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Picture: Lily Allen arrives at the afterparty for 'The Other Boleyn Girl' held at Criterion restaurant in Piccadilly. London, England - 19.02.08
Lily Allen has hit out at U.S. immigration officers, claiming she was interrogated on her arrival in the country about newspaper allegations made against her.
After a similar incident occurred during her last trip to America, the British singer is convinced authorities are following all her tabloid gossip.
Allen - who arrived in Seattle at the weekend (12-13May07) to promote her album Alright, Still - writes on her website blog, "It seems that the American Immigration peoples know things about me that I don't. Twice now I have been questioned over things that are a little dubious.
"I haven't even been arrested, not even questioned. I have never even spoken to a policeman in regards to this incident.
"I doubt that a United States Government agency would use unreliable sources, quoting tabloid gossip and lies as factual evidence, would they?"


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London, United Kingdom (PressExposure) October 05, 2013 -- Beverage startup VAQUA launched a crowdfunding campaign today on indiegogo.com for its first of the line product "INFINITE", a premium beverage developed for those who believe in making the best out of everything, from an extraordinary night out, to an extended working day or study session.
The campaign will allow VAQUA to raise 100,000$ and make it possible to order the first batch of the product and prepare for the development of its next revolutionary product "INFINITE Hydration" which will be specifically designed for athletes and other sports enthusiasts.
INFINITE® Energy Drink
After carrying out several research studies on high quality ingredients and testing preliminary formulas, Vaqua® created INFINITE® Energy Drink, a superior blend now available in 250ml cans, we developed INFINTE, to not just be an energy drink but happiness in a 250ml can.
-It relieves and give the extra boost you need to achieve something extra-ordinary
-We have used happy colors and a sleek design to catch your eye
-Holding INFINITE gives you extra-ordinary feeling, Because its different
Daily life is full of challenges and you need to be up to it, so whenever you need a fresh start, have an ice cold Infinite, a refreshing splash in a 250ml can with a premium blend of invigorating ingredients and vitamins such as caffeine, taurine, B6 and B12.
INFINIT® is a high caffeine energy drink, developed and design for executives, entrepreneurs, students, computer savvy and geeks. its not recommended for children, pregnant women and to be consumed moderately
-Increases Endurance
-Enhances Mental & Physical Performance
-Improves Concentration & Vigilance
-Makes You Feel Ready To Move On
Most energy drinks are high in sugar in the form of high fructose corn syrup and/or cane sugar. Some use creative names to make their version of sugar seem healthier, like "natural cane juice" or they'll call it "glucose".
INFINITE® has a sugar-free variant in addition to its original which contains sugar and is not recommend for people diagnosed with diabetes.
Crowndfunding Campaign
VAQUA has launched its campaign on indiegogo.com, its a well known crowdfunding platform available globally to all industries, businesses and creative ideas, you can access INFINTE Campaign page on the following link contribute, buy and spread the word.
Vaqua®, a company with total focus on energy and nutritional beverages, established in England and Wales in 2010 with the idea of developing premium energy, nutritional and sports beverages.
To learn more about INFINITE and our campaign, please contact
Mohammad Amin Attar

subset: commoncrawl


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Make your wedding even more special by having your first dance or father daughter dance choreographed to your song by one of our expert choreographers. Get ready to dance the night away with your sweetie by letting us show you how to dance to all types of wedding music!
Don't hesitate, let the experience choreographers at Dance With Stars make your wedding spectacular!!!
Call for more info: 281-646-1901
2 Comments
I'm interested in setting up a few classes for myself and my fiancé to learn a dance for our wedding. I'm also interested in setting up lessons with my father as we are planning to dance to "old time rock n roll" and need help! Could you send me information and pricing? Thank you!
Dear Amanda!
Thanks for choosing Dance With Stars Academy!
We will be more then happy to help you out! Please feel free to schedule a consultation with our wedding specialist during which you will find out all your answers. Call to schedule a time spot: 281-646-1901
Best regards.
DWS Team


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After watching the finale again, I realized something. The Island Desmond and MIB were both confused on how they were supposed to GO HOME. MIB thought he could go home by leaving the island. Island Desmond thought he could go home by going into the light of the island. But the opposite for each was true. Let me explain:
Desmond was our clue to understanding what MIB / Smokey meant when he said that he wanted to go home. When Widmore shot Desmond up with a full blast of electromagnetic energy, I think a that island Desmond's consciousness switched places with the Desmond who was still "LOST" in the sideways world. In the sideways world, when Charlie helped Desmond to "remember", Both Desmonds were enlightened. Everyone is the sideways world who had been enlightened were waiting for the other LOSTIES to join them before they could move on.
So, the already enlightened Desmond was on the island instead being in the "waiting room". He was no longer afraid. He was just waiting for his friends so that he and Penelope would move on into the Light. That is why Desmond was guessing that MIB was taking him to the "Bright Light", - so he could finally go home. But this Desmond was in the wrong world, and the Light that he saw did not take him anywhere.
The Desmond in the sideways world was going against Mrs. Hawkings warnings because he was trying to Speed up the process. He knew what was waiting for him and Penny, and he did not want to WAIT for the others to slowly "Wake UP". So Desmond began "helping" them remember things more quickly.
Did Jacob send Desmond to the island to help "free" his brother from his worse than death fate of being a Smoke Monster for eternity? I think so. The Light and water formed a barrier in the heart of the island that Smokey could never cross to go "home". That is why the Smoke Monster was "trapped". But MIB's soul was trapped inside of Smokey and so, MIB was just trying to leave the island and go across the sea just as he did when he was living.
Smokey has never been able to cross the water in Smoke form. So, Jacob needed someone who would be able to remove the cork and drain the water so that Smokey could return to the bowels of the island. To do that, this person had to build up enough resistence to the Electromagnetic Energy so that they could survive long enough to pull the cork out. Once the Cork was removed, the evil fueled by the magnetic energy was returned to the earth and MIB became mortal. Once MIB was mortal he could die like anyone else, and his soul would be free, and so it was.
But now, the island and the Life giving Light were in danger of being destroyed. Jack, did the job he was convinced was his destiny. He fixed the island, saved the world, But more importantly, He fixed himself and he protected the Light....
The same Light that would lead them all home in the end.
Without the Light, they never would have found each other again. And that is how the two "worlds" were able to merge together.
Jacob redeemed himself by dedicating his life AND DEATH in pursuit of correcting the one "SIN" he was responsible for. I think it is really important to remember at this time, WHY it was such an important theme throughout the entire series for Jacob to give CHOICES to those who were on the island. The people that Jacob brought to the island were broken, and like Jacob said: They needed the island as much as the island needed them. Their pasts didn't matter, their slates were wiped clean, and the responsibility for whatever happened to them while they were ON the island rested souly in their own hands.
Every person on the island made the choices that determined their ultimate fate. This was the MAJOR rule on the island. Everyone who came to the island MUST be allowed to make their own choices, even if the options to choose from were less than desirable. What must be done now, is to go back and figure out what choices each person made that led them to their end story.
So, in the end, Jacob redeemed himself. MIB - I feel should not be held responsible for what happened to him because it WASN'T his choice. He didn't choose to become this evil Monster. His soul was helplessly lost inside this creature that was so hideous, it was forced to live in the fiery bowels of the island. A punishment worse than death that he had to endure for over 2000 years.
I don't think that Jacob or MIB needed any time in purgatory. Jacob and MIB have been "awake" for VERY long time. You could almost view the island as their own private purgatory. When they were finally set free, they knew EXACTLY what they wanted.
In the end.... MIB Went HOME by LOSTINHOUSE
After watching the finale again, I realized something. The Island Desmond and MIB were both confused on how they were supposed to GO HOME. MIB thought he could go home by leaving the island. Island Desmond thought he could go home by going into the light of the island. But the opposite for each was true. Let me explain:


