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HAWKINS COUNTY, TN (WJHL) – A Hawkins County commissioner wants to display the motto "In God We Trust" in all public buildings.
Carolyn McClellan, who lives in Hawkins County, likes the idea.
"I think it's awesome," McClellan said.
Commissioner B.D. Cradic is introducing the resolution that would require all public buildings, offices, schools, including classrooms, and anywhere else students may gather, to have the words displayed.
News Channel 11 was unable to reach Cradic Monday, but fellow Commissioner Robert Palmer spoke about some of his concerns.
"I think it's a good resolution. But there's still several if, ands, and buts that are in it that need to be worked out," Palmer said.
One of his concerns is funding. The county is currently facing a $2 million deficit for the upcoming fiscal year.
"I have no idea how many classrooms there are in Hawkins County. How many public offices, public places. The way the resolution is stated, I have no idea how many this will be but it will be a lot," Palmer explained.
Palmer questioned whether the funding could come from public donations.
But the resolution does mention one solution to help display the motto.
"Classrooms could hold contests and maybe have like a drawing or something of a picture with these words included. Pick one out and that one would be displayed in their classrooms," Palmer said.
He thinks the resolution will probably pass, but not without some controversy.
"If one child in a classroom opposed this being posted in their class, will we have to remove it?"
The full commission will hear the resolution next Monday, March 27 at 7 p.m.
News Channel 11 reached out to Hawkins County Director of Schools, Steve Starnes. He sent the following statement:


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Gullfoss & Geysir
Iceland´s "must-see" nature sights
On this trip we will pick you up from your hotel and drive the scenic route to the beautiful National Park Thingvellir, the active geothermal area of Geysir, and to Gullfoss, the most photographed waterfall in Iceland. All of these sights are a magnificent display of the power and beauty of nature and shouldn't be missed by any visitor in Iceland.
At Thingvellir lake we will do one dive in Silfra. On this dive we will see the whole of Silfra: Silfra Hall, Silfra Cathedral and Silfra Lagoon.
After a day full of impressions we will drive back to Reykjavik to close the Golden Circle and you will surely have no problem falling asleep.
If you want to share the experience with your friends or family who are not scuba divers, you can combine this tour with non-divers and snorkelers. Ask us!
In order to join this tour you must have dry suit certification OR 10 logged dry suit dives within the last two years of tour date and be able to provide written proof from a diving instructor of these dry suit dives.
All year around.
See our guaranteed departures in the booking calendar (click on BOOK NOW below).
We might do other departures on request.
This tour is also available as the Snorkeling Silfra & the Golden Circle Tour.
Participants must:
Please note:
Participants are not allowed on tour without signing the Diving Silfra Medical Statement and, if necessary, a physician's approval which can me found with the Medical Statement. Please read the Diving Silfra Medical Statement prior to booking to make sure that you are eligible for the tour.
Each participant must sign our liability release form at the start of the tour.
8-10 hours
For your safety and convenience we conduct this tour with a minimum of 2 and a maximum ratio of 3 divers per dive instructor.
Please see our booking calendar below for available departures. The pick up time is the time listed in the calendar.

subset: commoncrawl


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Two of a Kind Working on a Full House has some really Awesome giveaways going on now for a summer event. Let me tell you I have been entering and would sure love to win some of them. Here are a few of my favorites.
1. Laptop giveaway ~ who wouldn't love a new laptop. Betty Crocker Fruit Snacks Win &Give Program and Two of a Kind Working on a Full House Have paired up to give one of her lucky winners a laptop ($210 value) ends 5/16.
2. Little Tikes Sprialin' Seas Waterpark ~ also by Two of a Kind Working on a Full House and I think Collin would love this with the balls. You all know how kids love the water I think this toy would be a winner here. Ends 5/16
3. I've already mentioned this one Step 2 Extreme Coaster...oh yeah I'd love to have this one in my yard for all of the kiddies to play on. Who wouldn't. Can enter this one at Two of a Kind Working on a Full House Ends 5/2.
There are A Lot more Giveaways going on right now at Two of a Kind and other great blogs. Hop around you may just find something you want to win. Be sure to tell Dee I sent you if you stop in.
Don't forget about our own giveaway :
Aerobie Sprint Ring Ends 5/4


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GraphicRiver Abstract Party Dj Flyer Template 9585315
Photoshop \ Print Template \ Flyers \ Events \ Clubs & Parties
Electro \ Template \ Techno \ Included \ Stylish \ Events \ Dubstep \ Dafont
Print Template - Abstract Party Dj Flyer Template 9585315 by DogmaDesign @ GraphicRiver
Photoshop \ Print Template \ Flyers \ Events \ Clubs & Parties
This stylish professional flyer template is perfect as flyer for music events and parties.
The modern and minimal style of this product is suitable for every kind of music style.
- House Music
- Dubstep Music
- Hardcore Music
- Techno Music
- Tech House Music
- Electro House Music
- Electro Music
- Any other kind of EDM Music
- Pop Music
- Rock Music
- And many more…
- 2 PSD files
- 2 colors preset
- Fully editable (easily customize your menu template following our step-to-step manual)
- 300 dpi
- A4 + bleeds
- Layered
- Easy color change
- Texture included
- The fonts are not included, but you can download them free here: http://www.dafont.com/it/arual.font | http://www.dafont.com/it/code.font
Feel free to rate if you like it!
Layered: No; Graphics Files Included: Photoshop PSD, Vector EPS, TIFF Image; Minimum Adobe CS Version: CS5; Print Dimensions: 210x297.
Elegant Party and Dj Facebook Cover Template; Pois Vintage Wedding Invitation Pack Template; Vintage Wedding Invitation Pack Template; Musician Facebook Cover Template; Vintage Wedding Square Photo Album Template; Wedding Frame Facebook Timeline Cover Template; Wedding Facebook Timeline Cover Template.
Keywords: abstract, club, dark, deep, design, disco, dj, dubstep, edm, electro, electronic, event, events, festival, flyer, flyer template, hipster, house, minimal, modern, music, parties, party, party flyer, poster, stylish, tech house, techno, triangle, underground.


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Quick Details
- Type: Event & Party Supplies, Bowknot rhinestone cake topper
- Event & Party Item Type: Party Decoration
- Occasion: Wedding
- Place of Origin: Guangdong, China (Mainland)
- Brand Name: Creativebead
- Model Number: CBCT51
- Use: Wedding, birthday, party decoration
- Style: wholesale bowknot rhinestone cake topper wedding decoration
- Color: Clear
- Shipping Way: DHL,UPS,FEDEX ,EMS,TNT
- Supplier Type: Made To Order -OEM
- Price: Competitive
- Size: Any size
- Delivery time: Fast
- Paypal: Accepted
Packaging & Delivery
|Packaging Details
|Opp bag and outer carton
|Delivery Time
|6-8 days
Wholesale Elegant Bowknot Rhinestone Cake Topper for Wedding Decoration
|Item Name
|Wholesale Elegant Bowknot Rhinestone Cake Topper for Wedding Decoration
|Alloy base+rhinestones
|Silver , can be gold
|Rhinestone color
|Cake topper use
|Wedding, birthday, Christmas, party decoration
|OPP bag
|7 days
|1.Mini order is ok . for the first cooperation , 10 pcs is ok
|2. We can supply the free sample to you for checking the quality before you place the order from us
|3.Customization is available .
Rhinestone cake topper
1. Payment term: paypal, western union, T/T, money garm and so on.
2. Shipping way: DHL, Fedex, UPS, EMS or any other way as your requirement .
Established in 2007, Creativebead Garment Accessories Co.,Ltd. is a professional manufacturer and exporter in Guangzhou, China, which specializes in all kinds of garment/wedding/party accessories and decorations. Such as, rhinestone button/buckle/brooch/pendant/cake topper/chain/bikini connector/shoe flower/mesh/sticker/bra belt, acrylic rhinestone/acrylic rhinestone button, hot fix rhinestone/acrylic hot fix rhinestone, various feathers,wedding wine botter stopper/opener, napkin ring, pearl bead, hot fix tape, resin flower, heat transfer film and so on.
Based on efficient productivity and the analysis of international tendency, our company has become a supplier, who not only gives full play to our own advantages in quality, creativity and innovation, but also tries the best to provide superior service .
With international well-known cooperative companies, we have won high reputation among our clients. Focus on customer satisfaction,we provide customers with perfect products and share happiness of creativity with them. Welcome to contact us for more information and we look forward to cooperating with you. Thanks.
1. Are you factory manufacturer?
A: Yes, we are professional manufacturer, we have our own factory in Guanzhou,China.
2. Do you have stock? When can i get it if i pay.
A: For items if in stock, we can send out goods to you within 48 hours. For items not in stock, we need about 6-12 days to make it depend on your order quantity.
3. What is your MOQ? Can I mix different styles to a start order?
A:Please tell us what products you need first. Such rhinestone cake topper, MOQ is 10 pieces for one styles. But we can provide any stock as samples for you check the quality first.
4.Why your price on website not the same as real price?
A:The price on the website is only a rang cost for whole series.
The size, color, quantity and exchange rate ect. these factors affect the price.
The real price is floating, so prices are subject to our final confirmation.
5.How about your after servise?
A: Once sent out the goods, we will provide the waybill tracking number for you.
If you are not satisfied with the goods received, please contact us within 7 days upon receiving! Let us find a satisfactory solution!
Any Questions , Welcome to Contact US !


