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Fiora Build Guide by Desseus
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Fiora Build
Ability Sequence
Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Hello and welcome to my jungle Fiora guide, the dance of death! This is only my second build as I dont tend to post on here much except on champions I am passionate about. Fiora as many of you will realised by now is an extreamly strong AD carry, whilst being Melee with her Lunge and maybe a slowing summoner spell or item she can get straight into the fight and stay there for as long as needed. Jungling with her wont be that much different, Her jungle capability is very good and played right can easily force the enemy into an early surrender.
Pros / Cons
Strong AD carry/jungle
Can close into fights easily
Very powerful ultimate
Parry certain attacks such as parrrley
High attack speed with Burst of Speed
Good jungle/survivalability passive
Great synergy with Lifesteal to stay alive
Kills whilst Burst of Speed is active resets its cooldown
No Crowd control abilities
Vulnerable to crowd control when not using your Ultimate
Lack of a proper escape mechanism
Can be squishy unless built to counter it
New champion currently so a popular target
Not the fastest jungler at the start
Failing to kill with Busrt of Speed active puts it on cooldown and can lead to your demise
French Accent loses charm fairly quickly (Especially if your a steriotyipical Brit)
The runes are straight forward jungle runes that are used often.
Greater Mark of Desolation
These are fairly straight forward runes for a jungler as all junglers need some armor pen to deal true damage in the jungle as well as to deal more damage when ganking against champions with armor.
Armor early on to take less damage whilst jungling in order to be able to clear more of it quicker. Not to mention be able to go on a lane and have most of your health with the ability to soak up more AD damage.
Magic Resist to build up per level will increase along with your natural stat gains from leveling to give you more Magic Resist later on in the game when you need it most to soak up AP carry damage.
Extra damage for the jungle to help clear it at a faster pace plus more damage dealt during ganks on lanes early on. I take these over more Armor Pen or Attack Speed for that very reason, not to mention with Burst of Speed on you can hit the cap for Attack speed so no more needed within runes and 15 Armor Pen is enough to do true damage within the jungle and is later accompnied by an armor pen Item such as The Black Cleaver later on in the game to take down champions easily.
The Masteries Should be easy to understand at a first glance, 21/9/0 for both great offensive power to carry that much more and some survivability whilst improving both summoner spells for quicker ghost and gold when using smite.
Havoc Vs Deadliness
Alot of people argue over which is better, looking at the numbers you get 9 AD from deadliness at level 18 and you get 1.5% extra damage from Havoc say you did 1000 damage to a Ezreal overall and killed (A likely story), 1.5% of 1000 is 15, 15 extra damage is all your getting for three points. with Deadliness lets say you did 1000 damage with one ability like your ulti with a ratio of 1:1 so the 9 AD is an extra 9 damage. 6 difference in damage thats all. To be honest there is hardly a difference and with lower ratios Deadliness is even less worth it. The only reason you would get Deadliness was if your going a crit build and getting Lethality for it. That is why I have gone for Havoc, the extra 6 damage ^^.
Summoner Spells
A must need for ALL junglers in my opinion, while there are those who can go without smite still has its uses such as securing baron, dragon, and your buffs from potiental counter jungling. not to mention you can counter jungle yourself with this to take an enemy buff as they are fighting it. Not to mention it can greatly speed up jungling and therefore improves the speed you level early on in the game.
A personal choice for ganking lanes from the bushes. when improved you really pick up speed and can chase down people who try to use flash to escape you, combine this with lunge and you can get into the fight before people have a chance to react. it also doubles as an escape mechanism much needed on Fiora.
Other Choices:
The AD carrys nightmare at times being able to slow and blind a AD carry can lead to their death and your survival. However if you replace Ghost with this you will be missing an escape mechanism.
Another escape mechanism very handy to flash over walls and use the terrain to escape as well as gank.
Can come in handy for backdooring, pushing as well as a possible escape mechanism at times. If for into playing that sort of havoc playstyle thats got the enemy team running all over the map just to gank you then this is for you.
A popular summoner spell like flash, placing a dot to garentee that kill is always handy however on Fiora would not say it is needed too much you can usually chase down and kill anyone once you get yourself rolling. The only reason I would see a Fiora taking it is to counter the likes of Mundo and Trynd.
Unique Skills
Fiora regenerates health over 6 seconds each time she deals damage. Striking champions will cause this effect to stack up to 4 times.A great passive for jungling, this means you can go either cloth and pots or vamp scepter and come out with most of your health at the end of a jungle run.
Fiora dashes forward to strike her target, dealing physical damage. Fiora can perform the dash a second time within a couple seconds at no mana cost. This is what keeps you in the fight and the closest thing to an escape mechanism you get as a standard Fiora, you have to use it on a minion or another champion in order to get out though.
Fiora's Attack Damage is increased. When activated, Fiora parries the next basic attack and reflects magic damage back to the attacker. Works against champions, monsters, and large minions. This is a great ability and one you max first for jungling, increases your damage to clear faster and can parry attacks for you and resend that damage back to the source as magic damage. An absolute gem of an ability when you can rwact quickly enough to use it for everything.
Fiora temporarily gains additional Attack Speed. Each basic attack or Lunge she lands during this time increases her Movement Speed. Killing a champion refreshes the cooldown on Burst of Speed. abit like Yi's ulti due to the fact it resets if you kill with this active, and trust me you want to kill with this all the time. you level this second for high attack speed mid game.
Fiora dashes around the battlefield to deal physical damage to enemy champions. Successive strikes against the same target deal less damage. This is very high damaging even with the damage reduction on the same target. even in a team fight with low health so long as you got lifesteal you can use this and get health back, whilst using this ulti you are untargetable and can avoid CC with it so it really can be used as a ultility as well in that regard and not just to burst champions down (although that is its main purpose).
Skill Sequence
The skill sequence is to speed up jungle times early game and to max dps potiental by the mid. you only take one point in lunge due to its low damage when compared to the increases in attack speed and attack damage from other abilities and max it last. Maxing Riposte give you extra attack damage and my the time its maxed without any attack damage items you can be over 100 AD, along with the ability to parry and two points in burst of speed for attack speed you can quickly become deadly from level 9 onwards if you were not already from level 4 when you start to gank lanes. Burst of speed is maxed second due for the early game focus on jungle but once your team starts to group up you need to give them assistance where possible. Burst of speed with its attack speed and movement speed it can give you it really helps you chase down champions when combined with lunge and get some easy kills mid game.
Creeping / Jungling
For jungling you can go both Vampiric Scepter or cloth armour due to your passive you should do fine. I start at wolves get your AP carry to help burst them down so you can kill the camp, before Blue buff spawns. Bare in mind he needs to NOT kill them or be close enough to leach exp.
Then get them to pull blue buff and you burst it down and kill it with Smite when its low enough. Remember to use Riposte so you can parry blue buff damage.
Next head to the Wraith camp, kill the big one first and use riposte to parry damage.
Head back to the Wolves camp as it will respawn in the next few seconds and kill it again.
Next is Red as your smite should be off cooldown, same as blue just burst down the Lizard with the buff making sure to use smite to kill it and riposte and burst of speed to bring it down quicker.
Last is Double Golem again standard rules apply here.
Now you killed all that you should be level 4 so get lunge and begin to look for lanes in need of assistance and gank some champions to get gold and exp. Head back to the shop if you had not already get boots of speed and am item to make your way towards wriggles then begin to gank all lanes if possible. If not then back to jungling and then Dragon level 6-8 if you feel safe about it and got good communication with mid and bot lane.
Now you can start with either Cloth Armour and health potions or get a Vampiric Scepter choice is yours both work well, personally I at times go Cloth Armour and potions when I think I might be counter jungled and might need a bit more in the ways of healing and survival since you will not have enough attack speed at that time for Vampiric Scepter to be better.
