text:
Psychology Tutors in Perry, NY
Find Private & Affordable Psychology Tutoring in the Perry Area!
High School Advanced Regents Degree, Graduated 5th in class at Letchworth Central School SUNY Morrisville, Equine Science (1 year,...
Senior Biology Major (B.S.) at SUNY Geneseo, Minors in Psychology and Mathematics, 2.71 GPA (3.02 in major)
Senior at SUNY Geneseo, Currently working towards B.S in Biology and B.A in Psychology, GPA is 3.15
Sophomore Psychology Major and Spanish Minor at SUNY Geneseo with a GPA of 3.28
Junior Psychology major at SUNY Geneseo
Junior Sociology, Biology Minor at SUNY Geneseo, GPA 3.96, Major GPA 4.0. High School Diploma is advanced regents with honors.
Senior Psychology Major at SUNY Geneseo
Junior Psychology and Philosophy Double Major in the Edgar Fellows Honors Program at SUNY Geneseo
Senior at SUNY Geneseo Psychology Major with Minor in Biology 3.0 GPA
Double major in Business Administration & Communication at SUNY Geneseo
Junior at SUNY Geneseo studying English and French. Associate's Degree in Social Sciences from Jamestown Community College with a 3.94 GPA.
Senior at SUNY Geneseo, graduating in May 2012 with a B.A. in Psychology and a minor in Sociology Overall GPA: 3.81; Psychology GPA: 4.0
Senior English Major at SUNY Geneseo Minors: Communications and Women's Studies GPA: 3.42
Junior, Biology Major at SUNY Geneseo


text:
, Gujarat India (PressExposure) October 18, 2011 -- Do you want affordable structural design services? Do you want to outsource structural engineering design services? Then look no further...
Structural Designing India is one of the most prominent companies who have been providing extraordinary structural design services and structural engineering design services over the years by expert structural detailer.
We have well experienced team of structural detailer and engineers. Our specialty is to complete and fulfill offshore structural design and structural design engineering requirements of our worldwide clients within given time limit with the help of our expert structural detailer. You can email us your requirements at: email@example.com to get a custom quote.
Our professional engineers collaborate with our steel detailers to develop an economical design that can meet your specific needs. We focus on designing a safe structure without compromising your desired aesthetics and function. Structural design services provided by our experts play very important and significant function in structural engineering design services.
We are able to deliver practical and pioneering solutions for complex structural problems with the help of corporate infrastructure and structure design experts. We are committed towards high quality and cost effective product in time. We are using latest structural design software like AutoCAD, Revit Structure, Enercalc, Quick Tools and AutoSketch software to serve quality services to fulfill all requirements of our clients.
Benefits of our outsourcing services are:
High Quality Structural Steel Design services
Lower Your Unit Cost
Increased Design Flexibility
Improved Design Having New Technology Support
High Accuracy in Structure Design and Analysis
Stable and Strengthen Design
Affordable and competitive services
You can get the help of expert detailers
Latest tools and technology
Minimum turn around time
Complete construction documentation of whole project
To know more about structural design services and structural engineering design services please visit us at: http://www.structuraldesigningindia.com

subset: commoncrawl


text:
The Shadow Lounge London, Greater London (Closed)
Europe's Premiere Gay Members Club, located in London's Soho district. www.theshadowlounge.co.uk ****WEEKLY LISTINGS**** MONDAYS: Patrick Lilley presents "IT'S BRITNEY BITCH". Open 10pm -3am. Playing the best in R n B, dance and mixes of your favorite chart hits. DJ Tuomo Fox and others on rotation. Hosted by Kojo Fenty. HAPPY HOUR 50% off house spirits, house wine, beer and discounts on champagne all night. FREE ENTRY TUESDAYS: Its 80's Night - All your Club Classics and Guilty pleasures! read more


text:
We Are
What is the brand all about?
SoulKix is a brand that celebrates the chill, relaxed life while supporting anyone who wants to express who they are by creating their own custom kix.
Why do we exist?
We exist to help the individual stand out from everyone else.
What do we stand for?
Different, acceptance and uniqueness is the new cool! Don't be like the person sitting next to you, stand up and be you!
Target Audience:
Ages 2 – 102. No older! Period. (Sorry Grandma)
What role will we play in peoples' lives?
Our role is to encourage, embrace and share people's differences.
What are our benefits/features of our products and services?
We offer and encourage the customer the ability to put their personality in their footwear.
What qualities do we want to associate with SoulKix?
SoulKix is a fun, unique, different, creative, cause-driven business with stellar customer service.
Our Services
If you are a SnugZ USA promotional distributor, please visit snugzusa.com.
Minimum quantity 10 pair.


text:
Sign In
Sign Out | Hello, null
Browse more:
These soft, smooth, velvety pencils can be mixed and blended to create an infinite spectrum of rich, vibrant colors.
They're ideal for a wide range of drawing styles, from bold contemporary still lifes and portraiture to finely detailed work — fashion illustration, animal portraiture, and landscapes.
The unique formulation is highly blendable and glides smoothly over a wide variety of drawing surfaces. They are acid-free and tested for lightfastness. Pencils are pre-sharpened.
Coloursoft Pencils, Skintone Set of 6
This set includes six specially selected skintone colors that are excellent for portraits and multicultural images, including Cream, Blush Pink, Pink, Ochre, Dark Terra Cotta, and Brown Earth.
Wood Box Set of 72
This beautiful hardwood box set contains the full range of 72 Coloursoft pencils and is a welcome addition to any artist's studio. The box measures 2"H × 16.25"W × 9.6"D (5 cm × 41 cm × 24 cm). Weighs 3.6 lbs (1.6 kg).
Shipping Note — Due to manufacturer distribution restrictions, Derwent products cannot be shipped to addresses outside of North America.
Set of 6
Set of 12
Set of 24
Set of 36
Set of 72
Wood Box Set of 72
® Derwent is a registered trademark.
Gift Idea
Hint — click a thumbnail to enlarge.
Hint — click a thumbnail to enlarge.
(based on 97 reviews)
Ratings Distribution
5 Stars
4 Stars
3 Stars
2 Stars
1 Stars
of respondents would recommend this to a friend.
Reviewed by 97 customers
Displaying reviews 1-10
Back to top
Previous | Next »
I would not buy these pencils again
By Dulcinea
from Grand Rapids, MI
Comments about Derwent Coloursoft Pencils:
This product is supposed to be easily bendable. They are not at all blendable and in fact I tried them side by side with 5 other brands. None of the colored pencils can be blended well. The best choice is to use watercolor pencils dry or pastel pencils.
Bottom Line No, I would not recommend this to a friend
Was this review helpful? Yes / No
- You may also flag this review
I mostly use Prismacolor pencils but LOVE Derwents to!
By Adare
from Rapid City, South Dakota
Derwent pencils are creamier and easier to use than some others.
Bottom Line Yes, I would recommend this to a friend
Very nice pencils.
By Sue
from Cumberland, Maryland
I have been using my Derwent Colorsoft pencils along with my other brands and I find that they do very nicely. I am able to lay down a good deal of pigment without much pressure. The colors blend well and are true to their color name.
(1 of 1 customers found this review helpful)
They are OK
By df
from downingtown, PA
I can do just a well with Blick pencils and the price is better.
(2 of 2 customers found this review helpful)
Derwent Colorsoft Colored Pencils
By Rfuentes419
from Tampa, FL
I only purchased a few of the Colorsoft pencils to just try them out. So far I love the creaminess of these pencils. Definitely will try to purchase a larger set when they are on sale to add to my colored pencil collection.
I would buy this product again & again
By Paul
from Jensen Beach, Florida
I love these
(5 of 5 customers found this review helpful)
Far Better Than Prisma
By MJ
from Maryland
I love these pencils! They have a smooth, creamy texture with strong pigment. The colors blend easily and the pencils are comfortable to hold. They are a bit pricey, but they are worth it and superior to Prismacolor pencils which are rather frustrating as the leads constantly break when I sharpen them. I have not had that issue with these pencils. Highly recommended.
I will recommend Blick to anyone interested in art.
By Dave
from Washington, Illinois
Great service. Nice web site. I will continue using Blick for all my art needs.
Excellent colored pencil
By M
from Louisville, KY
Really do love the creaminess of this pencil! Wish wasn't so pricey, though. I can only afford a couple of them........
(4 of 4 customers found this review helpful)
Very Nice Coloured Pencil!
By ViaVon
from Chicago
I recently decided to test this product as i am building a set of exclusively lightfast pencils and wanted to see how these performed. I was very pleasantly surprised! They blend beautifully, sharpen well and hold their point. In terms of performance, they reminded me of the Luminance. They have some pigments ranges I've not found in other brands which also make them a valuable addition to my lightfast case.I will be purchasing more of these.
Loading item data...
Please allow ADDITIONAL DELIVERY TIME for factory-shipped items.
Click here to view expected shipping dates, or call our Order Dept (800)-828-4548.
Copyright © 2015 Dick Blick Art Materials. All rights reserved.
Your cart is currently empty.
Your cart currently contains N item.
Dick Blick Art Materials · P.O. Box 1267 · Galesburg, IL 61402-1267 · Toll-free Phone (800) 828-4548 International Phone +1-309-343-6181 ext. 5402 · Fax (800) 621-8293
Dick Blick Art Materials®, Blick®, Blick Studio®, and Artists Pick Blick® are registered trademarks ofDick Blick Holdings Inc. © Copyright 1999-2017 Dick Blick Holdings Inc. All rights reserved.


