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ThemeForest Expression Photography Responsive WordPress Theme 2855595
ThemeForest Expression Photography Responsive WordPress Theme 2855595
WordPress Theme \ Creative \ Photography
Gallery \ Ajax \ Powerful \ Portfolio \ Photography \ Responsive \ Skins \ Wedding
WordPress Theme - Expression Photography Responsive WordPress Theme 2855595 by pexeto @ ThemeForest
WordPress Theme \ Creative \ Photography
Last Update: 19 December 12; Columns: 4+; Compatible Browsers: IE8, IE9, Firefox 2, Firefox 3, Firefox 4, Safari 4, Safari 5, Opera, Chrome; Software Version: WordPress 3.4; Documentation: Well Documented; High Resolution: No; Layout: Responsive; ThemeForest Files Included: Layered PSD, JPG Image, CSS Files, JS Files, PHP Files; Widget Ready: Yes.
- Version 1.2.1 – 19 December 2012.
- Fixed a small issue about the number of the images that is displayed on the item in the gallery not being correct when the images are not attachments of the portfolio item.
- Version 1.2.0 – 12 December 2012.
- Added support for the new WordPress 3.5 gallery management functionality to the grid gallery portfolio items. With this update the main way to add images to the items is by using the WordPress gallery functionality. You can read more about the changes in this article
- Added an option to load a Nivo slider within the content of a page/post by using a slider that is created from the Expression -> Nivo Slider section
- Social sharing in gallery sliders – when sharing an item, by default the featured image of the item is shared. With this update, if you don't set a featured image to the item, the first image of the default item image set will be shared
- Updated Timthumb to the latest version
- Updated the instructions in the documentation for the new WordPress 3.5
- Small code improvements
- Version 1.1.0 – 30 October 2012.
- Implemented descriptions for images in the fullscreen slideshow pages
- Child theme support: the initial release of the theme included child theme support for all the main styles and all the page templates. In this update we have also included child theme support for all the functions used in the theme.
- Implemented improvements into the PrettyPhoto lightbox plugin for mobile devices – now images are displayed to the full size of the screen on mobile devices.
- Added a 500px icon to the default icons set
- Added options to change the default texts in the contact form message
- Added featured image and description to pages when they are shared/liked on Facebook (before only posts and portfolio items had this functionality included)
- Code improvements and small issues fixes
Theme Details
Expression is a powerful responsive WordPress Theme, best suited for photographers and creatives who use portfolios to effectively present their work. Expression theme is powered by the advanced Pexeto Panel , which provides tons of options to manage and modify any aspect of the theme. With all the styling options provided you can easily customize the appearance of the theme and build you own custom skin .
Dynamic AJAX Gallery (unlimited pages)
Expression includes a flexible AJAX gallery with awesome jQuery animations and effects, which comes with lots of options available for its items.
For each gallery item you have the options to.
- dynamically open a fullscreen image slider (full-width or full-height) with a nice jQuery animation, containing lots of additional images attached to the item ( bulk upload – you can upload lots of images with a single click).
- open an image lightbox as image gallery attached to the item (images can be uploaded in bulk)
- play video in lightbox
- open item content in a new page
- open a custom link in a new page
Also there are lots of options the gallery provides, some of them are.
- Custom image sizes – the default image size can be changed on each gallery page. Also, for each image you can set the number of columns and rows to allocate, so you can have different layouts (landscape and portrait) and image sizes
- Unlimited gallery pages – you can create as many galleries as you need with different image sets
- Partial Loading in slider – loads images in background on portions for faster performance. Works well with big amount of images attached to a single item.
- Social Sharing – the fullscreen sliders in the gallery provide sharing options, so you can easily share your items images on the most popular social networks. By default buttons are included for Facebook, Twitter, Google+ and Pinterest, however there is also an option to include custom buttons code.
- Easy slider navigation – the gallery slider images can be browsed in different ways – mouse click, mouse scroll, keyboard and touch gestures.
- dynamic AJAX category filter (can be enabled/disabled per page)
Responsive Design
The theme is responsive, so that it fits and looks great on different size of devices – desktop, mobile phones and tablets. Also, the main gallery slider supports finger gestures, so it is very easy to navigate between the images on touch devices.
Unlimited Skins
The theme includes options to change all the main colors used – you can easily build your custom skin with your favorite colors. You can see some examples here .
Additionally, the theme comes with 34 different background patterns that you can choose from and if you would like to use your own custom background, the theme also provides an option to upload your own background pattern image or full width background image.
Font Management
The theme provides a friendly user interface to implement Cufon Font replacement and Google API Fonts . For the Cufon font replacement you can either use one of the fonts that the theme comes with or upload your own custom font . For the Google Fonts we have created a section where you can enable as many fonts as you like just by adding the URL the API provides. You can check out the font management section here
Retina Display Optimizations
We have included retina display optimizations for all the main graphics used in the theme. Also, the theme provides an option to set a custom logo image for retina displays.
3 Additional Sliders Included (unlimited usage)
Expression also includes three different sliders that can be included on separate pages – a Full-width slideshow page which displays the images in the full width of the window, a Full-height slideshow page which displays the images in the height of the window and a Nivo slider , which comes with lots of different animation effects and can be used in standard pages with additional content below.
Advanced Styling Buttons
The theme includes an unique set of buttons that allow you to directly insert the styled content into your editor area . In this way, you can easily organize your content while creating it without having to save and preview your page with every change you do.
Extensive Documentation
The theme comes with a detailed documentation , which includes examples, screenshots and all the main instructions you will need to customize your site. Additionally, we have included a "Beginners" section which includes some helpful links about working with WordPress and instructions about what steps to follow when setting the theme.
Other Key Features
- Post Formats Support, including the following formats.
- Standard Post – including a featured image in the header
- Video Post – including a video in the header
- Gallery Post – including a slider in the header
- Unlimited Sidebars – dynamic sidebar generation functionality
- SEO section included, allowing you to add key words, change title structure, exclude pages from indexation, etc.
- Easy page layout changing – for each page you can choose between.
- Right Sidebar
- Left Sidebar
- Full-width
- Easy theme translation – all the custom words used within the theme can be very easily changed from the admin panel. We have also included a .po file if additional languages will be used.
- Easy logo replacement with retina display support
- Separate portfolio section
- WordPress 3.0 Custom Menu Support
- jQuery Tabs
- AJAX contact form
- Sociable Icons section in header
- Comments with reply functionality (multiple levels depth)
- Multi level drop-down menu
- Lost of styled elements included
- PSD Files included
- A bonus widget included – Portfolio Posts Loader displaying the latest items in the sidebar
- Works and looks similar in all major browsers: Internet Exlorer, Firefox, Opera, Safari, Google Chrome
Thanks for the great resources to.
- Mono Social Icons http://icondock.com/free/mono-social-icons
- Pixel patterns http://naomiatkinsonproducts.com/
- Repeatable Pixel Patterns http://www.premiumpixels.com/20-repeatable-pixel-patterns/
- Tango icons: http://tango.freedesktop.org/Tango_Desktop_Project
- Vector Patterns http://speckyboy.com/2010/04/08/6-free-vector-seamless-backgrounds-source-files/
- Seamless Patterns http://www.premiumpixels.com/20-seamless-photoshop-grid-patterns/
Check out our other products.
Premium WordPress Themes
Expression Photography Responsive WordPress Theme; Photolux - Photography Portfolio WordPress Theme; The Cotton - Powerful Minimalistic WordPress Theme; Highlight - Powerful Premium WordPress Theme; Dandelion - Powerful Elegant WordPress Theme; Anthology - Premium Elegant WordPress Theme; Anthology - Elegant Premium HTML Site Template .
Keywords: advanced admin, ajax, ajax gallery, full screen slider, fullscreen, gallery, grid, masonry, modern, photography, portfolio, powerful, responsive, unlimited skins, wedding.
Premium ThemeForest Expression Photography Responsive WordPress Theme 2855595 WordPress Themes, Website Templates, Mobile Themes, Flash Templates & Scripts from creative professional designers. Full details of ThemeForest Expression Photography Responsive WordPress Theme 2855595 for digital design and education. ThemeForest Expression Photography Responsive WordPress Theme 2855595 desigen style information or anything related.
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New Delhi, Jan. 30: The railway is going mobile no pun intended.
Passengers will be able to buy tickets through mobile phones on the Net. The railway has been running a service since the latter half of last year for making bookings through the computer on the Net with the ticket being delivered at the address given by the passenger.
The service is available on www.irctc.co.in.
The expansion of communication aids and the extraordinary penetration of mobile phones in the common mans lifestyle cannot be ignored by the railway, railway minister Nitish Kumar said, presenting an interim budget today.
How to book a ticket'
You must have a mobile phone with Internet browsing facility. At the moment, there are seven million such subscribers.
Once you connect to the railway web page the site has not been created yet it will seek the passengers name, age, train, destination, date of journey and the address at which the ticket is to be delivered.
An SMS will be sent seeking payment through a credit card. Punch the credit card numbers and the confirmation will be instant. The ticket will be delivered at the destination. The service is expected to begin in a month.
For bookings through computers now, payment is also made by credit card at a service charge of 1.8 per cent plus Rs 50 for the delivery of the ticket.
There is a question in the minds of many about the security of credit card numbers. Possibly keeping that in view, the railway is starting a pilot project where payments can be made to the ticket inspector on the train.
Bookings will be made on the Net and passengers will be able to take a printout of the ticket from the computer itself. To begin with, the service will be available only for Shatabdi Express trains.
Cancellations, however, will be done only at public reservation system counters.
A payment option is under discussion with mobile phone service providers where the ticket price will be realised through the monthly bills of the subscriber. Sources in AirTel and Hutch confirmed that talks were under way.
Kumar also announced a scheme by which a passenger will get an SMS if a train is rescheduled by over 30 minutes. The service will be provided for the Rajdhani, Shatabdi and Jan Shatabdi trains to begin with.
The minister unveiled an incentive plan for regular travellers that is modelled on the frequent-flier scheme in airlines.
Frequent travellers on Rajdhani, Shatabdi and Jan Shatabdi trains in the First AC, Second AC and chair-car categories will get complimentary trips. The complimentary trip will be offered based on the number of journeys undertaken in one year by the passenger registered to avail of the benefit.
From July 1, all trains will have marshals to provide security to passengers who are often harassed by ticketless goons. The marshals will have the power to arrest and prosecute miscreants who commit minor offences.