Next your Wriggles an item that is always worth while, attack damage, armour, lifesteal and a free ward you just cannot go wrong with this. Also make sure to pick up boots of speed before you get finish this item to help with ganking on lanes and moving around.
Mercury's Treads or Ionian Boots of Lucidity are next depending on if you need the extra Magic Resist and Tenacity from Merc's. If not the Ionion are good for the cooldown reduction which can help greatly reduce the cooldown on your ultimate as well as burst of speed should you not land a kill when using it.
Phage next but not taking it all the way just yet, a good early item provides a chance to slow with attack damage and health.
The Bloodthirster, the most powerful AD item as when fully stacked it gives 100 AD and 25% lifesteal. A great item for any AD carry and really goes well with Fiora and her ultimate for gaining you life back as mentioned eariler.
Now time for the Frozen Mallet. Even more health and damage than phage and an increase on the chance to slow really helps Fiora keep her targets close to her to burst them down.
Atma's Impaler, armor crit and extra attack damage based on your max health, combining this with Frozen Mallet really amkes Fiora a bit tanky against AD carries at this point and tops her attack damage to over 300. if needed you can get Wit's End before this for the Magic Resist.
Wit's End is a great item for Magic Resist with Fiora as it comes along with even more attack speed. Make note that this item needs to gain stacks for the magic resist to begin going up.
The Black Cleaver is the Armour Pen item of choice for me with Fiora although you could use Last Whisper if you are against a tanky team all with more than 100 armour. Black Cleaver also gives attack speed and attack damage to help nearly hit the cap with burst of speed on. You have to sell Wriggles to get this or any other item depending on if you felt like needing this earlier.
This is just my standard build order for Fiora but there are situations where this may need to change. for example if you are against a high health team then Mandreds Bloodrazor might be better off then Black Cleaver or Wit's End. if you need Magic Resist before Armour then you might consider getting Wit's End before Atma's. this is only a guideline and should not be stuck to like glue.
Thank you in advance for all the feedback and constructive criticism I might receive means a lot to me. Hope you do well with this build as an Jungle Fiora. pPlease if you do send me pictures and will add them to the guide here. As said before only my second build so still go easy...ish ^^. Thank you and good luck.


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National Statistics
Dwelling stock estimates in England: 2012
- From:
- Department for Communities and Local Government
- Part of:
- Dwelling stock (including vacants), House building, and Live tables on dwelling stock (including vacants)
- Published:
- 25 April 2013
- Applies to:
- England (see publications for Northern Ireland, Scotland, and Wales)
Estimate of the number of dwellings in England.
Dwelling stock estimates: 2012 England
Ref: ISBN 9781409838449 PDF, 154KB, 19 pages
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The latest England dwelling stock estimates statistics produced by the Department for Communities and Local Government were released on Thursday 25 April 2013.
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Document information
Published: 25 April 2013


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Yo, this be Reuben. I've been listening to mostly Mars Volta recently, and for good reason, because it's damn amazing music. I reviewed The Bedlam In Goliath and bid it the "Greatest Album of All Time", which might have spoiled the order of this list but oh well, you probably asked for it. The reason I'm doing this list is because after that album my ordering of 'em is hazy, and I'd like to decide a solid order and write some more about this brilliant band. If you don't already know them, they're a mental American prog rock band known for their weirdness along with their insane energy, with Omar Rodriguez Lopez doing all the orgasmic guitar solos and Cedric Bixler Zavala sounding a little bit high-pitch. They're better than they probably sound, trust me. You can listen to what I think is the best song on each album, in fact; I'll put Youtube links on each album art for what I think is the best song on the album. Even Milo (The Pleb) got into 'em. Without further adieu, Imma ranking these Mars Volta albums from worst to best.
Tremulant EP (2002)
Yeah, I'm including this EP, why not. Tremulant EP was the first studio recording by The Mars Volta that got onto a CD, and it's memorable, instrumentally sound, but was recorded at a time when the band were just getting on their feet, when they didn't quite know what they wanted to play. It mixes the unrelenting punk of At the Drive In and the experimental funk prog stuff of The Mars Volta in an intriguing handful of songs, where the progression of the music of At the Drive In to The Mars Volta can be seen through the change in music between Cut That City – a mental punk song – and Eunuch Provocateur – a high energy prog song. This transformation across the sounds between At the Drive In to The Mars Volta was probably intentional, come to think of it, but it just doesn't sound as groovy, refined or vocally impressive as future Volta was going to. It's a shame such an interesting little record is so hard to get hold of nowadays.
Noctourniquet (2012)
The last Volta album, and by far the worst LP by the band, Noctourniquet is still fantastic, just not quite the same incredible music as they were writing in the years prior. It's an album with its flaws, and one that took me about six listens to start loving. Its spacey synth driven sound with Cedric's newly low-pitched vocals along with its removal of Ikey Owens' extreme energy on the keyboards and the new sound drums from Deantoni Parks take a while to get used to. However, I eventually found that Noctourniquet is full of gems: Molochwalker, The Malkin Jewel and Empty Vessels Make the Loudest Sound all stand as Mars Volta greats. The album is a result of Omar taking a different outlook on life after his mother died, as he decided to stop being a bossy arse, basically, and let Cedric do the writing for once, and work on a record more collaboratively. The end result is interesting, as it's radically different to previous Volta, but brings back some punk and some extra funk here and there to make an ultimately brilliant album.
Frances the Mute (2005)
As soon as Cygmund…Vismund Cygnus gets into its swing, you know what you are in for with Frances the Mute. Insane stuff. The Mars Volta knew what they were doing with this record. They were blasting every other mainstream record to the ground and shocking the Billboard 200 with explosive jazz fusion awesomeness never seen or heard before on such a big stage. It's an album full of brilliance from each musician at hand, erupting with energy into a bout of incredible prog rock. For me, unlike many Volta fans, however, I think it is a little let down by some incessant noodling.
Octahedron (2009)
Let's bring it down. Let's bring it waaaay down. Octahedron ain't quite as scary as Frances the Mute, don't worry. The end of an era for The Mars Volta before they changed in the 2010's, Octahedron is a gentle flick compared to most else the band had recorded before it. Nonetheless, it still manages to blast the eardrums with a nice lil' selection of jazzy prog rock goodies ranging from the mental Cotopaxi to the melody driven Halo of Nembutals to the more Frances-y finisher Luciforms – the song containing possibly the best guitar solo of all time. These wondrous masterpieces are set apart by gentle tracks and a couple of fantastic rock songs in Teflon and Desperate Graves, in a soft, refined and immensely enjoyable Volta listen with Cedric's best vocal performance to date, that along with being my first ever Volta album isn't marred at all by noodling.
Amputechture (2006)
Carrying in the foot steps of Frances the Mute, Amputechture sounds like a weird-ass explosion just like its 2005 predecessor. It betters its former, however, with four masterpieces, a selection of some of my favourite songs, in Day of the Baphomets, Tetragrammaton, Meccamputechture and Viscera Eyes. Each song into their own, all four contain relentless and masterful drum beats from Jon Theodore – the best Volta drummer – and ridiculously skilled and constant guitarwork from Omar, who probably got a little too much joy out of by the sounds of it. The saxophones also help, of course, and the atmosphere not too dissimilar to The Bedlam In Goliath also helps. And Juan Alderete and Ikey Owens thought they'd played their best stuff on this record.
