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Olixar Extreme Protection Galaxy S8 Case & Glass Screen Protector
Royal Mail Economy: £1.99
Aims to deliver within 3-5 working days including Saturdays.
Hermes Tracked First Class: £3.99
Hermes is a fully tracked service, which which aims to deliver the next working day* including Saturdays.
DPD Next Working Day Parcel: £6.99
DPD Next Working Day Parcel guarantees next working day delivery* and provides a comprehensive tracking system, including a live driver tracker and a 1 hour delivery window.
DHL Global Mail: £3.50
A low cost and reliable international posting service, which is untracked and aims to deliver between 4-8 working days.
DHL International Air Express: From £9.95
A fast, secure and reliable worldwide delivery with priority handling and a full on-line tracking facility. Usually takes between 1-3 working days.
*Order by 6pm for same working day dispatch, except DHL International required by 5pm
30-Day Money Back Guarantee
At Mobile Fun, we wish to ensure you are happy with your item(s), so we offer a fantastic 30-day money back guarantee for your peace of mind*
*To find out more, please visit our Terms and Conditions page to learn all about our returns policy.
|Price match promise
|UK based customer services team
|Sign up for a Business Account
Most Helpful Reviews
192452Easy to order online, no hassle, will order again definitely.
Anonymous 26th August 2017
So far the Cover and Glass work fine148141So far the Cover and Glass work fine. Both fit perfectly with each other. Also the Glass works fine, very responsive.
Glass -
One of the few dislikes are; it comes with a glue sticker and doesnt cover all of the curved screen.
Cover -
Pretty rugged but the card slot is a bit loose. And the kick stand is a bit flimsy. But overall the whole package isnt that bad at all.
Billy J SAMSUNG S8 Valletta, Malta 14th June 2017
Really good protector and case148216When arrived was pleasantly surprised. The protector was easy to apply but read the instructions and you cannot go wrong The case is brilliant sturdy and fits perfectly snug.Best ive used yet.
Philip Brookman Olixar Extreme Protection Galaxy S8 Case & Glass Screen Protector Medway 13th June 2017
- See All Reviews
Why Buy?
- Rugged all round protection for your Galaxy S8
- Enhanced drop protection
- Secure quick access compartment for card storage
- Built-in kickstand
- Access to all ports and featuresCase compatible protection for your S8's screen
- High-tension 9H tempered glass construction for enhanced shock protection
- Prevents screen scratching and other damage
- Curved protector to cover even the sides of your display
- Optimal clarity barely able to notice it is there
- Easy to apply
Own a Samsung Galaxy S8? Do you want to give it 360 degree protection - including the screen? Then why not pull out all the stops and get the Extreme Protection Pack?
The Olixar Extreme Protection Pack features a X-Trex rugged card case and a compatible tempered glass curved screen protector. This creates the ultimate way to keep your Galaxy S8 looking as good as new for as long as you'll have it.
The 'Extreme Protection' pack includes:
- Olixar X-Trex Samsung Galaxy S8 Rugged Card Case - Black
- Olixar Galaxy S8 Case Compatible Glass Screen Protector - Black
First, let's look at the case in more detail
Rugged all round protection for your Galaxy S8
Featuring a robust multi-layered design, the Olixar X-Trex provides excellent protection for your Galaxy S8 and just might be the best all-round travel case available. This hard-wearing tough case safe-guards your phone against whatever life can throw at it, keeping it secure at all times - even in the most extreme of conditions. With rubberised non-slip bumper pads, textured surfaces for extra grip, a secure card compartment and a handy flip out kickstand, few other cases come close to the protection and features on offer here. The X-Trex is suitable for commuting, outdoor travel and everyday use in equal measure.
Enhanced drop protection
First and foremost, the X-Trex is designed to protect the Samsung Galaxy S8 and protect it does, with some aplomb. Composite layers of shock-absorbing thermopolyurethane and ultra-resistant reinforced polycarbonate take all the punishment your daily travel and use can throw at your phone, including drop protection. The front facing lip is raised above the level of the screen, meaning it will keep your screen off flat surfaces so it doesn't get scuffed or dirty. Reinforced corners are designed to deflect shock force away from your phone and the corners are the most vulnerable areas of any phone or case. Likewise, the phone's vulnerable buttons are catered for with generous and fully functional covers.
Secure quick access compartment for card storage
The Olixar X-Trex case features an ingenious back compartment that can hold up to 2 credit cards or IDs. This is a secure and ingenious way of storing your most vital cards and also means you can leave your wallet at home if you want to.
Built-in kickstand
Located at the back of the case is a super-convenient flip-out kickstand. Folding completely flat when not in use, the kickstand can be called upon at will, allowing you to effortlessly watch media at any time and in any place in both landscape and portrait. It's stable enough to use anywhere.
Next, let's look at the incredible screen protector:
Case compatible protection for your S8's screen
This ingenious solution to protecting your S8's screen involves a tempered glass protector that covers most of the the edges of the curved screen, allowing you to use most cases on the market with it too. The underside of the screen protector sits flat on the screen and follows the contours of your phone's screen perfectly. This covers the entire screen and offers complete protection. No more compromising by leaving the curved edges exposed and this also ensures no dirt will get in - so no more "halo effect". By allowing you to use a case, you can have the complete protective solution for your phone.
High-tension 9H tempered glass construction for enhanced shock protection
The Olixar tempered glass case compatible screen protector is made from a reinforced tempered glass with an impressive 9H rating, maintaining image clarity while protecting your phone's screen from scratches and external shock. Using glass, the Olixar tempered glass screen protector with its impressive surface hardness and 0.3mm thickness is ready for your daily routine - taking care of your phone's display and maintaining its superb visual qualities.
Prevents screen scratching and other damage
The Olixar range of screen protectors are designed to keep your Galaxy S8's screen clear from scratches and scrapes that could hamper your visibility. By creating a tough barrier between your screen and the world, any damage will be done to the screen protector and not the phone, keeping your device looking good as new.
Curved protector to cover even the sides of your display
The Samsung Galaxy S8 features a unique curved edge screen, perfect for viewing notifications on either side of the phone. The Olixar Tempered Glass Curved Screen Protector is designed to cover even these areas of the screen, so you can rest assured your Galaxy S8 has 100% display coverage providing all round protection.
Optimal clarity barely able to notice it is there
While it's important to protect your screen, it's also vital that the screen protector does not hinder your smartphone use by clouding the screen or noticeable decreasing the sensitivity of the touchscreen. Olixar screen protectors are specially made to provide optimal clarity, while also being thin enough to keep your touchscreen in perfect working order. Once on, you will find it hard to even notice the Olixar screen protector is there.
Easy to apply
Olixar screen protectors are easy to apply, as they are custom cut for each device. Simply clean the screen with the included microfibre cloth, line up the screen protector with your phone and apply. Once on, the screen protector is practically invisible.
Key Details
Questions & Answers
Delivery & Returns
Delivery options
Royal Mail Economy: £1.99
Royal Mail's reliable economy postal service aims to deliver within 3- 5 working days including Saturdays but may take longer. We guarantee to dispatch in-stock items on the same day (Monday to Friday) if you order before 6pm.*
*Please note orders for batteries and power banks may be subject to delays due to dangerous goods shipping requirements.
Hermes Tracked First Class: £3.99
Hermes is a fully tracked service which which aims to deliver the next working day including Saturdays but may take longer. Order by 6pm for same working day dispatch.*
*Please note orders for batteries and power banks may be subject to delays due to dangerous goods shipping requirements.
DPD Next Day Parcel: £6.99
DPD Next Day Parcel guarantees next working day delivery and will take two days for the Northern Highlands, Northern Ireland and other distant areas. For DPD deliveries, we guarantee to dispatch in-stock items on the same day (Monday to Friday) if you order before 6pm.*
provides a comprehensive tracking system, including a live driver tracker and a 1 hour delivery window. *Delivery
*Please note orders for batteries and power banks may be subject to delays due to dangerous goods shipping requirements.
DHL Global Mail: £3.50
A low cost, reliable international posting service, suitable for your less urgent orders. This service is untracked and is usually delivered in 4-8 working days.
DHL International Air Express: From £9.95
Order before 6pm UK time for a fast, secure and reliable worldwide delivery. Your item will receive priority handling, and benefit from a full on-line tracking facility so you can check your mail's progress along the way. Usually takes 1-3 working days.
- Fast, same-day despatch when you order by 6pm on weekdays
- Free no-quibble 30 day return policy
- One flat delivery price for your order, no matter how many items you buy.
- For partially in-stock orders you pay for delivery only once. We'll ship what's in stock now and the rest later at no extra charge.
*Please note orders for batteries and power banks may be subject to delays due to dangerous goods shipping requirements.
Delivery information
You can view all of our delivery options, covering UK and international shipping by visiting our Delivery Information page.
Returns information
Buy with confidence. Our 30 Day Money Back Guarantee means you can return your item in exchange for a full refund or exchange.
For more information about Shipping, Handling and Returns, please see our Terms & Conditions.


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This product is no longer available from DriveThruRPG.com
All of Shaman's Stock Art offerings are excellent quality. Great color and high resolution.
The best full color stock art product lines selling on the PDF market today, and I am even comparing it to my own Image Portfolio series. You can go wrong with Shaman's Stockart series. All of them are great!

subset: commoncrawl


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Results 1 to 3 of 3
August 16th, 2003, 10:34 AM #1
- Join Date
- January 18th, 2005
- Posts
- 1,133
It seems that linkshare is processing click-throughs at an EXTREMELY slow rate this weekend thus far while the rest of our links are going along well.
Anyone else notice this?
August 16th, 2003, 11:59 AM #2
- Join Date
- January 18th, 2005
- Posts
- 2,082
Yes I noticed it when I was updating links. It was slower than molasses. It seems to be going a little faster now.
Join the Fight! Parasite Free In 2003!
August 16th, 2003, 04:10 PM #3
- Join Date
- January 17th, 2005
- Posts
- 352
If someone can send me an example of the problem I can have someone look into it. All our systems have been unaffected by the blackout so without and example I have no idea what you observed might be.
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a bot designed to manage and look after the arcemu wow server
written in tcl for eggdrop
requires mysql for tcl
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Network slow, but you don't know the cause? Use Bandwidth Analyzer Pack (BAP) to monitor and analyze network bandwidth performance and traffic patterns. With BAP, you can identify which users, applications, and protocols are consuming the most bandwidth. You can also monitor Wireless LAN Controller traffic to see what applications and clients are using your wireless network. Try it free for 30 days!
User Reviews
Be the first to post a review of ArcEmu Wow Server Bot tcl script!