subset: commoncrawl


text:
It looks like you are using an old version of your browser and some features of our website might not work properly.
For the best online experience, we recommend you update to the latest version.
From passionate foodies giving the best customer experience in our stores, to support roles that help our store teams right around the Australia, at Coles you can be the difference!
"The passion of our people inspires me every day - it's what makes my job meaningful: innovating how we work together to improve things for store teams and ultimately the customer."
Coles is one of the fastest growing retailers in the world. We're so passionate about customer that it affects every decision we make. I've brought together teams from across the business to challenge how we do retail; from the technology we use to the way we interact with each other and our customers. We get to see our ideas come to life and evolve through feedback from our team and customers.
Our Operations team manages over 2,200 sites across Australia, including supermarkets, liquor and convenience stores. We're all about the customer experience and creating an engaging store environment. The opportunities are endless; customer care, store management, innovation, area management, communications... Be a part of the story. You can make a difference to how millions of Australians shop, right here at Coles.
If you've decided that Coles is right for you and applied to a role, we'll be in touch soon. If you can't find a current role that's right for you, set up 'job mail' to hear all about new opportunities relevant for you – just search and click the link 'send me jobs like these'.


text:
Postcard + Garden = PostCarden/
Tomorrow is Earth Day! By now, you're familiar with all the important basics: always recycle, don't use plastic bags, and carry around a reusable water bottle. We know you're eco-savvy that way. So, let's skip Being Green 101 and get to something more fun...
The PostCarden ($13) is an amazingly designed postcard that pops up into an architectural structure. It comes with its own packet of seedlings that you sprinkle and water so that soon you will have your own miniature garden that can sit on your desk or window sill. You can grow a botanical garden, an urban landscape, or tend to your very own overgrown backyard.
There's nothing more green-friendly than growing something, so here's to the beginnings of all you budding botanists...via snail mail.
Watch this 30-second stop-motion video on how your Postcarden garden will grow!


text:
Roosevelt Auto Body Collision 1 University
Review for Roosevelt Auto Body Collision 1 University
Liliana S. on 07/15/2013
Liliana said the business did not perform any paint work, they only replaced her mirror. She said the business is friendly and they did not try to overcharge her.
Category: Collision
Service Date: 07/01/2013
Review Created: 07/15/2013
This review was collected via phone interview by Customer Research Inc.


text: Video News: United Kingdom Tough talking in Greece as police brace for demos The serious talking has got underway in the Greek parliament and the protesters are back. Riot police are on high alert outside the building as thousands gathered to demonstrate against the vote on austerity measures. More than three billion euros of cuts is the price of a 130-billion-euro rescue package. ...http://www.euronews.net/Auteur: euronews-enTags: Tough for euronews talking Demonstration demos Greece police brace Gepost: 12 februari 2012Beoordeling: 0.0Stemmen: 0]]> © DailyMotion - Sunday, February 12, 2012


