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Hi ladies - I just searched way back to early August on our old thread and dug out this roll call. I'm not sure if it's right for you - if not feel free to correct it!
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26-09-2012 15:32 #71
Roll call
26-09-2012 15:59 #72Senior Member
- Join Date
- Jul 2011
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- Sydney
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- Thanked
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26-09-2012 19:33 #73
Thanks Bella yes we have hijacked the thread a bit but it's all been useful .. Ill keep lurking on the other threads in the meantime .
Ps thanks for updating the roll. Yes I am still in limbo land !
Paddlegirl wow that is a bit move to Perth and what change it will be. I too loved Perth when I went a few years ago, in fact the whole WA coast was amazing. Your father must be very chuffed to have you around .
29-09-2012 10:43 #74
Hi everybody
A me post with all my important news of the past 3 weeks.
We're back home now. The twins were discharged from hospital yesterday, at 2 wks old.
That was an exciting trimester for us. I don't recommend anyone else try copying the stressful events.
Andrew was home from intensive care for a few weeks and my oedema was slowly getting worse, but on Sunday 9 Sep my blood pressure started heading up - 140/90 ish. At my scheduled Ob appt on Monday 10 my bp was 160/100 or so, so it was straight to hospital for me. (I'd gone to the Ob appt with an overnight bag because I knew everything wasn't going perfectly anymore.) We managed to stay healthy enough to keep the bubs in until the Friday (14 Sep). I knew the oedema had reached above my hips when one evening in hospital I couldn't arch my back properly anymore, but hadn't realised how much fluid I'd collected even on my face and wrists until it went away.
I got to watch part of the C-section in the reflection off the theatre lights, so I knew when the bubs were about to be born which was great. It also got to see that it wasn't a straightforward operation when I saw them shoving some towels into my uterus. They estimate I lost 1.5-2 L of blood, and I got a transfusion of 3 units too. My Dr had warned me before surgery the risk of haemorrhage was increased because of a more stretched uterus from carrying twins and she was really calm during the whole operation so I was nice and calm too. It probably didn't help things that in the 12 hours before the caesar Stuart had decided to switch from breach presentation to transverse. Apparently transverse is still quite difficult to deliver by caesarian and one of the other Drs in theatre congratulated my Ob on nicely getting him out from a difficult position.
Then as a consequence of the preeclampsia my nerves/reflexes got overactive so I had to have a magnesium drip for 24 hours. So the twins were about 36 hours old before I got to cuddle them properly. They were born at 35+4, weighing just under 2.5 and 2.0 kg, and were put on NG feeds because they weren't quite old enough for a proper suck reflex. But apart from that and receiving a bit of colostrum after the birth they didn't require any other special intervention. No lung trouble or humidicribs or anything like that.
So, what with stacking up all those things that could have gone better, we're still working on getting my milk to come in properly, but it looks like the bubs are able to get a bit of a feed off the boob now before we have to top them up with formula. Fortunately they're both willing to feed off boob and bottle, because that meant we could remove the NG tubes and come home without having to wait for me to develop a proper milk supply or having to decide to give up on boob altogether. The paediatrician has limited their boob time per feed (before topping up with bottle) so that they don't run out of suck energy before getting enough nutrition. They'll be coming up to 38 wks on Monday.
The caesar didn't hurt. I just had panadol 4 times a day to help with tenderness. It's just as well it didn't hurt too, because while I was spending my 36 hours in the High Dependency Unit one of the nurses who was trying to lower the side-rails of the bed instead pressed the "emergency lower the bed flat now for CPR" button. That was a bit of a surprise.
The bubs have been really well behaved since coming home yesterday. I suspect a trap and that they're just waiting for me to send my mum home before they start crying a lot .
It's just about time for the next feed, but I'll try to get back on for personals some time soon.
30-09-2012 19:24 #75
Hi all -
Great to hear you're home with bubs Felicita - I updated the roll call so you're now in the Mummies section I was at Bunnings today and the sausage sandwich stall was being run by the Nepean Multiple Births Association - I wondered if you'd heard of them - not sure of the support they offer but might be worth a look.
Have also been thinking that EternalOptimist must be due soon - anyone heard from her?
Hi everyone else - hope you're having a great long weekend
AFM - 2nd BT/US in the morning. Had 7 follies on Friday and have felt lots of niggles all weekend, so hoping for EPU on Wed. Also had an Intralipid Infusion on Friday to try and suppress my NK cells so hopefully we're on our way to that elusive BFP!
Sydney Girls Roll Call
Waiting to Cycle
(limbo land, on a break, between cycles, etc)
Cycle Underway
(IUI, IVF, ICSI, FET, etc)
(note: if your BT date is wrong, please help yourself to correct it )
EternalOptimist- Oct 2012
Kelbelle- Nov 2012
Quartz- Nov 2012- TWINS!!
Catfroggy- Nov 2012
romaverona- Dec 2012
Traveler- Feb 2013
Nat84u - Mar 2013
The Time Has Come - Mar 2013
Proud Mummies
Nat84u - DD 2004
PinkButterfly- DD1 2007 & DD2 Feb 2012
Traveler- DS 2009
Lola77- DS 2009
Loulabelle- DD1 2009 & DD2 Mar 2012
The Time Has Come- DS Aug 2010
25andhopeful - natural miracle- DD Apr 2012
Claire77 - ???? Jul 2012
Bebehvala - DS Aug 2012
Felicita - DS & DD Sep 2012
01-10-2012 04:33 #76Senior Member
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Hi All,
Ok a quick update from us. Sorry we have been MIA but u really hate that the app is gone!
Dp has been seeing a acupuncturist and Chinese herbalist. She's been taking herbs, we've changed our diet somewhat and DP has been stabbing away.
Fet scheduled for Wednesday! this is the one and that some of our embies survive the thaw this time.
02-10-2012 20:50 #77
Just a quick one to see how Bella & Peonies are going with their cycles!?
Bella-EPU still going ahead tomorrow!? Wishing you the best of luck if thats the case!! Fingers crossed for lots of beautiful eggies!!
Peonies-where are you up to sweety!? Have you had FET yet? Sending you tons of baby dust!!!
Felicita-congrats again on your gorgeous babies!! What a full on pregnancy you had, I bet each second witb those bubs is worth all the hard work getting here.
I should be back tomorrow with some proper personals!
03-10-2012 07:48 #78
just a quick note to say hello and an update.
Our BFP in 6.5 weeks turned into a BFN
Up to that point, Linda had the usual cravings, changes in boobs everything. We went for the scan and the FS was shocked not to see anything, right at the end of the scan she thought she saw what looked like a very deflated sac.
BT confirmed that the HCG levels weren't high enough and the other levels had dropped.
Well that was a week last Thursday, and Linda still hasnt had any bleeding. Had a BT this morning to see whats happening.
We have four frosties so hope they survive the thawing out.
03-10-2012 19:45 #79
Hi Ladies!
Felicita - congratulations mama!! What an ordeal the last couple of months have been. Hopefully now with your precious twins here and Andrew home from hospital, life has become a lot more rosey. Nice to hear from you. Can't wait to see pics of Edwina & Stuart.
Bella - thanks for updating the roll call! I've been a bit slack. Did you have EPU today? Hope it went well. this is your lucky cycle. I heard from Eternal Optimist a couple of weeks ago - I sent her a PM asking her about her lucky FET protocol and she replied, but haven't heard anything more recently.
Catemer - good luck with this cycle! Gee, your DP must have short cycles to be ready for FET again already. Hope this is the one!
TTHC - how are you going, my dear? Thanks for checking in.
Romaverona - how are you going love?
Fingerscrossed - so sorry again about your m/c. You must both be devastated.
AFM: I am okay, just plodding along waiting to ovulate. This is a natural FET, but with Pregnyl. I have a bit of a long cycle so it's CD16 today. First couple of BTs had not much happening, e2 around 150. Yesterday it was 330, so another BT tomorrow and 1st scan. Hopefully lining is coming along ok. I reckon I'll O on the weekend, with FET on Thurs or Fri next week (if frosty thaws).
BUT, have had some other exciting developments. After the last failed cycle we started to think again about an approach other than IVF. I can't recall if I mentioned this before or not, but last year when DH was diagnosed we were looking into finding a private donor arrangement and trying at-home insemination (turkey baster style ) and I was even communicating with a guy at that time. But then my surgeon sent us over to Dr Golovsky and we were off on the IVF bandwagon. Well, as we know, he didn't find any sperm in DH and we used the donor sperm, BFP then m/c and somehow we went straight into a 2nd stim cycle with IVFA without really thinking about it. But DH doesn't want me doing another stim cycle this year and he hates how hard the whole thing is on my body. I was thinking again about a private donor arrangement so we looked into this again. My FS agreed that there is no reason why I shouldn't be able to fall pregnant "naturally".
Soooooo (sorry, long story), we have found a donor. We met him on the weekend, have seen his blood tests, semen analysis, etc. He has 3 kids with his wife & has achieved 2 pregnancies so far via donating (and only started in April) so I feel good about his fertility. The plan is that, if this FET doesn't work, we'll get straight to work with "Sperm Guy" next month.
03-10-2012 20:38 #80Hi ladies,
Just a quick one - I'll do personals tomorrow. I did have EPU today and got 13 eggs Will hear tomorrow morning how many fertilise.
Sydney Girls Roll Call
Waiting to Cycle
(limbo land, on a break, between cycles, etc)
Cycle Underway
(IUI, IVF, ICSI, FET, etc)
(note: if your BT date is wrong, please help yourself to correct it )
Bella978 - BT 19/10
EternalOptimist- Oct 2012
Kelbelle- Nov 2012
Quartz- Nov 2012- TWINS!!
Catfroggy- Nov 2012
romaverona- Dec 2012
Traveler- Feb 2013
Nat84u - Mar 2013
The Time Has Come - Mar 2013
Proud Mummies
Nat84u - DD 2004
PinkButterfly- DD1 2007 & DD2 Feb 2012
Traveler- DS 2009
Lola77- DS 2009
Loulabelle- DD1 2009 & DD2 Mar 2012
The Time Has Come- DS Aug 2010
25andhopeful - natural miracle- DD Apr 2012
Claire77 - ???? Jul 2012
Bebehvala - DS Aug 2012
Felicita - DS & DD Sep 2012
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This might be a farewell to comic conventions, at least for a little while. Let's write it and find out.
I've never felt very comfortable on the show floors at cons. For anybody who's never been to one, imagine an aircraft hangar stuffed with rows of tables. At these tables are a mix of creators – some you've never heard of, some so beloved you can't believe you're in the same room – and people selling comics and comics-adjacent merchandise – t-shirts, prints, hand-knitted toys, Back to the Future-themed vinyls.
So, in theory, you can go up to the person who wrote or drew or coloured that one comic that broke your heart last summer, and tell them how it helped you grow as a person while they put their signature on the front of it. In practice – at least for someone who is: a) a bit socially anxious and b) reads pretty much all of their comics digitally – you end up awkwardly standing over their table going 'hey... um... I think you're cool?' and then running away Zoidberg-style.
Which is how I met Jamie McKelvie and Kieron Gillen at a Birmingham Comics Festival, enough years ago that I don't want to actually check the date lest my body erode with sheer age and blow away in the wind.
I followed them from event to event for a while, until I realised the whole comic-con thing might not be for me. I remember being at Bristol Comics Expo, dropping by their table for the fifth time that day and over-sharing (as usual) that, if I felt out of place even in at a comics convention, where the hell would I ever fit in? So I gave up on comics events.
|Me and my boo.
It was a revelation, not only because it forged one of the most important friendships in my life, or even because Tim that weekend introduced me to beef brisket, an eating experience I would chase for many years afterwards. But because, for the first time in my life, I unreservedly enjoyed a comic con.
Let's be clear: Thought Bubble uses the same basic format of tables in a hangar. And I still feel just as awkward at the tables of people whose work I love, stammering that fact in their faces down at waist-level. But it also has a dancefloor.
|This year's dancefloor, courtesy of Reece Lipman. The file name informs me it wasn't even midnight yet.
I might not be the world's most comfortable talker, but drinking and dancing? That is somewhere I feel right at home, especially when said dancing is to the likes of Kenickie (thx KG). I've been to the past six Thought Bubbles, and that dancefloor is a large part of it. I have a pleasant enough day, mumbling praise at my favourite creators and sitting in some excellent and occasionally enlightening panels, but the whole time I am like J-Lo. Waiting for tonight.
That lack of inhibitions, especially with Tim as my drift-compatible dance partner, means we've been first to the 'floor a few times over the years, and felt a small warming nugget of responsibility when it eventually catches light.
|Early doors on this year's dancefloor.
Our group has swollen, from that initial two into something more closely resembling Blazin' Squad. I have friends I know entirely through Thought Bubble, faces and names I know solely from previous years' parties. Every year the number grows – not least thanks to Boy King of ThoBubs Adlai McCook, seen in the below picture receiving his rightful worship.
|Picture nicked off'f Al Kennedy's Twitter. Sorry Al
All this means expectations, and expectations can be dashed. There's the fear that traditions can ossify into a mandated ticklist.
So I went into this year's Thought Bubble having decided it would be my last, at least for a little while. Coincidentally, but also not entirely coincidentally, Jamie and Kieron (and Al, it turns out) had declared it also would be their last time DJing.
So my heart was especially big this year, and ThoBubs filled it. The feels runneth over.
|Picture feat., and nicked from, the Whatnot Tree collective
Then, on the other end of the spectrum, you have Speed Cock.
The culmination of the Silence to Astonish panel – a sort of surrealist comics chat show hosted by a man in a homemade Galactus helmet and a rubbery-faced werewolf – Speed Cock is the ancient competition of drawing as many penises on a whiteboard within one minute as possible.
With its own theme tune. There wasn't a dry eye in the house.
|The panel in question, this year starring 'temporary Ryan North' Adlai McCook
Then again, when else are you going to get the opportunity to dance through a tangle of tables, a tray of ribs in hand, knowing that if the next song is a major banger you're going to have to drop the food to the floor and sprint to the 'floor?
Besides, the audio problems also led to one of the night's most magical moments. Faced with a minute of technical-difficulties silence, Kieron cast around for a song people might be able to sing without any accompaniment.
"...Every now and then I get a little bit nervous, that the best of all the years have gone by."
"Every now and then I get a little bit terrified, and then I see the look in your eyes."
"Every now and then I fall apart!"
And you look around the dancefloor, and you think about all the horror that's been going on in comics of late, horror that like, much of 2016, you can summarise as cishet white men being awful to everyone else. And you look at the faces, as many women as men, everyone letting their freak flag fly, screaming the lyrics to a Bonnie Tyler song no of them can hear, and you think: No, this is comics.
And then you step back from the dancefloor, partly because this song isn't one you've got the moves for but mostly because the last run of Robyn/CRJ/Taylor Swift has left you with no shake remaining in your ass. And you put your arm around Adlai, and the two of you get a bit teary over what's unfolding in front of you, and that this might never happen again.
And then Modern Love comes on and you rush back to the dancefloor, and the circle of friends you left three songs ago is still there only it's somehow grown even bigger, and you dance and you shout the words and know that there is some corner of Leeds that will be forever dancing, forever the very best of geekdom, forever ThoBubs.