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MD Anderson Events
Internal Medicine and Cancer Survivorship Grand Rounds
Management of Acute Myocardial Infarction
H. Vernon Anderson, M.D., professor of Medicine, UT Health Science Center Houston
Date: 11/16/12, 8am to 9am
Time: 11/16/12, 8am to 9am
Location: Pickens Academic Tower, Floor 3, Room 1 (FCT3.4167)
Format: Grand Rounds
CME: 1 AMA PRA Category 1 Credit
Contact: Judy Overton - (713) 792-8031 - firstname.lastname@example.com
Related Events
- PRIM Grand Rounds
- Anesthesiology and Perioperative Medicine Grand Rounds
- Emil J Freireich Leukemia Hematology Grand Rounds
- DoCM Grand Rounds
- PRIM Grand Rounds
- Emil J. Freireich Lymphoma/Myeloma Grand Rounds
- Heart Failure with Preserved Ejection Fraction: A Phenotypic Approach
- CPC Grand Rounds - Preclinical and Clinical Perspectives in Pancreatic Cancer Development and Progression
- PRIM Grand Rounds
Contact Us
Questions? Need help?
Want to request an appointment?
Call askMDAnderson


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New LaCie Hard Disks By Designer Neil Poulton
This isn't the first time LaCie has allowed other designers to help them market their products, but admittedly, their products are always refreshing to look at. Their latest product is definitely no exception, designed by Neil Poulton and boasts three interfaces: USB 2.0, FireWire 400, and eSATA.
As you may have guessed, functionality-wise, you won't be seeing anything really new. It's still standard plug-and-play, load and store. However, the added eSATA interface is definitely an added plus since it's much faster than its two brotherly ports. Pricing are as follows: 500GB for $169.99, 750GB for $229.99, and 1TB for $339.99.
[more info at lacie.com]


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10418 Rankin Road, Glenford, Ohio
$325,0004 Beds3+ BathsActive
$325,0004 Beds3+ BathsActive
10418 Rankin Road, Glenford, Ohio 43739 - Beautiful Cape Cod home with 4 bedrooms, 3.5 baths, on 1.703 acres, 3 car attached garage, inground heated pool, custom interior, spacious floorplan, full walkout basement. 40 minutes from Columbus.
Listing Courtesy of Kevin S McCollister (740) 455-4300 - McCollister & Assoc. Inc. (740) 455-4300
"The Parrett Group was amazing to deal with. They always went above the call of duty and were helpful before we listed, durring the sales process and after closing to ensure that we were completely satisfied. Anyone buying or selling a home in The Parrett Group's territory that uses another agent is wasting their time and money."


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NRA's Guns and Gold – Reveals the fascinating and entertaining true stories of treasured firearms in an Antiques Road Show style format. Experience the excitement – or disappointment – as collectors learn the real value of their possessions – including a $100,000 Winchester. This new series features everyday people who discover their old firearm is worth much more than they imagined – and where others will learn it has only sentimental value. Each episode will send viewers scrambling to their safes, closets and basements to find their own hidden treasures. Some of the guns featured in the show have been passed down for generations and include a story as interesting as the gun itself. Viewers learn what makes an old gun valuable and what they should and should not do to preserve its value. A special gold segment will feature an expert from Universal Coin & Bullion who will examine the special features of those old coins you may have laying around and what contributes to their worth beyond their mere melt value.
Channel: Sportsman Channel
TX: January 2012
Source: Sportsman Channel


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Back to top
Johnstone's Knob Area Mostly Trad climbing11 routes in area
First time here?theCrag.com is a free guide for rock climbing areas all over the world, collaboratively edited by keen rock climbers, boulderers and other nice folks.You can log all your routes, connect and chat with other climbers and much more...» go exploring, » learn more or » ask us a question
Stats and downloads
Get directions to here using Google Maps.
An isolated 40 ft. tower to the north of the 'Northern Buttress'. A faint trail heads right from near the Chasm and runs around the 'Lost World' and uphill to the "Knob". There are 2 or 3 ways to the top. Descent by abseil.
First climbed Sept. '61.© (eijkel)
Some content has been provided under license from: © Australian Climbing Association Queensland (Creative Commons, Attribution, Share-Alike 2.5 AU)
Check out what is happening in Johnstone's Knob Area.


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Corbin's Bend is perfect for Marilyn and Lizzy Mayfield. They're surrounded by friends and peace. Except for when Calbert Jolly comes around. From the moment they met, Lizzy and Calbert had fought with one another. Usually able to get along with anyone, no matter how contrary, Calbert is a thorn in Lizzy's side.
When she's asked to manage a committee Calbert's in charge of, sparks fly. It's up to her wife Marilyn and his wife Jenna to bring the two together. One dinner. Two intense adversaries. By the end of the night, they will either be on working terms, or have killed one another.
When all's said and done, sometimes wrongs can turn out all right on their own, and sometimes they have to be righted.
Corbin's Bend Vignettes are shorter stories, chronicling the lives of secondary characters we don't see as much of.
Wrongs Made Right was a nice little journey back to Corbin's Bend for me. I really do miss that place and all of its residents. I loved that we got to see how Lizzy and Marilyn met and how they came to be residents of Corbin's Bend. While I enjoyed the novelette, I must admit that I was a bit taken aback by Calbert's behavior toward Lizzy. As he's an HoH, I was surprised by what seemed to be rather childish behavior on his part. Initially, I thought that perhaps Lizzy was just overreacting, but his antagonistic comments during their meeting and later during the dinner really had me going… just like they did Lizzy. And while I eventually understood why he was doing what he was doing, I was a bit perturbed on Lizzy's behalf about it because Marilyn had disciplined her in the past for her behavior toward him. But, we all have to deal with people who push our buttons on a daily basis, so even though Calbert annoyed me, I enjoyed watching them snipe at one another and laughed upon learning that Lizzy can certainly serve up one heck of an insult.
Now, I did have an issue with Lizzy and Marilyn's intimate moment. It's a completely person issue and has nothing to do with the writing, the fact that it's two women, or the scene itself. And I suspect that anyone who reads this review and my so-called complaint will most likely laugh at my predicament, but here it is. Just as the ladies are getting hot and heavy, a reference is made to Marilyn's age while Lizzy is playing with her partner's hair – Long and thick, lustrous even at the age of sixty-one, just like the woman it belonged too. Unfortunately, my mother is sixty-one and that age reference made me think of my mother, which is the last person I want to be thinking about when reading a sex scene. Laugh at me all you will, but that was equivalent to having a glass of ice water thrown on me so I have no comments on the heat level between Lizzy and Marilyn. Other than that, I enjoyed the heck out of Wrongs Made Right and getting to revisit my favorite spanko community.


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Friday, November 24, 2017
Contact Us - Site Map
The Sault Ste. Marie Innovation Centre offers Geographic Information Systems (GIS) consulting services based on the impressive expertise of its GIS team. In 2000, SSMIC formed the Community Geomatics Centre (CGC) to assist the City of Sault Ste. Marie and the Public Utilities Commission (PUC) in the efficient retrival, reproduction and analysis of spatially related municipal and utilities infrastructure.
The CGC developed an award-winning Integrated Geomatics Model, touted as the most comprehensive in Canada, to support multiple applications.
At the core of the CGC solution is a dynamic team of highly skilled IT professionals, cutting edge municipal, utilities and health data models, tools and a highly secure data warehouse. The CGC Partners' data sharing is secure and efficient within the limits of each organization's privacy policies. Generally, the data sharing is by postal code, neighbourhood or census tract area.
For more information the Community Geomatics Centre, please click here.


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Hotel Innside Palma Bosque
- Terms and facilities
- Useful information
- Location
- Opinions
When you stay at Innside Palma Bosque in Palma de Mallorca, you'll be connected to the airport and minutes from Auditorium de Palma de Mallorca and Gomila Square. This hotel is within close proximity of Pueblo Espanol and Bellver Castle.
Make yourself at home in one of the air-conditioned rooms featuring air conditioning. Wireless internet access keeps you connected, and satellite programming is available for your entertainment. Private bathrooms feature toiletries. Conveniences include phones, as well as safes and desks.
Take advantage of recreational opportunities offered, including a health club, an outdoor pool, and an indoor pool. This hotel also features concierge services.
Enjoy a meal at a restaurant or in a coffee shop/café. Or stay in and take advantage of the hotel's room service.
Featured amenities include a business center, express check-in, and newspapers in the lobby. Planning an event in Palma de Mallorca? This hotel has meeting rooms.
Choose your room
Share it
Score based on 19 reviews
Average price per night for this hotel for the following weeks
|24/11/17 - 26/11/17
|27/11/17 - 3/12/17
|4/12/17 - 10/12/17
|11/12/17 - 17/12/17
Services and terms: Hotel Innside Palma Bosque
Standard Room Services
- Air Conditioning
- Safe
- Minibar
- Satellite TV
- Hairdryer
- Telephone
- Television
Accommodation facilities
- Lift
- Bar/Café
- Business Centre
- Money Exchange
- Meetings Room
- Internet Centre
- Laundry
- Medical Service
- Non-smoker Rooms
- Parking
- Restaurant
- 24 hr Room Service
Leisure facilities
- Bicycle Hire
- Gym
- Swimming Pool
- Sauna
Useful information: Hotel Innside Palma Bosque
Other names for Hotel Innside Palma Bosque:
Tryp Palma Bosque
Bosque Tryp
Tryp Bosque
Tryp Bosque Palma Hotel
Location: Hotel Innside Palma Bosque
This friendly hotel lies in the El Terreno area of Palma de Mallorca, an approximately 5 minute bus ride from the Plaza Gomila, the nightclubbing district of the city. There is a bus stop with regular links to other areas, directly in front of the hotel. Bellver Castle is 300 metres away, the airport is 10 kilometres away and Illetas Beach is 4 kilometres from the hotel.
Reviews: Hotel Innside Palma Bosque
6.8My opinion about this hotel Tryp Palma BosqueSimon - 5 Jul, 2014
The staff were very friendly and helpful, always greeted you on passing and gave you advice on best places to eat and visit plus travel info too.
The hotel is pretty basic but you get what you pay for in a location that is not too far from the city centre (apprx 25 mins walk). There are scuffs and broken bits and pieces around the hotel.
I didn\'t really like the decor or the room, it looked dated, tired and in need of refurb. The bed was not comfy and the sheets felt like cardboard. Breakfast was nice and I like the fact that you had until 10,30am meaning we can get up a bit later.


