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Although global hypomethylation of leukocyte DNA has been associated with an increased risk of several sites of cancer, including breast cancer, determinants of global methylation level among healthy individuals remain largely unexplored. Here, we examined whether postmenopausal endogenous sex hormones were associated with the global methylation level of leukocyte DNA.
A cross-sectional study was conducted using the control group of a breast cancer case–control study in Nagano, Japan. Subjects were postmenopausal women aged 55years or over who provided blood samples. We measured global methylation level of peripheral blood leukocyte DNA by luminometric methylation assay; estradiol, estrone, androstenedione, dehydroepiandrosterone sulfate, testosterone and free testosterone by radioimmunoassay; bioavailable estradiol by the ammonium sulfate precipitation method; and sex-hormone binding globulin by immunoradiometric assay. A linear trend of association between methylation and hormone levels was evaluated by regression coefficients in a multivariable liner regression model. A total of 185 women were included in the analyses.
Mean global methylation level (standard deviation) was 70.3% (3.1) and range was from 60.3% to 79.2%. Global methylation level decreased 0.27% per quartile category for estradiol and 0.39% per quartile category for estrone while it increased 0.41% per quartile category for bioavailable estradiol. However, we found no statistically significant association of any sex hormone level measured in the present study with global methylation level of leukocyte DNA.
Our findings suggest that endogenous sex hormones are not major determinants of the global methylation level of leukocyte DNA.
DNA methylation, which is one type of epigenetic change, may play an important role in carcinogenesis by silencing tumor suppressor genes through hypermethylation or by activating oncogenes through hypomethylation [1]. In addition to gene-specific DNA methylation, global DNA hypomethylation in regions that are normally methylated, such as repeats or transposable elements, can also lead to genomic instability and altered gene transcription, and thereby affect the normal growth and differentiation of target tissues [1,2]. Although the majority of methylation studies to date have focused on localized hypomethylation and hypermethylation of specific genes in tumors [3,4], several epidemiological studies have examined the global methylation level of peripheral blood DNA, which is considered a potential surrogate biomarker for systemic genome methylation status [5-9]. In consequence, global hypomethylation of leukocyte DNA has been associated with an increased risk of several sites of cancer, including breast cancer [5,6,8]. However, determinants of global methylation level among healthy individuals have remained largely unexplored, although a number of genetic and environmental factors are thought to influence the level of DNA methylation [10].
Given that global hypomethylation has been associated with an increased risk of breast cancer [8], as well as the important role of endogenous sex hormones in the etiology of breast cancer, particularly estrogens [11-13], we hypothesized that endogenous sex hormone level might be a determinant of the global methylation level of leukocyte DNA. Clarification of the association between sex hormones and global DNA methylation level may contribute to a better understanding of the etiology of breast cancer.
In the present study, we tested the hypothesis based on a cross-sectional study of postmenopausal Japanese women.
Subjects were postmenopausal women who participated as controls in a multicenter, hospital-based case–control study of breast cancer conducted from May 2001 to September 2005 at four hospitals in Nagano Prefecture, Japan. Details of this study have been described previously [14,15]. The study protocol was approved by the institutional review board of the National Cancer Center, Tokyo, Japan.
Briefly, the case subjects were a consecutive series of women aged 20–74years with newly diagnosed, histologically confirmed invasive breast cancer who were admitted to one of the four hospitals during the survey period. Of the 412 eligible patients, 405 (98%) agreed to participate. Healthy controls were selected from medical checkup examinees at two of the hospitals and confirmed to not have any cancer. They were matched with one case subject each by age (within three years) and residential area during the study period. Among potential control women, one declined to participate and two refused to provide blood samples. Consequently, written informed consent was obtained from 405 matched pairs.
Of 405 control women, we selected postmenopausal women aged over 55years who provided blood samples and reported an energy intake between 500 and 4000kcal. The present study included a total of 185 women.
Participants were asked to complete a self-administered questionnaire which included questions on demographic characteristics, anthropometric factors, smoking habit, family history of cancer, physical activity, medical history, and menstrual and reproductive history. Dietary habits were investigated using a 136-item semi-quantitative food-frequency questionnaire (FFQ) which was developed and validated in a Japanese population [16,17]. In the FFQ, participants were questioned on how often they consumed individual food items (frequency of consumption), as well as relative sizes compared to standard portions. Daily food intake was calculated by multiplying frequency by standard portion and relative size for each food item in the FFQ. Daily intakes of nutrients were calculated using the fifth revised and enlarged edition of the Standard Tables of Food Composition in Japan [18]. The FFQ included questions on supplement use, but nutrient intake from supplements was not included in the analyses because no comprehensive database for supplements was available. Any influence is assumed to be minimal, however, because none of the present subjects used folate supplementation and only eight subjects (4.3%) used vitamin B supplementation. We previously documented that the questionnaire's assessments of folate intake, and vitamin B2, B6, and B12 intake were reasonably valid [14,17].
Participants provided blood samples at the time they returned their self-administered questionnaire. Whole blood in 7-mL EDTA-2Na vacutainers and serum samples were stored at −80°C until analysis.
Details of hormone assays have been described previously [19]. Briefly, we measured estradiol, estrone, androstenedione, dehydroepiandrosterone sulfate (DHEAS), testosterone, and free testosterone in serum by radioimmunoassay. Bioavailable estradiol (free and albumin-bound estradiol) was measured by the ammonium sulfate precipitation method. Sex-hormone binding globulin (SHBG) was measured by immunoradiometric assay. Lower detection limits (LODs) were 5pg/mL for estradiol, 15pg/mL for estrone, 6.25nmol/L for SHBG, 0.1ng/mL for androstenedione, 5 ug/dL for DHEAS, 0.05ng/mL for testosterone, and 0.4pg/mL for free testosterone. Measurement values below the LOD were assigned half the value of the LOD if measurable values below the LOD were not available. Intra-assay coefficients of variation (CV) were 6.5% for estradiol at a mean concentration of 24.9pg/mL (n=12), 10.6% for bioavailable estradiol at a mean level of 48.1% (n=10), 5.6% for estrone at a mean concentration of 101.7pg/mL (n=10), 4.7% for SHBG at a mean concentration of 104.6nmol/L (n=10), 9.4% for androstenedione at a mean concentration of 1.33ng/mL (n=10), 5.2% for DHEAS at mean concentration of 75 ug/dL (n=10), 4.5% for testosterone at a mean concentration of 0.83ng/mL (n=10), and 11.6% for free testosterone at a mean concentration of 5.4pg/mL (n=10). A commercial laboratory performed all hormone assays and provided information on intra-assay CVs (Mitsubishi Kagaku Bio-Clinical Laboratories, Tokyo, Japan).
Genomic DNA was extracted from the peripheral blood using a Qiagen FlexiGene DNA Kit (Qiagen, Hilden, Germany) according to the manufacturer's protocol.
Global DNA methylation was quantified by LUMA (LUminometric Methylation Assay) [20,21]. Three hundred nanograms of Genomic DNA were cleaved with HapII+EcoRI or MspI+EcoRI in two separate 20-μl reactions containing 2μl of 10×T buffer (330mM Tris-acetate, 100mMMg-acetate, 660mMK-acetate, 5mM dithiothreitol), 2μl of 0.1% BSA, and 5 units of each of the restriction enzymes. The reactions were set up in a PSQ 96 Plate Low (Qiagen) and incubated at 37°C for 1h. Then, 20μl of annealing buffer that contained 200mM Tris-acetate and 50mMMg-acetate pH 7.6 was added to the cleavage reactions, and samples were assayed using PSQ96 MA system (Biotage AB, Uppsala, Sweden). The instrument was programmed to add dNTPs in six steps, including Step 1, dATPαS; Step 2, mixture of dGTP+dCTP; Step 3, dTTP; Step 4, mixture of dGTP+dCTP; Step 5, water; and Step 6, dATP. Peak heights were calculated using the PSQ96 MA software. HapII/EcoRI and MspI/EcoRI ratios were calculated as (dGTP+dCTP)/dATP for each reaction. The HapII/ MspI ratio was then calculated as (HapII/EcoRI)/(MspI/EcoRI), which corresponds to the proportion of unmethylated CCGG. Restriction enzymes (HapII, MspI, and EcoRI) were purchased from Takara Bio (1053A, 1150A and 1040A, respectively; Shiga, Japan). PyroMark Gold Q96 Reagents for pyrosequencing were purchased from Qiagen (972804). DNA quantification was performed using the Quan-iT PicoGreen dsDNA Reagent and kit (P7581, Invitrogen, CA, USA). Intra-assay CV was 6.4% at a mean level of 74% (n=20).
Five polymorphisms in methylenetetrahydrofolate reductase (MTHFR) (rs1801133 and rs1801131), methionine synthase (MTR) (rs1805087), and methionine synthase reductase (MTRR) (rs10380 and rs162049) were genotyped by TaqMan SNP Genotyping Assays developed by Applied Biosystems (Foster City, CA). Genotype frequencies were tested for deviation from the Hardy–Weinberg equilibrium with the χ2-test as quality control for genotyping (all P values>0.05).
Hormone levels were divided into median or quartile categories. Adjusted mean global methylation levels of leukocyte DNA according to endogenous sex hormone levels were calculated using a multivariable liner regression model. To test linear trends for mean hormone levels, regression coefficients (β) were calculated in the multivariable linear regression model using median or quartile categories of individual hormone levels as ordinal variables. We performed the initial analyses with age-adjustment. In multivariate model, the following variables were used for adjustment: age, family history of breast cancer, history of benign breast disease, age at menarche, age at menopause, number of births, age at first birth, height, body mass index (BMI), smoking status, alcohol drinking habit, physical activity in the past five years, and energy-adjusted folate intake, most of which are known as potential breast cancer risk factors [11,12]. Dietary folate intake was adjusted for total energy intake with the use of the residual method [22,23]. To investigate potential effect modification, subgroup analyses were performed by dietary and genetic factors related to one-carbon metabolism and tests for interaction were carried out. All P values reported are two-sided, and significance level was set at P<0.05. All statistical analyses were performed with SAS software version 9.1 (SAS Institute, Inc., Cary, NC).
Mean age (standard deviation [SD]) among the total of 185 women was 62.8 (5.7) years old and mean BMI (SD) was 23.4 (2.9) (Table (Table1).1). Measurement of global methylation levels of leukocyte DNA and endogenous sex hormone levels was completed in 185 women. Mean global methylation level (SD) was 70.3% (3.1) and range was from 60.3% to 79.2% (Table (Table2).2). The proportion of women with levels below the LOD were 1.6% for estradiol, 6.5% for estrone, 0% for bioavailable estradiol and SHBG, 0.5% for androstenedione and DHEAS, 41% for testosterone, and 95% for free testosterone. Because of the high percentage of women with levels below the LOD, we did not use free testosterone in the present analyses. Women with estrone values>125pg/mL, estradiol values>75pg/mL, or testosterone values>125ng/dL are suspected to use postmenopausal hormones but none of our present women met the above conditions.
