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Larson, Eric. The 11 Million-Year-Old Whale Fossils You could potentially 3D-Print in your home. March 09, 2014.(accessed Might 06, 2014).
Vissar, Jasper. Museums in occasions of social and technological improve. April 18, 2014. (accessed May possibly 06, 2014).
(Larson 2014)
(Vissar 2014)


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Charles Author Hunnefield
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- Date of birth: May 9, 1924
- Date of passing: Feb 27, 2001
|Let the memory of Charles be with us forever
This memorial website was created in memory of our loved one, Charles Hunnefield, 76, born on May 9, 1924 and passed away on February 27, 2001. We will remember him forever.
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Custom property builders design structures especially for each operator or in accordance with their pair of unique plans. One of the most vital areas of house design could be the roof. There are lots of styles to pick from, from any involved gambrel into a simplistic pyramid. Here's a review of some favorite styles to debate with the custom property builders.
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Автор: Jordan R.R.
Раздел: Cambridge University Press
|Под заказ. Поступление на склад 17.12.2017
This book provides a comprehensive overview of the field of English for Academic Purposes (EAP) for teachers. It not only looks at study skills, but also at other central concerns of EAP, such as needs analysis, syllabus and course design, methodology and materials, learning styles, tests and exams, and academic style and genre analysis. In addition to general EAP, the author also considers subject-specific language and the production of teaching materials. Throughout, the author adopts a user-friendly approach in which theoretical considerations are balanced with practical experience. Issues are discussed and illustrated, but readers are also encouraged to form their own opinions by means of stimulating introspect and discuss sections at the end of each chapter.
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Written mostly in the form of diaries and journals, the classic story of the powerful, centuries-old vampire tracks the cruel count from Transylvania to England, where he devastates London until Doctor Van Helsing ends his bloody reign.
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Liver X Receptor α is a nuclear transcription factor that regulates lipid metabolism. Recently, it has been shown that activation of LXRα with synthetic ligands has anti-inflammatory effects in atherosclerosis and chemical-induced dermatitis. Here, we investigated the effect of the LXRα agonist T0901317 on lung inflammation in a rodent model of hemorrhagic shock. Hemorrhagic shock was induced in male rats by withdrawing blood to a goal mean arterial blood pressure of 50 mmHg. Blood pressure was maintained at this level for 3 hours, at which point rats were rapidly resuscitated with shed blood. Animals were then treated with T0901317 (50 mg/kg) or vehicle intraperitoneally and sacrificed at 1, 2 and 3 hours after resuscitation. Treatment with T0901317 significantly improved the cardiac and stroke volume indices as well as heart rate of rats during the resuscitation period as compared to vehicle-treated rats. T0901317-treated animals showed significant improvement in the plasma level of lactate, while base deficit and bicarbonate levels both trended towards improvement. T0901317-treated animals also showed lower levels of the plasma cytokines and chemokines MCP-1, MIP-1α, TNF-α, KC and IL-6. Lung injury and neutrophil infiltration were reduced by treatment with T0901317 as evaluated by histology and myeloperoxidase assay. At molecular analysis, treatment with T0901317 increased nuclear LXRα expression and DNA binding while also inhibiting activation of NF-κB, a pro-inflammatory transcription factor, in the lung. Thus, our data suggest that LXRα is an important modulator of the inflammatory response and lung injury after severe hemorrhagic shock, likely through the inhibition of the NF-κB pathway.
Traumatic injury and subsequent hemorrhage continue to be a major worldwide health concern. Hemorrhage is the second-leading cause of mortality amongst all trauma victims, leading to 30–40% of all deaths in injured patients (1). While many deaths occur in the pre-hospital phase, some patients reach the hospital and enter the resuscitative phase of care. As a result of injury and hemorrhage, these patients show a massive inflammatory response. This inflammatory response results in the release of many cytokines and chemokines as well as activation of the innate immune system. The initiation of this cascade can quickly change from adaptive to maladaptive and lead to further injury including multi-organ failure (MOF) and death (2–4). Given the severity of the response and its consequences, down-regulation of this inflammatory cascade has been a focus of research in attempts to avoid the MOF and death often encountered after hemorrhage and resuscitation.
The Liver X Receptor (LXR) is a ligand-dependent nuclear transcription factor that is a regulator at the intersection between metabolism and inflammation (5–9). There are two sub-types of LXR, α and β. While LXRβ is expressed ubiquitously, LXRα expression is confined to select organs including the spleen, liver, intestine, adipose and lung. LXRα can be activated by natural ligands, mainly oxysterols, or synthetic ligands such as T0901317 or GW3965. Once activated, the nuclear receptor forms a heterodimer with Retinoid X Receptor (RXR). This heterodimer then binds to the LXR response element (LXRE) on DNA, leading to transcription of various genes important in cholesterol metabolism. (5–9).
Several in vitro studies have shown that LXR agonism not only regulates cholesterol metabolism, but also exerts anti-inflammatory effects. It has been shown that activation of LXRα decreases pro-inflammatory cytokine levels following endotoxin exposure. These cytokines include tumor necrosis factor α (TNFα), inducible nitric oxide synthase (iNOS), interleukin-6 (IL-6), cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), macrophage inflammatory protein1α (MIP-1α), matrix metalloproteinase-9 (MMP-9) and monocyte chemoattractant protein 1(MCP-1)(10–13). In addition to these in vitro anti-inflammatory effects, LXRα agonism has also been shown to decrease inflammation in vivo. In models of contact dermatitis, tissue inflammation was markedly reduced with LXRα activation (11, 14). Further studies have also shown in vivo reduction of lung neutrophil infiltration after exposure to irritants and LPS (15, 16).
The exact mechanism through which LXRα activation reduces inflammation remains unclear, but many studies point to a regulation of the Nuclear Factor-κB (NF-κB) pathway as a possible mechanism. NF-κB is a pro-inflammatory transcription factor that initiates transcription of a multitude of pro-inflammatory mediators, including cytokines, chemokines and adhesion molecules (17). It has long been acknowledged that NF-κB is a key regulator in the inflammatory response and would be an ideal target for therapeutic intervention aimed at preventing the overwhelming inflammation seen after insults such as hemorrhagic shock (18). We have previously shown that some of the anti-inflammatory properties of LXRα activation may be secondary to reduction of NF-κB activity. Our in vitro study showed that LXR agonism prevented the production of pro-inflammatory cytokines by reducing IκB alpha degradation and subsequent NF-κB activation in macrophages (19).
These promising results suggest that LXRα activation could be a key component in reduction and control of the overwhelming inflammatory response following hemorrhagic shock. Our aim in this study was to explore the anti-inflammatory effects of the LXRα agonist T0901317 in a rodent model of hemorrhagic shock. We hypothesized that activation of LXRα by T0901317 would stem the systemic inflammatory response via inhibition of the NF-κB pathway and subsequently reduce hemodynamic abnormalities and hemorrhage-induced lung injury.
All aspects of this study complied with the Guide for the Care and Use of Laboratory Animals published by the US National Institutes of Health (NIH Publication No. 85–23 revised 1996) and met approval of the Institutional Animal Care and Use Committee. Male Wistar rats (Charles River Laboratories, Wilmington MA) weighing between 240–310 grams were subjected to hemorrhagic shock. Each animal was anesthesized using intraperitoneal pentobarbital (80 mg/kg). Tracheostomy was then performed and the animal was ventilated at a respiratory rate of 60 breaths per minute, tidal volume of 7 mL/kg and FiO2 of 0.4 using a rodent ventilator (Harvard Apparatus, Holliston MA). Temperature was maintained at 37° C using a homeothermic blanket. The left carotid artery and right femoral artery were then cannulated with Polyethylene-50 tubing. For cardiac output measurement, polyethylene-10 tubing was inserted into the right internal jugular vein as well. Cardiac output (mL/min) was measured using a thermodilution technique (20). A thermistor was passed into the left carotid artery to the carotid arch. 0.15 mL of normal saline at room temperature was then rapidly injected into the right internal jugular vein. Heart rate (HR), mean arterial blood pressure (MABP) and cardiac output were measured using a Maclab A/D Converter and cardiac output pod (AD Instruments, Milford MA). The cardiac index (CI, mL/min/100g), total peripheral resistance index (TPRI, mmHg/mL/min/100g) and stroke volume index (SVI, mL/100g) were then calculated from computed integral values of thermodilution curves using standard arithmetic formulae.
After completion of the surgical procedure, rats were dosed with intravenous heparin to facilitate hemorrhage (100 IU/kg). Hemorrhagic shock was then induced using a pressure-controlled model as previously described (21). Blood was steadily withdrawn from the femoral arterial catheter until a MABP of 50 mmHg was obtained. This MABP was then maintained for a period of three hours by withdrawing or re-instilling small volumes of shed blood. After three hours of shock state, shed blood was rapidly re-infused over 5 minutes to resuscitate the animal. If re-transfusion of small volumes of blood were needed during the hypoperfusion period to maintain MABP at 50 mmHg, rapid resuscitation at the conclusion of hemorrhage was performed by transfusing the remaining shed blood supplemented with Ringer Lactate solution to a final volume of fluids equal to the initial total shed blood.
Animals were then randomly divided into three groups: 1) Rats in the vehicle hemorrhagic shock group received vehicle (100% dimethyl sulfoxide) instead of T0901317 (N=18). 2) Rats in the treatment group received T0901317 at a 50 mg/kg dose (N=16). 3) Sham operated animals served as control at time=0 and underwent the same surgical procedure but were not bled (N=4). T0901317 and vehicle were delivered intraperitoneally (i.p.) as a bolus at the beginning of resuscitation (180 minutes) and every hour thereafter for a maximum of three doses. Rats were sacrificed at 1, 2 and 3 hours post-resuscitation. Plasma and lung samples were collected for histologic and biochemical studies.
Plasma levels of lactate, base deficit and bicarbonate were measured at times 0, 3 and 6 hours using a commercially available i-Stat system (Abbott Point of Care, Princeton, NJ).
Plasma levels of MIP-1α, TNFα, IL-6, interleukin −10 (IL-10), KC, and MCP-1 were analyzed using a luminex multiplex system (Luminex Corporation, Austin TX) according to instructions from the manufacturer.
Plasma levels of total cholesterol were measured by enzymatic procedures using a commercially available kit (Wako Diagnostics, Richmond VA).
Lung tissue was harvested and placed immediately in 10% neutral buffered formalin. The tissue was then embedded in formalin, sectioned and stained with hematoxylin and eosin. Light microscopy was used to evaluate cross-sections for tissue damage and inflammation.
Myeloperoxidase was measured as an indication of neutrophil infiltration in lung tissue following hemorrhagic shock. Lung tissue was homogenized in a buffer containing 0.5% HTAB in 10 mM MOPS. After homogenization, tissue was centrifuged for 30 min at 4,000 rpm at 4° C and supernatant was collected. Supernatant was then mixed with 3,3,5,5 tetramethylbenzidine and sodium phosphate buffer pH 5.5 in a 1:20 dilution. After 5 minutes of incubation, 0.1 mM H2O2 was added and the reaction was halted 3 minutes later by addition of 2 M acetic acid. Spectrophotometry was used to assess for rate of change of absorbance at 650nm. Myeloperoxidase activity was defined as the quantity of enzyme degrading 1 µmol hydrogen peroxide/min at 37°C and was expressed in units per 100 mg of tissue.
Lung tissue was homogenized using a polytron homogenizer (Brinkman Instruments, West Orange NY) in a buffer containing 0.32 M Sucrose, 10 mM Tris HCl, 1 mM EGTA, 2 mM EDTA, 5 mM NaN3, 50 mM NaF, 10 mM Mercaptoethanol, 20 µM Leupeptin, 0.15 µm Pepstatin A, 0.2 mM PMSF, 1 mM sodium orthovanadate and 0.4 nM microcystitin. Samples were then centrifuged at 1,000g for 10 min at 4°C. The supernatant was collected as cytosol extract. The pellet was washed in buffer and centrifuged at 3500 rpm for 10 min at 4°C. The supernatant was removed and the remaining pellet was washed in a buffer containing 50 mM Tris-HCl pH 7.5, 250 mM NaCl, 3 mM EDTA, 3 mM EGTA, 1% Triton X-100, 0.5% NP40, 10% Glycerol, dH2O, 0.2 mM PMSF, 0.1 mM sodium orthovanadate and aprotinin. This solution was then centrifuged at 15,000 g for 30 min at 4°C. The supernatant was then collected as nuclear extract.
The nuclear content of LXRα was measured using immunoblot analysis on nitrocellulose membranes using primary antibodies against LXRα and secondary peroxidase-conjugated antibody. Membranes were also probed with primary antibody for β-Actin to ensure equal loading of samples. Immunoreaction was visualized via chemiluminescence on a photographic film. Densitometric analysis was performed using ImageQuant software (Molecular Dynamics, Sunnyvale CA.).
Oligonucleotide probes corresponding to the NF-κB consensus sequence (5'-AGT TGA GGG GAC TTT CCC AGG C-3') or LXRα sequence (5'-GGC AAG AAG TAA CTG TCG GTC AAA TCC T-3') were labeled with γ-[32-P]ATP using T4 polynucleotide kinase and purified in Bio-Spin chromatography columns (BioRad, Hercules CA). A standard amount of nuclear extract protein was incubated in EMSA buffer (12 mM HEPES (pH 7.9), 4 mM Tris-HCl (pH 7.9), 25 mM KCl, 5 mM MgCl2, 1 mM EDTA, 1 mM DTT, 50 ng/ml poly(d(I-C)), 12% glycerol (v/v), and 0.2 mM PMSF) for 10 minutes. The radio-labeled probe was then added and incubated on ice for another 30 minutes. Samples were loaded into a polyacrylamide gel consisting of 5% acrylamide (29:1 ratio of acrylamide:bisacrylamide) and protein/nucleic acid complexes were resolved using electrophoresis at a constant current of 30 mA for 60 minutes in a buffer of 0.5X TBE (45 mM Tris-HCl, 45 mM Boric Acid, 1 mM EDTA). Gels were then transferred to Whatman 3M paper and dried under a vacuum at 80° C for one hour and exposed to photographic film at −70° C with an intensifying screen. Densitometric analysis was performed using ImageQuant software (molecular dynamics, Sunnyvale CA) (22, 23).
Primary antibodies directed against LXRα were obtained from Santa Cruz Biotechnology (Santa Cruz, CA). The primary anti-body directed against β-Actin was obtained from Abcam (Cambridge MA). The LXRα agonist T0901317 was obtained from Cayman Chemical Company (Ann Arbor MI). The oligonucleotide probes for NF-κB were obtained from Santa Cruz Biotechnology (Santa Cruz, CA). The oligonucleotide probe for LXRα corresponded to a previously published LXR consensus sequence (24) and was synthesized by Invitrogen Corporation (Carlsbad, CA).
Statistical analysis was performed using SigmaStat for Windows Version 3.10 (SysStat Software, San Jose CA). Data are represented as mean ± SEM of n observations, where n represents the number of animals in each group. Hemodynamic parameters were assessed using a general linear model for repeated measures allowing for missing data. For the remainder of the data, a two-way analysis of variance with Bonferroni or Holm-Sidak correction was used.
Rats selected for treatment with vehicle or T0901317 had similar heart rate (HR) (427 ± 9 bpm and 421.9 ± 10 bpm, respectively) and mean arterial blood pressure (MABP) (120.69 ± 3.3 mmHg and 117.7 ± 5 mmHg respectively) at baseline and had similar maximum volumes of blood and percentage of total blood volume withdrawn during the hemorrhagic shock phase (Fig 1, Table 1). The volume of Ringer Lactate solution delivered during resuscitation was also similar between the two groups (Table 1). Following resuscitation, MABP was similar in both vehicle and T0901317-treated groups (Fig. 1A). However, treatment with T0901317 significantly blunted hemorrhage-induced tachycardia at all measured time points when compared to vehicle treated animals (P < 0.001) (Fig. 1B). In addition, cardiac index (CI) and stroke volume index (SVI) were all increased in the T0901317-treated animals as compared to the vehicle group. While only certain time points showed significantly higher CI or SVI in T0901317-treated rats versus vehicle-treated rats, both CI and SVI were significantly higher in T0901317-treated rats as compared to vehicle-treated rats during the cumulative resuscitative period (P < 0.005 and P < 0.001, respectively) (Fig. 2).
T0901317-treated animals showed fewer signs of metabolic acidosis compared to vehicle-treated animals at 180 minutes post-resuscitation. Although not statistically significant, plasma bicarbonate levels were higher (22.23 ±1.66 µg/mL vs 18.9 ± 2.42 µg/mL) and base deficit was less negative (−3.5 ± 1.67 versus −7 ± 3.62); while plasma lactate levels were significantly lower (2.5 ± 0.4 µmol/mL vs. 4.4 ± 0.94µmol/mL, P < 0.05) in T0901317-treated animals compared to vehicle-treated animals (Fig. 3).
