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Below is the current list of National Youth Leadership Council (NCCL) members. To learn more about each of the members, just click on their name to see their brief biography as well as a Q&A about their experiences with the NCCL.
Hi! My name is Amy Bugwadia, and I'm a freshman at UCLA studying Cognitive Science as a Pre-Med student in the hopes of pursuing a career as a pediatrician. I was diagnosed with Ulcerative Colitis at the age of ten, in the midst of fifth grade. After years of silence, embarrassment, and resentment about my disease, my freshman year of high school, I met someone who was recently diagnosed with Ulcerative Colitis. Being able to share my story with him completely changed my perspective and showed me that our purpose as patients is to provide support to one another in a positive way. I got involved in the CCFA the following year as the 2014 Silicon Valley Honored Hero and started a Take Steps team called "Hope. Wish. Dream."
I'm excited to continue my involvement in IBD education, support, and advocacy efforts in the greater Los Angeles area. I'm currently a contributing writer to a blog for Connecting to Cure Crohn's and Colitis, a local LA-based non-profit focused on supporting IBD patients and their caregivers. I am blessed to have the opportunity to study my illness in a research setting as an Undergraduate Research Assistant in the UCLA Center for Digestive Diseases IBD Research Labs. I'm also the President and Co-Founder of a network of UCLA students afflicted with IBD.
As one of the newest members of the NCCL, I'm ecstatic to have the opportunity to continue these advocacy efforts with a group of passionate and resilient individuals. Having IBD has taught me the extent of my own strength as well as the strength of others around me. Being sick is not always a curse, and although it can be a true challenge, it has shown me that together, we can and will make a difference in the lives of many!
Hello! My name is Amy Dickeson and I am currently a senior at UC Berkeley studying Metabolic Biology in hopes of pursuing a career in medicine. I am ecstatic to have been on the council for two years now; it is incredibly fulfilling to be able to make an impact on students that have been affected by IBD, like me.
I was diagnosed with Crohn's the summer before my sophomore year of high school, though it took years of pain and suffering before I finally got answers. In 8th grade, I was misdiagnosed with an eating disorder after my weight and appetite began to severely drop, and I was failing to thrive. After a crippling year and a half of living with the pain and symptoms of an untreated disease, we turned to GI for answers, and I was finally diagnosed with Crohn's disease. Fortunately, my fantastic team of GI specialists were able to control my disease with oral medications, and I am proud to say I have been in remission ever since! Training my body to function again was a long and arduous process, but my whole experience taught me so much about myself and my goals in life, and I wouldn't trade these lessons for anything. I feel fortunate to have gained so much from my journey with Crohn's, and I hope to help others to do the same!
It took me years to be able to talk about my disease, and I had never met anyone going through what I was dealing with. When I came to Berkeley, however, I kept stumbling upon other IBD patients and I began to build up a small support system. It was so meaningful and fulfilling to meet others just like me; knowing that I wasn't in this alone was unbelievably powerful. I felt a sense of urgency to talk about it and be an advocate for my disease. I found the NCCL and immediately knew it was something I wanted and needed to do for myself. Words cannot describe how grateful I am to be working for such a fantastic organization and to have the ability to help college aged patients with IBD. I'm looking forward to seeing where this opportunity takes me and I'm excited for a fantastic year full of new opportunities and programs!
My name is Brian Ward. I am currently 21 and a junior at Gonzaga University in Spokane, Washington and am studying Biology and Philosophy on the pre-medicine track.
Growing up in Tacoma, Washington, I enjoyed an active lifestyle. In the summer of 2008, however, I couldn't seem to find my way away from the restroom. I was blessed with a quick diagnosis and was immediately put on steroids. After a few years, my doctors recognised malnutrition and after deliberation, transitioned me to a biologic. While my medical condition improved, it was still difficult for me to cope. Through CCFA, however, I was able to go to Camp Oasis, take part in Take Steps, and get to know many inspiring people. Since then, I've gone from being a camper to a counselor for Camp Oasis, and my Take Steps team has gone from four people to more than forty, and now, I am lucky enough to be a part of CCFA's NCCL!
I am currently on remission and doing well, but I still am passionate about Crohn's and Colitis. IBD affects too many people and I am proud to work with CCFA to help patient care, educate people about my disease, and to ultimately find a cure.
Hello! My name is Catherine Wicker and I am delighted to have been chosen to be an NCCL member.
I am a Sophmore at Texas State University, majoring in Public Administration with minors in Political Science Communications and Leadership Studies. In addition to the NCCL I am member of Gamma Phi Beta sorority, the Leadership Institute at Texas State, Dance Marathon and Christ Chapel.
I was diagnosed with ulcerative colitis on my second day of kindergarten after several months of my mom calling the doctors telling them she was sure it was more than a virus and it wasn't normal for a child to go to the bathroom 15 times a day or to lose that much blood. When I was 10 I had a total colectomy that was considered to be a cure. Unfortunately, I have continued to have intestinal issues and take medication daily. From day one of my diagnosis, my mom knew the best thing for me was to get involved with the CCFA so I had people that could support me while I lived with this illness. She was right; I am not sure where I would be today if she had not encouraged my participation.
Through the CCFA I have been involved with many different things including Camp Oasis, Team Challenge, Take Steps and IBD Day on the Hill four different times. I was honored to be recognized nationally by the CCFA in 2004 with the Local Hero Award. In 2005, I was delighted to be an Honored Hero for the South Texas Chapter and to attend their Winter Ball.
In 2007, I worked with three other friends and their parents to successfully pass the Texas Restroom Access Act. This Texas law allows individuals with medical conditions to have access to employee only restrooms. Watching then Governor Rick Perry sign the bill into law was one of the most thrilling moments of my life.
I am frequently asked why I have continued to take part in CCFA events for so many years. It's simple; I want every child to experience the joys of childhood without the worries of IBD and the treatments that go along with it. I believe it is important for people with chronic illnesses to have a voice, but especially those living with IBD. I am extremely grateful for the support from my friends in NCCL and I am excited to be on the board and to continue advocating and fundraising for the CCFA so that one day we will have a cure!
Hi! My name is Colette, and I am 20 years old. I am originally from Eagan, Minnesota and am a junior at Iowa State University. I am studying Animal Science/Pre-Veterinary with a hope of going to Veterinary School and becoming a Board Certified Veterinary Surgeon.
I was diagnosed with Ulcerative Colitis when I was 13. I was hospitalized with many symptoms including blood loss, extreme fatigue, fever, nausea, and pain. After many tests, I was referred to Minnesota Gastroenterology in St. Paul. I spent the next two years trying different oral medications, all of which failed in a matter of months. Finally, I was put on steroids and Remicade. Remicade gave me remission for almost 9 months, but then failed as well. My doctor suggested I go for a second opinion at the Mayo Clinic.
I have been treated at Mayo for the past 5 years, and the doctors and staff there are amazing! After going a full work up with new pathology reports, scopes, and tests, my doctor prescribed Humira. Similar to the Remicade, it failed after 10 months. I tried 6MP, Methotrexate, Cimzia, and various types of budesonide. Throughout the last 4 years I had been flaring off and on, but it was mostly tolerable. My senior year of highschool, I started a flare after recovering from mono. This flare was so bad that I missed almost 60 days of school throughout that year. I was contemplating surgery and was about to go through with a full colectomy, but a final set of scopes found inflammation in my small bowel and esophagus. My diagnosis changed to Crohn's Disease when I was 17, and I was put on prednisone to get me through the year. I have always struggled with prednisone and its side effects, and that year was the absolute worst. Luckily, my flare subsided before leaving for college.
My first year at ISU started out great! I was fitting in well, finding friends, and my health was not giving me an issue until October. Once October hit, I started to flare again and prednisone was the only thing that would keep me out of the hospital. Eventually hospitalization was necessary and I stayed for a week. Four more hospitalizations occurred in that first semester alone with this flare. Finally, my doctors started me on Entyvio in April. Luckily, this new drug has been life saving and *knock on wood* has put me in remission.
I am very honored and excited to serve on the NCCL, and I am so happy to finally meet other people like me. CCFA has taught me that I am not alone and that I have many resources and many forms of support available to me. I did not choose to get Crohn's but I wouldn't change my diagnosis for anything. Crohn's has shown me how much support I have from family, friends, and the IBD community. It has taught me self-discipline, responsibility, and compassion. I am so thankful for this opportunity and I cannot wait to see what this council can do to cure IBD!
I am a senior at Harvard University, concentrating in human regenerative and developmental biology pursuing a career in medicine/business, and participating in stem cell research in hopes of finding a cure for Crohn's. On my campus I am involved with the Pre-medical Society and the Athlete Medical Mentorship Program. I also participate in Women in Business, club tennis, club volleyball, Alpha Phi sorority, and writing gluten-free articles for the Crimson Crave newspaper. I am so excited to be an advocate of CCFA and NCCL on my campus.
I was diagnosed with Crohn's disease when I was ten years old after living with months of severe cramps and pain. At first, I was very scared. I had never heard of the disease, and I was worried about how it would affect my academic, athletic, and social life. With the help of my gastroenterologist, I was put in contact with my local CCFA chapter. My entire family has become very involved with CCFA at the local and national level. My father is on the national board as well as starting a local chapter of which he is currently president. We have fundraised through sponsoring local celebrity golf tournaments, deep-sea fishing tournaments, and corporate get togethers. Personally, I have organized teams for Take Steps Orlando since its inception there three years ago. I have managed a Team Challenge website for my mother who has run in 6 half-marathons and done one triathalon. I have attended my local conferences to learn more about new advances in treatments for IBD. I have met incredibly inspiring people at these events and am excited to see the support and awareness that can be generated to find a cure.
Throughout my journey with Crohn's, I have been on many different medications. I have had several flares, one occurring at the end of my first freshman semester that led to a bowel resection and the removal of 10 inches of my colon. Although I have never fully been in remission, I have continued to participate in sports at a high level, excel in school, and find time to have fun doing things I enjoy. Crohn's disease has not defined me: it is a part of me. It has given me the opportunity to be a mentor to others with IBD around me. I am extremely thankful that I am a member of the NCCL and that I get to work with an incredible group of people who understand me and are as passionate about finding a cure as I am.
Hello, my name is Emily Rund and I am a double major at Virginia Commonwealth University's School of the Arts in Richmond Virginia. I am currently a senior in the Photography and Film department with a concentration in film, as well as in the Kinetic Imaging department. I grew up in Carroll County Maryland.
I was diagnosed with Crohn's Disease at age four. Through trial and error I attempted most of the drugs on the market and eventually found a combination that has helped me live my life with minor gut issues. I have learned to look at the positives in my situation, the most important being my amazing support system. When I was nine years old I attended Camp Oasis as a camper and have gone every year since, now attending as a counselor. I have met my very best friends there and found my home away from home where I am comfortable to be myself with others just like me.
Through my involvement with Camp Oasis I have seen my close friends and campers living with IBD as best as they can. There are good days and bad days, but many of us have gone through more than any one person should endure. I am passionate about raising awareness for IBD, which I personally have worked on through making art but can now pursue further and more in depth as a council member. I am very excited to help find a cure!
I am a senior at Muhlenberg College, double majoring in Theatre and Media Communications. On campus, I am the Show Choir's Music Director, the Office of Information Technology's Resident Technician, and work as the Theatre Department's Student Master Carpenter. In addition, I mentor my high school's FIRST Robotics Team. I grew up in Blue Bell, PA, and am a proud member of the Philadelphia/Delaware Valley Chapter of the CCFA.
With the help of the CCFA, I have thrived through the most difficult period of my life. At age ten, I began to experience symptoms of extreme nausea, fatigue, and lost 20 pounds in a matter of weeks. The answer, Crohn's Disease, came about 6 months later following a battery of tests and hospital visits.
One of my first adventures following the diagnosis was CCFA's Camp Oasis. From my first day at camp, I realized it was a place to spend time without worry, and an opportunity to make meaningful, lasting friendships with people I would have never met otherwise. Summer 2016 was my 11th summer at Camp Oasis. It is an amazing experience to return again as a counselor. My goal is to be able to give back to others what Camp Oasis and the CCFA have given me. I also captain Team Tiffany for the Take Steps Walk in order to encourage others to fight for a cure.
During my time with the CCFA, I have become an advocate for adults and children living with Crohn's and UC, serving as the 2007 Youth Ambassador, the 2013 Honored Hero, and now as a member of the College Council. Having an outlet to help deal with a potentially debilitating disease while serving others is a tremendous honor. The CCFA has been there for me since my diagnosis, helping me along the path of turning a challenge into an opportunity.
I love sharing my story and speaking with others so please reach out if you have any questions or just want to talk!
My name is Grady Stewart, and I am 19 years old. I am currently a Mass Communication major, and a Digital Media Arts minor at Louisiana State University. Geaux Tigers! In the future, I hope to work in the media and continue to advocate for the IBD community.This is my first year on the council, and I am extremely honored to have been given the opportunity to make a difference in the lives of other patients battling IBD.
As a child, I grew up in New Orleans, Louisiana and was raised on some of the best food in the world. My life has been a series of happy adventures. I went to an immersion school, and became fluent in French. After Hurricane Katrina, I realized that I could preserve the memories that had been washed away by the storm through art. I turned to writing, and then to film to capture, create, and honor the stories that define life. For me, media, filmmaking and writing is a way to communicate in a universal language, experiment with infinite ideas, and exceed the limitations of reality. Around the same time, I started performing circus arts, and ever since I've been hooked on performing! I've juggled on top of mountains, and unicycled in 8-mile Mardi Gras parades. I've even gone hang gliding in the French Alps! I was fortunate to live a healthy, IBD-free, childhood.
In late 2015, I was diagnosed with Ulcerative Colitis. I tried out several different medications before recently settling on Remicade. I am hopeful it will do the trick. Living with IBD has taught me to better manage my health, value every moment, and be positive.While my diagnosis has been challenging, it has also motivated me to get involved and advocate in my community. I organized a circus troupe team to participate in Take Steps, and served as the photographer for another local walk. Today, I frequently volunteer at the local animal shelter, and I am constantly looking for new ways to give back to the community. Most importantly, I know that I am stronger than ever.
My name is Jack and I am a junior at the University of Denver. I am majoring in Strategic Communications with a Marketing minor. I am a Brother of Theta Chi Fraternity.
Growing up, I was very healthy and often participated in two sports in which the seasons overlapped. In high school I participated in soccer, hockey and tennis. I was also involved with Campus Ministry. I am the youngest of three siblings and originally from Minnesota.
I was diagnosed with Ulcerative Colitis at the age of 15 during my sophomore year of high school. I ended up becoming very sick during hockey tryouts and failed to make the team. It took me awhile to become comfortable talking about my UC but have come to realize that it has made me a stronger person. I know by sharing my experience with others it may help them understand that they are not alone and that with the proper support and medication they too can lead a normal life. Personally, I have found relief in Remicade after having tried many different kinds of oral medications.
I interned at the Minnesota Dakota Chapter during the summer of 2014. The level of enthusiasm and passion for CCFA in that office is contiguous. They were the ones who introduced and encouraged me to apply to the council. I am very excited to bring CCFA to my campus and raise more awareness.
My name is Kajal Patel and I am currently a junior at Rutgers University studying Biological Sciences in pursuit of a career in the medical field.
I was diagnosed with ulcerative colitis when I was 12 years old. Fortunately, after the usual symptoms appeared, my pediatrician referred me to a gastroenterologist. I was immediately hospitalized and put on oral medications. Once I became well enough, I attended seminars on IBD with my parents, and my curiosity in the medical field only grew. High school was a difficult time, as I went through different medications and multiple flares. However, my education has always been a top priority and I ended up graduating as the class valedictorian. Although I am relatively stable and have been taking Humira and other oral medications for the past few years, I recently had a surgery for a fistula.