text:
GE Fanuc Intelligent Platforms, a unit of GE Enterprise Solutions, announced the Telum[tm] ASLP11 high performance processor AMC module. With up to 4 GBytes of ECC memory and currently featuring an Intel® Core[tm]2 Duo L7400 1.5GHz CPU (which will be regularly upgraded to take advantage of new processors from Intel), the ASLP11 is a single width, full- or mid-sized AMC processor board and is designed for distributed ATCA/MicroTCA processing applications such as wireless base stations, voice over packet, test and measurement, server blades and other enterprise-wide computing.
"Increasing numbers of customers are drawn to the inherent advantages of the AdvancedTCA and MicroTCA architectures, so the types of applications for which ATCA and MicroTCA are being chosen are becoming more demanding," said Wayne McGee, Global Director of Commercial SBC and Server Product Line Management at GE Fanuc Intelligent Platforms. "The ASLP11 delivers the processing power, memory capacity, functionality and reliability that these applications need, as well as providing a straightforward upgrade path for our ASLP10 customers."
Of special note is that the onboard x8 PCI Express controller and associated FCLKA fabric clock may be configured as either the root controller for a subtending PCI Express subnet or as an end node (target) on a PCI Express subnet. Defined by the host system during power up, this provides customers with superior flexibility and enhanced price/performance as it allows the host system to deploy distributed processing resources to support more sophisticated network applications.
Designed to be more reliable through the use of solder to attach all components to the board – enhancing its resistance to shock and vibration – the ASLP11 is optionally available in an extended temperature variant (-40° C to +55° C) to allow deployment in, for example, exterior locations. The ASLP11 also features an on-board 2 GBytes NAND Flash module which may be optionally upgraded for applications requiring greater memory capacity.
Two Gigabit Ethernet ports and two SATA ports are provided, as are watchdog and temperature sensors, with USB 2.0 ports and a COM serial port optionally available. Supported operating systems include standard distribution Linux® and Carrier Grade Linux.
The Module Management Controller (MMC) on the ASLP11 supports the Intelligent Platform Management Interface (IPMI) v2.0 architecture as defined in the AMC.0 specification and is responsible for power sequencing, hot swap and overall module management. The MMC allows independent platform management between all AMC modules, carrier, power supplies, fans and other accessories in a system. This feature may be used for autonomous monitoring, logging and recovery control functions.
Linux is the registered trademark of Linus Torvalds. Intel is a registered trademark, and Core is a trademark, of Intel Corporation.
About GE Fanuc Intelligent Platforms
GE Fanuc Intelligent Platforms, a joint venture between General Electric (NYSE: GE) and FANUC LTD of Japan, is a high-performance technology company and a global provider of hardware, software, services, expertise and experience in automation and embedded computing, with products employed in virtually every industry, including manufacturing automation, defense, automotive, telecommunications, healthcare and aerospace. GE Fanuc Intelligent Platforms is a worldwide company head-quartered in Charlottesville, VA, and is part of GE Enterprise Solutions.


text:
MOVIE SYNOPSIS [ General Audiences ] Under the direction of Robbie Moffat, Suzanne Kendall heads the cast of this feature film originally of UK, with original script in English (subtitled), whose premiere was scheduled for 2013. You can watch Heckle online on TV cable or theaters with original audio in English at different dates. This film premiered in theaters in 2013.
Rating: 5 by 7 users./
Runtime: 98 minutes
Suzanne Kendall, David Whitney, Emmy Sainsbury, Fiz Marcus, Steve Hay, Dave Florez, Matt Prendergast, Dee Quemby, Howard Corlett, Michael Shephard, Chris Bearne, Francesca De Luca, Victoria Johnston, Peter Quayle and Richard Monist.
Comedy, Drama.
98-minute film (full movie) directed by Robbie Moffat.
The original audio of Heckle has dialogues in Dolby Digital, it was produced in UK.
It premiered in cinemas or television in 2013.
Screenplay written by Mark A.C. Brown.
Robbie Moffat.
This film was produced and / or financed by Palm Tree Distribution.
Stealth Media Group.
Without commercial breaks, the full movie Heckle has a duration of 98 minutes; the official trailer can be watched in streaming on the Internet. You can watch this full movie free in EnglishDolby Digital in movie TV channels, renting the DVD or with VoD services (Video On Demand player, Hulu) and PPV (Pay Per View, Netflix).
See the page of this full movie, Heckle in FULLTV Movies.


text:
The cut-throat underworld of Hatton Garden: Why the district has always been crime magnet
AS NEW details emerge of the massive gem heist in London we reveal why the famous jewellery district has always been a magnet for crime.
Hatton Garden is renowned for its precious wares
Hatton Garden is well known for being the area of London where generations of love-struck young men have gone to buy an engagement ring for their intended.
With more than 50 jewellery shops in the space of a few narrow streets it is the perfect place to browse for the sparkler that will seal the deal.
However when Hatton Garden hit the headlines this week it was not thanks to a lovelorn celebrity being spotted splashing out on a diamond ring but because an enterprising gang of thieves had pulled off the heist of the century.
They broke into the basement vault of Hatton Garden Safe Deposit Ltd and got away with a haul of jewellery, cash and family heirlooms reported to be worth up to £200million.
The daring raid put the spotlight back on the darker side of the area known as Diamond Street.
While the vast majority of jewellers and traders who operate in the Garden are honest, hardworking types, it has long had a minority of shady characters drawn to a world where cash is king.
The proceeds of crime can be converted into precious stones that are easily moved across borders.
It is simplicity itself to melt down stolen jewellery and convert it into gold bullion.
Complex VAT scams can reap millions.
The links between Hatton Garden and the criminal underworld were highlighted in violent fashion in 1998 when one of its diamond merchants, Solly Nahome, was gunned down outside his home in north London.
A hitman pumped four bullets into him before escaping on a waiting motorbike.
It turned out that as well as trading in precious stones Nahome was financial adviser to one of London's most vicious criminal enterprises, the Adams family led by fearsome Terry Adams.
After the gang known as the A Team graduated from protection rackets to armed robbery and then drug running they based themselves in London's gem quarter where they could work closely with the sort of people who were in a good position to launder their ill-gotten millions.
The gem trade appeals to money launderers because, as banking regulations get ever tighter, it is one of the few remaining industries where large cash transactions can be carried out with complete anonymity.
"It is all based on trust so there is no paper trail," money-laundering expert Peter Lilley once said.
"There is an environment of almost complete secrecy and it is a very cash-intensive marketplace.
"These are all things that money launderers find very attractive."
They say diamonds are a girl's best friend but they are also close to the heart of criminals looking to move their assets across borders for the reason that they are much more portable and discreet than gold bullion or cash.
As Lilley says: "It is much easier to put a few thousand pounds in diamonds into a suitcase and take it across a border than it is to do the same thing with the cash equivalent."
At the time of his death Nahome was known to police as an international criminal specialising in fraud and money laundering.
He was said to have met with members of the Adams family three or four times a week and arranged for £25million to be hidden in property deals and offshore accounts.
"Honest dealers work cheek-byjowl with the villains," Hatton Garden jeweller Joel Grunberger told one newspaper in 2003.
Grunberger, who was hired by film director Guy Ritchie to help ensure that his diamond-heist thriller Snatch had the appropriate level of authenticity, added: "I don't mean that they sell to the villains but within the businesses there are unscrupulous people.
"Everyone knows the Brink's-Mat gold haul came to Hatton Garden."
Domestic robbers are not the only category of criminal to exploit the lack of security in the gem trade.
Terrorists have been known to take advantage of it too.
We give our word on deals. You stick by your word. If you don't, you're not considered a gentleman
In 2003 it emerged that one of Osama Bin Laden's top lieutenants had visited Hatton Garden in the run-up to 9/11 to raise funds for Al Qaeda.
Some scams have had more obscure origins.
When Mrs Thatcher came to power in 1979 she inadvertently created what might be called a golden opportunity for fraudsters by scrapping VAT on the purchase of gold coins such as krugerrands.
As VAT not only continued to be imposed on the sale of gold bullion but was raised from 8 per cent to 15 per cent, unscrupulous gold dealers had a field day.
They would buy krugerrands from the banks, melt them down and sell the resulting ingots back to the banks as gold bullion charging 15 per cent VAT in the process - an amount they had no intention of passing on to the taxman.
This meant that on every transaction of £100,000, for example, they would make a profit of £15,000.
As the banks would then legitimately reclaim the 15 per cent VAT they paid out on the purchase of the gold the Exchequer not only lost out on revenue but effectively subsidised the fraud.
Not surprisingly criminal gangs that had previously specialised in the dangerous art of armed robbery leapt on this "white-collar" opportunity and the Garden found itself at the heart of this new criminal industry.
It was too good to last of course.
Customs and Excise got wise to the scam and legislation was passed to plug the loophole.
The only problem was that a new breed of financially savvy fraudsters had been created and when VAT was reimposed on krugerrands they simply sourced their gold sovereigns from the Continent where VAT was low or nonexistent and carried on as before.
It is estimated that frauds of this sort funnelled £1billion of VAT money into criminal hands.
It is all a far cry from the area's roots. Hatton Garden's association with gold and diamond-dealing was established at the end of the 19th century when the South African mining giant De Beers picked London as the base for its sales function.
It was an industry that soon grew to be dominated by Jewish refugees, who arrived in Britain after fleeing pogroms in eastern Europe and later the Nazis.
Formally or informally excluded from other trades and professions many Jewish people gravitated towards the world of gems and precious metals.
Fears of a rise in anti-Semitism also made it an attractive sector.
As one Hatton Garden veteran once put it: "When you're persecuted you need something you can carry. You can't carry a house in your pocket."
Diamond mounter Michael Lynton, 66, told the Jewish Chronicle last year that he reckons 70 per cent of Hatton Garden traders are Jewish.
"Everyone knows everyone," he said.
"We give our word on deals. You stick by your word.
"If you don't, you're not considered a gentleman.
"If we had a load of paperwork there would be complete chaos."
Today, in addition to its jewellery shops, the area boasts more than 300 ancillary enterprises ranging from one-man artisan businesses to companies employing between 10 and 20 people.
Many of them were customers of Hatton Garden Safe Deposit Ltd and this week they will be waiting in trepidation to find out if they are among the victims of the Easter weekend heist.


