text:
Admissions Home
2017-2018 Local Student Applications are still OPEN
2017-2018 International Applications are still OPEN - for Semester 2 ONLY
Welcome to Fremont Christian School!
Fremont Christian School welcomes an application from any student who not only desires to be a student at FCS and commits to contributing to a positive campus atmosphere but also has had no suspension or expulsions at a previous school within one calendar year and has earned a minimum grade point average of 2.0 on a 4.0 scale without Fs.
Fremont Christian School is currently accepting applications online for the 2017-2018 school year for Toddler/Preschool through grade 12, and including International students.
A possible start date for a mid-year applicant is considered by the campus principal. FCS will usually allow immediate starts for admitted elementary and junior high school students, but may determine high school student start dates to only be appropriate during the early weeks of a semester. However, special circumstances may be considered such as a family move. Preschool applications are accepted year-round.
How to Apply
The Admissions area of our website is designed to make the application process as simple as possible using our Online Application. We encourage families to apply online as it simplifies submission and provides parents a tool for tracking online the status of their admission after their application has been submitted. To enroll your preschooler after July 1, 2017, please apply online using the 2017-2018 Toddler/Preschool Application.
Creating an Online Application
To begin the Online Application process, select Create an Account from the menu above. Then log into your account, 1 account per family, and provide the information necessary to Create A New Student Application for your child. If you are applying for more than 1 child, you can create a separate application, based on each child's grade level, from within the same family account. You will then have the flexibility to log in and out of your account and access your open application(s).
After submitting the application(s), you will be able to track your admissions status online by logging into your account. From your account, you will be able to print the completed application(s), monitor when the school receives supplemental application forms, and, if necessary, reprint the supplemental forms.
The application deadline for first semester is May 1 for international students requiring an I-20 to obtain an F-1 study visa or sooner if quota is achieved. The deadline to apply for the second semester is November 10.
After you have created an account and are ready to Create A New Student Application, you will be asked to choose the grade level your child is applying for. All international students who require an I-20 to attend school in the USA must select International when choosing a grade level. In another area of the application you will be given the opportunity to tell us what grade the applicant will be entering.
Request More Information
Should you desire more information than is available in online materials, please Request More Information and our Admissions Office will contact you.
We Look Forward to Meeting You
If you have not already done so, please consider making an appointment to visit our school. We would very much like to meet you and take you on a campus tour.
We appreciate your interest, and hope to assist you any way we can. If you have any questions, please feel free to contact us at email@example.com or call 510-744-2241.
* Fremont Christian School has a non-discriminatory racial policy and admits students of any race to all the rights, privileges, programs and activities made available to all regularly enrolled students.


text:
Kelly's Auto Body Centralia
Review for Kelly's Auto Body Centralia
Anayeli S. on 03/04/2014
Anayeli said the business was great. They explained their work and she has not had any issues. So far everything is good.
Category: Collision
Service Date: 02/12/2014
Review Created: 03/04/2014
This review was collected via phone interview by Customer Research Inc.

subset: commoncrawl


text:
Company Background
Asta Funding is a consumer receivable asset management company specializing in the purchase, management and liquidation of performing and non-performing consumer receivables. Asta generates revenue and earnings primarily through the purchase and collection of performing and non-performing consumer receivables that have typically been either charged-off by the credit grantors or not considered to be prime receivables. These receivables include MasterCard (NYSE:MA), Visa (NYSE:V), other credit card accounts issued by banks, telecommunication accounts and other consumer loans issued by credit grantors. Asta may also purchase bulk receivable portfolios that include both distressed and non-conforming loans.
Asta Funding is down 20% since April, trading under $7 for the first time since December of last year. Despite the recent pessimism, the company is moving along just fine and is in a better position than a quarter ago. Basic NCAV (without adjusting for fully-amortized receivables) is up 1.9% to $9.77/share, providing upside of 50% to the current share price. As you can see below, the quality of the assets is increasing as the company's cash position increased by over $10 million to $91.8 million - (click charts to expand).
Q2 Results Review
Revenues increased 0.3% year over year (y/y) to $11.2 million, driven by a 300% increase in other income y/y to $0.1 million. G&A rose 7.1% to $5.65 million. The company's interest expense fell 32% y/y to $0.74 million as the company continues to pay off debt. Diluted EPS fell 3% y/y to 19.2 cents from 19.8 cents.
Fully-Amortized Receivables
The company has significant cash collections from portfolios that are not on the balance sheet. Either the portfolios have been written down or the company has already received the cash in excess of the cost (cost recovery accounting) or projected recoveries from the portfolios (interest method accounting). These receivables are not on the books and provide a source of upside not captured on the balance sheet and my estimate above. In the exhibit below, you can see the quarter by quarter collections from the fully amortized portfolios over the past 4 years.
For the March quarter, this figure came in at $9.1 million, higher than I expected. A company that hasn't been growing its business for a number of years due to poor business conditions usually would have cash flows shrink but Asta has been able to continue generating cash from its fully amortized receivables in excess of its original expectations. After bottoming out at $8 million in the height of the recession in 2009, the company has seen a nice recovery in these cash flows as the economy has turned around.
I originally valued this asset at a very conservative 1x the trailing four quarters fully amortized receivables collections, which as of last quarter was $35 million, however I ignored taxes. I updated this estimate using the finance annuity formula. I estimated that the quarterly decay rate or at what rate this stream of cash flows will decrease is 4%. I based this estimate on the last 4 years of ASFI's fully amortized receivables collections. I assumed the standard 40% tax rate. I used a 10% equity discount rate. I also assumed that this stream of cash flows would last 3 years. I based this number on the disclosure in Asta's filing that stated that the majority of its receivables being accounted for with the interest method are expected to be collected in the next 3 years. The new estimate I came up with is $43.3 million. The detail of the calculation is available below.
Adding this estimate to the original estimate of the assets on the book of $9.77/share, gives Asta a valuation of $12.68/share. In other words, there is upside of nearly 90% to current prices.
The low price of Asta still puzzles me, considering the value in the stock. I think that with no Street coverage and no earnings acceleration, it flies under the radar. The tumultuous few years when the company wrote down a lot of receivables and the unfortunate purchase of a huge portfolio right before the recession are also weighing on sentiment. Regardless, I still believe in the company. With the debt non-recourse and only tied up to receivables, cash sitting at $6.17 a share, the downside here is limited. I will take a bet on any company with this kind of risk-reward.
Disclosure: I am long ASFI.


text: The heavy, finely milled rock (slate) that forms the bed of the table, beneath the cloth . Major slate suppliers for the billiards industry are Italy, Brazil and China. Some cheaper tables, and novelty tables designed for outdoor use, do not use genuine slate beds, but artificial materials such as Slatrol.


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Those who missed the memo that Los Angeles is an amoral swamp achurn with bottom feeders of every stripe will find Jason Freeland's ensemble feature an eye-opener. But it's familiar stuff if you've sampled the vast body of work devoted to LA-dammerung, from Nathaniel West's 1939 Day of the Locust to Robert Altman and Michale Tolkin's THE PLAYER (1992).
The film's literal garden of tainted earthly delights is a hydroponic pot farm, which cheerfully amoral stripper-turned-cutthroat realtor Sally St. Claire (Vinessa Shaw), cultivates. Among those who sample its reality fogging wares are Sally's scummy ex and rival, realtor and amateur porn-magnate Davey (Christopher Allport); homeless cutie-pie Sammy (Erik Scott Smith), an aspiring rocker who blew into town without a dime or a plan; 15-year-old April (Willa Holland), who's fleeing a groping stepfather but doesn't want to live with her dildo-crazy lesbian cousin; generously endowed Nebraska naïf Nathan (Alex Cendese), Sally's sexually confused assistant; gloomy amateur artist Todd (Richard Gunn), who inherited a bundle from his mother and is too obsessed with internet porn – especially old pictures of Sally – to form real relationships; stoner Carlos (Jeff Newman); sleazy photographer Anthony (Patrick Fischler), who sells porn under the clever pseudonym "I.B. Horny;" motor-mouthed wannabe agent Joey Zane (Ross Patterson), who's coasting on his famous father's reputation; and poor little rich girl Becky (Fiona Dourif), who takes a desultory shine to Sammy but can't keep him because her aunt is an uptight bitch.
Everyone photographs or is photographed, because Angel City is all about looks and surface; most sell their bodies and all sell their souls: If they were characters the spectacle of their self degradation might be poignant. But they're just types, so it's hard to care, especially since the lesson of Ricky Nelson's bittersweet song – that self respect counts for more than celebrity – is lost on them.
Cast & Details See all »
- Released: 2008
- Rating: NR
- Review: Those who missed the memo that Los Angeles is an amoral swamp achurn with bottom feeders of every stripe will find Jason Freeland's ensemble feature an eye-opener. But it's familiar stuff if you've sampled the vast body of work devoted to LA-dammerung, fro… (more)
Trending TonightSee all »
Dirk Gently's Holistic Detective Agency9:00 pm | BBCI'll Watch18 Watching
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Ghost Adventures9:00 pm | TRAVELI'll Watch7 Watching
Popular Shows
Popular Movies
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Popular Celebrities
- 1. Rami Malek
- 2. Taylor Schilling
- 3. Constance Zimmer
- 4. Emilia Clarke
- 5. Tom Hiddleston
- 6. Kit Harington
- 7. Gina Rodriguez