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Radioactive waste consultation hits rocky ground
The Government's Committee on Radioactive Waste Management has proposed a shortlist of options to manage the UK's radioactive waste - but is facing internal disputes and is under fire for the time it has taken to reach this stage. Meanwhile, the Government has announced a separate consultation on dealing with low level radioactive waste.
Sorry you do not have access to this article. Please contact Customer Support at
or call 020 8267 8120


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Instagram: Easy to use
With the improvements in technology, a lot of people have shifted to social media markets for the buying and selling of products rather than the old traditional markets, since these online markets are easily available, time-saving, and more attractive and also save the customers the trouble and cost of travel.
Facebook, Twitter, Tumblr, Pinterest, Instagram are the new contemporary markets and they are leaving no stone unturned in the vast world of marketing. Creating markets out of thin air has become so much more effortless because of these websites and Instagram is the most accessible and uncomplicated amongst all of them. Instagram marketing involves straightforward advertising, through pictures and short videos, with small captions and details.
Reasons Why It Is Hugely Adopted
Followers are the most crucial bit of marketing on Instagram. The amount of followers a profile has, determines its reputation, and its creditability. But, with growing acclamation of the application, even small business units have been able to expand their business beyond just the local reach. A lot of people have quoted that Instagram is one photo app that can make even the ugliest pictures look beautiful.
Instagram has an acceptable range of photo filters that make the image more attractive. Other features of Instagram are quite basic, and easy. So what is it that has made a large number of people, including first class brands and most common of all common people adopt this social media so dearly?
- Instagram allows the person or the brand to follow back and respond to the customers with ease.
- On Instagram, using the hashtags to conduct contests and giveaways brings about interest and active participation from followers.
- A lot of business houses and companies often click pictures of their fans and customers and upload them on Instagram. This helps the brand publicity and also gets it happy customers that would look forward to look out for more updates from the brand.
- Making an Instagram page a little personal has helped a lot of labels. By posting behind the scenes, and pictures from the individual's personal life, one can connect with the followers better and let them live through his posts.
- Instagram allows people to know what their friends and the people they follow have been tracking. Hence allowing awareness about new brands and low-end profiles.
- Instagram grants the feature of GeoTagging to its users by which people can look up the location of stores and brands using the image uploaded.
The above mentioned reasons are what have made Instagram a bright, leading and easily adaptable marketing strategy among not business units, vast and small, alike.
Instagram followers buy goodies based on the quality of the pictures and on the basis of the networking skills of the brand. Buy followers has been observed that most used prefer to buy products that are shown in an enviable fashion on the application. So, no matter if the brand is expanded or small, the proper use of the app can make it successful.


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Quick response and careful timing by El Dorado Hills firefighters prevented an attic fire at 630 Powers Drive from spreading into the house early Tuesday morning. Firefighters vented the oxygen-starved fire from three places simultaneously, directing a 30-foot fire ball into the night sky.
"They timed it just right," said interim Fire Chief Jim O'Camb of the brief but dramatic pyrotechnic display on March 1. "If they don't, all that fire, water and smoke blows back into the house."
Firefighters let the fire suck water into the attic from the ceiling vent. It was extinguished within minutes.
The resident heard a suspicious crackling noise in the attic shortly after midnight Tuesday, and had his wife and daughter up by the time the smoke alarm went off, O'Camb said.
El Dorado Hills firefighters got the call at 12:18 a.m. Battalion Chief Antonio Morino arrived three minutes later with Engine 85 on his heels. He found the family in the lawn and "charged" smoke spewing out of the attic vents, according to O'Camb.
The cause of the fire is still being investigated but, O'Camb said, aging wiring in the attic was a likely culprit.
The house's original shake roof had been replaced with a new, fire retardant composition roof, on top of the original 1×4 'skip sheeting' underlayment, which provided the primary fuel for the blaze.
"They laid down foil clad plywood on top of the old underlayment," he said, adding that the foil contained the heat and hastened the spread of the fire into both first- and second-floor sections of the attic.
The quick response kept the fire contained to the attic, with almost no sign of smoke in the house, O'Camb continued.
Engineer Brenton Warren suffered second-degree burns when the fire "flashed" through the attic vent he'd just pried open. He was treated at the scene and did not require hospitalization.
Within three minutes of the "flash" the fire was all but out, having sucked the wet air throughout the attic, said O'Camb. The roof structure suffered extensive damage but the interior and furniture survived the fire relatively unscathed, he added.
The name of the family was not available at press time. O'Camb said they are staying with relatives in Folsom. The family cat was at large as of last Wednesday.
Damp conditions prevented any threat to neighboring homes, said O'Camb. Engine companies from Folsom and Cameron Park turned out to help with the mop up.


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Massey Cadillac Dallas Body Shop
Featured Business
Park Place Bodywerks Auto Body and Collision Repair Center6120 Peeler St.
Dallas, TX 75235
9.4 miles away
"Joyce said her visit to this business was a good experience."
Review for Massey Cadillac Dallas Body Shop
Dawn M. on 09/05/2012
Dawn said she always uses this business. She said the work was horrible because the trunk was a disaster and the rear wheel cover was not fastened. She said the business told her the work would be done in five days. She called the business to ask what was going on and they told her it would take another week to fix the vehicle. She said her mobile phone charger was stolen while her vehicle was at the business. She told the business and an employee told her to bring her receipt and that they would reimburse her. The employee told her they would send the reimbursement by mail within a week and it has now been three weeks. She said the two employees that took her vehicle in do not currently work at the business now. She would not recommend the business to others based on this experience.
Category: Collision
Service Date: 08/30/2012
Review Created: 09/05/2012
This review was collected via phone interview by Customer Research Inc.


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All things fleet tracking – industry news and best practices
GPS Fleet Tracking: Right for Your Business?
Posted on 06/27/2012 by Ashley Jones | 0 Comments
Selecting the right GPS fleet tracking solution for your business is not an easy decision or one to take lightly. With an increase in the number of solutions available in the marketplace, finding your way through the considerable amount of choices can seem like a daunting challenge.
The features and benefits of each solution can and should differ depending or your company's needs. A GPS vehicle tracking solution is not a "one size fits all" solution. The needs of a small to medium-sized businesses vary greatly compared to a large enterprise organization's needs. Finding the right system for your business requires careful research of available options and solutions.
To start, take a moment and consider your daily operations. Are you a small HVAC company that makes service calls to residential locations within a small metro area? Or, are you a national food and beverage company that needs to track its vehicles while ensuring the freshness of your cargo? Download our free white paper to find out what is right for you or look at our packages based on functionality.
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Tank Tops - MensSave on Men's Tank Tops at Proboardshop.com! Great selection of street gear at unbelievably low prices. Proboardshop has been selling Tank Tops and outdoor gear for over 30 years and we're proud of it.
Please refine here More in the Outlet Shop.
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Thursday, October 4, 2007
Stuck Between the Seasons
It's humid, but dry, uncomfortable. Leaves are dropping, all dried up and crumbly. Once they hit the pavements, they're quickly ground into leaf dust by the feet of passersby. Everything looks brown, shrivelled.
What I remember about October days in years past is the crisp air, blue skies, chilly rains, vivid colors. Is this a faulty memory? What gives?
It feels like autumn is trying, but not succeeding, in its attempts to seduce the midatlantic landscape. But the days are growing shorter; it's only a matter of time. I want to say to the weather gods, let go!! Please, let go!!
That's the message I've been giving myself the last the few days, too, isn't it? Hmmmmmmm....
9 comments:
- Momentary Academic said...
October needs to be here. Not this kind of October, but that kind. The one that you describe.
Dearest Reya,
We need to meet soon.
- October 4, 2007 at 4:55 PM
- Pod said...
see, even the weather gods hang on a bit too. don't worry, i don't think you are losing your marbles. well maybe just one. a green and blue swirly one
have a great weekend
- October 5, 2007 at 7:36 AM
- Lynne said...
I'm with you:
Summer, be gone! Let go and give way to Autumn, please!!
- October 5, 2007 at 7:53 AM
- Reya Mellicker said...
Thank you, Pod.
And LYnne and M.A. - please put in a word to the weather gods, would you? I've been shaking a fist at the sky, threatening them that if they don't bring rain and colder temperatures, I'll ... I'll .....
They just laugh in my face.
- October 5, 2007 at 7:59 AM
- mysticalfeet said...
Since I have few warm clothes and am spending time outside, I'm enjoying the warmth, but damn, is it ever dry! SO lovely to see you the other day. The Gold Puppy is nice, and with a definitely different flavor than the former incarnation.
- October 5, 2007 at 9:24 AM
- Barbara said...
What worries me most is the large number of trees whose leaves are turning because they are dead. There are always a few summer casualties, but this year resulted in an awful lot of dead trees in the DC area.
It definitely feels like Fall here in Chautauqua. I'm sitting on the porch with my sweatshirt on trying to decide how to spend this glorious Fall day.
I'll send you thoughts of healthy colored leaves and crisp Fall days!
- October 5, 2007 at 9:37 AM
- IntangibleArts said...
Firstly: Good to have you back in the world of blogorifficness!
Secondly: I couldn't agree more. After a brief tease of cool comfort, this wretched backlash into swampy summer?
Not fair. I demand a refund.
- October 5, 2007 at 10:31 AM
- Steve said...
We keep getting little bursts of fall, a couple of cool nights, some crisp weather -- and then back to humidity. October can be just as temperamental as March!
- October 5, 2007 at 12:06 PM
- lettuce said...
yes, our autumn can't quite make its mind up either. it does complicate the transitions, doesn't it?
wishing you a bit of nippiness.
- October 6, 2007 at 6:00 AM