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Personnel Department
Welcome to the Lake Havasu Unified School District Personnel Department home page. Lake Havasu City, home to the world famous London Bridge, is a growing desert community located in the foothills of the Mohave Mountains in western Arizona on the beautiful Colorado River. We are a community inspired by possibility and rich with promise. Our young city responds to a common purpose: To build a future dependent on our single most precious resource, our youth.
Our school district consists of 6 elementary schools (pre K-6), 1 middle school (7-8), and 1 high school (9-12). Total student enrollment is over 5500 students. We have about 650 staff members with 300 certified positions.
Our mission here in the personnel department is threefold.
- To offer an attractive, competitive wage and benefits package.
- To market Lake Havasu Unified as a great place to work, and Lake Havasu City as a great place to live.
- To help provide a strong support system for our employees.
- Mentoring program for new teachers.
- Professional development classes.
- Art, Music, and PE teachers at every school.
- Latest aids to student achievement.
We are currently accepting applications.


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Wale Calls Kendrick Lamar One of Top 5 Rappers of All TimeWale credits Kendrick's lyrical ability as well as his power and weight because K. Dot is loved by mainstream and the streets.
Wale Remixes Ed Sheeran's 'Shape of You'The rapper adds a steamy verse to the beginning of the track.
Wale Drops New Single 'My P.Y.T'The track puts a new spin on Michael Jackson's "P.Y.T."
Watch Wale Become First Rapper to Open The State of The Union AddressWale becomes first rapper to open for The State of The Union Address.
Wale Speaks Up: 'I Want Black Lives to Matter to Black Lives More'"I don't care about trying to rally up people for the wrong reasons."
Miguel Updates 'Coffee' with Wale Verse: ListenIt's the new song off Miguel's 'WILDHEART,' out this year.
Wale and Jerry Seinfeld Call Rick Ross in New Video: WatchWale and Jerry Seinfeld ring up Ricky Rozay in a new promo clip.
Kanye West Could Be Designing Jerseys for the Washington WizardsIn a new interview with ESPN, Wale claims that Kanye West got a solid client for his budding designing career: the Washington NBA basketball team, for which Wale is a creative liaison.
Miguel & Wale Do A Sexy Cover Of Elton John's "Bennie And The Jets" Everything Miguel does is sexy, but his latest venture--a cover of Elton John's iconic song "Bennie and The Jets"--is a shimmering example of how to do a cover right. Miguel takes his classic R&B song, mixes it with some funky, psychedelic production, and brings rapper Wale on to guest.
Lorde's "Royals" Gets Remixed By Wale & Rick Ross
Jay-Z Announces 'Made in America,' Takes Roc Nation To UMG
Wale Announces Third Album 'The Gifted'


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Bell Ringer 1-27-11. Triangle A is dilated to create Triangle B. A B What type of dilation occurred? Calculate the scale factor. Calculate the original area. Calculate the new area. How is the area affected?. 5 cm. 10 cm. 8 cm. 4 cm.
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
Triangle A is dilated to create Triangle B.
5 cm
10 cm
8 cm
4 cm
Triangle A is dilated to create Triangle B.
5 cm
10 cm
8 cm
4 cm
Triangle A is dilated to create Triangle B.
4. Calculate the new area.
5 cm
10 cm
8 cm
4 cm
Triangle A is dilated to create Triangle B.
5. How is the area affected?
Say NO to Oreos!
5 cm
10 cm
The new area is ¼ the size of the original area.
8 cm
4 cm
What is the length of segment BD in the diagram?
What is the length of segment BD in the diagram?
What is the length of the diagonal?
Diagonal or BD
Leg = 6 units
Leg = 8 units
Right Triangle
To find the length of the diagonal, I used the Pythagorean Theorem. I counted the number of units in each leg, and I squared them. I added the squares of the legs together. I took the square root of the area to find the length of the segment.
The diagonal is 10 units long.
1. Get out a dry erase marker.
2. You have 1 minute to complete as many problems as you can.
We will grade in 1 minute.
4. Graph your results. Keep the graph in your notebook.
5. We will do this every day.
1. You have 5 minutes to work on the problem of the week and word problem.
2. The problem of the week must follow the Read, Think, Solve, Justify format.
3. When you are finished, turn them in.
4. They are due Friday.
Four friends go to dinner. The total bill is $65.23. Rebecca pays $18.11. Isaac pays 30% of the bill. Jasmine pays 1/3 of the bill. Kendall pays the remainder. Which friend pays the majority of the bill?
A. Rebecca
B. Isaac
C. Jasmine
D. Kendall
You need your notes. Title the notes: Volume of Prisms and Cylinders
I will check your work at the end of class.
The amount of "stuff" a container can hold.
Square units = units2
Cubic Units = units3
Follow these steps in order to calculate volume of prisms and cylinders:
5 in
4 in
7 in
Rectangular prism
7(4) = 28 in2
h = 5 in
140 in3
3 ft
2 ft
Rectangular prism
2(3) = 6 ft2
h = 6 ft
36 ft3
Volume = Area of Rectangle (Height)
3 yd
2 yd
Triangular prism
h = 8 yd
24 yd3
8 ft
5 ft
10 ft
Triangular prism
h = 5 ft
200 ft3
Volume = Area of Triangle (Height)
4 in
7 in
h = 7 in
351.68 in3
3 ft
4 ft
h = 4 ft
113.04 ft3
Volume = Area of Circle (Height)
Volume of Prisms & Cylinders
Do NOT Write on my sheet!
Show Every Step!!!


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Items where Subject is "Agriculture > Agriculture (General) > History"
Group by: Creators | Item Type
Number of items at this level: 2.
Platz, G.J. and Sheppard, J.A. (2007) Sustained genetic control of wheat rust diseases in north-eastern Australia. Australian Journal of Agricultural Research, 58 (9). pp. 854-857.
Silcock, R.G. and Scattini, W.J. (2007) The original native pasture ecosystems of the eastern and western Darling Downs - Can they be restored? Tropical Grasslands, 41 (3). pp. 154-163.


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Pro2col are a Globalscape Certified Master Partner and have been working with Globalscape to provide, deploy and support their solutions to businesses throughout the UK since 2011.
Globalscape, Inc. is a leading provider of secure data exchange solutions for thousands of customers worldwide from global enterprises to small businesses. Recognised as a leader in Gartner Group's Magic Quadrant for Managed File Transfer, Globalscape's products allow organisations to intelligently and securely manage sensitive information in transit and at rest, between customers and business partners.
Globalscape solutions ensure compliance with government data security and privacy regulations as well as corporate security policies and mandates. With their recent acquisition of secure mobile access company TappIn, Globalscape now also offer their customers innovative mobile file sharing capabilities.
Founded in 1996, Globalscape has sustained its leadership position by transforming from a consumer products corporation to a leading enterprise solution provider, trusted by the majority of the Fortune 100 and widely deployed by the US Army and other government organisations.
Mail Express
Globalscape Mail Express enables users to securely email large files directly through Microsoft Outlook or an easy to use web interface with one, easy click and no technical knowledge needed. Find out more…
Wide Area File Services (WAFS)™
WAFS™ is a powerful file replication software that enables businesses and employees to instantly access and share files across multiple offices worldwide. Find out more…
Other Globalscape File Transfer Solutions include;
Globalscape EFT Server
Globalscape Enhanced File Transfer (EFT) is a powerful managed file transfer platform that enables your organisation to securely manage file transfers among worldwide offices, clients, and partners. EFT offers unmatched simplicity and top-notch security trusted by companies large and small, including the U.S. Army and the Fortune 100…..Read More


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This article or page contains information on something either EXPERIMENTAL or NOT YET IMPLEMENTED. Various details are subject to drastically change over the course of development. See Planned Content for more information.
The Henchman is an in-development class for a planned gamemode Overpowered. The character is still in the planning phase.
In Overpowered, a player is randomly selected before each round to play as the Henchman on the BLU team. All other players participate on the RED team.
The Henchman can only utilize melee weapons under normal circumstances, and is susceptible to headshots, Critical Hits, and Afterburn.
The Henchman spawns with an extremely large health pool that scales with the amount of players in the server. Then, as the Henchman receives damage, their damage output is increased up to a max of +210%.
Additionally, the boss can initiate a charging attack that will quickly move them forward, allowing them to attack faster classes.
These abilities allow the player to stand a chance against servers filled with large amounts of players.
|Scout • Soldier • Pyro • Demoman • Heavy • Engineer • Medic • Sniper • Spy
|Civilian • Mercenary • Henchman


