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DPM Breakup Model
Hi everybody!
I am trying to model the transient injection of gas that causes the dispersion of solid particles whose initial velocity is 0 m/s. The gas will lift the solid particles and will reduce its pressure and velocity during the dispersion process.
The particles are fragmented dutring the dispersion process. So I included the breakup Wave model.
When I don't use the breakup model the convergence is very good, but, if I activate it the calculation diverges after 9 ms. However, it is necessary to include the particles fragmentation in the simulation.
This is some information about my simulation:
Boundary conditions: Velocity inlet with varying profile and pressure outlet with fixed value
Fluent V13
Turbulence model: RANS RSM and LES
Iterations/Time step: 40
Particle size: Between 26 and 86 µm (600000 particles aprox with Rosin-Rammler distribution)
Number of mesh elements: 483188
Minimum element size: 8.5e-4 m
Maximum element size: 3.0e-3 m
fluent time step: 1 ms
Solid particles time step: 0.01 µs
Please, give me your comments and suggestions
Hello Carlos,
Did you try to set a lower Time Steps and a higher number of iterations/time step?
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i'm a beginner at all of this craft stuff, and i decided to try out sewing. however, i have recently discovered that i am extremely needle-illiterate. therefore, i am going to buy an inexpensive sewing machine just to see how well i fare with it (if i really get into it, i will buy a decent one, but for now the key word is 'cheap'). but i don't know anything about sewing machines, so how do i know if i'm getting a good deal?
i ask the experts, that's how!
i would really like some feedback on two machines i found at target. numero uno, numero dos. any and all comments are highly appreciated!

subset: commoncrawl


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I just got the following from our test manager Mike who is totally hip to the blogs. I am passing this on because:
- It is great to see that people are saying cool things about our product
- We are listening to your feedback and doing whatever we can to make the product better. �
With that being said here is the feedback:
- Day 8 of Microsoft Office 2007 - just like in Office 2003, OneNote stands out as the most innovative program.
- OneNote: Product Management Super Tool - it's probably the most useful piece of software I've ever owned�
- While I'm handing out praise, I should say that I find Microsoft OneNote, part of Office 2007 to be a really useful piece of software.�
- OneNote review: "Random thoughts of a young mother"
- I am pleased to announce the availability of the English Standard Version Bible for OneNote 2007�
- Office 2007 Beta 2 works amazingly well with Vista. This is the bright spot in the experience. OneNote, especially, shines.�
- OneNote Napkin Math - I noticed this little gem over at the IW Center�
- OneNote is great...I'm going to use it all the way through my PhD �
- OneNote 2003 was a great tool...but he needed to use some other tools to publish the entry on his blog. Now, you can do everything in OneNote! Isn't that exciting
- Top 10 Microsoft Things
Thank you all and please keep it coming!


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For the first time in years, I am loving the Orioles bullpen.
I loved them when they broke camp. I thought it was almost perfectly constructed, given the personnel on hand and they are performing admirably.
Over the past 14 years of losing, the bullpen has ranked among the worst in baseball, year in and year out. Sure, there were a couple of exceptions, but Orioles bullpens of the aughts and beyond have generally provided the proverbial gasoline on the starting staff's fires.
Not in 2012. The bullpen has posted a 2.26 ERA, third-best in the American League, and leads have felt safer than they have in more than a decade.
Leading the way is the new closer, Jim Johnson. Johnson, a homegrown Oriole, took over the ninth-inning duties late last season and has cemented himself in that role this season. Johnson has been the best bullpen arm for a few seasons now but the team kept looking outside the organization and paid big money to so-called proven closers Mike Gonzalez ($12 million over two seasons) and Kevin Gregg ($10 million over two seasons).
Gonzalez produced just two saves during his stay, Gregg has saved 22. Johnson has converted 16 saves in just about two months on the job and leads the league with seven saves in 2012. So much for needing a proven closer. Jonson's been a bit lucky to have not given up an earned run this season but when hitters are hittng grounders 68.2 percent of the time they put it in play, you'll make your own luck.
Then there are the pair of fireballers, Pedro Strop and Matt Lindstrom. Both boast 95 mph fastball and pile up the strikeouts. Both have a K/BB ratio of 3.00 or above. Both came to Baltimore via trade; Strop was the player to be named when the O's shipped the aforementioned Gonzalez out to Texas and Lindstrom came from the Rockies with Jason Hammel for Jeremy Guthrie. And they lead all Oriole relief pitchers in WAR for the young season. You have to like the chances of these strikeout artists coming on in the seventh or eighth and getting the ball to Johnson in the ninth.
Darren O'Day, another former Ranger, has been utilizing his wicked slider to fool hitters this season. He leads the team in swinging strike percentage (12.9 percent), first-pitch strike percentage (67.9 percnt) and swing percentage of pitches thrown outside of the strike zone (36.5 percent). His fastball has averaged just 84 mph in 2012, but he's managing to get strikes at Strop-like rates.
Luis Ayala is doing the same thing he has done for eight seasons: slider, changup and a two-seam fastball. Ayala can still get his fastball up over 90 mph, limits his walks and keeps the ball in the park.
Troy Patton is the last man left in the organization from the original Miguel Tejada trade. He has battled injuries ever since, but I was pulling for the guy this spring training. He pitched well late last season and I think he has the talent to be an excellent and versatile reliever for the Orioles. All he needs are big league innings and health. Patton has struggled a bit early but his xFIP is pretty good (4.16 xFIP) and he has limited his walks. I think we're going to see good things from this lefty as the season progresses.
The elephant in the room is Gregg, the highest-paid reliever on the team. He's been awful. O's relievers have given up 13 earned runs this season; Gregg has given up five of them. He's walked more than he's struck out and all the advanced pitching metrics suggest that he is just as bad as his traditional stat line says. The silver lining to this is that Gregg will either get much better, quickly, or he will be released.
And if Gregg is released, who takes his place? There are a lot of good arms at Triple-A Norfolk and many are pitching well. If you want to bring up a long man, Dana Eveland, Steve Johnson and Jason Berken are all pitching well in the Tides' rotation. And out of the 'pen, Zach Phillips, Pat Neshek, Miguel Socolovich ans Miguel Gonzalez all have had some early success.
It's a relief corps not built around high-priced free agents but a mix of inexpensive veterans, homegrown talent, waiver claims and PTBNs. And it's refreshing to see.
Heath Bintliff blogs about the Orioles at Dempsey's Army. His ruminations about the Birds appear as part of MASNsports.com's season-long initiative of welcoming guest bloggers to our site. All opinions expressed are those of the guest bloggers, who are not employed by MASNsports.com but are just as passionate about their baseball as our roster of writers.