Along with family and friends, I have participated in walks for Crohn's and Colitis. I also started an organization called the IBD and IBS Association at Rutgers. The purpose of this organization is to improve the quality of life of students affected by either IBD or IBS, raise money to support basic and clinical research, offer educational programs to all students, and create support groups to help people cope with their condition at Rutgers.
I want others to accept their illness as well and not let their illness become their only identity but have their illness become part of their identity. When I was younger, I only saw the effects the illness had on me, but I never realized it was only a small fraction of my identity. I am so much more than my illness and I want others to see that for themselves. I would not be where I am today without the support and love I have received from family, friends, and most importantly the IBD community. I am so honored to be working with so many inspirational people in the NCCL. We stand together for the battle and we will succeed in finding a cure.
Hi, my name is Kalee Eichelberger and I'm a Senior at the University of Florida. I am studying Biology as a premedical student and conduct research in a pediatric gastroenterology lab investigating different pathways scientist can utilize for IBD treatment. I have been very influenced by the role medicine and health professionals have played in my life. The relationships I have formed at my school's Disability Resource Center have inspired my minor in Disabilities in Society and the role diet has played in my IBD health has lead my college career.
Receiving a diagnosis for me was very challenging. I started having gastrointestinal problems from about the age of middle school, was scoped, and diagnosed with Celiac Disease. From then on all my GI problems were attributed to the Celiac sprue I had developed throughout the years. As time went on I was getting sicker and I was diagnosed with juvenile rheumatoid arthritis, vasculitis, and POTS. Treatment after treatment was failing and I started having the worse stomach pains I had ever experienced throughout high school. My junior year I was finally diagnosed with Crohn's Disease after another flare put me in the hospital.
Achieving remission has been really challenging and painful but joining a CCFA support group helped me become more open about my disease and connect with others affected by IBD. Through the support group I was able to participate in Take Steps and find out about the NCCL. Because it took me so long to receive the diagnosis and care I needed, advocacy and education is something I am very passionate about. I now co-facilitate the Gainesville chapter support group, am an active Power of Two mentor, and help organize Take Steps in Gainesville. With CCFA's support, I've been able to establish a student group on campus, raise awareness, and help push for a cure.
Hi! My name is Kira Nathan and I am a senior at Oberlin College, in Oberlin OH. I grew up in upstate New York but my family has bopped around a few times, until finally settling down in Richmond VA. In Ohio I study biology and history with the plan to go to medical school following college. I have been a part of the council for three awesome years and have loved every minute of it!
I was diagnosed with Crohn's disease when I was 10 years old and luckily found medication early on that kept my disease under control. While my Crohn's disease has given me challenges, I can't imagine growing up any other way as it has inspired me to pursue medicine, given me immense confidence and independence. Plus, once I began to meet other people with IBD it inspired me to be more vocal about Crohn's disease and Ulcerative Colitis whether within my own community, or outside of it.
As a result, I found the NCCL and the incredible community the council members create. They give so much support and advice that has helped me get the best out of college and whatever comes next. As a part of the council I have loved seeing the real changes a group of college students has made whether within or outside of the IBD community!
Hi! My name is Mary Frances Ierlan. I am currently a sophomore at Marquette University in Milwaukee, WI studying Public Relations.
At Marquette I am a campus tour guide as well as work in the Athletics Communications office. I also write for an online blog called The Odyssey and am in the Public Relations Mentor Program.
I was diagnosed with Ulcerative Colitis in 2011 at the age of 13. I had been in pain and had felt very fatigued for a few weeks before I told my parents. I was very scared when I was first diagnosed, by all the names of the medications and different diets and because I had never heard of Crohn's or UC before. A year later I had a total colectomy and lived with an ostomy bag for the first 3 months of high school. After the reversal surgery I felt the best I had in a while. I was not on many medications and I slowly felt better than I had in a long time. The summer after my senior year of high school, I became symptomatic again and was told that I had Crohn's Disease. I am now on medication to handle the disease.
Going to school 800 miles from home has been a challenge at times, but has made me become a better advocate for myself as a patient. I have learned how to take care of myself and how to eat right with a meal plan!
I have been involved with my local chapter of the CCFA through the Take Steps walks. As I have grown older, I have come to accept my disease and become more comfortable speaking about it with others.
The NCCL is a great way to meet others dealing with these diseases. It allows me to be an advocate and to speak about a cause that I am very passionate about.
Hi! My name is Matthew Herrera, and I am currently a senior studying Biological Engineering at Louisiana State University, with hopes of pursuing a career in medicine and making a difference in the lives of people suffering from IBD. I was born and raised in Baton Rouge, Louisiana and have lived there my whole life. On campus, I am a member of the drumline in the LSU Tiger Band, as well as the Biological Engineering Student Organization.
I was diagnosed with Ulcerative Colitis when I was five years old and was immediately treated heavily for the disease. I had minor complications with the disease while growing up, but was lucky enough to keep it under control for most of my younger life. High school was the hardest time for me with my health, having a couple major flare ups that hospitalized me for a few weeks. After a flare up during the first week of my senior year, I changed medications and have been in remission ever since.
As a patient, talking about IBD can be very challenging. I have constantly dealt with the embarrassing issues that are naturally associated with my disease, especially since a chronic illness can inadvertently affect every aspect of life. Living with Ulcerative Colitis is all I have ever known, so I've learned how to live with my illness and how to succeed in many aspects of life. However, I believe it is important to reach out and open up about living with an IBD, and I hope to be a resource for those living with a chronic illness.
This is my first year as a member of the NCCL, and I am looking forward to making a difference in the IBD community. The CCFA has given me the opportunity to help increase awareness, education, and support for patients suffering from these diseases, and I hope to help increase focus in my area while doing so. I am extremely grateful to be working with so many talented and inspirational people who are all dedicated to curing and treating inflammatory bowel disease.
My name is Missy O'Doherty, and I am currently a senior at the University of Denver. I grew up in San Diego, California, with two amazing parents and a wonderful sister, where I discovered my love for music and the practice of medicine. I am currently studying biological sciences and music, with a dream of going to medical school.
I was diagnosed with Ulcerative Colitis the summer after I turned 11 years old. For the first three years, I went through almost every medication that could be given to a child for IBD with no relief. I was in an out of the hospital every other month during this time. Finally by my Freshmen year of high school, I was put on an infusion that finally put me into a remission. It was the first time I felt normal since my diagnosis, and kept me healthy all throughout high school. Although I have been sick since then, I have been lucky enough to go to college, compete in triathlons, and help CCFA raise awareness and much needed funds for Crohn's and Colitis since. It's a daily struggle, but the support you gain from CCFA and meeting others with this disease is astounding. I am lucky to have found CCFA and met so many inspiring and encouraging individuals through all the amazing programs they have offered me.
It has certainly been a difficult almost 10 years, but these past years have been an incredible journey. I have grown and learned so much despite the adversity I have faced as a result of my diagnosis and am thankful that this disease has helped me grow into this strong and successful individual. I look forward to making a difference through the National Council of College Leaders, for the 1.6 million Americans and many many college students living with these incurable illnesses everyday, who may not be as lucky as myself. I also hope to become an integral part of what the CCFA mission is about, and be a great role model by sharing it with all those whom struggle daily. Support and a great attitude is really what its all about.
I am a senior at the University of Missouri- Columbia. I am the middle child in my family with one older and one younger sister.
I was diagnosed with Crohn's Disease when I was ten. At first my disease responded well to oral medications and I was growing well and in remission for several years. During my last years of high school that changed. I recently had an intestinal resection and I am doing pretty well with the help of Humira.
When I was first diagnosed no one in my family had even heard of Crohn's Disease. Man, we have come a long way since then! My first experience with anyone else who had Crohn's Disease was through CCFA. Right away we became involved with the Take Steps walks every year. But then something changed that fueled my interest in helping advance research and awareness for Crohn's Disease...my younger sister, Anabel, was also diagnosed with severe Crohn's Disease.
I am no longer uncomfortable speaking about my disease, the more people know the more progress we can make. I participate in CCFA's events, camps and fundraisers and have organized two successful 5K's in the small town that I am from. When I first learned of the council a couple years ago I knew I wanted to be involved and now here I am. To set an example for my sister and any other young people that I can affect I will continue to live by the motto that says 'I have Crohns', Crohn's doesn't have me.
My name is Rachel and I am honored to be a member of the NCCL. I am a freshman at the University of Maryland, College Park studying community health. On campus, I am an ambassador for my university's Honors College and am involved at Hillel.
I was diagnosed with Crohn's disease at age 7 in April 2005 after experiencing many severe symptoms of IBD. I spent the next few years constantly in and out of the hospital, missing the majority of 2nd and 3rd grade as well as many months of middle school. During this time, I tried a myriad of treatments such as steroids, Remicade, Humira, 6MP, Methotrexate, and more, none of which were able to put me into remission. I lost a substantial amount of weight, failed to continue growing, and had difficulty eating, so I received tube feedings through a nasogastric tube for a year and a half and then through a G-tube for more than 3 years.
The summer before 7th grade I had my large intestine removed and finally found some relief after years of struggling with Crohn's. Since then, I have had a few other surgeries and am currently on Entyvio and Stelara.
In 2015, I finally attended CCFA's Camp Oasis as an LIT. It was a truly amazing experience that introduced me to many outstanding individuals with IBD. It showed me that I am not alone. This past year I did my first Take Steps walk, and in the future I look forward to becoming more involved with CCFA and the IBD community. I am very excited to reach others with IBD, raise awareness, and work with the passionate members of the NCCL.
My name is Sarah Kate DelaCourt and I am currently a freshman at the University of North Carolina at Wilmington majoring in nursing with a minor in chemistry. I am so excited to be a member of the NCCL, and I am honored to be able to advocate for other students with IBD and to make an impact on their lives.
I was diagnosed with Ulcerative Colitis when I was fifteen, about halfway through my sophomore year of high school. I had been sick for several months, and the symptoms were getting more severe. I was admitted into the hospital in the beginning of December and had a colonoscopy done which revealed severe Ulcerative Colitis. I was relieved that we finally had a diagnosis, but I was fearful for what the future would hold. I was immediately put on oral medications, but sadly had an allergic reaction to the first colitis drug we tried. I was then put on Methotrexate and high doses of steroids which was enough to put me into remission. After spending Christmas and New Years in the hospital, I finally was able to return home and adjust to the new normal. I was in remission for about a year before I relapsed and, after discussing the options with my doctor, I was put on Remicade. Fortunately, it has kept me in remission for a year and a half now, and I am so thankful for my infusion clinic! Even through my diagnosis in high school and relapsing once, I was still able to play two varsity sports and graduate at the top of my class. I am also thankful to have been blessed with such a supportive family and amazing nurses and doctors who have been with me every step of the way. I cannot wait to be an advocate on my campus, and start spreading awareness about IBD.
Having IBD has no doubt been one of the hardest things in my life, but it has also taught me so much and given me the overwhelming desire to want to help others also struggling with it. Through my diagnosis, I have decided to become a gastroenterology nurse to hopefully shine a light in the lives of IBD patients who might feel like all hope is lost. Beyond anything else, I want people to know that they are not alone, and that there are resources to help them fight this battle! Coming into college I knew that I wanted to make an impact on the IBD world around me, so I started a Take Steps team in my own city. When I was diagnosed as a high schooler I did not know anyone else with either Crohn's or Colitis, so sometimes I felt like I was all alone in my journey. Now, as a member of the NCCL, I want to be able to reach every student I possibly can with the reassurance that they are not alone in their disease. IBD is a lifelong struggle, but it most definitely does not have to define your life!
My name is Scott Gringauz and I am currently a sophomore at the University of Colorado Boulder. I am a member of The Presidents Leadership Class where the focus is to develop ethical and extraordinary leaders in society.
I am a business major in the Leeds Scholars Program with an emphasis in accounting. My goal is to obtain a Masters in Accounting in order to become a CPA.
Growing up in South Florida I loved spending time outdoors. I played everything from flag football to soccer but at the age of nine it became apparent that something was wrong. My growth was clearly stunted, I was not eating, I was gray in color and I was extremely lethargic. My parents had taken me to doctors but they overlooked my bad blood work. Eight months later I was very weak. Horrible lab results were the first factor and hint that this was not good. My GI doctor performed an endoscopy and a colonoscopy and determined that I had Crohn's disease. Hospital stays, lots of medicines with side effects, multiple procedures, many doctor visits made it difficult to be a normal kid. Fast forward four years and my Crohn's disease had progressed to the point of affecting my daily life. Initially my parents supplemented my milder meds with natural remedies, but after months of no results my doctors decided to put me on Remicade. Just one week after my first infusion I was already feeling like my old self. Finally, I could participate in all the activities I loved; especially playing sports. I am 18 now and have been in remission for five years.
Six months after diagnosis at age nine my family decided to get involved in the Crohn's and Colitis Foundation. I began by creating my own Take Steps Walk Team and then decided to share my journey in front of others at two fundraising events and, by sharing my camp experience in a video to raise funds for Camp Oasis My favorite CCFA experience is attending Camp Oasis first as a camper and then, as a LIT. I loved Camp Oasis because I was able to meet other kids who had similar journeys to mine. Now, I am on the NCCL and I hope to continue my lifelong commitment to making a difference within the CCFA community!
My name is Ty Redler and I currently attend the University of Florida. Before I was diagnosed with Crohn's Disease in 2008 I was a very active kid, I had a scholarship to play soccer in high school and I was also one of the top jazz baritone sax players in the state of Florida. Nine months prior to my diagnosis started me on the path that I did not know where it was going to go. On August 28, 2008 my life as I knew it was going to be changed for the rest of my life but I couldn't fathom this.
The day after I was diagnosed I started to research how I could possibly help these horrible diseases. I found CCFA and asked them how I could help. A few months later when I was healthy enough to leave my house they asked me to be the honored hero for take steps and team challenge and give speeches to recruit people for the events. After giving the speeches I met a girl who told me that I had to go to Camp Oasis.
When I got to college I knew I needed to help make an impact in the world so I started to look a position in a lab to join and perform genetic research. After starting in my first lab I was very persistent with questions, asking to take part of some experiments which in turn allowed me to take on my own projects and network with other researchers. Now after doing research for 4 years I can say that research is the building blocks to discovery, with discovery we will find a cure in the near future. After joining my lab I heard about the National Council of Collegiate leaders to help be an advocate for college students and patients across America so they can have equal rights to healthcare and to not be discriminated in any sense.
Although in August of 2008 my life was completely changed, it was changed in a positive way. I learned that we all are different and even though I have a condition this condition will not control my life; I will.
I am a sophomore at Saint Louis University studying accounting and finance with the goal of studying financial law post-graduation.
I was diagnosed with Crohn's disease at 9 years old. I was embarrassed and wanted more than anything just to be a normal kid. For years, no one outside my family knew I had it. Eventually in 8th grade I decided I wanted to make an impact in the IBD community. I went from no one knowing to speaking to my entire grade and sharing my story. I founded my own fundraiser to benefit CCFA which is now an annual event, attended Camp Oasis (and stayed) after many years of signing up and being too nervous to actually go, I participate in Take Steps yearly as the Team Captain of my team, am involved in ImproveCareNow as the Recruitment Lead of the Patient Advisory Council, am a part of the Central-Ohio Take Steps Walk Committee, and now a member of the NCCL.
Though IBD has presented me with many struggles, I am grateful for its impact on my life and all I have gained from battling the disease. It has been empowering to work with CCFA, alongside friends, to end the fight against IBD.