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Manhole Frame & Cover(Circular of 30 Medium Duty)
In stock
Reconfirm the price with seller
Products of other enterprises
Technical characteristics
- BrandMedium
- MaterialPlastics
We are one of the well known Suppliers of Manhole Frames & Covers in the market. These are available in various sizes and diameters and as per the client's requirement. We offer the superior quality Manhole Frames and Covers to the customer. These Manhole Frames and covers fulfill the necessities of different Public and Private projects which are used to cover the drains and drainage.
Available In :
Used For :
Attributes :
- Robust construction
- Cost effective
- Durable
Available In :
- Wide range
Used For :
- Domestic and Industrial purposes
Contact the seller
Manhole Frame & Cover(Circular of 30 Medium Duty)
View also products categories "Well hatches"


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GraphicRiver Ecofusion 11877904
Category: Logo Template | Comment: ( 0 )
GraphicRiver Ecofusion 11877904
Logo Template \ Nature
Leaf \ Leaves \ Insurance \ Herbal \ Healing \ Health \ Life \ Medical \ Restaurant
Logo Template - Ecofusion 11877904 by danoeadjie @ GraphicRiver
Logo Template \ Nature
Layered: Yes; Graphics Files Included: Vector EPS, AI Illustrator; Resolution: Resizable; Minimum Adobe CS Version: CS.
ecofusion is a perfect logo for any business & products related to Nature, Green Energy, Health Care, Medical, Food, Restaurant, Media, Research, Marketing, Accountant, Organization, etc.
The Package will include.
- AI Files
- EPS 10 Files
- PDF Files
- ReadMe files (Guide & Link to download the font used)
*Mockup are for preview purpose only! *
It would be really appreciated if you could rate my item
Shamrock; Business Boat; Corat Caroot; Colorful Spaces; Strong Research; Hexo Papers; Green Shop.
Keywords: abstract, brand, business, company, consulting, corporate, earth, eco, element, energy, finance, fitness, food, garden, green, grow, healing, health, herbal, insurance, leaf, leaves, life, medical, nature, organic, power, restaurant, spa.
Download Link


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Toyota of Puyallup
Review for Toyota of Puyallup
BARBARA G. on 07/01/2015
"Outstanding service! Great to work with!"
I was very happy with my salesperson, Sipha Vong, and the entire team. They were very helpful, and I am pleased with my purchase.
Vehicle: TOYOTA PRIUS
Category: Sales
Sales Date: 06/30/2015
Review Created: 07/01/2015 02:53 PM
Kerry S., President & General Manager at Toyota of Puyallup responded on 07/01/2015
Thank you for the 5 star review, Barbara. We truly value your business, and it is wonderful to hear that you had such a great buying experience. Congrats on your new Prius!
President & General Manager
Toyota of Puyallup


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Dittrich's Auto Clinic
Review for Dittrich's Auto Clinic
Tony H. on 01/10/2015
Tony said he has never had a problem with Keith. He is a great guy and he does great work. They are very prompt with getting the vehicle out right away.
Vehicle: Toyota Sequoia
Category: Service
Service Date: 01/07/2015
Review Created: 01/10/2015
This review was collected via phone interview by Customer Research Inc.


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Ms Morgan was relentlessly pursued by a work colleague Anthony Burstow from 1992 until his imprisonment nearly 10 years later.
Burstow broke into her home and car and placed listening devices in her bed and at her office at work to allow him to learn about Ms Morgan and her movements.
The stress led to the collapse of her marriage and she sought counselling for post-traumatic stress. Burstow was jailed for life for the attempted murder of another woman in 2001
Ms Morgan has campaigned for better protection for victims which helped result in the Protection from Harassment Act 1997.
An all-party Parliamentary group has said today that the existing law against harassment is not fit for purpose, leading to light sentences in the few cases where prosecutions are brought.
Ms Morgan hopes now a specific offence of stalking will me made into law.
"Basically it was mental rape on a daily basis," she said.
"Victims of stalking don't know if they are going to die today. You are living on the edge, not knowing what is going to happen to you."


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Plug-In 25-1/2 To 29-1/2 Adjustable Height 2-3/8 Power Rise Tan Pro Seat - Springfield
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This item is found in the following Product Families
Control Post
From a completely flat position to 90 degrees upright, the Control Post adjusts in every direction for complete comfort during even the longest days on the water. The innovative ball mount gives unmatched adjustability. Simply loosen the knob on the rear of the mount and position the cushioned seat to your desire comfort: - upright for enhanced lower back support - angled to take pressure off your legs.
- Power-Rise Stand-Up Pedestal With Up/Down Lever
- Adjustable Height From 25-1/2″ To 29-1/2″
- Mica Tan Pro Seat
- Rotates With Your Changing Cast Angles
ABYC Class B - Seat designed for occupancy only at boat speeds not exceeding five miles per hour.
Springfield Marine Seat Pedestals have a 5 year warranty.
Can this seat on this post be removed?
How long is tis price good for?
It is good until at least the end of the month, April 2016.
What is your return policy if this does not fit the receptacles in my boat?
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Congratulations to @laurence_ce on winning the #DeepSummer Photo Challenge Viewers Choice Award @whistlerblackcomb! "The wildlife and nature surrounding Whistler is just amazing. Glazier capped mountains, lagoon coloured lakes and beautiful bird life....


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Kritter Kondo - Deluxe Pink
It's like an outdoor playpen for indoor pets. Because pets need sun AND shade! Spoil your pet in this fabulous PINK Kritter Kondo Deluxe. Pink frame, pink netting, pink shade canopy, pink purrrrrs and wags. The Kritter Kondo Deluxe PINK is an outdoor pet enclosure ideal for indoor cats and small dogs. The Kritter Kondo Deluxe collapses flat with the simple release of a few pins; no assembly required. A shade canopy is built in to offer a shady side and a sunny side for your pet to enjoy. The Kondo comes with it's own carrying case which has a shoulder strap and handles for easy mobility and storage. The interior of the carrying case has three pockets and a zipper pouch for toys, food, blanket and bed. Features: Collapsible pet enclosure Outdoor safe and water-resistant Collapsible shade canopy (attached to Kondo) One-piece construction - no stakes and very minimal assembly Lightweight and mobile Removable double french doors Door on either end for easy access to pet Great for cats and dogs 35lbs and less too Ideal for patios, yards, courtyards and balconies Includes carrying case Set-Up Dimensions: 2' H x 2.5' W x 6' L Do not leave your pets outdoors unattended.
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auto cad work
Presupuesto ₹12500-37500 INR
I am looking for a freelancer to help me with my project. The skills required are AutoCAD, CAD/CAM, CATIA, Google SketchUp and Solidworks. I am happy to pay a fixed priced and my budget is ₹12500 - ₹37500 INR. I have not provided a detailed description and have not uploaded any files.
68 los freelancers están ofertando un promedio de ₹23122 para este trabajo.
Hi, I am professional 2D & 3D CAD designer with 5 years of experience in product designing & hardcore mechanical engineering designing. I will do this work in genuine price with supreme quality. Please see my portfol Más
Good day. Please tell me about the details so I can give you the right quote. Can give you the best product abd the lowest price possible.
I am an architect with 6 years of experience in the fields of residential, cultural, educational, commercial, offices and interior design .I am an expert in programs such as AutoCad, 3D Studio Max, Sketchup and Photo Más
Hello! I am a civil engineer with experience in the preparation of drawings with AutoCAD, SketchUp and Sweet Home for 2D and 3D designs. I would like to work on your project! I have the skills to meet the! Do not he Más
I develop products (a 3D detail and drawings) in the program SolidWorks, Inventor, AutoCAD. I have wide experience in production of details.
Good working experience in Solid modelling/surfacing/assembly and drafting using Pro-E wildfire4.0 with advance surfacing and Creo(Pro-E),SOLIDWORKS,CATIA,UNIGRAPHICS,AUTOCAD- 8 years Good knowledge on Plastic and Alu Más
quality assurance and efficiency. I work with a team which will assist in checking the work to ensure that drawing is to required standard.
I have professional experience of working on online jobs as I am currently working for my employer in UK. He sends me the pdf works and I make detailed design using AutoCAD (sometimes SolidWorks and CATIA too) and send Más
Hi, I am a Civil Engineer and good at in Auto CAD, please provide me an opportunity. Regards, Usha.A
hard work and better understanding. also understanding of software is good as well as can interpret between need and machine language.
The thing which makes me the best candidate is that I am into it because I love designing and I hope to get something new from you and changeling which can help me in my career.


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Hawks Edge Blazers in OT
Joe Johnson scored eight of his game-high 35 points in overtime as his Atlanta Hawks went on to outlast the Portland Trail Blazers 99-95 last night at Philips Arena. The Hawks have started off the year red hot with regular season record of 9-2. The team believes themselves to be definite contenders in the East for 2010.
"The last two years being in the playoffs has put this team in a totally different light," said coach Mike Woodson. "Now when they go on the court, they know they have a chance to win. It's kind of nice sitting on the top of the division." Josh Smith collected 20 points and 16 rebounds to help Atlanta earn their fifth consecutive victory, a streak that includes a tough road win in Boston against the Celtics.
The Trail Blazers have also improved immensely over the years. So far this season they hold an 8-4 record with young talent LaMarcus Aldridge, Andre Miller, and Greg Oden leading the way. Aldridge notched 18 yesterday with Miller and Oden following up with 14 and 11, respectively. Portland is set to host the Detroit Pistons Wednesday as the Hawks take on the Miami Heat in Atlanta.
Categories: Atlanta Events, Atlanta Hawks, NBA Basketball, Portland Trail Blazers, Sports


