she has got a job. To see how she pulls off this time, come and watch Tyler Perrys Madea Gets a Job Detroit. She does not intend to get clumsy but she can't help causing trouble. After the success of her play turned movies, Tyler Perry has come up with another stage play where Perry turned into Madea and has embarked on another adventure filled with hilarious moments for the audience. Perry has taken up to entertain people with his immensely creative and comic productions and has gathered a huge fan following who cannot seem to decide whether they should adore Perry for his productions or Madea for her amazing acting.
Buy - Tickets
Q:How much are the handling charges that i will have to pay on madea get a job detroit et tickets?
A:You can get your required details about the handling charges from the checkout page of Tyler Perrys Madea Gets A Job Detroit Tickets.
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text:
Today was one of those days where I had way too much to do. I had to wash and blow out my own hair (hence the fro-like texture, I usually go to my Dominican hairstylist), then run to an audition in West LA (the reason I needed to blow out my hair), then run back home to eat, and for a shoot (pictured below), and to walk my dog. Then emails, then back to the West Side for a friend's screening party, then back to Hollywood for another friend's show! I somehow got it all done, but now it's after midnight and I'm exhausted and still posting this rather than going to bed…why?! Because I love being busy and sometimes when I have crazy days like today my body and mind just can't stop. But it's not good, my friend, not good! I'm usually pretty great at scheduling my day to avoid such madness but today I was overbooked. Luckily tomorrow there is only one thing on the schedule. Happy Friday! Ok, I'm going to bed!
In this look: American Apparel bodysuit, Madewell jeans, Vintage Cowboy boots, Melody Ehsani watch ring and my 8th grade confirmation gift, a "Grasie" ring from my Titi.
Photos by Sylvia G Photography


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Welcome to WebmasterWorld Guest from 220.127.116.11
Of the 1,930 new domain names submitted to ICANN recently, who had the most applications?
Was it Amazon with 76? Not even close. How about Google with 101? Nope.
Actually, that'd be Donuts with 307 submissions from .app to .sucks. The group beat out behemoth Google for most submissions by more than a factor of three.
They've staked their claim for domains such as .basketball, .shop, .computer and .film.
"We're very happy chaps at the moment," Donuts co-founder Dan Schindler told The Times in an interview from the company's Los Angeles office.
[edited by: Webwork at 3:26 pm (utc) on Jun 22, 2012]


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Pha Sawoei
The type of search By District | By Place
Map Have Map No Map
Kalasin attractions
Attractions in Thailand
Operating day: Daily
Operating time: 08.30 - 16.30
Pha Sawoei It is located on the Phu Phan mountain range in Ban Kaeng Ka-am, Tambon Pha Sawoei. It is 17 kilometres from Somdet district, and about 58 kilometres from Kalasin along the Somdet – Sakon Nakhon route on Highway No. 213, at Km. 101 - 102. Pha Sawoei was formerly called "Pha Rang Raeng".
In 1954, Their Majesties the King and the Queen visited the cliff and had lunch here, so the place's name was changed to 'Pha Sawoei' (Sawoei is a royal term for eating). As it is located in the deep valley with a high cliff, the locals also called it 'Heo Ham Hot'. It is a good sightseeing and relaxing spot for visitors.
Pha Sawoei Map
Category: ●Nature and Wildlife
Group: ●Mountain (Doi)
Tag: ●Pha Sawoei
Last Update: 2 MonthAgo
|Keyword (Advance)
Facebook Fanpage


text:
Spill dumps fuel into creek: 6,000 gallons of petroleum leak out
Scott Carney from the Tucker office of HEPACO, a Charlotte, N.C.-based environmental remediation company, vacuums spilled fuel products Sunday afternoon from a creek along Mitchell Bridge Road. The source of the fuel products was David Oil Co., Inc. on Jefferson Road near the creek's origin.
Dot Paul/Staff
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|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|Mark <static.void....@gmail.com>
|Re: Pig output to Cassandra
|Fri, 11 Mar 2011 05:43:00 GMT
Sweet! This is exactly what I was looking for and it looks like it was just resolved. Are there any working examples or documentation on this feature? Thanks On 3/10/11 8:57 PM, Matt Kennedy wrote: > On its way... https://issues.apache.org/jira/browse/CASSANDRA-1828 > > On Mar 10, 2011, at 11:17 PM, Mark wrote: > >> I thought I read somewhere that Pig has an output format that can write to Cassandra but I am unable to find any documentation on this. Is this possible and if so can someone please point me in the right direction. Thanks
|View raw message


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I'm by no means an expert but maybe I can give you some advise. When I was diagnosed about 3 months ago, I took a test at my counselors office. I don't remember the name of it. Any psychiatrist, pscychologist etc, will have this test and rate you based on your answers. I'm glad you are seeing your psychiatrist soon. Make sure to ask him/her what they think. Be very thorough with your answers and give all details. If you have to write them down to remember, do it.
The way I understand bipolar is a dramatic swing from one pole (mania) to the other pole (depression). There is also anxiety invloved. I'm what they call a rapid cycler. I can swing from one end to the other in a matter of hours or days. I can also swing a bit slower, by weeks. I do bizzare things in my manic phases. I'm not a happy manic, I get angry. I tend to spend ALOT of money when I'm in my manic phases. I had to have my sister take my credit cards from me. I'd then come home and open EVERYTHING so I couldn't return it. I get very mouthy with people, don't care who, police, court clerks and judges, even the poor grocery checker. I've come really close to being thrown in jail for my mouth. I develop severe road rage and play chicken with the car I'm mad at. The list goes on and on. When I'm depressed, I stay at home, in my PJ's, wanting to do nothing, go nowhere and just shower and put more jammies on. I won't answer my phone, talk to anybody, and this list goes on too.
We just readjusted my meds again for the third time in about 6 weeks. This round seems to be working better. I can't keep going like this. Money is already tight and I'm making it worse. But looking back on the last 8-9 years, I can see all of these things were there, I just wasn't diagnosed. I just thought I was losing my mind.
If you are bipolar, there is help out there. I've learned that the hard way in the last few months. I'm trying very hard to come to terms with my illness. Some days are good, others are bad. Just take it as it comes.
I hope this helps you a bit. Good Luck!
Twiggy, my name is Beth and I think I may have replied to a post or two of yours in another section of the forum. I too think I may be Bp with anxiety. I am going to the dr. after the new year to have them look into it. I have been questioning this for some time now. I experience phases of extreme high and extreme low for days/weeks at a time accompanied by extreme anxiety. But when I go online and read info on BP, the examples given for each cycle are extreme and anxiety is not a major characteristic (from what I read). I am not that extreme when I am high. I just have alot of engergy and volunteer myself for everything. Some examples are, I have volunteered for puplic fundraisers and projects, trained for Marathons, rearange my whole house in the middle of the night. I just take on everything. I don't understand this because I have constant anxiety, why would I get my self involved in things I know darn well will give me anxiety attacks. I am my own worse enemy. My lows are pretty bad. I don't even want to shower or brush my teeth. I don't pick up the phone or get out of bed. I swing back and forth with the moods, so this is why I though there may be some thing else going on with me. My situation can not just be GAD.
Twiggy, what do you go through?
If anyone as any thoughts to my situation, please share. I could really use someone elses opinion. Thanks.
I just read back what I wrote, and I wrote that my high is not that extreme. Reading my own examples, I realized that it is extreme. I think I was thinking that extreme had to be spending alot of money or I don't really know. Can everyone's mania be different? Are there spefic activities or things a person does during a manic phase?