text:
The Truth About What Happens to Your Body When Flying
Where taking flight once seemed like a magical, wondrous thing when you were 7, now the pains of flying are more taxing than watching security rifle through your cosmetic case: Everything. Hurts. And when you think about the feat of airline travel, it's no wonder our bodies experience such dramatic change. Cabins are pressurized to mimic the altitude of 6000 to 8000 feet—the equivalent of sitting on top of a mountain. Adding to that hours of inactivity and recirculated air (and germs), it's enough to make you want to stay home… almost. Since taking an airplane for work or a destination wedding is practically unavoidable, we've dug into what's really causing your body harm and, more importantly, how to fix it.
You've settled into your seat and planned hours of productivity with your laptop, Wi-Fi, and magazines at the ready. Yet slowly but surely, all willpower fades and you simply want to curl up (as comfortably as you can) and rest your eyes. While feeling drowsy might work in your favor (there's nothing quite like a long midflight nap), here's what is actually happening to your body: At that elevation, the air pressure is much lower than at ground level, causing your blood oxygen levels to take a dive. Cue weariness and fatigue.
Try This: Check if your airline has a Boeing 787. These airplanes are pressurized to resemble a lower altitude, boosting oxygen levels inside the cabin.
Strategies for avoiding jet lag vary, but Jeffrey Sventek, executive director of the Aerospace Medical Association, says the flight path you choose has a big impact. In an interview with Huffington Post, he says people who fly from east to west are less likely to feel fatigued, as the body naturally prefers a circadian cycle that's 25 hours long, instead of 24. Hence "people who fly in (a westerly) direction with regularity have very little problem performing quite well on the West Coast," he says, thanks to hours of extra daylight.
Try This: Download Entrain, a science-backed free app that suggests the best time to seek natural light and darkness during your flight to help sync your body's circadian cycle to the destination.
Traveling for business? Dr. Paulo Alves, chairperson of the Aerospace Medical Association Air Transport Medicine Committee, recommends not trying to adjust to a new time zone. "For executives in short trips, trying to keep the home schedule allows for better alertness," he tells MyDomaine.
If you're guilty of watching movies back-to-back without standing to take a break, you might be causing your ankles to swell. Sitting for prolonged periods can cause blood to collect in your legs and feet. While that usually just results in swelling (ever struggled to take off your boots post-flight?), severe cases escalate to blood clots. If you have an underlying medical condition, Dr. Alves says compression socks could be worthwhile, but recommends talking to your doctor first.
Try This: A few simple exercises go a long way to aid in blood circulation. "Pumping your calf muscles is recommended for most people. This can be accomplished by simple extension, flexion, and rotation feet movement," says Dr. Alves. Researchers from the University of Melbourne recommend doing this once every hour during a flight.
Considering the crowds, lines, and general stress associated with airports, a slight headache may not strike you as odd. But it turns out that niggling pain could be linked to something you have control over: dehydration. Once again, cabin pressure wreaks havoc on your body, this time by drying out your skin and zapping moisture from the air. Mayo Clinic points out that among symptoms like a dry mouth and light-headedness, headaches are a telltale sign of dehydration.
Try This: We know that regularly sipping on water is an easy way to stay hydrated, but the Civil Aviation Authority (CAA) has another suggestion to avoid a headache. According to a spokesperson, booking a flight with fewer passengers means a less humid cabin (and humidity is a known headache trigger). "In the instance of an eight-hour flight in a CD-10 with 265 passengers, the humidity level can rise to 20%; the same flight with only 108 passengers sees this level fall to 2%," they say.
When there's little else to do apart from watching movies and snacking, it can be easy to overindulge on a plane. If you've ever wondered why you binge on high-flavor food midflight, there's a scientific reason. The Fraunhofer Institute served the same gourmet meal in a mock cabin and at a fine dining restaurant. They discovered that while the dish received glowing reviews on ground level, participants who tasted it in the pressurized environment had a different experience. Why? "At 35,000 feet, the first thing that goes is your sense of taste," says Lufthansa's executive chef, Grant Mickels. Our ability to perceive sweet and saltiness can dip by up to 30%.
Try This: Bring your own healthy snacks like nuts or dried fruit so you're less tempted by processed plane food. And try seasoning meals rather than reaching for a second serving.
Catching a cold after a long-haul flight seems to be part of the airline experience. The Wall Street Journal puts the risk of getting sick on a plane at 20% higher than normal while the Journal of Environmental Health Research suggests passengers are 100 times more likely to transmit a cold midair than on the ground. According to a study published in the journal Emerging Infectious Diseases, the hot zone is roughly two seats beside, in front, and behind you.
Try This: If someone in that hot zone is coughing or sneezing, ask the air hostess if you can move to a spare seat. Carry hand wipes to give tray tables, one of the filthiest parts of a plane, a quick once-over.
Changes in air pressure cause gas in the body to expand as much as 25%, according to an Aerospace Medical Association study. The result? Feeling bloated, full, and gassy (urgh!). Now we understand why T-shirts and worn-in jeans are the uniform of frequent fliers.
Try This: Skip the soda. Carbonated drinks like Coke or champagne can contribute to bloating.
During takeoff and landing, the air pressure in the cabin changes faster than the air inside your ears. The result? The dreaded ear pop, a feeling that can be a bit uncomfortable but of course is only temporary.
Try This: There are tons of ways to ease pressure in an instant. MedlinePlus recommends combatting the discomfort by chewing gum, yawning, or slowly inhaling and exhaling while holding your nose.


text:
Improvisation and sketch comedy as theater probably goes back to the times of togas, but it's only in the past half-century or so that the forms have been used, together or separately, for a full-evening's entertainment.
Much of the credit for this, along with the explosion of television, goes to The Second City enterprise in Chicago for its study of the use of improvisation and sketch as theatrical forms. The Blue Group, one of Second City's traveling companies, will perform at Livermore's Bankhead Theater Feb. 23.
Starting with acts like Nichols and May, Alan Arkin and a number of other comic performers now in their 70s or 80s, and moving through the latest casts of "Saturday Night Live," Second City has been responsible for training much of the comic talent in TV sketch shows and comedy films.
None of this famous talent will perform with the show in Livermore. Instead, as the company's publicity says, you will have a chance to see the next generation who will set the comic agenda for the future.
Not that they are raw rookies. Most of the six cast members, Scott Morehead, Adam Peacock, Asher Perlman, Liz Reuss, Marlena Rodriguez and Sarah Shook, have been trained by Second City or graduated from the company's conservatory.
Half the group has been part of Second City at Sea, a number of the seagoing performances that entertain nightly on Norwegian Cruise Lines. And everyone in the group has experience performing with other sketch and improv companies.
Members of the Blue Group will present some classic Second City routines, some newer ones and demonstrate how the company members assemble a successful improvisation, then perform from audience suggestions.
The group performs 8 p.m. at the Bankhead, 2400 First St. in Livermore. Tickets, at $25 to $45, can be reserved at 925-373-6800 or www.livermoreperformingarts.org.
"I LOVE YOU, YOU'RE PERFECT, NOW CHANGE!:" Tri-Valley Repertory Theatre's smash hit from 2010, returns with the same cast, this time to the Village Theatre in Danville, where the company is now staging its smaller musicals.
The show reminds us that the road to happily-ever-after is strewed with rocks and potholes, but, despite all the pothole-pitfalls, it is worth it if you survive. This is a series of songs and skits about the mating game, seen from a variety of ages and viewpoints. It takes a look at dating, marriage, the good and bad of in-laws, newborns, trips in the family car and dating tips for the geriatric set.
And it's a funny show, provided you haven't been whacked on the noggin by one of those rocks in the road to romance in the past couple of weeks. The show starts March 1 and runs at 8 p.m. Fridays and Saturdays and 2 p.m. Sundays through March 16. The Village Theatre is at 233 Front St. in Danville.
Tickets, at $15 to $30, may be reserved at 925-314-3400 or.vendini.com/ticket-software.html?w=3a0ca3e53f750551634f79423b949301&t=tix. Tri-Valley Theater has suggested the play is not suitable for young audiences due to adult language and situations.
Contact Pat Craig at firstname.lastname@example.com.


text:
Man arrested with deer skin worth Rs 15 lakh
Kishanganj: A person has been arrested with deer's skin, worth Rs 15 lakh, by Sashastra Seema Bal (SSB) personnel from Dighal bank checkpost on Indo-Nepal border of Bihar's Kishanganj district, an official said today.
The person has been identified as Jagdish Bharti, a resident of Akaha Vishunpur village of Samastipur district, SSB Assistant Commandant Rajiv Pilot said.
Bharti was arrested and handed over to forest department officials late last evening after a deer's skin worth Rs 15 lakh was found from his possession during search by the SSB jawans, Pilot said.
The person, who looked like a seer (Sadhu), had brought the deer's skin from Nepal but he claimed that someone gifted it to him which he used to sit on during prayers, the officer said.


text:
Sweet and salty, and oh-so-versatile, razor clams seem to be a cross-cultural treat! Some of these dishes are a breeze to pair, while others are a bit more challenging. Let's take a look at what we've got and see what's for dinner.
Photo credit: Cortes de Cima via Flickr/Creative Commons
Portuguese Razor Clam Rigatoni
Wow, talk about starting off on the right foot. Portuguese razor clam rigatoni with spicy linguica sausage! Oh baby, this is right up my alley and while I might be tempted to reach for a Portuguese wine, I think I would have to fall back on a recently tried Spanish white, the 2010 Trascampanas Verdejo Rueda, but most Verdejo would make a fine pairing here.
Pacific Fried Razor Clams
Fried razor clams, man these recipes are tempting! This buttery delight sound addictive and are begging to be washed down with a wine as exotic as the clams. My first choice has to be Txacoli, but seeing as that is frequently my first choice and we don't want this to be an all-Spanish list, a little thought quickly delivers me to a nice dry Riesling! Keller has been on fire lately so his Trocken Von der Fels makes for a perfect match!
Herb-Crusted Razor Clams
A take on clams casino, you say. This sounds very Mad Men meets James Bond to me for some reason. Plenty of fresh herbs here, check, time to whip out that old standby and rock the Sancerre. Something nicely fruity with just enough herb to marry well with my full house of razors casino, Miss Moneypenny. By that I mean Claude Riffault's Sancerre Les Baucauds!
Grilled Razor Clams with Meyer Lemon-Chive Vinaigrette
Grilled razor clams with Meyer lemon and chive vinaigrette? This is definitely a bit of a challenge, since I don't want to be too repetitive (why did I blow my Verdejo with that first dish!). I am fast burning through my great options… or am I? What's that up my sleeve, you ask? Why yes, it is in fact Gruner Veltliner! And it's Schloss Gobelsburg's Steinsetz, what more could you ask for? This has enough mineral cut to highlight the bright, simple flavors of the dish and then blind your attackers. Oh wait, that was the last recipe.
Razor Clam Salad (Goi So Mong Tay)
Now this is a crazy dish, all pickled and spicy and raw. Yowsers. This is going to call for a Superwine! Something with a touch of sweetness and exotic flavor that can stand up to all the powerful ingredients in this dish. I could think of many wines that would work here (guessing!). Though the truth is the more I worked through this the more I realized that I had to be careful not to create a clash of the titans, so I actually ended up with something a bit more mainstream. The Willakenzie Pinot Blanc has just a hint of sweetness to help round things out, plus a nice hint of bitterness that should weave wine and dish together nicely!
Razor Clam Risotto
And now to round out the dishes, one of my absolutely favorite razor clam preparations: risotto! I actually took a look around to see if anyone was serving some razor clam risotto while writing these recommendations, such is my love for the dish. It is freaking insanely good and a dish like this deserves a little local pairing. After reacquainting myself with Soave recently, I have to admit that a fine Soave jumps immediately to mind here. Gini's La Frosca is a great choice and while I might look for one with a few years on it, the 2008 is a fine pick!
Want to learn more?
Check out all six of Hana's razor clam recipes over at WhatsCook.in


