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Labor statistics point to an increase in sales as a key occupation in the present and future workforce. In his recent book, To Sell is Human, Daniel Pink points out the number of sales people in the United States outnumbers the entire federal government workforce by five to one.
And it came down to three.
Each with 15 final minutes to lay claim to Bloomsburg University's second annual BU/UPS Sales Competition that featured 18 student competitors, including representatives from Kings College and Wilkes University.
The day — organized and managed by Monica J. Favia, coordinator of Zeigler College of Business professional sales program — started with a competition round where each student had 15 minutes to present and close. Three finalists were chosen, who then had another 15 minutes for their final presentations with the same judging criteria.
Josh Salak, a senior business administration marketing and finance major, won the competition. Fellow finalists were runner-up Alison DiClemente, a senior business administration marketing major, and third place finisher Chris Mekosh, a senior communication studies major pursuing minors in economics and marketing.
In the competition students were judged on their professional sales ability to:
Judges, who were all industry professionals, also looked at the students' communication skills and overall performance. The winner received an iPad Pro and custom Tom James suit. Second place received a Go Pro, while third place took home a phone projector. The competition also featured a career fair featuring UPS, Sprint, Quadrant EPP USA, CED, Gartner, ADP and Tom James.


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Climate Of Change (2010)
Tilda Swinton narrates this documentary about ordinary people across the globe whose dedication to fighting the devastating effects of global warming helps prove that everyday citizens have the capacity to enact monumental change.
Directed By: Brian Hill
Rated: Unrated
Running Time:
Genre: Documentary, Special Interest
Release Date: December 31, 2010
DVD Release Date: February 22, 2011
Rotten Tomatoes Critic Reviews
Daniel M. Gold
New York Times
Credited to four directors of photography, the movie is never less than stunning.
More reviews for Climate Of Change

subset: commoncrawl


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Santa Barbara, CA (PressExposure) June 03, 2009 -- The next LSAT administration date is June 8, 2009, and with a reported 11.5% increase in the number of LSATs taken in February, law school admission experts are predicting a surge of applicants in the Fall.
According to law school admission consultant [http://www.lawschoolexpertbook.com/ann_levine.html] Ann Levine, due to the economic downturn and lack of job prospects for recent college graduates, 2010 promises to be one of the most competitive years for law school admission in recent history.
Levine, author of The Law School Admission Game: Play Like an Expert. recently teamed up with four prominent LSAT strategists to share âLast Minute Tips for LSAT Takers [http://www.lawschoolexpert.com/blog/2009/06/01/the-best-45-minutes-youll-spend-before-the-lsat/]â including: > How to know if youâre ready for the test. > How the Law School Admission Councilâs (LSAC) new policy about changing test dates impacts test takers and their decisions about whether to take the June LSAT or wait for the September LSAT date. > How to know whether to cancel an LSAT score after taking the test.
LSAT experts from across the country, including Josh Morrison of LogicProLSAT.com, Donald Viscardi of Inspirica.com, Bara Sapir of TestPrepNY.com, and Paul Siemons of AdvantageTesting.com, participated in the 45-minute program on BlogTalkRadio to offer concrete tips for preparing for the LSAT in the week before the exam.
âWhen deciding whether or not to take the June LSAT, remember that LSACâs new policy about changing test dates means that changing your test date after the May 17, 2009 deadline will count as a cancelled score and therefore as one of the three times you can take the test in two years,â Levine said. âIf itâs going to be a cancelled score anyway, law school applicants might as well take the exam and cancel it after to gain the experience of testing conditions for next time.â
For more concrete tips and LSAT test preparation strategies for law school applicants the week before the LSAT, listen to the program here: [http://tinyurl.com/JuneLSAT]
âWhether this is your first time taking the LSAT or you would like to increase your score, these tips for the week before the test apply to you,â Levine said. âAs law school admissions become even more competitive, the LSAT is the most important factor that is still within your control. You will need to take advantage of proven strategies that can help you be more competitive when applying to law school.â
About Ann Levine Known as âthe secret weapon of law school applicants nationwide,â Ann Levine is a prominent and a former director of admissions for two ABA law schools. Since founding Law School Expert in 2004, she has helped thousands of applicants nationwide achieve their admission goals. Her recently released law school admission guide provides timely and relevant advice to law school hopefuls, including guidance on the application process, selecting schools, crafting compelling personal statements, as well as dependable financial aid and LSAT advice.
For more information about The Law School Admission Game: Play Like an Expert, please visit http://www.lawschoolexpertbook.com/


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The Route Back 2 Hiphop: Presents " They Call me K-SOLOPosted by on in TV
The Route Back 2 Hiphop: Presents " They Call me K-SOLO a docu-series exploring his first album " Tell the world my name". The K-SOLO story is a unique one in itself. While most of the famed " Hit Squad" assemble by Erick Sermon and Parrish Smith in the late 80's better know as EPMD. The were one of the most successful Groups to put together a group of new artist that all went either platinum or Gold in sales. Which at that time was unheard of. But with success comes , Jealousy. and envy and Break ups. The Call me K-Solo is the story about his time with Hit Squad, The East Coast West coast Beef, Signing to Death Row records, and his time as one of the most respected lyricist. K-Solo created that rhyme and spelling word style that got him major attention. But as DMX rose to fame there was a rumor that K-solo had stole that style from DMX in Jail. The story is told by no other than Kevin Madison himself as well as his younger brother.
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The University of Exeter offers a number of programmes in Psychoanalytic Psychotherapy leading to postgraduate degree level qualification and/or professional clinical qualification.
1) Psychotherapy clinicians who have completed, or are in the process of psychoanalytic psychotherapy training in which the academic component is equivalent to a Masters degree level.
This includes international applicants.
2) Students who have completed the MSc degree at the University of Exeter, are undertaking the Professional Qualifying Training and wish to combine this with the DClinPrac.
For students undertaking the Qualifying Training, this runs in tandem with the clinical programme. During the first two years, students participate in a taught programme, usually two five day block events each year.
In addition, they are members of a research group and receive intensive tutorial and supervisory input, which equips members with the relevant research skills, complementary to their clinical training.
Please contact: Katrina Shannan
Tel: +44 (0)1392 725753
Email: firstname.lastname@example.com


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Load the Open Source Homebrew Pong demo to the Papilio Arcade Hardware. The provided bit file includes the ROMs for the Pong demo pre-synthesized in.
Load your MAME compatible ROMs in seconds. Use the Papilio Arcade Blaster app to manage and load MAME compatbile ROMs to the Papilio Arcade hardware.
Learn how to load the ZPUino Soft Processor with integrated VGA controller so you can write homebrew games in the Arduino IDE. Walks you through loading the bit file, compiling the C source code, and loading the result to the Papilio Arcade.
This guide shows you how to synthesize the source code for the Pac-Man hardware type. Synthesizing the project lets you include your own ROMs or make customizations to the hardware such as dip switch settings. This guide targets Pac-Man but is applicable to all hardware types.
Take a look at the VGALiquidCrystal library to see other cool things you can do with the ZPUino. The VGALiquidCrystal library allows you to convert Arduino LCD code to run on a VGA monitor by changing one line of code.


text: News 355-HP Volkswagen GTI Black Dynamic Premieres at Worthersee Festival Erick Ayapana writerMay 18, 2012 Erick Ayapana writerMay 18, 2012 Share this article in: Facebook Twitter Google Plus Email Free Price Quote From a Local Dealer View Special Offers No Obligation, Fast & Simple Free New Car Quote Change Car Select Make Acura Alfa Romeo Aston Martin Audi Bentley BMW Buick Cadillac Chevrolet Chrysler Dodge Ferrari FIAT Ford Genesis GMC Honda Hyundai Infiniti Jaguar Jeep Karma Kia Lamborghini Land Rover Lexus Lincoln Lotus Maserati Mazda McLaren Mercedes-Benz MINI Mitsubishi Nissan Porsche Ram Rolls-Royce Scion smart Subaru Tesla Toyota Volkswagen Volvo Select Model Atlas Beetle Cabriolet CC e-Golf Eos EuroVan GLI Golf Golf Alltrack Golf III GTI Jetta Jetta Hybrid Jetta III Jetta SportWagen Passat Phaeton R32 Rabbit Routan Tiguan Touareg Touareg 2 Touareg Hybrid Touareg TDI GO 1. Vehicle Option Trim Exterior Color No Preference Black Blue Brown Gold Green Orange Red Silver White Yellow Interior Color No Preference Beige Black Blue Gray Green Other Red White Buying Time Frame Within 48 hours Within a week Within two weeks Within a month More than a month Payment Method Undecided Loan Lease Cash Trade In? Yes No 2. Contact Info First Name Last Name Address City State -- AL AK AZ AR CA CO CT DE DC FL GA HI ID IL IN IA KS KY LA ME MD MA MI MN MS MO MT NE NV NH NJ NM NY NC ND OH OK OR PA RI SC SD TN TX UT VT VA WA WV WI WY Zip Code Phone Email 3. Dealer Selection Receive your free dealer pricing information by completing your contact information! It's time again for the annual Worthersee Festival where Volkswagen shows off wild concepts and modified cars for wide-eyed VW fanatics. This year it's the Volkswagen GTI Black Dynamic, a customized hatch with 355 hp and an 1800-watt sound system.VW says nine apprentices between the ages of 18 and 23, dubbed mechatronics technicians, performed the modifications. The technicians massaged the engine and gearbox management system to churn out the extra bump in power, which is 148 horsepower more than stock. Other mechanical upgrades include an oversized exhaust setup, a sport suspension (1.38 inches lower than stock), and an eight-piston brake system with red calipers.As the GTI Black's name implies, the exterior is finished in metallic black paint, with flat anthracite film trim, while the interior is finished with a two-tone, black and red color scheme. Technicians also added black Alcantara roof lining and stamped GTI lettering on the doors. Not only did the future techs tinker under the hood, but they also added some punch in the cargo area. There, a sound system sits beneath see-through plexiglass and produces an eardrum shattering 1800-watts of power."For our team, the GTI Black Dynamic is the high point of our training," said future mechatronics technician Martin Schmidt. "The amount that we have learned is incredible, and we have developed our own ideas and implemented them in 'our' car. Where else do you get an opportunity like that?"In sharp contrast to the GTI Black Dynamic is the GTI ConceptWhite. This concept car sports Oryx White matte paint, while the interior features black Nappa leather seats with red contrast stitching.Also making an appearance is the GTI Cabriolet, which appeared at last year's festival in concept form. The GTI drop-top officially debuted at this year's Geneva motor show and Volkswagen still hasn't committed to any U.S. plans. Finally, Volkswagen also showed off the Polo R WRC street and race-ready variants. The latter produces almost 300 hp, accelerates from 0-62 mph in a claimed 4.1 seconds, and is a prototype for the FIA World Rally Championship.Source: Volkswagen Share this article in: Facebook Twitter Google Plus Email 355-HP Volkswagen GTI Black Dynamic Premieres at Worthersee Festival /9 Advertisement to Skip 1 | 9 2 | 9 3 | 9 4 | 9 5 | 9 6 | 9 7 | 9 8 | 9 9 | 9