De-Loused in the Comatorium (2003)
Completely unorthodox and off-beat, grooving and funking along, De-Loused In the Comatorium comes oh so close to the top spot. The best debut album in history and in my top four albums of all time, De-Loused is full of energy and expert instrumentals to the brim, sounding like the speakers are about to blow up in the overt awesomeness of the record's incredible sound. It's the album with the very best melodies, and its build up and blow up sections are perfectly on point throughout the whole album — and noodling doesn't do anything to mar the experience at all. Masterful six minute+ songs ranging from Roulette Dares (The Haunt Of) to Cicatriz ESP and to Take the Veil Cerpin Taxt all come under the same veil as the best of Amputechture; but it's the songs in between that make De-Loused the consistent and constantly fantastic album it is — and not all mental. The album just makes me smile from start to finish.
The Bedlam In Goliath (2008)
You thought I liked De-Loused! MAN, I love Bedlam. Yeah, De-Loused is a masterpiece, but The Bedlam In Goliath is even better. It absolutely explodes in your face like a jazz funk orgy brought to you by the best prog band. Bursting with energy from every orifice and able to cripple listeners with its unrelenting FUNK, The Bedlam In Goliath is an album no-one is likely to forget – especially with the veil of its creepy story and atmosphere. Twisting and turning in every direction possible, every song is just as much a roller-coaster ride as the one before it – bear with Tourniquet Man, folks. Not without the guest appearances of John Frusciante just when you thought Omar Rodriguez Lopez's masterfulness on his Orgasm Machine 3000 wasn't enough, The Bedlam In Goliath is the Greatest Album of All Time.
Listen to it now.
Bringing redundant opinions for scrollers everywhere,


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BNC-Plug by Ufixt
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As a demon warlock im trying to use the grimmore of service and cast another felguard with one button
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|26 Feb 2014
Windows 7 Ultimate 64 bit
New SSD in laptop can't boot
Hi Everyone,
I have a Dell N5110 laptop and bought a new SSD and installed it in the DVD rom spot using a drive caddy.
The SSD is recognized by the bios and WIndows 7.
Here is how the whole setup looks:
I cloned the C: partition to the SSD (A: ) but the laptop won't boot from the SSD. I made the System reserved partition on the HDD inactive (as I assume the bootloader is there) but then it won't boot at all.
When I insert the WIn7 bootable USB and try to repair it repairs the HDD boot section.
I've seen that I need to disconnect the HDD and then use the WIn7 bootable media to repair but that is not an option. Removing the HDD on this laptop means completely dismantling it, and it is not really mine.
I need to boot from the SSD while the HDD is still in.
Any help is appreciated?
|My System Specs
|26 Feb 2014
Vista x64 / 7 X64
At an admin command prompt:
bcdboot a:\windows /s a:
sel vol c
Close cmd prompt, restart
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text:
|Publication number
|Publication type
|Application number
|Publication date
|Oct 4, 1994
|Filing date
|Jan 13, 1993
|Priority date
|Nov 19, 1990
|Fee status
|Publication number
|Terry M. Haber, Clark B. Foster, William H. Smedley
|Original Assignee
|Habley Medical Technology Corporation
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (10), Non-Patent Citations (5), Referenced by (81), Classifications (21), Legal Events (3)
|External Links: USPTO, USPTO Assignment, Espacenet
This is a division of U.S. patent application Ser. No. 07/741,780, filed Aug. 7, 1991 for MIXING VIAL, the disclosure of which is incorporated by reference, which application is, in turn, a continuation-in-part of U.S. patent application Ser. No. 07/615,610, filed Nov. 19, 1990 for MULTI-CHAMBER VIAL, (now U.S. Pat. No. 5,114,411) the disclosure of which is incorporated by reference.
Safe and effective drug therapy by injection depends not only upon accurate diagnosis, but also on efficient and reliable introduction of the medical substance into the subcutaneous cellular tissue without introducing contaminants or ambient air. The applicable drug or pharmaceutical must first be drawn from the resident container or vial into a syringe before injection. The integrity and features of the vial, therefore, are influential over the overall safety of the injection.
Typically, great care must be taken when a needle cannula of a syringe is used in conjunction with a vial containing a pharmaceutical to be administered to the patient. As the pharmaceutical is drawn out of the container via the needle cannula, precautions must be taken to avoid air being drawn into the syringe. In rigid vials, air must be introduced into the container to fill the void created as the liquid pharmaceutical is withdrawn. This volume of air then becomes susceptible to being mixed with the pharmaceutical or being drawn in through the needle cannula and creating air pockets in the syringe barrel. Catastrophic consequences could result if these air pockets are subsequently injected into the patient along with the liquid pharmaceutical.
Some medical conditions necessitate such a rapid diagnosis and administration of the necessary injection that precautionary measures needed to eliminate air content in the syringe are often compromised. As an example, diagnosis and treatment of acute myocardial infarction requires rapid injection of a thrombolytic agent adjacent to the atherosclerotic plaque in a major epicardial coronary vessel. Minutes, or even seconds, can have profound impact on the treatment of the patient. Thrombolytic agents, such as tissue plasminogen activator (TPA) or streptokinase usually must be injected immediately, while taking the time for necessary precautions needed to prohibit air from becoming entrapped and compromising the drug.
Problems associated with injections are further complicated when the medication to be administered must be stored as two separate component parts, then mixed, prior to injection. Dual chamber vials have been developed to facilitate storage and mixing of these two-component medications. Common examples of multipart medications include medications which must be mixed from a component A, usually a preservative or catalyst, and a component B, which is usually a pharmaceutical. Component A or component B may be in powder or crystalline form instead of liquid form.
Recently, dual chamber vials have been developed which allow an A component and a B component to remain separated in independent chambers within a single package until mixing is desired. The vial allows mixing of the component parts in that same unitary package. In an example of such a device is the MIX-O-VIAL two compartment vial manufactured by the Upjohn Company of Kalamazoo, Mich. This device is a single vial container having two chambers separated by a small stopper. The septum is formed by a plunger-stopper at one end which is used to pressurize the contents of one chamber so to displace a plug lodged in a small orifice separating the two chambers. As the plunger stopper is displaced (by giving it a quarter turn), the plug floats freely into one of the chambers and is used as an agitator to mix the two component parts together. The two components are free to flow between chambers through the connecting orifice and thereby mix together. Although this device is a significant advance in dual chamber vials, the device has least two significant disadvantages. First, once the protective cap is removed, there is nothing to prohibit a user from penetrating the septum with a needle cannula and inadvertently drawing out only one of the component parts separately prior to mixing. Such an event could be extremely hazardous to the health of the patient. Second, even when the two components are properly mixed, when a needle cannula penetrates the septum and draws out the mixed medication, air becomes entrapped in the vial as air enters to replace the removed liquid as the medication is withdrawn. Time consuming precautions must be taken to carefully avoid entrapping air in the syringe and injecting the same into the patient.
The present invention is directed to a multi-chamber vial which provides both protection against inadvertent withdrawal of one of the component parts of the multipart medication prior to mixing, and a mechanism which eliminates entrapment of air in the medication chamber as the medication is withdrawn.
Generally, the invention relates to vials used for containment of medication substances or pharmaceuticals. More specifically, the invention relates to vial which can store pharmaceuticals made from two component parts where there is a desire to keep the two component parts separated until the time necessary to mix the components together. The device has two (or more) chambers separated by a rupturable barrier which keeps the component parts isolated from each other until mixing is desired. The device is made from materials which eliminate the possibility of a needle cannula accessing either component of the pharmaceutical prior to mixing.
