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Find the Grinch (pictured above) and Grow Your Heart Three Sizes at participating IndieBound Naperville Businesses this Holiday Season Dec. 1 through Christmas Eve. Raffle Drawing Dec. 28, 2016!
Plan time to play. Grow your heart!
Pick up a button! Pick 12 locations!
Find the Grinch hiding out at participating IndieBound Naperville businesses this holiday season from Dec. 1 to Christmas Eve. Then at 1PM on Dec. 28, 2016, participate in the fun at Anderson's. And plan to "Grow Your Heart Three Sizes" throughout 2017!
A "bingo-style" sheet with a list of participating merchants, always growing with generous hearts, is now available at Anderson's Bookshop in downtown Naperville. Pick up instructions and the game sheet and be prepared for the kick-off day on Dec. 1, 2016, for a month of sharing the spirit of the season.
If you visit an IndieBound Naperville business that is not featured on the game sheet and you spot the Grinch in that location, ask the owner/manager to mark your "Find the Grinch in Naperville" sheet with his name and circle it. It will count!
For starters, here's a partial list of participants…
Anderson's Bookshop / 123 W Jefferson Ave.
Anderson's Toyshop / 111 W Jefferson Ave.
Annica Float Club / 4S100 N IL-59, Ste 6
Artistic Creations Salon / 22 W Jefferson Ave.
Ask Aunt V with Twisted Olive (Two in One!) / 232 S Washington St.
Cookie Dough Creations / 22 W Chicago Ave.
Couture Vision / 232 S Washington St #3
Dean's Clothing / 226 S. Main St.
DeEtta's Bakery / 428 W 5th Ave.
Dog Patch Pet & Feed / 1108 E. Ogden Ave.
Edie Boutique / 15 W. Jefferson Ave.
Eggs, Inc. / 220 S Washington St.
Everdine's Grilled Cheese Company, 24 W. Jefferson Ave.
Ellman's Music / 508 W. 5th Ave.
First Community Financial Bank / 24 W Gartner (Naperville Plaza)
Gelati / 24 W Jefferson Ave.
Gotskind's / 115 W Jefferson Ave.
Growing Place / 25W471 Plank Rd.
Heaven on Seven / 224 S. Main St.
It's a Bling Thing / 14 Jackson Ave.
Kreger's Brat & Sausage Haus / 605 N Ellsworth
Liam Brex / 222 S Main St.
Lou Malnati's / 131 W Jefferson Ave.
Naper Auto Works / 320 N Mill St.
Naperville Fine Art Center & Gallery / 508 N Center St.
Naper Nuts and Sweets / 10 W. Jefferson Ave.
Naperville Running Company / 34 W Jefferson Ave.
Naperville Running Company / 3416 S Route 59, Suite 116
Naperville Senior Center Adult Day Services, 1504 N Naper Ave.
Naperville Tennis Club / 1011 E Benton Ave.
Popcorn Palace / 30 W. Jefferson
positivelynaperville.com / www.positivelynaperville.com
Quigley's Irish Pub, 43 E. Jefferson Ave.
Russell Martin Carpet / 633 N. Washington near Fifth Avenue
Saraboo Creek, 107 W. Jefferson Ave.
S&R Monogramming Inc. / 28W600 Roosevelt Rd Winfield, IL 60190
Second Chance Retail Shops / 1512 N Naper Blvd.
The Irish Way Shop / 105 W Jefferson Ave.
Twisted Olive / 232 S Washington St.
Two Bostons / 103 W. Jefferson Ave.
Visit Merchants and find 12 Grinch Images
Visit 12 merchants where you see the bright red sign. Look for the image featured at the top of this post to be eligible for youthful Grinch prizes at the wrap-up party the last week of the year beginning at 1PM Wed., Dec. 28, at Anderson's Bookshop in downtown Naperville.
Collect 12 signatures or stamps from 12 different merchants and turn it into Anderson's for the raffle drawing. It's free to play for great prizes provided by many members of IndieBound Naperville.
It's free to play. Join the fun. Meet the Grinch. All ages welcome.
Thanks for discovering and supporting your Naperville independent business community whenever possible every other day of the year, too!
Look for IBN's red logo, a fine sign that distinguishes independents and their never-ending value. Thanks also for recognizing independents and local businesses in every community!
Catch the giving spirit!
Local independents have big hearts all year long and especially during the holidays. Here's a small sampling of their giving spirit…
For instance, the Growing Place helps with coat drives for Wayside Cross and Hesed House.
Cowart Chiropractic also collects coats for Wayside Cross.
Casey's Foods collects for Little Friends Giving Tree and contributes to important causes all year long.
First Community Financial Bank collects Toys for Tots and will feature the Little Friends Giving Tree.
Anderson's Bookshops hosts Jan's Book Angels.
Second Chance Resale Shops benefit Family Shelter Service all year.
Catch 35 is collecting gently-used warm coats, hats, gloves and mittens.
Meson Sabika is hosting its annual complimentary Thanksgiving Dinner for 2,500 people.
Naperville Running Co. assists DuPage PADS.
Naper Auto helps promote Naperville Responds for Our Veterans.
Blooming Color, known for its generous support of myriad local causes, now features a new online greeting card service for every holiday of the year.
Signature Cleaners helps Brides Against Breast Cancer.
Find Naperville Art League, Lakewood Asset Managament, ViaMedia, Full Armiur, Ellman's Music Center, S&R Monogramming and others collecting non-perishables for Loaves and Fishes Community Services.
Shop Locally First
And in the words of independent grocer Dan Casey, owner of Casey's Foods, "Support your local businesses and you'll always live in a nice community."
Take a moment to wonder this holiday season how shopping online with faraway companies benefits your local community.
Be sure to swing by Casey's Foods where bell ringers from the Salvation Army are stationed right out front. And inside, the Little Friends Giving Tree is an opportunity to learn about Little Friends and some of the needs of their clients during the holiday season.
Above/ In 2008, Positively Naperville, the city's independently-owned monthly publication, was among the founding members of IndieBound Naperville. PN has been promoting the group that meets monthly ever since. Today their message and membership to promote shopping locally continues to grow one business at a time.
Thanks for getting to know them all for their merchandise, services, community spirit and independence!
Note the "Cock Robin" Gingerbread Man, representing one of Naperville's early independent businesses, a whimsical painted sculpture from 2013 that attracted folks to downtown Naperville, just as the Fredenhagen ice cream enterprises did for 60 years. Today Cock Robin "One in a Million" t-shirts help promote another small business called Color Burst, owned and operated by Little Friends, Inc.


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For the day of May 1st, these are the Top 20 trends, which include Paranormal Plane Paintings, Comic Book Sculptures and Stunt Car Photography. The rankings are based on hundreds of thousands of views and 55 new trends today.
The top Trend Hunters today were: Meghan Young (13 trends), Alex Scott (12), Luisa Amanda Gomes (10), Vittoria Natarelli (3), Michael Hines (3), Tiana Reid (3), Trend Hunter Robot (3), Amanda Chang (2), Jonathan Minster (1), and allison love (1).
If you are looking for professional trend research, make sure to check out our 2010 Trend Reports and Trend Hunter Pro.
Unpublished -
Top 20 Trends of the Day (May 1)
More Stats +/-
Seductive Spy Bodysuits
Romantic Rocker Fashion
Comic Book Sculptures
Paranormal Plane Paintings
Monstrous Religious Art

subset: commoncrawl


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Dr. Catherine Hamlin and her team were recently in the states for the launch of Hamlin Fistula USA. Following is an exclusive interview with Dr. Hamlin and former CEO Mark Bennett, CEO of Addis Ababa Fistula Hospital.
By, Tiberah Tsehai: In AmharicEmiye is an endearing term for mother: what Dr. Catherine Hamlin represents to those she has touched in Ethiopia and around the four corners of the world.
Like a mother she cares for the poorest daughters of Ethiopia. They are shunned and often think of suicide as an escape from their harrowing state.
They suffer from obstetric fistula- one of the most devastating childbirth injuries- usually caused by several days of obstructed labor. Often, a stillborn is delivered and the woman is left with incontinence.
Although obstetric fistula has been eradicated in the United States for more than 100 years it is still prevalent in developing countries.
For over 50 years Catherine Hamlin has not only been repairing these women from their injuries but she has educated them, loved them, and sent them home in a new dress.