At histological examination, hemorrhagic shock resulted in severe lung injury characterized by reduced alveolar space and accumulation of inflammatory cells in vehicle-treated rats. On the contrary, histological images of rats treated with T0901317 (Fig. 4C) showed preservation of lung architecture and a reduction of neutrophil infiltration when compared to vehicle treated rats at 180 minutes post-resuscitation (Fig. 4B). The degree of neutrophil infiltration in the lungs was further confirmed by measurement of myeloperoxidase activity. At 180 minutes post-resuscitation, there was significantly less myeloperoxidase activity in the lungs of rats treated with T0901317 as compared to vehicle-treated rats (613±34 U/100mg tissue versus 728±35 U/100mg tissue, respectively; P < 0.05) (Fig. 4D).
Plasma levels of cytokines and chemokines were measured at 60 and 180 minutes post-resuscitation. There was a significant decrease in plasma concentrations of MCP-1, MIP-1α, TNFα and KC in T0901317-treated animals when compared to vehicle-treated rats. Although lower than vehicle-treated rats, plasma levels of IL-6 were not significantly different in T0901317-treated rats. Levels of IL-10 were similar in both groups (Fig. 5).
Since LXRα is a crucial regulator of cholesterol metabolism, we also measured plasma levels of cholesterol. There was a significant increase of plasma total cholesterol concentration in vehicle-treated rats (74.1 ± 6 mg/dL) at 180 minutes post-resuscitation when compared to basal levels of sham control rats (55.2 ±4.8 mg/dL). Treatment with T0901317 did not significantly change plasma concentration of total cholesterol (77.8 ± 5.1 mg/dL) at 180 minutes post-resuscitation when compared to treatment with vehicle alone (P = 0.65
To confirm the mechanism of action of T0901317 on the LXRα pathway, we evaluated both the expression of the receptor as well as its DNA binding at 180 minutes post-resuscitation in lung nuclear extracts. At basal condition, a faint constitutive band was observed in sham animals. After resuscitation, there was an increase in the nuclear expression and DNA binding of LXRα in both vehicle-treated and T0901317-treated rats. However, treatment with T0901317 significantly increased both the nuclear expression and activity of the receptor when compared to vehicle-treated rats (P < 0.05) (Fig. 6).
To explore the role of LXRα activation in the NF-κB pathway, we investigated the amount of NF-κB bound to the DNA in rat lung nuclear extracts after hemorrhage and resuscitation. Sham animals showed a faint constitutive band at basal condition. Hemorrhage and resuscitation increased DNA-binding in both vehicle and T0901317-treated animals. However, at 60 minutes post-resuscitation, we found that T0901317-treated rats had significantly decreased binding of NF-κB in lung nuclear extracts as compared to vehicle-treated rats at the same time point (Fig. 7).
Our study has shown that activation of LXRα with the synthetic ligand T0901317 improves the hemodynamic profile of rats subjected to severe hemorrhage and resuscitation. Furthermore, lung injury and neutrophil infiltration are reduced with LXRα activation. This pulmonary protection is seen in conjunction with a decrease in plasma cytokine and chemokines levels. These anti-inflammatory effects are likely due to an inhibition of the NF-κB pathway. These findings all suggest that LXRα regulates inflammation after a hemorrhagic insult on a systemic scale, though its effects on organs other than the lungs remains to be explored.
In our study, we used a pressure-controlled model of hemorrhagic shock to standardize the level of hypoperfusion during the hemorrhage phase. After resuscitation, LXRα activation significantly decreased heart rate while also increasing stroke volume and cardiac index. Interestingly, there was no significant change in the MABP post-resuscitation despite these positive findings. One possible explanation for this is the interaction between LXRα and the Renin-Angiotensin System (RAS). Several studies have shown that activated LXRα interacts with the RAS, leading to decreased renin levels and a decreased response to Angiotensin II (25–27). This interaction would limit the ability of animals to vasoconstrict and increase their blood pressure. Concordant with this hypothesis, we did not observe any changes in total peripheral resistance (data not shown) in rats treated with T0901317, despite improvements in other hemodynamic parameters.
Improvement of hemodynamic parameters such as CI and SVI implies that systemic oxygen demand has decreased. However, systemic markers of acidosis are used in conjunction with hemodynamic parameters to clinically assess cellular hypoxia (28). Among the values used are plasma lactate, base deficit and bicarbonate. In our study, we found that activation of LXRα significantly improved plasma lactate and showed a trend towards improvement of bicarbonate and base deficit as compared to vehicle-treated animals. This indicates that therapy with T0901317 improved end organ perfusion and abrogated cellular hypoxia, leading to less metabolic acidosis. However, the role of LXRα activation in glucose utilization cannot be ignored. Several studies have shown that activation of LXRα leads to increased pancreatic insulin secretion, decreased hepatic gluconeogensis and improved peripheral glucose uptake (7). This improved glucose utilization could lead to improved cellular metabolism and improvement in metabolic parameters of acidosis, especially lactate. In our study, we monitored glucose levels during hemorrhage and resuscitation and found elevated plasma glucose levels after hemorrhage, with reduction of these levels to baseline 180 minutes after resuscitation. However, there was no significant difference in these plasma glucose levels at any time point in rats treated with T0901317 versus vehicle-treated rats (data not shown). This implies that LXRα activation did not significantly change peripheral glucose utilization and the improvement in lactate was indeed a reflection of reduced cellular hypoxia in those rats treated with T0901317.
Decreased concentrations of total cholesterol occur early in course of critical illness, including major trauma and hemorrhage. Low cholesterol levels correlate with the severity of the systemic inflammatory response and high concentrations of pro-inflammatory cytokines (29, 30). Since LXRα is a master regulator of cholesterol synthesis, transport and catabolism (31), we also assessed plasma total cholesterol levels in rats subjected to severe hemorrhage and resuscitation. In contrast to clinical data, which report occurrence of hypocholesterolemia in critically ill patients, we observed that there was an increase of total cholesterol after hemorrhage and resuscitation as compared to basal levels of sham control rats. However, we found no significant impact on total cholesterol levels as a result of treatment with T0901317. This suggests that the anti-inflammatory effects of T0901317 are independent of its cholesterol regulating properties. The increase in total plasma cholesterol seen after hemorrhage and resuscitation in vehicle-treated rats is likely a stress response to severe hemorrhage, aimed at increasing the pre-cursors of cortisol biosynthesis. In support of this hypothesis, a previous study by Daull et al (32) showed a similar elevation of plasma cholesterol during the immediate resuscitative period following autologous blood transfusion amongst rats subjected to hemorrhage and resuscitation. Furthermore, a study by Abarca et al. (33) also showed an increase in plasma cholesterol levels of rats during the early phase of reversible circulatory shock induced by endotoxin injection.
Hemorrhage and resuscitation induces an inflammatory response that includes the infiltration of neutrophils into tissue (2). This infiltration is followed by the release of reactive oxygen species and subsequent tissue damage, which can ultimately lead to acute lung injury and even death (34, 35). Reduction of leukocyte adherence and infiltration into lung tissue has been found to improve survival after severe hemorrhage and resuscitation (36). In our study, we have shown a reduction in hemorrhage-induced neutrophil infiltration and lung injury as assessed by both histology and myeloperoxidase assay. Multiple studies have previously shown LXRα activation to reduce lung injury and neutrophil infiltration following infectious, LPS, or chemical insult to rodent lung (15, 16, 37, 38). Our study is the first report that LXRα activation affords lung protection following hemorrhagic shock. Thus, our findings suggest that LXRα activation not only limits inflammation in lung-specific models, but also exerts pulmonary protective properties during sterile non-infectious systemic inflammation.
Pro-inflammatory cytokine and chemokine release is a hallmark of the inflammatory response after hemorrhage and resuscitation (2, 4). This elevation leads to a systemic inflammatory response and organ dysfunction, including acute lung injury (34). Reduction of cytokine levels are therefore a therapeutic goal aimed at reduction of organ injury, especially pulmonary injury. Several previous studies have shown that LXRα activation reduces levels of these pro-inflammatory cytokines and chemokines after LPS or irritant insult both in vivo and in vitro. A recent study by Crisafulli et al. also shows the same reduction after splanchnic ischemia and reperfusion (11, 16, 19, 39). Our study confirms these results in a model of rodent hemorrhagic shock, with significant reductions in plasma levels of MCP-1, MIP-1α, TNF-α and KC. High levels of TNF-α have been associated with increased acute lung injury (34, 35). MCP-1, MIP-1α and KC are chemokines that induce chemotaxis of inflammatory cells (40–42). In our study, treatment with T0901317 induced a significant decrease of TNFα and several chemokines, in particular KC, which correlates with the observed reduction of lung neutrophilia and injury. Therefore, we hypothesize that LXRα activation abrogates neutrophil infiltration into the lung and subsequently limits parenchymal damage following hemorrhagic shock by limiting the production of crucial pro-inflammatory cytokines and chemokines.
NF-κB is a nuclear transcription factor that regulates the expression of a multitude of pro-inflammatory genes and has been implicated as a factor in the development of acute lung injury (17, 35). Amongst the pro-inflammatory cytokines up-regulated by NF-κB activation are TNF-α, KC, MIP-1α, MCP-1 and IL-6. In a previous study, we demonstrated that LXRα activation inhibits the LPS-induced inflammatory response of murine macrophages by inhibiting the NF-κB pathway (19). Recent in vivo models of spinal cord trauma and splanchnic ischemia and reperfusion have also shown a reduction in NF-κB activation after treatment with a synthetic LXRα agonist (39, 43). In our current model of hemorrhagic shock and resuscitation, we have demonstrated that treatment with T0901317 inhibits the early onset (i.e. at 60 minutes post-resuscitation) of NF-κB binding to DNA in the lung. The exact mechanism by which LXRα inhibits NF-κB activation remains unclear and appears complex. Activated LXRα seems to inhibit NF-κB/DNA binding while also inhibiting the transactivation of NF-κB already bound to DNA. For example, earlier in vitro studies have shown that activation of the NF-κB pathway in LPS-challenged macrophages is inhibited by LXRα activation, but failed to show a decrease in NF-κB binding to DNA (10, 11, 15, 44). Ghisletti et al. support this finding in their study, showing that LXRα activation of macrophages prevents the clearance of co-repressors in a SUMOylation dependent manner, thus preventing the transcription of several pro-inflammatory genes (45). This trans-repression would decrease the transcriptional activity of NF-κB without altering its binding profile. However, in vivo studies of splanchnic ischemia and reperfusion did show a reduction of NF-κB binding to DNA, similar to the findings we report in this study (39). This suggests that LXRα does block NF-κB binding to DNA and subsequent transcription of pro-inflammatory genes in in vivo models or in models of ischemia and reperfusion. However, the exact mechanism remains unclear and further investigation is needed to define the precise role activated LXRα plays in inhibition of the NF-κB pathway in vivo.
In conclusion, we have shown that activation of LXRα with the synthetic agonist T0901317 improves the hemodynamic profile and reduces lung inflammation after hemorrhage and resuscitation in a rodent model. The reduction of inflammation is consistent with inhibition of NF-κB binding during the early phase of shock. Further studies using inhibitors of LXRα, such as GSK 2033 (46), or transgenic mice deprived of the functional gene for LXRα (14) will establish the precise mechanisms of LXRα and NF-κB interaction.
This investigation was supported by the National Institutes of Health (R01AG-027990 to Dr. Basilia Zingarelli). Dr. Patrick Solan was supported by a National Institutes of Health training grant (T32 GM-008478).
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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text: Aeration Industries International (AII) 4100 Peavey Road , Chaska , MN 55318 USA premium About Solutions applications industries Publications videos articles Latest news Downloads Companies Aeration Industries International (AII) Articles 14 Articles found Articles indicates free access Sugar Beet Harvest Simplified with Aire-O2 Tritons Overview: Sucrafor, a COSUMAR Groupe sugar beet processing plant in north east (Oriental) of Morocco, North Africa, designed a wastewater treatment plant to maintain high organic loads through anaerobic, anoxic, and aerated lagoons; ... Sep. 6, 2017 Sugar Beet Harvest Simplified with Aire-O2 Tritons - Case Study Overview: Sucrafor, a COSUMAR Groupe sugar beet processing plant in north east (Oriental) of Morocco, designed a wastewater treatment plant to maintain high organic loads through anaerobic, anoxic, and aerated lagoons; as they crush more than ... Dec. 23, 2016 Reliable Aeration Offers Foundation for Growth & Sustainability at Pacific Reef Fisheries Overview: Pacific Reef Fisheries (PRF) has been a valued Aeration Industries International (AII) client dating back to 2003. John Moloney, General Manager of PRF and Vice President of the Australian Prawn Farmers Association, has been with PRF ... Nov. 15, 2016 Marcos Kroupa Singapore: red Tilapia spawns profits At this research and commercial farm, freshwater red tilapia (Oreochromis , spp.) is a major product, selling live for a premium price. Harvest size is 600 to 700 grams each, following a six month grow-out period. The senior manager reported, ... Nov. 19, 2009 Thailand: Successful intensive shrimp farming Thailand Historically, Thailand is one of the leading shrimp producing countries in the world. And, growing numbers of Thai farmers depend on AIRE-O2® aeration for water quality management. This major Penaeus monodon farm chose the AIRE-O2® aerators, `for ... Dec. 22, 2008 Indonesia: Opportunity for shrimp aquaculture Great opportunities exist in shrimp culture in Indonesia due to land availability and ideal climate. Already, this country is one of the largest producers in the world. Many farmers use AIRE-O2® aerators as their `aerator of choice` because the ... Dec. 22, 2008 Malaysia: Strong demand for ornamentals The ornamental fish cultured at this Malaysian farm are exported primarily to the U.S.A. The average stocking rate in the 100 ponds of varying size is 10,000 pieces. Survival is 70 to 80 percent. Factors such as size, color and species set the ... Dec. 22, 2008 Tahiti: Shrimp intensification excellence Advanced techniques for super intensive shrimp cultivation are common in Tahiti due to researchers high-tech expertise on this land-limited island. Most farms are stocked with Penaeus vannamei or P.stylirostris shrimp at densities of 100 to 120 ... Dec. 22, 2008 Jamaica: Tilapia pioneer expands Since 1983, this red tilapia farm has been using AIRE-O2® aerators in its grow-out ponds, which produce millions of pounds of fish per year for the Jamaican market and for export. In a1990 interview, a manager at the farm said, `We have AIRE-O2® ... Dec. 22, 2008 Minnesota, USA: A challenging climate for fish Icy winters and hot summers resulted in fish kills at this Minnesota farm raising walleyes, muskellunge, black crappies and northern pike. In winter, ice and snow on the pond's surface caused dissolved oxygen levels to drop below 5 ppm, stressing ... Dec. 22, 2008 Colombia: Tilapia venture doubles yields The first red tilapia farm in Colombia, South America gained government approval as a `high priority project` due to its exportation goals. Since its start-up, production rates have doubled with the addition of AIRE-O2® aerators. Stocking densities ... Dec. 22, 2008 Portugal: P. Japonicus shrimp venture breeds profits An experimental venture into the P. Japonicus shrimp business has yielded good profits. The shrimp's market prices are four times better than for P. vannamei , more common in Portugal. The owner believes water quality management is critical. He uses ... Dec. 22, 2008 Asian dairy churns out grade AA effluent ` The AIRE-O2® aerators have excellent oxygen transfer, easy maintenance and operation.` Problem Founded in 1937, this dairy cooperative located in Asia has played a leading role in the development of the industry in its country. Its mission is ... Dec. 22, 2008 The air is sweeter at winery The angle of operation can be adjusted for the shallow ponds Problem `Crush` season was a challenge for this California vineyard, creating severe wastewater treatment problems. Biological oxygen demand (BOD) loadings peaked at excessive amounts. ... Dec. 22, 2008