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Why an special session at the occasion of the NASA 2012 OCRT meeting? Introduction and Overall Goals of the Special Session David Antoine Chair, IOCCG. Overall goals: To inform the community about IOCCG and its current activities (what, why, who ??)
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
at the occasion of the
NASA 2012 OCRT meeting?
Introduction and
Overall Goals of the Special Session
David Antoine
Chair, IOCCG
What's IOCCG?
IOCCG Committee Members (2012)
Ahn, Yu-Hwan - Korea Ocean Research and Development Institute, Korea
Antoine, David (Chairman) - Laboratoire de Physique et Chimie Marines, France
Bernard, Stewart - Council for Scientific and Industrial Research, South Africa
Bonekamp, Hans - EUMETSAT, EU
Bontempi, Paula - NASA HQ, USA
Chauhan, Prakash - ISRO, India
Crevier, Yves - Canadian Space Agency, Canada
DiGiacomo, Paul - NOAA NESDIS, USA
Doerffer, Roland - GKSS, Germany
Dowell, Mark - JRC, Italy
Dutkiewicz, Stephanie - MIT, USA
*Feldman, Gene - NASA HQ, USA
Greb, Steven - Wisconsin Department of Natural Resources, USA
*Hardman-Mountford, Nick - CSIRO, Australia
Ishizaka, Joji - Nagoya University, Japan
Kampel, Milton - INPE, Brazil
Lambin, Juliette - CNES, France
Mao, Zhihua - Second Institute of Oceanography, China
Murakami, Hiroshi - JAXA EORC, Japan
Pozdnyakov, Dmitry - NIERSC, Russia
Regner, Peter - ESA/ESRIN, Italy
Sathyendranath, Shubha - NCEO, UK, and Plymouth Marine Laboratory
Tanaka, Tasuku - Yamaguchi University, Japan
Yoder, James (Past-Chair) - Woods Hole Oceanographic Institution, USA
*Zibordi, Giuseppe - JRC. EU
Past (report has been published)
Past (report under press)
IOCCG special session: towards an international ocean color science team meeting
9:00-9:10 Introduction and Overall Goals of the Special Session – D. Antoine/LOV
9:10-9:30 The development of IOCCG since its inception, and the role it currently has in the
international ocean color community – J. Yoder/WHOI
9:30-9:50 Current IOCCG activities related to global ocean color CDRs, and rationale for an
International Ocean Color Science Team Meeting – D. Antoine/LOV
9:50-10:10 IOCCG standing working group on ocean color CDRs evaluation – J. Yoder/WHOI
10:10-10:30 Current status of the CEOS/IOCCG INSITU-OCR initiative – S. Bailey/NASA GSFC
10:50-11:10 An example of international science community building: the GHRSST project –
P. Minnett/University of Miami
11:10-11:30 Lessons learned from SIMBIOS, in particular in terms of international coordination –
B. Franz/NASA GSFC
11:30-12:00 Discussion session, in particular about: what would you expect from an annual IOCST meeting? What type of organization/content would be appropriate? What sort of outputs would be useful? Which balance between talks, working sessions, posters would be appropriate – All


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Design plus words, letters, and/or numbers
High chairs; Non-metal safety gates for babies, children, and pets
Business in Van Nuys, CA


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|Property type
|Minimum Stay
|7 nights
Finca La Corbaia is a delightful home away from home in the green, unspoilt countryside near Artà. Visible love to detail concerning architecture, furnishing and decoration create a real Mediterranean ambience inside and out. The cosy partly shaded main terrace leading to the pool and the large landscaped garden provide for ample entertainment and lounging space for the entire family.
The newly built Finca with exquisite panoramic views of the surrounding lush hilly landscape is conveniently situated only 4 km from Artà. The supreme beaches of this region and the ample shopping facilities, restaurants and pubs of Artà and Cala Ratjada can be reached in a few minutes by car, as well as 4 renowned golf clubs.
SWIMMING POOL: W8m x4m.
Villa features
Sleeps 6 people
3 Bedrooms
3 Bathrooms/Showers
1 Bathroom
1 Double Bedroom w/En suite Shower room
1 Twin bedroom with balcony
1 twin bedroom with ensuite shower room
Air Con in Bedrooms
Built-in BBQ
Dining Kitchen
Fridge / Freezer
Hi Fi
Outside Pool Shower
Sat TV
Washing Machine
*Plus compulsory or optional charges based on actual occupancy or consumption. The payment has to be made in the currency offered by the property manager, before use of conversion tool. Payments in other currencies have to be negotiated beforehand with the property manager. The currency conversion tool is provided for your convenience only and is non-binding.


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The Dominican Republic is one of five pilot countries that implement a UN CC:Learn Project on Strengthening Human Resources and Skills to Address Climate Change in 2011-2013. The projects aim at supporting countries in taking a strategic and results-oriented approach to climate change learning. The project in the Dominican Republic is led by the National Council for Climate Change and Clean Development Mechanism (NCCCCDM).
The six-day workshop brings together delegates, education planners, curriculum development specialists, instructors training teachers and teachers from the Education Ministry, Teacher Training Institutions, Universities and NGOs.
UN CC:Learn is a collaboration of 33 multilateral organizations with the aim to strengthen human resources, learning and skills development in Member States through country driven processes. It is included in the "One UN Climate Change Action Framework" of the UN System Chief Executives Board for Coordination (CEB) through the High Level Committee on Programmes (HLCP). The Secretariat is provided by UNITAR. The pilot implementation phase of UN CC:Learn in 2011-2013 is supported by the Swiss Development Cooperation (SDC).


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Garden Ambiance
Rijksstraatweg 238
3956 CW Leersum
Dedon, Barlow Tyrie
pillows, outdoor benches, parasols, lounge chairs, outdoor furniture, tables, arm chairs, chairs, coffee tables, sofas, side tables
The listings above were submitted to Liever, either by the brands or by the stores themselves. Although we strive for accuracy and completeness, unintentional errors and omissions may occur.
Dedon new
Barlow Tyrie new


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South African construction materials group Afrisam has officially unveiled its vertical roller mill (VRM), the first of its kind in Southern Africa to be used for cement milling, at its newly expanded Roodepoort, Gauteng, cement production facility.
The new VRM, the eighth mill to be built on the site since 1936, will increase cement milling capacity by 120tph, adding to the existing three ball mills' 80tph capacity. This will bring the facility's total production capacity to about 1.5Mta.
Meanwhile, a new silo will increase cement storage capacity by 15 000t.
However, this extra capacity will go unused initially, Afrisam COO: cement Dr Stephan Olivier tells Engineering News, attri- buting this to the demand- diminishing effects of the global economic downturn.
However, he expects that cement demand will rise again and that the investment will prove beneficial in the long term, when the extra capacity will be needed.
For now, the VRM will handle the primary milling demands of the plant, while the three older and less efficient ball mills will stand ready in anticipation of increased demand, explains Olivier.
The VRM was also installed to improve operational effi- ciency and reduce the facility's energy consumption levels.
The VRM was sourced from mill supplier Loesche South Africa, owing to the low main- tenance costs and efficient operation that the Loesche mills provide, Oliver says.
"This VRM consumes 20% to 30% less energy for every ton of cement produced than the traditional ball mills and will help us decrease our carbon footprint," says Olivier. "Further, the grinding and classifying take place in one unit, whereas ball mills have separate units."
Source: www.engineeringnews.co.za
Published under Cement News


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"Dunno why the dog was out, owner didnt seem too concerned.
Exactly! It is not that I don't care for the dog but buying a new car in this economy is kinda hard. Like I said not gonna crash my car over a dog let out by a careless master.
In a perfect world we would smack the owner but usually I just call the pound.
Dunno what the outcome was.
The trooper behind me stuck around after telling me to split.
If anythng, he likely called animal control.
I didn't have a cellphone at the time.
Regret having one now.
Ever see those mind numbed robots on "Cops"?
They sit there and say the dumbest stuff possible?
That's what the owner was like.
Haven't seen the dog since.


