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Correspondence to: Romain Altwegg, MD, the Oncology and Digestive Endoscopy Department of CRLC Val d'Aurelle, 34000 Montpellier, France. email@example.com
Telephone: +33-608-714230 Fax: +33-467-613729
AIM: To investigate second-line chemotherapy in gemcitabine-pretreated patients with advanced or metastatic pancreatic cancer [(frequency, response, outcome, course of carbohydrate antigen 19-9 (CA 19-9)].
METHODS: This retrospective study included all patients with advanced or metastatic pancreatic cancer (adenocarcinoma or carcinoma) treated with second-line chemotherapy in our center between 2000 and 2008. All patients received first-line chemotherapy with gemcitabine, and prior surgery or radiotherapy was permitted. We analyzed each chemotherapy protocol for second-line treatment, the number of cycles and the type of combination used. The primary endpoint was overall survival. Secondary endpoints included progression-free survival, response rate, grade 3-4 toxicity, dosage modifications and CA 19-9 course.
RESULTS: A total of eighty patients (38%) underwent a second-line therapy among 206 patients who had initially received first-line treatment with a gemcitabine-based regimen. Median number of cycles was 4 (range: 1-12) and the median duration of treatment was 2.6 mo (range: 0.3-7.4). The overall disease control rate was 40.0%. The median overall survival and progression-free survival from the start of second-line therapy were 5.8 (95% CI: 4.1-6.6) and 3.4 mo (95% CI: 2.4-4.2), respectively. Toxicity was generally acceptable. Median overall survival of patients with a CA 19-9 level declining by more than 20% was 10.3 mo (95% CI: 4.5-11.6) vs 5.2 mo (95% CI: 4.0-6.4) for others (P = 0.008).
CONCLUSION: A large proportion of patients could benefit from second-line therapy, and CA 19-9 allows efficient treatment monitoring both in first and second-line chemotherapy.
Pancreatic cancer is the tenth most common cause of cancer in the United States and the fourth leading cause of cancer death, with an estimated 42 000 new cases and 35 000 associated deaths in 2009[1]. In France, over 7200 patients were diagnosed with a pancreatic cancer in 2008, and almost the same number died from their disease[2]. At the time of diagnosis, most of patients present with advanced or metastatic pancreatic cancer, thereby precluding surgical resection[3]. Gemcitabine has been considered as the standard treatment for advanced pancreatic cancer ever since a randomized trial demonstrated significant improvement in survival and clinical benefit over 5-FU[4]. However, its efficacy remains moderate with median overall survival (OS) times ranging from 5 to 8 mo, and one-year survival rates varying between 17% and 25%. Numerous studies have attempted to increase efficacy of chemotherapy by combining gemcitabine with other drugs, but most of the regimens evaluated in phase III trials failed to show any improvement in overall survival[5-18]. Only one randomized trial[6] (n = 569 patients) comparing gemcitabine alone vs gemcitabine combined with erlotinib showed a modest but significant increase in OS in the erlotinib arm (6.2 mo vs 5.9 mo, P = 0.025). Actually, the rate of patients receiving second-line chemotherapy varied from 16% to 57% in the trials evaluating a gemcitabine-based combination therapy[7-18]. This difference can be explained by both the deterioration in performance status after gemcitabine and the absence of recommended standard treatment in second-line[19]. Despite limited clinical data in this situation, a phase II trial comparing oxaliplatin/folinic acid/5-FU (OFF) combination vs best supportive care as second-line treatment in gemcitabine-pretreated patients with advanced pancreatic cancer showed substantial benefit in the chemotherapy arm, with an overall survival prolonged by 2.6 mo (P = 0.008)[20].
Serum carbohydrate antigen 19-9 (CA 19-9), the sialyted Lewis blood group antigen defined by the monoclonal antibody 1116 NS 19-9[21], is the most common tumor marker in Europe and in the United States for patients with pancreatic cancer, both as a prognostic factor and an early marker of response to treatment. To date, the reliability and prognostic value of CA 19-9 levels to monitor first-line chemotherapy of advanced pancreatic cancer patients is well established[3].
In this context, this study aimed to describe the frequency of gemcitabine-pretreated patients with advanced or metastatic pancreatic cancer receiving second-line chemotherapy, their overall survival and progression-free survival. We also investigated response rates, outcome and potential correlations between the level and course of CA 19-9 and survival.
This retrospective study included all adult patients with an advanced or metastatic histologically proven pancreatic cancer (adenocarcinoma or carcinoma) initially treated with gemcitabine in our center between 2000 and 2008. All patients received first-line chemotherapy with gemcitabine at a dose of 1000 mg/m2 once weekly for 7 wk followed by 1 wk of rest; thereafter, gemcitabine was given once weekly for 3 wk followed by 1 wk of rest until progression of disease. Prior surgery or radiotherapy for local disease was permitted. All patients' medical records were registered within a computerized database [following national registry council (CNIL) authorization]. While there was no standard treatment used in second line, the treatment decision regarding a second-line therapy was systematically made by a multidisciplinary oncology committee according to the performance status, age and comorbidities.
We assessed each second-line chemotherapy protocol for the duration, the number of cycles and the type of drug combinations. The primary endpoint was OS. Secondary endpoints included progression-free survival (PFS), response rates, grade 3-4 toxicity, dosage modifications and CA 19-9 course. We stratified overall survival and progression-free survival according to the response to gemcitabine treatment (duration of treatment ≥ or < 4 mo) and the performance status (0-1 vs 2-3). Response rates and disease progression were evaluated after 2 mo of treatment by Response Evaluation Criteria in Solid Tumors[22] and clinical examination. Toxicity was assessed at every visit using the National Cancer Institute Common Toxicity Criteria v.2.0 (CTC AE v2.0). The CA 19-9 levels were determined from serum samples collected at baseline (maximum one month before starting treatment) and at final treatment evaluation. A value of 60 IU/mL was accepted as the upper limit of normal. A reduction in CA 19-9 level was considered as relevant when serum concentrations decreased by more than 20% after the completion of treatment.
In this retrospective study, information relating to identification, treatment, available biological material, surgery, response to therapy and outcome were collected for each patient. The primary objective was to evaluate the efficacy of a variety of second-line regimens in a large series of advanced pancreatic adenocarcinoma after first-line treatment with a gemcitabine-based regimen. Categorical variables were reported by contingency tables. Continuous variables were expressed as medians and ranges. The objective response rate was presented with a 95% CI. Survival rates and median values were estimated according to the Kaplan-Meier method. Patients alive at the tie of analysis were censored at their last follow-up examination. Overall survival duration was measured from the date of first infusion until death from any cause. Progression-free survival duration was calculated from the date of first infusion until the first disease progression. Survival curves were drawn, and the log rank test was performed to assess differences between groups. All reported P values are two-sided. For all statistical tests, differences were considered as significant at the 5% level. Statistical analyses were performed using the STATA 9.0 software.
Baseline characteristics of the study population are detailed in Table Table1.1. Of 206 patients receiving a first-line gemcitabine-based treatment for advanced or metastatic pancreatic cancer, 80 patients (38%) underwent a second-line therapy between January 2000 and May 2008. The median age was 61 years (range 36-81 years), and 38 patients were male (47.5%). The diagnosis of cancer was histologically confirmed in 67 patients (83.8%). Thirty-seven patients had undergone surgery including a pancreatoduodenectomy (n = 25) and palliative operation (n = 12) before first-line chemotherapy. Three other patients had received external radiation therapy. An endoscopic biliary prosthesis had been inserted prior to chemotherapy in eight patients. All patients received first-line chemotherapy with gemcitabine, with a median of 3 cycles (range: 1-12) and a median duration of 3.3 mo. Twenty-nine patients (36.2%) were treated for more than 4 mo. A total of 77 patients (96.3%) had evidence of metastatic disease, for most of them localized in the liver (70.1%). Despite the advanced stage of disease, patients generally showed good performance status before initiating second-line treatment, the WHO PS was of 0-1 in 71 patients (88.7%) and ≥ 2 in nine patients (11.3%).
From the CA 19-9 analyses performed in 64 patients, fifty-seven (89.1%) showed an elevated level, and initial median serum concentration was 741.5 IU/mL (range: 2-2000 IU/mL).
The median number of second-line chemotherapy cycles was 4 (range: 1-12) and the median duration of treatment was 2.6 mo (range: 0.3-7.4).
All treatment regimens are described in Table Table2.2. Different drug combinations were used in second-line. Twenty-three patients (28.8%) received a treatment with cisplatin (cisplatin group), 22 patients (27.5%) with irinotecan (irinotecan group) and 21 patients (26.3%) with oxaliplatin (oxaliplatin group). Fourteen patients (17.5%) were given other treatment, including a single agent for four of them. The duration of treatment did not significantly differ between groups (Table (Table33).
There was no complete response. Six patients (7.5%) achieved a partial response, 26 patients (32.5%) a disease stabilisation, 44 patients (55.0%) experienced disease progression and 4 patients could not be assessed. The overall disease control rate (complete response, plus partial response, plus stable disease) was 40.0% (median follow-up was 6.0 mo).
The median OS from the start of second-line therapy was 5.8 mo (95% CI: 4.1-6.6 mo). The 1-year and 2-year OS rates were 13.6% (95% CI: 6.9-22.7 mo) and 6.1% (95% CI: 2.0-13.5 mo), respectively (Figure (Figure1A).1A). The median PFS from the start of second-line therapy was 3.4 mo (95% CI: 2.4-4.2 mo). The one-year and two-year PFS rates were 6.0% (95% CI: 1.8-13.9 mo) and 4.0% (95% CI: 0.8-11.5 mo), respectively (Figure (Figure1B).1B). There was no significant difference between the four chemotherapy groups for overall disease control rates, overall survival and progression-free survival (P > 0.05) (Table (Table33).
The median OS was 6.3 mo (95% CI: 4.3-7.2 mo) in patients with a performance status of 0-1 (71 patients) vs 1.8 mo (95% CI: 0.3-5.9 mo) in patients with a PS > 1 (9 patients) (P < 0.001). The one-year OS rates were 16.0% and 0%, respectively. The median PFS was 3.4 mo (95% CI: 2.6-4.9 mo) in patients with a performance status of 0-1 vs 2.1 mo (95% CI: 0.5-3.0 mo) in patients with a PS > 1 (P = 0.004). The one-year PFS rates were 7.0% and 0%, respectively.
The median OS times were 7.2 mo (95% CI: 4.5-10.5 mo) in patients treated for more than 4 mo with gemcitabine as first-line therapy (29 patients) and 4.2 mo (95% CI: 3.2-5.9 mo) in those treated less than 4 mo (51 patients) (P = 0.046). The one-year PFS rates were 10.0% and 4.0%, respectively.