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The present study was conducted to examine cytokine profiles in the masseter muscle before and after complete Freund's adjuvant (CFA)-induced inflammation and possible sex differences in the cytokine levels. Age matched male and female Sprague Dawley rats were injected with CFA in the mid-region of the masseter muscle. Muscle tissue surrounding the injection site was extracted 6 hrs, 1, 3 and 7 days after the injection to measure TNF-α, IL-1β, IL-6 and IL-4 levels with Luminex multi-analyte profiling (xMAP) technology. The cytokine levels were compared to those obtained from naïve rats. CFA injection into the masseter muscle led to a significant time effect in the level of TNF-α compared to that of naive rats. The pattern of changes in TNF-α level after CFA injection was significantly different between the male and female rats owing to the differences in basal levels. CFA injection induced significant time-dependent increases in the levels of IL-1β and IL-6 in the masseter muscle in both male and female rats. The level of IL-4 was slightly, but significantly, reduced in both sexes at 6 hrs and 3 days after CFA-induced inflammation. No significant sex differences were observed in the levels of IL-1β, IL-6 or IL-4. The results provided novel information about distinct cytokine profiles during CFA-induced muscle inflammation, and the basis for further pursuing contributions of each cytokine in pain processing and analgesic responses in both sexes.
Musculoskeletal pain conditions including neck pain, back pain, orofacial muscle pain and other chronic widespread pain conditions such as fibromyalgia are prevalent and severe pain conditions. While most of our knowledge about chronic types of pain is based on cutaneous pain models, muscle pain conditions, including exercise-induced muscle pain and orofacial muscle pain related to temporomandibular disorders, appear to utilize different mechanisms in the development and maintenance compared to cutaneous pain [21,34].
Many chronic musculoskeletal pain conditions have been shown to originate from muscle inflammation [1,15,20,22]. Cytokines released locally during inflammation modulate nociceptive processing via multiple mechanisms. Cytokines can directly sensitize nociceptors and increase neuronal sensitivity to heat, mechanical and chemical stimuli [17,18,24,26,35]. Inflammatory cytokines, such as interleukin (IL)-1β and tumor necrosis factor (TNF)-α, contribute to pain and hyperalgesia indirectly by inducing the production of inflammatory agents that sensitize nociceptors [2,28]. In addition, inflammatory cytokines are powerful modulators of the expression of many receptors involved in pain and analgesia. For example, TNF-α significantly up-regulates TRPV1 in trigeminal sensory neurons [19]. In the opioid system, IL-1β, IL-6, TNF-α and IL-4 induce mu-opioid receptor expression in neuronal and non-neuronal cells [3,4, 30]. Similarly, in the cannabinoid system, cytokine-stimulated whole blood elevates CB1 and CB2 mRNA and protein levels when compared to non-stimulated blood [16]. Thus, changes in cytokine profiles in the local tissue during injury or inflammation can provide potent modulation of nociceptive signaling processes.
Studies based on cutaneous tissue have demonstrated distinct changes in cytokine profiles after inflammation and tissue injury: e.g., tissue injury induces bradykinin release leading to the release of TNF-α, which results in the release of IL-6 and IL-1β [28]. There are, however, distinct differences in carrageenan-induced changes in cytokine profiles when cutaneous hindpaw tissue is compared to gastrocnemius muscle in female Sprague Dawley rats [20]. TNF-α is elevated significantly in the hindpaw but not in the muscle. Both IL-1β and IL-6 are elevated at an earlier time point in the cutaneous hindpaw tissue compared to the muscle tissue. These data confirm that there is a specific cytokine profile associated with muscle inflammation, at least in the female rats.
However, since pain responses from males and females vary a great deal in many chronic musculoskeletal pain conditions, and the two sexes also respond differently to inflammation [11], it is important to examine whether there are sex differences in the cytokine profiles in muscle under inflammatory conditions. At present, there is no study that has directly assessed potential sex differences in the local cytokine levels under inflammatory conditions. Thus, the objective of this project was to establish the cytokine profiles in the masseter muscle before and after complete Freund's adjuvant (CFA)-induced inflammation in both male and female rats. We chose to analyze the levels of three pro-inflammatory cytokines TNF-α, IL-1β, IL-6 and one anti-inflammatory cytokine IL-4 because of their known roles in inflammation and as modulators of receptor expression and nociceptive signaling at the primary afferent level.
Age matched adult male and female Sprague-Dawley rats (8 weeks old; 250–300g for males and 225–260g for females) were used in this experiment. All procedures were conducted in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals. The levels of cytokines in the masseter muscle were analyzed in naïve rats, and rats treated with CFA at 6 hrs, 1, 3 and 7 days following the CFA treatment. All groups, except for the 6 hr time point, consisted of 6 rats. The 6 hr group consisted of 4 rats. CFA (Sigma; 1:1 in isotonic saline; 50μl) was injected directly in the mid-region of masseter muscle to induce local inflammation. In additional groups of naïve and CFA-inflamed rats (1 day post CFA) plasma samples were collected by cardiac puncture to assess whether the changes cytokine levels in the muscle result from local inflammatory response or systemic reaction. Estrus cycle in female rats was not determined in this study.
All animals were euthanized by decapitation under pentobarbital anesthesia (100mg/kg). Masseter muscle surrounding the injection site (approximately 100mg) was extracted and homogenized in RIPA buffer (Cell Signaling Technology, Inc., Danvers, MA) containing complete protease inhibitor cocktail tablets (Roche Diagnostics, Berkeley, CA). The amount of RIPA buffer added was nine times the weight of the tissue sample. The total protein concentration in lysate was determined using the Bio-Rad protein assay kit (Bio-Rad, Hercules, CA) and the amount of protein was normalized to that of the control sample. Total protein of 2mg (250μl, 8μg/μl) was used in the cytokine assay for each sample.
The Luminex multi-analyte profiling (xMAP) technology (Luminex corp.) was used to measure cytokine levels. Bead sets were coated with capture antibody for various cytokines (TNF-α, IL-1β, IL-4 and IL-6). Fluorescence detection antibodies were then applied to bind the cytokine-capture antibody complex on the bead set. Multiple cytokines in the samples were then recognized by the differences in bead sets with fluoregenic emission detection using flow cytometric analysis [29]. Each sample was measured in triplicate. Two-Way ANOVA was used to compare the cytokine levels between naïve and CFA groups and between male and female rats. All comparisons between multiple groups were followed by a post hoc test (Bonferroni). Data are presented as mean ± SEM and differences were considered significant at p<0.05.
In male rats, the mean level of TNF-α in the masseter muscle was at its highest (90.1±46.7 pg/ml) under the naïve condition (Fig 1A). The injection of CFA into the masseter muscle induced a gradual decrease in the TNF-α level. The mean TNF-α level was reduced to 86.9±23.3, 40.4±15.4, 24.7±7.6, and 13.3±3.4 pg/ml after 6 hrs, 1, 3 and 7 days, respectively. In female rats, the mean level of TNF-α in the masseter muscle was 6.4±0.65 pg/ml under the naïve condition, about 14 fold less than the level in naïve male rats. However, after CFA injection, the level of TNF-α in female rats increased to 36.6±10.2 pg/ml after six hours and 49.7±13.5 pg/ml after one day before returning to the level under the naïve condition after three days. Significant sex differences between male and female rats were observed due to the low basal level in female rats (F=6.417, p=0.015). There was also a significant time effect on inflammation-induced TNF-α levels (F=2.767, p=0.038), but post hoc analysis did not detect significant group differences. A significant group difference was found only between naïve and CFA 7day male rats. No other individual group comparisons were significant.
The mean level of IL-4 decreased slightly but significantly after the CFA injection (F=4.065, p=0.007) (Fig 1B). Under the naïve condition, the mean levels of IL-4 were 64.7±11.5 and 61.8±14.7 pg/ml for male and female, respectively. Six hours after the CFA injection, the mean levels of IL-4 decreased significantly to 27.0±4.5 and 26.5±4.4 pg/ml in male and female respectively. A second phase of slight decrease in the IL-4 level was observed three days after CFA injection. No significant sex difference was detected (F=0.138, p=0.712).
The mean levels of IL-1β in the masseter muscle were low in both male (9.3±4.9 pg/ml) and female rats (1.0±0.5 pg/ml) under the naïve condition (Fig 2A). Injection of CFA into the masseter muscle induced a substantial increase in the IL-1β levels in both sexes (~1000 pg/ml) as early 6hrs and remained significantly increased for one day (F=43.258, p=<0.001). Seven days after CFA injection, the levels of IL-1β in both male and female rats decreased to approximately 100 pg/ml. No significant difference in the IL-1β level was detected between naïve and CFA 3 or 7 day groups. There appeared to be a slight delay in the increase and decrease in the level of IL-1β in females compared to males; however no significant sex difference was observed (F=0.548, p=0.463).
The pattern of inflammation-induced changes in the level of IL-6 was similar to that of IL-1β. The mean level of IL-6 was 29.6±13.3 pg/ml in both male and female rats under the naïve condition (Fig 2B). Injection of CFA into the masseter muscle induced a significant and substantial increase in IL-6 levels in both sexes (F=79.190, p<0.001). Six hours after the CFA injection, the level of IL-6 rose to approximately 10,000 pg/ml, more than a 300 fold increase from the naïve condition. The mean level of IL-6 remained significantly increased after one day, which then gradually decreased to approximately 200 pg/ml after 7 days. There were no significant differences in the IL-6 level between naïve and CFA 3 or CFA 7 day groups. No significant sex difference was detected (F=0.940, p=0.337).
In order to rule out the possibility that the CFA-induced changes in cytokine levels in local tissue did not result from systemic reactions the plasma levels of all 4 cytokines collected 1 day after CFA inflammation were compared to those of naïve rats. The plasma levels of TNF-α, IL-1β, and IL-4 were below the detection level in both naïve and CFA treated rats. The plasma level of IL-6 was detectable but there was no significant difference between naïve and CFA treated rats (t=1.127, p>0.05).
Since we used naïve rats rather than vehicle injected rats as the control group we conducted additional experiments to assess whether the vehicle injection significantly alters the local cytokine levels compared to those of naïve rats. The data showed that the vehicle injection did not significantly alter the local levels of TNF–α (t=1.28, p=0.24), IL-6 (t=0.01, p=0.99) and IL-4 (t=2.1, p=0.07). There was a statistically significant difference in the levels of L-1β between naïve and vehicle treated rats (t=3.31, p=0.03). However, the range of IL-1β levels in naïve and vehicle treated groups were comparable (0–30 pg/ml and 17–40 pg/ml, respectively), suggesting that the surge of IL-1β in orders of magnitude following CFA injection is not due to the injection procedure, but to local inflammatory responses.
Few studies have directly compared cytokine levels between males and females. A significantly higher plasma IL-1β level in male patients compared to females was reported following abdominal trauma [8]. A greater concentration of serum IL-6 in men has been implicated in hepatocellular carcinoma, the most common liver cancer in men, while estrogen-mediated inhibition of IL-6 reduces the risk of liver cancer in women [23]. The present study provides the first report regarding sex-based observations on local cytokine profiles following muscle inflammation. Our data showed that CFA-induced inflammation produced similar changes in IL-1β, IL-4 and IL-6 levels between the male and female rats. Inflammation differentially impacted the levels of TNF-α between the sexes, which may result from the difference in the basal levels of TNF-α in the masseter muscle in male and female rats.
In contrast to cutaneous tissue, the level of TNF-α in gastrocnemius muscle does not increase in female rats after carrageenan-induced inflammation [20]. Our data showed that the level of TNF-α in the masseter muscle decreased significantly only at a later stage of CFA-induced inflammation in male rats. However, the level of TNF-α in the masseter muscle in female rats rose slightly at 6 hrs and 1 day, owing to the low basal level. The differences in the basal levels and the pattern of inflammation-induced changes in TNF-α levels in female rats between this study and that of Loram et al [20] could be attributed to the types of muscle (limb vs. craniofacial) or the inflammatory agent (carrageenan vs. CFA). There was large variability in TNF-α level in the masseter under naïve conditions in male rats. We do not know the source of the variability at this point, but it is possible that TNF-α level in local tissue in intact animals may not be stable compared to other cytokines.
The increase in the level of TNF-α during CFA-induced inflammation in female rats was only modest compared to that of IL-1β or IL-6. Also, the level of TNF-α following CFA injection was comparable between male and female rats. These observations suggest that muscle inflammation does not significantly impact the levels of TNF-α. Direct intramuscular injection of a high dose of TNF-α produces mechanical hyperalgesia [32], and sensitizes trigeminal muscle afferents in male rats [12]. The same concentration of exogenous TNF-α could produce different responses in female rats since the basal level is substantially lower in the masseter muscle of female rats. Thus, the contribution of TNF-α at a physiological concentration in muscle pain processing and potential sex specific responses remains to be determined.
IL-1β mediates inflammatory pain and hyperalgesia by inducing a widespread expression of prostanoids both in the periphery and in the CNS [9,31]. In the muscle tissue, IL-1β regulates IL-6 production, which may be involved in muscle injury, degeneration and repair of the muscle [14]. The level of IL-1β increases in human skeletal muscle after eccentric exercise for a prolonged period of time and has also been shown to be a potent hyperalgesic agent [5,9,10]. Similarly, the concentration of IL-1β is elevated in the trapezius muscle of human patients with active myofascial trigger points [34]. In an animal model of muscular hyperalgesia, the surge of IL-1β in the gastrocnemius muscle during carrageenan-induced inflammation occurred at 24 hrs. This followed the initiation of primary muscle hyperalgesia occurring as early as 3 hrs post injection. These observations led the authors to suggest its role in the maintenance of hyperalgesia in muscle tissue [20]. However, carageenan injected in the rat masseter muscle causes an immediate increase (i.e. 1 hr post injection) in the level of IL-1β [27]. In the present study, we also showed a prominent increase in masseteric IL-1β levels following CFA-induced inflammation in both male and female rats. The increase in the levels of IL-1β could be observed from 6 hrs and were maintained until the 3 day time point. Again, the differences could be due to the more potent and prolonged effects of CFA compared to carageenan as well as tissue specific responses.
CFA injected in the rat masseter muscle and the hindpaw have been shown to significantly up-regulate mu and kappa opioid receptors, respectively, in sensory neurons [25,29]. Interestingly, a local injection of IL-1β also significantly up-regulates kappa opioid receptors and treatment with an IL-1 receptor antagonist blocks the CFA-induced up-regulation of kappa opioid receptor expression in sensory neurons, and thereby increasing kappa mediated analgesia in the periphery [29]. Taken together, these data suggest that the surge of IL-1β in local tissue following inflammation contributes to pain and hyperalgesia, as well as analgesia. However, a potential role of IL-1β in mediating sex differences in pain and analgesia may not be explained solely by the local level of IL-1β.
While there is no clear consensus on the role of IL-6 in inflammatory muscle pain, it is likely that IL-6 is involved in multiple aspects of skeletal muscle physiology and pathophysiology. IL-6 is markedly increased during eccentric and concentric contraction of the muscle and involved in protein degradation during muscle damage as well as during muscle regeneration [6,36–38]. Acute injections with IL-6 in the gastrocnemius muscle do not excite or sensitize muscle nocieptors in anesthetized rats [14]. However, local IL-6 injections not only produce muscular hyperalgesia that lasts for several hours but also play a key role in the development of chronic latent hyperalgesia [7]. An immediate rise of intramuscular IL-6 mRNA expression following electrically-induced muscle contraction and carrageenan–induced inflammation in the masseter muscle suggests a multifunctional role for IL-6 across different types of muscle tissue [27]. In addition, our data showing that IL-6 in the masseter muscle increased significantly and dramatically (more than 300 fold) in both male and female rats after CFA-induced inflammation further support the contribution of IL-6 in muscle pain and metabolism in both sexes.
The anti-inflammatory and anti-hyperalgesic effects of IL-4 have been demonstrated [13,40]. However, the information on inflammation-induced changes in IL-4 in the muscle tissue and potential sex differences in its level is not available. In this study, we showed that the levels of IL-4 in the masseter muscle were reduced slightly but significantly in both sexes at the 6 hr and 3 day time points, indicating a pro-inflammatory effect at those time points. It is possible that the reduced level of IL-4 contributed, at least partly, to the increase in IL-1β and IL-6 [39]. IL-4 also contributes to anti-hyperalgesic effects by up-regulating peripheral opioid receptors under inflammatory conditions [4]. Because similar changes were observed in the levels of IL-4 in both sexes, IL-4 mediated anti-hyperalgesic effects are not expected to exhibit sex differences. Since we did not assess the estrus stages for the female rats the potential influence of circulating estrogen on local cytokine profiles cannot be determined in this study. Additional studies with female rats in different estrus stages or with ovariectomized rats should provide more precise information about the role of estrogen in local cytokine responses.
In summary, this study established the cytokine profiles in the masseter muscle before and after CFA-induced inflammation. These observations provided the basis for the potential contribution of each cytokine in inflammation-induced pain and analgesic responses in the muscle tissue in both sexes.
We thank Jami L. Saloman for helpful comments during the manuscript preparation. This work was supported by NIH-NIDCR grant DE019448 to JYR.
Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Complaint Review: All Animal Veterinary Center Aka Dr. Jan Elise Cerro
- All Animal Veterinary Center Aka Dr. Jan Elise Cerro
18201 Honor Hwy
Interlochen, Michigan
- Phone: 231-275-5772
- Web:
- Category: Veterinarian Services
All Animal Veterinary Center Aka Dr. Jan Elise Cerro horrible employer, very impersonable with clients, sells outdated pet food or gives it to pets in boarding RIPOFF Interlochen Michigan, Internet
*General Comment: All Animal Veterinary Center
*Consumer Comment: "Life is [not] a Bowl of Cherries"
I was asked to work on Tuesday and Thursday afternoons and on the weekends. On the two weekdays that I would work I would do janitorial duties for the most part and sometimes I would get to help out or watch what was going on in the hospital. On the weekends my main priority was to take care of the animals in boarding. I would also have other chores along the janitorial aspect to do. Janitorial work was not what I wanted to do but I thought it was a good way to be introduced to the veterinary hospital scene.
I was at that time attending a college that was about ten miles from the hospital. I was twenty years old and giving up my weekends to work at this hospital. I was not real happy with doing that but I needed the money and I got to spend time with animals and learn some.
In September I moved out the dorms at the school and moved in with my fiance. Now the distance to work had increased to twenty miles. Shortly after we adopted a six-month-old Australian Shepard from the Humane Society, named Ella.
Dr. Cerro told me that I could bring Ella with me to work to get her some socialization. I thought this was great until Dr. Cerro would start to tell me how I should train my dog. I understood that she probably knew what she was talking about but if I had any questions on training my dog I would have asked. Clients would make similar statements about Dr. Cerro.
One day Ella escaped into the reception area and Dr. Cerro tried to grab her collar to bring her into the back and Ella snapped at her. Of course I was told what I should do about that and told that I should get Ella into some obedience classes. That same day as Dr. Cerro was letting the other dogs out she tried to get Ella to go out with them. Ella did not want to listen to her and I could not go to let her out at that time because I was busy doing some work. Dr. Cerro grabbed Ella by the collar and drug her to and out the door.
Needless to say I was a little pissed off at that point in time. I decided that I would not bring Ella with me to work unless absolutely necessary.
I had to work on holidays too and on Christmas morning I rolled my fianc's jeep. I was in the hospital until eight pm. This was when I decided that maybe driving so far was not such a good idea if my life was in danger because of the weather and roads.
I planned on transferring in January, to the college that the vet technician was attending. I talked to Dr. Cerro about not being able to continue working there because of so much driving for school then. I had to drive fifty-two miles one way to school twice a week and if I were to continue working during the week (forty miles a day twice a week) and on the weekends (forty miles a day, twice a day, on Sat. and Sun.) that adds up to about 450 miles a week.
Dr. Cerro told me that she would give me a $0.50 raise and that I could work all day (8am to 5pm) on Saturdays and Sundays and not work on the weekdays anymore. I told her of the possibility of having to find a secondary job to keep up with my car payments. She told me there would be no need for that and that she was sure that what I would be working would be enough for the $230 payments each month.