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|Oh, Mr. Brown, you are a saint. You have a lovely look of kindness about you. What I wouldn't give for a man like you, Mr. Brown, in my hour of need.
|~ Mrs. Selma Thaddeus Quickly
Selma Quickly is a thrice-widow who doesn't like it when people use bad behavior and the secondary antagonist of Nancy McPhee.
At first, she seems to be a beautiful, sassy woman, but is cruel and dislikes children.
She was portrayed by Celia Imrie.
Mrs. Quickly looks like she's beautiful and nice but is cruel and harsh which was shown during her wedding ceremony with Cedric Brown. It was also shown that she dislikes children.
Role in the Film
Mrs. Quickly was first shown when she came over to the Brown Family house to become Cedric Brown's wife-to-be. Cedric was trying to protect her from his children's pranks but angrily leaves.
Later, Cedric's children arrive at her house and explain everything to her including their Aunt Adelaide's wealth. She comes back to the Brown house and agrees to be Cedric's wife.
At the wedding, Selma shows the the children that she's cruel and conniving when she breaks Aggie's rattle. During the wedding, Mrs. Quickly tells Simon Brown to behave even though Aggie is telling him beehive.
Then, the children pretend that there are bees and she asks if there are any bees until Cedric Brown replies yes and tips her hat.
Then, a fight is began by throwing wedding cake at everyone. Then, Selma realizes that half of her hair is gone and sees Sebastian Brown and Chrissie Brown playing with it.
She angrily grabs them but Cerdic pulls them away from her. She angrily leaves and it's unknown what happens to her at the very end.
- Cedric Brown (ex-fiancé): Selma Quickly had a likely to Cedric Brown but not when he was trying to protect her from his children's pranks. She later liked him again after his children explained everything to her. During the wedding, Cedric started disliking Selma when he smacked her hat after saying there was a bee. Before Selma could hurt Sebastian and Chrissie, Cedric angrily pulls them away from her. Selma breaks up with Cedric and leaves.
- Aunt Adelaide: Selma seemed pretty interested in Aunt Adelaide's wealth when the children told her about it. When she first met Aunt Adelaide, she bowed to her and it seems she has a liking to Aunt Adelaide and was shocked when she accidentally threw cake in Aunt Adelaide, but when her wedding was ruined, she angrily tells Cedric, that she don't care how money gave him the "Old hag" (refering to aunt Adelaide).
- Simon Brown: Selma doesn't seem to like Simon during the wedding. When she takes Aggie's rattle, Simon tries to take it from her but pulls it away. While walking on the aisle, she told Simon to behave while Aggie was telling him beehive. It maybe said that Selma and Simon are enemies to each other.
- Mrs. Quickly, in a way to very similar to Coco LaBouche from Rugrats In Paris, as they are both mean women, lie and hate kids.