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|Home > Music Genre > Action Music > Orchestral Action > Track Summary >
Track Summary
Music Track Title: Building Frenzy
Catalog ID: 538524 ISRC: US5UL1224100
Description: Exciting Epic orchestral and choir track with massive build, fast staccato strings, pounding rhythms & heroic, growling brass. Bold driving powerful & stunning. Stately great for action scenes in fantasy adventure films. Charging into battle. Victory in battle. Cavalry charge. Stampede. Trailer prom
Social Media Link: https://www.audiosparx.com/sa/archive/Action/Hollywood-Orchestral-Action/Building-Frenzy/538524
Artist or Group: Daniel Cullen
Keywords: Opening Bold avengers batman bane marvel power Epic Zimmer Fearless Nature documentaries Climax Intense reality TV shows blockbuster hero triumph superhero
Music Genre > Sub-genre
Action Music
Action Theme | Hollywood orchestral action music (wild and intense)
Extended Properties
Duration: 2:06 Tempo: Medium BPM: 110
Arrangement: Orchestra, Full
Instruments: Contra-bass, Cello, Cymbals, Gong, Strings, Trombone, Trumpet, Tuba, Viola, Violin, Timpani, Brass section, Choir, Field Drum, Bass Drum, Bass Trombone, French Horn, Violoncello
Vocal Mix: Instrumental
Use Restrictions: Use in pornographic, x-rated, sexually stimulating or similar productions prohibited
Moods: Adventurous, Aggressive, Bold, Brave, Building, Climactic, Confrontational, Dangerous, Dark, Driving, Epic, Heroic, Intense, Powerful, Rousing, Stimulating, Tension, Thrilling, Vengeful, Wild
Styles: Action Adventure, Action Thriller, Chase Scene, Cooking Show, Documentary, Dramatic Soundtrack, Fantasy, Film Instrumental, Hollywood, Military, Movie Trailer, Section / Credits, Sports / Extreme
Extended Keywords: fire-eating, gallant, grand, grandiose, gritty, gutsy, gutty, high-flown, impavid, inflated, intrepid, lion-hearted, mythological, noble, stand tall, stouthearted, unafraid, undaunted, valiant, valorous, adventurous, assuming, audacious, aweless, bantam, courageous, daring, dauntless, enterprising, fearless, forward, gallant, heroic, intrepid, resolute, unafraid, undaunted, valiant, sports tv channels, science and nature, blockbuster films, Hollywood, Immediate Music, trailer house track, abc, pbs, itv, BBC, Fox, dragons, soundtrack, filmscore, film score, movie soundtrack, science fiction, science fantasy, epiphany, discovery, national geographic, history channel, klaus Badelt, Alexander Desplat, Remote Control, Dark Knight, James Newton Howard, 12 years a slave, Gladiator, Braveheart, Michael Giacchino, Thomas Newman, Games of Thrones, Battlestar Galactica, Marvel's Agents of Shield, Avatar, Harry Potter


text:
Becks Prime, an upscale fast-casual chain based in Houston, emphasizes the "prime" in its name.
The concept grinds its own certified Angus chuck for burgers on-premise and sears its ahi tuna, and then lets guests relax in the dining room or on outside decks or order at drive-thrus and take their food to go.
The company opened its 13th unit in the Dallas-Fort Worth market in July, and at least three more are planned for that area.
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Contact: Desiree Torres [email protected]


text:
Curiosity was launched to Mars by National Aeronautical Space Administration (NASA) to fulfill the lack of knowledge about Mars Planet. Today also, the Curiosity is finding for many more knowledge, collecting pictures and sending to the Earth. You may be knowing the most latest news of getting more than 1000 liters of water on Mars. This research was done by Curiosity. Now you'll also get to some of its invents.
#1. Mars rover Curiosity finds water in first sample of planet surface
The first scoop of soil analyzed by the analytical suite in the belly of NASA's Curiosity rover reveals that fine materials on the surface of the planet contain several percent water by weight. The results were published on 26th September 2016. Rensselaer Polytechnic Institute Dean of Science Laurie Leshin is the study's lead author.
#2. Curiosity rover finds hints about some changes in the atmosphere of Mars
Learning about to the Mars' atmosphere will assist scientists to know whether the planet ever was habitable. The present atmosphere of Mars is 100 times thinner than Earth's Atmosphere.
Scientists theorize that in Mars' distant past its environment may have been quite different, with persistent water and a thicker atmosphere. NASA's Mars Atmosphere and Volatile Evolution, or MAVEN, mission investigated possible losses from the upper atmosphere when it arrives at Mars in 2014.
#3. No big difference between Rocks of Earth and Mars
When the pictures of Rocks clicked by Curiosity on Mars were sent on the Earth, they were compared with the rocks of Earth. There was just a difference of color between the two types of pebbles. This proves that Mars may have the habitat like Earth many billion years before.
#4. 1000+ liters water found on Mars!
Ample of water was found on Mars flowing steadily in the form of River. It was learnt that the water found on Mars was more than the total amount of water in the city of California! This proves a sign of Life on Mars.
These are the 4 things found yet. These are great events in history and will be the most important matter of concern in future. Do not forget to express your views regarding this post. I hope this wasn't boring. Thank you for taking efforts reading this 🙂


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High Quality AA and AF
Our high quality tests let us separate the men from the boys and the ladies from the girls. If the cards weren't struggling before they will start to now.
Resident Evil 5
HD 5850 - Here we see no real change.
HD 5870 - Here we see no real change.
HD 5970 - Here we see no change at all.
Far Cry 2
HD 5850 - Here we see no real change.
HD 5870 - Here we see no real change.
HD 5970 - Here we see no real change.
PRICING: You can find products similar to this one for sale below.
United States: Find other tech and computer products like this over at Amazon's website.
United Kingdom: Find other tech and computer products like this over at Amazon UK's website.
Canada: Find other tech and computer products like this over at Amazon Canada's website.
- Page 1 [Introduction]
- Page 2 [Test System Setup and 3DMark Vantage]
- Page 3 [Unigine Heaven Benchmark (DX11)]
- Page 4 [Benchmarks - Resident Evil 5]
- Page 5 [Benchmarks - Far Cry 2]
- Page 6 [Benchmarks - Darkest of Days]
- Page 7 [Benchmarks - BattleForge]
- Page 8 [Benchmarks - High Quality AA and AF]
- Page 9 [Final Thoughts]
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- ASUS Republic of Gamers Announces Swift PG27VQ


text:
You must register to post or download hacks.
If you are having any issues, shoot us an email, Contact MPGH Support.
As always, have fun and enjoy your stay!
- MPGH Staff
Requesting my first Usertitle
(In bold if possible)
A Cheetah is the symbol of flexibility, power, speed and elegance.
Previous Names: Leaf, Acinonyx, Fawkes.
Request granted
Leaf (02-22-2011)


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This park is the driest, hottest part of the United States. Located near the Sierra Nevada mountains, it hosts a wide range of geological features such as valleys, canyons, salt flats, sand dunes, and more. Hiking is a popular draw, though it is only permissible outside of the hot summer months. Sights can also be taken in by car or motorcycle. Overnight campers often discover that Death Valley's stargazing is second to none, due to its remote location and dark night skies.
This original SeaWorld location was so popular in its heyday that it went on to open many other parks in many other locations across the country. Tourists have been coming here since 1964 to learn about marine life and ocean ecosystems, and get a sense of the vast and varied types of life that can be found in the world's oceans. They also come to see Shamu, the name of the park's first resident orca and the name under which all the current orcas still perform.
Nestled in between California and Nevada, Lake Tahoe is the largest freshwater lake in the United States after the Great Lakes. The natural beauty of the lake nestled in the pinecovered mountains is aweinspiring. Its high altitude makes it an alpine paradise for skiers, snowmobilers, and other winter outdoor enthusiasts. In the summer months, hiking, biking, and water sports are the main attraction. No matter how you choose to enjoy this mountain paradise, the vistas that surround you will make it a trip to remember.
One of the first things you might notice about this island is its resident herd of American bison. Fourteen animals were brought to the island to film a movie in 1924. Due to budget constraints, the buffalo were left behind once shooting was completed, and now the herd is generally comprised of 150 animals. Visitors to Santa Catalina Island can enjoy a glass bottom tour boat that takes them around the shipwrecks and coral reefs that lie offshore. Parasailing and surfing are also popular choices
You cannot understand the magnitude of a redwood until you see it. Trees that stand wide enough to be carved out in the middle to let cars drive through are a common occurrence. Highway 101 runs through a large portion of the park, close to the coast. Motels and attractions dating back to the dawn of American automobile tourism can still be found, like Trees of Mystery featuring a giant statue of Paul Bunyan and his blue ox, Babe. The theme parks pale in comparison to the stately elegance of the surrounding forests, the natural beauty of which needs no augmentation.


