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Tags: intelius
Robert Siciliano Identity Theft Expert
Danger!! How's that for a blog title that screams fear, uncertainty and doubt!? Fact is Facebook boast 400 million users and is in so many ways seems out of the control of its founder, and is looking dangerous. This is a company that has grown faster than fast and has a (very intelligent) 20 something CEO just out of puberty calling the shots. It seems the amount they (his Board? CIO? ) lets him run at the mouth that privacy is no big deal, shows an immature lack of control over this operation. Any company that wields this much power needs to be checked and balanced.
Their growing pains are publicly played out in numerous lawsuits and visceral rants by every possible pundit (like me) and privacy professional on the block.
Sure when you are that big there will always be someone who wants to take you down. But every week there is a new story about a security breach or a privacy violation. That tells me it's more than growing pains or jealousy. There are serious management problems there resulting in reputation issues for the company and for the user, security issues.
The 3rd party applications in the form of games and quizzes are sharing data that's not meant to be shared. While the user may agree to the terms of service, they aren't reading the fine print. Is it really in Facebook's interest to allow this?
Seems like every 2 weeks they change whatever privacy settings there are and the public gets more pissed off with each change. Why doesn't someone inside this company have a clue what the public wants? What's more obvious is they don't care!
Criminals and scammers set up fake profiles of companies and individuals all day every day. These social media identity theft profiles are designed to get people to provide data for free gift cards or other offers that ultimately allow for financial fraud to occur. Is there no way they can more effectively police this?
Recently, the chat feature was made public. For a period of time users chats were available for anyone to see. They had to shut it down to calm the mess. How the heck does that happen? Don't they have redundancy built in to prevent this?
Ads appearing on Facebook are sanctioned in some way by Facebook and some are malicious. When clicked they can infect your PC. You would think that a private company worth billions would have systems in place to prevent its users from getting hacked via ads placed on their own servers?
So now that I'm done throwing up, protect your identity. Because when it gets hacked on Facebook, don't say I didn't warn you.
Invest in Intelius identity theft protection and prevention. Not all forms of identity theft can be prevented, but identity theft protection services can dramatically reduce your risk. (Disclosures)
Robert Siciliano Identity Theft Speaker discussing Facebook Hackers on CNN.
ROBERT SICILIANO, CEO of IDTheftSecurity.com is fiercely committed to informing, educating, and empowering Americans so they can be protected from violence and crime in the physical and virtual worlds. His "tell it like it is" style is sought after by major media outlets, executives in the C-Suite of leading corporations, meeting planners, and community leaders to get the straight talk they need to stay safe in a world in which physical and virtual crime is commonplace. Siciliano is accessible, real, professional, and ready to weigh in and comment at a moment's notice on breaking news.
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Twitter recently announced its new tool to help with management and monitoring of its users' accounts: the Twitter data dashboard. An article on lifehacker.com details what this new tool will offer. For instance, you will not need to use your real name on Twitter—and I have to admit, this is an odd way to promote the
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Identity Theft Expert Robert Siciliano So maybe you used a public PC to log into your Facebook account and you hit a button that saved your login credentials. Or maybe you received an email from what you thought was Facebook and you plugged in your username and password and got phished. Now someone other than you
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View original photo, by Allan Tannenbaum-Pool / Getty Images.
(Photo Caption): U.S. President Barack Obama waves while standing with other leaders during the Open Government Partnership event at the United Nations September 20 in New York City. The United Nations General Assembly kicks off September 21, with leaders from around the world attending.
Barack Obama joins Open Government Partnership for group photo
I don't know much about diplomatic protocols, but I would guess that waving during the group photo is something to avoid.
From Jim Treacher's DC TRAWLER at the DAILY CALLER:
You know how some people keep saying Obama is a complete narcissist, and maybe not really all that smart?
…to be continued, updated, as more caption variety is located…

subset: commoncrawl


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CF to Offer Bachelor of Science in Nursing
Jan. 13, 2014
The College of Central Florida plans to offer a bachelor's degree in nursing beginning in August 2014 to help meet growing local and national demand for more nurses with higher degrees.
The Florida State Board of Education approved the college's proposal to offer the Bachelor of Science in Nursing in November, and the college believes the Southern Association of Colleges and Schools, its major accrediting agency, will approve its application for degree program expansion this spring.
"We are excited to bring this much-needed degree to our community," said Dr. Mark Paugh, CF vice president of Academic Affairs. "It's something our students and local health care agencies have wanted for a long time. It's going to be a win-win for everyone; students won't have to leave the area to get their BSN, and the cost will be much lower since our upper division tuition is nearly half that of the Florida State University System."
CF estimates that tuition for upper division nursing courses at CF will cost $4,715, which is more than 40 percent less than a student would pay if they earned their degree at a four-year public university such as the University of Florida.
Dr. Barbara Lange, CF dean of Health Sciences, said the appeal of CF's BSN degree is more than convenience and affordability.
"Our nursing program is well-established and more successful than many other state and national programs," said Lange. "Our students' passing rates on the National Council Licensure Examination for Registered Nurses are much higher than state and national averages. In 2012, for example, our passing rate was 96 percent, but the state average was 87 percent and the national average was 90 percent."
The new program will make CF part of a national movement to better educate nurses and meet the Institute of Medicine's recommendation that the number of practicing nurses with baccalaureate degrees increase to 80 percent by 2020. Currently less than 40 percent of all registered nurses nationwide have a bachelor's degree.
The 120-credit hour degree, which will feature both classroom and online classes, is open to students who live in Marion, Citrus and Levy counties. Interested students must attend an online information session before they can apply, and students must attain an active, unencumbered Florida RN license prior to the second semester of upper division nursing courses.
Applications for the inaugural fall 2014 cohort must be submitted by April 15. For information about the programs, contact Laurie Saputo at 352-854-2322, ext. 1586, or Nancy Cintron at 352-854-2322, ext. 1433.


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What was coming out to your mom like?
I was this very theatrical, artistic kid. I hadn't had a girlfriend in the longest time. And I said to myself, when she was up visiting, hearing my lines when I was auditioning for the play of <i>Jeffrey,</i> and I said to myself, if I get this, I'm gonna have to tell her -- she's not getting the hints. So finally I did, and she was like "Oh I didn't know, I didn't know!" She was a little upset, but she also said point blank, "I love you no matter what, you're my son. And I love Tom," my partner that I was with then and that I'm with now. It's turned out wonderful. She's just an amazing person. Because she was not raised to be anything like that. It's interesting how much she has grown from what she was raised to be, and I wanted to celebrate that, because to see that amount of growth from my eyes is really quite wonderful. Prejudice is taught, and until people really know someone who is gay or someone, until it comes on that personal level then you don't really have to deal with it. [What's special about the book is that] although it does have the backdrop of coming out, it really isn't about that. It's really about the relationship between a mother and son, in all different circumstances. It's kind of like an Auntie Mame with a gay, Southern twist. I think it has a lot of universal themes to it that I will apply to a lot of different readers.
Had she known other gay people, before you?
I hate to sound stereotypical, but she had many wonderful hairdressers and men that would come decorate the house for Christmas. But growing up, I had no role models. It wasn't until I did theater that I met people who were gay and had committed lives with someone else.
Are you excited for the new revival of La Cage?
I hope it's a big hit, I love the show. That's one thing about the show, that overture starts, and no matter what you're going to start tapping your foot. It's just such a great score. And it's a great story.
Have you noticed there's a renewed interest going on in musical theater with Glee and the movie musicals?
I'm in love with Glee, just madly in love. I love that a new generation are hearing that kind of music -- they're hearing great voices and they're hearing people really singing. I also love the movie musicals that are coming out -- I love Chicago, and I love Nine. I thought Hairspray was wonderful.
Who's your favorite TV mom?
Donna Reed, she was perfection. I have a thing for Carol Brady—and maybe Greg too.
She Ain't Heavy, She's My Mother is out now from Random House.
Previously > The 22nd Annual Lambda Literary Awards


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Chris Brown was released from a Los Angeles County Jail in the early hours of this morning.
According to E! News, Brown (25) had been in custody since March after he was booted from court-ordered rehab facility for refusing to follow the rules. The troubled singer also violated his probation last year by getting into a fight outside a hotel in Washington D.C., which he admitted to in front of a judge.
On May 9, a judge sentenced the R&B star to a year in county jail; however, Brown was given credit for 234 days, which were a combination of time already served in jail and in the rehab facility.
US Weekly reports that, though Brown was supposed to serve an additional 131 days at the time of his sentencing, it was predicted that he would be released much sooner.
Meanwhile, he's still expected to complete 1,000 hours of community service, submit to random drug testing and undergo counseling. Brown's probation has also been extended through January 23, 2015.
Following his release, Brown took to Twitter to express his relief:
Brown's probation originally stemmed from his assault on ex-girlfriend Rihanna, to which he plead guilty in June of 2009.


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Hi! I hope you're having a great weekend. Before we get to the weekly workout recap, I had to share one of my favorite weekend traditions… egg sandwiches. Nothing is better than waking up, having a couple cups of coffee, and enjoying a delicious egg sandwich.
We usually make ours with a toasted whole grain English muffin, scrambled eggs with crushed red pepper (the secret ingredient):
Trader Joe's smoked gouda (this is probably the best cheese ever)
And bacon! (we switch it up between turkey and regular)
And of course, B gets a slice of bacon (her favorite weekend tradition)
This week in workouts:
Sunday – rest
Monday – one mile treadmill run + circuit workout
Tuesday – rest (does Christmas shopping count?)
Wednesday – Fusion class
Thursday – rest
Friday – Fusion class
Saturday – rest
Not my most inspiring week ever, but every little bit counts!


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The Pact Professional XP Chronograph System
It's a hit or miss proposition to use reloading manuals or manufacturers' claims to determine the velocity of a load in your gun, for the simple reason that the measurements were taken using their gun. Why should you care how fast your loads are going? Because knowing the velocity of your loads in your gun will allow you to refine them for the best possible accuracy at distance, remove the guesswork from holdover and insure optimum bullet performance on game.


