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By (or attributed to) LrdAzrael
The following is a composite profile of an Online Predator. This profile was compiled by a number of submissive women for the use of submissive women. It is written from the perspective of a submissive female whose nature requires her to respond to a dominant male.[Sangi's Addendum: Although this text was written mainly for submissives in the BDSM (Bondage/Discipline/Sadism/Masochism) community, it applies equally well to other communities and other relationships, both online and offline. Because of the "alternative" nature of the vampiric community, as well as there being on occasion some overlap between the two distinct communities, it does tend to attract its share of predators, psychos and other unbalanced and potentially dangerous or abusive people. And although the text refers to the dominant and/or predatorial person as a "he" and the submissive and/or targeted person as a "she", these roles are not restricted to the specified sexes; that is to say, a predator may be a female, or the target/victim a male.
I don't know who originally compiled this list or where it was originally posted or published (it was posted to an e-list via e-mail, and I have so far determined that it was compiled by or is attributed to "LrdAzrael"; beyond that, I don't know). The advice given herein is invaluable for online safety.
The Online Predator
1.) Definition:
The Online Predator is one who uses the mechanisms of cyber space to hunt human beings with the intent to exploit, rob, plunder and pillage their body, mind, heart and soul.
2.) Characteristics of a Predator:
- Liar: (Self explanatory.)
- Deceiver: His self situation is presented as other than what it is.
- Betrayer: He is likely to break trust.
- Insecure: He is worried that others will be faithless.
- Inconsistent: He will say one thing while doing another.
- Lacking Honor: Usually while protesting that he has honor.
- Lack of Respect: He will tend to denigrate others.
- Transient: He is unlikely to have many long term friends.
- Manipulator: He calculates and contrives for his own benefit to the detriment of his partner.
- Secretive: He will tend to cloak himself and his activities.
- Charming: If he could not steal your breath away, he would not be a successful hunter.
- Selective: He will pick victims carefully, looking for weaknesses and filling those voids completely.
- Chameleon: He will appear to fit any need perfectly and adapt to fill any desire.
- Lacking in Self Control: Although at times, he may have extraordinary self control and discipline.
A predator probably exhibits these characteristics in all aspects of his life. It may be that the only place the predator seems to have honor and value "Truth" is in the "Relationship" he is developing with his victim. When developing a new relationship, a submissive should make a conscious effort to observe her partner's interaction with others, not just how he interacts with her. The predator may well reveal his true self through his interactions. But, the submissive may only see this revelation if she is committed to taking every precaution for her own safety.
3.) Predator Warning Signals:
While any of these phrases or actions may be acceptable in a given context, pay close attention when seeing or hearing them.
- Do not tell _ _ _ _ _ _ _ _ _ .
- ( _ _ _ _ _ ) is crazy! (or psycho, sick, a liar, or out to get me)
- It would be best if you no longer spoke to _ _ _ _ _ _ _.
- I do not need to defend myself against lies.
- They are just jealous (of me, of us, of what we have, that you have me).
- May seldom be in the D/s chat rooms. Operates from other areas or private rooms.
- Has personal information which is incomplete or not verifiable.
- Becomes defensive or angry when questioned.
- Questions the sincerity of the submissive when questioned.
- He will usually discourage or forbid the practice of reference checks.
- He will usually discourage or forbid the use of Safe Calls.
4.) The Submissive's Personal Warning Signals:
These are items that a submissive should pay attention to if she is saying them to herself or hearing them from others.
- I feel he is just too good to be true.
- You are hearing consistent warnings from more that one person.
- Your instincts are whispering "something is not right about this person".
5.) Summary:
The final best defense any submissive has against an Online Predator is her own common sense and judgment. The submissive should always remember that desires, needs, and the heat of the moment can combine to drown that judgment. Always take a moment to step back, take a deep breath and look at a potential partner with common sense and not with passion.


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Straw bale constructed homes:
This article describes a straw bale constructed home that is more than twenty years old, commenting on its construction method, durability of straw bale construction, and where strawbale home defects are likely to be observed. Our page top photo shows the exterior of a load-bearing strawbale constructed home in San Miguel de Allende, Mexico. Strawbale homes are not common in San Miguel, but are popular in many areas of the Southwestern United States.
Green links show where you are. © Copyright 2017 InspectApedia.com, All Rights Reserved.
Strawbale construction is a construction method ascribed to early settlers in the United States in Nebraska in the 1890's, and a method popular in the U.S. into the 1940's with a continuing following of straw bale enthusiasts to the present.
Prior to about 1890 straw, hay, and similar grasses were used for thatch roofing but it was the advent of the mechanical bailer using wire or twine and producing rectangular straw bales that permitted straw to be used as construction building blocks.
According to the U.S. DOE,
Straw bales were a fairly common building material in the United States between 1895 and 1940. Interest in straw-bale home construction began to re-emerge in the mid-1970s. But it wasn't until the mid- to late-1990s that building codes began to acknowledge it as a viable approach. The rising cost of conventional construction materials, techniques, and concern for our environment has fueled the growing popular enthusiasm for straw bale home construction.
There remains much we do not understand about appropriate ways to build with straw bales in different individual building assemblies, climate zones, and weather conditions. Two of the current straw bale construction methods include non-load-bearing or post-and-beam, which uses a structural framework with straw bale in-fill, and load-bearing or "Nebraska style," which uses the bearing capacity of the stacked bales to support roof loads.
Proposed straw bale structures still face considerable barriers, including the following:
The non-load-bearing construction method is the approach most regulatory authorities accept today.
To find out the building code standards for your state, contact your city or county building code officials. Your state energy office may be able to provide information on energy codes recommended or enforced in your state.
But how easy is it for a home buyer or home inspector to quickly recognize a straw bale built home? A glance at our page top photograph of a straw bale house in San Miguel de Allende, Mexico, may not immediately show how this house was constructed. But look again more closely: notice those thick walls that can be detected by the thickness shown at window and door openings? And if you (click to) enlarge the photo you might notice the "lumpy" building sides. Look again at our straw construction house wall photograph just below.
STRAW BALE CONSTRUCTION uses bales of straw tied with string or wire as the modular building blocks. Straw bales are stacked vertically in a running bond pattern - each straw bale is placed so that its center is over the end-butt joint of two bales in the course below.
The strawbales are laid either on their base (a wall thickness of about 18-22") or on their sides (a wall thickness of 14-18"). For narrow wall sections the straw bales may need to be cut and re-bound to the required length. Small and irregular wall gaps that do not fit a straw bale may be filled with hand-packed wire-mesh or wire lath forms cut to fit the necessary shape.
"Straw" is defined as the stem portion of a grain plant such as the stalks of barley, oats, rice, rye, or wheat, but without the grain (seeds) or grain "heads" of these plants.
Strawbale walls are normally, reinforced with through-driven or surface-tied wood, bamboo, or steel re-bar rods, and then coated on all sides with a stucco of earth, clay, or a cement mixture, applied either directly to the straw bale wall surface or applied to a "chicken wire" mesh or to clay-coated burlap that has been tacked to the surface of the bales or to the reinforcing bamboo on the wall exterior surfaces.
Strawbale wall plastering may be performed entirely by hand, or the builder may use a textured-paint sprayer to first prime the straw wall, making subsequent plaster coat application easier and providing a better bond. During plastering of the strawbale wall, a "cob" mixture of straw, sand, clay and water may be packed into any small remaining gaps between the bales. The straw bale wall plaster recipe varies by location and available materials.
The plaster first coat may be an 80-20 mix of sand and clay with chopped straw added for additional strength.
The final plaster coat, hand troweled, may also be an 80-20 sand/clay mix with an addition of 4% lime water. This coating will contain less chopped straw or none at all in order to give a smooth hard finish on the wall. Finish coating with lime plaster or similar materials may be applied depending on the climate and building use. For building durability proper curing of the plastered or stucco coatings and final lime or pigmented coatings is very important as hairline cracks can invite moisture into the structure, destroying it.
Post and beam-constructed straw bale homes use straw bales to fill in the wall spaces between wood, reinforced concrete, or steel posts and beams that form the structural frame for the home. The frame supports the weight of the building roof and upper floors. In post and beam strawbale construction the courses of bales may be pinned together using vertical lengths of bamboo (two to a bale) placed on the inside and outside of the straw bale wall, then tied together using a stiff wire "needle" to force twine through the bales where necessary.
Load-bearing-wall-constructed straw bale homes are built using courses of straw bales that themselves form the supporting wall structure for the building. Strapping over the top course of straw bales is (or should be) carried to connections that pin the wall to the building foundation (if a foundation is provided). Some straw bale homes are built without a masonry foundation, resting the first course of straw bales on compacted earth or gravel.
Our photograph (left) shows the sides of a straw bale built home. The "lumps" visible on the building wall are about the size of a bale of hay or straw - we call this modulo-straw-bale lump size, an obvious indicator of the materials of which this home was constructed.
This straw home photo (left) shows the interior of part of this two story home. Here, too, when the angle of illumination is just right, it's easy to see the straw bale texture of the home's walls. Of course other straw-bale constructed homes may be parged to a smooth wall surface, hiding this straw bale shape.
We have read assertions that well-constructed straw bale houses in Nebraska have lasted for more than 100 years. But as with any construction method, the life expectancy of a strawbale home will depend on both the quality of its original construction and the quality of maintenance over the life of the building.
The type of straw used to produce bales used in strawbale construction may make a difference in the durability of the building. Straw may be comprised of the stalks of barley, oats, rice, rye, or wheat. But the higher silica levels in rice straw make it easier to dry and more resistant to decomposition from moisture.
In the home shown in these photographs, the strawbale constructed home uses load bearing straw bale walls. The load bearing design may be a significant factor in the appearance of the wall cracks and leaks shown in our straw bale wall damage photographs (below).
Our OPINION is that non-load bearing straw bale construction (in which straw bales are used as infill between the posts of a wood, concrete, or steel post and beam structure) may be less likely to experience these problems. The walls of a load bearing straw bale home must carry not only the weight of the wall material itself but also that of the roof and of the live and dead loads of upper floors in the building. Any condition that increases the chance of cracks in the stucco coating of the straw bale wall increase water, insect, and rodent penetration risks and thus the chances of further rot, settlement, or infestation in the structure.
The window in our photo (below left) shows the wall thickness - a clue that this is a straw bale home. The outside of the window jamb was painted green, the inside white. A good outdoor construction detail on a straw bale home of this design is the inclusion of a slope on the window sill so that it drains without risking sending water into cracks in the straw bale stucco coating. Our second photo (below right) shows one of the places to look for cracks, leaks, and water entry at a straw bale constructed home - at the window and door openings.
Our photo at above left shows a thin vertical crack in the stucco covering of this straw bale home, at the center of this picture.
Our second photograph of a straw bale home (above) shows both cracks and evidence of previous repairs in that same location (click these photographs to enlarge and make the crack details more visible). Just below are closeup photos of cracks in the stucco coating of this straw bale constructed house wall.
It has been very useful to have stumbled upon your website as I had no knowledge of straw bale construction and its special care requirements. Since you offered some support, I would like to ask you two things. As you know the house is old. It was built specifically for rental and the quality of most materials, such as window and door framing, and furnishings is below what I prefer in a home. It has potential, though.
Last summer I noticed that a small section (maybe 10 cm.) of an exterior apartment wall had cracked and was open to the elements. I did ask my property mamager to repair it, but I don't know if she is aware of the construction material. So question one is how easy or difficult is it to repair a small section like that?
The second question is how easy or difficult is it to cut a new door or window into an existing wall, as I someday want to put a room addition on the lower, one-story apartment. - N.G., Myanmar
Think of the straw bale wall structure as a thin masonry shell plastered over bales of hay or straw. If water gets into the interior of the shell it invites decay or pests that over time can damage the bales, leading to hollow areas that are structurally weak compared with the as-built design. So my opinion is that it would be smart to inspect the house from time to time and to try to keep any cracks you see sealed.
Typical repairs to straw bale house cracks are simple re-plastering, or chipping open a crack wide enough that the plaster repair will be mechanically sound, then re-plaster and re-paint the wall.
By "re-plastering" I refer to using a cement mix, not actual "plaster". The crack may need to be opened a bit wider and cut to an inverted "vee" shape to get the best mechanical adhesion of the patch. Very fine cracks in the straw bale stucco coating, say less than 1/16" in width, might seal up ok if kept painted.
If you find actual damage that is resulting in movement of the structure - say crushing under a floor joist or beam - then it would be appropriate to open the wall to see what's going on.
It would be simple to add a post and pier if necessary, you don't have to chop open the whole wall and try replacing bales. But if you are not seeing structural movement, that more extravagant repair should not be necessary - just keep cracks sealed as best you can.
I'm more nervous about cutting openings for windows or doors, especially when both of us are just thinking by email and are not on-site to see exactly what's going on and exactly what is inside of a wall that we cut open. In general, a too-glib answer is that you can do just about anything to any building - that is it's possible.
The devil is in the details: just how much trouble and expense are we going to face, and are we sure we're handling the change with enough thought that we're not messing up the rest of the structure.
If you cut a door where there is already a window, often that's pretty easy as there is already a header over the window opening to carry the weight of the wall above. So if the top of the window is high enough to fit a doorway, just cut the bottom wall out below the window. It's not going to change the structure.
But if we need to make a new opening where there was none, most likely you'll want to frame in a header beam to be sure there is no sagging or cracking in the wall above. The header is carried on posts to concrete piers poured into the soil deep enough that there won't be any sinking and thus there won't be any cracking in the wall. Then the door or window jamb is framed into that opening.
Finally, if by chance a neighbor can tell you who built the straw bale home, we might find out if the original builder is still around, as s/he will also be familiar with hidden structural details in the home and somewhat familiar with straw bale construction. A clue would be whether or not we can find any other such homes in the neighborhood.
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subset: commoncrawl


