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Laura Marcus - The Tenth Muse: Writing about Cinema in the Modernist Period
2008 | ISBN: 0199230277 | English | 584 pages | PDF | 5 MB
The Tenth Muse explores writings on the cinema in the first decades of the twentieth century. Laura Marcus examines the impact of cinema on early twentieth-century literary and, more broadly, aesthetic and cultural consciousness, by bringing together the study of the terms and strategies of early writings about film with literary engagement with cinema in the same period. She gives a new understanding of the ways in which early writers about film - reviewers, critics, theorists - developed aesthetic categories to define and accommodate what was called 'the seventh art' or 'the tenth muse' and found discursive strategies adequate to the representation of the new art and technology of cinema, with its unprecedented powers of movement.
In examining the writings of early film critics and commentators in tandem with those of more specifically literary figures, including H.G.Wells and Virginia Woolf, and in bringing literary texts into this field, Laura Marcus provides a new account of relationships between cinema and literature. Intertwining two major strands of research - the exploration of early film criticism and theory and cinema's presence in literary texts - The Tenth Muse shows how issues central to an understanding of cinema (including questions of time, repetition, movement, vision, sound and silence) are threaded through both kinds of writing, and the ways in which discursive and fictional writings overlapped.
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My first white jelly polish! This beautiful polish was purchased in Istanbul, and it's Flor Mar 319. It's also sold as part of a french manicure set, so I suppose it can be used as the base for a french manicure. It is white, it is jelly, and it took me nearly 5 coats for what you see here because I was impatient in waiting between layers and it got streaky.
It's a great palette cleanser, it's a really soft white, and squishy looking!
As you can see there are some patchy spots.
I'm glad I bought two bottles of this, it's really nice! I don't have Essie Marshmallow, but this may be similar to it. However, this polish does have a slight grey cast to it.

subset: commoncrawl


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Sunday, October 06, 2013
It's been about a week and a half since I started looking at my calorie count. I've made little steps in raising my daily amounts while still being close to my WW daily points. I use my Activity Points earned more often now to make up for the difference. So far it seems to be helping. Since eating those extras I have seen small drops on the scale and a big lift in my energy every day. I don't feel like falling over exhausted every few hours.
Part of this process has been eating some foods that I haven't had in a long while. Processed foods like Betty Crocker potatoes (my boyfriend loves them) or tonight, Pillsbury biscuits. I have learned that I'm not missing them. At all. I find them to be odd tasting, if having any taste at all, and not worth the points or the lack of loss on the scale. I just don't like that stuff anymore.
I have also noticed over the last few weeks that my kickboxing just doesn't pack the punch it used to. Yup, pun totally intended :D I have to work much harder than the actual workout is to get my heart rate up and even then it's not up by as much as it should be. It gets into the moderate range but just barely. It used to be a good border on high level workout. This is good and bad. It means that my body and heart are stronger and healthier. That's what I want. It also means that I have to find something else to do. So, on to aerobics. A new workout pattern that I don't know means I'll have to work hard to keep up and learn the moves. That means it should get the ticker ticking faster. I also found some different kickboxing routines, the Walk Away the Pounds videos and several others on Youtube. I'll give them all a try.
I have 4 weeks to try to reach my birthday goal. 8 more pounds. I don't know if I'll make it or not. Either way it will go at some point. I just thought it would be good to do by then. Guess we will have to wait and see. I better not eat those darn biscuits again!
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UPS is a household name and one of the most highly regarded American corporations by customers and investors alike. Who hasn't been delighted by a right-on-time delivery, one of the 18 million UPS makes every day? Founded over 100 years ago, UPS has moved steadily up the Fortune 500 as so many other corporations have dropped off. So what's the company's secret? Just ask a driver!
Ron Wallace was a UPS driver for six years before he rose through the ranks to become president of UPS International. In other companies that might be extraordinary, but for UPS it's par for the course. UPS has a unique people culture. It's like a family. Package loaders call executives by their first names and vice versa. The company almost always promotes from within. Lifetime employment is common. Most employees own UPS stock. Wallace credits this spirit of "we, not me" with the company's success - and his own. As he puts it, working at UPS gave him a PhD in teamwork.
Instead of writing a typical business memoir that celebrates the leader as celebrity, Wallace shares vivid stories that focus on the people he worked with, the challenges they overcame, and the simple principles and practices that make up the UPS way. He exhorts his fellow leaders to grow their people, not just their business plans. The leadership style described in this book is simple and direct - and it works. The straightforward and easy-to-understand lessons provide a blueprint for an individual or company to build on past successes and adapt to future challenges. This is a must-listen for anyone aspiring to become a great leader.
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Middlebury College freshman profile
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Information about Middlebury College freshman profile, and registering for elective seminars and lectures. Which college degrees give you the best chances of entering a successful career path after graduation? Concentrating on Middlebury College freshman profile, for example, may give you additional focus in the admissions selection process. Check with the admissions office for assistance with prerequisites, course registration deadlines, and college degree program requirements. Please use the form above to request admissions info for Middlebury College.
Research demonstrates that college freshman taking a full courseload go on to complete their degrees at a much higher rate than those students who study part-time. When choosing a major, plan ahead and be sure that you are picking courses that will meet transfer requirements of other colleges and universities later on. Further, by choosing your major early, you may be able to take some required core classes in a community college, saving both time and tuition fees.
Look at all the schools in your state first, as in-state tuition may be lower for state residents. The course catalog will outline which classes are required for a particular major, and what minimum GPA you'll need to maintain your class standing. Please contact the academic advising staff at the school you are interested in applying to about their specific guidelines. Beyond major requirements within the admissions department, you may consider Wallace Community College GED exams for complementary electives to your primary course of study.
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A glimpse at a possible future career...
Venice Travel Blog› entry 2 of 5 › view all entries
I was only in LA for the weekend, so I knew time was of the essence. I got my rental car and my gps device (best invention ever!!!), settled into my hostel, Hostel California, and was off to take in as much of
I had to hurry to Venice Pier, which is famous for having spectacular sunsets.
While I was shooting a few sunset photos, I saw that right next to me there was a professional photoshoot, using the backdrop of the sunset.
Now I didn't want to interfere, but I thought that it would be cool to document the photoshoot, the process behind the scenes, the set up of the shots, the photographer at work, and I got to work.
I took some photos, and upon reviewing some I noticed that a few stood head and shoulders above the rest and were quite good. One of the people standing around the shoot took notice to my photos and was overly delighted at hot a few of my photos came out. She happened to be the mother of one of the models and one of my photos really captured her daughter exquisitely. The mother and a few from the models' entourage advised me to show the photo to the photographer, to see if maybe he would like to use it as part of his photoshoot or collection.
I walked over to the photographer, and he was very delighted to see the photo, "I didn't notice that angle, the photo came out great" he said. After the high praise from the photographer, who knows maybe this might turn into a new career for me someday :)
I was beat, and so I went back to my hostel, chilled out, relaxed and swapped stories with fellow travelers at my hostel.


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Fridge connection By Ricardo on 9/28/2016Ricardo would recommend this product to a friendJust in case anyone is looking to run an RO line to your ice maker on your fridge. I bought multiple fittings that did not work. This fitting went right on to my fridge with no leaks after a little Teflon tape.
Yet another quality Mur-Lok product By Nick on 4/5/2013Nick would recommend this product to a friendI bought two of these adapters to use on my float valves in my Brute containers. They fit perfectly onto the threads, so now I can quickly connect/disconnect the RO tubing when I need to move around the Brutes. This may not be an issue for those of you with permanent spots for your Brutes, but for those of us that need some flexibility, this does the job well.


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Magnetism And Intro To Electricity: Question Preview (ID: 3444)
Below is a preview of the questions contained within the game titled MAGNETISM AND INTRO TO ELECTRICITY: Magnetism And Intro To Basic Electricity Concepts .To play games using this data set, follow the directions below. Good luck and have fun. Enjoy! [print these questions]
Play games to reveal the correct answers. Click here to play a game and get the answers.
The regions on a magnet where the magnetic force exerted is the strongest are called what?
a) magnetic domains
b) north, sounth, east, and west
c) magnetic poles
d) magnetic force lines
What is probably the largest object we know of that functions as a magnet?
a) a compass
b) the Earth
c) the moon
d) giant magnets in labs
Which is a correct statement?
a) Two north poles or two south poles of any magnets attract each other.
b) There is a huge bar magnet imbedded in the axis of the Earth.
c) If you cut a magnet in two pieces it destroys the magnetic properties of the magnet.
d) The north pole of one magnet will attract the south pole of another magnet.
The hundreds and hundreds of small areas containing a north and a south region within a given piece of magnetic material such as iron or nickel are called:
a) ranges
b) domains
c) poles
d) magnets
How is a non-magnetized iron nail made into a magnetized one?
a) Aligned with a magnet or electric current passed through so domains line up.
b) Stored for a long period of time next to a magnet.
c) Put on top of paper and floated in a small amount of water.
d) Dipped in special paint.
Electric current is the movement of what along a path?
a) magnets
b) electrons
c) atoms
d) protons
Which does not apply as a description of alternating current?
a) The type used when you plug something into a wall outlet in your home.
b) The current switches directions at a frequency of 60 cycles per second.
c) The type used when you power something with batteries.
d) Normally generated at large power plants.
If a magnet is moved near a wire, a current can be created. This process is called what?
a) magnetic field lines production
b) electromagnetic induction
c) generation
d) transformation
What type of metal is used most often for wires for conducting electricity?
a) gold
b) zinc
c) nickel
d) copper
For what reason is copper a good choice for wire for conducting electricity?
a) It has an outer shell electron that moves fairly easily.
b) It is very inexpensive and easy to find.
c) It conducts better than any other substance known to man.
d) Its electrons stay in one place so they are easy to make move when needed.
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Armenia has proposed that the prices of natural gas and other "strategic" commodities traded within the Russian-led Eurasian Economic Union (EEU) be set in Russian rubles, rather than U.S. dollars, the Armenian government confirmed on Wednesday.
According to the Belarusian news agency BELTA, Prime Minister Hovik Abrahamian floated the idea on Tuesday at a meeting of the prime ministers of the EEU member states held in Grodno, Belarus. Abrahamian was reported to stress the need to reduce the high degree of "dollarization" in trade among Russia, Kazakhstan, Belarus, Armenia and Kyrgyzstan. For that purpose, he said, they should "carry out mutual trade in strategic goods on the basis of the ruble."
Abrahamian's spokeswoman, Gohar Poghosian, confirmed the information. "He primarily referred to energy resources," Poghosian told RFE/RL's Armenian service (Azatutyun.am). "But ruble-denominated trade could also apply to other strategic commodities."
It is not clear whether the Armenian proposal was backed by any of the other EEU member states. Only two of them, Russia and Kazakhstan, are rich in oil and gas. Russia is also one of the world's leading exporters of wheat.
President Serzh Sarkisian apparently voiced the same proposal when he met with his Russian counterpart Vladimir Putin outside Moscow on Monday. "The price of energy resources for Armenia remains the key issue," he told Putin. "In this crisis situation, exchange rate fluctuations have a very painful impact on [Armenian energy] tariffs, and I very much hope that we will find new solutions, good solutions."
A nearly 17 percent depreciation of the Armenian dram recorded late last year was the main official rationale for state regulators' decision in June to raise electricity prices in Armenia for a third time in two years. The regulators argued that the weaker dram has pushed up the cost of Russian natural gas generating around 40 percent of Armenia's electricity.
That explanation did not satisfy most Armenians. Thousands of them demonstrated in Yerevan against the price hike in late June and early July. The protests forced the Sarkisian government to subsidize the energy tariffs for households and some small businesses.
The Russian currency has weakened much more drastically over the past year.