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March 2014- Russia takes over the Crimea because they want to protect their naval fleet, and their hidden stores of vodka.
June 2014- Russia begins infiltration and takeover of eastern Ukraine, wanting to 'protect the Russians living there' who invaded centuries ago. Continue Reading


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TWO Yorkshire police forces are among eight nationally which have been told by inspectors they need to improve.
South Yorkshire Police and Humberside Police have been judged as requiring improvement in the latest efficiency inspection by Her Majesty's Inspectorate of Constabulary.
North Yorkshire and West Yorkshire were both deemed to be "good" by inspectors who examined the extent to which forces keep people safe and reduce crime.
Hillsborough, Rotherham, Orgreave and the Rhino Whip Affair: Five police scandals in South Yorkshire
In the case of Humberside - which last year was the only force in the country to be judged "inadequate" - Inspector Mike Cunningham said he was "disappointed" that there were not enough officers to attend emergencies quickly.
This meant sometimes the service provided to the public was sometimes sub-standard.
South Yorkshire Police - which last year was also rated as "requires improvement" - had "a limited understanding" of how to prevent crime taking place, Mr Cunningham said.
He added: "The force's limited understanding of current and future demand, and of workforce capability, is adversely affecting the quality of services it currently provides."
The force was addressing the issues, he said, and inspectors would closely monitor its progress.
Humberside Police and Crime Commissioner Keith Hunter said he was pleased Humberside had improved from last year's "inadequate" rating. He said he had been working with Chief Constable Justine Curran to address the issues.
He said: "This report is a first small step, there is still some way to go but I do think the Force are planting the right seeds and my assessment into the future will be based on how they cultivate those."
Ms Curran said staff "have worked really hard to achieve these improvements and we're not finished yet.
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South Yorkshire's Police and Crime Commissioner Dr Alan Billings said the report's findings confirmed the priorities the force has been working to since a peer review conducted by the College of Policing earlier this year.
New chief constable Stephen Watson had a "clear brief" to address issues including neighbourhood policing and better planning for future demand.