When the components are to be mixed, the contents of one chamber are forced into the other chamber by pressurizing the contents of the one chamber. This is preferably accomplished using a telescoping device so the opposite ends of the device are simply pressed together causing fluid pressure to rupture the barrier separating the two chambers. The one chamber could also be in the form of a flexible bag, a bellows or such other structure. The rupturing can be by dislodging a plug or like element, tearing a flexible diaphragm, breaking a solid frangible sealing element, moving a resilient sealing element, or by other means. Once the barrier is ruptured, the component in the one chamber, termed the second or supplemental chamber, is forced into the other chamber, termed the first or mixing chamber, as the device is compressed. The two components are mixed by the resulting turbulence as the mixing chamber fills with the mixed pharmaceutical.
The mixing chamber is a variable volume chamber. This is achieved by making the mixing chamber a piston and tube, preferably a cylinder, arrangement. The piston travels within the cylinder to increase the size of the mixing chamber as the fluid volume grows. The piston continues to travel until both components are within the mixing chamber; at this point, the piston is forced against a removable safety shield covering the upper end of the cylinder. Only when the safety shield is dislodged from its position covering the end of the cylinder is the user permitted access to the contents of the vial through the piston.
The piston serves several functions: it permits the mixing chamber to be a variable volume chamber to permit mixing of two liquid components without the entrainment of air; it serves as the septum to permit user access to the mixed contents of the mixing chamber by a hollow needle; it permits the mixing chamber to automatically lessen its volume as the mixed contents are removed to eliminate the need to introduce air into the chamber and thus reduce risk; it acts to automatically dislodge the safety shield once the contents of the chambers are combined. When mixing a solid and a liquid, the solid being in the mixing chamber, the use of the piston minimizes the amount of air or other gas in the mixing chamber.
The invention can be practiced in a manner which substantially prevents inadvertent mixing of the components. One way to do this is to mount a housing to the cylinder which partially defines the mixing chamber. A housing base is mounted to the receptacle partially defining the supplemental chamber. The housing and housing base are interconnected so that when the vial is in the inactivated condition, an axial force tending to telescope the housing and housing base together, which would result in collapsing the telescoping components, is prevented. Only when the housing and housing base are properly manipulated, such as by twisting the housing and housing base relative to one another so that a radially extending tab carried by the housing base enters an axially extending slot formed in the housing, can the components be telescoped together. This relative rotary motion can be normally restricted through the use of a safety seal or label adhered to both the housing and housing base. Only by breaking the safety seal or label would relative rotary motion between the two elements be possible.
Another safety feature which may be used instead of or in addition to the coupling of the housing and housing base, is a removable antiactivation cap used with the housing. The antiactivation cap and housing are sized so that they are at opposite ends of the vial and abut one another at their leading edges prior to causing the telescopic components to collapse into one another. Only after the antiactivation cap is removed can the components be telescoped into one another. The safety seal or label can also be used to prevent inadvertent or unauthorized removal of the antiactivation cap and plainly signal any such removal of the cap.
Other features and advantages of the invention will appear from the following description in which the preferred embodiments have been set forth in detail in conjunction with the accompanying drawings.
FIG. 1 is a perspective view of a preferred embodiment of the invention fabricated primarily from clear materials and showing the vial in the inactivated or premixed condition.
FIG. 2 is an exploded side view of the device shown in FIG. 1 illustrating the various component parts.
FIG. 3 is a cross-sectional view of the dual chamber vial in the inactivated condition of FIG. 1 showing a first and second chamber separated by a diaphragm.
FIG. 4 shows the device in FIG. 3 being activated with the fluid pressure in the lower chamber tearing the diaphragm and causing turbulent mixing of the two components in the upper chamber with the piston travelling upwards as the upper chamber fills with both components.
FIG. 5 shows the device illustrated in FIG. 4 in the fully activated position with the upper chamber filled with both mixed components and the shield dislodged from the safety position.
FIG. 6 shows the device of FIG. 5 with the shield removed and a needle cannula of a syringe penetrating the piston to withdraw the mixed pharmaceutical.
FIG. 7 shows a cross sectional view of an alternative embodiment of the invention having a diaphragm which includes a plug on a tether, the plug being dislodged from the diaphragm to open a channel allowing the two components to mix in the upper chamber.
FIG. 8 is a cross-sectional view of another alternative embodiment of the invention having a gasket connected to a plug by a perforated diaphragm which, when inserted in an aperture of the cylinder, separates the two chambers.
FIG. 9 is an engaged perspective, partial cross-sectional view of the gasket used in the embodiment illustrated in FIG. 8.
FIG. 10 is an exploded orthographic view of a further alternative embodiment of the vial of FIG. 1.
FIGS. 11A and 11B are side cross-sectional views of the vial of FIG. 10 in the inactivated, telescopically extended condition and the fully activated, telescopically collapsed condition.
FIGS. 12A and 12B are external views of the vials of FIGS. 11A and 11B.
FIG. 13 is an enlarged end view of the safety shield of FIG. 10.
FIG. 14 is an enlarged cross-sectional view of the hinge portion of the housing taken along line 14--14 of FIG. 11A.
Referring the reader to FIGS. 1 and 3, vial 2 includes a cylinder 18, piston 14, and a supplemental container or receptacle 22. Cylinder 18 and receptacle 22 are partially enclosed in housing 4. Housing 4, cylinder 18 and receptacle 22 are fabricated from transparent or translucent materials to allow the user to view the contents of vial 2. Cylinder 18 and receptacle 22 are preferably glass or a pharmaceutically compatible plastic; housing 4 is preferably made of polycarbonate.
Housing 4 is cylindrical in shape and has a pair of expansion slots 6 located 180� apart. Upper surface 8 of housing 4 has a plurality of gripping slots 10 to provide a non-slip surface for the user. A removable shield 30 is connected to housing 4 in a recessed housing aperture 28. Shield 30 is preferably a one-piece molded part with housing 4 and is connected to housing 4 by a continuous frangible connection 32. Alternatively, shield 30, as suggested in FIG. 13, could be friction fit or otherwise secured within the housing aperture 28. In either event, it is desired that shield 30 also keep the air space 55 above piston 14 sterile. Catch 40 is formed on the inner surface of housing 4. The function of catch 40 will be explained more fully below.
Referring now to FIG. 2, vial 2 is shown in an exploded view from the side showing the component parts. Housing 4 is open at its lower end 12. Cylinder 18 has a first end 17 and a second end 19. Piston 14 includes sealing ridges 16 sized to sealingly engage cylinder 18. Diaphragm 20 is made to be disposed about second end 19 of cylinder 18 and has sealing ridges 21 to create an air and liquid tight seal between outer surface of cylinder 18 and the inner surface of supplemental receptacle 22. Receptacle 22 is formed having a floor 26 and a rim 24. Rim 24 is formed to engage between a catch 36 and a protrusion 38 formed on housing 4 when in the premixed condition of FIGS. 1 and 3 or to engage with catch 40 on housing 4 when in the activated condition of FIG. 5.
Referring now to FIG. 3, showing vial 2 in the assembled and premixed condition, cylinder 18 is disposed between the upper surface 8 of housing 4 and receptacle 22. Housing 4 has a shoulder 34 and a seat 42 which is affixed to first end 17 of cylinder 18, such as by friction fit. Shield 30, frangibly connected to shoulder 34 at 32, covers the first end 17 of cylinder 18. Shield 30 is made of a rigid material which prohibits penetration by a needle cannula. As such, when shield 30 covers first end 17 of cylinder 18, a needle cannula cannot penetrate piston 14. Second end 19 of cylinder 18 is also precluded from penetration by a needle cannula in that it is enclosed by receptacle 22. Receptacle 22 is also made of a needle resistant material. In the preferred embodiment, housing 4 and receptacle 22 are transparent, but shield 30 is colored on it outer surface, preferably bright red, to indicate that access to cylinder 18 is restricted.