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Dear All, We are pleased to officially report to you the the Newly Elected Officers and Directors for the Kwa-Zulu Natal Free State Conference 2016 – 2018: EXECUTIVE OFFICERS PRESIDENT Lincoln de Waal EXECUTIVE SECRETARY Phumlani Majola CHIEF FINANCE OFFICER Hermie Munez DEPARTMENTAL DIRECTORS ASSISTANT TREASURER […]
Some Photos of the KNFC Session
[Show slideshow]
New KNFC President Chosen
The new Kwazulu Natal Free-state Conference president has been chosen. He is Pastor Lincoln De Waal of the Universitas church in Bloemfontein. (Photo courtesy of SAU Communication Dep)
The Southern Africa Union Conference Resolution on Woman's Ordination
WHEREAS a Pastoral Consultative Meeting for administrators and pastors with the Southern Africa Union Conference was held at SAU Headquarters, Bloemfontein on August 4-5, 2015 to consider the actions taken at the 2015 GC Session held at San Antonio Texas with specific focus on: The revisions made to the 28 Fundamental Beliefs; The revisions made […]
New Website
Good Day Everyone, Please be patient with us while we update our website. Thank you and please watch this space for more details. Thank you


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Busty teacher Kendra Lust seducing her student by showing him her huge juicy tits
Duration: 3min 00sec Views: 15 154 Submitted: 5 years ago Submitted by:
Description: Gorgeous brunette Kendra Lust gets called into her boss's office to get scolded for her distracting outfits. Instead of taking a lesson, she doubles down by whipping her tits out and strokes her pussy through black panties before chugging on his big dick.
Channel: Naughty America
Pornstars: Kendra Lust


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School of Earth and Environment
Prof Steve Hencher
Emeritus Professor in Engineering Geology
Email address: firstname.lastname@example.com
Affiliation: Institute of Applied Geoscience
Research Interests
- Landslide mechanisms in weathered terrain.
- Shear strength of rock joints and rock masses
- Ground investigation techniques and rock classification.
- Litigation in Civil Engineering and how to avoid it.
Teaching Interests
Part time teaching to MSc students at Leeds and at Hong Kong University.
- Hencher SR; Richards LR (2014) Assessing the Shear Strength of Rock Discontinuities at Laboratory and Field Scales, Rock Mechanics and Rock Engineering, . doi: 10.1007/s00603-014-0633-6
- Hencher SR (2014) Characterizing discontinuities in naturally fractured outcrop analogues and rock core: The need to consider fracture development over geological time, Geological Society Special Publication, 374, pp.113-123. doi: 10.1144/SP374.15
- Lee SG; Hencher SR (2013) Assessing the stability of a geologically complex slope where strong dykes locally act as reinforcement, Global View of Engineering Geology and the Environment - Proceedings of the International Symposium and 9th Asian Regional Conference of IAEG, pp.117-121.
- Lee SG; Hencher SR (2013) Assessing the stability of a geologically complex slope where strong dykes locally act as reinforcement, Rock Mechanics and Rock Engineering, 46, pp.1339-1351. doi: 10.1007/s00603-013-0372-0
- (2012) Practical Engineering Geology, CRC PressI Llc.
- Hencher SR (2012) Discussion of Alejano, Gonzalez and Muralha (2012), Rock Mechanics and Rock Engineering, pp.1-3. doi: 10.1007/s00603-012-0288-0
- Hencher SR; Lee SG; Carter TG; Richards LR (2011) Sheeting joints - Characterisation, Shear Strength and Engineering, Rock Mechanics and Rock Engineering, 44, pp.1-22.
- Hencher SR (2010) Preferential flow paths through soil and rock and their association with landslides, HYDROL PROCESS, 24, pp.1610-1630. doi: 10.1002/hyp.7721
- Hencher SR; Lee SG (2010) Landslide Mechanisms in Hong Kong, Engineering Geology Special Publications, 23, pp.77-103.
- Devonald DM; Thompson JA; Hencher SR; Sun HW (2009) Geomorphological landslide models for hazard assessment: a case study at Cloudy Hill, Hong Kong, Q J ENG GEOL HYDROGE, 42, pp.473-486. doi: 10.1144/1470-9236/08-001
- Lee SG; Hencher SR (2009) The repeated failure of a cut-slope despite continuous reassessment and remedial works, ENG GEOL, 107, pp.16-41. doi: 10.1016/j.enggeo.2009.03.011
- Shaquour F; Jarrar G; Hencher S; Kuisi M (2008) Geotechnical and mineralogical characteristics of marl deposits in Jordan, Volume 55, . doi: 10.1007/s00254-007-1128-5
- Hencher SR (2008) Slide Rule Technology, 41, pp.19-21.
- Hencher SR (2008) The 'New' British and European Standard Guidance on Rock Description, Ground Engineering, 41, pp.17-21.
- Hencher SR (2007) Slope Failures in Hong Kong, Geophysical Research Abstracts, 9, .
- Blake JR; Renaud JP; Anderson MG; Hencher SR (2003) Prediction of rainfall-induced transient water pressure head behind a retaining wall using a high-resolution finite element model, COMPUT GEOTECH, 30, pp.431-442. doi: 10.1016/S0266-352X(03)00055-7
- Hencher SR; Liao QH; Monaghan BG (1996) Modelling slope behaviour for open-pits, Transactions of the Institution of Mining and Metallurgy. Section A: Mining Industry, pp.37-47.
- Nettleton I; Martin S; Hencher S; Moore R () Debris Flow types and Mechanisms. In Scottish Road Network Landslide Study, pp.45-67.
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Pankaj SharmaShowing profile of Pankaj Sharma. Subscribe to author's feed to follow recent articles!
Pankaj Sharma has 1 articles and online since 21.12.2011.
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RF planing and Optimization
Published on December 26th 2011 | Career
Published on December 26th 2011 | Career
Radio frequency are comes under the Electronics and Electrical engineering ,It mainly deals with Radio Frequency and also Radio Frequency equipment. It deals with equipment that are designed to ...


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Part no 95-073 and 95-201
A quick learner from Okemos, MI (48864) says:
May 9, 2015
You web site implies one is the mating part to the other (ie pins go on top corner and 52-201 goes on bottom corner. Dimensions on each are different on the leg, 95-201 is 5/16" and 95-073 is 3/16". The 95-201 is the correct dimension for my application but the 95-073 may not fit tight enough. Do you have another part number that matches the 95-201 better?
Dave Sr. from SWISCO responded:
May 11, 2015


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Author and filmmaker Catherine Breillat has gained a reputation as one of the most controversial women in contemporary arts, often focusing on the erotic and emotional lives of young women, as told from the woman's perspective.
This month World Movies celebrates International Women's Day with two of Breillat's captivating films, An Old Mistress and Romance.
An Old Mistress (France, 2007)– Thursday 8 March 9.30pm
A handsome young man vows to stay away from his long term mistress, in this intimate chamber piece full of betrayals, confidences and secrets. Nominated for a Palme d'Or at 2007 Cannes International Film Festival.
Romance (France, 1999) – Thursday 8 March 11.25pm
Initially refused classification in Australia, the notorious film about a women testing her sexual boundaries in her search for intimacy and fulfilment. An intelligent and disturbing film by Catherine Breillat.


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All reviews seem negative
i ask about 12 times to fallow a mail recuest never b.taking care ...pembroke pines mail service 0 points at 115 nw 119 av .camden portofino
Pros: wors service
Nationwide courier service specializes in first-class certified mail delivery, domestic mail, signature confirmations, passport processing and postage stamps.
From family friendly trips with kid friendly activities to local plumbers lawyers, spas, and contractors. Judy's Book has millions of listings and reviews for the best and not so great. Whether you're looking for a specific business or just trying to discover great places we make it easy. We're a family oriented site focusing on bringing trusted reviews and recommendations to moms and others. Green and Sustainable places are becoming more relevant to Judy's Book users, have a favorite place? Write a review and tell users why it's Green!