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One day after a prominent US Muslim leader reacted to the November 2015 Paris attacks with a declaration that the Islamic State, also known as ISIS, has nothing to do with Islam, President Obama made the same assertion. Who exactly is the enemy we face, not only in the Middle East but also within our borders? Is it "murderers without a coherent creed"; or "nihilistic killers who want to tear things down", as some described ISIS after 130 people were brutally slain and another 368 injured in a coordinated attack on Western soil that authorities say was organized with help from inside France's Muslim communities.
After the Paris attacks, Obama himself, described ISIS as "simply a network of killers who are brutalizing local populations." When the Department of Homeland Security was founded in 2003, its stated purpose was "preventing terrorist attacks within the United States and reducing America's vulnerability to terrorism." The Bush administration's definition of the enemy as a tactic, terrorism, rather than a specific movement, proved consequential amid a culture of political correctness. By the time President Obama took office, Muslim Brotherhood-linked leaders in the United States were forcing changes to national security policy and even being invited into the highest chambers of influence. A policy known as Countering Violent Extremism emerged, downplaying the threat of supremacist Islam as unrelated to the religion and just one among many violent ideological movements.
When recently retired DHS frontline officer and intelligence expert Philip Haney bravely tried to say something about the people and organizations that threatened the nation, his intelligence information was eliminated, and he was investigated by the very agency assigned to protect the country. The national campaign by the DHS to raise public awareness of terrorism and terrorism-related crime known as If You See Something, Say Something effectively has become If You See Something, Say Nothing. In See Something, Say Nothing, Haney, a charter member of the DHS with previous experience in the Middle East, and co-author Art Moore expose just how deeply the submission, denial, and deception run. Haney's insider, eyewitness account, supported by internal memos and documents, exposes a federal government capitulating to an enemy within and punishing those who reject its narrative.
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Rolex Lady Datejust
Own this watch at an EMI of ₹62,290
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Rolex was the first brand to gain success in achieving Chronometric Precision. Founded by Hans Wilsdorf, the brand is known for its innovative designs and high tech construction.
The M179171-63131_ Wht 10Br Lady Datejust is a watch made by Rolex that is an instant eye catcher. This watch's case is made of Everose Rolessor, a harmonious mix of 18 karat Everose gold and steel 904 L. A fluted bezel mounted on the case is characteristic to Rolex watches, and is an impressive part of the watch design. Its dial is white in colour providing a sense of absolute serenity. The hour indexes are represented with the help of Roman numerals and are of the same tone as that of the bezel.
A Sapphire Crystal over the dial offers protection to the timepiece. This glass is highly scratch resistant and a patented technology of Rolex. The date window at 3 o'clock has a Cyclops lens over it, which helps to magnify the date by 2.5 times its actual size, thus providing an easy view of the date. The bracelet of the watch has a three link type construction. An easy folding clasp offers security and bears the Rolex logo in full glory.
Tagged as a Swiss certified chronometer this timepiece works with exceptional efficiency. It means that this watch has been tested under extreme conditions, in different places and at different times to prove its precision. Featuring a perpetual self-winding mechanical movement, this watch uses a bidirectional perpetual rotor that runs the watch. It is also water proof to a depth of 330 feet or 100 metres. This is made possible by screwing the bezel and the casing down in such a manner that the watch is clamped shut like an oyster's shell. Every Rolex timepiece in the Oyster Perpetual series is made absolutely water resistant this way.
The Lady Datejust collection by Rolex is the first ladies version of the Datejust timepieces launched in 1957. These watches carry the Rolex heritage of timeless functionality and elegance and feature a more compact size, perfect for a slender, feminine wrist.
The watches from this collection are crafted in 18 carat gold, 904L steel, or platinum studded with gems to suit a diverse mix of connoisseurs. They have a date window at the 3o'clock position and feature a date-change mechanism, which was adapted in 1955, that renews the date within a few thousandths of a second at the stroke of midnight. A Cyclops lens adorns the window, magnifying the digits two and half times for ease of viewing. The finest sapphires, rubies, and emeralds are used by Rolex to adorn these timepieces. These stones are sorted by hand to prevent variations in colour and are scrupulously inspected by experienced gemologists for authenticity and quality. The purest and most resilient metals are used to craft the watches. Exquisite Yellow, white, and pink golds unique to Rolex are obtained by adding proportions of platinum, copper, and silver in the in-house foundry. These watches have president metal bracelets with three-piece semi circular links. There is a concealed Crownclasp fitted at the end, giving the watches a seamless finish. A self-winding mechanical movement, caliber 2235 powers the Datejust Lady watches. The caliber is a certified Swiss chronometer- a title given to select watches that meet the rigorous standards set by the Swiss Official Chronometer Testing Institute (COSC).
Anoushka Shankar, the queen of sitar and a classically trained musician, is a prominent brand ambassador.