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PHILADELPHIA -- Jason Peters was angry with himself. He gave up a sack to the Kansas City Chiefs' Tamba Hali because he thought Michael Vick was taking a three-step drop instead of a five-step drop.
"He just ran the edge and got me," Peters said. "He didn't really beat me. Bad technique."
This conversation took place in Deccember. The sack happened in September, while Peters was playing with a finger broken so severely, an X-ray showed the two pieces of bone weren't touching.
That explains a lot about Peters' expectations of excellence. That in turn explains how an undrafted rookie tight end who got $5,000 to sign with the Buffalo Bills just signed a five-year, $51.3 million contract to finish his career as the left tackle of the Philadelphia Eagles.
The deal includes nearly $20 million in guaranteed money, the most ever for an offensive lineman Peters' age, 32, or older.
"He's a unique player," Eagles general manager Howie Roseman said Wednesday. "When you talk about the physical gifts that he has, there's not many men on this earth who are as physically talented as he is. His level of play was unheard-of. He's got a chance to be a Hall of Fame-type player in an Eagles uniform."
Peters was going into the final year of his contract. The Eagles approached him before the season about an extension. Vincent Taylor, Peters' agent, said there were "soft talks" throughout the season. Peters, who missed all of 2012 while rehabbing a torn Achilles tendon, returned to Pro Bowl form in his first season under coach Chip Kelly.
For Peters, the appeal to signing an extension now was simple.
"The security," Peters said. "I guess they didn't want to risk losing me. I didn't want to go anywhere, and I let them know that. We got it done."
That Achilles injury factored into the thinking on both sides. For Peters, it was an example of how quickly a career can be threatened. He tore it while working out in March 2012, then reinjured it in an accident. It took two surgeries and months of rehab to get back on the field.
"I think that was one of Jason's motivations," Taylor said. "He said, 'Vince, I just want peace of mind. Because you know me, I don't know any other gear besides 100 percent. I want to know if I go out and something happens while I'm giving it all I've got, then I'll be OK.'"
For the Eagles, Peters' absence through a disastrous 4-12 season made them appreciate his presence in 2013 that much more.
"When you lose a player like that, the ramifications along your offensive line and the things you need to do to recover are extremely hard," Roseman said. "I can't tell you that, when we went and looked at our team with that hole, without his name, and then go back and look at the tape from this year, that those thoughts don't come across. When he's out on the field, we all feel different."
Peters played most of 2013 with his fingers taped together because of that fracture. He had a minor quadriceps injury that forced him to miss a few snaps. But he dropped more than 20 pounds in Chip Kelly's conditioning and nutrition program and said he felt better and more energetic than ever.
So Peters said he has no doubts he can play another five seasons, which would take him to age 36.
"I think so," Peters said. "And they obviously think so. They wouldn't have given me the contract if they didn't. I'm definitely going to live up to it."


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Service tools
Navigation path
Photo: Turku Touring
There are several international flights arriving directly to Turku Airport.
There are several international flights arriving directly to Turku airport (location). The airport is approximately 8 kilometres from the city centre, which can be reached by taxi (approximately 20 €) or by local bus number 1 (3 €).
It is also quite convenient to arrive in Helsinki-Vantaa airport. There are long distance bus connections leaving approximately every hour from the airport to Turku. The travelling time between Helsinki-Vantaa airport and the Turku bus station is about two and a half hours. It costs around 50 €.
Flight connections
The national train company VR departs from the local railway stations all throughout Finland. There are two railway stations in Turku: The main railway station (rautatieasema) which is at the city centre at Ratapihankatu 37 and the Kupittaa railway station which is about 1.5 kilometres from the city centre. Only the trains coming from the direction of Helsinki stop at Kupittaa.
Railway traffic & railway stations in Turku
The national long distance bus service Matkahuolto departs from local bus stations all throughout Finland. The final stop in Turku for long distance buses is at the Turku Bus Station (linja-autoasema) which is located near the city centre.
You can search for timetables for the busses from Helsinki-Vantaa Airport to Turku by entering:
Place of departure: Helsinki-Vantaa Airport
Destination: Turku bus station
Please note that in some of the routes, there is a change of bus in Espoo during the trip from Helsinki-Vantaa airport to Turku. The bus personnel will inform you about the change and the transfer bus will be waiting for the passengers. Your luggage will be transferred by the bus personnel. If you have any doubts about the transfer, you can always ask the bus personnel to help.
There are two cruise lines which have regular connections between Stockholm and Turku: Viking Line and Tallink Silja Line. The Port of Turku (Turun Satama) is approximately two kilometres from the city centre and can be reached by local bus number 1.
Boat traffic and connections in the archipelago:
This is the conference venue.
Köydenpunojankatu 14
Turku 20100
Logomo is the main site for the European Maritime Day Conference. The venue is an old locomotive engineering workshop which has been refurbished, and turned into a contemporary venue perfectly suitable for hosting diverse types of events.
Converted by Vapaavuori Architects over a period of several years up to 2014, Logomo offers a 1,700 seat concert hall, a series of smaller halls, the Byra small business centre, Logomo Kitchen restaurant and meeting facilities over 27,000 sq m. A key - and innovative - feature is a massive mobile seating stand, riding back and forth on compressed air cushions: this enables the main hall to expand to accommodate a rock audience of 3,500, and marks Turku's role as City of Culture.
The Logomo Cultural & Conference Centre is located in the centre of Turku, close to the main railway and bus stations. It is easy to reach by foot, bicycle, or public transports (buses 20 and 61 stop there).
After the conference:
On 19 May from 15:00 onwards a shuttle bus from Logomo to Turku airport will be available.
The city of Turku welcomes the participants of the conference for the networking reception on 18 May 2016.
Linnankatu 72
Turku 20100
Forum Marinum is a National Specialist Museum for Finnish maritime and naval history. It is located close to the sea, beside the River Aura, and next to Turku Castle. The museum has both temporary and permanent exhibitions, a fascinating collection of vessels, and a remarkable fleet of museum ships: sailing ships the Suomen Joutsen (frigate) and the Sigyn (barque), four warships, and many small steam-powered vessels such as a tug-boat and police boat. Forum Marinum is a site for meetings and public events, and also features Café Restaurant Daphne.
Non-stop shuttle buses take the participants of the conference from Logomo to Forum Marinum after the last session of the day. Shuttle buses will also take participants back to the centre after the networking reception.
It is easy to get to Forum Marinum on foot or by public transport. The distance from the market square is approximately 2.5 kilometres and the bus no. 1 leaving from the market square and going to the harbour stops at the Forum Marinum bus stop.
You can also order a taxi by calling 02 10041.
Please be aware that when booking a room (either via email or telephone) you have to provide the hotel with the following information:
Notice: Each hotel has a different cancelation policy, please be sure to ask in case of no show or flight delay.
Please note that most of the special rates are available until one month before the Conference.
Radisson Blu Marina Palace
The Radisson Blu Marina Palace Hotel, Turku places guests on the banks of the stunning Aura River and provides 184 well-equipped, stylish rooms that showcase an intricate Baroque design. The on-site Restaurant Grill it! Marina serves delectable barbeque dishes prepared with the freshest ingredients, while the Coffee Bar by Coffee House offers snacks and drinks 24 hours a day. Opt for a rejuvenating spell in one of the saunas, and visit the fitness center to maintain your exercise regimen while traveling. The meeting facilities overlook the Aura River and provide ample modern equipment for a successful event.
Radisson Blu Marina Palace
Linnankatu 32, 20100 Turku
Room rate:
Original Sokos Hotel Hamburger Börs
Original Sokos Hotel Hamburger Börs is the most popular hotel in the city situated right in the centre of Turku by the Market Place. A legend among city hotels since 1904. 1 km from the railway and bus station, 3 km from the harbour and 8 km from the airport.
Original Sokos Hotel Hamburger Börs
Kauppiaskatu 6 , 20100 Turku
Room rate:
Original Sokos Hotel City Börs
An affordable and different hotel located across the street from Original Sokos Hotel Hamburger Börs on the upper floors (floors 5-8) of the Sokos Wiklund department store.
Original Sokos Hotel City Börs
Eerikinkatu 11, 20100 Turku
Room rate:
Original Sokos Hotel Seurahuone
A cosy hotel with excellent central location for both business and leisure travellers. 800 m from the railway station, 1 km from the bus station, 3 km from the harbour and 8 km from the airport.
Original Sokos Hotel Seurahuone
Eerikinkatu 23, 20100 Turku
Room rate:
Room rate includes buffet breakfast (vat 14 %), room (vat 10 %) and use of sauna and also pool at Hamburger Börs. Room rate is net and does not include commission.
Special rate is available until 06.04.2016. Room rate includes buffet breakfast.
Please quote the allotment code "EDM2016" when making a booking directly from our sales office:
Original Sokos Hotels
tel. +358 2 3373800 or by e-mail: email@example.com
Radisson Blu Marina Palace
tel. +358 20 1234710 or by email firstname.lastname@example.com
Hotel Scandic Julia, Turku
Hotel Scandic Julia is a modern hotel in the centre of Turku, near the shopping streets and River Aura.
Hotel Scandic Julia is one of the most modern hotels in Turku. It is located right in the centre of the city, close to the River Aura and trendy Vähätori square, which is the new culinary centre of the city with its design stores. All the city's major sights and entertainment highlights are within easy reach of our hotel, including museums and Turku Castle. All of the shopping centres, the marketplace and market hall, and the University of Turku are also all within walking distance. Scandic Julia is the 1st hotel in Turku to receive the Nordic Ecolabel according to its new criteria.
Scandic Hotel Julia
Eerikinkatu 4, 20100 Turku
Room rate:
Room rate includes buffet breakfast.
Tel: +358 (0)2 336 000 or
Email: email@example.com or
http://www.scandichotels.com/Hotels/Finland/Turku/Scandic-Julia/#.VjNYStLou9I, code: BEMD180516
Special rate is available until 19.04.2016. Please quote the allotment code "EDM2016" (or BEMD180516 via internet) when making a booking.
Hotel Scandic Plaza, Turku
Hotel Scandic Plaza is located right in the centre of Turku, near all the shopping streets and major attractions.
Hotel Scandic Plaza is centrally located in Turku, close to the market place and promenade. When you stay at hotel Scandic Plaza, you can shop at the Hansa shopping centre, located opposite our hotel, or explore the sights of Turku including Turku Cathedral. The city's cultural scene and the riverside with its river boats are also just a short walk away.
Hotel Scandic Plaza
Yliopistonkatu 29, 20100 Turku
Room rate:
Room rate includes buffet breakfast.
Tel: +358 (0)2 33 200 or
E-mail: firstname.lastname@example.com or
http://www.scandichotels.com/Hotels/Finland/Turku/Scandic-Plaza-Turku/#.VjN350bD_sR code: BEMD180516
Special rate is available until 19.04.2016. Please quote the allotment code "EDM2016" (or BEMD180516 via internet) when making a booking.
Hotel Cumulus Turku
Hotel Cumulus Turku is a friendly hotel at the heart of Turku, with a sincere atmosphere that can be felt in the common spaces as well as the individual rooms. The hotel staff greets the guests with friendly service.
Cumulus Hotel is located in Turku by the Aurajoki shore, and it is an excellent place to stay when you are on a holiday in the Turku area. In the summer, Turku offers many different events, such as the DBTL city festival – the festival area is very close to Hotel Cumulus Turku. The centre of Turku is only approximately 500 metres away from the hotel. The railway station is less than one kilometre away and the Turku Airport 8 kilometres away. There are no actual airport hotels in Turku, and therefore Hotel Cumulus Turku is a good choice also for those looking for an airport hotel in Turku.
We welcome you for a pleasant stay in the Cumulus Hotel in Turku
Hotel Cumulus Turku welcomes all visitors to the recently renewed, friendly and cozy hotel. After a night at Hotel Cumulus Turku, you will be well-rested and ready for an eventful day, whether it will be business or holiday.
Eerikinkatu 28-30, 20100 Turku
Room rate:
Room rate includes buffet breakfast.
Tel. +358 2 2181000 or
email: firstname.lastname@example.com EMD2016 or www.hotelworld.fi
Special rate is available until 19.04.2016. Please quote the allotment code "EDM2016" when making a booking.
The European Commission together with the City of Turku wish to make EMD 2016 a sustainable event, lowering environmental costs as much as feasible and taking into consideration the social and economic impact of the conference. We have minimized the carbon footprint of the conference though different actions:
As organisers, we consider that it is our responsibility to show a responsible behaviour about environmental issues and encourage others to follow us.
By serving a vegetarian lunch to 1.000 participants, we save 3 000 tons of CO2 emissions which is equivalent to the emissions produced by a mid-sized gasoline car running 4 000 km.
Participants' kits
Many hotels in Turku are environmental friendly and they have been labelled with various 'Green' labels.