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Wednesday, June 23, 2010
How could there be day and night before the sun was made?
Presumably, the same way there will be in the renewed creation:
"They will need no light of lamp or sun, for the Lord God will be their light, and they will reign forever and ever." Revelation 22:5
Jesus is The Light of the World, the one who shines out from his Father, the one who said "Let there be light". Having established light in the dark, he then makes the sun and moon, appointed to rule on his behalf, reflecting His light - overwhelmingly in the day, and reflecting that in the night so that the light always shines and the darkness never quite wins (just as the church reflects Christ in the world today)... so too humanity is appointed to have dominion on behalf of Christ, imaging his benevolent rule. Shadows of the life of God.
Why create this way? Because this is what he would do in the pitch darkness of the human heart. As in salvation, so in creation - because this is who the Triune God is. This is how the universe had to be because of who God is. And ok I don't quite know how the physics of all this works, but Scripture is internally coherent enough, it's just very different to how people think when they presuppose that the Triune God doesn't exist.
7 comments:
Bingo! Dead right methinks.ReplyDelete
The simple explanation is that the people who wrote the text just didn't know that the sun was the source of light.ReplyDelete
Sripture, in this instance, is not at all coherent. But then why do you want it to be?
"The simple explanation is that the people who wrote the text just didn't know that the sun was the source of light."ReplyDelete
That would be a simple explanation, but it is not true. Hebrew culture did not grow up in a vacuum, and it was well known in other ancient near eastern cultures (Egypt and Babylon are the ones I know most about) that the sun produced light. Hence the worship of the sun-disk in Egypt as Aten, and in Babylon as Shamash, and the frequent connection that is made between the physical light produced by the sun and the moral/legal light cast by the associated deity. The Biblical authors are aware of this tradition - it is widely thought that the author of Gen 1 does not name the sun (it is just the great light) precisely to avoid implications of deity. Add to this the fact that ancient Hebrews were just as capable as you and I of empirical reasoning ('it gets light when the sun comes up and gets dark when it goes down'), and I don't think there can be any doubt that the same author knew very well that physical light came from the sun, and deliberately constructs his narrative to make a theological point.
Whether we should ask 'why create that way?' or 'why write up the creation that way?' seems a more pertinent question, but doesn't impinge on Dave's point.
Thanks for the response Daniel. I read Dave's post as implying that there literally was light from some source before the sun was created.ReplyDelete
If, as you say, the author just had theological reasons for telling his story that way, despite knowing that it wasn't factually correct, then I would agree that there is no issue, and no need to demand coherence from scripture.
One might ask, does this correspond to reality, but you can't really argue that Scripture isn't internally coherent on this. Jesus is consistently the dominant light, and the sun, moon, stars are lesser lights to him - such that in the re-created heavens and earth he will be the light not any of the lesser lights.ReplyDelete
Like I say in the post, how you figure the physics is another question. And each of us has our "creation stories" that explain origins based on our assumptions. And if you exclude the existence of The Triune God who created the world then you definitely need an alternative to Genesis 1 in all sorts of ways.
Didn't you just add the word "internally" to your original post? Perhaps you might have, honestly, mentioned that when you did it?ReplyDelete
Anyway, even with your new spin on the question, who cares if scripture is internally coherent on this issue of light existing before the sun was created? Wouldn't it be preferable if it was coherent with reality?
I did add the word internally not to say it's not externally coherent too, but to challenge your notion that it doesn't even make sense internally - which it really does, the Bible is a perfectly consistent piece of literature.ReplyDelete
I also happen to think it offers at least as compelling an explanation of origins as any of the other popular creation stories being believed in society today - though as I said, quite how you'd work out the physics of that I'm less sure, but there are some big holes and major assumptions being made in popular science too.