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Review: First class service at budget price!
I ordered accessories for my vacuum cleaner, they were a fraction of the price charged by the main dealer, despatched the next day with free delivery! I will recommend this company to my friends , great service!
24 Oct 2015 by Carolyn
View all Reviews


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|Kazakhstan News
A Radioactive Cloud Wafts Over Europe, With Russia as Chief Suspect
High levels of a substance called ruthenium 106 detected over the Continent have prompted concern about a possible cover-up by Moscow.
Can a Giant Science Fair Transform Kazakhstan's Economy?
With Expo 2017, the former Soviet Republic is trying to wean itself from oil and create a new global financial hub.
Russia Reaches Deal for Syria Safe Zones, but Some Rebels Scoff
The top United Nations envoy for Syria said the deal was a "positive step." But some rebels said it left too many loopholes for the government.
'Turkish Trump,' a Hotel Plan and a Tangle of Foreign Ties
President Trump pledged that his business would avoid overseas deals during his tenure. But his company is pursuing a hotel project with a firm with deep foreign connections.
Kazakh Capital, a Post-Soviet Creation, Is Growing Real Roots
In 1993, Kazakhstan's president moved the capital to what is now Astana, blending elements of its Islamic roots with a dose of a personality cult.
Saiga Antelopes Are Struck Again by a Plague in Central Asia
An ancient species that once roamed grasslands with woolly mammoths is dying in great numbers in Mongolia, with harmful factors piling up.
Iran, Russia and Turkey Agree to Enforce Syria Cease-Fire, but Don't Explain How
Neither the Syrian government nor the rebel fighters — who briefly met face to face for the first time in nearly six years of war — signed a pact.
Looking for a Friend in Old Age
At 80, she has spent years alone in her Russian village.
How Trump's Calls to World Leaders Are Upsetting Decades of Diplomacy
President-elect Donald J. Trump has broken with decades of diplomatic practice in freewheeling calls with foreign leaders.
Trump's Breezy Calls to World Leaders Leave Diplomats Aghast
The president-elect's unfiltered exchanges prompted the White House to urge him to seek the State Department's expertise in his encounters with foreign leaders.
You are here: Index World Events


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Houston Astros vs. Kansas City Royals - 4/14/16 MLB Pick, Odds, and Prediction
Kansas City Royals (5-2) at Houston Astros (3-4)
MLB Baseball: Thursday, April 14, 2016 at 8:10 pm (Minute Maid Park)
I Kennedy (1-0) (0.00) vs. D Fister (1-0) (5.40)
The Line: Houston Astros -118 / Kansas City Royals +108 --- Over/Under: 8 See the Latest Odds
The Kansas City Royals look for their second win in as many nights as they face off against the AL West favourites in the Houston Astros in Texas on Thursday night.
The Kansas City Royals are looking as dangerous as ever to start the 2016 MLB season and are playing the part of defending champions quite well as they are 5-2 through their first seven games and have gotten some pretty stellar efforts across the board. It is no secret that the Royals' bullpen is among the league's best and if they can get a lead into the latter stages of a ballgame they are the closest thing to a lock as their gets in pro sports as they have a platoon of nasty pitchers who have a knack for closing out games. The Royals are expected to send newcomer Ian Kennedy to the bump as he looks for his second win of the season as he will go up against Doug FIster who also got a win in his first outing, though carries a 5.40 ERA.
USA TODAY Sports
The Astros have been considered by many to be among a handful of teams in the American League considered as contenders to win the pennant but a modest 3-4 start has a couple of question marks coming to the forefront despite the season being seven games old. Houston has a pretty potent offense and did suffer a loss on the Chase Utley rule but as mentioned we are in the very elementary stages of the season and nobody for better or worse can judge the season so far in such a small sample size. Houston is 31-13 in their last 44 starts against a right handed pitcher and 47-21 in their last 68 home games, while the Royals are 35-16 in their last 51 against the AL West and 20-6 in their last 26 on grass which should set up a very exciting encounter in a potential preview of the ALCS. KC got the best of the Astros last night but I anticipate the tables turning here as the Astros need a confidence boosting victory and should get a better effort out of Fister.


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IG Holdings Inc. and its affiliates have offered to purchase up to 44.1 million shares of Highlands REIT common stock for $0.17 per share. The offer, which constitutes approximately 5.10 percent of the outstanding shares, expires on April 24th. If all shares are tendered, IG Holdings will pay a total of $7.5 million.
Highlands REIT is a non-traded real estate investment trust that was spun-off from InvenTrust Properties Corp. (formerly Inland American Real Estate Trust) in April 2016.
Earlier this year, the board of Highlands REIT approved an estimated per share net asset value of $0.35 per share, as of December 31, 2016. The IG Holdings tender offer price of $0.17 per share is a 51.4 percent discount to the REIT's NAV.
Highlands had approximately 170,000 holders of record owning a total 864.9 million shares, as of November 2, 2016. IG Holdings and its affiliates currently own 1.9 million shares of Highlands REIT.
If shareholders choose to tender their shares, they will be charged a $100 transfer fee.
IG Holdings is controlled by Ira Gaines, who serves as its sole director and holds all executive officer positions. In 1992, he founded Peachtree Partners, a firm focused on investments in distressed assets.
Highlands REIT is a non-traded real estate investment trust that oversees an 18-property portfolio of office, industrial, and retail assets, correctional facilities, and unimproved land.


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Human Polyclonal IDO1 Primary Antibody for ICC, FACS - ABIN1169196
Boasso, Herbeuval, Hardy, Anderson, Dolan, Fuchs, Shearer: HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells. in Blood 2007
Show all 5 Pubmed References
Mouse (Murine) Polyclonal IDO1 Primary Antibody for ICC, IHC - ABIN1169195
Yadav, Burudi, Alirezaei, Flynn, Watry, Lanigan, Fox: IFN-gamma-induced IDO and WRS expression in microglia is differentially regulated by IL-4. in Glia 2007
Show all 4 Pubmed References
Human Monoclonal IDO1 Primary Antibody for FACS - ABIN4896116
Kaltenmeier, Gawanbacht, Beyer, Lindner, Trzaska, van der Merwe, Härter, Grüner, Fabricius, Lotfi, Schwarz, Schütz, Hönig, Schulz, Kern, Bommer, Schrezenmeier, Kirchhoff, Jahrsdörfer: CD4+ T cell-derived IL-21 and deprivation of CD40 signaling favor the in vivo development of granzyme B-expressing regulatory B cells in HIV patients. in Journal of immunology (Baltimore, Md. : 1950) 2015
Show all 2 Pubmed References
Human Polyclonal IDO1 Primary Antibody for IF (cc), IF (p) - ABIN1714836
Fu, Zhang, Song, Sheng, Li, Li, Song, Wang, Chu, Wei: Effect of bone marrow-derived CD11b(+)F4/80 (+) immature dendritic cells on the balance between pro-inflammatory and anti-inflammatory cytokines in DBA/1 mice with collagen-induced arthritis. in Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2014
Show all 2 Pubmed References
Rat (Rattus) Polyclonal IDO1 Primary Antibody for FACS, IHC (p) - ABIN2192173
Hill, Pereira, Chauveau, Zagani, Remy, Tesson, Mazal, Ubillos, Brion, Asghar, Ashgar, Mashreghi, Kotsch, Moffett, Doebis, Seifert, Boczkowski, Osinaga, Anegon: Heme oxygenase-1 inhibits rat and human breast cancer cell proliferation: mutual cross inhibition with indoleamine 2,3-dioxygenase. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005
Human Monoclonal IDO1 Primary Antibody for IHC (p) - ABIN2723259
Puccetti, Fallarino, Italiano, Soubeyran, MacGrogan, Debled, Velasco, Bodet, Eimer, Veldhoen, Prendergast, Platten, Bessede, Guillemin: Accumulation of an endogenous tryptophan-derived metabolite in colorectal and breast cancers. in PLoS ONE 2015
Human Monoclonal IDO1 Primary Antibody for FACS - ABIN4896114
Chimal-Ramírez, Espinoza-Sánchez, Chávez-Sánchez, Arriaga-Pizano, Fuentes-Pananá: Monocyte Differentiation towards Protumor Activity Does Not Correlate with M1 or M2 Phenotypes. in Journal of immunology research 2016
Human Monoclonal IDO1 Primary Antibody for FACS - ABIN4896118
Lood, Tydén, Gullstrand, Klint, Wenglén, Nielsen, Heegaard, Jönsen, Kahn, Bengtsson: Type I interferon-mediated skewing of the serotonin synthesis is associated with severe disease in systemic lupus erythematosus. in PLoS ONE 2015
Mouse (Murine) Monoclonal IDO1 Primary Antibody for FACS, IP - ABIN1043734
Mellor, Munn: IDO expression by dendritic cells: tolerance and tryptophan catabolism. in Nature reviews. Immunology 2004
Differential expression of CD25 (show IL2RA Antibodies) and IDO mRNA with high and low virulence bovine viral diarrhea virus might reflect temporal differences in transcription during the immune response elicited by these viral strains.
IDO may be involved in downregulating immune responses to M. avium subsp. paratuberculosis and other virulent mycobacteria, which may be an example of the pathogen harnessing host immunoregulatory pathways to aid survival.
INDO participates in IFN-gama-induced death of bovine luteal cells, through a mechanism that involves degradation of tryptophan, thereby reducing tryptophan concentrations to a point insufficient to meet luteal cells needs
SIV-infected macaques exhibiting progression to AIDS displayed greater expression of TGF-beta (show TGFB1 Antibodies) and indoleamine 2,3 dioxygenase in CD8 (show CD8A Antibodies)+ T cells from mesentric lymph nodes.
IDO role in cancer immune responses [review]
This study demonstrated that IDO-1 was elevated in the Solid Component and Cyst Fluid of Human Adamantinomatous Craniopharyngioma.
The Binding Mode of N-Hydroxyamidines to Indoleamine 2,3-Dioxygenase 1
Together, these results suggest that RSV infection of MSCs alters their immune regulatory function by upregulating IFN-b and IDO, affecting immune cell proliferation, which may account for the lack of protective RSV immunity and for chronicity of RSV-associated lung diseases such as asthma and COPD (show ARCN1 Antibodies).
Thus, our study provides novel insights into the interaction between a small molecule inhibitor INCB14943 and IDO1 protein. The structural information will facilitate future IDO1 inhibitor design.
The aim of the present study was to clarify the effect of IDO1induced macrophages on the growth of endometrial stromal cells in endometriosis. IDO1 educated-macrophages may facilitate the survival of retrograde endometrial tissues, and be involved in the pathogenesis of endometriosis.
Our results identified FGL2 (show FGL2 Antibodies), GAL (show GAL Antibodies), SEMA4D (show SEMA4D Antibodies), SEMA7A (show SEMA7A Antibodies), and IDO1 as new candidate genes that could be involved in MSCs-mediated immunomodulation. FGL2 (show FGL2 Antibodies), GAL (show GAL Antibodies), SEMA4D (show SEMA4D Antibodies), SEMA7A (show SEMA7A Antibodies), and IDO1 genes appeared to be differentially transcribed in the different MSC (show MSC Antibodies) populations. Moreover, these genes were not similarly modulated following MSCs-exposure to inflammatory signals
IDO mediated conversion of FOXP3 (show FOXP3 Antibodies) -T cells to Tregs predominantly occurs in children with inflammatory bowel disease.
The study confirmed that high IDO expression in pancreatic adenocarcinoma was related to poor prognosis of patients. These findings provided evidence that IDO was involved in pancreatic adenocarcinoma progression and might serve as a relevant therapeutic target.
ver-expression of CTLA4 (show CTLA4 Antibodies) and IDO1 was significantly associated with biochemical recurrence. Our results provide clues on the mechanisms of tumor development and point to potential biomarkers for early detection and treatment for prostate cancer in young men.
Lipopolysaccharide (LPS (show TLR4 Antibodies)) stimulation increased the expression and activity of the immunoregulatory enzyme IDO1 in hepatic stellate cells (HSCs), and LPS (show TLR4 Antibodies)/HSCs stimulated aryl hydrocarbon receptor (AhR (show AHR Antibodies)) signaling in cocultured regulatory T cells.
this study shows that the presence of IFN-alpha (show IFNA Antibodies) at antigen sensitization activates an IDO1/TGF-beta (show TGFB1 Antibodies)-dependent anti-inflammatory program that upon antigenic rechallenge prevents inflammation via plasmacytoid dendritic cells
Across strains, networks depicted a predominance of genes under-expressed in microglia relative to macrophages that may be a precursor for the different response of both cell types to challenges. The detected transcriptome differences enhance the understanding of the role of IDO1 in the microglia transcriptome under unchallenged conditions.
Data show that indoleamine 23-dioxygenase 1 (IDO-1) inhibitors 1-methyl-D-tryptophan was able to alleviate most of the behavioural changes resulting from unpredictable chronic mild stress (UCMS) exposure.
IDO did not play a pivotal role in the suppression of allergic airway inflammation through adipose-derived stem cells, suggesting that it is not the major regulator responsible for suppressing allergic airway inflammation.
These results indicate that Platelet-activating Factor -mediated endotoxin tolerance is initiated via IDO- and JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies)-dependent expression of SOCS3 (show SOCS3 Antibodies).
Aortic Plasmacytoid dendritic cells expressed CCR9 (show CCR9 Antibodies) and indoleamine 2,3-dioxygenase 1 (IDO-1), an enzyme involved in driving the generation of regulatory T cells (Tregs).
Indoleamine-2,3-dioxygenase (IDO) production by Plasmacytoid dendritic cells (pDCs)is necessary to confer suppressive function to T-Cells, Regulatory (Tregs) in experimental autoimmune encephalomyelitis (EAE).
our findings support the hypothesis elevated IDO activity in non-CNS due to virus infections causes pain hypersensitivity
this study shows that IDO overexpression in dendritic cells attenuates acute allograft rejection
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.
indoleamine-pyrrole 2,3 dioxygenase
, indoleamine 2,3-dioxygenase 2
, proto-IDO
, putative indoleamine 2,3-dioxygenase
, indoleamine 2,3-dioxygenase 1
, indolamine 2,3 dioxygenase
, indole 2,3-dioxygenase
, indoleamine-pyrrole 2,3-dioxygenase
, indoleamine 23-dioxygenase