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build reputation and trust
You are your own brand. People who pick from pickmytemplates are looking for individuality, creativity and originality from you, the creative Sellers. By ensuring that you are submitting designs of top quality and standards will help you build your reputation. As your contribution/sale grows with us, it is always important to make sure that you submit quality Product Items. It will always be your responsibility to always check and double check your files before sending them to us. pickmytemplates have a set of Submission Guidelines to guide you through the selling requirements. When people buy from you, the process should be a hassle free, enjoyable and positive experience, indirectly you build trust.
originality and plagiarism
A designer takes pride in his work. One's great idea and design is defined by its originality and authenticity. For the sake of the creative community, pickmytemplates strongly says NO to plagiarism. Work hand in hand with us to create art with heart. For any suspected or reported plagiarized work, we will kindly reject your contribution.
submitting your product item
Quality. Quality. Quality. Always keep this in mind when you submit your Product Item for sale. See the checklist here. In order to sell with ease, you may want to know more on how it works here.
communication and responsiveness
Yes, you double checked. Triple checked. We are humans and human errors do happen. Do expect the Buyers to communicate with you quickly when such situation arises.
- stay in touch and respond to Buyer queries timely
- explain and communicate clearly
- be responsive and resolve issues diligently
- respect your Buyer who is frustrated and help them as much as you can
- be polite so your Buyers will be appreciative and return to buy from you again
respect and care
pickmytemplates cares for our community. Mutual respect among the Sellers, Buyers and our pickmytemplates team will help grow and nurture our community into a better place to pick what you love and create art with heart. Code of conduct is important, we prohibit bad behavior with negative exchanges, postings and publishings such as disparaging comments, threats, harassments and interferences to other Sellers or Buyers.
Sales license
All Product Items are covered by the Standard End User License and Buyers can purchase for personal and/or commercial uses and the end product is not for sale. Buyers can also choose to buy with the Extended End User License where it is for personal and/or commercial use and they can sell the end product.
file size limit
Up to 500 mb per file. Zip and compress your file size.
file upload
No multiple files are allowed.
how to refund buyers
The Seller is responsible to communicate and respond to the Buyer promptly at all times. Do expect the Buyers to communicate with you quickly when such situation arises. Do remember the Buyers are your customers so always do your best to serve them, make serious considerations and decide if a refund is to be made. pickmytemplates has a set of guidelines for offering refunds but we fully respect a Seller's decision if a refund is to be made. pickmytemplates only offers refund if the Product Item purchased by the Buyer is not working as per the Seller description, specification or the file is corrupted. It is the Buyer's responsibility to make sure they have the system, configuration and software set up done correctly. No refund is offered if Buyer has a change of mind due to sudden realization that the Product Item is incompatible to the software or hardware that they are using. Buyer has to be sure of their purchase and once it is downloaded, they take charge and responsibility for making the decision to purchase and for the Product Item they purchased. See checklist below
- Buyer pick what they love, and clarify doubts with Seller before they buy
- Buyer to double check and triple check that they have followed the setup instructions carefully
- Buyer to read through the Seller specification again to see if they have missed out or misinterpreted any information
- Buyer to contact our Seller to request for support, and work hand in hand to resolve any issues
- stay in touch and respond to Buyer queries timely
- explain and communicate clearly to clarify doubts, setup and download instructions et ecetera
- be responsive and resolve issues diligently, see if they have missed out or misinterpreted any information
- respect your Buyer who is frustrated and help them as much as you can
- be polite so your Buyers will be appreciative and return to buy from you again
- Seller contact us if refund is to be made, and we will do the rest
- Email to firstname.lastname@example.com to offer a refund


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The Streets of San Francisco is a Drama programme.
Seasons in Detail
The Streets of San Francisco
Excellent crime drama from the 1970s featuring karl malden as the wise Lieutenant Mike Stone who is partnered with the idealistic young Steve Keller played by Michael Douglas.
Together they solve homicide cases in san francisco, the scripts are involved and thoughtful and the performances of stars and guest stars are always compelling.
Genre: Drama
Running Time: 60 minutes (approx)
When is The Streets of San Francisco next on TV?
It's next showing on CBS Action Tomorrow, 4:25am and on CBS Action November 24th, 4:25am. See more...
Main Cast
Database last updated: Today at 13:31


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ETF assets in Europe hit a new record high last month, reaching $539bn (£411.56bn) in assets under management.
Data from ETFGI showed that inflows were not deterred by Brexit, with July seeing $9.4bn of inflows, marking the largest month for asset gathering in the year so far. July marked the 22nd month of consecutive net inflows.
"Investor confidence returned during July after the surprising result of June's Brexit vote. The S&P 500 was up 3.7 per cdent in July. Developed markets outside the US gained 5.1 per cent and emerging markets were up 4.8 per cent," says Deborah Fuhr, managing partner at ETFGI.
Fixed income ETFs saw the largest net inflows at $4bn, followed by commodity ETFs at $2.59bn, and equity ETFs at $2.2bn.
However, inflows have slowed on last year, with inflows year to date amounting to $31.73bn, below the $48.17bn gathered at this point in 2015.


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Contact Info / Websites
Recent Movie Reviews
Facebook Reality
Rated 5 / 5 stars
We had idea just like this :P
This was absolutely brilliant!! The animation was simple yet effective & the voices were really really good. The jokes were also brilliant :D
Infact, we had an idea just like this instead it was called "Real Life Facebook", looks like you beat us too it :p but you have executed it a lot better that we would've lol
Hyperboy: Episode 5
Rated 4.5 / 5 stars
Great to see the series back!!!
Me and my friend have been watching this series since episode 1 came out and were're sooo happy to see it back in such great form. The Animation was awesome and the voices were great. Yet it still felt like there was somthing lacking, like no real main situation. It was still awesome none the less tho. THANKS GENE!! :D
Magikarp vs Metapod
Rated 3.5 / 5 stars
This was pretty funny. Your animation has defiantly improved (more detailed and smoother) and also the humour was equally good.
Nice Work Sam ;-)
Yes, I am rather good :D
Thanks for the review!
Recent Game Reviews
Advanced Sprites Tutorial
Rated 5 / 5 stars
Yay, i know how to use sprites :D
ive always want to know the basic use of sprites and this is the best tutorial ive seen. Thanks
James The Pirate Zebra
Rated 5 / 5 stars
You're really getting use to this James Stuff! as usual, the best bit we feel is the intro animation :D
Nice Work Guys!!
Rated 3.5 / 5 stars
It pretty good....to say the least...
Not bad, nice idea about putting 2 classic games 2gether but I found kinda hard to control 2 at once, not impossible, but very hard.
Also there are so many ways you could have made it more innotive, but right now, its good enough
Recent Audio Reviews
Godly Encounter
Rated 4.5 / 5 stars
Quite an epic thiing u got here, we might use it in one of our animations one day ;)
Thank You. I am glad you enjoyed it.
Techno Swift
Rated 5 / 5 stars
I like it More!
Seems more better than the last 1 i heard.
Keep it up dude, I've grown a custom to your stuff..
thnxs man,
ive only done this as past time and im already enjoying making music more then ever
Techno Stream
Rated 5 / 5 stars
Funky!! Awesome!! Techno!!
I might be using this in some my moives in the future :D
nice work
Thanks man best thing ive heard so far
ill be looking out for ur work


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ANALYSIS from Michael Manley on how the favourites fared in each race at yesterday's Spring Carnival finale plus comments from their riders.
CRACK A ROADIE ($3.40 to $4.20) equal fav. 2nd
Jockey Craig Williams: "Really good run. He's going to be a nice horse next time in".
Manley: Finished strongly to just fail to grab the winner. Raced better than he did at Moonee Valley when he won. Will be better suited by 1200m next time in.
CITATIONS ($3.20 to $4.20) eq fav. 5th
Jockey Kerrin McEvoy: "Reasonable effort. He tried quite hard".
Manley: Looked in a reasonable spot but failed to finish it off. Fair effort.
GALAH ($2.50 to $3.20) fav. 2nd
Jockey Kerrin McEvoy: "Nice run".
Manley: Looked home with 200m to go but wast run down by Good Value. May have got there a bit soon, but had his opportunity.
SERTORIUS ($2.70 to $3.30) WON
Jockey Ryan Maloney: "He is still quite untapped and this preparation he has switched on and he is a lot more tractable. He has got that nice turn of foot when I need it".
Manley: Continued a fantastic preparation with yet another win. Meets every challenge. Controls his races and still looks as if he has something to learn. Should make a great stayer next time in.
GENERALIFE ($4.40 to $5) 4th
Jockey Kerrin McEvoy: "That was a good run".
Manley: Settled back in the field as expected. Looked to be coming into it nicely, but it was apparent with 250m to go when Gold Medal sprinted past him that he wasn't going to win.
SEA SIREN ($4.20 to $4) 2nd
Jockey Jim Cassidy: "She ran enormous. It was her first go down the straight and it would have been good to have a couple outside me, but it didn't happen. It probably helped the winner to sit off me".
Manley: Can't fault her performance. She is a star sprinter with more wins to come at the top level.
FAWKNER ($5 to $4.80) 2nd
Jockey Nick Hall: "Great run. He was brilliant. It's as good as it gets".
Manley: Given a perfect ride by Hall. Hit the front with 200m to go and then became part of the three-way dogfight. Dived again on the line but just failed. Has come along way this preparation.
SILENT ACHIEVER ($1.85 to $2) 4th
Jockey Hugh Bowman: "No excuses. Thought she would just win for most of the straight, but then she just didn't make an impression on them".
Manley: At the top of the straight when she pulled out she looked certain to win. Didn't produce her usual sprint and in the finish couldn't run a place in a disappointing effort.
Jockey Glen Boss: "I haven't had that feeling on a horse for a bloody long time, a really long time".
Manley: Seeing is believing. Produced the most exciting win of the carnival with a runaway, eased-down, five-length victory over a useful stayer. A star in the making.
TOKUGAWA ($4.40) 3rd
Jockey Damien Oliver: "He ran really well but dropping back to 1400m he just found them a bit sharp".
Manley: Settled mid-field. Oliver brought him into the race at the right time, gaining runs through the field. Kept coming but not fast enough to overhaul the leaders.
Originally published as How the favourites fared


text: Word Semantic Representations using Bayesian Probabilistic Tensor FactorizationJingwei Zhang, Jeremy Salwen, Michael R. Glass, Alfio Massimiliano GliozzoEMNLP2014Many forms of word relatedness have been developed, providing different perspectives on word similarity. We introduce a Bayesian probabilistic tensor factorization model for synthesizing a single word vector representation and per-perspective linear transformations from any number of word similarity matrices. The resulting word vectors, when combined with… (More)


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Values surveys and maps
A handy summary of the two values maps that we use in our work.
Why fundraise?
This provocation invites you to step back from the daily pressures of fundraising, to ask: why do it? It prompts readers to reflect on whether or not a charity has an obligation to consider the impacts of its communications on public support for other – perhaps very different – causes.
Summary of published research
This document presents a brief overview of the most important published research on the effects of engaging different values.
Reasons to volunteer
Map some the reasons for volunteering onto a spectrum, from the more extrinsic to the more intrinsic
Material tested in our experiments
This resource details some of the copy that we've used in experiments that we have conducted, testing the effectiveness of different charity communications.
Free gifts and supporter journeys
A fictional dialogue with a skeptical fundraiser, exploring some of the questions that we often encounter when exploring these issues with fundraising staff
Do you feel like a fraud?
This handout introduces a simple test to help decide whether a communication engages people as consumers or citizens.