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Over ten thousand people take part in our events every year. Whatever your sense of adventure or fitness level, Dryland has an event that speaks to you.
That's why people are making Dryland events a priority on their annual calendar.
Dryland owns and operates eleven mountain biking and trail running events, nationwide.
Momentum Health Attakwas Extreme presented by Biogen
Start: Oudtshoorn
Finish: Great Brak River,Mossel bay, Western Cape, SOUTH AFRICA
South Africa's premier one-day race will stage its 12th edition in 2018 – nearly twelve years since that inaugural event in 2007, with a start list then, shorter than the current crew list and with no idea where this would take them, Dryland took this task to hand. South African's and their appetite for tough endurance events projected the Attakwas into legendary and cult-like status over the next couple of years; this is the race to do if you want to test mind, body and machine!
Spur Attakwas Mini
Start: Pine Creek Resort, Great Brak River, Mossel bay
Finish: Pine Creek Resort,Western Cape, SOUTH AFRICA
This race is targeted at the "not so fit" rider or someone brand new to the sport – designed to thrill and excite without the serious effort of the extreme event, even though the last 15 kilometers is shared by both events. The mini starts of with challenging climb out of Great Brakriver towards the plateau that overlooks the beautiful bay of Mossel Bay. Riders work their way towards Jonkersberg on undulating farm roads until they reach Jonkersberg Forestry station. From here the most scenic of jeep track follow the contours of the southerly slopes of the mighty Outeniqua Mountains.
Momentum Health Tankwa Trek Presented by Biogen
Western Cape, SOUTH AFRICA
In 3 short years the Tankwa Trek has become SA's premier 3-day stage race – this is racing proper through some of the most scenic areas of the land. Three stages, 3 different route designers and a monster of a mountain coupled with some of the best single track on offer in the Western Cape makes this the race to do. This race boasts an astonishing growth of over 300% over the first 3 years since inception.
For more info visit: www.tankwatrek.co.za
Tankwa Trail
Kaleo Farm, Ceres,
Western Cape, SOUTH AFRICA
Runners taking part in the historic Tankwa Trail will be the very first to experience the Koue Bokkeveld from the vantage point of a trail run.
This is the heart of deciduous fruit country, a region known for its unforgiving summers and harsh winters, trails through rocky outcrops, climbs steeper than the imagination, descents with a wicked technical twist and views to cherish forever.
Trails – some hand built and smoothly sculpted, others rough and loose – always reward the adventurous. Join us this summer and experience the run of a lifetime!
For more info visit: www.tankwatrail.co.za
36ONE MTB Challenge
Klein Karoo,
The 36ONE MTB Challenge offers everyone who enjoys cycling a chance to participate in the ultimate single-stage mountain bike race in South Africa. For those of you new to mountain biking who want to enter as a relay team, or endurance athletes who enjoy the long-distance challenge – this event caters for you.
Family, friends, spectators and back-up personnel can access the route at all checkpoints and cheer riders along. The route will be well marked and marshaled with no navigation required. Imagine the elation and the sweet taste of achievement when you cross the line.2016 Results
For more info visit: www.the36one.co.za
Glacier Cradle Traverse
The exquisite Avianto Lifestyle Estate set alongside the Crocodile River, only 30 minutes from the city and 10 minutes from Lanseria Airport, will play host to what is set to become the premier mountain bike event on the Gauteng race calendar. This 3 day stage race will include never-before ridden areas in the Cradle of Humankind, Muldersdrift, as well as tracks in adjacent estates and conservancies. Join us from 5-8 April 2018 for a race like no other…
For more info visit: www.cradletraverse.co.za
Glacier Storms River Traverse
Eastern Cape, SOUTH AFRICA
The Tsitsikamma Village Inn situated in Storms River Village – The beautiful and untouched gem of the Garden Route, will host riders on this 3-day mountain bike stage ride. With tracks hugging the rugged coastline and views only seen on postcards, this ride is designed around the intermediate cyclist looking for an adventure without having to spend hours training every day. The daily distances range from 40-70 kms and will traverse the mountains, plantations and coastline adjacent to the Village. Tsitsikamma Village Inn was originally established in 1946. It is a privately owned and managed country hotel consisting of 33 village-style and 16 log rooms built around a Village square, the Race Venue. Storms river Traverse is a family oriented race as children are accommodated and catered to on the venue.
For more info visit: www.stormsrivertraverse.co.za
Ladismith Cheese 7Weekspoort MTB Challenge
This race has become synonymous with Ladismith and is now already a long standing fixture on the annual "things-to-do" calendar of this Karoo town. Ladismith literally opens its doors to the crowds of out-of-towners that flock to the race and the Ladismith Cheese 7Weekspoort race contributes so much to the local economy, no one more than the title sponsor, Ladismith Cheese. The event consists of 3 events from a easy meander through the foothills of Towerkop mountain to the more challenging ride through the iconic Seweweekspoort.
For more info visit: www.7weekspoortmtb.co.za
Momentum Health Cape Pioneer Trek, presented by Biogen
From the arid deserts capes of the Groot Karoo to the great mountains of the Klein Karoo and the aboriginal forests of the Garden Route, the Cape Pioneer has it all, a truly African mountain biking experience. The magic lies in the unique combination of exciting, diverse trails, passionate people and authentic human connection, brought to you by world class event organisers.
The result is a race that has achieved near legendary status.
For more info visit: www.capepioneer.co.za
Dryland Traverse
The Dryland Traverse is a 4 day Mountain Adventure Stage trail run covering 88kms which takes place in the Klein Karoo, South Africa. From the arid, dry semi-desert of the Groot Karoo, to the hilly passes and lush vegetation of the Klein Karoo, the Swartberg mountain range showcases diversity. Starting in the deep chambers of the Kango Caves, runners traverse jeep and single tracks, waterfalls and pass the precisely engineered National Monument. All packages include: 4 stages and 3 night's accommodation, official race apparel and all meals.
For more info visit: www.drylandtraverse.co.za
Attakwas Trail Run
The infamous Attakwas kloof has for far too long been frequented only by mountain bikers – the time has come for the trail-runners to get their bite of the action. In November Dryland Event Management launches the inaugural Attakwas Extreme and Attakwas Mini trail runs. Nowhere else will you find a more diverse trail route, starting in the Karoo and finishing at the coast catering for all levels of runners. Do not miss this one, entries will be hard to come by.
For more info visit: www.attakwastrailrun.co.za
Dryland Ride
Lesotho & Namibia.
Dryland Ride brings adventure back with mountain bike tours for riders of all levels, through some of the most majestic country in South Africa.
You can choose: Will it be the cool, dense forests and contoured mountain paths of the Garden Route or the rugged passes and ravines of the two Karoos?
Either way, it's a childhood dream revived – a 4-day MTB ride that brings the fabulous diversity of South Africa within reach of everyone.
For more info visit: www.drylandride.co.za