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Everyone Can Travel If They Get Good Information
Traveling might seem to be very complicated, but being prepared can help make the trip much simpler. You will need to have knowledge about traveling, or you may end up wasting money. Use these tips to avoid these common problems.
Aisle seats can allow you to have more options. The window seat provides a view, while the aisle seat lets you have access that is unrestricted to overhead baggage and bathroom access.
Sign up to receive emails for watching travel prices. You can find this handy feature online at many travel-related websites that will alert you to different prices. When your fare drops to a price you determined to be reasonable, you will receive an alert. This saves you from checking every day for the price.
Research before booking anything. Find reviews online about the places you want to go. Ask other people that have traveled there. Doing some research will make you more aware of what can be expected, and will also help you decide what activities to do once you are there.
Extra Security
Have a door stopper to use during your hotel stay. There are times when extra security is a good idea. Put the wedge in and then put on the deadbolt and chain for extra security.
When traveling with a toddler, you have to bring along things that will keep him interested and happy during the trip. Familiar and favorite toys are a great start. You may want to purchase a new toy to keep your little one excited.
When traveling overseas, it is important to know what types of insurance credit card companies offer you. You may be covered if a flight is canceled. Doing a bit of research before leaving is a good idea.
Are you traveling overnight via an airplane? Take some sleeping pills with you. Sleeping on a plane can be difficult due to the uncomfortable seats, the strange atmosphere and the sounds of the aircraft and other passengers. You may want to take a sleeping medicine if you will be on an extended flight, so that you may rest comfortable while flying. Don't take any pills until after the plan has taken off. If there is an issue or delay you would be sleeping in the terminal!
You may end up at a hotel that is far inferior to the Ritz. If the area makes you uncomfortable but there's no other choice, take a rubber doorstop. Make sure you lock door with the chain, and wedge that door stopper in there. It is relatively easy for an intruder to compromise a chain or lock, but it will be almost impossible to get into a room that is secured with a doorstop.
Cookie Sheets
When taking a long trip with kids, take along some cookie sheets. Cookie sheets can provide flat surfaces on which kids can use coloring books or even to play card games. For little ones, try bringing magnetic numbers and letters for educational enjoyment.
Traveling can be both fun and stress free. It is involved in terms of research, asking questions, and packing, but it is worth it in the end to have a great trip. With these tips, you can be wiser when traveling.


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House Of Moves Puts Motion Capture Science To Work For CSI: 3 Dimensions of Murder GameBelievable actions characterize cinematic sequences of new PC title (March 23, 2006)
House of Moves completes motion capture for the new PC game CSI: 3 Dimensions of Murder from Ubisoft
CSI: 3 Dimensions of Murder features five all-new cases that can be solved using the latest forensic science. It is the first installment in the line of CSI game titles to bring the gameplay into a fully 3D space, and gives fans crime scene environments, evidence collection tools and interactions that are more like the hit television show than ever before.
Single- and multiple-person capture was done at House of Moves using its 100-camera array of four mega-pixel, greyscale VICON MX40 motion capture cameras. The production and animation team opted to motion capture actors to guarantee the full range of realistic human motion.
�Especially in our cut scenes and �reconstruction� sequences where you see scenarios of what happened or might have happened, the characters �talk� with their bodies rather than with words,� said David Felton, Production Manager, Telltale Games. �Using motion capture allowed us to have our 3D characters communicate through their actions. It was a nice experience working with House of Moves, who had the knowledge and expertise to get the job done.�
�Full-body motion capture allowed us to record a set of specific believable actions. It was great to have Telltale Games in for the shoot, which utilized our VICON MX40 rig, several actors and a range of props � hand guns, jars, knives, textbooks, garbage bags, etc,� said Scott Gagain, Executive Producer, House of Moves.
About House of Moves
House of Moves provides professional motion capture services, stock 3D data, and custom 3D animation tools for the entertainment industry. With expertise dating back to 1985 and credits ranging from Spider-Man 2 to Titanic, House of Moves has completed hundreds of animation projects, including feature films, electronic games, television commercials, broadcast television series, music videos and on-line character animation/content for the Web. House of Moves� artists, animators, engineers and programmers work with top Hollywood talent and some of the industry's finest production facilities to help capture and integrate dynamic data in a 3D environment. The world�s largest motion capture studio, House of Moves was acquired by leading motion capture developer VICON Motion Systems in 2004.
For more information, call (310) 306-6131 or visit www.moves.com.
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Related Keywords:House Of Moves, Motion Capture, CSI: 3 Dimensions of Murder, VICON, Ubisoft, Telltale Games, VICON MX40,


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Grant Thornton airport run: Firms are in the running to win lifesaving technology
Defibrillator manufacturer Heartsine has donated one of it pieces of life-saving equipment to the winners of a run at Belfast City Airport on Wednesday, June 24, organised by business advisory firm Grant Thornton.
Richard Gillan, partner in charge at Grant Thornton, said that 13% of all workplace deaths were due to sudden cardiac arrest - around 100 people every week.
But he said many of those deaths could have been avoided had a defibrillator been used. "The device can increase survival rates from less than 5% without a defibrillator to more than 75% with prompt defibrillation."
"It is estimated less than half of businesses in the UK have a defibrillator on the premises, yet all will have a fire extinguisher as it is a legal requirement. This is very worrying when the number of fire fatalities in the UK workplace totalled 17 last year (2013/2014), a figure dwarfed by the weekly SCA fatality figures." Mr Gillan said the firm put substantial emphasis on being a responsible employer - which including having a defibrillator, particularly as sudden cardiac arrest can hit anyone of any gender or age.
He added: "Considering there will be more than 100 local companies, and 500 runners in total, descending on the runway at George Best Belfast City Airport later this month, we are delighted HeartSine Technologies has donated one of its lifesaving devices to protect participants on the night."
The winning team of the race will receive the defibrillator to install in its own office or to donate. Mr Gillan added: "Having already entered a corporate team for the race and with the donation of a defibrillator, this is a great example of local companies working together, which is something we are keen to promote through the race."
Updates for the Grant Thornton Runway Run, which is supported by the Belfast Telegraph, can be found on Twitter by following @GrantThorntonNI or using the official event hashtag: #GTRunwayRun
Belfast Telegraph


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- Description
More Information
Kelp & Nori Seaweed Krispies Mix
The Saile Kelp & Nori Seaweed Krispies Mix is a simple and delicious Food mix that harnesses the benefits of wild Atlantic seaweed and pure organic ingredients, such as puffed brown Rice, dried fruit, Nuts, and dark Chocolate.
- 150g.
- Vegan.
- A umami sensation!
- With rich dark chocolate.
- A simple & delicious food mix.
- Contains puffed brown rice, nuts & dried fruit.
As there is no distinct taste of ground Walnuts, Almonds or the seaweed contained in each krispie, these delicious dark chocolate Snacks are the perfect healthier option for children with a sweet tooth!
- Summary
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Alternative Saile Mixes Available:
- Directions of use
The Saile Kelp & Nori Seaweed Krispies Mix makes up in to 4-6 portions depending on size (can be cut in to bars or squares).
- Ingredients
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Organic Puffed Brown Rice, Organic Walnuts, Organic Raisins, Organic Flaked Almonds, Organic Chopped Dates, Organic Sugar Kelp & Nori Seaweeds, 60% Organic Chocolate.
- Delivery
Orders under £50:
Royal Mail: £3.49 delivery within 1-3 working days from dispatch.
Orders over £50:
Free delivery within 1-3 working days from dispatch.
UK delivery charges are charged at a flat rate. This means regardless of what you order, they will not increase. Standard UK £3.49 delivery is sent using the Royal Mail Standard service and your order will be delivered within 1-3 days. We use UK Mail and Royal Mail Tracked for our next day delivery service and this will require a signature upon delivery. Free UK delivery is sent either by Royal Mail Tracked or via UK Mail. For international deliveries please check our page.