subset: commoncrawl


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GALVESTON — Brandon Eubanks isn't quite finished with his studies at ITT Technical Institute but knows if he wants to land a good-paying job when he graduates, it doesn't hurt to get a foot in the workforce door.
That's why the 25-year-old League City resident and his friend Steven Walsh, 26, of Webster were stopping by every booth at last week's Oceans of Opportunity Job Fair. The two were looking for internships in the information technology fields.
They have at least 7,000 reasons to do so. That is how many new jobs in information technology were created in Texas in the past year, making it one of the fastest growing segments of the workforce.
So as the friends walked by the NASA-Johnson Space Center booth at the job fair in Galveston, they noticed a call for interns to work on the space program.
"We have a couple of professors who work for NASA who told us to try and get our foot in the door there and that this would be a good place to look for an internship," Eubanks said. "Mainly (I'm here) looking to try and get a job to get IT experience."
And it's a good time to be looking for a new job.
The latest state employment figures show that more than 322,000 jobs were added in Texas in the past year.
Most came in the trade, transportation and utilities fields where 77,000 jobs were created between January 2013 and January 2014, according to figures from Texas Workforce Commission.
The oil and gas industry added another 15,800 jobs in the past year, according to January figures, the most recent numbers.
All those new jobs helped push the state's unemployment figures to 5.7 percent, the lowest it has been since November 2008, according to the commission's figures.
That bodes well for James Patterson of Texas Worksource, the state agency charged with connecting employers with potential employees. It also is why the Oceans of Opportunity job fair was bigger this year than in years past.
More than 100 employers signed up to participate and more than 500 job-seekers came out with résumés in hand at the Galveston Island Convention Center at The San Luis Resort.
"I wanted to make this more of a countywide thing, so I reached out to companies further north (including Houston)," Patterson said. "I am trying to make this more of a regional thing. We decided to make this bigger, to bring in different companies."
The Oceans of Opportunity job fair was started soon after Hurricane Ike struck. Now that the economy has recovered and in many places is expanding, the job fair has changed focus.
"Really (the job market) is very good," Patterson said. "It's cooled a little bit compared to previous years, but we were on fire then. With all the building (within the regional petrochemical facilities), to be honest there is more of a skill gap than a shortage of jobs."
That's why the job fair teamed with the county's two community colleges, Galveston College and College of the Mainland, Patterson said, to be able to better prepare the next group of workers.
"We have order writers for (Texas Worksource) who are putting the jobs out there, and they just can't keep up," he said. "A part of the problem is as these facilities and buildings go up, you need jobs that require certifications. So (workers) need to go to the community colleges to get that training."