Mean global methylation levels according to endogenous sex hormone levels are shown in Table Table33 and Figure Figure1.1. In the age-adjusted model, a higher level of estrone was significantly associated with a lower level of global methylation (0.45% decrease per quartile category, p=0.03) but no statistically significant association was observed for other sex hormones (data not shown in Table). In the multivariate model we did not find a statistically significant association between any sex hormone level measured in the present study and the global methylation level of leukocyte DNA. However, higher levels of estradiol, estrone, androstenedione, DHEAS, and testosterone were associated with a lower level of global methylation while a higher bioavailable estradiol level was associated with a higher level of global methylation. Global methylation level decreased 0.27% per quartile category for estradiol (p=0.20) and 0.39% per quartile category for estrone (p=0.06) while it increased 0.41% per quartile category for bioavailable estradiol (p=0.06). We further calculated regression coefficients per unit using a continuous variable of individual natural log-transformed hormone levels. The borderline statistically significant associations for estrone and bioavailable estradiol disappeared (p=0.15 for estrone and p=0.20 for bioavailable estradiol) and none of the associations were statistically significant (data not shown in Table).
We performed subgroup analyses of associations between sex hormone level and global methylation level by alcohol drinking status and folate intake (Table (Table4).4). A higher DHEAS level was significantly associated with a lower level of global methylation among alcohol-drinking women (0.78% decrease per quartile category), whereas no association was observed among non-drinkers (0.11% increase per quartile category) (P for interaction=0.03). No statistically significant interaction was observed for other sex hormones, however. We further performed subgroup analyses by vitamin B2, B6, and B12, and five polymorphisms in MTHFR, MTR, and MTRR but found no statistically significant interaction (data not shown).
In this cross-sectional study among postmenopausal Japanese women, we found no statistically significant association between endogenous sex hormone level and the global methylation level of peripheral blood leukocyte DNA. To our knowledge, this is the first study to test the hypothesis that endogenous sex hormones are potential determinants of the global methylation level of leukocyte DNA. Our findings did not support this hypothesis, however, and suggest that endogenous sex hormones might not be major determinants.
Many epidemiological studies have confirmed the important role of endogenous sex hormones, particularly estrogens, in the etiology of breast cancer [11,12]. A pooled analysis of nine prospective studies showed that higher estrogens and their androgen precursors were associated with a higher risk of breast cancer in postmenopausal women [13]. In addition, several well-known risk factors have also implicated an etiologic role of sex hormones, including age at menarche and menopause, parity and age at first birth, and BMI [11]. Recently, Choi et al.. reported that global hypomethylation was associated with an increased risk of breast cancer [8], suggesting that the global methylation level of leukocyte DNA plays a role in the etiology of breast cancer. However, our findings suggest that global methylation level does not serve as a surrogate marker for the level of endogenous sex hormones and that the mechanisms by which global hypomethylation increases the risk of breast cancer might involve non-hormonal factors.
Several possible explanations for the observed absence of associations can be considered. First, misclassification due to inaccurate measurement may have attenuated the true association. However, since the reproducibility of assays for global methylation and sex hormone levels were relatively high, with an intra-assay CV for global methylation of 6.4%, and a range for hormones from 4.5% for testosterone to 10.6% for bioavailable estradiol, the absence of associations was unlikely due to measurement error. On the other hand, global methylation level might be affected by differences in the proportion of white blood cell types. Indeed, Zhu et al.. reported that the proportion of neutrophils and lymphocytes among white blood cell types modified LINE-1 methylation levels measured in blood DNA [9]. In the present study, since we measured global methylation level on white blood cells by the LUMA method, the possibility of measurement error due to different proportions of white blood cell types cannot be excluded. Such misclassification might accordingly have attenuated the true association, which might in turn have explained our results, at least in part. Second, the single time point measurement of serum hormone levels might not have captured the overall activity of the sex hormone-related signaling pathway of the subject up to the age of study. Third, although the present study included a total of 185 women, it may not have had sufficient statistical power to detect small associations.
Differences in assessment methods of global DNA methylation require consideration. While several previous studies estimated global DNA methylation based on data restricted to repetitive DNA elements, such as Alu and LINE-1 [7,8], the present study used LUMA, which allows the estimation of genome-wide DNA methylation levels. Differences in assessment methods might therefore have affected study results. For example, Choi et al.. found that global hypomethylation of leukocyte DNA measured by 5-methyldeoxycytosine (5-mdC) was associated with an increased risk of breast cancer but saw no association with the LINE-1 methylation level of leukocyte DNA [8]. Similarly, Wischwendter et al. reported no association between the Alu methylation level of leukocyte DNA and breast cancer risk [7].
The mechanisms by which endogenous sex hormone levels might affect global methylation status have not been elucidated. However, there is some evidence that estrogens or endocrine disruptors might alter DNA methylation status [24-26]. Studies in mice have shown that neonatal exposure to diethylstilbestrol (DES), a synthetic non-steroidal estrogen, induced hypomethylation of estrogen-responsive lactoferrin gene and proto-oncogene c-fos in utero [24,25]. Another study showed that exposure to persistent organic pollutants such as polychlorinated biphenyls, many of which are known endocrine disruptors, was associated with global DNA hypomethylation in Greenlandic Inuit [26].
In our subjects, subgroup analyses suggested that alcohol drinking modified the association between endogenous sex hormone levels and the global methylation level of leukocyte DNA: higher DHEAS was significantly associated with a lower level of global methylation among alcohol drinkers, whereas no association was observed among non-drinkers. Since alcohol consumption interferes with folate metabolism [27] and decreases levels of serum folate [28], our findings might indicate that higher sex hormone levels were associated with a lower level of global methylation among subgroups with a low folate status only. This hypothesis, however, does not appear to be supported by our subgroup analyses by folate intake or MTHFR polymorphisms (rs1801133 and rs1801131). Although the T allele of MTHFR (rs1801133) and C allele of MTHFR (rs1801131) have shown lower enzyme activity [29,30], no remarkable difference in global methylation level was observed among genotypes of MTHFR. These inconsistent findings might be explained by multiple comparisons, insufficient power, or the possibility that alcohol consumption interacts with sex hormone levels via a mechanism other than the folate-related metabolism. In any case, the findings of our subgroup analyses should be interpreted with caution, and further research to clarify effect modification by dietary and genetic factors related to one-carbon metabolism on the association between sex hormone level and global methylation level is clearly required.
In this cross-sectional study among postmenopausal Japanese women, we found no statistically significant association between endogenous sex hormones and the global methylation level of leukocyte DNA. Although the interpretation should be limited to postmenopausal women, our findings suggest that endogenous sex hormones might not be major determinants of the global methylation level of leukocyte DNA and that mechanisms by which global hypomethylation increases the risk of breast cancer might involve non-hormonal factors. A comprehensive understanding of the determinants of the global methylation level of leukocyte DNA and the role of this level in the etiology of breast cancer awaits further study.
BMI, body mass index; CV, coefficient of variation; DES, diethylstilbestrol; DHEAS, dehydroepiandrosterone sulfate; FFQ, food frequency questionnaire; LOD, lower detection limit; LUMA, LUminometric Methylation Assay; MTHFR, methylenetetrahydrofolate reductase; MTR, methionine synthase; MTRR, methionine synthase reductase; SHBG, sex-hormone binding globulin.
The authors declare that they have no competing interests.
All authors were involved with the study concept and design. MI, YK, SY, HO, HN, RK, and ST participated in the acquisition of data. HO and TY measured global DNA methylation level and genotyping. MI, HO, AK, TY, and ST contributed to the analysis and interpretation of data. MI and AK conducted the statistical analyses and MI wrote the manuscript. All authors participated in the interpretation of results and critical revision of the manuscript for important intellectual content. All authors read and approved the final manuscript.
The pre-publication history for this paper can be accessed here:
We thank Dr. Hiromi Sakamoto for her helpful advice on DNA methylation assay. We also thank Ms' Yoko Odaka and Misuzu Okuyama for technical assistance.
This study was supported by Grants-in-Aid for the Third Term Comprehensive Ten-Year Strategy for Cancer Control and for the Research on Applying Health Technology from the Ministry of Health, Labor and Welfare of Japan; by the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation (NIBIO), by Grants-in-Aid for Scientific Research on Priority Areas (17015049), and for Scientific Research on Innovative Areas (221S0001), and for Young Scientists (B) (22700934) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and the Japan Society for the Promotion of Science, and by Foundation for Promotion of Cancer Research in Japan.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Listing information
- Year Built: 2010
- Status: Sold on 3/3/1995
- Parking Type Description: Attached 2 cars
- Below Ground Sq. Feet: 1,220
- School District: Shenendehowa
- Property ID: 103951626
- Beds: 4
- Total Rooms: 10
- New Construction: No
- Lot Area: 0.60
- Style: Custom
- Baths: 3 (Full: 2 3/4: 0 1/2: 1 Other: 0)
- Fireplaces: 1
- Total Square Footage: 2,482 ($85.41 per sq. foot)
- County: Saratoga
Age Description Actual
Amenities Atrium Door, Ceramic Tile, Crown Molding, Vaulted Ceiling, Wood Floors
Appliances Cook Top W Grill, Dishwasher, Disposal, Microwave, Range W Oven
Attic Hatch, Part
Basement Full
Condition Superior
Cooling Type Central Air
Exterior Cedar
Exterior Features Deck, Supplemental Well
Garage Description Attached
Heat Fuel Natural Gas
Heat System Hot Air
Interior Features Cable Hook Up, Garage Door Opener, Paddle Fan, Sump Pump, Water Softener
Lot Description Dead End, Level
Other Fuel Cost - 150/Mo, Model - Cust Trad, Possession - Immediate
Roof Asphalt Shingle
Sewer Public
Sign Yes
Total Taxes Description Actual
Water Public
Dining Room Main Level
Family Room Main Level
Kitchen Main Level
Living Room Main Level
REC RM Basement
STUDY Basement
Bedroom 2nd Level
Bedroom 2nd Level
Bedroom 2nd Level
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Listed by Suzanne Dingley of Coldwell Banker Prime Properties