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Our Approach
Why We Need a New Approach to Science
According to reductionist approaches in science the human organism can be explained entirely in terms of its individual, constituent parts and their interactions. To explain something means to break it into parts, the smaller or more basic the better.
The field of nootropics and cognitive enhancement has largely followed reductionist tendencies. Research has proliferated. There is truly a wealth of scientific findings focused on individual neurotransmitters, mechanisms, parts of the neurotransmission cycle, cell walls, receptor sites, brain/blood flow, and hundreds of other isolated variables.
Lots of parts…lots of "findings" and "mechanisms." But no meta-theory of the complex interactions that make up the whole. Many various disconnected insights will always fall short of addressing the complex dynamics of interacting parts. Too many products are developed to narrowly optimize one aspect of our cognitive capability, only to have unexpected drawbacks and impacts on others.
NHC is developing a fundamentally novel approach. We are bringing together the best scientific research on each individual mechanism and pathway supporting cognitive development, and integrating them into a whole systems view; a complex framework of integrative neuroscience.
By performing a principled meta-analysis and synthesis of existing research, we can better understand the complex dynamics and emergent homeostatic relationships within the brain. From these kinds of insights we yield a truly advanced complex meta-theory of cognitive enhancement. This is the basis for the best nootropic stacks ever made.
Understanding the System: The Theory
A whole systems approach to the mind/brain interface requires stepping back and capturing every relevant factor. You have to examine the psychological, neurological and pharmacological dimensions themselves as complex systems and how each of these interacts with and feeds back on the others. You want to note and take advantage of synergetic relationships and how even small changes can lead to negative externalities to be avoided (called "side effects" by some folks). You have to carefully account for the particularities of how different chemistries interact with the body, and with each other, and then use all of this modeling to select just the right balance of form and dosage with each ingredient.
Complex systems are famously sensitive. Failure to account for the whole system can drive short term effects at the cost of damaging long term equilibrium. But, if you can develop a true whole-systems approach, you can move the entire system into a higher homeostasis.
A Snapshot of Applied Neuropsychopharmacology
We performed a comprehensive analysis of neuroscience research to determine the underlying regulatory hardware responsible for mediating our desired subjective and performative effects. Our approach seeks to support all those physiologic pathways and processes, with the goal of evolving a more robust and complex neural network and regulatory system functioning.
Meet QUALIA
Qualia is the most comprehensive, effective cognitive enhancement nootropic in the world. With 42 scientifically researched ingredients, Qualia's formulation has been designed to amplify all the aspects that matter most for optimal cognitive and nervous system functioning. It works by supporting the core underlying regulatory mechanisms of the brain and body that mediate our conscious experience.