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A brilliant album – and real turning point for Herbie Hancock! After first coming onto the scene as the soul jazz hero between Blue Note funky classics like "Watermelon Man" or "Blind Man, Blind Man" – Herbie emerges here as a concerned modernist with a strand of spirituality that runs deeper than previously expressed. The key track in this vision is his brilliant modal number "Maiden Voyage" – one of those tunes that sounded totally fresh immediately, and which was picked up by many others as a jazz anthem during the 60s. The rest of the album's equally great – and features George Coleman on tenor, Freddie Hubbard on trumpet, Ron Carter on bass, and Tony Williams on drums – all making for a very hip lineup that really lets Herbie open up stylistically! Other titles include "Dolphin Dance", "Little One", and an original version of "Survival Of The Fittest". (70s pressing. Cover has wear, marker in one corner & a split top seam.) © 1996-2017, Dusty Groove, Inc.
We realize that there are many different interpretations of the standard grades used for pre-owned vinyl record albums & CD, so we thought we'd offer you the ones that we are working with, so you have an idea what we mean when we give the grade for a non-new item on our pages.
Below are stated conditions for a used vinyl records at Dusty Groove. Grading for the cover should be assumed to be near (within a "+" or "-") the grading for the vinyl. If there is significant divergence from the condition of the vinyl, or specific flaws, these will be noted in the comments section of the item. However, please be aware that since the emphasis of this site is towards the music listener, our main concern is with the vinyl of any used item we sell. Additionally, please note that all of our records are graded visually; considering the volume of used vinyl we handle, it is impossible for us to listen to each record. If we spot any significant flaws, we make every attempt to listen through them and note how they play.
The following grading conditions apply to the vinyl component of an album or single:
If something is noteworthy, we try to note it in the comments — especially if it is an oddity that is the only wrong thing about the record. This might include, but isn't limited to, warped records, tracks that skip, cover damage or wear as noted above, or strictly cosmetic flaws.


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TOMORROW, FUKUSHIMA will be a THOUSANDFOLD GREAT RISK FOR LIFE.
There is the DANGER of COLLAPSE of REACTOR 4 ; the BUILDING is WEAKENED BY THOUSAND RADIOACTIVITY.
TOMORROW, MEN WILL EXPERIENCE a THOUSANDFOLD GREAT NUCLEAR DISASTER.
MEN are GREAT IGNORANTS of this EXTREME DANGER.
DESTRUCTION WILL START WELL AHEAD OF DISMANTLEMENT of USED COMBUSTION RODS.
FUKUSHIMA is experiencing ENORMOUS LEAKING of RADIOACTIVE WATER DUE TO PIERCING of STORAGE TANKS. TOMORROW, GROUND WATER will be THOUSANDFOLD CONTAMINATED.
WE are VERY MUCH WORRIED about MEN'S HEALTH. THOUSAND WORDS have been USELESS. DOING AS IF FUKUSHIMA being FINISHED, is a GREAT ERROR of MEN.
TOMORROW, the COMMUNICATION of the DIVINE ABC will be CONSIDERED TRUE.
TOMORROW, MEN WILL AT LAST UNDERSTAND the DIVINE ADVICE to EVACUATE COMPLETELY the ZONE of FUKUSHIMA RIGHT FROM the BEGINNING.
The MISTAKE of the GOVERNMENT is : HAVING IGNORED DIVINE ADVICE.
A WOMAN MESSENGER has TRANSMITTED THOUSAND WORDS to the GOVERNMENT in order TO PROTECT the POPULATION. It is an ERROR HAVING CONSIDERED the Divine ABC AS INVENTED. This WOMAN IS IN CHARGE of the TRANSMISSION of the DIVINE ABC to MEN in GOVERNMENT. This WOMAN HAS an EXCEPTIONAL ABILITY TO COMMUNICATE WITH SOULS. This WOMAN IS MY MESSENGER. This WOMAN IS EXCEPTIONALLY GIFTED in RADESTHESIA, IDEAL FOR the COMMUNICATION of DIVINE ABC. Her GREAT ABILITY of CONCENTRATION ENABLES DIRECT COMMUNICATION WITH SOUL ST JESUS. This EXCEPTIONAL COMMUNICATION IS a GREAT PATH OF COMMUNICATION FOR SOUL ST JESUS. This WOMAN IS DILIGENT IN TRANSMITTING THOUSAND ABC IN ENGLISH FOR EASIER COMPREHENSION of DICTATIONS made in FRENCH. This WOMEN SHOULD BE CONSIDERED MY MESSENGER. TRUST IN DIVINE ABC WILL AVOID THOUSAND SUFFERING OF the POPULATION.
POPULATION WILL SUFFER THOUSANDFOLD GIVEN the INCREDULITY of MEN in GOVERNMENT.
ST JESUS SENDS THOUSAND WORDS in order TO AVOID THOUSAND SUFFERING of the POPULATION, BUT his WORDS ARE NOT BELIEVED IN. ST JESUS WANTS the POPULATION BEING PROTECTED by its GOVERNMENT.
TO TRUST in DIVINE ABC REQUIRES THOUSAND FAITH. LACK of FAITH WILL LEAD TO SUFFERING.
TOMORROW, INCREDULITY will be CONSIDERED a GREAT ERROR of MEN in GOVERNMENT, BUT IT WILL BE TOO LATE TO AVOID THOUSAND SUFFERING OF the POPULATION.
TOMORROW, MEN in GOVERNMENT will be CONSIDERED the GREAT CULPRITS.
TOMORROW, MEN WILL BELIEVE IN DIVINE WORDS. Men's GREAT FAITH WILL BE THE BEGINNING of a NEW ERA FOR MEN. TOMORROW, MEN WILL BELIEVE IN DIVINE ADVICE. FUKUSHIMA WILL CHANGE THOUSANDFOLD MEN'S ATTITUDE. TOMORROW, MEN WILL GET TO KNOW ANOTHER WAY OF LIFE.
THOUSAND ADVICE FOR a BETTER LIFE will be THOUSANDFOLD FOLLOWED.
The GREAT ERROR will be UNDERSTOOD BY MEN in GOVERNMENT.
MEN AT LAST will be ELEVATED THOUSANDFOLD SPIRITUALLY.
TOMORROW, FUKUSHIMA will be CONSIDERED a GREAT DIVINE TEACHING.
MAN will have UNDERSTOOD THAT IT IS NOT HE THE MASTER OF THE WORLD, BUT that IT IS GOD WHO IS THE MASTER OF THE WORLD.
(Divine Message received September 26 - 27, 2013)
Japanese are already suffering from radiation exposure. More on ENENEWS
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Status: Open
Know more about this business than we do? Cool! Please submit any corrections or missing details you may have.Help us make it right
Authentic is the word we want you to know about us! We have 15+ years of experience in the restaurant business and we always look for new ways to improve our menu items to satisfy your cravings for authentic Mexican food!
Be the first MLive.com user to add photos or videos of Tacos El Ganadero
One visit was enough for me, after watching the cook grab a (literal) handful (bare-handed, no glove) of rice and throw it on a plate. Noticed that the grill cook was touching the food also... Don't know where their hands have been, but no E. coli, listeria, salmonella or botulism for me! Keep this in mind when you eat there...!!
Great little Mexican restaurant. Do not overlook this place. It starts out with excellent chips and salsa. Mix the red and green salsa for the best flavor. The wet burrito and cheese enchiladas are our typical choice, which are delicious. Other friends and family have tried other items and enjoyed them all. It does not serve alcohol, which is the...
Tacos El Ganadero can be found at Bridge St Nw 950. The following is offered: Restaurants: Mexican. The entry is present with us since Sep 9, 2010 and was last updated on Nov 14, 2013. In Grand Rapids there are 18 other Restaurants: Mexican. An overview can be found here.
Tacos El Ganadero is located at 950 Bridge St NW, Grand Rapids, MI. This location is in the SWAN neighborhood. This business specializes in Mexican Restaurants and has 1 review(s) with a star rating of 5.0. Tacos El Ganadero is open Mon. - Sun. 10am - 10pm and accepts Visa.


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No keywords found. Consider adding keyword meta entry for ranking your site higher!
Google Safe Browsing - Safe website. Clean from Viruses, Malicious Worms, Adwares, Trojans, Spywares and Suspicious Phishing Attacks.


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During Tuesday's presidential news conference, Jonathan Karl of ABC News asked the president if he still had "the juice" to get the rest of his agenda through Congress.
The president responded jokingly.
It was a funny exchange, but also a telling one, less about this president's ability to maneuver and push policy than about media organizations that are forever looking beyond the moment, so much so that they do little justice to — and demonstrate a marvelous vacuity about — the present.
Too many people want to skip — or write off — the second term of this presidency and begin covering the contenders for the next one.


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Medical Staff
Walter Rios Corujo, MD
Teddi Thornhill, MD
Pediatric Urgent Care offers complete children's health services. Our outpatient office is designed to serve you and your child's healthcare needs in a friendly, comfortable setting. We provide the best medical care to every child every day. A team of highly qualified health care professionals and the staff at Pediatric Urgent Care are there when you need them.
We are a Patient Centered Medical Home
Patient Centered is a way of saying that the patient is the most important person in our healthcare system.
A Medical Home is an approach to providing total health care. With your medical home, you will join a team that includes health care professionals, trusted friends or family members (if you wish), and most importantly – you.
Your responsibility as a Patient is to provide your PCMH team a complete Medical History and information about care you have obtained outside.


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Hide Images
1Heat oven to 400ºF. Grease bottoms only of 24 small muffin cups, 1 3/4x1 inch, or line with paper baking cups.
2In large bowl, beat milk, oil, juice concentrate, orange peel, almond extract and egg with spoon until blended. Stir in flour, granulated sugar, baking powder and salt all at once just until flour is moistened (batter will be lumpy). Stir in 1/3 cup almonds. Divide batter evenly among cups. Sprinkle with sugar crystals and 2 tablespoons almonds.
3Bake muffins 10 to 15 minutes or until light golden brown. Immediately remove from pan to wire rack.


