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About Altitude Restaurant - Hyatt Regency Denver
Altitude, named for Denver's "Mile High" elevation, serves contemporary American cuisine in comfortable elegance. Enjoy a great atmosphere while savoring the flavorful creations of our talented chefs and the attentive service from our friendly staff. For a more creative view, adjust your sights to our décor. Our walls are scattered with innovative pieces created by local artists. The cool, inviting decor features a showcase kitchen and comfortable high-backed booths which create a space ideal for gathering your thoughts as you start your day, conducting business over a meal or having a leisurely dinner. Serving breakfast, lunch and dinner, Altitude offers both local favorites and its own unique creations.
Denver, CO 80202
Dining Style:
Casual Dining
Contemporary American, American
Hours of Operation:
Breakfast: Monday - Sunday: 6:00am; Lunch: Monday - Friday: 11:00am - 3:00pm, Sunday: 12:00pm - 3:00pm; Dinner: Monday - Sunday: 5:30pm - 10:00pm. Breakfast Buffet: Monday- Friday 6:30am- 10am Saturday - Sunday 6:30-11am Lunch Buffet: Monday- Friday 11am-230pm Sunday and Saturday 12pm-230pm. Dinner Prime Rib Buffet $29.50: Friday and Saturday 530pm-930pm
Cross Street:
California & 15th Street
Dress Code:
Casual Dress
Price Range:
$31 to $50
Payment Options
AMEX, Diners Club, Discover, MasterCard, Visa
Phone Number:
(303) 486-4434
Parking Details:
For the convenience of our guests, we offer $10 off Valet and Self-Parking.
Public Transit:
Light Rail Service/RTD – Stops 1 block from the hotel at the Convention Center/Performing Arts giving you access to all the Mile High City has to offer.
Beer, Full Bar, Non-Smoking, Outdoor dining, Takeout, View, Weekend Brunch, Wheelchair Access, Wine
Altitude Restaurant - Hyatt Regency Denver Ratings and Reviews
Vegetable curry was soooo good!! Our server, Barbie, was great and did not skip a beat. She was friendly, professional and joked around with my partner and I. The restaurant and the service was outstanding and is the reason we choose Hyatt again and again. Please recognize Barbie for the amazing work she does. Thank you.
I was disappointed as I thought I was making reservations for The Peak. I didn't know The Peak was the bar upstairs. Altitude is a misleading name. The restaurant was empty which speaks volumes. The Peak was packed (we had a drink after dinner to see the view). The restaurant needs to be The Peak (with a better name).
Breakfast meeting, chose to order off menu and stay at table talking. Pet peeve when ordering breakfast out - have everything arrive at once. My omelet came out lukewarm, but the bread for the table (toast, English muffins) came out only after well into my breakfast (and not really hot). While I might eat here again due to proximity to Colorado Convention Center, I can't strongly endorse for breakfast.
We had reservations but showed up early and they were able to seat us right away. Our waitress Kimberly was very perceptive and took it upon herself to see if different arrangements could be made to accommodate our tastes. The manager came by to make sure everything was going good for us. It was very comfortable and we felt very attended to. Thanks Kimberly and the staff at Altitude.
Four of us dined here before our show at the Bellco. The trout dinner was wonderful and the prime rib was as well. Good prices and nice location for Performing Arts events. Parking was kind of hard and expensive, next time taxi or Lyft!
We also went up to the 27th floor for after dinner drinks and dessert, what a beautiful view!
We came here for the Prime Rib Friday Night special. It took 50 minutes to get our salads, and did not get bread (when everyone else did), kids did not get kids' meals until nearly 9PM when I requested that they speed them up! Service was terrible. Food was great, but should not have taken that long when they weren't busy and it was a special that would have been cooked hours in advance!!
We enjoyed a Mother's Day brunch at Altitude and what fun it was! Kids 5 and under were free and there was not one time we felt that our young ones were out of place! They had as much fun as us adults did. First of all the customer service is outstanding. We never had to ask for anything. Drinks were refilled continuously. One of the kids dropped a spoon and someone was right there to pick it up and provide a new one. Plates were cleaned off regularly to provide us room. The food choices were great. This buffet had 3 different choices of meats in the carving station alone: Prime rib, pork loin with a cherry sauce, and crab stuffed salmon. There is an omelet station where you can get all the fixings or just a fried or scrambled eggs if you wish. There is a pancake station with not only the usual toppings but a fresh berry topping with huge berries in it. Then there is a whole other room with an assortment of breads, cheeses, sliced meats and nuts, as well as a fully stocked salad bar and about 10 options of warmed foods. The roasted vegies were a favorite of mine with huge pieces of tender vegetables, not your run of the mill sliced zucchini and yellow squash. Finally there was a 3rd area of deserts that made my day so complete! These were not your usual deserts but red velvet cake with some kind of frosting in between that was fantastic. On top of the slice we had was a beautiful butterfly made out of white chocolate. Another option was cupcakes that looked as though they came out of "Cupcake Wars" with chocolate lady bugs or tiny chocolate straws as part of the decorations. There was lemon poppy seed berry cheese cake slices and bonbons to select from and so many others I cannot even begin to remember their names. I am not giving the food a 5 star rating as a couple of items were overcooked/dry which was probably due to the fact that we had a late lunch setting. In spite of this I would definitely recommend this brunch and we will return.
We held several business breakfasts and Lunches over a three day period in conjunctions with a Conference being held in the Convention Center Across the Street. The entire staff was so very accommodating and welcoming. As a Meeting Planner I highly recommend!
Again sincere thanks to all!
Lovely Hostesses greet you as you walk. Wait staff very professional. My first meal there I didn't eat the sandwich because I felt it was just bland. When the waiter say I didn't eat much he asked why, and the next thing I know the Chef himself came out to apologize! Of course they offered me anything I wanted at no charge - very professional!
We had several Business Breakfast/Lunches and all went wonderfully.
Sincere thanks to both Jordy and Demi the hostesses and their entire waitstaff!
We were only ones in restaurant at first. Seated immediately, excellent service from all staff, salmon was perfectly cooked and incredibly tasty, chicken was very flavorful with Brussels sprout hash, also quite good; vegetable curry was ok, not awesome but not bad. Wine list was good.
Very nice brunch and great atmosphere. I however, was very turned off when I received a call from the restaurant two days before our reservation and a message said if I did not call back to confirm my reservation that day by 5pm they would cancel our reservation. I thought this very odd and have never experienced this with a restaurant.
Very disappointing. Hour and half to get food. Waited 10 minutes for appetizer plates after appetizers arrived. 20 minutes to get all good served. Last food to come out obviously had been forgotten and was rare salmon. Over 2 hours and 15 minutes for meal. Wanted desert but didn't want I wait for it to arrive. Embarrassing event for me and my customer.
This was my first time at Altitude. Wow, was I impressed. From the first course to the last, everything was delicious. Caesar salad was the best I've ever had. Prime rib was cooked to perfection. Asparagus was wonderfully seasoned. The chocolate cake with coconut filling and icing was the perfect ending.
Being at the HYATT we thought it would be overpriced. We were with our melaleuca group But the daily pasta feature was Beef Stroganoff -- oh my -- it was amazing -- the beef was tender -- it was very very tasty.
my husband had the Bison burger -- it was done to perfection.
the waiter was also very attentive and made him a special drink. but now birthday song lol -- please thank our waiter and your chef xoxo........
But the Blue Pear salad was one of the best I have every had
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Mary kate olsen dating history
31-Mar-2015 11:07
The twin has kept a surprisingly clean record, but then again, who has time to date when you're running a multi-billion dollar empire?
Wonder if somewhere amongst all those teen videos is a decidedly adult celeb sex tape?
Mary-Kate dated shipping heir Stavros Niarchos for five months in 2005, in the spring and summer leading up to her sophomore year at NYU.
That fall would live in infamy as that time Paris Hilton stole MK's boyfriend.
She Initially Said No When He Proposed Despite Sarkozy wanting to propose back in 2013, a source told Us in April 2013 that the former Full House star said no when he first brought it up."She's making him wait," the source revealed. She wanted to make sure he would be good to her."Another insider noted that the once-wed multimillionaire "wants to lock her down for life."Her Engagement Ring Cost More Than ,000In February 2014, Sarkozy popped the question with a 4-carat vintage Cartier diamond ring that he reportedly purchased for ,250 at a Sotheby's auction. "Mary-Kate is funny and sweet."And there's no bad blood between Olsen and Sarkozy's ex-wife, Charlotte — who split from the French financier in 2010 after 13 years of marriage and share two children, Julien, 13, and Margo, 11."MK asks her permission about things that concern the kids," one insider told Us at the time. "I find it's better to focus on what's in front of you and to keep putting one foot in front of the other."And from the beginning, her family loved him."Mary-Kate's family thinks Olivier is the best thing to happen to her," an insider told Us in February 2014 after the pair got engaged.
Mary-Kate Olsen was spotted sporting a gold ring on her left ring finger Sunday, and rumors have been swirling about the accessory's implications for the designer, 26, and boyfriend Olivier Sarkozy, 43.
And yes — we're totally going beyond the undying memory of Justin Bieber.

subset: commoncrawl


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Primark Haul21:33
Yes I've been to Primark and I got some goodies. I don't tend to by a lot in one go so I thought what better way to share it than by vlogging.
So Check Out my Haul.
I hope you enjoy it and I'd love any feedback.
Charlotte - I'm passionate about Fashion, Food, Travel and Life. This blog is a place where I want to share all the things I love with you.