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Cascade Collision Repair - Orem
Review for Cascade Collision Repair - Orem
Richard K. on 04/11/2011
Richard said the business personnel did a good job, but his vehicle was not ready when promised. Richard said it was three days late because there was a parts delay.
Category: Collision
Service Date: 04/06/2011
Review Created: 04/11/2011
This review was collected via phone interview by Customer Research Inc.


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Yes, even if you've been prudent enough to adopt a screen name that bears no relation to your legal name, list a public computer center as the sole address for your screen name, and just say no to using credit cards online, there are people nasty enough to steal your e-mail address...and use it to try to get money out of your friends and relatives in your name.
Here's an official notice for the benefit of all my friends and relatives: I, the writer known to cyberspace as Priscilla King, have never used e-mails to ask anyone for money, and don't intend to do so. I have linked things I've written only to online businesses and charities that I believe to be legitimately providing some sort of product or service in exchange for money they collect. This web site is a legitimate online business, or is intended to grow into one; if links or buttons haven't worked for you, that's because I'm a writer not a web designer--I intend them to work, and I intend to deliver something in exchange for your money.
The e-mail address that should display at the top of the page (email@example.com) will never legitimately generate any unsolicited e-mails asking you for money either. It's there for you to use if you want to send a personal comment about something on this site (without posting a comment for everyone else to read), especially if you have trouble using a "buy this book" or "support this site" button or following a link to some other web page. It's also there for you to send us a complaint immediately should you receive any unsolicited requests for money in any of our names. You should only ever receive instructions on how to send money to Priscilla King, Gena Greene, Grandma Bonnie Peters, or anyone else who may advertise on this blog, after sending an e-mail to Saloli about difficulties in purchasing products or supporting this blog while on this page.
It's not impossible that anyone involved with this web site may someday need money urgently; however, if any of us needs to borrow money from anyone we know personally, you will hear our real voices on the phone, if not see our real faces in front of you. And we will NOT ask you to disclose any personal or financial information on the Internet. We positively recommend that you not disclose personal or financial information on the Internet.
If you do receive e-mail from a screen name similar to ours, asking you to send money (even to one of us) when you have not notified us that you're trying to send money, here's an article that explains what you can do about this cybercrime:
Thursday, December 29, 2011
E-Mail Hackers
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text: Today, Harry, me and award winning video producer Art Bauer, will be brainstorming a viral video to promote Instant Turnaround! Our instructions are to think of something that's BIG TIME BIZARE and way, way,way outside the box. The video will be somewhere between 30 second and 3.5 minutes in length. If you have any ideas, please let me know this morning. Have a great day.