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Beautiful Kitchens & Cabinetry can be found at E Milton Ave 29. The following is offered: Lumber & Wood Products. The entry is present with us since Sep 9, 2010 and was last updated on Nov 14, 2013. In Rahway there are 1 other Lumber & Wood Products. An overview can be found here.
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Hahn Loeser's Cleveland office is located in one of the most recognizable buildings in downtown Cleveland. At the time of its construction, our building was the second tallest in Cleveland, only six stories shorter than the Terminal Tower. Designed in the early 1980s by Gyo Obata, of the St. Louis architectural firm of Hellmuth, Obata and Kassabaum, Inc., the building cost $200 million and featured more than 1.5 million gross square feet. Originally designed as the "Sohio Tower and Atrium," the building was intended as a symbol of leadership for The Standard Oil Company which was founded in Cleveland in 1866 by John D. Rockefeller, the first self-made millionaire in history.
Phone: 216.621.0150
Fax: 216.241.2824


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As women themselves, Hobo understands what it takes to get there. That's why all of Hobo's products have unique details that make the journey easier. Organizational pockets, security zippers, sturdy straps, functional spaces and lightweight materials are some of the features that make Hobo products distinctive and versatile. Confident styling, edgy attitude, quality construction and practical features are the hallmarks of their designs.
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The muted pinks and blues of the Flower Mosaic Visa Gift Card suggest it would be a wonderful baby show gift when you don't know whether to buy for a baby girl or boy. The collage of overlapping patterns has a mesmerizing effect on the eye that is both intriguing and relaxing. Express yourself with Mosaic Visa Gift Cards for any occasion.
The Visa Gift Card can be used wherever Visa debit cards are accepted.
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Happy Birthday Capricorn! Your season is notorious for puffy coats, runny noses, dry air and SNOW! And you… You are notorious for being ambitious, calculated, independent and bossy. You're also hilarious, but in a cynical, I've-seen-it-all manner. We also know that when you party, you can show everyone else how it's done! There is so much more to you, though, that other people don't know because astrologers don't acknowledge the other traits! Sharpe Astrology has your back, and we would like to acknowledge the Capricorn traits that you might feel are under-appreciated.
When in a relationship, you carry a torch around for that person until the flame completely dies out.
The thing about you in relationships is, when you love someone, you want to provide for that person in any way possible – emotionally, physically, socially and financially. That being said, the pressure of being everything to someone can really get to you! Your emotions can be masked by all the pressure you feel to provide for others, which can harden your surface at times. Deep down, we know you are a a softie. When you love someone, you adore most things about that person. Even when this person hurts you, you find it in yourself to appreciate everything else about your relationship. And you will do this until your relationship is 100% over.
You go beast mode at work when you have things on your mind.
When you have issues on your mind, your head spins at least 100 miles per hour. You're a problem-solver by nature… You don't idly watch things unfold or let your problems fade away. Generally, people feel stuck at work when they have things to take care of. You get that way, but that doesn't stop you from being productive. So much energy builds up inside you when you can't do anything to fix issues at the forefront of your mind. So what do you do with all that energy? You apply it to whatever you are doing. In fact, you work even harder and faster than usual. It makes the time move faster, and it even helps you escape from your thoughts for a little bit.
In times of crisis, you stay cool as a cucumber.
When everyone around you is in a panic, you take a minute to brainstorm. Don't get me wrong – you are fast to act. However, you know that you can come up wth the best action plans when you withdraw into yourself quickly. By doing so, you can heighten your awareness above your surroundings. And that is what people need more of.
When you are responsible for other people or animals, providing for them is your #1 concern.
Want to know one of the cutest sights to see? Watch a Capricorn interact with an animal or a baby. Everyone loves seeing a professionally-driven and well-composed person turn into mush over someone or something cute. When you have a furry one or another person to care for, they become your priority. You want to be sure that you fulfill their needs because happiness begins with stability, and happiness puts smiles on their faces.
You willingly carry out sacrifices for the ones you love.
It takes a lot for you to really care about someone. When you feel this way for someone, it is because you see this person as truly special and unique. Your love runs so deep that you do what it takes to help your loved ones, even if it means giving up your wants and even some of your needs.
The people you surround yourself with come from all walks of life.
You can come from any background or live in any setting. You can even be sheltered all your life, but nothing stops you from becoming acquainted with good people from all walks of life. Your circle of friends can include people from all over the world, and people with very different lifestyles from you and each other. One thing that they all have in common? They would be there for you in times of need, because you would do the same for them, and you have probably proven that already.
You love problem solving.
As a builder of the zodiac, it feels good to make the best of whatever resources you have. So, when a problem arises, you are quick to step up to the plate with solutions. Additionally, you enjoy playing devil's advocate, but not to be a dick – you do it because you want to make sure that when decisions are made, the best option is chosen.
You climb to success as quietly as possible.


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When it comes time to evaluate your office space options, your broker should provide a complete market evaluation of property options that best fit your detailed criteria. Ultimately you are going to make the best real estate decision based on numerous factors including; location, economics, the quality of the building and its amenities, as well as the reputation of the Landlord.
However, when it comes time to inspect various space options and physically tour buildings there are a several tips to keep in mind to: (1) help you in the evaluation of specific properties and (2) insure that you do not undermine your tenant representatives positioning in the upcoming negotiations.
Limit your scheduled tours to 3-4 properties: If you are going to tour more than 3 or 4 properties, then if feasible break the scheduled space tours up into different days. After three or four building / space inspections the exercise begins to feel tedious and there is a tendency to lose attention and forget details after several hours of repeating the process.
Let the Landlord's leasing agent make his presentation: It is the Landlord's leasing agent's job to present his building and show you various space options within in the building and highlight all the features and amenities of the project. Let the agent make his pitch, learning as much as you can about the property, then it is appropriate to ask key questions. Furthermore, your tenant representative shouldn't feel the need to unnecessarily demonstrate all of his knowledge during the building tour resulting in overshadowing the building leasing agent.
Have a list of key questions to ask: Review with your broker prior to building tours the key questions to ask of the leasing agent or owner's representative. You may want to inquire about specific building amenities, services and policies of operation that are important in your selection process. This could be food service, security, after hours HVAC, fiber availability or a variety of different issues.
Keep a poker face: There is nothing worse for your broker's negotiation position than to have your staff or management team running around the premises assuming ownerships of the space, as if it's the obvious choice. Even if you have found the perfect space in the perfect building in the perfect location, attempt to bridle your enthusiasm. There is nothing wrong with making a statement regarding the property being feasible, but do not tip your hand that a particular building may be a clear front-runner. Also, it is probably a good idea to keep space tours limited to key staff involved in the selection process.
Check out the public restrooms and common areas: In most cases the landlord's leasing and property management team has the opportunity to prepare for the space tour but a routine check of the restrooms and common area for cleanliness can make a statement about the property management services.
Drive through the parking garage: In many cases when you visit a building you are going to park in the designated visitor parking area which is typically very convenient. However, if you lease space in the building this is not where you are going to be parking every day. Check the parking garage for ease of ingress and egress and overall ease of use.
Go back to the building at the beginning and end of the work day: A good time to evaluate the location of the building is at peak traffic times. Is traffic around the building a complete nightmare at the time everyone is arriving for the workday or leaving. Does the building provide building security staff or off-duty law enforcement for directing traffic in and around the building at peak times?
Review the building directory: It is prudent to evaluate the other tenant's of the project. Is there an undesirable tenant or direct competitor located at the property? Also, a scan of the building directory may reveal a company you know which can ask for an unbiased recommendation or opinion of the building, property management and ownership.
Do not reveal any key information: The Landlord's leasing agent knows he is going to compete for your tenancy. The well trained landlord agent is going to ask inquisitive questions to establish his relative competitive advantage or disadvantage. If asked, you can simply instruct the landlord's agent to direct all questions to your broker.
Make it clear you are looking at other properties but don't reveal which ones: This can be accomplished in a subtle way by bringing your tour package your broker has provided so it is apparent your are looking at multiple properties, or your broker can make a simple un-revealing statement that you are considering multiple properties. Many leasing agents will ask directly what other properties you are looking at. The best policy is to just refer that question to your broker.
Do you have another tip to add to the list? Leave me a comment if you have a suggestion.
You might also like:
25 Articles for a Better Office Lease
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Brooks v. Lincoln National Life Insurance Company, et al
8:05-cv-00118 | Nebraska District Court
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- Get up-to-date information for this case.
- Download all documents.
- Docket alerts when there are new filings.
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List of referrals
A new "
The new "Referrals" section enables partners to track the changes in the number of their referrals and view a complete list of all their referrals, including IDs and links to the profiles of referred users.
Referrals are users invited by a partner. That is, the referrals of the "Master Tigra" team are users who joined the projects of the "Master Tigra" team thanks to a partner's efforts (placement partner applications, referral links, etc.). The partner in this case is called the referrer.