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GraphicRiver Corporate Business Flyer 7146028
Photoshop \ Print Template \ Flyers \ Corporate
Business \ Included \ Myriad \ Download \ Version \ Photoshop \ Photodune \ Please
Print Template - Corporate Business Flyer 7146028 by Mr-Graphics @ GraphicRiver
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Corporate Business Card; Corporate Business Card; Smart Phone Style Business Card; Smart Phone Style Business Card; Corporate Business Flyer Template ; Desk Calender 2015; Corporate Flyer Template .
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tap to bring up your browser menu and select 'Add to homescreen' to pin the The News web appGot it!
tap to bring up your browser menu and select 'Add to homescreen' to pin the The News web appGot it!
The government schoolteachers who had been staging a demonstration against the Punjab government from Saturday afternoon ended their protest on Sunday evening following assurances from the Punjab School Education minister.
The teachers had been observing a sit-in on The Mall near the Punjab Assembly demanding the government to stop privatising the public schools in the name of quality education.
Punjab Teachers Union (PTU) had given the call for the demo in which a large number of teachers both male and female participated for two days to record their concerns over handing over of schools to private sector and NGOs and problems being faced by them because of the Schools Department's policies including delay in upgrading of teachers.
Punjab School Education Minister Rana Mashhood talking to The News said he had personally talked to teachers and assured that their jobs would be secured in the process of involving private sector to improve public schools following which they called off their demo. He said the government was aware of teachers' genuine concerns and was always ready to address the same. He categorically said the government had no plan to offer golden handshake to teachers of the schools being handed over under the Public Schools Support Programme (PSSP). "The teachers of such schools will not lose their jobs", he added.
PTU President Sajjad Akbar Kazmi said the minister had called him on phone following which a meeting of PTU office-bearers and Schools Department's representatives was held. He said most of the demands had been accepted therefore the PTU ended its protest.
PML-Q: Pakistan Muslim League-Quaid (PML-Q) leaders have said their party supports the protesting teachers and said alleged that due to defective educational policies of Shahbaz Sharif, teachers and poor students are suffering from mental torture. The government is closing running schools whereas Ch Pervaiz Elahi had reopened closed schools in his government in Punjab, established new schools, upgraded educational institutions and provided maximum possible facilities and incentives to the teachers and students.
These views were expressed by a PML-Q delegation headed by Lahore PML-Q Organiser and former MNA Mian Muhammad Munir and Women Wing organiser and former MPA Amna Ulfat while showing solidarity with the teachers. Mian Munir and Amna Ulfat said teachers protest against the system of distribution of schools among the favoured ones. They alleged that Shahbaz Sharif has closed down thousands of schools. He should instead of snatching away schools from children provide maximum better facilities to the poor students.


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Edward Lanigan Ireland to Ontario Canada
Seeking information on Parents and possible other siblings of Edward Lanigan.
b. May 12, 1841 Ulster, Antrim Ireland
d. 1926 Atherley, Ontario, Canada
Edward attended the Seminary in Maymouth Ireland for one year.About 1859 he went to Austrailia to work the goldrush.Edward returned to Ireland around 1863 and worked as a blacksmith.
Spouse #1 Bridget McCowan (unconfirmed)
Spouse #2 Catherine Fisher b. c 1852 a native
of Castletown, County of Donegal
Edward married Catherine Fisher and resided at Fyfennan House Killybegs, County of Donegal.They came to Canada in 1878 and settled in Egansville and then Orillia and finally Atherley, Ontario, Canada. They had 7 children, 5 of which were born in Ireland.
It is believed Edward's father died c. 1844 and his mother's last name may have been Butler.Edward was the youngest in the family.
Confirmed Siblings:
1) Michael Lanigan: settled in Rochester, NewYork, married with 2 daughters
2) John Lanigan: settled in Washington D.C.; not married, died 1881


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Results 1 to 4 of 4
Thread: Text box moving.
06-25-04, 16:13 #1Registered User
- Join Date
- May 2004
- Posts
- 90
Unanswered: Text box moving.
I was wondering if there is any way to move a text box from one part of a report to another depending on a variable.
Example. I am priting certificates and depending on what the certificate is for then there may be more of less text at the bottom of the certificate.
It looks weird on the certificates that don't have much text because there is a lot of blank space at the bottom. I have broken the text down into two boxes and that helps but it is not ideal. I was just wondering if there was a property you could set to say where the text box is.
ex. Me.textBox.Top = 5
or something. (The above does not work btw).
06-25-04, 16:17 #2Registered User
- Join Date
- Apr 2004
- Location
- metro Detroit
- Posts
- 634
I don't know about moving the text box, but you can create 2 text boxes and set the visible property on and off as appropriate.
06-28-04, 03:12 #3Registered User
Provided Answers: 1
- Join Date
- Oct 2003
- Location
- Ger
- Posts
- 1,969
The idea of Rouge is good, also you can use something like that, in the open form event, to move the text box
Me.ContactID.Top = Me.ContactID.Top + 50
but you should have enough space in your detail scope to be able to move your text box.
Try to use Rouge suggestion it is better than moving objects
06-28-04, 09:59 #4Registered User
- Join Date
- Jun 2004
- Location
- Terrapin Nation
- Posts
- 205
"Me.textBox.Top = 5"
Actually that would does work. You need to multiply it by 'twips' to get the desired effects though. 1440 twips = 1 inch so if you wanted to move an object 5 inches you would do something like:
Me.MyTextBox.Top = 5 * 1440


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Arthritis is one of the most common chronic illnesses affecting children, yet it often goes undetected or misdiagnosed when symptoms first appear.
This July, Juvenile Arthritis Awareness Month, the Arthritis Foundation is focusing on increasing awareness of early signs and symptoms of juvenile arthritis and resources available for families affected by the disease.
In a continued effort to reduce the heavy burden of juvenile arthritis, disability and cost of this chronic disease, the Arthritis Foundation is leading the way to conquer this disease through increasing:
Awareness and Support:
Juvenile Arthritis Conference – Taking place July 18-20 at th Hyatt Regency Orange County hotel in Anaheim, California, the nationwide conference is held annually for families affected by juvenile arthritis and other rheumatic diseases.
Specific educational tracks focus on issues relating to parents teens/young adults, children affected by arthritis and their siblings. In addition, the conference offers families a chance to network with each other and learn new techniques for managing juvenile arthritis and other rheumatic diseases.
Eleven states do not have a single specialist to treat children with juvenile arthritis. Arthritis advocates speak out for federal support to train more pediatric rheumatologists and for more research funding to help children with all forms of juvenile arthritis.
Advancing the Quality of Life for Children with Arthritis — For more than 60 years, the Arthritis Foundation has been a leader in advancing treatments and a cure for juvenile arthritis.
Currently, the Arthritis Foundation funds researchers working in the field of juvenile arthritis, totaling a commitment of more than $1.1 million in 2013.
These researchers are investigating a wide range of topics, from how environmental and genomic factors might play a role in triggering juvenile arthritis, to collecting data and evaluating the efficacy of standardized treatment plans, to the development and testing of a smart phone app to help children cope with pain.
The Arthritis Foundation also is proud to provide $2.4 million in grant money to date to support the Childhood Arthritis & Rheumatology Research Alliance (CARRA), a national organization of pediatric rheumatologists who have joined together to answer critical research questions.
Juvenile Arthritis Registry — Efforts to track drug side effects and establish treatment benchmarks through a registry aim to benefit future juvenile arthritis treatments.
More information on juvenile arthritis and resources for families is available on the Arthritis Foundation.
Source: Arthritis Foundation


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New 2017 Buick Encore Preferred II FWD
Preferred Price $26,351
Talk about a deal! Here it is! Shelton Buick GMC Advantage: Every vehicle comes with Shelton Buick GMC Advantage; which means we will pay up to a $500 deductible in collision comprehensive claims for all potential body shop work. How would your family like to hear that you are driving home in this gorgeous 2017 Buick Encore? Where are you going to come across a nicer Encore at this price? Nowhere, because we've already looked to make sure! Shelton Buick GMC has been serving the greater Rochester, Rochester Hill, community for the last 55 years; we offer a large selection of new and pre-owned inventory, a pressure-free environment, and a friendly experienced sales staff that would be proud to help you with your next vehicle purchase. We also have extensive finance options available. Please call or Email us to schedule a test drive, or stop by our store today!