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Norway 69° North – Hamperokken 50km – Tromsdalstinden 28km – Blamann Vertical Km
"We cannot think of a better place than the mountains of Tromsø for a skyrace: a place to run between the sky and the earth and to feel freedom. You will run technical ridges with the fjords on every side, and cross grass valleys in true wilderness, while the most iconic and beautiful city Tromso. The course joins the 2 higher summits of the area, Tromsdalstind and Hamperokken, in pure single track and off-trail style "
Tromso SkyRaces comes again for the 3rd edition, following the soul of sky running linking technical summits the participants must have a combination of endurance, speed and mountaineering skills and knowledge.
The route has long and sustained sections of scrambling terrain on Hampeokken ridge, off trail sections on lose rocky parts in Tromsdalstind and off trail forest sections on the lower parts and snow fields on the summits.
Blamann Vertical will take place on Friday 4 august 2017 and Tromso SkyRace (Hampeokken and Tromsdalstind) the 5th August 2017. They will be part of the Vertical and Ultra MiguRun SkyRunner World Series. The event is only suitable for highly experienced competitors and with mountain knowledge.


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Square Neck Chiffon Prom Dress with Beaded Applique Straps
(SKU LF13030775) Read All Reviews
I was literally sparkling on the night of my 18th birthday party with this dramatic flowing green prom dress! The embellishments-appliqués, beads, rhinestone, crystals did the magical work.
Mellisa Morgan from United States
Aug 18, 2013


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Boston, MA (PressExposure) May 08, 2013 -- Holt, who has been a key member of the Emerson Bearing Boston team for 47 years, has been promoted from Inside Sales to Marketing Specialist and will oversee the Wood Products Division.
Holt has comprehensive knowledge of bearings, having begun his career with Emerson Bearing Boston as a part-time warehouse stock assistant when he was a student. After graduating from Boston Trade School of Roxbury, he began working full-time at Emerson Bearing Boston and received hands-on training in fulfillment and sales.
From logs to finished cabinetry, the wood industry spans a variety of bearing requirements. At the logging level heavy duty mounted units and roller chain are essential as the logs are de-limbed and rough processed at the sawmill. The finishing phases requires saws, planers and finishing equipment that use high-speed spindles that work under great stress while maintaining critical tolerances.
Emerson Bearing Boston offers special solutions for the industry including Radial ball bearings with the P53 designation. The Abec 5 precision accommodates high speeds and controlled runout while the C3 internal clearance allows for the stress and heat buildup of high radial loads. Other related products include Ball Bearings, Roller Bearings, Super Precision Bearings, Mounted Units, Linear Motion, Oil Seals and Spherical Bushings.
Bearing Failure Analysis
As part of their customer care, Emerson Bearing Boston offers the unique service of "Bearing Failure Analysis" which helps them determine the cause of bearing failure so that they may prevent future failure and predict reliability. Or, if clients desire to do so, they can utilize the Bearing Failure Analysis program within the Technical Toolbox on the Emerson Bearing website.
To contact Lee Holt in the Wood Products Division, call 1-866-995-8765.
Emerson Bearing offers customers a one-stop shopping experience. With an online product catalog with over 3 million bearings; a vast inventory of bearings; worldwide sourcing; a fixed price program; a knowledgeable staff dedicated to delivering; same day shipping and 24/7 service, Emerson Bearing has become the leading provider of bearings to OEM and MRO markets in the U.S. They are the sister company of Action Bearing and maintain headquarters at 201 Brighton Ave. Boston, MA. For more information, contact 617-782-1400 or toll free, 800-225-4587, email email@example.com or visit http://www.emersonbearing.com.


text: kremlin Archive Is Antivirus Giant Kaspersky Linked to the Kremlin? Posted by VIPRE Security News On July 10, 2017 In Featured Article, Important News Russian-based Kaspersky Labs, one of the world's most prominent developers of antivirus software, has come under intense scrutiny from U.S. intelligence agencies lately, according to a recent report by McClatchy. The reasons for the scrutiny: concerns about Kaspersky's possible ties to Russia's spying apparatus; and the possible Read More


text: Do I Love My Neibour ? Mark 12:31 The second is this: 'Love your neighbor as yourself.' There is no commandment greater than these." What do you think that verse really means ? I am pondering that thought and it comes to mind .... not what we see in the worldly projections of self - love because that can put a person on a path of self distruction and of loneliness and am guessing that is why there is so much drug use and alcohol . ( " I am worth it and I should love myself ") The Truth is according to God's Word : that we were created in the image of God - He loves us and we are precious to Him . So we do not have the need to puff ourselves up by telling ourselves how " loveable we are " . Why does Jesus tell us to love our neibour as ourselves ? I think because we need to give others the same attention and care that we naturally give ourselves. The fact of the matter is not that we hate ourselves nor do we need to love ourselves ( as the world thinks) but to receive Jesus incredible love for us so that we can project that love to others. When we have recieved that love we will not have to compare ourselves to others and we will not focus on ": self " but will become people of God who will love the unlovely . We need to love others with the same love Jesus demonstrated for us .


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Mani Ratnam was spotted at a book fair along with writer Jayamohan very recently.
After news that Sun Pictures have got involved with the movie Ponniyin Selvan, there is no doubt that the director will try his best to ensure a successful hit this time. Keeping in mind that he is determined not to lose anything this time and wants to completely wipe off a bad name fetched by his previous effort Raavanan.
We also hear now, that illustrious Ilayaraja is also to be roped in according to industry insiders.
Moreover there is no dearth of technicians at the same time as none other than the mighty Sun Pictures is concerned with this rumored multi cultured project.
We have to wait still as official announcements have to be made though.One thing is for sure Mani Ratnam is roaring to give his best, for this Tamil epic.
We wish him good luck.


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After whiffing 13 times yesterday against Anibal Sanchez, the Nationals have struck out 270 times through 34 games. That puts them on a pace for 1,286 strikeouts this year, which would rank 14th-most all-time.
That's not quite as extreme as it sounds. First, the Nats have struck out fewer times per game this year than the Pirates and Padres. Strikeouts are simply more prevalent in today's game. All 15 of the top single-season team strikeout totals have come since 2004, and four of those occurred last season. The batter-pitcher confrontation has never been more intense. Hitters today are more willing to wade deep into a count in order to find a pitch to hit out of the park or draw a walk. It doesn't mean they're good, but strikeouts are the cost of doing business in the modern game.
So all those strikeouts, by themselves, are not inherently bad for an offense. Big-strikeout teams can still score runs. The Nationals, obviously, are not scoring many runs, and that's largely because they have not produced the home runs that typically come hand-in-hand with big strikeout totals. Teams sacrifice putting the ball in play in order to put it over the fence more. The Nationals have not achieved the latter half of that all-or-nothing trade.
The 16 teams in baseball history that struck out at least 1,270 times hit an average of 180 home runs, and only one – the 2004 Milwaukee Brewers, who hit 134 and won 67 games – hit less than 152 dingers. The Nationals have hit 24 home runs, which ranks 25th in the majors and puts them on pace for 114.
It's still early, of course, and the Nationals, like all teams, are likely to pick up their home run pace as the air warms and the ball starts carrying more. The loss of Ryan Zimmerman, too, has greatly hurt the Nationals' power numbers (like it's hurt, well, just about everything else).
Boz wrote in his opening day column that the Nationals were going to have an extreme offense, with loads of strikeouts but also more home runs from more spots on the field. So far, the Nationals have fulfilled only the wrong half of that equation.
Anibal Sanchez shut the Nationals down as they lost 8-0 and closed a series win with an unsightly game.
Durham 4, Syracuse 0: Chris Marrero went 0 for 4 with two strikeouts, and he's hitting .243 with a .292 on-base percentage and a .378 slugging percentage. Ross Detwiler allowed four runs in six innings on six hits and three walks, striking out six.
Reading 15, Harrisburg 6: Brad Peacock allowed five runs in 4 1/3 innings on six hits and two walks, striking out six. Archie Gibert went 3 for 4 with two home runs.
Potomac 2, Kinston 1 (11 innings): Destin Hood went 2 for 5 with a double. Danny Rosenbaum allowed one run in seven innings on six hits and a walk, striking out seven.
Hagerstown 12, Lexington 11: Bryce Harper went 2 for 5 with a double and an RBI. He's batting .371/.460/.701 and has a 12-game hitting streak. Blake Kelso went 1 for 3 with a home run and two walks. Michael Taylor went 1 for 3 with a home run and a walk.


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I'm super excited because I'm going to meet Tiffany from Simply Modern Mom pretty soon – she lives in Atlanta area as I do, and I'm getting a little event together (btw, if you are an Atlanta blogger, e-mail me). Anyhoo, Tiffany came up with these great surprise yarn Easter eggs, just for the holiday. The fun part is that you can use them for other holidays, parties, and celebrations – not just Easter.
They don't take long to make, and if you get on the stick you can have several in just a few hours. These eggs are so colorful, they would honestly be great for any party or birthday. Put $100 bills in mine, please. Visit Tiffany's surprise yarn Easter eggs here.