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The next step is critical: Taking the facts and figures and developing a big-picture view of what they mean and what opportunities the represent. Our company reports don't require a PhD in Economics or a Series 7 license to understand or interpret. From veteran investors to novices, they are written in a way that the research makes sense and helps guide you to better decision making in your trades.
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Cambridge, MA (PressExposure) December 01, 2011 -- AIP Publishing, a division of the American Institute of Physics (AIP), and Publishing Technology plc (LSE: PTO) announce a partnership to build the next generation of AIP's Scitation, scheduled for launch in the fourth quarter of 2012.
The new custom platform will be developed using Publishing Technology's pub2web hosting solution, enabling AIP and its Member Societies to house an impressive portfolio of journals and conference proceedings as well as Physics Today magazine and historical documents from AIP's Physics Resources Center.
"With our strategic shift to concentrate our resources on serving our readers, authors, librarians and our Member Society publishing partners, we are excited to find an impressive partner to deliver the best possible way forward," said John Haynes, Vice President of Publishing at AIP. "Enhanced functionality, discoverability and customer experience are paramount in our business and Publishing Technology has the international expertise to provide the first-class infrastructure our readers expect."
Designed to put users at the center combining a flexible and extensible architecture with sophisticated information commerce, leading-edge semantic technology and industry standards, the pub2web interface will provide the research community with new opportunities for collaboration and discovery. During the design phases, the user community will be engaged through focus groups, dialogue, training and usability testing. Authors, readers and librarians can expect a seamless transition, new interactive communities and an overall enhanced user experience tailored to their specific needs. According to AIP's Chief Information Officer Evan Owens, "Publishing Technology's pub2web hosting platform will provide the foundation for the AIP collection of specialized physics-related content with a rich array of semantic features as well as deliver industry-standard support for the needs of library and individual subscribers. We look forward to working with the company's development team to revolutionize the user experience."
Louise Russell, Chief Operating Officer of Publishing Technology's Online Division, offered, "We are excited by the prospect of providing AIP and its Member Societies with the technology to take their digital strategy to the next level. Focusing on the needs of authors, readers and librarians to deliver new, personalized discovery routes into content will break down traditional silos and allow for experimentation and added value. By bridging multiple content types from multiple member publishers and extending their reach, the new Scitation will be a premier research destination on the Web."
About pub2web
The pub2web platform is a customized, multi-content publications portal-delivering all the functionality needed to support evolving online strategies and to satisfy the user base, however diverse their needs. Customers benefit from proven, regularly-updated technology while also maintaining full control of their brand, their content and their user relationships. It allows customers to help their users to explore all their content - whatever its format - with progressive browsing options driven by pub2web's award-winning data storage and modeling. Visit http://www.publishingtechnology.com, follow on Twitter @publishingtech, or connect on LinkedIn.
About AIP
The American Institute of Physics is an organization of 10 physical science societies, representing more than 135,000 scientists, engineers, and educators and is one of the world's largest publishers of scientific information in physics. AIP pursues innovation in publishing of scholarly journals and offers publishing services for its Member Societies. AIP's suite of publications includes 15 journals, two of which are published in partnership with other societies; magazines, including its flagship publication Physics Today; and the AIP Conference Proceedings series. Through its Physics Resources Center, AIP also delivers valuable services and expertise in education and student programs, science communication, government relations, career services for science and engineering professionals, statistical research, industrial outreach, and the history of physics and other sciences.
Visit http://www.aip.org, or follow on Facebook or Twitter @ AIP_Publishing.
Distributed on behalf of Publishing Technology by NeonDrum news distribution service (http://www.neondrum.com)


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Monroe is an easygoing puppy that will fit into many types of homes. He is great in a working home with 3 kids ages 10, 8, and 7 plus a newfie and another cocker. He has a great "willing to please" attitude which will help him adjust into your family quickly. He follows people and dogs around, sleeps with his family and is very friendly. He knows to sit and walk on a loose-leash. He will probably show more of his puppy like tendency once fully acclimated into a new home. He chews on appropriate dog toys and sits like a person in a car. He will be a great addition to your home.
If not already, Monroe will be micro-chipped, neutered (if age appropriate), and up-to-date on his shots prior to adoption. If you would like to meet Monroe to see if he is a good fit for your home, please fill out an Adoption Application online.
• We cannot guarantee the age and breed of any dog. We depend on licensed vets and other professionals to provide the best determination, unless the dog arrived with written documentation.
• Puppies not spayed/neutered at the time of adoption due to age will require a $50 refundable sterilization deposit in accordance with Colorado Code of Regulations 8 CCR 1201-11: Part 19-J.
• We reserve the right to refuse an adoption to any person for the well-being of the dog.


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CISF Training Centre in India
All applied candidates will present in the CISF exam in upcoming days shortly which will be operated on prescribeddate by Central Industrial Security Force at various centers. Applicants who are going to participate in the exam of CISF they must well & exact preparation for CISF examination to crack this examination with high level marks therefore we are advised to join CISF Training Centre to obtain good preparation of CISF examination. In below section of this page we are providing you some CISF Training Centre in India with the address of the Centre, Phone/Mobile and website to choose the best coaching centre by applied contenders to take related knowledge for exam of CISF. Dear applicants, you must visit Coaching Centers from below section of this web page to get well preparation for CISF examination & join best center.
CISF examination will be conducted for whole candidates, who have applied successfully & want to get job in Central Industrial Security Force. Job seekers, who are eligible to appear in the exam & they want to well preparation for examination of CISF, can check CISF Coaching Centers from this page.
Short Details of www.cisf.gov.in Training Centre in India
Exam Held by – Central Industrial Security Force
Name of the Exam – CISF
Page Include Information about – CISF Training Centre in India
Official Website - www.cisf.gov.in
Best www.cisf.gov.in Coaching Centers / Academy
Please have a look at -
Sea Study Circle, Secunderabad
Phone/Mobile +91 40 33695928
Address No. 9-2-171/4, 2nd Floor, Rezimental Bazaar, Hilton Hotel Building, Secunderabad, Hyderabad - 500003
Pace Academy, Abids
Phone/Mobile +91 40 33684159
Address No. 201, 2nd Floor, Mayur Kushal Complex, C Block, Abids, Hyderabad - 500001
Land Mark: Beside Chermas Cloth Showroom
Career Matrix, Uttam Nagar
Phone/Mobile+91 11 40016777
Address WZ/B-39, 1st Floor, Main Nazafgarh Road, Uttam Nagar, Delhi - 110059 [Get Direction]
Land Mark: Opposite Metro Pillar No. 651 Near Uttam Nagar East Metro
Emailhelp @careermatrix.info
Website www.careermatrix.info
Xpert, Narela
Phone/Mobile 7503757578, 9990124451
Address Frist Floor, Op Extion Show Room,, Narela, Delhi - 110040
Land Mark: Near Bus Terminal
Delhi Police Training Institute, Wazirabad
Phone/Mobile 011 - 22963084
Address No. 1, Wazirabad, Delhi - 110054
Land Mark: Near State Bank of India
See Now: Easy Tips to check a result online
Note: If applicants want to know more about CISF, can visit Official Website.
CISF Updates & Preparation Material
Take a Look on Below Table
|Latest Government Jobs
|Engineering Jobs
|10th/12th Pass Jobs
|Graduate Degree Jobs
|Police Jobs in India
|Latest Employment News
|Rojgar Samachar
|Tips to Download Admit Card
|Written Exam Tips
|Career Management Tips
|English Improvement Tips
|Interview Tips


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Unusual vintage solid wooden dresser with inlaid detail and cast brass hardware. The back right foot in off, but can be reattached. Price includes reattaching the foot at no extra cost. Please inquire for more photos.
The dimensions are: 33.75 in. H x 72 in. W x 22 in. D, 168 lbs
**NOTE: Before purchasing directly through PayPal, please inquire about item availability and please wait for invoice to be emailed to you BEFORE paying directly. Often, an item has been sold quickly & not taken off yet or shipping prices have to be adjusted. Thank You!
Another shopper has this item in their Cart or Wish List .
Your source for Architectural Antiques & Altered Antiques
Industrial, altered antiques, doors, hardware, farm tables, tin mirrors and panels and mantels.


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Syrtis-sid is the professional integrated library system.
Syrtis-sid was developed by library and information-science specialists, while at the same time addressing known existing needs.
Syrtis-sid allows to take into account the growing needs of library science:
- FRBR cataloging
- RDF, OAI publishing
- manage interfaces with other formats
- manage access rights and roles
- manage users
- manage document circulation
- lending and returning
- access to documents in-store and on stacks (in-situ, on carrel desks…)
- rules and fines
- digital loans
- copyright management
- purchasing
- supplier management
- order management
- accounting
- journal management
- thesaurus management
- dashboard
- work planning management
- stats
Based on a modular architecture and innovative technologies, Syrtis-sid addresses current and future expectations of library-science professionals and IT departments:
- module settings
- multi-site management
- optimal performance with innovative technologies (big data, nosql…)
- application security management (OWASP norms)
- improved ergonomics for a better comfort (touchscreens, responsive design)
- full web
- compatible with all OS
- available as SaaS, Cloud-computing
Information-sharing and cataloging processes are facilitated thanks to a pooled data management.


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Showcasing a love of nature and carpentry to create amazing stick sculptures, this video, 'Inspired By... Patrick Douglas,' is captivating. These extremely striking tree branch sculptures are a spectacle to look at, and involve an extremely intricate building process that is something to behold.
Douglas works together with various volunteers to to build these sculptures, which are made out of thin tree branches. Douglas bends and shapes the branches into unique positions that are meant to be "galvanizing shapes that get attention."
Shywood Eyewear and Experimenting With Nature have come together to present the video series seeks to showcase some of the artists, engineers, musicians and architects living in the Pacific Northwest area of Portland.
Unpublished - Old
Colossal Stick Sculptures
More Stats +/-
Human Tree Hybrid Illustrations
Wild Woodsy Homes
Pixalated Magazine Sculptures
Household Trash Animal Sculptures
Stinging Sandy Sculptures
The 'Inspired By...Patrick Douglas' Video Sculpts Beauty From Branches
- By: Cody TurnerJul 31, 2012
References: stickwork.net & vimeo
References: stickwork.net & vimeo


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Once you own a digital SLR, a high quality lens is exactly what you need to take more gorgeous pictures. That's why we only sell the best lenses to you from Canon, Nikon, Tamron, and Sigma!
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- Once ordered, we will call you the same business day and let you know when your lens should arrive. If you choose to cancel the order when we give you an estimated shipment arrival time, it is fully refundable.
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Canon EF 50mm f/1.8 II Lens
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Canon EF 75-300mm f/4-5.6 III Lens
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- Ultra-light lens body
- At 300mm, shoots as close as 4.9 ft
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- More affordable lens similar to its USM counterpart


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Thanks to jkOTR reader, Hector, we got a peek at what appears to be the official and forthcoming Sprint 6800 PDF spec sheet. The most important tidbit about availability isn't there, but mid-May appears to be the buzz around the Internets these days; still nothing concrete about Verizon's ETA. Let's get a refresh and confirmation on the features:
- Windows Mobile 5 (initially as I believe there is a WM 6 upgrade in the plans)
- A Qualcomm MSM7500 mobile processor rated at 400 MHz
- 256 MB ROM & 64 MB of RAM
- Semi-standard 2.8-inch QVGA touchscreen
- 2 Megapixel camera
- EV-DO Rev A. upgradeable (sounds like Rev 0 at first to me), Bluetooth 2.0, 802.11 b/g
- Slideout QWERTY keyboard
For XV6700 / PPC-6700 owners, the big upgrades are the Rev. A EV-DO, internal antenna and camara res boost. Of course, with no official word from Sprint (or Verizon), price and availability details are still hiding in somebody's desk, so stay tuned. Thanks Hector!