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We may have shut our doors, but as a final farewell we've announced more than £100,000-worth of IdeasTap-funded opportunities on Hiive.
Find out how you can apply...
Three hundred and seventy-one applications, 20 prizes of £500, seven IdeasTap members as judges, and just 19 lucky projects: no one said the Top Up Fund would be easy. Find out below who will be getting that all-important cash injection for their place-orientated creative project…
Variable 4 by James Bulley is a site-specific outdoor 24-hour sound installation that composes music in real-time based on the current weather conditions.
Lewis Chaplin's project The Tristans will involve sending a large shipment of disposable cameras to the remote island of Tristan Da Cunha, allowing the residents to portray themselves through photos.
Life in a Northern Town by Abigail Tarttelin is a documentary short about the effect of the fragile economy on the north-eastern town of Redcar, where the plant – which once once employed most of its population – has been mothballed.
Louisa Pestell's Choreographing Community will involve eight weekly dance workshops celebrating Bermondsey and its cultural, creative scene.
Lost & Found by ReCon is a festival that allows audiences around Manchester to stumble across art in everyday situations, culminating in a final day of performances in the Contact building.
Wignall & Moore presents The King & The Minotaur: a unique collection of art and performance hidden away amongst the corridors and chambers of an 1850s barn in King's Cross, London, from 8 to 30 April.
The Pod Project by Illographics aims to inject positivity and creativity into a deprived area of Birmingham through a community space, where groups learn and share skills and ideas.
Nathan Jones' Poem in Flux will be an original sonnet about Liverpool, using up-to-date data on the city – including population, temperature, criminal convictions, and traffic data – so each line will change at a different rate.
Bread and Goose's project Fox in the Snow is a tale of young love and bicycles, inspired by a Victorian market arcade in Brixton.
Dougie Evans' Frozen Erosions, inspired by the landscape of Devil's Dyke in Brighton, is a collection of improvised music using field recordings and contact microphones.
Sondry Folk's A Canterbury Trail is an inclusive arts trail around Canterbury involving performance, theatre, aerial circus, painting, sculpture, video and sound installation.
Crow Theatre and the Community are creating a piece of theatre about the local community in and around Wandsworth, culminating in a performance at the newly-established Arts Festival in May.
Angry Young Men's Lost in Mozart is an urban musical driven by grime rap lyrics and classical music, set on two real-life north London estates.
Dylan Spencer Davidson's project Nova Cantabrigiensis is a book about outsider artist John Devlin, who produced over 360 beautiful and moving fantasy illustrations during a period of manic depression.
London's Centenarians is a photography project featuring portraits of 10 Londoners on their 100th birthday.
Jo Gleave's project is a site-specific promenade performance taking place in the now-disused Newman Brothers Coffin Fittings Factory.
5x5x5 by Tom Duncan will produce a series of five locally-themed music videos in Moray, Scotland, culminating in a showcase screening and live performance.
Jake Conrad's project is a very creative free guide to the very creative Ouseburn Valley; what Jake calls "a cultural oasis".
The Knowledge Shop by Alex Parry will document, through street drawing, one of the largest festivals of gypsies in Saintes-Maries-de-la-Mer, France and the Appleby Horse Fair in Cumbria. The drawings will then be shown at Amnesty International's headquarters as part of Gypsy Roma Traveller History Month.
If you're looking for a cash injection for your creative project, apply for the IdeasFund Innovators.
To find out more about the winning projects, visit the winners page on the closed brief.
Image courtesy of UncoveringWestport on Flickr.
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The end of an era
Who we support and why
Five common CV mistakes
Five common cover letter mistakes


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Hotels in Punta Braccetto, Italy
Search & Compare Punta Braccetto Hotels
Collect 10 nights, get 1 free night
And look out for Secret Prices on select hotels
Best hotels in Punta Braccetto
Hector overviewHector is known for its wineries. Visitors can plan a fun excursion to Tickle Hill Winery and Penguin Bay Winery. There's plenty to explore, including local sights like Sheldrake Point Seneca Lake Tasting Room and Hazlitt 1852 Vineyards. Hector is an inviting destination that has something for everyone.
Where to stay in HectorWhether you're planning to stay for a night or for the week, the area around Hector has accommodations to fit every need. Search for hotels in Hector with Hotels.com by checking our online map. Our maps display the areas and neighborhoods around all Hector hotels so you can see how close you are from landmarks and attractions, and then refine your search within the larger area. The best Hector hotel deals are here with our lowest price guarantee.
How to get to HectorFly in to Ithaca, NY (ITH-Tompkins Regional), 20 mi (32.2 km) from downtown Hector. Elmira, NY (ELM-Elmira - Corning Regional) is the next closest major airport, 24.9 mi (40 km) away.
What to see around HectorFun outdoor activities are on hand along with these attractions:
- • Tickle Hill Winery
- • Penguin Bay Winery
- • Sheldrake Point Seneca Lake Tasting Room
- • Hazlitt 1852 Vineyards
- • Red Newt Cellars Winery
- • Leidenfrost Vineyards
- • Hector Wine Company
- • Standing Stone Vineyards
- • Bagley's Poplar Ridge Vineyards
- • Bloomer Creek Vineyard
When to visit HectorWondering what time of year to travel, or what clothes to pack? Here are seasonal norms to help you with your planning:
Seasonal temperature averages
- January-March: 49°F day, 17°F night
- April-June: 80°F day, 31°F night
- July-September: 82°F day, 47°F night
- October-December: 66°F day, 19°F night
- January-March: 5.63 inches
- April-June: 8.94 inches
- July-September: 10.75 inches
- October-December: 7.05 inches


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Hard Rock Mumbai "Elephant" Bottle Opener Magnet
Sold for:
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- Sold Date:
- Source: eBay
Hard Rock Cafe Mumbai "Elephant" Magnet Bottle Opener. Very Cool Item. Rare hard to find. Payment & Shipping I accept, personal checks, MO, Cashiers checks, Bid Buyer to pay $3.75 Shipping & Handling in USA $1.75 each additional item. International $5.00. and $2.00 each for additional Items will be shipped in bubbler mailer. I will hold checks until check clear. Insurance is $1.35 for the first $50.00. Extra also offered, Registered Insured Airmail up to $100.00 for $7.75 International orders. Seller cannot be responsible for lost or damaged items if not insured. Buyer must contact seller within 5 days. Please do not bid if you not intend to pay!! Good Luck & Happy Bidding


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Main Teri Tu Mera Punjabi Movie Story |Synopsis | Plot – Roshan Prince
Main Teri Tu Mera is the story of a young boy from a village. He is very popular in village just for silly reasons. He stay in the world of fantasy. Amru is the name of this common village boy who is a full time day dreamer.
Amru just dream about how his love life should be and about his perfect life partner. One day he was dreaming and he meet a modern city girl who fall in love with him. She always try to make him happy and spend good time with him. There is a happy ending to the story when they get married.
After this every there is a u-turn in the story of Amru when he got to know about the same girl. The dream becomes reality, and Amru get confused and did not believe it. There is more confusion in the story when the girl simran claims that she is married with Amru.
How things change further? How could she claim about marriage with Amru.
Characters in the film
Roshan Prince: Amru
Jazz Sodhi: Simran


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Those who have been injured through the fault of another are entitled to claim compensation. This can be done with the help of a lawyer – and traditionally this would almost certainly be how it would be done. For better or worse, however, the role of professional lawyers in personal injury compensation claims is changing. While there is no doubt they still have a place, the nature of that place has undergone a shift.
Grabbing headlines last month were a whole raft of proposed reforms, currently still under discussion, to the way whiplash claims are handled after a traffic accident. Among other changes, these reforms could see it become possible – even compulsory – for personal injury claims worth up to £5000 to be handled through the Small Claims Court. Barring further disputes and complications, this is a track that does not involve professional legal representation.
The result of this would be essentially the removal of lawyers from lower-value compensation claims and, while the main focus of the proposals is whiplash claims, this would not be limited to the arena of traffic claims. This particular proposal refers to all personal injury claims worth up to £5,000, and as such lawyers would be also be effectively removed in the same way from a workplace injury compensation claim, a medical negligence claim, or indeed any other personal injury case, so long as the value of the claim is £5,000 or less.
This prospect has been greeted with at best mixed reception; some lawyers feel that a route to allow lower-value claims to be handled without their involvement represents the lifting of a burden. Many others, however, fear that the lack of professional legal assistance in these cases will hinder justice, and could lead to more frivolous claims being brought into action without lawyers to nip them in the bud.
Another thing changing the role that lawyers play in injury compensation claims is a new initiative from the NHS which could potentially see medical negligence claims handled through mediation. The new mediation scheme from the NHS Litigation Authority launched this month, and was originally piloted in 2014.
One of the things that is interesting about this scheme is the fact that mediation is a concept that is broadly supported by lawyers for the resolution of many disputes. It is generally faster, cheaper, and more amicable than the courts for all involved. However, a medical negligence claim is quite a different matter from most disputes that would be handled through mediation, and some are uncertain as to whether it is suitable. Yet it is important to note that this scheme does not necessarily exclude lawyers; claimants are entitled to have a lawyer present to advise and represent them if they wish. For cases where the financial settlement is a priority, for example where patients have been left out-of-pocket or facing additional financial needs, this may well be the preferred option.


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01 January 2005
If you can make it past the first 5 minutes of each scene without blowing your load, consider yourself lucky. After all, these babes are grade A certified premature ejaculation material at it's finest. First they tempt you with their firm tits and perfect bodies, then they satisfy you and slide into the sack for some filthy fucking and sucking. These pole-sliding sluts have all the right moves & they're here to tease and please all you perverts!
Watch the official Strip Tease Then Fuck 7 2005 trailer in HD below.