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The most important things at a glance
|New / used:
|Year built:
|2x Mercruiser (700 PS )
|9,14 m (30,0 ft.)
|3,35 m (11,0 ft.)
|Anchored at:
|Niceville, FL
Full list of details about this ad
|No detail information available, please contact the dealer to find out more about this listing.
Description & specificationsEnglish description
This is a straightforward reliable and well built express cruiser with twin inboard power and a flush deck cockpit. Her wide beam provides a spacious interior with berths for four. Starboard engine was completely overhauled October 2011. The entire cabin has been refurbished with New cushions; New headliner; bulkheads; new carpet and all wood reoiled. The extended part of the bimini is new with stainless steel frame. There is a new bowsprit and the teak grates on the dive platform are new.
Flag of Registry United States
Hull Shape Deep Vee
LOA 31 ft 4 in
Beam 11 ft 0 in
Minimum Draft 2 ft 5 in
Headroom 6 ft 3 in
Dry Weight 9500 lbs
Engine Brand Mercruiser
Engine(s) Total Power 700 HP
Engine Model 5.7L
Engine Type Inboard
Drive Type Stern drive
Propeller 3 blade propeller
Cruising Speed 28 knots
Maximum Speed 32 knots
Year Built 1988
Fresh Water Tanks (40 Gallons)
Fuel Tanks (200 Gallons)
Number of double berths 2
Number of heads 1
Electrical Circuit 110V
Electric windlass
Forward in the salon is the offset 8 long by 53 wide (at widest point) master berth. There is a teak lined 12 X 27 mirrored cabinet at the foot of the berth to starboard. Lots of storage beneath the berth. Above the berth is an 18 X 19 hatch for ventilation and light.? Aft to port is the dinette with bench seating. The table is 41 X 27 and when lowered it makaes into a 63 long by 44 wide berth.? Storage is under both bench seats. The electric panel is located above the aft bench seat. (2) 11 X 11 light/ventilation hatches are above the salon.
Electronics and Electric
Garmin 250C Fishfinder
Garmin GPS (New)
New in box VHF radio
Sony stereo
Rayline searchlight
Lowrance 3400 depth instrument
Engine sync meter
Ritchie compass
CruiseAir 10,000 btu reverse cycle air conditioner
Benson electric windlass
Ongaro twin horns
(3) Batteries
30 amp power cord
Guest battery selector switch
Professional Mariner 35 amp charger (New)
The head compartment is to starboard at the companionway stairs.? There is a Jabsco manual M.S.D., a vanity with molded sink and mirrored cabinet above, 29 X 21 teak lined mirror, shower curtain and opening port. Mounted on the outside of the entry door is a12 wide by 47 teak lined mirror.
New sink drains
New faucet
The starboard side galley has a 4 X 34 counter top with molded sink and Kenyon 2 burner Model 214 electric stove with glass cover.? Under the counter is a Norcold refrigerator with storage next to it. Hamilton Beach toaster oven and Continental coffee maker are included. Stainless steel hot water heater mounted in engine compartment.
New sink drains
Additional Information
Starboard engine completetly overhauled October 2011.? Other recent upgrades to the engines include rebuilt seawater pump; replaced impeller, gasket and belt; replaced carbuerator ignition sensor assembly and changed oil and filters. The bottom was?painted in March 2012 and there were no blisters.
Boarding ladder for port or starboard side in cockpit
Igloo Marine elite cooler in cockpit
Transom door
Dripless shaft seals
Twin double helm seats
14 Stainless steel steering wheel
(1) Windshield wiper
Orion flare kit
(4) Gunnel mount rod holders
Fire extinguisher
First aid kit
Full cover Bimini top with side curtains
All new bilge pumps and switches
New zincs
The Company offers the details of this vessel in good faith but cannot guarantee or warrant the accuracy of this information nor warrant the condition of the vessel. A buyer should instruct his agents, or his surveyors, to investigate such details as the buyer desires validated. This vessel is offered subject to prior sale, price change, or withdrawal without notice.
Here you can download an exposé of the current ad. To display the document you will need the Adobe Acrobat Reader which you can obtain here for free.Exposé Download
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City of Detroit Files for Bankruptcy: It is the largest American city ever to do so; its creditors are not happy. Neither are unions:
"Apparently Governor Snyder and Kevyn Orr want Detroit's public service workers to rely on their children for food and shelter, or have to work until they die," said Lee Saunders, president of the American Federation of State, County and Municipal Employees.
Charges Filed Against Marysville Man in Drive-by Shooting That Killed 15-Year-Old: Molly Conley, a Blanchet freshman, was walking with friends in Lake Stevens in June when she was shot in the neck and died. Now Erick N. Walker, 27, has been charged with one count of first-degree murder and four counts of drive-by shooting in Snohomish County Superior Court.
Turns Out He Didn't Exactly Get Permission: The police tactical photographer who released dramatic photos of the capture of Dzhokhar Tsarnaev in response to the Rolling Stone cover has been relieved of duty.
Culprit in the Death of 23 Schoolchildren May Have Been Found: An official in the eastern Indian state of Bihar reports, "Circumstantial evidence suggests that cooking oil was kept in a container which was previously used to store pesticides or insecticides." Children fell violently ill after eating free school lunches on Wednesday.
Is a Malaria Drug to Blame? Staff Sergeant Robert Bales, who was found guilty of murdering 16 Afghan civilians, will be sentenced for the crimes on August 19. But a recent FDA notification hints at a connection to a controversial malaria drug with links to psychotic behavior.
Near-Drowning at Green Lake: A 19-year-old man is hospitalized after two other swimmers pulled him out of the lake last night. Firefighters on scene did 12 minutes of continual chest compressions to get a pulse.
Good-bye, Window Stickers! Now you can pay for street parking in downtown Seattle with your phone.
Aurora Movie Theater Shooting Victims to Wed: On the anniversary of the shooting.
Scientists Study How to Counteract Unconscious Racial Biases: Most effective? Providing study participants with "counterstereotypical messages."
Full-Time Park Rangers in Cal Anderson Park: CHS Blog reports. Rangers are set to be in Cal Anderson seven days a week, 7 a.m. to 10 p.m.


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Fully Licensed & Bonded
General Description:
Marina Club in Lagos has 141 rooms, spread over 4 floors. The hotel is located 800 m from the sandy beach. The closest cities to the hotel are Lagos (500 m) and Portimao (15 km). Other cities: Lisbon (300 km). To make your stay more comfortable air conditioning, a lobby, a reception and a kiosk are available. The staff in this 4 storey hotel speaks Spanish, English, Russian and French. Mobility on holiday is made easy through car, bike and motorbike hire. A playground for children is available. A fresh water swimming pool with an integrated children's pool is available. Refreshing drinks are offered at the pool bar. Sunshades and sunbeds are available for an additional fee at the beach and free of charge at the pool. Accessible from the hotel: Marina De Lagos (100 m), Nautical Sports (100 m), disco (500 m), train station (100 m), Zoo Of Lagos (15 km), airport FAO (80 km), horse riding (10 km), shops (15 km) and Historical Center (500 m). The hotel is within easy reach of bus stops, supermarkets, taxi stands, tourist information, bars and restaurants and medical services.
For convenience the following services are offered: laundry service, wake-up service, ironing service, medical care, babysitting, a safe and room service. Internet access is provided at wifi-hotspots. This family friendly hotel offers a children's pool to ensure a comfortable stay for parents as well as young guests. Reception hours: 24h Service.
The breakfast type is Buffet. Guests are welcome to enjoy their meals at the restaurant. A snack bar is also available throughout the day.
Sport and Leisure:
At Marina Club recreational amenities include a relaxation room, massages, a spa, a sauna and a whirlpool. Guests who wish to be active on holiday can enjoy activities such as exercise in the fitness room. The nearest golf course is 1 km away.
Additional Information:
The following payments are accepted: Visa Card, American Express, Euro/Master Card and Diners Club. Additional fees may apply for certain facilities, amenities or activities.
- Children (under 16 years old) are not allowed at the Spa, except for the swimming pool.


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It's that time of year again, when the heightened anticipation of the newly released spring/summer 2017 ad campaigns hits a climax. Follow us this week as we unveil our collection favourites.
Fusing the release of their S/S17 ad campaign with innovative guerrilla marketing tactics, DKNY had local fans racing around the streets of New York City in a hunt for their new face, Bella Hadid. The images, taken by photographer Collier Schorr, were scattered around the capital in unlikely places with hints to their whereabouts leaked on the label's Instagram. The hashtag #FindBellaDKNY was trending with the brand's devotees in their attempt to win a monetary prize and a chance to meet the supermodel.


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Contact: Jennie Vasarhelyi, CVNP,, 440-546-5990, 440-343-7352 (cell)
Brecksville, Ohio – The National Park Service has reopened the Valley Picnic Area and Oak Hill Trail System in Cuyahoga Valley National Park.
CVNP encompasses 33,000 acres along the Cuyahoga River between Cleveland and Akron, Ohio. Managed by the National Park Service, CVNP combines cultural, historical, recreational, and natural activities in one setting.


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Reacting to a report on his encounter with the lecturers at the university on Monday, Sambo said his responses were not properly captured in the Daily Trust report of the event and that he was not expecting the dons to praise the present administration.Sambo said in a statement by his media aide Umar Sani that, "Contrary to the insinuation by your medium, the vice president was aware that he was speaking to an academic community and was not in any way expecting either praise singing or sycophancy, therefore, for your paper to conclude that there is perception of praise singing was a mere misconception."He said Professor Kabiru Ahmed, who spoke for pensioners claimed that the last time the Central Bank of Nigeria (CBN) released funds for pensioners was nine months ago but that immediately after his question the vice chancellor noted that Prof. Kabiru was a fully employed staff of the institution."The vice president doubted the claim of the CBN being responsible for the disbursement of pensions as opposed to the Office of the Accountant General of the Federation, he however, promised to look into the matter," he said.Sani said the vice president in his response noted that in the beginning they were faced with the challenge of acquiring military hardware and equipment and that Nigerians were aware of their predicament in their efforts to source for the equipment but immediately after the equipment were acquired our military have lived up to expectation and that the war on terror is now almost over.On the fall of the naira, he said the vice president, while responding noted that the economy of the country was substantially an oil dependent one and that it accounted for why they are making efforts on diversification.He said on the issue of election, the vice president stated that he met Prof Jega, only for the first time when he came to the council to defend his budget and that "Mr. President and himself never met Jega before then and were not interested in meeting him so as to allow him discharge his duties equitably."
If you are happy to be contacted by a Daily Trust journalist please leave a telephone
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be published, displaying your name as you provide it and location, unless you state
otherwise. Your contact details will never be published. When sending us pictures,
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Mophie Juice Pack Air for iPhone 5 and 5s
Back at CES 2014, we checked out some of the new products from Mophie, including the new Space Pack smartphone battery/storage cases. Carl, one of our in-house product experts recently took a closer look at the Mophie Juice Pack Air, which provides protection and extra battery life for your iPhone 5 or 5s. Weather's getting warmer, and the arrival of summer means long nights out with friends. Rest assured that your iPhone makes it through all the extra use you'll throw at it with a battery case like the Mophie Juice Pack Air. Check out the video to learn more!