When piston 14 is disposed in cylinder 18 and diaphragm 20 is disposed on second end 19 of cylinder 18, an airtight and liquid-tight first chamber 56 is formed within cylinder 18. Diaphragm 20 seals between cylinder 18 and the inner surface of receptacle 22 such that when receptacle 22 is secured within housing 4 with rim 24 between catch 36 and protrusion 38, a second chamber 54 is formed between diaphragm 20 and floor 26 of receptacle 22. As shown in the cross section of FIG. 3, the result is a dual chamber vial 2 having a first chamber 56 housing a first component, and a second chamber 54 housing a second component when vial 2 is in the premixed condition. Airspace 55 is formed between shield 30 and a flat surface 46 of piston 14.
In the embodiment shown in FIG. 3, diaphragm 20 is formed having a cavity 48 forming a thin, reduced-strength membrane 50. The dimensions of membrane 50 are such that diaphragm 20 can be ruptured or torn at membrane 50 by sufficient fluid pressure as will be more fully described below.
Referring now to FIG. 4, vial 2 is shown being activated as it is compressed from the premixed condition. As previously stated, vial 2 in the premixed condition shown in FIG. 3, isolates components in the first chamber 56 from the components contained in second chamber 54. Separation of the two components may be desirable for shipping and storage. When it is necessary to combine the two components, the user grasps vial 2 by placing a finger against upper surface 8 of housing 4 and a second finger or thumb 58 against the outer surface of floor 26 of receptacle 22. The user then squeezes his or her two fingers 60, 58 together as indicated by arrows 62, 64. The resultant compression forces pressurizes the component located in second chamber 54 as receptacle 22 slides up within housing 4.
Initially, vial 2 is taken out of the premixed condition as rim 24 slides up and over protrusion 38. As rim 24 slides over protrusion 38, housing 4 is allowed to expand because of expansion slots 6. In the preferred embodiment, second chamber 54 is initially filled with a liquid component. As receptacle 22 slides up into housing 4 towards first end 17 of cylinder 18, fluid pressure in second chamber 54 increases. The increase in fluid pressure causes thin membrane 50 of diaphragm 20 to rupture, thereby providing a channel 68 between second chamber 54 and first chamber 56.
The user continues to assert compression force 62, 64 forcing the fluid contents of second chamber 54 through channel 68 and into first chamber 56 where the contents of second chamber 54 and first chamber 56 turbulently mix as indicated by arrows 66. As the components mix in first chamber 56, the fluid volume of chamber 56 increases proportionally. The increase in volume in chamber 56 drives piston 14 up in cylinder 18 towards shield 30 as indicated by arrow 76. Air in air space 55 escapes between the rim at first end 17 of cylinder 18 and seat 42; a grooved air path or a one-way valve (to ensure sterility) may be provided if desired. Only when the contents of second chamber 54 are completely exhausted into first chamber 56 is piston 14 driven against shield 30 into a post-mixed condition illustrated in FIG. 5.
The post-mixed condition of vial 2, as shown in FIG. 5, is achieved when receptacle 22 is fully driven within housing 4 and the component parts of second chamber 54 and first chamber 56 have been turbulently mixed and combined within first chamber 56. When the increase in volume in first chamber 56 drives piston 14 into shield 30, shield 30 is dislodged from housing 4 by an audible snap. The audible snap is produced by breaking of the frangible connections between shield 30 and housing 4. Alternatively, when shield 30 is positioned within housing aperture 28 via a friction fit, as suggested in the embodiment of FIG. 13, audible pop as shield 30 is dislodged from its friction fit within housing aperture 28 may also be created. An aural indication is also created when rim 24 passes over catch 40. The user thus has an aural indication when shield 30 is dislodged from housing 4. This aural indicator, in conjunction with the freeing of shield 30, indicates to the user that the contents are fully mixed within the variable volume first chamber 56. Vial 2 is retained in the post-mixed condition by catch 40 retaining rim 24 of receptacle 22.
Once in the post-mixed condition, the shield 30 can be removed and a needle cannula 78 can be inserted through piston 14, which acts as a septum, as indicated in FIG. 6. Syringe 80 can now be used to draw out the contents of variable volume mixing region 56 located in vial 2. An important aspect of the invention is that as the contents of variable volume mixing region 56 is withdrawn from vial 2 through needle cannula 78, the fluid volume of variable volume region 56 decreases. As the volume decreases, the airtight and fluid-tight seals formed between piston 14 and cylinder 18, in combination with the seal formed by diaphragm 20 between receptacle 22 and cylinder 18, drives piston 14 down cylinder 18 towards second end 19 by hydraulic suction and prevents any ambient air from becoming entrained in variable volume region 56. This feature substantially prevents any inadvertent air bubbles from gathering within the pharmaceutical withdrawn from vial 2.
An alternative embodiment of the invention is shown in FIG. 7. In the alternative embodiment, diaphragm 82 has an opening 84 which is sealed by plug 86 in the premixed condition. Plug 86 may be connected to diaphragm 82 using tether 88. Plug 86 may also be a separate component as well. When vial 2a is activated from the premixed condition to the post-mixed condition, the increase in fluid pressure in second chamber 54 causes plug 86 to dislodge from opening 84 allowing the components to mix in first chamber 56 as previously described. This embodiment has the added feature that plug 86 can be used to additionally mix the components combined in first chamber 56 when the user forcibly shakes vial 2a causing plug 86 to work as an agitator.
A second alternative embodiment of the invention is illustrated in FIGS. 8 and 9. In the second alternative embodiment of the invention, cylinder 18b is formed having second end 19b with a small aperture 101. Gasket 92 seals between cylinder 18b and receptacle 22. Gasket 92 is more fully depicted in FIG. 9. Gasket 92 is formed having a plurality of holes 94 formed through a membrane 95 to which a stem 104 of plug 96 extends. Plug 96 is positionable in aperture 101 to seal and isolate first chamber 56 and second chamber 54 in the premixed position. When vial 2b is moved from the premixed position, fluid pressure in second chamber 54 causes plug 96 to be dislodged from aperture 101 forming a channel 110 between first chamber 56 and second chamber 54.
A further embodiment of the invention is shown in FIGS. 10-14. Vial 202 is similar to vial 2 and includes a housing 204 which mounts to the end 206 of a cylinder 208. This is achieved by positioning end 206 of cylinder 208 against a complementary mating surface 210 formed within housing 204. End 206 is preferably mounted to surface 210 using an adhesive or through a snug fit.
Cylinder 208 includes a diaphragm assembly 212 mounted to a second end 214 of cylinder 208. Diaphragm assembly 212 includes an elastomeric sealing element 216 and a pharmaceutically inert insert 218, preferably PTFE, commonly sold as Teflon�. Element 216 has external sealing ridges 220, 222 which engage the inner surface 224 of a cup-shaped receptacle 226. Receptacle 226 is preferably a cup-shaped glass container and is housed within a plastic protective housing 227. Protective housing 227, with receptacle 226 therein, is sized to fit closely but slidingly within housing 204 as shown in FIG. 11A.
Cylinder 208 includes an elastomeric piston 228 sized to move within the interior 230 of cylinder 208. Cylinder 208, piston 228 and diaphragm assembly 212 define a first, mixing chamber 232 which contains a first component. In the disclosed embodiment first, mixing chamber 232 houses a liquid; it could, however, house a dry or lyophilized component as well. A second, supplemental chamber 234 is defined by receptacle 226 and diaphragm assembly 212. Chamber 234 contains a flowable component, preferably liquid, which, upon activation of vial 202, flows into first, mixing chamber 232 so to mix with the first component for subsequent use.