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- Please select a date to see the proper prices!
- Meal can be requested on the spot
Best offer
55 € / person / night, no meal
Description of the Accommodation
Rooms, services City-Hotel-Garni-Diez is offering ten tasfefully furnished, nice rooms for those looking for a place to stay at in Diez. The hotel is offering you freshly prepared fine local meals in its restaurant every day. Parking possibility is available nearby for guests arriving by car. Bike rental, billiard, diving and boat rental opportunities will also be available nearby to help you spend your leisure time actively. The café and the bar have excellent atmosphere for a relaxed evening talk or a personal meeting. In the safe your valuables can be the safely secured. In case you'd bring your laptop along, you may go online via wireless Internet connection (WiFi) available at the hotel. An exact and detailed list of equipment in the rooms and of the services provided by City-Hotel-Garni-Diez you will find on the information sheet below, including any applicable additional fees.
Payment Advance bank card payment or credit card guarantee may be required for the reservation, depending on the chosen date, room and price.
Arrival, opening hours The earliest time to check in to your room is 14:00, the latest time to check out of your room is 11:00. English and German languages are spoken by the personnel.
City-Hotel-Garni-Diez rooms Rooms
- Please select a date to see the proper prices!
Accommodation services
Free WiFi in shared places
Relaxation: Billiard, Bike rental at the accommodation
Scuba diving nearby, Boat rental nearby
Pet friendly (10 €/night), Garden, Bar, Cafe, Safe deposit box
Own restaurant


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Friday, July 10, 2015
Gym Owners: Why you should not require shirts in your facility
4 comments:
Hey there, so glad to see your blog is still alive! I'm a blogger too, & in similar sphere, actually: Hot guys pictures.ReplyDelete
I adore shirtless, fit men too! Ran into your blog from Google, I think, to a post from back in 2013! Love love love your blog now, man. <3
It all starts at school with being made to go barechested during PE/Games lessons. My first experience as a 9yr old in early 90's was after starting at a new school a month after everyone, PE came around. After changing we were told it was outdoors and to line up on the school yard. Being new, the teacher hauled me out in front of the class and told me to drop my PE vest. For some reason, I don't know why, but I soon became a target and found myself being picked to strip down for 99% of the lessons. Indoors the gym had reinforced glass all along the corridor side and windows looking out. If the girls, who had their lesson separately, finished a few minutes early then they'd stand and watch us and were always keen to see who had their vests off. We were always pushed hard and it was not unusual to see boys of all ages sweat. For those who weren't picked to strip, their vests would be sticking to their backs at the end of the lesson. I guess it was the same for you Robbie?ReplyDelete
Another great piece, Robbie. The Shirts Always rule seems to be a bit of defensive me-tooism that has infected the big mainstream gyms. Many's the sportsbra-clad woman who works out at mine, and I don't think we are thereby somehow less hygienic or family-friendly. It irks me no end.ReplyDelete
My gym is open 24 hours, and I often visit late in the evening, around 10:00. It's not nearly as crowded, which is the main reason I go there that late. But also, I often take off my shirt, after a little while. No one has ever said anything to me about it that late at night – not whoever is working the front desk or another gym member. Well, a few men have asked me if anyone has commented on it (meaning whoever is at the front desk). In fact, I've inspired a few guys to strip off their shirts. They feel that comfortable after seeing me bare-chested. This shouldn't even be an issue. That political correctness crap needs to go out the window!ReplyDelete
Stay shirtless and stay proud, guys! OW-OOO!!!


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Phase II Study to Evaluate the Safety, Tolerability and Efficacy of FOLFOX + CT-011 Versus FOLFOX Alone Administered Intravenously to Patients With Colorectal Adenocarcinoma Previously Untreated for Metastatic Disease
The proposed clinical trial will be a multi-center, randomized, open label, active control
study in previously untreated patients with metastatic colorectal cancer aimed to evaluate
the safety, tolerability and efficacy of the monoclonal antibody, CT-011, administered at
3mg/kg in combination with FOLFOX chemotherapy (FOLFOX4 or mFOLFOX6) compared with treatment
by FOLFOX alone. Approximately 168 patients are planned to be enrolled to this study.
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
The primary endpoint will be the median progression free survival in patients treated with CT-011 plus FOLFOX compared to that of patients treated with FOLFOX alone.
32 months
Leonard B Saltz, MD
Principal Investigator
Memorial Sloan-Kettering Cancer Center
United States: Food and Drug Administration
May 2009
March 2013
|Memorial Sloan-Kettering Cancer Center
|New York, New York 10021
|Joe Arrington Cancer Research and Treatment Center
|Lubbock, Texas 79410-1894
|University of South Florida
|Tampa, Florida 33612
|Signal Point Clinical Research Center
|Middletown, Ohio 45042
|The Cancer Center of Huntsville, PC
|Huntsville, Alabama 35801


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My hubby boy has been traveling for work for the last 2 weeks and I have been the so called 'slomiana wdowa' meaning a 'single lady on a loose' ;). Oh the social plans I had, oh the 7 page long 'to do list' that I was planning to accomplish. Like organizing, purging, cleaning, eating donuts for dinner, binge watching Gordon Ramsey till the wee hours of 1am. You know, the regular things one does when her husband leaves for a few days or longer.
Well, let me tell you, all my planning was for nothing as literally the day T. left I got sick. Not sick with a flu or a sore throat or not even with a broken finger. I got some pretty heavy symptoms of a chronic disease that I have been dealing with for quite a white now. Quite frustrating and definitely very bad timing! Short story even shorter – out of my seven page 'to do' list I accomplished only a few things. And needless to say all my social plans for after work went down the drain turning into me running directly to subway to get home as soon as I could.
While T. was away I made an attempt to do another version of a no spend two weeks (possibly longer depending when he is back!). This mostly translates to me eating from the fridge and cupboards. T. is much more fussier than I am so some of the items (oddly shaped pasta, powdered milk, canned soup, canned fish, marinated herring, chick peas and a few other things) that I actually stocked up on are a big 'no no' for him. Well, for the last 2 weeks that's what I was mostly having. I also noticed that when it is just me I can basically spend $10 on a grocery shopping for a week and with what I already have I can eat like a queen. For some reason, when T. is here, I cannot imagine this happening. I think him being a bit more of a self acclaimed foodie and not wanting to 'deprive' himself makes us spend a lot more on groceries than we actually need to spend. But I can't win this one, so just letting it be 😉
On top of saving on groceries, that's how I saved us money:
- I sold an item on ebay and after all is said and done, I netted around $98. For packing I used supplies I saved from a package I received from Amazon. Saved $ and reused what I had on hand. Win-win! Unfortunately the money did not stay in my PayPal for too long. I spent it all on UBER rides home after work when I was not feeling well enough to go into subway. But at least it was the 'extra' money that did not come out from my checking account. So still very much thrilled about it.
- The last few days I felt better and attended a work gala event yesterday. I had a 'plus 1' so I took a girlfriend I was making plans with anyway. We had a chance to catch up and got a free three course dinner out of it 🙂
- I found $1 on a subway stairs, I looked around first and then snatched it. 😉
- While at home most of the evenings, I watched shows on YouTube and Apple TV, at the same time working on some hand sewing; I fixed some buttons, torn pockets and a ripped zipper.
- I made another batch of turmeric and vitamin C Capsules. The capsule machine paid for itself twice over already. Cannot really tell if the turmeric's power kicked in and what good it has been doing for my body but I am going to 'stick' to it for the long run.
How are YOU saving money?


text: Hi everyone! My name is Sarah. I am a 40-year-old wife, mother of two, a full time student, and CEO of my husband's business. I know that the title of CEO may seem impressive but don't be impressed. My husband has a small business making case work for different airlines. It's not like I'm the CEO of Microsoft. I am a full time student at University of Phoenix and I am going for a MBA in medical administration. I should be getting my Associates Degree in April and hope to hit the work force shorlty after. Until then, I am a stay-at-home mom. I am a native of Traverse City, Michigan. If you have never heard of Traverse City, we are located in Northwestern Lower Michigan and the home of the National Cherry Festival. We are also a home-away-from-home destination for people like Madonna, Ashton Kutcher and Demi Moore, Kid Rock, Ted Nugent, and Micheal Moore. You never know who you will see just walking down the street. Google Traverse City for pictures and see for yourself how beautiful this area is. I just got my first Android Fantasy and have lots of questions. I'm glad I'm here and hope to make connections and maybe even find answers.


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text: Not sure where this belongs, so, Mods, feel free to move it if necessary. I came from the iPhone world where iTunes would do a full backup and recovery basically automagically if I had to wipe my phone for whatever reason. Is there an app or tool that will bring my DroidX back to the state it's in now, basically fully if I were do a wipe/hard reset. I am planning on doing some testing and screenshots for Android support for my employer and while this is my personally owned phone, I expense the service back to them. Any recommendations for full backup Sw?


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Thursday, 29 August 2013
How To Deal With Somali Pirates
In 2010 Somali pirates captured a Russian oil tanker.
The European Union, which patrols these waters, refused to interfere claiming that they feared there could be casualties.
Then Russian Navy Commandos freed the crew & recovered the tanker. This videotape shows what happened after the Russians captured the Somali pirate ship.
The Russian commandos spoke to each other in Russian, but spoke to the pirates in English. The Russians also communicated with what the pirates understand best of all - force & strength.
The anti-piracy laws of the18th & 19th centuries provided that the captain of a ship, which captured pirates, has the right to decide what to do with the pirates. The traditional result was a quick hanging.
Today the United Nations is trying to take jurisdiction over international waters through what they call the "Law fo the Sea Treaty" (LOST).
Apparently the Russians favored the previous law.
They moved the pirates back to their own pirate ship, after searching it for weapons & explosives. Then they left the ship & fired upon it with the pirates on board to it.
They sank the pirate ship and all of the pirates without any United Nations resolutions, court proceedings or lawyers etc.
There was no "collateral damage".
Posted by L.A. Fant at 16:59
Labels: Islam, Muslim, Russia, Somali Pirates
Subscribe to: Post Comments (Atom)