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If you are anything like me, you are probably so over the winter blues. Banish winter blahs and brighten up your home indoors and out with some fresh flowers, cheery spring colors and whimsical Easter-themed touches. Let's dive into the brightness together!
Bulbs in Chalkboard Pots
Why not add a cheery pop of spring color to your foyer, living room, kitchen or bedroom? Get a chalkboard spray paint and some super versatile and inexpensive terra cotta pots and start getting creative! Add a tulip bulb and once it has finished blooming indoors, plant it outside and enjoy it for many springs to come!
Wreath Away…
Add some life to your super boring wreath 🙂 Use plants that represent spring and are easy to care for, such as succulents and moss. In other words, get moss-y with it!
Get Your Glitter On
Shimmering eggs in a bed of moss make a lovely (and easy!) Easter centerpiece. To create them, paint wooden, cardboard or blown-out eggs in soft pastel shades. Once the paint has dried, apply glue dots in a random pattern then sprinkle glitter over the eggs for a sparkling polka dot effect. Adorbs!
Bring the Indoors Out
My ultimate favorite! Why stay cooped up inside when dining outdoors in the spring is such a treat we often take for granted! Carry the dining table outside and enjoy your Easter dinner in the sunshine surrounded by trees, bushes and flowers just breaking into bloom. Keep it simple, fresh,clean and bright!
Pretty Place Settings
Seriously, how sweet are these little chicks? Why not creatively show your guests their seat? Simply print your guests' names onto small strips of card stock then top each plate with a pair of fluffy chicks and candy eggs. Chick-a-lish!
Old Vase Go Away!
Do yourself a favor before going to spend more money at the craft store! Take your old ordinary vases or jars and wrap them with spring-inspired wrapping paper. Mix and match patterns and fill vases with bold flowers to create an eye-catching centerpiece! Cheap, almost free and gorgeous! What's not to love?
Eggs in the Carton
Create an appealing, low centerpiece using eggs, flowers and an egg carton. To make this, pierce the top of a raw egg with a pin, then gently poke the hole with your finger to widen it. Empty the whites and yolk carefully through the hole, and rinse the shell with water. Fill with delicate flowers like sweet pea and mimosa. Place the eggs in a carton or individually in eggcups. Cuteness doesn't begin to describe this creative little piece!
Faux Bird's Nest With Robin's Eggs
In under an hour, you can turn aluminum foil (yes, aluminum foil), Spanish moss, tree bark and sphagnum moss into a realistic bird's nest you can fill with painted robin's eggs or Easter treats. Ummm…sign me up!
Drama Time
Tall manzanita branches hung with paper butterflies create an architectural centerpiece for this sun-washed spring table setting by thrify diva Kate Riley. Vintage plates, pale blue dyed eggs and fluffy white hydrangeas work together to create an icy, eye-catching color palette. I heart it!
Gift Away
Use leftover moss from your centerpiece to make party favors for family and friends. Fill miniature baskets with moss and speckled candy eggs and attach a name tag with each guest's name on each basket. The baskets serve double duty as favors and place cards. We heart it and hope that you do too!
Whatever you choose, make sure to enjoy the holiday with your loved ones! Be happy, smile and keep it bright 🙂


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Post-ABC poll: Immigration, border and a path to citizenship
Q: Do you support or oppose a path to citizenship for illegal immigrants?
Show results by:
Show results by:
The Washington Post - ABC News poll
Question 1 of 3
In this poll:
Click "detailed view" to see interactive results by political and demographic groups (i.e. Democrats, ages 18-39).
This poll was conducted for The Washington Post and ABC News by telephone January 30 to February 3, 2013 among a random national sample of 1,038 adults, including users of both conventional and cellular phones. The results from the full survey have a margin of sampling error of plus or minus 3.5 percentage points. Sampling, data collection and tabulation by SSRS of Media, Pa. Produced for the Washington Post by Capital Insight.


text:
Johnson Supply, Services, listed under "Services" category, is located at 1510 Studemont St Houston TX, 77007 and can be reached by 7138693700 phone number. Johnson Supply has currently 0 reviews.This business profile is not yet claimed, and if you are the owner, claim your business profile for free. If you are not the owner you can invite this business to join by email or by phone.Browse all Services in Houston TX. Discover census data for Houston, TX.
Back to Top


text:
Status: By Appointment
Know more about this business than we do? Cool! Please submit any corrections or missing details you may have.Help us make it right
255350attr:wine tastings
Be the first OregonLive.com user to add photos or videos of Cameron Winery
Cameron Winery is located at 8200 Ne Worden Hill Rd, Dundee, OR. This business specializes in Wineries.


text:
House Republicans have crunched the numbers and say that since President Obama took office, the economy has added seven times more part-time jobs than it has created full-time jobs.
Since January 2009 the country has added a net total of 270,000 full-time jobs, but it has added 1.9 million part-time jobs, according to the House Ways and Means Committee.
Read full article: Nearly 90% of New Jobs Since 2009 Are Part-Time


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Room Sizes and Capacities
The Sinclair Conference Center staff will be happy to help you select the best rooms and service options to meet your needs and fit within your budget. Planning your meeting is even easier with our Complete Meeting Packages (CMPs) which provide all your meeting components, such as: rooms, meals, refreshment breaks, multimedia technology, parking and service charges. Our CMPs are designed to simplify your planning and budgeting process while saving you time and money. Our staff will be happy to provide you with more information about our CMP options.


text:
MAYOR Peter Davies says he wants no more lap dancing clubs in Doncaster, after backing regulations which will govern where they are allowed to operate.
New rules approved by Doncaster Council's cabinet effectively ban the clubs from a range of areas which are deemed to be sensitive.
It means the council will not grant operating licences which would be required under the new rules at sites including near schools, parks, recreation areas and churches.
Mr Davies said: "I would rather not have had any of these establishments in Doncaster. But I am told the two we do have are not open on a regular basis."
Doncaster has two sites were lap dancing takes place - Bentleys, in Hall Gate, and Players in Cleveland Street.


text:
Steve Chiotakis: Yeah, we know some businesses have done a good bit of cutting in this recession -- cutting of fees. Law firms, ad agencies, even therapists are doing it. But there seems to be another side to all this discounting. Those who are doing the discounting say their clients are getting a wee-bit out of line.
Ashley Milne-Tyte reports.
Ashley Milne-Tyte: Everyone's negotiating fees these days. But Marc Brownstein of marketing agency the Brownstein Group says negotiating is one thing, demanding is another. He recently heard from a lawyer friend:
Marc Brownstein: He said that clients have been dictating fees to them. So if a lawyer has a certain billable hour, the client is saying "no, this is what we're going to pay for this service."
He says marketing firms have also experienced a sudden rash of what he calls bad behavior from clients: e-mails have a cranky tone, some clients don't pay invoices until they're chased. Some even want firms to break ethical boundaries. Brownstein says one client wanted his agency to fudge some numbers.
Brownstein: It seems that this recession, the longer it goes, is unveiling the dark side of perfectly civilized and likeable professionals.
Brownstein says his company refused, of course. He understands companies are under enormous pressure to conserve cash. But he says being antagonistic or pushy can gnaw away at relationships that took a lot of time, effort and money to build.
I'm Ashley Milne-Tyte for Marketplace.


text:
An ultrasound is an imaging test that uses sound waves to see what may be happening inside your body. It is sometimes called a sonogram.
Ultrasound is used to look for disease or dysfunction in the body's internal organs and tissues. During the test, the doctor or technician may:
An ultrasound is usually painless and does not use ionizing radiation like an x-ray. Instead, a device called a transducer is moved over the part of your body that needs to be examined. A slippery gel is used on the skin to help the transducer move easily over the area. The transducer sends soundwaves into your body. The soundwaves bounce off of your organs, tissues, and fluids and are sent back to the transducer. The transducer sends that information to a computer that creates pictures of the area being studied.
In most cases, you don't need to do anything special to prepare for an ultrasound. However, your doctor may give you specific instructions about eating and drinking or going to the bathroom in the hours before the procedure. Wear loose, comfortable clothing to the exam. You may be asked to wear a gown.
After the test, the pictures and information from your test are read by a radiologist – a doctor who is specially trained to read ultrasound images. The radiologist will tell your doctor what, if anything, may be of concern.
It might take from one to three days to get your test results. Your doctor or nurse will usually call you with the results, or discuss them with you during a follow-up appointment.
Visit the "Imaging" section of the Intermountain "Clinical Research" page.
For more information on ultrasound, visit:
© Copyright 2017 Intermountain Healthcare. All rights reserved.
This medical information is provided by Intermountain Healthcare. It has not been developed to replace medical advice provided by your health care provider.
Last review date: March 2017
Get Care Now
Get care for low-level urgent conditions through a video chat with a provider, 24/7, on your computer or mobile device.Learn More.
View wait times and save your place in line at an Intermountain InstaCare location near you.
If this is an emergency please go to the nearest emergency room or call 911.
Intermountain Healthcare is a Utah-based, not-for-profit system of 22 hospitals, a Medical Group with more than 1,600 physicians and advanced practice clinicians at about 180 clinics, a health plans division called SelectHealth, and other health services. Helping people live the healthiest lives possible, Intermountain is widely recognized as a leader in clinical quality improvement and in efficient healthcare delivery.
Still not finding what you are looking for?
Copyright ©2017, Intermountain Healthcare, All rights reserved.