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CLICK HERE to read Alma 45.
When the Lord delivered the people again, they did rejoice and give thanks, even fasting and praying and worshiping in joy (verse 1). In these ways they remembered their God, and thanked Him for what He did for them. This kept peace in the land, and the people prospered. But the moment they forget God, or become proud and think their success is their own, and stop acknowledging the Lord's hand in their lives, they remove themselves from His blessings. The rest of the book of Alma is about the consequences that happen when we do this.
Alma, Jr., knows this, and has worked to teach his sons at a personal level the same lessons the people are learning as a whole. There are always these parallel layers, both what is happening to us as a people and what is happening to us individually. Alma asks his son Helaman if he understands this, if he believes the records which have been kept and passed down by the prophets (verse 2). Helaman affirms that he does believe (verse 3), so Alma then asks if Helaman believes in Jesus Christ, and that He will soon come (verse 4). Helaman says that he does (verse 5), and Alma asks for the evidence: whether or not Helaman will keep the commandments (verse 6). Helaman says that he will keep the commandments "with all my heart" (verse 7).
This satisfies the personal interview, and Alma blesses his son, telling him that he will be blessed spiritually and temporally for this faith and obedience (verse 8).
Alma then prophesies also, commanding Helaman not to share the prophecy publicly until it is fulfilled, but to go ahead now and add the prophecy to the records being kept and passed down (verse 9). Alma's prophecy is that within four hundred years of Jesus Christ manifesting himself to the Nephites, they will "dwindle in unbelief" (verse 10). He says this will causes "wars and pestilences, yea, famines and bloodshed, even until the people of Nephi shall become extinct" (verse 11). These will be the consequences, he says, of the people no longer believing, choosing works of darkness – even literally in the form of lascivious sins (verse 12). The people will get so sucked into this darkness, that they and their descendants will no more be people of the covenant (verse 13).
But then he adds more! The few who DO remain in the covenant, who are believers, will be counted among the Lamanites (verse 14). This is huge! At the time when Alma is talking to his son Helaman, the Lamanites are the hater-non-believers, and the Nephites are the believers. Alma is saying this is going to switch, because the Lamanites will become believers and accept the gospel, while the Nephites will become the hater-non-believers. Whoa!
So this was his prophecy shared with Helaman in a blessing, and then Alma also blessed his other sons (verse 15). He also, in the role of prophet, "blessed the earth for the righteous' sake" (verse 15), which means he also cursed the land when the people do wickedly (verse 16). Alma then blessed the church, meaning those truly converted and remaining faithful for always (verse 16).
Then Alma left, and "was never heard of more; as to his death or burial we know not of" (verse 18).
Behold, this we know, that he was a righteous man; and the saying went abroad in the church that he was taken up by the Spirit, or buried by the hand of the Lord, even as Moses. But behold, the scriptures saith the Lord took Moses unto himself; and we suppose that he has also received Alma in the spirit, unto himself; therefore, for this cause we know nothing concerning his death and burial (verse 19).
And so Alma, Jr.'s son, Helaman, becomes the next prophet and record keeper (verse 20). He finishes Alma's record for the rest of this book, telling the history of the people as they make choices and reap the consequences, just as prophesied by his father.
How does it happen, when these believers have been through so much and know so much?
It happens in a very simple way: they simply forget God, both to thank Him and to choose Him.
Agency is NOT our ability to choose. Agency is our ability to choose whom to follow.
And the Nephites begin to surrender their agency by forgetting to choose to follow God.
This develops dissension and disturbances that distract from their covenants (verse 21), and so Helaman and his brothers and other leaders go throughout the land "to establish the church again", including establishing the priesthood (verse 22).
This is very similar to where we are today, with the church being established, and the priesthood being set up and spread out – with our prophets and apostles warning us because we have the authority but will not turn to God to develop the power. It is a precarious place to be, and dangerous if we do not remember to choose God.
As the priesthood and leaders were set up, instead of developing the power of the priesthood through faithfulness and service, and establishing peace by becoming the people of holiness (establishing Zion), they would not listen to the prophets and apostles and leaders (verse 23). They, like us, had the authority but did not do the work to develop the power. They forgot to choose to follow God:
But they grew proud, being lifted up in their hearts, because of their exceedingly great riches; therefore they grew rich in their own eyes, and would not give heed to their words, to walk uprightly before God (verse 24).
And that was the beginning of their end, just as Alma prophesied.


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Arsenal Away Shirt (L) 2002/03 *HENRY 14*
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Baked flautas stuffed with seasoned, shredded chicken, spinach, and cheese are crispy, but don't have the greasiness of fried versions. To shred poached chicken easily, put it into the bowl of a stand mixer fitted with the paddle attachment and mix on medium for 45 seconds. Store-bought rotisserie chicken can be substituted for the poached chicken to save time. You might also like Buffalo Chicken Taquitos
Calories: 181 Fat: 9 Carbohydrates: 6.3 Fiber: 1.2 Protein: 18.5