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Tuesday, April 11, 2017
Kinzd 3 Wallet Review! The Magnetic Money Clip, Leather Slim, Minimalis...
Kinzd 3 Wallet Review! The Magnetic Money Clip, Leather Slim and the Minimalist Wallet!
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Johnny Bravo: Date O Rama! for Nintendo DS
Cartoon Network's musclebound, pompadour-sporting Johnny Bravo gets another chance to woo the ladies in his first dedicated video game. Players join the self-styled Lothario as he heads to the hits game show "Hukka Mega Mighty Extreme Date-O-Rama" to compete against rival studs. Gamers can help Johnny impress the ladies by taking on eight different events, including "Strike A Pose," "Food Fight," and "Disco Dance-Off." Players can also unlock clips from the show, classic one-liners, and special postcards.


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Looking for a job? Trying to find a date? Looking for an apartment? Browse our classifieds. Have a job to advertise? An apartment to rent? Post a Classified Ad.
Category: SS Condo Rent
Longport RentalLongport Rental-Incredible Ocean Plaza Condo Ocean Plaza-27th and the Beach. All New Building! 2 BR, 2 BA. Spectacular 6th floor views with huge outdoor terrace.


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XXL Antler Necklace 7
Long Ivory Howlite Beaded Necklace with Deer Antler. The perfect finishing touch for this season's boho look and you will definitely get noticed.
Each necklace is hand crafted and comes with a naturally shed deer antler. Please note that each necklace is made to order and may take up to 2 weeks to ship. Due to this item having a natural antler, each antler will be different from the one in the photo. No Animal was harmed in the making of this item.


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The Sin_Episodes_Emergence_PSP.mp4 file you have requested: Media / Videos and Trailers / Official Videos / SiN Episodes: Emergence PSP Trailer - 24.71mb is not available. Perhaps try browsing all files for the game SiN Episodes: Emergence and upload any files you want to share or are missing. This is the only information we could locate:
A PSP trailer that runs for 2 minutes and 50 seconds and shows plenty of in-game footage for SiN Episodes: Emergence Trailer.
We recommend you return to the download list and browse the links from there. If the problem persists, contact us with the details.


