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Traveling Luck for Stony Craft Golf Course, Michigan, United States
Where is Stony Craft Golf Course?What's around Stony Craft Golf Course?
Wikipedia near Stony Craft Golf Course
Where to stay near Stony Craft Golf Course
The timezone in Stony Craft Golf Course is America/Iqaluit
Sunrise at 08:35 and Sunset at 18:03. It's light
Latitude. 42.5897°, Longitude. -83.2403°
Weather near Stony Craft Golf Course; Report from Troy, Oakland/Troy Airport, MI 9km away
Weather :
Temperature: 12°C / 54°F
Wind: 11.5km/h South/Southwest gusting to 17.3km/h
Cloud: Sky Clear
Weather :
Temperature: 12°C / 54°F
Wind: 11.5km/h South/Southwest gusting to 17.3km/h
Cloud: Sky Clear
Satellite map around Stony Craft Golf Course
Loading map of Stony Craft Golf Course and it's surroudings
Geographic features & Photographs around Stony Craft Golf Course, in Michigan, United States
- school;
- building(s) where instruction in one or more branches of knowledge takes place.
- Roeper School (1.2km)
- East Hills Junior High School (1.2km)
- Elizabeth Taylor Traub School (2.2km)
- Vaughn School (2.3km)
- Kingswood School (2.3km)
- Bloomfield School (2.4km)
- Lahser High School (2.6km)
- Eastover School (2.7km)
- Brookside School (2.9km)
- Hickory Grove School (3km)
- Cranbrook School (3.1km)
- Way School (3.6km)
- Harlan School (4.1km)
- Covington Junior High School (4.2km)
- Quarton School (5km)
- Avondale Junior High School (5.3km)
- Franklin School (5.3km)
- Holy Name School (5.4km)
- Stone School (5.5km)
- Wilson School (5.6km)
- Whittier School (5.8km)
- Sacred Heart School (6km)
- Frost School (6km)
- lake;
- a large inland body of standing water.
- Vhay Lake (0.8km)
- Cranbrook Lake (2.5km)
- Orange Lake (3.1km)
- Hadsells Pond (4.2km)
- Lower Long Lake (5.2km)
- Minnow Lake (5.3km)
- Gilbert Lake (5.5km)
- Forest Lake (5.9km)
- Island Lake (5.9km)
- church;
- a building for public Christian worship.
- Saint Hugo Church (0.9km)
- Birmingham Church (2.9km)
- Incarnate Word Church (2.9km)
- Beautiful Savior Church (3.2km)
- Saint Stephens Church (3.3km)
- Fellowship Church (5.5km)
- Northminster Church (5.6km)
- park;
- an area, often of forested land, maintained as a place of beauty, or for recreation.
- Springdale Park (4.4km)
- Murphy Park (5.3km)
- Manor Park (5.3km)
- Poppleton Park (5.6km)
- Booth Park (5.8km)
- Local Feature;
- A Nearby feature worthy of being marked on a map..
- Stony Craft Golf Course (0km)
- Bloomfield Hills Country Club (1.5km)
- Forest Lake Golf Course (5.8km)
- Church of the Master (6km)
Accommodation around Stony Craft Golf Course
- populated place;
- a city, town, village, or other agglomeration of buildings where people live and work.
- Bloomfield Hills (1km)
- Charing Cross (3km)
- Oak Grove (4km)
- tower;
- a high conspicuous structure, typically much higher than its diameter.
- WBFH-FM (Bloomfield Hills) (4.7km)
- WAHS-FM (Auburn Heights) (5.1km)
- WPON-AM (Pontiac) (5.4km)
- administrative division;
- an administrative division of a country, undifferentiated as to administrative level.
- Bloomfield Hills, City of (1.6km)
- Bloomfield, Township of (3.6km)
- cemetery;
- a burial place or ground.
- Beach Cemetery (4.1km)
- Greenwood Cemetery (5km)
- reservoir(s);
- an artificial pond or lake.
- Endicott Lake (3.6km)
- stream;
- a body of running water moving to a lower level in a channel on land.
- Amy Drain (1.1km)
- hospital;
- a building in which sick or injured, especially those confined to bed, are medically treated.
- Saint Joseph Hospital (4.9km)
Wikipedia entries close to
Stony Craft Golf Course
- Bloomfield Township city city h
- Pontiac Assembly Center landmark landmark
- Avondale High School (Auburn Hills) landmark education
- Birmingham (Michigan) city city i
- Somerset Collection
- Pontiac Silverdome landmark sport
- Pontiac (Michigan) city city g
- Oakland-Troy Airport airport airport
- Top of Troy tower
- Beverly Hills, Michigan city o
- Troy (Michigan) city city f
- Groves High School (Michigan) landmark education
- Franklin Cider Mill science
- Royal Oak High School landmark education
- Clawson, Michigan city o
- Rochester Hills, Michigan city o
Airports close to Stony Craft Golf Course
Detroit city(DET), Detroit, Usa (32.7km)
Selfridge angb(MTC), Mount clemens, Usa (39.9km)
Windsor(YQG), Windsor, Canada (49.9km)
Detroit metro wayne co(DTW), Detroit, Usa (51km)
Willow run(YIP), Detroit, Usa (54.4km)