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Black patients with hemophilia A (factor VIII deficiency) are twice as likely as white patients to produce inhibitors against factor VIII proteins given as replacement therapy. There are six wild-type factor VIII proteins, designated H1 through H6, but only two (H1 and H2) match the recombinant factor VIII products used clinically. H1 and H2 are found in all racial groups and are the only factor VIII proteins found in the white population to date. H3, H4, and H5 have been found only in blacks. We hypothesized that mismatched factor VIII transfusions contribute to the high incidence of inhibitors among black patients.
We sequenced the factor VIII gene (F8) in black patients with hemophilia A to identify causative mutations and the background haplotypes on which they reside. Results from previous Bethesda assays and information on the baseline severity of hemophilia, age at enrollment, and biologic relationships among study patients were obtained from review of the patients' medical charts. We used multivariable logistic regression to control for these potential confounders while testing for associations between F8 haplotype and the development of inhibitors.
Of the 78 black patients with hemophilia enrolled, 24% had an H3 or H4 background haplotype. The prevalence of inhibitors was higher among patients with either of these haplotypes than among patients with haplotype H1 or H2 (odds ratio, 3.6; 95% confidence interval, 1.1 to 12.3; P = 0.04), despite a similar spectrum of hemophilic mutations and degree of severity of illness in these two subgroups.
These preliminary results suggest that mismatched factor VIII replacement therapy may be a risk factor for the development of anti–factor VIII alloantibodies.
Infusion of plasma-derived or recombinant factor VIII is the standard method of arresting hemorrhage in patients with hemophilia A (factor VIII deficiency). Alloantibodies that neutralize the activity of the replacement molecules develop in approximately 20 to 25% of patients,1,2 however, and the treatment of patients who have these inhibitors can be costly.
The risk of formation of an inhibitor is influenced by the type of mutation in the factor VIII gene (F8).3-7 Large deletions, inversions, and nonsense mutations are associated with the highest risk, probably because the recipient's immune system recognizes the normal factor VIII replacement protein as a foreign molecule. The type of mutation also is associated with the severity of hemophilia A. Thus, the association between the type of mutation and the development of inhibitors may be confounded by variables related to the severity of illness, such as age at the first infusion of therapy8 or the cumulative number of days of replacement therapy.9
The prevalence of factor VIII inhibitors in black patients is about twice that in white patients.9-16 The mechanisms that account for this difference are unknown. In a study of F8 in 137 healthy, unrelated people from seven groups of diverse geographic origins, we identified four nonsynonymous single-nucleotide polymorphisms (SNPs) — G1679A (encoding the amino acid substitution of histidine for arginine at position 484 [R484H]), A2554G (encoding the substitution of glycine for arginine [R776G]), C3951G (encoding the substitution of glutamic acid for aspartic acid [D1241E]), and A6940G (encoding the substitution of valine for methionine [M2238V])17 — whose haplotypes (allelic combinations) encode six distinct factor VIII proteins, which we designated H1 through H6.18 Two of these proteins (H1 and H2) were found in all seven groups, but three (H3, H4, and H5) were found only in black people (16 subjects) and one (H6) was found only in Chinese people (10 subjects). (See Supplementary Appendix A, available with the full text of this article at NEJM. org, and Fig. 1.) The prevalence rates of H1 and H2 were 0.93 and 0.07, respectively, among whites in this study (86 subjects) and 0.35 and 0.37 among blacks. The prevalence rates of H3, H4, and H5 were 0.22, 0.04, and 0.01, respectively, among blacks. Kogenate (Bayer) and Recombinate (Baxter), the two full-length recombinant factor VIII products currently approved for use in persons with hemophilia A, correspond to the amino acid sequences of H1 and H2, respectively.21-24 In principle, therefore, one in four blacks with hemophilia A who require replacement therapy with recombinant factor VIII will receive products that differ from their own factor VIII protein at one or two residues, in addition to having amino acid differences attributable to the specific F8 mutation. Plasma-derived factor VIII is also a source of exposure to H1 and H2, because most blood donors are white.25-28
Alloimmunization against factor VIII can occur in white patients with F8 missense mutations29 that change only a single amino acid residue in the factor VIII protein.18 However, differences between replacement factor VIII and the patient's factor VIII at residues encoded by nonsynonymous SNPs, whose alleles do not cause hemophilia, have not been investigated as risk factors for the development of inhibitors. We hypothesized that the higher prevalence of inhibitors in black patients may be due in part to the greater degree of population-level variation that exists in their factor VIII amino acid sequence and the resultant increased probability of a mismatch with replacement factor VIII proteins.
Between November 13, 2003, and April 6, 2006, we invited black patients with hemophilia A undergoing treatment at any of four Federal Region IV South Hemophilia Treatment Centers to participate in this study during scheduled annual visits.30 The participating centers were Emory University, Atlanta; the University of Alabama at Birmingham, Birmingham; the Medical College of Georgia, Augusta; and the University of Mississippi Medical Center, Jackson. Each of the 78 enrolled patients provided a blood sample. Patients or their parents or legal guardians gave written informed consent for participation in the study. The institutional review boards of each participating center approved the protocol.
A short, standardized survey was administered to all patients by each center. Information concerning self-reported race, age, baseline severity of hemophilia, results of previous testing for inhibitors, and other affected family members was obtained from medical records and interviews with patients by the nurses involved with enrollment. To take into account nonindependence of subjects due to family relationships, all patients with affected relatives were asked whether any relative was being treated at any of the participating centers and thus might be enrolled in this study.
Data on inhibitors were obtained from reviews of the medical charts by the nurses. To identify inhibitors, the participating centers used the Bethesda assay31 with a Nijmegen modification32 known to improve its specificity near the cutoff for a positive test result, which was 0.6 Bethesda unit per milliliter. In general, patients were screened for inhibitors during their annual evaluations. Baseline severity of hemophilia was defined according to the initial level (in units per milliliter) of factor VIII activity as a percentage of normal. Mild hemophilia corresponded to a baseline level of factor VIII greater than 5% but less than 40% of normal, moderate hemophilia to a baseline level equal to or greater than 1% but no greater than 5% of normal, and severe hemophilia to a baseline level less than 1% of normal.33 To measure factor VIII, each center used factor VIII–deficient plasma and assessment of the activated partial-thromboplastin time.
All known functional regions of F8, including 1194 bp of the contiguous promoter sequence, all 26 exons, 50 to 100 bp of each junctional-intronic segment, and 309 bp of flanking 3′-genomic DNA, were amplified by the polymerase chain reaction (PCR) and sequenced as described by Viel et al.17 Sequencing was performed to genotype the known nonsynonymous SNPs, discover new nonsynonymous SNPs, and identify the noninversion hemophilia-causing mutations. The sequencing chromatograms were processed with Phred software (www.phrap.org)34,35 and SAS software programs written in-house17 and were then reviewed manually. Given that males have only one X chromosome, patients with hemophilia are hemizygous for F8, and thus haplotypes were constructed as a simple combination of the patient's nonsynonymous SNP alleles.
To identify inversions in introns 1 and 22, we used genomic DNA samples and slightly modified versions of three PCR-based assays.36-38 Patients whose F8 mutations were not identified definitively by sequencing were evaluated for the intron 22 inversion by long-range PCR.36 Unless an intron 22 inversion was definitively identified, the intron 1 inversion assay was performed.37 Finally, unless an intron 1 inversion was definitely identified, a more robust inverse-PCR-based intron 22 inversion assay was performed.38
We considered a patient to have an inhibitor if any screening assay ever had a value of 0.6 Bethesda unit per milliliter or higher.31,32 We designated the background wild-type form of the factor VIII protein encoded by a patient's F8 gene as the exposure on the basis of specified amino acid residues at positions 484 (R or H), 776 (R or G), 1241 (D or E), and 2238 (M or V). On the basis of the alleles of G1679A, A2554G, C3951G, and A6940G, the background F8 haplotypes identified in this study were predicted to encode four of the five wild-type factor VIII proteins observed previously in the black population, namely, H1, H2, H3, and H4 (Fig. 1). Because of the small number of subjects, we combined them into two groups: H1 with H2 (H1+H2) and H3 with H4 (H3+H4). Patients in the H1+H2 group represent nonexposed (control) subjects, since their hemophilic mutations are present in F8 haplotypes that encode the factor VIII proteins represented by or enriched in recombinant and plasma-derived replacement products. The H3+H4 group is composed of exposed (case) subjects, since their F8 mutations reside within haplotypes encoding the black-restricted factor VIII proteins H3 and H4, which are structurally distinct from, and therefore mismatched with, the recombinant (and plasma-derived) factor VIII products used clinically. In an unadjusted analysis, we tested whether the prevalence of inhibitors was significantly different among patients grouped according to their factor VIII haplotypes. We also performed logistic-regression analysis with control for age at enrollment and baseline severity of illness and repeated these analyses in the subgroup of subjects with hemophilia-causing missense mutations only. We used SAS software for Windows, version 9.1.3, for all statistical analyses.
Because the study questionnaire identified several related patients, we were concerned that association of the development of inhibitors with F8 haplotype might be due to the fact that family members, who share the same haplotype, are also more likely to share alleles of other polymorphic loci, including those that may influence the development of inhibitors, such as the genes for tumor necrosis factor α and interleukin-10.39,40 We thus treated patients without affected relatives enrolled in the study as singletons and grouped those with reported affected relatives into pedigrees. We performed a series of both crude and adjusted subanalyses after progressing through all combinations of unrelated subjects, selecting only one member from each family that had more than one affected member, and recorded the resulting odds ratios.
Seventy-eight black patients with hemophilia A were enrolled. We identified the hemophilic F8 mutation in 70 of the 78 patients (Fig. 2). Two full brothers with large gene deletions that included A6940G, the nonsynonymous SNP encoding M2238V (Table 1), were excluded from the association analyses, since they could not be classified within either haplotype group. The mean (±SD) age of the 76 remaining subjects was 17.5± 12.9 years. According to initially recorded measurements of factor VIII, 11 subjects (14%) had mild hemophilia, 17 (22%) had moderate hemophilia, and 48 (63%) had severe hemophilia; this distribution of severity is similar to that seen in cross-sectional studies of patients with hemophilia from other racial groups.42-47
In the black patients with hemophilia, haplotypes H1, H2, H3, and H4 were identified, but not the infrequent H5 haplotype.18 Two patients had one additional, previously unknown nonsynonymous SNP, neither of which was predicted to cause hemophilia (see Supplementary Appendix B). The frequencies of mild, moderate, and severe hemophilia did not differ significantly according to the four background haplotypes (P = 0.11). Table 2 shows the relationship between haplotype group and the prevalence of inhibitors. The odds of having a factor VIII inhibitor were significantly higher among patients with an H3 or H4 haplotype than among those with an H1 or H2 haplotype (odds ratio, 3.4; 95% confidence interval [CI], 1.1 to 10.2; P = 0.03). This association remained when we controlled for age at enrollment and baseline severity of hemophilia in a multivariable logistic regression (odds ratio, 3.6; 95% CI, 1.1 to 12.3; P = 0.04).
We excluded the two patients whose F8 genes had different background haplotypes because of the presence of one additional nonsynonymous SNP each. Of the remaining 74 patients, 51 had no reported relative among the study participants. The other 23 patients were members of 11 families (Table 1 in the Supplementary Appendix). When a single patient was selected from each of these families, the sample size for the subanalysis was 62 patients. In analyses of all 3072 possible combinations of 62 unrelated persons, the median odds ratios for the development of factor VIII inhibitors were 2.5 and 2.6 in the unadjusted and adjusted analyses, respectively. The maximum and minimum odds ratios observed in any single sub-sample of unrelated persons were 4.3 and 1.5, respectively, in the unadjusted analysis and 4.4 and 1.5 in the adjusted analysis.
Table 1 shows that 11 different categories of hemophilic mutation types were identified in the 78 black patients. These 11 mutation categories consisted of 31 distinct loss-of-function F8 alleles, 9 of which were previously unknown (Fig. 2).29 This large degree of allelic heterogeneity is similar to what has been observed in previous cross-sectional studies to identify the mutational spectrums in patients from other racial groups.42-44,46,47 Furthermore, among the 70 patients with identified F8 mutations, no difference was observed between the H1+H2 and the H3+H4 haplotype comparison groups in the proportion of patients with higher-risk or lower-risk types of mutation (P = 0.27) (Table 1). To reduce the heterogeneity of the unknown effects of different mutation types, we conducted a subanalysis among patients with missense mutations (the only category large enough to yield a meaningful result), using multivariable logistic regression to control for age at enrollment and baseline severity of illness. The prevalence of inhibitor development was higher in those whose missense mutations resided on a haplotype encoding H3 or H4 (odds ratio, 4.3), although the confidence interval in this small sub-sample of 31 patients included the possibility of a null effect (95% CI, 0.2 to 101.1).
We investigated a potential mechanism underlying the observation that the incidence of factor VIII inhibitors in black patients with hemophilia A is about twice that in whites.9-16 Our previous investigations of nonhemophilic populations (Fig. 1)17,18 led us to predict that the causative hemophilic mutations in approximately 27% of black patients would be present on background F8 haplotypes encoding either the H3, H4, or H5 wild-type forms of factor VIII.30 These haplotypes differ from the H1 and H2 proteins.17,18 H1 and H2 proteins constitute the currently available recombinant factor VIII products21-24 and are enriched in plasma-derived factor VIII concentrates, since blood donors in the United States are predominantly white.25-28 We found that patients with either an H3 or an H4 background haplotype were more likely to have an inhibitor (at some point in their lives) than were patients whose haplotypes were either H1 or H2, a result consistent with our previous findings.48 In this preliminary study, we focused only on black patients to reduce the magnitude of any potential confounding variables due to population stratification across the haplotype comparison groups.49-51
Because the sample size was small, we combined patients into two groups, H1+H2 and H3+H4. The amino acid sequences of the background H1 and H2 proteins correspond to the full-length recombinant factor VIII molecules (Fig. 1C)21-24 and the two factor VIII proteins predicted to predominate in existing plasma-derived products.25-28 We did not have sufficient information about the brands of concentrate to which the patients had been exposed to compare the prevalence of inhibitor development between patients with an H1 haplotype who had been treated with Kogenate (the H1 molecule) and those treated with Recombinate (the H2 molecule), or, conversely, between patients with an H2 haplotype who had been treated with one or the other concentrate. Thus, in our study, the inclusion of all H1 and H2 patients in the reference group could result in a bias toward the null (i.e., it could bring the odds ratio closer to 1 than its true value). Of the three nonsynonymous SNPs whose encoded amino acid residues distinguish H3 and H4 from H1 and H2, two are located in immunodominant epitopes (R484 to I508 [isoleucine at position 508] and E2181 to V2243), sites at which neutralizing factor VIII alloantibodies from most patients with inhibitors interact.2 In our multivariable regression analysis, we did not have sufficient data to control for some potentially important variables, such as previous exposure to plasma-derived or recombinant factor VIII products (or both),9 cumulative days of exposure,9,52 age at first infusion,8 or whether the inhibitors that developed were transient or permanent and of low or high titer.2 We also did not compare the distribution of allelic variants of immune-response genes associated with the development of inhibitors39,40,53 in the two haplotype groups. We did control for age at enrollment and baseline severity of hemophilia, but these are at best poor surrogates for age at first infusion and cumulative days of exposure. We used a conservative approach to account for the effect of related patients, by selecting only one member from each family and progressing through all possible combinations of unrelated persons. The average odds ratios in these analyses differed little from those found for the overall sample. Thus, the presence of some related patients in the study was probably not a source of bias.
We acknowledge that our study has limited statistical power because of the small number of patients and that the results require confirmation. The importance of independent replication is that it would strengthen the evidence that mismatched factor VIII replacement proteins are a risk factor for the development of inhibitors. If our findings are confirmed, the possibility would arise that recombinant DNA technology could be used to develop additional replacement products that vary from endogenous factor VIII proteins only at a residue or residues required to correct clotting-factor deficits.
Supported in part by grants from the National Institutes of Health (HL-71130 and HL-72533, to Dr. Howard) and (HL-70751, to Dr. Almasy).
We thank all the patients who participated in this study, as well as the nurses who enrolled them, including Cara Brown, Valerie Crenshaw, Mary Katherine Noa, April Morris, and Elizabeth Meagher; Deepa Machiah, Thuy Tran, Marjorie Britten, Xiaopeng Mung, and Ming Shen for excellent technical assistance; Pam Bryant for her invaluable role in the administrative aspects of this study; and Bruce Evatt, John Blangero, Vincent La Terza, Johnny Mahlunga, and Georg Lemm for helpful discussions, review of an earlier version of the manuscript, or both.
Presented in part at the 48th Annual Meeting of the American Society of Hematology, Orlando, FL, December 9 to 12, 2006.
Dr. Abshire reports serving on the advisory boards for CSL Behring, Novo Nordisk, and Bayer; Dr. Kasper, serving on a data and safety monitoring board for Wyeth and receiving grant support from CSL Behring; and Dr. Thompson, participating as a site investigator for Baxter, serving as a consultant for Ipsen, and receiving grant support from Bayer. Dr. Howard is the co-founder of Haplomics, which owns a patent application with claims for novel proteins and diagnostic methods that may be useful in treating patients with hemophilia A. No other potential conflict of interest relevant to this article was reported.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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On December 16 2015 the governing body of the National Hydrocarbons Commission (CNH) approved the call for Bidding Process CNH-R01-L04/2015. The bidding process was subsequently published in the Federal Register and the bidding guidelines were published online at www.ronda1.gob.mx.
The bidding process will be conducted for the award of licence agreements for the exploration and extraction of hydrocarbons in deep and ultra-deep waters in the Gulf of Mexico. A total of 10 contract areas will be awarded.
The bidding guidelines are largely based on the same terms as those governing the three previous bidding processes of Round 1.
Operators and non-operators will be allowed to pre-qualify in this process. The guidelines provide for a period during which pre-qualified bidders can decide whether to remain as individual bidders or continue as joint bidders.
For further information on this topic please contact Rogelio López-Velarde, Amanda Valdez, Daniela Monroy or Diego Campa at López Velarde, Heftye y Soria by telephone (+52 55 3685 3334) or email (firstname.lastname@example.com, email@example.com, email@example.com or firstname.lastname@example.com). The López Velarde, Heftye y Soria website can be accessed at www.lvhs.com.mx.
This article was first published by the International Law Office, a premium online legal update service for major companies and law firms worldwide. Register for a free subscription.