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Research in DBA?. Josu de la Fuente St Mary's Hospital Imperial College London. A Genome-wide Approach to Investigate the Mechanism of Glucocorticoid Effect on Erythroid Progenitors in Diamond- Blackfan Anaemia. Leukaemia & Lymphoma Research November 2012 Value: £221,922
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
Josu de la Fuente
St Mary's Hospital
Imperial College London
Leukaemia & Lymphoma Research
November 2012
Value: £221,922
DD McPhail Charitable Settlement
Value: £35,000
NGS Award, Imperial College London
April 2011
Value: £30,000
Diamond Glucocorticoid Effect on Blackfan Anaemia Patients Have a Higher Rate of Hepatic Iron Accumulation than Thalassaemia Major Patients Leading to Fibrosis
Katharine Evans1, Robert Goldin2 and Josu de la Fuente1,3
1Division of Haematology, Imperial College London London, 2Division of Histopathology, Imperial College London and 3Division of Paediatrics, St. Mary's Hospital, London, United Kingdom
Background and Aims
Diamond Blackfan anaemia is an inherited bone marrow failure syndrome with haematological and systemic manifestations. The classical presentation of the condition is the development of anaemia in infancy, which occurs in approximately 85-90% of the patients. Long-term 40% require transfusions as they fail to maintain erythropoiesis at acceptable doses of steroids and only approximately 10% of the patients go into remission. In the cohort of 64 patients who attend the specialist DBA clinic at St. Mary's Hospital, London, we have identified that iron overload is a significant clinical problem, even when receiving adequate chelation treatment with current guidelines and at a young age (Poster #1268).
To investigate the iron load caused by transfusions and its effect we studied the liver biopsies of 13 patients with DBA and compared them with 27 patients suffering from thalassaemia major (TM) (Table 1). The findings were correlated with the number of transfusions, chelation treatment, ferritin level and MR techniques. Image analysis of the degree of fibrosis was performed using NIS-elements software after staining liver biopsy slides with Sirius Red (Figure 1).
TM patients were significantly older [median age: TM 9 years (3-18), DBA 5 years (1-15); p=0.004], which was also reflected in the duration (months) of transfusion [TM 105 (12-198), DBA 52 (12-130); p=0.004]. However, there was no difference in the frequency of transfusions (p = 0.51) and in the length of time (months) between starting transfusions and chelation (TM 19, DBA 27; p=0.08). DBA patients received proportionately more chelation per transfusion than TM patients at the time of biopsy (proportion of chelation time to transfusion time: TM 1.24, DBA 1.58; p=0.015). Ferritin levels were higher in TM patients, though not significant [TM 2028 g/L (1292-4901), DBA 1324 g/L (535-2300); p=0.16].
Despite having significantly fewer transfusions, the grade of iron deposition was higher in the DBA group (TM 2, DBA 3; p=0.035). This was also reflected in MRI T2* quantitation, which demonstrated a higher hepatic iron load in DBA patients [TM 3 ms (1-12), DBA 2 ms (1-3); p=0.59]. The rate of biochemical iron accumulation (mg/g DW) for every month of transfusion was significantly higher in the DBA group (TM 0.05, DBA 0.11; p=0.005). The rate of fibrosis accumulation was 60% higher in the DBA group, although this was not statistically significant (TM 0.1, DBA 0.16; p = 0.07) and could be due to a time lag between iron accumulation and fibrosis formation, particularly as the DBA patients were younger and had had shorter follow up (Table 2). Biochemical iron, ferritin level and MRI T2* had low, significant correlations with fibrosis in TM patients (0.547, p=0.001; 0.357, p=0.033; -0.430, p=0.011, respectively) and FerriScan in DBA patients (0.75, p=0.05) (Table 3).
In conclusion, DBA patients have a higher rate of iron accumulation with a trend to higher hepatic fibrosis.
Male cell in bone marrow adherent culture
Male cell in bone marrow before culture
CD45+ male cell
Vimentin+ male cell
Table 3.Correlation between iron accumulation measured by different techniques and fibrosis formation in TM and DBA
Biochemical iron, ferritin level and MRI T2* had low, significant correlations with fibrosis in TM patients and FerriScan in DBA patients.
Table 1.Patient characteristics
TM patients were significantly older and had received blood transfusions for a longer period of time reflecting the different referral pattern for both diseases to our institution. TM patients are referred for specialist advice of chelation treatment and consideration of bone marrow transplantation. DBA patients attend the specialist DBA clinic (n=64) from the moment of confirmation or strong suspicion of diagnosis. However, DBA patients received proportionately more chelation per transfusion than TM patients at the time of biopsy .
Figure 1. Fibrosis image analysis using NIS-elements software
Image analysis was performed using NIS-element software. Slides stained with Sirius Red were photographed using the software at a magnification of 4x/0.10. The software was programmed to differentiate background (white), hepatocytes (yellow) and collagen (red) and the percentage of the are representing collagen was calculated.
Table 2.Rate of iron and fibrosis accumulation in TM and DBA
The rate of iron accumulation for every month of transfusion was significantly higher in DBA patients in comparison with patients with TM and there was a trend towards greater and fibrosis formation.
Iron Load Can Be Severe and Presents Early in DBA Patients Even When Receiving Adequate Chelation Treatment
Josu de la Fuente1,2, Yvonne Harrington1, Sonia Bonanomi1
1Division of Paediatrics, St. Mary's Hospital, London and 2Centre for Haematology, Imperial College London,
United Kingdom
Background and Aims
Diamond Blackfan anaemia is an inherited bone marrow failure syndrome with haematological and systemic manifestations. The classical presentation of the condition is development of anaemia in infancy which occurs in approximately 85-90% of the patients. Long-term 40% require transfusions as they fail to maintain erythropoiesis at acceptable doses of steroids and as approximately only 10% of the patients go into remission . Historical data has shown that transfusion dependent patients are at risk of significant morbidity and mortality and there is evidence that despite of adequate chelation treatment, they have significantly higher iron load than other transfusion dependent anaemias.
Fifty nine patients with clinical and laboratory features consistent with Diamond Blackfan anaemia attend the specialist DBA clinic at St. Mary's Hospital (Table 1).Thirty-five patients (59.3%) had systemic features [the heart was involved in 17 patients (27.1%)], 7 patients (11.8%) had short stature only and 17 patients (28.8%) no systemic abnormalities. We have identified a ribosomal protein gene mutation in 18 patients with a novel approach [Abstract #2369] .
Twenty-nine patients are transfusion dependent, 11 steroid responsive, 7 are in remission, 9 have undergone a bone marrow transplant achieving normal haemopoiesis and 3 have never developed anaemia of sufficient severity to warrant treatment. Three have deceased (two transfusion dependent patients due to overwhelming sepsis and one following unrelated bone marrow transplantation). Twenty two transfusion dependent patients have initiated chelation treatment: 19 patients (82.5%) are currently taking deferasirox and 3 (13.6%) continuous intravenous desferrioxamine as intensification treatment. Transfusion dependent patients have had their iron load assessed by a combination of techniques: ferritin, MRI T2*, FerriScan and liver biopsy (Table 2).
Seventeen patients had severe hepatic iron load (LIC > 10 mg/g DW, maximum 38.6 mg/g DW): four before initiation of chelation treatment, 8 following chelation with desferrioxamine and 5 following deferasirox treatment. Seven of the patients had severe hepatic iron load (maximum 29.17 mg/g DW) despite of maintaining the ferritin < 1500 g/L with adequate chelation treatment following guidelines for thalassaemia (Figure 1). Severe hepatic iron load was seen as early as in the second year of life (2 years 6 months LIC 38.6 mg/g DW). In patients with severe hepatic iron load, significant reductions achieved with chelation treatment as measured by liver biopsy or FerriScan were not reflected in an increase in T2* measurement until the treatment was advanced. In addition, FerriScan showed higher LIC values than liver biopsy in keeping with its ability to provide an overall measurement not affected by fibrosis. Three patients had cardiac iron load (T2* < 20 ms) in childhood, including 2 below the age of 6 years. Seven patients required intensification of chelation with continuous intravenous desferrioxamine, which was successful in all but one despite of the use of 50 mg/kg/day.
In summary, iron overload is a significant clinical problem in patients with DBA, even when receiving adequate chelation treatment with current guidelines and at a young age. It cannot be recognised by measurement of ferritin only and it requires an algorithm that uses all available techniques in an age appropriate manner from two years of age for its detection and management.
Male cell in bone marrow adherent culture
Male cell in bone marrow before culture
CD45+ male cell
Vimentin+ male cell
Figure 2.Relationship between ferritin and LIC in patients with severe hepatic iron load
Ferritin (mg/L) in X axis and FerriScan or liver biopsy LIC (mg/g DW) in Y axis
Table 2.Assessment of iron load in transfusion dependent patients
Transfusion dependent patients monitored with ferritin, MRI T2* and FerriScan
Table 1. Patient characteristics of Imperial College Healthcare DBA Cohort.
Age of presentation, treatment and chelation of DBA patients attending specialist DBA Clinic at St. Mary's Hospital in London.
Patients with Diamond Blackfan Anaemia have abnormalities of cellular and humoral immunity
Deena ISKANDER1, Yvonne HARRINGTON2, Irene ROBERTS1,2 ,Anastasios KARADIMITRIS1, Josu DE LA FUENTE1,2.
V. Immune defects may be subclinical
Figure 2 and table 2: Lymphocyte abnormalities in patients with DBA
Fifty-nine patients with clinical and laboratory features consistent with DBA attend the specialist clinic at St. Mary's Hospital, London. Their characteristics are summarised in table 1.
Immunological parameters were available for 37 of the patients. At the time of inclusion in the study, all patients were alive and the median age was 7.8 years (range 18 months to 40.4 years).
Table 1. Characteristics of patients with DBA at Imperial College Healthcare Trust.
The male to female ratio was 1.1:1 and patients were from a broad range of ethnic backgrounds. A ribosomal protein gene mutation was known in 18/37 (48.6%) patients. Of the 37 patients, 5 were in remission, 20 transfusion-dependent, 9 steroid- responsive, 2 managed with both steroids and blood transfusions and 1 treated with allogeneic stem cell transplantation (immunological investigations were undertaken pre-transplant).
Corticosteroid therapy in DBA is delayed beyond infancy to allow administration of routine immunisations including measles, mumps and rubella (MMR) and H. Influenza type b (Hib) and minimise musculoskeletal side effects. We investigated specific antibodies against these pathogens as a marker for immunity3, as shown in figure 3. Measurements were performed at varying time points post-vaccination, but there was no correlation between age and response.
Figure 3: Immunity post-vaccination, indicated by unequivocally positive IgG against MMR and by Hib antibody titres.
A defect in lymphocytes and/or Igs was detected in 10/16 (62.5%) patients with infections. Conversely, in 9/21 (42.9%) patients, immune defects were observed in the absence of a history of infections.
Patient characteristics
Figure 1: History of infections in 37 patients with DBA.
IV. Patients with DBA have suboptimal responses to vaccination
II. B lymphocyte deficiency is the most commonly detected immune abnormality
I. Infections are common in patients with DBA
III. Reduced immunoglobulins occur in patients with DBA
Clinical information was obtained retrospectively from patients' medical records and from the Imperial College Healthcare Trust electronic data system. Lymphocyte subsets were characterised by flow cytometry and age-specific normal ranges were defined as previously described.2 Serology to identify antibodies against specific pathogens was performed using Enzyme-Linked Immunosorbent Assays.
Diamond Blackfan Anaemia (DBA) is an inherited bone marrow failure syndrome characterised by anaemia, physical anomalies and an increased risk of malignancy. Although the hallmark of DBA is anaemia due to pure red cell aplasia, some patients exhibit additional cytopaenias, suggestive of a more widespread defect in haemopoiesis. In addition, aberrant immunity has been reported1, but the scope and precise nature of these immunological defects is yet to be elucidated.
Consistent lymphopaenia was found in 7/37 (18.9%) patients, unaccounted for by concurrent medical conditions or drug therapy. Abnormalities in one or more subsets were identified in the 7 patients with low total lymphocyte counts and in a further 10 patients with normal total lymphocytes counts. A low B lymphocyte fraction was the most frequent abnormality, present in 12/37 (32.4%) patients (figure 2 and table 2).
Four of the 12 patients with reduced B lymphocytes also exhibited a defect in immunoglobulins (IgM and IgG2 deficiency in 1, IgG3 deficiency in 3). In total, low levels of at least 1 Ig isotype were detected in 4/34 (11.8%) patients. An additional 5/32 (15.6%) patients showed a selective deficiency in 1 of the 4 IgG subclasses. Importantly, these abnormalities were masked by normal total IgG levels.
Sepsis was the cause of death in 2/3 patients with DBA who died - immunological investigations had not been performed prior to death in these cases.
In 3 of the 37 patients investigated, a severe but non-fatal septic episode was reported: Salmonella gastroenteritis, Clostridium difficile colitis and neonatal pneumonia. Recurrent infections occurred in an additional 13 patients: respiratory 7/16 (54%), multisystem 3/16 (23%), otitis media 2/6 (15%) and urinary 1/37 (8%).
2 of the 16 patients with infections had longstanding neutropaenia and another 2 patients were receiving corticosteroids, but at low doses (0.15 and 0.12 mg/kg od).
Target Enrichment and High-Throughput Sequencing of 80 Ribosomal Protein Genes to Identify Mutations Associated with Diamond-Blackfan Anaemia
Gareth Gerrard1*, Mikel Valgañón1, Hui En Foong1, Dalia Kasperaviciute2, Deena Iskander1, Laurence Game3, Michael Müller2, Irene Roberts1, Timothy J Aitman2, Letizia Foroni1, Josu de la Fuente1, Anastasios Karadimitris11Centre for Haematology, Faculty of Medicine, Imperial College London, UK; 2Imperial NIHR Biomedical Research Centre, Imperial College London, UK; 3Genomics Laboratory, Clinical Sciences Centre, Imperial College London, UK. *[email protected] Work funded by AHSC/IHBRC
Diamond-Blackfan anaemia (DBA) is a rare congenital stem cell disorder associated with inactivating mutations in ribosomal protein (RP) genes, causing defects in erythroid progenitor and precursor cell development. Of the 80 or so RP genes, loss of function mutations in 10 have been definitively associated with DBA. We used high-throughput sequencing to screen all 80 RP genes in 20 DBA patient samples (3 of which were controls) and found loss-of-function mutations in 15/17 (88.2%) of the test samples.
The coordinates for all 80 RP genes were used to generate custom SureSelect hybridisation capture baits via the Agilent web portal. 3µg DNA was extracted from 20 PB samples (including 2 controls with known mutations; 6 members from 3 family groups: a mother-daughter pair, a sibling pair and another sibling pair where one sibling was non-DBA and included as a control). Covarissonication was performed and the DNA fragments were hybridised with the capture baits for 48h. After barcoded adapter ligation, the libraries were quantitated by qPCR and pooled into 2 runs of 10. The sequencing was performed on an IlluminaMiSeq using 150bp paired-end chemistry. The reads were aligned to the hg19 reference using BWA and the variant calls made using GATK; ANNOVAR was used for functional annotations of the variants. Pipelines for both SNVs/indels and large deletions/insertions were implemented, plus a separate analysis for RPS17 because of its duplicate status. Mutation validation was by Sanger sequencing on an ABI 3500.
Single nucleotide variations (SNV), small inversions/deletions (indels) and copy number variations (CNV) have been found in 10 RP genes in 25-35% of DBA patients, meaning that around 40% have no identifiable mutations (at least by conventional screening). However, given that all mutations in DBA characterised so far (with the exception of 2 cases with GATA1 mutations) affect RP genes, it is likely that mutations in one of the 80 RP genes will be eventually identified in a significant proportion of patients. Current screening methods are based on Sanger sequencing on a per-exon/per-gene basis, with the associated time, labour and cost restrictions. We therefore aimed to evaluate high-throughput sequencing technology, including a bespoke target enrichment platform, to screen all 80 known RP genes to facilitate rapid, cost-effective identification of DBA associated mutations (Figure 1).
Loss of function mutations were detected in RP genes in 17 of the 20 samples, including the 2 positive controls (Table 1). Of the 3 where no definitive mutation was seen, 1 was an unaffected sibling. All mutations were in RP genes previous described as being involved in DBA, although 7 affected novel codons. No verifiable large deletions/insertions were seen. FastQC indicated good quality sequencing metrics and all variations were subsequently validated by Sanger sequencing.
Target enrichment (Agilent SureSelect) and High-Throughput Sequencing (Illumina MiSeq) workflow for the screening of all 80 ribosomal protein genes in patients with DBA
Using custom designed target enrichment and high-throughput benchtop sequencing technology, mutations were found in 17/20 samples and of the 17 test samples, 15 were found to have mutations in RP genes associated with DBA (88.2%). Consequently, we are now optimising this approach for use as our primary screening platform.
The authors confirm that there are no relevant conflicts of interest to disclose
TABLE 1. Gene variations flagged as loss of function and validated by Sanger sequencing.
Mutations are mostly SNVs and indels, but large deletions & insertion are also seen
= 7 genes in current molecular screen
Current DBA Screening Pipeline Ribosomal Protein Genes to Identify Mutations Associated with Diamond-Blackfan Anaemia
Measure & QC
Extract DNA
Peripheral Blood
PCR target gene exons
Sanger Sequence
Target Enrichment
Hybridise and capture Ribosomal Protein Gene DNA
including exons, introns, & regulatory regions
Genomic DNA
10 patient-parent pairs
Fragment DNA
High-throughput Sequencing
Library quant, pool, clean up and cluster generation
Data analysis
Sanger seq validation
SG= Stop Gain SNV (Nonsense); FSD= Frame-shift Deletion; FSI= Frame-shift Insertion;
SL= Start Loss SNV (Missense); SSD= Splice Site Defect
Optimise NGS for upfront DBA screening
Agilent Haloplex
Ion Torrent High Throughput Seq
+ MLPA Assay for validation of large deletions
St Marys Hospital London has the largest cohort of DBA patients worldwide
72 DBA patients currently registered at St Mary's Hospital
31 patients have had a bone marrow aspirate
29 samples suitable for analysis (n=29)
10 normal paediatric controls
Reduced erythrocyte % in DBA patients
The Erythroid Lineage Ribosomal Protein Genes to Identify Mutations Associated with Diamond-Blackfan Anaemia
Non lobulated
Normal lobulation