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Tag Archives: ash trees
An Ash Tree's Story
We know the story all too well… The emerald ash borer (EAB) was discovered in Ontario in 2002. It is native to Asia and is believed to have arrived in North America via wood packaging or pallets. After establishing a … Continue reading
Posted in Canada, CLC Tree Services, House & Home Tagged ash trees, Canada, EAB, emerald ash borer, infestation, insects, invasive species, London Ontario, TreeAzin 2 Comments
Difficult Tree Removal
Sometimes taking a tree down isn't as easy as it would seem. It can be complicated by the overall health and stability of the tree, the density of the tree, and of course the location. This video shows one of … Continue reading
Reaches of the Emerald Ash Borer
It would appear that few areas are exempt from the emerald ash borer anymore. The above map is the most recent consolidated area where ash trees are being regulated. No wood, leaves, mulch, sawdust or ash material of any kind … Continue reading
Posted in Canada, CLC Tree Services, Nature Tagged ash trees, Canada, CLC Tree Services, emerald ash borer, invasive species, London Ontario, TreeAzin 1 Comment
A Day at Camp
Gray skies dropped thick sheets of rain down on the four tree service crews that participated in this year's Ontario Commercial Arborists Association (OCAA) Day of Service on May 7th, 2014. A wet start to the day wasn't enough to dispel the … Continue reading
Continuing the Fight
Yet more examples of what the deadly emerald ash borer (EAB) can do… This ash tree can be found in the playground of a local London-area public school. In their curiousity, the children there discovered that the bark was loose … Continue reading
Posted in Canada, CLC Tree Services, Nature Tagged ash trees, Canadian Food Inspection Agency, emerald ash borer, London Ontario, tree damage, trees Leave a comment


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Sibling Rivalry in Educational Attainment: The German Case
Recent studies exploring sibling rivalry in the allocation of household resources in the U.S. produce conflicting results. We contribute to this discussion by addressing the role of sibling rivalry in educational attainment in Germany. Using the German Socioeconomic Panel (GSOEP) we are able to distinguish how the effects of sibling rivalry vary by cultural affiliation, i.e., among families of West German, East German and foreign origin. We also point out and correct for a reference group problem in earlier papers analyzing sibling rivalry.
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|Date of creation:
|18 Jul 2000
|Contact details of provider:
| Postal: New Jersey Hall - 75 Hamilton Street, New Brunswick, NJ 08901-1248
Phone: (732) 932-7363
Fax: (732) 932-7416
Web page: http://economics.rutgers.edu/
More information through EDIRC
References listed on IDEAS
Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- Ira N. Gang & Klaus F. Zimmermann, 2000.
"Is Child like Parent? Educational Attainment and Ethnic Origin,"
Journal of Human Resources,
University of Wisconsin Press, vol. 35(3), pages 550-569.
- Gang, Ira & Zimmermann, Klaus F, 1996. "Is Child Like Parent? Educational Attainment and Ethnic Origin," CEPR Discussion Papers 1461, C.E.P.R. Discussion Papers.
- Ira N. Gang & Klaus F. Zimmermann, 1999. "Is Child Like Parent? Educational Attainment and Ethnic Origin," Departmental Working Papers 199614, Rutgers University, Department of Economics.
- Gang, Ira N. & Zimmermann, Klaus F., 1999. "Is Child like Parent? Educational Attainment and Ethnic Origin," IZA Discussion Papers 57, Institute for the Study of Labor (IZA).
- Gary S. Becker & Nigel Tomes, 1994. "Human Capital and the Rise and Fall of Families," NBER Chapters,in: Human Capital: A Theoretical and Empirical Analysis with Special Reference to Education (3rd Edition), pages 257-298 National Bureau of Economic Research, Inc.
- Becker, Gary S & Tomes, Nigel, 1986. "Human Capital and the Rise and Fall of Families," Journal of Labor Economics, University of Chicago Press, vol. 4(3), pages 1-39, July.
- Gary S. Becker & Nigel Tomes, "undated". "Human Capital and the Rise and Fall of Families," University of Chicago - Population Research Center 84-10, Chicago - Population Research Center.
- Behrman, Jere R & Pollak, Robert A & Taubman, Paul, 1982. "Parental Preferences and Provision for Progeny," Journal of Political Economy, University of Chicago Press, vol. 90(1), pages 52-73, February.
- Robert Kaestner, 1997. "Are Brothers Really Better? Sibling Sex Composition and Educational Achievement Revisited," Journal of Human Resources, University of Wisconsin Press, vol. 32(2), pages 250-284.
- Robert Kaestner, 1996. "Are Brothers Really Better? Sibling Sex Composition and Educational Achievement Revisited," NBER Working Papers 5521, National Bureau of Economic Research, Inc.
- Ashish Garg & Jonathan Morduch, 1998. "Sibling rivalry and the gender gap: Evidence from child health outcomes in Ghana," Journal of Population Economics, Springer;European Society for Population Economics, vol. 11(4), pages 471-493.
- Becker, Gary S & Tomes, Nigel, 1979. "An Equilibrium Theory of the Distribution of Income and Intergenerational Mobility," Journal of Political Economy, University of Chicago Press, vol. 87(6), pages 1153-1189, December.
- Thomas Bauer & Ira N. Gang, 1999. "Siblings, Their Sex Composition and Educational Attainment in Germany," Vierteljahrshefte zur Wirtschaftsforschung / Quarterly Journal of Economic Research, DIW Berlin, German Institute for Economic Research, vol. 68(2), pages 215-221.
- Behrman, Jere R & Rosenzweig, Mark R & Taubman, Paul, 1994. "Endowments and the Allocation of Schooling in the Family and in the Marriage Market: The Twins Experiment," Journal of Political Economy, University of Chicago Press, vol. 102(6), pages 1131-1174, December. Full references (including those not matched with items on IDEAS)
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The 56 are fantastic. I loved the group in the Scottish Parliament between 2007 and 2011 because they were so loyal under the most extraordinary circumstances and they would go through fire to maintain the government. In terms of talent, raw political talent, and breadth of ability, this is an extraordinary group and a deep reservoir of skilled politicians.' Alex Salmond
After the Scottish National Party's historic clean sweep in the 2015 General Election, destroying Scottish Labour and the Liberal Democrats North of the Border, this is a timely and in-depth examination of each one of the 56 individuals, many from outwith the political establishment, who now represent the vast majority of Scotland at the Westminster Parliament.
Who are they? Where have they come from and what has been their journey into politics? What motivates them? Who or what inspires them? What is their vision for Scotland's future?
We are the 56 is a timely record of the seismic changes in Scottish politics and a fascinating insight into the compelling human stories behind the political headlines.
Praise for We Are The 56
'…a marker of the historic upset of May 2015. […] Allowing the MPs to speak for themselves, as Bircham and Costello do, lets us see what they are really like. And in many cases that is talented and conscientious politicians…' Stephen Daisley, STV


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Yesterday's London Selenium Meetup was great and topics covered by both the speaker are very close to my heart. Both the speakers, Richard and Haroon spoke about the need to go beyond checks in test automation.
In many teams, automation is viewed as a tool to confirm checks. There is nothing wrong with this definition, however, when you look at the automation in this way, it limits the benefits you can derive from the automation.
However, when you think of automation as testing assisted by tools, you can derive much more benefits.
Both Haroon and Richard shared different ways in which they used Selenium WebDriver and other automation tools to assist their testing. Unfortunately, this talk was not recorded, but I am hoping that Richard and Haroon will post their slides on their blog/sSlideshare etc.
I am sharing some of the techniques they suggested. You may already know some of them, but if not, give them a go and take your test automation efforts beyond checks.
- Use Proxy with your automation and analyse network traffic / check for vulnerabilities
- Use add-ons such as Wave with firefox to get information on accessibility
- Take screenshots even when assertion passes and goes over them quickly to check for defects.
- Automate your data related operations to assist manual testing – set-up / clean-up / migration / sanity checks
- Testing in prod – extend automation / CI to monitor prod environment
- Don't be limited by the environment, use tools at your disposal to overcome limitations.
- Most importantly, always start with HOW AM I GOING TO TEST IT?
It was great to meet so many testers. Hope to see you again soon!