I started classes in the beginning of January and by the end of the month I realized that my measly paychecks of about $150 every two weeks was not going to be enough to pay my car payment and pay for gas to do all the traveling I needed to do. I then got a job at the new movie rental place that was only seven miles from my house and on the way to school.
My second job was very flexible to work around my classes and my job at All Animal Veterinary Center. This way I did not have to tell Dr. Cerro because neither job conflicted with the other.
Over the next month and a half I struggled to work two part time jobs, go to school, plan my wedding that was coming up on March 17 and put up with Dr. Cerro telling me everything I did was done the wrong way or not done good enough. She continually tried to use intimidation as authority. I recognized this and did not let it get to me.
In February the hospital had a rabies clinic on a Saturday morning. I was previously told about it and was told that they may need me to help that day. I got there a little late; it's hard getting up early all the time. I had a bunch of jokes and short stories to do with animals and vet offices that I wanted to ask Dr. Cerro if she wanted to put them up somewhere for clients to enjoy while waiting. She would not let me get one word out and started in on me that I was late and that I had to have all the boarding animals done by nine (that was when the rabies clinic started). I understand that she was upset that I was late on a busy day (I was only 15 minutes late).
I let it go and went to deal with the five or six dogs that were in boarding. As I was outside with one of the dogs Shelly Desmond, the groomer, came in and told me that if I had any problems with one of the dogs that I could come and ask her for help getting that particular dog inside. I did have problems getting that particular dog inside. For about 15 minutes I tried to get this one dog inside. I went and asked Shelly if she could help me and she very rudely told me that she was busy and that I would have to do it myself.
I was done just after nine only because I had trouble with the one dog. Regardless of the rude behavior towards me that morning I went out to the reception area and asked Shelly if there was anything I could help her with. I helped her catch up on the new client forms and then went and asked the vet technician and Dr. Cerro if there was anything they needed help with, they told me no and to see if Shelly needed help. I told them that I already had but that I would check again. I was in the reception area for about two minutes and Dr. Cerro came out and said to me, "You can clock out now!"
In a not-so-good mood I left and did not return until 5 pm when I was to be there for my evening shift. There was a huge list of things that she wanted me to do. One of the first things that was on the list was that I could not work more than 3 hours per shift. I did not understand where this came from or why.
On the list of things she had estimated times that it should take to do them. These estimated times added up to 3.5 hours not 3. I pointed this out to her and told her that the reception floor could use a second vacuuming and mopping but that the time allotted to me to work did not allow me to do so. I formulated a template worksheet for the weekends and used those to show her everything I did from the time I arrived to the time I left.
Dr. Cerro showed up Saturday evening and started bitching at me about being late and that I was just getting in the way at the rabies clinic. She also told me that I had poor efficiency, poor reliability, and poor organization. One of the last things she told me was that I was "not going to move up in the world" with out those things and that no one was going to let me move up in the world. I just listened and walked away so as to not lose my job because of the things I wanted to say.
Back in December I had asked Dr. Cerro for the weekend of March 18 and 19 off because I was getting married and my parents were coming down for it and I wanted to spend time with them. This was about a three-month notice to get someone to work that weekend.
The beginning of the month I was asked to organize the storage room (kind of ironic, huh?) and in doing so I found out dated pet food on the shelves. I brought this to Dr. Cerro's attention and she said that she would talk to the vet technician about it and to pull the outdated stuff off the shelves and that it would get dealt with. The following weekend I noticed the food I had pulled off the shelves was mixed in with the food for the animals that were in the hospital and put into the food for the animals that were in boarding. That is absolutely disgusting! I was outraged but did not know what to do from there.
The week of March 14 through the 18 was also finals week at school. I only had classes on Mondays and Wednesdays; those were the only two days I had to be at class. The weekend prior to finals week Dr. Cerro did not have much extra for me to do and I thought that was great and that I would have more time to study.
I did what was on the "to do list" on Saturday. I found the mop bucket full of dirty water for about the millionth time. I wrote a polite note saying, "To Whom it May Concern, I found the mop bucket full of dirty water again. It would be much appreciated if the water was emptied after it is done being used." and I signed it. On Sunday when I went in I found that Dr. Cerro put a big red x over my note and wrote, "(Name), this will not happen! The mop bucket is left to be used at the last minute of the day. The person who finds it the next day is to empty it! The important this is that the mop is not left in the water. DOC" She also added more things to the "to do list."
I was very upset. She knew that I had finals to study for; her own vet technician had finals at the same time because we were going to the same school. She also knew that my parents were coming down and that I was getting married. I did not feel that I had to put up with any more the stuff I had been putting up with. On that Sunday evening I wrote a short note saying, "Dr. Cerro, I regret to inform you that I am giving you my two weeks' notice. I will send you a more formal resignation letter as soon as I can write one." and signed my name to it.
Monday morning Dr. Cerro called my house looking for me and did not leave a message. The instant she hung up she called my cell phone and finally left a message. The only reason I know that the two phone calls were one right after the other is because of the caller I.D. The message she left on my cell phone was to give her a call as soon as I got the message. I received the message on my break during one of my classes. I did not have time to call her back at that point in time.
I got home after 7pm, took a shower, had dinner and worked on my ten-page research paper that was due on Wednesday. On Tuesday I continued to work on my papers and other homework for school and then Wednesday I went to classes and had my finals. Wednesday my parents were also on their way down from ten hours away. When I got home my fiance had left a note telling me that Dr. Cerro had called and said that boarding for the weekend had been taken care of and that I was to give her a call.
My fiance was not home because he and my dad went to Ann Arbor to pick up his cousin who was to be in our wedding the next day. My family and friends were staying at our house so I had to attend to them and make sure they had places to sleep and also had to show my mom where the store was to get food for that night. I had absolutely no time to even call my parents on Tuesday to give them directions to our house, my fiance had to do that.
Thursday was the wedding and that day was horribly hectic. On Friday the friends and family I had at our house wanted to go shopping at the mall in Traverse City. I thought that because we were going to go right past it that I could stop at the animal hospital to get my check.
The hospital does not close until 5:30pm. We arrived at 5pm and the new receptionist (the previous one was also resigning for similar reasons as mine) was leaving. I was confused as to why she was leaving early and I just figured that I had the key so I could still go in and get my check. I went in and tried to put in my alarm code and the alarm still said armed I tried two or three more times and it did not work. Wonderful, that meant that she took my code off the alarm. I went to see if my check was where it was supposed to be and it was not. I left the building and called Dr. Cerro.
She again would not let me say much and that she would be there shortly to turn the alarm off. I then asked, "Well, then where is my check?" she said that it was locked up until she got my key. So I was getting fired for quitting. My mom accompanied me inside to give her the key and get my check. I started to apologize that I had not gotten a chance to call her because of being so busy. She cut me off and told me that she had called me twice with no response and that she would accompany me out the back door and that she did not want to speak to me.
I again tried to tell her why I hadn't gotten a chance to call her and that I had finals. She just repeated the same thing she said before. So my mom said, "It's not worth it. Let's go." and we left.
Today, 3/23/05,I received a certified letter stating that they "no longer required my services" but that I could still bring my animals in as a regular client. I could not believe she has the audacity to tell me to keep brining my animals there after she would not even let me speak to her.
Last week I was talking to a co-worker of mine at the movie rental store and she told me that she had brought her dog to the All Animal Veterinary Center and that she would never bring him there again because of the way Dr. Cerro handled her dog and that Dr. Cerro had tried to tell her how to train her dog just because he was fussing about being handled by her. No animal really likes to go to the vet so of course they are going to fuss about being handled by him or her.
I am now done working there and will be sending her a letter including this report.
Frankfort, Michigan
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This report was posted on Ripoff Report on 03/23/2005 01:51 PM and is a permanent record located here: http://www.ripoffreport.com/reports/all-animal-veterinary-center-aka-dr-jan-elise-cerro/interlochen-michigan-49643/all-animal-veterinary-center-aka-dr-jan-elise-cerro-horrible-employer-very-impersonable-136150. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year. Ripoff Report has an exclusive license to this report. It may not be copied without the written permission of Ripoff Report. READ: Foreign websites steal our content
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#1 General Comment
All Animal Veterinary Center
AUTHOR: Lew - (United States of America)
SUBMITTED: Wednesday, January 26, 2011POSTED: Wednesday, January 26, 2011
Regarding your comments. Sounds to me like a spoiled little girl that didn't get her way and has decided to use this form and the internet to slander Dr. Cerro.
Shame on Ripoff Report and the Reputation Repair folks for posting this information.
#2 Consumer Comment
"Life is [not] a Bowl of Cherries"
SUBMITTED: Wednesday, May 11, 2005POSTED: Wednesday, May 11, 2005
Maybe I can save you a little heartache and frustration as you progress through life and possibly mature in the process.
What a myriad of detailed excuses you have presented as to why you were apparently unable or unwilling to perform your assigned job duties to this employer's satisfaction.
Many employers who hire part-time college or high school students do attempt to accommodate their individual class schedules however you seem to believe you were entitled to special treatment because of the circumstances in your personal life.
It appears that you not only attempted to determine what your job duties should be but resented any instruction or direction from the person paying your salary (described by you as "bitching").
You stated "[s]he also told me that I had poor efficiency, poor reliability, and poor organization. One of the last things she told me was that I was "not going to move up in the world" with out those things and that no one was going to let me move up in the world. I just listened and walked away so as to not lose my job because of the things I wanted to say." This could have been construed by you as constructive criticism. An appropriate response would have been to ask for specific suggestions as to how you could improve your job performance to your employer's satisfaction.
As to your comment, "[I] got there a little late; it's hard getting up early all the time," you will find this excuse will be unacceptable to most employers. You will be expected to make every effort to be punctual, compliant, and willing to perform the job duties assigned to you.
How was the veterinarian "very impersonable with clients?" Granted, she should not have provided "outdated pet food" to her patients and you correctly brought this to her attention. If she continued to dispense such foodstuffs to unsuspecting clients, it would have been appropriate to report this to the proper overseeing agency in your state. It is not too late to do this.
As for co-workers being "rude" - this is a fact of life. You will deal closely with all types of people in future work settings with whom you would not choose to be associated.
Please adjust your attitude. Your complaints sound so petty. The world is not going to change for you.
By the way, in reference to your comment "Last week I was talking to a co-worker of mine at the movie rental store and she told me that she had brought her dog to the All Animal Veterinary Center and that she would never bring him there again because of the way Dr. Cerro handled her dog and that Dr. Cerro had tried to tell her how to train her dog just because he was fussing about being handled by her. No animal really likes to go to the vet so of course they are going to fuss about being handled by him or her.":
Most pet owners would appreciate and not resent being advised by a professional as to how to train a recalcitrant pet who behaves aggressively or threatening while in a veterinary setting. If the veterinarian was actually mistreating or mishandling the dog, this would be a different story. My dog doesn't particularly enjoy visiting her veterinarian, however, she is always well-behaved and congenial, and as a result is a favorite of the employees in the veterinary hospital. Her doctor is thus able to gently and thoroughly perform her examination without fear of being bitten or mauled and as a result the dog relaxes as well.
Good luck in your future endeavors.
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Question: When is LevelUp?
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GraphicRiver Fitness Club Trifold Brochure Template 10611887
Category: Print Template | Comment: ( 0 )
GraphicRiver Fitness Club Trifold Brochure Template 10611887
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Tri-Fold Brochure Template is 8.5 by 11 in (8.75 in by 11.25 in with bleeds) and is ready for print, because it's in CMYK at 300 dpi. The psd file can be edited in Photoshop, and to be simple able to change the text.
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The Feist-Weiller Cancer Center (FWCC) Minority-Based Community Clinical Oncology Program (MB-CCOP) aims to provide increased access to state-of-the-art cancer prevention care, and control through NCI-sponsored clinical trials to the minority and indigent populations in the northwestern section of La., and throughout the state of Louisiana. The Feist-Weiller Cancer Center was established at the Louisiana State University Health Science Center in Shreveport (LSUHSC-S) to provide multidisciplinary cancer care, and clinical and translational research targeted to the unique population in Northwest La, which will improve the public health by decreasing cancer incidence and deaths. The population was plagued with high rates of poverty, low literacy and low levels of education, little access to modern approaches to prevention, detection, and treatment of cancer, and often presented with late stages of cancer, Fifty-five percent of newly diagnosed cancer patients at LSUHSC-S are African-Americans, With the destruction of Charity and University Hospitals in New Orleans by hurricane Katrina, LSUHSCS is now the only intact tertiary care hospital providing care to the state's indigent population and has become the major site for treatment of patients with leukemia and lymphoma, and those requiring bone marrow transplant. To provide local access to cancer clinical trials for the increased referral area, the FWCC will continue to strengthen and expand its organizational and operational base in order to support a structure to effectively implement a program to provide a multidisciplinary approach to cancer care and prevention for patients referred to the FWCC and in the patients'local communities. The FWCC MB-CCOP has provided access to NCI-sponsored clinical trials and research coordinator support at outlying sites. Education will be provided to community physicians through teleconferencing cancer tumor boards. Outreach programs to educate the indigent and minority population about cancer prevention, screening, and treatment, and clinical trials available through the FWCC MB-CCOP will be conducted with the assistance of the Louisiana Cancer Control Partnership, an organization dedicated to reducing cancer disparities by providing education, screening, referrals, information dissemination, and other resources in the minority and underserved communities. As well, the FWCC Partners in Wellness Free cancer screening program will be utilized to spread this valuable educational information. Since the FWCC has been founded, our approach to cancer has resulted in outcomes at LSUHSC-S at least as good as the national average and far better than Louisiana as a whole which ranks 49th in cancer mortality. The FWCC has a history of greater than 40% minority accrual to SWOG, CTSU, and NCI treatment and prevention studies, as well as industry, in-house, and translational research protocols. Plans to expand minority access and accrual are detailed in this application.
The provision of a multidisciplinary cancer care program to a population plagued by poverty, illiteracy, and little access to innovative approaches to the prevention, detection and treatment of cancer will serve to educate and treat this population, thereby decreasing cancer incidence and deaths.
|Othus, Megan; Appelbaum, Frederick R; Petersdorf, Stephen H et al. (2015) Fate of patients with newly diagnosed acute myeloid leukemia who fail primary induction therapy. Biol Blood Marrow Transplant 21:559-64
|Budd, George T; Barlow, William E; Moore, Halle C F et al. (2015) SWOG S0221: a phase III trial comparing chemotherapy schedules in high-risk early-stage breast cancer. J Clin Oncol 33:58-64
|Barr, Paul M; Li, Hongli; Spier, Catherine et al. (2015) Phase II Intergroup Trial of Alisertib in Relapsed and Refractory Peripheral T-Cell Lymphoma and Transformed Mycosis Fungoides: SWOG 1108. J Clin Oncol 33:2399-404
|Goldkorn, Amir; Ely, Benjamin; Tangen, Catherine M et al. (2015) Circulating tumor cell telomerase activity as a prognostic marker for overall survival in SWOG 0421: a phase III metastatic castration resistant prostate cancer trial. Int J Cancer 136:1856-62
|Lee, Sylvia M; Moon, James; Redman, Bruce G et al. (2015) Phase 2 study of RO4929097, a gamma-secretase inhibitor, in metastatic melanoma: SWOG 0933. Cancer 121:432-40
|Yao, S; Sucheston, L E; Zhao, H et al. (2014) Germline genetic variants in ABCB1, ABCC1 and ALDH1A1, and risk of hematological and gastrointestinal toxicities in a SWOG Phase III trial S0221 for breast cancer. Pharmacogenomics J 14:241-7
|Advani, Anjali S; McDonough, Shannon; Copelan, Edward et al. (2014) SWOG0919: a Phase 2 study of idarubicin and cytarabine in combination with pravastatin for relapsed acute myeloid leukaemia. Br J Haematol 167:233-7
|Philip, Philip A; Goldman, Bryan; Ramanathan, Ramesh K et al. (2014) Dual blockade of epidermal growth factor receptor and insulin-like growth factor receptor-1 signaling in metastatic pancreatic cancer: phase Ib and randomized phase II trial of gemcitabine, erlotinib, and cixutumumab versus gemcitabine plus erlotinib (SWO Cancer 120:2980-5
|Goldkorn, Amir; Ely, Benjamin; Quinn, David I et al. (2014) Circulating tumor cell counts are prognostic of overall survival in SWOG S0421: a phase III trial of docetaxel with or without atrasentan for metastatic castration-resistant prostate cancer. J Clin Oncol 32:1136-42
|Skinner, Eila C; Goldman, Bryan; Sakr, Wael A et al. (2013) SWOG S0353: Phase II trial of intravesical gemcitabine in patients with nonmuscle invasive bladder cancer and recurrence after 2 prior courses of intravesical bacillus Calmette-Guérin. J Urol 190:1200-4
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So here's this weeks question: What is one of your favorite soups?
My absolute favorite soup is broccoli and cheddar. Togo's has the very best. A close second would be clam chowder.
My absolute favorite soup is broccoli and cheddar. Togo's has the very best. A close second would be clam chowder.
Well, my favorite soup is probably my Southern Stew. Or my mother's chicken soup. Or my chili. Or Al's son-in-law's turkey with wild rice. Or anything from Olive Garden. :)
I love soup.
The end.
Have a lovely day, Sandee! big hugs xoxo
Something with meat in, I hate tomato, I like it chunky..LOL Have a wonderful day, big hugs xx00xx
Mollie and Alfie
Plain old tomato is my favorite, but chicken noodle is okay too.ReplyDelete
homemade potato/corn chowderReplyDelete
My wife's home made vegetable/beef soup. It is just the best. Second place goes to my own chunky chili...that qualifies as a soup, right?ReplyDelete
Home made - puréed root vegetables, thickened and spiced up a bit :)ReplyDelete
a nice chilled soup on a cruise ship would be my favorite! ha ha
smiles, bee
I like Vegetable Beef. c-)ReplyDelete
Mrs. C makes a fabulous African peanut and chicken soup that is spicy and delicious. it can be eaten as soup or ladled over rice.ReplyDelete
French Onion, Split Pea is a close second.ReplyDelete
Tortellini. Any many, many more! Love one-dish meals.
Big hugs, honey...
Questions? I love to answer questions... almost as much as I like to ask them! :-) I love all kinds of homemade soups, but if I could go back in time, I'd sure love to sit down to a huge bowl of my mother's ham and bean soup, and my father's oyster stew. Good memories - delicious fare! I can make them, but it's just not the same. :-)ReplyDelete
I absolutely love oxtail soup and dip bread into it :-)
Have a souplicious week :-)
Pumpkin soup is now my favourite soup. Many years ago my favourite soup was peas soup but suddenly it started making me ill. Enjoy the rest of your Wednesday Sandee.ReplyDelete
I like baked potato soup! sandieReplyDelete
Michelle's homemade Minestrone and 2nd place goes to Michelle's homemade Pumpkin SoupReplyDelete
depending on the time of the year, winter time it's got to be Potato soup,spring Beet soup,summer broccoli and cheddar,fall minestrone
:P :):-f
Roasted Red Pepper and Tomato with a grilled cheese sandwich! :)ReplyDelete
I like a hearty soup. All liquid doesn't do it for me.
Cheesy potato or steak and potato
Thank you for stopping by my little corner of the blogosphere. All comments are very much appreciated.
♥♥♥Have a terrific day.♥♥♥