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Picture: Avril Lavigne Maxim's 8th Annual Hot 100 Party hosted by Maxim Magazine held at The Hotel Gansevoort - Arrivals New York City, USA - 16.05.07
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Executives at the I'M WITH YOU singer's record company had been trying to keep the romance under wraps.
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If you weren't able to make it to our live recording this past Saturday, Drunken Musings #10 is now posted for your listening pleasure. In this episode we covered our weeks in WoW, and I told some stories of things that happened to me in the past few weeks. Raset has been streaming a lot recently, and I hang out in his channel quite often, you can find him over at twitch.tv/goblinraset, which is the channel you want to follow if you want to know when our podcast recordings go live! Other than that we cover some WoD news as well as take note of TSM Lead Developer Sapu's AMA (Ask Me Anything) that took place on reddit last Sunday (a week before yesterday). Definitely check that out as well, very interesting responses! New post up tomorrow, kind of summing up the ticket I had sent for my most recent Scam'd post and some ways to interface with Blizzard for quick and accurate results. Until then,
Phat Lewts


text: Right fellas the prices are in for the DSG pedals. Not a massive saving over the Vag -parts prices but at least they are within budget. Accel Pedal and brake will be £53.99 +P&P I'm assuming they will be able to be sent via special next day delivery insured for £5.20 So the total is under £60. For those that are interested still please let me know. To keep prices down I'd like to only accept cash either by direct bank transfer or cheque (direct transfer is easier for me!) I can accept paypal but the charges would have to be passed onto yourselfs! As the items come boxed the packing is going to be next to nothing. I live in southampton and work in Basingstoke/Newbury and guildford so it would be possible for you to collect if you are local to any of those areas. The manual pedal prices are still coming - hopefully.... J.


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Anna Shirley
"A little nonsense now and then, is cherished by the wisest men."
Anna comes from a family rich in the foundations of linguistics, from sign language to subtitling, and counts mathematics as merely another language. She attended a school that specialised in languages, going on to read French and Italian at Leeds University, although she convinced her tutors that time abroad was advantageous and spent most of her time in Verona and Dijon. After graduating with a First Class degree Anna joined a large international translation organisation, editing, translating and copywriting. It was when leading a project to edit and translate a series of search campaigns that she was introduced to PPC, and after 6 months of independent research she chose to move industries.
Anna is involved in many of our European foreign language campaigns. She's vegetarian and a keen yogi and is the person you chat to if you are struggling with a tricky bit of ad copy. Should you speak to Anna please ask how her jellyfish sting was treated!
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I don't know. Very inexperienced. Last season they lost seven games in a row and he needed to call in the help of Dick Advocaat as adviser. He doesn't seem like the most gifted tactical manager either (Advocaat f.e. said how easy it was too dismantle Feyenoord when they played Fenerbachce in Europe). He also seems like a very mellow person. Too mellow for this high profile job maybe (english press mostly)? I don't know him personnally, I could be wrong about that. Feyenoord is a big job too, but as a kid of the club he has more credit with the fans etc.
Wouldn't mind giving him a chance though in a couple of years, very likeable guy. Not a particulary good argument to want someone, but still .
Van Bronckhorst and Feyenoord are currently taking a massive step towards their first title since 1999. I'd be really glad for him if they win the last two games too.
Feyenoord real close to clinching their first league title since 98/99.
Eredivisie has 34 games
Feyenoord play a derby away to Excelsior placed 13th, with nothing to play for. Ajax at home to already relegated Go Ahead Eagles, rock bottom. It is expected Feyenoord will easily win today though.
Matches have just kicked off. All at the same time.
Feyenoord losing 3-0 .. Fortunately for them they will have another chance to win the league at home against Heracles Almelo.
(hopefully they fail)
Hahahaa shambles
They only needed a fucking draw. This is their only chance to win it now and in the future. Ajax has got a better team already.
TIL Dirk Kuyt is still a footballer.
17 years after the last title?
Pretty awesome for Kuyt to score a hat trick in the last game of the season to win the title for Feyenoord for the first time in 18 years.
If ever there was a game to retire on, that is it.
congrats to Giovanni van Bronckhorst and Feyenoord
Finally, the first Wenger era player to successfully transition to management
With Kuyt scoring a hat trick at age 36 to win them the title. Fuckin Kuyt 🤣
Gutted for Ajax though. But, Feyenoord's first league title since 18 years.
Didn't see you posted the exact same 🤣
Ajax shouldn't be too gutted. They've a great young team that will regain the title in years to come. Grats to Feyenoord though
was useless for Liverpool but fair play to him, a hometown hero
I don't know, was he? He is one of those players awfully underestimated by fans because he isn't the most graceful player, but I think most managers value him a lot. Even at Liverpool at the time.
At least he runs and works hard.
Fucking Eboue!! Remember proper losing it after that. Such agony seconds after ecstacy
That was a fucking dive as well. Plus, remember Dalglish the twat telling Wenger to fuck off?


text: Hi guys, I wish my first post on here would have been under better circumstances, however I'm tearing my hair out right now and I just can't figure out what is wrong with my gimbal. On my first ever flight with the Typhoon G I noticed that the Gimbal wasn't reacting to my slider wheel inputs when I wanted to tilt the GoPro down. I brought it in to land and turned the Typhoon off and back on again. This time, because the tilt slider had been left all the way down, the Gimbal fired up and indeed tilted the GoPro down towards the ground... I tilted it back up using the slider and all was good, I carried on with the flight no issues. This then happened on my second flight a few days later. The gimbal does indeed keep the GoPro stabilised but wouldn't react to my tilt commands from the tx... power off and back on... it works fine for the rest of the flight. Today was the 3rd flight and it happened once again, however this time no matter how many times I powered down and back up the Typhoon the gimbal simply will not react to the tilt commands from the ST10+ transmitter slider. The Typhoon is on 1.07 FW and the ST10+ has been updated to the latest version from the Yuneec website. Any help would be very gratefully received.