text:
Sunny Start
Uploaded by: newenglandlight
Monday February 25, 2013
Bristol, RI (Current Weather Conditions)
Caption: ...but then the clouds moved in and by noon the sun was gone. Most of the snow is gone too!
EXIF Data
Manufacturer: Panasonic
Model: DMC-ZS7
Orientation: top - left
x-Resolution: 180.00
y-Resolution: 180.00
Resolution Unit: Inch
Software: ViewNX 2.0 W
YCbCr Positioning: centered
PRINT Image Matching: 208 bytes undefined data
Compression: JPEG compression
Exposure Time: 1/200 sec.
FNumber: f/4.0
Exposure Program: Landscape mode (for landscape photos with the background in focus)
ISO Speed Ratings: 200
Exif Version: Exif Version 2.21
Components Configuration: Y Cb Cr -
Exposure Bias: 0.00 EV
MaxApertureValue: 3.44 EV (f/3.3)
Metering Mode: Pattern
Light Source: 0
Flash: Flash did not fire, compulsory flash mode.
Focal Length: 4.1 mm
FlashPixVersion: FlashPix Version 1.0
Color Space: Uncalibrated
PixelXDimension: 2560
PixelYDimension: 1920
Sensing Method: One-chip color area sensor
File Source: DSC
Scene Type: 1
Custom Rendered: Custom process
Exposure Mode: Auto exposure
White Balance: Auto white balance
Digital Zoom Ratio: 0.00/0.00
Focal Length In 35mm Film: 25
Scene Capture Type: Standard
Gain Control: Low gain up
Contrast: Normal
Saturation: Normal
Sharpness: Normal


text:
Integral Accounting Enterprise is a SaaS solution and requires no additional hardware for installation.
Integral Accounting Enterprise is designed for small and midsize software companies, consultants, value-add resellers and developers.
Integral Accounting Enterprise is a SaaS-based accounting software system that allows you to perform all standard accounting activities in real time and at any location. The software is multilingual and multi-currency and presents all data in a simple interface that users can easily navigate without extensive training beforehand. With Integral Accounting Enterprise, you have the core functionality and capability to build your own ERP system without enduring extra fees, limitations on customization or other restrictions. The system is built on the .NET and SQL server, making it easy for users to tailor the software for their specific needs.
STFB Inc was founded in 1997 and is headquartered in Florida.


text:
Wessex FM News
£4.9M Traffic Scheme Goes On Show
8:07am 17th October 2013
You can have your say from today on major traffic plans for Dorchester.
The £4.9 million pound scheme is aimed at improving air quality, enhancing the environment and protecting historic buildings in the county town.
The first stage of the proposals could see High West Street and parts of High East Street become One Way, new traffic signals at the junction of Princes Street and Albert Road and some "banned turns" at Great Western Junction.
An Exhibition starts today at Dorchester Library.
The closing date for comments is Monday 18 November.
The scheme is being funded by Dorset County Council, supported by £1million in developer contributions and £500,000 from WDDC.
Sign up for the latest local news direct to your inbox


text:
Major five Gas-Powered String Trimmers
, Posted in: Pets, Author: Admin (July 5, 2017)
Owing to the advancement in engineering, specifically in the globe of movie know-how, there isn't any justification to chop corners when you edit video clips. However, it seems that significantly too many 'professional' organisations do exactly that. It truly is imperative that you be blunt and straightforward below: your films are your message into the general public. They can be essentially performing as your deal with to your audience. An inside examination of simple products for ryobi weed wacker attachments. It doesn't matter no matter whether that encounter takes place to become your staff and you might be organizing on sharing a schooling video clip with them or they transpire to become a board of directors or simply probable clientele; you want someone to edit your video clips for you personally who's not only knowledgeable with regard to the process but who also regards this action as considered one of the most important while in the entire method of filmmaking.
Craftsman has many of the bestselling designs in the market. They have got a 12 inch electric powered lone trimmer 74512 used for light duty process. It's motor powers of three.6 amps powerful. This is often assured light-weight weighted electric powered trimmer which is effortless to maneuver.
Electric powered Powered Weed Whacker: A lot of the weed whackers focus on the electrical offer. They do not call for gasoline or oil to function. These types of electric powered weed eaters are lighter in pounds in addition to come in lesser sizes. They're also straightforward to maneuver. They can be great for smaller lawns or yards because they use a restriction with the electrical power twine. To try and do a bigger size with the lawn, a person should have an extension twine to function the device.
Distinct weeds will need unique types of approaches and equipment to get taken off. Before the weeding system was accomplished by hand. However it was a back-breaking in addition to a tiresome exercising which consumed lots of time and strength. But in due course, technological progress happened as well as in 1971, George Ballas invented the weed eater. This device was operate on gasoline or electrical power and improved the advantage with the gardener.
All the things else may be carried out by by yourself. These areas all alongside one another charge me $108, with delivery. In addition, I needed to get an engine. When you or someone you are aware of has an previous echo weed eater parts, leaf blower, chain noticed or any other garden instrument that has a horizontal crank shaft motor, check out employing that. Even so, I required my echo weed eater elements for your garden, so I went to Lowes and picked up a Troy-Bilt twenty five cc echo weed eater components for $100 (I'm also advertising the remaining around shaft soon after I eliminate the motor on eBay to recoup some fees). Just ensure that the motor you utilize has a centrifugal clutch. Should you you should not know for sure, attempt spinning the end of your echo weed eater pieces. If it spins freely and you never listen to the motor turn over, then it has a clutch.
Ryobi is likewise one of the top manufacturers inside the subject of manufacturing ability tools, out of doors products and extras. You can find a wonderful mixture of innovation and flexibility from the items. You will discover two types from this firm which appear as gasoline and electricity powered weed eaters. The Ryobi Lithium 18 volt-12 inch (product p2002) Weed Eater is cordless and weighs nearly seven. five lbs. In addition it options adjustable upper shaft to fit consumer height, a fold out edge tutorial, and it stays charged 4 times for a longer time to present better results.
Various weeds need distinctive kinds of approaches and applications to be eliminated.Previously the weeding course of action was carried out by hand.Nonetheless it was a back-breaking along with a tiresome physical exercise which eaten lots of time and energy.But in the end, technological improvements took place and in 1971, George Ballas invente d the weed eater.This device was operate on gasoline or electrical power and increased the convenience on the gardener.
The Earthwise ST00015 electrical string trimmer provides a 15-inch chopping swath making use of 0.065-inch diameter line. The device can also be used as an edger. There may be a flip-down guard to keep you from finding hit by particles although employing the trimmer.


text:
Seasonal Holiday Sweets Wholesale
Seasonal holidays are huge events for confectionery retailers. They're sales milestones that cannot be ignored if you want to make the most of all opportunities available to your business. Hancocks can supply your business with all the wholesale sweets necessary to keep your customers satisfied throughout the year, from Christmas and Easter right down to one day events such as Mother's Day, Halloween and Valentine's Day. These occasions might be very different, but at Hancock's we can cater for them all. We offer a huge range of confectionery at competitive wholesale prices, helping you to stock the right confectionery for the right occasion. Supplying the UK confectionery market for more than 50 years, Hancocks can provide you with proven confectionery for every season. Our cash and carry stores are located nationwide, giving you the choice of over 5,000 different varieties of sweets and chocolate, whereas our extensive online shop means seasonal holiday sweets are just a click away. We stock a range of exciting seasonal holiday wholesale sweets, including: Christmas confectionery Halloween themed confectionery Mother's Day confectionery Valentines confectionery Easter sweets and chocolate These popular sweets cover everything from Love Heart Mini Rolls to gummy vampire fangs, mini chocolate eggs and Christmas candy canes. Of course, we also stock a huge range of popular everyday confectionery favourites, such as fudge, toffee, gums and jellies, Haribo and traditional sweets which can complement your seasonal lines perfectly. Offering your customers a good choice of confectionery will encourage them to browse the range, enjoy everyday treats and remember your business when they wish to buy seasonal confectionery. Hancocks is the nation's leading confectionery wholesaler; with such a range of seasonal holiday wholesale sweets, it's easy to see why retailers and event planners keep coming back. With our range of sweets, branded chocolate and own label confectionery, you'll be able to keep your customers happy all year round.
There are no products matching the selection.