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AA (8-10 year olds)
May 09 - Sep 09
Ages 8-12
Meeting Dates
From May 10, 2016 to Sep 10, 2016
About This Activity
AA Baseball is for boys and girls 8 - 10 years old. All players hit in batting order. Player development is continued, focussing on fielding through proper positioning and decision making.
Organizer Info
Rancho Bernardo Little League


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Heritage Body and Frame Pond Springs
Review for Heritage Body and Frame Pond Springs
Charles C. on 04/05/2013
Charles said this business did a good job and they did the work promptly. He said the personnel were very pleasant.
Category: Collision
Service Date: 03/25/2013
Review Created: 04/05/2013
This review was collected via phone interview by Customer Research Inc.


text: About the space Perfectly located between Circular Quay and Martin Place, we are located in the heart of Sydney CBD. Our central location makes it easily accessible for clients and members alike. Circular Quay 400m, Wynyard 500m, Martin Place 650m There are numerous buses that service the area. Please check your best route. Circular Quay 400m Storage available Best co-working space in Australia In 2017, Tank Steam Labs won, the best co-working space in Australia by Fin Tech See for yourself what TSL has to offer. Our modern office spaces are simply stunningCome take a tour and see for yourself.Take the 360 tour Coworking at Tank Stream Labs Some of our facilities


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Greenville Technical College academic schedule
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Find info concerning Greenville Technical College academic schedule, and registering for elective seminars and lectures. As a student, your first stop should be the registrar's office, where you can pick up a free copy of both the academic calendar and course catalog, in order to find available credit classes that you may be interested in taking. In-person class registration has largely been replaced with online sign-up, and many schools offer mobile apps that streamline the course registration process. Finally, check with the admissions office for assistance with prerequisites, tuition payment deadlines, and Greenville Technical College class registration information. Please use the form above to request admissions info for Greenville Technical College.
Research demonstrates that college freshman taking a full courseload go on to complete their degrees at a much higher rate than those students who study part-time. When choosing a major, plan ahead and be sure that you are picking courses that will meet transfer requirements of other colleges and universities later on. Further, by choosing your major early, you may be able to take some required core classes in a community college, saving both time and tuition fees.
Look at all the schools in your state first, as in-state tuition may be lower for state residents. The course catalog will outline which classes are required for a particular major, and what minimum GPA you'll need to maintain your class standing. Please contact the academic advising staff at the school you are interested in applying to about their specific course registration guidelines. Beyond degree requirements such as Greenville Technical College academic advising, you may consider Saint Paul College conferences for complementary electives to your primary course of study.
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American Arithmometer Headquarter
January 20, 1886: Inventor William Burroughs and three other men founded the Arithmometer Company in St. Louis on this date. They were selling their new invention, the adding machine.
This post was contributed by Joe Sonderman. Joe has written many books on Missouri and Route 66 history. You can find his books on Amazon.com and on 66postcards.com.


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Strep Suis Identified as Top Reason for Calling Vets to Swine Farms19 February 2013
Manitoba Pork Council and Sask Pork
FarmScape is a Wonderworks Canada production and is distributed courtesy of Manitoba Pork Council
and Sask Pork.
CANADA - Information collected through the Canadian Swine Health Intelligence Network suggests more attention should be paid to strep suis, writes Bruce Cochrane.
Launched on behalf of the Canadian Swine Health Board in July 2012, the Canadian Swine Health Intelligence Network allows swine veterinarians across Canada to share information on disease issues developing in their regions.
It can affect baby piglets all the way through to about eight to ten weeks old.
In the network's latest quarterly review, streptococcus suis and other strep infections have been identified as one of main the reasons veterinarians were called to farms.
Dr Chris Byra-Canadian Swine Health Intelligence Network
Infections later are more rare and it can sometimes cause an overwhelming infection and kill the pig.
One of the common symptoms is meningitis but it also can cause arthritis and a few other conditions.
The organism is passed from the mother to the piglets and in most cases they develop immunity to it.
If too much of it is picked up by any particular piglet some die from it, some end up with meningitis and there's some other conditions.
In the autumn we often get a flare-up of this disease and it is related to temperature fluctuations.
This year, particularly in eastern Canada but right across the country, we've seen much more variation in temperature going from plus 10 to minus 20 quite quickly and it's very difficult to ventilate barns under those conditions.
Also trucking pigs could have that similar effect under those conditions. Dr Byra says the trend confirms what veterinarians already knew about strep suis and probably indicates we should be putting more efforts into control.
It can affect baby piglets all the way through to about eight to ten weeks old.
ThePigSite News Desk


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Logged In: YES
I'm checking on this to see how it can be done.
Blat ist great and hey there is a BLAT.DLL also availible -
What about enhancing tht DLL to register it as Object
with REGSVR32.DLL so we can simply use it with
VBScript as Object ?
There are a lot of VBScripts out there to compile a
commandline and to start blat.exe with the Wscript.shell
It would be great to use BLAT as an object and use it
similar to the CDO.Object of Microsoft (but without an
SMTP-Server, Outlook or Exchange on the machine)
Set objMail = CreateObject("Blat.SMTPMail")
Set objMail = CreateObject("Blat.NNTPMessage")
and that adding all properties etc.
Any plans to enhance the DLL like that ?
It would make BLAT to the ultimate SMTP-notification
for VBS-Script Admins
Frank Carius.
Logged In: YES
I'm checking on this to see how it can be done.
Logged In: NO
any news on this ?
Log in to post a comment.