text:
Quality Management Systems
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Logos, help & guidance
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by SafeContractor
Health and Safety Management
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Why choose Alcumus?
Our 92% retention rate reflects our exceptional customer service. We know every business is different, so we'll work closely with you to develop a tailored solution. Alcumus supports the health and safety strategies of FTSE 100 companies, SMEs, and everyone in between – so with Alcumus, you know you're in safe hands.
Our experienced consultants understand the minefield of evolving legisation and the potential impact of non-compliance on a business. With several Chartered Members of IOSH who are also OSHCR registered, Alcumus consultants are fully qualified to offer guidance and act as your 'competent person'.
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Monday, September 12, 2011
Wednesday, September 7, 2011
Make yourself at home!
Timmy found a forever home is in Virginia with Peggy Carey. I drove and met her halfway in PA. Timmy has his own Facebook page and I love watching him get big. We miss Timmy!
Sugar Pop Swap is still here. She is just one of the crew. She does love it here and I am not really trying to place her yet. I am waiting for that perfect somebody. She is kind of quarky, so I am protective of her. Many people want to adopt the perfect pet. She is not too much of a lap cat, but she is hilarous!
Posted by Jenny Carter at 11:59 AM No comments:
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O-Scale Lionel Illinois Central Switcher (#41) Custom Decorated, Runs Well
Sold for:
Start Free Trial
or Sign In to see what it's worth.
- Sold Date:
- Source: eBay
if you won 1 lot, or wait for my invoice if you won more than 1 lot
if you won 1 lot, or wait for my invoice if you won more than 1 lot
I had an O-scale/Lionel layout & collection in the 1980s. This has been in storage since 1987 and just unpacked this week. Lionel 41 US Army switcher colorfully redecorated for Illinois Central. Runs well, but it has been in storage 26 years so you should lub/oil it before running it.
SHIPPING $14.50 priority mail to USA. (Just in case you don't know, ebay/paypal skims 15% of your shipping payment off the top, so I only receive 85% of what you pay for shipping, which is normally less than my actual cost of postage & insurance.)
RETURNS I will accept a return if there is a significant error in the description.