text:
The Moto X 2016 is the star of the week apparently, as last week's leak showcasing the Moto X 2016 back panel started the rumor mill down quite an interesting path. Since we reported about the new metal redesign the Moto X 2016 is rumored to come with, a handful of new leaks have surfaced discussing more features that we should expect of the phone and the first Moto X 2016 front-panel has also been leaked in a photo so we can get a better idea of what the upcoming handset will look like.
Last week, I spoke a bout how it would be marvelous to get a look at the Moto X 2016 front, considering the leaked metal back panel looked quite interesting. Yesterday, my wish came true as MobileXPose stumbled upon a photo of the front panel of the Moto X 2016 and shared it with Android fans. We can't tell much about the handset based on the leaked photo, but we can however estimate a few things like its size. Moreover, the source also shared a few particularities about the Moto X 2016 display which suggest that the handset will feature a shatterproof screen similar to the one we've seen on the Droid Turbo 2. Hopefully, this time it will be a real shatterproof screen, not the easily-scratchable panel that was on the Droid Turbo 2 that drew complaints from hundreds of fans.
The shatterproof front panel of the Moto X 2016 bears a few characteristics that help us determine a few of the features the new handset will sport when it is launched. There's a fingerprint scanner on the front under a moto logo, which suggests that the Moto X 2016 like the upcoming Moto G4 and Moto G4 Plus, will sport biometric security. It kinda seems commonplace though, since most other manufacturers have also adopted the technology in their mid-range and flagship offerings. There don't seem to be capacitative keys up front, so the consensus right now is that the Moto X 2016 will feature on-screen buttons, which is something Android users usually enjoy on flagships.
Moreover, there are quite a few cutouts on the Moto X 2016 display, two big ones in each corner, a big speaker slit up top right next to what seems like a camera cutout. It doesn't seem like the handset will feature a flash for the front-camera, but it might come with new audio technology similar to the HTC 10, for example. Renders of the Moto X 2016 showcase the handset with a sleek metal design and magnetic nits on the back panel, which would be two big innovations for Motorola's Moto X line-up of devices. There's not much we can tell about the resolution, but judging by the way the handset is sitting in the palm of the person in the leaked photo, the screen size might be 5.5-inches. There's a possibility that Lenovo will launch both a Moto X 2016 and a Moto X Plus, and right now, they're rumored to be called the Moto X4 and Moto X4 Plus. These variants will differ more in hardware, rather than size and design, though.
Another interesting Moto X 2016 leak suggests that the new handset will go down the modular path treaded already by the LG G5, which sounds like an interesting option for Lenovo. Many say the LG G5 design is a bit bulky, so if the Moto X 2016 renders are accurate and we are looking at a modular smartphone, Moto might have done a better job than LG at making the device user-friendly, future-proof and premium at the same time. The magnetic nits of the back panel are what give away the new feature according to Evan Blass on VentureBeat, the leakster suggesting that there will be a Vector Thin version and a Vertex version of the Moto X 2016. each with different hardware specifications and compatibility with modular back panels that add functionality to the handset.
Unfortunately, information about modules that will be made for the Moto X 2016 is scarce at the moment. We do know that the modules themselves will be called Amps, and the simplest one, a colorful module that doesn't functionality, will be free of charge with a purchase of the Moto X 2016. Nonetheless, we can assume that we'll be getting a battery module to increase battery life of the handset. It's also possible that Motorola will launch another back panel module with a custom camera module. Most likely, the company will launch quite a few different options when it comes to modules and we'll find out more at the Moto G4 launch next week. It's also possible for the Moto X 2016 release date to coincide with the Moto G4 launch, although most rumors suggest an August release date for the flagship handset. Some say we might even see these handsets on June 9 at a Lenovo Tech World event, which would be just as fitting.
Under the hood, not much has changed since we last spoke about the Moto X 2016 specs, rumors suggesting that the Vector Thin model will have a 5.5-inch QuadHD display, Snapdragon 820 CPU, 4 GB RAM, up to 128 GB internal storage, 4000 mAh battery, 16 MP camera with OIS and laser autofocus and of course modular support. The Vertex model will be an inferior build with a 5.5-inch FullHD display, Snapdragon 625 CPU, 3 GB RAM, up to 64 GB internal storage, 3500 mAh battery, 13 MP camera with OIS and laser autofocus and once again, modular support. Differences in design between the Moto X 2016 Vector Thin and Vertex will probably be minimal, the Thin model being a bit thinner, naturally, than the other one.
The Moto X 2016 release is interesting and while we still have to wait to find out more regarding availability and pricing, we're already excited to see the second modular smartphone getting launched in the U.S. Since LG's model isn't doing as well as the company had predicted, Motorola has a chance at impressing those interested in modular design by associating these Amps with a premium design that's supposed to represent the new ideals of the company after the Motorola acquisition.
Latest posts by Viv (see all)
- OnePlus 3 update to OxygenOS 3.2.0 halted due to installation issues - July 6, 2016
- OnePlus 3 launch on June 14 – all you need to know - June 6, 2016
- Google is launching a mid-range Android VR headset next week - May 12, 2016


text:
General Question
What to do to make this haircut much easier on my hair?
Asked by jeremy0207 (202) February 17th, 2014
I am getting ready for a haircut, the barber is not here yet, but I was wondering what would be the best way to make this easier on my hair, I have curly hair, it's pretty long it's like an afro, and I want to know, should I leave it like this and let him cut it, or should I wash it first? It's pretty stiff so I think I should wash it but I am not sure.
Observing members: 0 Composing members: 0
7 Answers
janbb (51324)"Great Answer" (0) Flag as… ¶
filmfann (44532)"Great Answer" (0) Flag as… ¶
gailcalled (54448)"Great Answer" (1) Flag as… ¶
gailcalled (54448)"Great Answer" (0) Flag as… ¶
tobycrabtree (164)"Great Answer" (0) Flag as… ¶
Answer this question
This question is in the General Section. Responses must be helpful and on-topic.
Wow! You've got 847 knowledge matches!Want to see them? Join Fluther!


text:
Can I candidly talk about life lately? I'm at this amazing point in my journey on this earth where I know what I want to do. To have that clarity is a beautiful thing, the rest of the picture is a little more complicated. I've been trying to piece together moments of quiet to get things done, worrying about my babies getting enough of their mama and feeling slightly inadequate all around. One of the worst things for moms and women in general is comparison. The other day I got caught up on some blog reading, which I'll be frank doesn't happen as often as I'd like, and then began a stream of constant inner criticism: "you should be doing things like this" "she looks amazing" "wow, why didn't I think of that?!" You know the drill. I can be paralyzed by those thoughts sometimes.
Sam has been helping me bounce ideas off about what the rest of the year looks like and realistic ways for me to keep a life/work balance. I think that outsourcing some help would probably make the most sense, but it's a big decision. All of this brings me back to marriage and the importance of the "little things." This week Sam has done two things that just really blew my mind and made me evaluate what love and friendship really mean and how to show that to others. Both acts were small and didn't take much time but they filled me with happiness and made me feel truly supported both mentally and physically.
After we got home from the lake sunday night I started scurrying around trying to get ready for monday morning. I made a concerted effort to set up my day and at the very end I got the coffee ready and was so proud of myself for programming it to brew the next morning. Well, at 6:20 pm the coffee began to brew. I wanted to cry. I threw myself a little pity party and got ready for bed. As I was brushing my teeth I heard the coffee grinder. Sam was surprising me with coffee for the morning. He didn't have to do that but he did and it meant a lot.
Tonight I was 1500 steps from making my goal for the challenge and he told me to get up and move while he dictated emails to me and wrote my replies to the first few. I made my goal! It was the first time and it felt so good. He knew I needed that little victory. Hoping to give him some victories this week too. Feeling very thankful for these gifts this week and reminded of the importance of paying attention to them and also being mindful of letting him feel that same love.
These photos are outtakes from our Home Depot shoot. Our photographer, Katie Oblinger, is quite amazing and I almost cried when I saw these photos. She is that talented. Thank you Katie for capturing us so well!! xo
twitter/ facebook/ pinterest/ instagram/ bloglovin'


text:
It's Ada Lovelace day again. Today many hundreds (hopefully a couple of thousand) of bloggers are writing about women in technology to bring visibility to them. Last year I wrote about my wife who is a teacher and who I admire greatly. This year I decided to go old school and write about Grace Hopper. Sure a lot of people will be writing about her. There are a lot of people who admire her and she was a great pioneer in computer science. There is no question that she was an inspiration to me personally.
I met Grace Hopper for the first time while I was an undergraduate student at Taylor University. She came out to the school to give some talks to students and some advice to the computer science faculty. I was impressed from the start. Grace Hopper could tell a story in ways that helped you learn and remember what you learned. Ken Olsen, founder of Digital Equipment Corp and an other impressive computer science pioneer, gave a talk the same year and while I remember being impressed with him I couldn't tell you a thing he said. With Grace Hopper I can.
One analogy she used was horses. She said that for generations people breed larger and larger horses as the need for more pulling power grew. At some point though they just had to give in and hitch up more horses. That was the computers were going to have to go. (This was the early 1970s BTW and multiprocessors were little more than theory). We were going to have to find ways to spread work across multiple computers. And of course she was right and every time I heard people talk about multi-processors, load balancing and the like I thought back on her words years earlier.
Only later did I realize that it wasn't enough to have good ideas but you had to also be able to communicate them. That communication was one of Grace Hopper's gifts. But she was also a tough person to deal with in some cases.
At one company I worked for I ran into someone who was responsible for fielding requests from Grace Hopper's organization at the Pentagon. She may have looked like someone's little old grandma (the nickname her staff called her by) but she could be tough as nails and would not hesitate to throw the weight of the department of Defense into the fray when she wanted something from a vendor who needed her approval to sell to the government. She was relentless in working for standardization of the COBOL language at a time when that was the programming language for line of business applications. I've always been happy that the Navy named a real honest to goodness ship of war after Admiral Hopper. (USS Hopper (DDG-70)) Anything else would not have been fitting.
One last thing, Grace Hopper always said that if anyone who attended one of her lectures ever said they would do something "because we've always done it that way" she should would appear at their side to haunt them. I don't say that myself but when someone else does one person comes to mind – always – Grace Murray Hopper. An American hero, a computer science hero and my personal hero.
BTW my friend and co-worker Hilary Pike has her ALD post on the Springboard blog. She interviewed Microsoft star Sara Ford.
Are you following me on Twitter?


text:
Having Streaming Hair Is Easier
People want their hair to be the most beautiful. Therefore, hey continuously take care of it. They also use supplements to make them look with volume and shape them. But these supplements might damage hair. For example, hair gel might cause hair loss. Yet, many people still use hair gel. But hair loss might cause more serious problems in future. In order to prevent these problems, people use different kind of products.More


text:
At-Home Money Management: Mint.com
If you struggle with basic money management -- or even if you just want more of a visual/comprehensive analysis -- Mint.com is a wonder of a resource. I recently signed up for a free account, for clarity on where my money goes every month and how to better reel in certain areas of spending. Once you've uploaded various account information, Mint allocates categories for all of your debits and charges, showing a spending pie chart, comparing you to other local and national averages, and making suggestions about where you can save more and how to do it (suggesting other accounts that give more interest or money back).
A few readers are already onto Mint and commented on their experiences here. Anyone else have pluses or minuses to share?
Visit Mint.com to learn more.