Toxicity was generally acceptable. The incidence of severe adverse events (grade 3-4) is reported on Table Table4.4. Twenty-seven patients (33.7%) experienced at least one grade 3-4 toxic event. Neutropenia was the most frequent haematological toxicity, occurring in 14 patients (17.1%). There were 5 chemotherapy-related deaths. Two deaths were attributed to sepsis, and three to a combination of cancer and treatment-related complications. There was no difference in the incidence of toxicity and treatment-related deaths between the four chemotherapy groups (Table (Table55).
Forty-one patients (51.3%) had dosage modifications, including treatment suppression for 7 patients, dose reduction for 17 patients and cycle delay for 33 patients. Dose reductions were caused by haematological (9 patients, 53%) or clinical toxicities (8 patients, 47%) (Table (Table6).6). In thirty-one patients (41.3%), the chemotherapy was discontinued before evaluation because of disease progression (74.2%), toxicity (9.7%) or death (16.1%). There was no significant difference between groups for dose modification and chemotherapy discontinuation before evaluation.
Reduction in CA 19-9 levels during treatment was associated with improved survival. The median OS was significantly higher in patients whose level of CA 19-9 declined by more than 20% when compared to other patients 10.3 mo (95% CI: 4.5-11.6) vs 5.2 mo (95% CI: 4.0-6.4) (P = 0.008) (Figure (Figure2A).2A). In this subgroup of patients, the median PFS was 6.7 mo (95% CI: 3.3-8.8 mo) vs 3.4 mo (95% CI: 2.6-4.2 mo) (P = 0.031) (Figure (Figure2B).2B). All patients who experienced a CA 19-9 reduction > 20% achieved disease control (3 partial responses and 5 cases of stable disease).
If gemcitabine-based chemotherapy is the current standard of care for first-line treatment of advanced pancreatic cancer, there are limited data to support a standard second-line chemotherapy regimen[23]. Indeed, the true survival benefit from first-line therapy is small, and few patients can endure a second line as their performance status deteriorates with disease progression. In our study, the rate of patients treated with second-line chemotherapy was 38.8%, in accordance with most published data regarding gemcitabine-pretreated pancreatic cancer (16%-57%). Median overall survival from the start of second-line setting was 5.8 mo (4.1-6.6 mo), and median progression-free survival was 3.4 mo (2.4-4.2 mo). These results are similar to those obtained in first-line with gemcitabine by Burris et al[4] or Heinemann et al[9]. Moreover, patients with good performance status (0-1) and who had benefited from gemcitabine chemotherapy in first line (duration of treatment ≥ 4 mo) had a significantly greater duration of overall survival than those who had not (6.3 mo vs 1.8 mo, P < 0.001; and 7.2 mo vs 4.2 mo, P = 0.046, respectively). The rate of grade 3-4 toxicity was determined to be 33.7% (27 patients), but there were no unexpected side effects. Consequently, our experience demonstrates that a selected population of patients with good performance status can benefit from second-line chemotherapy after first-line gemcitabine-based treatment, with appreciable overall and progression-free survivals. This retrospective study included a large population, while most of data published over the last ten years involved relatively small samples in monotherapy (from 13 to 52 patients) as well as in bitherapy (from 12 to 46 patients)[24]. The disease control rate was 40%, as described by many authors for both monotherapy and bitherapy regimens, and median overall and progression-free survivals were superior to those reported in monotherapy studies, but were not different from bitherapy[24].
In daily practice, second-line therapies are regularly used in gemcitabine-pretreated patients with pancreatic carcinomas, but the efficacy and benefit in terms of survival or quality of life have never been validated. A randomized phase III trial conducted in second line was presented by Pelzer et al[25]. One hundred and sixty-five gemcitabine-pretreated patients with pancreatic cancer were randomly assigned to receive either FF (5-FU 2 g/m² for 24 h plus folinic acid or leucovorin 200 mg/m² on days 1, 8, 15 and 22) or OFF (FF plus oxaliplatin 85 mg/m² on days 8 and 22). Median overall survival and progression-free survival were significantly improved with OFF protocol (20 wk vs 13 wk, P = 0.014; and 13 wk vs 9 wk, P = 0.012, respectively), with an acceptable tolerance profile. This study illustrated the effectiveness of this protocol which may become the standard second-line therapy. Currently, the National Comprehensive Cancer Center pancreatic cancer guidelines encourage the participation of patients with satisfactory performance status in clinical trials, and recommend the use of oxaliplatin and fluoropyrimidine if enrolment in trials is not possible[26,27]. Finally, the XELOX regimen[28] showed comparable efficacy to FOLFOX (or OFF) regimen, while offering the advantage of oral fluoropyrimidine treatment. Even so, more large randomized controlled trials are required in second line before a new standard of care can be established.
Interestingly, the CA 19-9 measurement was correlated with OS and PFS in our study. Patients whose level of CA 19-9 declined by more than 20% had a significantly greater duration of survival. The prognostic value of CA 19-9 level and course is well established for patients with pancreatic cancer treated with surgery[29-31], radiotherapy and chemoradiotherapy[32,33]. Some studies also correlated the level and the course of CA 19-9 with OS and PFS of pancreatic cancer patients treated with gemcitabine as first-line chemotherapy[3,34-36]. These studies showed improved median OS for patients with a decrease of CA 19-9 > 20% after two months of treatment with gemcitabine. Saad et al[37] reported an increase in the median OS for patients with a reduction of CA 19-9 at any time after treatment. In second-line, only one study demonstrated that a CA 19-9 value > 400 IU/mL was a significant independently negative prognostic factor[38]. To our knowledge, it was the second report which showed a correlation between OS and CA 19-9 course[39], and the first report for PFS and CA 19-9 course in second-line chemotherapy for gemcitabine-pretreated patients with pancreatic cancer.
In summary, treatment of metastatic pancreatic cancer remains a major challenge and requires new chemotherapeutic and targeted agent combination to be compared to gemcitabine in first-line. It should be noted that a new therapeutic alternative could merge in first-line for selected patients according to the recent results obtained in a randomized Phase III study comparing FOLFIRINOX regimen to gemcitabine[40]. A significant longer overall survival, progression-free survival, and higher response rates were obtained with FOLFIRINOX than with gemcitabine alone, associated with manageable toxicities.
The present study focused on second-line therapy in gemcitabine-pretreated patients with advanced pancreatic cancer. From our experience, second-line chemotherapy is a valuable treatment option after progression on gemcitabine-based regimen, because 30% to 40% of patients could benefit from this therapy, especially those with good performance status (1-2) and who gained benefit from first-line therapy. Further randomized clinical trials are necessary to provide a standard treatment in this situation. Additionally, measurement of the CA 19-9 level was confirmed to be an efficient marker for treatment monitoring in first-line as well as in second-line treatment.
Most of patients have advanced or metastatic pancreatic cancer at the time of diagnosis, and cannot benefit from surgery. Gemcitabine-based chemotherapy is the standard treatment in first-line, but there are limited data to support standard second-line chemotherapy.
In practice, second-line therapies are regularly used in gemcitabine-pretreated pancreatic carcinomas, but the efficacy and benefit in terms of survival or quality of life have never been validated. Most of published studies in second line involved small samples, in monotherapy as well as in bitherapy.
In our study, the rate of patients treated with second-line chemotherapy was 38.8%, and median overall and progression-free survivals from the start of second-line were similar to those obtained in first-line with gemcitabine. Carbohydrate antigen 19-9 (CA 19-9) course was correlated with prolonged overall and progression-free survival.
Second-line chemotherapy is a valuable treatment option after progression on gemcitabine-based regimen, because 30% to 40% of patients could benefit from this therapy. Measurement of the CA 19-9 level was confirmed to be an efficient marker for treatment monitoring, in first-line as well as in second-line treatment.
The study is very interesting because there is no consensus about second-line therapy after disease progression while patients are receiving gemcitabine. The paper is well written. However, the authors should revise several points in the entire text.
Peer reviewer: Dr. Gerardo Rosati, Medical Oncology Unit, S. Carlo Hospital, Via Potito Petrone, 1, Potenza 85100, Italy
S- Editor Cheng JX L- Editor A E- Editor Xiong L
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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A lot of fuss has been made about the Michigan State Spartans losing cornerback Darqueze Dennard and safety Isaiah Lewis, both of whom played large roles in last year's "No Fly Zone." A total of only four returning starters on defense means there are many holes that need to be filled if Michigan State wants its defense to compete at the same level it has been the last few years, but quite a few answers are already in place and working, including safety Kurtis Drummond, who is going to have to lead Michigan State's defense in 2014.
Drummond could very well be the Big 10's best safety at the end of the season because of his play-making ability and consistency. In 2013 Drummond recorded 91 tackles in 14 games at safety, which was a career-high and ranked second on the team. Along with that, he recorded four interceptions and six pass break-ups. Drummond naturally benefited from team neglecting to throw to Dennard and Lewis a lot of the time, but it still takes skill to reap those benefits.
Now he becomes Michigan State's biggest weapon on defense this season. It would be unreasonable to expect the same sort of production because the Spartans statistically almost can't get better, and it would be extremely difficult to maintain last season's performance without Dennard And Isaiah, among others.
But Michigan State's defense will be just fine in 2014, and it's largely because of Drummond, who will once again be doing a little bit of everything to keep the Spartans rolling. An early road test against Oregon on Sept. 6 will be one heck of a game to watch, but it will also provide some insight as to how well the secondary will hold up this season. Remember, as much as Oregon loves to speed things up, spread the field and run all over the place, quarterback Marcus Mariota is an underappreciated passer and will test Michigan State's secondary, especially if it tries cheating up.
Drummond is a good pick to lead the Big 10 in interceptions this season and maybe even tackles as well. Because of Michigan State's aggressive play-calling on the defensive end, Drummond will often times find himself breaking into the backfield, something he did a lot of last season.
Without Drummond, a case can be made about Michigan State's defense possibly taking a tumble this season, but as long as he's leading a secondary that will still be competing as the best in the Big 10, don't count on anything falling off the table.
Tyler Fenwick is a Big 10 writer for RantSports.com. Follow him on Twitter @Ty_Fenwick, "Like" him on Facebook or add him to your network on Google.
Michigan State Football: Schedule Preview for 2014
5 Michigan State Football Players Headed for Breakout Seasons in 2014
Michigan State Football: Spartans' 2015 Recruiting Class Building Offensive Firepower