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Research in the area of stem cell biology and regenerative medicine, along with neuroscience, will further our understanding of drug-induced death of neurons during their development. With development of an in vitro model of stem cell-derived human neural cell lines investigators can, under control conditions and during intense neuronal growth, examine molecular mechanisms of various drugs and conditions on early developmental neuroapoptosis in humans. If the use of this model will lead to fewer risks, or identification of drugs and anesthetics that are less likely to cause the death of neurons, this approach will be a major stride toward assuring the safety of drugs during the brain development. The ultimate goal would be not only to find the trigger for the catastrophic chain of events, but also to prevent neuronal cell death itself.
The mechanisms of drug action and pathophysiology of various diseases are mostly studied in animals and need to be validated in human models. However, research efforts are hampered by limited access to human tissue, especially those that have not been exposed to disease, drugs, remodeling etc. For those reasons, many investigations are using derived human cells (i.e. neurons, cardiomyocytes, hepatocytes) from human embryonic stem cells (hESCs) or human induced pluripotent stem cells (iPSCs). This innovative, patient-specific approach is relatively new and was made possible due to seminal discovery in 2006 that terminally differentiated mouse somatic cells such as skin fibroblasts can be reprogrammed into a pluripotent state that is highly similar to embryonic stem cells (Takahashi and Yamanaka 2006). The resulting iPSCs are generated typically by transfer of reprogramming transcription factors, such as Oct4, Klf4, Sox2, and cMyc. Because iPSCs can be generated from any patient, including those with heritable diseases, iPSC studies offer the unique possibility of investigating the cellular consequences of various conditions or diseases by being able to investigate the genetic vs. environmental causes of altered phenotypic responses. That the above approach is going to be very useful comes from the results from recent studies showing, for instance, that iPSC-derived cardiomyocytes obtained from patients with long QT syndrome recapitulate the long action potential phenotype in cellular culture (Itzhaki et al. 2011, Moretti et al. 2010). Because neither traditional expression studies nor various animal models are able to faithfully mimic the human disease phenotype, this approach will help the investigators to model and examine, for instance, potential channelopathies associated with specific human mutations in cardiomyocyte lineages derived from patients with specific genetic mutations. Moreover, if the patient is unresponsive to conventional treatments, experiments conducted on patient-specific iPSCs have a great potential to discover mechanisms involved and the chance to formulate new and more effective drug therapies. Clearly, these innovative approaches have the capability to provide the necessary results and contribute to personalized medicine by identifying genetic-related disease aggravators, environmental confounding factors, and at the end, the beneficial therapies.
Because hESC and iPSC lines are capable to differentiate into various cell types, they represent a powerful experimental model to screen drugs and study normal and pathologic processes. Derived neurons and cardiomyocytes can phenotypically resemble functional human cells and have also been tested for cell replacement therapies. As in any new and emerging technology, there are expected variabilities between cell line to cell line such as pluripotent hESCs, iPSCs, mesoderm, ectoderm, and definitive endoderm that have been observed in microarray profiles. Moreover, there also appears to be significant heterogeneity in mRNA expressed in different hESC lines. In the future, one approach to better understand how changes in messenger RNA levels in differentiating stem cells and individual cell lines relate to cell function is to study changes in signal transduction and global changes in protein expression.( King CC 2010). In this brief review, potential developmental neurotoxicity of alcohol and general anesthetics are discussed with emphasis on the use of in vitro models of stem cell-derived human neuronal cell lines.
It is well-documented that alcohol abuse and dependency may lead to a fetal alcohol spectrum disorder (FASD). One of the most severe forms of FASD is the fetal alcohol syndrome (FAS) which is characterized by mental retardation, structural abnormalities, and microcephaly of the brain. Vast majority of studies using animal models and examining fetal alcohol toxicity indicate that ethanol exposure during the critical periods of intense synaptogenesis will lead to massive neuroapoptosis. These toxic effects of alcohol are due in large part to either block of NMDA glutamate receptors or activation of GABAA receptors in the developing brain (Ikonomidou et al. 2000). Not only are these neurotoxic changes secondary to acute alcohol exposure seen in rodent's brain, but also in the non-human primates (Farber et al. 2010). Using the primary neural progenitor culture from E14 rat embryos, it was reported that ethanol exposure suppressed the proliferation of neural progenitor cells and induced early differentiation of neurons (Kim et al. 2010). Other studies have shown that murine neural progenitors are relatively resistant to the apoptosis-inducing effects of ethanol (Prock and Miranda 2007). Using the rat model, the same laboratory also reported that ethanol promoted progenitor cell cycle progression and increased neurosphere number, without inducing apoptosis (Santillano et al. 2005).
Only a few studies have attempted to examine the effects of ethanol on hESCs or neuronal progenitors (NPCs) and effects of ethanol on these cells in the developing human brain are not yet clear. hESCs are pluripotent stem cells derived from the inner cell mass of human embryos at preimplantation stage. hESCs are able to replicate indefinitely and virtually differentiate into every cell type found in the adult body. The differentiation ability of hESCs into committed stem cells or specific lineages is potentially valuable for studying cellular and molecular events involved in early human development under physiological and pathological conditions. Recapitulation of neurogenesis from hESCs in vitro allows the investigations of drug-induced developmental neurotoxicity which are difficult to perform in humans. Multiple sequential steps are involved in hESC-neurogenesis and include differentiation of hESCs into NSCs with proliferation and differentiation potential, and differentiation of NSCs into neurons. This in vitro neurogenesis system mimics basal processes of brain development, such as cellular neuron differentiation. These processes might be disturbed by various drugs and anesthetics. Thus, using this in vitro neurogenesis system one is able to dissect the toxic effect of drugs on the hESCs, NSCs and developing neurons. Recent work has provided some unexpected new insights into how alcohol may cause additional damage to hESCs and NPCs (Nash et al. 2012). These investigators found a dramatic phenotype of proliferation in response to ethanol in hESC and NPC lines. Exposure to ethanol resulted in larger colonies of undifferentiated hESCs, despite an increase in apoptosis, because of increased proliferation of the undifferentiated cells and neuroblasts. These findings suggest more complicated cellular mechanisms of ethanol toxicity and spotlight the place hESC models have in helping to examine these mechanisms and complementing animal models of drug-induced developmental neurotoxicity. Clearly, this study points to a very promising approach by using hESCs to examine molecular mechanisms of various drugs and conditions of early developmental neuroapoptosis in humans.
Other investigators have examined the effects of ethanol on neuronal progenitors cells isolated from normal second-trimester fetal human brains (Vangipuram et al. 2008). The results indicate that ethanol induced a more rapid coalescence of progenitor cells and an increased volume of neurospheres, most likely due to an increase in cell proliferation as suggested in their subsequent publication (Vangipuram and Lyman 2010). Recent study used iPSCs to generate human neural cultures as a model system to examine the molecular actions of alcohol (Lieberman et al. 2012). These iPSCs were obtained from several alcohol-dependent subjects and several non-alcoholic volunteers. Consistent with previous findings acute ethanol exposure attenuated NMDA receptor response. In contrast the authors did not observe acute ethanol enhancement of GABAA responses which have been observed in some, but not all, reports using rodent neuronal cultures. This preliminary study also found that chronic alcohol exposure produced increases in mRNA expression of the NMDA receptor subunit genes only in cultures derived from alcoholic, but not non-alcoholic subjects. Although the results of this study are limited due to the small number of subjects, it is an intriguing approach of using patient-derived neural cells. It should provide a powerful model to examine cellular responses to acute or chronic alcohol exposure with respect to between-patient genetic variation. Although preliminary, the above study suggests that patterns of NMDA-mRNA expression maybe different in neural cells derived from alcoholic subjects. Indeed, as suggested by the authors, the heritable traits may lead to a more active alcohol-induced gene expression in the NMDA system in subjects predisposed to alcohol dependence and contribute to tolerance of the inhibitory effects of alcohol on the NMDA receptor activity. It is very likely that using the iPSC approach will give us an opportunity to study the functional effects on neuronal tissue of alleles that have been identified with risk for alcohol dependence.
Most of the studies on toxic effects of alcohol centering on NMDA receptor blockade and activation of GABAA receptors during the rapid brain spurt are drawing on parallel studies performed on chemicals and drugs that also block the NMDA receptor for glutamate and/or activate GABAA receptors. Indeed many groups have shown that most of the general anesthetics used today cause brain neurons to die by apoptosis during the active synaptogenesis (Stratman 2011). Either volatile or intravenous anesthetics suppress neural activity by also inhibiting NMDA receptors and/or activating the receptors for the inhibitory neurotransmitter GABA. It is likely that upregulation of excitatory receptors by anesthetics or alcohol leads to excessive calcium entry exceeding the buffering capacity of mitochondria followed by membrane potential depolarization, reactive oxygen species production, cytochrome c release into cytosol, and caspase activation, resulting in the neuronal apoptosis. Growing evidence in rodents and non-human primates has demonstrated that prolonged exposure of developing animals to general anesthetics (e.g., ketamine and isoflurane) could induce widespread neuronal cell death followed by long-term memory and learning abnormalities. For instance ketamine, an NMDA blocker, causes neurotoxicity in a variety of developing animal models (Braun et al. 2010, Slikker et al. 2007, Soriano et al. 2010, Takadera et al. 2006, Vutskits et al. 2006, Wang et al. 2006, Zou et al. 2009a, b), leading to a serious concern regarding the safety of pediatric anesthesia. In vitro experimental evidence from cultured neonatal animal neurons confirmed the in vivo findings (Takadera et al. 2006, Vutskits et al. 2006, Wang et al. 2006). Greatest vulnerability of developing brain to anesthetics occurs at the time of rapid synaptogenesis or so-called brain growth spurt period. Likewise, a few anesthetics might not be toxic at all, such as dexmedetomidine, because they do not affect the cellular receptors most commonly influenced by the majority of general anesthetics (Sanders et al. 2009).
While it is well-documented that exposure to general anesthetics during very active brain growth and formation of synapses in animals will result in considerable death of brain neurons and subsequent learning disabilities (Ben-Ari 2002, Chalon et al. 1981, Jevtovic-Todorovic et al. 2003, Olney et al. 2000), similar studies in humans are not feasible. There is a clear possibility that general anesthetics are also causing neuronal cell death in humans, although it is difficult to prove this definitively. Even more important is whether anesthesia impairs cognition in humans. Some epidemiologic studies in humans, although not all, have implicated that children exposed to anesthesia in early life have higher incidence of learning disabilities later in life (Davidson et al. 2008, Hansen et al. 2009, Loepke and Soriano 2008, Sun et al. 2008,). These and subsequent studies of multiple anesthetic exposures have shown to be detrimental for cognitive development of children, exhibiting significant delays in measured intelligence, adaptive functioning, and academic performance (DiMaggio et al. 2009, Flick et al. 2011, Kalkman et al. 2009, Wilder et al. 2009). In the United States millions of children are exposed annually to anesthetic agents that have been shown to cause neuronal cell death in immature animals, including non-human primates (Brambrink et al. 2010, Creeley and Olney 2010, Slikker et al. 2007, Zou et al. 2009a, b). In addition, up to 2% of pregnant women undergo anesthesia during their pregnancy for surgery unrelated to the delivery.
Nevertheless, if and how general anesthetics induce human neural cell toxicity is unknown. Recapitulation of neurogenesis from hESCs in vitro allows investigation of the toxic effects of anesthetics on hESCs, NSCs and developing neurons which is impossible to perform in humans. Using the hESCs my laboratory has recently examined the effects of clinically relevant concentrations of ketamine on proliferation and toxicity of hESC-derived NSCs and neurons (Bai et al. 2012, Bosnjak et al. 2012). These initial data indicate that similar to alcohol (Nash et al. 2012), clinically relevant doses of ketamine also increased human NSC proliferation and induced a time- and dose-dependent neuronal death. Ketamine also enhanced mitochondrial fission as well as reactive oxygen species (ROS) production compared with no-treatment control. Importantly, Trolox, a ROS scavenger, significantly attenuated the decrease of ketamine-induced cell viability.
In our study, following ketamine exposure at clinically relevant concentrations, there was a significant increase in the caspase-3 activity as well as TUNEL-positive cells with condensed and fragmented nuclei. The central components of the programmed cell death are a group of proteolytic enzymes called caspases which can be activated by various types of stimulation. Loss of ΔΨm and release of cytochrome c from the mitochondria are key events in initiating mitochondria-involved apoptosis (Budd et al. 2000). The released cytochrome c activates caspase-9, which consequently induces caspase-3 activation, resulting in the cleavage of several cellular proteins, and finally leading to the typical alterations related to cell apoptosis such as DNA fragmentation in cell nuclei (Braun et al. 2010, Zhang et al. 2010). Indeed we found that ketamine-induced neuronal apoptosis was accompanied by the significant decrease in ΔΨm and an increase in cytochrome c release from mitochondria into cytosol, suggesting that ketamine induces human neurons to undergo mitochondria-mediated apoptosis pathway. Mitochondria are highly dynamic and the alterations in mitochondrial shape (fusion or fission) can affect a variety of biological processes such as apoptosis and mitosis (Ong et al. 2010). Dynamin-related protein 1 (Drp1) is a fission-related protein, and with an overexpression of Drp1K38A that is a dominant negative mutant of Drp1, leads to prevention of mitochondrial cytochrome c release and apoptotic cell death (Frank et al. 2001). Our data showed the fragmented discrete punctiform mitochondria in the ketamine-treated culture, while mitochondrial shape was elongated with interconnected network in the control cells. Our initial data indicated that mitochondrial fission may mediate the ketamine-induced neuronal apoptosis by increasing ROS production.
To our knowledge, nobody has used this in vitro-controlled human stem cell-based neurogenesis model to address such important anesthesia issues and study mitochondrial fission/fusion dynamic- and autophagy-involved toxicity mechanisms. This approach has the potential translational application because identification of the cellular mechanisms and signaling pathways that underlie anesthesia-induced neurotoxicity will allow targeting of the molecules that can prevent this toxic effect. In addition, this established in vitro experimental model will provide numerous possibilities for future studies as one could use this high throughput approach to rapidly test the effects of various conditions and anesthetics on developing human neurons, which will lead to major advances toward assuring the safety of anesthesia for fetus and infant. As to the clinical practice, clearly more evidence is needed to guide clinical decision-making on the safety of anesthesia during labor and delivery as well as pediatric anesthesia. The National Center for Toxicological Research, an internationally recognized research center at the U.S. Food and Drug Administration, and several universities are conducting research regarding the effects of anesthetics on the nervous systems of animals during developmental periods of rapid brain growth (smarttots.org). Currently, there is not sufficient evidence to determine whether these findings are translatable to the millions of young children who receive anesthesia each year. Despite the unequivocal neurotoxic effect of anesthetics in animal models, there is no direct clinical evidence showing any such effect in fetuses, infants, and children at any dose. Without data from clinical studies, the question of whether anesthetic agents are neurotoxic in children cannot be answered.
Ultimately, if anesthesia is discovered to cause cognitive decline in developing human brains, we need to know how to prevent it by knowing the mechanisms of anesthesia-induced toxicity. Clearly, more research is urgently needed to determine whether anesthesia impairs brain function in human neurons, what the specific mechanisms are, and how it can be prevented. Research in the area of stem cell biology and regenerative medicine, along with neuroscience, will further our understanding of anesthetic-induced death of neurons during their development. With development of an in vitro model of stem cell-derived human neural cell lines investigators can, under control conditions and during intense neuronal growth, test the effects of different drugs including anesthetics on a developing human neuronal network. If the use of this model will lead to fewer risks, or identification of drugs and anesthetics that are less likely to cause the death of neurons, this approach will be a major stride toward assuring the safety of drugs during the brain development along with safe anesthesia and sedation for children. The ultimate goal would be not only to find the trigger for this catastrophic chain of events, but also to prevent neuronal cell death itself. It is of interest that some preliminary data showing evidence of lithium-mediated protection against ethanol neurotoxicity (Ishii et al. 2008, Luo 2010) is also seen in protecting the developing brain against the toxic effects of general anesthetics (Creeley & Olney 2010).
This work was supported in part by the National Institutes of Health Grants P01GM066730 and R01HL034708 (to Dr. Bosnjak), Bethesda, Maryland.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Maestros y Twitter en investigación profesional: JOLT – Journal of Online Learning and Teaching
Via Scoop.it – Botica
This research study provides new insight into how teachers use social networking sites, such as Twitter, as professional learning networks. The researchers surveyed and analyzed the public Twitter feeds of classroom teachers to determine the specific purposes for which teachers use Twitter. Study participants also completed surveys dealing with social networking. The K-12 educators in this study engaged in true dialogue, where evidence of actual conversation occurred in Twitter over 61% of the time. Additionally, over 82% of the time, the educators in this study chose to follow other educators or content experts related to their field of teaching so they were able to create a personal learning network meaningful to their professional needs. Analysis of data shows that a majority of tweets were educationally focused and were primarily in the categories of practice/philosophy, questions, and sharing of resources. Additional studies looking at how other online learning communities may be used as professional development venues would be beneficial and add to the knowledge base of online learning, professional development, and learning networks.
Via jolt.merlot.org