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A big corruption case in Brazil is raising the profile of the justice system – and respect for the rule of law
The 1980s was a lost decade for Brazil and several other Latin American countries. It was a period of high unemployment, the IMF code of conduct, fiscal austerity, recession and public demonstrations. Sound familiar?
Since then, we have seen several changes: inflation under control, fiscal balance, large-scale privatisation and a new constitution.
More recently, the country became the first letter of the famous Brics and has improved income distribution, meaning more consumers and a larger middle class. All these changes have had a profound effect in the legal profession.
Brazil keeps struggling to find its own way to modernise and grow into a larger role in the world, more compatible with the size of its territory and GNP – respectively, the world's 5th and 6th largest.
Now, the country is following closely the judgment in a case concerning Mensalão ('large monthly allowance') at its Supreme Federal Court. Mensalão is the nickname of a scheme whereby the ruling party gave money to congressmen to attract support for its political agenda – an 'acquired' political alliance using public funds.
The matters took place during the first term of the still popular former president Lula and involved the former chief of staff, the former president of the Workers Party, the president of Congress and the senior officers of a bank among others. All have been found guilty.
The judgment began three months ago and is expected to last until the end of the year. It is shown on TV and some cable networks show whole sessions live. There are three sessions each week.
Some of the mystery surrounding the judiciary is being dissipated by this process. Most everyone now has an opinion about the case and the justices involved. Commentators explain the law and procedures, as well as possible outcomes.
The judiciary has shown its independence and the population has shown its appreciation and support for the rule of the law.
It is important to note that Brazil is holding elections for mayors and city councils as the case reaches its climax. The results of these are important for the 2014 presidential election. The judgment is about campaign financing, corruption, banking regulation, embezzlement of public funds, money laundering and tax evasion – hot topics anywhere these days.
The Supreme Court is sending strong messages on all these matters. The new jurisprudence follows modern trends and enjoys wide support among the public. This is part of a silent revolution that is transforming the justice system in the country.
It is also an important display of the freedom of the press and the benefits of this. The press has played an important part in making the scheme public and showing Brazilians the importance of the rule of law and the role of the court.
Of course, all this will have a big impact on the legal community as the country develops.