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Hello GVHrs
We will be having our first Club Meeting of 2016 this coming week.
Date: Tuesday, March 1st, 2016
Time: 7:30 pm
Location: Steve's Pizza in Downtown Davis
Items we will be discussing:
1. Labor Day Race
2. GVH Retreat
3. Members recruitment
4. Fundraising
5. Monthly Group Trail Runs
6. Fees/Listserve clean up
If there is anything else any of you would like to discuss that is not already part of the listed items, please send me a detailed email (firstname.lastname@example.com) on what you would like to add to the list.
Also, if you haven't done so already, please fill up the Retreat Survey that was sent out over the weekend. We would like you to answer the survey at this link.
Thank you,
Cristina R. Ramirez
Welcome! > Announcements >


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old GROUP OF 15 VINTAGE POCKET KNIVES - REMINGTON, CASE
Sold for:
Start Free Trial
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- Sold Date:
- Source: eBay
Up for auction is this group of 15 vintage pocket knives. We have an ULSTER TL-29 Unused and ETCHED. A GEO. WORTHINGTON, a ROBESON POCKETEZE, a bone REMINGTON, a CAMILLUS 4 line peanut, a WESTERN (broken spring), An etched CRAFTSMAN, a CASE TESTED XX rough black, and others. Collectors, users, or parts knives, all in various conditions. Please see the pictures. I will be selling over 100 vintage knives in groups over the next several weeks with conditions ranging from excellent to parts knives. Please email in case you have questions or concerns before bidding. Take a look at my other auctions for some more fine vintage knives this week. Thank-you and Good Luck!


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Lot 80 of Whitewater Wilderness Ranch Sub-Division has gentle rolling terrain with several building sites throughout the acreage. Property is surrounded on 3 sides by year around association maintained roads. Great Horse property. The Ranch is surrounded by wildlife and ranch owners enjoy gated access to public lands. Power and phone to the lot line.
Data Provided by Mountain Central Association of Realtors


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Bellanage Peel – Bella Rosa Rejuvenation Clinic
The Bellanage Peel is a superficial chemical peel designed specifically to treat uneven pigment, such as post-inflammatory hyperpigmentation and melasma, and mild texture problems on the face. Unlike laser and IPL treatments, the Bellanage Peel can be used safely and effectively on all skin types.
Traditional laser and chemical peel treatments have not been beneficial for clients with darker skin. The Bellanage Peel is unparalleled in its ability to safely target pigment and texture issues for all skin types, without unwanted side effects commonly seen with other treatment options.
How It Works:
The system consists of two parts: a masque applied by our medical staff and an after care medical-grade product regimen provided at your appointment. During your office visit, your masque/ peel will be applied. The masque is a thick, white substance that takes about 20 minutes to apply. Although it is not painful, it must be worn for up to 10 hours before it is removed.
The product regimen consists of medical-grade skin care products which are included in the price of the Bellanage Peel. The regimen is started as soon as the masque is removed. The Bellanage Peel is similar to the "Melanage" Peel, except we add an extra moisturizing step to the product regimen that speeds up recovery time.
We will see you in the office for a 2 and 4 week follow up visit to evaluate your recovery and outcome. At your 4 week visit, your Bella Rosa service providers will outline your custom skincare plan to maintain your results.
Expected Outcome:
Most clients experience significant peeling of the skin starting at day 2-3 post treatment. Resolution of skin peeling usually occurs by day 5 post treatment. Sensitivity and redness are common beginning day 2 post treatment, which are soothed with the products included in the products regimen. Dark spots and hyperpigmentation will significantly lighten after one treatment, and pore size, fine lines, and mild texture concerns will improve dramatically for most clients.
Below are reasons to avoid or postpone having a Bellanage Peel:
- If you have an active cold sore or warts, open wounds, sunburn, excessively sensitive skin, dermatitis or inflammatory rosacea in the area to be treated
- If you have a history of herpes simplex, be certain to inform the doctor
- If you have a history of allergies and rashes, skin reactions or sensitivities
- If you have taken Accutane within the last year
- If you have received chemotherapy or radiation therapy in the last year
- If you are breast-feeding
For more information on the Bellanage Peel, or to schedule a consultation, please call Bella Rosa today at 713-383-ROSA (7672) or email us via our contact page.


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New Spidey Director Jon Watts On Spidey & The Reboot
New Spider-Man reboot director Jon Watts spoke with Superherohype.com about his own familiarity with Spider-Man and also gives a small update on starting work with the reboot's writers, John Francis Daley and Jonathan M. Goldstein.
On his own history reading comics and Spidey:
Watts told us his own history with the character that made him so excited to land the gig. "I had this learn-to-draw Spider-Man comic book. There were some panels that were blank panels for you to fill in the rest of the story and then some that were just pencils for you to ink and then there were some that were already inked for you to color to decide if you want to be the penciler or the inker or the colorist or the writer. I was obsessed with this book. I would bring it to school every day until I had slowly filled up and colored every panel and then after that, it was the Todd McFarlane era, his run which was so cool. That's when I was really into comics, but now it's just been really great to hang out in an office and read comics all day, catching up on everything that I've missed."
On working with the film's writers:
Watts has only just started working with writers John Francis Daley and Jonathan M. Goldstein (whose directorial debut Vacation was released this past weekend). Though Vacation is very different than Cop Car, they do both involve cars and driving, but other than that it's hard to see how their sensibilities might come together on a Spider-Man movie. "We're all learning about each other, but they're very, very smart and extremely irreverent and I can't wait to start," Watts told us. "I should be working on it right now and not doing a bunch of Cop Car interviews probably."
–George Berryman!


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Is it any wonder that 2 out of 3 Catholics no longer believe in the Real Presence of our Lord in the Blessed Sacrament?
In a news article of August 22, 2011, CNA purported to give an explanation for the responsorial acclamations by the laity to the 'Mystery of Faith'. According to the article, "[the] acclamation that responds….gives the assembly voice in the middle of the Eucharistic prayer" and "each [acclamation] recapitulates the deep mystery of our redemption by means of our Savior's cross and resurrection".
The acclamations – after the revisions of 2011 – are:
"We proclaim your Death, O Lord, and profess your Resurrection, until you come again."
"When we eat this Bread and Drink this Cup, we proclaim your Death, O Lord, until you come again."
"Save us, Savior of the world, for by your Cross and Resurrection you have set us free.
Well, the words in the Canon, 'Mystery of Faith' were never meant to "recapitulate" the deep mystery of our redemption by the death of our Lord!
Rather, according to sacred tradition – which St. Alphonsus Liguori teaches is the guardian of Catholic truths – the expression is meant to spotlight the dogma of our faith in the Real Presence! The saint, in his book The Holy Eucharist, quotes Pope Innocent III (1198 – 1216): "Quoniam aliud ibi cernitur, aliud creditor." (We see one thing, and believe another.)
The words of Consecration in the Canon of the TLM, are by Apostolic tradition, attributed to Our Lord Himself, says Innocent III. Their meaning, as the Roman catechism teaches (Council of Trent), is that bread is no longer bread, but the Body of Christ; wine is no longer wine, but the Blood of Christ.
As for "giving voice to the assembly", the faithful were once taught to look upon, and silently adore the elevated Sacred Species with the expression of faith, "My Lord and my God!"
In the words of the late Michael Davies, "[T]he exodus of young people from our churches has been one of the most dramatic manifestations of the 'Conciliar Church', but as the nature of their true birthright is something of which they are kept in total ignorance they are hardly likely to lament its absence."


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Results 1 to 2 of 2
03-14-12, 02:22 #1Registered User
- Join Date
- Mar 2012
- Posts
- 4
Unanswered: Failed to add record to table attrib
I am using an Informix DB with telleogic and during the unpack of the cpk file i am able to create the informix DB in dbspace ccm but i get the below error
ERROR: Failed to add record to table attrib(-603), terminating
ccm_gzip: stdout:broken pipe
Error: Cannot load database.
And with this it deletes the informix Db that is created and all the files as well.
please help me in this regard as this server is in production.
03-14-12, 05:03 #2Registered User
Provided Answers: 1
- Join Date
- Sep 2011
- Location
- Pont l'Abbé, Brittany, France
- Posts
- 392
You look to be running out of disk space.
Can you please answer my former question so that we can find a solution


text:
Who Else Wants to Discover the Amazing Secret to Living Simple Stress-Free?
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Veronica Bettencourt
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In fact, right now, for a limited time, you can take advantage of a special promotional offer and receive Simple and Stress-Free Living" for just $19.99 the regular price is retailed at $29.99 !!
Oh, and don't forget the 2 bonuses that I am offering you valued at $19.99 each. They are yours free when you order today - That's 3 ebooks for the price of 1 for a total retail value of $69.97!
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Veronica Bettencourt
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Transparency international report on corruption in Pakistan 2016
ISLAMABAD: Pakistan's positioning in the Corruption Perceptions Index (CPI) 2016 has enhanced and the Transparency International (TI), which discharged the report on Tuesday, has communicated the trust that Islamabad will work all the more vivaciously to battle the danger.
The TI depicted Pakistan's CPI score of 29 out of 100 and positioning of 126 among 175 nations as the best. The nation has never accomplished this refinement since the principal CPI was issued in 1995.
Transparency international report on corruption in Pakistan 2016
Pakistan had secured the score of 28 and was positioned 127th among 177 nations in 2013, as per insights discharged by Berlin-based non-benefit association focused on advancing responsibility, trustworthiness and straightforwardness.