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- — HOW-TO: Make Windows 7 Boot Faster
- — TWEAK: Filter Unread Emails in Gmail
- — TIP: Linux Virtual Machine Performance Tweaks
- — HOW-TO: Automated TV Series Downloads Using Raspberry-PI
- — FAQ: Mouse Randomly Freezing in Windows 7
- — TWEAK: Make Torrents Download Faster
REVIEW: WD Caviar Black 1TB WD1001FALS SATA II Drive
A few years back, having a hard drive that boasts 250GB of capacity is the bomb. To conform to uber standards computers need to have hundreds of gigabytes of storage. Nowadays the mention of gigabytes is a common thing, nothing out of the ordinary. Gigabyte is out.. Terabyte is in.
What we have for review is the Western Digital Caviar Black 1TB WD1001FALS desktop hard drive. It has a generous 32MB of cache which, as you may notice, is becoming quite common to desktop drives as well. How does this drive perform? Please allow us to share our experience.
In our review of the Seagate ST3640323AS 640GB, we found out that the cache and platter areal density contributes or influences the overall performance of the drive. The WD1001FALS has three (3) 334GB platters that allows the drive to reach the terabyte mark. Up 14GB from the quick Caviar SE16 product line.
The drive also features WD's StableTrac which according to the Western Digital website is:
StableTrac - The motor shaft is secured at both ends to reduce system-induced vibration and stabilize platters for accurate tracking, during read and write operations.
The WD1001FALS also has a dual processor system to maximize performance. See below how it performs under HD Tune.
It is good to see drives hitting average transfer rates above 100MB/s. The WD Caviar Black 1TB WD1001FALS goes over the watermark with ease, averaging close to 110MB/s. Judging from the graph, its performance is almost uniform from the beginning of the disk to the outer end.
The drive is also quite quick, which is apparent from the lower access times in the benchmark.
And one of the many aspects common to all desktop drives now is the lengthy five (5) year warranty. It seems every hard drive manufacturer is ever growing confident with the quality of their hard drives. True enough in the last few years I have experienced DOA drives but I have yet to experienced a drive give out mid-life. DOA means manufacturing or transport induced defects. On the other hand mid-life death is more likely due to wear and is expensive -- both to the end-user and to the manufacturer.
With desktop grade drives offering fast transfer speeds, healthy amounts of cache and about the same five-year warranty the aspect that would separate each from its competitors is its price. But in the Philippines the WD1001FALS sells for about PHP 1000 more than its 1TB competitors.
There must be something in the drive that warrants a price premium but it still stands as a puzzle to us what that is. If you think paying about $20 more for the same size, then go for it.
As said in the beginning of this review, gigabyte is out terabyte is in. The WD Caviar Black 1TB WD1001FALS has just that, and it will definitely pimp your rig!
Acknowledgments to my good friend Xavier Zulueta for the review of the WD1001FALS.
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Published: May 13, 2013
Ella Perry, 6, of New Middletown shows her quarter pony Missy in the halter open class during the Penn-Ohio Horseman's Association Double Point Open Horse Show on Sunday at the Canfield Fairgrounds. Ella and Missy took first place in the class.
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Proudly Nigerian Blog...Entertainment,Lifestyle,Fashion News on The Go.
Monday, 30 November 2015
Schoolgirl commits suicide after becoming allergic to Wifi(Photo)
Jenny Fry was left with crippling headaches, tiredness and bladder problems brought on by electro-hypersensitivity (EHS).The 15-year-old's mum Debra said her symptoms were caused because she was allergic to wireless internet connections at her school.
Earlier in the day she had texted a friend telling her she was not going to school that day.
Although they had taken the WiFi out of their own home, it was still used in Chipping Norton School, Oxon., where she was a pupil.
Mrs Fry said:
Ready to pop? Kim Kardashian shows off her 37 week old baby bump
Ini Edo shows off hot legs
Be careful with hampers this Christmas – Police warn Nigerians
Nigerians have been warned to be careful with hampers this Christmas season.The security alert was issued by the Inspector General of Police, Solomon Arase, on Monday,cautioning Nigerians to be extra alert while receiving gifts during the Yuletide season so as to avoid receiving explosive-laden hampers as gifts.In a statement signed by the Force Spokesperson, Acting, ACP Olabisi Kolawole, Arase warned against the use of fireworks such as "bangers" and other explosives as they could further heighten the fear of insecurity during the festive season.
The statement said,
(Photos)President Buhari addresses the UN Climate Change Conference in Paris
Today ,President Buhari who is in Paris for the UN climate change summit, addressed the UN Climate Change Conference COP 21, in Paris .. He presented Nigeria's statement at the opening session.
On Tuesday, December 1,he will participate in the summit of Heads of State and Government of the Lake Chad Basin Commission and Benin Republic where issues on security challenges of the region will be discussed and also attend another event of the African Union, tagged 'Conference on Climate Change and Africa Solutions.
Another below
On Tuesday, December 1,he will participate in the summit of Heads of State and Government of the Lake Chad Basin Commission and Benin Republic where issues on security challenges of the region will be discussed and also attend another event of the African Union, tagged 'Conference on Climate Change and Africa Solutions.
Another below
Pastor's 17 year old son rapes,murders 14-yr old girl in Delta
According to Vanguard ,the incident occurred at Oduduru Road, Sapele, same street where a kidnap gang shot dead a young pastor, Great Oduduru, last week.A source said worshipers at the suspect's father's church were shocked at the conduct of his son, which they described as unbecoming of cleric's son. .
Ben Bruce says Buhari should reduce his foreign trips
Peter Okoye shares adorable photos of his daughter Aliona
Photos-Violence erupts outside APC headquaters Abuja over Kogi election
Over 1, 000 youths stormed the secretariat of the party where APC leaders are holding a meeting over the Kogi state election.
On sighting Yahaya Bello, they went out of control, attempting to attack him.It took the combined effort of security agents to smuggle Bello from their midst.
All Woman! Serena Williams,Amy Schumer strip for Pirelli 2016 calendar(Photos)
Photos from Miss Criminal 2015 beauty pageant
She has been behind bars since 2010, when she was sentenced to 39 years for robbery - with an additional six years added on for prostitution inside the prison.
The women try on different dresses, have their makeup and hair styled by volunteers and even perform catwalk poses in the Miss World-style contest.The contest aims to boost the self-esteem of female inmates and is supported by community and church groups.
Toyin Lawani and her kids slay in matching outfits(Photos)
Fmr. president Jonathan narrowly escapes death after men trailed his convoy to his home(Photos)
Former President Goodluck Jonathan this morning when some suspected militants in Bayelsa State drove into his convey.
According to Ladershipng,the men, who intercepted and drove into a short motorcade conveying the former President from the Julius Berger bridge area of the state capital Yenagoa, trailed and chased the motorcade to the entrance of the Yenagoa private residence of the former President in the Kpansia area of the town, before they were overpowered and arrested by a combined team of security operatives attached to the former President.
Investigations are still ongoing.
Farmer refused to eat this potato because it is too 'sexy'
Spot anything wrong with this pic of Genevieve Nnaji and Oris Erhuero?
Toyin Lawani stuns at the 2015 ELOY Awards
Dakore Akande dazzles in red
(Photos)How terrorism, politics and a plane crash have left Egypt's tourist hotspots deserted
|fake Sphinx in Sharm el Sheikh
Married photographers Andrea and Magda have documented the Sinai region including resorts such as Sharm El Sheikh and Nuweibaa. They spent nine months touring the area after finding more and more of the places they had previously visited were closing down.
I don't get awards because of politics in the industry-Burna Boy
Speaking to The Fader magazine,he said
He said, "It's political, man. To be honest, I don't really feel like I'm a part of the industry. Check out awards, I don't get awards because the powers that be don't really like me. I'm not like everyone else; I won't do what everyone else does. They don't like it.Everything is really political, too much politics in the industry and I'm not a very good politician.
British mother hopes to be ISIS first suicide bomber
A mother-of-two from Britain who is known as 'Mrs Terror' has hinted she may become ISIS' first female suicide bomber.
Muslim convert Sally Jones - whose extremist husband was killed in an American drone strike - indicated she was planning on blowing herself up after paying tribute to the first female Chechen suicide bomber.
Muslim convert Sally Jones - whose extremist husband was killed in an American drone strike - indicated she was planning on blowing herself up after paying tribute to the first female Chechen suicide bomber.
Hussain, posted the last words of Hawa Barayev, who killed herself and 27 Russian special forces soldiers in Chechnya in 2000.According to the Sunday Times,the 47-year-old former rocker wrote
Waconzy spotted at the White house in Washington DC(Photo)
Singer Waconzy was recently at the white house in Washington DC.According to reports,he has been having talks with some top US government officials on how to eradicate malaria in Africa.