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Need to know the opening times for Lloyds in Chulmleigh? This is the bankopeningtimes.co.uk page for the Lloyds in Chulmleigh branch. Here you'll find address details, telephone number and map location.
Find the exact location of Lloyds in Chulmleigh with Google Maps - click the map to zoom in and out and find out where the Lloyds in Chulmleigh branch is located.
Search for another Lloyds branch
Whether you're at work and need to find your nearest branch, or need to know if Lloyds in Chulmleigh is open on Saturdays, Bankopeningtimes.co.uk is a UK bank directory with details for local branches across the UK.
The bank details listed here for the Lloyds in Chulmleigh branch are for guidance purposes. We recommend you ring the Lloyds, Chulmleigh branch before visiting to confirm any enquiries.
There are likely to be a number of Lloyds branches in your surrounding area - use bankopeningtimes.co.uk to find out if Lloyds in Chulmleigh is your nearest branch.
Edit Details
Help us keep the UK Bank directory as up to date as possible. If you know that any of the address details or opening times for Lloyds in Chulmleigh are incorrect or have changed, please let us know by clicking on the following link:


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Al-Qa'ida kills 66 in bomb blitz across Iraq
TERRORISTS launched co-ordinated bomb attacks on 14 cities in Iraq yesterday.
At least 66 people were killed and more than 240 wounded in the 17 bombings, which were blamed on al-Qa'ida.
It was the country's bloodiest day of the year, underlining the fragility of security less than five months before American troops are scheduled to complete their withdrawal.
Iraqi security officials said al-Qa'ida affiliates were trying to destabilise the government of Nouri al-Maliki, the prime minister, although there was no immediate claim of responsibility for the attacks.
The scale of the violence demonstrated insurgents' continued ability to strike, despite a series of security crackdowns.
Iraqi and American officials have questioned the ability of the Maliki government and security apparatus to deal with the insurgency after US troops leave.
Two weeks ago, Iraqi leaders agreed to open talks with Washington over retaining a military training mission beyond the year-end withdrawal deadline.
Major General Qassim al-Moussawi, a spokesman for security operations in Baghdad -- which was hit by three separate bombings -- blamed groups linked to al-Qa'ida.
"These attacks . . . are trying to influence the security situation and undermine confidence in the security forces," he said.
The worst carnage was in the southern city of Kut, more than 100 kilometres south-east of the capital, where two bombs in quick succession struck a market area at 8am, killing 40 and wounding more than 65.
The first was in a fridge holding cold drinks, a local police official said. When rescuers and onlookers crowded around in the aftermath, a car bomb was detonated.
The deaths provoked accusations of incompetence against Mr Malaki and his security forces. Ali Jumaa Ziad, a shopkeeper close to the scene, said: "Where is the government with all these explosions across the country? Where is Maliki? Why doesn't he come to see?"
Theodore Karasik, a Middle East security expert at the Dubai-based Institute for Near East and Gulf Military Analysis, suggested al-Qa'ida in Iraq was trying to disrupt the government and send a message to the Americans.
"It seems that al-Qa'ida in Iraq is playing a propaganda game. At the same time it's trying to show that it can still carry out deadly violence," he said.
"If the US extends its military presence, al-Qa'ida in Iraq can use it as a tool by saying, 'Look, the Americans have reversed their decision to leave and are staying on as occupiers'. They could use this as a justification for more attacks."
All American forces are scheduled to leave Iraq by the end of this year, in line with a 2008 security deal agreed by Baghdad and Washington.
The US has offered to keep as many as 10,000 troops in Iraq to help train the country's security forces, but such a deal would be difficult to accept for many Iraqis tired of eight years of American presence. (© Daily Telegraph, London)
Irish Independent


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Faculty and Staff Newsletter
Center news, grants and funding, comings and goings and more…
Faculty and Staff Directory
A listing of all Faculty and Staff associated with the Center for Agriculture, Food and the Environment.
Planning and Reporting
CAFE Faculty and staff will find links and resources related to MAES and Extension planning and reporting in this section.
Center and Extension Logos
Logos for the Center for Agriculture and for Extension are available in either print or web format.
Civil Rights Information
The Center for Agriculture, Food and the Environment and UMass Extension maintain and promote policies to prevent discrimination or bias in their programs and in their employment. You will find information employees here on required statements to be included on public printed and web-based information, our mailing list policy and a link to additional information provided for public and employee benefit about Civil Rights protection in Center programs.
Farm Research and Event Requests
Requests to utilize the Crop and Vegetable Research and Education Center in South Deerfield for research projects and Extension/outreach events should be submitted using the appropriate form below.
Desktop, Software and Equipment Support
Center for Agriculture and Extension staff as well as Extension Faculty and related colleagues may make use of the technology support services detailed here.
Web Design and Development
Resources and guidelines for developing a web presence.
Web Hosting
Information on Drupal hosting policies for CAFE related websites.
Online Services Support
Online conferencing, conferencing registration, Google Analytics, email marketing solutions, email listservs, online sales portal (include Bookstore portal service in this category)
Drupal Training and Support
Training for editing content on a Drupal website and downloadable pdfs of Drupal instruction manuals.
UMass Library Resources
You can utilize this library resource directory for materials useful in agricultural research and to reach the Agriculture Librarians.
National Resources
Links to agencies and programs related to the mission of the Center for Agriculture, Food and the Environment.