subset: commoncrawl


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Denied my dream air hostess job - all because I used to be depressed, says angry applicant
A YOUNG woman was turned down for her dream job as an air hostess after she revealed she used to suffer from depression.
Megan Cox, 22, was offered a role with Dubai-based airline Emirates last month. But the offer was withdrawn when she provided her medical history.
Her notes showed she had suffered from depression twice in the past following "traumatic events".
Megan, who was left £1,000 out of pocket by the application process, has now set up a page on Facebook bravely outlining the "cruel" situation.
Called Emirates Against Depression, she writes: "In April I was offered my dream job with Emirates after the incredibly tough open day and final interview.
"One week after I was offered the job as a cabin crew member I was given a ridiculous medical. As part of the medical I needed to agree for Emirates to view all of my medical history.
"I have suffered twice with depression, once in 2009 and again in 2012, after horrific and traumatic events."
In April I was offered my dream job with Emirates after the incredibly tough open day and final interview.
Her doctor provided a note explaining that she had recovered and was no longer on any medication, but to no avail.
Megan, of Bridgwater, Somerset, said: "I feel completely discriminated against.
"I was given every indication that I was going to get the job and to have it snatched away from me like this because of something in the past is so cruel.
"I didn't receive any further feedback about why I had been rejected by Emirates. I think it is terrible and I want to help others look out for this."
Megan, who now works in administration at Exeter Hospital, added: "Depression made me a stronger person and opened my eyes to the world. I would have been the perfect air hostess."
Experts say that withdrawing a job offer because the applicant used to have depression can be illegal if a court judges the condition to be a disability.
However, Emirates may not be covered by UK employment law because it is a Dubai company.
Marjorie Wallace, of mental health charity SANE, said: "People can recover from depression as they do from any physical illness, therefore it is wrong they should be discriminated against."
An Emirates spokesman said they would refund all Ms Cox's pre-employment related medical expenses.