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Ballet San Jose is rolling out the red carpet for families at its Saturday matinee of "Don Quixote" at the Center for the Performing Arts.
The show is already a family-friendly "starter ballet" for kids, spokesman Lee Kopp points out, but there'll be a lot of activities aimed at the younger audience members starting in the lobby area at 12:30 p.m., an hour before the curtain goes up.
The activities include arts and crafts, story-time with a ballerina and an introductory class with a faculty member of the Ballet San Jose School (each family gets to take home a "ballet workbook," too.) While ticket buyers will be able to take part in all that fun, Ballet San Jose has also given away about 800 tickets to students and families from its partner schools for this season: Empire Gardens, Grant Academy and Lowell elementary schools. Big round of applause to the Sharks Foundation and the Comerica Charitable Foundation for their sponsorships.
If you need more info, get it at www.balletsj.org.
CAMPBELL COUPLE: Valentine's Day tales are often told of young love, but there's nothing wrong with love that's a little more mature. Take Ed and Chrystie DeSoto, who own the Olive Bar in downtown Campbell and have been married 48 years. You might think that after all that time, a couple might be happy to get some alone time, but not these two. They opened the shop — which sells premium olive oils, coconut oil, balsamic vinegars and more — six years ago when Ed was 70 and have run it together ever since.
Ed tends to take the lead entertaining customers in the shop, but Chrystie's no wallflower. She founded the Assistance League of Los Gatos-Saratoga back in 2000.
TEDDY TREATMENT: More than two dozen employees at Kaiser Permanente Santa Clara — including caregivers, nurses, administrators and physicians — spent their lunch break Tuesday stuffing teddy bears. Kaiser spokesman Karl Sonkin tells me the "stuffing bee" is part of the hospital's employee wellness program because it gives the workers an activity to do (not to mention a chance to catch up with co-workers).
And the completed bears are sent to Kaiser Santa Clara's pediatrics department where they're distributed to kids with cancer and other illnesses on Valentine's Day.
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Pleasure is important in life, the sexy and erotic times with a women or man can be the most intermit times ever and you have to enjoy the time and pleasure that will be received. These are my experiences and I've learnt from these, my experiences have made me the person I am now and that's damn good. The passion you can have for one person is unreal and I love it!
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Product Description
The New York Times bestselling Throne of Glass series comes alive in this exquisite new colouring book, featuring 46 pieces of original art.
For the first time, fans of Sarah J. Maas's sweeping New York Times bestselling Throne of Glass saga can experience the vivid imagery of her expansive world. Celaena battling the ridderak in the catacombs, Chaol in the gardens of the glass castle, Manon riding her wyvern through the Crossing, and many other favourite moments, characters and objects come to life as readers explore the vibrantly detailed realm of Throne of Glass. Stunning original black and white drawings will bring fans deeper into the series than ever before - making this a must-have companion to Sarah J. Maas's beloved books.
REVIEW SNAPSHOT®by PowerReviews
Reviewed by 4 customers
Comments about The Throne of Glass Colouring Book:
Some pages are clear and well-drawn, easy to colour successfully, others are sketchy and/or 'black' making it difficult. It would be a good one for colouring-in freaks and Game of Thrones nuts.
Best Uses
Comments about The Throne of Glass Colouring Book:
This coloring book is so amazing and beautiful! It's so great to be able to have this visual experience of Sarah J. Mass's books and to see my favorite characters on paper. Every picture is so detailed and original.
Comments about The Throne of Glass Colouring Book:
Comments about The Throne of Glass Colouring Book:
A Good Reads Choice Award winner for Best Young Adult Fantasy/Sci-Fi for 2015 * Praise for Queen of Shadows *
Series: Throne of Glass
Audience: Children
Format: Paperback
Language: English
Number Of Pages: 96
Published: 6th September 2016
Publisher: Bloomsbury Publishing
Country of Publication: GB
Dimensions (cm): 25.5 x 25.6 x 1.1
Weight (kg): 0.55
Edition Number: 1


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Mihaylo Career Services
Career & Concentration Exploration
Video and Additional Resources
Mihaylo HIRE and Success Stories
Mihaylo Career Services
A successful interview requires preparation and practice. Please download The Ultimate Interviewing Guide (PDF) for key strategies and a sampling of interview questions – both common and tricky ones!
|Want to practice online? The CSUF Career Center offers Interview Stream, a virtual mock interview system that allows you to record and view your responses to common interview questions.
Ready for some in-person practice? Schedule an appointment! Be sure to provide us with the job description you will be interviewing for so we can customize your interview!
Your professional image helps to make a critical first impression with employers. Check out our Professional Attire Guidelines (PDF) to help you sort through business professional, business casual, and what's just not at all appropriate for business settings.
Produced by the Mihaylo College of Business and Economics at California State University,
800 N. State College Blvd., Fullerton, CA 92831-3599
Phone: 657-278-4652 | E-mail: firstname.lastname@example.com | Maps and Directions.
Contact the web administrator for comments or problems with the website. © 2017, All rights reserved.
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12 5-HOUR ENERGY DRINK 2 FL OZ Lemon-Lime flavor
Sold for:
Start Free Trial
or Sign In to see what it's worth.
- Sold Date:
- Source: eBay
About 5-Hour Energy Drink Feel bright, alert and focused
Whendescribing the 5-Hour Energy feeling, some people say its like the suncoming up in my head. Thats because when youre feeling groggy and lethargic, 5-Hour Energy wakes up your brain and gets you back to feeling the way you want to feel bright, alert, focused and energetic. What you wont feel is jittery, or crash. Thats because, unlike other energy drinks, 5-Hour Energy doesnt jack you up with sugar, caffeine and herbal stimulants. Instead, its packed with stuff thats good for you B-vitamins, amino acids and enzymes.Drink it in seconds
To get anything out of those canned energy drinks you have to force down a lot of liquid up to 24 ounces for some of them. It takes just seconds to slam down a 2-ounce 5-Hour Energy shot. That means its energizing ingredients get into your system faster.Feel it in minutes
In a few minutes you can feel 5-Hour Energy brushing away the cobwebs and helping you regain the alert, focused feeling you need to get through your day. Canned energy drinks give you a lot of sugar, caffeine and herbal stimulants which can make you feel jittery, shaky or tense. But 5-Hour Energys blend of vitamins, amino acids and enzymes gives you hours of smooth energy.Lasts ... read more


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Recorded Webcast: "The Transformation to S1000D: Best Practices in Legacy Data Conversion"
Converting legacy data to fully compliant S1000D data is a complex and costly process. In this informative webinar, Warren Smith, VP-Technical Publications at CDG, a Boeing Company, will share knowledge gained from practical experience in managing large scale S1000D conversion projects.
To view the webinar, please complete the following form.
Note: Your privacy is very important to us. We will not sell or share your information with third parties.
Read our privacy policy.


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In a Nutshell
- One bathroom
- Balcony or Terrace
- Private parking
- Dishwasher
- Lake view
With one of the most sought after locations in England, Ullswater Boathouse has stunning views over Lake Ullswater from the lounge, balcony, private lake frontage or the decked terrace overlooking the lake. The boathouse is the perfect hideaway, romantic or honeymoon retreat at any time of year with a real sense of escapism as it is tucked away via half a mile lane from the rest of the world.
Imagine waking up to your own private spectacular view over the most romantic lake in England. The Ullswater Far Boathouse is a perfect year round combination of privacy and luxury for a honeymoon hideaway or idyllic retreat for two.
The Ullswater Boathouse offers you a stunning water's edge view of Ullswater lake with a floor to roof glass wall overlooking the lake. Whether you are curled up with a book on a luxurious sofa looking out at white sailboats from the nearby sailing school, or relaxing outside on the balcony at dusk, watching the gold and orange sunset colours reflect off the fells onto the perfectly still water, you will understand why so many visitors think that Ullswater is arguably the most romantic lake in England for "getting away from it all" and "recharging your batteries."
The Ullswater Boathouse enjoys an idyllic secluded location accessed down a tree lined lane to private grounds well hidden behind gates. But Ullswater Far Boathouse has a luxury secret! It is actually located at the far end of the extensive grounds of Leeming Country House Hotel, a luxurious Macdonald Hotel property and restaurant that has been remodeled to a high luxury standard and a wonderful place for weddings and events. This means that just a short stroll away from the boathouse, the restaurant and facilities of the hotel are available to use. If you are exploring by car, just a 10 minute drive around Ullswater, you'll discover the renowned Sharrow Bay Restaurant and Rampsbeck Country House both famous for their spectacular dining experiences with views over Ullswater.
The Ullswater Boathouse has recently been refurbished to a luxury standard for guests to visit any time of the year. It is particularly special as it is a larger boathouse providing ample room for two guests.
The boathouse has electric panel heaters and comprises:
- Entrance hallway.
- Double bedroom with sensual satin and fur throws, full wall of fitted wardrobes housing a personal safe and wall mounted plasma TV.
- Shower room with 'double' shower cubicle, vanity unit and WC.
- Open plan lounge/kitchen/dining area with contemporary style electric fire, wall mounted plasma TV, DVD player, games table, i-Pod dock, desk and full length picture windows giving access to the balcony and stunning views over the lake.
- Dining area
- Kitchen with electric oven and hob, fridge, dishwasher, wine cooler, microwave and tea and coffee facilities.
- All electric, bed linen, towels, dressing gowns and a hair dryer included.
- A complimentary bottle of Champagne on arrival for bookings of 3 nights or more.
- Sorry there is no cot available as this property is not suitable for children.
- Private parking.
- Garden with generous decked area with seating overlooking the lake, private jetty and lake frontage with seating.
PLEASE NOTE Cancellation Protection is available, please ensure this meets your requirements prior to adding to your booking. Spa Treatments in the comfort of your holiday cottage can be added to your holiday reservation. To ensure these are available for your holiday, these must be booked and paid in advance.
To view prices select the no. of nights and then click on your chosen date on the calendar.
Thank you for our very enjoyable stay at the Boathouse. The weather has been atrocious - but the Boathouse is warm, cosy and beautifully designed. Thank you also for our champagne and chocolates - very kind and thoughtful of you. We would love to return soon- preferably when the weather is better!


text: My Avast Antivirus identifies the following every time I attempt to download the GUI: W32.Sality is an entry-point obscuring (EPO) polymorphic file infector. It will infect executable files on local, removable and remote shared drives. The virus also creates a peer-to-peer (P2P) botnet and receives URLs of additional files to download. It then attempts to disable security software. Infection.Apr 30, 2013 Is this a false positive?