Vial 202 has a tamper-evident seal 236 adhered to the outer surface 238 of housing 204 and the outer surface 240 of an antiactivation cap 242 mounted over the protruding end 244 of protective housing 227. Note that housing 204 and antiactivation cap 242 meet or abut at position 246. Thus, with cap 242 in place, an axial compression force on vial 202 would be resisted by housing 204 and cap 242 and not transferred to cylinder 208 and receptacle 226. After seal 236 is either broken or removed, cap 242 can be removed to permit access to protective housing 227.
Protective housing 227 has three equally spaced radially outwardly extending tabs 248 which engage three axially extending slots 250 formed in housing 204. Each slot 250 includes an offset region 252 at an end adjacent position 246. With vial 202 in the inactivated condition of FIGS. 11A and 12A, radial tabs 248 are positioned in offset regions 252. To permit vial 202 to move from the inactivated condition of FIGS. 11A and 12A to the fully activated condition of FIGS. 11B and 12B, protective housing 227 is rotated in the direction of arrow 254 to move tab 248 from region 252 and into alignment with the main portion 256 of slot 250. The user then presses on the ends of vial 202 causing mushroom-shaped plug portion 258 of sealing element 216 to dislodge from inert insert 218 to permit fluid flow from second chamber 234, through a central opening 260 formed within insert 218, and through several holes 262 formed in element 216 and surrounding plug portion 258. The resulting flow is sufficiently turbulent to ensure appropriate mixing within first, mixing chamber 232.
While this occurs, piston 228 moves within interior 230 towards a safety shield 266 which is positioned adjacent end 206 of cylinder 208. Safety shield 266, shown also in FIG. 13, includes pivot pegs 268 positioned within receptacles 270, see FIG. 14, formed in housing 204. As seen in FIGS. 12A and 12B, unlike safety shield 30 of vial 2, safety shield 266 remains attached to housing 204 when vial 202 is in its fully actuated condition. Although safety shield 266 is pivotally attached to housing 204, safety shield 266 could be an integral part of the housing with an integrally molded hinge and one or more frangible connections to keep the safety shield in position prior to activation.
Surface 272 has several slightly raised projections 274. This helps to prevent piston 228 from lying flush against elastomeric sealing element 216. Also, surface 272 is slightly concave so that as the user draws the mixed contents from chamber 232 (see FIG. 6), thus causing piston 228 to move towards sealing element 216, any liquid around the periphery of piston 228 during the final portions of such a movement will tend to be squeezed inwardly towards the center, thus being more accessible to the needle.
Once in the fully activated condition of FIGS. 11B and 12B, a rearwardly facing (that is, away from safety shield 266) abutment surface 276 formed by protective housing 227 engages a forwardly facing abutment surface 278 formed by housing 204 to substantially prevent separation of housing 204 and protective housing 227. This helps prevent the reuse of vial 202.
Other modifications and variations can be made to the disclosed embodiments without departing from the subject of the invention as defined in the following claims. For example, although the contents of the second chamber will generally always be a liquid, the contents of the first chamber, before mixing, can be a liquid, a slurry or a solid. The opening at the second end of the cylinder could be through the sidewall of the cylinder. The housings are quite useful but optional. If the housings are not used, the removable shield can be mounted directly within the interior of the cylinder adjacent its first end. This would, however, typically require some provision to permit air with an air space 55 to escape when moving from the premixed condition of FIG. 3 to the post-mixed condition of FIG. 5 while maintaining the interior of cylinder 18 sterile. This could be accomplished, for example, through the use of a one-way valve. The mixed pharmaceutical could be accessed in ways other than by piercing the elastomeric piston, such as by removing the piston or by removing a threaded plug formed within the piston.
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|Becton Dickinson And Company
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|Sep 5, 2000
|Baxter International Inc.
|Vial connecting device for a sliding reconstitution device for a diluent container
|Dec 4, 1997
|Dec 12, 2000
|Fowles; Thomas A.
|Sliding reconstitution device with seal
|Aug 4, 1997
|Jan 2, 2001
|Becton Dickinson France, S.A.
|Resealable vial with connector assembly having a membrane and pusher
|Dec 6, 1999
|Feb 20, 2001
|Becton, Dickinson And Company
|Vial transferset and method
|Oct 20, 1999
|Apr 3, 2001
|Becton, Dickinson And Company
|Transfer set for vials and medical containers
|Sep 25, 1997
|Apr 10, 2001
|Becton Dickinson France, S.A.
|Method and apparatus for fixing a connector assembly onto a vial
|Jun 7, 2001
|Apr 30, 2002
|Becton Dickinson And Company
|Vial transferset and method
|Oct 20, 1999
|Apr 30, 2002
|Becton Dickinson And Company
|Transferset for vials and other medical containers
|Oct 8, 1998
|May 7, 2002
|Becton Dickinson And Company
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|Jan 23, 2001
|Jun 3, 2003
|Becton Dickinson France S.A.
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|May 2, 2000
|Jun 24, 2003
|Thomas A. Fowles
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|Becton Dickinson France S.A.
|Transfer set
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|Michael R. Anderson
|Dispensing capsule for a liquid container
|Sep 20, 2000
|Jan 27, 2004
|Becton, Dickinson And Company
|Resealable medical transfer set
|Apr 24, 2001
|Jun 14, 2005
|Becton, Dickinson And Company
|Method of sealing a cartridge or other medical container with a plastic closure
|Nov 26, 2003
|Sep 20, 2005
|Becton, Dickinson And Company
|Resealable medical transfer set
|Jan 29, 2002
|Oct 25, 2005
|Becton, Dickinson And Company
|Transfer set
|Apr 1, 2004
|Feb 14, 2006
|Ing. Erich Pfeiffer Gmbh
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|Alza Corporation
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|The Government Of The United States Of America,
|Mixing vial
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|Oct 1, 2009
|Ivan Heutschi
|Injection device with simplified stopper retention
|Aug 9, 2007
|Jan 28, 2010
|Helou Jr Elie
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|Dec 13, 2006
|Feb 4, 2010
|Lee Jeong-Min
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|Nov 10, 2008
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|U.S. Classification
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|Lapse for failure to pay maintenance fees
|Dec 15, 1998
|Expired due to failure to pay maintenance fee
Effective date: 19981004


text:
Phase II Study of Weekly Topotecan With Bevacizumab in Platinum Resistant Recurrent Ovarian, Fallopian Tube and Primary Peritoneal Cancers
This study is designed as a Phase 2 study. There are no published data on the toxicity of
the combination of bevacizumab and topotecan therapy. Based on data combining bevacizumab
with other chemotherapy agents in non-gynecologic solid tumors, it is not likely that the
toxicity of the combination of the two drugs will be greater than the individual toxicities
of each drug. The toxicities of each of these agents is quite different. Specifically the
toxicity of this combination will be studied using the dose of bevacizumab used in previous
phase II studies of ovarian cancer, e.g. an equivalent of 5 mg/kg weekly with treatments
given at least every 3 weeks. In our study, since topotecan will be given weeks 1,2 and 3 of
an every 4 week cycle, it is convenient to give bevacizumab 10 mg/kg IV every other week.
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Progression Free Survival
Kathryn McGonigle, MD
Principal Investigator
Virginia Mason Medical Center
United States: Food and Drug Administration
June 2006
|Virginia Mason Medical Center
|Seattle, Washington 98111
|Puget Sound Oncology Consortium (PSOC)
|Seattle, Washington


text:
EMILY BOURKE: More than 100 veterans made the journey from Australia for the unveiling of the Bomber Command memorial in London.
Ninety-one-year-old Murray Maxton and his brother, Eric, who's 88 came from Albany, in Western Australia.
They spent their war years flying together, and told Lisa Millar they couldn't believe they'd been able to make the trip to see their courage and the bravery and the sacrifice of their crew mates honoured.