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They wouldn't be gaining, or losing, many daylight hours by observing the clock change. But the time change was repealed after each war, leaving mass confusion because each city adopted its own ordinances. Daylight Saving Time was an idea conceived by Benjamin Franklin in 1784. Like it or not, it's time to spring forward. And for Wilson, her best advice is to do not forget to change the clock.
And he advises having your family practice that escape plan twice in the year - once in daylight and once a night. The U.S. Department of Transportation says yes because a study shows that it cuts electricity usage by 1 percent. "Daylight saving time" is correct; "daylight savings time" is incorrect. Daylight-saving time is a hot topic on Twitter , with people expressing both enthusiasm and disdain for the impending loss of sleep.
A USA citizen arriving at JFK from Santo Domingo Dominican Republic last week was literally " bursting out of his pants " when he went through Customs. "Fortunately this is not the first time U.S. Customs and Border Protection officers in NY have seen this concealment method", the agency stated. He faces federal narcotics smuggling charges.
The Florida woman who was dubbed by cable TV-show hosts as "the most hated mom in America" after she was accused of killing her toddler says she still doesn't know how the last hours of her daughter's life unfolded. In a separate interview, the judge who presided over Casey Anthony's murder trial says the Florida mother may have killed her 2-year-old daughter by accident.
The idea of daylight saving was the brainchild of Benjamin Franklin, aka, the "early to bed, early to rise" guy, back in 1784. Sunday brings the annual switch to Daylight-Saving Time - a time for saving daylight and losing an hour of sleep.
Andy Billig, D-Spokane, one of Senate Democrats' leaders on education issues. While Gov. Susana Martinez has vowed to veto any tax increases approved by the Legislature, the Martinez administration has indicated the governor is open to closing tax "loopholes".
The 14-time major winner's injury woes are ongoing, back spasms leading to his withdrawal from his last tournament - the Dubai Desert Classic in early February. Woods then missed both the Genesis Open and Honda Classic - his next planned starts - and cancelled a planned press conference at Genesis after his doctors advised him to "limit all activities".
Northwest wind 5 to 10 miles per hour. Forecasters at The Weather Channel are now predicting 5-8 inches of snow for the Harrisburg area on Tuesday during the day, then another 1-3 inches of snow in the evening. Tuesday: Mostly cloudy, with a high near 52. Chance of precipitation is 90%. Wednesday , Partly sunny, with a highs into the upper 50's and lower 60's.
Luckily, she said, Madison wasn't hurt. The 4-year-old holds onto the front door as winds send it blowing open. Thousands are still without power and we've seen a lot of property damage. In the background, Gardner does not seem to notice Madison's predicament as she rummages through the family SUV and helps her other daughter out of the vehicle.
The National Weather Service has issued a Winter Weather Advisory with a forecast of snow starting around midnight and continuing throughout the day tomorrow. With a low of 21 degrees overnight, icy conditions are possible. As much as 15 inches may fall in the Finger Lakes during the same time, the service is predicting.
He has been around her family and she really likes that he is a dad". When Cohen asked Lopez if she'd date a man who couldn't dance and had no rhythm, she mused after a long pause, "Yeah". So where does Lopez's alleged blossoming romance with Rodriguez leave Drake? The the emcee said that if Ray made a decision to plead the fifth to a question, he would lob one at Jennifer that she would have to answer instead.
In 2016, he moved to left guard after Jacksonville added free agent Kelvin Beechum during the offseason. Injuries have been a problem for Joeckel . Joeckel was drafted by the Jaguars with the second overall pick in the 2013 draft. That's a significant amount of money for a team that fielded the least expensive offensive line in the National Football League last season.
The US secretary of state has stepped away from dealing with issues related to the controversial Keystone pipeline, because he used to run an oil company. TransCanada had tried for more than five years to build the 1,897km pipeline until former President Barack Obama rejected it in November 2015 amid pressure from environmentalists.
Thousands congregate in Williamsport every August to celebrate global youth baseball. As a result of the Pirates losing a home game, the Pirates have been deemed the "home team" for the 2017 MLB Little League Classic . Baseball Commissioner Robert D. Manfred, Jr., said, "The MLB Little League Classic exemplifies our entire sport's commitment to building a stronger connection between young people and the National Pastime".
On Wednesday, the Washingtonian reports, Cork owners Khalid Pitts and Diane Ross filed an unfair-competition lawsuit against Trump and the Trump International Hotel. Justice Department and served as an administrator for procurement law and legislation at the Office of Management and Budget's office of Federal Procurement Policy, according to the school's website .
Senate Bill 6 would require people in Texas to use the bathroom that matches the gender on their birth certificate in public schools, government buildings and public universities. "We have this bill to chill and handcuff protests made by racial minorities", Thomas said, suggesting the measure represents legislative pushback against the Black Lives Matter movement.
At least 11 Jewish community centers and institutions across North America and four Anti-Defamation League offices have received threats of lethal attack, the sixth such wave since the beginning of the year. In a note to Tucson News Now Tuesday evening, Arizona Senator John McCain stated, "I was deeply disturbed by the threat made against our friends and neighbors at the Tuscon Jewish Community Center".
Last week, the New York Police Department said that anti-Semitic incidents were up 94 percent in New York City over this time a year ago. The text of the message, sent by cell phone notification, claimed that three pipe bombs were "scattered throughout the museum" and set to detonate "via a cell phone" at a "busy hour of the day".
Farruggia and Frennette were both arrested this week and charged with reckless conduct. Concord police arrested the expectant mom earlier this week, six months after her son was born. Frenette told the police that, upon entering the bathroom, she felt like she has stepped into a nightmare. It was explained to her that she could have just called 9-1-1, and her attitude was she probably could have, the prosecutor said.
A problem Congressman Cummings said has long crushed American families and seniors. A meeting with top pharma executives in late January appeared to focus more on bringing manufacturing and jobs back to the USA, and lowering regulations than it did direct price negotiation - although Trump did say drug prices have been " astronomical ".