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Ernie Banks 1963 Topps #380 Card Cubs
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Ernie Banks
1963 Topps #380 Card
We are doing a large consignment listing for a local gentleman that has a large number of cards. Most are 60's vintage. None have been graded. To our untrained dye they appear to be in good condition and w stored well ( typical of what you would expect to find in a shoe box in Granddad's closet).
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A/N: Another KakaSaku? Yep. This is a little one shot that I had festering around. I decided to take a break from ItachiKakashi fanfiction to write this piece. I have three other Naruto fics coming out. One is ItachiKakashi, the other is a funny drabble involving Sasuke and Naruto and the last is another KakaSaku fic.
Well enjoy!
Title: Acceptance
Author: Melissa Norvell
Rating: PG
Pairing: Kakashi X Sakura
Warning: Topic deals with depression; angst
Summary: ONE SHOT. KakaSaku. Kakashi is in a depression and Sakura tries to help him out, but what does Sakura say that she might take a turn for the two's relationship?
By: Melissa Norvell
She couldn't stand to see him like that anymore.
The silver haired jounin just sat there, looking depressed and down trodden. He would not speak for days, nor did he eat or even move. The forlorn form just remained there, like a statue frozen in time, no eminent life present within. No emotion. No vibrancy of any kind. Just stone cold with the heir of sadness hanging around him like a dark cloud.
Melancholy orbs of green stretched out over the lone figure, taking in the loneliness and depression that poured from the silver haired jounin. She knew there was something wrong. Recalling actions of the past, she knew that her teacher was never happy. She could see it in his lone, uncovered eye when he looked at his team and even in battle. No matter how much the silver haired Copy Ninja could mask it with an emotionless façade, there was always a sad heir about it.
When Sakura thought about it, there were few times she could recall her sensei ever being completely happy. He would make the occasional perverted joke, and at times, laugh casually at Naruto's remarks. The Copy Ninja also made a false happiness when in the presence of others.
But now it was just the two of them. Kakashi and Sakura, as teacher and student…
Or was it more then that now?
Those same green orbs have been locked on him since she was 12, always admiring him for his teachings and selflessness to risk his life for the sake of his team. Then again, Kakashi had always been hell-bent on that one ideal. Sakura had wondered what happened to him in the past to make him that way. He must have lost someone special to him.
'The names of my closest friends are etched upon this memorial stone.'
The young ninja remembered that phrase uttered by him upon her training as a genin. It was hard to believe that she had come such a long way. She was now 20 and a jounin, but during the last three years, she had become closer to Kakashi. He was no longer her teacher, but a comrade and friend.
It seemed as if he could be himself around her, even if himself consisted of a perverse, porn reading Shinobi. She never had to see his smile, to know that he was happy. His eye said it all, even without words. There was a certain shine within it's depths that signaled that he was content with her.
Deep within her swirl of emotions, she was happy to bring out that side of him. In ways, she had idolized him for hiding his emotions so well, through all situations. Even when Zabuza and Haku sacrificed themselves, and Naruto and she could not hold emotion well, Kakashi was back there being as stern as ever. Even if he at times seemed cold.
She knew it was all a façade to hide his true emotions. Through the Copy Ninja seemed simple enough to comprehend, in reality he was an intelligent and complex individual who remained shrouded in mystery.
But it was no mystery that he was sad and needed someone now.
It crushed her heart to see a long time team member and tutor in shambles and feeling helpless to aid him in his time of need. She knew that Shinobi weren't supposed to show true emotion, but perhaps, when he was all alone and his mind was falling the pit of black despair, he could let some of those emotions go. Keeping things in was bad for mental stability.
She could see that one eye, looking slightly out of it and unhappily downward, as if to concentrate on a sole piece of bacteria on the floor in front of him. The young woman wondered if he would have even noticed if she approached him.
Thinking that there was no time like the present, she took one uneasy step towards her teacher, inching towards him as her number of steps increased.
When she finally reached his form, she kneeled down and gently wrapped her arms around him from behind, brining him out of his deep contemplation. A masculine hand reached up to touch her forearms, wrapped snugly around his neck.
"Sakura?" His faint question reached the ears of the pink haired jounin.
"I just saw you looking sad over here, so I decided to come and sit with you. Sorry if I scared you, hope you don't mind my company." Sakura told him.
"No, not all." Kakashi felt a little better having Sakura there. Over the past three years the two of them developed a friendship that span long past a simple student and teacher relationship. He produced his false happy anime eye, but Sakura knew him better then that.
"You didn't look that happy before, Kakashi-sensei." She noted.
"Don't you think it's about time you dropped that honorific?" He asked casually. "We're both jounin now."
"Even if we are both jounin how, my knowledge of being a Shinobi would never compare to mine, and you'll always be the one who taught me everything I know." She smiled, moving to beside of him, sitting closely to him.
There was a small look of flattery from the older jounin shown through that depressed gaze.
The young woman was silent for a few minutes, as if she didn't want to say a sentence caught in her throat. The knew that if she didn't, Kakashi would use the Sharingan to ask her if she was thinking it, so she decided that now was better then never.
"I'll do anything to make you happy." The pink haired jounin told him in a wisp of a voice, so fragile in tone that it would be lost to the wind if you didn't listen closely.
A silver eye brow was arched in perverse contemplation. "Really?"
"Really." Sakura said in the same voice.
The silver haired man blinked, realizing that his comrade seemed very serious about it. He looked up at her face, which held a mix of emotions. She looked as if she were trying to hold back a tsunami of emotion within her.
It wasn't some perverted joke; she was being real about it.
Kakashi felt strange himself, confused at the simplest things about her and reading into deeper meaning of the words.
He pondered to himself for a few minuets, before his eye met with two eyes. Looking across from him, he gazed into fields of green, twisted in a brilliance of color and emotion as the sun danced around in a trance of mixed emotion, to a forbidden rhythm all it's own.
"Sakura…" Her sensei uttered in a confused and soft voice.
Softened green eyes looked back at him, almost as if tears would be released, and come cascading from her eyes. Dark eyes held anticipation of their own.
"Yes, Kakashi-sensei," She replied, head inching closer to her sensei's, as her mind had protests of reasons why she shouldn't be doing this, like; this is her eternally late, porn reading, teacher. They also have something called an age difference. But all of that didn't seem to matter.
There had been times in the past, where she stopped herself from doing anything too friendly with her teacher and was freaked out by it. Afterwards, she felt bad for turning him down.
This time, she couldn't turn him down. Not now. Not when he was looking for the one person who cared.
The woman couldn't handle it any more; she wanted to help him, to be with him, to belong to him.
Before either of them could have the opportunity to speak again, lips touched. Eyes widened. The hug tightened, as if she didn't want to let him go. A whirlwind of confusion faced through the jounin's brain.
Thoughts clashed, and he pondered on Sakura's motives, whether she was doing this out of friendship or something else. He soon learned that friendship would be ruled out when she pulled back and put her hands on either side of his face, lightly grasping the mask.
"May I?" She asked.
"We shouldn't be doing this..."
"It's something I want to do." She told him. "I want to see you smile again. All my life I've had to sit back there, watching, unable to help you. Watching everything go by and doing nothing. Well, now I can do something about it. You're more then a teacher to me now. "
"What are you trying to say?"
"I love you, Kakashi…I don't care if you're my teacher or you read those dirty books. I don't care what other people will think anymore." She told him, flattening her hands on the side of his face, caressing it gently in her hands. "All I really want…Is for you to accept me."
"I don't love Sasuke anymore. I'm tired of being hurt by people. I realize now that I was just pouring my feeling out to someone who would never love me. I'm not a little girl anymore, and I realize that I was foolish. I made a lot of mistakes back then, but now I'm turning it around and making things right."
There was a silence between them. A moment of understanding. A moment of contemplation.
The older ninja leaned his head in and pulled his mask down, when he got close to her lips he said, "I see your pain." Lips brushed against lips. "I will accept your help."
Sakura blushed, as she could feel his lips against hers. "Does this mean…?"
"I love you, Sakura."
The pink haired girl leaned her head downward and kissed her new love. He returned the kiss and wrapped an arm around her, feeling a new found warmth take over him.
They were no longer teacher and student.
They were lovers.
A/N: There's my little piece of KakaSaku. I had this in mind for a while; I just needed to write it down. Please review! If you want more KakaSaku, check out Lessons in Shinobi Love, also by me.


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- ILimestone CollegeGaffney, Scary12.Jan 2016
- Employee
Company culture
There is no fairness. Staff are constantly threatened with losing their jobs and discrimination is rampant.
Support from Management
Changes in leadership have destroyed an otherwise great and productive workplace.
Teamwork is not encouraged.
Level of Autonomy
The ones who perform well are overloaded and the freeloaders just freeload.
Communication consists of threats and insults.