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A high-speed chase across the Lake Pontchartrain Causeway on Saturday night ended with officers firing shots at a man suspected of robbing or trying to rob at least six stores and restaurants in Metairie, Marrero and Kenner in a two-night crime spree, Jefferson Parish Sheriff's Office spokesman Col. John Fortunato said.
The suspect, 26-year-old Ranell Joseph, of Donaldsonville, was not hit by the bullets. He did receive medical attention after crashing into an unoccupied Causeway police car, but the injuries did not appear to be serious, Fortunato said.
The incident started about 11 p.m. Saturday when authorities received a call about a robbery at the Circle K store at 330 Veterans Memorial Blvd. in Metairie.
A man with his face partially covered reportedly reached into his backpack, implying he had a weapon, and demanded money. After taking the cash drawer from the clerk, he fled.
Investigators with the JPSO and local police departments had been looking for a suspect with the same general description following several robberies and attempted robberies Friday night. Area law enforcement agencies had been informed that the suspect drove a gray or black Dodge Challenger, Fortunato said.
About three minutes after the report of the Circle K robbery was received, patrol officer Joe Marcel spotted a gray Dodge Challenger near Veterans and Causeway Boulevard, Fortunato said. He tried to stop the vehicle, but the driver sped away onto the northbound lanes of the Causeway.
Causeway police were notified, and a high-speed chase ensued. Police said the Challenger was driving in excess of 100 mph.
Causeway police asked for assistance from the Mandeville Police Department as the Challenger continued northbound across the bridge.
Near the end of the bridge, the Challenger ran over spike strips that had been placed on the roadway. As the car rolled to a stop, Fortunato said, officers approached Joseph, in the car, with their weapons drawn.
Joseph then accelerated toward the officers, prompting them to fire, Fortunato said. The Challenger finally came to a stop after hitting the unoccupied police car.
Fortunato said Joseph was taken to a hospital for treatment Saturday night. By Sunday afternoon, he was booked in connection with six robberies or attempted robberies, including the Saturday night first-degree robbery of the Circle K.
He was booked with armed robbery of a Burger King at 4933 Veterans Blvd. on Friday night, attempted armed robbery of a Popeyes restaurant at 7100 West Bank Expressway in Marrero on Friday night, attempted simple robbery of a Shell station at 6200 West Bank Expressway in Marrero on Friday night and attempted first-degree robbery at the O'Reilly Auto Parts store at 600 Ames Blvd. in Marrero on Friday night. The three Marrero incidents all occurred between 7:44 p.m. and 8:05 p.m.
The suspect in all of the incidents was described as a black male, 20 to 30 years old, between 5-foot-6 and 5-foot-10 and weighing between 120 and 160 pounds. According to police, a portion of his face was always concealed with something, and he was often described as carrying a black or black and silver handgun.
On Sunday, Kenner police said Joseph also was booked with first-degree robbery of an Exxon station at 3451 Williams Blvd. in Kenner late Friday night. They said he implied he was armed with a weapon and demanded money, getting about $150.
Joseph remained in custody Sunday afternoon. No bail had been set.


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Seeking video editor for one time project
Προϋπολογισμός $250-750 USD
We seek a video editor to edit the full-length recording of our Stevie Awards for Women in Business ceremony into individual acceptance speech videos and then upload them to our YouTube channel.
See last year's presentation clips here: [url removed, login to view]
This project is more video clipping than editing – as you will see from the videos from last year. This shouldn't take an experienced video editor more than a few hours. We need this to be done for all seven of our Stevie Awards ceremonies, so if you do a good job on this first batch you'll have a regular gig for our other six awards programs as well.
We would send you the (approximately) two hour long ceremony video on a hard drive with about 80 – 90 speeches, equating 80-90 videos that you will need to create and post to YouTube.
The video hard drive would be shipped to you on November 21, and the clips posted to YouTube by no later than November 25. We will need the hard drive returned to us.
29 freelancers κάνουν προσφορές με μέσο όρο $600 γι' αυτή τη δουλειά
Hi there! Video production is my profession. I can provide you with a good quality results in a optimally short period of time. These are some of my latest works: [url removed, login to view] All of th Περισσότερα
Greetings! Thank you for being interested in my proposal! In the two decades working in film industry I learned diverse skills from script writing through acting to production on a wide scale. Nowadays I mainly wo Περισσότερα
Hello! My name is Andrey. I work in Adobe After effects, Illustrator and Premiere pro I had experience in: - video editing - logo animation - illustration animation - rotoscoping - compositing You can wa Περισσότερα
Hi! Im a editorand filmmaker from vienna, austria, with more than 15 years of experience in post-production. heres my webside with a lot of stuff to watch: [url removed, login to view] Ive done things like that be Περισσότερα
Hello, I would like to work on your project. I have over 8 years of experience in Adobe After Effects, Adobe Premiere Pro, Sony Vegas Pro and Photoshop, professional software. I offer you good quality and fair price. I Περισσότερα
the rate excludes shipping charges. those may be reimbursed via paypal. About me: * videographer & motion graphic designer with over 10 years experience * skilled with after effects, premiere, audition, Photoshop, il Περισσότερα
Dear Client, I will gladly edit videos for your project, providing the best quality and creativity. Ready to make a free demo to prove you my skills. I want to raise my ratings, so I'm ready to give you the minimal Περισσότερα
Hi There, I'd like to introduce myself for your video editing project. Please check my previous edit films on YouTube channel. Watch my show reel on YouTube [url removed, login to view] Griffon Περισσότερα
Hi, wouldn´t be easier to upload the files on the cloud? Probably google drive or something? Anyway I am a freelance video editor, exeprienced with timeline editing. I have done houndreds of videos, mostly for my em Περισσότερα
Hi! Do you really have to shipping hard drive to editor? Why don't use some cloud service or FTP for example? Some of my works: [url removed, login to view] https://vimeo. Περισσότερα
I'm college graduated AV artist. Will do your job really quickly, and of course will return your hard drive to you :) Here is some of my previous work> [url removed, login to view] Περισσότερα
PICK ME, PICK ME, I'M AWESOME! :D Portfolio: [url removed, login to view] My name is Alex Lascu, I'm 29 and I've been working as an animator, motion graphics artist and video editor for over 5 years. I have Περισσότερα
Hello, I would like to help you out with your project. I really think i'm the right person for this job. I have a great experience in promo production (5 years, I edited over 500 promos for TV series and TV show - Περισσότερα
Video Coaching Services Jeff offers personal and business video coaching services. Marketing yourself through video is essential. In a world of social media sharing, you are doing yourself a disservice if you do not us Περισσότερα
IT experience 15+ years. Individually do this also have team to complete this work in time. Send this work as earliest so that I can finish in time. All your editing and upload work. Good bandwidth and system to work. Περισσότερα
I'm a Venezuelan audiovisual producer whose family and vocational training have converged in originating clear judgement and creative-analytical vision to deal with problems assertively, bringing solutions that favor e Περισσότερα
Dear Sir I am a professional video editor.i done some project in upwork and also i have my own YouTube channel where i uploaded videos after editing. you can check my YouTube channel link in below. if you also needs t Περισσότερα
Hello, thank you for reading my proposal. My name is Livio Ascione and I am a professional film maker and a media specialist. I usually write and produce my videos and I work as an After Effects motion graphics speci Περισσότερα


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Gemvara yellow gold sapphire stud earrings are a classic that you'll wear your whole life. Every pair of our stud earrings is made to order in your choice of gems and precious metals. Most jewelry manufacturers compromise on the quality of the gems they select for earrings, choosing a lower quality than gems for rings. They'll even tell you that quality doesn't matter for earrings because you can't see them while you are wearing them. At Gemvara, we hand select each gem for your yellow gold sapphire stud earrings using the same care and quality standards as we use for our gorgeous gemstone rings. Pairs are perfectly matched for maximum impact. We think classics like yellow gold sapphire stud earrings should be the same investment quality as all your beautiful jewelry, a quality you'll be proud to wear. Sapphire is a very durable gem that wears well over generations. Sapphire is the gem of the soul, a symbol of truth and faith. Sapphire comes in blue, of course, but also pink, yellow and white, which are known as fancy sapphire. Warm buttery 14 karat yellow gold provides the classic golden glow. Gemvara also offers every gold piece in luxurious 18k yellow gold which has a richer color and higher gold content for even more lasting value. Gemvara's fine quality yellow gold sapphire stud earrings are designed to be passed down for generations to come, crafted by hand in the United States.
We can help right away. Chat with a jewelry expert now!


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IAFC seeking $1b for Saudia's Airbus planes
Dubai: International Airfinance Corp Ltd is seeking to raise at least $1 billion (Dh3.67 billion) to buy 18 Airbus Group SE planes that will be leased to Saudi Arabian Airlines, according to three people with knowledge of the plan.
IAFC is exploring options including 12-year amortising loans to pay for 10 A330-300 jets and eight A320 narrow-bodies due for delivery in 2017, the people said, asking not to be identified because the information is private. It's also considering the sale of bonds or its first sukuk next year. A spokeswoman for IAFC did not respond to calls and an email seeking comment. An airline spokesman didn't respond to an email requesting comments.
Saudia, as the carrier is known, is taking delivery of a combined total of 30 Airbus and Boeing aircraft next year. It had ordered 20 A330 regional planes and 30 A320s at the Paris Airshow last year as part of plans to nearly double the fleet to 200 by 2020. The carrier is boosting orders to meet increasing demand for domestic travel and expanding its international route network as competition at home intensifies.
Dubai-based aircraft lessor IAFC has a portfolio of 55 new aircraft with a $4 billion asset value, according to its website.