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Prepare for Festapalooza With the 5 Best Filter Songs
Filter will rock Shreveport, Louisiana on September 14 at the 99X/Redd's Apple Ale Festapalooza, powered by Bossier City Harley Davidson. Make sure you don't get left in the dust by brushing up on lyrics from some of Filter's best songs so you can sing along at the show.
Here's our list of the 5 best Filter songs to get you prepared for this kick-ass rock fest!
Take a Picture
This is from the 1999 album "Title of Record" and stands out as one of the most unique songs in the band's history.
It's a laid-back, feel-good song you can sing along with and the vocals are less gravelly in this one. There are probably only a few people who haven't heard it.
What Do You Say
It's the first single off their brand new album "The Sun Comes Out Tonight" and one we're currently rocking on 99X. You'll hear it many more times before Festapalooza gets here, but the official video for it will help hammer those song lyrics into your brain.
Hey Man Nice Shot
From the 1995 self-produced debut album "Short Bus," it's one of the band's most recognizable tunes. It's dark, moody and features the scream-y vocals Richard Patrick is known for.
Food for thought: the number of times the song title has been used by sports fans and hunting enthusiasts is likely in the billions.
(Can't You) Trip Like I Do
This is a reworking of "Trip Like I Do," a song featured on The Crystal Method's debut album "Vegas."
The track was recorded for the 1997 film adaptation of the "Spawn" comic book series. Co-written by Filter, the song and accompanying video featured the band and its signature vocals and guitars. Check it out.
Another tune off the "Short Bus" album. It's got that filtered (see what we did there?!) megaphone-style vocal sound to it that was popular in the 90s. Oh, and it's a seriously rockin' song in its own right.


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Covert Ops - Beta
This quest is not available in game.
Retrieve the Venture Co. Letters from Windshear Mine at the east end of Windshear Crag.
- Venture Co. Letters
- Covert Ops Pack (Provided)
Plan Beta's just like Plan Alpha, <name>.
We cause a distraction and then steal their precious letters.
The key is to get their letters... remember that.
The pages I gave you already will tell you where to plant the explosives. Just get back here alive and with those letters....
You will also receive:
- 350 reputation with Gnomeregan


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(file opens in new tab)
Oliggo-Fiber™ Instant Inulin Clinical Studies
Study #1
"Oligofructose treatment increases satiety following breakfast and dinner, reduces hunger and prospective food consumption following dinner. This pilot study presents a rationale to propose oligofructose supplements in the management of food intake in overweight and obese patients."
[P.D. Cani et al, Oligofructose promotes satiety in healthy human: a pilot study, European Journal of Clinical Nutrition (2006) 60, 567–572. doi:10.1038/sj.ejcn.1602350; published online 7 December 2005]


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Cash, Paper, and Electronic Payments: A Cross-Country Analysis
The social cost of a payment system comprises between 1% to 1.5% of GDP. This cost can be reduced if non-cash payments shift from paper to electronics since the cost of an electronic payment is estimated to be from one-third to one-half that of a paper-based transaction. We examine the use of cash and five non-cash payment instruments in 14 developed countries over 1987-1993. Our purpose is (1) to outline the current use of check, paper giro, electronic giro, credit card, and debit card payments and (2) to determine why some payment instruments are used more intensively than others, especially electronic versus paper-based payments. Standard demand theory influences (own price and incomes, institutional factors, and simple availability measures across countries are examined, as is the effect of habit formation. Payment substitution relationships are also estimated and indicate that checks will decline with further growth of electronic payments while the instruments that make up electronic payments will tend to expand together rather than replace one another. Copyright 1996 by Ohio State University Press.
If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
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Volume (Year): 28 (1996)
Issue (Month): 4 (November)
Pages: 914-939
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ThemeForest Fount One & Multipage Hybrid Wordpress Theme 8112414
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The article offers brief information on the editorial board of Trenchless Australasia which include principal engineer in Sydney Water Sudipta Basu, associate director in AECOM New Zealand Ltd. Maurice Lubbock, and graduate of Melbourne Metro Rail Authority Annie Louey.
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- Pearpoint. // Underground Construction;Jul99, Vol. 54 Issue 7, pR-5
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Recounts an accidental spill of gasoline wherein closed-circuit television cameras from Pearpoint were employed to locate the source of the leak. Features of the Pearpoint P494 Pan and Tilt Camera and Pearpoint P571 cameras; Information about the spill.
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The article previews the pipeline inspection systems and camera vans from Pearpoint/SPX.


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By Christen Nehmer | June 19, 2011 9:02 am Follow @FoodChannel
In a perfect world, your Thanksgiving day goes exactly as planned, in the real world, you don't always get so lucky. Mistakes and (…)
Reinvent and amp up the traditional cheeseball this holiday season with this delicious cheeseball made of cream, blue and cheddar cheese (…)
Thanksgiving can be a time of stress, especially if you're hosting others on the holiday. There are so many things to remember! (…)
Cheese balls are a holiday staple for most families, but no one wants to create the same recipe year-after-year! If that's you, then (…)
This delightfully different brittle is the best tasting sweet treat that everyone will enjoy this year! The flavor and texture of the (…)
Small Bites When someone mentions the words 'seaweed' or 'algae,' some of the thoughts that come to mind are sushi, (…)
Ask The Chef The following question came into The Food Channel: Question: How soon can I start baking (…)
Although Grapenuts were first produced in the late 19th century, within the next couple of years, these little grains were used as a (…)
The holiday season is an exciting time for family to come together and share tradition, love and food, and for some cocktails! So, whether (…)
Bonfire night in the U.K. has to be one of our favorite nights of the year. With the early darkness, falling leaves, and smell of cordite in (…)