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Movie Minis for the week of May 17-23
Capsule reviews and synopses of films playing in local cinemas this week (films rated on a scale of 0-4 stars):
"The Avengers"
*** 1/2
After a series of summer blockbusters that individually introduced Iron Man, The Incredible Hulk, Thor and Captain America, all these characters come together alongside several other friends and foes. And with director and co-writer Joss Whedon, they couldn't be in better hands. He's pulled off the tricky feat of juggling a large ensemble cast and giving everyone a chance to shine, of balancing splashy set pieces with substantive ideology. The result is a film that simultaneously should please purists as well as those who aren't necessarily comic-book aficionados. PG-13. 143 min. (Christy Lemire, Associated Press)
"The Best Exotic Marigold Hotel"
In theory, seeing Judi Dench, Maggie Smith, Tom Wilkinson and Bill Nighy share the screen should be a delight. In reality, this seriocomic romp with a creaky script merely has its moments, but more often feels heavy-handed, sappy and overlong. Dench does some of the loveliest work as Evelyn, recently widowed after 40 years of marriage and struggling to establish an identity on her own. She's one of several elderly Brits who travel to a resort in Jaipur, India, that advertises itself as an elegant destination for retirees, but is in reality falling apart. PG-13. 122 min. (Christy Lemire, Associated Press)
"The Cabin in the Woods"
*** 1/2
Geek god Joss Whedon produced and co-wrote the script with director Drew Goddard in this horror spoof that walks a very difficult line and manages to find the right tone pretty much the entire time. "Cabin" pays tribute to the kinds of frights horror fans know and love while managing to provide surprises and twists over and over in a story about five friends who go away for the weekend to a remote cabin by a lake. R. 95 min. (Christy Lemire, Associated Press)
This fourth documentary from the Disneynature label, like last year's "African Cats," talks down and sugarcoats to coddle the tyke audience, a shame given the rarity of the intimate portrait provided of chimp life in rarely visited remote regions. Capturing the chimps on film isn't easy, so filmmakers Alastair Fothergill and Mark Linfield deserve high marks for their efforts, but the cartoonish names and story scripted around young chimp "Oscar's" real-life struggle to survive will appeal only to small children. G. 78 min. (The Hollywood Reporter).
"Dark Shadows"
* 1/2
Tim Burton and Johnny Depp are snuggled warmly in their comfort zone in this chilly horror-comedy, their eighth collaboration as director and star, respectively, and their weakest by far. Based on the gothic 1970s TV series, Depp plays the long-undead Barnabas Collins, a vampire who's been buried alive for nearly two centuries and suddenly finds himself back in his insular Maine hometown in 1972. The film is too languid, and bogged down with an obsessive eye for costumes and period detail rather than offering anything resembling an engaging story. PG-13. 116 min. (Christy Lemire, Associated Press)
"Darling Companion"
* 1/2
Lawrence Kasdan's shaggy dog of a film finds Beth (Diane Keaton) and her daughter, Grace (Elisabeth Moss), adopting a stray they find on the road and name Freeway. Grace falls for and marries the dog's veterinarian (Jay Ali); but when Freeway disappears, it ignites long-simmering tensions in Beth's marriage to Sam (Kevin Kline). It's a slight story with a talented cast begging for a little wit and a few jokes. PG-13. 103 min. (Jake Coyle, Associated Press)
"Dr. Seuss' The Lorax"
From the makers of "Despicable Me," the latest "Dr. Seuss" film adaptation is better than most. The environmental parable is too busy for its own good and a little overstuffed with story. But the design is witty and imaginative, and the small grace notes are enough to keep an open-minded adult giggling. PG. 94 min. (Christy Lemire, Associated Press)
"The Five-Year Engagement"
Another Judd Apatow film that stays too long at the party, this rom-com starring likable actors Emily Blunt and Jason Segel is so scattered and slow-paced, it really feels like it lasts five years. R. 124 min. (Christy Lemire, Associated Press)
"Girl in Progress"
* 1/2 (out of 4)
The strong, sexy presence of Eva Mendes and the girlish perkiness of Cierra Ramirez can go only so far to make this forced, made-for-TV-style mother-daughter dramedy tolerable. It's a coming-of-age story that tries too hard with cliched characters, cutesy dialogue and lessons learned the hard way. Mendes' Grace is the child in the equation, having given birth when she was just 17 and hopping from man to man and town to town while her hyper-responsible daughter keeps the home fires burning. PG-13. 84 min. (Christy Lemire, Associated Press)
"The Hunger Games"
Fans should be satisfied with director Gary Ross' adaptation of the first of Suzanne Collins' best-selling trio of novels about Katniss Everdeen, the independent, 16-year-old heroine fighting for survival in a futuristic, fascist society. Some subplots are truncated and the violence of the games (where 24 teens are selected each year to compete in a televised battle to the death) is softened, but it feels both epic and intimate at once. PG-13. 142 min. (Christy Lemire, Associated Press)
"A Little Bit of Heaven"
Kate Hudson plays a cancer patient who falls in love with her doctor (Gael Garcia Bernal). The film tries to be both a medical drama and an ode to romance. PG-13. 106 min. (McClatchy Newspapers)
"The Lucky One"
* 1/2
The latest film adaptation of a Nicholas Sparks novel is predictable, schmaltzy, sappy and smothered with voiceover that explains the melodrama's unsubtle themes of destiny. Zac Efron plays a Marine who's just returned from his third tour in Iraq with an item he believes saved his life: a photograph he found in the war zone of a beautiful woman (Taylor Schilling). He tracks her down in an idyllic Louisiana town, doesn't tell her why he's come, and they fall in love. PG-13. 101 min. (Christy Lemire, Associated Press)
"Mirror Mirror"
Julia Roberts chews up the gorgeous scenery a the villainous evil Queen in Tarsem Sigh's Snow White adaptation, which is beautiful to watch, but suffers from a dull, plodding script. PG. 106 min. (Christy Lemire, Associated Press)
"The Pirates! Band of Misfits"
Aardman Entertainment ("Wallace & Gromit") are back with this British stop-motion animation family comedy about a frustrated Pirate Captain (voiced by Hugh Grant) who is trying hard to overcome years of losses for the title of "Pirate of the Year." The voice cast is a who's who of British film royalty, but the talky film's laughs aren't as plentiful as they should be. PG. 88 min. (McClatchy News Service)
"The Raven"
* 1/2
Edgar Allan Poe is probably clawing at the inside of his coffin, desperate to get at the people who used and abused his diabolical tales as the basis for this pile of cinematic bird poo. A whiny, over-the-top John Cusack stars as the macabre author on the trail of a serial killer who's re-creating in real life the grisly murders from Poe's stories. The movie reinforces how fiendishly clever Poe's ideas were, but the filmmakers make poor use of their source material, wringing a few moments of gore from them while adding no suspense or originality of their own. R. 110 min. (David Germain, Associated Press)
* 1/2
The thin story has Statham as a mystery man with deadly skills who becomes the unlikely protector of a Chinese math prodigy (newcomer Catherine Chan) on the run from Chinese and Russian mobsters. R. 95 min. (David Germain, Associated Press)
"Salmon Fishing in the Yemen"
This British rom-com is heavy on the whimsy, about a fisheries department bureaucrat (Ewan McGregor) and a sparky London marketing whiz (Emily Blunt) thrown together to work on the cockamamie concept of stocking a Yemeni waterway with upstream-swimming fishies from the U.K. PG-13. 107 min. (Steven Rea, Philadelphia Inquirer)
"Sound of My Voice"
*** 1/2
Brit Marling, as director, co-writer and star, follows up on the promise of last summer's "Another Earth," with this mesmerizing sci-fi thriller about a woman who may be a time-traveler from another world or a charismatic con artist heading up a San Fernando Valley cult. The film never reveals her truth. You could argue your interpretation of her actions in a number of ways. R. 84 min. (Christy Lemire, Associated Press)
"Think Like a Man"
Steve Harvey's best-selling dating advice book, "Act Like a Lady, Think Like a Man," serves as the launching pad for four intertwined stories in which various types couple up and try to make a go of it. With the book treated like an indispensable bible by the female characters, the film becomes a shameless, overlong infomercial, but the likable cast (including Michael Ealy, Taraji P. Henson, Romany Malco, Meagan Good) makes the film enjoyable. PG-13. 122 min. (Christy Lemire, Associated Press)
"Titanic" in 3-D
If any film should be redone in 3-D, it's "Titanic." And if any filmmaker should be the one doing the redoing, it's James Cameron. He's been a pioneer in advancing this cinematic technology for years. And so ironically, for a film that hasn't got an ounce of understatement in its three-hour-plus running time, "Titanic" in 3-D is really rather subtle and finely tuned, with no gimmicks. It's gorgeous: crisp and tactile, warm and inviting, until all hell breaks loose in this spectacular, Oscar-winning retelling of the great ship's sinking 100 years ago. PG-13. 195 min. (Christy Lemire, Associated Press)
"The Three Stooges"
A little nyuk-nyuk-nyuk goes a long way in Peter and Bobby Farrelly's feature-length tribute to the classic slapstick comedy trio. "Stooges" is sweeter than you might expect, and it's certainly more tolerable than their last movie, the crass "Hall Pass." But it's hard to imagine who the film is for today, beyond hardcore fans of the original shorts and 10-year-old boys who double over giggling at the sight of grown men doubling over in pain. PG. 91 min. (Christy Lemire, Associated Press)
"21 Jump Street"
** 1/2
The TV show that made Johnny Depp a star is little more than a jumping-off point for this rowdy, raunchy big-screen update that aims for laughs over action and delivers them intermittently. Jonah Hill and Channing Tatum are surprisingly amusing together as newbie cops sent undercover as high school kids to root out a drug ring. It doesn't work all the time, or even most of the time, but it does work enough of the time to make this more enjoyable than most of Hollywood's unimaginative remakes and updates. R. 109 min. (David Germain, Associated Press)