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fax view fax(913) 469-8182 Address 11000 King
P.O. Box 25625
Overland Park, Kansas 66225
United States
P.O. Box 25625
Overland Park, Kansas 66225
United States
http://www.paynejones.com Send Email
|Areas of Practice
|1) Corporate Law, 2) Real Estate, 3) Estate Planning, 4) Banking Law, 5) Employee Benefits and 6) Nonprofit and Charitable Organizations
|Fort Hays State University; University of Kansas (
|Most recent firm
|Payne & Jones, Chartered
A. Harrison Barnes is a well-known attorney throughout the United States. As a member of the Malibu community, Harrison is committed to serving the needs of Malibu residents and businesses in legal matters.
Alan Singer is a partner in Morgan Lewis's Securities Practice. Mr. Singer advises companies with regard to a diverse range of corporate and securities matters.


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Artificial evolution aims to create life out of non-living matter
How did non-living matter transition into living organisms? A team is gently rocking a combination of key minerals and organic molecules to see if certain chemical reactions give birth to life. If life emerges "easily" from these conditions, it could be common throughout the universe.Continue Reading


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Explore popular radiologic technologist careers
Please complete the form to download a brochure and speak to an Enrollment Specialist about starting your application.
Radiography is a growing field. From 2014 to 2024, an estimated 250,000 jobs will be created in radiography and MRI combined.* You can learn to lead in this expanding field by earning your radiology degree online. It's increasingly required for a range of jobs in radiology. At ADU, we offer three tracks of our bachelor's in radiology so you can choose your path to advancement.
One in three ADU bachelor's in radiology grads earn more than $75,000 annually.**
As a radiation therapist, you continue to work with patients and pursue a specialized path. As use of MRI and CT simulations expands in radiation therapy, it's essential to keep up with trends, technology, and advanced procedures within these tracks of expertise. That's why many technologists elect to become multi-credentialed and diversify their skills.
A lead MRI technologist's job goes beyond imaging and extends to include management responsibilities. A mastery of the latest technology becomes critical, so you can mentor your team and manage the quality of patient scans. It's a position that blends a seasoned radiologic technologist's experience with a modern leadership mentality.
In a time when the industry is calling for more training, imaging requires techs who can rise to lead. As a radiologic technologist supervisor, you will need organizational skills to answer to your staff's needs. Supervisors typically assist in hiring, training, and reviewing staff technologists. It becomes important to learn management principles and monitor emerging trends to lead effectively, especially as more radiology technology jobs create an influx of new staff.
— Chad R. Hunley, Online Bachelor's in Radiologic Sciences Graduate
You're ready to take your radiography career to the next level. Our radiology degree can help equip your future. How? Learn management principles, with courses in finance, marketing, and organizational behavior. Become multi-credentialed, with focused tracks to pursue new certifications in CT, MRI, or Multi Modality. Each track can help you move forward.
With our radiology degree, you can:
Learn more about how our online bachelor's in radiology can help support your career goals:
*U.S. Bureau of Labor Statistics
**ADU Graduate Outcomes Survey (2013)


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No Square Filler
Related Articles
- EXPEDITIONARY FORCE? McKenna, Pat // Airman;Mar2000, Vol. 44 Issue 3, p46
Describes how a United States Air Force team tackled the 1999 Discovery Channel's Eco-Challenge, the Superbowl of adventure racing, in Argentina. Financial provision; Training of Team Tier One; Disqualification during the race.
- OVERSEAS CONTINGENCY OPERATIONS. LOVE, TERESA G. // Reporter;2014, Vol. 41 Issue 2, p7
The article focuses on the dangers faced by Judge Advocates Generals of the Air Force and U.S. airmen personnel in times of overseas contingency operations. Topics discussed include the deployment of a fiscal law to military personnel, the strict discipline and accountability of military airmen...
- THE CORE VALUES. Myers, Charles R. // Airpower Journal;Spring97, Vol. 11 Issue 1, p38
Explains the United States Air Force core values based on strategies of moral reasoning. Misunderstandings about the core values; Structure of morality and the core values; Purpose of morality and core values; Core values as standards and ideals.
- We are a professional force preparing for combat. Lorber, John G. // Flying Safety;Aug95, Vol. 51 Issue 8, p2
Discusses the `dues' that members of the US Air Force are expected to `pay' to keep the title of a professional air crew member. Physical and mental preparation; Thorough preflight checks; Rapid and accurate reaction to problems encountered during takeoff; Sticking to the briefed air plan;...
- There I was... // Flying Safety;Nov95, Vol. 51 Issue 11, p2
Discusses the flight mission of a United States Air Force copilot in bad weather. Experience related.
- ANGEL THUNDER 10. // Airman;Sep/Oct2010, Vol. 54 Issue 5, p42
Photographs of several service members of the U.S. Air Force who have rendered their services in various missions in the U.S. are presented.
- AirLant/AirPac battle `E' winners. // Naval Aviation News;Jul/Aug94, Vol. 76 Issue 5, p6
Cites the 1993's finest active duty carriers and squadrons in the United States.
- More pilots choose Jettas over fighter jets. Brown, Justin // Christian Science Monitor;10/12/99, Vol. 91 Issue 221, p3
Focuses on how the United States Air Force will push their men to cover for the shortage of pilots.
- Jeppesen approaches: Why can't we just use them? Jones, Kevin // Flying Safety;Jun96, Vol. 52 Issue 6, p20
Discusses the use of Jeppesen approaches by United States Air Force aircrew for the performance of their mission. Scenario to frame the discussion; Points taken from the AFI 11-206 General Flight Rules; Cases where the approach may be allowed; Question of who should review Jeppesen procedures;...


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Fenix International Jobs in Uganda : Fenix Innovations Fellow
Welcome to Jobwebuganda.com. This website helps you to achieve your career dream by linking you to vacancies from Top Companies in Uganda. Job Seekers are also exposed to best articles for career growth and development. Click Here to Subscribe for Job Alerts We strongly advise graduates not to pay money before getting a Job. Report fraudulent jobs to [email protected]
- Company: Fenix International
- Location: Uganda
- State: Kampala, UG
- Job type: Full-Time
- Job category: NGO Jobs in Uganda
Fenix International is seeking a highly motivated and entrepreneurial Fellow with leadership experience to develop and test innovative sales, marketing, distribution and financing strategies, manage new pilots, collect and analyze data, train Fenix trainers and provide general support to the Fenix Business Development and Technical teams. Fellows will report to the East Africa Regional Director and will work directly with our sales and marketing team on the ground to test, refine and scale up new business models, strategies and systems at Fenix.
This position offers an incredible opportunity to work with an elite team of business professionals and engineers and directly contribute to the success of a Silicon Valley startup. Candidates must have a passion for entrepreneurship, renewable energy and sustainable development in Frontier Markets. As a Fenix Fellow, you will be based in Kampala working on critical projects with real and immediate impact and will have the opportunity to do about 30% domestic and regional travel.
Key Responsibilities
- Work with Fenix partners to drive sales and test new innovative marketing, distribution and financing strategies
- Conduct product trainings and train the trainer sessions
- Collect & analyze and report data from new and existing customers and field studies to contribute directly to Fenix product and business development strategy
- Provide general operations support to the business development and technical teams
- 20% of Fellow time is spent on a project Fellows are especially passionate about at Fenix and co-design with Fenix leadership
- Note: Fellowship responsibilities will be slightly varied to account for the unique skills and experience the Fellows bring to the team, as well as their specific interests and career goals. For example, Fellows with engineering experience could spend some time helping to build after-sales services or conducting field studies for new products. Candidates with marketing experience could spend more time developing marketing materials or campaigns for Fenix.
Required Skills & Experience
- Leadership & project management experience; We are looking for entrepreneurial candidates who have started or contributed significantly to a particular project, team or new company and we especially value candidates who have seen projects through from start to finish, from design to scale up phase.
- One year minimum work experience
- Commitment to live and work with Fenix in Uganda for 6-12 months
- Ability to customize and clearly communicate the Fenix value proposition, including quantitative and qualitative benefits to the customer and the consumer, for written and verbal presentations
- Outstanding written and verbal communications skills (English)
- Attention to detail
- Proficiency in Microsoft Word, Excel & Google Apps
- Ability and drive to work independently
- Bachelors degree
Desired Skills
- Education and/or work experience in both East Africa and abroad
- Business level competency in Swahili, Lugandan, or other East African language
How to ApplySubmit your CV and Application online : Click Here
Dont Miss Latest Jobs In Uganda. Subscribe Today. CLICK HERE


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Hometown:Madison, AL
Occupation:Biomedical Science Major at UAB
First Appearance:2016
Favorite food? Mexican
Your favorite Team? UAB Blazers
Favorite album? My Beautiful Dark Twisted Fantasy -Kanye West
Place(s) in Birmingham? The Birmingham Zoo
About Skelton...
Why did you start roller derby?
I had been looking for a fun way to stay in shape and get out stress when I went to watch my aunt play roller derby. It really peaked my interest so I looked into local teams. I've been practicing with TCR since August and I'm really excited for my first season!
Tell us about your other hobbies:
Dancing, netflix, and studying (I know that's lame but... college).
What 3 Fictional Characters Best Describe You?
Jessica Day, Beatrix Kiddo, and Leslie Knope
Name some of your personal heroes!
My mom, Emma Watson, and Beyoncé
If Skelton weren't in Birmingham, Skelton'd be...
in Germany!


text: From a young age we always hear the women in our lives say they need to lose a few pounds or go on a diet. Why are women so obsessed with a number on the scale? Your worth should not be determined by a number. It should be determined by how you feel.