In his fight against Malaria and as a a way of giving back to society ,Waconzy's new Single Powerful which is set to drop December 12th. is now available for download on itunes https://itunes.apple.
com/us/album/powerful-single/ id1060747130 and all sales from this track will go to charity and his fight against malaria.
Nice one..
Nice one..
Adorable-Shakira and sons support Gerad Pique during Barcelona match
Donjazzy 'praises' Vic O's Hello cover
Kylie Jenner Explains Why She Prefers Caitlyn To Bruce Jenner
"I like her better than Bruce, "We talk about makeup and clothes. We bond a lot more, but not only that. I feel like there's not a huge secret in the family. I feel like there was always this big secret.And I've honestly known about it for a really long time and we actually caught him then dressing up as a girl. When my sister and I were like 6 and 7 maybe. So we've known for a while that there was something, but it was never talked about."(Continue)
21-year-old stabs Lagos landlord to death(Photo)
|Elepo and Lateef
Some hoodlums started a street fight on Olorogun Street, Odo Eran, in the Itire area of Lagos State on Tuesday, during which a 21-year-old stabbed a landlord, identified as Alawu Lateef, to death.
PUNCH Metro learnt that Lateef, who was a father of three, had intervened in the fight, and asked the hoodlums to leave the area, when one of them, identified as Lati Elepo, stabbed the landlord.
It was gathered that the father of three slumped, while residents arrested Elepo before he could escape with the other hoodlums. The matter was said to have been reported at the Itire Police Division.
Outrage as TIME Magazine asks if Kim Kardashian & Caitlyn Jenner should be it's Person of the Year
Adorable photo of Jude Okoye' daughter at her birthday party
Flavour and Chidinma Share Intimate Kiss on Stage(Photos)
Man Declared Wanted By EFCC For Eloping With N45million tells his own side..
A few days back, the EFCC declared the Jerry Ogbonna wanted for allegedly absconding with N45m mistakenly credited to his account..Now, the man in question responded on facebook.He claims the money was not paid in error but was for a contract he had with the Ministry of Petroleum Resources for the lease of three (3) helicopters from Tunisia for the Department of Petroleum Resources (DPR).
Read his side below
Artiste gets buried in magnificent shoe casket in Akwa Ibom(Photos)
Emmanuel Emmanuel Udoh who was at the burial..
Today I was at the Burial ceremony of one of the greatest artists to come out of the south south to pay my last respect.Indeed he left a big shoe to be filled.A great artist and sculpture.
This masterpiece casket was done by 2 of his kids who took after him. Both great graduates of Fine Arts!
Sunday, 29 November 2015
Susan Peters stuns at the ELOY Awards
Lil Wayne gives daughter a 2016 Range Evoque for 17th birthday (Photos)
Rapper Lil Wayne gave his eldest child and only daughter a 2016 Range Rover Evoque for her 17th birthday .For her 16th birthday ,33 year old Lil Wayne who has 3 sons from 3 other women gave her 2 cars – a Ferrari and BMW.Her mother is Toya Wright who is said to be his first love.He had his daughter Reginae Carter at 16.
She wrote Thanks mommy and daddy ✨ I love you guys more than life I swear
Lupita rocks longer hair for Rhapsody magazine (Photos)
Buhari leaves Malta for France
President Muhammadu Buhari has left Malta where he participated in the Commonwealth Heads of Government Meeting (CHOGM) for Paris, France .He is expected to join about 150 other world leaders for the Conference of Parties 21 (COP21) on climate change.
The president is to present Nigeria's statement at the opening session today before participating in the launching of the International Solar Alliance same day.
Juliet Ibrahim dazzles (Photos)
Singer Sinead O'Connor posts 'suicide note' on Facebook
The singer,and mother of four who underwent a hysterectomy in August is best known for her 1990 hit 'Nothing Compares 2 U',She wrote on her Facebook message :
Agbani Darego steps out in style(Photos)
Kate Middleton releases adorable photos of 6 month old Princess Charlotte
Mum Kate took the snaps in her country home Anmer Hall earlier this month and the Kensington Palace official Twitter account tweeted them today.
The last time the princess was photographed was at her christening on Sunday July 5.
Why Scott Disick fought to win back Kourtney Kardashian
It has also been revealed that now,she has given him new rules to abide by or he risks being kicked out again..
Manager David Weintraub told Heat Magazine:
Awww! Jude Okoye shares the cutest pics of his daughter as she turns one
Davido gushes over being a father(Photo)
Dabota Lawson shares sexy pic after being 'pissed off''
The ex beauty queen and billionaire wife decided to flaunt her hot body in response to being pissed off.She wrote
When somebody thought pissing me off this morning was a good idea.. I proceed to match up by posting a pic like this..#rulemakerfollowtherulesI don't think she has bared her skin like this since she got married..Sounds like she's trying to make someone jealous.. ...Hope not the hubby!
Kate Henshaw wows in bangs
The Man Who Would Be Governor By Reuben Abati
Rick Ross tattoos his head and face(Photos)
Big Boys Swag-Dbanj and Banky W stylish in coordinated black outfits
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You know Marvel was once so broke they almost sold their rights to Michael Jackson. Yep, Mike Jack wanted Marvel, and not just because he was a good guy who loved comics. Mr. Jackson, God rest his soul, wanted to be your friendly neighborhood Spider-Man! Seriously! Stop and imagine a world where Michael Jackson replaces Tobey McGuire and director James Cameron replaces Sam Rami! Alas, Marvel decided death before dishonor and sent many of their most popular franchises spiraling in many different directions. But they weren't dead just yet.
As we all know, Disney eventually got ahold of Marvel and turned superheroes, who some might forget weren't that popular, into icons. When I was a kid in the 90s I watched the Spider-Man and X-Men cartoons. Not Iron Man or Thor and certainly not that boy scout Captain America! That didn't stop the magical beast known as the MCU from forming, and my, oh my, how the tides turned! What once was on the verge of extinction rose from the ashes and became a forced to be reckoned with! And on the other side, O, how the mighty have fallen!
The superhero franchise that arguably created the genre came crashing down in the form of Andrew Garfield failing to catch Emma Stone, just like Sony failed to capture the magic of everyone's favorite web-slinger. But what about Fox? What were they up to? Well that's hard to pinpoint because the X-Men franchise has always been a bit hit and miss, while the MCU has kept a high batting average. Marvel struck a deal with Sony to get their sticky fingers on Spider-Man, because Sony hypothetically webbed themselves into a corner with the Amazing Spider-Man 2. Now after the mixed reviews (an uninspiring 48% on Rotten Tomatoes) of X-Men Apocalypse, is Fox ripe for the picking?
Let's Face it, X-Men needs a Reboot
16 years of colorless costumes is enough! Fox cannot continue to fix every one of their atrocities with time travel! Not to mention, Hugh Jackman said he's not coming back after his next movie and Bryan Singer has stated he is done with the X-Men franchise. This all points to one thing! It's the perfect time for Fox to throw everything out the window and start fresh and the best way to do that would be to join the MCU and introduce an entirely new cast of X-Men! The fan excitement over the X-Men joining the MCU would far outmatch the angst and uncertainty surrounding a reboot.
Plus, It's Not Just X-Men
Fox also owns the rights to Deadpool, Cable, Fantastic Four, and the Silver Surfer franchises and all the great characters that come with them. Even if Fox is reluctant to give Marvel all of their characters, there is an opportunity for the MCU to make one of their weaknesses a strength. If a deal could be struck where Marvel could get some of their greatest villains back it would really take them to a new level. Just imagine an Avengers film with Galactus! (The little kid in me just screamed!) If you want to see exactly which characters belong to who, here is a detailed list.
Fox Would Still Have the Rights
Some say Fox shouldn't give up X-Men because then Marvel would own almost every marketable hero not named Batman or Superman. It's a fair point, however, Sony still owns the rights to Spider-Man and the solo Spider-Man movies, and it would be the exact same situation with X-Men. Fox would still own the rights, the only difference would be that they'd allow some of the characters would join the MCU, which is something that everyone wants! We want to see Storm married to Black Panther, and Deadpool hanging out with Spider-Man, and Reed Richards outsmarting Tony Stark! We want it all! But we'd settle for just a taste!
Will It Happen?
In the words of Justin Bieber (and many great men before him) never say never! But in reality, it would be very hard for this to work out. Why? Fox is doing fine! They aren't in nearly as bad of shape as Sony was when they handed over one of the greatest heroes of all time. Why? Well you can thank Mr. Pool for that. Fox knocked it out of the park with Deadpool which was exactly what their X-Men movies SHOULD be. It was so good and stayed so true to the character that it has outgrossed every comic book movie this year besides Civil War! So Fox isn't exactly sitting with its hands tied behind its back begging for Marvel's help. Do they know what they're doing like Marvel? No. Are they making enough to be happy? Absolutely! What we should hope for is a deal where certain characters will be offered to Marvel, and Marvel will offer up some of its characters to Fox for crossover purposes. Make it a two way street where fans can see Hulk fight Wolverine and the Avengers fight Galactus and let the money pile for both companies. All things being equal I think it makes a lot of sense.
But what do you think? Should Marvel and Fox come to an agreement or should the franchises stay separate? Let me know your opinion in the comment section and vote in the poll!