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Excessive erythrocytosis results in severely increased blood viscosity, which may have significant detrimental effects on endothelial cells and, ultimately, function of the vascular endothelium. Because blood-brain barrier stability is crucial for normal physiological function, we used our previously characterized erythropoietin-overexpressing transgenic (tg6) mouse line (which has a hematocrit of 0.8–0.9) to investigate the effect of excessive erythrocytosis on vessel number, structure, and integrity in vivo. These mice have abnormally high levels of nitric oxide (NO), a potent proinflammatory molecule, suggesting altered vascular permeability and function. In this study, we observed that brain vessel density of tg6 mice was significantly reduced (16%) and vessel diameter was significantly increased (15%) compared with wild-type mice. Although no significant increases in vascular permeability under normoxic or acute hypoxic conditions (8% O2 for 4 h) were detected, electron-microscopic analysis revealed altered morphological characteristics of the tg6 endothelium. Tg6 brain vascular endothelial cells appeared to be activated, with increased luminal protrusions reminiscent of ongoing inflammatory processes. Consistent with this observation, we detected increased levels of intercellular adhesion molecule-1 and von Willebrand factor, markers of endothelial activation and damage, in brain tissue. We propose that chronic excessive erythrocytosis and sustained high hematocrit cause endothelial damage, which may, ultimately, increase susceptibility to vascular disease.
- erythropoietin
- blood-brain barrier
- vascular permeability
adequate oxygen delivery is crucially important for central nervous system function, because the brain has a low capacity for anaerobic metabolism. Plasma concentrations of the hematopoietic growth factor erythropoietin (Epo) control the O2-carrying capacity of the blood (12). Epo is produced primarily in the adult kidney and fetal liver and was originally believed to play a role restricted to stimulation of proliferation of early erythroid precursors and differentiation of the erythroid lineage. However, a diverse array of cells have been identified that produce and/or express the Epo receptor, such as endothelial cells (2, 29, 34), smooth muscle cells, and cells of the central nervous system (10, 30). In vitro, Epo has been shown to regulate a variety of neural functions, including calcium flux (3, 25), neurotransmitter synthesis (26), and cell survival (9, 40). Furthermore, Epo has neurotrophic effects (14, 19), can induce an angiogenic phenotype in cultured endothelial cells (34), is a potent angiogenic factor in vivo (18), and has recently been shown to modulate the hypoxic ventilatory response (41). Clinically, lack of Epo leads to anemia, fatigue, and cellular hypoxia; thus recombinant human Epo is frequently used therapeutically to increase red blood cell number and O2 delivery. However, during therapeutic use of Epo, vascular system defects have arisen, stimulating interest in possible negative interactions of Epo with the endothelium (5, 32).
In particular, excessive erythrocytosis results in abnormally high blood viscosity and is often associated with severe clinical complications, such as hypertension and thromboembolism (6). The effects of Epo overexpression and resultant high hematocrit on blood vessel function and structure have not been fully investigated. Clearly, the integrity of blood vessel wall structure in all organs is essential to facilitate efficient blood transport/perfusion and the subsequent oxygenation of all tissue beds. Vascular remodeling to suit local tissue needs may therefore be an important adaptation to excessive erythrocytosis. Cerebral capillaries and, specifically, the endothelial cells that are in direct contact with high blood viscosity may be significantly altered by excessive erythrocytosis and undergo changes in permeability and structure. Such alterations/modifications in cerebral vascular function may compromise blood-brain barrier (BBB) integrity.
There has been no good animal model for study of adaptive mechanisms to excessive erythrocytosis. We have generated a mouse model (designated tg6) that constitutively overexpresses human Epo in an O2-independent manner. Generation and characterization of the line has been previously described (37, 45, 46). In these mice a hematocrit of 0.8–0.9 at 8–9 wk of age increases blood viscosity without altering blood pressure, heart rate, or cardiac output; exercise performance is reduced, and life span is significantly reduced. Endothelial nitric oxide synthase levels and circulating nitric oxide (NO) levels were markedly elevated, leading to increased vasodilatation, which protects these mice from cardiac complications (37).
Using this transgenic model, we have investigated the impact of excessive erythrocytosis, as a result of Epo overexpression, on brain vascular structure and function. We demonstrate that excessive erythropoiesis, i.e., high hematocrit, elevated blood viscosity, and high NO levels known to contribute to increased vascular permeability, is detrimental to the brain vasculature, ultimately culminating in microvascular/endothelial injury.
All experiments were performed in accordance with Swiss animal protection laws and Zürich University institutional guidelines. The transgenic mouse line was generated by pronuclear injection of the full-length human Epo cDNA driven by the human platelet-derived growth factor (PDGF) B-chain promoter and has been previously described (37). The resulting mouse line, TgN(PDGFBEPO)321ZbZ (tg6), showed increased plasma and brain levels of Epo (48) and was bred by mating hemizygous males to wild-type C57BL/6 females. Half of the offspring were hemizygous for the transgene, and the other half were wild-type and served as controls. Male and female mice were used at 4–5 mo of age.
Vessel counting and diameter measurements.
Mice were anesthetized with 30% O2 and 4% halothane in N2O and then perfused via the abdominal aorta with reduced (2%) halothane anesthesia according to Forssmann et al. (12a). Briefly, initial blood clearance was performed using an isosmolar solution containing 0.5% procaine hydrochloride and 0.025% heparin followed by fixation with a sodium phosphate-buffered formaldehyde-glutaraldehyde solution (each 1.5%) and then a more concentrated solution of 3% formaldehyde-glutaraldehyde containing 0.05% picric acid. After brain removal, small 1-mm cubes of different brain regions were dissected and postfixed in the second fixative overnight. The cubes were embedded in Epon-araldide resin, cut into 0.5-μm sections, and mounted on glass slides. After they were stained with toluidine blue, the sections were observed microscopically (Axioplan, Zeiss, Oberkochen Germany). Capillary density and luminal area of the microvessels were determined with an image-analyzing system (MCID, Imaging Research, St. Catherine, ON, Canada). In each group, ∼14,000 capillaries from 4 mice were analyzed.
Electron microscopy.
Mice were perfused through the heart with 2.5% glutaraldehyde in 0.1 M cacodylate buffer (pH 7.4, 350 mosM). Tissue blocks were fixed in the same solution for '3 days. The blocks were postfixed in 0.1 M sodium cacodylate (pH 7.4), dehydrated in ethanol, and embedded in Epon 812. Glass knives were used to obtain 1-μm-thick sections, which were stained with toluidine blue and analyzed using a light microscope. From the thick sections, thin (80 to 90 nm) sections were cut, grasped with Formvar-coated copper grips (Fluka Chemie, Buchs, Switzerland), and then double stained with lead citrate and uranyl acetate. Sections were viewed using a Phillips EM400 electron microscope.
Evans blue permeability assay.
A 1% solution of Evans blue dye (2 μg/g body wt iv) was injected into mice via the tail vein. After the injection, the mice were placed in a hypoxic (8% O2) chamber for 4 h after a 1-h acclimatization period from 20% to 8% O2 in 10-min steps per 2% O2 decrease. After normoxic or hypoxic exposure, the mice were anesthetized intraperitoneally with ketamine-xylazine and then perfused intracardially with ice-cold PBS. After 15 min of slow perfusion, the organs were dissected, and the dye retained in the tissue parenchyma was extracted with formamide (5 μl/mg organ wt) for 72 h at room temperature. Absorbance was measured at 620 nm. Additional experiments were also performed with Evans blue dye injections only after hypoxic exposure, with 45 min allowed for circulation before anesthesia and perfusion. Results were consistent using both methods, and no significant differences were observed between male and female mice.
Western blotting and antibodies.
Experiments were carried out on brain lysates of normoxic transgenic and littermate controls or mice exposed to 4 h of hypoxia (8% O2). Tissue was homogenized in lysis buffer by hand using a sterile Dounce homogenizer. Samples were centrifuged at 13,000 rpm at 4°C for 10 min, and the supernatant was extracted and stored at −20°C. Protein (50 μg) was run on a 10% SDS-polyacrylamide gel, transferred to a nitrocellulose membrane, blocked in 5% nonfat milk-PBS, and then incubated with anti-hypoxia-inducible factor (HIF)-1α IgY (7), antioccludin, anti-zonula occludens (anti-ZO-1, 1:1,000 dilution; Zymed, San Francisco, CA), or anti-intercellular adhesion molecule-1 (ICAM-1) or anti-von Willebrand factor (vWF; both 1:200 dilution, Santa Cruz Biotechnology, Santa Cruz, CA) antibodies overnight at 4°C or for 2 h at room temperature. Membranes were washed with PBS containing 0.1% Tween and then incubated for 1 h with a horseradish peroxidase-conjugated secondary antibody. Chemiluminescent detection was carried out, and the membrane was exposed to Kodak autoradiography film. Normalization was performed by reprobing filters with β-actin or Sp1 (1:5,000 dilution; Sigma, St. Louis, MO).
Statistical analysis.
Graphic and statistical analyses were performed using Microsoft Excel and Prism software. Values are means ± SD. Statistical significance (P < 0.05%) was calculated using an unpaired t-test of independent samples with equal variance.
Vessel number and diameter are altered in tg6 mice.
We investigated the impact of excessive erythrocytosis on vessel distribution in tg6 mice by measuring the total number of vessels and their diameters compared with wild-type normoxic littermates. The results of this study are graphically presented in Fig. 1. We observed a significant decrease (16%, P = 0.0425) in the overall number of vessels in the transgenic mouse brain (13,401 and 14,000 in tg6 and controls, respectively) compared with wild-type mice (Fig. 1A). In addition, there was a significant increase (15%, P = 0.0358) in the vessel diameter of tg6 compared with wild-type mice (Fig. 1B).
HIF-1α protein levels are downregulated in hypoxic brain tissue.
Because of difficulties in measuring Po2/Pco2 of the arteries and veins in our mice, we investigated the protein levels of HIF-1α after hypoxic exposure as an indirect measure of cellular hypoxic stress (15). Western blotting of nuclear brain extracts showed that, under hypoxic conditions, induction of HIF-1α is significantly reduced (P = 0.015) in tg6 animals compared with wild-type mice (Fig. 2). Furthermore, induction of a well-characterized HIF-1 target gene, vascular endothelial growth factor (VEGF), is also reduced in tg6 mice subjected to hypoxia (data not shown). This finding supports the notion that O2-carrying capacity in these mice is increased and that this increase may even raise the hypoxic tolerance of tg6 mice compared with wild-type animals.
Permeability of brain vessels remain unaltered in tg6 mice.
Excessive erythrocytosis causes increased blood cell number and viscosity, which might have an impact on normal vessel function and BBB integrity. To investigate the integrity of brain vasculature of tg6 mice, i.e., alterations in vessel permeability, we used a quantitative Evans blue dye assay, which enabled us to directly compare dye extravasation from vessels into the surrounding parenchyma in transgenic and wild-type mice exposed to normoxic or acute hypoxic conditions. Figure 3 shows no increase in brain permeability in tg6 mice compared with wild-type mice (n = 10). The brain remained extremely dye impermeable, with no variation in the tg6 or wild-type mice under normoxic or hypoxic conditions. Therefore, not only is the brain vasculature impermeable and stable, acute hypoxic insult does not appear to accelerate breakdown of tight junctions or disturb the BBB.
Tight junction proteins are expressed in tg6 brain.