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Endothelial dysfunction contributes significantly to acute renal failure (ARF) during inflammatory diseases including septic shock. Previous studies have shown that activated protein C (APC) exhibits anti-inflammatory properties and modulates endothelial function. Therefore, we investigated the effect of APC on ARF in a rat model of endotoxemia. Rats subjected to lipopolysaccharide (LPS) treatment exhibited ARF as illustrated by markedly reduced peritubular capillary flow and increased serum blood urea nitrogen (BUN) levels. Using quantitative two-photon intravital microscopy, we observed that at 3 h post-LPS treatment, rat APC (0.1 mg/kg iv bolus) significantly improved peritubular capillary flow [288 ± 15 μm/s (LPS) vs. 734 ± 59 μm/s (LPS+APC), P = 0.0009, n = 6], and reduced leukocyte adhesion (P = 0.003) and rolling (P = 0.01) compared with the LPS-treated group. Additional experiments demonstrated that APC treatment significantly improved renal blood flow and reduced serum BUN levels compared with 24-h post-LPS treatment. Biochemical analysis revealed that APC downregulated inducible nitric oxide synthase (iNOS) mRNA levels and NO by-products in the kidney. In addition, APC modulated the renin-angiotensin system by reducing mRNA expression levels of angiotensin-converting enzyme-1 (ACE1), angiotensinogen, and increasing ACE2 mRNA levels in the kidney. Furthermore, APC significantly reduced ANG II levels in the kidney compared with the LPS-treated group. Taken together, these data suggest that APC can suppress LPS-induced ARF by modulating factors involved in vascular inflammation, including downregulation of renal iNOS and ANG II systems. Furthermore, the data suggest a potential therapeutic role for APC in the treatment of ARF.
- two-photon intravital microscopy
- endotoxin
acute renal failure (ARF) is a common complication in septic patients, with an incidence reported to be ∼20–50% (35, 36). The mortality rate associated with ARF in septic patients is 75% compared with 45% in patients without sepsis (38). Despite advances in supportive care with appropriate antibiotic administration and maintenance of systemic hemodynamics, coupled with the lack of proven pharmacological intervention, mortality rates for ARF patients have remained unchanged (50).
During sepsis, a broad array of soluble factors are altered including the serine protease, protein C (PC). Reduction in plasma levels of PC have been shown to be prognostic for sepsis and sepsis severity (reviewed in Ref. 11). Studies have also suggested that low PC levels are predictive of early death in a rat model of polymicrobial sepsis (14). Exogenous administration of activated PC (APC) has been shown to reduce ischemia-reperfusion-induced renal injury and to attenuate microcirculatory dysfunction (16, 26). These studies support the significance of the PC pathway in reducing organ dysfunction, which is further exemplified by the efficacy of recombinant human APC in the treatment of severe sepsis (1). However, the precise role of APC in attenuating sepsis-induced ARF is unclear.
Escherichia coli lipopolysaccharide (LPS) administration in rodents has been used to mimic sepsis-induced ARF (5). Although LPS challenge does not exhibit all of the manifestations of clinical sepsis, the hemodynamic changes induced by LPS result in alteration of renal blood flow and glomerular filtration rate (GFR) producing loss in renal function. The pathogenesis of ARF secondary to endotoxemia has been attributed to impaired hemodynamics caused by multiple mechanisms, including production of large amounts of nitric oxide (NO) and proinflammatory cytokines, along with enhanced renal vasoconstriction. In addition, leukocyte activation and microvascular dysfunction following kidney injury appear to play important roles in mediating renal dysfunction and ARF (28).
Substantial evidence from clinical and experimental studies demonstrates the involvement of angiotensin II (ANG II), an effector of the renin-angiotensin system (RAS), in various biological processes that lead to deterioration of normal renal function. In response to peripheral vasodilation mediated by increased NO, counterregulatory mechanisms causing RAS activation lead to increased angiotensin production via action of angiotensin-converting enzyme (ACE), which further predisposes the kidney toward enhanced injury. Although various reports suggest that APC might reduce NO by suppression of inducible NO synthase (iNOS) activation (17), its effect on renal iNOS and on the RAS system is unknown.
In the present study, we explored the role of APC in modulating the response to injury by LPS in the kidney. We demonstrate that during early endotoxemia, APC suppresses the induction of renal iNOS and ANG II, improves renal blood flow, and reduces leukocyte activation and adhesion. In addition, APC also confers renoprotective actions at late-stage endotoxemia as evidenced by reduced plasma blood urea nitrogen (BUN) levels and complete restoration of renal blood flow. Overall, our studies suggest a role of APC in ameliorating ARF possibly by its ability to limit both peripheral vasodilatation and paradoxical renal vasoconstriction. Moreover, our data suggest that APC offers a potential therapy for sepsis-induced ARF.
Animals and surgical procedures.
Male Sprague-Dawley rats (Harlan, IN) weighing 250–300 g were used in the study. The rats were acclimatized to the laboratory conditions for at least 7 days following their arrival. The night before surgery rats were denied access to food but had access to water. On the day of experiment, the rats were placed in an induction chamber and received a mixture of low flow oxygen and 5% halothane for induction of general anesthesia. Once induced, they were placed on a Rodent Anesthesia Circuit (Kent Scientific, Torrington, CT) and maintained on 1.5% halothane and low flow oxygen. Through a left groin incision, cutdowns were performed on the left femoral vein for catheterization with polyethelene cannulas (PE-50, internal diameter 0.58 mm, external diameter 0.965 mm, Clay Adams Division, Becton Dickinson and, Parsippany, NJ).
Endotoxemia was induced by administration of E. coli LPS (10 mg/kg iv infusion for 30 min; LPS W E. coli 0111:B4, Sigma, St. Louis, MO) using the left femoral vein catheter as described previously (37). The animals were then randomized into two groups; sham-treated and LPS-treated animals at the time of surgery. The animals in the LPS-treated group were then further divided into vehicle- and APC-treated groups. The control group received pyrogen-free saline infusion (1 ml/kg). For treatment studies, recombinant rat APC was produced in AV12-664 cells and then activated with recombinant rat thrombomodulin/bovine thrombin complex essentially as described previously for human APC (12). In the APC-treated groups, rat APC (100 μg/kg bolus iv) was administered at the time of administration of LPS. The hemodynamic recordings were done at 3 h post-LPS administration. Animals were killed at 3-h time point for collection of kidney tissue (mRNA and protein analysis) and a blood sample was collected for analysis just before death.
For 24-h studies, rats received an intraperitoneal injection of LPS (20 mg/kg). This concentration was based on a dose response that resulted in elevated BUN and no mortality at 24 h. APC (2 mg/kg, administered at 0 and 12 h post-LPS treatment) was used to cover the entire exposure owing to its short half-life. All experimental methods were approved by the Institutional Animal Care and Use Committee and were in accordance with the institutional guidelines for the care and use of laboratory animals.
Intravital 2-photon imaging.
Intravital two-photon microscopy was performed as previously described (7). Live renal imaging in rats at 3 h posttreatment was performed using a Bio-Rad MRC-1024MP Laser Scanning Confocal/Multiphoton scanner (Hercules, CA) with an excitation wavelength of 800 nm through a Nikon Diaphot inverted microscope utilizing a ×60 NA 1.4 lens. Assessment of functional renal injury in the form of vascular permeability defects and disruptions in blood flow was achieved utilizing a high molecular weight dextran (HMWD) that is not filtered by the glomerulus under normal conditions (500 kDa, 7.5 mg/ml in 0.9% saline; Molecular Probes, Eugene, OR), and a low molecular weight dextran (LMWD) that is freely filterable across the glomerulus (3 kDa, 20 mg/ml in 0.9% saline; Molecular Probes). To differentiate the two dextrans, the HMWD dextran was labeled with fluorescein (Molecular Probes) while the LMWD was labeled with Texas Red (Molecular Probes). The left kidney of the anesthetized rat was imaged following exteriorization through a retroperitoneal window via a flank incision. Images were analyzed with Image J software (ImageJ, National Institutes of Health, Bethesda, MD). Approximately 10–12 images, every 3 min, were collected for each animal examined. For studies examining leukocytes in the microvasculature, images obtained were analyzed in a 4 × 4 grid. Leukocytes were identified by their characteristic uptake of the Hoechst nuclear stain (Hoechst-33342, 400 μl, 1.5 mg/ml in 0.9% saline; Molecular Probes). Leukocytes in the microvasculature were classified into three subtypes namely 1) free flowing: presence of leukocyte during real-time imaging in a grid for less than or equal to two frames, 2) static or adherent: attached to microvascular endothelium with no movement, and 3) rolling: appearance along endothelial surface for three or more frames in a grid. For quantifying microvascular leakage, images obtained were analyzed in a 4 × 4 grid, and each grid section (16 per image) was scored for the presence or absence of dextran extravasation for both large and small dextrans. To avoid cross-over bias from adjacent grid images, each grid was individually scored in a random blinded fashion. Calculation of blood cell velocities as an index of blood flow was based on previously published modified line-scan method (27). Only vessels of similar diameter (8–10 μm), continuous horizontal segment length of at least 50 μm, and a minimum distance of 50 μm from an angle or tortuousity were chosen for velocity calculations as increasing diameter and tortuousity results in increased or turbulent flow under physiological conditions, respectively. Additionally, trigonometry was used to correct for vessels not running perfectly horizontally up to angles of 30°, beyond which vessels were excluded.
Cytokine and BUN measurements.
Arterial blood was collected into EDTA tubes and the plasma supernate was collected and stored frozen until analysis. Measurements of IL-6 and IL-18 were done by immunoassay using the Rodent Multi-Analyte Profile (Rules Based Medicine; Austin, TX) as previously described (14). BUN in plasma was determined using a Hitachi 911 clinical chemistry analyzer (Roche Diagnostics, Indianapolis, IN).
Quantitative real-time PCR.
Total RNA was purified from kidney tissue samples that had been preserved in RNA-later (Ambion, Austin, TX) using the RNeasy kit (Qiagen, Valencia, CA). RNA integrity was determined by agarose gel electrophoresis. DNase-treated total RNA was used for first-strand cDNA synthesis primed with random hexamers using the Superscript II cDNA synthesis system (Invitrogen, Carlsbad, CA). Parallel control reactions (−RT) were performed in the absence of reverse transcriptase. Purified total RNA was analyzed by quantitative real-time PCR (qPCR) with an ABI Prism 7900HT Sequence Detection System. An internal standard curve was generated by serial dilution of an appropriate cDNA reaction and used for relative quantification. TaqMan Gene Expression Assays for iNOS, ACE1, ACE2, AT2, and angiotensinogen (Agt) and for the 18S rRNA eukaryotic endogeneous control kit were purchased from Applied Biosystems (ABI, Foster City, CA). The assay for 18S rRNA was used to normalize to the gene of interest (GOI). Normalized GOI quantities were then used to calculate treatment group averages and percent expression change relative to the sham group, which was defined as 100%.
Determination of concentration of ANG II in rat kidney tissue.
ANG II levels were measured using the kit supplied by Phoenix pharmaceuticals (Belmont, CA) following the manufacturer's instructions. To determine renal ANG II levels, tissue samples were homogenized in ice-cold methanol containing 0.1% trifluoroacetic acid (TFA). The homogenate was centrifuged at 2,000 g for 10 min at 4°C. Tissue ANG II concentration was measured after extraction through the Sep-Pak C-18 column supplied by the manufacturer (Phoenix Peptide). The peptide was eluted very slowly with 3 ml of 60% acetonitrile in 1% TFA and the eluant was collected in a polypropylene tube. The eluant was evaporated using a SpeedVac Concentrator Savant SVC 100 H (Instruments, Formingdale, NY). The residue was then dissolved in 250 μl of RIA buffer and two aliquots of 100 μl were assayed for ANG II according to manufacturer's specifications. Results were normalized to the amount of protein per sample, as determined by BCA assay (Pierce, Rockford, IL). The rat ANG II assay has no cross-reactivity with endothelin-1, substance P, [Arg8]-vasopressin, and ANG I peptides.
Determination of concentration of NOx in kidney tissue.
The concentration of NO byproducts NOx (nitrate + nitrite) was determined in kidney tissue samples as previously described (13). Briefly, kidney tissue was homogenized with cold PBS on ice that inhibited the activity of NOS ex vivo. The homogenate was spun down (3,000 g, 5 min, Beckman) and the supernatant was collected. The NOx concentration was then determined in the supernatant using standard Griess reaction method. Absorbance was measured at 540 nm using a plate reader and converted to NOx concentration using a nitrate standard curve and expressed as micromoles per gram of protein in tissue. Protein in the supernatant obtained from each sample was determined using BCA assay (Pierce).
Statistical analyses.
Data are presented as means ± SE. The biochemical data were analyzed by one-way ANOVA using JMP5.1 software (SAS Institute). After obtaining a significant F value, post hoc Student t-test was performed for inter- and intragroup comparisons. Statistical significance was realized at P ≤ 0.05 to approve the null hypothesis for individual parameters.
APC improves microvascular blood flow following LPS-induced kidney injury.
Intravital two-photon microscopy was used to quantify LPS-induced functional defects on the renal vasculature and the effect of APC treatment. Administration of LPS post-3 h caused frequent occurrence of obstructed peritubular capillary flow, tubular damage, and tubular necrosis (Fig. 1B). However, following treatment with APC (0.1 mg/kg bolus), these rats exhibited rapid movement compared with the sluggish, turbulent flow that was observed following LPS administration (Fig. 1C). Please refer to supplementary material for this article to view the movies M1 (sham-treated rat), M2 (LPS-treated rat), and M3 (APC-treated rat; the online version of this article contains supplemental data). To quantify these protective effects of APC during endotoxemia, blood cell velocities were measured using the modified line-scan method (27). As shown in Fig. 2, administration of LPS significantly reduced erythrocyte flow rate by ∼71% compared with the sham group [1,023 ± 96 μm/s (sham) vs. 289 ± 15 μm/s (LPS)]. Furthermore, in the LPS-treated rats, few regions of near normal blood flow were observed. On treatment with APC, rats exhibited significantly improved erythrocyte flow rates [288 ± 15 μm/s (LPS) vs. 734 ± 59 μm/s (LPS+APC), P = 0.0009] compared with LPS-treated rats. These data suggest that treatment with APC aids in restoration of blood flow as early as 3 h-post endotoxin administration.
Effect of APC on leukocyte adhesion and rolling following LPS-induced kidney injury.
Since vascular endothelial dysfunction is an early event in sepsis, we quantified the effect of LPS administration on the dynamic nature of leukocyte interaction along the renal microvascular endothelium using two-photon intravital microscopy. In the LPS-treated rats, 3 h postadministration, there was evidence of increased leukocyte adhesiveness to the endothelium both in terms of fully adherent or static leukocytes (∼6-fold increase) in the microvasculature as well as intermittent adhesion (rolling) within the microvasculature (∼8-fold increase; Fig. 3). Consequently, the percentage of total free leukocytes was decreased in LPS-treated animals (∼82%). In contrast, APC treatment during endotoxemia demonstrated a significant reduction in total number of static (Fig. 3A) and rolling (Fig. 3B) leukocytes. As shown in still frames from the two-photon imaging, the adherent leukocytes can be easily visualized (arrows) in the microvasculature of LPS-treated animals (Fig. 3C) and largely absent in the LPS plus APC-treated animals (Fig. 3D). Thus APC significantly suppresses LPS-induced leukocyte activation by reducing absolute adherent and rolling leukocytes.
Effect of APC on tubular function and microvascular permeability.
LPS is known to cause a pronounced defect on endothelial permeability. Furthermore, APC has been shown to attenuate barrier disruption in cultured cells to ligands such as thrombin (10). Hence, to determine whether APC could protect endothelial barrier disruption in vivo, we utilized qualitative intravital microscopy and determined leakage of LMWD and HMWD as indicators of endothelial permeability. In the LPS-treated rats, we observed apparent leakage of both LMWD and the HMWD from the renal microvasculature (Fig. 1B), with leakage of LMWD (red) more pronounced than HMWD. In APC-treated rats, we observed no apparent leakage of either LMWD or HMWD in any animal (Fig. 1C).
Tubular function was also assessed by determining the time lag for the endocytic uptake of LMWD by proximal tubules. On timed analysis of the appearance of the LMWD in the proximal tubules postinjection, we observed that there was a time lag (∼10 min) in the uptake of LMWD compared with sham group where the uptake was instantaneous. On APC treatment, the uptake of LMWD by the proximal tubule was restored (Fig. 4). Therefore, APC appears to protect from LPS-induced kidney injury by maintaining endothelial permeability, glomerular filtration, and proximal tubular function.
As has been reported previously in humans (44) and in model systems (17), we found that APC did prevent the LPS-induced hypotension in our studies [mean arterial pressure (MAP) of 96.5 ± 2.1 mmHg in sham, 65.2 ± 2.1 mmHg in LPS, and 98.2 ± 3.8 mmHg in LPS+APC]. However, volume expansion by infusion of 2 to 3.5 ml of saline resulted in an increase in MAP of 25.6 ± 5.6 mmHg, similar to the APC effect, but did not significantly alter tubular dysfunction or leukocyte margination. These data suggest that the protective effects of APC were not secondary to prevention of hypotension.
APC reduces iNOS mRNA and NOx levels.
Administration of LPS significantly increased iNOS mRNA levels in the kidney by ∼16-fold compared with sham-treated group (Fig. 5A). In contrast, APC treatment in these rats significantly suppressed iNOS mRNA induction (P < 0.00001) in the kidney. In addition, the LPS+APC group was not significantly different than the sham-treated group.
To further examine the effect of APC on LPS-induced NO activation, we measured the concentration of NOx levels in kidney tissue. Similar to the effect on iNOS mRNA induction, APC completely abolished the LPS-induced increase in NOx levels [147.3 ± 29.2 μmol/g protein (LPS) vs. 89.5 ± 5.6 μmol/g protein (LPS+APC)] in Fig. 5B.
Effect of APC on angiotensin system during endotoxemia.
Numerous studies suggest that abnormal activation of the RAS system in the kidney, leading to excess production of ANG II, results in tubulointerstitial injury and subsequent loss of renal function (24). Hence, we speculated that APC might be inhibiting the renal dysfunction associated with endotoxemia by suppressing ANG II production. As shown in Fig. 6A, LPS treatment caused a significant increase in ANG II peptide levels, which was suppressed following APC treatment in these animals. To further examine these effects, we determined the relative levels of the ANG II precursor, Agt, and the converting enzymes ACE1 and ACE2. We observed that LPS induced approximately fivefold increase in the mRNA level of the Agt (Fig. 6B), which was significantly reduced following APC treatment. LPS also increased ACE1 mRNA levels (Fig. 6C), while downregulating ACE2 (Fig. 6D). In contrast, APC treatment significantly increased ACE2 mRNA levels and suppressed the induction of ACE1. This is further evident by the fact APC treatment doubled the ACE2/ACE1 ratio compared with the LPS-treated group. These data suggest that APC suppresses LPS-induced RAS activation by blocking the induction of Agt and ACE1 and by increasing ACE2 resulting in diminished ANG II levels in the kidney.
Recent studies have shown that Agt is upregulated at the promoter level by IL-6 (18). Moreover, IL-6 is induced by ANG II (21) and suppressed by RAS inhibition (31). Therefore, we examined whether the ability of APC to suppress Agt might be related to an ability to suppress IL-6. We found that the level of IL-6 in the plasma was significantly increased following endotoxemia, but significantly reduced by APC treatment (∼69%, P < 0.008). Moreover, the level of IL-6 mRNA expressed in the kidney was reduced by 35% (P < 0.02) by APC treatment.
Effect of APC on renal function post-24 h endotoxemia.
The above data provided mechanistic understanding for the early effect of APC on LPS-induced renal dysfunction. To provide additional evidence of a sustained benefit, we examined the effect of APC at 24 h after endotoxemia. For these studies, we utilized the rat model of intraperitoneal administration of LPS that induces more severe renal injury compared with intravenous infusion of LPS. Measurement of peritubular capillary flow using intravital microscopy and plasma BUN levels was used as indexes to analyze the effect of APC on LPS-induced kidney dysfunction at 24 h posttreatment. Figure 7, A and B, depicts the effect of APC on the renal vasculature as observed utilizing intravital two-photon imaging. As described in Fig. 1 for the intravital microscopy measurements at 3 h, LPS-induced sluggish erythrocyte flow rates along with a lag in endocytic uptake of the low molecular weight dextran by the proximal tubules, 24 h posttreatment. In contrast, APC-treated rats exhibited faster flow rates, as indicated by rapid streaks and improved tubular function. Quantification using the line-scan method as shown in Fig. 7C shows that APC treatment completely restored LPS-induced suppressed of renal flow (P = 0.001). By 24 h, LPS treatment had resulted in a significant elevation in BUN (Fig. 7D), which was significantly reduced to the levels observed in sham-treated rats following APC treatment. At this time point, there was no significant reduction in MAP from the LPS treatment. These data provide evidence that the protective mechanisms observed with APC following early endotoxemia result in improved renal function in late-stage endotoxemia.
The pathophysiology of ARF involves a complex interplay between various processes, including tubular and endothelial cell injury and inflammation. Microvascular dysfunction following injury to the kidney appears to play a key role in initiating and extending tubular injury and is associated with significant inflammatory activation that contributes to the extension of renal dysfunction (28). In patients with sepsis, there is an increased incidence of ARF (43) and damage to the endothelium, resulting in increased vascular permeability, leukocyte adherence, and loss of normal endothelial function, has been well documented (29). We demonstrated the ability of APC to modulate these measures of endothelial dysfunction associated with ARF. We observed that APC ameliorates renal dysfunction during both early and late endotoxemia, coincident with the attenuation of NO generation and perturbation of the RAS.
Tubular epithelial cell function and renal blood flow play a significant role in regulating renal function by modulating GFR (46). Using two-photon imaging, the present study revealed a reduction in cortical peritubular capillary flow 3 h post-LPS administration. Similar results have been reported using laser doppler studies in rats following endotoxemia (25). Besides diminished flow, we observed defective tubular function as revealed by reduced uptake of LMWD by the epithelial cells of the proximal tubules. However, administering a single bolus injection of APC improved renal function by increasing peritubular capillary flow as well as tubular function in these endotoxemic rats as early as 3 h posttreatment. In addition, APC also suppressed renal expression of the proinflammatory cytokine IL-6 and the circulating levels of both IL-6 and IL-18 (data not shown). Detection of biomarkers such as proinflammatory cytokines released in response to renal injury have been suggested to provide more compelling evidence of kidney injury at the early phase of disease progression (33, 40), e.g., more so than serum creatinine, which exhibits a time delay for a detectable increase postinjury (32). Therefore, these data suggest that APC can alter renal injury by modulating microvascular flow and inflammatory stimuli and change early plasma markers suggestive of renal injury.
APC functions both as a feedback inhibitor of thrombin generation (8) and as an anti-inflammatory and cytoprotective agent via EPCR/PAR-1 receptor signaling (19). In our studies, LPS administration caused coagulation activation at the 3-h time point as indicated by reduced plasma fibrinogen levels. However, at the relatively low dose used, APC treatment did not prevent the reduction in fibrinogen levels by LPS. Similarly, in a human study of recombinant APC in a model of endotoxemia, little effect on coagulation markers was observed (6). These authors further speculated that compared with other anticoagulants, the effect of APC may be less driven by its anticoagulant activity and more by its role as an endothelial function modulator through EPCR/PAR-1. In addition, Hoffmann et al. (15) demonstrated that thrombin inhibition alone could not reduce endotoxin-mediated leukocyte adhesion and rolling. Overall, the data suggest that the anti-inflammatory properties of APC may be more important than the anticoagulant properties for the observed protection against LPS-induced renal injury.
The pathogenesis of sepsis-induced ARF is incompletely understood but involves systemic vasodilation leading to reduced systemic vascular resistance, mediated by iNOS activation (20). The impact of NO on tubular function and GFR is well established (25, 41). Furthermore, inhibition of iNOS by l-NIL has been shown to preserve renal cortical perfusion during endotoxemia (42). The relevance of the NO pathway in the pathogenesis of sepsis is further supported by the fact that iNOS knockout mice do not exhibit hypotension on LPS treatment and also do not increase NO synthesis following a septic insult in these knockout mice (23, 45). In the present study, APC treatment downregulated LPS-induced increased renal iNOS mRNA and NOx levels along with restoring tubular function and renal blood flow. Therefore, downregulation of iNOS-derived NO by APC may account for improved peritubular capillary flow and function.
The kidney possesses its own RAS system that acts independently of the circulating system and is pivotal in regulation of renal function (2). A key element of the RAS system is the enzyme ACE1 that cleaves the inactive precursor peptide ANG I to active ANG II that induces vasoconstriction. Recently, ACE2 which is a homolog of ACE1 has been identified that hydrolyzes ANG II to the vasodilator Ang (1–7), thus regulating the net level of ANG II and facilitating the mitigation of the biological actions of ANG II (9). As a counterregulatory measure to peripheral vasodilation, subsequent RAS activation culminates to maintain hemodynamic stability, inducing renal vasoconstriction that in turn further contributes to the pathogenesis of sepsis-induced ARF (4). This unique vasoconstrictor response of the renal vasculature contrasts with the observed vasodilation of the mesenteric, intestinal, hepatic, splenic, and nonsplanchnic vascular beds during sepsis and LPS administration (39). Studies in both humans and animals suggest that the observed renal vasoconstriction may result from impaired endothelium dependent vasodilation (3, 34). In the present study, LPS administration produced increased renal vasoconstriction observed by two-photon imaging and as demonstrated by elevated renal ANG II levels. This increase in ANG II levels by LPS was also accompanied by elevated Agt and ACE1 but diminished ACE2 expression. These results are in agreement with Yamaguchi et al. (48) where they demonstrated elevated ANG II and ACE levels post-3 h endotoxemia. Interestingly, treatment of these endotoxemic animals with APC blocked the LPS-induced activation of the renal RAS components. We speculate that the ability of APC to suppress the local synthesis of ANG II in the kidney by upregulating ACE2 and inhibition of Agt and ACE1, and also by feedback inhibition of Agt, may contribute to the observed improvement in renal function during endotoxemia. Similar observations were made by Ye et al. (49) where they suggested that increased ACE2 expression coupled with low ACE activity may be renoprotective in diabetes. Also, ACE inhibitor captopril has been shown to prevent LPS-induced decline in renal blood flow and GFR (22). In addition, since ANG II has been shown to induce neutrophil accumulation in vivo (30), reduction of renal ANG II levels by APC may contribute to its ability to suppress leukocyte adhesion in the present study. Collectively, these data suggest a role of APC in modulating the renal RAS system to regulate renal function in vivo.
Peritubular capillary dysfunction during LPS-induced injury is a progressive phenomenon that has been shown to precede the development of ARF (47). We observed peritubular capillary dysfunction following LPS treatment as early as 3 h along with induction of IL-6 and IL-18 levels but no detectable increases in BUN levels. However, at late stage of endotoxemia (24 h), we observed elevation in plasma BUN levels along with diminished renal blood flow. These observations suggest that peritubular dysfunction following LPS induction early on can contribute to loss of renal function evident at late-stage endotoxemia. Interestingly, APC treatment mitigated the peritubular dysfunction during both early- and late-stage endotoxemia. Since, LPS administration does not reproduce the hyperdynamic stage of sepsis; further studies may be required to elucidate the role of APC in improving peritubular capillary flow in a more relevant sepsis animal model such as CLP.
Overall, the data presented in the current study demonstrate the ability of APC to protect the renal microvasculature from injury. APC may improve renal function during endotoxemia by restoring impaired renal hemodynamics possibly by suppressing local NO and the ANG II system, as well as inhibiting leukocyte-endothelial cell interactions. In view of the important role of endothelial dysfunction in acute renal injury, our data suggest the potential for the clinical use of APC in the treatment of sepsis-induced ARF.
The authors disclose that A. Gupta, D. T. Berg, B. Gerlitz, and B. W. Grinnel are employed by Eli Lilly and Co. which produces recombinant human APC.
We gratefully acknowledge R. Sandoval for assistance with intravital two-photon imaging. We also thank J. Brunson, S. L. Hilligoss, and D. B. McClure for assistance with rat APC cell culture.
The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
- Copyright © 2007 the American Physiological Society