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Sting has no Love for Beyonce
Many people are loving Beyonce's new album, but there is one very famous artist who is not a fan. Sting is totally bashing Beyonce and Justin for making music that is too commercial. He says that artists should be driven by spiritual experiences, not record sales. Here's more:
"Today's music is not designed for me. I don't understand a Beyonce or Justin Timberlake. For me, singing is a spiritual journey. I'm devoutly musical. As for my voice, I'd say it's become more mature. Encrypted with life, it's developed texture. This particular album I made in our home in Tuscany. I don't work in any thematically soundproofed room. I like ambient noises - fire crackling, birds singing, church bells. It's organic."
Funny Sting should pick Beyonce and JT out of the crowd. These are two artists who are trying to sound different these days and the result has been killer record sales. Check out Beyonce at the Armani show for London Fashion Week. Lots more pics so


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Hills Prescription Diet Dog cd Urinary Tract Health 12kg
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Traumatic experiences in early childhood are associated with increased risk for developing mood and anxiety disorders later in life. Low serotonin1A receptor (5-HT1AR) density during development has been proposed as a trait-like characteristic leading to increased vulnerability of stress-related neuropsychiatric disorders.
To assess the relationship between early-life stress and alterations in the serotonin system during development, we used positron emission tomography (PET) to measure in vivo 5-HT1AR density and apparent dissociation constant (KDapp) in the brain of juvenile rhesus monkeys exposed to the early-life stress of peer-rearing.
In general, 5-HT1AR density and KDapp were decreased in peer-reared compared with control mother-reared animals. However, increase in receptor density was found in the dorsomedial prefrontal cortex of peer-reared females.
These findings suggest that exposure to an adverse early-life environment during infancy is associated with long-term alterations in the serotonin system and, support previous studies suggesting that reduced 5-HT1AR density during development may be a factor increasing vulnerability to stress-related neuropsychiatric disorders. Further, alterations in the serotonin system appeared to be gender- and region-specific, providing a biological basis for the higher prevalence of affective disorders in women.
Low 5-HT1AR binding, measured by PET and in vitro binding assays of postmortem brain tissue, is found in individuals with several anxiety-related disorders, including depression, social anxiety and panic disorders (1–8). Moreover, a spontaneous variation in the HTR1A gene promoter that results in lower levels of HTR1A expression (9) is also associated with anxiety-related personality traits (10).
Rodent studies have demonstrated that 5-HT1AR knockout −/− and −/+ heterozygous mice demonstrate high levels of anxiety-like behaviors, while mice over expressing this receptor show reduced anxiety levels (11). Importantly, Gross and colleagues reported that the expression of 5-HT1ARs early during development, but not in adulthood, is critical to rescue the anxiety-related phenotype in knockout −/− mice (12). The above evidence from human and animal studies has lead to the proposal that low 5-HT1AR density early in life may increase vulnerability for anxiety-related disorders (11, 13).
Epidemiological data indicate a higher prevalence of mood and anxiety disorders in women compared to men, with these gender differences appearing first during puberty (14, 15), suggesting that, in light of the above evidence, lower 5-HT1AR density might be expected in women. However, previous studies reported either increased 5-HT1AR availability in women (16, 17), or no gender differences (18). In addition, higher 5-HT1AR availability measured by PET (19, 20) and increased 5-HT1ARs in vitro binding (1) has also been reported in depressed patients.
These results seem in contrast with the hypothesis that low 5-HT1AR density increases vulnerability for affective disorders. However, at least three factors need to be considered when interpreting these data. First, the reported studies were all performed in adults, while low 5-HT1AR expression during development, not in the adulthood, is hypothesized to be a critical risk factor for anxiety-related disorders (12). Second, the primary outcome of PET studies is receptor availability, measured by binding potential. Although receptor availability is directly proportional to receptor density, it also reflects competition at the binding sites between the endogenous neurotransmitter and PET radioligand. This competition can be influenced by several factors, including variations in endogenous synaptic 5-HT levels, receptor internalization and/or changes in receptor affinity for 5-HT, all of which would affect receptor occupancy, and consequently, receptor availability for the exogenous PET radioligand. Finally, in vitro binding studies in humans are often conducted in post mortem tissue from suicide victims, which may not be representative of generalized affective disorders in the population or the in vivo characteristics of the receptor.
Among environmental factors, traumatic experiences during childhood are consistently linked to an increased risk for developing anxiety-related neuropsychiatric diseases (21). For example, early loss of a parent leads to increased risk for anxiety, depression, and abnormalities of the hypothalamic-pituitary-adrenal (HPA) axis (22, 23). In this respect, rhesus macaques deprived of their parents during infancy provide a particularly germane animal model to investigate the long-term consequences of early-life adversity on 5-HT1AR expression. Previous studies show that peer-reared (PR) monkeys exhibit dysfunctions of the 5-HT system, HPA axis, and high levels of anxiety-like behaviors compared to animals reared with their mothers (MR) (24–26). We employed this model to study the long-term effects of early-life stress on 5-HT1AR availability using PET and [18F]FPWAY, an analogue of WAY100636 and a selective 5-HT1AR antagonist (27, 28).
By definition, receptor availability is proportional to total receptor density (Bmax) and radioligand affinity for the receptor (1/KDapp, where KDapp is the apparent dissociation constant). We employed an experimental design that allowed us to calculate Bmax and KDapp of [18F]FPWAY to determine the contribution of each parameter to potential receptor availability alterations. Importantly, KDapp represents the dissociation constant of radioligand (KD) adjusted for occupancy by the endogenous neurotransmitter (29). We hypothesized that juvenile PR monkeys would show decreased 5-HT1AR density and availability compared to MR monkeys and that the effect would be more pronounced in females.
Protocols for the care and use of experimental animals were approved by the Institutional Animal Care and Use Committee of the National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse (NIDA) and National Institute of Child Health and Human Development, National Institutes of Health (NIH).
Twenty-one rhesus macaques (Macaca mulatta), representing 2 birth cohorts, were born and housed at the NIH Animal Center in Poolesville, MD. At birth, subjects were randomly assigned into two groups with different social and rearing experiences. MR monkeys (n=11; 6 males) were reared for the first 6 months of life with their biological or adopted mothers and fathers in social groups comprised of 8 to 12 adult females (about half of whom had same-aged infants) and 2 adult males.
PR monkeys (n=10; 5 males) were separated from their mothers and housed in an incubator for the first 14 days of life. From day 14 to 37, they were placed alone in a nursery cage and provided a blanket and a terry cloth–covered, rocking surrogate. At day 37, they were placed in a cage with 3 other age-mates with whom they thereafter had continuous access. At 6 months of age, MR subjects were removed from their mother and social group and housed together with the PR monkeys. Thereafter, both groups received identical treatment (26).
The study was conducted when the monkeys were about 24 months old (Table 1), corresponding to childhood in terms of human brain development (6–8 years old) (30). The animals were transported in groups of four to the NIDA-IRP in Baltimore, where they were housed in pairs for about one month, during which time the study was performed. One week before their transport, cerebrospinal fluid (CSF) was collected and assayed for baseline levels of the 5-HT metabolite 5-hydroxyindoleacetic acid (5-HIAA) [(26) and Supplemental Methods and Materials in Supplement 1].
[18F]FPWAY was produced as described (31). There were no differences in the specific activity across groups [males: 1521.2 ± 341.4, females: 2014.8 ± 331.9 (p>0.3); MR: 1454.5 ± 206.9, PR: 2081.5 ± 419.0 (p>0.2)].
PET data were acquired on a Siemens Exact ECAT HR+ whole body tomograph (63 slices, center to center spacing of 2.4mm, with an in-plane resolution, full width at half maximum (FWHM), of 4.7mm at the center of the field of view and axial spatial resolution (or slice thickness) of 4.2mm in 3D mode. Before each radioligand administration, transmission scans were acquired with three rotating 68Ge-68Ga sources. Transmission scans were used to correct the emission scans for the attenuation of 511keV photons by body tissue and face mask. PET images were reconstructed from the raw data with a standard filtered back-projection algorithm and a RAMP filter.
Each monkey was anesthetized with 1.5mg/kg alfadolone and alfaxolone acetate (Saffan®, Arnolds Veterinary Products, Shropshire, U.K.), given intramuscularly. The monkey was intubated, an arterial line inserted for subsequent blood sampling and an intravenous line was set for the continuous intravenous infusion of 9–14mg/kg/h Saffan® to allow transport of the animal from the Animal Facility to the PET Center. Anesthesia was subsequently maintained throughout the PET study by 1.5–2.0% isoflurane.
An individually molded thermoplastic face mask was secured to a custom-made monkey head-holder attached to a backboard. The monkey's head was positioned in the gantry with the aid of orthogonal laser lines. [18F]FPWAY, 6–18mCi, was administered intravenously as a bolus followed by a constant infusion (B/I) to reach an equilibrium state of radioactivity distribution. The bolus component delivered a volume of radiotracer equivalent to the volume that would be administered in the subsequent 60min infusion period (Kbol=60min). Acquisition of dynamic PET scans started with the beginning of the bolus component administration and continued for 180–210min. At 120min after the bolus infusion, an unlabelled FPWAY injection started as B/I (Kbol=40min) corresponding to the equilibrium infusion rate of 0.15nmol/kg/min. Specific activity in the second period was calculated by the ratio of the radioactivity infusion rate to the mass infusion rate. Blood samples were drawn at predetermined times from the arterial catheter with the first sample before dosing and subsequent samples following attainment of equilibrium (70 to 210min); plasma radioactivity and concentration of non-metabolized [18F]FPWAY not bound to plasma proteins were measured (32). Vital signs, including heart rate, EKG, respiration rate, end tidal CO2 and blood oxygen saturation (maintained above 95%) were continuously monitored during the study.
Structural brain images were acquired on a 3.0 Tesla Siemens Magnetom Allegra MRI (Siemens Medical Solutions, Inc., Malvern, PA, U.S.A.). MRI and PET acquisitions were separated by at least 2 days to allow full recovery between studies [(34) and Supplement 1].
A ROI analysis was performed on brain regions previously implicated in emotional regulation and stress reactivity (21, 33) and known to be vulnerable to stress exposure (21, 34): amygdala (AMY), hippocampus (HC), dorsomedial prefrontal cortex (dmPFC) and anterior and medial cingulate cortex (ACC and MCC). We also included the midbrain raphe nuclei (RN), an area where 5-HT1ARs are present in high density and are organized as somatodendritic autoreceptors that help regulate 5-HT neurotransmission in other brain regions (35). ROIs were drawn on the T1-weighted MRI images of each monkey with reference to a stereotaxic atlas (36) (in Supplement 1, see Methods and Materials and Figure S1), and were co-registered to the PET images. For co-registration, MRI images of each monkey were re-sliced to the PET voxel size (1.14mm × 1.14mm × 2.45mm) and averaged between 90 and 120min after the start of [18F]FPWAY administration. PET images were manually aligned to their corresponding T1 MRI images (Fig. 1) using Fusion mode in PMOD v.2.7, (PMOD Technologies Ltd., Zurich, Switzerland). The obtained transformation parameters were applied to the respective re-sliced dynamic PET images. Time–activity curves were calculated based on the mean radioactivity (kBq/ml) for each ROI (Fig. 2a).
Binding potential (BP) was calculated as BPND and BPF defined by consensus nomenclature for in vivo imaging of reversible radioligand binding (37). Here we report BPND calculated as the ratio of specifically bound radioligand concentration to that of non-displaceable radioligand concentration in tissue ((CROI − CND)/CND) at equilibrium (BPND = (CROI − CND)/CND = fNDBmax/KDapp) [results for BPF were similar and given in Supplement 1].
The 5-HT1AR Bmax and the KDapp of [18F]FPWAY in each brain region were calculated using Scatchard analysis (29). KDapp is defined as the in vivo KD adjusted for occupancy by 5-HT and by [18F]FPWAY non-displaceable fraction in tissue. After equilibrium was reached (first point: 90 to 120min after the start of [18F]FPWAY injection; second point 50 to 90min after the beginning of unlabelled [18F]FPWAY administration (Fig. 2b), specifically bound radioactivity was calculated as the difference between the total radioactivity measured in a brain ROI (CROI) and that in the cerebellum (CCB). (CROI − CCB) was plotted against (CROI − CCB)/ CCB. Due to technical problems, data acquisition for one male MR monkey was stopped after 120min and thus Bmax and KDapp could not be calculated for this animal.
StatView 5.0.1 (SAS Institute, Inc., Cary, NC) was used for all statistical analyses. When ROIs were considered as a group, a multivariate analysis of variance (MANOVA) was conducted to assess the overall effects of rearing condition on Bmax, KDapp and BPND. Analyses were performed on the natural logarithm of the data to achieve homogeneity of variances, after adding 2.5 to all measures to ensure positivity. However, Tables and Figures report actual, not log-transformed values. A two-way analysis of variance (ANOVA) was conducted with rearing condition (MR or PR) and sex (male or female) as independent variables for BPND data in each ROI, as well as physiological measures. Significance was set at p<0.05 two-tailed alternatives, not adjusted for multiple comparisons.
ANOVA showed no difference in age across rearing group (F(1,17)=1.70, p>0.20) or sex (F(1,17)=0.34, p>0.33), as well as no difference in body weight across rearing conditions (F(1,17)=2.63, p>0.74). However, as expected, females had lower body weight than males (F(1,17)=12.62, p<0.003). CSF 5-HIAA concentrations were lower in PR animals (F(1,12)=5.23, p<0.05), but there was no difference between sexes (F(1,12)=1.42, p>0.26; Table 1).
Generally, the pattern of BPND values (Table 4) across studied brain areas within each of the four groups was similar to that previously reported in human PET experiments (18) and followed the pattern of 5-HT1AR brain distribution observed using in vitro binding assay of postmortem human brain tissue (38). BPND and Bmax values varied across studied brain areas. The HC and MCC showed the highest 5-HT1AR density and BPND values under both rearing conditions followed by MCC, ACC, AMY and DmPFC, respectively. The lowest BPND and Bmax values were determined in RN (Fig. 3, Table 2 and and44).
The AMY showed the highest KDapp values for both rearing conditions followed by HC (Table 3, but see PR males). Compared to the AMY, KDapp values were 30–50% lower in the other regions (MCC, ACC, dmPFC, RN), which also showed limited variability (2–12%) across brain areas within each experimental group.
For the 10 MR and 10 PR juvenile monkeys analyzed ([18F]FPWAY specific activity was not available for one MR male monkey), a MANOVA for Bmax values across all ROIs revealed a trend for lower 5-HT1AR density (F(6,11)=2.60, p>0.08, Table 2) and significantly lower KDapp values (F(6,11)=4.27, p<0.02, Table 3) in PR animals. There was no effect of sex on Bmax or KDapp (F(6,11)=0.99, p>0.47 and F(6,11)=0.93, p>0.51, respectively) nor was there a rearing × sex interaction (F(6,11)=0.55, p>0.76 and F(6,11)=0.91, p>0.52 for Bmax and KDapp , respectively).
Similarly, MANOVA for KDapp across all ROIs revealed lower values in PR animals (F(6,11)=4.27, p<0.02, Table 3). Again, there was no effect of sex (F(6,11)=0.93, p>0.51) or rearing × sex interaction (F(6,11)=0.91, p>0.52). Two-way ANOVAs on each ROI revealed a significant rearing effect in the HC (F(1,16)=4.80, p<0.05); no sex (F(1,16)=1.20, p>0.28) or rearing × sex interaction (F(1,16)=0.32, p<0.57) effects were found. There was no significant correlation between mean KDapp (or Bmax values in any brain ROI) and 5-HIAA concentrations.
Peer-rearing affected BPND values in several brain regions as demonstrated by MANOVA (F(6,12)=5.74, p<0.006), in the absence of a main effect of sex (F(6,12)=0.38, p>0.87) or a rearing × sex interaction (F(6,12)=1.63, p>0.22). Two-way ANOVAs on each ROI revealed a significant rearing effect in the dmPFC (F(1,17)=6.79, p<0.02) but no sex effect (F(1,17)=0.97, p>0.33). There was a significant rearing × sex interaction in the following three brain regions: dmPFC (F(1,17)=6.81, p<0.02), MCC (F(1,17)=4.79, p<0.05) and ACC (F(1,17)=5.88, p<0.03), but no main effect of rearing or sex [MCC rearing (F(1,17)=0.96, p>0.34), sex (F(1,17)=0.49, p>0.49); ACC rearing (F(1,17)=0.32, p>0.58), sex (F(1,17)=0.18, p>0.68)]. Because of the rearing × sex interaction, we conducted an unpaired t-test for each sex separately.
In PR females, BPND values were greater in the dmPFC compared to control females (t(1,8)=−3.73, p<0.006; Table 4 and Fig. 3), while in males there was no significant effect of rearing condition in this area (t(1,9)=0.00, p>0.99). However in males, peer-rearing induced a significant reduction in BPND values in the MCC (t(1,9)=2.66, p<0.03) and the ACC (t(1,9)=2.55, p<0.04; Table 4 and Fig. 3), with no significant effect in female monkeys in either of these areas (t(1,8)=−0.74, p>0.48 and t(1,8)= −1.12, p>0.29, respectively). There was no significant correlation between 5-HIAA concentration and BPND.
The present study shows that early-life stress as a result of parental deprivation affects 5-HT1ARs density and radioligand affinity. In both males and females, peer-rearing induced an overall decrease in Bmax and in KDapp. The exception was the dmPFC in females, where Bmax values were elevated. Our results are consistent with the hypothesis that exposure to an adverse environment during infancy has long-term consequences on the 5-HT system. To our knowledge, these findings provide the first evidence in nonhuman primates for such developmental changes in an aspect of the 5-HT system that has been strongly linked to anxiety and depression.