text:
To try the thousands of add-ons available here, download Mozilla Firefox, a fast, free way to surf the Web!Close
Welcome to Firefox Add-ons.
Choose from thousands of extra features and styles to make Firefox your own.Close
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|Dec. 13, 2011
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My Reviews
Works well Rated 5 out of 5 stars
So far I am impressed with it's ease of use. I like the multiple translations of selected text from English to Spanish, which is all I am doing. The copy of the highlighted desired translation and paste to email works very well. Like all translators it can only do so much, as Spanish phrases are in reverse to English sometimes. But it gets closer than most. It is from Trident, and they have been at this game of translation services for some time.This review is for a previous version of the add-on (1.5.1-signed.1-signed).
To create your own collections, you must have a Mozilla Add-ons account.


text:
Results 1 to 1 of 1
November 22nd, 2003, 02:06 PM #1
What work I have done I have done because it has been play. If it had been work I shouldn't have done it. Who was it who said, "Blessed is the man who has found his work"? Whoever it was he had the right idea in his mind. Mark you, he says his work--not somebody else's work. The work that is really a man's own work is play and not work at all. Cursed is the man who has found some other man's work and cannot lose it. When we talk about the great workers of the world we really mean the great players of the world. The fellows who groan and sweat under the weary load of toil that they bear never can hope to do anything great. How can they when their souls are in a ferment of revolt against the employment of their hands and brains? The product of slavery, intellectual or physical, can never be great.- Mark Twain
hmm my favorite quote: leave it or take it, this job is bettern then a job: The fellows who groan and sweat under the weary load of toil that they bear never can hope to do anything great!
About us |Contact us| poetry | fighting parasiteware
AIM: ssn Jason
Favorite quote: "You can do it on your own, but you don't have to do it alone"
Hmm have you seen my pic?
Similar Threads
New quote for HaikoBy FFoc in forum Midnight Cafe'Replies: 9Last Post: March 1st, 2003, 11:51 AM
quoteBy in forum Midnight Cafe'Replies: 1Last Post: July 29th, 2002, 08:33 AM


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Drag Racing Engines Brattleboro VT
Brattleboro, VT
Monday 12:00 AM - 12:00 AM
Tuesday 12:00 AM - 12:00 AM
Wednesday 12:00 AM - 12:00 AM
Thursday 12:00 AM - 12:00 AM
Friday 12:00 AM - 12:00 AM
Saturday 12:00 AM - 12:00 AM
Sunday 12:00 AM - 12:00 AM
Body Shops, Detailing, Painting, Custom Work, Paintless Dent Removal, Welding
Service Types and Repair
Auto Fiberglass, Auto Frame, Auto Glass, Auto Unibody, Collision, Dent, Fleet, Post Inspections, RV
PO Box 1786
Brattleboro, VT
Blue Seal Certified
Membership Organizations
National Institute for Automotive Service Excellence (ASE)
Dummerston, VT
Blue Seal Certified
Membership Organizations
National Institute for Automotive Service Excellence (ASE)
Townshend, VT
Auto Engines Service & Repair, Auto Service & Repair, Auto Paintless Dent Repair, Auto Inspection, Hydraulic Equipment & Supplies Dealers
Transmission Flush, Auto & Truck Repair, Air Condition Service, Tires Mounted,
Payment Options
MasterCard, Discover, VISA
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Wilmington, VT
Monday 7:00 AM - 5:00 PM
Tuesday 7:00 AM - 5:00 PM
Wednesday 7:00 AM - 5:00 PM
Thursday 7:00 AM - 5:00 PM
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Saturday Closed
Sunday Closed
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Certifications : ASE, Carquest
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Acura, Aston Martin, Audi, Auto Clutch, Auto Drivetrain, Auto Engine, Auto Interior, Auto, Bentley, BMW, Buick, Cadillac, Chevrolet, Chrysler, Classic Car, Diesel Engine, Dodge, Emergency Auto, Exotic Car, Fiat, Ford, GMC, Harley Davidson, Honda, Hyundai, Infiniti, Isuzu, Jaguar, Jeep, Kia, Land Rover, Lexus, Lincoln, Lotus, Mazda, Mercedes Benz, Mitsubishi, Motorcycle/ATV, Nissan, Oldsmobile, Pontiac, Porsche, RV/Bus, Saab, Saturn, Small Engine, Subaru, Suzuki, Toyota, Truck, Volkswagen, Volvo
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Drag Racing Engines
By Brendan Baker
From the early days of drag racing up until the recent past, racers built everything for their cars themselves, from the engines and chassis to the shop equipment. Most racing teams pulled their racecars to the track behind the family station wagon or pickup truck. The personalities who participated in the sport were as colorful as they were resourceful.