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This exhibition explores elements of motion by featuring dynamic kinetic art sculptures that demonstrate movement through one or a combination of technologies including mechanical design, human interaction, wind or solar power.
Local and regional artists were selected by a juried panel and features works-of-art created by: Matthew Dockrey, Nolan Dost, Steven Jendro, Naveen Khan, and Ashwini Sedekar.
More information can be found here.


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View Exercise DVDs
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Published on 04 October 2010 08:00 AM
The Continuous Household Survey Bulletin 2009/10 has been published by Central Survey Unit of the Northern Ireland Statistics and Research Agency (NISRA).
The Continuous Household Survey (CHS) is one of the largest continuous surveys carried out in Northern Ireland. It is designed to provide a regular source of information on a wide range of social and economic issues relevant to Northern Ireland. The survey is based on a random probability sample of the general population resident in private households throughout Northern Ireland. The survey has been running since 1983 and in addition to providing up to date annual figures it now reflects changing trends in Northern Ireland over a period of more than 25 years.
The bulletin provides summary findings from the 2009/10 round of the survey based on the responses of 2,764 Northern Ireland households. It includes information on household structure and families, housing and accommodation, consumer durables, health, finance, educational attainment, environmental issues, sport and leisure and smoking. Some trend information from previous years of the survey are also highlighted.
The survey's key findings include the following:
Household Structures and Families
Housing and Accommodation
Consumer Durables
Educational Attainment
Environmental Issues
A copy of the bulletin is available from the Central Survey Unit web site at www.csu.nisra.gov.uk. The CHS web tables, which contain extensive information on a wide range of topics from when the survey began in 1983, are also available on the Central Survey Unit website at www.csu.nisra.gov.uk/survey.asp29.htm.
Alternatively, copies of the bulletin and tables can be obtained from:
Central Survey Unit NISRA McAuley House 2-14 Castle StreetBelfastBT1 1SY
Tel: 028 9034 8202Fax: 028 9034 8276Email: email@example.com
For more information:
Call Age NI Advice:
0808 808 7575