text:
We have successfully recovered over $900,000,00024/7 CASE REVIEW
Pay Nothing Until We Win Your Case
Have you or someone you love suffered a serious injury? We can help you take your essential next steps. We handle auto accidents, big truck crashes, wrongful death and many other complicated injuries. Our team is available 24/7.
When you've been in a car wreck, you need an experienced lawyer to who knows the law to protect your interests and fight the compensation you deserve.Read More
The Hammer and his team serve victims involved in crashes with trucks and large commercial vehicles in all 50 states. We will take on the big insurance companies.Read More
When somebody you love has died because of negligence or a wrongful act, we will help you seek justice and the compensation you and your family rightfully deserve.Read More
Prepare for the unexpected. Download, print and put this car accident checklist in your vehicle. Protect yourself and your loved ones with these next steps after a crash.Read More
If you've been injured you might not even be sure about what happened or who is responsible.
Click the links below or call us now for help.
When you come to us for help after you or somebody you love has been hurt you are getting the experience and skill of every attorney and legal support professional on our team.
Darryl Isaacs, aka "The Hammer" founded this law firm dedicated to putting the best interests of each and every client first. He is a seasoned personal injury attorney with decades of experience in winning the best possible resolution for people who have been injured by somebody else's negligence or wrongful act. Darryl believes that when somebody suffers a grievous injury which impairs their ability to work and take care of family or other responsibilities, the entire community is also harmed, which can be compared to throwing a stone into a pool of water and watching the ripples expand outwards. He and the entire team at Isaacs & Isaacs are passionately dedicated to protecting victims of car accidents, big truck and commercial vehicle wrecks, wrongful death, workplace injury, bad drugs, nursing home and child abuse.
When you contact our team we will listen to you, answer your questions, and explain how you can recover money damages for your injuries.
I got what I deserved!
When I got into an accident, Isaacs and Isaacs helped me get the money I deserved.
Samantha White - Truck Crash Client
Thanks Darryl Isaacs
I felt very vulnerable after my accident, Darryl Isaacs helped me get through it.
John Abraham - Car Accident Client
They made it easy!
They made it an easy process, I recommend them to anyone in need of an attorney.
Kathryn James - Truck Crash Client
A professional law firm.
Isaacs and Isaacs helped me get through the trying time and collect for my injuries.
George Miller - Car Accident Client
Representatives are available 24 hours a day, 7 days a week. Call 800-800-8888 Now


text:
Play free online games!
Ninja Adventure>
Ninja Mafia War
Ninja Mafia War
Play with your own profile by registering yourself for this fun game. You can also play as guest, but your scores and account will not be saved then.
User name / E-mail address...Password...
Forgot password?
Not all required fields were filled in
User unknown
User name...E-mail address...Password...Password (Once more)...
Username is too short or too long (between 3 and 12 characters)
Passwords too short (minimum of 5 characters) or do not reconcile
No avatar selected
No valid email address
Username or email address already in use
The username is invalid
Ninja Mafia War
What do you think of this game?
Score: - (0 votes)
DescriptionCommand your ninja army and defeat the invading enemies by placing the right units on the battlefield. Make sure you buy the right upgrades when you have collected enough points!
|Scroll and select
|Unleash ninjas
|Unleash ninjas


text:
ㅋㅋㅋㅋㅋㅋSince I have never dated around in middle school I don't know much of it
So even the littlest manners would make my heart flutterㅋㅋ
Simple stuff like telling yourself "ah~ it's cold" and they would close the window
or picking up your pen that rolled far away
or giving food to you, etc.
Am I weird?ㅠㅜㅜㅜㅜㅜㅠ
What makes your heart flutter?
post response:
original post: here
- ㅇㅇ |2016.07.17 09:31
- I wrote this another time in a PANN post. I swithced my seating place once and I was seating around a bunch of guys. One time, I couldn't solve the answer of a question so the guys around me all mobilized to help me understand it. The sexy brains are the coolest guys
- 29615
- ㅇ |2016.07.17 11:12
- I get flustered when guys wear their school uniform and you can see their chest and arms muscles sticking out
- 1964
- ㅇㅇ |2016.07.17 09:50
- My brain is trying to think about something!!!! My brain is losing consciousness
- 1646
- ㅇㅇ |2016.07.17 01:02
- I made my guy friend mad once and he replied "Ahhh I can't even punch you for that!" and pretended to swing his fist at me ㅋㅋ it was quite cute
- 1109
- ㅇㅇ |2016.07.17 11:00
- Our classroom has different levels/floors(?) and my eraser fell several stairs below. I was thinking about going to pick i tup and a guy that I didn't even know caught it with both hands and came up to give it to me....ㅜㅜ I was totally flusteredㅜㅜ Plus he was hella handsome
- 1045


text:
This is something I keep thinking about lately. If you can achieve success in these turbulent times (economic crisis etc.) how much more can you achieve when things improve?What I mean is if you can make a sale here or earn a few decent clicks with your ad sense account or attract decent traffic, or if not on HP but in the outside world you can hold onto a decent job or get a new job or whatever you must be able to do so much more when the economy starts growing again. The very nature of the boom bust cycle is that in time things will boom again and if you can make money or succeed in some other way during the bust part of the cycle just think of how well you could do during the boom times? When any monkey can succeed. I am so thankful for finding HP. Every click in ad sense and every sale with amazon proves to me that as things improve I should be able to do very nicely and I may even be able to claim some small part of that recovery through my efforts now. If you have had any success here since the economic crisis you might want to think about how much more that success will be in economic recovery!
Wow the power of positive thinking eh! I was a little glum about my adsense and amazon earnings, but when you put it in context of a major economic slump where people have really cut back as have companies advertising, then I'm not doing to shabby after all! Thankis for the uplifting post!
Cool! Glad I could spread the joy
What a wonderful way to think. I have had some success with Ad Sense and Amazon-but more so Hub Pages gave me the opportunity to be comfortable sharing my writing. I guess in a way the falling economy helped improve my self confidence and look into new possibilities to find more lasting happiness, within myself rather than within a career. When the economy does start to improve I hope that my success with Amazon or Ad Sense Improves (that would be great!), as long as I can stay on this new path, and not revert back to the person I was when I felt lost in life.(I think I am rambling-and not sure if that had much to do with your original posting.... SORRY )
It's all good. I just thought I would share what has been going on in my head and see what it provokes in others Mission accomplished! At least with you Now who's next?
hee hee -cosette, still in love with your avatar
I'm blushin over here!
Copyright © 2017 HubPages Inc. and respective owners.
Other product and company names shown may be trademarks of their respective owners.
HubPages® is a registered Service Mark of HubPages, Inc.
HubPages and Hubbers (authors) may earn revenue on this page based on affiliate relationships and advertisements with partners including Amazon, Google, and others.
terms of use privacy policy (0.12 sec)