Evans blue extravasation studies revealed that, despite changes in vessel number and morphology, permeability of the BBB remained unaffected by excessive erythrocytosis in tg6 mice, suggesting that they have developed adaptational characteristics that promote normal vessel function. The permeability of vessel walls is determined and maintained by expression levels of tight junction proteins such as occludin and ZO-1. Thus we employed Western blot analysis to monitor expression levels of these tight junction proteins and to ascertain whether they are increased in tg6 compared with wild-type mice. Interestingly, there was no significant difference in overall levels of occludin in tg6 and their wild-type littermates under normoxic or hypoxic conditions (Fig. 4). Similar results were obtained in Western blot experiments with ZO-1 (data not shown). Although no significant upregulation of protein levels was observed, the reduced number of vessels in tg6 mice indicates an increase in the number of tight junctions per vessel, which may contribute to maintenance of normal vascular function in our tg6 mice.
Electron microscopy shows morphological alterations in brain endothelium.
To closely investigate any morphological changes in the microvasculature of tg6 mice, we employed electron-microscopic analysis of brain sections and compared them with brain sections from wild-type controls. In Fig. 5, two representative cross- and longitudinal-section images of individual vessels and surrounding parenchyma from wild-type and tg6 mice are shown. A thin basement membrane surrounds the endothelial cells that line the vessel walls and surrounding tissue of control (wild-type) mice. In endothelium from tg6 mice, however, very distinct changes in structure show a thicker basal membrane. The endothelial cells display an activated phenotype containing a greater number of organelles, such as mitochondria and transport vesicles, and have multiple luminal protrusions. Thus tg6 mice exhibit distinct morphological alterations in overall blood vessel structure and endothelial cells that are reminiscent of an inflammatory response.
Endothelial activation/dysfunction markers are upregulated by excessive erythrocytosis.
Morphologically, the transgenic endothelium appeared to be activated. To confirm this observation, we performed Western blot analysis for some well-established endothelial activation markers. A representative Western blot analysis for intercellular adhesion molecule-1 (ICAM-1) on cytoplasmic extracts from transgenic and control mice shows increased expression levels in all tg6 samples (Fig. 6A). Quantification of all Western blots for ICAM-1 and vWF is shown in Fig. 6B. ICAM-1 and vWF were significantly upregulated by approximately twofold (P = 0.0045 and P = 0.0338, respectively) in tg6 compared with wild-type mice. These data confirm our electron-microscopic results, indicating ongoing endothelial damage in these mice.
In this study, we have investigated the direct effects of chronic excessive erythrocytosis on brain vascular structure and function with use of a transgenic mouse line in which hypoxia-independent Epo overexpression results in a hematocrit of 0.8–0.9 without alteration of blood pressure, heart rate, or cardiac output. Despite a more than twofold increase in hematocrit levels and blood volume in our mouse model (45), the vascular system appeared to function adequately, such that changes in vessel number, diameter, and morphology did not cause BBB disruption, even after the mice were subjected to an acute hypoxic challenge (8% O2 for 4 h). An increase in tight junction protein expression per vessel presumably contributes to their impermeable state, such that at 4–5 mo of age, the BBB and the microvascular circulation as a whole are adapted to withstand the adverse effects of excessive erythrocytosis.
There are significantly fewer (16%) brain vessels with increased (15%) luminal diameters in tg6 than in wild-type mice. For this reason, we further calculated that these mice should have a 9% reduction in vessel surface area compared with wild-type animals. In other model systems, it has been shown that increased vascular density is related to (low) oxygenation of the surrounding tissues; therefore, reduced vessel density in tg6 mice and the greater number of circulating erythrocytes would imply improved O2 delivery. Thus the following question arises: Is the reduced vessel surface area of these mice due to increased oxygenation? Because it has been difficult to measure the Po2/Pco2 of brain arteries and veins in our mice, our assessment is indirect: HIF-1α is induced in response to cellular hypoxic stress (15) and has been shown to play a pertinent role in proliferation of endothelial cells and capillary formation during hypoxia (43). Protein levels of HIF-1α during hypoxia and its target gene VEGF are reduced in tg6 compared with wild-type controls. This reduced oxidative stress response supports the notion that oxygenation is improved in transgenic mice and may even increase their hypoxic tolerance compared with wild-type mice.
There is substantial evidence that many endothelial functions are sensitive to the presence of reactive oxygen species (ROS) and oxidative stress. Increased ROS levels result in the production of excess oxidants, which overwhelm the scavenging capacity of cellular antioxidant systems; consequently, protective glutathione stores are depleted. Because a direct cross talk between glutathione and ICAM-1 has recently been proposed (20), increased levels of ICAM-1 in tg6 brain imply that antioxidant levels may be decreased. ROS may also reduce local production of protective levels of NO or its bioavailability by reacting and scavenging NO to form peroxynitrite. Indeed, oxidative stress has been shown in many experimental paradigms to result in endothelial damage and dysfunction in vivo (1, 22, 35) and may directly damage the tg6 vasculature. Tg6 brain vascular endothelial cells displayed an activated phenotype with increased basement membrane thickness, denoting augmented deposition of extracellular matrix molecules, both features reminiscent of an inflammatory phenotype. Similar to oxidative stress, inflammation is also important in the development and/or progression of vascular disease and is particularly associated with alterations in the expression of vascular and platelet adhesion molecules, levels of coagulation factors, and activity of oxidants and antioxidants (31, 36). In agreement with this, tg6 brain extracts showed increased expression of ICAM-1 and vWF, well-recognized markers of endothelial activation and damage (27), indicative of an active immune response. These reports confirm our previous observations of significantly increased levels of the endothelium-specific cell adhesion molecule VCAM-1 in tg6 mice (48), alluding to continuous activation and damage of the endothelium. ICAM-1, although not specific to endothelial cells, also plays an important role in immune-mediated cell-cell adhesive interaction and intracellular signal transduction pathways. A strong correlation between induction of ICAM-1 and vascular permeability has been shown in various pathologies, including atherosclerosis, ischemia, human immunodeficiency virus, and autoimmune disorders, suggesting that ICAM-1 mediates regulation of BBB function and structure (13). Although our study did not show increased BBB permeability, it is likely that the elevated ICAM-1 levels are an early indication of imminent loss of BBB integrity. The significantly increased level of endothelium-specific vWF detected in mouse brain extracts further indicates vascular injury and endothelial damage (27) in tg6 brain. Furthermore, elevated vWF levels also facilitate increased platelet adhesion and, thus, can exacerbate endothelial damage (8).
Blood flow may also alter endothelial characteristics. Vascular endothelial cells are constantly subjected to shear stress imposed on them by blood flow, and shear stress may be a critical factor affecting gene expression in endothelial cells during inflammation. Data from in vitro (42) and in vivo (49, 50) studies indicate that low or low-oscillating endothelial shear stress induces molecular and vascular responses that may be instrumental in progression of vascular-related diseases (47). Because shear stress is a function of blood viscosity, blood flow velocity, and vessel diameter, it is very difficult to assess this parameter in capillaries of tg6 mice. Nevertheless, we propose that in our mouse model, normal physiological shear stress that is vasculoprotective and fosters quiescence of the endothelium and vascular wall may be compromised partly as a result of significantly increased hematocrit and, therefore, increased blood viscosity (45), thereby contributing to endothelial damage.
Additionally, blood flow may directly affect endothelial function via stimulation of NO release (17, 44), which mediates vascular relaxation in response to vasoactive substances and shear stress, providing antiproliferative and antithrombotic functions by inhibiting vascular smooth muscle cell proliferation, monocyte adhesion, platelet aggregation, and thrombosis (for a review see Ref. 21). Consistent with these observations, previous work showed that tg6 endothelial NO synthase levels are elevated, resulting in increased vascular NO bioavailability and compensatory vascular dilatation mechanisms (37), and enhanced thrombin-induced NO release may prevent platelet aggregation, cell adhesion, and, in turn, thrombus formation in these mice. On the other hand, NO is known to be proinflammatory at high concentrations (16), causing increased vascular permeability in inflamed tissue, generation of radicals, and induction of inflammatory cytokines (4, 33). Therefore, it is possible that although high NO levels in these animals facilitate beneficial endothelial vasodilatation, bursts of NO production may reach cytotoxic levels (16), with detrimental consequences, as seen after middle cerebral artery occlusion (MCAO) in these mice (48). The production of free radicals associated with NO formation might also sequester monocytes and neutrophils (Mac-1+ cells) and result in increased leukocyte counts, as in tg6 mice (48).
Leukocytes, especially polymorphonuclear neutrophils, also have the ability to cause proteolytic and oxidative damage to vessels via NO release. This was shown by antibody-mediated depletion of these cells in vivo, resulting in reduced infarct volumes after MCAO (23). Moreover, ICAM-1 is essential for integrin-mediated leukocyte adhesion to activated endothelium, and ICAM-1-mediated microvascular failure plays a significant role in ischemia-reperfusion injury (23, 24, 51). The upregulation of ICAM-1 in tg6 mice emphasizes this point and could also help explain the previous negative outcome observed in these mice after MCAO. In the absence of injury, however, because leukocytes express functional Epo receptors (38), Epo may directly interact with and reduce the number of leukocytes and slow the inflammatory response as a whole (39).
Although a detrimental effect of high Epo levels on the vasculature cannot be ruled out, clinically Epo is a very well studied and frequently used compound, and all current evidence suggests that this is unlikely to be the case (for a review see Ref. 28). Thus we hypothesize that changes in the tg6 endothelium are not a direct consequence of chronically elevated Epo levels in these mice but, rather, are due to the detrimental secondary effects of excessive erythrocytosis. The hypothesis that excessive erythrocytosis results in a state of chronic and/or recurrent inflammation and endothelial dysfunction in our mice correlates well with results from clinical studies of polycythemia vera patients, who displayed endothelial dysfunction and perturbation, which might predispose them to arterial disease (11, 31). Thus our data confirm that endothelial damage is indeed associated with polycythemia vera.
In summary, the work presented here demonstrates that chronic excessive erythrocytosis ultimately results in endothelial activation and altered vascular morphological characteristics that are reminiscent of ongoing inflammatory processes. We propose this animal model to study endothelial dysfunction and vascular changes that may play a central role in the development of vascular-related diseases that cause/culminate in high hematocrit levels or are associated with endothelial activation.
This work was supported by grants from EMDO Stiftung and the Swiss National Science Foundation.
We thank Stephan Keller for breeding the tg6 mouse line.
The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
- Copyright © 2006 the American Physiological Society