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Join Trike Patrol! Download full-length 21min 44sec movie now!
The brunette lady in the video is very receptive at the horny man's needs. Click to watch her undressing and fingering her lusty cunt, just to please him... Her naked body looks extremely appetizing. Check out the sensual way she sucks cock.
- amadeus
- : 9min 56sec
- : 4 Apr 2013
- Exclusive video


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Before they are cut my birds look like this…
Then sometimes when I cut my birds this happens….
the birds curl up, humidity doesn't help either. So what to do? I can't work with them like this. So I decided to iron them
and then this happens…
Hurray – the birds are now ready to be pinned.
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Red Hat Bugzilla – Bug 8149
FTPD sleep(3) when a client connects that cannot be resolved by DNS
Last modified: 2008-05-01 11:37:53 EDT
This should probably be disabled by default for a modern build. The comment
above the code (ftpd.c line 5841) is dated apr-93. The UNIX GURU's here
note that it was probably put in there to work around a bug in an old
version of BIND, which is no longer a problem.
#undef DNS_TRYAGAIN in config.h.noac
I have a new .spec file and a patch to go along with it if you want.
Changed in 2.6.1-7. Sorry for the delay, our internal package maintainer changed
a couple of times.


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Now, this is my first post, so I am hoping that this works but anyway...
These are some earrings that I made out of sculpey clay and I just love them.
I made them a year ago, so when I was 12, and everytime I wear them people
always say," Are those sumo wrestlers on your ears?"
Ha ha! O so funny. And yes, they are sumo wrestlers. I am not sure where I
came up with the idea for this, but I love how they have little diapers and funny
sumoesque faces!!!
These are the earrings...
This is a close up of one of the sumo wrestlers...
This is me wearings one of the earrings...
I took hundreds of pictures so if anyone would like to see more shots let me know.
I would really appreciate it if anyone could leave comments about these earrings.
I really wanna know if people like them because I want to start selling some of the earrings
that I make now, and I wanna get opinions first.
Enjoy and dont be afraid to leave comments!


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We were already excited to see Eric Church at the Tacoma Dome in March of 2017, but now we can't contain how CRAZY excited we are after seeing his fantastic cover of Leonard Cohen's "Hallelujah".
Church wowed fans with the song at the Red Rock Amphitheatre in Colorado during his two-night stay according to Taste Of Country.
"I'm gonna try something here, this could go bad," the Chief warned the crowd.
He told a story about how the last time he played this venue, as he was pulling out, he could still see the lights beaming on the rocks and "Hallelujah" was playing.
"I swear to God I have not practiced or anything, this was something I put it on my crew about an hour ago, so we'll see."
If the crowd's reaction is anything to go by, Church had nothing to worry about.
Maybe fans will be treated to the song again when the Holdin' My Own Tour makes a stop in WA.


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Sydney Wedding Band - The Experience
Fresh, vibrant, dynamic, exciting and versatile, Sydney cover band The Experience are guaranteed to make your Sydney wedding or event memorable. A band whose collective performance experience is unrivalled, and a 100% satisfaction rating with clients. In demand for Wedding, and Corporate events, and flexible to cater you and your events every need and want.
Can be everything from solo acoustic, duo, power trio, three, four, five and six piece band. World class vocalists. World class musicians.
To enquire about The Experience for your wedding or your next event, click here . We'd love to hear from you! Lets do this!
(Not just in Sydney either, The Experience are well travelled and well performed throughout Australia, if you are having your event outside of Sydney we are still available to make your wedding or event the best ever experience!!!)
Ps. If you are searching locally for where this band is playing search for the Dave White Experience!
had everyone up on the dancefloor...... (Steph & Rhett Cochrane)
Wedding Band
"Thanks, you guys made our day! From the time we booked to the day itself, you were extremely professional and made it so easy. We loved it! "
Andrew & Mary-Ann
"Just wanted to say thank you for playing at our wedding at Cronulla in March. We thought you were awesome and had such a great night, everyone was up dancing the whole night! I will definitely be recommending you to others"
Mark & Lara Rogers
Corporate / Function
Gigs - various Formats
"The quality of Dave's performances whether in major events or the best in local venues is always a very high & professional standard. You never have to worry about giving Dave any show / event as it will always be successful. I handle acts from INXS and major international acts to local musicians. I do seek a very high standard as my clients deserve . Without doubt One of Australia's most accomplished musicians with a reputation that has been earned."
Harry Della - Rock Circuit Promotions


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Found 7 tutors in Fairfield, ID 83327.
Fairfield 83327 · 0 miles from downtown · $50/hour · teaches ACT English - Bible studies
I'm an experienced English teacher who can help children and adults improve their skills in many language areas. I know some German and am beginning to learn Spanish. I have taught Kindergarten through 12th grade...certified
Fairfield 83327 · 0 miles from downtown · $55/hour · teaches ACT Math - algebra 1 -
Hello prospective students and parents. My name is Amanda, or Mrs. P. I currently teach all levels of secondary mathematics as a certified teacher in the Idaho school district where I live.certified
Sun Valley 83354 · 27 miles from 83327 · $60/hour · teaches ADD/ADHD, Computer BasicsGreen Apple rating, member for 9 years and 4 months
Ketchum 83340 · 24 miles from 83327 · $55/hour · teaches ACT Math - ACT Science -
I am currently ski racing professionally for the Sun Valley Ski Education Foundation XC Gold Team. I graduated Middlebury College with a Bachelor of Arts degree in Physics. I have taken many mathematics classes...certified
Ketchum 83340 · 24 miles from 83327 · $35/hour · teaches astronomy - Business - chess -
I graduated from the University of Colorado, Boulder. There, I earned a Bachelor of Language and Arts for International Spanish for the Professions. As I move towards a permanent career, I would like to use my skills...certified
Ketchum 83340 · 24 miles from 83327 · $45/hour · teaches algebra 1 - algebra 2 -
Hello! I grew up in NY and went to school in Florida to study Finance. I worked at Citibank as a currency and commodity trader in both NYC and London. I quit in March 2015 for a lifestyle change.certified
Ketchum 83340 · 24 miles from 83327 · $50/hour · teaches algebra 1 - algebra 2 - Chinese
I am a native Chinese speaker. In 2015 and 2016, I taught a First-Year Chinese course at the University of Michigan to undergraduates for two semesters. I am teaching a Mandarin class part-time in an independent school...certified


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Challenges and opportunities:
Syrian refugees and the Jordanian community.
Jordan is the six highest refugee-hosting country in the world.
Well known are the pictures of Jordan's stunning historical monuments: witnesses of rich and influential ancient empires. Also, the Jordanian hospitality and generous warmth is a known characteristic. The country hosts the second highest number (87) of refugees per 1,000 inhabitants in the world. A tremendous amount of people has flown the neighbouring Syria from chaos, hunger and violence. The Jordanian government has made high efforts to provide help to these refugees, but support to cope with the situation is needed. Since the influx of Syrian refugees also causes economic problems to Jordanians, many of whom are already living below the poverty line.
Integration of Syrian refugees.
Support for local women.
Trauma healing.
Hope Kindergartens
Syrian refugees face incredible challenges as they try to provide a new life for their families. Most refugees have lost at least one family member in the conflict, and many have been imprisoned or tortured. Their children especially show signs of trauma, such as regular nightmares or excessive reactions to triggers. Many of these refugee children have not attended school for more than two years, and about 50% are not attending school presently. Therefore, the Hope Kindergarten were established and are operating to provide a safe space for refugee children to find security, attention, love and care. They are located in Mafraq, since 2013, and Karak, since 2012. The kindergarten are funded by the BMZ and supported by Vision Hope and private donors.
Family Centres
After establishing and successfully running the Hope Kindergartens, Vision Hope experienced requests and suggestions by the families of the children in the kindergartens. Therefore, different pilot projects and workshops took place to see the interest of the local as well as refugee community. In September 2016, Vision Hope started with a project to target the families of Syrian refugee children and local Jordanian families: the Family Centres. The project is funded by the BMZ and located in the same buildings as the kindergartens as afternoon programme. The project volume for Karak and Mafraq amounts to 555,555 Euro. The specific characteristic of the project is the three-component approach to have a high reach. Firstly, an integrative day nursery for school children was established to help them with their needs, for instance help with homework. Secondly, therapeutic life competences programmes for young women between 15 and 25 years old take place. An ergo therapeutic programme for mothers, especially Syrian refugee women and their toddlers, is the third component. The main goal is to offer the beneficiaries the possibility of reaching a higher degree of self-help capability as well as to work on and heal their trauma.