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Orla Barry: Is the child I am raising really my biological son?
I have a three-year-old son with my girlfriend of five years and I am pretty happy except for one niggling doubt. Four years ago she broke it off with me out of the blue for a few months. At the time she never really said why, just that she was having doubts about us.
We got back together and shortly afterwards she found out she was pregnant. I didn't think too much about it because I was so shocked at the idea of being a father.
Since our son was born, we became closer than ever. He is undoubtedly the best thing that has happened to me.
Everyone jokes that he is the head off his mother and to be honest I don't see myself in him at all.
Recently we got talking about why we broke up and she admitted that an old boyfriend had come back on the scene.
She said she got confused and to avoid the confusion had ended the relationship.
She said I was also very possessive and, if I'm honest, I often still wonder what she saw in me. When I pressed her about it, she admitted they had slept together, although it happened after our break-up.
Now I find myself looking at our son and wondering if it's possible he's not mine. It would cut me up to find I wasn't the father and most of the time I just try and shove the thought away.
I remember when she first told me she was pregnant asking if I was definitely the father and she went berserk.
Recently I said it to a close friend who said you can do a paternity test at home without involving her just to prove it. If I do that and he's not mine, I don't know what I would do.
Orla replies:
You could just forget about it but somehow I suspect you're not the type of chap who can let things lie. It's more likely this is a sign of your possessive nature flaring up again.
Sneaking around behind her back conducting paternity tests might give you the answer but it won't solve the underlying problem of your own insecurity in this relationship. Better come clean now and discuss what's on your mind or resolve never to broach this subject again.
It makes perfect sense that your girlfriend went berserk when you questioned who the father of the child might be, although in hindsight, you were right to query it. After all, she did sleep with someone else around this time.
There are obvious questions you can ask about the use of protection, although in my experience there are no absolute failsafe methods. She is the only person who can adequately address your doubts and, of course, there is the possibility that these are thoughts she doesn't even wish to consider.
Is there a chance that she herself might have wondered and never fully clarified the matter?
Having a child that doesn't look like you is not an indication that the child is someone else's. Sometimes it can take a good few years before you spot family resemblances.
Angry and all though the questions might make her, she did sleep with someone else after you broke up and, in my book, that gives you the right to at least address the issue again.
The problem facing you is what you will do if the answer is one you don't want to hear. You say your son is the best thing to have happened to you and I wonder if he is not yours, will you walk away?
In this little boy's mind you are his father and even if you don't share the same genes you have been there in every other way. I know it's impossible to plan what your reaction will be, but in this case the needs of this boy should come first.
That said, if there are doubts about the paternity of your son, I don't imagine they will just disappear.
For medical reasons it may well matter that you both know who his birth father is. You have already talked about this with a friend of yours, so you have aired the issue. Can you guarantee that in a few years' time, this won't come back to haunt you or your little boy?
Children who are adopted are often left with an underlying sense of insecurity about their origin. Only loving adoptive parents can ensure that this insecurity doesn't have a lasting impact.
Better to have the matter cleared up now than in a few years' time when he is far more sensitive to what's happening.
I wonder why your girlfriend told you about the break-up and her old boyfriend recently. Do you think she was trying to raise the issue?
If there are doubts then she will also be living with a lie which is going to become more of a burden as the years pass.
I do think there is another issue here and that is your own insecurity in this relationship. She broke it off once before, partly because of your possessiveness. The fact that she refers to this now shows how much this characteristic bothered her.
Do you still wonder what she sees in you? Are you wondering if she is still with you because of this boy? Insecurities like this cannot be solved by the assurances of the other partner.
These are issues you are going to have to tackle yourself. If you are together five years it sounds like the relationship is on solid footing. You need to work on improving your own self-belief.
In the meantime, it's only fair that you air your doubts with your girlfriend now. My understanding of paternity tests, if you go that route, is that they require the consent of both adults. It's not quite a Jeremy Kyle-style showdown. Kits can be sent to the family home but, to receive results, you have to send swabs back with letters of consent.
After that it is a simple case of waiting for the results.
Just be sure to remember you have always been a father to this boy and his needs should be paramount whatever a test result might decide.
Health & Living