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How to Create a Mix:
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I'm handing you one "get out of jail free" card, if you misunderstood my feelings for you and didn't mean what you said, but you better use it fast. I'm already hoarse from crying.
Other songs that feel like "Snow White" by The New Pornographers so I can cry bravely by myself on public transportation while still feeling like it's going to be alright.
He was the inspiration behind the caring love interest in my third screenplay. I was going to share it with him after we started talking again, but now, in an ironic twist, he's being a heartless, inexplicable bully.
Just once, he couldn't put me first and make sure I had what I needed to make this work: to feel safe and close and to have a healthy start
Advice: When a girl says she's worried or scared, talk to her and see you can make things better before assuming it's a lack of love
Why did you say you loved me too?
Just when I thought this day couldn't get any worse
I miss snuggling with you in your warm bed
I just wanted us to get our groove back first. What was wrong with talking a few times so I could feel safe again? And then taking our next steps together? I thought he was finally going to be my boyfriend.
I was feeling happy and now everything is awful again. I don't even get a reason
What did I do to deserve this
I got stuck playing Peach in Mario Kart…again
Of course you can reach out to me too. I might get scared sometimes but you still have my heart.


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Fox News hires Navy SEAL who claims to have killed bin Laden
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Fox News has hired Rob O'Neill, the retired Navy SEAL who claims to have shot Osama bin Laden, according to the media publication Capital New York. O'Neill first appeared on Fox News last year to discuss killing bin Laden. Fox News told Capital that O'Neill will be a contributor who "will offer military expertise and analysis…
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Courtney Y.
Cranbourne, Australia, 3160
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I achieved an ATAR of 92.55.
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I normally don't have that much of a reason to be stressed. I just run off of it. Wish there was an off switch but whatevzz. Makes murder easier, I guess.
Album Rating: 4.5Life is weird
Digging: The Used - The Canyon
as opposed to...death?
Death is pretty weird too.
Album Rating: 4.5Why don't you school us about it
Album Rating: 3.5S/T >>>>>
This is so almost as good.
Album Rating: 3.5Doesn't come close.
either way it's pretty impressive for a collection of b-sides
Album Rating: 3.5Ye its p cool, has some of their best material fo sho
I don't really think there are any bad songs here.
Album Rating: 4.5Agreed hard
Album Rating: 5.0There aren't.
Best System for me.
Album Rating: 4.5Shit a 5 I'm proud of you Butters boy
Butter has brought me tears of joy.
Album Rating: 4.5I'm on the floor right now
damn, a 5 is quite the score there.
Album Rating: 4.5What's your rating os
been too long since I heard this, but I reckon a 3.5-4 something.
Album Rating: 3.0I actually 5'd the s/t, I may bump it down eventually... but it's so much fun.
Digging: Baths - Romaplasm
Bands: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z


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Lenovo Mobile Service Center in Sawai Madhopur
Lenovo Mobile Service Center in Sawai Madhopur, Rajasthan – Address, Contact Number are listed below. If you have any problem with your Lenovo mobile, kindly contact the service center officials. There is 1 Lenovo authorized mobile service center in Sawai Madhopur
List of Lenovo Authorized Mobile Service Centers in Sawai Madhopur:
Lenovo mobile service center in Sawai Madhopur
Name: MICROSYSTEM COMPUTER
Address: Suwalka Complex, Opp Gautam Ashram, Bajaria
City: Sawai Madhopur
State: Rajasthan
Pincode: 322001
Contact Number: 9649900300 / 96499003
Email: email@example.com
Working Hours: 9:30 AM to 6:30 PM
Working Days: Monday to Saturday [Sunday Holiday]
Products Serviced: Smartphones
* Call the LENOVO Service Center before planning your visit, to ensure that the service center address is correct and is open for service.
** Please comment below if you find any of the above information incorrect, we will fix it immediately. Thanks in advance


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Possible shooting at Sunrise Mall in Brownsville
Mon, 09 Jan 2012 01:47:18 GMT —
Multiple witnesses are reporting a possible shooting at Sunrise Mall in Brownsville.
Although details are scarce, here is what we're being told by people who were at the scene.
They said around 7:00 p.m. gunshots were heard near Dillard's department store.
Witnesses said Brownsville Police responded quickly and are currently outside of the mall assessing the situation.
Unconfirmed reports from one source close to the incident says one person was shot and transported to a local hospital.
Action 4 News currently has a crew en route to the scene.
We'll bring you additional details as they become available.


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The Dutch government has decided to send a 545-strong police training mission to Afghanistan, 11 months after the last government fell over military deployment there. The three-year mission, announced by Prime Minister Mark Rutte today, will take effect from the middle of this year and will not involve offensive military activities. Parliament still has to vote on the proposal.
The new mission will be based in the northern province of
© Radio Netherlands Worldwide


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#5) Jack Savoretti's Cover of "Ring of Fire" On Greek (Listen to it here.) - This slow, contemplative take on Johnny Cash's classic song was the perfect background music for Casey and Cappie's bittersweet, alcohol-induced reunion, and it went so well with the existential angst of the whole episode.
#4) Dan Out-Blairs Blair On Gossip Girl - Dan and Blair. Blair and Dan. I always thought their relationship consisted solely of a mutual hatred and a shared love for Serena, but I have to admit the combination of their animosity, intelligence, and wit makes for some very amusing television. This week they went head to head while working at the same internship at a fashion magazine, but since Dan knows Blair better than the other interns, he didn't fall victim to her sabotage. For example, when she tried to get him to take their boss the wrong pair of shoes, he told her: "I didn't date Serena van der Woodsen for two years and not come away knowing that those are Marc Jacobs. And they're mustard." Even better was Blair's attempt to distract Dan, when she yelled, "Oh look! It's Georgina's baby!" (Too soon?) But in the end, Blair didn't bring down her full force of wrath on Dan because she promised to fight fair, and it looked like they might almost be something marginally close to friends, until Dan made a preemptive strike to sabotage her instead, not trusting her promise to make it a clean fight. One awkward public scuffle on the floor of a fashion event later and they were both fired. But wait! Dan threw himself under the bus so Blair could keep her dream internship. Maybe Dair isn't over after all...
#3) What Do a Former Nazi, a Six-Hour Erection, and Ed Begley Jr. Have In Common? They Were All Featured In This Week's Episode of Off The Map! - That's right, folks. Ed Begley Jr. plus cast regular Rachelle Lefevre made for two Veronica Mars alumni in one episode for the second week in a row. (Last week Tessa Thompson guest starred.) As long as this show can keep up with the ludicrously random plot threads, continuous Veronica Mars alumni, and juicy/sappy doctor background stories, I will gladly keep watching.
#2) Community Makes Dungeons & Dragons Cool - A show has to be pretty secure with its sense of humor and characters to pull off a stunt like having an entire episode unfold as a role-playing game, and luckily for us, Community is 100% confident in its tone and humor. The highlight was probably Annie (playing the role of "Hector the Well-Endowed") and Abed's (playing a maiden along their path) verbally dictated sex scene (including some hand motions), which ended with Annie--I mean, Hector the Well-Endowed--declaring, "I stroke her hair lovingly and spoon her for the appropriate amount of time before leaving." This prompted Troy (who was taking notes on their encounter) to ask, "How long is that?" This show is amazing.
#1) Michael and Holly Reunited On The Office - We were all wondering when those crazy lovebirds were finally going to get back together, and time was a-tickin' since this is Steve Carell's final season on The Office. I loved how the whole episode led up to their adorable reunion on the rooftop, showing how they think exactly the same. Dwight was particularly amusing once he discovered that Holly could be used as a kind of tracker to find Michael just by following her whims for egg rolls and free stress balls. We all knew Holly and Michael would eventually find their way back to each other.
*Will Forte's guest appearance on Parks & Recreation as a Twilight-obsessed dad who chained himself in Leslie's office in order to get her to put the Twilight books in the Pawnee time capsule.
*Chuck took down Volkoff, got one family member back (his mother), and added a new one (Ellie's new baby) on this week's Chuck. In the words of General Beckman, "Get this man a chopper."
*Watching Jules watch Grayson watch Field of Dreams while crying on Cougar Town. After all, Grayson's tears are Jules' "double rainbow."
*The ultimate douche face-off on The Good Wife: Cary and Blake went toe to toe in this week's episode, and the levels of hostility and testosterone were matched only by the undercurrent of homoeroticism.
*This quote from Angelo on this week's Top Chef: "I wanted to be a fruit stylist, back in the day."