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3DOcean Erlewine Hondo Chiquita Travel Guitar 3D Model 9722559
3D Model \ Music \ Instruments
Future \ Guitar \ Travel \ Erlewine \ Chiquita \ Cinema \ Yellow \ Played \ Mickael
3D Model - Erlewine Hondo Chiquita Travel Guitar 3D Model 9722559 by staiff @ 3DOcean
3D Model \ Music \ Instruments
this is the replica of the yellow Erlewine chiquita travel guitar as seen in the movie Back in the future, played by Marty Mc Fly (Mickael J. Fox).
3D model made in Cinema 4D.
Animated: No; Low-poly: No; Materials: Yes; Rigged: No; Textured: Yes; UV Layout: Yes; 3D File Formats Included: .c4d (cinema 4d), .obj (multi format); Created In: 3ds max 8, cinema 4d r15; Geometry: Polygons; Poly Count: 22888.
Korg M1 Synthesizer; Grays Sports Almanac & Oh Lala Magazines; Georges Mc Fly Sci-Fi Novel Book; BTTF Plutonium Box; Gibson ES-345 Guitar; Bttf Aiwa Walkman; Guardians of the Galaxy Awesome Mix Audio Cassette.
Keywords: 3d, 4d, Erlewine, back, cg, chiquita, cinema, fiction, fly, futur, future, guitar, hondo, instrument, le, marty, mc, model, movie, musical, retour, sci-fi, science, the, to, travel, vers.


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In a story recounted through the daily log of Captain Allan Hope, the sailors aboard the Rita Anne become mesmerized and transformed by a mysterious glowing rock, and only music and books can restore them to normal.
A captain's log records the puzzling transformation of his ship's sailors after a glowing rock from an uncharted island is brought aboard. They turn into apes, insensate to the captain's orders and ``fascinated by the rock.'' A storm nearly scuttles the ship but also breaks the stone's hold over the men, who return to normal--except for an inordinate fondness for bananas. Once again, Van Allsburg voyages into an unknown territory that is mystical and eerie--though his somewhat overblown prose substitutes unsettling obfuscation for dramatic storytelling. His sharp-edged, ultra-realistic paintings are a marvel in their own right, from the otherworldly luminiscence of the ominous island to the deep indigos used to create the stillness of the ship and sea by night to oddly angled, even dizzying perspectives of the ship's hold and mast. All ages. (Oct.)


text: The friendly team at Harvesting Group Property Services have provided my partner and I, constant professional support throughout our tenancy. They continue to exceed our expectations by replying to queries swiftly and completing repairs immediately, by quality tradesman. Their sincerity to help their clients has made every interaction with the agency a pleasant, problem free experience. We will continue renting with Harvesting Rentals, knowing that we are in the best of hands. - TENANTPeta Morley-Buchanan / Caboolture