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The new total of $13,38 7,263 is down from the $13,507,129 which was tentatively approved on April 17. T he reduction was made following state review, which denied the township's application for at least $200,000 in extraordinary aid. The amended figure is an increase of $368,132 from the 2000 budget of $13,01 9,131. To foot the new municipal bill, residents will be paying two cents more in municipal taxes. The rate will go from 67 cents to 69 cents per $100 assessed property value. This means that an average home assessed at $211,000 will experience a $42 rise in the municipal portion of their taxes or $20 on an assessment of $100,000.
In April, West Caldwell officials had been hopeful that the state would approve its request for special funds. Not only did the state refuse the extra funding, it reduced a legislative initiative block grant from $88,198 to $45,773.
The amended budget calls for several changes, including a decrease from $213,000 to $71,327 in appropriations for state-required police and fire pension funds.
The budget reflects a $7,500 increase in the natural gas appropriation, which is up from $27,500 to $35,000. An additional $15,000, which is fully funded by the state, has been added to study the feasibility of inter-municipality police services.
The amount appropriated for state-required police and fire pension will go down from $213,900 to $71,327.


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Prices, promotions, styles, and availability may vary. Our local stores do not honor online pricing. Prices and availability of products and services are subject to change without notice. Errors will be corrected where discovered, and Lowe's reserves the right to revoke any stated offer and to correct any errors, inaccuracies or omissions including after an order has been submitted.
Foley 3.5-Quart Stainless Steel Food Mill
Item # 359445 Model # 50025
Product Information
- Perfect for mashing, straining, grating and ricing
- Ideal for natural and healthy food preparation
- Stainless steel construction


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About the Journal
The journal is issued under the name AWAZYMYZ since 1989. Ten years earlier the Karaim youngsters printed and copied some issues of the newsletter and named it COS. Since 1999 the journal is edited by the Karaim Association in Poland. In 1999-2003 there was only the electronic edition, which was distributed between the Karaim communities in Poland and Lithuania. Since 2004 the paper edition is available in black&white and the full colour cover. Since 2007 the paper edition is available in the full colour edition.


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New Delhi, Oct 19: Left-arm paceman Sreenath Aravind was today called into the Indian ODI squad for the remaining 2 matches against South Africa. He has replaced Umesh Yadav in the 15-man squad. R Ashwin, who is injured, has been left out.
Also read: Who is Aravind?
Aravind made his international debut earlier this month against South Africa in the 1st T20I in Dharamsala. However, he was ignored for the next 2 games and was not part of the ongoing ODI series in the first 3 matches. The selectors picked the squad today in Delhi.
The 31-year-old Karnataka bowler took 4 wickets on Saturday (October 17) to help his team take the first innings lead against Vidarbha in the Ranji Trophy.
Umesh, who played in 1st 2 ODIs and dropped for the 3rd against South Africa, was expensive. He took 3 wickets conceding 123 runs in 18 overs at an economy rate of 6.83.
Ashwin, who sustained a side strain during the 1st ODI, is the other man to miss out. However, he was today (October 19) named in the Test squad to face the Proteas. He has more than 2 weeks to recover from the injury as the first Test starts in Mohali on November 5.
South Africa lead the 5-match series 2-1. The visitors won the opener and 3rd game in Kanpur and Rajkot respectively. India tasted success in Indore. The 4th ODI is on Thursday (October 22) in Chennai.
India ODI squad
Mahendra Singh Dhoni (captain and wicketkeeper), Stuart Binny, Shikhar Dhawan, Virat Kohli, Bhuvneshwar Kumar, Axar Patel, Ajinkya Rahane, Suresh Raina, Ambati Rayudu, Mohit Sharma, Rohit Sharma, Sreenath Aravind, Gurkeerat Singh, Amit Mishra and Harbhajan Singh.
In: Sreenath Aravind
Out: R Ashwin (injured), Umesh Yadav
Remaining matches in Ind-SA ODI series
4th ODI in Chennai on October 22 (Thursday)
5th and final ODI in Mumbai on October 25 (Sunday)
OneIndia News


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Since my work is visual, I decided a while ago that Pinterest would the best social media platform to promote this blog and therefore this website.
So I've been learning all about using Pinterest and how to get thousands of followers. Don't know if I'll reach that goal before I turn 80, but I'm sure going to try 🙂 .
If you look at my portfolio, you can see that my designs are clean looking. So every time I would go to my Pinterest profile page and see all my boards, everything looked messy to me.
After finding out I could set up a custom board cover, I went to work on creating them with Canva.com and I'm going to show you how I did it. Take a look at my Pinterest page now.
If you don't have a Canva account, follow the link above and set it up, it's free.
Once in your Canva dashboard, pick "use custom dimensions" at the top right and set it to 564px by 564px and click 'design'.
Next click on Elements and then Shapes and drag the first element, which is a square, to the space.
This is where you will add your board cover titles. Use the same title as what each board is named. You'll need to decide on the background color as well as the font. Play around with different ones but from my experience….
This is what I found works best:
- a lighter color for the background
- a dark color for the text – white doesn't show really white but faded
- a non-script is easier to read and cleaner
- size 36px, but it depends on the font you choose
For my board covers above, I'm using a light blue/green background (my brand color) with black text. Font is Josefin Sans, size 36, bold, line height 1.25 and the image is saved as png.
When you add the text to the image, move it center vertically and while holding the mouse, move it down to 5215 which will show on the left side and that should center it on the board cover.
Once you have one done, download it to your computer. I made a folder to store all the covers.
Go to Pinterest, mouse over the PLUS sign top right and choose upload an image. Choose photo and then save to the board that this image is for. You might have to refresh that page if you don't see the new image on the board.
Now click on that board, and then the pencil at the top, above the board name.
Find the 'cover' and click change. Your new image will show. The text should be in the center, if not you can use your mouse to move it up or down. Save.
Then mouse over your profile face, click my profile. Refresh your page and your new board cover will show up.
What I did is created all my board covers first and downloaded them to my folder. Once they were all done, I went to Pinterest and went through the steps for each board and then refreshed my profile page.
Now admire your clean profile page with easy to read board names.
Let me know if you're having problems. And please share the link to your Pinterest so we can see your handy work.


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Alternative Title: Juan Everardo Nithard
Learn about this topic in these articles:
Spanish history
...IV's widow, Maria Anna of Austria, acted as regent for Charles II (1665–1700). She allowed her government to be dominated by her confessor, the Austrian Jesuit Johann Eberhard (Juan Everardo) Nithard. It was weakness, rather than strength, that prompted this government not to summon the Cortes any more. But this policy paved the way for the introduction of effective royal absolutism in...


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The trails that crisscross the Scenic Rivers area offer hikers of every skill level an opportunity to discover the path less traveled. Many of the hiking areas also offer ample opportunity for canoeing, swimming, camping, and fishing. Some of the areas higher elevations provide a beautiful backdrop for any hiker feeling up to a challenge.
All visitors really need for a spectacular journey is often a good pair of boots, a compass and a canteen of water to get out there and start exploring all that mother nature has to offer.
4124 MS Hwy 24 W
Liberty, MS 39645
Ethel Vance Natural Area is located on the banks of the West Fork Amite River in the extreme southwest portion of the state. Run by the city of Liberty, the seat of Amite County, this park features 10 miles of singletrack trails, popular with mountain biking.
Click Here for more information.
3888 Clear Springs Rd. SW
Meadville, MS 39653
Clear Springs Trail System
Tally's Trail (foot and mountain bike) - 12 miles.
Clear Springs Loop Trail (around lake) - 1 mile
Mill Branch (foot and mountain bike) - 5 miles
Richardson Creek Trail - 7 miles
Percy Quin State Park
2036 Percy Quin Drive
McComb, MS 39648
A well- marked nature trail eight miles (four miles wooded and four miles paved) that circles Lake Tangipahoa and affords observation opportunities of wildlife and plants.
Click Here for more information.
1068 Dogwood Trail
McComb, MS 39648
Explore the woods by hiking the trails of Bogue Chitto Water Park. Trails are open year round offering everyone a pleasant walk in the woods. This hike travels 1.7 total miles through the woods and wetlands along the Bogue Chitto River with waterfalls, swamps, and vistas all packed into one trek. It consists of two loops, one of which travels on bluffs overlooking the Bogue Chitto and another which bisects west.
Click Here for more information.
366 Fort Adams Pond Rd
Woodville, MS 39669
The Clark Creek Natural Area located in the Scenic Rivers region of southwest Mississippi has over 700 of the most beautiful acres in the state. This natural area has over 50 waterfalls ranging in heights from 10-30 feet. These waterfalls and many other wildlife viewing opportunities exist along a 6 mile trail that runs through the breathtaking landscape.
Click Here for more information.