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GraphicRiver Investment Management Flyer Template 7630573
Photoshop \ Print Template \ Flyers \ Corporate
Included \ Template \ Photoshop \ Grouped \ Management \ Indesign \ Editable
Print Template - Investment Management Flyer Template 7630573 by ArtBeatDesigns @ GraphicRiver
Photoshop \ Print Template \ Flyers \ Corporate
Investment Management Flyer Template
Everything in the files is well organized and grouped. You can easily change the text, pictures and fonts.
- Indesign.
- Editable graphics are embeded
- Character & Paragraph styles are setup
- Photoshop.
- Smart objects with help guides
- Organised and grouped layers
- Print Ready!
- Color profile: CMYK 300 DPI
- Detailed documentation included
- File formats included: PSD, INDD, IDML
- Photos are not included in the file!!!
- Print dimension: A4 (210 mm x 297 mm) with 0.3 mm bleed
- Cutive & Raleway: Download
If you like it, please don't forget to rate.
Thank you!
Layered: Yes; Graphics Files Included: Photoshop PSD, InDesign INDD; Minimum Adobe CS Version: CS4; Print Dimensions: 210x297.
Black & Gold Vip Valentine Flyer Template; St. Patrick's Day Flyer Template; Electro Valentine Flyer Template; Love Factory Flyer Template; Love Sensation Flyer Template; Multipurpose Business Flyer Template Vol.3; Multipurpose Business Bifold Brochure Template.
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beyondBanking - Awards 2012
The third edition of the beyondBanking awards sparked interest and participation. The winners were chosen from over a hundred proposals for the seven categories. A Committee of Experts reviewed the nominations and selected the twenty-one (three per category) with higher quality. Finally, the winner was selected by the public through an online vote.
accessBanking award - promotion of financial inclusion strategies
- Microseguros Popular- Banco Popular (Honduras)
Microseguros Popular is an innovative low-cost social and health protection for low income population. This product improves quality of life and reduce the vulnerability of people at the bottom of the pyramid.
"It is an honor to receive the award from the IDB. Our project wants to lead the way in the social protection and to reduce vulnerability in the base of the pyramid. This is an example of our commitment and responsibility to provide access to more people with limited economic resources through all our products and services."
Luis Fernando Gómez Gómez, general manager, Banco Popular.
More information: www.bancopopular.hn
clearBanking award - strengthening corporate governance, transparency and sustainability reporting
- Informe de sustentabilidad 2011-Banco Galicia y Buenos Aires (Argentina)
To explain the actions on sustainability, Banco Galicia y Buenos Aires prepares an annual Informe de sustentabilidad. This seven edition of the report share with customers, employees, suppliers and all stakeholders the results of his administration. Moreover, is a key tool to manage, measure and evaluate the efforts by establishing the basis for planning future actions.
"The processes we implemented always follow our principles and values, based on ethics and corporate responsibility with the highest standards of transparency. This distinction is for us a recognition of our sustainable management: the Informe of sustentabilidad is a basic tool to pursue this model."
Sergio Grinenco, president, Banco Galicia y Buenos Aires.
More information: http://www.galiciasustentable.com/GaliciaSustentable/Informe_RSC/INFORMES_2011/BG_2011_21.pdf
connectBanking award - dissemination innovative and communication technologies
- Fondo Personal MiFon - Grupo Financiero Banorte (Mexico)
The Fondo Personal MiFon is a simple-opening deposit account in which the user can link his phone to a bank account, and was designed to promote banking in people who have limited or no-access to these services. Banking operations (withdrawals, etc.) are made via short text messages (SMS), which allows them to have all their financial services in the hand.
"This award is a great incentive to redouble efforts and continue with our strong commitment, as a 100% Mexican bank, to bring financial services and increase the opportunities for development of more Mexicans. Congratulations to the IDB to be a showcase of ideas and projects that seek a common goal."
Mayra Hernández, Head of Corporate Responsibility & Sustainability, Grupo Financiero Banorte
More information: www.mifon.mx
equalBanking award – support gender equality and diversity
- Empoderamiento de la mujer empresaria - Banco Azteca, Microfinanciera Azteca y ASMAZ(Mexico, El Salvador, Peru, Guatemala, Brazil)
Empoderamiento de la mujer empresaria is a financing program with high social value that, in addition to credit, empowers women of the base of the pyramid to be a driving force in their families and communities through business training, protection health, financial education and telephone support.
"This award reinforces our commitment as a business group commited with people on the bottom of the pyramid, for whom we have developed a successful business model. We are proud to motivate Mexican women, and thus their families."
Sofía López Mendoza, director, Asociación del Empresario Azteca.
More information: www.empresarioazteca.com.mx/asmaz/que_es/mujer_empresaria.htm
learnBanking award – promotion of financial literacy
- Alianza público-privada para la educación financiera a jóvenes de Costa Rica -BAC Credomatic and Ministry of Public Education of Costa Rica (Costa Rica)
The Programa de Educación Financiera para la Vida is the result of a successful public-private partnership established between BAC Credomatic and the Ministry of Public Education of Costa Rica. After 5 years of working together, was achieved, for the first time and uniquely in the region, an educational reform that includes financial literacy in the school curriculum, a long-term action and sustained impact for many generations of Costa Ricans.
"We are convinced that a better educated population in financial terms achieved better quality of life, enhance their employability and ability to make greater contributions to the development of the region. This award reaffirms our commitment to continue working in this direction, and motivates us to continue providing increasingly significant contributions to improve the quality of life of an increasing number of people."
José Ignacio Cordero, general manager, Credomatic Costa Rica.
More information: www.rscbaccredomatic.com/temas-esenciales/alianzas-edu-financiera.html
planetBanking award – adaption and response to the effects of climate change
- Créditos verdes para las muy pequeñas, pequeñas y medianas empresas - Banco ProCredit (Ecuador)
The línea verde EcoCredit para muy pequeñas, pequeñas y medianas empresas is a response to the will of Banco ProCredit to be a cornerstone of development in the market in which it operates. Since 2011, works in the placement of resources with environmental criteria that ensure that the resulting economic growth is sustainable and with three clear objectives: energy efficiency, renewable energy and environmental measures.
"This award reinforces our commitment with the Ecuatorian society and our customers. Our actions seek Ecuador's economic development and enviromental sustainability from a socially responsible banking model based on solid and ethical principles."
Janet Pacheco, general manager, Banco ProCredit.
More information: www.bancoprocredit.com.ec/index.php/ecocredit
socially responsible/impact investment award – best action in socially responsible and/or impact investment
- Investing in businesses driving social & economic impact - Grassroots Business Fund (Regional)
Grassroots Business Fund is an organization that invests in companies that, through their activities, generate income or savings to thousands of people living at the bottom of the economic pyramid. The customers operate in a variety of industries, from agribusiness to craft production, but their business models always share the economic impact for low-income people.
"It is an honor to be recognized by the IDB for our work in the impact investing area. It is a great motivation for our team to continue our mission of providing capital and advisory services to strengthen companies that are impacting the live of thousands of people at the bottom of the economic pyramid."
Harold Rosen, CEO, Grassroots Business Fund
More information: www.gbfund.org
beyondBanking people's choice award - most popular project
- Fondo Personal MiFon - Grupo Financiero Banorte (Mexico)


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Hearing Aids
My hearing aids are Oticon Epoqs. I got them in 2009. They are digital aids with Bluetooth capability. The Bluetooth is used both between the aids (they communicate with each other to provide a balanced sound to the wearer's brain) and also to work with the Streamer attachment (see below). I've been very happy with these aids so far.
Dry & Store
I bought the Dry & Store Professional from my audiologist and use it nightly. Moisture is deadly for hearing aids and even a little bit can interfere with them working correctly, so it's important to have a good way to dry them out. The Dry & Store products use Dry-Brik dessicant to remove moisture from the aids. The Dry & Store and Dry-Briks are somewhat expensive, but it's worth it to me. (Note: I can see I'm a little behind the times, as they no longer make the Professional model. I'm sure the others work just as well!)
Oticon Streamer
The Streamer is a device that works with some hearing aids to "stream" sound via Bluetooth to the aids. You can pair the Streamer to most cellphones or even bypass the Bluetooth and plug an audio cable into the Streamer and the device you want to use.
|My 2009 photo of the Streamer, the accessories it came with,
and my phone.
My experience with the Streamer has been mostly positive. My only difficulty has been getting in the habit of actually wearing it often. A lot of the time I just don't want an extra accessory. When I do use it, however, I am always impressed by it. The audio quality is great and I hardly miss any sound when it is piped directly to my hearing aid. I can't say for certain but I expect using the Streamer and aids exceeds any headphones or earbuds for the sheer experience of having sound right in your head.
Sonic Alert Alarm Clock
I have had several alarm clocks made by Sonic Alert and have been pretty happy with them all. When I am sleeping without my hearing aids, the only way for me to wake up is for the bed to shake or for someone to wake me up. These alarm clocks come with a bed shaker attachment that can go under the mattress or pillow. I wouldn't be able to wake up without them!
Graco Direct Connect Digital Baby Monitor
This baby monitor has a vibration function as well as a flashing light function to alert you when there is loud sound (i.e. the baby crying). You can clip it onto your clothes so that you can feel the vibration and so that you can move around the house while the baby is in another room.
|The Graco Direct Connect Digital Baby Monitor
My Dad got this baby monitor for me when I was expecting my son and it has been wonderful. It's not too clunky and the child unit is easy to move from room to room (for example, to the nursery when he is in his crib, and the bedroom when he is in his cradle). The parent unit has great quality audio. I actually use the flashing light more than the vibration. It flashes yellow for moderate sounds and red for loud sounds.
Foscam FI8918W Wireless/Wired Pan & Tilt IP/Network Camera
This isn't intended as a baby monitor, but it works really well. It's easy to set up, a nice small size and has a wide range. It has web access so that you can have the monitor feed open on your computer or smartphone, and you can move the camera's angle around remotely. It was not difficult at all for us to find a spot in the nursery where the camera angle can be adjusted to see almost the entire room. Plus I think it's kinda cute!
Web Applications
Amara makes it easy to create subtitles for videos. You can also submit videos for captions to be translated to hundreds of languages. For more information on how to caption your video using Amara, check out my blog post here.
Genetic Testing
23 and Me
|The 23 and Me logo