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Carmelo Anthony and LeBron James were nearly matching each other miss for miss. But with the game on the line, James connected for some big buckets and Anthony misfired again.
Anthony had a chance to tie it, but his three-pointer with 1.5 seconds left rattled and rimmed out, and the Knicks lost their sixth straight game, 90-87, to the Cavaliers Thursday night at Madison Square Garden. They're 4-16, the worst record after 20 games in franchise history.
Anthony finished 4-for-19 with nine points. In the fourth, he was scoreless, missing all four of his shots. In Tuesday's loss to the Nets, he missed two three-pointers with a chance to tie at the finish and was 1-for-9 in the fourth quarter.
Tim Hardaway Jr. led the Knicks with 20 points. Amar'e Stoudemire added 18.
Kyrie Irving torched the Knicks for 37 points, including a layup with 10 seconds left for the final points. James was 7-for-17 and scored 19. He gave the Cavaliers (10-7) the lead for good with a three-pointer with 3:54 left.
The Knicks led by 11 in the first half and seven in the fourth but couldn't close out the game.
It was a wild ending that featured a controversial eight-second violation on the Knicks with 1:11 left and Cleveland up 88-87. But Irving missed and Anthony rebounded it. Derek Fisher was calling for a timeout, but no one heard him.
Fisher didn't get the timeout he wanted in the closing seconds Tuesday. He made his way out to halfcourt and was waving his arms for time until it was finally granted with 41 seconds to go.
Out of the timeout, instead of Anthony or Stoudemire getting the ball, Shane Larkin took the shot and missed a runner. Anthony couldn't convert on a tip-in with 32 seconds remaining.
The Cavaliers called timeout and fittingly got the ball to Irving, who had been giving the Knicks fits all night. He put the final nail in the coffin, driving past Iman Shumpert and hitting a floater high off the backboard to give the Cavs the three-point lead with 10 seconds left.
The Knicks rode Stoudemire early in the fourth, and he delivered with a huge dunk over Anderson Varejao and a tough layup inside that made it 79-72 with 8:57 left.
But the Knicks' lead was gone five minutes later, after James drilled a three with 3:54 left to make it 86-85 Cavaliers. On the ensuing trip, Irving stole the ball from Jose Calderon and fed James for a breakaway dunk with 3:25 to go.
After Stoudemire scored, the Knicks had several chances to regain the lead. But Stoudemire and James missed inside, and then Anthony was called for a travel as he went in for a layup. James missed on the other end, but Stoudemire's short hook rimmed out with 1:40 left.
The Knicks' win in Cleveland on Oct. 30 easily was their best of the season, and not a game that Cavaliers coach David Blatt wants to relive.
"When I feel like being particularly masochistic, I go back and look at that game,'' Blatt said before Thursday night's game. "Given my experience, I try to avoid that whenever I can. You look at certain elements of a game. To sit and watch the whole game is almost too painful.''
The Knicks were looking for a repeat performance, and got off to a much better start than they had in their previous three games, when they trailed by double figures in the first half of all three. The Knicks reversed that trend against the Cavaliers, with the bench providing a spark.
Hardaway was 2-for-12 with four points in the previous two games, but he gave the Knicks a lift. He scored 11 points during a 13-0 run that gave the Knicks a 37-27 lead with 7:54 left in the half. Hardaway buried three three-pointers in the run and scored 16 points in the half.
The Knicks' reserves outscored the starters 29-24 in the opening half, helping the Knicks to a 53-50 lead at the break.