text:
|Home | About | Journals | Submit | Contact Us | Français
The apolipoprotein E (APOE) genotype provides information on the risk of Alzheimer's disease, but the genotyping of patients and their family members has been discouraged. We examined the effect of genotype disclosure in a prospective, randomized, controlled trial.
We randomly assigned 162 asymptomatic adults who had a parent with Alzheimer's disease to receive the results of their own APOE genotyping (disclosure group) or not to receive such results (nondisclosure group). We measured symptoms of anxiety, depression, and test-related distress 6 weeks, 6 months, and 1 year after disclosure or nondisclosure.
There were no significant differences between the two groups in changes in time-averaged measures of anxiety (4.5 in the disclosure group and 4.4 in the nondisclosure group, P = 0.84), depression (8.8 and 8.7, respectively; P = 0.98), or test-related distress (6.9 and 7.5, respectively; P=0.61). Secondary comparisons between the non-disclosure group and a disclosure subgroup of subjects carrying the APOE ε4 allele (which is associated with increased risk) also revealed no significant differences. However, the ε4-negative subgroup had a significantly lower level of test-related distress than did the ε4-positive subgroup (P=0.01). Subjects with clinically meaningful changes in psychological outcomes were distributed evenly among the nondisclosure group and the ε4-positive and ε4-negative subgroups. Baseline scores for anxiety and depression were strongly associated with post-disclosure scores of these measures (P<0.001 for both comparisons).
The disclosure of APOE genotyping results to adult children of patients with Alzheimer's disease did not result in significant short-term psychological risks. Test-related distress was reduced among those who learned that they were APOE ε4–negative. Persons with high levels of emotional distress before undergoing genetic testing were more likely to have emotional difficulties after disclosure. (ClinicalTrials.gov number, NCT00571025.)
Knowledge of the results of genetic-susceptibility testing may cause anxiety, depression, and other types of distress. Nevertheless, gene variants that are associated with risks of common diseases are being rapidly discovered, and genetic testing is now marketed to consumers.1-3 A variant of the gene APOE, which encodes apolipoprotein E, is associated with an increased susceptibility to Alzheimer's disease,4 and we hypothesized that testing for the presence of this gene would be useful for evaluating the effect of genetic-risk assessment.4 By consensus, APOE testing is not currently recommended for asymptomatic persons; a major concern is the emotional effect of risk disclosure.5-8
In the Risk Evaluation and Education for Alzheimer's Disease (REVEAL) study, we hypothesized that persons who learned about their APOE genotype through an education-and-disclosure protocol would not have greater symptoms of anxiety, depression, or test-related distress than those not receiving such information.
We recruited adult children of a living or deceased parent with Alzheimer's disease through self-referral or telephone calls to families in research registries.9 As part of the screening process, we interviewed the subjects and administered standardized tests to evaluate their cognitive ability, academic achievement, and levels of anxiety and depression. We excluded subjects who scored 1.3 SD below norms on the Repeatable Battery for the Assessment of Neuropsychological Status or the Wide Range Achievement Test 3; higher than 20 on the Beck Anxiety Inventory (BAI), which ranges from 0 to 63, with higher scores indicating greater anxiety; or higher than 26 on the Center for Epidemiological Studies Depression Scale (CES-D), which ranges from 0 to 60, with higher scores indicating greater depression. Ancestry was determined by self-report obtained through a multiple-choice question, with the following options: white, American Indian, Asian, black, and Hispanic; we prespecified the designation of "other" in the event that a subject selected more than one option.
The BAI10,11 is a 21-item scale designed to distinguish symptoms of anxiety from those of depression and to be sensitive to change. This test is based on self-reported severity of a given anxiety symptom during the previous week, with a clinical cutoff score of 16 (moderate anxiety). The CES-D12,13 measures depressive symptoms in studies of nonclinical populations, with a clinical cutoff score of 16 to 20.14,15 We estimated that 5-point differences on either the BAI or the CES-D would be a sensitive indicator of clinically meaningful change and that with a sample of 46 persons per group, the study would have a statistical power of 80% to detect this difference on either scale. The Impact of Event Scale (IES) is a 15-item self-report instrument assessing test-related distress16,17 that is commonly used in genetics research. The scores range from 0 to 75, with higher scores indicating greater distress.18-25 A total score of 20 to 40 may indicate significant distress, and a 5-point difference is a conservative measure of clinically meaningful change. We also developed a series of original questions to gauge changes in risk perception, positive and negative effects of the genetic disclosure, and whether the subject would make the same decision again to undergo genetic testing.
The REVEAL study group — an interdisciplinary team of experts in clinical trials, neurology, genetics, genetic counseling, health psychology, biostatistics, and bioethics — designed the study, drawing on surveys conducted with relatives of patients with Alzheimer's disease.26-28 We created risk curves for the disclosure process that were specific for age and sex, showing the lifetime cumulative incidence of Alzheimer's disease and the remaining risk of Alzheimer's disease for each subject (cumulative incidence from current age to the age of 85 years).29
The study was conducted from 2000 through 2003 at sites in Boston, Cleveland, and New York. It was approved by the institutional review board at each center and was coordinated by a board-certified or board-eligible genetic counselor at each site. Informed consent was obtained first by telephone, then in writing (Fig. 1, and the Supplementary Appendix, available with the full text of this article at NEJM.org). A 90-minute, semiscripted group session that was led by the genetic counselor described the limitations of APOE testing, the absence of a medical benefit of such testing, and the format for communication of the risk. All subjects later met individually with the genetic counselor for the drawing of blood samples, which were sent to Athena Diagnostics for APOE genotyping. Subjects were then randomly assigned to receive the genotyping results (the disclosure group) or not to receive the results (the nondisclosure group). Subjects in the nondisclosure group were individually shown two charts: one showing the incidence of Alzheimer's disease in the general population according to age and another showing the sex- and age-specific incidence of the disease among first-degree relatives of patients with Alzheimer's disease.29 Subjects in the disclosure group were shown the same curves with an additional line for their genotype-specific risk (Fig. 1 in the Supplementary Appendix). They also received their lifetime cumulative incidence risk by the age of 85 years. Subjects were told their APOE genotype and were given written reports of their lifetime cumulative incidence risk and remaining incident risk.29
The prespecified primary outcomes were changes in subjects' anxiety and depression symptoms, as measured by the BAI and the CES-D, respectively. The prespecified secondary outcome was test-related distress, as measured by the IES.
We administered the BAI and the CES-D before randomization and 6 weeks, 6 months, and 1 year after disclosure or nondisclosure of risk. We administered the IES at 6 weeks, 6 months, and 1 year. The primary analysis compared the two randomized groups. A secondary analysis compared the subgroup of subjects in the disclosure group who were informed that they carried at least one ε4 allele, which is associated with an increased risk of Alzheimer's disease (the ε4-positive subgroup), with either a subgroup of subjects who were informed that they did not carry an ε4 allele (the ε4-negative subgroup) or with the nondisclosure group.
Throughout the study, genetics counselors monitored all subjects for adverse psychological effects. We created an independent external ethics and safety board to review the protocol, monitor study progress, and establish criteria for the reporting of adverse events to the institutional review board at each site. For example, subjects whose BAI or CES-D scores were more than 16 or increased by more than 15 points were immediately interviewed, with referral as appropriate. The chair of the ethics and safety board reviewed the results annually to screen for adverse or unanticipated events.
We used two-sided t-tests or chi-square tests to compare baseline variables between the two initial randomization groups (the disclosure group and the nondisclosure group) and between the nondisclosure group and the ε4-positive and ε4-negative subgroups. We compared the rate of withdrawal from the study among the groups. Prespecified primary analyses compared scores on the BAI and the CES-D in the disclosure group with those in the nondisclosure group and included data from all time points, with the use of longitudinal analysis of mixed-effects models that were adjusted for age, sex, years of education, time, and baseline outcome score (if available). In the intention-to-treat analysis, missing values were calculated with the Markov chain Monte Carlo method of multiple imputation with the use of PROC MI statistical software, version 9.1 (SAS Institute).
To assess trends over time, we added interaction terms between group and time as covariates to longitudinal models. The model for the primary analysis was also run separately for each time point. This process was repeated for the IES scores. All three outcomes were then examined in the same manner for the two disclosure subgroups and the nondisclosure group. Although the study was not originally powered for equivalence testing, equivalence was demonstrated post hoc when a confidence interval for a group difference did not include 5 points in either direction.30 We examined raw changes in scores on each outcome measure to calculate the percentage of subjects whose changes in scores exceeded clinically significant thresholds (Fig. 3 in the Supplementary Appendix).
Of the subjects who participated in the informational interview and educational session, 61% and 84%, respectively, underwent phlebotomy (Fig. 1). Twelve subjects withdrew from the study after phlebotomy and before randomization, and seven subjects with low neurocognitive scores and two subjects with high depression scores were excluded. The remaining 162 subjects were randomly assigned in a 2:1 ratio to either the disclosure group (111 subjects) or the nondisclosure group (51 subjects) (Table 1).
After randomization, 14 subjects withdrew from the study, citing study-related reasons. Of the variables listed in Table 1, only the baseline BAI score showed a trend toward an association with withdrawal from the study (i.e., those who were less anxious were more likely to withdraw; P=0.07). Some subjects in the nondisclosure group were dissatisfied at not receiving their genotyping results; of these subjects, 8 (16%) withdrew, as did 6 subjects (5%) in the disclosure group (P=0.04). Of the 53 subjects in the ε4-positive subgroup, 3 (6%) withdrew from the study, as did 3 of 58 subjects (5%) in the ε4-negative subgroup. Of the 111 subjects in the disclosure group, 3 (3%) had the ε4/ε4 genotype, 46 (41%) had the ε3/ε4 genotype, 53 (48%) had the ε3/ε3 genotype, 5 (4%) had the ε2/ε3 genotype, and 4 (4%) had the ε2/ε4 genotype; none of the subjects had the ε2/ε2 genotype. Subjects with the ε4/ε4 genotype were given a higher risk estimate13 but were included in the ε4-positive group in analyses. Data that were collected after randomization but before withdrawal were included in the analyses.
For the end points of scores on the BAI and the CES-D, adjusted group means for the disclosure and nondisclosure groups did not differ significantly either with the use of the time-averaged longitudinal model or at any individual time point (Table 2). Changes from baseline in time-averaged scores for anxiety and depression did not differ significantly between the two groups: for the anxiety score, 4.5 in the disclosure group and 4.4 in the nondisclosure group (P=0.84); and for the depression score, 8.8 and 8.7, respectively (P=0.98).
Interaction analyses indicated that between-group differences in scores were stable over time. We designed the prespecified analyses to allow detection of significant differences, and observing none, we then carried out a post hoc analysis for equivalence by examining 95% confidence intervals. All the confidence intervals excluded a difference of 5 points or more for scores on both the BAI (within 3 points) and the CES-D (within 2 points). Post-disclosure scores on the BAI and the CES-D were strongly associated with respective baseline scores on these measures (P<0.001 for both comparisons).
There were no significant differences between the nondisclosure group and the two disclosure subgroups (ε4-positive and ε4-negative) in the overall model on the BAI or the CES-D at any time point (Tables (Tables33 and and4),4), with all 95% confidence intervals excluding a difference of 5 points or more. We observed no significant differences between the nondisclosure group and the ε4-positive group over time using the longitudinal model or at any time point. Adjusted means were very similar to unadjusted means. (Tables show only adjusted means; raw means are shown in Figure 2 in the Supplementary Appendix.)
Adjusted mean IES scores for the disclosure and nondisclosure groups did not differ significantly at any time point or over time (6.9 in the disclosure group and 7.5 in the nondisclosure group, P=0.61). All 95% confidence intervals excluded clinically meaningful differences of 5 points or more, except for the scores at 6 months, which showed a trend toward less distress in the disclosure group. Adjusted IES scores in the ε4-negative subgroup were lower than those in the nondisclosure group at 6 months (P=0.01), with a similar trend over time (P=0.09) (Table 4). A comparison of IES scores in the ε4-negative group with those in the ε4-positive group showed significant differences over time (4.8 in the ε4-negative group vs. 8.5 in the ε4-positive group, P=0.01) and at 6 weeks (P=0.02) and 6 months (P=0.01), with a marginally significant difference at 12 months (P=0.06).