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Meta Search
search across all the following databases:
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Entire collection of data resources.
Opoid Use and Labor Force Participation
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a PSC Data Resource
Resource Source:William Robert Johnston
This site is a good clearinghouse for abortion statistics - US and world. He provides good annotation on his sources so that one can go back and follow up on statistics for a particular state (or country)Link:
Abortion Statistics (Source: William Robert Johnston)
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Did the World Bank Drive Tariff Reforms in Eastern Africa?
Summary This paper explores tariff reform in Ethiopia, Kenya, Tanzania and Uganda between the early 1990s and early 2000s. Tariffs were reformed in an across the board manner consistent with implementing World Bank programs: the average tariff was reduced and the dispersion of tariffs was compressed, with the highest tariffs being eliminated. There is limited evidence of political economy influences on the cross sector pattern of tariffs and reforms, except for a tendency to offer greater protection to larger manufacturing sectors in all countries except Uganda. The technocratic reforms have diluted relative protection and political economy influences in all the four countries.
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Volume (Year): 39 (2011)
Issue (Month): 3 (March)
Pages: 324-335
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References listed on IDEAS
Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- Santos-Paulino, Amelia U., 2002.
"The Effects of Trade Liberalization on Imports in Selected Developing Countries,"
World Development,
Elsevier, vol. 30(6), pages 959-974, June.
- Amelia U. Santos-Paulino, 2001. "The Effects of Trade Liberalisation on Imports in Selected Developing Countries," Studies in Economics 0110, School of Economics, University of Kent.
- Olivier Cadot & Jaime de Melo & Marcelo Olarreaga, 2015. "Lobbying, Counterlobbying, and the Structure of Tariff Protection in Poor and Rich Countries," World Scientific Book Chapters,in: Modeling Developing Countries' Policies in General Equilibrium, chapter 13, pages 295-316 World Scientific Publishing Co. Pte. Ltd..
- Olivier Cadot & Jaime de Melo & Marcelo Olarreaga, 2004. "Lobbying, Counterlobbying, and the Structure of Tariff Protection in Poor and Rich Countries," World Bank Economic Review, World Bank Group, vol. 18(3), pages 345-366.
- Hiau Looi Kee & Alessandro Nicita & Marcelo Olarreaga, 2008. "Import Demand Elasticities and Trade Distortions," The Review of Economics and Statistics, MIT Press, vol. 90(4), pages 666-682, November.
- Kee, Hiau Looi & Nicita, Alessandro & Olarreaga, Marcelo, 2004. "Import Demand Elasticities and Trade Distortions," CEPR Discussion Papers 4669, C.E.P.R. Discussion Papers.
- Hiau Looi Kee & Nicita, Alessandro & Olarreaga, Marcelo, 2004. "Import demand elasticities and trade distortions," Policy Research Working Paper Series 3452, The World Bank.
- Arne Bigsten & Mulu Gebreeyesus, 2009. "Firm Productivity and Exports: Evidence from Ethiopian Manufacturing," Journal of Development Studies, Taylor & Francis Journals, vol. 45(10), pages 1594-1614.
- Bigsten, Arne & Gebreeyesus, Mulu, 2008. "Firm Productivity and Exports: Evidence from Ethiopian manufacturing," Working Papers in Economics 303, University of Gothenburg, Department of Economics.
- Grossman, Gene M & Helpman, Elhanan, 1994. "Protection for Sale," American Economic Review, American Economic Association, vol. 84(4), pages 833-850, September.
- Grossman, G.M. & Helpman, E., 1992. "Protection for Sale," Papers 162, Princeton, Woodrow Wilson School - Public and International Affairs.
- Grossman, Gene & Helpman, Elhanan, 1993. "Protection for Sale," CEPR Discussion Papers 827, C.E.P.R. Discussion Papers.
- Grossman, G.M. & Helpman, E., 1992. "Protection for Sale," Papers 21-92, Tel Aviv.
- Gene M. Grossman & Elhanan Helpman, 1992. "Protection For Sale," NBER Working Papers 4149, National Bureau of Economic Research, Inc.
- C. Milner & O. Morrissey & N. Rudaheranwa, 2000. "Policy and Non-Policy Barriers to Trade and Implicit Taxation of Exports in Uganda," Journal of Development Studies, Taylor & Francis Journals, vol. 37(2), pages 67-90.
- Foroutan, Faezeh, 1993. "Trade reform in ten sub-Saharan African countries : achievements and failures," Policy Research Working Paper Series 1222, The World Bank.
- Richard M. Auty & Oliver Morrissey, 1995. "Politics and economic policy reform: Trade liberalization in sub‐Saharan Africa," Journal of International Development, John Wiley & Sons, Ltd., vol. 7(4), pages 599-618, 07.
- Nash, John & DEC, 1993. "Implementation of trade reform in sub-Saharan Africa : how much heat and how much light?," Policy Research Working Paper Series 1218, The World Bank.
- Oliver Morrissey & Chris Jones, 2008. "Missed Opportunities: The WTO Trade Policy Review for the East African Community," The World Economy, Wiley Blackwell, vol. 31(11), pages 1409-1432, November.
- Amelia Santos-Paulino & A. P. Thirlwall, 2004. "The impact of trade liberalisation on exports, imports and the balance of payments of developing countries," Economic Journal, Royal Economic Society, vol. 114(493), pages 50-72, 02.
- Oliver Morrissey, 2004. "Conditionality and Aid Effectiveness Re-evaluated," The World Economy, Wiley Blackwell, vol. 27(2), pages 153-171, 02.
- Jiandong Ju & Yi Wu & Li Zeng, 2010. "The Impact of Trade Liberalization on the Trade Balance in Developing Countries," IMF Staff Papers, Palgrave Macmillan, vol. 57(2), pages 427-449, June.
- Greenaway, David & Morrissey, Oliver, 1993. "Structural Adjustment and Liberalisation in Developing Countries: What Lessons Have We Learned?," Kyklos, Wiley Blackwell, vol. 46(2), pages 241-261.
- Oliver Morrissey, 2005. "Imports and Implementation: Neglected Aspects of Trade in the Report of the Commission for Africa," Journal of Development Studies, Taylor & Francis Journals, vol. 41(6), pages 1133-1153. Full references (including those not matched with items on IDEAS)This information is provided to you by IDEAS at the Research Division of the Federal Reserve Bank of St. Louis using RePEc data.