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Read Chapter One of THROUGH HER EYES! Click here!
4 Stars
"Now THIS is an example of American Western Romance at its very best! It is stuffed with deep emotions, gritty reality, and pitch-perfect plotting! Not only does the author paint a beautiful and believable love-story that grows naturally, but she tackles many social issues from the time period like racial and class prejudices in a way that brings awareness without preaching. It is a book one can't put down and will be remembered long after the last page is turned."-- Ruth Lynn Ritter for InD'tale Magazine
The Civil War is over, but the battles continue.
Click here to see the first few pages of Deborah's new western romance that is available to order now on Amazon.


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Melatonin is a small, highly conserved indole with numerous receptor-mediated and receptor-independent actions. Receptor-dependent functions include circadian rhythm regulation, sleep, and cancer inhibition. The receptor-independent actions relate to melatonin's ability to function in the detoxification of free radicals, thereby protecting critical molecules from the destructive effects of oxidative stress under conditions of ischemia/reperfusion injury (stroke, heart attack), ionizing radiation, and drug toxicity, among others. Melatonin has numerous applications in physiology and medicine.
When Aaron B. Lerner and his associates (29) isolated and characterized the methoxy derivative of serotonin from bovine pineal tissue near the middle of the last century, in their most optimistic outlook they would never have envisioned the multiple functions this molecule would eventually display. As dermatologists, they had engaged in this effort because, based on a publication that appeared 50 years earlier (35), they knew there was something in the pineal gland that blanched cutaneous chromatophores and thereby lightened the skin of amphibians. Indeed, the name they selected for their newly discovered molecule, i.e., melatonin, is in part based on its effect on skin pigmentation ("mela" from melanin and "tonin" from serotonin).
After melatonin's discovery in pineal tissue, the image of the gland quickly changed from that of a functionless vestige to one of an active organ of internal secretion. Biochemists identified the steps in the synthetic pathway of melatonin (4, 41, 67) (FIGURE 1), and the physiologists described a now well known function of the pineal, i.e., the regulation of seasonal reproduction in photoperiod-sensitive mammals (22, 24). By the end of what has been referred to as the Decade of Transformation (mid-1950s to mid-1960s) (7), the pineal gland and melatonin were both recognized as legitimate components of the endocrine system: the pineal was known to synthesize melatonin (67), the gland influenced seasonal reproduction in photosensitive species (23, 24), and it required its sympathetic innervation to remain functional (43, 66).
Research within the last 60 years, however, has revealed that melatonin is functionally much more diverse than being only a regulator of the neuroendocrine-reproductive axis in photoperiod-dependent, seasonally breeding mammals. Also, the conflating of melatonin exclusively with the pineal gland has been shown to be untenable (47). Herein, we briefly summarize the data documenting the heterogeneity of melatonin's multiple actions and the evidence that melatonin is produced in all plants and animals that have been studied.
Unconventional Aspects of the Pineal and Melatonin
In vertebrates, the pineal gland synthesizes melatonin in a circadian fashion, with nighttime darkness being a requirement for maximal production (57); because of this, melatonin is referred to as the chemical expression of darkness (42). The influence of the prevailing photoperiod on circadian melatonin production is accomplished by a restricted bandwidth of visible light, i.e., wavelengths in the range of 460–480 nm (blue light) (FIGURE 1). These wavelengths account for the inhibition of melatonin synthesis in the pineal gland during the day or, if they occur, at night. For the retinal processing of blue wavelengths, the mammalian retinas have up to five highly specialized subtypes of intrinsically photosensitive retinal ganglion cells (ipRGCs), which use a specialized photopigment, melanopsin, to respond to light (31, 68). The message related to the light environment is then transferred to the central biological clock, the suprachiasmatic nuclei (SCN), in the hypothalamus via the retinohypothalamic tract, which is embedded in the optic nerve. The SCN is a critical relay center that conveys a neural signal to the pineal gland (39) (FIGURE 1). The neural message arrives at the pinealocytes from the SCN via the central and peripheral sympathetic nervous system. This is one of several features that distinguishes the pineal from classic endocrine organs, i.e., its output is governed by a neural input, which, if destroyed, renders the gland totally inept (43); likewise, feedback effects from peripherally derived hormonal signals are usually not considered to be major factors in changing the quantity of melatonin produced or altering the phasing of its rhythm (11). Hence, the melatonin rhythm is more or less independent of endogenous influences, and melatonin synthesis is determined almost exclusively by the prevailing photoperiod, thereby making the pineal an unconventional endocrine gland.
There is also nothing phylogenetically that ties melatonin production to the pineal gland. Melatonin is not unique to vertebrates but is also produced in invertebrates, unicells, and plants, none of which possess a pineal gland and some of which, i.e., unicells, have no organs whatsoever (37, 50, 51). These nonvertebrates need melatonin for some of the same reasons vertebrates do, e.g., as an antioxidant (37). Some plants already have been genetically engineered to produce elevated quantities of melatonin, which protects them from free radical-producing environmental stressors (temperature extremes, drought, disease) (8, 9).
Melatonin probably evolved more than 2.5 billon years ago, likely in purple nonsulfur bacteria, presumably in Rhodospirillum rubrum (61), to protect them from an oxidizing environment that was a consequence of increasing atmospheric oxygen concentrations associated with the Great Oxygen Event (the Oxygen Catastrophe). These melatonin-producing bacteria were subsequently phagocytized by eukaryotes, a process referred to as endosymbiosis, where they eventually evolved into mitochondria. Because of this, we have speculated that mitochondria in all eukaryotic cells may have retained the ability to produce melatonin (61); if so, all tissues in multicellular organisms generate melatonin for their own use (64).
Of interest in this regard is that melatonin concentrations in the mitochondria of rat hepatocytes greatly exceed blood levels, and they do not drop after pinealectomy, which depletes melatonin from the blood (64). Many extrapineal organs, as sites of melatonin production, have been identified in vertebrates. Unlike the pineal gland, most of these organs (exception, the retinas) may not synthesize melatonin in a circadian manner nor do they release it into the blood in any significant amount. Rather, in these organs, melatonin functions as an antioxidant, as an autocoid, or as a paracoid to regulate intracellular events.
Another misconception that should be dispelled is that blood melatonin levels are representative of its concentrations throughout the body. This is clearly not the case given that the bile (58) and the cerebrospinal fluid (54) have melatonin concentrations that exceed those in the blood by several orders of magnitude, and, as already noted, intracellular levels are also higher than those in the blood. Thus, because of its unequal distribution, blood melatonin concentrations should not be used to judge melatonin levels in other body fluids or within subcellular compartments (47).
Melatonin, Its Potpourri of Actions
Receptor-Mediated Actions
Melatonin has an uncommonly large skill set, and, considering that melatonin is billions of years old, it has had ample time to hone its functions. For several decades after its discovery, melatonin was assumed to mediate all of its actions via receptors that were bound to membranes of a limited number of cells, e.g., neurons of the SCN (56). Two membrane receptors were pharmacologically characterized, subsequently cloned, and are now identified as the MT1 (Mel1a) and MT2 (Mel1b) receptors. These are both members of the superfamily of transmembrane, G-protein-coupled receptors. The MT1 receptor is 350 amino acids in length, whereas MT2 consists of 363 amino acids; the receptors share 60% homology (14). There is also an orphan molecule referred to as a melatonin-related receptor (MRR; also called GPR50) that shares 45% homology to MT1 and MT2; little is known of its function. In contrast to the original assumption that the membrane melatonin receptors were located on only a few cells, subsequent investigations have in fact localized them on many cells (55), and they may exist on the membranes of all cells.
There is also what is referred to as an MT3 receptor located in the cytosol of a few cells. It is not coupled to a G protein and exhibits low affinity for iodo-melatonin; it may be equivalent to quinone reductase 2, a detoxification enzyme (21). Finally, melatonin may carry out some of its activities by an interaction with a group of nuclear receptors referred to as retinoid orphan receptors (ROR) or retinoid Z receptors (RZR). The superfamily members that reportedly bind melatonin include the RORα, RZRα, RORα2, and RZRβ. These nuclear receptors contain an NH2-terminal domain, a DNA binding domain, a ligand binding domain (in the COOH terminal), a zinc double finger, and a hinge region. The nuclear receptors may be differentially distributed among tissues (1) and perhaps are best functionally described in the immune system (12, 27). In most cases, their specific functions are under debate.
Receptor-Independent Actions
In addition to its abundant actions mediated by its multiple receptors described above, melatonin also directly detoxifies reactive oxygen species (ROS) and reactive nitrogen species (RNS) by nonreceptor-mediated means (45). Like some other classic radical scavengers, major chemical mechanisms by which melatonin ensnares radicals include single electron transfer and hydrogen transfer, but other yet to be defined processes may be involved (15). Consistent with its presumed high intramitochondrial concentrations, melatonin improves the activities of several respiratory chain complexes, thereby reducing electron leakage and free-radical generation (34), a process referred to as radical avoidance (20). Moreover, metabolites of melatonin [cyclic-3-hydroxymelatonin (c3OHM), N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), and N1-acetyl-5-methoxykynuramine (AMK)] (FIGURE 2) provide additional protection against oxidative damage by the same mechanisms described above for melatonin and perhaps also by radical adduct formation (16, 17, 48, 59, 62).
The relative efficacies of melatonin, c3OHM, AFMK, and AMK as scavengers of the hydroxyl radical (·OH) and the hydroperoxyl radical (·OOH) have been examined in several settings. These results were generated using a variety of techniques, including functional density theory. Although there are slight differences in their relative efficiencies, each of the four molecules scavenge the highly reactive ·OH at diffusion-controlled rates, regardless of the polarity of the environment. Thus they are all highly effective scavengers of the devastatingly reactive ·OH (17, 59, 62).
With regard to the ·OOH, neither melatonin, AFMK, nor AMK are particularly effective in neutralizing this agent. This is consistent with melatonin per se being an inefficient chain-breaking antioxidant (33) but inconsistent with the data showing that both in vitro and in vivo melatonin markedly reduces lipid peroxidation (45). This action was then assumed to be a consequence of melatonin's ability to prevent the onset of lipid peroxidation by neutralizing the initiating agents, ·OH and the peroxynitrite anion. Subsequently, it was found, however, that c3OHM, in contrast to the other three molecules, is highly effective in scavenging the ·OOH (17, 59). Moreover, c3OHM was found to detoxify the ·OOH almost 100 times faster than trolox (water soluble vitamin E). This is remarkable since vitamin E is considered the primer peroxyl radical scavenging agent and inhibitor of lipid peroxidation. The conclusion of these studies is that melatonin both limits the initiation of lipid breakdown and reduces its propagation when the metabolite c3OHM scavenges the ·OOH.
Melatonin also reportedly detoxifies the strong oxidizing agent, the peroxynitrite anion (ONOO−) and hypochlorous acid (20). Whether melatonin's metabolites likewise function in these capacities remains untested.
To illustrate the importance of melatonin as an antioxidant, throughout evolution, no organism that has been investigated has lost the ability to synthesize this indoleamine, as is the case with some other radical scavengers, e.g., vitamin C. Additionally, besides being endogenously produced, melatonin is ingested in the diet of all animal species given that it is produced in plants (28). These dual routes ensure that melatonin is always available, again unlike some other radical scavengers. Finally, at least in some animal and plant species, melatonin synthesis is upregulated under circumstances where free-radical generation is exaggerated (3). This greatly increases its protective activities.