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Deo Gratias is Latin for "Thanks be to God." Remembering to give thanks for all of our blessings, big and small, helps us to find God in our everyday moments and gives us an attitude of gratitude! I invite you to share your blessings here on Wednesdays. Be sure to sign into Mr. Linky below and grab the button.
1. Thank you, Lord, for my hubby, who loves me and encourages me and helps me to keep going through the good and the bad. Deo gratias!
2. Thank you, Lord, for the restful, peaceful weekend we had last weekend. Just what we needed. Deo gratias!
3. Thank you, Lord, for giving me patience when I needed it so badly. I mean, really needed it. Deo gratias!
4. Thank you, Lord, for the sunset I watched this evening. So beautiful. Pink and orange wispy clouds. Such a painting you gave me, Lord. Deo gratias!
5. Thank you, Lord, for music. Music is beauty and joy. Music is uplifting. Music speaks to our hearts. St Augustine said that those who sing "pray twice." Amen! Deo gratias!
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Tag Archives: fact check
Myth #4: "We will be $1.6 billion in debt by 2024."
Myth #3: "Cancelling LRT will lower your taxes."
Myth #2: "LRT will cost more to operate than buses"
Myth #1: "We can save money by cancelling LRT"
Mythbusting the election: A week-long series
Monday: Myth #1 "We can save money by cancelling LRT"
Tuesday: Myth #2 "LRT will be more expensive to operate than buses"
Wednesday: Myth #3: "Cancelling LRT will lower your taxes."
Thursday: Myth #4: "We will be $1.6 billion in debt by 2024."
Friday: Myth #5: "LRT won't benefit me."
It's election time in Waterloo Region, and it's getting a bit crazy out there. While many candidates are presenting strong ideas and platforms, a few opportunists have carved out a "cancel LRT" niche, and they're not afraid to kick the facts to the curbside to sell it. TriTAG is calling them out.
If you've been following us for a while, you'll know that TriTAG has supported ION as a good plan to bring rapid transit to Waterloo Region. But we have also challenged the project team to make ION even better, sometimes being sharply critical of some decisions they have made. TriTAG wants to see ION be the best it can be: light rail will bring a lot of change to our cities, and will bring real transportation choice to many thousands of people. We have to get it right.
But change naturally has some voters concerned, and a few politicians are trying to cash in with single-issue campaigns designed to play up to people's fears. That's where we come in. TriTAG is going to put the myths being spread during this election to the test, to help you make your vote an informed one.
We hope you'll join us.
Want to learn more?
- TriTAG Election Candidate Survey: Find out where candidates stand on ION and transit!
- ION's route, animated: Think it's just a mall to mall train? Think again.
- ION Infographic: Find out the facts about ION, and how it will benefit you.
Free transit: a solution for Waterloo Region?
Find our election survey for Waterloo Region, Cambridge, Kitchener, and Waterloo candidates at tritag.ca/election2014
A new candidate , John Wolf, has officially entered the race for Regional Chair. Wolf claims that as Chair, he would try to cancel light rail, and as an alternative, investigate making transit free in an effort to boost ridership.
Last month, TriTAG investigated the claims of (as of yet unregistered) Regional Chair candidate Jay Aissa concerning the light rail project. Today, we will explore the issue of free transit and try to address two questions that arise from Wolf's platform: is free transit a viable alternative to light rail and rapid transit, and what would the impact of free public transit be on Waterloo Region?
Fact-checking municipal campaigns: Jay Aissa
Check out our Mythbusting the Election series for more fact-checking and mythbusting of candidates like Jay Aissa.
Find our election survey for Waterloo Region, Cambridge, Kitchener, and Waterloo candidates at tritag.ca/election2014
In 2011, when light rail was being debated and ultimately decided upon, there was a great deal of misinformation being spread about light rail and its suitability to Waterloo Region. During that time, TriTAG debunked many of these myths so that an informed public debate could occur.
As the 2014 municipal election period builds momentum, false information about light rail is once again emerging. As democracy depends on an informed electorate, we've decided to fact-check egregious statements candidates make regarding light rail and other issues for which we advocate. We begin with Jay Aissa, who in his interview shortly after declaring his intent to run for Regional Chair, made several false claims concerning the light rail project.


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Sep 112014
Joseph Ferguson is an author, poet, and journalist appearing in a variety of small press, regional and national publications. He wrote propaganda for a living for a variety of entities for some 25 years.
He is a former editor and critic for Hudson Valley, ran the Fiction Workshop for the Poughkeepsie Library District, and regularly reviews books and videos for Climbing, The American Book Review, Kirkus Indie, and a number of other publications.


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New trends fashion design with :
Gold Jewelry Design Catalog and Indian Jewellery Design Gold Necklace Collection Gold Necklace
Many people like Gold Jewelry Design Catalog, for fashion collection and news style in this year. If you have enjoyed this Gold Jewelry Design Catalog here, please just do me a favour by sharing it using any of the social media icons present below. I will really appreciate it when you do just that. Cheer! Regards from Sorayakusumawati Fashion collection site.


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And here are some pictures of them
The Women We Love This Week
And here are some pictures of themMore
Abi went to the award show proper, which was at the O2.
The Gandy, meanwhile, showed up later at at the Universal Music after party, hosted by Soho House and Barcardi. Esquire was also there, though there is thankfully no pictorial evidence.
Women We Love This Week


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Kilaka Hand Gesture (Mudra)
When both the little fingers interlock each other we get the Kilaka Hasta.
Lets take a look at the Viniyoga shloka (uses)
snehe namranulape cha kilako viniyujyate
The shloka says that this kilaka hasta is used to denote
- A feeling of Love and affection
- Funny talks, hilarious conversation etc
Tags: Bharatanatyam · Double · Gestures · Hand · Hastas · Indian classical dance · Mudras · Samayutka · shloka · uses · viniyoga


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Latest Stories
Skate Review0 Comments
September 11, 2007
Skate Preview0 Comments
August 1, 2007
Help us solve the toughest (or most puzzling) game puzzles and challenges.
Our attempt to answer issues which most commonly occur on IGN's wikis.
About This Game
- Summary
- Specifications
- Game Editions
Skate puts extreme skateboarding action on your phone. Skate through San Vanelona, and pull off trick combos. Stick kick-flips, ollies, 360s and more – catch big air and keep the photojournalists busy. Outfit your skater with different clothes, and interact with some of today's hottest skaters. Enjoy freestyle and location-based game modes. Whether you're crooked-grinding 20-stair hand rails, or a newbie trying to earn respect - Grip it & rip it with Skate!
- Supported Functions
- Number Of Players: 1
SkatePublisher: EA MobileRelease Date: September 13, 2007


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£1350 Per Month
** Landlord Is Open To Offers**
Eagle Heights SW11 2LJ
Absolute Living are delighted to offer the lettings market this large one double bedroom flat in a secure gated development opposite Clapham Junction station in the popular Falcons Developement SW11.
Available Now
The flat is situated in the 12th floor on Eagle Heights and comprises of a good size double bedroom with lots of storage space, a spacious bright and airy reception room and a modern tiled bathroom.
Situated on the doorstep of Clapham Junction it is a secure compound with allocated parking space included in the rent as well as free leisure facilities like swimming pool, jacuzzi, sauna and gym. and there is also a landscaped communal garden.
It is perfect for a single professional or professional couple looking in the area with Clapham Junction BR station right opposite and a great range of shops, bars, cafes and restaurants surrounding Clapham Junction.
Super flat sure to go very quickly to avoid disappointment
Call Shakil On 07507793246 To Arrange A Viewing.
•Eagle Heights SW11
•One Bedroom Flat
•Lots Of Storage Space
•Opposite Clapham Junction Station
•FREE Swimming Pool, Jacuzzi, Sauna & Gym On Site Included In Rent
•Allocated Parking Space Included In Rent
•Cheap Council Tax – Wandsworth
•Available Now
•Stunning Views
•Secure Development
•Available Furnished
Call Shakil On 07507793246 To Arrange A Viewing.