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Georgian Tray in Old Sheffield Plate
c. 1820 Sheffield
Offered by waxantiques
SoldRequest Information Call Dealer Favourite Item
A good antique tray with plain centre and shell and gadroon border. In fine original condition and still retains the silver shield in the centre. Width (across the handles) 63 cms. Width 39 cms. Circa 1820.
Please note that this item is not new and will show moderate signs of wear commensurate with age. Reflections in the photograph may detract from the true representation of this item.
Stock Code3464
MediumOld Sheffield Plate
49 Camden Passage
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Celebs react as Trump revokes trangender students' bathroom protections
Washington D.C. [USA], Feb. 23 (ANI): As U.S. President Donald Trump's government revoked landmark guidance issued to public schools, in defense of transgender student rights, numerous celebs took to social media to speak out about their opposition.
In the wake of the announcement, which would permanently scrap transgender student protections in schools, talk show host Ellen DeGeneres tweeted, "This isn't about politics. It's about human rights, and it's not okay."
Ellen DeGeneres Show no more in trouble as 'i' can be pronounced in several ways
Washington D.C. [USA], Feb 17. : A plea of a Georgia woman, who sued the 'Ellen DeGeneres Show' producers in June, for wrong pronunciation of real estate agent Titi Pierce's name, has been ruled out.
According to a TMZ.com report, the case was ruled out as according to the judge, there was nothing untoward about DeGeneres poking fun at realtor Titi Pierce's name, which she pronounced as "Titty," reports TMZ.com.
Ellen DeGeneres congratulates George, Amal Clooney in a hilarious way
New Delhi [India], Feb. 10 : As Hollywood celebrities rush in with their congratulatory messages for the soon to be parents George Clooney and Amal Clooney, Ellen DeGeneres went ahead a step to make her wishes even more amusing.
The comedian and talk show host took Instagram and posted a photoshopped picture of George's face and replaced that with Bey's insanely famous pregnancy announcement picture.
She captioned the picture, "It's twins for George and Amal! I thought I noticed a baby bump. Congrats, you two!"
Ellen uses 'Finding Dory' to slam Trump's Immigration ban
Washington D.C. [USA], Feb. 1 : Ellen DeGeneres recently voiced out her opinion on the refugee ban imposed by President Donald Trump by talking about 'Finding Dory', the animated comedy-drama which was reportedly screened in the White House on Sunday.
During the episode of 'The Ellen DeGeneres Show', the host said although she doesn't "get political," she would like to address recent events through her animated film.
Ellen pays heartfelt tribute to President Barack Obama
Washington D.C. [USA], Jan. 20 : To commemorate President Barack Obama's final day in office, Ellen DeGeneres spent a few minutes of the latest episode of her talk show, saying goodbye to him and First Lady Michelle Obama.
"I want to personally thank [Barack] for changing my life," DeGeneres said. "I am a legally married woman because of him, and so is my wife [Portia de Rossi]."
"His courage and compassion created equality for everyone," she continued. "He moved us forward and made more happen in the past eight years than I ever dreamed possible. I love him. I love Michelle."
Justin Bieber single but not ready to mingle
Washington D.C. [USA], Dec. 6 : Justin Bieber, who has been romantically linked to several women in the past, now he tells Ellen DeGeneres that he is single though he is "not really looking" for anyone.
The 22-year-old singer recently appeared on ' The Ellen DeGeneres Show' where he revealed that he was not dating anyone at the moment and not really dying to enter a relationship, reports E! Online.
"I'm not really looking either," he told the daytime talk show host.
Robert De Niro comforts Ellen DeGeneres as she tears up receiving 'Presidential Medal Of Freedom'
London [UK], Nov. 23 : Looks like Robert De Niro just lent an emotional hand to Ellen DeGeneres, who could not stop tears from welling up as President Barack Obama presented her with the ' Presidential Medal Of Freedom' at the White House recently.
The 58-year-old comedienne was still crying as she returned to her seat next to fellow recipient Robert De Niro and the Oscar-winning actor kindly gave her a comforting hug, reports the Daily Mail.
It's "always gonna be Justin Bieber" for Serena Williams
Washington D.C. [USA], Nov. 19 : Tennis champion Serena Williams recently had a hard time choosing men listed by the host on 'The Ellen DeGeneres Show'.
During a game of 'Who'd You Rather?', the 35-year-old tennis champion burst out laughing when asked to choose between few Hollywood actors and Justin Bieber, reports E! Online.
"I am definitely going with Justin Bieber!" she gushed, pumping a fist in the air.
"Justin Bieber. You know what, it's always gonna be Justin Bieber," she affirmed as the pictures went on comparing the 22-year-old singer with Prince Harry and Bradley Cooper.
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MOVIE SYNOPSIS [ General Audiences ] Having as main character to Kate Bergeron, this film directed by Steve Goodman was premiered in theaters in 2009. The film "Girl U Want" had an original production of USA. You can watch Girl U Want online on TV cable or theaters with original audio in English at different dates. This film premiered in theaters in 2009.
Rating: 5 by 6 users./
Runtime: 83 minutes
Kate Bergeron, John Lange, Michael Larimer, Beata Luberda, Sophia Murillo, Melissa Seneczko and James Sorrels.
83-minute film (full movie) directed by Steve Goodman.
The original audio of Girl U Want has dialogues in Dolby Digital, it was produced in USA.
It premiered in cinemas or television in 2009.
Screenplay written by Steve Goodman.
Mike Stoklasa.
Steve Goodman.
This film was produced and / or financed by Sureshot Productions.
Composed by Brick Briscoe.
Without commercial breaks, the full movie Girl U Want has a duration of 83 minutes; the official trailer can be watched in streaming on the Internet. You can watch this full movie free in EnglishDolby Digital in movie TV channels, renting the DVD or with VoD services (Video On Demand player, Hulu) and PPV (Pay Per View, Netflix).
See the page of this full movie, Girl U Want in FULLTV Movies.


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That's the way to do it.
For Scott – captain fantastic – Parker, a man in motion with a pair of metaphorical wings that he doesn't need as others in the team can manage the aerial stuff.
Fulham dominated the first half to the extent that the second was under control, if frightening. Symons' continuing reliance on an attacking three of Ruiz McCormack and Rodallega meant that Charlton were always nervous, and with Parker and Christensen patrolling and controlling behind Fulham were able to dominate the ball and territory.
The goals were terrific: Parker's early strike coming after he won the ball, surged into the area and converted a cross that was behind him in off the bar. Rodallega's first was a study in anticipation, calmness and technique (from him and McCormack) and the third was worthy of far more celebrated names.
The whole thing clicked perfectly. It's a fine reflection on the manager that Fulham continue to thrive and surge up the table. Full reflection later.


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Three Locations.
Our main shop and office is conveniently located about 100 metres from the base of the Kitanomine Gondola in the Furano Ski resort. See map below, top left. We also have agents in Niseko and Asahi Dake.
At Niseko, we partner with resort rental specialist, Harrosnowsports. Harro's is located in Niseko Hirafu village, at the Gondola Chalets reception area. (Map below top right).
At Asahi Dake we work with Lodge Shirakabaso (YHA) based about 5 minutes from the Asahi Dake gondola. (Map below bottom right.).
Delivery and Booking. Please ensure you have given us three days notice if you require equipment to be picked up at our agent's in Niseko and Asahi Dake. We can also deliver to your hotel or Inn. Be aware though, that you must adjust your own bindings.
We cannot deliver boots due to sizing constraints.
Location Maps
- Bus From Chitose or Asahikawa Airports. Best access from Chitose (Sapporo) or Asahikawa Airports is via the Hokkaido Resort Liner bus.
- Train from Asahikawa or Chitose (Sapporo) Airport. Furano is about 1 hour by train from Asahikawa station. From Furano Station you will need a taxi to get to the resort. From Chitose you need to change trains at Takikawa. Check JR Hokkaido English website for details, timetables and general information.
- Taxi or Charter from Asahikawa or Chitose. We recommend this be arranged via our partners, Alpine Travel in Furano. They own and run both taxi and mini bus charter vehicles.
- Accommodation Bookings. Please contact Alpine Travel for all your accommodation needs in Furano and central Hokkaido.