text:
Advanced Neuropathy Treatment8400 E Prentice Ave Suite 700
Greenwood Village, CO 80111
Dr. Dean Anderson DC
Have you been told there is nothing else that can be done for you?
Please check your spam folder in your email if you do not see the video report right away.
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Oxidative stress may be involved in breast carcinogenesis. Myeloperoxidase (MPO) is an endogenous oxidant enzyme that generates reactive oxygen species (ROS). A single nucleotide polymorphism (SNP) G-463A in the promoter region has been associated with a decrease in risk of breast cancer. We assessed the association between this polymorphism and breast cancer risk in a nested case-control study within the Nurses' Health Study (1269 incident breast cancer cases and 1761 matched controls). We further investigated potential gene-gene and gene-environment interactions. There were no significant associations between MPO or COMT genotypes and risk of breast cancer. However, the combination of a priori hypothesized low-risk genotypes in MPO and COMT genes was associated with a marginally significant decrease in breast cancer risk (OR, 0.28; 95% CI, 0.08–1.00). Dietary intake and plasma antioxidant levels may modify the association between the MPO polymorphism and breast cancer risk. Although the test for departure from multiplicative interaction was not significant, inverse associations with MPO genotype were more pronounced among women who consumed higher amounts of total fruits and vegetables (OR, 0.58; 95% CI, 0.30–1.12); this association was not found among the low-consumption group (OR, 1.11; 95% CI, 0.63–1.96). The relative risk associated with the MPO homozygous variant genotype was 0.44 (95% CI, 0.18–1.09) for women who had the highest level of plasma carotenoids. Results from this study suggest that exogenous and endogenous modulators of oxidative stress may modify the association between the MPO polymorphism and breast cancer risk. Further research is needed to confirm these possible associations.
Increasing evidence suggests that oxidative stress is involved in the pathogenesis of breast cancer [1]. Exposure to endogenous and exogenous oxidant sources generates reactive oxygen species (ROS), including superoxide radicals, hydrogen peroxide, and hydroxyl radicals in vivo. ROS cause oxidative damage to biomolecules such as DNA, proteins, and lipids, and can cause cellular alteration that may lead to tumorigenesis [2, 3]. Meanwhile, multiple antioxidant defenses exist that can neutralize ROS. Oxidative stress occurs when excessive production of ROS overwhelms the antioxidant defense system or when there is a decrease or lack of antioxidant defenses. Fruits and vegetables are rich sources of a number of antioxidants, such as carotenoids, tocopherols, and ascorbic acid. These compounds can decrease oxidative load [4]. ROS are also endogenously generated by enzymes including myeloperoxidase (MPO) and endothelial nitric oxide (NO) synthase (eNOS) [5, 6], or neutralized by enzymes including manganese superoxide dismutase (MnSOD), catalase, and glutathione peroxidase (GPX) [7]. Variability in these enzymes and environmental exposures may determine the level of oxidative stress in the organism and play a role in breast cancer risk.
MPO is a lysosomal enzyme that is present in neutrophils and monocytes to fight against microbial infection [8]. It generates a strong oxidant hypochlorous acid and also activates procarcinogens in tobacco smoke [8, 9]. A single nucleotide polymorphism (SNP) G-463A (rs2333227) has been identified in the promoter region of the MPO gene, with the A variant allele associated with reduced mRNA expression and transcriptional activity due to disruption of the SP1 binding site [10]. This polymorphism has been reported to be associated with cancer risk at several sites [11–16]. For breast cancer, two studies have reported a nonsignificant decrease in breast cancer risk associated with the AA genotype [17, 18]. Another study found no significant association between the MPO G-463A polymorphism and postmenopausal breast cancer risk [19].
MnSOD, catalase, and GPX are major enzymes that neutralize ROS and form the first line of defense against superoxide and hydrogen peroxide [7]. Non-synonymous polymorphisms in the MnSOD (Val16Ala, rs4880) and GPX-1 (Pro198Leu, rs1050450) genes have been shown to reduce their capacity to quench ROS [20–22]. Ultimate levels of cytotoxic ROS may depend upon the balance among activities of MnSOD, GPX, and MPO. Oxidative stress in vivo can also be modulated by enzymes such as catechol-O-methyltransferase (COMT) [23], which catalyzes the addition of a methyl group to reactive catechol estrogens to convert them into stable methyloxyestrogen conjugates [24]. COMT may protect DNA from oxidative damage by preventing quinone formation and redox cycling [25]. A non-synonymous polymorphism in COMT (Val158 Met, rs4680) leads to reduced enzyme activity [26], which is hypothesized to increase breast cancer risk through reduction in protecting DNA damage from ROS and accumulation of estradiol catechol metabolites. Lin et al. reported an interaction between the MPO G-463A and COMT Val158Met polymorphisms on breast cancer risk, with an elevated risk associated with the increasing numbers of high-risk genotypes in both genes among women with longer duration between menarche and first full-term pregnancy [18].
We investigated the association between a polymorphism in the MPO gene and breast cancer risk in the Nurses' Heath Study (NHS). We further evaluated potential gene-gene and gene-environment interactions between the MPO polymorphism and factors hypothesized to modulate oxidative stress, including genetic factors such as polymorphisms in the MnSOD, GPX and COMT genes and environmental factors such as dietary antioxidant intake and plasma antioxidant levels.
We conducted a nested case-control study within the Nurses' Health Study cohort. The Nurses' Health Study was established in 1976, when 121,700 US registered nurses between the ages of 30 and 55 years returned an initial questionnaire on their medical histories and baseline health-related exposures. Updated information has been obtained by questionnaire every 2 years. Incident breast cancer cases were identified through self-report and were confirmed by medical record review. Histopathologic characteristics of breast tumors were obtained from medical records when available. In 1989 and 1990, blood samples were collected from 32,826 (27%) women. Blood samples were returned within 26 hours of being drawn, immediately centrifuged, aliquoted into plasma, red blood cells, and buffy coat components, and stored in liquid nitrogen freezers. Subsequent follow-up has been >98% for this subcohort.
Eligible cases in this study consisted of women with pathologically confirmed incident breast cancer from the subcohort who gave a blood specimen. Cases with a diagnosis after blood collection up to June 1, 2000 with no previously diagnosed cancer except for non-melanoma skin cancer were included. One or two controls were randomly selected among women who gave a blood sample and were free of diagnosed cancer (excluding non-melanoma skin cancer) up to and including the interval in which the case was diagnosed. Controls were matched to cases on year of birth, menopausal status, recent post-menopausal hormone (PMH) use, month of blood return, time of day of blood collection, and fasting status at blood draw. The nested case-control study consists of 1269 incident breast cancer cases and 1761 matched controls.
Information regarding breast cancer risk factors was obtained from the 1976 baseline questionnaire, subsequent biennial follow-up questionnaires, and a questionnaire completed at the time of blood sampling. Menopausal status and use of postmenopausal hormones were assessed at blood draw and updated until date of diagnosis for cases and the equivalent date for matched controls. First-degree family history of breast cancer was ascertained in 1982 and updated in subsequent questionnaires. Information regarding current and past history of cigarette smoking was ascertained in the 1976 questionnaire and updated in subsequent questionnaires [27].
In 1980 a dietary component was added to the prospective follow-up questionnaire. The validity and reliability of the food-frequency questionnaire (FFQ) in the NHS have been described elsewhere [28]. Since 1980, the FFQ has been expanded to include approximately 130 individual food items plus vitamin and mineral supplement use, accounting for over 90% of intake of most major nutrients. This expanded questionnaire was administered to the cohort in 1984, 1986, 1990, 1994, 1998, and 2002. Nutrient intakes were computed by multiplying the frequency of response by the nutrient content of the specific portion sizes. We also asked questions on the use of specific vitamins and brand and type of multivitamins as well as dose and duration of use; vitamin supplement use was updated biennially. Total daily nutrient intakes were calculated by adding the amounts from multivitamins and specific supplements to the intakes from food. Values for nutrients in foods were derived from USDA sources and supplemented with information from manufacturers. Total energy-adjusted dietary nutrient intakes were used in analyses. Food intakes were adjusted for total energy consumption [29]. To reduce within-person variation and represent long-term dietary intake of participants, we modeled breast cancer risk in relation to the cumulative average of dietary intake up to the questionnaire before the diagnosis [30]. Several validation studies in the NHS cohort indicate that nutrient intakes from the FFQ are valid for ranking subjects in diet analyses. In a comparison of the 1986 FFQ with two 1-week diet records, correlations were 0.79 for vitamin A from foods and 0.76 for vitamin C from foods [31]. In other studies, vitamin E and β-carotene intakes from the FFQ predicted plasma levels of α-tocopherol (r = 0.55) [32] and β-carotene (r = 0.31) [33], respectively. Alcohol consumption was based on the 1990 dietary questionnaire; the 1986 questionnaire was used for individuals who did not provide this information on the 1990 questionnaire.
DNA was extracted from buffy coats using Qiagen QIAamp Blood kit (Qiagen, Chatsworth, CA). Genotyping was performed by the 5′ endonuclease assay (TaqMan), using the ABI PRISM 7900HT Sequence Detection System (Applied Biosystems, Foster City, CA), in 384-well format. The MPO -764T>C (rs2243828) SNP was genotyped in place of the -463G>A SNP (rs2333227) because of technical difficulty in genotyping the -463G>A SNP. The genotype concordance between these two SNPs is 100% in Caucasians and other ethnic groups (African American, Hispanic and Pacific Rim) (http://snp500cancer.nci.nih.gov). TaqMan primers and probes were designed using the Primer Express Oligo Design software v2.0 (ABI PRISM). Cases and their matched controls were genotyped at the same time. A random 10% of the samples were inserted to validate genotyping procedures. Laboratory personnel were blinded to case–control status and quality control samples. The concordance for the blinded quality control samples was 100%. Primers, probes, and conditions for genotyping assays are available upon request.
Plasma antioxidant levels (α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein/zeaxanthin, retinol, α-tocopherol, γ-tocopherol) were assessed by reversed-phase high-performance liquid chromatography (HPLC) methods described by El-Sohemy et al. [34]. All case-control pairs were assayed together, with samples ordered randomly within each pair. Plasma quality control samples were interspersed to assess laboratory precision. Laboratory personnel were blinded to case-control status and the identity of replicate samples. Coefficients of variation for the blinded quality control samples in this data set had a median of 7.4% (range 7.1% to 11.0%) [35]. Lutein and zeaxanthin were analyzed together as lutein/zeaxanthin since they were isomers and are not separated by the method used. Total carotenoids score in this analysis were the sum of scores of α-carotene, β-carotene, β-cryptoxanthin, lycopene, and lutein/zeaxanthin. The score for each antioxidant ranged from 1 to 5, representing quintiles of original concentration. Total carotenoids score could range from 5 to 25. Plasma levels of antioxidants were categorized into quartiles based on the batch-specific cut points of control subjects [35].
We used a χ2 test to assess whether the genotypes were in Hardy-Weinberg equilibrium among controls. We performed unconditional and conditional logistic regression analyses and observed consistent results. In order to increase the statistical power in stratified analyses where the matching was broken, we employed unconditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs). In addition to the matching factors (age, menopause status, recent PMH use, fasting status, time and date at blood draw), we controlled in multivariate analyses for the following potential confounders and breast cancer risk factors: body mass index (BMI) at age 18 (kg/m2, continuous), weight gain since age 18 (<5, ≥5 to <20, ≥ 20 kg), age at menarche (<12, 12, 13, >13 years), parity/age at first birth (nulliparous, one to two children/age at first birth ≤ 24 years, one to two children/age at first birth >24 years, more than two children/age at first birth ≤ 24 years, more than two children age at first birth >24 years), family history of a first-degree relative (yes/no), and personal history of benign breast disease (yes/no). Analyses including postmenopausal women were also adjusted for age at menopause (<45, ≥45 to <50, ≥50 to <55, ≥55 years) and duration of postmenopausal hormone use (never, past use <5 years duration, past use ≥ 5 years duration, current use <5 years duration, current use ≥ 5 years duration). In analyses involving plasma antioxidant levels, we also controlled for smoking status (never, <20, ≥20 to <35, ≥35 years duration) and alcohol intake (0, <5, ≥ 5 to <15, ≥ 15 to <30, ≥ 30 g/day).