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Love Me If You Dare Trailer (2003)
17 September 2003 Drama, Comedy, Romance 93 mins
As adults, best friends Julien and Sophie continue the odd game they started as children -- a fearless competition to outdo one another with daring and outrageous stunts. While they often act out to relieve one another's pain, their game might be a way to avoid the fact that they are truly meant for one another.
Watch the official Love Me If You Dare 2003 trailer in HD below or find more Love Me If You Dare videos on Vidimovie.


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A UK perspective on the EC Anti-Tax Avoidance Package unveiled on 28 January.
In last week's Weekly Tax Matters we discussed the new Anti-Tax Avoidance Package unveiled by the European Commission (EC) on 28 January 2016. This includes two legislative proposals: a directive addressing certain anti-base erosion and profit shifting (BEPS) issues and an amendment to the Directive on Administrative Cooperation to include non-public country-by-country reporting (CBCR). It also contains a Communication on an External Strategy for Effective Taxation, which proposes a common approach to tax good governance towards third countries, and a Recommendation on Tax Treaties. Further commentary has now been prepared to provide a UK perspective of the proposals, in particular for those groups which are either UK parented, or with a significant UK sub-group and UK operations.
This UK focused commentary can be found here. KPMG's EU Tax Centre Tax Flash (ETF 273) provides further details of all the proposals at a pan European level. As noted in ETF 273, the proposals put forward by the EC require unanimous approval from all 28 Member States before becoming law. Whilst it is acknowledged that the EC is pressing for the quick adoption of the proposals, it is unclear at this stage how feasible this is at both a political and practical level. Regardless of this, the proposals do provide a valuable insight into the 'direction of travel' and wider intentions of the EC.
Please speak to your usual contact if you'd like to discuss any implications for your group.


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Gooood morning!
I feel like I'm well rested but also like I can sleep for about six more hours right now. I'd blame it on having a busy Wednesday but I am not going to complain about my perfect day of running, working and then going out for dinner. So let's just conclude that I am tired for absolutely no reason.
Wednesday morning started with a run (for me) and a ride (for the BF). I had a late start at work which was so nice and gave me a little extra time in the morning. The weather was supposed to be really nice all day so I suggested we get our workouts out of the way early so that we could enjoy a night out. I used to run/work out super early all the time and forgot how good it feels to have it all done before starting my work day!
Had some waffles post-run, did the work thing, went home and vacuumed (exciting), ran around like a lunatic looking for my wallet (it was in my car), and got ready for dinner. Nothing like a Garmin watch to complete your outfit! 😉
We went to Cafe Nervosa in Yorkville and it was DELICIOUS. Got to sit on a patio and everything. To start, we got the Insalata di Cavolo Nero – lacinato kale, zante currants, toasted pine nuts, shaved pecorino, parmigiano, lemon vinaigrette.
For my main, I got the Gnocchi di Ricotta – homemade buffalo ricotta gnocchi, ramp pesto, Marcona almonds, pecorino…and he got the Mafalde ai Funghi – portobello, porcini, crimini, oyster mushrooms, parmigiano, truffle paste, light cream sauce.
I died and went to heaven. I love pasta. I also love fitting into my pants so I think tonight I will eat a salad. Hah.
Anyway, I just wanted to talk real quick about sharing run times and paces. Maybe get some opinions. For a long time, I only really shared my paces when I felt like they were "good". I'd do my weekly run recaps or my Marathon Mondays and share numbers when they were fast (for me), but conveniently leave them out when my paces were slow or less impressive. WHY?! Looking back, I'm kind of disappointed that I felt embarrassed and considered myself to be "less than" or inferior to those who could run faster than me. There are times (like right now) when my training is going to be easy and my goals are going to be to build a base rather than get fast. And that is okay! I want to be transparent and share both the good days and the bad days, the easy days and the hard days, the slow days and the fast days. It all counts and every single run plays a role in getting us to our end goal.
I also know people who don't post their times, paces or race results anywhere. Even some super fast friends refrain from doing that for whatever reasons they may have and that's okay too! I just want to be able to share as much of my journey as I can and am totally okay with plastering my times on the Internet. I personally enjoy following other people and reading about their workouts – I find it inspiring and it really motivates me to work hard. If reading about my training can do that even for just one person, I'm all smiles.
Hope you are all having an amazing week so far. Get out and enjoy that sunshine!


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I recently did my World Rugby Level 1 officiating but cant seem to find my certificate under my profile. Can you please assist me
Thank you
Nico Henery
Good Day
I recently did my World Rugby first-aid level 1 but cant seem to find my certificate under my profile. Please assist.
Shaakira Koraan
Hi Nazmus, thank you for my email. This is now sorted.
Hi Shaakira - unfortunatley i cannot locate this course on your record. This means that the Educator has not added it to our online system. Please can you confirm who the Educator is and I will investigate. Thanks, Jennifer
I am completing my level 2 coaching course but can not find the pre requisite certifications. Would you kindly point me in the direction of how to find them.
Rugby Ready
Scrum Factory
Head Case
Laws of the Game
Hi Douglas, when you log into passport and go to the World Rugby Laws of the Game or Rugby Ready site you should see an icon of a certificate once you have completed them. You will be able to download a copy when you click on the certificate.
I'm afraid the Scrum Factory and Head Case exams are specific to the RFU so you cannot download these from World Rugby Passport.
I am not able to find my level coaching certificate that i did in 2014? Please advise
Hi Sheikh, please give me your email address and I will send a copy to you.
To Jennifer
Good day to you, hope you well.
My name is Johan and i did my level 1 a couple weeks ago and i am still waiting for my certificate. Rugby seasson is starting soon and i need it.
Any help will be appreciated.
email is email@example.com
Edited by Johan Pelser on 6th Mar 2017 at 08:23
Thanks Sheikh. I'm sending you a copy now.
Hi Johan, I cannot find a course on your record just now so please can you confirm the date, location and type of course you took part in so that I can look into this for you. It may be that the Educator has not uploaded it yet.
Thank you.
Thank you Jennifer.
I will confirm the dates and venue asap.
Hi I finished my IRB coaching level I (20113 and Level II (2014) but can't seem to find it on my profile site.
I still have a printout of my level I accr.
Can you help me locate these certificates?
educator: Eric Voet (Netherlands)
I have done Rugby Ready course but I can't access my certificate. Can you help?
I did my irb level 1 officiating in 2008, and lost my certificate .
How wil I be able to recieve a new one.
Monre Gilbert


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We need you to
Prepare 2 audition monologues (see below) – each lasting no longer than 2 minutes:
- One from a contemporary play (after 1990)
- One Shakespearean/Jacobean (but not non-human characters like 'Puck' from A Midsummer Night's Dream or 'Ariel' from The Tempest, or any 'Chorus')
Please make sure you have read the whole play your monologue comes from. Be sure your monologue works as a stand-alone speech and does not require input from another character. Your speech must be taken from an existing play, and not a book of solo speeches. (Speeches found in monologue anthologies are acceptable provided you have read the whole play from which they are taken.)
We want you to:
- Choose pieces that match your age & gender.
- Work without props or special costume.
- Avoid using chairs.
- Learn your pieces.
- Avoid using the panel for eye line.
- Use your natural accent.
- Wear suitable clothes which enable you to move freely and to allow tutors to assess posture and movement. Female applicants should avoid skirts. All applicants should avoid low cut/hipster trousers cropped and low cut tops. For both the warm up sessions we advise you to bring movement clothes (leotard and tights). The movement session requires you to be bare footed and to work without any jewellery.
We are looking for these qualities:
- Truth
- Preparation
- Ability to create and sustain a character within an imagined world
- Evidence of thought and feeling behind the actions and words
- Ability to take direction (to hear an instruction and adapt own performance accordingly)
- Ability to communicate text
- Ability to express thought and feeling through movement and voice
- Self-confidence, focus and concentration
- Spontaneity and immediacy
- Openness and responsiveness to others Imagination and creativity
- Evidence of stamina and co-ordination
- An interest in the craft of acting and in the professional world of acting
We aim to ensure that you will enjoy all aspects of the auditioning process and feel stretched by it.
You will have every opportunity to show your skills.
ALRA follows the 'Auditioning and interviewing for Dance & Drama Code of Practice' as detailed on the CDET and EFA websites.