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If you have rented out your property under an 'Assured shorthold tenancy agreement', you are entitled to regain possession of it by notifying your tenant under the terms of Section 21 of the Housing Act 1988 (known as a Section 21 Notice).
The Section 21 Notice must inform your tenant that they need to vacate your property on the date the tenancy period ends and you must have given notice to the tenant at least two months before this date.
Our Section 21 Notice will take you through every step of the procedure with comprehensive, jargon-free explanations.


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The popularity of Huma Qureshi is increasing by every passing day. In an interview, she candidly admitted that she had not even dreamed of such a scintillating career. She was happy with her theatrical projects, and some commercials (with Hindustan Unilever and Samsung Mobile). However, destiny had written something else for her. Anuraj Kashyap was looking for a fresh face for his Gangs of Wasseypur. Suddenly, he saw Huma in a Samsung Mobile commercial, and asked her to do the audition for a role. She readily went there, and was selected.
That was just a start. Her role in the both parts of GoW was critically acclaimed, and suddenly she started to get lots of projects. D-Day, Ek Thi Dayan and Shorts are some of her successful projects. Hopefully, Dedh Ishqia will also work better on the screen.
Boyfriends of Huma Qureshi
You might be wondering about the relationship status of Huma Qureshi. There is no denying that she has a very good career ahead of her. With some of great projects, she is projected to become one of the most successful Bollywood actresses of her time. In that scenario, it will be idiotic to expect her getting married in the near future. But, she can remain in a relationship. No?
If you are fan
of Huma Qureshi, you should know that she belongs to Delhi. Her father runs a
chain of restaurants (famous Saleem), and her family stays in GK. She studied
in Gargi College. She had at least two serious relationships during her college
days. The first relationship was with Manoj
Tanwar, a student of Venky's. They used to date in South Ex in Saket. Huma's
favorite hangout with Manoj was Select City Walk, Saket. However, the
relationship could not be maintained for long. Due to some personal issues
(mainly, religious) Manoj and Huma parted ways. She was again hooked up with Ibrahim Ansari, a small time
businessman of Nehru Place. However, she had to say bye-bye to this
relationship because of distance when she shifted to Mumbai (in 2008).
|Huma Qureshi
Huma Qureshi Current Boyfriend
After coming to Mumbai, it was Huma's intention to not get linked with anyone. She was trying her best to get some good assignments. Her audition for Junction could not fructify as the film never came to the floor. She had some good commercial assignments, but she was looking for film projects. She used to see lots of industry people, and as mentioned above finally Anurag Kashyap gave her a big project.
It is said that Huma Qureshi is currently dating Arjan Bawja. I must mention here that quite a little information is available in the public domain about them, but there is no denying that both of them are more close than being called 'just friends'.


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Pan Pacific Hotels Group opens new Global Sales Office
- Published by Ozgur Tore
Pan Pacific Hotels Group has announced the opening of a new Global Sales Office.
The new office in Beijing, complementing its existing Global Sales Office in Shanghai will grow its share of the burgeoning Chinese travel market.
Over the past year, Pan Pacific Hotels Group has been ramping up its developments in China, where it now owns and/or manages four "Pan Pacific" properties – namely Pan Pacific Xiamen, Pan Pacific Suzhou, Pan Pacific Ningbo and Pan Pacific Serviced Suites Ningbo. The Group is on track to open its fifth – the 319-room Pan Pacific Hotel and Serviced Suites Tianjin – later this year and has also announced two more pipeline projects in Chengdu and Zhuhai.
In conjunction with the opening of its Beijing Global Sales Office, the Group has also appointed Charles Cheng as Director, Global Sales, Beijing to head the new Office.
Charles will be responsible for managing the Group's key clients in Northern China and expanding the market through the generation of sales leads and bookings to drive revenue for the Group's properties within and outside of China.
Headquartered in Singapore, the Group currently owns and/or manages close to 40 "Pan Pacific" and PARKROYAL hotels, resorts and serviced suites in Asia, Oceania and North America, supported by a Global Sales network that now spans Singapore, Shanghai, Sydney, Tokyo, New York, San Francisco, London and Beijing.