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Watch: Cristiano Ronaldo shows how impossible it is for him to enjoy a quiet cup of tea
Cristiano Ronaldo came up with an original way to promote his latest product, as he settled in for a 'quiet' cup of tea in a Spanish café.
The Real Madrid superstar was a surprise guest as he strolled in and ordered himself a cup of tea, bedecked in the headphones he was trying to sell.
As expected, it didn't take long for a swarm of Ronaldo fans to start flocking in his direction, with his tea drinking becoming virtually impossible as he was constantly asked for photographs until he made his exit.
Ever the businessman, Ronaldo even got a chance to throw in a line to promote his new aftershave range, but his primary objective in this video was to give a plug to his ROC Live Life Loud audio range.
While the former Manchester United star insists at the end of this video that he enjoyed his afternoon out, we suspect this experience may ensure he won't be seen in another coffee shops any time soon.
Online Editors
Promoted Links
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Open thread
For something a little different, let's try a themed open thread. This one: awards, contests, and appearances. Here we go.
- The NQC lineup for the mainstage and showcases is out. The most talked about issue: Ed O'Neal's Dixie Melody Boys being left on the mainstage in this their 50th Anniversary year. David Bruce Murray has given this issue of mainstage vs showcase appearances a lot more thought in general than I have, and recommend his reflections on the situation. But on the DMB issue particularly, I would offer two thoughts. One: it's unarguably tacky and gratuitous for NQC, which has conditioned audiences to expect Dixie Melody Boys on the mainstage, to cut the DMB in what should be a year of celebration for them. But the real question isn't so much why aren't the DMB on this year as it is why weren't they cut long ago. For at least the last ten years, the DMB have shown up on stage with a moribund set of dog-eared tunes sung badly with tracks that sounded like they were recorded on the audio equivalent of a mimeograph machine. This kind of subpar quality is no obstacle to NQC's choice for mainstage appearances, of course, but it's hard to feel too bad for folks who get cut when by all appearances they relied mainly on goodwill and deference to their own longevity to secure their spots at NQC, rather than earning a following with top-notch music that would have made cutting them more difficult. Which is a corollary to my second point: perhaps we should rethink the cult of Ed O'Neal University, the nickname O'Neal and the DMB have acquired because so many of his singers leave so often to sing with better and better known outfits. Because, to quote myself, "is this really a sign that a quartet owner is doing something right?" O'Neal seems like a nice guy with a fine sense of humor and an obvious dedication to gospel music, but all these EOU graduates wanted to work for someone else for a reason.
- From the "and how is this different from every other year," the southern gospel struck out at the Grammys for the most part.
- The SN Fan Awards will be back at Dollywood for a second year since departing NQC. In a long open letter to fans on the issue, the SN makes
a thou protesteth too muchan heroic attempt to explain why this move really is "crucial to the longevity of southern gospel music." And this is probably true, if for you the future of southern gospel is closely linked to the Singing News. Meanwhile, NQC has allegedly "eagerly endorsed" a fan awards showcase at the convention organized around fan-award nominees, and fans will have the chance to vote in some kind of straw poll as well. Compared to the year after the big break, I guess this is progress that NQC and SN can at least cooperate with another. David Bruce Murray compares this new straw-poll-with-showcase arrangement at NQC to the Golden Globes before the Oscars. To my mind, though, there's more of a Cold War detente feeling to all this.
- As you have doubtless seen by now, you can vote for your favorite SN cover. Kyle has rounded up a collection of rugtastic before and after hairpiece covers. Honestly, though, I find that cover with Brian Free as androgynous he-child stranger than all the bad hair pieces atop so much insecure masculine vanity.
- Dove Award nominees are out. Burke has a round up of sg-related nominations.
- Finally, a bonus clip, via southerngospelcritique, which, in keeping with our theme, I hereby nominate for the Best Worst Pornstache in Southern Gospel Award. There are several to choose from, but right now I'm leaning toward Scott Fowler's. Lumberghs of the world unite.
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©2011 gary garbett.com
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Today is no different.
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|Publication number
|Publication type
|Application number
|Publication date
|Aug 21, 1990
|Filing date
|Oct 16, 1987
|Priority date
|Oct 16, 1987
|Fee status
|Also published as
|Publication number
|Reeta Mehta, Gabriel Lopez-Berestein
|Original Assignee
|Board Of Regents, The University Of Texas System
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (34), Non-Patent Citations (9), Referenced by (33), Classifications (15), Legal Events (7)
|External Links: USPTO, USPTO Assignment, Espacenet
The present invention relates to a composition of matter usable to form liposomes comprising antifungal polyene macrolides and the production thereof.
Clinical observations and animal experimental studies have added to the understanding of host-fungal interactions. It is becoming recognized that host defense against fungal disease is multifactorial and may vary, depending on the etiologic agent. The mechanisms of resistance are not well defined in most instances, but various innate barriers and cell-mediated immune responses seem to be of primary importance. Clearly, debilitation of innate defenses and of cell-mediated immune responses can increase an individual's susceptibility to severe fungal disease from opportunistic agents such as Cryptococcus neoformans and species of Candida and Aspergillus, as well as from fungal pathogens such as Histoplasma capsulatum and Coccidioides immitis. The difficulty in gaining a complete understanding of the critical host defenses has been further complicated by many studies that show fungi may affect various host immune functions adversely. Although it is too early to evaluate the clinical importance of many of these experimental findings, investigators have demonstrated that fungi impair neutrophil function, induce IgE responses, and cause suppression of cell-mediated immune responses.
Host changes likely to be associated with increased susceptibility may be accidentally induced, as in traumatic injuries (such as burns or puncture wounds); selfinduced, as in chronic alcoholism; naturally occurring, as in diabetes mellitus, various congenital immune deficiencies, collagen diseases, lyaphoreticular neoplastic disease, and other types of tumors; or iatrogenically induced by instrumentation (such as catheterization), surgical procedures (such as open heart surgery), or by use of cytotoxic drugs (as in an attempt to prevent graft rejection and to treat neoplastic disease), corticosteroid therapy, and long-term use of broad-spectrum antibiotics.
Chemical factors that aid resistance to fungal diseases are poorly defined. Knowledge of these substances is based primarily on circumstantial evidence at the clinical level and in vitro observations at the experimental level. Hormonally associated increases in lipid and fatty acid content on the skin occurring at puberty have been correlated with increased resistance to tinea capitis caused by the dermatophyte Microsporum audouinii, although pubescent changes are not the sole factors in resistance. Substances in serum, cerebrospinal fluid, and saliva may limit growth of Cryptococcus neoformans, and basic peptides in body fluids have been shown to inhibit Candida albicans.
Results of clinical and experimental studies indicate that C. albicans, C. neoformans, Aspergillus fumigatus, and C. immitis activate the alternative pathway of the complement cascade. Because of the polysaccharide nature of fungal cell walls, it is expected that all medically important fungi activate complement. Such activation may be important in defense against some mycoses; a positive correlation has been demonstrated between animals deficient in late-acting complement components (C3-C9) and increased susceptibility to fungi such as C. neoformans and C. albicans. Assuming that phagocytic cells are important in resistance to fungi, complement activation may play a role by provoking an acute inflammatory response on generation of complement fragments C3a and C5a, and by coating the fungal elements with opsonic fragments C3b and C3d for ingestion by phagocytic cells.
The systemic mycoses of humans and other animals are caused by some fungi that are pathogenic and cause disease in the healthy host, and by other fungi (opportunistic pathogens) that are usually innocuous but cause disease in patients whose immune defenses are impaired. Some of these fungi may be saprophytes in nature (soil, bird droppings), whereas others are a part of the normal human flora (commensals). In no case are humans the solitary or necessary host.
An example of a soil saprophyte is Histoplasma capsulatum, which commonly causes infection in endemic areas; 80%-90% of adults react positively to histoplasmin in delayed cutaneous hypersensitivity tests. An example of an opportunistic pathogen is Candida albicans, normally present in the oral cavity, gastrointestinal tract, and probably the skin. In the patient with acute leukemia, however, C. albicans is commonly present in blood, causing a fulminant, usually fatal, septicemia. Other opportunistic infections are seen in patients with diabetic acidosis (mucormycosis) and Hodgkin's disease (for example, cryptococcosis and histoplasmosis). The pathogenesis of these mechanisms is obscure, but cell-mediated immunity seems to be essential for a good prognosis.
Neither active vaccines nor passive immune serum immunization has been sufficiently successful to result in commercially available preparations.
Treatment of active disease may be symptomatic (for example, pain relief), sometimes surgical (resection of irremedially damaged tissue and correction of hydrocephalus), and, most successfully, chemotherapeutic (Table 1). Among the chemotherapeutic agents commonly used are hydroxystilbamidine isethionate, amphotericin B, 5-fluorocytosine (Flucytosine), miconazole, and ketoconazole. Response to these drugs varies according to the fungus, type of disease, and course of illness. For example, response is good in most B. dermatitidis infections, but is poor in most diseases caused by A. fumigatus. Response is better for skin lesions caused by B. dermatitidis than for meningitis due to C. immitis; response is better in chronic cryptococcosis than in fulminant candidiasis. Table 1 shows a listing of some systemic mycoses and generally accepted chemotherapeutic agents.
TABLE 1______________________________________CHEMOTHERAPEUTIC AGENTS FORSYSTEMIC MYCOSESDisease First Choice Second Choice______________________________________Aspergillosis Amphotericin B KetoconazoleBlastomycosis Amphotericin B Hydroxystilbamidine isethionateCandidiasis Amphotericin B Flucytosine or ketoconazoleCoccidioidomycosis Amphotericin B KetoconazoleCryptococcosis Amphotericin B Either drug alone* FlucytosineHistoplasmosis Amphotericin B Ketoconazole*Mucormycosis Amphotericin B Miconazole*Paracoccidioidomycosis Amphotericin B Sulfonamides, Ketoconazole*______________________________________ *Depending on minimal inhibitory concentration necessary for the fungus.