text:
Nungambakkam, Jan. 8: Spain's No. 2 seed Roberto Bautista Agut underlined his class and ..
Posts Tagged 'Spain'
Spain's Bautista Agut clinches Aircel Chennai Open trophy
Bautista Agut and Daniil Medvedev to clash for Aircel Chennai Open title
Nungambakkam, Jan. 7: Spain's No. 2 seed Roberto Bautista Agut will take on Russia's r ..
Junior Hockey World Cup 2016: The Indian dream continues
The Indian colts mounted a dramatic comeback to beat Spain 2-1 and reach the Semi Finals o ..
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The FIFA Confederations Cup 2013 event kicks off tomorrow, June 15, in Brazil. The STAR Sp ..


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Conservative Books and DVD's
South Carolina Congressman Jeff Duncan, a GING-PAC endorsed legislator, has just endorsed Chad Connelly for Mick Mulvaney's seat in the House of Representatives.
Connelly is former chairman of the South Carolina GOP and became the national director of faith engagement for the Republican National Committee during the Trump campaign. He is one of seven Republicans seeking Mulvaney's seat. The GOP primary takes place on May 2.
According to Connelly: I've never held public office but have been a small business owner for over 20 years. After my US Army and SC Army National Guard days as a Tank Commander and Platoon Leader, I spent eight great years working in and learning about corporate America. That's when I took another leap by deciding to write a book on American Christian history and the free enterprise system. I have been working ever since to encourage Christians to engage more in the public arena.
Over the past 3½ years, I have had the privilege of traveling and speaking in over 40 states and in front of over 80,000 pastors and priests and faith leaders encouraging them to re-engage this culture and take back our land! So many of you have challenged me to do more than just talk about this engagement but to run for public office myself. Although I've worked for years as a volunteer and as SC Republican Party Chairman, I'm actually pretty new to being a candidate. I have told people who have encouraged me to run that it would have to be God Himself to make an opportunity available. With Donald Trump's historic and unpredicted win, we have been shown that opportunity.
Read more about Chad Connelly here: Chad Connelly running for Congress to fill Mick Mulvaney's South Carolina shoes – Washington Times.


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Avonstone43 Feedback reviews, 100% positive
Avonstone: Natural stone specialists ; stone masonry ; restoration ; conservation ; landscape garden construction; architectural carving; stone cleaning; paint removal; structural alterations. Member of The Guild Of Master Craftsmen
Latest Stonemasonry feedback review:
By emilyh123_89 on 1st Sep, 2017
MARKTHAMLIN17 Feedback reviews, 100% positive
Personable, experienced stonemason working to a high standard; able to also undertake hard landscaping and garden work including walls of various composition, fences, patios, etc. Hard-working, efficient, and conscientious; I take pride in completing the job properly. Good...
Latest Stonemasonry feedback review:
By jlb_44 on 31st Oct, 2017
Stibro Worktops15 Feedback reviews, 100% positive
My name is Peter. I have 15 years experience with fitting stone worktops. I am competent at working with granite, marble & quartz. I am able to help you source your materials and help with templating. I have a keen eye for design and can advise you about the best worktop for...
Latest Stonemasonry feedback review:
By woodlandscape on 11th Nov, 2017
Mark Cater21 Feedback reviews, 100% positive
I offer a wide range of trades. Covering all areas of work. I am very hard working and offer a very competitive rate. I keep very good communication with the customer. I am reliable and always start work on time.
Latest Stonemasonry feedback review:
By andrew_659 on 29th Jan, 2017
A & D Stonemasonry10 Feedback reviews, 100% positive
We are 2 experienced stonemasons who have been in the industry for 30 yrs. We carry out all types of masonry from stone carving, restoration, new builds, walls, conservation works. We offer a reliable and friendly service with competitive rates.
Latest Stonemasonry feedback review:
By wills_30 on 26th Oct, 2017
TJ Building (Bristol) Ltd28 Feedback reviews, 100% positive
T . J . Building Services Bristol is a new company and within its second year of business has been building a reputable, competitive business with 100% customer satisfaction. With 13 years experience and a wide range of skills, and having access to various well established,...
Latest Stonemasonry feedback review:
By tkelpie on 8th Nov, 2016
A and D Stonework6 Feedback reviews, 100% positive
My name is Darren, I live in Monmouthshire. I have been a stonemason for 18 years, trained by some amazing craftsmen. I am a perfectionist, everything has to please my client, any aspect of stonework and also bespoke slate items. Thank you
Latest Stonemasonry feedback review:
By sawmill_47 on 8th Aug, 2017
Arch Masonry7 Feedback reviews, 100% positive
Hi we are fully qualified stonemason with 10 years experience. We are small masonry contractor specialising in restoration, rubble walling, stone fixing, conservation and paint removal. We are trustworthy and honest person. Feel free to contact us for free quotation. No job...
Latest Stonemasonry feedback review:
By peli0011 on 12th Oct, 2017
ACT Masonry Limited10 Feedback reviews, 100% positive
We offer quality work and very reasonable prices. We are more than happy to provide free Quotations and advice.
Latest Stonemasonry feedback review:
By sarah_p_48 on 17th Sep, 2015
Morthanstone8 Feedback reviews, 88% positive
I am a qualified and experienced stonemason and conservator. I have worked on National Trust and English Heritage listed buildings. I can supply the same standard of care for your residential property that I have provided for National Trust and English Heritage Buildings.
Latest Stonemasonry feedback review:
By nathan_55 on 3rd Nov, 2017
welsh garden construction company35 Feedback reviews, 100% positive
My company works in a professional manner with your best interests paramount. We wear identifiable uniforms and, whilst the nature of the work we do causes disruption, we never lose site of the fact that it's your home.
Latest Stonemasonry feedback review:
By tom_267 on 15th Sep, 2014
A Spec building & landscapes37 Feedback reviews, 100% positive
A.spec building & landscapes are a small family run building, landscape and stonemasonry company, Giving professional advice from our many years of experience ensures you get the best service possible and satisfaction from start to finish. We truly believe in going the...
Latest Stonemasonry feedback review:
By len_81 on 5th Oct, 2017
L Morris Stonework & Building5 Feedback reviews, 100% positive
I am Lee Morris. I am a Stonemason/builder since 1997. FMB member. I love working with stone, lime & traditional methods. I specialize in barn conversions and old restorations etc. Visit my website for full details. Thank you.
Latest Stonemasonry feedback review:
By rhyswg on 1st Aug, 2016
Llandaff City Stonemasons10 Feedback reviews, 90% positive
As a company we strive to provide a professional and friendly service to all our clients, who include architects, contractors and conservators, as well as private residential clients.
Latest Stonemasonry feedback review:
By davidg_90 on 16th Nov, 2016
Ed Shaw Masonry9 Feedback reviews, 100% positive
All aspects of brickwork and stone-masonry competently undertaken. From newbuild to restoration and conservation, cob, lime repair, architectural and decorative masonry designed and made by hand. Many years experience at brickwork and stonework, very professional and tidy.
Latest Stonemasonry feedback review:
By ariesgirl on 12th Sep, 2016
Need a tradesman?
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Well, because of UAC, one needs to change the folders and files' ACLs under "%ProgramFiles%\Microsoft SDKs\Windows\v6.0\Samples" in order to be able to create files (e.g. executables, object files, ...).
So this time I decided I would give ICACLS a try and it worked beautifully. Under the parent folder, I ran:
C:\Program Files\Microsoft SDKs\Windows\v6.0>icacls samples /T /grant:r Everyone:F
FWIW, I was running build 6.0.5824. Don't you love command-line tools?