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A tranquil mix of jonquil, fresh marine ozone and just a hint of precious woods. Our Oceans® home fragrance is part of our outstanding collection of home scents, including reed diffusers, candles and more.
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This $1,900 DOWN OWNER TERMS! home is located at 535 Hackberry Lane in Lafayette. 1686700 was built in 0 and has 0 bedrooms535 Hackberry Lane, Lafayette - MLS 1686700 Close
Land for sale in Lafayette, TN at 535 Hackberry Lane. This land is priced at $2,707/acre.
BEAUTIFUL TRACT! Great sites for a home, Soils for septic, some open, good timber, lots of wildlife including deer & turkey! Nice rural area, city water avail. EZ OWNER TERMS! Only $1,900 down & $545 per mo! MORE DETAILS ON THE MEDIA PAGE
Macon County Junior High School
Listing information last updated on November 23rd, 2017 at 1:39pm CST.
Have any comments or questions about 535 Hackberry Lane, Lafayette, TN? Ask your question and/or share your thoughts about this property.


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Toy libraries are where early childhood fun, creativity and play are valued and promoted!
There are a number of toy libraries located throughout the City of Greater Geelong and adjacent municipalities that provide great support and opportunities for involvement for local families.
At a toy library you can borrow from a vast array of well made toys that have been designed to support your child's skill development and imagination.
Toy libraries aim to support families and encourage togetherness with quality time spent playing with children.
Each week parents and guardians can borrow quality educational toys, puzzles and games for young children.
Toy Libraries:
Provide quality educational items for loan
Are not expensive (usually an annual subscription is charged)
Principally cater for pre-school children
Have a range of items covering all stages of growth and development
Help parents and carers learn about the ages and stages of child development
Are open set days and hours
Toy libraries aim to support families, provide opportunities to encourage children's play, and build on appropriate early learning experiences at home.
Toy Libraries offer parents the opportunity to:
Meet and mix with other local parents
Save money and reduce the costs of providing new toys
Learn about how important play is for your child's development
Maintain positive play stimulation for children
Expose your child to a greater range of play experiences
Encourage your child to learn new skills and varied play activities
Contribute to your children's early development and education
Support your local community through family participation
Create interest for children by adding a highlight to the week with a trip to the Toy Library
Obtain information about other family support and assistance available in the community
Develop your children's self esteem and confidence
Help prepare your child for kindergarten and school
You can find your closest Toy Library in our Community Directory.


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The Kid with X-Ray Eyes Trailer (1999)
29 June 1999 Comedy, Family 85 mins
Justin and his uncle find X-ray goggles misplaced by an evil crime ring. The criminals kidnap Justin, his uncle, and the Feds and Justin has to rescue everybody.
Watch the official The Kid with X-Ray Eyes 1999 trailer in HD below or find more The Kid with X-Ray Eyes videos on Vidimovie.


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- Please select a date to see the proper prices!
Description of the accommodation:
Rooms, services Staybridge Suites Durham-Chapel Hill-RTP Durham is offering 99 comfortable rooms to guests looking for accommodation in Durham. If you feel like having a meal not included in your chosen type of catering, you can always taste local dishes in the restaurant of the hotel. The bar has excellent atmosphere for a relaxed evening talk or a personal meeting. In case you'd bring your laptop along, you may go online via wireless Internet connection (WiFi) available at the hotel. The exact equipment and the exact list of available services of Staybridge Suites Durham-Chapel Hill-RTP Durham can be read on the information sheet below.
Payment Credit card guarantee or advance bank card payment may be required for the reservation, depending on the chosen room, date and price.
Arrival, opening hours The earliest check-in time is 15:00, the latest check-out time is 12:00. The personnel can communicate with you in English.
Staybridge Suites Durham-Chapel Hill-RTP Durham rooms Rooms
- Please select a date to see the proper prices!
Accommodation services
Free WiFi in shared places
- Pool (Outdoor - seasonally open)
Pet friendly, Bar
Own restaurant
Hairdryer, Fridge, Desk in the room, Microwave oven, Tea/coffee-maker


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These old boats look like they have been washed up and abandoned on the shores of Philipsburg on St. Maarten Island. Given that the days here are getting shorter and shorter, and the temperatures colder and colder I think I would like wash up on a beautiful beach in a warmer climate. I have had a nasty cold over the last few days, clearly from the last couple of posts I have been dreaming of a winter holiday somewhere warm
this image and more are available for purchase at jmeyersforeman photography


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Buffett : The Biography Paperback
by Roger Lowenstein
Starting from scratch, simply by picking stocks and companies for investment, Warren Buffett has amassed an astonishing fortune - a net worth of $64 billion and counting.
His awesome investment record has made him a cult figure popularly known for his seeming contradictions: he is a billionaire with a modest lifestyle, a phenomenally successful investor who eschews the revolving-door trading of modern Wall Street, a brilliant dealmaker who cultivates a homespun aura.Journalist Roger Lowenstein draws on three years of unprecedented access to Buffett's family, friends and colleagues to provide this definitive inside account of the life and career of this American original.
He explains Buffett's investment strategy - a long-term philosophy grounded in buying stock in companies that are undervalued on the market and hanging on until their worth invariably surfaces - and shows how it is a reflection of the character of the man himself. And in a brand new afterword, in the wake of the news that Buffett has decided to give the bulk of his fortune to the Bill and Melinda Gates foundation, Lowenstein reflects on the largest charitable donation in American history.
- Format: Paperback
- Pages: 512 pages, Illustrations
- Publisher: Duckworth Overlook
- Publication Date: 11/09/2008
- Category: Biography: business & industry
Free Home Delivery
on all orders
Pick up orders
from local bookshops
Also by Roger Lowenstein


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CodePlexProject Hosting for Open Source Software
I have found a problem with RmAttributeValue and RmResourceChanges, and to fix it I introduced a compatibility-breaking bug.
The point is that the GetDifference function of RmResourceChanges was treating everything as either an Add or a Remove operation,while one should use a Replace operation for single-valued attributes. It was then the resource factory that, knowing the schema,
transformed Add and Remove changes to Replace. However, with a single valued attribute, this ended up creating two operations: an operation "Add new value" and an operation "Remove previous value", then transformed in two Replace operations.
In some cases this could cause an exception and make the operation fail.
I thought that the best thing to do was to treat differently single and multi valued attributes directly in the GetDifference function, but to do this I had to introduce a reliable way of determining if an RmAttributeValue is single or multivalued: the original
mechanism of relying on the constructor called or on the values count was not appropriate - also note that "EnsureAttributeExist" in RmResource was creating everything as a single-valued attribute.
I ended up creating two new classes - RmAttributeValueSingle and RmAttributeValueMulti - but maybe there is a better alternative. I think we should decide this before making our first release.
Please let me know what you think about it.
Hi Paolo,
Is this change stable in the current code?
I have the alternateEndpoint client, the stsEndpointClient, all the cruft required to exchange security tokens, and the passwordReset function implemented on the Default Client.
I am wondering if I should merge my changes with the current code or wait for you to finish working on the change you mention above.
Hi Jeremy,
yes, the change is stable, but before we make a first release of the code, I'm open to other proposals. If you can suggest a way to handle this problem that does not break compatibility, please let me know.
Anyway, I think you can merge your code, then we shall see how to handle the different bits.
Are you sure you want to delete this post? You will not be able to recover it later.
Are you sure you want to delete this thread? You will not be able to recover it later.


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I recently assembled a roundtable of real estate experts to discuss the state of self-storage in the Southeast. I asked them to comment on their local markets, including occupancy levels and pricing. Joining us in the discussion are:
- Allen Barnhill, Omega Properties Inc., Atlanta
- Bill Barnhill, Stuart LaGroue and Shannon Barnhill Barnes, Omega Properties Inc., Mobile, Ala.
- P. John DeStefano, Commercial Investment Group LLC, Charleston, S.C.
- N.J. "Joey" Godbold, Percival McGuire Real Estate, Charlotte, N.C.
- Grady Riggs, Long and Foster Real Estate, North Bethesda, Md.
- W. Frost Weaver, Weaver Realty Group, Jacksonville, Fla.
1. Why is the Southeast a good place to invest in self-storage at this time?
Allen Barnhill: Self-storage offers a great combination of risk and return for a real estate investor. Over its history, and even more important, through the recent economic upheaval, self-storage has proven to be one of the most resilient and consistent performers of any commercial real estate investment category.
DeStefano: The root causes of the current economic downturn are the same factors that drive demand for self-storage (loss/change of job, downsizing household, etc.). Self-storage has proven to be somewhat resilient over the past 18 months compared to other property types (retail, office, multi-family, residential). Self-storage is also well-positioned to recover more quickly than other property types that are dependent on job growth and economic stimulus.
Godbold: We're seeing self-storage holding up well in this market compared to other real estate investments. While occupancy rates and collection issues are haunting operators, the industry hasn't been hit as hard by the recession as most office and retail products. Investors are disenchanted with the stock market and are looking for more tangible and predictable investments, and they see that in self-storage.
LaGroue: Potential investors should purchase self-storage properties because, as a whole, the storage sector has continued to outperform almost all other asset classes of commercial real estate and will most likely continue to do so. Self-storage has certainly felt the pains caused by the recession with declines in occupancy and income figures.
However, it has not been affected as badly as retail, office and industrial, and I don't anticipate that it will. There will also be some buying opportunities from owners or sellers who have upcoming maturities they are unable to refinance due to a lack of funding.
Riggs:Historically, we know self-storage owners tend to sell only when they experience life-changing events, and their decisions are not driven by the commercial real estate market. Entry barriers are generally high for self-storage projects, so as long as an investor can get financing, a well-placed and managed facility is still a good, solid cash-flow generator.
Weaver: There are two primary categories of self-storage properties today, and different types of potential investors. Class-A self-storage properties can provide a stabilized cash flow with less risk than other types of commercial properties. In general, the price for these properties is less than replacement cost.
There's a broad second category of properties that have experienced decline in occupancy based on the economy and the significant decline in new housing starts. These are not returning a net income that can be capitalized, but can be purchased at prices significantly below replacement cost. For the entrepreneur, there is significant upside as the economy in the local area improves.