subset: commoncrawl


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Reuters Staff
1 Min Read
Jan 12 (Reuters) - Dr.Reddy's Laboratories Ltd
* Clarifies on news item "FDA to re-audit three Dr.Reddy's labs plants"
* Says believes that schedule of audit by USFDA is usual activity Source text: bit.ly/2j9YDA4 Further company coverage:
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We had the hilarious comedian Owen Benjamin in the studio this morning and we asked all of Central Florida, "Why You Smiling?" Plus psychic Gary Spivey took your calls and we played Florida Or Anywhere Else In The World! All that and more with The Morning MIX podcast:
6am-7am – Comedian Owen Benjamin!
7am-8am – Why You Smiling?
8am-9am – Florida Or Anywhere Else In The World?
9Am-10am – Psychic & Spiritual Healer Gary Spivey!


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Query: Assist with celebs on Twitter?
I want to get more "renowned followers"…but do not know how…any pointers?
Very best answer:
Answer by Spider♥Monkey
There are some celebrities that will adhere to you if you adhere to them.. try out asking and see where that requires you.
Hope I assisted,
how to get twitter followers
Got a far better answer? Hit the comments beneath


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An excerpt from www.HouseOfNames.com archives copyright © 2000 - 2017
Lothian, which was first recorded in the form Crebarrin, from the words Gaelic craobhm meaning "tree," and barran, meaning "hedge."
Carbery Early Origins
Midlothian, where they held a family seat from very ancient times, some say well before the Norman Conquest and the arrival of Duke William at Hastings in 1066 A.D.
Carbery Spelling Variations
Carbery Spelling Variations
Scribes in Medieval Scotland spelled names by sound rather than any set of rules, so an enormous number of spelling variations exist in names of that era. Carbery has been spelled Carberry, Carbarry, Carbery, Carbray, Carbury, Carbrey, Carbry, Carby, Crebarin and many more.
Carbery Early History
Carbery Early History
This web page shows only a small excerpt of our Carbery research. Another 172 words (12 lines of text) covering the year 1230 is included under the topic Early Carbery History in all our PDF Extended History products and printed products wherever possible.
Carbery Early Notables (pre 1700)
Carbery Early Notables (pre 1700)
More information is included under the topic Early Carbery Notables in all our PDF Extended History products and printed products wherever possible.
Carbery In Ireland
Carbery In Ireland
Some of the Carbery family moved to Ireland, but this topic is not covered in this excerpt. Another 261 words (19 lines of text) about their life in Ireland is included in all our PDF Extended History products and printed products wherever possible.
The Great Migration
The Great Migration
The number of Strathclyde Clan families sailing for North America increased steadily as the persecution continued. In the colonies, they could find not only freedom from the iron hand of the English government, but land to settle on. The American War of Independence allowed many of these settlers to prove their independence, while some chose to go to Canada as United Empire Loyalists. Scots played essential roles in the forging of both great nations. Among them:
Carbery Settlers in United States in the 18th Century
Carbery Settlers in United States in the 19th Century
Carbery Settlers in Canada in the 19th Century
Contemporary Notables of the name Carbery (post 1700)
Contemporary Notables of the name Carbery (post 1700)
Carbery Family Crest Products
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The Carbery Family Crest was acquired from the Houseofnames.com archives. The Carbery Family Crest was drawn according to heraldic standards based on published blazons. We generally include the oldest published family crest once associated with each surname.
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(01-14-2013, 03:21 PM)DeepBreath Wrote:(01-14-2013, 12:31 AM)PaulaO2 Wrote: I just don't see how a single fatty meal would interfere with the lung/heart O2/CO2 exchange for the same night. I can see how perhaps it would make you sleep deeper since you are fuller. Or it would perhaps make you sleep lighter because you are fuller or indigestion. But those factors would add more obstructive events, not more central events.
Unless I'm missing something, I don't believe he is suggesting the fatty meal is affecting his lung/heart O2/CO2 exchange. Rather, he's postulating that it's impacting his brain function (in a positive way) and resulting in less CAs.
I don't think he's trying to convince anyone to go buy virgin coconut oil, but it's an interesting observation. I appreciate him sharing it with the forum!
The O2/CO2 exchange is the reason we breathe. With central apnea, the brain is confused as to the amount of each and doesn't see a reason to breathe. So what I said was, I don't see how a high fat meal could confuse the brain.
Apnea Board Moderator
Breathe deeply and count to zen.


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GEOMETRY CHAPTER 2 JOURNAL. VALERIA IBARGUEN 9-1. CONDITIONAL STATEMENT. This is a type of statement that can be written in a form of " if p , then q " P= Hypothesis Q= conclusion EXAMPLES: If m<A =195°, then <A is obtuse
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5, 52 > 5
5, 25 > 5
hypothesis: twosegments are congruent
conclusion: theyhavethesamelenght
ThegivenAB≅XYstatementsdoes match thehypothesis so theconjecture IS true.
Conjecture: John wastardy at least 3 times.
hypothesis: you are tardy 3 times
conclusion: youmustgotodetention.
Thestatementgiventousmatchestheconclusionof a trueconditiona, butthehypothesisisnottruesince John can be in detentionforanotherreason so theconjectureis NOT valid.
p= themeasureofanangleislessthen 90°
q= theangleisacute
r= theangleisnot a rightangle.
-Thisistryingtoexplainusthatpqandqristheconclusionofthefirstconditionalandthehypothesisofthesecondconditionalyou can tellthat at the en pr. So IT IS VALID
Conjecture: If a numberis divisible by 4, thenitis even.
p= A numberis divisible by 4
q= A numberis divisible by 2
r= A numberis even
-Whatthismeansisthatpqandrq. TheLawofSyllogismcannot be usedtodrawconclusionssinceqistheconlcusionofbothconditionalstatements, even thoughpristruethelogicusedtodratheconclusionisNOT VALID.
a)Prove: x=2 if
Given: 2x-6=4x-10
Given: angle<1 and < 2 are linear pair
Prove: <1 and <2 supplementary.
Given: <1 and <2 are supplementary <3 and <4 are supplementary.
Given: BE ≅ CE, DE ≅ AE
Prove: AB ≅ CD


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Perrie Edwards wants children with Zayn Malik in the next three years.
The 'Black Magic' hitmaker has revealed she is keen for her and her fiancé to have a baby by the time she turns 24.
When asked how old she'd want to be when she has her first child, she said: "Well, I would say 24 and that's in three years' time for me. It's still quite a while away.
"My mam was 24, though, so that's always been my ideal age."
The 21-year-old singer has been blamed for Zayn's hasty departure from One Direction but she has insisted it was solely his choice.
She added: "People have said did I do this, did I do that? No matter what decision he made, I was always going to support him. If he'd wanted to stay, I would have supported him just the same as I have done since he's left ... If he's happy then I'm happy.
"He's really good. Hopefully everyone understands that it was one of the hardest decisions he's ever made in his life."
The pair are now looking forward to taking their time planning their wedding but the Little Mix star's mother Debbie is keen to see her daughter walk down the aisle as soon as possible.
When asked if wedding plans had progressed, Perrie told The Sun newspaper's Fabulous magazine: "Not yet, but me mam can't wait and it's getting on me nerves.
"She's like, 'What about the flowers? What about this dress?' And I'm like, 'Mam, stop!' We've been so busy, but I literally cannot wait to start planning my wedding."