Related to melatonin's capability of reducing molecular damage due to free radicals are its effects on anti- and pro-oxidative enzymes (45). These actions are prominent and highly reproducible but, mechanistically, not well investigated, although preliminary evidence suggests the involvement of the membrane receptors MT1 and MT2 (49). The major antioxidative enzymes that are stimulated by melatonin under basal conditions include the intracellular superoxide dismutases (CuZnSOD and MnSOD), the selenium-containing glutathione peroxidases (GPX1, GPX2 and GPX3), and catalase (CAT) (FIGURE 3). Conversely, under toxic conditions of high oxidative stress, these proteins are protected from free-radical damage, and their enzymatic activity is preserved. Melatonin also maintains the activities of enzymes that enhance intracellular levels of reduced glutathione (GSH), an important intracellular antioxidant. Thus melatonin promotes glutathione reductase (GRd) activity, which reduces glutathione disulfide (GSSG) to the sulfhydryl form of GSH and γ-glutamylcysteine ligase (GCL), the rate-limiting enzyme in GSH synthesis (63). The pro-oxidative enzymes inhibited by melatonin include nitric oxide synthase, myeloperoxidase, and eosinophil peroxidase (20).
Melatonin Doses and Timing of Administration
When melatonin is to be used, the dose and timing of when it is given may be critical in determining its efficacy as a treatment. The doses typically used in animal/human studies for membrane receptor-mediated circadian rhythm regulation are usually lower than those used for defeating free radicals, an action that is membrane receptor independent. Moreover, when melatonin is used in situations where an influence on circadian processes is a factor, e.g., sleep in humans, melatonin should be taken in the evening before sleep. Conversely, if the purpose of melatonin use is to harness free radicals, melatonin would be most effective if given when the free radical event, e.g., stroke, occurs, regardless of the time of day.
The statement has been made that melatonin functions as a free-radical scavenger only when given in amounts that are considered pharmacological. This is incorrect. For any scavenger, even a single molecule is capable of neutralizing a radical. To combat the massive number of free radicals generated under conditions of severe oxidative stress, however, pharmacological amounts of any antioxidant must be given to neutralize the overwhelming numbers of these toxic brigands that are produced. Vitamins C and E, for example, are often taken in gram quantities, even under conditions where severe oxidative damage is not a consideration. Thus, when melatonin is used to reduce free-radical destruction, it is given in pharmacological doses since the free radicals are also being produced at "pharmacological" levels.
Melatonin Isomers
Isomers of melatonin have been identified in plant products (19, 65), and we have predicted they will eventually be found throughout the plant and animal kingdoms (60). Isomers are molecules with the identical molecular size as melatonin; they also possess the same methoxy residue and the aliphatic side chain as melatonin itself, but they are in different locations on the indole nucleus. Presently published reports show that the isomers bind to classic membrane melatonin receptors and function in free-radical detoxification (60).
Melatonin: Functionally, a Swiss Army Knife
Like the multi-tooled device bearing the Swiss coat of arms, melatonin has a bewildering array of functions and employs a variety of means to carry them out (FIGURE 4). These actions likely impact every cell in every organism throughout the plant and animal kingdoms. As a consequence, the physiological and pathophysiological actions of melatonin are numerous.
Melatonin is best known for its mediation of circannual variations in metabolism and reproductive competence in photosensitive species (5), its ability to influence circadian processes that are ubiquitous in organisms and in cells, and its sleep-promoting activity (10). Each of these functions relies on the circadian message provided by the pineal-derived blood and cerebrospinal fluid melatonin rhythms that are transferred to cells that "have a need to know." Melatonin is not impeded by any of the known morphophysiological barriers, e.g., blood-brain barrier, blood-testis barrier, etc., and it readily crosses the placenta in an unaltered form to impact the fetus (46). Melatonin's concentration in some bodily fluids, e.g., CSF, bile, etc., exceeds that in the serum by several orders of magnitude. Likewise, at least in those cells where measurements have been made, subcellular organelle melatonin levels are greater than in the blood and may not rely on the blood as a source of their melatonin (36, 64). We have speculated that all cells have the capability of synthesizing melatonin, particularly in their mitochondria. This locally produced melatonin is for protection from free radicals and from cells in the neighborhood via autocoid and paracoid actions and is not normally released into the blood.
Receptor-independent actions of melatonin and its metabolites relate to their ability to directly quench free radicals and nonradical, but toxic, species. Excessive free-radical generation is notoriously destructive and kills cells secondary to massive oxidative damage, which induces cellular apoptosis or necrosis. The loss of cells due to programmed cell death is a consequence and/or contributes to many diseases as well as to age-related deterioration. Melatonin's ability to prevent molecular damage meted out by free radicals and the cellular mutilation becomes manifested when the indole protects against that destruction. Such damage can be produced by ultraviolet and ionizing radiation–ingestion of toxins, heavy metals, alcohol, and prescription drugs–smoking, ischemia/reperfusion injury, which occurs during a heart attack or stroke, severe inflammation, neurodegenerative diseases, and many other pathophysiological situations (45).
Similarly, aging is associated with the progressive accumulation of oxidative debris, which contributes to functional inefficiency of cellular processes, thereby inducing additional free radicals to be produced. Thus aging becomes a vicious cycle. As molecular processes fail, oxidative damage accumulates, which leads to additional physiological collapse, further exaggerating the production of free radicals. Melatonin, because of its ability to neutralize radicals, defers age-related dysfunction of several organs (22).
Increased age leads to a gradual diminished melatonin production such that, in the elderly, the nocturnal melatonin rise in the circulation is either greatly attenuated or it no longer exists. The consequences of this reduction may be highly significant in terms of health (44). Since the cycle of melatonin strengthens circadian rhythms by acting at the SCN and also on peripheral slave oscillators, normal circadian rhythms deteriorate, and, considering their importance for optimal health, the dysregulation of these rhythms, e.g., the sleep/wake cycle, negatively impacts organisms. Additionally, the loss of melatonin during aging contributes to the accelerated accumulation of oxidative stress due to the reduced availability of this important antioxidant. This presumably contributes to the progression of diseases that have a free-radical component, e.g., neurodegenerative diseases (52), cardiovascular disease (13), skin deterioration (25), and metabolic syndrome (38), among others. In experimental studies, supplementing aging animals with melatonin defers some of these debilitating changes (22).
Some functions of melatonin may depend on both receptor-mediated events and on receptor-independent processes. As an example, melatonin inhibits the proliferation of many cancer cells (40) as well as limiting tumor metastases (32). The ability of melatonin to forestall cancer cell division and the molecular processes associated with the relocation of cancer cells to a secondary site may involve the classic membrane receptors that these cells possess as well as its receptor-independent antioxidative functions; the latter also may account for melatonin's ability to promote apoptosis of cancer cells (6). This pro-apoptotic action of melatonin in cancer cells is diametrically opposite to its anti-apoptotic function in normal cells, a differential action that has been difficult to explain (6).
Melatonin, Its Special Association With Mitochondria
Mitochondria are a major site of free-radical generation since electrons that are fumbled during their transfer through the electron transport chain reduce molecular oxygen to the superoxide anion radical (O2·−). This oxidizing agent is quickly dismutated to form hydrogen peroxide (H2O2), which is transformed, in the presence of transition metals, to the ·OH (FIGURE 3). Alternatively, O2·− may couple with nitric oxide to produce the highly toxic ONOO−. If the prediction that melatonin is produced in mitochondria is valid, its generation in these organelles would be a major advantage for reducing mitochondrial damage and preserving energy production.
Melatonin is highly effective as an antioxidant at the mitochondrial level (2). When compared with synthetically produced, mitochondrial-targeted antioxidants Mito Q and Mito E, which are concentrated up to 500-fold in mitochondria (18), melatonin still performed better in reducing every aspect of damage to this organelle (30). The implication is that melatonin, when administered via any route, is absorbed and makes its way to mitochondria in sufficiently high amounts where it is more effective than the synthetic antioxidants, which are known to accumulate in the matrix of mitochondria, in preserving the function of these critically important organelles. Thus, besides being produced in mitochondria, when it is taken as a supplement or consumed in the diet it is readily available to mitochondria. Thus melatonin may be classified as a naturally occurring, mitochondrial-targeted antioxidant. Melatonin may have regulatory actions on mitochondrial uncoupling protein, but these functions remain poorly defined.
Conclusions and Perspectives
Melatonin's flummoxing array of physiological actions as well as the numerous means by which these actions are mediated supports the idea that melatonin is a multitasking molecule. Regarding both these features, melatonin has certainly exceeded the expectations of the most ardent melatonin devotees. Yet, there is likely more to come.
Stable circadian rhythms, which melatonin aids in regulating, are crucial for the optimal generalized physiology of organisms and for the microphysiology of molecular functions. Likewise, melatonin's ability to modulate oxidative processes and protect against free-radical mutilation of essential molecules is indispensible for flawless cellular function.
Research on melatonin seems to be at the "end of the beginning." Obviously, extensive research has been performed regarding the actions of melatonin in experimental cells, plants, and animals. Its uncovered actions are uniformly beneficial, although not all the specific mechanisms have been described. In addition to its multiple positive physiological actions, melatonin has an uncommonly high safety profile. Thus it is time to advance this research to the next level, i.e., to more extensively test its use in clinical trials (26). Although small steps are being taken in this direction (53), it is essential that multi-centered, blinded, well controlled studies be performed using adequate amounts of melatonin and for appropriate durations to determine melatonin's ability to defer or prevent certain diseases, as suggested by the numerous experimental studies that have been performed. This is especially important since prevention always trumps treatment.
No conflicts of interest, financial or otherwise, are declared by the author(s).
- ©2014 Int. Union Physiol. Sci./Am. Physiol. Soc.
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Head Fashions
Fashion is not just about the clothes you wear, or the phone that you use. Nor is it really about having the latest of anything, the newest, smartest, most expensive. It is far more about your overall appearance, the way you carry yourself, the level of self-confidence you exhibit. Most people cannot tell whether a dress is just off the Paris catwalk anyway, they look to see how it works, what a difference it makes as a part of the whole picture. A woman's hair, alongside many other factors, is of vital importance when trying to attract, when trying to fit into a certain situation, when trying to be In.
It is also, I must add, an anti-fashion statement, something which has become very popular – even fashionable – since Sinead O'Connor. Although, thinking about it, this line of hair cut lost its popularity with a rush when Brittney Spears stepped in!
Photo Credit: Peter – Creative Commons
Today I saw a young woman sporting a very individual style. The sides were shorn and black, but not so short that her skin showed through too much. The rest, everything above the ears, I can only describe as being like a thistle in full bloom. An amazingly vivid color comprising different hues and highlights.
She was gone too quickly for me to capture her image, but it remains in my mind although, to be honest, my illustration does not do her justice. And it fit. She looked good, she looked confident, she sported her unusual hair color – unusual for a small town in Germany – very well indeed.
It takes all sorts to make a world, and I am sure she will know how difficult it is to fit in with a conservative world where such colors tend to push people into pigeonholes very quickly indeed, but it is good that there is such variety, and that people have something to talk about even if they don't trust themselves enough to take a risk and step out of the main line.
Love & Kisses, Viki.