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1. Where's your hometown and what brought you to Sarasota?
I am a native of Sarasota. I moved away for college and received a greater appreciation for my hometown while away. The quote, "You never know how much you'll miss something until it is gone" became a reality for me when I moved away. Shortly after graduating I made a decision to move back, which has been one of the best decisions I ever made!
2. What is your favorite thing about Sarasota?
I love the small town feeling I get. I love the small town family owned restaurants. I love the fact that nothing in town is more than 20 minutes away. More than anything, I love that I live just minutes away from the nation's #1 beach!
3. Tell us a little bit about yourself... (Hobbies, interests, work)
I absolutely love dancing. It doesn't matter where, it can be in a night club, at a dance studio, or in my bedroom at home while cleaning. I also teach private dance classes when I am not working at my primary job.
4. Why did you feel that YPG would be a good fit for you and what is your favorite aspect so far?
When I attended my first Icebreaker as a non-member I received the warmest welcome from every single person. What I loved the most that day and what made me join YPG was the amount of motivation that I received from every individual I spoke with to pursue my personal goals as a young professional. As a native of Sarasota, it was refreshing to see young, like-minded individuals wanting to succeed just as I do. I thought it was important that I join YPG so that I could contribute my knowledge and perspective of Sarasota being that I have lived here practically all my life.
5. Any word of advice for other young professionals moving to the area?
Don't be afraid to get involved. "F.E.A.R is only false evidence appearing real." If you get over your fears you will discover a new world of possibilities. The more you get involved within the community the more you'll discover, and the more you discover the more people you meet and the more people you meet, the more you'll feel at home.
1. Where's your hometown and what brought you to Sarasota?
I am originally from Buenos Aires, Argentina, and I came to the States on a work visa back in 2007. Since then I had an opportunity to become a permanent resident and lately, a proud U.S. citizen. I started my journey on the east coast of Florida. However, five years ago life brought me to Charlotte County where I currently reside. Very often I would travel to Sarasota to enjoy Siesta Key, the different restaurants, and activities that the town had to offer. I always had so much fun and met very nice people which made me start planning to move to Sarasota. I want to make this beautiful and exciting town my own home.
I love Sarasota because it is a medium size town that has a lot to offer. I love to participate in cultural events, and I love to try different types of cuisine. Sarasota has both, and many choices to choose from. As an example, I recently had an opportunity to experience my first Opera, and I was ecstatic about the performance and quality of the show I went to see at the Sarasota Opera house.
3. Tell us a little bit about yourself? (Hobbies, interests, work)
I love to travel. I enjoy meeting new people, seeing beautiful places, and trying different food. I currently work with the county government in Charlotte County, but I am looking for new job opportunities in Sarasota County. I am also graduating this coming May with an A.S. in Computer Science from State College of Florida, and my mom is coming from Argentina to celebrate. We have a trip planned to go to New York while she is in the States. I am so excited because it will be her first time!
I heard about Young Professionals through a friend. I thought it would be a perfect fit to meet like-minded professionals in the city I love. So far, I had meet a lot of wonderful people that were very welcoming and friendly to me. I also had the opportunity to participate in various volunteer events which were an excellent way to give back to the Sarasota community. I like that YPG also offers ways to be actively involved in the community and voice what we would like to see for the improvement of the town.
Sarasota is an up and coming town that has a lot of fun things to do. Siesta Key is one of the top ten beaches in the world! Companies are also moving to the area and creating a bigger pool of jobs. If you are moving to the area, be sure to check out our YPG events. You will not be disappointed. There are always friendly and approachable people that will welcome you to their town and help you feel at home.
1. Where's your hometown and what brought you to Sarasota?
Born and raised in beautiful Sarasota.
2. What is your favorite thing about Sarasota?
There is always something to do here. Sarasota is where urban amenities meet small-town living!
1. Where's your hometown and what brought you to Sarasota?
My native home town is New Orleans. It's a great place, with food, fun, and extremely friendly people. I came to Florida to help my mom run her business. It's a private vocational school called GUTI The Premier Beauty & Wellness Academy. The work of helping her business was big draw to relocate, but also being closer to her was an added incentive. She's my best friend.
2. What is your favorite thing about Sarasota?
Apart from the gorgeous beaches, the weather, the elegance, and events, my favorite thing is the possibilities. Coming from a larger city, I'm grateful that in a city like Sarasota the sky is the limit of what you can accomplish. Getting involved, specifically becoming a leader has much less barriers to entry than in larger communities. It's such a refreshing opportunity that all young professionals should be excited to take advantage of. I would encourage everyone to find something you're passionate about and lead.
4. Why did you feel that YPG would be a good fit for you and what is your favorite aspect so far?
YPG has been an excellent fit for me because of the incredible opportunity to serve. I've also been humbled by the wealth of talented and intelligent and dedicated young men and women right here near me. The members I serve with on the board as well as the entire YPG membership are quite easily some of the most amazing people I've met in my life. I've made some great friendships, received terrific colleagues/partners for business, and have truly given back to my community. It's been a pleasure.
5. Any word of advice for other young professionals moving to the area?
1. Where's your hometown and what brought you to Sarasota?
A job brought me to Sarasota! In 2011 I graduated from the University of Missouri and got my first job out of college at the Observer Media Group. Iowa City, Iowa is my hometown.
2. What is your favorite thing about Sarasota?
My favorite thing about Sarasota has been the opportunity to reinvent myself. I can't really speak in comparison to other cities, but I do know that I have gotten the chance to discover my interests on both a professional and personal level, which has been invaluable to my growth and development as a person.
3. Tell us a little bit about yourself? (Hobbies, interests, work)
I work as the Content Coordinator for Visit Sarasota County. In that position I get to write, photograph, film and create graphics for the tourism bureau to fulfill their content needs. I also play a role in facilitating essentially anything content-related, including social media campaigns and contests. Our newest of which (shameless plug) is #mysarasota!
Outside of work I do much of the same things — creating videos, photography, writing — so I guess I've really found what I love to do. I also play soccer and try to maintain an active-lifestyle.
4. Why did you feel that YPG would be a good fit for you and what is your favorite aspect so far?
I thought YPG would be a good fit for me because I sought to connect with people my own age and level of professional development. I like to believe that you can never know never know who you might meet and how big a role they might have in your life, so it's always good to try new things! My favorite aspect so far has just been the social hours and gatherings.
5. Any word of advice for other young professionals moving to the area?
I feel super cheesy saying this, but I do actually think it's incredibly important, which you will come to understand more and more as you settle into Sarasota:
Start thinking how you want people to think about you — and stand by the standards you set for yourself. I always try to be friendly, sincere, and responsive, even when I feel I am treated disrespectfully — you never know who your next boss might be, and you can't understand someone's motives until you've spent a some time with them. Be proactive about trying new experiences just for the sake of meeting new people.
Stay connected with Sarasota Area Young Professionals via our Facebook page. Come check out photos from past events, gets information about future events and share stories about your SRQ experience as a young professional!
As a program of The Greater Sarasota Chamber of Commerce, the YPG must rely on sponsorship of Chamber Member businesses in order to help fund our professional development, networking programs and initiatives. Annual Sponsorship is a great way to support and reach the young professionals in the the community while gaining exposure for your business or organizations.


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I was just saying to someone the other day, "How can anyone be undecided at this point? The election is two weeks away!" Fortunately, David Sedaris put it much more eloquently (and humorously) in the New Yorker:
I don't know that it was always this way, but, for as long as I can remember, just as we move into the final weeks of the Presidential campaign the focus shifts to the undecided voters. "Who are they?" the news anchors ask. "And how might they determine the outcome of this election?"
Then you'll see this man or woman— someone, I always think, who looks very happy to be on TV. "Well, Charlie," they say, "I've gone back and forth on the issues and whatnot, but I just can't seem to make up my mind!" Some insist that there's very little difference between candidate A and candidate B. Others claim that they're with A on defense and health care but are leaning toward B when it comes to the economy.
To put them in perspective, I think of being on an airplane. The flight attendant comes down the aisle with her food cart and, eventually, parks it beside my seat. "Can I interest you in the chicken?" she asks. "Or would you prefer the platter of shit with bits of broken glass in it?"
Look, I can understand being conflicted (even if I think the choice is high-definition clear). I don't know who to root for in the World Series between the Phillies and Rays. So you have two more weeks to figure it out.
But do the undecideds just want attention, like "Joe the Plumber"? (Okay, that's probably a bad example.) Or does that "undecided" really mean something else when it comes to Barack Obama? (I hate being that cynical.)


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Firingoti Trailer (1992)
01 January 1992 Drama, History 117 mins
The story is set in 1962, the time of Sino-India war. It revolves around a widowed teacher named Ritu who is transferred to Koronga, a small Assamese village. The school here was destroyed by fire ten years earlier. Ritu takes on the challenge of rebuilding the school and starts campaigning among the villagers.
Watch the official Firingoti 1992 trailer in HD below or find more Firingoti videos on Vidimovie.


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Looking for help with pictures
I am hoping that maybe some kind soul out there can help me with a project I am working on. I am looking for the pictures of the following people: Lois Alberta Daggett, Charles Austin Daggett, Oren Henry Daggett, Hartwell Oren Daggett and Parmelia Holliday Daggett. The name of Oren Henry Daggett's wife and a picture of her would be great also. Thank you for any help that you can give to me on this...it is really appreciated.


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finol (79) Stockholm, Sweden | August 12, 2014
This is not a bad place to have dinner if you are in the area, but it have no place on this site with one craftish brew on tap and a handful on bottle. Most restaurants in Stockholm have a better lineup these days.
tomashanzon (9) , Sweden | April 19, 2012| Updated June 7, 2012
Really nice place with a decent selection of beer. Has Christoffel which is always nice. Some good american beers too. Excellent food if you want a solid burger, with a knife right through it..


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Zed Build Guide by Natasumi
Not Updated For Current Season
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Roaming Death Mark
Zed Build
Ability Sequence
Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Threats to Zed with this build
|This is an easy gank because when syndra is jumped there is nothing she can do and will usaul most likely always blow a flash if not die.
At the beginning Zed jung can only be used to help push out/pressure lanes and harass unless you team has a lot of cc to set him up with a gank pre six. But once you hit level six as soon as you gank as long as your opponent is not feed you will defiantly get a kill (saying that don't go tower diving a le blanc because you will just fallow her all over the place).
Zed jungle is also useful if the rest of your team is ap as late game you will be an equivalent of a mid or top zed so you will provide the same damage and even if you cannot provide the super insec lee sin kick easily helping win a team fight is just as good.
Now these runes make it so much easier to farm the jungle as the life steal just stop you from taking as much damage therefore if you want you can take a ward instead of two of you starting pots. Also the extra attack damage given will give you that extra damage to clear the buffs quicker and you will generally be more efficient.
With items you start almost like a vi just with elder lizard you don't do a great amount of damage till you it level 6 but when you get your brutalizer you become much stronger and this makes it easier to get kills. late game once you have 6 items you can swap out your lizard for a G.A or a Q.S.S which could be more useful. Also you could even swap your bots and then just rely on the speed up from youmuu's just get you around the map. only get the hexdrinker when you are against ap because a randuins would be much more useful against a full ad team.
Skill Sequence
On the way I have levelled up my abilities is your Q is the best for poke and clearing the jungle same for your E but your Q scales better that is why you level it up first. On the other hand you could level up your E instead for better jungle clear but yo would not have the same burst potential till later on into the game.
Zed is just a fun champ to play in the jungle who can gank easily with his clone and can be played top jung or mid. Thank you for reading!
P.S SKT Zed is the best!!!


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Brittany Billmeyer-Finn is a poet and playwright living in Oakland, CA. She is the author of the full length title, the meshes from Black Radish Books. During her 2015 residency at SAFEhouse Arts in SF she directed her first play, the meshes an iteration in 2 acts. Her work has been published locally in Where Eagles Dare, Elderly, in the anthology; It is Night in San Francisco but It's Sunny in Oakland, 580 Split, Hold: A Journal & her chapbook geraniums is published by Mondo Bummer. She has a forthcoming chapbook, Slabs coming out with the Tract Series from Timeless Infinite Light. More of her work can be found online at The Poetic Labor Project & Dusie #15.
Born in Manapla, Philippines, Cheena Marie Lo is a genderqueer poet based in Oakland, CA. They coordinate a youth art program at California College of the Arts, and co-edit the literary journal HOLD. A Series of Un/Natural/Disasters is just out from Commune Editions.
Kate Robinson is a writer and book artist living in Oakland, CA.