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Written on: 18/05/2013
These really are the best beans I've ever had! Excellent value for money, fabulous tomato sauce, smooth consistency, holds the beans well and not to sweet. Every single bean was the right firmness. No hard beans or mushy ones! They maybe best eaten warm, but I've just polished off two cans cold!! I will certainly be stocking up on them, and telling my parents about them.... They shop in Waitrose, but I have introduced my Mother to the true gem that is Aldi and she rather likes it, although the fact that they don't take credit cards made her laugh! Why do Aldi always seem to be getting everything so right at the moment and the big fella's are failing? Not that I care, if I won the Lottery, I'd still shop at Aldi....... well, they have the BEST BAKED BEANS....EVER!!!
As rated by our community of reviewers
" Shadow of their former self! " Read More
Written by Foodyfarmer
" Horrible! " Read More
" ALDI Corale Baked Beans 425g Made in Italy " Read More
" BRING THEM BACK! " Read More
" 2 sml pieces of Chicken!!! " Read More


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Circa 1880 apothecary cabinet pulls with space for nameplate. Sold as a set of four.
The dimensions are 3.25 in. L x 1.375 in. W.
**NOTE: Before purchasing directly through PayPal, please inquire about item availability and please wait for invoice to be emailed to you BEFORE paying directly. Often, an item has been sold quickly & not taken off yet or shipping prices have to be adjusted. Thank You!
Your source for Architectural Antiques & Altered Antiques
Industrial, altered antiques, doors, hardware, farm tables, tin mirrors and panels and mantels.


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The Slipper Room Show
Bastard Keith, Kira Fath, Carla Rhodes, Raquel Reed, Corvette LeFace, Dirty Martini
Fri, January 13, 2017
Doors: 8:00 pm / Show: 9:30 pm
The Slipper Room
New York, NY
$15 (advance) – $20 (door)
Tickets at the Door
This event is 21 and overhttps://www.slipperroom.com/event/1392682/
The Slipper Room Show - (Set time: 9:30 PM)
A special evening of the best NY talent in the world of Burlesque, Variety, Magic, Sideshow & Circus performance.
*Ticket price includes Midnight Show*
Set times are 9:30pm, 10:30pm, 12am &1am
*Ticket price includes Midnight Show*
Set times are 9:30pm, 10:30pm, 12am &1am
Kira Fath
Contortion and aerial artist based in NYC.
Carla Rhodes
CARLA RHODES is the world's foremost (and only) rock'n'roll ventriloquist. Mentored by the legendary Shari Lewis, Carla has performed since her teens and appears regularly in New York City when not touring nationally. Unfortunately, you've most likely seen her cantankerous sidekick CECIL SINCLAIRE in the gutter, not looking at the stars.
Raquel Reed
NY Burlesque Performer
Corvette LeFace
NY based burlesque performer
Dirty Martini
New York, Slipper Room & international burlesque superstar Dirty Martini. Star of Cabaret New Burlesque, the movie Tournée, & Miss Exotic world to name only a few of her achievements!
Tonight Dirty graces the Slipper Room stage!
Tonight Dirty graces the Slipper Room stage!
Venue Information:
The Slipper Room
167 Orchard St
New York, NY, 10002
The Slipper Room
167 Orchard St
New York, NY, 10002


text:
Posts Tagged 'bail bonds los angeles ca'
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text:
Discussion in 'Android Devices' started by tnbassman, May 10, 2010.
just received my Dinc and it is now charging. Any tips for how to endure the wait?
Skin pop a nice warm batch of dragon.
Use it, it will still be charging
Go onto appbrain.com and start browsing all the apps you want to download. You can even put them all into your own personal list on the website so you can see them all in one place once you get you phone up and running.
Fap to pictures of Scarlett Johansen.
Use it while it's charging, nothing bad will happen.
Then when it turn's green, turn the phone off and charge it again. It will go back to orange/red and then will take another 20+ minutes (on the wall) to get the last 10%.
You will have to do this every time for a full charge (turn phone off for last 20+ min via wall charger).
Post stupid questions on this forum?
Take a cold shower?
I just turned mine one and used it while charging. Batteries are cheap enough for me to not worry about cycling or any of that nonsense.
Just use it. Initial charge isn't going to effect your battery life much, contrary to popular belief.
play this stupid but for some reason incredibly addictive game. >_<
Turn it on and try and try to top my score of 8900 points on RoboDefense.
rub one out
Read the manual?
Bubble Strugle 2
Play that game, trust me by the time your Incredible is done charging you will be so pi$$ed trying to beat levels on that game you will forget Android even exists.
Get into a debate about should you or should't you use Advanced Task Killer.
How the hell do you make that idiot run? I'm pretty good at making him flip over and land on his head. Is there really a way to make him run or is it a gag?
I managed to make him skip like a fairy for 10 meters!
I got 2 meters then stopped before I threw computer out window.
I have no idea. I got him to like 20m on his knees once, but it was boring as all hell.
I'm @ 28 meters, this is stupid and boring, but doesn't make me want to throw it out the window, click W/O and then click QP....you just keep doing it in those combos and you can go forever...
Laugh at those of use who dont have one yet