text:
MORGANTOWN, WV (AP) — West Virginia University budget administrators are considering another tuition increase for undergraduate and graduate students next fall as they wait to hear how much state funding the state's largest university and its regional campuses will lose.
The amount is currently expected to be about $13.3 million, Vice President for Administration and Finance Narvel Weese told the Board of Governors on Friday, but declining state revenues could still change that.
The extent of the cuts will be clear once the Legislature approves the new state budget, likely around April 15, he said.
If tuition rates are raised, Weese said, WVU would also raise scholarship funding to try to help keep college within financial reach of many families.
And even with another increase, he said, WVU remains among the least expensive flagship state universities in the nation.
WVU's new budget and tuition rates will be presented to the board for consideration at its June meeting in Charleston.
Last summer, the board approved a 5 percent increase in tuition. That raised the total cost from $2,837 to $3,045 per semester for residents, and from $8,922 to $9,434 for nonresident undergraduates at the main campus in Morgantown.
The board also approved a one-time fee of $63 per semester last year to replace all the individual course fees that students were once charged.
Weese said about 63 percent of WVU's budget goes toward salaries and benefits. To help control other expenses, administrators have asked all department heads to carefully review the need to fill vacancies, to travel and to replace equipment.
The larger university community has also been asked for cost-cutting suggestions.
WVU President James Clements said he wants to hear new ideas for generating revenue, too.
Copyright 2013 The Associated Press
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text: I was on YouTube earlier (it's obvious what I was searching for), and I heard this song. I can't make out much of what they're saying, but I tried looking for a couple key phrases on google and I can't seem to find it. I'm not sure of the accuracy of these though... Will my friends all argue? It makes me wonder, am I (...?) Let the smoke rise, I've got plenty (...?) Am I wasting my time, staring through the window, well it makes me wonder Is it hopeless dreaming I'm liking the Killer-esque vibe. Please help!


text:
Zoeken naar een in de bibliotheek beschikbaar exemplaar
Bibliotheken met dit item worden gezocht…
Letters (correspondence)
|Genoemd persoon:
|Thomas Herbert Johnson
|Soort document
|Alle auteurs / medewerkers:
Thomas Herbert Johnson; Bliss Perry; Joseph C Grew
|.5 linear ft.
|Meer informatie
The collection also includes two diaries, one of four months duration, when Thomas was fourteen, speaking mostly of the reading he was doing, life at school, and farm life. The other is a 1921-1922 diary, when he was teaching in the Readsboro, Vermont, schools for a few months, and ending when he was teaching in the Boston area. The diary is filled with lots of self-examination, his hopes and fears for his future, his reaction to teaching in a small rural school, including descriptions of some of his students, and ending with his arrival at Williams College and his being turned down for a fraternity.
The collection also includes letters relating to Johnson's year at Dartmouth. In one letter Thomas asks to be reinstated at Dartmouth College, where he had been asked to leave, and President Hopkins tells him why that would not be a good idea. A folder of miscellaneous letters dating from 1925 to 1933 includes a letter from Harvard's Bliss Perry and and two brief notes from George L. Kittredge.
Vergelijkbare items
- Johnson, Thomas Herbert.
- Floating University.
- Dartmouth College.
- Williams College.
- Voyages around the world -- 20th century.
- Youth -- Vermont -- Bradford -- Diaries.
- Teachers -- Vermont -- Readsboro -- Diaries.
- Bradford (Vt.) -- Archival resources.
- Readsboro (Vt.) -- Archival resources.


text:
Bantwal: Sundar Gowda (22), son of Lokayya Gowda of Kudkoli near Siddakatte in the taluk, died after his bike collided with another near his house on Sunday night.
He was on his way home from Siddakatte. Another bike, ridden by Prashant of Kukkikatte, collided with his near the Milk Cooperative society.
Sundar was thrown to the road and sustained heavy injuries. He is said to have died on the way to the hospital. Prashant was not injured.


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SEO Metrics and KPIs
A list of the key search metrics every marketing team should measure
SEO Metrics and KPIs are values used by marketing teams to measure the performance of their website for organic search results. Search engine optimization is a core function for any marketing team. In order for teams to really understand their search marketing performance, it's important to measure seo metrics and track changes month over month. This analysis can help determine top performing pages, top converting keywords, and areas of your website that need to be optimized for search.
Guide to Marketing KPIs & Metrics
Sign up and get 5 minute KPI lessons delivered to your inbox every day.
SEO Metrics and KPI Examples
Keyword Opportunity
Analyze the possibility for improvement for search rankings by comparing current rankings to Google's estimated search traffic volume and competition rating.
Keyword Click-Through Rate
Measures how often your listing on the SERP (Search Engine Results Page) generates a "click" versus the number of people performing a given search.
SEO Traffic
SEO traffic measures the number of visits to your website from organic or paid search traffic.
Content Backlog
Measure the total amount of content pieces that are waiting to be pushed live.
Average Time to New Content
Measure the duration of time between the latest published piece of content and publishing a new piece.
Landing Page Performance Optimization
Optimize your landing pages to increase conversion rate, and decrease bounce rate.
SEO Visibility
Compare this week's SEO visibility to the previous week and discover the trend.
Organic Search Traffic
The organic search traffic metric makes sure you are getting a steady stream of unique visitors from organic search.
Link Building Metrics
Link building is the process of acquiring hyperlinks from other websites to your own.
SEO Keyword Ranking
The keyword ranking metric measures your SEO keyword ranking on targeted keywords and analyzes changes in ranking over time as well as which URL is ranked for that keyword.
Domain Authority
Measures the "trust" factor related to your website based on the number of backlinks to your domain to assess the effectiveness of link-building efforts.
Track SEO Metrics on a SEO Marketing Dashboard
What is SEO?
Search Engine Optimization (SEO) is the process of increasing the visibility of a website or webpage through organic ("natural" or unpaid) search engine results. The objective of SEO is to generate content that specifically fulfills the purpose of user's online searches through tailored content that search engines recognize as quantifiably valuable.
How to track SEO performance
SEO performance is the impact of the efforts implemented to drive traffic to a webpage or website through keyword targeting, internal linking and backlinking, among many others. The end goal of generating SEO traffic is to drive customers searching for specific keywords to the specific landing page optimized to convert to sale.
The best way to measure SEO performance is through SEO metrics created through analytics. Analytics is any program that assists in gathering and analyzing data about website usage. These metrics, such as SEO keyword ranking, are hard numbers obtained from your website data gathered from analytics tools such as Google Analytics or Moz.
Simplify reporting with an SEO Dashboard Report
Tracking search metrics and KPIs allows your marketing team to analyze search engine optimization efforts. Using a dashboard to display those SEO metrics can help your team improve organic search results and increase website visits and leads.
Why should you use SEO Dashboards?
An SEO Dashboard is a one stop shop for all your web analytics data. All great digital marketers know, you can't just look at one tool to identify and fully comprehend SEO opportunities. An SEO dashboard is a central meeting place for all these data sources so that digital marketers can get a full understanding of SEO performance from a number of perspectives through metrics.
Guide to Marketing KPIs & Metrics
Sign up and get 5 minute KPI lessons delivered to your inbox every day.


text:
" Is your cervix feeling better? "
Is what I asked her this morning before she got her mandingo milk, dicked down in the shower and headed to work. She's sore and her back hurts so good but she'll be back on Tuesday when she's ready again. Ahh the life of a fashion designer is pretty colorful aye?
BobbyLongKong10, Mar 6, 2016
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text:
Lawrence "Ed" Payne, 80, of Sheffield Lake, formerly of Brookfield, Missouri, died Saturday, February 16, 2013 at Ames Family Hospice in Westlake.
He was born January 19, 1933 in Brookfield, Missouri, and was a 1952 graduate of Brookfield High School, where he lettered in football. He served with the U.S. Army during the Korean Conflict and he later attended Northeast Missouri State Teacher's College, Kirksville, Missouri.
Ed worked 40 years with Burlington Northern Railroad as an engineer and also served five years as Vice Chairman of BLE Railroad Union, retiring in 1992. While in Missouri, he was a member of V.F.W. and Masonic Lodge. He was a member of First Baptist Church in Sheffield Lake and enjoyed golfing, bicycling and photography.
Ed is survived by his wife of 25 years, Gretchen (nee Alberts); daughter, Janet (Eddie) Willet, and son, Lawrence (Elizabeth) Payne, Jr., both of Missouri; step daughter, Michele (Thomas) Reeve of Missouri; step son, Louis Dale Longbrake of Florida; nine grandchildren; and nine great grandchildren; brothers, Pastor Bernard (Sandy) Payne of Iowa, Orville Payne of California, Larry (Cathy) Payne of Missouri, Roger (Cindy) Payne of Missouri; sister, Evelyn Davis of Missouri; and several nieces and nephews.
He was preceded in death by his parents, Lawrence L. and Wilhelmina (nee Passig) Payne; son, Derald Lee Payne; step son, Kevin Longbrake; and step grandson, Jonathan Longbrake.
Dicken Funeral Home, Elyria, handled arrangements. Burial was in Knollwood Cemetery, Mayfield Heights.
Memorial contributions may be made to Alzheimer's Association, P.O. Box 74924, Cleveland, OH 44194-4924.
For online condolences, visit www.dickenfuneralhome.com


text:
0 items ·
Check out
is back-ordered. We will ship it separately in 10 to 15 days.
These treats help your small dogs clean teeth, freshen breath and remove tatar. It is a vet recommended formula and completely free of wheat, soy and corn. Contain 20 treats for small dogs (10-19 lbs).
Copyright © 2017 Capital Books and Wellness. Ecommerce Software by Shopify.


text:
tired and nothing... have desire, but...
What about after Prostate Surgery? --vardenafil?
- Asked
- 16 Jun 2011 by norwayman
- Active
- 21 Jun 2011
- Topics
- erectile dysfunction, vardenafil, surgery, prostate
Responses (2)
Discuss this with your doctor ... theoretically it's okay for you to take vardenafil after prostate surgery. But everyone's condition may be different and your doctor needs to decide that it is appropriate for you.
Levitra (vardenafil) is a phosphodiesterase inhibitor. It works by helping to relax muscles and increase blood flow into the penis during sexual stimulation. This helps men to achieve and maintain an erection.
Levitra is used to treat erectile dysfunction (impotence).
I remember my Dad having this surgery it was not easy going tor him for at least 2-3 months after he was out of the hospital, he was in his early 60's and for the first 4-5 days after surgery he had things come up and so once he started to improve he just kept slowly working his way back! you just need to give yourself some time and you may even improve faster everyone is different but I just want to wish you the very best!
Further Information
- Vardenafil Information for Consumers
- Vardenafil Information for Healthcare Professionals (includes dosage details)
- Side Effects of Vardenafil (detailed)
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
Similar Questions
I have prostate surgery about 6mn ago iam oncialis 5mg aday ihave taken it for 1 week no hard on?
Posted 3 Oct 2009 • 2 answers
JUST had a prostate radical surgery,experiencing erectile dyfunctioning viagra does not work for me?
Posted 2 Nov 2010 • 1 answer
Vardenafil - I am 58 yo. 2 years ago I had my prostate removed. I have always had premature?
Posted 6 Oct 2015 • 0 answers
I just had my prostate removed, so I'm wondering if when I get ready to have sex,will viagra help?
Posted 18 Mar 2016 • 0 answers
Erectile Dysfunction - Don't nothing make me get an erection or don't have any desire I had prostate
Posted 29 Aug 2016 • 1 answer


text: The news breaks on GraphicDesignforums first... Minuteman Press Bristol are the headline sponsors of the Bristol Design Festival 2009. Read all about it here at Bristol Design Festival. It's going to be a fantastic festival. Last year was good, this year will be superb! Come and support the events. Peter


text:
Sold listings in SoMa (2 bed) – 83/88
Sold listings in SoMa (2 bed) – 83/88
1160 Mission St #1708 San Francisco 94103
Type: Condominium
Cross Street: 8th Map: CT42
Blk/Lot/APN: 3702204 Zoning: C-3-G
Pkg: 1 N Rms: 4
~Sq Ft: Not Available $/Sqft
Year Built: 2008
Sold Date: 09/05/13
Sale Price: 1,245,000
Local Map
Directions: On North Side of Mission between 7tn and 8th.Public parking on site.
Marketing Remarks: 2BR/2BA w/ floor-to-ceiling bay windows that frame panoramic views of the San Francisco Bay and downtown. Designer upgrades include a Studio Mehler granite kitchen island with a matching sky bar" and side cabinets, eco-timber maple hardwood flooring, luxurious carpets, and custom window treatments and closets. The chef's kitchen is appointed with stainless steel Bosch appliances, Cambria quartz countertops, and Studio Becker cabinetry. The master suite includes a walk-in closet, balcony, and spa-like bathroom with dual sinks, a custom mirrored vanity cabinets with grooming lights, and the largest shower of any home at SOMA Grand.


text:
Young Living valerian essential oil (Valeriana officinalis) root has been used for thousands of years for its calming, grounding, and emotionally balancing influences. During the last three decades, it has been clinically investigated for its relaxing properties. Researchers have pinpointed the sesquiterpenes, valerenic acid, and valerone as the active constituents that exert a calming and restorative effect on the central nervous system.* German health authorities have pronounced valerian to be an effective aid for the body's needs. Valerian has an approximate ORAC of 61,935 (TE/L). TE/L is expressed as micromole Trolox equivalent per liter.
|5 ml
|Buy Now
Recent Posts
Related Posts
How To Use
For dietary or topical use. When using as a supplement, dilute one drop in 4 fl. oz. of liquid such as soy or rice milk.
Possible skin sensitivity. If pregnant or under a doctor's care, consult your physician.
Young Living blends containing valerian essential oil
- AromaSleep
- Freedom
- RutaVaLa
- SleepyIse
- T-Away
- Trauma Life
- T.R. Care
Young Living nutritional products containing valerian essential oil
* Modern scientific research has not yet validated these traditional claims. This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent disease.


text:
Prices, promotions, styles, and availability may vary. Our local stores do not honor online pricing. Prices and availability of products and services are subject to change without notice. Errors will be corrected where discovered, and Lowe's reserves the right to revoke any stated offer and to correct any errors, inaccuracies or omissions including after an order has been submitted.
Celebrate the season with these Scandinavian-inspired snowflake wall ornaments in two sizes. You can assemble in a few hours from simple materials and tools.
Missing anything? Shop Online


text:
For Q and her
Cuffs turned upward, I can see a piece of the heart. A soul painted in pixels. Stuck for freedom. The last living thing. Stuck in the weekend, we've been dancing so long. Got carried away. Spinning with arms locked tight, greedy fingers. It's almost taken me. Please. Just roll up your sleeve. Advertisements
Posted at 5:52 am on April 30, 2014 | Leave a comment | Filed Under: poem | Tagged: husband, love, marriage, poem, poetry, wife | Continue reading
Day and Night
"Don't fall asleep yet," she said. "Don't you want to talk some more?" The moon was showing in the sky as the rooster looked up at the owl. The oak tree loomed large in the evening where her eyes peered sadly back at the rooster. He hated when she did that. She was so cute […]
Posted at 1:48 pm on December 27, 2011 | Leave a comment | Filed Under: short story | Tagged: cock, day, farm, love, mouse, night, opposites attract, owl, rooster, short story | Continue reading


text:
The Paqtnkek Gas Bar has been offering full service to customers since 2005 at self-serve prices. A quick stop into or out of Paqtnkek, the station also offers convenience items to travellers, community members and guests. The Paqtnkek Gas Bar offers regular, premium and diesel fuel along with a full selection of motor oil, coolants, and other lubricants. An ATM on site also serves customers daily.
Plans for expansion of Gas Bar operations include upgrades to accommodate today's "grab and go" convenience customer are in development, offering additional employment opportunities to community members.
Hours of Operations:
Daily 7:00 am to 10:00 pm
Christina Simon Manager
Darryl McDonald, MBA email@example.com
6 Saqamaw Road
Afton Station, NS
Telephone: 902-386-2005
Fax: 902-386-2043


text:
New York University
Steinhardt School of Culture, Education, and Human Development
Graduate program in Psychology and Social Intervention
70 Washington Square South
New York City, NY 10012
United States
Program Information
Degrees Offered:
Graduate program in Psychology and Social Intervention
Format: Campus
Program Description:
The Ph.D. program in Psychology and Social Intervention prepares action scientists to transform and improve the contexts and systems in which people develop throughout their lives. The program places a strong emphasis on analysis and prevention of psychological, social, educational, and health problems, as well as on the promotion of well-being, within families, small groups, school, communities, and neighborhoods from a systems perspective, including organizational, community, and policy levels.
Working in faculty-led applied research teams and through closely supervised practica, students translate research into action by analyzing prevention and intervention programs such as those pertaining to school readiness, school success, HIV and health behaviors, mental health, housing, and homelessness. Graduates are prepared for diverse roles in academia in the areas of human development, education, public health, and public policy; for positions in policy research, advocacy, and social service organizations; and for positions that contribute to the design and implementation of evidenced-based strategies in health, education, and social services.
Accreditation:New York University is a member of the Association of American Universities and is accredited by the Middle States Association of Colleges and Schools.
Facts & Figures
Classification: Doctoral/Research University—Intensive
Locale: Large City


text:
the youtube videos?
sort by best latest
Videos can add to the quality of the hub most especially if it's related to what you're writing about. But ideally, you don't get any revenue from the videos. All revenue comes from ad clicks and impressions.
I use videos all the time though. It adds to the content. Like, I always think, if I'm surfing looking for something, there are times when I don't really want to read that much so I'd prefer watching videos sometimes. Maybe there are surfers out there who are like that. This gives them more time in your hub and spend more time looking around at links they might find interesting.
You only make money if someone clicks on the ads in your hub. The youtube videos may only add traffic if you put good captions that helps pull search traffic through keywords in the captions. So make sure you use the right keywords in your hub text and video captions.
People watching your videos does not generate any revenue for you, but it helps in making them stay on your hub longer thus the possibility of them clicking on the ads is higher.
People only receive money from YouTube videos which are featured videos on YouTube or for people who are YouTube partners... and putting those kinds of video links to a HubPage will likely cause the Hub to be unlisted as self promotional if they are your own videos.


text:
The Lava Lizard features farm to table fresh food in an open air dining room with a breathtaking view of Arenal Volcano. Wholesome meals prepared with many organic ingredients from the Leaves and Lizards farm. While you eat, enjoy a rainbow of birds visit the feeders just outside the dining area. A truly unique experience!
Lava Lizard Farm to Table Fresh Breakfast
Included with your stay. Served 7 am to 9 am. Early, To-Go or Late upon request.
Traditional Gallo Pinto (Rice & Black Beans, Cilantro, Sweet Red Peppers,
Garlic & Onions), Our Own Farm Fresh Eggs, Plantains, Fried Cheese.
Fresh Buttermilk Pancakes, Raw Cane Sugar Syrup, Eggs and Bacon
Banana Bread, Made to order Omelets (ham, sausage, cheese, onion, sweet
pepper, mushroom) and Yogurt.
Traditional Gallo Pinto, Our Own Farm Fresh Eggs, Plantains, Fried Cheese.
Fresh Buttermilk Pancakes, Raw Cane Sugar Syrup, Eggs and Bacon
Fresh Corn Tortillas with Cheese, Farm Fresh Eggs & Steve's Pork Sausage
French Toast, Raw Cane Sugar Syrup, Yogurt
Breakfast Includes:
Fresh in Season Fruit, Coffee and Tea and Fresh Fruit Juice and 'Traditional Medicinal' Juice Shot: Chan (chia)-Tamarindo-Rice/Pineapple-Flax Seed-Noni
Oatmeal, cold cereal, toast, and homemade english muffins available daily.
Lunch is available upon request.
Our local cooks prepare you a delicious traditional Costa Rica lunch.
Menu varies $12/pp
Farm to Table Fresh Dinner Selections
- Cream Cheese Rolls
- Ayote Soup
- Option 1: Chicken Breast on Grilled Chayote with Cilantro Jalapeno Sauce, Cucumber Salad & Rice. $28
- Option 2: Vegetarian Stuffed Chayote w/ Cilantro Jalapeno Sauce & Cucumber Salad $18
- Chocolate Brownie and Home Churned Coffee Ice Cream $4
- Yuca Rolls
- Savory White Bean Soup
- Option 1: Shrimp with Costa Rica Caribbean Sauce, Black Bean/Mango Salsa & Coconut Rice. $28
- Option 2: Vegetable/Chickpea Cakes with Tangy Asian Sauce, Black Bean/Mango Salsa & Coconut Rice. $19 Add Fish or Chicken Filet– $28
- Flan with Fruit Glaze $4
- Cold Rise Yeast Rolls
- Spicy Zucchini Soup
- Option 1: Pineapple glazed Pork Loin with roasted potatoes and Lemon Garlic Green Beans $29
- Option 2: Eggplant Stack with Balsamic Glaze, Rice and Lemon Garlic Green Beans $19
- Cheesecake with seasonal topping $4
- Cold Rise Yeast Rolls
- Tomato Soup
- Option 1: Orange Glazed Mahi Mahi, Seasoned Whole Grain Rice, Seasonal Vegetables with Crispy Garlic $28
- Option 2: Chef's Choice Vegetarian Recipe $19
- Grandma Darlene's Lemon Bars with Home Churned Citrus Ice Cream $4
- Yuca Rolls
- Tomato Soup
- Option 1: Stuffed Chicken Breasts served over Pasta with Lemon Grass Sauce, Cucumber Salad $29
- Option 2: Ratatouille and Cucumber Salad $19
- Ginger-Carrot Cake and Home Churned Vanilla Ice Cream $4
- Make Your Own Taco Night- Choose from all sorts of fresh ingredients to create your perfect Taco $20 (Children <12 $12)
- Traditional Tres Leches Cake $4
- Homemade Savory Focaccia Bread
- Heart of Palm Salad
- Option 1: Our Secret Recipe Homemade Beef Lasagna $29
- Option 2: Vegetarian Lasagna $19
- Passion Fruit Mousse $4
Please Note: Soups and Option 2's are Vegetarian and Gluten Free. The Yucca Rolls are "almost" Gluten Free.
Always available as dinner options: Green Salad with Chicken Breast or fish filet $18, Fruit Plate $12 and Pizza.
Lava Lizard Pizza
allow 90 min. prep time for pizza orders
Large (serves 4) $28 Medium (serves 2) $22 Single $15 (includes 2 toppings, add $4 for each additional topping)
Toppings: Cheese, Tomato, Mushrooms, Pepperoni, Sausage, Onion, Ham, Pineapple, Sweet Pepper, garlic
Children's Menu: $8
- Drumstick and French Fries
- Mini-Hamburger and French Fries
- Macaroni and Cheese and French Fries
- Grilled Cheese and French Fries
- Mini Cheese Pizza
We are happy to substitute fruit or vegetables for the fries.
Foods Organically Produced At Leaves and Lizards:
Milk, Cream, Sour Cream, Butter, Buttermilk, Cheese, A variety of fruits and vegetables, Chicken, Eggs, Beef, and Pork.
Please note:
Since all of our food is made fresh to order and the Lava Lizard is only open for our guests, reservations are required for Lunch and Dinner.
Leaves and Lizards Bar Menu
Tipping: In Costa Rica there is a mandatory service charge of 10% added to your bill, as well as 13% tax. Thanks!
*Menu is subject to change based on availability of ingredients.


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A brief, yet necessary, preamble:
So. My bad. I totally thought I wrote a review here for BREAK, Hannah's debut, which I was going to link in this review... aaaand I didn't. If you follow my blog, though, or follow me on goodreads, you already know I loved BREAK. It was a (well-deserved) 2010 ALA Popular Paperback for Teens, and I highly recommend it for reluctant readers. Easy to read and get sucked into. Quick pace and a brilliant concept. Get on it.
Now for the actual review of said novel in the post title.
Invincible Summer by Hannah Moskowitz
Young Adult Contemporary
Simon Pulse, 2011
First edition, paperback
Source: own
First, a word from Hannah. Because she highlights some things in this video that I think are important. One: this novel is difficult to summarize. And two: it's about family. No, really. It's about FAMILY. Just with some sex and the occasional F-word sprinkled in for good measure.
This is probably one of the most difficult reviews I've ever had to write. There is so much about this novel that I want to talk about, but a good majority of it will come off as spoiler-y if I get into it. Yet, at the same time, if I don't, there isn't much to say without coming off as rambly and disinteresting. (I'm getting red squiggly lines under both of those words. Whatever. You know what I mean.)
Let's start with the viewpoint character, Chase. At the beginning of the story he is 14 going on 15. At the end he is nearing his 18th birthday. So that's four years. Or rather, four summers. The presentation of the story solely through the summers spent at the family's beach house is just... amazing. The stuff that happens elsewhere really doesn't matter, and that's a difficult thing to pull off. It includes all of Chase's high school experiences, which in most YA lit is a defining quality, but not so with this novel. The definement (another red squiggly line, wtf? I swear I'm using real words) of Chase's self-perception comes through his summer experiences.
Hence the title, Invincible Summer. It's perfect. Also perfect? Is the cover. This story is told through summers, and I believe the cover presents summer in all its wondrous glory. It's clean and bright. It gets up close and personal with a hot chick in a bikini. That's summer, yes? But for some reason it has been the source of much debate among book bloggers and readers. So there's a girl in a bikini on the cover. Everyone assumes, then, that the love interest (or rather, the sex interest) is the main plot. It SO isn't. The disaster that is Melinda certainly has influence on the events of the story and the realizations of the MC about life--his life--but she, herself, is not the plot. The fact that Chase and his older brother Noah are both "involved" with her is NOT the plot. It's just one element of a much bigger concept.
And that concept is -- family relationships. In my goodreads review I mentioned that this novel is just as much Noah's story as it is Chase's. The perception of Noah through Chase's eyes is yet another item that goes under the "reasons why this book is brilliant" column. Chase calls him "my brother the flight risk", and if that isn't enough to get you interested in the relationship between these two brothers, then maybe this will be: they're both doing the girl next door, and they both know they're both doing the girl next door, and they both continue doing the girl next door in light of this knowledge. It's all very weird and gritty and makes you want to powerwash your brain. Or dry heave. Sorry, but I had a hard time stomaching the idea of so obviously sharing a girl. This didn't stop me from reading, though, and I still love the book enough to recommend it.
But again, that is just one element of the big picture.
Noah is a huge part of the story. He has real issues. Issues I can relate to, and I think that's why I fell for him so hard while reading this. We also have Chase's younger brother, Gideon. Oh God... where do I even start with Gideon. Well, he's only six years old at the beginning. And he's deaf. And stinking adorable. And wildly intelligent. I can't even... seriously, I can't even talk about Gideon without getting teary-eyed. How Hannah managed to portray such a deeply layered character through the eyes of someone else still has me reeling.
Then there's Claudia, Chase's younger sister, who is eleven years old at the beginning. She is, in a word, adventurous. Totally love her. The parents? Mom is pregnant during the first summer. So, another kid is added to this already large family. You'd think the parents just can't get enough of each other, right? Wrong. Hannah added huge parental issues to the mix. Again, brilliant.
The story is just one dynamite layer after another after another after another... until it all explodes.
I can't get into the minor issue I had with the ending without giving anything away, so I'll add one final remark on the Melinda thing. She was raped when she went to college -- I don't think saying that here will ruin your enjoyment of the book. It's made pretty obvious early on in the story.
The thing I want to comment on is that even though she was raped, and subsequently fell into a depression (which is expected), she didn't shy away from sex after that horrible experience. To me, this came across as REALISTIC. Yes, many girls who are raped can't stand the thought of going near a guy for a long, long time, after much, much therapy. But. That isn't always the case. Some girls then use sex as a way of staying in control. They had an "out of control" sexual experience, so they put themselves in situations where they are "in control of" the sexual experience. And that's exactly what Melinda does with Noah and Chase.
And I just want to personally thank Hannah for going that route, when most novels that include this touchy subject go the obvious route of the girl completely withdrawing from all forms of sex. It was refreshing to see something different, yet still real.
Okay, I think I've blabbered on long enough (no red squiggly line under "blabbered"? I give up). All that's left to say is READ THIS BOOK. 4 out of 5 stars.
Sunday, May 29, 2011
INVINCIBLE SUMMER by Hannah Moskowitz
Posted by Lydia Sharp at 12:11 PM
Labels: *very good, *young adult, Hannah Moskowitz, Invincible Summer
2 comments:
- Claire Dawn said...
I've been seeing this in your blog sidebar and have it TBRed forever. Must read. Summer's on the way. :)
- May 30, 2011 at 9:21 AM
- The Tame Lion said...
Good, very good.
- June 3, 2011 at 1:54 PM
Subscribe to: Post Comments (Atom)


text:
Migrant workers die in fire at poor house in Saudi Arabia
Eleven migrant workers have suffocated as a fire engulfed a windowless house they shared in Saudi Arabia.
"Firefighters put out a blaze in an old house lacking windows for ventilation," the civil defense stated in a message posted on Twitter on Wednesday.
"Eleven people died of asphyxiation" in the southern province of Najran, it added.
The blaze also left six workers injured.
According to the report, the victims were Indian and Bangladeshi nationals.
Millions of poor Asians are working in the Persian Gulf states. Human rights groups say many of the workers suffer exploitation and abuses, including non-payment of wages.
According to latest official figures released in 2015, there are nine million foreigners currently working in Saudi Arabia, many of them South Asians.
Rights groups have urged the Persian Gulf kingdom and other Arab states to end the "kafala" sponsorship system, which forces foreign workers to seek their employer's consent to change jobs or leave the country, a measure rights groups say leaves workers open to exploitation.


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Anne of Green Gables the Continuing Story / a Kevin Sullivan production ; producers, Trudy Grant, Kevin Sullivan ; writters, Kevin Sullivan, Laurie Pearson ; director, Stefan Scaini.
Available copies
- 1 of 1 copy available at Evergreen Indiana.
Current holds
0 current holds with 1 total copy.
View other formats and editions
|Call Number / Copy Notes
|Shelving Location
|Due Date
|Garrett PL - Garrett
|DVD ANN (Text)
Record details
- Physical Description: 1 videodisc (approximately 185 min.) : sound, color ; 4 3/4 in.
- Publisher: [Canada] : Sullivan Entertainment, [2002]
- Copyright: ©2002
Content descriptions
|General Note:
| Based on the novels by Lucy Maud Montgomery.
Videodisc release of the 2000 television motion picture.
Digitally restored 2001.
|Creation/Production Credits Note:
| Director of photography, Robert Saad ; editor, Mairin Wilkinson ; original music, Peter Breiner ; costume designer, Ruth Secord ; production designer, Arthur Herriott.
|Participant or Performer Note:
| Megan Follows, Jonathan Crombie, Cameron Daddo, Schuyler Grant, Patricia Hamilton, Rosemary Radcliffe, Miranda de Pencier, Janet-Laine Green, Martha Henry.
|Summary, etc.:
| Now in her twenties, Anne returns to Avonlea for the first time since Marilla's death. Gilbert is offered a position in New York and he convinces Anne to go with him. Big city life isn't what they expected. After her script is stolen, they travel from New York to the war effort in Europe and they eventually return to Prince Edward Island.
|Target Audience Note:
| MPAA rating: Not rated.
|Additional Physical Form available Note:
| Also issued on VHS.
|System Details Note:
Search for related items by subject
|Man-woman relationships > Drama.
Manuscripts > Drama.
Prince Edward Islands > Drama.
|Television mini-series.
Made-for-TV movies.
Feature films.
Film adaptations.


text:
Panthers down DL icemen in regular season finale
The Detroit Lakes boys' hockey team was one win away from sharing a piece of the Mid-State Conference title Thursday, but the visiting Park Rapids Panthers denied them that honor with a 3-1 victory in the regular season finale.
The Lakers (10-15) instead dropped to fourth place in the conference with a mark of 4-4, while the Panthers (13-12) clinched the title outright with a 6-2 record.
Two goals in the first period by Park Rapids were followed by another tally in the second, as Panther goalie Cody Brumbaugh had 26 saves in the victory.
The Lakers were outshot 10-5 in the first period, but controlled the puck in the final two periods by outshooting the visitors by a 22-14 margin.
But DL couldn't find the back of the net until 5:58 into the third, when Austin Rusness took a nice pass from YouTube sensation, senior Alex Mason, while Connor Collins also gained an assist.
The Lakers even had a two-man advantage in the second period, but failed to produce any points to go 0-for-4 on power play opportunities.
Jamie Stewart opened the scoring on a power play goal 6:16 into the first, while forward Sam Coburn weaved his way through the Laker defense to create a nice breakaway short-handed goal to put Park Rapids up 2-0.
Cory Odland added the Panthers' third goal four minutes into the second period.
Laker goalie MacKenzie Steele still had a solid game with 21 saves.
The Lakers were awarded the sixth seed in the upcoming Section 8-1A playoffs and will have the tough task of playing No. 3 Warroad (13-11-1) on their home ice Friday, starting at 8:15 p.m.
Laker results
Park Rapids at Detroit Lakes, Thursday, Feb. 16.
Panthers 2 1 0 - 3
Lakers 0 0 1 - 1
1st Period -- Scoring: P RPDS - Stewart Goal (PP) (Johnson, Erickson) 6:16. P RPDS - Coburn Goal (SH) (Johnson) 14:02. Penalties: Brekke, DTRTLK (Cross-Checking, Minor, 2 min) 5:59. Rusness, DTRTLK (Slashing, Minor, 2 min) 6:28. Fritz, DTRTLK (Interference, Minor, 2 min) 7:21. Mueller, P RPDS (Holding, Minor, 2 min) 13:02.
2nd Period -- Scoring: P RPDS - Odland Goal (Moren) 4:00. Penalties: Erickson, P RPDS (Hooking, Minor, 2 min) 4:25. Brekke, DTRTLK (Hooking, Minor, 2 min) 5:47. Macpherson, P RPDS (Illegal Check to the Head, Major, 5 min) 9:43. Erickson, P RPDS (Interference, Minor, 2 min) 15:41.
3rd Period -- Scoring: DTRTLK - Rusness Goal (Mason, Collins) 5:58. Penalties: Herrmann, DTRTLK (Hooking, Minor, 2 min) 12:08. Rusness, DTRTLK (Slashing, Minor, 2 min) 15:58.
Shots on goal -- DL 5 11 11 - 27...PR 10 6 8 - 24.
Saves -- DL (MacKenzie Steele) 21...PR (Cody Brumbaugh) 26.


text:
Medical marijuana is helping some patients to find relief from pain, nausea, loss of appetite, and neurological spasms. Because of its' reported benefit to certain patients with cancer, AIDS, medical sclerosis, glaucoma, and other chronic conditions, medical marijuana is slowly gaining acceptance in the community. Since 1998, sixteen states and DC have enacted legislation to legalize the medical use of marijuana.
It is not without risk. Most states have not yet chosen to legalize cannabis for medical use. A look at the long term health considerations may shed light on the controversy.
Cannabis and Cancer
A PBS documentary recently discussed the work of Dr. Prakash Nagarkatti, who has had some success killing cancer cells in a test tube, using cannabis synthesized in the lab. In addition, recent research in Spain suggests that THC found in marijuana was an active agent in killing brain cancer cells, while sparing cells that did not have cancer. This all appears to be promising news. However, THC is also strongly linked to respiratory cancers, and cancers of the head and neck! Figures vary somewhat, but studies show that around 5 joints a day irritate the lungs to the same degree as a full pack of cigarettes. It is well established that chronic lung irritation leads to many types of respiratory distress and illness, including bronchitis and cancer.
Marijuana is especially irritating to the throat and lungs, because it is deeply inhaled. Marijuana, like cigarettes, contains tar and even many more carcinogens. None of the carcinogens are filtered when smoking marijuana. This is likely the reason that smoking marijuana is associated with cancer of the pharynx and larynx. It is likely associated with lung cancer also, especially in long term users and those who smoke both tobacco and marijuana.
In addition to cancers of the head and neck and some cases of lung cancer, marijuana has been linked to certain reproductive cancers in both sexes. These include cancers of the prostrate and cervix. Numerous studies, such as one performed at the Fred Hutchinson Cancer Research Center, provide convincing evidence that marijuana may trigger an aggressive form of testicular cancer known as nonseminoma testicular cancer.
Testicular cancer is primarily diagnosed in young men in their twenties. Young men who were regular marijuana smokers before the age of 18 have almost double the risk! It is believed that marijuana has an influence on the hormone testosterone.
This would be suggested in part by the observation that adolescent male marijuana smokers may develop enlarged breasts. Smoking marijuana also is linked to inadequate sperm and impotence in habitual users. There appears to be a synergistic interplay between the hormones of puberty, marijuana smoking, and the development of testicular cancer. Even when other potential risk factors are controlled, young men who smoke marijuana have an exponential risk.
Cannabis and Immune System
Besides the irritating effect of marijuana smoke on the airways, respiratory illness may also be increased because of depressed immunity. Some studies have suggested that the T cell function is compromised in the lungs of marijuana smokers. Physicians and medical centers treat coughs and bronchitis in many patients who smoke medical marijuana.
At least one study also showed that medical marijuana may interfere with the maturation of monocytes, a subtype of white blood cells. White blood cells are what the body uses to launch an attack against aggressive viruses and bacteria which cause various illnesses. The degree of immunosuppression caused by medical marijuana is controversial. However the significance may lie in the fact that any degree of immunity suppression may be especially harmful in a sick patient who cannot fight off infection normally.
Some users of medical marijuana certainly fall into this category, such as patients with AIDS. Multiple sclerosis has been linked to the Epstein Barr virus, and even some cancers may be discovered to have a viral link.
Cannabis and the Heart
Researchers have learned that the heart responds very quickly to cannabis use. The pulse increases and blood pressure drops almost immediately after use. These side effects have caused researchers to conclude that medical marijuana elevates heart attack risk.
There are many risk factors associated with the occurrence of heart attack, and the effects of medical marijuana would be an added risk. Certainly this would be of more significance in a patient who has multiple prior risk factors for heart disease.
Cannabis and the Mind
The effects of mental relaxation make medical marijuana useful in pain management. Indeed, pain management is one of the most common uses of cannabis.
There are other intriguing studies and anecdotal testimonials which indicate that medical marijuana may have positive mental effects in certain persons. A few parents are claiming that medical marijuana has made a world of difference in their autistic children, primarily due to its' calming effect on an excitable brain. There is even a study at the Snipps Research Institute which suggests marijuana may discourage the formation of Alzheimer plaques.
Casual users of marijuana are well aware of its' effects on the mind. It is called "dope" on the streets because it appears to generally slow cognitive processes. There have been a few studies that suggest IQ is compromised in young , habitual smokers of marijuana.
However, marijuana can also trigger the altered mental states of paranoia, delusions, and hallucinations. Some patients who have terminal illness may perceive this to be more detrimental than the symptoms being treated by medical marijuana. It can be presumed that many such patients nearing the end of life would want to have a clear mind to experience it.
The altered mental states associated with marijuana may also put severely debilitated patients receiving it at significantly elevated risk for an accident. Medical marijuana is reported second only to alcohol found in the bloodstream after an accident. It is easy to see the dangers of driving a car, or even taking a bath while under the influence of delusions or hallucinations.
Hanging in the Balance
Medical marijuana remains engaged in a heated battle for widespread acceptance in the community. That's because it's complicated! Research is really in its' infancy, and results are sometimes contradictory.
Doctors prescribing medical marijuana, and patients considering using it, must weigh the individual's medical condition, degree of suffering, and availability of alternative treatments, against identifiable risks. They must also stay abreast of ongoing research.
One thing is certain. Medical marijuana is not an inert substance. It is a complex pharmaceutical containing over 300 substances! Much further research is needed into the long term and synergistic effects of these chemicals on the human body.
"Clearing the Smoke," PBS Documentary; Western Journal of Medicine; Cancer Journal; Merck Manual; Health Day News; About.Com Lung Cancer


text:
The "IPA Lifetime Achievement Award" has as a goal to acknowledge the lifetime contribution of individuals for outstanding permafrost science and engineering research. and/or for exceptional contributions to the international permafrost research community.
The first of these awards was made during the European Conference on Permafrost (EUCOP III) in June 2010. The second was awarded during the Tenth International Conference on Permafrost (TICOP) in June 2012. The third was awarded during the Fourth European Conference on Permafrost (EUCOP4) in June 2014, and the fourth was awarded in June 2016 during the 11th International Conference on Permafrost (ICOP 2016) in Potsdam, Germany.
The nomination process for the award have to be supported by a citation and letters of support. The nominations are made directly by the IPA member countries and need to be supported by at least three individuals from three different countries. If you are interested in nominating an individual, please contact the relevant country representative and use the nomination form to prepare your nomination.
IPA Lifetime Achievement Award 2016
The recipient of the IPA Lifetime Achievement Award 2016 is Prof. Hugh French (shown receiving his award from Antoni Lewkowicz, IPA President 2012-2016).
IPA Lifetime Achievement Award 2014
The recipient of the IPA Lifetime Achievement Award 2014 is Prof. Cheng Guodong.
IPA Lifetime Achievement Award 2012
The recipient of the IPA Lifetime Achivement Award 2012 is Prof. Nikolai. N. Romanovskii.
IPA Lifetime Achievement Award 2010
The recipient of the IPA Lifetime Achivement Award 2010 is Prof. J. Ross Mackay.


text:
London, United Kingdom (PressExposure) October 20, 2008 -- Hundreds of thousands of people have lost their jobs around the world in the past few months, with economists predicting that this trend is set to continue for some time. The impact of the global credit crunch has led some people to consider being their own boss and thus, starting an online business.
However, one of the biggest hurdles they face is a lack of technical awareness of computer languages normally needed to build a website, including HTML, CSS and PHP.
This needn't be a problem, says Seltzer Cole, founder of Newlaunch.net: "Advances in software development mean that today, someone with no knowledge of web design software can build their own all-singing, all-dancing website in just a few minutes."
He added: "At Newlaunch.net, we provide a range of services allowing anyone to get online in a very short time. Someone can design their own site for free with adverts or choose a paid-for package from less than $10 a month or $80 a year, with a domain name, up to five websites, dozens of templates, an image gallery, video jukebox, MP3 player, forum, live chat and hundreds of widgets. They can also make money from their site using Google Adsense.
There's absolutely no reason why someone who wants to start their own business can't get online today!"


text:
Freight rates for Very Large Crude Carriers in the East of Suez have ebbed to this year's low. But the situation is not as bad as it could have been, as associate editor Wanda Wang explains in this video. More ton mile demand is anticipated as Asian refiners look farther afield to quench their thirst for crude oil. Is this enough to keep the freight market afloat?
More shipping news and analysis: http://plts.co/kj7t309ZkYA
Continue reading at S&P Global Platts (via YouTube) →


text:
MyEssayWriting.com - Essay Writing Services.
Most children aren't familiar with the name Theodor Geisel, but they've certainly read his books. Using the pen name Dr. Seuss, Geisel's books, including 'The Cat in the Hat' and 'How the Grinch Stole Christmas', are synonymous with children's literature. Learn more about the author who helped teach most of us how to read.Reading Level: Grades 6-12CONTENTS1 To Think That It Happened on Madison Avenue2 Dr. Seuss Learns His ABCs3 The Grad Becomes an Ad Man4 Dr. Seuss Hears a "Yes"5 Dr. Seuss Signs Up6 New Dreams - and One Bad Nightmare7 Busy, Busy Dr. Seuss8 "We Can Do Better Than This"EpilogueChronologyMost Popular BooksWorks By The AuthorBest Known CharactersMajor AwardsSources UsedWeb SitesIndexPicture CreditsAbout the Author


text:
About the Book
In Roll Me Up and Smoke Me When I Die, Willie Nelson muses about his greatest influences and the things that are most important to him, and celebrates the family, friends, and colleagues who have blessed his remarkable journey. Willie riffs on everything, from music to poker, Texas to Nashville, and more. He shares the outlaw wisdom he has acquired over the course of eight decades, along with favorite jokes and insights from family, bandmates, and close friends. Rare family pictures, beautiful artwork created by his son, Micah Nelson, and lyrics to classic songs punctuate these charming and poignant memories.
A road journal written in Willie Nelson's inimitable, homespun voice and a fitting tribute to America's greatest traveling bard, Roll Me Up and Smoke Me When I Die—introduced by another favorite son of Texas, Kinky Friedman—is a deeply personal look into the heart and soul of a unique man and one of the greatest artists of our time, a songwriter and performer whose legacy will endure for generations to come.
Educator and Librarian Resources
Audio Excerpt
To view this page ensure that Adobe Flash Player version 10.0.0 or greater is installed.
Product Details
- Imprint: HarperAudio
- On Sale: 11/13/2012
- List Price: 15.99 USD
- BISAC1: BIOGRAPHY & AUTOBIOGRAPHY / Composers & Musicians
- BISAC2: BIOGRAPHY & AUTOBIOGRAPHY / Entertainment & Performing Arts
- BISAC3: BIOGRAPHY & AUTOBIOGRAPHY / Personal Memoirs


text:
RenaSci Consultancy
RenaSci Consultancy
Lynch C.J.,Pennsylvania State University |
Zhou Q.,Oregon Health And Science University |
Shyng S.-L.,Oregon Health And Science University |
Heal D.J.,RenaSci Consultancy |
And 9 more authors.
American Journal of Physiology - Endocrinology and Metabolism | Year: 2012
Here, we examined the chronic effects of two cannabinoid receptor-1 (CB1) inverse agonists, rimonabant and ibipinabant, in hyperinsulinemic Zucker rats to determine their chronic effects on insulinemia. Rimonabant and ibipinabant (10 mg·kg -1·day -1) elicited body weightindependent improvements in insulinemia and glycemia during 10 wk of chronic treatment. To elucidate the mechanism of insulin lowering, acute in vivo and in vitro studies were then performed. Surprisingly, chronic treatment was not required for insulin lowering. In acute in vivo and in vitro studies, the CB1 inverse agonists exhibited acute K channel opener (KCO; e.g., diazoxide and NN414)-like effects on glucose tolerance and glucose-stimulated insulin secretion (GSIS) with approximately fivefold better potency than diazoxide. Followup studies implied that these effects were inconsistent with a CB1- mediated mechanism. Thus effects of several CB1 agonists, inverse agonists, and distomers during GTTs or GSIS studies using perifused rat islets were unpredictable from their known CB1 activities. In vivo rimonabant and ibipinabant caused glucose intolerance in CB1 but not SUR1-KO mice. Electrophysiological studies indicated that, compared with diazoxide, 3 μM rimonabant and ibipinabant are partial agonists for K channel opening. Partial agonism was consistent with data from radioligand binding assays designed to detect SUR1 K ATP KCOs where rimonabant and ibipinabant allosterically regulated 3Hglibenclamide- specific binding in the presence of MgATP, as did diazoxide and NN414. Our findings indicate that some CB1 ligands may directly bind and allosterically regulate Kir6.2/SUR1 K ATP channels like other KCOs. This mechanism appears to be compatible with and may contribute to their acute and chronic effects on GSIS and insulinemia. © 2012 the American Physiological Society.
Poucher S.M.,Astrazeneca |
Cheetham S.,RenaSci Consultancy |
Francis J.,Astrazeneca |
Zinker B.,Bristol Myers Squibb |
And 2 more authors.
Diabetes, Obesity and Metabolism | Year: 2012
Aims: We examined the effects of the oral dipeptidyl peptidase-4 (DPP-4) inhibitor saxagliptin on glycaemic control and pancreatic β-cell mass and morphology in a mouse model of type 2 diabetes mellitus (T2DM). Methods: Male C57BL/6 mice (n=12/group) aged 4 to 6weeks and weighing >15g received a high-fat diet throughout this 45-day study. After a 7-day handling period, baseline levels of plasma glucose, plasma insulin and glycated haemoglobin (HbA1c) were assessed. Animals were allocated to one of six groups: compound vehicle control, intraperitoneal streptozotocin (STZ, 50mg/kg)-treated control and saxagliptin (10mg/kg) or sitagliptin (10mg/kg, positive control) initiated 7days before or 1day after STZ administration. Endpoints included changes in body weight, food and water consumption, glucose tolerance (approximately 3 weeks post-STZ), fasting glucose and HbA1c and immunohistochemical analyses of the pancreas. Results: Body weight, weight gain and food intake were reduced in STZ versus control mice. DPP-4 inhibitor treatment did not affect these changes, but the increase in water intake observed post-STZ administration was significantly attenuated with DPP-4 inhibitors whether initiated before or after STZ injury. Small but significant improvements in glycaemic control were observed with DPP-4 inhibitors versus the STZ control. Improved β-cell mass and morphology were observed with saxagliptin given pre- or post-STZ and sitagliptin given post-STZ. Conclusions: Saxagliptin mitigated damage to β-cells and improved glycaemic control in this mouse model of T2DM. © 2012 Blackwell Publishing Ltd.


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