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911 is saved for emergencies only. Not that there aren't plenty of calls that are fielded by the dispatchers that aren't emergencies. But none will probably ever beat this call.
Billy Nolin is a 5 year old living in Florida. When he woke that morning, he called 911 to ask for the deputies to come eat Thanksgiving dinner with them! His short message was simple: "Will you come over because we are having Thanksgiving. Thank you, bye." His message was fielded by the operator, but he hung up before he could get a response. Afterwards, he admitted to his mom what he had done.
While his mother was not very happy her son had called 911 for something that wasn't an emergency, she couldn't be too angry with Billy's sweet heart. Instead, Lani simply told him that he can't use that number for something that isn't an emergency.
Two deputies got wind of the phone call from Billy, and decided to go and pay the boy a visit. They thanked him for his kind offer for them to join the Thanksgiving meal! Damon Byrd and Aaron Etheridge were the two deputies that decided to answer the call. As soon as they arrived, Billy began to cry because he was worried he would be in trouble! He thought the cops were going to arrest him! Instead, when they thanked Billy for the offer, and told him they thought it was very sweet of him to invite them! They even let him sit in the patrol car.
After the two deputies left, Lani posted on the sheriff's Department Facebook page and told them that Billy had told her he wanted to be a police officer, so that he could do for other boys what those two deputies did for him! The kindness of two police officers may have changed the life of this little boy, simply by showing up.Share on Facebook


text: Darcy Laceby Food Development and Innovation BSc (Hons) I originally applied to do a psychology degree at another university but I changed my mind. At school, I did an Extended Project Qualification in psychology and got bored. I changed my EPQ to write a cook book and loved it. I decided I wanted to do something I enjoyed rather than something purely academic and the Food Development and Innovation course really appealed. I wanted to do something businessy but also food related so that is why I chose this course rather than Culinary Arts Management. I am interested in going into food marketing or buying rather than becoming a food development chef. I love the course. It is so closed-knit and we are all friends. Because UCB is a small university, there is more of a community. You don't feel you are just a number. Our lecturers are lovely. If you have an idea they will take it on board. Food Development and Innovation is such a broad course. I want to go into business but I am not really sure where, so it is good to get a broad view of the industry and the opportunities. "I love the course. It is so closed-knit and we are all friends. Because UCB is a small university, there is more of a community." Undergraduate College of Food A-Z of Courses Open Days UCB Tours How to Apply Making your Application After you Have Applied Clearing Glossary of Admissions terms UCAS Tariff Calculator Fees, Funding and Scholarships Home/EU Students International Students Scholarships and Fee Waivers Student Life Accommodation Term Dates (Calendar) Erasmus+ Exchange hired@UCB Transferring from another university Student Handbook Awards Congregations Online Galleries Request a Prospectus


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The Ride Trailer (1994)
13 September 1994 Drama, Comedy, Romance 90 mins
Two guys bought a car and travelled through the country untill they met a lonely girl on the road. So they begin to travel together having so much fun. And there is another guy who has a better car and who is looking for the girl because he is her lover, he is her first one. What is going on inside of this girl? Nobody knows, until the end.
Watch the official The Ride 1994 trailer in HD below or find more The Ride videos on Vidimovie.


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What kind of bank jobs PO / Clerk can I apply after 12th and Graduation
What kind of bank jobs PO / Clerk can I apply after 12th and Graduation
bank clarical
if u have more than 60percent mark in graduation u can apply both clerk and po
just u can apply for sbi clerk
Bank exams are for two entry levels: clerical cadre and probationary officer (both after graduation). Currently you are not eligible to write the clerical exam or PO exam. Therefore if you want to write the probationary officers exam, you will have to graduate. You can also study for B-school entrance exams and opt for an MBA in finance. This is advisable as you wont be totally dependent on success in the bank exam, as an MBA diploma gives you wider choice.
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stand in line (especially on 99 cent taco wednesday)
order two fish tacos "con todo"
get a seat and get some condiments. watch out for those yellow peppers, dont want to damage your taste buds!
retrieve tacos from the window when your number is called.
squeeze lime on taco then pick up and bite
after your eyeballs are done rolling to the back of your head, continue.
you may feel the need to roll into fetal position and just hold yourself for a moment. but this is not the 90s and youre not at a rave. so hold it together!
last step: wipe away tears of joy...
option: order a third and fourth
special notes: look for the tantalizing neon green colored fast food restaurant. thats where youre headed.
special personal technique: i usually ask for just one corn tortilla per taco so i can eat the maximum number of tacos. means to an end baby!
also, just a block over on atlantic there is a crazy abandoned theater/church building. i love that place...
Tacos Baja Ensenada
5385 Whittier Blvd.
Los Angeles, CA 90022
(323) 887-1980
(a few minutes east of downtown)


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More interview questions
View family photos
Concert photos and friends
Read the Driftwood Magazine profile story.
Barry is interviewed by Stefan Shepherd of Zooglobble.
I've been writing ever since I was in elementary school. My first story was called The Ten O'Clock Alarm Clock that Would Not Stop and I wrote it when I was eight years old. It was about a man who kept getting fired from all his jobs because his alarm clock always rang late --at ten o'clock. I didn't write that story to be published--I didn't even write it for school. I was writing for fun. And you know what? Even though I make my living as a writer, I still write for fun. I love all the different ways we have to tell the stories of our lives.....in books, songs, poems and film. Since that first story, I've written hundreds of songs, poems and books. You can read my first story in the "Other Writings" section...if you promise not to laugh!
I was born in Brooklyn, New York. My family moved to the Washington, DC area when I was about eight years old and I've lived in Maryland ever since.
Yes. One is a picture book called Five Pennies To Spend and it's about a boy who is sent to the store for some bread and is given five pennies to spend on himself (back when five pennies could actually buy something!) On the way, he meets many desperate animals who need basic, simple things just to survive. When he gets to the store he eyes the lollipop he really wants but instead buys food and supplies for those animals he encountered en route. He distributes it to all the animals on the way back and when he gives his mother the bread, she finds the lollipop for her son at the bottom of the bag from the shopkeeper. It's a great story and I never forgot it.
My other favorite is The Party Pig, a story about a little pig who is having a birthday party. When his mother leaves for the store to pick up some last minute things, he is visited by many different animals from the farm and each has a sad tale to tell; the hen will be slaughtered if she doesn't give eggs; the cow will be taken away if she doesn't give milk. Of course, the party pig empties out his entire pantry and invites them all to his party that afternoon. When his mom returns, she discovers that he has given away all the food and there is no way to have a party for him. But when the guests arrive, they have each made food with part of the ingredients they had borrowed from him.
Actually, I saved these books and still have them. I read them to my kids when they were little and I am sure they influenced me when I was young. In fact, I think the book Ferdinand The Bull probably influenced an entire generation. It's about a bull who refuses to fight in the arena and all the bullfighters keep trying to provoke him but all he wants to do is sit and smell flowers. Eventually they return him to the fields. Another story I remember was about Scuppers, the Sailor Dog. The illustrations were really vivid.
I liked to read and to write, but I never thought I would make my living as an author or songwriter for children. I went to college to be a teacher and while I was in college, I was invited to a school to perform. I sang some songs I had written and the kids nearly fell out of their seats with laughter. When the show was over, a dozen kids came up to me and wanted to know how I wrote my songs and where I got my ideas from. Within minutes, a teacher came up to them and began yelling at them, telling them to be quiet and to get back in line. "Wipe those grins off your faces," she said, "you're acting just like children." I quickly wrote down everything she said and went home that night and wrote a song about a mean teacher. I sang the song at another school a week later.
Not long after I wrote the song about the mean teacher, my phone started ringing. "Is this Barry Louis Polisar?" I would hear. "Is it true you wrote a song about a mean teacher?" "Yes," I would say sheepishly. "Well, I'm a teacher and I want to know if you can come to my school and sing that song." I never expected that would happen, but it's a true story and led to my career. I don't sing that song too much anymore because--as everyone knows--they don't make mean teachers anymore!
When I wrote that song about the teacher, something else happened. I realized that I could write about everyday experiences. I could write about my younger brothers and sister, parents, grandparents, uncles, aunts and cousins. I would be over my family's house for dinner and my mom would try to get my younger brother to eat his food by comparing his plate with mine. "Look," she would say, "Barry ate all his vegetables, why can't you be that way?". I remembered being compared to the older boy that lived next door and I went home that night and wrote another song --He Eats Asparagus, Why Can't You Be That Way?
I write a lot about my own family and friends. I like to find the humor in everyday life and write about it. With an uncle who lived in a tent and a mother who owned twenty-seven cats, I figure I know how funny everyday family life really can be. People think I make a lot of this up, but I really do get many of my ideas from my own family.
Art: Radioactive Cats copyright by Sandy Skogland
When my kids were younger, I wrote many songs about them. One song I wrote when they were babies is called Diaper Rash. When they got a little older I wrote another song based on our lives at the time; it's called Potty Training. I think it's important to know that you can use the creative process to write about anything from your own experience.
Sometimes it takes years. I spend a lot of time working on my books and songs. I don't just write the first thing that comes to me; instead I write and re-write and revise my stories, poems and songs over and over.....In my school programs I talk a lot about all the rough drafts I do on my work.
Yes. My job as a performer and author takes me all over the country--and even to Europe. I've played at The White House, The Smithsonian Institution, The John F. Kennedy Center for the Performing Arts and in hundreds of schools just like yours.
I live in Maryland with my wife, my daughter, my son, a dog, and a cat. Our kids are older now--all grown up! My daughter did the funny artwork for the cover of my last CD when she was in fifth grade. My son began playing clarinet when he was in elementary school and joined me on my last CD, playing clarinet and saxophone. When I'm not writing or performing, I like to ride my bike along the bicycle trails near my house and since we live next to the Patuxent River, I enjoy kayaking next door.
No! A few years ago, we bought a house on 16 acres near the Patuxent River --but it wasn't a mansion. In fact, I spent a few years fixing up the house and cleaning the land; hauling away over two hundred old tires, a dozen junked cars, half-buried trash, rusty scrap metal, and collapsed and rotting buildings. My kids thought I had a new job; driving around in a beat up old pick-up truck hauling away junk every day. You can read about this project and see "before and after" pictures in the "Tireless Efforts" story in my "Other Writings" section. Kids always want to know if I live in a mansion. The real story is even better.
Yes! I recently finished three new books now -- one is a new poetry book on fish. I wrote a chapter book about the Amistad slave rebellion that I started twelve years ago and I also published a 2-CD recording of my worst songs...that's right: The worst of Barry Louis Polisar! It was fun taking my failed songs and rewriting them into totally new and different works.
You can listen to all my songs right on my web site. I hope you can find my CDs and books right in your local library--or maybe even in your own school.
More interview questions: Barry talks about movies, books and music