text:
Models For Decoration Panel-
Decoration Panel- by Electrolux
£37.65 Out of Stock
Email me when back in stock - we'll try to re-stock quickly!
The product Decoration Panel- is suitable for the models listed below.
View full product details for Decoration Panel-.
Search our range of models by entering your model number to perform a search.


text:
Tag Archives: w-2
2016 in work and money
This post leaves me dissatisfied with pie chart makers and is as much a note to myself as anyone else who will read it. Last year was a weird year for work. I picked up a bunch of odd consulting … Continue reading


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When we see or hear the word "free" our face instantly just brightens up. Be it a sale or a trick to fool one, the word free does grab some quick attention. Are you wondering what this has to do with regards to improving your health?
Well, we here to share some of the free ways or tricks that you can use to improve your overall health and well-being.
Check out for the list of things that you can do and improve your overall health instantly without any hassles.
Dieting is not the only option to lose weight. With a smart way to change your lifestyle, you can always improve your health by trying some other easy options too. These little changes can even help improve your immunity level.
So, check out for the list of things that you can do to improve your overall health. We suggest you try each of these and watch how you'll transform yourself into a better 'you'.
Confused? Well, it is very important that our body needs to take rest. It also does not cost a thing. It is said that less sleep increases the risk of various health issues, including blood sugar imbalance, high stress level, obesity and mental problems. To avoid these, it is better you have a sound sleep of at least 8 hours each night.
A Calm Mind
The more you are stressed, the more there are chances of your health going for a toss. Hence, it is better to avoid being stressed. Having a calm mind will help you improve your immune functioning, reduce physical pain, increase memory and improve your heart rate. Is there a better way to stay healthy than this one?
Hug Somebody
When you hug a person whom you love, the body tends to produce feel-good hormone known as oxytocin. This helps to ward off depression. This is one of the most simplest ways to improve your overall health and well-being.
Eat A Large Salad
You do not have to bother much about your meal as long as you eat a large bowl of salad. This keeps you feeling full with a healthy dose of veggies, and you end up eating less of the main course.
Deep Breathe
This is the basic thing that we all do; and of course it is free. Be a little mindful by taking deep breathes each morning. This helps to reduce the stress and helps clear your airway passage as well. It also helps to reduce the anxiety level, improve your sleep and maintain a good health.
Start your day with a big glass of lemon water and do drink water every hour. When the body is hydrated, it functions well. Studies reveal that most of the body aches, pain or headaches can be instantly relieved by consuming a good amount of water.
A Walk In The Park
As we all know, only dieting is not going to help you solve your issue of losing weight. You'll also have to do those regular body exercises or go for a nice peaceful walk in the park. This can definitely increase the feel-good hormone in your body.
Eat Fruits
Consume fruits whenever possible; however, make sure not to eat them after your dinner or late during the night. Having fruits during the early part of the day can help us control our hunger pangs effectively.
If you have any suggestions, do share them with us in the comment section below.


text: formless void <email@example.com> wrote: .> I believe that Microsoft its interal quality control .> system is very strong but the product has to be QA-ed .> by an external representativ of the authority >What authority? AFAIK there is no FCC equivalent for software. >Andrei formless, are you inferring you would argue for such an authority to be set up? This is a good point, but get M$ to agree to it. Good luck. Kind Regards, B.Hoffmann Linux User #398054 -Foresight Linux- -Ubuntu- -Debian (Sarge)-


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Every detail of your home reflects your personal taste, personality and style.
At Majestic Hardwood Floors, we stand ready with a full array of services and advice to help our customers achieve their unique design visions. We have a variety of stains available that can be used to enhance or even alter the natural color of wood floors, and we also provide bleaching services to lighten the wood's color.
The last 10 years has been a period where "natural" finishes were used extensively. Over time, most floors yellow with age, and have a "dated" appearance. Even though the floor and finish are in good condition, they just don't match the rest of the décor. A stain will often provide an entirely new look, and stained floors tend to be more color-fast than natural floors
The time-consuming and skill-intensive staining process is critical to customer satisfaction. We offer almost any stain color available on the market today and have extensive experience in preparing custom-mixed stains and matching stains to existing wood.
Whenever possible, our service professionals will demonstrate stain samples on the actual flooring before the process begins, to give you an accurate impression of what the finished product will look like.
We apply our stains by hand and use machine buffing to ensure uniform coverage.
With glue-down installations, furniture can be moved in and floors can be walked on the next day.
Bleaching is a process commonly used to lighten the color of hardwood floors.
Bleaching is also used prior to a treatment called "pickling," which makes the floor very light in color, but still blond like the natural wood, rather than completely white. This technique is often used as a preparation for "antiquing" and other specialty design effects.
We don't use this process. It's an old technique and out of fashion now. We have better techniques for staining.


text: Zebra Katz - Ima Read feat. Njena Reddd Foxxx (Dj Sliink Remix) by Mad Decent published on 2012-01-19T02:58:40Z Fresh from self releasing his lo-fi mixtape "CHAMPAGNE", ZEBRA KATZ serves you his debut release, Ima Read feat. Njena Reddd Foxxx on Mad Decent's Jeffree's Imprint. Pulling from a multimedia /performance art background, Zebra Katz brings a slo-mo dark delivery to his rhymes set over a the minimal unencumbered beat on "Ima Read".But what does "Ima Read" even mean? Simply put, "reading" is an old voguing term describing someone verbally insulting an opponent about something not so apparent to the average viewer. A good reader could tear you apart with one simply sentence. We were very luck to have such a varied selection remixes from the likes of J-Wow of Buraka Som Sistema, MIkeQ and B.Ames, Slick Shoota and Dj Sliink. A little bit of something for everyone on this one, look out for more from Zebra Katz, he's on the rise. Download via Hulkshare : http://hulkshare.com/i7pdydyrlldr Visit thejeffrees.com to download all past Jeffree releases! Zebra Katz Facebook Twitter Soundcloud Genre Club Comment by Okibi Is there a 320 of this anywhere? 2012/08/23 07:32:15 +0000 Comment by ♕401K♕ playing this every set sliink is the man 2012/03/22 17:34:32 +0000 Comment by franklinpeanut vogue 2012/02/22 00:43:34 +0000 Comment by Matthew James tis good 2012/02/21 14:54:13 +0000 Comment by Cream Dream HOT 2012/02/20 02:58:16 +0000 Comment by sojuju yes cool 2012/01/31 18:55:36 +0000 Comment by DeeJayMoney YA! 2012/01/30 07:07:17 +0000 Comment by Glass Bones <3 2012/01/27 11:57:50 +0000 Comment by Glass Bones noice 2012/01/27 11:57:18 +0000 Comment by Glass Bones I like 2012/01/27 11:57:15 +0000 Comment by Glass Bones delish 2012/01/27 11:57:12 +0000 Comment by ROSEWATER CTZ so good 2012/01/24 20:06:35 +0000 Comment by dj linterna awesome 2012/01/24 00:34:17 +0000 Comment by logwad this one is wicked 2012/01/23 19:49:59 +0000 Comment by Aural_pleasure So your That Bitch? I was wondering who you were. 2012/01/21 18:53:08 +0000 Comment by Dee Esquire PHAT!!! 2012/01/20 22:50:44 +0000 Comment by Ar wen bangin 2012/01/20 16:21:00 +0000 Comment by Lobot's head Big remix !! 2012/01/20 07:15:48 +0000 Comment by DjGETEM Whoa Dere 2012/01/20 05:53:52 +0000 Comment by Gun$ Garcia SOOOOOOO GOOOOOOOOOD!!!!!!!!!!!!!! 2012/01/20 00:39:11 +0000 Comment by Amy Becker huge 2012/01/19 23:08:02 +0000 Comment by ♥Fujiko_Aensland♥ #YAZBITCH! 2012/01/19 22:20:50 +0000 Comment by ♥Fujiko_Aensland♥ #DEATHDROP! OW! I'ma Scantron That Bitch. This Is HoTT! 2012/01/19 22:19:54 +0000 Comment by Jamie What? Sliink wins! Great mix 2012/01/19 22:17:51 +0000 Comment by Divoli S'vere This is FIIYAAHHH!!!!! 2012/01/19 22:13:28 +0000 Comment by djmikeq VOGUE JUST VOGUE BITCH! READDD 2012/01/19 21:25:20 +0000