Overall our findings in nonhuman primates are consistent with and extend the data from human PET and in vitro binding studies of post mortem brain tissue suggesting a down-regulation of 5-HT1ARs associated with anxiety disorders (39, 40). The present results are also consistent with previous evidence indicating decreased 5-HT1AR availability using PET in adult females macaques with signs of behavioral "depression"(41), and decreased 5-HT1AR binding and mRNA expression in vitro in the HC in marmoset monkeys exposed to early-life stress (42). Moreover, low 5-HT1AR binding in the HC and ACC was found in male rats exposed to early-life stress (43).
Surprising, early-life stress was associated with increased 5-HT1AR density the in the dmPFC in female monkeys. Using structural MRI in the same cohort of monkeys, we recently reported (34) increased volume of the dmPFC and cingulate cortex in male and female PR animals. As such, it is possible that partial volume effect contributed to the present result. However, lower Bmax values in females PR monkeys were found in the ACC, a region that also showed increased gray matter volume in PR animals, suggesting that any structural changes in the dmPFC may not fully account for the present Bmax differences. Gender differences in PFC 5-HT1AR density have been observed in humans using in vitro binding assays from postmortem brain tissue (44). Moreover, specific changes in 5-HT1AR protein levels were found in PFC of depressed female patients (45). As a part of the 'medial prefrontal network', the dmPFC, together with the cingulate cortex, is thought to modulate activity in limbic structures (e.g. AMY and HC) known to be important for the processing of emotional information (46, 47). Taken together, these data suggest that gender differences in brain regions involved in the cognitive control of emotional regulation are present on a molecular level, and may contribute to the increased vulnerability to affective disorders in women.
In addition to the tendency for an overall decrease in Bmax values, we also found an increased radioligand affinity for 5-HT1AR in PR animals, as shown by the decreased KDapp values, particularly in the HC. Reduced KDapp values reflect less competition between radioligand and endogenous 5-HT at the receptor sites, which could be related to one or more of the following: lower baseline 5-HT levels, reduced 5-HT affinity for 5-HT1AR as a result of conformational receptor alterations, or such other factors as receptor internalization (48). Unfortunately, PET analysis limitations do not allow us to define the exact reason for the observed changes in radioligand affinity. Nevertheless, the decreased CSF 5-HIAA concentrations found in PR animals in the present study, and throughout development by earlier findings (24, 26), support the hypothesis of lower brain 5-HT levels in PR animals. However, since neither KDapp nor CSF 5-HIAA concentrations represent direct measures of 5-HT levels in the brain, future investigations using other techniques, such as microdialysis, are warranted to confirm that early-life stress affects endogenous 5-HT in PR animals. In rodents, early-life stress has been shown to affect both basal 5-HT and 5-HIAA levels in several brain regions (49), and previous data obtained by in vitro assays in rodents exposed to chronic stress showed decreased 5-HT1AR density and increased 5-HT1AR affinity in the HC (50), indicating that stress might induce transcriptional or post-transcriptional effects on 5-HT1AR in this region.
Our results on 5-HT1AR availability calculated as BPND (and BPF, see Supplement 1) indicate that the effect of peer-rearing on BPND was different in males and females. Bmax values were decreased in most brain regions in male and female PR animals. However, while overall lower 5-HT1AR availability was found in PR males, it was increased in PR females compared to control MR animals. These gender differences in receptor availability may be related to reported differences in SSRI efficacy between men and women (51). As mentioned in the Introduction, differences in 5-HT1AR availability can be linked to changes in receptor density, radioligand apparent affinity (1/KDapp) or both as demonstrated in the current study. Our results further emphasize the importance of considering changes in receptor availability along with concomitant changes in 5-HT1AR density and in vivo affinity.
Overall these data suggest that early-life stress is associated with changes in the development of the 5-HT system in brain regions considered to be critically involved in major depression and to be modulated by antidepressant treatment (47). An impaired interaction between neural networks involved in emotional and cognitive processing is proposed as a key dysfunction in mood disorders (46, 47). Specifically, it is suggested that the dmPFC, dorsal ACC and posterior cingulate cortex are part of a "dorsal network" involved in emotional and cognitive deficits, while the HC and the AMY are part of a "ventral network" associated with vegetative and somatic symptoms of mood disorders; the (rostral) ACC, which is connected to both networks, is thought to have a more regulatory function (46). Moreover, antidepressant treatment, known to increase 5-HT levels, is known to modulate neural activity in these regions/networks (52).
In this context, our data indicate that peer-rearing stress affects 5-HT1AR density and in vivo affinity in brain regions known to play a key role in affective disorders. Affinity changes, particularly in the HC, may be important considering that the SSRI efficacy seems to be mediated by 5-HT1AR and by neurogenesis in the HC (53). It is also possible that region- and sex-specific changes in 5-HT1AR function during development have important consequences on cognitive abilities (54). The 5-HT system is implicated in the behavioral and brain responsiveness to punishment (55). Modulation of the 5-HT system has been shown to affect neural activity in dmPFC during negative feedback processing in humans (56) and a disrupted top-down control by dmPFC over AMY has been proposed to underlie some of the negative feedback deficits reported in depression (57). Recently, increased responding to threat (and reward) has been reported specifically in two-year old PR males (58), supporting the hypothesis that 5-HT changes may affect the processing of negative information. However, it is unclear if and how 5-HT1AR alterations during development may be related to cognitive differences in humans and potentially to increased vulnerability for affective disorders later in life.
We found no differences in Bmax values between male and female monkeys in either the MR or PR group. Although the number of subjects (n=21) was relatively high for a nonhuman primate study, it may still not have been sufficient to demonstrate more subtle differences between males and females. Previous PET studies in humans showed either no changes or elevated 5-HT1AR availability in healthy adult women (16–18). Conversely, there are as yet no data regarding the levels of brain 5-HT1AR in children, which due to issues of radioactivity administration, are not likely to be easily obtained. Gender differences in 5-HT1AR in the adult nonhuman primate brain is also not available at this point in time. However, since in vitro data from rodents show sex differences in 5-HT1AR binding both in adults and throughout development (59, 60), it is possible that sex specific differences are also present during development in nonhuman primates. Thus, future in vitro binding and microdialysis studies will be important to confirm our PET results and to investigate possible sex differences in 5-HT1AR density and 5-HT levels occurring during development.
In conclusion, we provide the first evidence in nonhuman primates that a model of early-life stress affects 5-HT1AR density and in vivo affinity in juvenile monkeys. Specifically, we found decreased 5-HT1AR density and KDapp in PR animals. However, in females, early-life stress induced an increase in 5-HT1AR density in the dmPFC, a brain region involved in emotional regulation. Overall these findings support the hypothesis that low 5-HT1AR density during development may be related to an increased risk for affective disorders. Moreover, sex difference may be present early in development and need to be considered in the context of the increased vulnerability for mood and anxiety disorders reported in women.
The authors thank Karen McCullough and Larry Reyes for providing excellent technical assistance, Eric Singley, Stephen Lindell, and Melanie Schwandt for physiological data collection and analyses and Eliscia Smith, Varughese Kurian and Ira Baum for assisting during MR and PET scanning. We gratefully acknowledge Carlo Contoreggi for financial support and early conversations during the study inception. Drs Carson, Jagoda, Lang and Stein were involved in designing and conducting the PET study. Drs Higley, Suomi, and Barr oversaw the rearing of the monkeys and the collection of physiological data. Dr Heilig oversaw the analyses of physiological data.
This work was supported by the Intramural Research Programs of the National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse, National Institute of Child Health and Human Development and the National Institute of Biomedical Imaging and Bioengineering.
Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Conflict of Interest
The authors report no biomedical financial interests or potential conflicts of interest.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text:
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Paloma P.
Toronto, Canada, M5S...
Joined on January, 2013
Gender: Female
Average Rating:
Any day after 10AM
Lives Near:
Can Meet:
Up to 30 minutes away for a flat fee
EducationAs a straight A student myself, I love helping my clients go from C's to A's. I have an MA and honors B.A. in English from the University of Toronto, graduating with High Distinctions. I was accepted to a very competitive Masters program at the University of Toronto (the Masters of Creative Writing in the Field of English) that accepts only 7 students in Canada each year. In the second year of the program, we write a book. Throughout my time as a student at the University of Toronto, I have won numerous scholarships and awards for my writing, including the Avie Bennett Scholarship, the Woodhouse Scholarship in English twice, and the Norma Epstein Award for Creative Writing twice. I have made the Dean's List each year since entering university. I recently completed an editing course at Innis College.
I have been editing for years. I am very confident in my ability to revise texts, polishing essays so that they are clear, persuasive and powerful. My clients often email or text me to let me know that they have been accepted to the grad school of their choice or have received an A on the texts we have worked on and revised. It is my goal to see my students reach and surpass their own goals for myself and I am happy to say that I am often rewarded by seeing them improve and thrive! I also tutor students for whom English is a second language and provide a very positive and supportive environment for them. I help ESL students improve their confidence in speaking with native English speakers, pronunciation, vocabulary and conversational skills so that they feel proud speaking to others. I love learning about my clients' cultural/ academic backgrounds and interests and our classes are always fun and lively!
The subjects I tutor include: English, Writing, English as A Second Language (ESL), Essay Editing, Literature, Debate, Presentations, Persuasive Writing, Interview Skills, Writing Personal Statements for Undergraduate and Graduate School, Award Applications, Public Speaking, Art, Creative Writing, Poetry, Communication, Grammar, Vocabulary, Pronunciation, Confidence, Study Skills, Organization
ExperienceI have been an ESL and English tutor as well as an editor for both young and mature students for years. I have worked with a doctor, multiple business professionals and with many students from a diverse range of backgrounds and fields. I was a Teaching Assistant (TA) in two different courses at the University of Toronto, including a course called Effective Writing. For three years, I worked at a literacy camp for children. As a tutor, I draw on my talent for programming fun, personalized and stimulating activities to help students of all ages enjoy learning.
Please feel free to check out my website at www.ImpressYourProfs.com
HobbiesMy clients tell me that I am a very kind, encouraging, and compassionate person. I have a wonderful, very loyal base of clients who have stayed with me over the years. I care deeply about my clients and love helping them succeed at accomplishing their personal and academic goals. I have a positive and upbeat tutoring style. Many people I meet tell me that I am very funny and charismatic.
My current clients express great appreciation for my services and most opt for long-term arrangements.
I understand that all students have different needs and learn at different paces. I appreciate each person's unique abilities and work with students to inspire the best out of them as they tackle challenges.
As a visual artist, a poet and an entrepreneur, I am creative and resourceful.
I understand that tutoring is not just about getting better grades; it is also about feeling a sense of pride, confidence and accomplishment. Especially for students whose first language is not English, I understand the immense courage it takes to learn a new language and I treat students of all levels with compassion and sensitivity. I invest a great deal of time and effort into preparing sessions tailored to my clients' needs to help them gain a sense of confidence in their English skills and in themselves as people.
Preferred Subjects
Client Reviews (14)
Paloma is the best. Creativity, a profound knowledge of English, sound writing skills, the ability to analyze the subtleties of a text - she has it all. Plus she makes it fun! I highly recommend her to anyone looking to improve his mastery of English.
Learning and writing academic English is difficult for anyone. It is especially more challenging for ESL speakers. I was in this situation and to make my circumstances even more daunting, I was short of time. It is against background that I "met" Paloma. The patient, motivating and listening tutor guided me through the process and my writing improved one essay at a time. I recommend Paloma for any serious student - whether English is your first or fifth language - who is committed to improving their writing skills and grade.
Paloma is a very gifted English instructor. Her class is full of jokes and stories. You will be surprised that you are learning so much while having such a great time. She uses a variety of ways and tools to find your interests and needs to improve your English. Her delightful and calming personality makes you feel very comfortable and thus you will never be afraid or embraced to make any mistake. I could not be more thankful to her. I found a job within a week because of her help in editing my resume and cover letter. I am sure that choosing her as your tutor, you will never be regretted.
I was really impressed with the quality of Paloma work and I have high standards. She did an excellent job editing my son's admission letter with quick turnaround time. She has a knack for picking out all the main points in an essay, even suggests new ones, drawing relevant connections, and present them in a logical, concise, impactful manner that will leave the readers impressed. I highly recommend Paloma editing service!
Paloma is an extraordinary tutor. She has a natural enthusiasm for teaching and an excellent ability to communicate with people. A few weeks into the sessions, I can already see improvements in my writing. She is the only tutor who ever made a distinct, measurable difference in my performance. I now feel confident and proud of my accomplishments. She has really helped me learn to write!
One of the best tutors that I've ver had!!!!!!!!!! She's amazing and very well structured, bringing lots of clarity. Great source of help. Great session!!!!!
I cannot thank Paloma enough for helping me increase my literacy skills as well as my confidence in writing. I started my grade twelve year with barely knowing how to write a proper essay. I struggled to maintain a C mark and now i am proud to say that i am graduating with a definite A. Paloma's tutoring skills are fantastic and she really knows how to approach her students learning problems. Spending time with Paloma has inspired me to read more which helped me a lot wit my vocabulary skills. I strongly recommend this amazing curly haired young lady to anyone looking for an English tutor because she will definitely help you succeed in reaching your goal. -Mimi:)
I've worked with Paloma in preparation for Canadian scholarship applications. Throughout our time together, she has always been punctual, knowledgeable, and incredibly professional. She always found new and creative ways to present ideas and has given me great editing advice and support in terms of sentence structure, flow and tone.
Paloma has changed my life in the way I look at university learning. It makes me want to cry. Her techniques in study skills has lead me to believe how easy studying can be. Every session is carefully designed by her and builds on the last session. I'm with her for an entire year and look forward to each session as I learn new ways of how to study and analyze different types of reading which will eventually prepare me for essay writing. Thank-you Paloma for being the best tutor in the world!
I have been working with Paloma on improving my speaking and writing in English for a year, and she is the best!! Paloma is very sensitive to people who are learning new languages, and she is wonderful in teaching English. She is intelligent, resourceful, encouraging and supportive.Not only have we worked on pronunciation and writing, she has also helped me with persuasive communication, debating, interview skills, and essay editing. If you are looking for a long term English tutor, definitely contact Paloma!!!
I can confidently say that having Paloma as my English tutor was the best decision I made this summer. After two months of personalized and comfortable weekly sessions with her, my English skills have improved tremendously. For example, she has helped me with my English pronunciation, vocabulary, presentation skills, debating skills, writing skills and interview prep. I must say I was very impressed with how much efforts she puts in preparing for each session. I enjoyed her lessons a lot; in fact, she is resourceful, creative, fun and VERY smart! I highly recommend Paloma to everyone who wants to REALLY learn English. She is definitely a must contact person!
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The tutor will respond if they are available/interested.