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40%-70% Summer Sale Going On Now At Transformations Med Spa in CT
70% OFF Laser Hair Removal (select areas below) 6 treatments + 3 free= 9 Treatments for the following: 1 facial area bikini line underarms 2 facial areas back, shoulders, upper arms Take an additional 30% OFF already reduced laser hair removal prices to ALL OTHER body areas! 60% OFF Non-Surgical facelifts (micro-current) 10 sessions: 40%... Read More
Learn More About Transformations Med Spa With Lindsay Ladeluca and Western Mass News!
Western Mass News – WGGB/WSHM [ Recently, Transformations Med Spa & Fitness was featured on Western Mass News! Below is the transcript from the video and Western Mass News.] WINDSOR, CT (WGGB/WSHM) – Laser hair removal has become the latest trend when it comes to getting rid of unwanted hair for men and women. Each... Read More
Get your questions about Laser Hair Removal answered
Racquel Rowe and Astri Sherman answer questions about Laser Lipo, Laser Hair Removal, Non Surgical Facelifts, and everything else Transformations Med Spa & Fitness as to offer. Take a look! If you still have some questions, check out our Q&A page.
Laser Lipo Holiday Prep Special
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A Message from Astri
The cat is away so the mice will play! Racquel is on vacation and out of the country. She is soaking up the sun, so now it's time for you to have some FUN!! Come and play and I will make your day! 50% OFF ALL SERVICES! Contact Transformations Med Spa and I will meet you... Read More
Happy Labor Day
Transformations will be closed from Saturday 9/3 to Friday 9/9. Enjoy the long weekend!
Summer Closings!
The Medical Spa will be closed From Monday the 15th to Wednesday the 17th. Racquel is taking her daughter back school and will not be taking any appointments on these days. Thanks!
2 Year Anniversary Sale
We are celebrating our 2 year anniversary! From now until August 6th we're offering 20% off Micro-Current, 20% off Laser Lipo and 65% off Laser Hair Removal.
Open House – Friday and Saturday 22nd and 23rd
Please join us for an open house this weekend. To RSVP, please call (860) 595-9105.


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Comeback news of the week
Are MTV really bringing back Beavis & Butt-head? Cool! ("Hur-hur, you said 'come'." "Fartknocker." "Buttmunch." "Bunghole." Etc, etc.)
This week's best attempt to be more prolific than Prince
Wiley's dropped his management and uploaded 11 Zip Drives'-worth of tunes (over 80 all-new tracks) on to the internet. Some quite good.
Employees of the week
New film Ready, Set, Bag! documents the National Best Bagger contest in Vegas – for people who really, really excel at packing supermarket shopping.
Pig Fact Of The Week
The sex pheromone given off by a virile boar is the same as the chemical contained in truffles (Private Life Of Pigs, Thu, 8pm, BBC2). We think this means truffles = Old Spice for boars. Oink!
Best new short band names of the week
1. Bim. 2. Dom. 3. Mopp.
Ensemble Album Of The Month
TV On The Radio guitarist Dave Sitek lures David Byrne, Karen O and more into his Maximum Balloon crew.
Omelette assessment of the week
"Looks like it's got egg in it." Brookside's Alex Fletcher gets cooking on Celeb MasterChef (Wed, 8pm, BBC1).
Why are you still here of the week?
John Barrowman.
For daily updates and stuff visit twitter.com/guideguardian and guardianguide.tumblr.com


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text: Putting you just a 5-minute drive from Se Cathedral and Nossa Senhora da Paz Theater, Hotel Portas da Amazônia offers an airport shuttle (available on request) for BRL 50 per vehicle. Free perks include WiFi and hot/cold buffet breakfast daily between 7:00 AM and 9 AM. Rooms offer LCD TVs and minibars.


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When making a will, it is perfectly acceptable to be influenced by people - but where this influence becomes undue, then the will might be challenged.
The question of what amounts to undue influence rather than simply influence has often been considered by the Courts. For influence to become undue, it must involve coercion.
A case in which coercion was shown was Schomberg v Taylor [2013] EWHC 2269 (Ch). The case concerned the will of Mrs Taylor. In 2005, she made a will leaving the bulk of her estate to her two stepsons, with whom she had a very good relationship. Her brother in law, Mr Peskin, had previously been named executor in her will but had been removed after asking for money from Mrs Taylor.
Following the death of her husband in 2008, she had been very vulnerable emotionally and physically - undergoing surgery and suffering from depression.
During that time, she had received numerous phone calls from Mr Peskin who 'persuaded' her to change her will and leave the bulk of her estate to his three children (to whom she was not close). He was suffering financial difficulties, and wanted to get some sort of security for his children in the future. It was reported that Mrs Taylor felt under a lot of pressure from him - bursting into tears during a conversation with a friend and saying that she could not cope and did not know what to do about her will.
Eventually, in order to get Mr Peskin off her back, Mrs Taylor agreed to make a new will leaving her estate to his children and very little to her stepsons. On her death, they challenged the later will and were successful. The Court found that Mrs Taylor had been extremely fragile after her husband's death and the persistent pressure from Mr Peskin amounted to undue influence. Mrs Taylor had changed her will only to stop him from continuing to harass her.
An example of where an argument of undue influence has not succeeded is the case of Brennan v Prior [2013] EWHC 2867 (Ch) where it was found that the testators will had not been overborne, although he had had been persuaded to change his will.
The case concerned the estate of Francois Devillebichot. He had one daughter who was estranged from the rest of the family. He was not named on her birth certificate (there was a dispute over paternity which had to be resolved using DNA evidence) although they did have a relationship.
Mr Devillebichot had a history of illness, and was diagnosed with cancer in 2009. He had considered making a will on several occasions, but had not actually done it. His daughter's evidence was that he had intended to die intestate so that she would inherit his estate.
In 2011, his cancer was diagnosed as terminal and he and two of his four siblings discussed making a will. He was unable to communicate easily by that time, and so the siblings drafted the will. He was admitted to hospital, and the siblings and executors visited him and got him to sign the will. That will left his daughter £100,000 and left the remainder of the estate to his siblings.
His daughter challenged the will on the grounds that it was not properly executed, that the testator lacked capacity, that he did not know and approve of the contents of his will and that there was undue influence from the siblings. She did not succeed. In terms of the undue influence allegation, the Court found that she had not proved that there was coercion - pressure which overpowered the freedom of action of her father. There had been persuasion by his siblings, but this was not sufficient to amount to undue influence.
The question of whether there has been undue influence will depend heavily on the facts of the case - the characters of the testator and the influencer, the factors which might make the testator vulnerable to coercion and the amount of pressure placed on someone. This can make these cases difficult to predict, and the more evidence that can be gathered to support the case, the better.