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Автор: Nivaldo J. Tro
Раздел: Pearson
|Под заказ. Поступление на склад 20.12.2017
This innovative, pedagogically driven text explains difficult concepts in a student-oriented manner. The book offers a rigorous and accessible treatment of general chemistry in the context of relevance. Chemistry is presented visually through multi-level images - macroscopic, molecular and symbolic representations - helping students see the connections among the formulas (symbolic), the world around them (macroscopic), and the atoms and molecules that make up the world (molecular). Among other revisions, the Second Edition offers a crisp new design, adds more challenging problems, and significantly revises coverage of electrochemistry.
Цена 36 920 тг. за 1 штКоличество


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Memphis Grizzlies small forward Rudy Gay (22) is held back by coach Lionel Hollins during the first half of game 4 of the Western Conference Playoffs at Staples Center in Los Angeles on May 7, 2012. UPI Photo/Lori Shepler
United Press International is a leading provider of news, photos and information to millions of readers around the globe via UPI.com and its licensing services.
With a history of reliable reporting dating back to 1907, today's UPI is a credible source for the most important stories of the day, continually updated - a one-stop site for U.S. and world news, as well as entertainment, trends, science, health and stunning photography. UPI also provides insightful reports on key topics of geopolitical importance, including energy and security.


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CASA joins state-wide efforts in PENNSYLVANIA AND VIRGINIA TO PROTECT VOTERS ON Election DayPosted November 7, 2016 /
WASHINGTON D.C. (November 7, 2016) CASA, the immigrant-based organization that has been fighting for the Latino and minority community since of since 1986, will work to safeguard voters at the polls who may be victims of intimidation or harassment in Pennsylvania and Virginia on Election Day.
"We feel this is work of the upmost importance during these elections when our election process has been called into question," said Executive Director Gustavo Torres. "We will make sure that voters who are are registered and have a right to vote are able to exercise their right if that right is called into question."
In past weeks, some have questioned the integrity of the elections by calling the system "rigged" and encouraging supporters to question the integrity of the vote.
Now CASA, as a member of the Election Protection coalition in
Pennsylvania and the Virginia Civil Engagement Table, will provide on-site voter assistance to prevent voter intimidation.
More than 20 CASA staff and volunteers will participate with on-site voter assistance in Lancaster, York and Harrisburg. They will stand outside of polling stations to provide help, answer question or help people report intimidation, if it occurs.
This is part of a state-wide effort with hundreds of organizations in different areas from Western and Central Pennsylvania to Philadelphia.
The conversation about rigging and fraud is a distraction that is weakening our democracy. The biggest concern that voters have about Pennsylvania's election process is a lack of participation.
WHAT IS THE PLAN TO PROTECT PENNSYLVANIA'S ELECTIONS AND VOTERS? Through a hotline and via on-site voter assistance, the Election Protection coalition works to ensure every eligible voter can cast a ballot that counts.
- The Election Protection coalition met with many county and state elected officials to ensure a smooth election process. If there are problems on Election Day, legal field teams will be ready to work with these officials to address problems or incidents.
- On Election Day, teams of legal and grassroots field volunteers monitor the precincts where problems may be more likely to occur, checking in on each one.
- On-call attorneys will be available in all of Pennsylvania's counties to take immediate legal action when warranted.
- Intimidation can be reported the Election Protection coalition (866-OUR-VOTE) which coordinate with District Attorneys' offices and election officials. Election Protection volunteers can also form a barrier between intimidators and the poll entrance to prevent harassment.
In Virginia, CASA members and volunteers will be part of a state-wide effort by the Virginia Civil Engagement Table.
The coalition will station about 300 volunteers statewide wearing "866-OUR-VOTE" T-shirts at polls statewide to answer questions. The group also staff offices in Norfolk, Richmond and Northern Virginia with lawyers and experts who can consult with volunteers. CASA will have volunteers in Prince William County.
The group has offered its services since 2000, but this year could pose a special challenge.
"Politicians in both parties never want to hear it when Americans reject their political agenda," Torres said. "So instead of listening to the will of the American people, they cry fraud or allege the systems is rugged instead."
These will be CASA's locations for poll watching on Election Day:
Woodbridge Middle School
2201 York Drive, Woodbridge, VA 22191
R Dean Kilby Elementary School
1800 Horner Rd, Woodbridge, VA 22191
Stonewall Middle School
10100 Lomond Dr, Manassas, VA 20109
Yorkshire Elementary School
7610 Old Centreville Road, Manassas, VA 20111
If you have questions, you can call the group at 866-OUR-VOTE. For response in Spanish it's 888-VE-Y-VOTA
Communications Manager – CASA
Cel. 240.706.262


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As expected, the internet imploded this lunchtime after the first trailer for Fifty Shades of Grey was released.
Jamie Dornan and Dakota Johnson star in the upcoming movie adaptation of EL James's erotic novel, and the trailer has received a rather mixed reaction.
Some felt a certain sense of dread:
Man if 50 Shades of Grey is a movie that spoofs the sad premise that a woman needs a man to give her worth, then this trailer is KILLING IT.
— Anne T. Donahue (@annetdonahue) July 24, 2014
Can someone please summarize 50 Shades of Grey for me in a tweet.
— Khaela de Leon (@khaela) July 24, 2014
Fifty Shades of Grey looks like it might actually be a bit sexist, based on the trailer. I haven't read the books.
— Jack Seale (@jackseale) July 24, 2014
I thought 50 Shades Of Grey was a romantic movie? Why does he try to kill her at the end with the whips and hand cuffs?
— manuel (@MANUELCAV) July 24, 2014
So theres a 50 Shades of Grey movie now too, and Emma Watson isn't in it? Not interested.
— Nspire Apex (@xApexPred) July 24, 2014
So it turns out it is actually possible to make a movie so unappealing that no amount of shirtless Jamie Dornan will make me want to see it.
— Steven Perkins (@stevenperkins) July 24, 2014
While others couldn't control their excitement:
Fifty Shades Of Grey - Trailer
— abajeans (@akosiabajeans) July 24, 2014
Fifty Shades Of Grey - Trailer . I mean, honestly, the books are SHIT and utterly boring but i'm still looking forward for the movie.
— LEA NATHALIA FOX (@nathaliafoxx) July 24, 2014
Ok fifty shades of grey trailer is perfection I'm in love all over again with Christian Grey
— Oarmen Coi âœŒï¸ (@CarmenGotSwagg) July 24, 2014
Jamie Dornan doesn't look as hot in the 50 Shades trailer as he does in The Fall. This makes me very sad. Bring back the beard!
— Lucy Mapstone (@MSNLucyMaps) July 24, 2014
Most people seem to be in agreement that Beyoncé's new version of 'Crazy in Love' is pretty good:
Beyoncé was the only thing that really mattered in the 50 Shades trailer. Nothing more.
— Ryann Reyes (@ryannreyes) July 24, 2014
Best thing about the #FiftyShadesOfGrey trailer is definitely the angsty remix of @Beyonce's 'Crazy in Love' https://t.co/YAC0uvVAwC
— Daniel Sperling (@DSDS1989) July 24, 2014
The #FiftyShades trailer was... cool & all, but I just want to know when I can get that exclusive version of Crazy in Love x Beyoncé.
— ΔSH THE JEWELER (@xoASHLEI) July 24, 2014
Fifty Shades of Grey's supporting cast features Rita Ora, Marcia Gay Harden, Max Martini, Eloise Mumford and Jennifer Ehle.
The film will be released in cinemas on Valentine's Day 2015.


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OfficeMax Loss Narrows on Reduced Write-Downs
OfficeMax Inc.'s quarterly loss narrowed on much smaller write-downs compared with a year earlier.
Chairman and Chief Executive Sam Duncan said the No. 3 U.S. office-supply retailer expects to post sales growth in 2010, upbeat compared with analysts' estimates for 1.7% sales decline, according to Thomson Reuters.
Mr. Duncan added OfficeMax was pleased with its improvement over the last year "in what has remained a tough...


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I am experiencing stomach aches for a week now.
Patient : My stomach has been hurting for a week now and it started when i had my period but it's still hurting even though my period has ended. Is it possible that I have UTI?
Symptoms: Stomach aches
Doctor : This question is currently in queue and will be answered shortly by one of our doctors. In the meantime you may browse our library of answered questions by clicking here.
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I'm looking into converting to a 1x9 setup on my epic. The bb mount chainguides can't be used and the seat tube ones can't be used either. Has anybody made some type of chainguide work?
OR does anybody know if Specialized will be selling the DMD 1x10 chainguide that is on the 2011 epic EVO?
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Thread: 2011 Epic 1x9 chainguide


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February 3, 2017 | Category: Announcement
TO: Faculty and Staff, All campuses
Tufts Crowdfunding is an online platform to help Tufts students, faculty, and alumni raise money for Tufts programs or initiatives through their personal networks and communities. Projects on this platform promote innovation and community impact across the university and catalyze transformational projects. It works like Kickstarter or Indiegogo, but is exclusively for the Tufts community.
Visit the Tufts Crowdfunding website to see current projects. This is the pilot phase of Tufts Crowdfunding, and the goal is to learn, with a larger public launch on April 1st.
Applications are now being accepted for projects to crowdfund in April 2017. Any interested project teams can apply online now.
Interested in crowdfunding or have any questions or comments? Contact Tessa Buckley, Assistant Director, Digital Fundraising and Direct Marketing, at firstname.lastname@example.com