text:
We, as a society, have been glued to our phones for too long. It's not healthy. Mobile phones have come a long way, but not all of the advances are positive. Phones have come so far that we're even describing them as "smart".
A snapshot of a public bus journey from anywhere in the UK 20 years ago would have featured passengers talking to each other or gazing out the window. The modern-day equivalent of that snapshot is alarming. We're not talking to each other, nor are we gazing out the window and appreciating the beauty of the world around us.
Instead, we are browsing social media sites at every opportunity and being made to feel inferior. We are staring at pictures of people that we don't know and cluttering our brain with a plethora of frantic thoughts.
We are giving ourselves an inferiority complex which, in turn, can lead to harmful feelings of anxiety. At a time when mental health awareness has never been more important, many of us are sabotaging our own happiness.
In this blog, the author is asking everybody to lock their phone away for one hour every day. Time spent asleep doesn't count.
Lock your phone away at a time when you are most likely to use it to aimlessly browse through social media sites like Facebook and Instagram.
If you get the bus to work, make a concerted effort not to look at your phone. Turn it off and put it in your pocket. Then, focus your attention on appreciating everything that is happening in the world around you. If somebody sits down beside you, offer them a warm smile and notice, in their expression, how they appreciate it.
Lock your phone away for one hour every day for an entire month, and acknowledge how enriched you feel for it. Slowly but surely your mind will become decluttered of all the Facebook posts that made you feel inferior, and all the pictures on Instagram that made you feel uneasy about your physical appearance.
Take the one-month challenge. Declutter your mind. Feel better in yourself.