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Sphinx is a powerful documentation generation tool, as well as a powerful book writing tool. It can generate multiple output formats, including LaTeX for printable PDF versions. However, the LaTeX output is often more problematic than the html output. In this post, a collection of common issues and their solutions are listed.
Category Archives: LaTeX
Live Preview of LaTeX in Vim
Vim, as a highly configurable and customizable editor, already has a powerful Vim-LaTeX plugin. However, I don't like the lack of live preview feature. For this reason, I developed a plugin called vim-latex-live-preview last year. Although it currently can't handle complex situations such as multiple tex files, it could basically handle single tex file project well (with or without BibTeX, thanks to Asis Hallab).
Note: This plugin currently doesn't work on Windows.


text: On November 15,2016 , Our student entrepreneurs were given the opportunity to present their project ideas to bring health and wellness to BDCHS and the surrounding community. The students did an amazing job, and they all had awesome project ideas. Once all of the student were finished pitching their idea, the judges selected 3 students who were awarded a $1,500 grant to make their ideas a reality. Congratulations to our winners and all of the student entrepreneurs! Those who didn't were given the opportunity to submit their ideas online to see if they qualified for project funding! Thank you to the students who committed themselves to this process and also to Adventure Capital and the Dairy Council of Florida.


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By Jason Nault Submitted On October 05, 2009
Everybody knows that no wealth-building strategy is complete without real estate, right? You've read all the experts who say you simply have to invest in real estate to earn the kind of money you need to make your dreams a reality.
oYou've heard all the statistics…
oMost millionaires and billionaires get rich primarily through real estate investments.
oLand is one of the safest, lowest-risk investments you can make.
oTax benefits make real estate a "government sponsored" investment…and makes April 15th a lot more bearable.
oReal estate consistently out-earns traditional investments like stocks and bonds.
And you are probably aware that right NOW, as you read this,
is one of the best times in history to invest in land.
In fact, there may never come a better day in your lifetime to get started in real estate investing…it's a "perfect storm" for real estate investors…
Here's why…
oInterest rates plummeting to historic lows make it very easy for you to buy NOW!
oOver-stretched propertyowners facing balloon payments are highly-motivated to sell to you below market value TODAY!
oDifficult economic times mean more "distressed sellers" enter the market each and every day…needing to fix their financial problems FAST!
oA huge crop of "For Sale" signs makes right NOW one of the best "shoppers' markets" you'll ever see.
Have you ever heard yourself saying…
"No, I haven't invested in land, but I've been meaning to"?
Well, now you have no more excuses.
Just take a look at our property today and you can easily determine the simplest, safest, most affordable way for you to get started realizing your real estate dreams.
All the age-old objections have been shattered…creating a "perfect storm" for would-be real estate investors to finally get in the game.
What's been holding YOU back?
oCan't afford to invest? Not a problem. Low monthly payments, small down payments, and a SUPER LOW 5.9% interest are all available, so you can get started today.
oWorried about credit issues? Not a problem. With optional 100% owner financing there's no hassle, no application, no credit check!
oDon't want to waste hours, days, months trying to find the right property? Not a problem. Just signup for our FREE "Land Alerts " and we when we get that perfect property ill notify you.
oDreading those long, drawn-out approval processes? Not a problem. Just enter your name, address, e-mail, and phone number and get started today.
oNot sure where to start? Not a problem. Just request your FREE "Land Needs Assessment" and step your way through to the right investment to fit your needs.
oWorried about closing cost, commissions, hidden fees, balloon payments or fine print? Not a problem. No costs to pay and no fine print to read.
oAfraid of getting stuck with a "problem property"? Not a problem. You get a "Lifetime Free and Clear Title Guarantee" that covers all of your investments and insures you against hassles and headaches.
NO RISK, NO HUGE DOWN PAYMENTS, NO HASSLES, NO FEES… and lots of beautiful properties to choose from… now what's holding you back?
This "perfect storm" of a real estate market won't last forever…so be sure to take advantage of this historic opportunity now!
Here's what you'll discover today…
oBeautiful land at 40% to 80% below-market prices.
oSafe investments that provide steady cash for your bottom line.
oA profitable investment at terms that are perfectly suited to your financial situation.
oYour choice of residential, commercial or agricultural land…find the right land for you!
oA sense of personal pride in owning your own land.
oGreater wealth for you…and an inheritance to pass on to your loved ones.
oHow you can "control" a property for only a small down payment and minimal monthly payments.
oHow to exploit real estate to save more money on your taxes this year.
"Don't wait to buy land, buy land and wait."
FYI: Anyone can buy cheap land online right now with 100% owner financing at: http://www.landsalesco.com
Article Source: http://EzineArticles.com/expert/Jason_Nault/439128


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Ethiopia Tours and Travel
Ethiopia Tours
Enjoy the best of Ethiopia on this adventure tour to East Africa. This journey of discovery tours Ethiopia's rock hewn churches of Lalibela, the Medhane Alem Feast, Lalibela's Saturday market, holy city of Axum, medieval castles of Gondar, monasteries in Lake Tana and the sacred Holy Trinity Cathedral. Ethiopia is waiting for you to explore her treasures on this awe-inspiring Africa travel adventure.
Ethiopia Trips – 09 Days
Ethiopia Travel Highlights:
Addis Ababa museum and Bahata church, Axum "Queen Sheba's Palace" ruins and Church of St Mary of Zion, UNESCO's World Heritage Lalibela rock-hewn churches, Gondar castles and churches, Weleqa village Falasha Jews, Lake Tana cruise, Bahir Dar, Ura Kidane Mehret Monastery and Blue Nile Falls.
Ethiopia Tours Include:
Economy, business or first class airfare
Mid-range or luxury hotels
Professional tour guide
Arrival and departure airport transfers
Accommodation taxes and service charges
Entrance fees
Sightseeing and meals per itinerary
"Thanks for the truly GREAT service! I will continue to recommend you to all the Americans in the development community here." K. Boyle


text: Have you just landed a new position as a junior Account Executive or Senior Vice President of Sales? In every profession, those who continue to learn and hone their skills are the ones that rise to the top. If you've just been given a new sales goal, follow these strategies from the top sales professionals to close the deal on your next account. … Continue reading the story "Winning Sales Strategies"


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It's been over for a long time
Anyone who runs a real, mainstream Web site has known for at least three years that the browser war is over. Geek sites attract a nonrepresentative sample that masks the extent of Microsoft's domination of the browser marketplace.
AOL may ignite a new browser war as it maneuvers to push TimeWarner/CNN content into the faces of users -- but it does not yet have much of an arsenal and continues to be dependent on Microsoft for its primary browser technology.
Mozilla/Netscape 6.0 is a disaster. It has lost its way in its own religion. Rather than writing code that works -- which OUGHT to be the goal of any developer -- the Mozilla effort has yielded an abstract user-interface model that is theoretically cool and practically unusable. The same can be said of the rendering engine, standards-compliant but real-world ignorant. The Web that Ought to Be is one thing, but we have to use the Web that Is.
Konqueror is an admirable effort, but it's a long way from being finished, it's not as fast as it should be, and (for reasons I have not been able to track down) it really loves goofy fonts.
A tool for securing DNS communications between a client and a DNS resolver.
A polyhedral extraction tool (PET).


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Operation Dance Sensation Trailer (2003)
01 January 2003 Action, Comedy 110 mins
After escaping from the terror of Vietnam, Jackson works as a headhunter. His old enemies from Vietnam open up a disco near the American-Iraqi border. They try to sell dangerous weapons to the Iragi government. Jackson is the only one who can stop them. Besides, he must care about his daughter, age 5. On the birthday party of his daughter, the situation escalates... and there is still a dance competition to be hold.
Watch the official Operation Dance Sensation 2003 trailer in HD below or find more Operation Dance Sensation videos on Vidimovie.


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- Big Idea
- Camps
- Courses & Workshops
- Craft & Design
- DJ Skate Nights
- Free Flicks
- Harbourfront Centre
- HarbourKIDS
- Kuumba
- Learn to Skate
- LunarFest
- Miscellaneous
- NextSteps
- Planet IndigenUS
- Retail
- School Visits
- Summer
- Summer Music in the Garden
- The Power Plant
- Uncategorized
- Visual Arts
- Volunteers
- Winter
- World Stage
The Power Plant
Call for Proposals – Power Youth: Artists-in Residence 2017
CALL FOR PROPOSALS The Power Plant Contemporary Art Gallery (TPP) seeks proposals for creative projects that provide meaningful engagement between youth in priority neighbourhoods and contemporary artists for whom community engagement is central to their practice. TPP's Power Youth program, an extension of our mandate, delivers contemporary art programming for youth ages 11 to17 in partnership with St. Alban's Boys …
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A weekend's worth of art
Looking for something to do this weekend? Come down to Harbourfront Centre for a weekend of art openings, parties and creative shopping. The Centre Shop Newly renovated, our on-site gift and craft shop re-opens this Friday. Browse beautifully-designed and innovative artisan crafts made by local artists in our Craft & Design Studios, plus pieces by many Canadian artists and international designers. …
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Q-Rock the Toronto Bronx Native
Hip hop culture has always been open to the integration of different musical styles, techniques, genres, developments and changes. Widely recognized as a powerful and universal tool for unifying people of all classes, ages and races, the culture has seen different people from all over the globe use it as a form of expression, empowerment and communication. MC/dancer Q-Rock has used the five elements to infuse his culturally rich music and unique perspective, as a Nipissing, Ontario native, into the urban scene.
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Time Out: Christian Marclay's The Clock at The Power Plant
Let's face it – lunch breaks can be stressful. You've only got 60 minutes (if you're lucky). Yesterday, I decided to check out Christian Marclay's seminal video installation, The Clock, showing at The Power Plant.
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Enter for a chance to win tix to Everything Under the Moon!
Our World Stage 2012 season kicks-off February 18th with Shary Boyle and Christine Fellows' Everything Under the Moon. And it just so happens we're giving away a pair of tickets, too!
Read more