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|Bengali Name :
|Sada Buk Machhranga (সাদা বুক মাছরাঙ্গা).
|Common Name :
|White throated kingfisher, White breasted kingfisher, etc.
|Scientific Name :
|Halcyon smyrnensis
|Family :
Today I am going to write about the White-throated kingfisher bird which is also known as White-breasted kingfisher. It is native to the Asian region (lower part of Asia). Similar to the other kingfisher birds in Bangladesh, this is known as Machhranga (মাছরাঙ্গা) in general. Scientific name of the bird is Halcyon smyrnensis from the family Halcyonidae.
Though it's a small bird, but it is a large kingfisher. The black side, wing, and the tail of the bird is bright blue in color. The shoulder, head, and lower portion of the front is chestnut color. The bill is much larger in size and the color is red (sometimes near to orange). The color of the foot is also red. The throat and breast's color is white (which is the reason for its English name). Both male and female birds are similar.
Though it is a kingfisher bird, but it doesn't rely on preying only the fishes. Rather the small reptiles, crabs, earthworms, insects are also in its dieting list along with the fishes and frogs. From the report its found that the bird sometimes try to prey on other small birds (or chicks) as well. And of course this bird is a natural expert fish catcher as it is a Kingfisher. They are accurate and extremely fast while preying. They can also hover for a short period of time on air.
As this bird is having a varied range of dieting, that's why it is also found far from the water as well. I have seen this bird at the middle of a jungle at Rema-Kalenga (রেমা-কালেঙ্গা) during my trekking. There were hardly any water near that place. They use to perch on open spaces like pole beside pond, electric wires, tree branch, etc.
White throated kingfisher birds are very noisy (specially during the breeding season). They use to make nest on the earth bank which can be beside a river, pond, or any other suitable places. The other birds of prey do not bother this kingfisher for it's long bill. In other word it doesn't have too many enemies.
Photos of this article were taken from Bangladesh during 2014 & 2015:
1) 25 October 2014: Botanical Garden, Dhaka (বোটানিক্যাল গার্ডেন, ঢাকা).
2) 21 November 2014: Atkandi, Norshingdi (আটকান্দি, নরসিংদী).
3) 22 December 2014: Kukri-Mukri, Bhola (কুকরী-মুকরী, ভোলা).
4) 05 January 2015: Korapur, Barisal (কড়ারপুর, বরিশাল).
This article has written by Lonely Traveler,
for the blog http://icwow.blogspot.com/
শেষ বিকেলের পাখী, আমি যাযাবর...


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Reuters Staff
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