text:
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Van Cleef Arpels 18k Ladies 0.20ct Diamond Solitaire Ring - Size 5.25
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text:
Tafenoquine/Chloroquine DDI Study
This study has been completed.
ClinicalTrials.gov Identifier:
First Posted: March 30, 2009
Last Update Posted: June 19, 2017
Medicines for Malaria Venture
Information provided by (Responsible Party):
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
DDI study of Tafenoquine and Chloroquine
|Drug: Chloroquine, Tafenoquine Drug: Placebo
|Phase 1
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Other
|Official Title:
|Safety, Tolerability, and Pharmacokinetic Study of Concomitant Chloroquine and Tafenoquine in Healthy Volunteers
Resource links provided by NLM:
Drug Information available for: Chloroquine phosphate Chloroquine Chloroquine sulfate Chloroquine hydrochlorideU.S. FDA Resources
Further study details as provided by GlaxoSmithKline:
Primary Outcome Measures:
- TQ and Chloroquine (Day 2): AUC(0-tau), Cmax and Tmax [ Time Frame: 56 days ]
- CQ and TQ (Day 3): AUC(0-tau), AUC(0-inf), Cmax, Tmax and t1/2 [ Time Frame: 56 days ]
- AEs, vital signs, 12-lead ECGs, telemetry, clinical laboratory and ophthalmic assessments [ Time Frame: 56 days ]
Secondary Outcome Measures:
- QTcF, QT, QRS, RR and HR as assessed by 12-lead ECG [ Time Frame: 56 Days ]
- Changes from baseline in QTcF [ Time Frame: 56 days ]
|Actual Study Start Date:
|March 24, 2009
|Study Completion Date:
|August 26, 2009
|Primary Completion Date:
|August 26, 2009 (Final data collection date for primary outcome measure)
|Assigned Interventions
Active Comparator: Part 1
Tafenoquine + Chloroquine vs. Chloroquine alone
Drug: Chloroquine, Tafenoquine
Chloroquine and Tafenoquine
Other Names:
Placebo Comparator: Part 2
Chloroquine alone, Tafenoquine alone or Chloroquine+Tafenoquine
Drug: Chloroquine, Tafenoquine
Chloroquine and Tafenoquine
Other Names:Drug: Placebo
Other Name: Placeob
Detailed Description:
Safety, Tolerability, and Pharmacokinetic Study of Concomitant Chloroquine and Tafenoquine in Healthy Volunteers
Information from the National Library of Medicine
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years to 55 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Healthy as determined by a responsible and experienced physician, based on a medical evaluation including medical history, physical examination, laboratory tests and ECGs. A subject with a clinical abnormality or laboratory parameters outside the reference range may be included only if the Investigator and GSK medical monitor agree that the abnormality will not introduce additional risk factors and will not interfere with the study procedures.
- Male or female between 18 and 55 years of age inclusive, at the time of signing the informed consent.
- A female subject is eligible to participate if she is of non-childbearing potential or of child-bearing potential if has a negative urine pregnancy test at screening and Day -1, and agrees to use agreed upon contraception methods until 56 days after stopping study drug.
- Body weight >=60 kg (132 pounds) and BMI within the range 19-32 kg/m2 (inclusive).
- Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form
Exclusion Criteria:
- A positive urine drug/alcohol screen at screening or Day -1.
- History or regular use of tobacco- or nicotine-containing products within 3 months prior to screening.
- History of illicit drug abuse within 6 months prior to screening.
- History of regular alcohol consumption within 6 months of the study
- Subjects who are unwilling to comply with the lifestyle guidelines required.
- The subject has participated in a clinical trial and has received an investigational product within the following time period prior to the first dosing day in the current study: 30 days, 5 half-lives or twice the duration of the biological effect of the investigational product (whichever is longer).
- Use of prescription or non-prescription drugs, including vitamins, herbal and dietary supplements (including St John's Wort) within 7 days (or 14 days if the drug is a potential enzyme inducer) or 5 half-lives (whichever is longer) prior to the first dose of study medication.
- History of sensitivity to any of the study medications or their components.
- Where participation in the study would result in donation of blood or blood products in excess of 500 mL within a 56 day period.
- Pregnant females as determined by positive urine hCG test at screening or prior to dosing.
- Lactating females.
- Subject is mentally or legally incapacitated.
- A positive HIV antibody, Hepatitis B surface antigen or positive Hepatitis C antibody result within 3 months of screening.
- The subject's systolic blood pressure is outside the range of 90-150mmHg or diastolic blood pressure is outside the range of 45-90mmHg or heart rate is outside the range of 50-100bpm for female subjects and 45-100bpm for male subjects at screening and Day -1.
- Cardiac conduction abnormalities as specified inprotocol
- Any significant arrhythmia which, in the opinion of the principal investigator and GSK medical monitor, will interfere with the safety for the individual subject.
- History of angina, ischemic heart disease, myocardial infarction, or clinically significant arrhythmia.
- History of epilepsy, convulsions or psychological disorders.
- History of porphyria.
- AST, ALT or alkaline phosphatase >1.5 times the upper limit of normal and/or total bilirubin level outside the normal range at screening. A single repeat is allowed for eligibility determination.
- Documented Glucose-6-phosphate dehydrogenase (G6PD) deficiency, determined by a quantitative assay of enzyme activity.
- History of hemoglobinopathy; or current or past history of methemoglobinemia or methemoglobin percentage above the reference range at screening.
- History of previous eye surgery involving the retina, Lasik surgery within 90 days, or retinal/corneal abnormalities.
- Any clinically significant abnormalities on the screening Humphrey 10-2 visual field test.
- Best corrected visual acuity worse than 0.3 logMAR (20/40 Snellen equivalent) (i.e., 20/40 or better vision will be allowed on study).
Contacts and Locations
Information from the National Library of Medicine
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00871156
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00871156
|United States, New York
|GSK Investigational Site
|Buffalo, New York, United States, 14202
Sponsors and Collaborators
Medicines for Malaria Venture
|Study Director:
|GSK Clinical Trials
More Information
Additional Information:
Keywords provided by GlaxoSmithKline:
Additional relevant MeSH terms:
Additional Information:
Miller AK, Harrell E, Ye L, Baptiste-Brown S, Kleim JP, Ohrt C, Duparc S, Möhrle JJ, Webster A, Stinnett S, Hughes A, Griffith S, Beelen AP. Pharmacokinetic interactions and safety evaluations of coadministered tafenoquine and chloroquine in healthy subjects. Br J Clin Pharmacol. 2013 Dec;76(6):858-67. doi: 10.1111/bcp.12160.
|Responsible Party:
|ClinicalTrials.gov Identifier:
|NCT00871156 History of Changes
|Other Study ID Numbers:
|First Submitted:
|March 23, 2009
|First Posted:
|March 30, 2009
|Last Update Posted:
|June 19, 2017
|Last Verified:
|June 2017
Keywords provided by GlaxoSmithKline:
Drug-Drug Interaction
Additional relevant MeSH terms:
Chloroquine diphosphate
Antiprotozoal Agents
Antiparasitic Agents
Anti-Infective Agents
Antirheumatic Agents
Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Inflammatory Agents
Antinematodal Agents