text: 2014-2015 Real Madrid Adidas Allweather Jacket (Black). Official 2014-15 Real Madrid Allweather Jacket, available to buy online in adult sizes S, M, L, XL, XXL, XXXL.This jacket forms part of the Real Madrid 2014 2015 training range and is manufactured by Adidas. This hooded jacket is black in colour.Train whatever the weather in this black Real Madrid training jacket which is built from a breathable mesh fabric to keep you cool and comfortable as you heat up. Featuring a waterproof outer to protect you from the rain, you can wear this Real Madrid all weather jacket all year round.Benefits of this Real Madrid training jacket•Waterproof•Reversible pockets•Breathable mesh fabric•Hood includedProduct Code M37196


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(Posted for Glenn Quarles)
Friends SpeedWeek 2017 was pretty much awesome! We had great weather most of the 9 days, small numbers of boaters and pretty much all the running time anyone wanted! When it was all said and done we have 18 record applications that I will be submitting. I will write more details later, lots of people to thank!!! Great job guys!
Here is a pic of the record board..,


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Slovakia deported an Algerian convicted in France and Britain for alleged links to Islamic terrorist networks to his homeland, Interior Minister Robert Kalinak said Thursday.
Mustapha Labsi is subject to an international arrest warrant from Algerian authorities, where he has was given a life sentence in absentia for cooperation with terrorist groups. He was detained in Slovakia in May 2007.
"The deportation of Mustapha Labsi is a victory of common sense and a guarantee of security of our citizens," Kalinak told a press conference.
Slovakia deported Labsi to Algeria earlier this week under a guarantee he would not be tortured or executed, Kalinak added.
Labsi applied for asylum in Slovakia several times but the Supreme Court rejected his request. Its ruling came into force on April 16.
In 2006 Labsi was sentenced in France to six years in prison after being linked to an attempted attack on an international summit in the city of Lille in 1996.
He was however deemed to have served out his sentence while awaiting extradition from Britain.
In Britain he was found guilty of supplying false documents to the network of Ahmed Ressam, an Al-Qaeda member convicted in the United States for preparing a bomb attack on Los Angeles airport in 1999.
Labsi has also been accused of involvement with an international Islamist network with links in Belgium, Britain, Canada and Turkey.


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The New York Giants won Super Bowl XLVI in the 2011 season despite having key players out for extended periods of time due to injuries. The Giants also lost TE Kevin Boss and WR Steve Smith in free agency, two key players as rookies in the Giants' win in Super Bowl XLII. General manager Jerry Reese was roasted in the media for not doing anything to retain either of them.
Reese then went ahead and proclaimed the Giants were a championship team with the talent that was on the roster. Many people laughed at that claim, looking at how the Philadelphia Eagles obtained talent and were promptly dubbed the "Dream Team." The "Dream Team" struggled and failed to make the playoffs. The Giants won the championship.
The media lauded the Giants for being able to replace injured players with productive backups. The emergence of DE Jason Pierre-Paul certainly helped, since the Giants were missing DE Osi Umenyiora for the first half of the season. The emergence of WR Victor Cruz was even bigger, considering they lost Smith in free agency and then WR Domenik Hixon in the second game of the season.
However, while those players are applauded, there is only one player greatly responsible for the Giants and their ability to stay afloat during tough times. That guy is QB Eli Manning. The Giants have never had a losing season with Manning as the quarterback in a full 16-game season. The Giants have also been in the playoffs for five of the eight seasons Manning has been the starting quarterback.
The Giants recently cut three players from their recent successful Super Bowl run. However, the Giants are still championship contenders. Why? They have the one constant that is able to rise up and take this team to championship seasons. This is why Manning is elite. There are only six players that are on contract for next season who was on the 2007 championship team.
There are constant moving parts, just like the New England Patriots this past decade. However, the one constant has been QB Tom Brady, and that's all the Patriots need in order to be championship contenders. Manning is in a class with very select company. If Manning were to go down with injury, it would be devastating for the franchise.


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Al Jean - Still Excited for The Simpsons, 20 Years Later
Here's s startling fact – Sunday night Fox will usher in the 20th season premiere of Matt Groening's unsinkable animated hit, The Simpsons. That means that this spin-off of a Tracy Ullman Show skit has been on the air for 19 years and has amassed a whopping 420 episodes under its shorts…it's mind-boggling, perhaps even "unpossible!"Yet it's true, and the cast and creative team together has 24 Emmy awards, a Peabody, and a Golden Globe nomination (for The Simpsons Movie) to prove it. It's now the longest running animated series in the history of U.S. television and watch out Gunsmoke and Lassie, the cast is signed up for three more years. Executive producer Al Jean has been with the show from the start and is embarking on his eighth season as showrunner. Wednesday he chatted with Newsarama and some other media outlets about what fans can expect this season, highlights of the show's entire run and if there are plans for The Simpsons Movie Part Deux. Newsarama: Al, it's been two decades since The Simpsons debuted. In the past two decades how have you seen the animation industry change? Al Jean: I love animation. I think it has been a golden age in both film and TV. The biggest technological change has been the influence of computers. When we started, it was hand-drawn animation in films only, and now with hand-drawn animation, we were one of the last movies ever. The other thing that has happened is television – even though there were shows in primetime in the past, like the Flintstones - I don't really think they were aimed at adults. I think they were aimed mostly at children. I'm not saying we tried to have risqué content, per se, although that is partly the case, but we have aimed our show at the adult audience and done things that we think are smarter. The kids won't necessarily get it, but they'll watch because of the forum. NRAMA: As far as all the celebrities you've had on the show, is there anybody you just have never been able to get for whatever reason, either in the past or currently? Jean: Yes, it's one group - U.S. Presidents. We've tried to get them going back to – I think Richard Nixon was actually the first when he was still alive. They've all said no. Ronald Reagan, or his assistant, wrote us a very polite no, but that was the closest we got. NRAMA: The Simpsons has broken TV records for longevity but Law and Order is close in that race. Do you plan to stay on top of them? Jean: You know, I hate to admit it; we actually do count episodes. I think we're about 12 ahead of them. They started a little later and they do slightly fewer per year. In number of episodes, we're ahead of them, but we're still behind Lassie and Gunsmoke. Gunsmoke did 600, they used to do 40 a year, so that's a tough one. We are up to 445 in terms of the record [by the end of season 20]. NRAMA: You've been doing the show for a very long time. How do you stay interested? Is it just a job now? Jean: No, it's never just a job and it's a great job. What keeps me interested is when you see something that is a good idea, you're able to take it to the writing staff and translate it into something that is funny and a pleasure to watch. It's the greatest way to vent what you feel about life, it's just a wonderful place to be, and I'm really happy to be there. NRAMA: It's been announced that Anne Hathaway, Jodie Foster, and Seth Rogen are already down for voices this season. What are their characters? Jean: That's true and this week, we also recorded Ellen Page (Juno, X3). With Jodie Foster – sometimes we do these trilogy episodes, and this one has powerful women through history. We do a parody of The Fountainhead, the Ayn Rand book, where Maggie Simpson is in a preschool where she's trying to build these beautiful block buildings and the preschool teacher keeps knocking them down because it's too creative. At the end, she goes on trial, like the end of The Fountainhead, and Jodie Foster does Maggie's voice. And then Anne Hathaway, we do a show where Bart meets a girl who is really sweet and thinks he's really a nice kid and not a brat, so he tries to hide his true identity from her and then she finds out what he's really like and they break up. She was very funny; she's really hilarious to work with. Seth Rogen actually co-wrote with Evan Goldberg the episode. The episode that he's in, Comic Book Guy creates a superhero called Everyman, and his power is that any comic book that he touches, he gets the powers of the hero of that comic. They make a movie starring Homer but Homer is overweight and doesn't look like a superhero, so Seth Rogen plays a personal trainer who is going to get him in shape. NRAMA: People look forward to the annual "Treehouse of Terror" every year. But after 19 years of doing all of the horror tropes, do you have a tough time coming up with that big episode every year? And what can we expect this year? Jean: No, in fact this year is a really fun one, it airs November 2nd. The opening we do a little thing about the election where Homer tries to vote for Obama, but the machine keeps changing it to McCain and then he finally kills him [laughs]. We also do a satire of the fact that they can take dead celebrities, put them in commercials, and do whatever they want, so Homer starts killing living celebrities so they can use them in commercials. Again, we have a parody for the first time of It's the Great Pumpkin, Charlie Brown, where our character, The Grand Pumpkin, totally different legally, comes to life and he's so mad at the way humans treat pumpkins that he tries to kill them all. NRAMA: With another Emmy this year, do you guys ever think that there should be an end date for the show or will you keep doing it as long as there is still this kind of popularity for it? Jean: I'll tell you, we signed the cast for four years, including this one, just recently and the Emmy was wonderful. I really feel, creatively, we're still doing terrific work and I don't see an end for a while. The movie and the ride [that opened at Universal Studios in May] were both huge successes, so I think people still really want The Simpsons in their lives. NRAMA: It has been awhile since the last complete season DVD. What are the plans for more Simpsons DVDs? Jean: There is one coming out by the end of the year, I believe November, for season 11. Two reasons they slowed down, we were working on some of the other things, so our time was taken up, and also, we had a movie DVD come out and we had the ride at Universal, so we didn't want to overdo how many things had The Simpsons name on them. We really do think it's important to keep the quality up and not saturate the market. NRAMA: Everyone loves Spider-Pig [from The Simpsons Movie] and you've done a couple cameos with him. Could we ever see Spider Pig again, or maybe a whole episode devoted to Spider-Pig? Jean: We might. The biggest thing with the movie was we wanted to make it stand-alone. We really hoped that if people had never seen the show, they could enjoy the movie and we also didn't want it to be one of those things where the movie required you to watch the show. We wanted the movie to come to a complete end, but everyone liked Plopper [a.k.a. Spider Pig], so we'll try to bring him back. We've had cameos and if we have an episode; we'll do it. NRAMA: Given the success of The Simpsons Movie domestically and internationally, are you considering doing a follow up to, or a second Simpsons movie? Jean: We definitely would love to do it if we had a script we believed in as much as the first one, but that script took four years to do and that was after it took a while to make a deal with the cast. My preference would be, because it was so much work to do both the show and the movie simultaneously, to wait until whatever that day is when the show is done, and to do another movie. I think it will probably happen, but we're just not working on it now. And to me, nothing is more important than making the show as good as it can be. THE SIMPSONS season premieres this Sunday, September 28 (8:00PM – 8:30PM ET/PT) on FOX. Related Stories:
Fox's 'Animation Domination;' Remembering Toonami
Twitter activity Tweets by @Newsarama