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By Joe Haggerty
WILMINGTON, Mass. Bruins general manager Peter Chiarelli has pinpointed needs on his hockey club he hopes to address before the NHL trade deadline comes to pass on Feb. 28.
But a couple of things are making things difficult for Chiarelli with slightly more than three weeks leading up to that deadline. First is the fact that one of the needs identified by the hockey club manager is that of a top-four defenseman able to relieve some pressure on a 22-year-old youngster like Steve Kampfer thats playing upwards of 20 minutes a night with plenty of pressure on his shoulders.
Not to mention getting some Andrew Ference insurance. Ference has been outstanding this season while playing solid, reliable, spirited hockey from his defenseman position and posting 9 points and a plus-19 in 49 games.
The problem: Ference has already played 49 games this season in a relatively healthy year, but hasnt played more than 59 games in any of the last three seasons while battling through groin and hernia issues among other assorted aches and pains.
An NHL general manager cant simply expect that a 22-year-old rookie is going to sail through his first stretch run and playoff experience without a few moguls on the mountain, and shouldnt expect Ference to make it through the next 30 games and playoffs without something cropping up health-wise.
That means the Bruins need to add another defenseman to the mix moving forward, and Chiarelli said as much while chatting with the media following practice at Ristuccia Arena on Friday afternoon.
Id like to try and get a defenseman that could help our group, said Chiarelli. I think our defense has played very well, but were trying to ease some of the minutes off of our players.
Theres clear and obvious Bruins interest in defensemen like Sergei Gonchar and Tomas Kaberle given their skill sets as puck-moving defensemen and their availability while playing on God-awful NHL teams. Carolina Hurricanes defenseman Joni Pitkanen is another player that would fit in nicely with the Bs should be exposed to the trade market this month.
Both all of those players come with their own issues, however. Kaberle hasnt played a relevant NHL game in years, and some believe that the puck-moving blueliner is content to the point of dulling his competitive edge. Gonchar is a 35-year-old defenseman with two years at big money left on his contract, and any club taking him on is assuming all of the risk that goes along with it.
Theres a good chance Pitkanen wont ever make it to market as the Hurricanes catch up to the Thrashers in the Eastern Conference, and potentially push themselves into the playoff conversation.
But Chiarelli said that he expected any deal for a defensemen to be consummated with a Western Conference team, which really is at odds with the whispers that the Bruins were highly interested in Senators blueliner Chris Phillips.
Chiarelli called the market tight at this point in the month of February as so many Western Conference teams are still in striking distance of a playoff spot with 30 games or so remaining in the season and only four points separates the fifth place through 12th place teams out West.
That means there arent many sellers aside from the Edmonton Oilers, the Columbus Blue Jackets and perhaps the Blues now that injuries have slashes their season into ribbons.
Were not going to replace Savard because that guy is not available, but you can replace bits and pieces of it while things fall on the shoulders of some of our other players, said Chiarelli. Right now things are very, very tight. You hear that from me every year a month before the deadline and its even truer now.
The standings are very tight. You look in the West and things are tight, and usually if youre going to make a move itll be in the Westusually. I think teams 4-12 is like five points separating them. So a lot of the players we like arent available because their teams are still in it.
The other problem: the Bruins must come to a conclusion about Marc Savard and his concussion problems after suffering the fourth serious brain injury of his NHL career two weeks ago. Placing Savard on LTIR would certainly open up some flexibility for the Bruins, and dealing a spare defensemen with value around the league like Mark Stuart who several teams including the Atlanta Thrashers have expressed interest in -- would further open up the options for Chiarelli and Co. to make some roster improvements.
Chiarelli would only say that the team needs to be creative when thinking about finding a solution for filling the absence of Savard due to injury. The Bs GM admitted that there isnt anybody on the trade market thats likely to give the Bruins exactly what theyre missing in the form of No. 91 both on the power play and five-on-five but they never really saw the full 100 percent healthy Savard at any point this season anyway.
It certainly gives us more flexibility, so it allows us to do some other things, said Chiarelli. Were just not going to be able to replace Savard because that skill just isnt going to be available in trade. Were going to have to get creative.
Chiarelli would love to go shopping with the Bruins for a player list thats been pared down, tabulated and approved, but it appears hell be waiting things out along with the rest of the NHL as teams decide their buyer or seller status. The good news: the Bruins are tops in goals against average, among the best offensive teams in the East and dont come from anywhere the kind of desperate straits they did last season.
Chiarelli captured Mark Recchi two years ago and Dennis Seidenberg last season at the trade deadline, and it doesnt much appear the GM will hesitate to pull the trigger again over the next few weeks.
Joe Haggerty can be reached at firstname.lastname@example.com. Follow Joe on Twitter at http:twitter.comHackswithHaggs


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Paul H. Schlesinger
Associate professor of cell biology and physiology, Washington University School of Medicine, St. Louis, Mo.
Primary Contributions (1)
in biology, a mechanism that allows cells to self-destruct when stimulated by the appropriate trigger. Apoptosis can be triggered by mild cellular injury and by various factors internal or external to the cell; the damaged cells are then disposed of in an orderly fashion. As a morphologically distinct form of programmed cell death, apoptosis is different from the other major process of cell death known as necrosis. Apoptosis involves condensation of the nucleus and cytoplasm, followed by cellular partitioning into well-defined fragments for disposal. In multicellular organisms, cell number normally results from the rate of cell production minus the rate of apoptosis. Discovery of programmed cell death In the early 1840s, a biological use for the mechanism of planned apoptosis became apparent when scientists realized that the development from fertilized egg to adult is not a linear process. In many instances, initial structures, such as the tadpole's tail, are superseded by entirely...READ MORE


text: Donkey Kong Country 3: Dixie Kong's Double Trouble!, known in Japan as Super Donkey Kong 3: The Mysterious Kremis Island, commonly abbreviated to DKC3, is a 1996 platforming video game developed by Rare and published by Nintendo for the Super Nintendo Entertainment System. The game was the final installment in the Donkey Kong Country series. Donkey Kong Country 3 is a platform game where players control Dixie Kong and her cousin Kiddy Kong through 48 levels. Many of the gameplay elements from previous games in the series see a return in this game, such as barrels, bonus levels which reward the player with special "bonus coins," DK coins, animal helpers and co-operative play. Both of the two playable Kongs have unique abilities, such as Dixie's ability to slow her descent by spinning her pony-tail, and Kiddy's ability to bounce across open water. The Kongs can also throw each other around levels to break cracked floors, hit switches or reach secret areas. More info: Wikipedia


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Brand New Books for Black History
The collection at the Idaho Black History Museum is getting a bit larger thanks to a donation from Sen. Mike Crapo.
Crapo is officially turning over the multi-volume collection, Black Americans in Congress 1870-2007, to the museum on Wednesday, Feb. 18, as part of events marking Black History Month.
The hardcover books were prepared with help from a directive from the U.S. House of Representatives and a copy is kept in the Library of Congress. The Boise-based museum, the only one of its kind in the Gem State, is still figuring out how to best use the collection, but officials said they would like to make it available for educators to use in the classroom.
Ready, set Art
Make your plans now to check out the perennial favorite, We Art Women, an event celebrating female artists while raising money for the Women's and Children's Alliance.
The event takes over the Esther Simplot Center for the Performing Arts on Thursday, Feb. 26, with live music, live and silent auctions, art sales and food. Local artists Sherri Carter, Jany Seda, Marcia Marne and Julie Clemons will be on hand for the quick draw—kind of a friendlier, art version of the old Western shoot-out. Artists create original works on the spot within a set time period. The works are then auctioned off, sometimes while still wet.
Twenty percent of the proceeds from the event will go to support the local nonprofit, which provides needed services to women and children escaping domestic violence. A $25 donation is requested at the door.
For more information, check out the Feb. 25 issue of Boise Weekly.
Idols Past
Where do all those all those American Idols and American Idol wannabes go when their album sales get shaky? They join a touring Broadway musical, of course.
Ain't Misbehavin' will take over the Morrison Center for three shows March 24-26 and stars former Idol winner Ruben "The Velvet Teddy Bear" Studdard. He will be joined on stage by former Idol contestants Frenchie Davis and Trenyce Cobbins.
It's the 30th anniversary for the musical revue, which won a Tony award for Nell Carter, who starred in the original production.
Tickets go on sale on Friday, Feb. 20, and cost between $28 and $48 before fees. Performances will begin at 7:30 p.m. each night. Tickets are available online at idahotickets.com or by phone at 208-426-1110.
Bargain Culture
Need a bit of culture without dropping much cash? Boise Philharmonic will open its dress rehearsal for its upcoming concert, An Evening in Vienna, on Saturday, Feb. 21, 10 a.m., at the Morrison Center.
The program features compositions from Arnold Schoenberg, Mozart and Schubert and will be led by guest conductor Karen Lynn Deal and violinist Ju-Young Baek.
Sure, it's a rehearsal, and you may end up hearing portions of the program repeatedly, but it's hard to beat the price: $7 for students and seniors or $12 for adults. Tickets are available at the door that morning.
For those who want the full-concert experience, the orchestra will perform An Evening in Vienna Friday, Feb. 20, 8 p.m., and Saturday, Feb. 21, 8:15 p.m. Tickets for the main performances cost between $20 and $61.
For more information or to buy tickets, visit boisephilharmonic.org.
Now That's Recycling
Is dry macaroni glued to construction paper considered recycled art? Truly creative kids with a green outlook will be showing off their creations at the opening reception for the Kids Recycled Art Contest Monday, Feb. 23, 6-8 p.m., at Art and Soul Gallery, 480 Thurman Mill St. in Garden City.
Students in kindergarten through 12th grade entered their best two- and three-dimensional art, all made out of non-toxic, found and recycled materials. Awards in various age categories will be announced at 7 p.m. Check out the details at greenfoundations.com.


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1 gallon instrument dual enzymatic concentrate cleaner. Free Rinsing, does not leave a residue. Breaks down three times more bio burden than the market leaders within five minutes. Bacteriostatic, Prevents the additional growth of harmful bacteria while in solution. Low foaming for use in ultrasonic cleaners, evacuation systems, reprocessing units and washer / sterilizers. Contains a special rust inhibitor that prevents corrosion on metal instruments. Neutral pH making it safe to use for almost any medical and dental device. Economical, super-concentrated formula 1 oz (30mL) makes 1 gal (3.8L) of solution. The soaking container must be covered when not in use.
Sultan Medical 21380 420363 1 Gallon ZymeX Jug Instrument Dual Enzymatic Cleaner Concentrate 42281704 Use on Instruments and Medical Equipment


text:
Join our General English classes any Monday.
Do you really want to improve confidence and skills when speaking English? If so, then this is the course for you!
This course is designed for those students, who really want to concentrate on obtaining fluency in English.
This English course is for people who wish to improve their general level of English.
This English course is for people who wish to improve their general level of English but who also want an opportunity to do a little extra work in the afternoon to practise and consolidate what they have learnt in the morning session.
The Vacation English course consists of 20 lessons each week and is the least intensive option offered at Kaplan.
This is a part-time programme that runs all year.
This course is a full-time programme that runs all year.
English World courses are designed to have an impact on your present and future life in an international environment.
English World courses are suitable for students who want to improve their all round skills and performance in English.
Get the best of both, by having one-to-one learning and group classes in a Combination course.
One-to-one tuition is available all year round with one of our experienced teachers.
inlingua Edinburgh has a string reputation for preparing students to sit Academic English Exams in our city centre language school.
One-to-one tuition is available all year round with one of our experience teachers.
*Prices are subject to change without notice due to exchange rates.