text: Have a chicken and a big hunk of pork butt, going to shove an onion in the chicken and truss it up, the pork is getting a cumin, coriander, celery seed, turmeric, and salt rub. I love to grill on my Weber. It's small enough to not be a hassle and big enough for me to cook enough meat to last a week in the fridge.


text:
Mos Eisley Cantina Benches Pack
In Stores
Wouldn't we all love us a new Lego Mos Eisley Cantina for in our Lego Star Wars Galaxy?
A Mos Eisley Cantina which isn't as small as the Lego Set 4501, but has an appropriate size for playing, that will fit in your dioramas and has the looks and feel of a real Mos Eisley Cantina.
Well this could be a solution:
First, let me start by telling you that the Cantina Benches Pack is a setbuilder. Together with the Main Cantina Pack (the heart of the total of these Packs would be the Main Cantina Pack), the Cantina Entrance Pack and the Cantina Band Pack, it's going to be a complete cantina with a lot of figures and details.
The reason for dividing the Cantina in special packs is that the Mos Eisley Cantina only will be cool when all details are covered. So we need a band, an entrance with a droid detector, a bar, and of course some benches. But when you have all those things in one set, not only there's no way we can get all those minifigures in that one set, also it would certainly be smaller and less accurate.
The Cantina Benches Pack:
In this pack which fits to the Main Cantina Pack you will find Han Solo against Greedo in this small playset. Also in this set you'll have Chewbacca and two extra's: Hem Dazon and Ellors Madak. The head of Hem Dazon would be a new sculpt. All the mini-figures will be equipped with blasters of course. The build can be connected to the Main Cantina Pack, but is also as loose model nice and decorative.
In order to complete the whole cantina in all its details you will need all the Cantina Packs. This is only the Cantina Benches Pack. The other Cantina Packs you can find in my projects. Also there is a project of Star Wars Universe Packs which has also a Mos Eisley Cantina Universe Pack with extra mini-figures who will fit your Mos Eisley Cantina Really well.
I hope you will like this, brick on peoples!
Links to the other Cantinapacks:
Main Cantina
Cantina Entrance
Cantina Band
And a link to the Star Wars Universe Packs:
Star Wars Universe Packs


text:
Discussion in 'OT Bar' started by Basil McRae, Mar 16, 2010.
should I bet it?
lines courtesy of betus.com
i dont recall him being away from ot for 6 weeks.
Followed shortly after by a "hey check out my new tatoo" thread
followed by, "hey can i borrow some money thread"
"hey, i'm married and my wife is pregnant"
oh wait, wrong cage fuckup
Wait... How am I a fuck up?
I would consider the guy who is hated by his own fraternity, stalks a female cage member, stalks his ex, and horribly tried to make his own Loco Life style vblog alot more of a fuck up than the pro fighter who occasionally gets pissy about someone commenting on his 3rd grader designed tattoos
wait so you stalked a female cage member and made a horrible vblog to be like ryan loco?
you have shitty alan belcher style tats?
I'll take that line for anyone that wants to keep it in the family.
Say +2000.
Anyone want to bet with the TCMS house?
Ben you should bet
Are you fucking retarded?
right here is where you insinuated he was a fuckup.
LoL Colombian Necktie, the next Mythrel Shit I didn't have to teach you anything.
How are there betting lines for shit like this? What's to stop the TUF winner (or any number of people who know the results) from betting their life savings on themselves or something.
Most lines do not allow athletes to bet on their own team or themselves.
And plus its says that is going to win the whole show, no one knows who will win until the finale.
lol oh yeah that's right, forgot about that whole finale thing. I've been away from MMA for too long lols.
I'm like, shit why doesn't the winner tell his friend to bet 10,000 dollars on him or something??
If I knew who they were, I'd bet 11ty on each of the 2 finalists
I'm sure their odds are better than 2:1
ill bet on the jew


text: Okay I bought a bunch of fibers but, I'm not sure what to use to adhere them or even really how to use them. I have a photo tape from CM do you think that would work if I lay the tape on the page then adhere the fibers to the tape or is the tape to wide? Okay ladies what do you all use? And gentlemen I know we have a few of them. Any suggestions?


text:
Soften's Hair to prevent brittleness
Strengthens the Beard
Moisturises the Skin to prevent irritation
This Beard Oil is certified organic to COSMOS Organic standard - Using the highest quality ingredients in Europe.
Hand formulated in small batch from my base in Newcastle Upon Tyne, my organic unscented Beard Oil contains certified organic plant oils to provide excellent skin and hair moisturisation. Suitable for all skin types & beards - long and short. Because I only use pure oils the beard oil is quickly absorbed into the skin and hair and is non-greasy, and as it is organic, I do not use any chemicals, perfums, parbens or sulphates, the ingredients are 100% pure, 99.8% certified organic and 100% natural. - Designed for sensitive skin!
Directions For Use: Simply drop a few drops of beard oil onto your fingers and massage into a slightly damp beard, massage from the skin out to the tips of the beard and dab dry with a towel. For longer beards use a little more.
Results: Helps create a soft, moisturised & strong beard, and prevent beard irritation as the hair grows. Leaves a gentle forest aroma which lingers around 30-40 minutes before fading.