On the IES, we could not demonstrate equivalence to within 5 points with 95% confidence at any time point for comparisons between the non-disclosure group and the ε4-negative subgroup or between the ε4-positive subgroup and the ε4-negative subgroup. A comparison of the nondisclo-sure group with the ε4-positive subgroup showed no significant differences over time or at any time point. A difference of 5 points could be excluded with 95% confidence at 6 months, 12 months, and over time but not at 6 weeks, when scores for distress were higher in the ε4-positive subgroup. The results of all intention-to-treat analyses were similar to the results of analyses that included only subjects for whom scores at all time points were available (data not shown).
There was no significant change in our findings after adjustment for race, years of education, marital status, study site, referral source, family history, caregiver status, or mean age of the affected parent at the onset of disease. Lower overall BAI scores were associated with lower baseline BAI scores (P<0.001) and also with self-referral to the study (P=0.002). Lower overall CES-D scores were associated with lower baseline CES-D scores (P<0.001), with a younger age at the onset of the parent's symptoms of Alzheimer's disease (P=0.003), and with self-referral (P=0.008). Lower overall IES scores were associated with male sex (P=0.01). No other covariates were significantly associated with outcome.
Subjects in the ε4-positive group were more likely than those in either the nondisclosure group or the ε4-negative subgroup to report a high perceived risk and an overall negative effect of learning their genotype (Table 1 in the Supplementary Appendix). This finding suggests that the subjects in the ε4-positive group understood the information they received with respect to risk and that they had some negative feelings about receiving their results. Nevertheless, subjects in the ε4-positive subgroup were no less likely than those in the ε4-negative group to say that they would undergo testing again.
The distributions of changes in scores were similar among the two disclosure subgroups and the overall disclosure group at all time points (Fig. 3 in the Supplementary Appendix). Outcome scores, combined with prespecified safety criteria, triggered an assessment of adverse psychological effects in 13 subjects: 3 in the nondisclosure group, 4 in the ε4-negative subgroup, and 6 in the ε4-positive group (4 with the ε3/ε4 genotype and 2 with the ε4/ε4 genotype). None of the subjects attributed their psychological state to concern about disclosure but instead cited personal events or experiences, such as family illness and jobrelated stress, that were not related to the study.
Subjects who were randomly assigned to undergo risk assessment with APOE disclosure did not have greater anxiety, depression, or test-related distress than those who were assigned to undergo risk assessment without APOE disclosure. Post hoc equivalence within 5 points was demonstrated at all visits over time for all outcomes, with the exception of the 6-month time point for the secondary outcome of the IES score, which showed a trend toward less distress in the disclosure group.
Subjects who learned they were ε4-positive and were therefore at increased risk for Alzheimer's disease showed no more anxiety, depression, or test-related distress than those who did not learn their genotype, although strict equivalence could not be demonstrated for test-related distress at 6 weeks, which reflected, in part, transient test-related distress among ε4-positive subjects at this time point. The comparison of subjects in the ε4-positive subgroup with those in the ε4-negative subgroup revealed significant but not clinically meaningful differences on test-related distress, driven by reduced distress among ε4-negative subjects at 6 months and 12 months. The change in the IES score from baseline to 6 weeks also differed significantly between the ε4-positive subgroup and the ε4-negative subgroup, which we partly attributed to an increase in distress in the ε4-positive group. On all outcome measures, mean scores in the two disclosure subgroups and the overall disclosure group were well below clinical thresholds for concern. Subjects with outcome scores above prespecified safety thresholds were evenly distributed among the nondisclosure group and the ε4-positive and ε4-negative subgroups, and these subjects did not cite genotype disclosure as contributing to their psychological distress.
Additional questions about risk perception and the effect of testing 6 weeks after disclosure suggested that subjects understood that their risk was higher or lower according to their genotype, and they had the expected negative or positive feelings about this news. Thus, subjects were not immune to the negative implications of learning that they had an increased risk, but these feelings were not associated with clinically significant psychological distress.
These data support the psychological safety of disclosing data regarding genetic-counseling protocols to screened adult children of patients with Alzheimer's disease who request such information, despite the frightening nature of the disease and the fact that disclosure has no clear medical benefit. Larger studies that follow subjects for more than 1 year will be required to detect uncommon and long-term effects, such as delayed emotional repercussions and injudicious life decisions.
APOE is the most robust risk marker available for Alzheimer's disease4; it is also associated with impaired memory among persons without dementia31 and with progression to Alzheimer's disease among persons with mild cognitive impairment.32 Surveys33-35 indicate that the public is interested in APOE genotyping and that 15% of primary care physicians who treat patients with Alzheimer's disease have already received requests for genotyping. If APOE genotyping is discovered to predict treatment efficacy or a risk of side effects, the level of interest is likely to increase.
Although visions of personalized medicine suggest that genetic risk markers will empower patients to improve their health through preventive practices and early interventions,36 there is concern that the understanding of risk among both the lay public and medical professionals is exceedingly poor,37 that genetic tests offering probabilistic estimates for risks of common diseases in the absence of a family history or environmental risks may be misunderstood, and that the psychological harm of such misunderstanding may outweigh the benefits, particularly with disorders such as Alzheimer's disease, for which no medical interventions are available.38-40 These concerns are amplified by the recent emergence of companies offering direct-to-consumer genetic testing, with most of them evaluating single-nucleotide polymorphisms that indicate the APOE genotype,1-3 in the absence of guidelines for deciding which associations between genes and disease have sufficient clinical validity and usefulness to justify disclosure and with no gauge of the effect of such disclosure. Caution is thus warranted, and empirical data are valuable.
Our study is limited in that it concerns a single polymorphism that is robustly associated with Alzheimer's disease. In addition, most of the subjects were of fairly homogeneous and similar ancestry. If APOE genotyping had been provided without genetic counseling or to subjects who had no family history of Alzheimer's disease, the results might have been different. In addition, the exclusion of subjects with low neurocognitive scores and high depression scores may have influenced the results. Within these constraints, our results suggest that disclosure of genotyping information provides a benefit to those who are negative for a susceptibility variant and causes transient, modest distress to those with a positive result.
Supported by grants (R01-HG/AG02213, to Dr. Green; and R01-AG09029, to Dr. Farrer) from the Ethical, Legal and Social Implications (ELSI) Branch of the National Human Genome Research Institute and the National Institute on Aging (NIA); by an NIA Mentoring Award (K24 AG027841, to Dr. Green); by a grant (P30-AG13846) from the Boston University Alzheimer's Disease Center; by a grant (M01-RR00533) from the Boston University General Clinical Research Center; and by a grant (P50-HG003391, to Duke University) from the Centers of Excellence in ELSI Research.
Drs. Relkin and Farrer report receiving consulting fees from Smart Genetics, which provided direct-to-consumer APOE genotyping from March 2008 through October 2008, when it ceased operations.
We thank Joe Massaro, Ph.D., Suzanne Hendrix, Ph.D., and Steve Piantadosi, Ph.D, for their helpful comments on the manuscript.
Members of the REVEAL study group are as follows: G. Annas, Boston University School of Medicine, Boston; D. Bhatt, Cleveland Clinic Foundation, Cleveland; B. Biesecker, Johns Hopkins School of Public Health, Baltimore; D. Blacker, Harvard School of Public Health, Boston; E. Cox, Weill Cornell Medical College, New York; K. Christensen, University of Michigan School of Public Health, Ann Arbor; J.G. Davis, Weill Cornell Medical College, New York; G.-A. Fasaye, Howard University, Washington, DC; P. Griffith, Morehouse School of Medicine, Atlanta; S. Hiraki, Boston University School of Medicine, Boston; E. Juengst, Case Western Reserve University School of Medicine, Cleveland; J. Karlawish, University of Pennsylvania School of Bioethics, Philadelphia; E. Linnenbringer, University of Michigan, Ann Arbor; T. Marteau, Kings College, London; E. Neimeister, Weill Cornell Medical College, New York; T. Obisesan, Howard University, Washington, DC; R. Petersen, Mayo Alzheimer's Disease Research Center, Rochester, MN; S. Post, Case Western Reserve University School of Medicine, Cleveland; L. Ravdin, Weill Cornell Medical College, New York; R.P. Reilly, Shriver Center, Waltham, MA; D. Roter, Johns Hopkins Bloomberg School of Public Health, Baltimore; C. Royal, Duke University, Durham, NC; R. Stern, Boston University School of Medicine, Boston; E. Topol, Cleveland Clinic Lerner College of Medicine, Cleveland; W. Uhlmann, University of Michigan, Ann Arbor: M. Williams, Morehouse School of Medicine, Atlanta; L. Wright, Medical College of Georgia, Athens.
No other potential conflict of interest relevant to this article was reported.
G. Annas, Boston University School of Medicine, Boston.
D. Bhatt, Cleveland Clinic Foundation, Cleveland.
B. Biesecker, Johns Hopkins School of Public Health, Baltimore.
D. Blacker, Harvard School of Public Health, Boston.
E. Cox, Weill Cornell Medical College, New York.
K. Christensen, University of Michigan School of Public Health, Ann Arbor.
J.G. Davis, Weill Cornell Medical College, New York.
G.-A. Fasaye, Howard University, Washington, DC.
P. Griffith, Morehouse School of Medicine, Atlanta.
S. Hiraki, Boston University School of Medicine, Boston.
E. Juengst, Case Western Reserve University School of Medicine, Cleveland.
J. Karlawish, University of Pennsylvania School of Bioethics, Philadelphia.
E. Linnenbringer, University of Michigan, Ann Arbor.
T. Marteau, Kings College, London.
E. Neimeister, Weill Cornell Medical College, New York.
T. Obisesan, Howard University, Washington, DC.
R. Petersen, Mayo Alzheimer's Disease Research Center, Rochester, MN.
S. Post, Case Western Reserve University School of Medicine, Cleveland.
L. Ravdin, Weill Cornell Medical College, New York.
R.P. Reilly, Shriver Center, Waltham, MA.
D. Roter, Johns Hopkins Bloomberg School of Public Health, Baltimore.
C. Royal, Duke University, Durham, NC.
R. Stern, Boston University School of Medicine, Boston.
E. Topol, Cleveland Clinic Lerner College of Medicine, Cleveland.
W. Uhlmann, University of Michigan, Ann Arbor.
M. Williams, Morehouse School of Medicine, Atlanta.
L. Wright, Medical College of Georgia, Athens.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text:
Separate names with a comma.
Discussion in 'Sony PlayStation 1 & 2' started by The Composer, Dec 27, 2009.
How can I play PSX backups
on a modded PS2?
Hardmodded? - Most likely just insert the disc. If not, look at instructions from your mod.
Softmodded? - Only works on few models and you need an original ps1 game. Don't know if the size if that game matters. (high TOC...)
Insert the ps1 game, let the ps2 detect that it is a ps1 disc. Then go into uLaunchELF, make sure it stops the drive(maybe you need to change a setting for that). Then swap the disc with your backup. (swap = change disc without the drive knowing) Then select boot disc or what it is called in uLaunchELF. If you see the Playstation logo, you did it correctly. If it freezes there, your model can't run ps1 backups. I know that V8 and earlier won't work for this, and V9 does.
Oh sorry I didnt make myself clear. It has a modchip.
It doesnt recognize PSX backups on CD or PSX backups on DVD either.
At any rate, which is better? use CD for PSX games or DVDs?
Also, is there any thing that I should know before burning the images?
Samething happened to me, I gave up. I know I was missing a step but didn`t want to screw around with it anymore. Something to do with pressing the reset button twice when it boots up?
PSX are smaller in size they will fit on a CD
I don't see how PSX on dvd could ever work on ps2; CD is your only option. Also when your talking about rate I think you mean burn speed-- Slower is ALWAYS better. Else than that to help you more, you could tell us what kind of modchip you have... theres pretty good PSX emulators on PC also that is another solution.
do you have a phat or a slim?
I have a slim moddel with a matrix infinity clon (modbo) chip
You need to do a swap trick with an origanal PS1 game Run Ulaunch 4.4 from usb get it to boot up COGSWAP.ELF put your origanal in get it to read country codes then it will stop and you swap it for your burnt Ps1 disk. You will need to block your 3 sensors 1st is under left rear hinge small grey switch inside the console the others are the brake for disk and front sensor on top of power switch