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text: Photo by Chip Somodevilla/Getty Images [ Ann Coulter Visits Sean Hannity On Fox News, Talks Boston [VIDEO] By James G April 23, 2013 Ann Coulter recently sat in on Sean Hannity's Fox News Show. Read More Category: Videos Tags: 940, ann coulter, fox news, kixz, sean hannity, video Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


text:
My workplace.. by Boss429Watch
©2008-2017 Boss429
Love this drawing board, can't believe I drew all these years without one!, folds down nicely too so when I'm not drawing it can be put out of the way.
This was a few years ago now and I must admit it would look a bit more cluttered and messy looking if I was in the middle of drawing!
What kind of drawing board is that? Where did you get it?
Is that Eleanore on the Table Left ...nice Geeks bro
Isn't the monitor too far from the keyboard? I don't like the idea that they are facing different directions.
It has a Web 2.0 feeling to it, haha. Very nice.


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Pearson - Hydraulic Chute
Vertical sides allow cattle to move into the chute easily and stand in a relaxed, natural position. Automatically adjusts to any size animal as chute is squeezed. No climbing sides or excessive slipping. Neck panels swing out for neck vaccinations or branding. Additional access doors/panels provide easy access for branding, clipping, foot work, milking, and cesareans. Reversible head sweep. Heavy, rugged construction. Powder coated for durability. Standard Rancher Hydraulic Chute includes: Brisket Bar, Calf Wings, Top-mounted Electric Power Unit - 220V 1Ph or 380V 3Ph (Remote Gasoline Power Unit Available), Hydraulic Head Sweep, Hydraulic Head Gate, Hydraulic Tail Gate, Controls Mounted to Top Frame at Shoulder Level (Drop Arm Controls Available), Neck Doors, and Double Side Exits.
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"Outrageously poor care which puts people in..."
About: Hillingdon Hospital Hillingdon Hospital Uxbridge UB8 3NN
Posted via NHS Choices
What I liked
What could be improved
Had my first child there in 2011 and now pregnant with second baby.The building is a dirty dump,staff are rude and careless. I also had an open appendectomy there in 2011 and had to go without pain relief for hours after the operation,yet I was expected to get out of the bed within 2 hours of the operation by two nurses screaming at me to go to the toilet if I need to and they aren't going to lift me or help me, yet and all was given is 2 paracetamol tablets. In an effort of pushing myself up from the bed, the cannula broke in my vein and the fluids went into the tissue causing my hand to swell up and bruise.I was in horrible pain and I was begging for proper pain relief but haven't been given anything until next morning when I was about to self-discharge.As of the birth,I had a C-section and again I had to ask several times for pain relief and wait hours.I was left on the open ward after the operation and my family was sent home as the visiting time was over, I was forced to look after the baby alone despite the major operation I had and despite the insufficient pain relief (once the catheter was removed,so was the drip and I had some pills instead which didn't work but it was just ignored). I tried asking for help but the nurse was always busy and my baby was screaming in his dirty nappy and I have ended up doing everything myself.I also received no help with breastfeeding. It was not possible to have any rest because when my baby was sleeping and could have had some rest until the next feed, someone else's baby was screaming.
Anything else?
Additionally, the windows on any of the wards couldn't be open more than 5 cm due to security reasons, there was no air and the whole ward was boiling.By the end of the 3rd day after my C-section, I have requested to be discharged despite my still high blood pressure because I just couldn't take more.I suggest that anyone who can avoid this hospital, do so.With my recent pregnancy,I have transferred my care at 31 weeks to another hospital despite it's 20 miles away.
The average waiting time for antenatal appointments is 1 hour or more. I have hardly ever seen the same consultant. Also, I have not been diagnosed on time with a major condition because as per the midwife and the consultant, they can't afford to test women based on the risks listed in the NICE guidelines. In this particular case it means that instead of screening women with the BMI of above 30, they only screen women who have a BMI of 35 or above. Screening of women with BMI of 30 is too expensive even though this particular screening has the cost of 2 simple blood tests (checking blood sugar only) and 1 bottle of Lucozade. As a result of late diagnosis, my baby is bigger than should be and has increased risk of complications. I am wondering what other basics are they saving on which puts people at risk.
I have been impatient in the following wards in the last 2 years: Fleming, Marina, Katherine, Labour ward, Postnatal ward. The nursing care was the same bad standard everywhere, pain relief was not provided properly, if I ever happened to press the buzzer, I was given dirty look, most of the nurses were rude or simply too busy to care. I can count on one hand how many nice and helpful midwives and nurses I have met even if I add up all admissions I had.
Response from Hillingdon Hospital 2 years ago
Thank you so much for taking the time to give us feedback on our service. Please accept our apologies for the care you received during your time with us. I will be sharing your letter with the staff to reflect upon and learn from your feedback.
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Thesis topic proposal
Segmentation of 3D Structures in Volume Images Using Higher Order Active Contours
University of Szeged
computer sciences
PhD School in Computer Science
Thesis supervisor:
Zoltán Kató
Location of studies (in Hungarian): SZTE
Abbreviation of location of studies: SZTE
Description of the research topic:
When human observers are interpreting images, they are not only taking into account direct observations like color or intensity, but also a priori knowledge about the world. However, such a complex, interacting method is rarely used in image processing systems. Most of the algorithms are bottom-up: they try to extract some
useful information (basically a segmentation) solely from the observed image data and then the segmentation is interpreted. Obviously, image data alone cannot provide reliable information. Hence the use of higher level knowledge, in the form of shape priors, received more attention in the past few years. The dominating approach adopts a variational or level set framework where the segmentation criteria is summarized in an energy functional which takes its minimum at the desired segmentation of the input image. Previous work concentrated
on foreground - background segmentation with a data model relying on image gradient and with template-like shape priors where the actual contour is matched to a reference shape and high deviations were penalized. However, handling of more than one, possibly different objects in a scene remains a challenge as well as the use of more elaborated data models, especially in the area of volume image processing. Here we propose to extend
the idea of Higher Order Active Contours (HOAC) for 3D volume image segmentation. In a HOAC model basic geometrical constraints are modeled by quadratic energy functionals in a level set framework. The method has been successfully applied to road extraction from satellite images using a prior which favors network-like objects as well as to tree crown extraction using a "gas of circles" prior.
Specific aims of the proposed work
1. Studying the possible 3D generalizations of the HOAC model.
2. Stability analysis of the 3D model which constraints the possible parameter settings for a given 3D shape prior.
3. Development of efficient data likelihood models and their integration into the 3D HOAC framework.
4. The proposed solution will have applications to problems of interest in a wide range of areas, such as automatic segmentation of medical images, analysis of nanostructures in electron-microscopic images, or trajectory detection in temporal volume images (i.e. video sequences).
Collaboration: The proposed research is closely related to our collaboration with the ARIANA research group at INRIA, Sophia Antipolis, France.
Number of students who can be accepted: 1
Deadline for application: 2018-01-31
All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )


text:
OutBack Plus
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Protect your valuable Outlook data (email messages, contacts, tasks, email accounts, signatures, message rules, etc) with a simple to use backup and restore utility. OutBack Plus 4 will find all of the critical data for Outlook 98, 2000, 2002 (Outlook XP) and 2003, and save it to a compressed, password protected, backup file. The new Outlook 2003 Business Contact Manager DB is also included in the backup.Visit publisher site: OutBack Plus
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text:
It was a sad moment not only for John Bolton, but for America when he tendered his resignation this morning.He did a splendid and even outstanding job as UN Ambassador in a very dificult period of history.That Democrats did not see his value is par for the course.That Sen Chaffee blocked the approval of the nomination,so the whole Senate could vote up or down confirms the wisdom of the people of R.I. who did not re-elect him.
Even though the RNC and the White House placed much political capital and funding into his campaign,he did not reciprocate .He will not be missed in the Senate,and the Republican party is better with him on the outside.
I had the opportunity last nite to watch Newt Gingrich on PBS as he spoke in New England.By far ,in my opinion,he is the the most articulate of the potential candidates for President.His vision of America,15 anf 25 years hence ,reveals his intellectual strength, is well thought out,and deals with issues and not partisanship.
His analysis of the need for all citizens to speak English,and become part of the American tradition strikes a chord that is is basic an answer to the attempts by some to come to America in order to change her to their own religion and traditions. We are a melting pot and not multi-cultural and multi-lingual. society.
Newt,as a college professor,understands the needs for not only education,but of projecting the computer technology of our youth and parlaying it into real advancement.His words will be met by resistance from the educational unions and beaurocracy.
He speaks clearly about evil in the form of Iran. It is unlike the athiesim of the Soviet empire.This theologic movement, seeks to destroy the West including Israel.They mean what they say,and there is no room for dialogue with such a regime.When a woman is prepared to make her 6 month old child a suicide vehicle,as in the recent London plot,there is no rational way to deal with such an opponent-except defeat--ours or theirs.
He makes a plea for greater face to face real debates in campaigns in the style of Lincoln -Douglass,and not through 30 second bytes to a moderator.
Of course Newt is still a controversial figure,but I would hope that even Democrats would at least listen to his words.
Past president of the Orthodox Union. Former Exec. VP of the Religious Zionists of America.