text:
Table of Contents
1. General Environment and Porter's Five Forces Model 3
1.1 General Environment 3
Politic 3
Economic 4
Socio cultural 5
Technological 6
1.2 Porter's Five Forces Model 7
Intensity of rivalry 7
Availability of Substitutes 8
Bargaining Power of Suppliers 9
Bargaining Power of Buyers 10
Threat of Entry 10
2. Resources, Capabilities, and Competencies 12
2.1 Resources 12
Marketing 12
Human Resources 13
2.2 Capabilities 14
Standard Operating System 14
Creative Advertising 15
Training System 15
2.3 Competencies 16
Quick Service 16
Value for Money 16
2.4 Growth Potential 16
3. McDonald's Strategy 17
3.1 SWOT Matrix 17
Strength: 17
Weakness: 18
Opportunity: 18
Threats: 18
4. Strategy Issues and Recommendation 20
4.1 Strategy Issues 20
4.2 Recommendation 20
1. General Environment and Porter's Five Forces Model
2.1 General Environment
Malaysia is a parliamentary democracy which is a constitutional monarchy with a prime minister as head of government. Malaysia uses multi-party system. Head of state of Malaysia is called Yang DiPertuan Agong. Yang DiPertuan Agong served for 5 years and was selected from nine sultans in the nine state take turns. As one of the former British colony, the system of government in Malaysia adopted the Westminster parliamentary system, the legacy of British colonial rulers. But in practice, the executive power is more inclined than in the legislative. There are three of the largest tribes in Malaysia that are Malay, Chinese, and India. Most of the Malaysians state government offices are almost occupied by ethnic Malays.
Trade regulations and policies are handling by the Ministry of International Trade and Industry (MITI). Ministry of International Trade and Industry is a ministry under the federal government of Malaysia. The ministry was given responsibility for overseeing...


text:
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text:
OCTIA Ltd 2017 will be held at
Edinburgh training & conference venue
16 ST Mary street
Edinburgh EH1 1SU
on Saturday April 1st 2017
For full details of how to get to the Edinburgh venue
Edinburgh is easy to reach through various forms of transportation
By car me take some time depending on where you live. The driving time from London is 7,5 hours so if you are coming from far you may want to look into the other options.
Good train services coming in to Edinburgh Waverley station. And the station is close to the venue.
Edinburgh airport is an internation airport just outside of the city. Trams operate between the airport and the city centre.