MURRAY MAXTON: He's younger than me. I was the pilot and he was the wireless operator.
LISA MILLAR: You flew on the same plane?
ERIC MAXTON: The same plane, yup.
LISA MILLAR: How many missions did you do together?
ERIC MAXTON: Thirty.
MURRAY MAXTON: Around 30. We started on July the 7th, 1944. We bombed Cannes. The German army was holding up the allies in their advance so they called in the bombers to bomb them and then we done several French targets but most of our targets were down the Rouen, you know, Stuttgart, Mannheim, Issoudun …
ERIC MAXTON: Wasn't (inaudible)
LISA MILLAR: How old were you both at the time?
MURRAY MAXTON: I was 21 and he was 18.
ERIC MAXTON: No, I wouldn't be sworn. I was 20 and he was about 22.
LISA MILLAR: That must have been extraordinary to have the two brothers there…
ERIC MAXTON: Yeah, it was good. Yeah, yeah we …
MURRAY MAXTON: We flew from 460 Squadron and Group Captain Hugh Edwards, he was a VC, he was a West Australian and he let us fly together as long as we didn't tell our parents and they never knew until the war was over.
ERIC MAXTON: Yeah, 'til we got back to Australia they didn't know we'd flown together.
MURRAY MAXTON: We went within a second of death. Mr Smit 110 (phonetic) hit us one night and blew half the aircraft away and...
ERIC MAXTON: Oh yeah, we had some hairy dos. You never had time to think about it. You just went and did it.
MURRAY MAXTON: We had a marvellous crew. All the Australians except the engineer and he come from…
ERIC MAXTON: He was a Geordie. Took him a month to understand him and that was hairy.
LISA MILLAR: So what does it mean for the two of you to be here together?
ERIC MAXTON: Oh, it was the icing on the cake as far as our life is concerned.
MURRAY MAXTON: Oh yeah, for sure, yeah.
ERIC MAXTON: Marvellous.
MURRAY MAXTON: Yes, marvellous.
ERIC MAXTON: Absolutely fantastic.
MURRAY MAXTON: Yeah wonderful. Yeah, for all those young men that lost their lives so that we could be here today, you know, so we'd have the freedom that we got.
LISA MILLAR: Did you two use to tease each other on those missions as well?
MURRAY MAXTON: Oh, we had a lot of fun.
LISA MILLAR: It must have been a great solace to have your brother with you in those terrible times.
ERIC MAXTON: Oh for sure it was, yeah, but I mean I had to sort of look after him.
MURRAY MAXTON: Yeah, but it was a big decision to make at the time you know, because...
ERIC MAXTON: We had to look after each other, you know.
MURRAY MAXTON: You had fun somebody else, well, you might have got shot down.
ERIC MAXTON: Yeah.
MURRAY MAXTON: But we trained very hard, I'd done a lot of fighter affiliation and we done cross country's at night-time and I knew that it only had to be a lucky shot that would get me. I just as good as any German flyer, yeah so, we got away all right.
LISA MILLAR: That's what it came down to, luck?
MURRAY MAXTON: That's right.
ERIC MAXTON: About luck, yeah, yeah, luck.
MURRAY MAXTON: I never thought of dying. I was invincible at that stage and…
ERIC MAXTON: No, never thought of it.
EMILY BOURKE: Two of the Australian Bomber Command veterans, Murray Maxton and his brother, Eric, speaking to our correspondent Lisa Millar in London.
The full story...
Australian veterans join Bomber Command commemoration
Lisa Millar reported this story on Friday, June 29, 2012 12:38:00
EMILY BOURKE: More than 100 veterans made the journey from Australia for the unveiling of the Bomber Command memorial in London.


text:
What can anyone possibly want on a hot summer day? I can tell you--an awesome, ice cold dessert! Sprout and I spent the morning at the park yesterday, and we both were famished--I completed a 5 mile walk, and she spent an hour chasing imaginary cats around the playground with other toddlers. So, we hit the local grocery store and headed home, dreaming up all the things … [Read more...]
Chocolate Cherry Smoothie Recipe
Three Detox Green Juice Recipes
The last couple of weeks have been filled with longer days, a little bit more work, and a whole lot less sleep. So, a couple of days ago, I finally got my act together and went to see my chiropractor. I don't know what I waited for, but I slept better than a baby that night. Yet, I could feel better. So, yesterday, keeping up with the self-care momentum, I treated … [Read more...]
Peachy Plum Green Smoothie Recipe
Less than 48 hours in the new home and I am already joyful, albeit tired. To be honest, I am exhausted!!! We have been moving, unpacking, and I have been cleaning like a mad woman. Who knew there would be so much to do when I thought we had so little. We spent the last few years in spaces half of the house we bought. So, I need energy...super energy! There is just so … [Read more...]
Is it Healthy to Drink Green Smoothies?
I recently received an email from a Vegalicious reader. She wrote: Elena, I am just now beginning my transition to a plant based diet. I have never liked greens, or many vegetables for that matter, but heard that they are great for my health. I am looking for ways to incorporate more of them into my diet. I began to make green smoothies to help me. At first I could … [Read more...]
Maca Peanut Butter Shake Recipe
I know that it is the middle of the summer, yet, I found my maca recipe inspiration in something that belongs more in the fall season. It was accidental actually. I was looking for new ways to enjoy maca and pondering on what recipe I could create to make it more palatable*, while my family was grocery shopping. Hubby, who eats almost perfectly, still enjoys occasional … [Read more...]
Watermelon Rind Smoothie Recipe
"Waste not, want not," goes the saying. In nutrition, there are times when food scarps have more, or as much, nutrition, as the parts we love to enjoy. Throwing them away would not only be wasteful, but would mean that you would miss out on loads of health promoting nutrients, minerals and vitamins. Today I will tell you about one such jewel, which, instead of making … [Read more...]
Imperial Superpower Cappuccino Recipe
Have you ever wondered what would happen if you combined a few superpower foods together? Maybe you haven't, but I could not help but wonder what would happen if I did just that. So, I whipped up one of the most energy loaded drinks--a superfood cappuccino. When I am created this drink and I loved its taste creaminess, I gave it to Hubby to taste. "How is it?" I asked … [Read more...]
3 Day Detox | Day 3
The finale! Last day of the 3 Day Detox! I cannot believe how quickly the other two have gone. If you missed the first two days and are just now catching up, make sure to check out these posts: 3 Day Detox | Day 1 3 Day Detox | Day 2 Yesterday I indulged in a couple of different green smoothie recipes. I added carrots to one and beets to another. One was made … [Read more...]
3 Day Detox | Day 2
You knew I was going to ask you this, so here it goes... :) How was your Day 1 of the 3 Day Detox? I want to hear (read) it all--good, bad and ugly, so, let me have it. Tell me all about it in the comment section under this post. I can tell you that I am feeling great. I have had: green smoothies, green salads with some chickpeas and barley in them, which tasted … [Read more...]
3 Day Detox | Day 1
Happy Monday! Let the cleanse* begin! I am so excited and looking forward to the results of this 3 day detox. I know that my body is excited as well, as I am now sipping on my delightful, berry and chard filled green smoothie. I am planning to continue my day with a ton of raw veggies, smoothies, and raw soup, with an addition of some beans and cooked barley, if I am … [Read more...]


text:
Undergraduate students at Lawrence Technological University are encouraged to participate in undergraduate research. To facilitate this LTU will fund ten $1000.00 undergraduate research projects.