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IN an ancient tradition dating back to 1700, Roger Cox was carried aloft through the streets of Abingdon.
Last June, Mr Cox was elected Mayor of Ock Street for the sixth year running, and also as the Squire of Abingdon Traditional Morris Dancers.
As part of the ritual, morris dancers deliver ballot papers to all Ock Street residents who then vote for their chosen 'mayor' as a traditional snub to civic authority.
The image of newly-elected Mr Cox being carried through the town is one of 50 photos in a new show highlighting folklore, myths and traditions from across the country.
The exhibition at the Oxfordshire Museum in Woodstock features the photos of Sara Hannant, and is entitled Mummers, Maypoles and Milkmaids: A Journey Through the English Ritual Year.
Ms Hannant, from London, said: "Oxfordshire has a lot of fascinating traditions and I'm delighted the museum in Woodstock is staging the exhibition."
The photos went on show at the Park Street venue on Saturday and the exhibition runs until July 28.
Museum director Carol Anderson said: "With May Morning celebrations in Oxford tomorrow, it's a great time to put this on.
"People will be able to find out more about local traditions, and traditions in other parts of the country.
"As well as the photos, visitors can see a Maypole from Cogges Manor and costumes worn by Abingdon Morris men.
"Woodstock has its own tradition of a Mock Mayor and we have a Mock Mayor costume dating back to the 18th century.
"Sara's photos are very lively and she has captured different traditions at festivals around the country."
Lorraine Horne, audience development officer at the museum, added: "These photographs show a quintessential English life that is steeped in tradition and mystery.
"All of the pictures are compelling and give a real sense of the excitement of costumed processions, traditional dances and mumming plays that are held in rural and urban locations throughout the country."
Other photos show Maypole dancers at the Jack-in-the-Green Festival in Hastings, Sussex, the Tree of Fire celebration to mark the beginning of spring in Marsden, Yorkshire, and flaming tar barrels at a ceremony in Lewes, Sussex.
During the Woodstock Carnival on Saturday, June 22, Ms Hannant will be at the museum.
An activity session on the day will give visitors the chance to make a mask to wear in the carnival procession.
The museum is open from 10am to 5pm, Tuesday to Saturday, and from 2pm to 5pm on Sunday.
lFor more exhibition details, go to the website sarahannant.com


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A Work in Progress Theatre Company's Resident Actors Present Monologues that Matter at Hotel RL. Three actors come together to celebrate the ground breaking monologues that changed the theatrical game for generations,
amongst gender, orientation and race. Join us as we celebrate playwrights that used their talents to bring awareness to circumstances that inspired change within our global community. Come enjoy an evening with these talented actors as they perform and discuss the great classics.
A Work In Progress Theatre Company is a Baltimore based theatre ensemble, designed to assist in the advancement and development of new plays, by playwrights who exhibit extreme potential and determination. By presenting new works to a participating audience of analytical thinkers and theatre professionals offering constructive feedback, we create a safe and effective environment for creative and professional growth.


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Bound. Donna Jo Napoli. Setting.
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Donna Jo Napoli
This story takes place during the Ming Dynasty. There was a girl called Xing Xing, who lived with her stepmother and her stepsister. During the Ming Dynasty all the girls had to have their feet bound, the smaller the better. This was because if your feet were small enough to put in a man's hand, you would get a better chance to marry a man that had a lot of money and power. Also, during the Ming Dynasty bound feet were very fashionable, but Xing Xing was one of the very exceptional girls who did not have her feet bound.
Xing Xing was the main character from the book. She was a really nice person, but unlike the other girls she didn't have her feet bound her because her dad didn't want his daughters to do that. However, a few years later Xing Xing's dad died. After that her stepmother started to have Wei Ping's feet bound. Wei Ping was Xing Xing's half sister. Stepmother wanted her own daughter, Wei Ping, to marry a wealthy man and have a good life. Since Xing Xing didn't have her feet bound, she had to do all the chores at home.
Wei Ping was Xing Xing's stepsister,and she was like all the other girls and got her feet bound. She was going to marry a man soon. But unlike Xing Xing, she was a selfish and mean person. She laughed at Xing Xing all the time because she didn't have her feet bound, and said no one wanted to marry her.
Xing Xing's stepmother was not a fair person, and she made Xing Xing do all the hard work at home. As we know Wei Ping was her own daughter so she loved her much more than Xing Xing.
Master Tangwas a really good friend with Xing Xing's father. He was an artist, and he painted a lot of good works. Also, when Xing Xing was young, she learned some of the traditional Chinese art skills from Master Tang. Xing Xing was good at these, and also master Tang really liked her. Another reason that Master Tang really liked Xing Xing wasbecause she was a really nice and reliable person.
Xing Xing and Wei Ping are stepsisters, so Wei Ping doesn't like her. When Xing Xing is trying to wash Wei Ping's feet, the feet oozed a foul—smelling yellow liquid that seemed to drain away her energy. Meat brings energy, so Stepmother tells her to get some meat for Wei Ping. Stepmother is being so mean to Xing Xing because when Xing Xing's dad died Xing Xing was the person that was with him, and he didn't want Stepmother. So Stepmotheris jealous of Xing Xing, and that is one of the reasons why she hates Xing Xing so much.


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A thug who attacked a man in a Chesterfield town centre bar is due to be sentenced.
Chesterfield magistrates' court heard on Monday how Scott Colley, 36, of Spital Lane, Chesterfield, punched Luke Slater after he tried to break up a disagreement between his friend and Colley in the Back to the 90s Bar.
Becky Allsop, prosecuting, said Luke Slater's friend was talking to door staff when the defendant told him to shut up or he would 'take him round town' and Mr Slater's friend was heard to say, "I bet you a tenner you don't".
As Mr Slater tried to separate the two, Colley caught Mr Slater with a fist, according to Mrs Allsop. Colley pleaded guilty to assault after the attack in July.
Elizabeth Roley, defending, said Colley started with the intention of defending himself from an anticipated attack. Magistrates adjourned the case to October 17 to consider a probation report.


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Early History of Middle Tennessee
Early History of Middle Tennessee by Edward Albright originally published in 1909 is a must have resource for anyone whose family is originally from Tennessee, or for anyone with a passion for Tennessee history.
Mr. Albright's own words from his preface:
"The history of Tennessee, and especially that of our own section of the State, was long sadly neglected, and it is now with the greatest difficulty that many of the isolated facts of tradition may be woven into a continuous thread of history. The failure of preceding generations to gather and record, first-handed, many of the stirring events of early times in the Cumberland Valley from those who participated in them, has increased the task of the historical writer of today.
Only one other attempt has been made to write a history of Middle Tennessee and that was by Col. A. W. Putnam, of Nashville, in 1859. From this work I have gathered much valuable information as well as from Carr's Early Times, the histories of the State written by Judge Haywood, Dr. Ramsey, Mr. Phelan, Prof. McGee, Garrett and Goodpasture, and others. I am also indebted to Imlay's Historical Works, Roosevelt's Winning of the West, and Washington Irving's account of Spanish travels.
Much of the latter-day traditions extant in both Sumner and Davidson Counties has been collected and harmonized and to the many sources from which this has been gathered I acknowledge myself indebted. Especially do I desire to express thanks to Dr. J. H. McNeilly, of Nashville, Dr. R. V. Foster, of Lebanon, and Col. Ruben T. Durrett, of Louisville, for the courtesies and help extended and many favors shown. Without the aid of these and of others who might be mentioned I should have fallen far short of the historical accuracy which I believe to be a
characteristic of the forthcoming work: For my own gratification as well as for that of coming generations, I have gathered the facts presented from every available source, and now give them to the public, trusting that they may both instruct and entertain, – Edward Albright."
To help you see what is in this book, below is the list of illustrations and contents:
ILLUSTRATIONS PAGE Bledsoe's Lick 29 Bledsoe Monument 180 Blount, Gov. William 153 Hall, Gov. William 117 Hall Home, Old 128 Kizer Mound 7 Mansker, Kasper, Former Home 52 Mansker, Kasper and Wife, Graves of 54 Peyton, Bailie 122 Robertson, Gen. James 43 Rock Castle •. 104 Sevier, Gov. John 146 Spencer's Choice 35 Spencer's Tree 33 Trousdale, Gov. William 192 Winchester, Gen. James 150 CONTENTS PAGE Asher's Station, Attack on 79 Boone, Daniel 22 Big Game at French Lick 26 Bledsoe's Lick, Discovered 29 Bledsoe's Station, Attack on 139 Bledsoe, Col. Anthony, Death of 140 Bledsoe, Col. Isaac, Death of 179 Bledsoe's Fort Established 54 Blujfif Fort Established 49 Bluff Fort, Attack on 95 Brown Party, Massacre of 142 Buchanan's Station, Attack on 173 Blackmore, Maj. George D 197 Charleville, Charles ; 18 Cumberland River Named 19 Cumberland Settlement Begun 42 Clark, Gen. George Rogers 44 Clover Bottom Defeat 81 Craighead, Rev. Thomas B 117 Cold Water Expedition 131 Chota, The City of Refuge 158 Caney Fork, Battle of 170 Castleman's Raid 184 Congress Petitioned 186 Compact of Government 68 DeSoto, Ferdinand 12 DeMonbreun, Timothy 20 Donelson's Voyage 56 Donelson, Col. John, Death of 123 Defeated Creek Attack 120 Davidson County Established m Douglass, Col. Edward 125 Evans' Battalion 136 First Indian Settlers 9 First White Man Killed 26 2o6 CONTENTS PAGE First Indian Killed 31 First Corn Crop Raised ^2 First Wedding in Colony 88 First Census Taken 136 Fort Stanwix, Treaty of 40 Forts Located 50 Freeland's Station, Attack on 91 Greenfield Station, Attack on 182 Hunters and Traders 17 Hunting Ground. The 38 Henderson, Col. Richard 40 Hall, Maj. William 116 Hall Family, Massacre of 129 Indian Tribes, Locations 37 Indian Warfare, Beginning of 72 Jackson, Andrew 147 Kilgore's Station Broken Up 102 Licks, Their Formation 17 Lindsay, Isaac, and Party , 24 Long Hunters, The • : • • 25 Legislature Organized 201 Mound Builders 5 Mississippi River, Discovery of 14 Mansker. Kasper 51 Mansker's Party 28 Mansker's Lick Discovered 30 IMansker's Station, Attack on 79 Mero District i53 McGillivray, Alexander 156 Natchez, a Spanish Outpost 27 Nashborough 49 Nickajack Expedition 190 Ponce De Leon 12 Pioiningo. The Mountain Leader 93 Peyton. John 121 Robertson, Gen. James 46 Ren f roe Stationers. Massacre of 77 Rogan, Hugh 86 Spanish Adventures 12 Shawnees, The 9 Scraggins, Henry, and Party 23 Stone's River Named 24 Station Camp Established 28 Spencer, Thomas Sharp, Adventures of 31 Spencer, Thomas Sharp, Death of ;^7 Sycamore Shoals, Treaty of 41 Settlers, Arrival of, at French Lick 4S Smith, Gen. Daniel 103 Sumner County Established 124 Sumner County Forts Established 159 3evier, Col. John 145 Sevier, Col. Valentine 164 Sevier's Station, Attack on 198 Transylvania Company, The 41 Tennessee County Established 142 Tennessee Admitted to the Union 202 Territorial Assembly Meets 185 Walker, Dr. Thomas and Party 19 Wallen's Company 22 White's Creek, Battle of 113 Winchester, Gen. James 151 Zigier's Station, Attack on 167 BUY THIS BOOK