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The 'Center' Has Shifted
Originally printed 4/4/2013 (Issue 2114 - Between The Lines News)
Once upon a time it took political courage to stand up for LGBT rights. Mainstream journalists, elected officials and governmental agencies treated LGBT people with anything from open distain to polite tolerance. As recently as 2004, the Democratic candidate for President, John Kerry, would not speak out against blatant discrimination espoused by the proponents of the anti-marriage amendments that appeared on ballots in 11 states, including Michigan.
Fast forward to last week when the U.S. Supreme Court heard oral arguments in two cases dealing with whether same-sex couples should be able to enjoy full marriage rights. At one point, Justice Elena Kagan noted that the 1996 Defense of Marriage Act, signed by President Clinton, targets only one group of Americans and that "Congress's judgment was infected by dislike, by fear, by animus." The 1996 House Report, she noted, reads in part: "Congress decided to reflect and honor a collective moral judgment and to express moral disapproval of homosexuality." Her point was that the "animus" towards gays and lesbians, clearly defined in the Congressional Record, is no longer an acceptable rationale for discrimination.
She articulated reality - that the general attitude towards LGBT people has shifted, and that just not liking a whole group of Americans has no place in our collective political discourse.
We wholeheartedly agree. And we know that the cause for this rapid and profound shift in public opinion is that many more LGBT Americans have stepped out of the closet. Anyone who says that they have never met or don't know a gay American is now viewed as out of the mainstream. And we know that the direct, personal experience of knowing someone who is LGBT is the primary factor in changing people's attitudes.
We have been delighted by the specter of Republicans and Democrats tripping over each other in their rush to issue statements of support for full marriage rights. Sen. Bob Portman (R-Ohio), one of the most conservative U.S. Senators, voiced his support for marriage last week, and said his change of position had a lot to do with having a gay son. President Obama, former Secretary of State Hillary Clinton, former President Bill Clinton, cadres of congresspeople, senators, governors and mayors have collectively and individually issued statements of support.
Both of the U.S. Senators from Michigan, Carl Levin and Debbie Stabenow support marriage equality. Sen. Levin co-sponsored the 2012 bill that would have repealed DOMA, and Sen. Stabenow issued this statement last fall: "Gay and lesbian couples should not be denied the ability to pledge their love and commitment through the civil institution of marriage. I believe that two committed adults of the same sex should be able to receive a government-issued marriage license, while religious institutions retain their right to determine which marriages they will perform."
Anti-LGBT diatribes that were once the norm of the political right are now regarded as unacceptable. Reactions were quick and harsh against Dave Agema, a Republican National Committeeman and former Michigan legislator, who last week described us as "living a filthy lifestyle" and posted an article on his Facebook page that accuses gays of being diseased, alcoholic and responsible for half the murders in the country. His outrageous comments attracted national news and calls for his resignation, because Republicans fear his opinions are so far out of the mainstream that it will cost them votes and financial support, especially among young voters who overwhelmingly support LGBT rights and marriage equality.
Once upon a time it would have been only us calling for his resignation. Now it's even people in his own party.
This Sunday BTL hosts the 3rd Annual Same Sex Wedding Expo at the Detroit Marriott Livonia. Hundreds of people will mingle with vendors, munch on great food and sip wine. Many will be planning their nuptials. Even though its not legal yet in Michigan, we can feel that the center of public opinion has already shifted in our favor, and with enough time and momentum what once felt like a fairy tale will become the real story of the LGBT rights movement - full marriage equality in all 50 states.
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- Hillary Clinton's Commitment to LGBT Equality Stronger Than Ever
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As an openly gay man, Fred Hoffman said, "I really didn't know if there would be an issue." And while he wasn't waving rainbow flags when he was recruited by Chrysler in 1988, he was told being gay wasn't a problem.View More Automotive
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Easter Eggs Live (6 x 3-min + 2 x 60′) – The egg is one of nature's most ingenious creations. Now a new series of live Easter programmes and live streaming at channel4.com/eggs will reveal the wonderful – and downright weird – world of eggs for the first time. The programmes are presented by Mark Evans, alongside Jimmy Doherty and amphibian enthusiast Lucy Cooke as well as leading experts.
From crocodiles to cockroaches, fish to frogs, turtles to termites, sharks to snakes, penguins to preying mantis and spiders to salamanders, 99% of life comes from an egg. The programmes will show amazing imagery of hatching across a wide range of homegrown and exotic eggs from around the world.
Broadcast from a striking, state-of-the-art hatching studio, the programmes will be a TV and science first, exploring the new science of embryonic behavior across the animal kingdom and promising startling new insights into animal behavior from the hidden world inside the shell.
Using the very latest equipment, including powerful scanners and super-sensitive microphones, the programmes will reveal the beginnings of life like never before and show the remarkable, life-or-death journeys animals make as they break out and begin life in the outside world.
Viewers will be able to listen in, for the first time, as, BAFTA award-winning sound recordist Chris Watson wires up the eggs for sounds and vibrations. He will eavesdrop on reptile heartbeats; listen in to bird embryos talking to their siblings and calling out to their parents for attention and tune in to insect eggs as they explode into life.
The programmes will also reveal that some bird embryos learn 'secret passwords' from their parents – a single note that they sing when they hatch. They will also showcase never-before-seen footage of lizards hatching early to escape danger; unveil unseen images of caterpillars transforming into butterflies inside the cocoon and scientists will, for the first time, attempt to grow man-made eggshell.
And Mark will be making a live phone call to Australia – to a croc!
From Monday 25th March, 17 'egg streams' will be going live. Follow the eggs 24/7 and catch them at the all-important moment when they hatch. There'll be crocodiles, emus, penguins, spiders, turtles, snakes….every animal featured in the programmes.
And once the animals have hatched, 'Baby Cam' will stream all the baby animal action live. A team of natural history experts will be working around the clock to provide updates and answer your questions. And join us online straight after the programmes for an after-show chat with our presenters.
Viewers can follow all the action around the clock at channel4.com/eggs
Producer: Windfall Films
TX: 25th March 2013
Source: Channel 4 press release