Infection is the cause of death in 51% of patients with lymphoma and 75% of patients with leukemia. Although bacteria are the causative organisms of many such infections, fungi account for 13% of the fatal infections in patients with lymphoma and for more than 20% of patients with leukemia. The fungus Candida albicans causes more than 80% of these infections, and Aspergillus spp. is also a frequent cause of such infections. In addition, fungal infection is a major cause of morbidity and mortality in patients with congenital and acquired deficiencies of the immune system. Much concerted effort has been expended in search of agents useful in treating fungal infections of humans. As a result, many compounds have been isolated and shown to have antifungal activity, but problems associated with solubility, stability, absorption, and toxicity have limited the therapeutic value of most of them in human infections. The most useful antifungal antibiotics fall into one of two categories: those that affect fungal cell membranes and those that are taken up by the cell and interrupt vital cellular processes such as RNA, DNA, or protein synthesis. Table 2 lists some useful antifungal agents and their mechanisms of action.
TABLE 2______________________________________SOME USEFUL ANTIFUNGAL AGENTS,THEIR CHEMICAL CLASSIFICATION,AND THEIR MECHANISMS OF ACTIONClass Compounds Mechanism______________________________________Polyene Amphotericin B Interacts with sterols Nystatin (ergosterol) in fungal cell membrane, render ing cells selectively permeable to the outflow of vital constituents, e.g. potassiumImidazole Miconazole Inhibits demethylation of Clotrimazole lanosterol thus Ketoconazole preventing formation of ergosterol, a vital component of fungal cell membrane; also has a direct cidal effect on fungal cellsPyrimidine 5-Fluorocytosine Is taken up and deaminated by susceptible cell to form 5-fluorouracil, which in turn inhibits RNA synthesis; also thought to inhibit thymidylate synthetase and DNA synthesisGrisan Griseofulvin Binds to tubulin and inhibits microtubule assembly3-Arylpyrrole Pyrrolnitrin Appears to inhibit terminal electron transport between succinate or NADH and coenzyme QGlutaramide Cycloheximide Inhibits protein synthesis at 80S ribosomal level preventing transfer of aminoacyl tRNA to the ribosome______________________________________
The polyene macrolide antibiotics are secondary metabolites produced by various species of Streptomyces. Several common features of these compounds are useful in classifying the more than 80 different polyenes that have been isolated. All are characterized by a macrolide ring, composed of 26-38 carbon atoms and containing a series of unsaturated carbon atoms and hydroxyl groups. These features of the molecule contribute to the polyenes' amphipathic properties (those relating to molecules containing groups with different properties, for example, hydrophilic and hydrophobic). The ring structure is closed by the formation of an internal ester or lactone bond (FIG. 1). The number of conjugated double bonds vary with each polyene, and the compounds are generally classified according to the degree of unsaturation.
Toxic effects of polyene macrolides appear to be dependent on binding to cell membrane sterols. Thus, they bind to membranes of fungus cells as well as to those of other eukaryotic cells (human, plant, and protozoa), but not to bacterial cell membranes, which do not contain membrane sterols. The interaction of polyene macrolides with mammalian and fungal membrane sterols results in transmembrane channels that allow the leakage of intracellular components leading to cell deaths.
The usefulness of an antibiotic is usually measured by the differential sensitivity of the pathogen and host. Two polyene macrolides agents, nystatin and amphotericin B, are relatively specific for fungi and have thusfar proven to have therapeutic usefulness in humans. The relative specificity of these two polyene macrolides may be based on their greater avidity for ergosterol, the principal sterol of fungal membranes, compared to cholesterol, the principal sterol of human cell membranes.
Amphotericin B is a heptaene macrolide with seven resonating carbon bonds. The compound was first isolated from broth filtrates of S. nodosum in 1956. Like other polyene macrolide antibiotics, amphotericin B is insoluble in water. The problem of its solubility has been circumvented by combining the antibiotic with sodium deoxycholate and sodium phosphate and hydrating the mixture with sterile water or saline. Amphotericin B is the polyene antibiotic thusfar most sufficiently nontoxic to humans that it has been used parenterally at effective doses against various fungi.
Nystatin, first isolated from S. noursei, is structurally related to amphotericin B, but is not classified as a heptaene because the conjugated portion of the ring is interrupted and thus forms a tetraene and a diene. Tolerated well both orally and topically, the drug is not available for intravenous use because of its presumed high toxicity and aqueous insolubility. Nystatin is available as oral tablets (500,000 units) or as an ointment for topical use (100,000 units/g). It is used in the management of cutaneous and mucocutaneous candidiasis.
It has recently been shown that the encapsulation of certain drugs in liposomes before administration to the patient can markedly alter the pharmacokinetics, tissue distribution, metabolism and therapeutic efficacy of these compounds. Liposomes may be defined as lipid vesicles which are formed spontaneously on addition of an aqueous solution to a dry lipid film. Further, the distribution and pharmacokinetics of these drugs can be modified by altering the lipid composition, size, charge and membrane fluidity of the liposome in which they are encapsulated.
Recently, liposomes have been used as carriers of amphotericin B for treatment of murine leishmaniasis (New, R.R.C., et al., "Antileishmanial Activity of Amphotericin and Other Antifungal Agents Entrapped in Liposomes." J. Antimicrob. Chemother., Vol. 8 (1981), pp. 371-381), histoplasmosis (Taylor, R.L., et al., "Amphotericin B in Liposomes: A Novel Therapy for histoplasmosis." Am. Rev. Respir. Dis., Vol. 125 (1982), pp. 610-611), cryptococosis (Graybill, J.R., et al., "Treatment of Murine Cryptococosis with Liposome-Associated Amphotericin B." J. Infect. Dis., Vol. 145 (1982), pp. 748-752). and candidiasis (Tremblay, C., et al., "Comparative Efficacy of Amphotericin B (AMB) and Liposomal AMB (lip-AMB) in Systemic Candidiasis in Mice." Abstr. 1983 ICAAC, No. 755 (1983), p. 222). Liposome-encapsulated Amphotericin B has also been used for treatment of coccidioidomycosis in the Japanese macaque (Graybill, J.R., et al., "Treatment of Coccidioidomydosis (cocci) in Primates Using Liposome Associated Amphotericin B (Lipo-AMB)." Abstr. 1982 ICCAC, No. 492 (1982), p. 152).
The treatment of fungal infections remains a major problem in spite of the availability of effective antifungal drugs such as the polyenes. Most of the available polyene antibiotics have toxic side effects that limit their clinical application. Nystatin, a tetraene-diene polyene macrolide antibiotic, has high hydrophobicity, which has precluded its effective systemic administration. It has been used as suspensions prepared in various ways and administered to the patients orally. However, these studies have generally failed to document a beneficial effect of nystatin administration against systemic fungal infections.
The present inventors have recently demonstrated that liposome-encapsulated amphotericin B may be used to treat experimental murine candidiasis (Lopez-Berestein et al., J. Infect. Dis., Vol. 150, pp 278-283 (1984) and in the treatment of fungal infections in patients with leukemia and lymphoma (Lopez-Berestein et al., J. Infect. Dis., Vol. 151, pp 704-71 (1985).
The present invention involves a process for producing fine powder suitable for the preparation of antifungal polyene microlide-containing liposomes upon suspension in an aqueous solution. This process comprises the following steps. Quantities of polyene macrolide and phospholipids are dissolved respectively in a first solvent and a second solvent to form a first solution and a second solution. The first solution and the second solution are mixed in a desired ratio to form a mixture. The first solvent and the second solvent are then removed from the mixture, for example by evaporation, to form a residue. The residue is then dissolved in a third solvent comprising tertiary butanol and methylene chloride to form a third solution. The third solvent is then extracted by evaporation from the third solution to form a remnant. The remnant is then dissolved in a solvent consisting essentially of tertiary butanol to form a fourth solution. The fourth solution is then filtered through a filter having orifices of between about 0.05 and 0.5 micrometers in diameter to produce a filtrate. The filtrate is lyophilized to remove the tertiary butanol and a fine powder remains. This fine powder may be used to form polyene macrolide-containing liposomes by simple incubation or suspension in an aqueous solution.
A stable powder suitable for the direct preparation of liposome-incorporated antifungal polyene macrolides may be made by a process of the present invention. While the conditions described herein are specifically applicable to nystatin and amphotericin B, other polyene macrolide antifungals may be likewise used, but with minor modifications of procedure apparent to those skilled in the art upon a minimal amount of experimentation.
The process for pre-liposomal polyene macrolide powder formation of the present invention involves dissolution of an antifungal polyene macrolide such as nystatin or amphotericin B in a first organic solvent such as methanol to form a first solution. Phospholipids are dissolved in a second organic solvent such as, for example, chloroform, to form a second solution. The first solution and the second solution are mixed to form a first mixture having a ratio of antifungal polyene macrolide to phospholipid between about 1:5 and about 1:50, preferably of about 1:10. The organic solvents are removed from the mixture, for example, by solvent evaporation under reduced pressure and at a temperature between about 35� C. and about 45� C., until a residue such as a dry film is formed. The residue is then dissolved in a quantity of a third organic solvent such as a mixture of tertiary butanol and methylene chloride in a ratio between about 2:1 (preferred for nystatin) and about 1:40 (preferred for amphotericin B) and the solvent evaporated to leave a remnant. The remnant is dissolved in a solvent consisting essentially of tertiary butanol to form a fourth solution which is warmed, if necessary for clarification, and passed through a filter having orifices of between about 0.05 and 0.5 micrometers (um) in diameter. If warming is desired to clarify the fourth solution, particularly with amphoterecin B, the warming is preferably to a temperature between about 50� C. and about 70� C. The filtrate is subjected to freezing, for example, with dry ice-acetone. The frozen material is then lyophilized until essentially all solvent is removed. After lyophilization, a fine pre-liposomal polyene macrolide powder is produced. This powder is readily and stably stored under commonly available dry and cool storage conditions.