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LIVERPOOL captain Steven Gerrard declared his side "genuine contenders" for the Premier League title after scoring two penalties in a 3-0 victory at Manchester United.
Gerrard broke the deadlock at Old Trafford with a 34th-minute spot-kick after Rafael da Silva was penalised for handball and made it 2-0 a minute into the second half following a foul on Joe Allen by Phil Jones.
He could have had a hat-trick of penalties, putting a third attempt against the post after Nemanja Vidic had been shown a second yellow card for tripping Daniel Sturridge, before Luis Suarez added a late third.
Victory took Liverpool to within four points of leaders Chelsea with a game in hand and although manager Brendan Rodgers has sought to play down his side's title chances, Gerrard has his eyes firmly on the prize.
"We believe that we can win the league," he told Sky Sports. "But the easiest thing in football is to talk the talk. We have to treat (forthcoming opponents) Cardiff and Sunderland the same as Manchester United.
"I maybe got a bit cocky with the last penalty, but scored the two that mattered most." While United will turn their attentions to Wednesday's Champions League last 16 second leg against Olympiakos, when they must seek to overturn a 2-0 deficit, Liverpool have a week to prepare for next weekend's trip to Cardiff City.
Liverpool will face title rivals Chelsea and Manchester City over the closing weeks of the campaign and Gerrard warned his team-mates not to get caught up in the euphoria of a first win at Old Trafford since March 2009.
"I have come here many times before and been played off the park," he said. "They are a fantastic team and this is one of the most difficult places to come in the Premier League.
"To come here and dominate from start to finish -- we're still going away slightly disappointed that we didn't score more goals.
"We will enjoy this tonight, but we'll need to move on quickly. We've showed today that we are genuine contenders and we are going to fight to the end for this." United striker Wayne Rooney, Gerrard's England colleague, described the game as one of the most painful experiences of his entire career.
"It's one of the worst days I've ever had in football," he told United's in-house television station, MUTV.
"It's hard to take. You have to give Liverpool credit -- they played well -- but it's difficult to take. Nobody wants to lose, especially in this way, in your own stadium. It's not nice."
Originally published as Stevie G proclaims: we can win it


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Northern Sichuan Medical College
Northern Sichuan Medical College
Liu Q.-S.,Northern Sichuan Medical College |
Liu Q.-S.,The Affiliated Hospital of Northern Sichuan Medical College |
Yuan G.-H.,The Affiliated Hospital of Northern Sichuan Medical College |
Tang Z.,Northern Sichuan Medical College |
And 10 more authors.
Journal of Xi'an Jiaotong University (Medical Sciences) | Year: 2012
Objective: To detect reticulated platelets (RPs) in patients with system lupus erythematosus (SLE) so as to explore the diagnostic and prognostic values of RPs for SLE. Methods: By using cytoanalyzer, platelets were analyzed in 80 SLE patients and 41 healthy subjects. According to the presence of thrombocytopenia, the SLE patients were divided into SLE plus thrombocytopenia group and non-thrombocytopenia group. Platelet-rich plasma was collected from all subjects through the intravenous blood. RPs were analyzed with flow cytometry. In addition, RPs were assayed in 11 SLE patients before and after medication. We counted the total number of megakaryocytes and classified them and studied the platelets in bone marrow of 21 SLE patients. Results: The initial RPs result was (6.73±6.02)% in SLE patients and (2.31±0.85)% in healthy subjects, with a significant difference (P<0.001). Among the 80 SLE patients, the RPs result was (10.99±7.54)% in the 15 patients, with thrombocytopenia, but (5.04±3.40)% in the 65 non-thrombocytopenia patients with a significant difference (P=0.001). The RPs result in 11 SLE patients significantly decreased from (8.59±7.01)% before treatment to (4.79±3.13)% after treatment (P=0.039). Bone marrow smear test showed that the number of platelets in the SLE patients with thrombocytopenia was significantly reduced compared with those non-thrombocytopenia ones. Thrombocytogenous megakaryocytes were significantly fewer in the patients with thrombocytopenia than in those without (P=0.007) although the two groups did not significantly differ in the number of immature megakaryocytes (P>0.05). Conclusion: RP has auxiliary diagnostic and prognostic values for SLE, especially in patients with thrombocytopenia. Thrombocytopenia in SLE patients may be related to the abnormal maturation of megakaryocytes in bone marrow.
Zhu X.-C.,University of Sichuan |
Zhu X.-C.,Affiliated Hospital of Northern Sichuan Medical College |
Liu Q.-S.,Affiliated Hospital of Northern Sichuan Medical College |
Yang H.-M.,Northern Sichuan Medical College |
Fang D.-Z.,University of Sichuan
Fudan University Journal of Medical Sciences | Year: 2014
Objective: To investigate the expression of end-binding protein 1 (EB1) in cervical tissues and its effect to the expressions of autophagic biomarkers, LC3 and p62/SQSTM1.Methods: The expression of EB1 protein in cervical carcinoma, cervical polyps and chronic cervicitis tissues was detected by mmunohistochemical method. The expression of EB1 in cervical cancer Siha cells was knocked down by siRNA, and then the expressions of autophagic biomarkers, LC3 and p62/SQSTM1 were detected by real-time fluorescent quantitative PCR and Western blot.Results: The EB1 mainly located on the cytoplasm which embraces peripheral of nucleus. The positive expression rate of EB1 in cervical cancer and cervical polyps tissues was significantly lower than those in cervical tissues of chronic inflammation (P<0.05), but the vast majority of interstitial cells were negatively expressed of EB1 in the EB1 positive expression cervical cancer tissues. The positive expression rate of EB1 in middle and low differentiation cervical squamous cell carcinoma tissues was significantly lower than that of high differentiation squamous cell carcinoma tissues (P<0.05). When the expression of EB1 was knocked down in cervical cancer Siha cells by siRNA, the expression of autophagic biomarkers, p62/SQSTM1 and LC3, were significantly increased at both mRNA level and protein level (P<0.05).Conclusions: EB1 in cervical cancer tissues whose autophagy is suppressed is lower expressed than in cervical chronic inflammation tissues whose autophagy is activated. Both p62/SQSTM1 and LC3|, the autophagic biomarkers, are dramatically increased in cervical cancer Siha cells when the EB1 expression was suppressed, which indicates EB1 plays a role in autophagy of cervical carcinoma.
Liu Y.-Q.,Chongqing Medical University |
Luo X.-Y.,Affiliated Hospital of Northern Sichuan Medical College |
Jiang H.,Affiliated Hospital of Northern Sichuan Medical College |
Xia Y.-H.,Northern Sichuan Medical College |
And 2 more authors.
Acta Anatomica Sinica | Year: 2014
Objective: To explore the expressions and implications of end-binding protein 1 (EB1) in autophagic cervical cancer Siha cells. Method Real-time quantitative PCR and Western blotting were introduced to detect the mRNA and protein expressions of EB1, LC3 and p62 in Siha cells treated with Hank's balanced salt solution (HBSS) or colchicine in vitro. Specific green fluoresent protein (GFP)-LC3 was then be detected to confirm the autophagosome formation by fluorescence microscopy with FlowCellect™ GFP-LC3 reporter autophagy assay kit. Result The mRNA and protein levels of LC3 and EB1 in cervical cancer Siha cells were increased significantly when prolong the duration of HBSS treatment (P < 0.05). EB1 mRNA was positively correlated with LC3 mRNA expression (P < 0.05). The expressions of p62 mRNA and protein reduced dramatically after HBSS treated (P < 0.05), and was negatively related with the EB1 mRNA (P < 0.05). The number of cells with GFP-LC3 and intensity of GFP-LC3 per cells were increased when starvation for 12 hours. However, the mRNA and protein levels of LC3, p62 and EB1 were not significantly changed when the cells treated with colchicine (P > 0.05), and we cannot detected the fluoresce signaling of GFP-LC3 in cells at this moment. Conclusion: The expression of EB1 in starved cells is dramatically increased, and accompanied with the increased expression of LC3 and autophagosome, decreased expression of p62. However, when microtubules with which EB1 interaction were destructed by colchicine, the above phenomenon disappears. All these results fully indicate the probably roles of EB1 in autophagy.
Liu Q.-S.,Institute of Rheumatology and Immunology |
Liu Q.-S.,Northern Sichuan Medical College |
Fan Q.-M.,Northern Sichuan Medical College |
Jiang H.,Institute of Rheumatology and Immunology |
And 5 more authors.
Journal of Xi'an Jiaotong University (Medical Sciences) | Year: 2010
Objective: To explore the effect of salvia miltiorrhiza on the apoptosis of fibroblast-like synoviosytes (FLSs) from patients with rheumatoid arthritis (RA). Methods: FLSs were harvested from RA patients by primary culture joint synovial fluid and through 3-5 passages. After treated with salvia miltiorrhiza for 24 h, cells were divided into high-dose (salvia miltiorrhiza's final concentration of 50 mg/mL), low-dose (salvia miltiorrhiza's final concentration of 0.39 mg/mL) and solvent group. The apoptosis of RA FLSs was detected by AnnexinV/FITC and PI with flow cytometry (FCM). Results: Compared with that in control group, cell apoptosis rate in high-dose and low-dose groups treated with salvia miltiorrhiza was significantly increased (P <. 0.05), and it was significantly greater in high-dose group than in low-dose group (P<0.05). Conclusion: Salvia miltiorrhiza can effectively induce the apoptosis of fibroblast-like synoviosytes from rheumatoid arthritis patients.