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- Categories: Anime, H, News
- Date: May 3, 2017 06:10 JST
- Tags: Adaptations, Animation, DLSite, Doujin Soft, Fetish, Image Gallery, Oppai, Oshiri
A new erotic animation from Boom Boom Douga unsurprisingly possesses a ridiculous concept, with "Cheater's Harem" (a motion comic adaptation of a popular visual novel) being about the revival of a male into a world where women can become personal objects through the power of sex, no doubt a situation that any red-blooded male would hail as a paradise.
Recently revived hero Yuuji Mihara quickly establishes that he wants to create his own harem in this twisted new world, one potential setback to his plan however is his premature ejaculation problem, a trait that otaku may be able to sympathize with.
The saucy animation that is Cheater's Harem can be observed by all now.


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critical WPA2 vulnerabilities afoot, see KRACK attacks (discussion @ /r/KRaCK, HN, /r/netsec, Slashdot)
FCC approval date: 21 March 2012
Country of manuf.: China
Type: access point
Power: 5 VDC, 0.5 A
Connector type: USB Micro-B (female)
FLA1: 4 MiB
32,768 Kib
4,096 KiB
32 Mib
0.00391 GiB
RAM1: 16 MiB
131,072 Kib
16,384 KiB
128 Mib
0.0156 GiB
Expansion IFs: none specified
WI1 chip1: Ralink RT5350F
WI1 802dot11 protocols: bgn
WI1 MIMO config: 1x1:1
WI1 antenna connector: none
ETH chip1: Ralink RT5350F
LAN speed: 10/100
LAN ports: 1
Flags: portable
Default SSID: BL-MP01-XXXXXX
Default IP address: 192.168.16.254
the IP 192.168.16.254 is used by 2 additional devices
of which 1 are B-LINK devices
Default login user: admin
Default login password: admin
admin:admin credentials used by 1035 additional devices
of which 4 are B-LINK devices
802dot11 OUI: 20:F4:1B
The default SSID pattern appears to be BL-MP01-XXXXXX where XXXXXX
- is the last three octets of the BSSID (upper case letters).
Flash: PMC (now Chingis, part of ISSI) Pm25LQ032 4MB (32Mb)
- Chingis Technology PM25LQ032 Datasheet
- newer generation flash, with 4KB sectors and 32KB blocks


text:
Designed for:
Filtration element:
Other characteristics:
high-efficiency, mini-pleat, high-capacity, chemical, V-form
Flow rate:
Min.: 1000 ft³/min (28.32 m³/min)
Max.: 2000 ft³/min (56.63 m³/min)
V-FORCE filters offer an excellent option for
applications currently using rigid cell style
extended surface filters. They are a good
replacement for corrugated separator style
or supported pleat style rigids.
• All Plastic Construction
• 100% Synthetic Media
• Fully Incinerable
• Moisture and Chemical Resistant
• Rigid Cell Design
• Low Resistance
• Light Weight
All Plastic Construction – No Metal Components
V-FORCE filters are made from high strength, high
impact polystyrene plastic. They contain no metal
components. No rust, no corrosion.
100% Synthetic Media – Durable, Damage
V-FORCE filters are made with synthetic media. It is
extremely durable, resists tearing and abrasion, and is
highly damage resistant. No more media damage during
shipping, handling, or installation. This media is just
plain tough.
Fully Incinerable – Aids Disposal
All plastic components with synthetic media make
V-FORCE filters completely incinerable. Growing
restrictions on landfills in many areas make incineration
the most viable disposal option.


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What does Paula Gunn Allen see as some practical consequences of Eurocentric patriarchal distortions, as she sees them, in relation to her "Kochineko Academe"?
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One consequence of Eurocentic patriarchal distortions imposed through global colonization that Paula Gunn Allen identifies is the regendering of global concepts of gender. It is pointed out that tribes, such as that of the Yoruba society, whose gender concept recognized three genders and homosexual relationships, were forced into reorganization to a Eurocentric patriarchial gender and relationship concept in the same way that matrilineal societies, that took responsibility along and handed wealth down through matrilineal connections, were forced into Eurocentric patrilineal reorganization so that wealth and responsibility were reorganized along and through patrilineal lines (matrilineal: the mother's brother's financial responsibility, wealth to mother's daughters; patrilineal: the husband financial responsibility, wealth to the husband's sons).
This gender reorganization corresponds to the reorganization of the subservience/dominance conceptualization following the globalization colonialism, a force that drove Eurocentric patriarchal distortions of dominance through belief in the superiority of European minds, philosophies and economics resulting in subservience distortions and exploitations.


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The Good
The immediacy of sports journalism is so overwhelming these days that questions started to be raised about how many majors Bubba Watson will win in his career before his first green jacket was buttoned up.
It's a double edged sword. On one hand it's great to know everything as soon as possible, but it also doesn't give any genuinely great story the chance to marinate in our sports mind. We want to crown or tear down athletes in the quickest way possible, be it by blog post, tweet or Facebook status update. It's going to happen on one medium or another.
Which is why, post-Masters, I took a few days off to let Watson's victory over Louis Oosthuzien soak in and let the rest of the sports/golf media jump to conclusions and make proclamations. Honestly, it felt good to play back the tournament in my mind without the clutter of outside analysis and speculation. It's easy to take your own analysis and feelings of a golf tournament for granted because the second it ends, you've got a hundred different opinions flying at you.
I watched nearly every hole of The Masters, as is custom every year, but something about seeing Watson cry on the No. 10 green after clinching his first major championship on the second sudden death hole at Augusta was just special. It reminded me of watching Phil win his first Masters and the enjoyment I got from it while he did his awkward jump with both arms raised high.
The Masters routinely provides beauty in more forms than a cultivated landscape. Watson's wedge shot out of the Woods in sudden death on No. 10 was prettier than any of the manicured fairways. It was an updated version of Phil splitting two trees from the pine straw with a 6-iron and miraculously landing it on the 13th green in 2010. When both shots were lined up, you simply had to say to yourself, "There's just no way..." And then it happened.
Those are the lasting memories one gets every Spring from Augusta National.
The Bad
Sergio Garcia has always been an intriguing character on the PGA Tour, but I didn't think he would get to the level he's at now. He played with Rory McIlroy and as both struggled throughout the third round, it was pretty funny to see them hug and chum it up as their golf lives were in misery at Augusta.
What wasn't so light hearted were Sergio's comments the rest of the weekend:
"I'm not good enough, and today I know it. I've been trying for 13 years, and I don't feel capable of winning. I don't know what happened to me. Maybe it's something psychological. ... I'm not good enough for the majors. Everything I say, I say it because I feel it. If I didn't mean it, I couldn't stand here and lie like a lot of the guys do. If I felt like I could win, I would do it."
Well, alright then. You could tell Garcia truly meant what he was saying and after 13 years of failure and frustration at all the major championships, can you really blame him? These comments are as real as it gets and I think it makes Garcia a sympathetic figure heading into any major he qualifies for going forward. Maybe saying all of this out loud, in front of the media, is exactly what's going to get Garcia over the top, but we'll see.
The Ugly
Tiger Woods. Tiger's golf etiquette. Tiger's golf swing. Tiger's language. Tiger's ability to find the fairway off the tee. This could go on forever. He played so poorly this weekend that he had to have crushed any confidence he gained after winning the Arnold Palmer Invitational. It's still painful to watch him melt down rather than rise up, and even though I'm still rooting for him to be the best golfer in the world again, I still just don't think he's close to getting there again. Sad but true. One step forward, then steps back... and don't forget to kick your club on the way!


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The new 700 kilometre electrified train line runs parallel to the now abandoned Ethiopia-Djibouti railway. It is the first part of a vast network of 5,000 kilometres of rail which Ethiopia hopes to build by 2020.
A fleet of shiny new trains will on Wednesday begin servicing a new route from the Ethiopian capital, Addis Ababa, to Djibouti's sea port.
Landlocked Ethiopia is one of the fastest growing economies in Africa. Ninety percent of its imports and exports are transported by road to and from Djibouti across the Red Sea.
The new 750 kilometre (460 mile) railway link will reduce the current excruciating multi-day trip along a congested, pot-holed road to a smooth 10 hour journey.
"We're so excited! It takes two or three days for a truck to come from Djibouti. The driver doesn't answer his phone. We don't know where he is and that can be a bit of a nightmare," said Ethiopian importer Tingrit Worku. "The train could make a huge difference."
Ethiopia is recovering from its worst drought in half a century, which is likely to see economic growth plummet by 4.5 percent this year.
The railway line, built by two Chinese companies, is expected to benefit both Ethiopia and Dijbouti. Ethiopia will now have easier access to the sea and Djibouti will have greater access to Ethiopia's emerging market of 95 million people.
"This train is a game changer. The connection to the ports [of Djibouti] will give a bounce and our economy will grow faster," said Mekonnen Getachew, a project manager for the Ethiopian Railways Corporation.
China-Ethiopia relations
China has invested heavily in infrastructure in Ethiopia. Natural resources from Africa have helped fuel China's economic boom, and the country became the continent's largest trade partner in 2009. On Tuesday a high-level Chinese delegation signed further agreements worth $100 million for the construction of roads.
"It's the first standard gauge electrified railroad on the continent build with Chinese standard and technology, and certainly it will not be the last. Many stand to benefit from it," Chinese ambassador to Ethiopia La Yifan said in a statement.
Wednesday's inauguration will be followed by a three-month test period, with no paying passengers and carrying only cargo.
However, when the line is fully functional, uniformed Chinese controllers will welcome passengers to spotless platforms of newly built stations all along the route. Chinese technicians and stationmasters will keep operations running in the background.
"We don't yet have the management experience yet. We have a management contract with Chinese staff for five years, with an Ethiopian counterpart in training," said Getachew.
The railway is the first part of a vast network of 5,000 kilometres of rail which Ethiopia hopes to build by 2020.
"Our plan is to connect the train to Mekele [north], to Moyale [south], near Kenya, and to Gambella (west), near South Sudan. So we will be connected to Kenya, Sudan and South Sudan," said Getachew.


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Production of Procollagen by Human Fibroblasts in Culture
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Three hydroxyproline-containing proteins secreted into the medium by human fibroblasts in culture were isolated and characterized. A minor fraction was identical to the collagen monomer. The major fraction was a form of procollagen, which contained, in addition to pro α and α chains, a component estimated to have a molecular weight of 250,000. This component was a dimer of pro α chains joined by disulfide bonds. The third fraction, much lower in hydroxyproline and hydroxylysine content, was of still greater size. Pro α chains were released upon denaturation and reduction, indicating that this fraction may contain pro α chains linked by disulfide bonds to noncollagenous material.