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Staff Selection Commission invites SSC CGL Recruitment Application Form to select candidates for various Group 'C'
and Group 'D' posts. Interested Candidates who get hired for the offered SSC CGL Vacancies can apply by submitting online application form on or before last date. Rest details about SSC CGL Application Form Notification such as qualification, application fee, how to apply etc are well equipped in the below section of this page.
and Group 'D' posts. Interested Candidates who get hired for the offered SSC CGL Vacancies can apply by submitting online application form on or before last date. Rest details about SSC CGL Application Form Notification such as qualification, application fee, how to apply etc are well equipped in the below section of this page.
If you want to really apply, ready to yourself complete your all certificates like as mark sheets, age proof, cast certificate, income certificate etc because these need will be before submit online application form. This is really a great opportunity for all those candidates who wanted to secure their career in government sector. CGL exam registration will be in two parts (Part 1 online registration & Part 2 Online registration). In such part applicants will apply very carefully, before submit all acknowledgements in each part please double check your application form and then proceed to submit button.
Every year SSC – Staff Selection Commission operates several examinations to select promising and responsible applicants for various nil seats. SSC conducts the most popular examination named CGL – Combined Graduate Level exam in the month of August. The registration of SSC CGL perhaps will start from February so you may register yourself for this examination after announce of notice via official site (www.ssc.nic.in) in order to apply for it. There few eligibility criterions which must be full filled in order to apply for this recruitment examination.
SSC CGL Application Form Complete Details
Offered Positions: Gigantic numbers of contenders apply every year for the Staff Selection Commission Vacancies, some of which are given below -
- Inspector (Examiner)
- Inspector
- Inspector of Income Tax
- Inspector (Central Excise)
- Inspector (Preventive Officer)
- Auditors
- UDCs
- Tax Assistants
- Junior Accountant & Accountant
- Sub-Inspector (CBN)
- Assistant Enforcement Officer
- Inspector (CBN) Compiler
- Divisional Accountant & others
SSC CGL Notification Overview
Eligibility Criteria:
- All applicants must have a Graduate Degree in the concerned specialty as per the offered position from a reputed board or university.
- Applicants those who want to apply their age must be in between 18-27 years. There will be age relaxation in upper age limit for deserving category appliers as per the govt norms.
Application fee:
- Applicants who are going to apply for SSC CGL posts they will have to remit an amount of Rs. 100/-.
- Reserved category candidates are exempted for the payment of fee.
Selection Procedure: Applicants who want to get selected for the offered positions by SSC CGL must have to qualify the written examinations for different various jobs.
Preparation Tips for Exams – Read Now
SSC CGL Dates:
How to apply? Candidates who meet the eligibility criteria may apply for SSC CGL by filling online application form through following the steps tuned below.
- CGL Online Registration Starting Date - February
- CGL Registration Closing Date - March
- CGL Exam Date - May
How to apply? Candidates who meet the eligibility criteria may apply for SSC CGL by filling online application form through following the steps tuned below.
- Firstly, candidates need to Visit official website of the SSC which is www.ssconline.nic.in.
- On home page, move the cursor on 'Recruitment' section and press on the suitable link as per the position for which you want to apply.
- Now hit on 'Apply online' and Read the admission details and eligibility criteria carefully before starting your application process.
- Now start filling online application form carefully with all asked details.
- Upload recent passport size photograph and make payment of Fee.
- After completing online application submit it within given time period.
- After you have completed form and made payment, you will get a unique application ID for future reference.
How to Fill Application Form Online – See Now
Note: To check the other details candidates may visit the official link.
- SSC CGL Admit Card ->> Full Details
- SSC CGL Syllabus ->> Full Details
- SSC CGL Answer Key ->> Full Details
- SSC CGL Result ->> Full Details
- SSC CGL Online Registration ->> Full Details
SSC CGL Updates & Preparation Material
About SSC: The Estimates Committee of the Parliament, in its 47th Report nineteen sixty seven- sixty eight (1967-68), recommended the setting up of a Service Selection Commission (SSC) for conducting examinations for employment to lower categories of Posts. Pursuant to this, and as an interim measurement, an Examination Wing was initially added to the Secretariat Training School, subsequently renamed as the Institute of Secretariat Training and Management (ISTM). The Administrative Reforms Commission, in its Report on Personnel Administration, drew attention to the fact that bulk of the staff of the Govt. at the Centre and in the States belonged to Class third (III) and Class fourth (IV) categories.
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Although cigarette smoking is the major cause of chronic obstructive pulmonary disease (COPD), only a subset of smokers develops this disease. There is significant clinical, radiographic, and pathologic heterogeneity within smokers who develop COPD that likely reflects multiple molecular mechanisms of disease. It is possible that variations in the individual response to cigarette smoking form the basis for the distinct clinical and molecular phenotypes and variable natural history associated with COPD. Using the biologic premise of a molecular field of airway injury created by cigarette smoking, this response to tobacco exposure can be measured by molecular profiling of the airway epithelium. Noninvasive study of this field effect by profiling airway gene expression in patients with COPD holds important implications for our understanding of disease heterogeneity, early disease detection, and identification of novel disease-modifying therapies.
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. In the United States, COPD caused 127,000 deaths in 2005 (1), and the burden of disease is expected to increase in the coming decades (2). Although cigarette smoking is a well-established cause of COPD, it is unclear why only a subset of smokers develops this disease. Although cigarette smoking is a leading cause of COPD, smoking cessation is not uniformly effective at halting disease progression. Current therapies for COPD are effective for symptom reduction (3–5) and may slow the rate of decline of FEV1 (3), but they do not arrest the longitudinal decline in lung function or decrease mortality (3–5).
Among smokers who develop COPD, the natural history is highly variable (6). This variability may be due to the diverse clinical, pathologic, and radiographic manifestations of this disease within and across individuals. Although spirometry detects the irreversible airflow obstruction characteristic of COPD (6), it does not quantify the alveolar septal destruction, airway wall thickening, or small airway inflammation associated with the disease (7–9). The variable natural history of COPD could be the result of diverse pathogenic mechanisms involving distinct patterns of molecular deregulation. The distinct clinical and molecular phenotypes associated with COPD could in turn be the result of heterogeneity in the physiological response to tobacco smoke exposure.
In this article, we review the smoking-induced field of injury in the airway, its applications to smoking-induced airway disease, and the implications this holds for understanding of distinct molecular phenotypes of COPD, molecular pathogenesis, and disease-modifying therapies.
Cigarette smoking creates a molecular field of injury throughout the airways and lung. Although this field effect was first observed in smokers with head and neck cancers (10), it has subsequently been described in smokers with and without lung disease. This field effect includes p53 mutations (11), EGFR mutations (12), loss of heterozygosity (13), microsatellite alterations (14), and mutations in mitochondrial DNA (15). Several groups have described epigenetic alterations in the smoking-induced airway field of injury, including increased telomerase activity (16) and alterations in methylation of p16 (17). These changes extend into the oral epithelium of the upper airway (18, 19).