The above-described pre-liposomal polyene macrolide powder may be easily used to reconstitute a liposome suspension according to the following general procedure. The powder is added to an aqueous solution such as pyrogen-free saline, and allowed to incubate at 25� C. to 45� C. for 1-10 minutes for a liposome suspension to form. Polyene macrolide content may be measured by dissolution of the liposomes in methanol and monitoring of optical density at a wavelength characteristic for polyene macrolide absorption.
Representative, suitable phospholipids in the present invention are phosphatidylcholine, both naturally occurring and synthetically prepared, phosphatidic acid, phosphatidylserine, phosphatidylethanolamine, sphingolipids, phosphatidyglycerol, spingomyelin, cardiolipin, glycolipids, gangliosides, cerebrosides and the like used either singularly or intermixed such as in soybean phospholipids.
More particularly useful phospholipids include egg phosphatidylcholine, dilaurylphosphatidylcholine, dimyristoylphosphatidylcholine, dipalmitoylphosphatidylcholine, distearoylphosphatidylcholine, 1-myristoyl-2palmitoylphosphatidylcholine, 1-palmitoyl-2-myristoyl phosphatidylcholine, 1-stearoyl-2-palmitoyl phosphatidylcholine, dioleoylphosphatidylcholine, dilauryloylphosphatidylglycerol, dimyristoylphosphatidylglycerol, dipalmitoylphosphatidylglycerol, distearoylphosphatidylglycerol, dioleoylphosphatidylglycerol, dimyristoyl phosphatidic acid, dipalmitoyl phosphatidic, dimyristoyl phosphatidylethanolamine, dipalmitoyl phosphatidylethanolamine, dimyristoyl phosphatidylserine, dipalmitoyl phosphatidylserine, brain phosphatidylserine, brain sphingomyelin, dipalmitoyl sphingomyelin, and distearoyl sphingomyelin.
The lipid composition of both the initial powdered composition of matter and the resultant liposomes, formed in accordance with the present method, is normally the same. Where the resultant liposomes are intended for in vivo applications (such as drug delivery), then it is normally desirable that the lipid composition have a transition temperature below body temperature. Liposomes composed of phospholipids which have transition temperatures below the characteristic gel-liquid crystalline phase transition temperature of biological membranes, i.e. about 37� C., are considered fluid and those which have transition temperature above 37� C. are considered solid. Another consideration in selecting the composition of lipid or lipids for liposome applications is that alkyl-ether linked lipids (rather than ester linked) are more stable to hydrolysis, and hence alkylether linked lipids for the resultant liposomes may be particularly desirable for therapeutic application.
In addition, other lipid-like substances such as steroids, cholesterol, aliphatic amines or acids such as long chain aliphatic amines or carboxylic acids, long chain sulfates and phosphates, dicetyl phosphate, butylated hydroxytoluene, tocopherol, and isoprenoid compounds may be intermixed with the phospholipid components to confer certain desired and known properties on the initial liposomes and hence the resultant liposomes. Further, synthetic phospholipids containing either altered aliphatic portions, such as hydroxyl groups, branched carbon chains, cycloderivatives, aromatic derivatives, ethers, amides, polyunsaturated derivatives, halogenated derivatives, or altered hydrophillic portions containing carbohydrate, glycol, phosphate, phosphonate, quaternary amine, sulfate, sulfonate, carboxy, amine, sulfhydryl, imidazole groups and combinations of such groups, can be either substituted or intermixed with the phospholipids.
The antifungal polyene macrolides of the present invention include nystatin, amphotericin B, partricin and derivatives thereof such as methyl esters.
These examples are presented to illustrate preferred embodiments and utilities of the present invention and are not meant to limit the present invention unless otherwise stated in the claims appended hereto.
A solution of 25 mg nystatin in 25 ml methanol was mixed with a solution of 175 dimyristoylphosphatidylcholine (DMPC) and 75 mg dimyristoylphosphatidylglycerol (DMPG) in 10 ml chloroform. The DMPC:DMPG ration was 7:3 and the nystatin:DMPC+DMPG ration was 1:10. The organic solvents were then evaporated at 40� C. under partial vacuum in a rotary evaporator until a dried lipid film was formed. Thirty ml of 2:1 mixture of tertiary butanol and methylene chloride were added to dissolve the dried lipid film. The organic were then evaporated from the solution at 40� C. and under partial vacuum to form a lipid residue. The lipid residue was dissolved in tertiary butanol and the solution passed through a 0.2 um filter. The nystatin concentration was measured from an aliquot of the filtrate. The filtrate was frozen by immersion of a container in dry ice-acetone. The frozen material was subjected to overnight lyophilization and a fine preliposomal nystatin powder produced.
A 100 mg sample of the fine powder (containing about 10 mg nystatin) was suspended with 10 ml of pyrogen-free saline. When the powder suspension was warmed at 40� C. for 2-5 minutes, liposomes were formed therein. As determined by microscopic examination, the suspended materials were 100% liposomes were formed therein. As determined by microscopic examination, the suspended materials Were 100% liposomes and no crystals were found. The suspension was centrifuged at 20,000 rpm (40,700�g) for one hour and the resultant pellet removed and resuspended in saline. The nystatin remaining in the resuspended pellet was determined to be 70-80 percent of the original amount added, by dissolution in methanol and measurement of optical density at 306 nm. The encapsulation efficiency of the liposomes, as measured after the filtration step, was observed to be >99%. (No detectable free drug was left after formation of liposomes from the powder). The resuspended pellet was a liposome preparation substantially free of soluble lipids or other materials and was suitable for clinical administration.
Amphotericin B in methanol and phospholipids (DMPC:DMPG, 7:3) in chloroform were mixed together in a ratio of 1:10. The organic solvents were then evaporated at 40� C. using a rotary evaporator under vacuum.
Tertiary butanol and methylene chloride in a 1:30-40 ratio were added to solubilize the dried lipid film. The organic solvents were then evaporated.
The residue in the flask was then dissolved in tertiary butanol, warmed to temperatures above 52� C., and filtered through a 0.2 um filter. An aliquot from this filtrate was taken to determine the amphotericin B concentration.
The above mixture was then frozen (using dry ice with acetone) and lyophilized overnight. A fine powder was obtained.
The powder obtained as described above was suspended in pyrogen-free saline. The liposomes did not form until the suspension was warmed in a water bath at about 40� C. for about 2-5 minutes. The suspension then formed 100% liposomes (no crystals), as they appeared under a microscope. The suspension was centrifuged at 20,000 rpm for one hour and the pellet removed and resuspended in saline. An aliquot was taken from this final suspension and the amount of amphotericin B incorporated into liposomes quantitated by dissolving in methanol and measuring O.D. at 405 nm. The encapsulation efficiency of drug from the powder to liposomes was 99-100%.
Changes may be made in the elements and methods described herein or in the steps or the sequence of steps of the method described herein without departing from the concept and scope of the invention as defined in the following claims.
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|International Classification
|Cooperative Classification
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|Oct 16, 1987
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text:
Spieth: Day like Tiger in his prime
Jason Day's recent performances are reminiscent of Tiger Woods in his prime - and that's coming from Jordan Spieth, who spent the last two days in awe of the Australian's scintillating form in the $8.25m BMW Championship at Conway Farms, Illinois.
Spieth, winner of the Masters and US Open, has had to bow the knee to Day over the last month during which the Australian triumphed in the US PGA Championship and The Barclays, the first of the four FedEx Cup play offs.
Day completed his first round at 7.30am due to Thursday evening's suspension of play caused by a thunderstorm in the Chicago area with a ten-under-par 61.
He then proceeded to carve a swathe through the field for a 63 which included holing a 40-foot putt for eagle on the last to take him to 18 under for the tournament.
That gave him a five-shot lead ahead of Daniel Berger and Brendon Todd on 13 under par.
Spieth played alongside Day and Rickie Fowler, winner of the Deutsche Bank championship two weeks ago, and they were left gasping for air in Day's exhaust fumes.
"I've seen it now for four events first hand alongside Jason from the Sunday at the PGA, through the first two rounds of the last two tournaments and here, and it's an incredible display of golf," said Spieth.
"He's hitting it the longest, the straightest. He's putting the best. When I say it, it sounds a lot like people told me when Tiger was in his prime.
"Obviously it's a little soon to say that, but the golf he's played here is tough to play alongside.
"When he's getting so deep under par and you're trying to catch him, you get too aggressive and that's where my mistakes were."
The Texan finished on a high with an eagle on the par-five 18th for a 66 which left him tied for fourth place on 11 under alongside Kevin Na, who also shot 66.
Day hopes the dream golf will continue over the next two days.
"It's been a great summer for me. I've just got keep rolling with this, I've just got to keep pushing forward," said Day.
Rory McIlroy, making only his third competitive appearance since he fractured an ankle ligament in early July, mixed some impressive driving and iron play with a couple of lapses on the greens that left him frustrated.
Many other pros in the tournament would be delighted with 68, 65 for nine under par going into the weekend but McIlroy knew it could have been even better.
"I feel like I've left a lot of shots out there the last couple of days," he said.
"The course is obviously playing quite easy. You can see that from the scores out there.
"I feel like I played well today. No bogeys on the card, but I'm disappointed at how I finished on the last four holes and not picking any shots up there. I wish I could have got to double digits under par.
"But if I go really low over the weekend, I have a chance."
Earlier, McIlroy was buoyed up by his shot of the day, a 42-yard pitch following a 310-yard drive for an eagle two on the seventh hole.
"This was nice. I took advantage of hitting a good drive, and the pitch went in a little speedy, but it was nice to see one drop and it kick-started the round a little bit," he said.
The going was soft following a storm on Thursday evening and more rain early yesterday morning, so placing was allowed.
On the European Tour, Peter Lawrie was the best of the Irish in the Italian Open at Golf Club Milano.
Lawrie's 68, 67 for nine under par left him just four shots off the lead held jointly by Jens Fahrbring (Sweden) and Denmark's Lucas Bjerregaard who shot 64 and 65 respectively and set the pace at 13 under.
Padraig Harrington (70), Darren Clarke (70) and Paul McGinley (72) all qualified on the cut line at four under par.
Rookie pro Gavin Moynihan (73, 76) ended a tumultuous week following the Walker Cup win and turning pro with a valuable learning experience, albeit that he missed the cut on five over par.
Also going home early were Simon Thornton (-1), Kevin Phelan (+1) and Damien McGrane (+2).
Italian Open
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Solheim Cup
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BMW Championship
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Irish Independent