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Spreading 'the good news'
To keep it simple, there are two Americas/AmeriKas. They operate seperately and they overlap.
First, AmeriKa and it's Kulture.
AmeriKa has become a civilization devoid of civilizing factors. Yes, certainly, we have material comforts, consumer utopia and the necessary communications grid to send out messages to the ends of the earth and into space. But what message are we sending?
We have every kind of food you could want. If you had a craving for the intestines of a dog, you could probably find a 'gourmet fusion' restaurant that would serve them up. We have vegans, meat eaters, seafood lovers, vegetarians, you name it. You want Asian, burgers, pizza, kosher, it's all here. Halal, too. We have entire television networks devoted to food. Any appetite can be satisfied.
Music? What do you like: classical, heavy metal, jazz, bluegrass, power pop? It's all readily available: Today we have internet 'radio stations' that cover every 'niche market'.
Technology? We are drowning in it: Flat screen TVs, laptops, Blackberries, cell phones, video cameras, digital cameras. Go to 'Best Buy'.
Videos or TV? We got cable, satellite TV, YouTube, DVDs, NetFlix, We even have some actual movie Theaters left where you can see a film the old fashioned way.
Money? Hell, even with the continuing rumours of economic collapse, we have paper money, plastic money, digital money, gold and silver.
But what does it mean? For the most part it means emptiness.Why? Because, at it's core, what we consider 'mainstream AmeriKan Kulture' is built on a foundation of lies, greed and, yes, ignorance.
In my 40+ years of being aware of the 'bigger picture', I have never seen a more violent or heartless AmeriKa than the one we live in now. Every type of murder, rape and bestiality is commonplace now. This, in our 'Kommunities'. At the top, we are a perpetrator of mass murder and genocide: we are a destroyer of whole cultures. I thought Vietnam was bad, but the criminal actions of AmeriKa in the MidEast and Afghanistan take the proverbial cake. And they are carried out with such an almost apathetic, run of the mill cold-bloodedness, that the mind boggles. A generation nurtured on video games gets to play with real people and from what I can gather sees it all as an extension of 'X-box'.
Pornography is rampant, replacing normal human sexual relations, especially among single men. With the advent of feminism, and the rampant egotism prevalent today, the opposite sex becomes 'objectified'.
The violence and pornography have completely penetrated mainstream entertainment programming, sending occult messaging and imaging to the jaded masses. Worse, children are fed this unholy diet as soon as they can be placed in front of a tube.
Corruption? It is a given, at all levels of he Kulture. For all atheists out there, remember that when God is removed by man from the picture, the center can not hold. Society becomes a case of 'Is that all there is?'
AmeriKans today are, for all our riches and comforts, an ungrateful people who 'want it all NOW!'.
But, there is another America out there, and it is with this America that hope still remains alive.
I see the overlapping 'Americas' from a bird's eye view when I play music, especially when I play it on the street. I meet and talk to the Americans who long for something beautiful, something infused by the Spirit, or, at the very least, something that will break the enveloping greyness of the consumer Kulture. These people are the ones who still have the capacity to turn off the 'white noise' of the Kultural matrix/machine.
I see the same in students, a generation that senses that 'something is not quite right' but can't put their finger on it, completely. But they know enough to want to continue the search, intuitively sensing that things can be better than this. Most of these student are from the liberal arts and humanities, neglected fields of endeavor that have been overwhelmed by the drive to train functionaries for the NWO in 'studies' of business and finance.
I see the other America in the Churches, too. While it may seem that 'God is Dead', and while we watch with disgust the cowardly and corrupt behavior of many religious leaders and janissaries, the heart of Americans still longs for God, but the ears mightily strain to hear His voice because of all the noise.
The one AmeriKa is built on fear. Fear sells, and it is an easy emotion to appeal to, for everyone is scared of something. The other America is still based on faith, hope and charity, the classic virtues. What is in short supply is knowledge and wisdom. These are premium qualities in a time of 'the Big Lie'.
The real America is built on 'grass roots culture' which has many forms. The basis of it is one-to-one communication, building from the ground up. When things get too big, they are invariably doomed. The hollowing out takes place. This is illustrated by the 'Lady Gaga' syndrome, the substitution of trash for civilization. No matter how they may dress it up, they are doomed. Just remember that.
Mystery Babylon will fall, and the people will cry out in wonder. It is always like this.
On to 2011.
'And a child shall lead them...'


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Personalized Icon Gold-Plated Bar Necklace
This is a necklace that will show off more than just her name. It will also display a symbol that evokes what's most central to her identity. For a woman who stands for something, a woman who cares.


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Saint Seiya Omega Episode 21 English Subbed
You are watching Saint Seiya Omega Episode 21 English Subbed from the Saint Seiya Omega Anime Show. Watch or Download Saint Seiya Omega Episode 21 MP4 English Sub and other episodes of Saint Seiya Omega Streamed for Free.
"The Flightless Pegasus! The Journey Back From Defeat!"
Stream Saint Seiya Omega Episode 21
Episode Summary: Eden takes Aria away, and Aquila Yuna and Pegasus Koga resume their journey, demoralized by their failure to protect their friend. Along the way, Yuna and Koga separate, meanwhile Eden and Aria reminisce about the happy days they shared during their childhood. Koga later meets a young man who first mocks his weakness, luring the teen Saint into a fight. Koga later realizes the man to be the owner of an immense Cosmo, and turns out to be Cygnus Hyoga, one of the legendary Saints who protected Earth from great menaces many years ago. Hyoga manages to teach Koga that to reach the true potential of his Cosmo, he must first believe in himself. After learning Hyoga's lesson, Koga rejoins Yuna and both resume their way with renewed resolve.


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Navi Mumbai, Maharashtra India (PressExposure) January 08, 2008 -- Western European Logistics report has been published due to demand from professionals in the supply chain industry for reliable and comprehensive market statistics.
This report provides an analysis of past market performance along with forecast growth trends for logistics markets across seven major European markets in five key sectors.
Sourced from a combination of secondary and unique primary research, this report provides up to date information that delivers in-depth understanding of trends across the European Logistics industry, providing you:
Detailed understanding of market drivers Benchmarking of historic growth rates Identification of future trends Tracking of country / sector performances Business development & planning tools
Use this extensive data and analysis to understand the factors that drive manufacturers and retailers to outsource supply chain activity to specialist logistics service providers. As a supplier or 3PL, this research will enable the identification and targeting of future, potentially high yielding, growth markets and opportunities.
Ideally suited to meet the needs of any professional within the supply chain industry, this focused business intelligence can be used to assess the performance of a market by just about every measure available. Size, growth and outsourcing rates along with each sectors complexity, culture and regional attributes are all considered.
Market size by country Growth rate by country Market value by sector Growth rates by sector Size of the contract logistics market Outsourcing rates by country Outsourcing trends by sector Forecasts to 2011
More importantly, the data contained can be used to draw conclusions that can be applied to either process or strategic planning with the absolute confidence that the data originates from a source that is a consistent, reliable and specialist within the supply chain industry.
This report will therefore assist you in ensuring that you are fully informed, be your need to devise or advise on a strategy, assess a marketâs size and growth potential or simply ascertain its current value. Growth in outsourcing (stimulated by manufacturers and retailers recognizing the benefits to be had from outsourcing) does not necessarily equate to an equivalent growth in the contract logistics market as 3PLâs continue to operate under extreme margin pressures. It is therefore necessary to evaluate your market through specific trends and data points, a task this report will allow you to execute easily.
For more information, please visit : [http://www.bharatbook.com/detail.asp?id=30032]


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Surplus Noun Synonyms: surplusage, overage, excess, leftover(s), surfeit, over-abundance, oversupply, overdose, glut
Surplus Verb Synonyms: excess, leftover, extra, spare, over-abundant, superfluous, unused, redundant
Business / Finance / Statutory Surplus: A merger in which one corporation remains as a legal entity, instead of a new legal entity being formed. MORE
Business / Agriculture / Surplus: The amount by which available supplies are greater than the quantity that will bring producers an adequate income. A surplus may be due to production outrunning demand, a decline in consumption, or a MORE
Business / Agriculture / Restricted-Use Pesticides: A pesticide may be classified for restricted use if it requires special handling because of its toxicity. These may be applied only by trained, certified applicators or those under their direct superv MORE
Life Style / Travel / Restricted Travel Dates: A specified period of time when certain rates, fees, and taxes may apply that are not used during regular business times. MORE
Business / Finance / Restricted Surplus: A portion of retained earnings not allowed by law to be used for the payment of dividends. MORE
Business / Finance / Surplus Funds: An individual or corporation that guarantees the performance or actions of another. MORE


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Saddam warns Iraqi people of major war, but promises to spill U.S. blood
Saddam Hussein was sworn in for seven more years as Iraqi president after an official 100 percent referendum victory.
"I swear by almighty God, my honour and my belief to preserve Iraq's independence and territorial integrity, and to safeguard the republican system and principles of the great July 17 revolution," Saddam said in a ceremony broadcast on Iraqi state television.
The regime's number two Ezzat Ibrahim congratulated the president before the country's political elite.
Saddam went on to make a speech in the packed auditorium in Baghdad. The Iraqi leader accused the US administration of being in thrall of the Zionist lobby.
Saddam urged Iraqis to fight hard if the United States attacked, warning that any invasion would lead to the spilling of American blood.
He added: "The road of blood takes you to more blood and he who tries to shed the blood of others must expect his blood to be spilled."
Saddam told Iraqis that they might find themselves soon faced with a major war. "If God Almighty...decides to put you again to the test in a situation of fighting on a large scale, then the Almighty, the nation and history will expect you to deliver an effective stand...in defense of the homeland...," he said.
"Afterwards, the enemy will fall on its face, despised, condemned and defeated," Saddam said. (Albawaba.com)
© 2002 Al Bawaba (www.albawaba.com)
Top Headlines
- Bush administration plans to prosecute Saddam for ''war crimes''; Experts: U.S. attack may lead to Iraqi coup
- Iraqi officials congratulate Saddam over referendum outcome
- Bush Promises to "Deal" With Saddam As Iraqi Envoy Continues Arab Countries Tour
- Sherif Ali bin al Hussein to Albawaba.com: Prince Hassan not interested in ruling Iraq, Iraqi people to topple Saddam
- Blair to publish evidence ''proving danger posed by Saddam''; Israel to be ready for Iraqi war by November 1


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Katarina Build Guide by veteran of the horde
Not Updated For Current Season
This guide has not yet been updated for the current season. Please keep this in mind while reading. You can see the most recently updated guides on the browse guides page.
Thank You!
Your votes and comments encourage our guide authors to continue
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Katarina Build
Ability Sequence
Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
This guide isnt to tell you exactly how you gona play Katarina is just to tell you some good ideas that worked out for me and might work at out for you too
The defensive part of the mastery is beacuse Katarina is rly fragile so you want to make her live longer and be able to shunpo in the middle of evryone and blow death lotus but you still want to wait for your teamates to go first so they dont go for you since the start.


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First off, the garden and green house are doing good… Plants seem to grow fast here in Alaska, due to the short grow time we have. you can see how they are doing on our gardening page
Work has been crazy, but have had a few days off to go to Chitna and dipnet for fish, and also do a little camping.
We are planning on starting to backpack camp, no more truck camping now the kids are gone.
More later


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