Although several theories of the origin of this field effect have been proposed (20), a substantial portion likely reflects an individual's physiologic response to tobacco exposure. Because this response is likely to result in modulation of gene expression patterns in tobacco-smoke–exposed tissues, our group and others have hypothesized that profiling of the airway transcriptome may provide a detailed characterization of an individual's specific physiologic response to tobacco smoke. Because this response likely contributes to smoking-related disease pathogenesis, airway transcriptome profiling may provide an opportunity for the characterization of relatively easily accessed tissues in the airway to provide diagnostic and prognostic information about the presence of smoking-induced disease as well as disease risk.
Our group and others have shown that smoking induces large-scale gene expression changes in the airway. Smoking-induced alterations in gene expression occur in the intrathoracic large- and small airway epithelium (21, 22, 41) and in the extrathoracic airway epithelium of the nose and mouth (23) (Table 1). These alterations in airway gene expression result in changes in the corresponding proteins in the bronchial airway epithelium (24). The airway expression of regulatory miRNA is also altered by smoking, and these changes contribute to the regulation of specific smoking-modulated mRNAs (25) (Table 1).
Many of the genes that are altered by smoking code for proteins with functions involved in inflammation and oxidative stress, suggesting that a large component of the physiologic response to smoking is involved in antioxidant defense and detoxification of a number of the components of tobacco smoke. Consistent with this hypothesis, the majority of these alterations in gene expression are rapidly reversible upon smoking cessation, suggesting that their alteration by smoking represents an acute response to the toxic effects of inhaled cigarette smoke (26, 27). In addition to genes that are rapidly reversible upon smoking cessation, a subset of the genes that are altered by smoking are only slowly reversible or are altogether irreversible after smoking cessation. Such aspects of the physiologic response to smoking might form the basis of the continued risk for smoking-induced lung disease among former smokers (Table 2) (26).
Lung cancer, like COPD, is a smoking-related disease for which former smokers remain at elevated risk long after smoking cessation and for which heterogeneous responses to cigarette smoke presumably contribute to the development of disease. The airway field of injury hypothesis thus suggests that a detailed profile of the airway transcriptome may be able to distinguish individuals with lung cancer or individuals at risk for lung cancer from healthy smokers and former smokers, thereby providing a clinically useful tool for a disease that lacks effective early diagnostic strategies.
Our group has profiled gene expression in cytologically normal bronchial airway epithelium samples obtained from smokers undergoing bronchoscopy for suspicion of lung cancer. We have developed an 80-probeset signature that can serve as a sensitive and specific early diagnostic biomarker for lung cancer (28). The performance of this biomarker improves when used in combination with clinical features such as patient age, mass size, and lymphadenopathy (29), suggesting that the molecular information measured by the biomarker is independent of other recognized lung-cancer risk factors. In cases where clinical assessment by independent physicians was most uncertain about the likelihood of lung cancer, this combined clinicogenomic model improved the diagnostic accuracy, suggesting that this approach might facilitate the diagnostic evaluation of smokers suspected of having lung cancer when clinical uncertainty exists (29). A quantitative competitive reverse transcription PCR–based biomarker has also been developed by other groups, which similarly enhances diagnostic accuracy in cytologically nondiagnostic specimens (30).
Using airway biomarker development in lung cancer as a model, expression-based COPD biomarkers should be developed for disease screening, early disease detection, molecular classification, and prognostication. Although there are several studies of gene expression in the lung tissue of patients with COPD (31), there are few studies of gene expression in more readily accessible airway tissue and none that link COPD-specific changes in airway gene expression to the lung.
In the first study of the airway transcriptome in COPD, Pierrou and colleagues compared whole-genome expression profiling of bronchial brushings from 38 subjects with COPD, 18 healthy smokers, and 14 healthy nonsmokers (32). They compiled two lists of oxidative response genes, one generated from mining the literature and one generated based on protein sequence domains. They demonstrated enrichment of these oxidative response genes among genes that change in smokers and smokers with COPD (Table 1) and enrichment of binding sites for nuclear factor-κB, Nrf2, FOXO4, and several other transcription factors in the promoter regions of these oxidative response genes (32).
Small airway gene expression in COPD has also been examined using expression profiling of brushings obtained from tenth- to twelfth-generation bronchi of 13 smokers with COPD, 15 healthy smokers, and 20 nonsmokers. After defining a list of genes involved in Notch signaling using literature mining, Tilley and colleagues demonstrated down-regulation of genes in the Notch pathway among smokers with COPD (33) (Table 1). The relationship between COPD-associated gene expression changes in the small airways and those described in the large airway (32) remains unclear.
Additional studies that follow patients longitudinally are required to identify expression profiles associated with longitudinal lung function decline and disease progression. Examination of airway tissues that can be collected noninvasively is particularly well suited for such longitudinal studies, given the difficulty of obtaining serial lung tissue samples. Current studies have also been limited to subjects whose COPD has been characterized by spirometry only. Although this is the current clinical standard (6), complete histopathologic and radiographic classification of parenchymal destruction, airway wall thickening, and small airways inflammation, coupled with genome-wide gene expression studies to identify gene-expression correlates of these phenotypes, might facilitate a deeper understanding of the mechanisms that contribute to these known sources of clinical heterogeneity.
Combining airway epithelial expression profiling of patients with COPD with detailed clinical, radiographic, and histologic phenotyping will elucidate the relationship between gene expression patterns and clinical subtypes. Similar to a previous study of lung adenocarcinoma (34), variability in gene expression among patients with COPD can be used to identify novel molecular subclasses of this disease.
COPD-associated patterns of gene expression changes in lower airway can be extended to the upper airway. This would facilitate disease screening and might allow detection of early disease not apparent by spirometry. Examination of upper airway gene expression might also allow the development of an expression-based, noninvasive biomarker for COPD risk.
Alterations in airway gene expression in COPD could be used to monitor response to therapy. As in a previous study of inhaled corticosteroids in patients with asthma (35), a biomarker for therapeutic response could be developed for patients with COPD. By understanding the specific profile of airway genes altered in COPD, novel therapies could be quickly screened by looking for reversal of the disease-associated gene expression pattern.
Finally, beyond characterizing airway gene expression changes that occur in COPD, it is important to explore the mechanisms by which these alterations occur. As with smoking and smoking-associated lung cancers, genetic susceptibility and epigenetic modifications might explain some of the alterations in airway gene expression in COPD. Several candidate genetic risk factors have been identified in genome-wide association studies of COPD (36–39). Bronchial biopsies from patients with COPD have decreased histone deacetylase activity and, unlike bronchial biopsies from patients with asthma, have no change in histone acetyltransferase activity (40). Integration of transcriptomic profiling with whole-genome microRNA, methylation, and genotyping studies in the airway will ultimately provide a comprehensive view of the molecular field of injury associated with COPD.
Supported by NIH/NHLBI grant R01 HL095388-01 (A.S., M.E.L.) and by an American Thoracic Society Fellow Career Development Award (K.S.).
Conflict of Interest Statement: None of the authors has a financial relationship with a commercial entity that has an interest in the subject of this manuscript.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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