text:
|21 Apr 2014
Problems with Windows Update
I followed the instructions provided for this problem and the SURT failed and gave this code: 0x800706be
Please help, I had a similar problem I thought I solved once I wrote 0s to my laptop. It just told me I needed to change the update setting to automatically 2 minutes after I turned it on. With this problem my internet browsers starts to lag badly.
Also I followed the instructions and zipped the CBS file but I get this error when I try to attach it: 500 internal server error: there is a problem with the resource you are looking for and it can not be displayed
Thank you!
|My System Specs
|21 Apr 2014
First try the simple troubleshooter:
Click , type troubleshooting. Click the result at the top for troubleshooting. Under the system and security category, choose fix problems with windows update. Run the troubleshooter, and then try to run windows update again.
Also try the following:
Fix the problem with Microsoft Windows Update that is not working
If this fails, try the following tutorial using option 3:
Windows Update - Reset
|My System Specs
|22 Apr 2014
Thanks, I just restored to an earlier date and it is working fine now.
|My System Specs
|22 Apr 2014
Ok, well if the issue occurs again defiantly try the above steps. Glad your running well now.
Don't forget to mark the thread solved!
|My System Specs
|22 Apr 2014
Will do, thanks!
|My System Specs
|Thread Tools
|Similar help and support threads
Problems during Windows Update
I'm not sure of the exact date, but it was around September 10th. I do remember that there was a security update to Net.Framework4.5.1. During the update the screen went blank and the computer died and then Re-Booted. That's when everything went sideways. I couldn't get any Updates for a couple but...
|Windows Updates & Activation
More Windows Update Problems?
Is anyone having trouble with the 3 Office 2007 updates for this month? They constantly reappear on my PC, even though the "Installed Updates" window says that they have been successfully installed. There is a thread on EightForums about it. Doesn't that make it 3 months in a row that...
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Windows 7 update problems
Hi. I'm having serious issues installing updates on my windows 7 laptop. There are three updates that I'm trying to install - They are: 1) security update for .NET framework 4 2) Update for windows 7 for x64-based systems (KB3349857) (I believe when I tried to manually download this update it...
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Windows Update problems(Windows Update cannot crrently check for...)
Windows Update cannot crrently check for updates, becouse the service is not running.You may need to restart your computer. That the problem i have with my windows udate in services.msc i dont have Windows Update folder file or whatever, when i bought my computer i remeber that i asked not to...
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Windows 7 SP1 Update problems
Hello guys, I've been trying to update my Windows 7 to SP1 (finally after waiting months) and I've been having problems with it. It keeps saying downloading 1 update (0 kb total, 0% complete). It's been like this for the past half an hour.
|Windows Updates & Activation
Windows update problems
Hi windows users, When i installed windows 7, There was a pop up that said i needed to install some optimal updates. So i did. and when the download completed (3files) There was no installing part, :sarc: When i look at my installed updates i don't saw them. I downloaded the dutch launge...
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Abbreviated rules 07/28/2017Underdawg did an excellent job of explaining the rules. Here's the simplified version: Don't insinuate Pedo. Warning and or timeout for a first offense. PermaFlick for any subsequent offenses Don't out members. See above for penalties. Caveat: if you have ever used your own real name or personal information here on the forums since, like, ever - it doesn't count and you are fair game. If you see spam posts, report it to the mods. We do not hang out in every thread 24/7 If you see any of the above, report it to the mods by hitting the Report button in the offending post. We do not take action for foul language, off-subject content, or abusive behavior unless it escalates to persistent stalking. There may be times that we might warn someone or flick someone for something particularly egregious. There is no standard, we will know it when we see it. If you continually report things that do not fall into rules #1 or 2 above, you may very well get a timeout yourself for annoying the Mods with repeated whining. Use your best judgement. Warnings, timeouts, suspensions and flicks are arbitrary and capricious. Deal with it. Welcome to anarchy. If you are a newbie, there are unwritten rules to adhere to. They will be explained to you soon enough.
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Rhode Island
Last year the PHRF fleet was 3 white sail boats - this might increase participation. The move is designed to try and help boost the PHRF participation. I think 2 years ago, they even killed off the PHRF fleet entirely. The entry into IRC can be daunting for someone with a Catalina 30 who wants to participate in his home clubs regatta. This gives him a low entry point, more relaxed race, and they get to enjoy the party at the end of the day with everyone else. One day makes it easier to secure crew commitments and is a good start for many people. The W/L is not killed off. You get two full days of it for the IRC and OD classes. Recently, (last 5 years), there has been very little to no PHRF participation at these events. Generally only 4-5 boats tops. RCYC rally race had a good handful, and seemed to be a success (barring the RC f'up). So rather than continuing to bang their heads against the wall, they are doing something to try and promote the racing. If you want to do W/L racing you can get an IRC rating, it is not that difficult, John is enthusiastic and willing to help you get measured or a temp rating. There have been a surprising number of smaller boats getting certs.
New Cubed - First Supermaxi Since Speedboat
misconseption2348 replied to MR.CLEAN's topic in Ocean Racing AnarchyThere are two removable inner headstays. Each deflector goes to one of these.
Zim 15
misconseption2348 replied to Jkdubz808's topic in Dinghy AnarchyYou would be surprised. The V-15 was very successful for a long time. As an example me and my buddy talked about getting one for a long time, and it just never came together. It might still, work in progress. The thing is we spent so long college sailing, that we wanted something similar, just the next step up. I've sailed I-14s, very complicated, expensive, steep learning curve. The cool thing about the V-15 is that the maintenance is extremely low. There is minimal to break, do some hull work every winter or so to keep up, but we're not replacing parts every time we go sailing. With no time or money, this is huge. The idea of showing up to the boat park, rigging in 7 min, being on the water with a bunch of other people our age, de-rigging in 7 min, is very compelling. Also because it is simple you can grab anyone to go sailing with you. No need to try and round up 4 more for a J24, cheap sails, and low maintenance. In Toronto there are about 300 albacores in the area. Friday night they regularly get 40-50 boats out. All for this reason. I would think this is easier to pull off in the NE where you have an abundance of ex college sailors floating around looking to relive the glory days once a week or month. I know it's not for everyone, but this is who the boat is for. Is it better than the V-15?
I have a soft vang. I was going to replace with ridgid, but my boom has the IMS holes cut in the boom to make it lighter. I didn't want to bend the boom, so just went soft. How does the rigid boom make it bend more? Isn't it just a spring pushing the boom up so it doesn't sag down? If you remove the solid piece you still have a soft cascade providing all the power... Mainsheet pulls down and ridgid vang pushes up......what do you think is going to happen? You reduce the pressure on spring/air/etc... If you are pulling that much load against the vang ram, you are not getting enough leech tension anyways.
I have a soft vang. I was going to replace with ridgid, but my boom has the IMS holes cut in the boom to make it lighter. I didn't want to bend the boom, so just went soft. How does the rigid boom make it bend more? Isn't it just a spring pushing the boom up so it doesn't sag down? If you remove the solid piece you still have a soft cascade providing all the power...
misconseption2348 replied to Whinging Pom's topic in Sailing AnarchyLooks like single centerline backstay instead of runners. Tough to tell though in the vid... Big head main, gotta wait for the end. you can see two sets of backstays early in the vid terminating near the center line.
need more everything
Aww I see. you guys should come play with us in IRC2
515 why is it showing your rating to be higher for this regatta? Looks like you suddenly gained some speed...
misconseption2348 replied to sarah0809's topic in America's Cup AnarchyOr TPT
I think there are a bunch of guys sailing F18's out of EYC. They had a big championship last year, does that count?
IRC NA's, IRC Canadians, 36.7 NA's, J24 Canadians, and Albacore worlds... There's a whole lot going on this summer.
Zoom and Nortius around the mark, Zoom later retired, Notorius was first to finish at T1. Just wondering what the point of redress is. It's hard enough to get participation as it is without the course being fucked up. Here come race our fall series, we might not actually get a real race in, but feel free pay the entrance fee to come out and freeze your ass off. Fun ride down hill though, topped out 16.2 back to national.
What are they going to give redress for? Does the race count in a series? Are they going to give average points? The fall LORC race series is suffering enough as it is, it will be interesting to see who does it again next year.
Was out on maggie kelly ben 40.7 last sat. little light and then lightningy, so we called it. Couple clubs have thier tune up races this week, most clubs start next week.