text:
Advice To Select The Right Car Covers
The car cover is the important one to secure the car from damage. The car cover gives an ideal and resists tearing for the car. The premium car covers from CARiD to retain its exquisite shine into the future. The Nissan Company has a wide range of car covers catering for both indoor and outdoor storage. The Outdoor car covers to protect the car from external factors like as atmospheric precipitation, windy conditions and give harmful UV rays of the sun. This company covers from are durable to use. This reflective cover gives the high water resistant coating for the car and it is used as the shield for the car. They are made from top class materials and will allow the moisture to trap the damage of cars. They will provide the multilayered to detect ripping and tearing of the fabric. A Car cover is also made from full-length fabrics to eliminate exasperating leakages. This cover is used to protect your car from any weather conditions such as snow, ice, high winds, etc. For the most reputable car covers come with a double seam to augment the main seam in prevention of leakages. Nissan Sentra car covers are waterproof and resistant to moisture, rotting and mildew.
The Silver guard is designed to be low-maintenance and inherently easy to keep clean. To keep your cover functioning optimally and your cover may need to be cleaned periodically. It detects the dirt and dust on either side of the cover can degrade its ability to repel moisture. The Sentra car covers are easy to clean and apply to the car. Install the cover on your vehicle in a mild and bio-degradable cleaner. The manufacturers of this company provide good quality for the products. Hose it down again and hang to air dry. This cover id guarantees to fir your car perfectly. To clean the inside of the car easily and install the cover inside-out. Keeping your cover clean will ensure years of optimal protection. The elastic lining will be fitted on the front of the cover for adjusting the cover. It has two buckles and straps are attached to the cover in the front and other extra fit are attached in the back. The warranty protects you against any defects such as soiling, fading, disintegration, stains, rips and normal use of the cover. A Car cover is made to last a very long time. If for any reason the cover fails and they will send you a free replacement.
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Road tractors- on how it is changing in its way of servicing
Commercial vehicles and the tractors are also in need of supplies like all other types of vehicles in the market. Every kind of vehicle for the construction of roads and
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text:
"Programming is an art form that fights back."
Tag Archive: Programming
"Programming is 10% science, 25% ingenuity and 65% getting the ingenuity to work with the science."
– Unknown
"Programming graphics in X is like finding sqrt(pi) using Roman numerals."
– Henry Spencer
- Any given program, when running, is obsolete.
- Any given program costs more and takes longer.
- If a program is useful, it will have to be changed.
- If a program is useless, it will have to be documented.
- Any program will expand to fill available memory.
- The value of a program is proportional to the weight of its output.
- Program complexity grows until it exceeds the capabilities of the programmer who must maintain it.
- Any non-trivial program contains at least one bug.
- Undetectable errors are infinite in variety, in contrast to detectable errors, which by definition are limited.
- Adding manpower to a late software project makes it later.
And that is all I have to paste about that…
Impossible Code
To code the impossible code
To bring up a virgin machine
To pop out of endless recursion
To grok what appears on the screen
To right the unrightable bug
To endlessly twiddle and thrash
To mount the unmountable magtape
To stop the unstoppable crash
This is my quest
To debug that code
No matter how hopeless
No matter the load
To write those routines
Without question or pause
To be willing to hack FORTRAN IV
For a heavenly cause
And I know if I'll only be true
To this glorious quest
That my code will run cuspy and calm
When it's put to the test
And the queue will be better for this
That one man, scorned and destined to lose
Still strove with his last allocation
To scrap the unscrappable kludge
Sung like so: http://www.youtube.com/watch?v=RfHnzYEHAow
I couldn't find a recording of the Impossible Code, which is a pity, I'd probably pay money for it.
There are three kinds of lies: Lies, damned lies, and benchmarks.
While going through some of my old backups I found a document from 2001 with the following text (its amusing and I don't know who wrote it):
There are so many programming languages available that it can be very difficult to get to know them all well enough to pick the right one
for you. On the other hand most men know what kind of woman appeals to them. So here is a handy guide for many of the popular programming
languages that describes what kind of women they would be if programming languages were women.
Assembler A female track star who holds all the world speed records.
She is hard and bumpy, and so is not that pleasant to embrace. She can cook up any meal, but needs a complete and detailed recipe. She is not
beautiful or educated, and speaks in monosyllables like "MOV, JUMP, INC". She has a fierce and violent temper that make her the choice of
last resort.
FORTRAN Your grey-haired grandmother.
People make fun of her just because she is old, but if you take the time to listen, you can learn from her experiences and her mistakes. During
her lifetime she has acquired many useful skills in sewing and cooking (subroutine libraries) that no younger women can match, so be thankful
she is still around. She has a notoriously bad temper and when angered will start yelling and throwing dishes. It was mostly her bad temper
that made granddad search for another wife.
COBOL A plump secretary.
She talks far too much, and most of what she says can be ignored. She works hard and long hours, but can't handle really complicated jobs.
She has a short and unpredictable temper, so no one really likes working with her. She can cook meals for a huge family, but only knows bland
BASIC The horny divorcee that lives next door.
Her specialty is seducing young boys and it seems she is always readily available for them. She teaches them many amazing things, or at least
they seem amazing because it is their first experience. She is not that young herself, but because she was their first lover the boys always
remember her fondly. Her cooking and sewing skills are mediocre, but largely irrelevant, it's the frolicking that the boys like.
The opinion that adults have of Mrs. BASIC is varied. Shockingly, some fathers actually introduce their own sons to this immoral woman! But
generally the more righteous adults try to correct the badly influenced young men by introducing them to well-behaved women like Miss Pascal.
PL/I A bordello madam.
She wears silk dresses, diamonds, furs and red high heels. At one time she seemed very attractive, but now she just seems overweight and tacky.
Tastes change.
C A lady executive.
An avid jogger, very healthy, and not too talkative. Is a good cook if you like spicy food. Unless you double-check everything you say
(through LINT) you can unleash her fierce temper. Here daughter C++ is still quite young and prone to tantrums, but it seems that she will grow
up into a fine young woman of milder temper and more sophisticated character.
ALGOL 60 Your father's wartime sweetheart, petite, well proportioned, and
She disappeared mysteriously during the war, but your dad still talks about her shapely form and their steamy romance. He never actually tasted much of her cooking, but they did exchange simple recipes by
Pascal A grammar school teacher, and Algol 60's younger sister.
Like her sister she is petite and attractive, but very bossy. She is a good cook but only if the recipe requires no more than one pot (module).
Modula II A high-school teacher and Pascal's daughter.
Very much like her mother, but she has learned to cook with more than one pot.
ALGOL 68 Algol 60's niece.
A high-society woman, well-educated and terse. Few men can fully understand her when she talks, and her former lovers still discuss her
mysterious personality. She is very choosy about her romances and won't take just any man as her lover. She hasn't been seen lately, and rumor
has it that she died in a fall from an ivory tower.
LISP She is an aging beatnik, who lives in a rural commune with her
hippie cousins SMALLTALK and FORTH.
Many men (mostly college students) who have visited the farmhouse, enthusiastically praise the natural food, and perpetual love-ins that
take place there. Others criticize the long cooking times, and the abnormal sexual postures (prefix and postfix). Although these women
seldom have full-time jobs, when they do work, their employers praise them for their imagination, but usually not for their efficiency.
APL A fancy caterer specializing in Greek food.
She can cook delicious meals for rows and rows of tables with dozens of people at each table. She doesn't talk much, as that would just slow
her work down. Few people can understand her recipes, since they are in a foreign language, and are all recorded in mirror writing.
LOGO A grade-school art teacher.
She is just the kind of teacher that you wish you had when you were young. She is shapely and patient, but not an interesting
conversationalist. She can cook up delicious kiddie snacks, but not full-course meals.
LUCID & PROLOG These clever teenagers show a new kind of cooking skill.
They can cook up fine meals without the use of recipes, working solely from a description of the desired meal (declarative cooking). Many men
are fascinated by this and have already proposed marriage. Others complain that the girls work very slowly, and that often the description
of the meal must be just as long as a recipe would be. It is hard to predict what these girls will be like when they are fully mature.
Ada A WAC colonel built like an Amazon.
She is always setting strict rules, but if you follow them, she keeps her temper. She is quite talkative, always spouting army regulations,
and using obscure military talk. You gotta love her though, because the army says so.
"As soon as we started programming, we found to our surprise that it wasn't as easy to get programs right as we had thought. Debugging had to be discovered. I can remember the exact instant when I realized that a large part of my life from then on was going to be spent in finding mistakes in my own programs."
– Maurice Wilkes discovers debugging, 1949
"Programming is like sex: one mistake and you're providing support for a lifetime."
– Michael Sinz