To test statistical significance of gene-gene or gene-environment interactions, we used a likelihood ratio test (LRT) to compare nested models that included a single multiplicative interaction term to the models with the main effect only. The genotypes in MPO, MnSOD, GPX, and COMT genes and plasma levels of antioxidants were treated as ordinal variables. The cumulative average intakes of fruits and vegetables and specific sources of dietary antioxidants were dichotomized as high versus low based on the medians in controls. All reported p-values are two-sided. We performed all statistical analyses using SAS version 9.1 (SAS Institute, Cary, NC).
The characteristics of the study population have been published previously [36]. Cases and controls had similar mean BMI at blood draw and weight gain since age 18 years. Cases were more likely to have a personal history of benign breast disease and a family history of breast cancer than controls. Approximately 63%, 33%, and 4% of controls had TT, TC, and CC genotypes, respectively, in the MPO gene. The genotype distribution in controls was under Hardy-Weinberg equilibrium (p= 0.99).
The associations between MPO T-764C genotypes and breast cancer risk are shown in Table 1. The CC genotype was associated with a non-significant 17% reduction in breast cancer risk (OR, 0.83; 95% CI, 0.55–1.26), after adjusting for matching factors and other covariates. The OR was 0.66 (95% CI, 0.23–1.94) among premenopausal women, and 0.86 (95% CI, 0.54–1.39) among postmenopausal women (Table 1).
Because enzymes such as COMT, MnSOD and GPX modulate oxidative stress, we investigated the gene-gene interactions between polymorphisms of these genes and MPO genotype on breast cancer risk. There was no association between the COMT Val158Met genotype and breast cancer risk (Table 2), and stratification by menopause status did not change the results (data not shown). Based on a priori hypothesis, we defined the MPO TT genotype and COMT Met/Met genotype as high-risk genotypes. Compared to women with high-risk genotype combination (MPO TT genotype and COMT Met/Met genotype), women with a low-risk genotype combination (MPO CC genotype and COMT Val/Val genotype) had a marginally significant 72% reduction in risk (OR, 0.28; 95% CI, 0.08–1.00), suggesting a combined effect (Table 2). No significant pairwise interactions or significant stratum-specific joint effects were found between the MPO T-764C polymorphism and the MnSOD Val16Ala, GPX-1 Pro198Leu polymorphisms (Supplementary Table 1).
We found no significant gene-diet interaction between the MPO polymorphism and dietary intake on breast cancer risk. However, there was some suggestion that the association between MPO polymorphism and breast cancer was modified by the consumption of fruits and vegetables (Table 3). The CC genotype was associated with non-significant 42% reduction in risk among women who consumed higher amount of fruits and vegetables (OR, 0.58, 95%CI, 0.30–1.12). We did not observe an association between the CC genotype and breast cancer risk among women who consumed lower amount of fruits and vegetables (OR, 1.11; 95% CI, 0.63–1.96). Similar results were observed for fruits and vegetables separately and for sources of specific antioxidants such as carotenoids and Vitamin C (Table 3).
Plasma antioxidant levels may serve as a better marker of bioavailable antioxidants than dietary intake levels. Therefore, we also evaluated the association between the MPO genotype and breast cancer risk according to plasma antioxidant levels. We observed a non-significant 56% reduction in risk (OR, 0.44; 95% CI, 0.18–1.09) for women with the CC genotype in the highest quartile of plasma levels of carotenoids compared with women with the TT genotype in the lowest quartile (Table 4). The association between the MPO genotype and breast cancer risk was not modified by plasma levels of α-tocopherol or γ-tocopherol. No statistically significant interactions were observed between the MPO genotypes and other individual plasma antioxidant levels, including α-carotene, β-carotene, β-cryptoxanthin, lycopene, and lutein/zeaxanthin (data not shown). Since lifestyle factors such as alcohol consumption and smoking contribute to exogenous oxidative stress [37, 38], we also investigated the interaction between these two exposures and the MPO polymorphism. No significant interactions were observed between MPO genotypes and smoking or alcohol consumption on breast cancer risk (Supplementary Table 2).
In this nested case-control study, we observed no significant association between a functional polymorphism in the MPO gene and risk of breast cancer. We observed a tendency towards risk reduction with the MPO variant among women who had high dietary antioxidant intake or high plasma antioxidant levels. We also observed a marginally significant decrease in risk associated with the combination of a priori hypothesized low-risk genotypes of the MPO and COMT genes. No significant interactions between MPO and MnSOD, GPX, smoking, and alcohol consumption were observed in this study.
MPO is a major enzyme involved in generating ROS and plays a role in oxidative stress and DNA damage [8]. A G→A polymorphism at −463 was identified at the SP1 binding site. Piedrafita et al. reported that the A variant allele was associated with decreased mRNA expression and transcription activity due to disruption of the SP1 binding site [39]. The G allele has been associated with increased MPO mRNA and protein levels in myeloid leukemia cells [40]. MPO GA and AA genotypes were associated with reduced MPO activity, and reduced smoking-related DNA adduct levels in bronchoalveolar lavage cells [41]. It is hypothesized that carrying A alleles is associated with decreased risk of breast cancer through reduced MPO activity and ROS production. We found a non-significant inverse association between MPO homozygous variant genotype and breast cancer risk, providing weak support for this biologically plausible hypothesis. This result was consistent with two previous studies, which both reported a decreased breast cancer risk associated with MPO AA genotype [17, 18]. In the Long Island Breast Cancer Project, Ahn et al. observed a non-significant 17% reduction in risk associated with being homozygous for the A allele [17]. Lin et al. found that women with the MPO AA genotype had an OR of 0.64 (95% CI, 0.11–3.76) in a Chinese population [18].
We observed a tendency that the inverse association between MPO genotype and breast cancer risk was more pronounced among premenopausal women, although the power to detect the heterogeneity was limited. Similar results were reported in two previous studies by Ahn et al. and Yang et al. [17, 19]. Several lines of evidence suggested an association between MPO activity and estrogen levels. Intracellular MPO activity in neutrophils was higher in premenopausal women than in postmenopausal women [42], and circulating variation in MPO is dependent on estradiol levels during the menstrual cycle [43]. Reynolds et al. proposed that estrogen might regulate MPO gene expression in a genotype-dependent fashion [44]. The −463 polymorphism site may be a part of estrogen response element [45], and the estrogen receptor may preferentially bind to the G allele more than to the A allele [46]. Our finding supported the potential role of estrogen in the regulation of MPO activity.
COMT plays a critical role in estrogen metabolism in breast tissue [47]. It catalyzes the methylation of reactive catechol estrogens to convert them into stable methyloxyestrogen conjugates [24]. A SNP in codon 158 results in a valine to methionine amino acid substitution, known to alter enzyme thermolability [26] and lower methylation activity [48, 49]. The decrease in COMT activity may increase the accumulation of carcinogenic catechol estrogen [50]. Catechol estrogen can then undergo oxidation to catechol quinones catalyzed by peroxidase and cytochrome p450. A redox cycling between quinones and catechols generates ROS that can cause oxidative damage to DNA and lipids. Such quinones can also react with DNA to form a stable adduct that may lead to breast carcinogenesis [51]. It is conceivable that the genetic polymorphism resulting in a decrease in COMT activity may increase the breast cancer risk. However, epidemiological studies have found inconsistent associations between the COMT Val158 Met polymorphism and breast cancer risk. Two Asian studies have reported a significantly increased risk of breast cancer among women carrying at least one low-activity COMT-L allele (Met allele) compared to non-carriers [52, 53]. On the other hand, several studies failed to observe an association between the COMT-L allele and breast cancer risk [54–58]. A few reports suggest a significant increased risk in premenopausal women [59, 60]. A recent meta-analysis of 8286 cases and 7322 controls reported no evidence of an association between the COMT Val158 Met polymorphism and breast cancer risk [55]. However, multiple variants in related biological pathways may interact to alter risk. Lin et al. reported an elevated breast cancer risk associated with the increasing numbers of high-risk genotypes of MPO and COMT genes in women with a longer duration between menarche and first full-term pregnancy [18]. In our study, we did not observe an association between the COMT Val158Met polymorphism and breast cancer risk in all women or subgroups stratified by menopausal status. We found that the combination of the a priori hypothesized low-risk genotypes in MPO and COMT genes was associated with a marginally significant decrease in breast cancer risk, although the number of cases and controls in the stratum was small. Studies with sufficiently large sample sizes are warranted to confirm this interaction and further elucidate the exact genetic interaction model.
The consumption of fruits and vegetables, specific dietary antioxidants, and plasma antioxidant levels may modify the relationship between MPO genotype and breast cancer risk. The reduced risk associated with MPO genotype was more apparent among women with higher dietary intakes or higher levels of plasma antioxidants, although none of the interactions were statistically significant. This finding was consistent with the study of Ahn et al., which reported an inverse association between the GA or AA genotypes and breast cancer risk among women who consumed higher amount of fruits and vegetables (OR, 0.75; 95% CI, 0.58–0.97) [17]. Fruits and vegetables are rich in antioxidants such as carotenoids, vitamin C, and vitamin E, acting as exogenous modulators of oxidative stress. In addition, carotenoids can prevent DNA damage [61–64]. Our results are consistent with a priori hypothesis that a decrease in ROS level, resulting from neutralization by exogenous antioxidants rich in dietary intakes and reduced ROS production associated with MPO variant genotype, would lead to a decreased risk of breast cancer. Our plasma antioxidant data, which reflect both genetic and dietary variation, are consistent with the results from the dietary data.
The strengths of this study include its nested case-control design, relatively large size, high follow-up rate, prospectively collected dietary data with repeated measurements, and prediagnostic plasma levels of antioxidants. In summary, we observed no significant association between the MPO polymorphism and breast cancer risk in this study. An inverse association was more pronounced among premenopausal women, suggesting the potential role of estrogen in the regulation of MPO activity. Marginal significant decrease in breast cancer risk associated with the combination of the a priori hypothesized low-risk genotypes in MPO and COMT genes, together with the tendency towards risk reduction with the MPO variant among women who had high dietary antioxidant intakes or high plasma antioxidant levels, suggest that exogenous and endogenous modulators of oxidative stress may interact with each other to affect breast cancer risk. Further studies examining more genes (such as catalase, eNOS) in the oxidative pathway, as well as exogenous environmental factors that influence oxidative stress, may be helpful in elucidating the role of oxidative stress in the development of breast cancer.
We thank Dr. Hardeep Ranu, Craig Labadie, and Pati Soule for their genotyping assistance, Carolyn Guo and Karen Corsano for their programming support. We also thank the participants in the Nurses' Health Study for their outstanding dedication and commitment. This work was supported by National Institutes of Health grants CA098233, CA118447, CA065725, USA.
Chunyan He, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Building II, Room 200, Boston, MA 02115, USA, Phone: (617)-432-7092; Fax: (617)-432-1722, e-mail: ude.dravrah.hpsh@ehc.
Rulla M. Tamimi, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Building II, Room 200, Boston, MA 02115, USA. Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Susan E. Hankinson, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Building II, Room 200, Boston, MA 02115, USA. Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
David J. Hunter, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Building II, Room 200, Boston, MA 02115, USA. Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Jiali Han, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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