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Hyderabad, Andhra Pradesh India (PressExposure) May 24, 2011 -- Report Reserve announces addition of Suncor Energy Inc, Company Intelligence Report. To access this report please visit [http://www.reportreserve.com/reportdet.php?company=GlobalData&reportid=29061]
Suncor Energy Inc (Suncor) is an integrated energy company engaged in the exploration and production of crude oil and natural gas, refining and transportation; and the manufacture of petroleum products globally. Suncor has established operations in Canada, Syria, North Sea, and Libya. The company's upstream operations mainly include the exploration, development and production of crude oil, bitumen, synthetic crude oil and natural gas. Its heavy oil production includes bitumen produced from oil sands through mining and in situ technology and upgrades it into refinery feedstock, diesel fuel and by-products. Additionally, natural gas production includes natural gas, natural gas liquid and by-products located in Western Canada. Its international and offshore segment is engaged in the exploration and production of conventional oil and gas in offshore Newfoundland, North Sea, Libya and Syria.
- Key Highlights: This section provides detailed analysis on the company's overall oil and gas value chain, new projects, growth opportunities, new ventures, assets performance, hedging strategies, Capex funding, geographical results of oil and gas operations.
- Goals and Strategies: This section provides the upcoming goals and strategies of the company. The section mainly goals and strategies followed by the company in order to meet its upcoming goals.
- SWOT: The report's SWOT section provides the internal strength, weakness, opportunities and threats of company to reflect its strategic positions in the market.
- Key Events for 2011: This section provides the company's expected operational and financial activities in 2011. This section maps the company's focus for 2011 in nut shell.
- Production and Development Overview: This section highlights the company's crude oil and natural gas production forecast from its legacy and upcoming assets by region and commodity mix for next five years. The report also covers the detailed information and analysis on the company's producing and development assets.
- Exploration: This section includes detailed explanation and analysis on the company's exploration assets resulted due to new discoveries, new drilling and other activities.
- M&A trends: This section mainly provides information and analysis on the company's recent assets transactions, joint ventures, acquisition, and divestment activities during the last one year. This section highlights the company's status as a buyer or seller during the analyzed period.
- Financial Forecast and Valuation: This section highlights the detailed financial statement forecast for next five years. With the financial statement forecast, this section also provides intrinsic value of the company by using Net Asset Valuation method.
- Peer Group Analysis: This section compares the company's performance with its peer group on the basis of share prices, financial ratios, operational and financial parameters and other related parameters.
- Financial and Operational Metrics: This section covers the company's historical performance on several financial and operational parameters such as Production and Reserves, Reserves Replacement, Costs Incurred, Acreage, Wells, F&D Costs, Oil and Gas Revenue and Expenses etc.
Reasons to buy
The report will enhance the decision-making capability in a more rapid and time sensitive manner. It will allow you to -
- Provide detailed analysis to those who are interested in knowing the companies' existing and future business strategies.
- Provide in-depth analysis on the companies E&P profiles along with the exploration and M&A updates.
- Provide valuable insights to those who are tracking oil and gas markets and wants to know the intrinsic value of the companies.
- Use the analysis for strategy and planning, M&A identifications, and competitor analysis.


text:
The role of the Academic Senate, as
delineated by AB 1725, gives the faculty primary responsibility for
making recommendations to or reaching agreement with the President on
academic and professional matters. As delineated by law, the president
consults collegially with the Senate on the following academic and
professional matters:
1. Academic and Professional Matters. The Academic Senate shall consult collegially with the College President, as the designee of LACCD Board of Trustees, to develop policies on academic and professional matters through either or both of the following methods as provided in California Code of Regulations, Title 5, Article 2, Section 53200:
a. The College President shall
rely primarily on the advice and judgment of the Academic Senate; orb. The
College President and the representatives of the Academic Senate shall have the
obligation to reach mutual agreement by written resolution, regulation, or
policy effectuating such recommendations.
1. Curriculum, including establishing prerequisites and placing courses within disciplines 2. Degree and certificate requirements 3. Grading policies 4. Educational program development 5. Standards or policies regarding student preparation and success 6. District and college governance structures, as related to faculty roles 7. Faculty roles and involvement in accreditation processes, including selfstudy and annual reports 8. Policies for faculty professional development activities 9. Processes for program review 10. Processes for instructional planning and budget development, and 11. Other academic and professional matters as mutually agreed upon between the governing board and the Academic Senate.
4. Additional Functions. The Academic Senate shall assume responsibilities and other functions as may be delegated to it by state law, the LACCD Board of Trustees' rules, or this Constitution.
Ex Officio Members: