text:
33 on Wye - located at Wye River
House, Wye River
Rated 4.5 out of 5 stars 7 reviews
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Min 2 - 7 nights stay
This modern 2 storey, 3 bedroom house, is a delightful 600 metre walk or drive from the beach. Views of ocean and picturesque Wye valley from balcony, perched high in the surrounding treetops. The home is well-appointed with all new furnishings.
Upstairs is a large living area with adjacent balcony. It includes a leather couch and chaise, plasma TV, DVD player and entertainment unitincluding ipod dock, large recycled timber table for dining, and a fully equipped kitchen catering to all cooking needs.
The three bedrooms are downstairs, and offer 1KB,1QS and 1 bunkers lo-line bunk with trundle. Another separate living area with plasma TV and DVD player, bathroom with bath and shower, and separate laundry.
Air conditioning and heating on both levels.
Outdoor setting and gas BBQ on balcony.
For guests with young children, a porta cot and high chair is available.
Fall asleep to the sound of the ocean and wake to the sounds of the birdlife.
Location and things to do..
Wye River is a picturesque location, with the river and surf beach nestled between the surrounding hills. A quiet coastal community, where you will want for nothing. Beach, bush, marine and wildlife, fishing, all at your doorstep.
The General Store has a wide range of produce available, it's adjoining cafe provides great food, coffee and beverages, and exceptional bread and pastries- all made fresh on the premises and available all year round.
The Wye pub also offers meals and arguably has the best beer garden in Australia.
A delightful place to visit and stay all year round, just over 2 hours drive from Melbourne, and only 15 minutes from Lorne or 20 minutes from Apollo Bay.
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text: I've been looking for a good revolver, and I think I found a few good options within my budget. I wanted to get a few opinions on them though. Taurus Tracker (Gen 1) - .41 Magnum in really good condition - $400 Ruger Security Six (6" barrel) - .357 Magnum in good condition. A little finish wear. - $429 Taurus Model 65 (5" barrel? Adjustable sights) - .357 Magnum in good condition with a little wear. - $329 Smith and Wesson 19-5 (4" barrel) - .357 Magnum in good condition, but with a lot of holster wear. - $375 Ruger Speed Six (2.75" barrel) - .357 Magnum in really good condition. - $375 Here's what I'm wanting. I'm wanting a gun that is accurate, can handle reasonably hot rounds, and it will be mostly a range gun. Ammo cost and availability doesn't matter since I plan to reload anyways, and weight doesn't matter much either. (unless it's too light for the round, and makes the gun uncomfortable to shoot) I'm kind of leaning towards either the Ruger Service Six, or the Taurus Model 65.

subset: commoncrawl


text: Sporting an espresso finish, the 24? Bar Stool is inspired by the best-selling wheat back design to lend your decor a hint of charm and sophistication. Defined by its flared back with a grid-like pattern, this stool has a comfortable swivel seat with leather-like vinyl upholstery that is easy to maintain. Supporting the durable frame of the chair are its flared legs, which have a round footrest between them. The 24? Bar Stool flaunts a deep espresso wood finish and transitional style and is made from wood veneers and solids.


text:
What would Death himself do if he were surrounded by ultra-cute critters? Kill them, of course! You play the reaper, who needs to kill red cuties in order to stay alive. Killing other cuties will help charge super powers that make it easier to get to the red cuties. How long can you survive before the dwindling cutie population stifles your life? You can't help but have a bloody fun day in this addictive puzzler.
You are the Reaper! Click an adjacent hexagon to attack it. Click one of the buttons along the button to activate your special power (if it has powered up).Your health decreases every time you make an attack, but killing red cuties will give you back health.
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text:
Traveling Luck for Bacon Creek Campground (historical), Washington, United States
Where is Bacon Creek Campground (historical)?What's around Bacon Creek Campground (historical)?
Wikipedia near Bacon Creek Campground (historical)
Where to stay near Bacon Creek Campground (historical)
The timezone in Bacon Creek Campground (historical) is America/Whitehorse
Sunrise at 07:28 and Sunset at 16:16. It's Dark
Latitude. 48.5875°, Longitude. -121.3939°
Weather near Bacon Creek Campground (historical); Report from Agassiz Automated Reporting Station , 61.2km away
Weather :
Temperature: 6°C / 43°F
Wind: 2.3km/h South/Southeast
Weather :
Temperature: 6°C / 43°F
Wind: 2.3km/h South/Southeast
Satellite map around Bacon Creek Campground (historical)
Loading map of Bacon Creek Campground (historical) and it's surroudings
Geographic features & Photographs around Bacon Creek Campground (historical), in Washington, United States
- stream;
- a body of running water moving to a lower level in a channel on land.
- Bacon Creek (0.1km)
- Copper Creek (1.8km)
- Alma Creek (3.2km)
- Diobsud Creek (3.8km)
- Oakes Creek (4.2km)
- Steelhead Creek (5.2km)
- Taylor Creek (5.9km)
- Falls Creek (6.3km)
- Damnation Creek (7km)
- Olson Creek (7.3km)
- Sky Creek (7.8km)
- Backus Creek (8.1km)
- Jumbo Creek (8.4km)
- Clark Creek (8.5km)
- Cascade River (8.5km)
- Jordan Creek (8.6km)
- Helen Creek (9km)
- Day Creek (9.1km)
- Boulder Creek (9.2km)
- Irene Creek (9.4km)
- East Fork Bacon Creek (9.8km)
- Lookout Creek (10.5km)
- Thorton Creek (10.8km)
- Monogram Creek (11.1km)
- Marble Creek (11.8km)
- Patent Creek (12.4km)
- Corkindale Creek (12.9km)
- Martin Creek (13.2km)
- Triumph Creek (13.5km)
- Haystack Creek (13.6km)
- Babcock Creek (13.6km)
- Rocky Creek (13.8km)
- Local Feature;
- A Nearby feature worthy of being marked on a map..
- Bacon Creek Campground (historical) (0km)
- Bacon Creek Siding (historical) (0.3km)
- Stewart Siding (historical) (2.2km)
- Bacon Point Lookout (2.4km)
- Jennings Siding (historical) (3.6km)
- Lookout Mountain Lookout (7.1km)
- Sky Creek Siding (7.5km)
- Cascade Island Campground (7.8km)
- Cascade Islands Campground (7.8km)
- Marble Creek Campground (11.9km)
- mountain;
- an elevation standing high above the surrounding area with small summit area, steep slopes and local relief of 300m or more.
- Bacon Point (2.4km)
- Lookout Mountain (7.1km)
- Diobsud Buttes (7.9km)
- Oakes Peak (8.4km)
- Big Devil Peak (8.8km)
- Helen Buttes (9.2km)
- Damnation Peak (10.6km)
- Little Devil Peak (10.7km)
- lake;
- a large inland body of standing water.
- Olson Lake (7.7km)
- Monogram Lake (10.4km)
- Triumph Lake (11.7km)
- Buller Lake (12.5km)
- Thornton Lakes (13.7km)
- populated place;
- a city, town, village, or other agglomeration of buildings where people live and work.
- Portage (0.6km)
- Marblemount (8.8km)
- Corkindale (11.9km)
Accommodation around Bacon Creek Campground (historical)TravelingLuck Hotels
Availability and bookings
- ridge(s);
- a long narrow elevation with steep sides, and a more or less continuous crest.
- Teebone Ridge (10.8km)
- mine(s);
- a site where mineral ores are extracted from the ground by excavating surface pits and subterranean passages.
- Skagit Talc Mine (historical) (4.9km)
- forest(s);
- an area dominated by tree vegetation.
- Marblemount Ranger District (7.1km)
Wikipedia entries close to
Bacon Creek Campground (historical)
- Marblemount, Washington city city o
- Mount Despair mountain mountain k
- Rockport, Washington city city o
- Davis Peak (Washington) mountain mountain k
- Colonial Peak mountain mountain k
- Mount Terror (Washington) mountain mountain k
- Johannesburg Mountain mountain mountain k
- Concrete, Washington city city o
- Cascade Pass mountain pas
- Luna Peak (Washington) mountain mountain k
- Mount Shuksan mountain mountain k
- Boulder Glacier glacier
- Mount Baker mountain mountain f
- Wikiproyecto:Montañas
- Mount Goode (Washington) mountain mountain k
- Jack Mountain mountain mountain k
Airports close to Bacon Creek Campground (historical)
Chilliwack(YCW), Chilliwack, Canada (84.5km)
Abbotsford(YXX), Abbotsford, Canada (97.8km)
Bellingham international(BLI), Bellingham, Usa (99km)
Whidbey island nas(NUW), Whidbey island, Usa (110.2km)
Snohomish co(PAE), Everett, Usa (114.3km)
Airfields or small airports close to Bacon Creek Campground (historical)
Photos provided by Panoramio are under the copyright of their owners.


text:
AP Source: Rockets reach agreement for Terry
HOUSTON — A person with knowledge of the deal says the Houston Rockets will acquire guard Jason Terry in a trade with Sacramento.
The person spoke on condition of anonymity because the deal had not been completed.
The Rockets will also receive two second-round draft picks and send guard/forward Alonzo Gee to the Kings, along with at least one other non-guaranteed contract.
|The article you requested is no longer available on BostonHerald.com.


text:
Steady shear stress stimulates transient hyperpolarization coupled to calcium-sensitive potassium (KCa) channels and sustained depolarization linked to chloride-selective channels. Physiological flow is pulsatile not static, and whereas in vivo data suggest phasic shear stress may preferentially activate KCa channels, its differential effects on both currents remain largely unknown. To determine this interaction, coronary endothelial cells were cultured in glass capillary flow tubes, loaded with the voltage-sensitive dye bis-(1,3-dibutylbarbituric acid)trimethine oxonol, and exposed to constant or pulsatile shear stress. The latter was generated by a custom servoperfusion system employing physiological pressure and flow waveforms. Steady shear induced a sustained depolarization inhibited by the Cl- channel blocker DIDS. Even after exposure to steady flow, subsequent transition to pulsatile shear stress further stimulated DIDS-sensitive depolarization. DIDS pretreatment "unmasked" a pulsatile flow-induced hyperpolarization of which magnitude was further enhanced by nifedipine, which augments epoxygenase synthesis. Pulse-shear hyperpolarization was fully blocked by KCa channel inhibition (charybdotoxin + apamin), although these agents had no influence on membrane potential altered by steady flow. Thus KCa-dependent hyperpolarization is preferentially stimulated by pulsatile over steady flow, whereas both can stimulate Cl--dependent depolarization. This supports studies showing greater potency of pulsatile flow for triggering KCa-dependent vasorelaxation.
- calcium-sensitive potassium channels
- steady shear stress
- vasorelaxation
- endothelium-derived hyperpolarizing factor
the endothelium is the primary sensor for changes in shear stress. This signaling has been recently reviewed (8, 11, 17, 29) and involves activation of specific integrin-focal adhesion kinase cascades, G proteins, intracellular Ca2+, pH, and tyrosine and serine-threonine kinases. Steady shear also induces intracellular hyperpolarization by stimulating apamin-charybdotoxin (AP-CbTX)-sensitive potassium channels (3, 6) and voltage-sensitive K+ inward rectifying current (14). In addition, lower levels of steady shear activates a sustained depolarizing Cl--selective current (1) that can override membrane hyperpolarization.
Whereas the majority of studies have examined responses to steady shear, in vivo flow is generally pulsatile, and phasic versus constant shear stress can trigger very different and even opposite responses in endothelial signaling. This has been demonstrated for nitric oxide synthase and Akt activation (4, 24), endothelial intracellular pH (pHi), mitogen-activated protein (MAP) kinase, cSRC tyrosine kinase activation (32), and G protein signaling (7). There are virtually no data to date assessing whether different voltage changes are also triggered in response to pulsatile versus static shear. Such differential signaling seems plausible, however, given that pHi can affect membrane potential change induced by carbonyl cyanide p-trifluoromethoxyphenylhydrazone (23).
The present study tested the hypothesis that pulsatile shear stress differentially modulates membrane potential. Effects of steady versus pulsatile flow on endothelial membrane potential were examined using a novel servoperfusion system that exposed endothelial cells cultured in microcapillary tubes to physiological pulsatile pressure and flow while simultaneously monitoring potential by the fluorescent dye bis-(1,3-dibutylbarbituric acid)trimethine oxonol (DiBAC4). The results provide the first evidence of differential effects of pulsatile and steady flow on endothelial membrane potential, with preferential stimulation of KCa-dependent hyperpolarization by pulsatile versus steady shear stress.
Cell culture. Bovine coronary endothelial cells (BCECs, Clonetics; San Diego, CA) were grown to passage 4–8 in culture medium supplemented with 5% FBS, 10 μg/l human recombinant epidermal growth factor, 1 mg/l hydrocortisone, 50 mg/l gentamicin, 50 μg/l amphotericin-B, and 12 μg/l bovine brain extract (Clonetics) in 37°C humidified atmosphere of 95% air-5% CO2. After exposure to 0.25% trypsin and 0.5 mM EDTA (Clonetics), cells were plated either in 1% gelatin (Sigma Chemical; St. Louis, MO)-coated 1 mm2 × 5 cm borosilicate glass capillary tubes (VitroCom; Mountain Lakes, NJ) or on 25-mm diameter circular glass coverslips. Cells were grown to confluence for ∼48 h before the study.
Measurements of membrane potential. Membrane potential was assessed using the fluorescent dye DiBAC4 (Molecular Probes; Eugene, OR). Cells were washed and incubated in HEPES buffer (see Reagents) containing 0.5 μM of DiBAC4 at 37°C 15–30 min. Preliminary studies were also performed in physiological buffer containing bicarbonate as previously described (32), although prior investigation found no difference in the Cl--mediated response between HEPES and -containing buffer (1). Furthermore, whereas acidification with steady flow is buffer dependent, pulsatile shear-induced alkalinization is similar with either (32). Both buffers were gassed with 5% CO2-95% O2 to maintain physiological pH. Monolayers were mounted on the stage of a modified Nikon Diaphot inverted epifluorescence microscope. Fluorescence was excited with a 75-W xenon short-arc lamp (UXL-75, Ushio, Japan) at 480 ± 20 nm, and fluorescence was collected in real time at 535 ± 25 nm.
Pulse pressure servopump system. Pulsatile perfusion was generated by a custom servopump system as previously described (25, 32). Mean flow was generated by a nonpulsatile flow pump, and realistic pulse pressure and flow waveforms were superimposed by means of an electromagnetic linear motor (Applied Engineering) controlled by real-time digital feedback. The servosignal was a previously recorded aortic pressure wave that could be modified to yield desired pulse amplitude and mean. An inline flowmeter (1N, Transsonic) placed just upstream of the capillary tube recorded phasic flow. A downstream hydraulic resistor placed in the outflow line was used to set mean pressure for a given mean flow.
Reagents. DIDS, CbTX, AP, and epoxyeicosatrienoic acids (EETs) were obtained from Sigma Chemical. Nifedipine and bradykinin were obtained from Calbiochem. 1,3-Dihydro-1-[2-hydroxy-5-(trifluroromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one (NS-1619) was obtained from Sigma RBI. For most studies, the perfusion buffer contained (in mM) 150 NaCl, 4 KCl, 1 CaCl2, 2 MgCl2, and 10 HEPES (pH adjusted to 7.4 with NaOH). Cl--free HEPES contained (in mM) sodium aspartate 137, potassium aspartate 4.9, MgSO4 1.2, NaH2PO4 1.2, d-glucose 15, HEPES 20, and calcium gluconate 1.5 (pH adjusted to 7.4 with NaOH). The perfusion buffer contained the same concentration of bisoxonol dye as that in which the cells were incubated during experiments to prevent concentration gradient-driven dye washout from the cells.
Experimental protocols. BCECs were first perfused using nonpulsatile steady low-level flow (< 0.1 ml/min) at a mean pressure of 90 mmHg with perfusion buffer. After several minutes to allow for stabilization of the fluorescence signal, flow was increased and maintained at 0.7 ml/min (1 dyn/cm2) at the same pressure for at least 10 min or until fluorescence intensity stabilized. Perfusion was then switched (typically 500 s after onset of steady flow) to pulsatile flow (90 mmHg pulse pressure at the identical mean flow and mean pressure), and this condition was maintained for 15 min or more. In additional studies, the effect of transitioning from minimal flow directly to pressurized pulsatile perfusion was also examined to assess for any accommodation response to preexposure to steady flow.
Statistical analysis. Data are reported as means ± SE. Statistics comparisons were made using the Student's t-test for paired and unpaired groups.
Steady versus pulsatile shear stress effects on endothelial voltage. Figure 1, A–E, displays example tracings for protocols in which endothelial cells were first exposed to steady shear stress and then abruptly switched to pulsatile shear at the identical mean pressure and flow rate. Summary results are provided in Fig. 1E. With the acute onset of steady shear, intracellular voltage (Vi) rose (i.e., a depolarization) reaching a steady state within several minutes (Fig. 1A, control HEPES buffer on left, physiological buffer on right). Once stabilized, this depolarization was maintained until shear stress was discontinued (data not shown), as previously reported (1). However, when steady shear stress was changed to pulsatile shear, there was subsequent further depolarization, which also quickly reached a plateau. The magnitude of depolarization triggered by initial exposure to steady shear stress was more than twice that observed following the transition to pulsatile shear stress (Fig. 1E). In separate studies, we initiated shear stress in the pulsatile mode, and the response was similar to that observed when pulsatile shear followed steady shear (data not shown). Results using physiological -containing buffer were qualitatively similar to those with HEPES buffer, although the relative magnitude of steady versus pulsatile shear stress-induced depolarization was slightly larger with the buffer (P < 0.05).
Because a shear-activated Cl--selective depolarizing current was previously documented in endothelial cells subjected to flow, experiments were performed using the Cl- channel blocker DIDS (1 mM × 1 h; and same concentration added to perfusate during study). DIDS reduced the magnitude of the steady shear stress-induced depolarization by slightly >50% (P < 0.001) and converted the depolarization previously observed when changing to pulsatile shear stress to a hyperpolarization (P < 0.05; Fig. 1, B and E). These results suggest that pulsatile shear stress activates both a depolarizing Cl- current and a hyperpolarizing current, the net response being depolarization under control conditions. Cl- channel inhibition "unmasked" the pulsatile shear-induced hyperpolarizing membrane current.
Shear stress has been reported to stimulate endothelial-derived hyperpolarizing factors (EDHFs) (2), which may include cytochrome P-450-derived EETs (3, 6, 10). Studying EET signaling in vitro can be difficult because these signaling pathways are downregulated in cultured endothelial cells. To study the role of EET in pulsatile flow-induced hyperpolarization, endothelial cells were first preincubated for 24 h with 10 μM nifedipine because this treatment enhances endothelial cytochrome P-450-derived EET production in endothelial cells(9). Nifedipine pretreatment had no influence on the depolarizing response to steady shear stress, but the subsequent pulsatile shear-induced depolarization was blocked, converting to a hyperpolarization (P = 0.058; Fig. 1, C and E). Finally, exposure to both nifedipine pretreatment and DIDS (Fig. 1D) yielded steady shear depolarization similar to DIDS alone but more consistent hyperpolarization with pulsatile shear stress (P = 0.0001, Fig. 1E). Similar results were obtained by adding nifedipine to Cl--free medium (data not shown). These data are consistent with a differential effect of pulsatile versus steady flow on endothelial membrane potential, with a Cl--dependent depolarizing current triggered by both stimuli but Cl--independent hyperpolarizing current more tightly linked to pulsatile shear.
KCa activation by pulsatile versus steady perfusion. To test whether hyperpolarization with pulse-perfusion in the presence of nifedipine pretreatment and DIDS was due to KCa activation, studies were performed with pharmacological inhibitors of these channels. Bradykinin (1 μM) and the KCa agonist NS-1619 (30 μM) were first used to show that, in the absence of a shear stress stimulus, agonists known to hyperpolarize via KCa stimulation (12) do so in this model (Fig. 2, A and B). Both agents induced hyperpolarization stabilizing over several minutes. Whereas this response was considerably slower than that reported with direct electrophyisiological recordings (5, 12), it was similar to prior data with DiBAC4 (20). Hyperpolarization was also confirmed in response to EET13,14 (-0.2 ± 0.04 unit change, P < 0.02, data not shown). Preincubation with CbTX (100 nM) and AP (200 nM) inhibited bradykinin hyperpolarization by >50% (not shown).
Studies were next performed to test the relevance of CbTX + AP inhibition of KCa currents on altered intracellular voltage induced by steady versus pulsatile shear stress. For these studies, endothelial cells were pretreated with nifedipine and DIDS to unmask hyperpolarization. Rapid depolarization induced by steady shear stress was unaltered by KCa channel blockade. However, hyperpolarization induced by pulsatile shear stress was fully blocked by CbTX + AP (Fig. 2, C and D).
The present study is the first to demonstrate differential responses of endothelial cell voltage to steady versus pulsatile shear stress. As previously reported (1), steady flow triggered a DIDS-sensitive depolarizing current thought due to Cl-, and this current was further activated by a transition to pulsatile flow. However, the latter response was smaller and appeared to reflect coactivation of an AP-CbTX-sensitive hyperpolarizing current, consistent with KCa stimulation. Hyperpolarizing responses were enhanced by nifedpine pretreatment, which upregulates epoxygenase synthase. These results suggest different channel activation by steady versus pulsatile shear stress and support in vivo findings showing a greater influence of EDHF-KCa-dependent vasodilation by augmented pulsatile perfusion (22).
Several methodological issues related to the perfusion system and fluorescent probe used to assess voltage should be noted. As pressurization was required to generate phasic shear stress [pressure was servocontrolled (25)], patch-clamp analysis was precluded. Although DiBAC4 fluorescence provided an alternative, its kinetics were slower than those measured by direct electrical recordings [e.g., bradykinin response (5, 12)] reflecting both dye properties (20) and mixing in our flow system. However, the behavior of the signal in the presence of KCa antagonists supported its indexing similar membrane currents.
In addition to slower kinetics, higher shear stress cannot be studied with DiBAC4 because this generates an immediate artifactual signal due to nonspecific interaction of the dye with flow (1). We also confirmed this in our system using preincubated cells killed by exposure to hypoosmotic solution. Whereas there was no signal change with bradykinin in such cells, rapid shear stress-induced depolarization was observed at >5 dyn/cm2. At the mean shear stresses used in the present study (1 dyn/cm2) there was no such artifact.
The depolarizing response to steady shear stress observed in the present study is similar in time course and amplitude to that reported by Barakat et al. (1). We further provide novel evidence that cells already flow adapted to steady shear stress exhibit further depolarization by a DIDS-sensitive current. In contrast to the prior study, we did not observe an early rapid hyperpolarization on shear initiation and were unable to fully inhibit the depolarizing current with DIDS or diphenylamine carboxylate. A potential cause for this difference was the use of low-passage bovine coronary endothelial cells in the present work compared with late passage (15–25) bovine aortic endothelial cells in the earlier study.
Unlike the depolarizing Cl- current that was activated by both steady and pulsatile shear, stimulation of a KCa channel-dependent hyperpolarizing current appeared to only be present with pulsatile shear. Whereas AP + CbTX blocked hyperpolarization induced by bradykinin or NS-1619 as well as pulsatile shear stress (12, 30), blockade of small and intermediate KCa channels had no effect on voltage responses to steady shear stress. This means that either the magnitude of depolarizing current with steady shear was so large that KCa activation could not overcome it or stimulation of KCa channels was favored during pulsatile perfusion in our model system. Evidence favoring the latter interpretation stems from data showing that amplification of EDHF signaling by nifedipine did not alter voltage responses to steady shear stress, but rather only to pulsatile shear stress, where depolarization was converted to hyperpolarization. Furthermore, the effect of DIDS on the depolarizing current was similar with both steady and pulsatile shear stress, yet its net impact was more marked with the latter, supporting coexistence of a more prominent hyperpolarizing current. It is possible that at higher shear stresses, the hyperpolarizing current would be of greater magnitude, although the current data may well be relevant to conditions of lower mean shear such as bifurcation points in vivo.
Although this is the first study to examine the effects of pulsatile versus steady flow on endothelial membrane potential, several previous studies have shown that the vascular endothelium can distinguish between the types and rates of change of shear stress. Differential signaling responses during pulsatile versus steady flow have been described for intracellular Ca2+ (13, 15, 28), pHi, tyrosine kinase and MAP kinase signaling (32), and cytoskeletal organization and orientation (16). We previously showed that pulsatile shear induces intracellular alkalinization (32), whereas steady shear stimulates a decrease in pHi (31, 33). This is intriguing because in smooth muscle cells, intracellular alkalinization enhances single large KCa channel activity and current amplitude, whereas acidification has the opposite effect (19, 27).
The mechanisms by which endothelial cells differentiate between phasic versus static shear stress remain to be elucidated. Whereas much work has evolved regarding specific integrins and kinase activation cascades stimulated by static shear stress (18, 21, 26), little is known about how these same processes are modulated by phasic shear stress. The question is clearly relevant as most in vivo vascular biology occurs in the setting of phasic stress that can have potent effects on cell signaling and cytoprotection (24). Experimental systems such as that employed in this study and others to provide realistic pulsatile stimuli under highly controlled conditions should help provide these needed insights.
This study was supported by National Heart, Lung, and Blood Institute Grants HL-47511 (to D. A. Kass) and HL-63720 (to R. C. Ziegelstein).
The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
- Copyright © 2003 by the American Physiological Society


text:
How To Return An Item
Your item must be in its original unused condition to be returned, unless there is a manufacturer defect. You must return the item within 14 days of your purchase.
1. Please mail your returned item to:
Paragon Enterprise Limited
Central Boulevard
Blythe Valley Park
United Kingdom
2. Please clearly label your package outside that it is a return and include in your package a signed letter stating the reason for your return.
3. Please maintain postage proof of return
Return Exceptions
Returns of any used items or not in original packing will be rejected unless there is a manufacturer defect
Restocking Fee
All items are subject to a 15% restocking fee, this will be deducted from your refund. We also do not refund postage and handling costs paid on the order.
We will consider item exchange if returned item is unused and in its original packing. Any return however will be liable to any postage and handling costs.


text: Jagger Mick Mick Jagger Couple more years. Fogerty John John Fogerty 1945 Stewart Rod Rod Stewart You don't have to go. Clapton Eric Eric Clapton Country rock music Honk tonk woman. Sweet little sixteen. Richards Keith Keith Richards 1943 King B. B. B. B. King Ol' Glory. 71752536 Honky-tonk music 2006 Rock music His first studio album since '95 is a celebratory outing, featuring a stunning cast of guest musicians ranging from Kid Rock to Toby Keith and Eric Clapton. Collaborating with guitarist Jimmy Page, the album features 21 lively tracks. ℗2006 Last man standing 71752536 Jerry Lee Lewis, last man standing Country rock music en Artists First Kid Rock (Rapper) Kid Rock 2001-2010 Robertson Robbie Robbie Robertson Just a bummin' around. Henley Don Don Henley Page Jimmy Jimmy Page What makes the Irish heart beat. Guy Buddy Buddy Guy Travelin' band. Honky-tonk music Rock and roll. Rock music--2001-2010 Wood Ron Ron Wood 1947 That kind of fool. Haggard Merle Merle Haggard Little Richard Little Richard 1932 Nelson Willie Willie Nelson 1933 Evening gown. Guralnick Peter Peter Guralnick Hadacol boogie. xxu Lewis Jerry Lee Jerry Lee Lewis I saw her standing there. Last man standing. Online version: Don't be ashamed of your age. Jones George George Jones 1931 2013 Pilgrim. Bramlett Delaney Delaney Bramlett 1939 2008 Young Neil Neil Young 1945 2017-10-23 ℗2006 Lost highway. Rock music Trouble in mind. Starr Ringo Ringo Starr Keith Toby Toby Keith Springsteen Bruce Bruce Springsteen Compact disc Twilight. What's made Milwaukee famous. Kristofferson Kris Kris Kristofferson Before the night is over. Pink Cadillac. United States


text:
Cape Town - City of Cape Town officials have denied knowing anything about an incident in which a little girl was run over by a municipal refuse removal truck, resulting in her losing her leg.Iviwe Mehlo, 3, from Philippi had to have her leg amputated after the accident in 2010, reported Eyewitness News.Her mother, Mandisa, said she was worried about the child's future as she had to be carried around everywhere and could not play with other children.Mandisa said Iviwe was getting too heavy to be carried around on her back.She said she wanted Iviwe to be fitted with a prosthetic leg and to be able to go to school one day.Mehlo said a lawyer told her she could only claim from the Road Accident Fund in five years' time.City officials say they have no record of the incident.Police officials confirmed the incident and said a case docket had been sent to the senior public prosecutor for a decision.
Typical of the municipality!!!!
The lawyer was clearly a shyster of some kind - 5 years before you can claim from the RAF? WTF! You claim immediately! I hope this woman gets the help she needs from someone who knows what they're doing.
there is no recording what he said, it could have been "it can take up to 5 years" , just cause its in the news paper does not make it accurate and true :P
What was the kid doing in the road in the 1st place?
Was she playing? And why was'nt the mother paying closer attention?
'what was the kid doing in the road, in the first place' you are surely kidding? She was probably playing in the road because in Phillipi the residents MORE THAN LIKELY do not have 1500 square metre fenced properties with swimming pools and swings and slides, so......kids have nowhere else to play. Perhaps I am wrong, and you can enlighten me and the readers?


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Welcome to Davis & Taft, a store which mixes antiques with 20th century modern design. The ever-changing inventory features lighting by Italian designers including Joe Colombo, Harvey Guzzini, Massimo Vignelli, and Reggiani.
Furniture is selected for its quality and simplicity. Expect to find 18th century commodes mingling with 20th century Danish credenzas. The effect is vibrant, fresh and timeless. Life is a pleasure and how we live can be an acknowledgment of this. Salutations to life… that is what you will find here.


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Posts Tagged with "directv"
NFL Sunday Ticket Student Discount: Up To 50% Off
As the NFL season begins, DirecTV is offering a big discount for students purchasing their NFL Sunday Ticket streaming service. The package lets you stream most NFL games on any device no matter where you're at. When you combine the student discount it's one of the cheapest and easiest ways to watch football anywhere. You will receive NFL Sunday Ticket for 4 months, covering most of the season, for just
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DirecTV NFL Sunday Ticket Free with Select Packages
As the NFL season approaches, DirecTV is starting to release all of their promotions and deals available for the popular NFL Sunday Ticket. Just like last year you can get NFL Sunday ticket free or included with many of the bundled packages available. The most popular package to get NFL Sunday Ticket included is to choose the "Choice" plan. This plan starts at a discounted price and not only gives you Sunday Ticket for free but also HBO, Showtime, and Starz free for
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Dish Network vs. DirecTV
Our guide for satellite TV in which we compare Dish Network and DirecTV, the two major players in the space. Deciding between the two and deciding which service is right for you can be tough with the dozens of different packages and options available along with different prices and channels. Before you make the commitement to purchase one of the two you should know all of the options available to make sure that you make the right choice. Below is our guide in which we review and compare all aspects of both services clear down to their options for cheapest packages, sports packages, and Latino language options.
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Card Games Properly Explained Paperback
by Arnold Marks
If you have never played cards before, this book is the ideal introduction. Or if you have a basic idea of the rules of some games, it will help you extend your existing knowledge and add new games to your repertoire. You will learn all the basic rules, understand the reasons why players play certain cards, discover the winning strategies and always be able to play the right card at the right time.The book covers all the most popular card games, including: Whist, Solo, Napoleon, Clobbiosh, Belot, Black Maria, Piquet, Five Hundred, Poker, Brag, Cassino, Rummy, Kaluki, Gin Rummy, Canasta, Cribbage and Pontoon.
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- Publication Date: 28/10/2010
- Category: Card games
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Our site begins provide tons of Cran-Dol-video stuff again! Check out our video-section. It' working again! We just begin to restore all stuff, so there will be much more video! Check the site for updates. More Cran-video everyday!
Right now you can download Dolores' 2007 concert Avo Sessions + 12 live-videos
Really exclusive videos (including great-quality Moscow 2007 concert) will be available soon. Have fun! The Cranberries forever!
Случайные записи
3.02.2009 in category News | No comments


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Cannes 2016: Aishwarya Rai Bachchan Strikes Gold At The Red Carpet
13/05/2016 10:10 PM IST | Updated 15/07/2016 8:26 AM IST
Ankur Pathak Bollywood Editor
Aishwarya Rai Bachchan, a veteran at the Cannes Film Festival, made her opening 2016 appearance today evening in the French Riveria.
The actress, who made a comeback last year with Jazbaa, looked resplendent in a golden Ali Younes beaded cape couture gown.
While she's representing Loreal, the cosmetic giant she endorses, a movie premiere of Sarbjit, where she's essaying the role of Dalbir Kaur, is also scheduled in the coming days.
Here, have a look at the pictures.
Aishwarya Rai Bachchan's Iconic Move #Cannes2016 pic.twitter.com/3sY9qEflCJ— A Fashionistas Diary (@afdiaries) May 13, 2016
Aishwarya Rai in gold this year 😍 about walk the red carpet #Cannes2016 pic.twitter.com/Wxw5idPPbk— 100YrOf IndianCinema (@100IndianMovies) May 13, 2016
Here are some behind-the-scenes pictures.
Katrina Kaif, another ambassador of the same company, has decided to skip this year owing to her shooting schedule of Anurag Basu's Jagga Jasoos.
Also See On HuffPost:
Cannes 2016
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Experiments in the Opportunities tab, feature, lets you evaluate the impact of the keyword and bid ideas that you see in your Opportunities tab.
"This new feature uses AdWords Campaign Experiments to run experiments on the keyword and bid ideas in your Opportunities tab. Experiments run on 50% of your AdWords traffic for thirty days, during which time you'll have the chance to compare your original campaign setup with your test setup. You can decide at any time whether you want to apply your experiment settings to 100% of your traffic. If you take no action after thirty days, your experimental changes will be applied to your campaign automatically," explains Google.
- Select keyword or bid ideas you want to test.
- Select the checkbox for "Evaluate this idea for up to 30 days."
- Click "Apply now."
Monitor experiment performance:
When your experiment is running, you'll be able to monitor your experiment performance from the Ideas page of the Opportunities tab.
You'll also be able to view performance statistics for individual keywords and bids on the Keywords tab when you segment by "Experiment."
For those who wanted to try ACE but didn't know what to test, this should help get you started. This's also a great feature for those who want to see a positive performance improvement before making changes to all of your traffic.
No matter how your new keywords and bids perform relative to your original setup, you'll leave your experiment with more knowledge than you had previously, which means every experiment is a good experiment.
The ability to run experiments in the Opportunities tab has already launched in some English-language accounts and will be available to all English-language accounts over the next few days.


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Posted by Tom Foremski - September 18, 2010
Everyone knows that Steve Jobs has banned porn and any sexual content from the iPad but is this a wise move?
I just started reading Nick Bilton's book "I live in the future & here's how it works" and the first chapter is about his investigation of the porn industry to see if there are any lessons to be applied to the media industry.
Every time a new technology has been introduced, way back to the printing press, sexual content has helped drive that technology and develop thriving business models that others have been able to adopt and prosper with.
Throughout the history of new media, from vernacular speech to movable type, to photography, to paperback books, to videotape, to cable and pay-TV, to "900" phone lines, to the French Minitel, to the Internet, to CD-ROMs and laser discs, pornography has shown technology the way. "Great art is always flanked by its dark sisters, blasphemy and pornography."(5) The same is true of the more mundane arts we call media. Where there is the Gutenberg Bible, there is also Rabelais; where the U.S. mails, dirty postcards; where the three-volume hardback novel, paperback pulp fiction; where HBO, Midnight Blue; where CompuServe, the Plain Brown Wrapper library.(6)
Pornography,(7) far from being an evil that the First Amendment must endure, is a positive good that encourages experimentation with new media. The First Amendment thus has not only intellectual, moral, political, and artistic value,(8) but practical and economic value as well. It urges consenting adults, uninhibited by censorship, to look for novel ways to use the new media and novel ways to make money out of the new uses. Therefore, while it may be politically impossible and socially unwise to encourage computer pornography, legislators should at least leave it alone and let the medium follow where pornography leads.
I see this issue as one of the most important issues facing not just the Internet but society in general.
We still haven't solved the problem of how to finance quality media.
It's the Gordian knot of our times, whoever solves it will be rich, but whoever solves it solves it for all of us, because we can all take advantage of it.
Story link | Subscribe free | Categories: A Top Story, MediaWatch, Saturday Post
The Holmes Report names Tom Foremski one of the top 25 Innovators of 2013.


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Steve Jobs quotes are famous and considered inspirational among entrepreneur and those who are struggling with their start-up, as Steve Jobs proved himself a great entreprise builder and marketer having a unique touch of humour in his sessions. He was affiliated with companies like Apple, Pixar, Walt Disney and possessed a long list of products that are produced as a result ... Read More »
Home > Tag Archives: business
Tag Archives: business
45 Entrepreneurship Quotes with Inspiration
Entrepreneurship demands a lot to be a good one in this field. Entrepreneur behave a bit different from other people and their working style doesn't match to one who works from 9 to 5. There are many institutes and universities which are not only offering great degrees in entrepreneurship program but also giving some start-up bootcamp, practice sessions and hubs ... Read More »


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Discussion in 'Transportation' started by Missyrose, Dec 22, 2012.
I just got $30 credits for each person on our late-January flights! Hope you can get credits too!
How did you get a credit? Does jet blue just credit you when the price drops on their own or did you have to call and ask for a credit since price dropped?
I just booked on jet blue 2 days ago...should have booked 3 days ago because it was cheaper then. LOL
Log in or Sign up
to hide this advert.
I also got a credit a couple of days ago. My $88 fare dropped to $70, so got a credit of $36 for our tickets. My return dropped too, but I bought those tickets with my Trueblue points. Looks like we'll be there about the same time.
Wow..that is great. Did you automatically get the credit or did you have to call them and ask for it?
You have to watch yourself and if you see a drop, then you have to call them. They will put the money in your travel bank and you can apply it to another ticket. You have one year to use it to purchase a ticket.
Didn't do it because of this thread, but checked today and my flight home went down $120!
Congrats, that's huge.
I dont have a flight planned or anything, but I did notice Jetblue has pretty cheap fares outta the DC area to FL during January. Makes me wanna just book something for the heck of it.
No luck - our flights are actually about $100 more now then when we booked them 3 weeks ago. Thanks for the heads up, though.
You have to call or email. We got $69 credit per ticket!
Sent from my iPad using DISBoards
Separate names with a comma.


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A band director with Fairfax County schools charged with soliciting a child online was corresponding with an undercover officer posing as a 14-year-old boy from his school, prosecutors said at a bond hearing Tuesday.
Michael K. Cook, 43, of Centreville, was arrested Aug. 31 after an online police sting. Cook has been placed on administrative leave from Fairfax's Robinson Secondary School, where he was in charge of the symphonic and marching bands.
Deputy Commonwealth's Attorney Katherine E. Stott said in court that Cook was "willing and eager" to meet his online correspondent, who he thought was a teenager, and that Cook wrote that he wanted to perform oral sex on the boy.
Patrick Woolley, an attorney for Scott, said his client was initially unaware of the purported victim's age and broke off contact once he learned it. He also said that police had not found any child pornography at Cook's home and that Cook was a "decorated member" of Robinson's faculty.
"Mr. Cook is not a sick individual. He is not a pedophile. He does not have multiple victims," Woolley said.
Authorities allege that Cook e-mailed the undercover officer, who was posing as a 14-year-old, on July 21 and asked the officer to send a picture to verify his age, according to an affidavit for a search warrant filed in Fairfax County Circuit Court.
According to the affidavit, Cook allegedly asked to perform a sex act on the boy in a follow-up e-mail and sent the officer a picture of himself.
In a subsequent instant-message exchange, Cook discussed meeting the purported victim at a specific time and location in Fairfax County, authorities wrote in the search warrant. On Tuesday, Stott said Cook had requested a meeting at a store, so he could see the boy before they went off together.
Woolley said Cook has never before had a significant offense and said he was recently elected president of the Virginia Band & Orchestra Directors Association. Woolley said Cook had been a teacher at Robinson for 12 years. Cook also led student tours to western Europe and plays tuba in the Fairfax Wind Symphony, according to a biography posted on a Robinson Band Web site.
A Fairfax County judge set Cook's bond at $10,000. Cook also cannot have contact with anyone under 18, use the Internet or meet with anyone from Robinson Secondary School.


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Wednesday, May 13, 2015
Too Kind, CMCC71
10 comments:
This is beautiful, done in your gorgeous signature style! Just lovely! And speaking of watermelon, we just got one and Cassidy ate almost the whole thing!ReplyDelete
love your layout and the little ribbon around the main panel - lovely birthday cardReplyDelete
Gorgeous embossed base, Sandy - perfect platform for all these lovely layers... this had me wishing for a watermelon stamp, too!!ReplyDelete
=] Michele
Love the pretty embossing and the gorgeous colors! Thanks for joining us at Seize the Birthday!ReplyDelete
This sure is light and pretty, love the DP you used!ReplyDelete
wow, stunning!ReplyDelete
wow, stunning!ReplyDelete
Sandy, you managed to make these bold colours soft and delicate. I absolutely love that floral stamp! :)ReplyDelete
Love the two-step flower, Sandy! Thanks so much for playing along at Seize The Birthday!ReplyDelete
Thanks so much for linking your fabulous card to our challenge at Seize the birthday!


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Re: Ketterman Family History & Genealogy
In reply to:
Re: Ketterman Family History & Genealogy
Lewis Ellingham 1/29/01
Hope this information helps.
Jacob Katterman
B. About 1711
BP in NY or England
M. 11 May 1746
D. Will made 16 Sept 1788
Anna Catarina Mueller/Miller (WIFE)
B. About 1724
3 Children
1.Maria Elisabetha born 9 Aug 1748 Berks Co. PA. married Simon Kersher
2. Michael born abour 1749- 1750 married Maria Elisabeth Batdorff
3. John or Johannes born about 1751- 1752
It appears that Jacob Kaderman is the Jacob Ketterman who came to Tulpehocken, Berks County, PA in 1728 from Schalire Valley, New York.
Jacob Kaderman "Will" Berks County, Tulpehocken Twp. 9/16/1788
In the Name of God Amen
This sixteenth day of September in the year of our Lord One thousand Seven hundred and Eighty eight, I Jacob Kaderman of Tulpohoccon Township in the County of Berks state of Pennsylvania yeoman, being at present Old and Infirm in Body, but of Sound disposing Mind, Memory and Understanding, thanks be to God, therefore unto Mind the Mortality of my Body, and knowing that it is appointed for all Men one (?) and to dye, do make and Ordain this my Last Will and Testament, that is to say Principally, and first of all, I recommend my Soul into the Hands of God who gave it, Hoping through the Merits or our Savior Jesus Christ to receive Remission of all my Sins, and an Happy Admission into the Regions of Bliss and Immortality, And as to my Body I recommend it to the Earth to be Buried in a Christian like and Decent Manner. And touching such Worldly Estate wherein it Hath Please God to Bless me in this Life, I give, devise and dispose of the same in the following Manner and Form.
Imprimus His is my Will and I do order that in the first place all my Just Debts and Funeral Charges be paid and Satisfied, as Soon as Conveniently may be after my decease
Item I give and Bequeath into my Beloved Wife Catharine
during her Natural Life, the Sum of Seventy Pounds Specio, her bed with Bedding Courtain and Bedstead, the Clock with the Case, the Kitchen Dresser and all the Kitchen Furniture and Wooden Ware, all the linen, and Flax, a Chest, one Table two Chairs, her Spinning Wheel, a Cow, three Sheeps, the Pipe Stove, the Corner Closed in the Chamber and all my Books, all which aforesaid Articles my Beloved Wife Catherine Shall have in her Use during her Natural Life, but not to Sell or distribute any of them, excepting the Cash she may lay out so much of the same for her Maintenance and Necessary as she may Pleases, but the rest shall be divided after her decease, as I Shall herein direct, and the same to be in Stead of her third part or demand of my Estate.
Item I give and Bequeath unto my sonJohn and his heirs the Clock with the Case and my large Bible which he or his Heirs is to receive after my said Beloved Wife her decease, and the same to be in full demand again at my Estate from my said Son John or his Heirs, because I have allowed unto my said son John his portions of my Personal Estate in my Plantation or Trade of Land which I have granted unto him in my Lifetime.
Item I give and Bequeath unto my Grand Daughter Elizabeth, a Child of my Son Michael deceased Ten P*** (pounds?) Specio, the Stuff for a Bed and Bed Stead, a Spinning Wheel and a Cow, which she is to have and receive before hand of my Estate Provided she has not received the same in my Lifetime.
Item It is my Will and I do order that the remainder of my Estate, that is to say what my Beloved Wife does not keep or what I have not bequeathed herein, Shall be Equally divided in two Shares, to wit, one share unto my daughter Elizabeth Wife of Simon Keeseker or her Heirs or Representatives and the other Share to my Grand Children , to wit John, Catharine, George, Elizabeth, Michael, Simon, and Margaret in equal Shares, as also the Articles, and Money which shall be in Possession after the decease of my Beloved Wife Shall likewise be divided in two Equal Shares amongst my aforesaid Daughter or her Heirs or Representatives and my aforesaid Grand Children, to wit the Children of son Michael deceased.
Item It is also my Will and I do Order that no Money or any other Article
which I have given unto my son Michael deceased, and unto my Son in law Simon Keesecker on behalf of his Wife before the date of this my Present last Will and Testament Shall be Accounted, but the same to be as an Equal Shares Between them.
Item It is further my Will and I do Order, that in Case it should Happenthat any of my aforesaid Grand Children should dye unmarried or without Heirs, that then in Such case the deceased Share Shall be Equally divided amongst the Survivors of my aforementioned Grand Children Share and Share alike and (and repeated) lastly I Nominate and Appoint my Son John and my Son in law Simon Keesecker to be Executors of this my last Will and Testament, hereby revoking disannulling and making Void all my former and other Wills and Testaments by me heretofore made, Ratifying and Confirming this and no other to be my Last Will and Testament, In Witness whereof, I the said Jacob Kaderman Have hereunto Set my Hands and Seal Dated the day and year first above written.
Signed, Sealed, and Published
Pronounced and Declared by the Jacob Katterman (as he signed it! ) said Testator as his last Will (Katterman as the administer wrote in 1802) and Testament in the Presence of us his Subscribers-----Henry Kisblinger - Adam Smith
1803- signed off by Samuel Catterman
List of Disbursments
Emanuel Shultz
Henry Kiplinger (probably same witness as above)
Peter Feather
Peter Seveguth and Andrew Zellen
Helfrich Kulb
Philip Wile
Joseph Lerch
Daniel Ludwig
Peter Frealy (could be Frailey, the registrar)
Finally Simon Keesecker signed off for Divers Causes on Dec 2, 1802 as executor witnessed by ? Bieber
1. Michael Kederman
B. about 1747/48 Probably Berks Co., PA.
D. Before 26th Sept 1781 Washington Co., MD.
P. Jacob Katterman
Maria Elizabeth Batdorf
B. 29 Nov 1746 Berks Co., PA.
P Hermanus Batdorf and maria Barbarra Anspach.
Seven Children
1. Johannes born 19 Nov 1768 Tulpehocken, Berks Co., PA. ,married Barbara ______.
2. Catharine born 22 Noc 1771 Tulpehocken, Berks Co., PA married Peter Bordner/Partner, died 1853
3. George born 9 Feb 1773 Tulpehocken, Berks Co., PA. married Eve Ridenour
4. Elizabeth born 9 July 1774 Tulpehocken, Berks Co., PA.
5.Anne Margaret born29 Feb 1776 Tulpehocken, Berks Co., PA.
6.Johannes Michael born 14 Apr 1778 Tulpehocken, Berks Co. PA. married Elizabeth Barbara Adam
7. Simon Samuel or Samuel Simon born about 1780 PA or MD. married Mary Hickman
Michael came to Washington County MD. about 1779 or 1780. He was farming in Maryland and he had corn in the field that was harvested after his death (per inventory of estate) The children all unde rage at the time of his death. In the Maryland Court Records Michael's last name is spelled Kederman, Kaderman and Kayderman, Keyderman. The distribution of his estate was 12 Feb 1788. Inventory of estate was dated 8 Dec. 1781. Next of kin was Jacob Potterman (this is his father Jacob Ketterman) Elizabeth Kederman (his wife)
A Catherine Householder paid the estate a bill she owed.
Typed as will and probate were written.
More Replies:
Re: Ketterman Family History & Genealogy
Lewis Ellingham 2/06/01
Re: Ketterman Family History & Genealogy
Re: Ketterman Family History & Genealogy
Lewis Ellingham 2/07/01
Re: Ketterman Family History & Genealogy
Re: Ketterman Family History & Genealogy
Dan 5/04/02
Re: Ketterman Family History & Genealogy
Lewis Ellingham 2/07/01
Re: Ketterman Family History & Genealogy
Carolyn backe 5/27/01
- Re: Ketterman Family History & Genealogy
- Re: Ketterman Family History & Genealogy
- Re: Ketterman Family History & Genealogy
- Re: Ketterman Family History & Genealogy
- Re: Ketterman Family History & Genealogy


text: Arstechnica.com NASA's next stop—Mars or the Moon? Enlarge / Mars or the Moon? It's a debate that has bedeviled NASA for decades.Aurich / Getty reader comments 7 Share this story HOUSTON—Possessed of slight build and modest height, John Grunsfeld is not an imposing man. But this appearance belies a brilliant mind and a considerable resume. A quarter-century ago, Grunsfeld worked as a physicist at the... #space #mars #nasa Tweet Source: arstechnica.com Read More


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17. January 2014
US warns merchants on methods used by Target hackers
"It continues to be frustrating pertaining to a quantity of merchants since it has been extremely difficult for nearly all firms to obtain information. three of your most well-liked titles for the malicious software contain BlackPOS, Dexter along with vSkimmer.
No. shop target disclosed the theft involving several 40 million payment card numbers and also the personal information involving 70 million consumers in a cyber attack which occurred over the holiday shopping season. This has certainly not been forthcoming."
BOSTON (Reuters) - The Particular U.S. "Now they may be armed with information plus they will go do one thing concerning it."
"It's the shame this record wasn't released the month ago," mentioned Dmitri Alperovitch, chief technologies officer of the cybersecurity firm CrowdStrike. government in Thursday provided merchants using info gleaned coming from its confidential investigation to the massive information breach at target Corp, in the move aimed at identifying as well as thwarting similar attacks in which might become ongoing.
U.S. Secret Service, iSIGHT Partners and the financial Sector information Sharing along with Analysis Center, an business safety group.
The document mentioned an advanced bit of software program dubbed the particular POSRAM Trojan, was adopted in the current attacks.
POSRAM succeeded in evading detection by simply anti-virus computer software if this infected the Windows-based point-of-sales terminals, according to the report.
John Watters, chief executive of the security intelligence firm iSIGHT Partners, that assisted draft the particular document released upon Thursday, said that the federal government decided to offer information to become able to retailers so they really could decide if their systems have been compromised by simply hackers.
The document titled "Indicators regarding Network Defenders" brings to mild a few regarding the 1st details gleaned from your government's highly secretive probes in to be able to the Goal breach along with other retail store hacks, which includes details helpful for detecting malicious applications that elude anti-virus software.
"The point associated with getting the technical artifacts out there is that individuals can go out there and examine their own
techniques as well as check if these people
have been compromised," said Watters, whose firm has assisted the actual Secret Services in its investigations of store breaches. three U.S. Neiman Marcus final week said that it too ended up being victim of a cyber attack, as well as sources have got advised Reuters in which no much less than 3 other well-known national stores have been attacked..
While the technology has been about for a total lot of years, its use has grown inside current a extended time as merchants have improved their security, making it more a hardship on hackers for you to obtain bank card information making use of some other approaches.
"We think there exists a strong industry for the progression of POS malware, along with evidence indicates there will be a developing demand," the report, obtained by simply Reuters, warned.
"This report ended up being generated so that we might have it to the hands associated with commercial entities so that they had details these people needed to protect themselves," iSIGHT Partners Senior Vice President Tiffany Jones informed Reuters.
The document had been ready through the Department regarding Homeland Security's National Cybersecurity along with Communications Integration Center, the U.S. Alperovitch associated with CrowdStrike declared your record contained fewer technical details than an article published upon Wednesday by security blogger Brian Krebs.
| Reuters
(Reporting simply by Jim Finkle; Editing Richard Valdmanis, Bernard Orr)
The Secret Service, which is heading up the particular investigations to the cyber attacks, provides declined to comment on which it's got learned or perhaps identify victims besides target and also Neiman Marcus.
The document noted that the underground industry for malicious software to attack point-of-sale, or perhaps POS, terminals has flourished throughout recent years. warns merchants on methods utilized by target hackers
POSRAM is an type regarding RAM scraper, or memory-parsing software, which in turn
enables cyber criminals for you to seize encrypted information through capturing it in the wedding it travels via the actual stay memory of your computer, where it seems throughout plain text.
A Department associated with Homeland security official mentioned your statement ended up being drafted to provide the particular industry "with relevant along with actionable technical indicators pertaining to network defense."
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After a three week layoff, the Oconee County Warriors finally got back on the playing field with a road victory over the Central Gwinnett Knights.
The Warriors played intimidating defense limiting the Knights to only 142 total yards.
The offense showed no signs of a long layoff. Quarterback Clay Calloway was 9 of 13 for 176 yards and one touchdown through the air. The game was not without bad news. On the fifth play of the game, Oconee's leading receiver, Cliff Barnette, went down with a serious ankle injury, which will put him out for the season.
Oconee scored first when Tony Taylor ran 15 yards to the end zone. Brad Bell got the second touchdown, then Callaway hit Gavin Williams for the third TD. Tristian Owusu-Yaw got a 12-yard interception return for a TD to make it 28-7 at the half.
The Tribe then went on for a 35-17 win, the 20th consecutive win over a region opponent.
Now coach Jeff Arnette's team is at home on Friday to host the Newton County Rams for the annual homecoming game.
Get there early for the game which kickoffs at 7:30 p.m. The 1971 team will be honored during pregame. This was Oconee's first regional championship team. If you were on this team or know someone who was be sure to remind them to show up.
Bridges is the stadium announcer for Warrior home games.
Cheerleader McCall Ginn poses with Gavin Williams, a wide receiver who scored two touchdowns.Terry Stephens/Special
T.J. Stephens was good on all four extra points.Terry Stephens/Special
Cheerleader Sara Tillman gives her mom, Gayle Tillman, a hug after the big victory.Terry Stephens/Special
Tristian Owusu-Yaw grabs an interception which he turned into a touchdown.Terry Stephens/Special
This article published in the Athens Banner-Herald on Wednesday, October 3, 2001.
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