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Niki Immonen and his American boyfriend Charlie Hale are all set for a Finnish-style family Christmas at Niki's family's country cottage, hoping to stay for a week.
Only…the place is way out in the wilderness, miles from any semblance of civilization, with no electricity and no running water, let alone hot water, and loads of relatives are constantly close by.
What can two lovers do for privacy and intimacy out in the boondocks? Will they choose the guest bedroom, or the sauna, or the snowy woods? And what will Santa bring these boys for Christmas?
After all, they have not been naughty, but very nice—to their family, and especially to each other.
Presents or no, the best gift for Christmas is always love.
I know I am a little late in posting this. Sorry guys! The holidays sure did sneak up on me fast! This book sure did make me homesick for all the holidays we have spent up in the Northwoods. I know it's not Finland but it does get really snowy and cold and my in-laws live way out in the boonies. I miss that feeling of being snowbound and having nothing to do but spend time with the family and enjoy the holidays.
Anyway, this story was a cute holiday novella. In addition to being about a couple whose relationship has lasted more than 5 years, it is also about home and family. Ms. Laine did a fabulous job of painting a loving family unit who accepts everyone for who they are. It was a heartwarming tale that really got me in the mood for my own family time this season. We also got an interesting glimpse into some of the Finnish customs for the holidays. I can't say that I have ever much given thought to how people in Finland celebrate a Christmas but I am now do. It was a beautifully detailed look at a traditional (I assume) holiday. All in all this book was just the right book for a holiday read.
That being said, there were also some hot sex scenes and fun in a sauna. This book would be good to read any time of the year for its themes of love and family values. I give it 4 stars.


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A DAD made a "miraculous" recovery after suffering a fractured skull and smashed pelvis in motorbike crash so he could walk his daughter down the aisle on her wedding day.
Graham Holdsworth was in a coma for three weeks after colliding with a pick-up-drawn horsebox while out on a drive in September last year.
Mr Holdsworth, from Horden, sustained multiple life-threatening injuries in the collision on the A168 between Topcliffe and Thirsk.
As well as a fractured skull, he smashed his pelvis and shattered his legs.
The Great North Air Ambulance Service flew its doctor-led trauma team to the scene and flew him to the James Cook University Hospital in Middlesbrough.
"They didn't think I was going to survive," he said.
His family were braced for the worst, but little by little Mr Holdsworth began to improve.
After months of rehabilitation, he forced himself out of his wheelchair and onto his crutches in time to walk his daughter down the aisle on her wedding day.
"There were a lot of goals along the way but that was my main one," he said. "It meant so much to me and my family."
Mr Holdsworth's daughter Cleo Millgate, 29, of Darlington, said: "Throughout his recovery, and even when he was unconscious, I kept saying to him 'you're walking me down the aisle, you've got six months'. It did give him focus.
"It was the proudest moment of my life to have him by my side, walking me down the aisle on my wedding day. It's difficult to express how much that meant.
"I can't thank the air ambulance medics enough for what they have done for our family."
Mr Holdsworth's partner Barbara Petrie, of Norton, is now raising money for the air ambulance, which does not receive Government funding and relies on public donations to survive.
Ms Petrie said: "It really was a miracle. Without the air ambulance getting him to hospital so quickly it would have been a very different story."
Mandy Drake, deputy director at the charity, said: "It is great to hear that Graham is on the mend after what was an horrific incident. The money raised by Barbara will go directly to keep the aircraft flying so that the service can continue to fly life-saving missions throughout the region."
Ms Petrie takes part in the Middlesbrough 10k this weekend. To sponsor her, visit: https://www.createanddonate.co.uk/to/middlesbrough-10k-september-8th/


text:
Legal Question in Disability Law in Virginia
Can Senior housing complex with 100 apartments have less than 3 handicap parking spots?
Asked on 12/08/11, 8:41 pm
1 Answer from Attorneys
Michael Hendrickson Law Office Michael E. Hendrickson
The specific number of such spaces could depend upon the requirements of local zoning and/or other ordinances which may apply rather than anything specifically to do with the ADA.
Answered on 12/09/11, 4:51 am


text:
Learning Experience
Data Collection and Display
Process Mapping
Apply Basic
Lean Concepts
Kaizen (philosophy of ongoing improvement):
Team approach that quickly identifies inefficiencies in a process and generates solutions.
When to Apply Kaizen?
Kaizen Framework + Deliverables
Sample Event Charter
Business Case:
How will this event drive strategic goals?
Supports initiative to improve efficiency of admissions process enabling Guelph to process offers of admission quicker while reducing use of paper.
Why is it important to do now?
OGS projects growth in enrollment and therefore growth in conditional offers processed
New process of uploading unofficial documents will lead to more conditional offers to be processed
What customers will benefit?
OGS staff responsible for processing offers of admission
Applicants awaiting response from admissions
Problem Statement:
What problem is the event addressing?
The need to manually reviewing documents received to determine whether they are associated with an incomplete application or a conditional offer
Where and when does the problem occur?
When documents are received in the mail for scanning
What are the defects with current process?
Workstudy students scan incoming documents without knowing whether the intent of the document submitted was to complete an application or to satisfy a condition on an offer of admission
Baseline Perforance?
How many conditional offers are processed per academic year?
Average time it takes for a 'conditional offer' to be processed as a 'final offer'?
Measure date imported vs date application status changes from conditional to final? (data pulled from ImageNow)
Applicant mails in document
Applicant requests status update
Admin are backlogged
OGS receives doc.
Reviews doc type
Marks a regular doc or final doc
Updates status to rec'd in SIS
Inserts into SA bin
SA checks bin and verifies document
SA verifies document correctly processed
SA processes offer from conditional to definite
Course Feedback:
Useful for small scale process improvement initiatives
Integrates principles and methods from other methodologies
Simple, identifies quick fixes, determines cause and affect
Must have data available
Generate Solution Ideas
Discoveries from Lean Analysis
Project Goals
Root Causes
Ideas from other projects
Performance Targets
Results from VOC:
Process is time consuming
Frequent errors
Challenges in training work study students to Q/A documents
Applicants phoning in to request status of their offer
Root Cause Analysis: 5 Whys
Some of this information can be done by searching for information within ImageNow and exporting to CSV to be manipulated in Excel
i.e. time in queue, date imported, last activity, etc.
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David Handsoron 23 January 2014
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