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Profile: Washington Post Reports U.S Special Forces Troops are Already Working Inside Iraq
All Things Considered: February 13, 2003
LYNN NEARY, host:
From NPR News, this is ALL THINGS CONSIDERED. I'm Lynn Neary.
ROBERT SIEGEL, host:
And I'm Robert Siegel.
President Bush told troops in Florida today, if war with Iraq should come, America will act deliberately, decisively and victoriously. Administration officials have repeated that the president has not yet decided whether to order a war, but all the elements for military action are, nevertheless, falling into place. Thousands of additional US troops are arriving each day in the region around Iraq. And now, there's a report that some special operations troops are already on the ground behind Iraqi lines. From the Pentagon, NPR's Tom Gjelten reports.
TOM GJELTEN reporting:
The first confirmation of a US military presence in Iraq came two weeks ago when the chairman of the Joint Chiefs, General Richard Myers, said there was a small number of US forces in northern Iraq. Defense officials said those US troops were operating in Kurdish-controlled areas outside the reach of the Iraqi army. Their mission: to link up with Kurdish rebel forces and begin setting up airfields and other operational bases. Today, The Washington Post reported that US special operations forces are actually in various parts of Iraq, with some already hunting for weapons sites. One aim would be to prevent the Iraqis from launching a missile attack, like the ones carried out with Scuds in 1991. The Post reported that the activity of the special operations troops amounts to the initial ground phase of an Iraq war.
A senior Defense official confirms that the activity of special US forces inside Iraq has extended beyond Kurdish-controlled areas, though he says the US presence inside Iraq is, quote, "not as significant," unquote, as portrayed in The Post article. He would not elaborate.
It is no surprise that a US engagement in Iraq would begin with special operating forces. That's the way the war in Afghanistan began in the fall of 2001. In fact, the 1991 Gulf War also began with special ground operations even before the start of the bombing campaign. Retired Major General Robert Scales wrote the official Army history of the war.
Major General ROBERT SCALES: In the period prior to the beginning of the campaign, these forces were used to do several things. Number one, most importantly, find the Scuds. Secondly, to determine what the Iraqi army was really doing. You know, it's one thing to count tanks on the front lines. It's something else to get a sense of what the Iraqi army was all about.
GJELTEN: In the 1991 Gulf War, US troops did not link up with rebel forces. This time around, the United States would be likely to work in the north with Kurdish groups and in the south with Iraqi Shiites. Establishing those contacts early will be a key mission of special US forces.
Another new use of Special Forces in a second Gulf War would be to secure the Iraqi oil fields, even before bombing begins. That could mean the first military action in Iraq would be on the ground, not in the air. But Scales, a former commandant of the Army War College, says he expects any such engagement would be minimal. US military commanders, Scales says, may not want to begin a war in Iraq with small, stealthy steps.
Maj. Gen. SCALES: Once the campaign starts, the military will do all it can to do one of two things. Number one is to set the enemy in place, and secondly, to psychologically intimidate him, and to do it principally with firepower in the opening days of the campaign. The only way you can do that is to apply what Colin Powell used to call the principle of overwhelming force. And so, I think once the actual campaign begins, everybody's going to know about it.
GJELTEN: Pentagon officials are extremely reluctant to discuss upcoming operations. In the fall of 2001, when the news was leaked that special US forces were on the ground in Afghanistan, Defense Secretary Donald Rumsfeld was outraged. And when asked at a Senate hearing today about The Washington Post story, Rumsfeld launched another attack on leaks and leakers.
Secretary DONALD RUMSFELD (Defense Department): I think they're disgraceful. They're unprofessional. They're dangerous. They put people's lives at risk. I would also add that I think it's the obligation of people who find people leaking to tell responsible authorities because folks that do it and put people's lives at risk ought to be in jail.
GJELTEN: In fact, the Pentagon has become increasingly open about the US military buildup around Iraq. Defense officials say reports of growing US combat strength put pressure on Saddam Hussein. The news that US troops may already be on his territory might just add to that pressure. Tom Gjelten, NPR News, the Pentagon.
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Dallas Cowboys Nike Heritage Snap 2 Cap
The Official Store of the Dallas Cowboys brings you the Dallas Cowboys Nike Heritage Snap 2 Cap. This Nike throwback cap will be a great addition to your Cowboys collection for seasons to come.
- Nike brand flat bill cap
- 100% Cotton with polyester underbill
- Embroidered Dallas Cowboys wordmark on front, Cowboys star logo on right side, Nike logo on left side
- Officially licensed NFL product
Nike was started by two visionaries- Bill Bowerman, legendary track & field coach at the University of Oregon and his University of Oregon runner Phil Knight. Today NIKE, Inc. is the world's leading innovator in athletic footwear, apparel, equipment and accessories. Nike's mission is to bring inspiration and innovation to every athlete* in the world. The Official Shop of the Dallas Cowboys is proud to sell Nike apparel to loyal Cowboys fans everywhere.
*"If you have a body, you are an athlete." -Bill Bowerman


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Monthly Archives: April 2016
Splodey Vaders Update #02: GaMaYo
I showed Splodey Vaders off at GaMaYo last week. GaMaYo stands for Game Makers Yorkshire and is a networking event held twice a year where game developers from across the region and beyond get together, have a few pints and play each other's games. I've been to GaMaYo a few times and have even shown some games there, but never on one of the big screens like I did at this one. It was a great experience and I recommend anyone to give it a try if you've got a game people can play. At one point there was even a kind of queue for Splodey Vaders, which was awesome. A big thank you to everyone who came and played.
I got some great feedback for Splodey Vaders from a bunch of people. Most of the comments where positive with some people seemingly becoming addicted, which was great. These people from Clubit TV came round and did a quick interview with me about the game, though I haven't seen any of it surface online yet. I was showing the PC version on the big screen, while walking around shoving my NVIDIA Sheild into peoples faces to play the Android version.
What's Next?
I want to get the game uploaded to Game Jolt, ideally in a state which integrates with Game Jolts high score system, so that users can compete to become top of the leader board. I also need to get the game to save your score after you shut it down rather than resetting every time. After that, I want to update the sprites for the player and the Vaders (the current sprites are placeholder) and make them animated. There's all kinds of additional features planned, but as usually, you can check what's planned on the game's Trello: https://trello.com/b/jTalmHfR/splodey-vaders
Splodey Vaders Update #01 – Preparing for Ga Ma Yo
As I mentioned in the original post about Splodey Vaders, I'm planning on showing it at an event targeted at local game developers. I've never done anything like this before, other than Adventure X back in 2011. I plan on writing a post detailing how the event went, but before then I wanted to write an update on the progress of the game and outline some key features:
Score Multiplier
In Splodey Vaders when you shoot a Vader, they Splode. When they Splode, chunks of Vader go flying around the screen. If a Vader chunk hits another Vader, they Splode. This mechanic allows the player to create chain reactions where there are explosions happening all over the screen and multiple enemies are being killed. In the early stages of development, you would receive 10 points if you hit a Vader. If the chunks from that Vader hit another Vader, then you would get a score multiplier. This would times whatever the current score multiplier was by 10, in this case, giving you an extra 100 points. If the chunks from *that* Vader hit *another* Vader, then it would times the score multiplier by 10 again, giving the player 1000 points. This could get out of hand very quickly with some players getting scores of 10,000,000+. I decided to add a cap to this and reduce the amount your score can multiply by. If you shoot a Vader you still get 10 points, but if the chunks from that Vader hit another Vader then you get a multiplier of X2, giving you 20 points. You can then get X5 and X10 score multipliers by causing chain reactions with Vader chunks (you also get a nice pop up and sound effect telling you you've done so). All subsequent Vaders hit would be capped at X10 meaning that the maximum points you can get from any one Vader Sploding is 100. The score multipliers and chain reaction of explosions is a core part of the game. I also made the score pulse whenever you add to your score as an added visual que that you are earning points.
Sort of related to the score multipliers is the trail effects added to the Vader chunks. These can be different colours and the different colours correspond to whichever multiplier you have achieved. Initial chunks have a blue trail and if they hit any Vaders, the player will receive X2 score multiplier. The chunks from that Vader will have a red trail and the player will receive X5 score multiplier. The chunks from that Vader will have a white trail and the player will gain X10 score multiplier. The pop up text you receive for X2, X5 and X10 are also colour coordinated to match with the trail colours.
Controller Support
I've never added controller support to a game before, but it was incredibly easy to do in Game Maker. I decided to make it so that you can use D-Pad, either Analogue stick, shoulder buttons, trigger buttons or face buttons for movement to allow the player freedom of choice.
In the game, Vaders can go past the bottom of the screen and it's not game over. It's only game over if you get hit by a Vader or a chunk from a Vader. However, I wanted to add some form of penalty to the player for letting a Vader get past. My initial idea was to have the Vader respawn at the top of the screen, but slightly faster and moving towards the player's location like a homing missile. This idea came from Super Crate Box, where enemies will respawn at the top of the screen faster than before. This doesn't penalise you in terms of your score for letting enemies past, but if you DON'T shoot them, the game will become harder. I also toyed around with the idea of having Vaders explode when they reach the bottom of the screen, but this proved too difficult to avoid the chunks firing out of the Vader. At the moment, nothing happens when the Vaders go past the bottom of the screen, the only penalty is the loss of potential points you could have got had you shot the Vader, but I may change this later on.
A lot of players seemed to find the game too hard to begin with. To combat this, I've made the base speed of the Vaders slower, made less Vader chunks fly out when they explode and reduced the maximum speed that a Vader chunk can have making it easier to avoid them. After showing the game to groups familiar and unfamiliar with the game I think I've found a good balance.
Other Changes
- Fixed bug where text was misaligned
- Made it more obvious when you die (red flash appears)
- Stopped the infinite Vader spawning on Game Over
- Improved Game Over Screen
- Background speed now increases with game speed
- Fixed bug which caused all objects (including the Vaders and Player Ship) to disappear when Score Multiplier text faded out.
If you want to see the current road map for Splodey Vaders, I'm using Trello to track changes, fixes and features for the game. It's an awesome site that allows you to easily track the development of a project. Splode Vaders Trello: https://trello.com/b/jTalmHfR/splodey-vaders
What Next?
Well Ga Ma Yo is on Thursday and I'll be showing the game off there and hopefully gaining some good feedback from the cornucopia of developers there. After that I'll be creating a PC version ready to make available on websites like Game Jolt and itch.io. The next major features to be added will be saving high scores after a session and beyond that some art updates and maybe different enemy types and power ups! In the meantime, here's a video which shows off some of the gameplay from Splodey Vaders:


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Mapex B60 Mars Series Cymbal Boom Arm
The Mapex Mars Series cymbal boom arm is a quick and affordable way of mounting extra cymbals on your set up.
Main Features
- 3/4 inch tube
- Hideaway boom
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- Geared tilter
- Fits any clamp jaws
The Mapex Mars Series cymbal boom arm is a quick and affordable way of mounting extra cymbals on your set up.
The 3/4 inch tube fits any adjustable clamp jaws while the hideaway boom arm stores away for transport. The knurled cymbal arm keeps the cymbal secure, while the geared tilter allows you to place the cymbal precisely.
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This item is normally sent to Mainland UK addresses by DPD who generally provide a one-hour window of delivery on the morning of delivery by email or text message. If you need this item faster, please upgrade to a Before 12 service at checkout.
Mainland UK: £3.50 within mainland UK ( Orders over £99 are delivered FREE )
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1 Recommended Accessory
Additional Information
Brand Mapex Condition New


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Given that the average coaching relationship on the ATP Tour lasts about 18 months, you could argue that Ivan Lendl's stint with Andy Murray – which extended just a couple of months over two years – did better than expected.
However, the odd thing is that they should abandon a partnership that has been so blazingly successful.
I understand that Ivan has other things in his life that he wants to attend to, including the sort of senior exhibition matches that he played against Pat Cash in London at the start of this month.
But how much time does Ivan actually need to spend with Andy to make a contribution? You would have thought they could come up with a reduced deal, maybe for 10 weeks a year rather than 20. Stefan Edberg is doing 10 weeks with Roger Federer this season and has already had a transformative effect.
When coaches and players break up, it is usually for one of three reasons. The first is finance – which should not be a problem in this case. The second is because the player has outgrown the relationship. Again, that does not apply here.
The third reason is because the two parties differ on what the player can achieve and how he can get there. Maybe Ivan felt he had contributed everything he had to their partnership.
After Andy underwent back surgery in September and missed a couple of months, there was no real prospect of him climbing to No 1 in the world in the near future. I am just surprised that they didn't want to go back to Wimbledon in the summer and try to defend that title together.
Ivan will be a hard man to replace. Right now, the two outstanding coaches on the tour are probably Marian Vajda, who helped Novak Djokovic get back to winning ways in Indian Wells last week, and Edberg.
Ivan was up there on the same level, in terms of the contribution he made to Andy's tactical awareness and mental approach. The two of them just hit it off from the beginning and developed a real mutual understanding.
At his best, Andy achieved clarity of thought with Ivan's assistance and that is when you can deliver great results and win big titles. Watching him in Indian Wells last week, he just did not have the same certainty. He was playing more drop shots than I have ever seen; it felt as if he did not want to let the rallies get too long.
The after-effects of back surgery were always going to be hard to deal with. In all probability, Andy has not been able to put in as much work as he would have liked off the court.
It does not take much to knock your game off its stride; just look at Federer, again, who had a few back issues after Indian Wells last year and found himself trying to end points too quickly. It took him the whole season to get back on track, and now he is moving about as well as he ever has.
Ivan had two options, then: to sit in there through a difficult time or go out on a high, and I guess we have just seen his decision. Injuries are often a catalyst for change in sport. My own split with Tony Pickard in 1998 came about after I damaged an ankle and we had different ideas about how to deal with it.
Andy has a strong support team even without Ivan. Dani Vallverdu has known him since they were kids together at the Sanchez-Casal Academy in Barcelona, and will take over coaching duties in the short term.
There is also Andy's connection with Darren Cahill, who can act as an adviser through his role at Team Adidas. But I would expect him to look around for a new man, and I would hope that someone comes in before the French Open.
Andy has a relatively quiet period coming up. He will not be defending many points once the European clay-court season begins, which should give him an opportunity to consider his options. It is a shame that, because of Andy's back trouble, he was never able to have a real go at the clay with Ivan – a man who won three French Opens.
Neither, strangely, did Ivan ever coach Andy against Rafael Nadal. That would have been an interesting match to watch, because Ivan's bespoke plans for the other members of the "Big Four" were very astute.
The story goes that, when they first sat down to discuss working together at a pizza joint in Florida, Ivan sketched out his tactics on a paper napkin.
Andy is a fantastic player and should have many more years in the top 10 to come. But Ivan's departure is a blow. There are very few coaches who can add another dimension in the way that he has done.
Without him, it will be that bit harder for Andy to lift his momentum and intensity in the build-up to his Wimbledon title defence.


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Tove Hensler
I am the Lab Manager at Emotion Lab. Concurrently, I am finishing my Master of Science in Psychology at Karolinska Institutet. My thesis project is focused on moral judgments and decision making. Alongside my studies, I have worked as a research assistant at Karolinska Institutet's Department of Neuroscience and Department of Clinical Neuroscience. I spent one semester as a visiting student at University of Zurich, where I was involved in research under the chair of Biopsychology. Before coming to KI, I studied cognitive science at Linköping University.
Email: tove.hensler (at) ki.se


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Edward Scissorhands by Cataclysm-XWatch
©2004-2017 Cataclysm-X
I forgot to put Edward in my gallery! This drawing is quite old, but I like it a lot, so you guys can't miss it.
Eddy! OMG best movie ever!! This drawing just- Brilliant!! O_O
You have amazing skills!!!
Holy crap this is drawn?
I love it!
killer killer drawing! awesome!
I'm really going to draw this picture myself! Very good work, my picture will not be that good at all xD
where are the scars?
lol oh c'mon, I was new at drawing portraits back then I wouldn't forget the scars these days!
well done
Oh nutty buddies!
lmao You DO have Edward in your gallery haha!
lmao You DO have Edward in your gallery haha!
Amazing! Looks a lot like Johnny. Johnny Depp---the actor.
What did you use to draw this?
What did you use to draw this?
i just love eddy great film and great drawing
god job
Awesome drawing!!!
I love Johnny Depp!!!
I love Johnny Depp!!!
wow this is amazing.... you've got great skills!
this is really awesome!
u really have talent!
nice work!
u really have talent!
nice work!
Wonderful drawing!!
I love the movie
*passes out*
I love that movie! It looks just like him ^^ Fav. worthy!!!!!
Hi I was wondering, would you mind if I used your pic to make a button (an 88x31 image connected to a link) for a site that I'm a part of called Beburtonesque located here:
I would give you credit for it. I would be submitting it into a button contest so at this point there is no way to know for sure if they'll use it but I'd like your permission just in case.
I would give you credit for it. I would be submitting it into a button contest so at this point there is no way to know for sure if they'll use it but I'd like your permission just in case.
Yes, I drew him, too. I love this film. I always cry in the end.:-D
i loved that movie, and your whole actor folder in your gallery is just amazing.
Ooooooooh I love him! <333
haha en ik maar engels praten!
geweldig knap !
geweldig knap !
That was my disguise in Halloween 2007.
That was my disguise in Halloween 2007.
Oh... I don't have right words to say what feelings that pic awakens in me. I just love that movie, Johnny Depp is one of my favourite actors. And Edward... He's just too lovable character, and the movie is something too great to describe. (And yes, everytime I see that movie, I start to cry in the end... =.=' ) I really and truly love that picture. Thank you very much. -^_^-
Aw man, I wanted to watched this movie but my parents wouldnt let me = =''' Awesome portrait of Edward
Very nicely done!
very nice one!
One of my friends did a pointalism of this exact shot.
Edward Scissorhands rocks!
Edward Scissorhands rocks!
geweldig mooi !!
Wow I drew this same picture its horrible tho, compared to yours. Very nice. I made him look like a witch, but whatever.
LoL a witch?
LoL a witch?
mhm, I'm guessing that you haven't seen it. It looks nothing like the picture I was looking at, and he's not even looking down like he's supposed to.
If you want to look at the horribleness, you are free to look at it in my gallery, but be warned lol.
If you want to look at the horribleness, you are free to look at it in my gallery, but be warned lol.
Aww Edward.
Once Again, Bravo!
Your so good!
Once Again, Bravo!
Your so good!
i love this movie!!! awesome job!
Love this character....really good movie even if he is old.....
You done this drawing beautifully.
You done this drawing beautifully.
god your work from so long ago is still amazing
I love Edward Scissorhands. ^_^ AWESOME movie! Again your talent never seizes to amaze me. I can't wait to see what you do next. ^_^


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My Dreamy WWDC 2013 OS X 10.9 Grumpy Cat Wishlist
From User Point of View
Seamless iCloud synchronization of apps preferences, at least the system ones like Mail.app
I have a pair of notebooks and sometimes I have to switch between them. One thing I find really tedious is tweaking the preferences, so they match your workflow on the previous machine. Finder, Mail, Xcode... in my case preferences are always out of sync, because I change my mind from time to time.
Seamless iCloud synchronization of the Dock
There is a famous Henri Ford' saying "If I had asked people what they wanted, they would have said faster horses.". For now I am just asking about better Dock. This concept could change dramatically in the next major OS X release, but for now iCloud synchronization of its items would be enough.
Seamless iCloud synchronization of the Keychain
Ok, this thing is so obvious, I can hardly believe it's not already implemented in Mountain Lion. The only fact that conciliates me about this unimplemented feature is current iCloud state is a mess: one can't build a reliable system from completely broken components.
Better Finder' AirDrop
Sometimes it's convenient to transfer files within your local network using AirDrop. One thing that bothers me about this feature is its requirement for both parties simultaneously entering "AirDrop" mode in their Finders. If both MacBooks are mine and they stand on the same table I have to click too many times to simply transfer file from one Mac to another. Synchronization across the Web would be nice to have too. Btw, now I simply use Dropbox.
Silent update of the Mac App Store applications
Why for the God's sake we have to manually trigger the app updates and enter passwords again and again? For what reason password is mandatory? For a person who have many apps installed on their Mac this recurring process becomes maddening.
From Developer Point of View
Remove, or at least deprecate the obsolete NSButton types and styles
Why to keep these utterly obsolete button styles, if nobody is going/allowed by HIG to use them? Beveled buttons, square ones... wipe them out from the IB and UIKit, we don't need broken blocks in our LEGOs.
Completely get rid of NSCell class
Born for performance improvement this class is superfluous in 2013. NSCell introduces incredible mess in control customization. The idea to customize anything through the inheritance is questionable by itself and NSCell/NSControl pairing makes it close to impossible.
Give us standard tabs control like in Safari and Xcode
It's impossible to understand why this still didn't happen. Apple seems to be using the same control in Safari and Xcode for a couple of years already, though developers are not able to benefit from it too. Building your own tabs control is a time consuming task and existing solutions like ChromeTabs just don't feel native enough.
Fix File Coordination
I love the idea of file coordination, introduced in Lion. Possibly, it is the only sane way to serialize access to filesystem in user-space. The sad thing is it's half baked, buggy and not mandatory for anyone to implement. Apple pretty successfully addressed concurrency problem with Grand Central Dispatch. It made our lives easier with introduction of Automated Reference Counting. Could file coordination be turned into a real working solution to file system concurrent access problem? I hope so.
Fix Interface Builder Auto Layout support
To put it mildly, Interface Builder and Auto Layout didn't play well together. I really love Auto Layout by itself (though I permanently still have problems with it). The API is clever and innovative, it amuses me how it was been retrofitted into the aged AppKit. Long ago I stopped fighting the IB and begin to layout simple views in code. I still configure leaf-views in IB, but then programmatically setup their dependancies in code using constraints.
Innovation in language design
During the last years numerous developers turned to the functional programming languages feared by unmanageable mutable program state in multithreaded environments. Brightest GitHub guys released awesome and highly innovative ReactiveCocoa framework implementing Functional Reactive Programming (FRP) paradigm, that I my opinion conciliates both worlds: imperative and functional. Unfortunately, to this stuff be completely usable it should be universally embedded in the Cocoa.


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DALLAS - Twins center fielder Denard Span apparently is off the market, the Nationals continue to express an interest in Cuban outfielder Yoenis Cespedes and if they don't land the leadoff hitter/center fielder they've established as a priority for the offseason, the Nats are confident Ian Desmond can handle the job at the top of the lineup.
General manager Mike Rizzo covered a lot of ground during his afternoon briefing with reporters - just like the swift flychaser he wants patrolling the spacious gaps at Nationals Park - but it appears the Nats remain in wait-and-see mode when it comes to their center field opening.
Twins GM Terry Ryan apparently took Span out of the mix Wednesday, perhaps because he's concerned the player isn't fully recovered from the concussion that cut short his 2011 season and maybe because the Twins want to make sure they have some outfield inventory while they are awaiting a decision from free agent Michael Cuddyer, who they hope to re-sign.
"I've spoken to Terry a couple of times. If he says (Span is) off the market, he hasn't said that to me. I haven't heard him said that. He hasn't said that to me," he said. "If he said that, they're probably waiting to see if Denard's healthy, over the concussion, and to see what his value is as a healthy player."
With nothing on the front burner as far as a center fielder, Rizzo will wait and see how the market develops. He's spoken with a number of clubs, sometimes inquiring about veterans, sometimes looking at top minor leaguers whose progress to the major leagues may be blocked.
"We're in discussions with a bunch of teams," Rizzo said. "We've got a lot of lines in the water. These things usually have a synergy of their own and when we get some momentum, things can happen. We're not going to force anything. It has to be the right fit and the right acquisition cost for the player."
One name that still intrigues the Nationals is 26-year-old Cuban Yoenis Cespedes, who must still establish residency in the Dominican Republic before Major League Baseball will declare him a free agent. Rizzo saw Cespedes in person in a workout in the Dominican shortly after Thanksgiving and remains interested in him.
"We've scouted him very thoroughly," Rizzo said of Cespedes, a right-handed hitter who started for Cuba in the 2009 World Baseball Classic and defected to the Dominican Republic earlier this year. "We like the player. He's a great talent, (but) he's an unproven commodity in our minds. He's one of several options that we're considering."
Cespedes is considered a potential five-tool player, but there are questions how quickly he can adapt to the American style of baseball.
"I've seen him in a workout scenario, so it's a little more difficult for me to say," Rizzo said. "Our scouts have scouted him in games. They like his skill set. I think it's to be determined if he's immediately major league-ready or whether he'd have to get a little flavor of the American game down in the minor leagues before he gets brought up. What I've found in my experience, the Cuban player takes a while to acclimate to the U.S. game. He may be an exception, but to me, that's the norm I've found."
With left-hander Mark Buehrle off the board now that he's signed with the Marlins, the Nationals probably don't have sufficient pitching depth to include a starting pitcher in a trade for a center fielder. That could mean shortstop Ian Desmond returns as a leadoff hitter in 2012, a role in which he batted .281 in 50 games, mostly during the second half.
Rizzo's preference remains to find a leadoff hitter who can play center field. But if he can't, Rizzo doesn't mind starting 2012 with Desmond atop the lineup.
"Davey and I both feel comfortable that Ian can hit at the top of the lineup, so we feel good about that," Rizzo said. "Run creation is done a lot of different ways. He may not be the optimum leadoff hitter, but we feel he has the skill set to do so and we can be an effective lineup with him at the top."


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clowny wrote:LMAO. It's incredible how delusional you people are.
I'm sure women like this have guys lusting after them all over the place.
Yeah, even those ugly ass women will at least 5 guys wanting them in their entire lives. It sucks for you to know the truth, I know


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Saturday, October 13, 2012
Pumpkin Spice Muffins!
Last night I made these super delicious pumpkin spice muffins, and I've already had two today for breakfast. I can't stop. If you want to make the same ones, it's super easy and doesn't even require a real recipe. Here's how I did it!
1. Go and buy pumpkin muffin mix. I bought Kroger's Pumpkin Quick Bread and Muffin Mix, which can be made into... you guessed it, bread or muffins. You could probably buy pumpkin bread mix and just pop it into a muffin pan instead of a bread pan; I'm pretty sure the recipe is the same, or quite similar!
2. Pour the mix into a big mixing bowl. And here's the trick: before adding any of the wet ingredients (water, oil, eggs), put in some sneaky spices! These are pumpkin spice muffins, after all. I added cinnamon, nutmeg, ginger, and cloves (all ground). It's ultimately up to you how much of each spice you want to add, but I added a bit more cinnamon than the others (a few dashes), a couple dashes of cloves, a dash of ginger, and a dash of nutmeg. It doesn't seem like a lot but it will make the pumpkin muffins taste just like your favorite Starbucks pumpkin spice latte!
3. Follow the instructions on the side of the box. My recipe called for a cup of water (or milk), 1/3 cup of vegetable/canola oil, and 2 eggs. You should probs follow the recipe that goes with your mix though!
4. Bake, eat, and enjoy!
I know this is totally not even a real ~recipe~, as it's just boxed mix with a few spices added in, but who knows, maybe somebody will be glad of the help! I had an issue finding spice cake mix, which I guess becomes pumpkin spice muffins if you add pureed pumpkin, so I just did it my way instead. I'm sure there are a billion different methods for making pumpkin spice muffins out in the world, but hey, here's how I did it! x
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(Blatant plug: This week, I wrote about the University of Memphis Livable Mid-South conference on transportation for our print issue. You should pick it up while you're out and about, OR you can click here.)
The Memphis Metropolitan Planning Organization (MPO) has moved into the next phase of its Imagine 2035 process. Now that the first round of public meetings is complete, the MPO is going to draft three different drafts of its land-use and transportation plan.
The first will show how things will develop if the area takes a "business as usual" approach, basically how development will continue for the next 25 years if we stay on our present course.
The second draft will show alternative scenarios, and the third will be the ideal scenario.
From what I recall, Nashville did this several years ago with Cumberland Region Tomorrow's Report to the Region and found it very helpful, especially comparing the "business as usual" approach to the ideal one.
The Report to the Region was published in 2003 and laid out the results of the 2001-2002 Regional Visioning Project showing how the 10-county region was growing and what could potentially happen if we continue to grow with business as usual planning and development practices.
Apparently, seeing where they were headed was enough to convince citizens that changes needed to be made.
Locally, the MPO should come back with its scenarios — and the next round of public meetings — in August. In the meantime, you can find them on Facebook or you can contact the MPO for a "meeting in a box."
Like Aaron Woolf says, I know transportation isn't the sexiest topics, but in terms of economic development and people's quality of life, it's really important to think about.
Do I really have to list the reasons why? No? Good.
Last week, I took a trip to Chicago, riding a double-decker bus from MATA's north terminal on Main Street to Union Station in Chicago to get there. On the way back, I took Amtrak. (Amtrak was much better than the bus, but it was also about three times as expensive. The bus fare was *very* affordable.)
While I was in Chicago, I also took a cab, grabbed a few rides in cars, and used the L every single day. Oh, and there was a lot of walking.
I think the only other means of transportation I might have missed was bicycling. But I have my chance to make up for it tomorrow when it's national Bike to Work Day!
Downtown is all over this this year, and the Center City Commission has organized several meet-up locations for people who want to ride with other people into downtown (let's be honest. If this is the first time you're riding a bike into work, it might be more safe, to hit the road with other people.)
Meet-ups are at Eastgate shopping center, the Brooks, and Otherlands. There is also a bike-to-work energizer center at Main & Greenlaw, and a bike-to-work event at Court Square from 11 a.m. to 1:30 p.m.
(Now all I have to do is find someone to loan me a bike.)
For our print edition this week, I wrote about the recent Livable Mid-South conference on transportation at the University of Memphis.
One of the speakers, Marianne Fowler, works with the national Rails-To-Trails Conservancy. The group is currently promoting the Active Community Transportation Act of 2010, which was introduced in Congress in March and would establish competitive funding for walking and bicycling improvements in targeted communities.
I think we all know how much we, as a nation, drive. But I thought it was interesting to hear how much of those trips are actually quite short. (And maybe even walkable or bicyclable?)
Twenty-seven percent of all automobile trips in this country are one mile or less.
Forty-eight percent are three miles or less.
"It's not our fault," Fowler says. "We live in an environment where that's almost required."
Attn: Cyclists, Public Transportation Users, Pedestrians, Motorists, and Light-Rail enthusiasts:
The MPO, the Memphis Metropolitan Planning Organization, begins its new long-term transportation planning initiative this month. I know, I know, it sounds like a snooze-fest, but it's really important, especially if you want to give input into how people in the region will get around for the next 25 years.
Imagine 2035 will stress the need to coordinate transportation and land-use planning and show where new growth and development is likely to occur.
"This process will give our community the chance to discuss the 'what-ifs' of our metropolitan area, and consider the trade-offs between how our community grows and the transportation decisions needed to support that growth," says Martha Lott, MPO administrator.
"This is a great chance for the community to not only see what our region might look like 25 years from now, but also take an active part in shaping its future," adds Brett Roler, IMAGINE 2035 Project Manager.
The first meeting is next Monday, April 19th, from 7 to 8:30 p.m. at Arlington Town Hall. To see the list of the rest of the meetings, click through.


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(click linked text below to jump to related section of the review)
- The Movie Itself
- 4 Stars
- HD Video Quality
- 3 Stars
- HD Audio Quality
- 2.5 Stars
- Supplements
- 0 Stars
- High-Def Extras
- 0 Stars
- Bottom Line
- Worth a Look
Peanuts: Snoopy, Come Home
- Street Date:
- September 6th, 2016
- Reviewed by:
- Aaron Peck
- Review Date: 1
- December 27th, 2016
- Movie Release Year:
- 1972
- Studio:
- Paramount Home Entertainment
- Length:
- 81 Minutes
- Release Country
- United States
The Movie Itself: Our Reviewer's Take
'Snoopy Come Home' is one of the most touching Peanuts movies out there. Released in 1972, it works to combat the cynicism and negativity that 'A Boy Named Charlie Brown' (1969) harbored. At its simplest it's a moving story about a boy and his dog. At its most profound it's a look at how discrimination affects us and moves us to act.
Snoopy is living his wonderful, carefree Snoopy life. Until the town starts putting up "No Dogs Allowed" signs everywhere. Snoopy is incensed by this. It's especially troubling because Snoopy is an anthropomorphic dog. Doesn't matter though. Doesn't matter how smart Snoopy is or that he chooses to walk on two feet instead of four, he's still banned from the beach, the library, and the hospital.
In an attempt to sway public opinion Snoopy, with Woodstock's secretarial help, pens a letter to the editor highlighting the injustices being committed against dogkind.
A small hospitalized girl reads Snoopy's letter and writes to him. Snoopy, after reading the girl's letter, packs up his belongings, says goodbye to his best friend Charlie Brown, and sets off to find the little girl.
For a Peanuts movie, this one sure packs a lot of emotion. There's Snoopy, who has to bid farewell to his life back home and Charlie. There's Charlie, who becomes more distraught about his dog leaving with each day that passes, and then there's this little girl who wants Snoopy to come live with her.
Some tough choices are made. Real consequences are faced head on and feelings are hurt, mended, but never put back together the same way. I may be looking too deeply into a Peanuts movie, but I feel like there's a lot to be gleaned here.
Driven by discrimination, Snoopy decides to do something about it. He petitions the press and finds a way in which he can, to him, make things better again. Then there's this idea that Snoopy must choose. Even though we know that Charlie and Snoopy are going to be together for a long while, we're still left wondering why exactly Snoopy is having such a hard time choosing. Even Lucy can't help but miss the loveable mutt.
One of the best things about 'Snoopy Come Home' was the decision to hand over the music and lyrics responsibilities to the incomparable Sherman brothers. They craft some catchy, heartfelt tunes that simply blow the mean-spirited songs of 'A Boy Named Charlie Brown' out of the proverbial water. A highlight being the song "Fundamental Friend Dependability," which is sung by a young girl who attempts to keep Snoopy at her house in the middle of his journey. It's a fun, memorable song that has a specific Sherman signature.
'Snoopy Comes Home' provides some of the best qualities the Peanuts franchise has to offer. It doesn't spend its time incessantly tearing Charlie Brown down, but instead it lets him deal with real feelings of loss and loneliness in a way that's relatable. Animated tears are shed, and maybe a few real ones too. It's a great little film, and one to cherish.
The Blu-ray: Vital Disc Stats
This is a single-disc release that comes with a 25GB Blu-ray. The only other thing included is a slipcover.
The Video: Sizing Up the Picture
Don't try to adjust the settings on your TV aspect ratio when the movie first starts up. That's because it begins with black bars on the sides and the top, with a small viewable window in the middle. This is only during the beginning credits. After that the image expands to the expected 4:3 aspect ratio.
Like most other old Peanuts films brought to Blu-ray, the 1080p presentation of 'Snoopy Comes Home' features authentic animation with all its imperfections. Age and normal wear and tear are visible too, but expected. For the most part the image is strong.
Pencil lines and brush strokes are constantly visible. This provides a rough, but genuine look. Color fills sometimes vary in shade during the same scene. Pops and scratches are visible too, from time to time, but at least Warner Bros. didn't attempt to scrub every imperfection into non-existence. That would've created a waxy unwatchable movie. Instead, this transfer very much mirrors what we'd expect from animated source material from the '70s.
The Audio: Rating the Sound
Like 'A Boy Named Charlie Brown,' 'Snoopy Come Home' sports a DTS-HD Master Audio 5.1 mix that doesn't provide much in the surround sound department. I'm honestly not really sure why they decided to include more than a mono mix on these releases.
Most of the movie's sound is packed up front in the center channel. If the rear channels get anything it's some music from the songs and an echoing voice intoning "No Dogs Allowed," whenever Snoopy sees another sign, but that's about it. This movie just doesn't lend itself well to a surround sound track. It would've done just fine as a mono or stereo track.
HD Bonus Content: Any Exclusive Goodies in There?
There are no Blu-ray exclusives provided.
Technical Specs
- Blu-ray
All disc reviews at High-Def Digest are completed using the best consumer HD home theater products currently on the market. More
about our gear.
Puzzled by the technical jargon in our reviews, or wondering how we assess and rate HD DVD and Blu-ray discs? Learn about our review methodology.
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3DOcean rope fixtures 5393783
3DOcean rope fixtures 5393783
3D Model \ Vehicles \ Water \ Miscellaneous
Ship \ Fixture \ Files \ Model
3D Model - rope fixtures 5393783 by arx_f @ 3DOcean
3D Model \ Vehicles \ Water \ Miscellaneous
3D File Formats Included: .3ds (multi format), .c4d (cinema 4d), .dxf (multi format), .max (3ds Max), .obj (multi format); Animated: No; Created In: 3ds max 2012; Geometry: Polygons; Low-poly: Yes; Materials: Yes; Poly Count: 238; Rigged: No; Textured: Yes; UV Layout: Yes.
3D models of rope fixtures for your games/media productions. These are low polygonal models.
- poly count: 238
- Formats: Max /OBJ /fbx/3DS/DXF
- High detail was preserved with 2048×2048 textures
- 3 Maps included ( all in 2048×2048 ): diffuse +specular +normal
Freight Crane; Electric Generator; Ship's Fenders; Container Crane; Outpost Tower; Oil Pipes Set; Door Bulkhead.
Keywords: 3d model, dxf, fbx, files, fixture, max, obj, ship.
Download Link


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Bad Mood
The world is a stage and we are all actors upon it according to Shakespeare, and he's right. Seeing the world through this lens of 'playing a role' is revealing. When at work certain elements of our psyche get emphasized over others. Different elements are triggered when playing with children. Yet others when alone with a close friend. We can't help but play a different role. And what determines these roles are not so much ourselves as the environment we find ourselves in.
Like clockwork, I fall into a dark humor every time I drive home from work. I don't know exactly why, but I suspect it has everything to do with the transition between roles. At work I feel part of a team part; of something bigger than myself. I enjoy my relationship with coworkers. My work matters because it affects the ability of others to do their job.
On the drive home I'm hit with the realization that I could walk away from the job without any adverse effect on my personal life. I realize they would terminate me tomorrow if it made business sense. The knowledge leaves me feeling hollow, a sucker for caring, a 'tool', because that is precisely what I am to them, and to any employer for that matter. That's the alienating power of money and business.
The code though is its own reward. Painters paint, singers sing, I understand and manipulate machines. Whether it's software, a circuit, or an engine, the machine is my art. I've always been excited by the sight of a well-oiled machine doing its job efficiently, and disgusted by the sight of a living being doing the job of a machine. I truly believe that software and wisdom are the keys to fixing all the problems of our modern world.
I'm attracted to living and working from the boat because the role I play there is more in line with who I am; with who I want to be. My world relies on cantankerous machines instead of people. I'm in my element, and the only role I play is for myself. All the while, I am surrounded by the beauty of the islands and away from the stress of humans, traffic, noise, and money.
I got home on Thursday and couldn't wait to leave the dock. The rain and squall-induced, confused weather told me to leave in the morning. The weather that evening was as tempestuous as my mood. On top of my typical dark humor, I'm trapped in limbo waiting for the seller to officially accept my offer on the property. My future, the rest of my life, is floating in the breeze. And I have no idea how it's going to land.
I needed to restore my sense of balance. I needed to feel grounded.
I needed to go sailing.


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1 E LEXINGTON Avenue #903, Phoenix, Arizona
$369,0002 Beds2 BathsActive
$369,0002 Beds2 BathsActive
1 E LEXINGTON Avenue #903, Phoenix, Arizona 85012 - Location, views and luxury urban living all come together in one of Midtown's finest high rise condo communities; One Lexington. This CORNER unit on the south and east side of the 9th floor offers eye catching views. Upscale interior; appointed with granite, glass mosaic backsplash, European soft close cabinets and stainless appliances. Tile and high quality wood laminate flooring in all the right places. Nest thermostat. Freshly painted in 2015. Amenities include a resort style pool & spa, dog run, large gym and a community room with television and kitchen area. The building has secured entry, a concierge desk and parking garage. One Lexington is a adjacent to the Light Rail with easy access to many entertainment, sporting and dining venues.
Listing Courtesy of Contigo Realty
"No words that could ever convey my appreciation for your dedication to my child. Have spent the last three days moving the kids into their new home! We are all exhausted, but in a wonderful way. The first night Bela spent there he sent me a text that said "Out swimming in my own pool. Victory!" As parents I'm sure both of you can understand the joy that filled my heart with that text. The first house Bela's dad and I ever bought was 3 bdrm/1 bath/900sq ft/ and I raised three kids there!!! The "Bales" (as we call them) are starting out at almost 2400 sq feet with a mother in law suite and 3 other bedrooms and bathrooms! Crazy, but wonderful. There are just no words that could ever convey my appreciation for your dedication to my child. (and the crazy redhead)? Tired, exhausted, and sore, but loving you all the while. And I know I speak for everyone. Can't wait for the housewarming!!! YOU GUYS ROCK!!!!!"


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2016 Omega-3 Science Update
2016 Omega-3 Science Update
Omega-3 fatty acids from fish and other sources are fats with a uniquely diverse range of health applications. Boosting intake of these healthy fats—particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—through diet and supplementation can support the body in multiple ways.
For instance: aging results in lower neural concentrations of omega-3 fatty acids, leading to neuronal loss and a decline in cognitive function; however, recent studies show that omega-3 fats can enhance neuron signaling and synaptic plasticity, while preserving gray and white matter in the brain.1 Another example: inflammation is increasingly linked to chronic disease, but research shows that omega-3 fats play important roles in reducing inflammation by lowering the concentration of pro-inflammatory eicosanoids such as thromboxane B2 and leukotriene B4.2 And yet another example: studies show that omega-3 fatty acids may benefit arterial structure by reducing arterial stiffness and improving endothelial function, while simultaneously reducing oxidative stress and inflammation and favorably modifying the expression of enzymes involved in the process of atherosclerosis.3
The ability of omega-3 fatty acids to influence so many processes in the human body is what makes omega-3 research so exciting. Ahead, we highlight some of the most recently published human studies showing beneficial effects of supplementation with omega-3 fatty acids on several health conditions.
Reducing Heart Risk: Omega-3s Plus Vitamin B12
Given the role omega-3 fats play in heart health and vascular health, Tao Huang and colleagues from Zheijang University in China recently studied the effects of fish oil EPA and DHA on several risk factors of heart disease in healthy young adults.4 The researchers also had another objective: to evaluate possible synergistic effects of the omega-3 fatty acids and vitamin B12, a vitamin known to lower homocysteine levels (a risk factor for heart health).
In the eight-week randomized controlled trial, 30 subjects with a mean age of 23 were divided into three groups. One group supplemented with vitamin B12 (1,000 mcg/day). The second group supplemented with 2 g of fish oil daily (containing 490 mg DHA and 98 mg of EPA per gram). The third group was given a combination of both the fish oil and vitamin B12 supplements.
The researchers conducted blood tests to monitor the impact of supplementation on levels of plasma homocysteine, ferritin (a measure of iron status), triglycerides, uric acid, and C-reactive protein (a measure of inflammation). Measurements taken during the study at four and eight weeks showed that all groups experienced significant decreases in all measures. Plasma homocysteine concentration declined from baseline by 22% in the vitamin B12 group, by 19% in the fish oil group, and by 39% in the combination-supplement group. While each nutrient individually was able to significantly lower markers of heart risk, the fish oil and vitamin B12 combination had a substantial synergistic impact, indicating a powerful benefit for heart and vascular health.
Eye Health: Protecting Retinal Function
X-linked retinitis pigmentosa is a genetic condition affecting the retina of the eye that leads to progressive vision loss in boys and young men. In those with the condition, night blindness occurs initially with progressive constriction of the visual field, leading to blindness at an average age of 45. Where do omega-3 fatty acids come in? Science indicates that individuals with this condition have a reduced ability to synthesize the omega-3 fatty acid DHA from other fatty acids.5 For this reason, researchers believe that oral supplementation with DHA may help bypass this defect and potentially slow the progression of the disease.
In an earlier, 2014-published trial—the DHAX (DHA in X-linked Retinitis Pigmentosa) trial—researchers found no effect from DHA supplementation on slowing the loss of cone or rod function in males with retinitis pigmentosa6. Recently, however, those same researchers published a paper analyzing ancillary outcomes of the original trial. Specifically, they looked at the effects of DHA supplementation in those participants who completely adhered to the treatment protocol.7
This ancillary analysis included 49 males who were 7 to 31 years old. Of those subjects, 29 had received DHA (30 mg/kg body weight daily in the triglyceride form), while 22 received a placebo, for four years. Visual parameters were measured yearly, while DHA concentrations were assessed every six months.
The researchers found that red blood cell levels of DHA increased fourfold over placebo in those supplementing with DHA. While visual parameters like visual acuity, ability to discriminate shapes, or the appearance of the fundus of the eye were not significantly different between groups, the researchers did detect statistically significant benefits in favor of DHA supplementation for reducing the progression of dark adapted thresholds, a measure of night vision. Furthermore, DHA supplementation also helped to attenuate the decline in visual field sensitivity over the four-year period. This sensitivity was determined to be linked to red blood cell levels of DHA—that is, higher concentrations of DHA led to less of a decline.
These findings indicate that DHA supplementation can benefit certain parameters of retinal health and visual function in individuals with retinitis pigmentosa.
The researchers further advocated for additional studies using higher doses of DHA in order to try to induce greater benefits. Based on the DHA dose of 30 mg/kg body weight administered in the study, red blood cell DHA concentrations averaged 10.9%. By extrapolating the results comparing the mean red blood cell levels of DHA and loss of visual field sensitivity, the authors postulated that a red blood cell DHA concentration of 17% could fully attenuate the loss of visual field sensitivity. An estimated DHA dose to attain this level of red blood cell saturation would be 45 mg/kg body weight per day.7


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Product Description
Polycom VSX 7000 Details and Specification
- Polycom Siren 14 delivers crisp, crystal clear audio with an integrated speaker and subwoofer.
- Experience exceptionally real, smooth motion video for an extraordinary video conferencing experience.
- People+Content IP software (optional) requires only an IP network connection to show Content in a video call.
- Customisable user interface means you can configure the system that's right for your organization.
- Easy to setup and install with a minimal number of color coded cables.
- Set up and be making calls right away!
- SIP Support (Session Initiation Protocol)
- H.264 video and television-like Pro-Motion video for unsurpassed quality.
- 14 kHz wideband, crystal clear audio.
- Easy-to-use, customizable user interface.
- IP ready yet versatile enough to add QBRI, PRI or Serial network interface modules.
- Robust remote management tools for IT or video administrators.
- Advanced Encryption Standard (AES) support on ISDN and IP.
Additional Information
Polycom VSX 7000 Information
|Manufacturer Part #
|Light Grey


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Graffiti Design Abstract Spray 5 Art picture Canvas *
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Canvas Size: 24"x36" (60cm x 91cm) Frame Size : 24"x36"
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We aim to dispatch all items within 48hours of payment received, however some larger items and international orders may take longer.


text: I can look into that easily. My deliveries of oil are actually based on degree days and the data is posted. I will see if I have that data going far enough back. It is a good point too, as last year was so warm, I didn't even use the stove much at all while this year it is just constantly going.


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Getty this week made up to 35 million images free to use.
The new policy – which is likely to upset many photographers – applies to bloggers and social media users.
They will be able to display Getty photos – including famous shots of Marilyn Monroe and John F. Kennedy – on their websites via an embed tool.
Anyone can use #GettyImages stock photos for free now! Bloggers & website owners worldwide rejoice! http://t.co/DUgxJgtUML
— Sally Press (@PS_SallyP) March 6, 2014
They won't have to pay a cent for the licensing fee or worry about receiving a threatening letter from an intellectual property rights lawyer.
Commercial organizations, such as media outlets, will still have to pay for the right to use the photos.
Getty has been fighting a losing battle against the illegal use of its images.
"Our content was everywhere already," said Craig Peters, a senior vice president of business development, who likened the situation faced by Getty to that of the music industry during the pre-iTunes era of the 1990s when content was being shared without attribution or payment.
"If you want to get a Getty image today, you can find it without a watermark very simply.
"The way you do that is you go to one of our customer sites and you right-click. Or you go to Google Image search or Bing Image Search and you get it there. And that's what's happening…"
Now Getty is trying to turn this illegal behavior into an opportunity to make money.
"What we're trying to do is take a behavior that already exists and enable it legally, then try to get some benefits back to the photographer primarily through attribution and linkage," Peters said.
Previously, all images displayed on Getty's website came with a watermark and users wanting the photo without the transparent placard had to pay for it.
That's not the case anymore. A large number of images will be framed with an embed code that attaches a credit and link back to Getty's website where the user can get more information about the image or photographer.
It's based on the same system that lets you embed tweets or YouTube videos.
Getty's new embed tool.Screengrab
While the move seems counter intuitive given Getty makes money from selling permission to use photos from its vast library of images, there is method in its madness.
The Verge explains: "The new money comes because, once the images are embedded, Getty has much more control over the images.
"The new embeds are built on the same iframe code that lets you embed a tweet or a YouTube video, which means the company can use embeds to plant ads or collect user information."
While Getty's announcement is great news for bloggers, photographers will probably have a different view.
"I do anticipate a great many photographers being unhappy if not that their images can be licensed for free in non-commercial contexts, but that they don't have the opportunity to decide how their images can and cannot be used," Daniela Bowker, editor of photography website Photocritic.


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Britain's rarest butterflies face extinction
Five of Britain's rarest butterflies are facing increased risk of extinction due to the washout summers of the last three years, a fresh study found.
In a study of more than 1,000 sites, researchers found that 2009 proved to be the worst year for Britain's two rarest species viz. the Duke of Burgundy and Lulworth skipper.
Other rare species, including the wood white, the high-brown fritillary and pearl-bordered fritillary, have also suffered steep fall over the last three years.
It should be noted here that heavy rain makes it difficult for butterflies to fly. After wet summers of 2007 and 2008, previous year's wet July and August affected butterflies adversely.
Speaking on the topic, Butterfly Conservation's CEO Martin Warren said, "We've had this run of poor summers which have knocked these species down even further and they've got very little resilience to bounce back."
Experts have warned that if the number of butterflies is declining then other wildlife will also be in falling.