Funded projects will be sponsored by a faculty mentor and include either basic research that produces new knowledge based on the student's ability to analyze, synthesize, select a hypothesis and test its validity, or applied research that leads to an alternative solution to a problem based on the student's ability to analyze, synthesize, design, and produce or simulate a product or model. Both basic and applied research projects will engage in a literature search, select appropriate research methods, draw a conclusion concerning the value of their work, provide evidence supporting that conclusion, and display or disseminate the work for public review.
Student proposals should be emailed to Assistant Provost Jim Jolly, email@example.com no later than November 21, 2017. Funded projects will be announced by December 1, 2017. Funding will be made available upon announcement and will remain available for one year or until degree completion whichever comes first.
**Senior Projects are not eligible for the Presidential Undergraduate Research Award.
Proposals Deadlines:
November 21, 2017 for Fall 2017 semester
April 1, 2018 for Spring 2018 semester
Click here for research requirements and application details.


text:
City earn Hammers replay
West Ham and Manchester City will have to do it all again after a goalless draw in their third round FA Cup clash.
Last Updated: 05/01/08 6:16pm
West Ham and Manchester City will have to do it all again after a goalless draw in their third round FA Cup clash.
Defences were on top at Upton Park as both sides cancelled each other out.
Manchester City enjoyed the best of the first half with Robert Green denying Stephen Ireland and Anton Ferdinand blocking debutant Nery Castillo's close-range effort.
Chances were few and far between in the second half meaning the two sides will meet in a replay at Eastlands to decide who will go through to the fourth round.
Both sides concentrated their attacks down the respective left flanks, with Matthew Etherington and Martin Petrov heavily involved in an open first period.
John Pantsil slipped the ball to Etherington who burst down the left flank and looked to pick out Hayden Mullins in the box, forcing Micah Richards into a last-ditch clearance.
Carlton Cole's flick fell to Etherington on the edge of the City area but his left-footed volley was shanked wide.
With all the attacking, open football on offer a goal seemed inevitable and City increasingly appeared likely to make the breakthrough.
Mark Noble conceded possession carelessly in the West Ham half and Vedran Corluka chipped the ball towards midfielder Ireland in the box.
Ireland opted to take his shot first time on the turn and could only hook his volley over the bar.
Petrov steamed past Lucas Neill into the box and went down under a challenge from Ferdinand but referee Rob Styles waved away strong appeals for a penalty.
City were then denied by a point-blank save from Green from Ireland, who latched onto Petrov's deep cross with a driven volley, which the Hammers goalkeeper touched over the bar.
West Ham were creating opportunities themselves, with Joe Hart called on to produce an excellent near-post save from Etherington's low drive.
Meanwhile, Petrov continued to be a constant threat down the left and he whipped another dangerous low ball towards Castillo.
If Ferdinand had been lucky to escape censure for his early challenge on Petrov, he earned that good fortune with a magnificent last-ditch interception to deny the Mexican just six yards out.
West Ham began the second half on the counter-attack again, earning another free-kick within striking distance but Ashton's drive was blocked easily by the City wall.
Green was alert to race off his line and dive at Corluka's feet as the Croatian burst into the box.
And the West Ham goalkeeper was forced to produce another athletic block to deny a fierce Ireland volley for the second time.
Cole saw a volley disappear wide and when the ball fell to Spector in the box from a corner his first-time shot was lifted over the bar.
Ashton got the ball caught under his feet inside the City area but then latched onto a cross from Kyel Reid and forced Hart to tip his header over the bar.
Dunne scrambled back to get ahead of Ashton and clear Reid's cross for an injury-time corner which West Ham could not capitalise from.
Cole challenged for the ball and West Ham appealed for handball and a penalty but there was no dramatic finish.
|Team Name
|West Ham United
|Manchester City
|Shots On Target
|Shots Off Target
|Blocked Shots
|Fouls Conceded
|Yellow Cards
|Red Cards


text:
Since I've started posting fashion videos on my LetzMakeup channel, various online clothing companies have been contacting me about their products and joining their blogging programmes (More so than before). I always politely declined any of these offers before I was filming styling & fashion videos, but now that I am & it's relavent to my channel, I am happily considering a few of the offers. I jumped at the chance to join the Romwe.com blogger programme as I've spent the past year drooling over the bits I've seen many of my youtube subscriptions and favourite fashion blogs showing off, from the China-based online brand. And since my first order, which was partly subsidised, I've not been disappointed. Now because of my happy experience with Romwe I'm definitely interested in a few of the other companies who have approached me.
(And let me say here for the record, as with my makeup work, I will always be honest about my experiences with companies and be transparent about collaborating)
Anyhow, with that out of the way, time to get to the point of this blog post.
I noticed that a many of these China based companies carry many of the same items but with varying pricing.
One such company which has approached me about their blogger programme is SammyDress.com. As with all companies that contact me, I did my research after reading their proposal to get a feel for them & their products and see if it's something that would benefit my blog and my readers/viewers.
The first thing that struck me was just how inexpensive their products are. Way more affordable than all their counter-parts, and I checked!! The second, after continuing my research, was the mixed reviews on the company (As well as many complaints). Their products don't seem to be the main issue (paying $5 - $10 for an item of clothing shouldn't have you expecting top-quality merchandise) however many people have hit various forums to complain about various issues they have had with the brand, such as very long waiting periods for processing or delivery, or products not being delivered in the order with the rest of their stuff, or suddenly being out of stock without prior warning etc. After nosing about the internet a bit more, I've come to the conclusion that sammydress.com is not a 'dodgy' or dishonest company, but rather a company that has trouble keeping up with the volume of orders they receive, or keeping track of all their orders and subsequent correspondence.
The reason for my babbling.... I'm still totally gobsmacked by the low prices of their products and wanted to decide about the company for myself, and from my own experience (as a regular buyer).
So I decided to purchase from them myself before placing any orders through the blogger programme so I could see how it goes, and also so I can compare the two experiences. This isn't me trying to 'catch out' Sammydress, just pure curiosity as I don't like having my opinion made up for me by other people and through other peoples experiences!
I decided on this absolutely gorgeous dress below which comes in 'one size' but seems to still be quite small (thanks to the Chinese sizing) and is supposed to fit my size 6/8 frame.
It cost me a mere $15 (US dollars) and the shipping, which is calculated by weight, only $5. This when changed over to €s comes to only about €15!!
Beware though that the heavier the products, the greater the shipping fee and I have no idea yet as to whether I'll get charged by Irish customs when the package arrives. I didn't get charged for my Romwe order, where I chose the free (and slower shipping) method which arrives via HongKong post. I chose the standard shipping with Sammydress which also comes via HongKong post (and can take a month or more at 'up to 25 BUSINESS days to arrive) so I would be surprised if I got charged. I would expect it if I chose the quicker delivery methods using delivery companies.
I found the exact same dress on the Sheinside.com website for a comparatively whopping $45.00 ON SALE down from $53.97.... BUT Sheinside.com does allow you the option of a free shipping method. Plus sheinside.com, like the similar Romwe web-store, has a much better online reputation.
Either way I'm happy to take my chances on the lesser priced option from Sammydress and see for myself how I get on!
I think as long as you know what to expect when shopping from these cheaper websites, you do so "at your own risk" so to say. I'll always give something a first go, and if it doesn't work out, I know to stay clear a second & third time.
For now, I'm looking forward to receiving my dress, even if I am in for a bit of a wait. And I will update ye all on my experience & the actual item once it arrives!!
I'm also interested in hearing (reading) any of yeer experiences with any of these companies.
Thanks for making it through my rambling ^_^
Catch ye later,


text:
I hold to my earlier positions even more strongly now. Democracy works best when the right people vote for the right candidate. There's nothing virtuous about uninformed people voting for whichever candidate strikes their fancy.
If you don't know how many senators we have per state, please, do us a favor and stay home this election year.