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|Varnish Fine Art at 16 Jessie Street downtown SF
It's nearly ten years since September 11, 2001, and I've been thinking about it all day. Each one of us was changed forever in some way by the tragic losses and the life-altering path of such a time in our lives. We've seen the ability of people to bravely continue after a tragedy and to try living better lives. Bold steps taken in the aftermath of the events of 9/11 account for the lot in life of a lot of folks, including me. We are lucky if we can say that we've tried to bring something positive into the world out of so much suffering, because we at least have had that chance.
So many of us were reminded to live the lives we hoped for right now as a way to respect the value of life and to honor those who lost their lives. The tragedy ten years ago sparked people to come together all over the country---even in New York---for a while at least.
It was soon after 9/11 that Kerri and I decided that we'd live our dream, and after a lot planning and building we first opened Varnish Fine Art in 2003. Today is our first day open at our new space at 16 Jessie Street, and we're very grateful to be here. We're also very grateful for you. Take care everybody!


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We have strong partnerships with industry and, in particular, with leading companies in the information technology and energy sectors. Alongside other collaboration agreements, these partnerships have resulted in the creation of joint research centres with companies like IBM, Intel, Microsoft, Nvidia, and Repsol, with which BSC maintains a stable collaboration and which are another major source of income for our centre.
Deep Learning Center, a BSC and IBM initiative
Joint research since 2005 following on from previous collaboration within the framework of UPC. Research is focussed on: algorithms to improve and expand the cognitive capabilities of deep learning systems; data centric systems including architectures, runtime systems and programming environments; and Deep Learning applications.
Intel-BSC Exascale Lab
Joint research since 2011. The joint research being conducted is orientated to overcome the challenges of Exascale systems: Software tools to analyse and predict performance, Programming models and Performance and reliability of asynchronous algorithms.
BSC-Microsoft Research Centre
The centre targets Big Data topics, aiming to automate the characterization of cost-effectiveness on Big Data deployments. The platform initially focused on on-premise Hadoop deployments, but currently covers a wide range of Iaas, PaaS and SaaS Cloud Services.
BSC/UPC NVIDIA GPU Center of Excellence
BSC's work to improve the technology in NVIDIA GPU accelerators and CUDA architecture culminated in 2011 with it being made a CUDA Centre of Excellence. Research focuses on: GMAC, OmpSs runtime environment and programming model and Automatic vectorisation techniques.
Repsol-BSC Research Center
Joint centre since 2011. Joint research began in 2007. It is a continuation of the Kaleidoscope project to advance seismic imaging technology.The centre specializes in: Full wave-form inversion, Seismic imaging using elastic waves and "reverse time migration" and Controlled source electromagnetic methods.


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Blamé is not a store. It's a testament to the cruelty of victim blaming.
When a woman is raped it can weigh on her for the rest of her life. Telling her that she deserved it because her hemline was too short, or her lipstick was too sexy, is cruel and ignorant. Browse our collection. Ask yourself if any of what you see is an invitation to rape.
YWCA Canada is the country's oldest and largest women's multi-service organization. With 32 Member Associations in more than 400 communities, YWCA Canada is the nation's single largest provider of shelter to women and children fleeing domestic and sexual violence. For more information, visit www.ywcacanada.ca


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My Cousin Vinny Trailer (1992)
"Truth, Justice and the Gambini Way" 13 March 1992 Drama, Comedy 120 mins
Two carefree pals traveling through Alabama are mistakenly arrested, and charged with murder. Fortunately, one of them has a cousin who's a lawyer - Vincent Gambini, a former auto mechanic from Brooklyn who just passed his bar exam after his sixth try. When he arrives with his leather-clad girlfriend , to try his first case, it's a real shock - for him and the Deep South!
Watch the official My Cousin Vinny 1992 trailer in HD below or find more My Cousin Vinny videos on Vidimovie.


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The biggest and possibly only knock on receiver Cordarrelle Patterson coming out of Tennessee was he might be a little too raw and may lack the mature learning capacity to grasp an NFL offense immediately after only one season of major-college football.
Obviously, Patterson, disagrees.
The Vikings hope he's right because they shipped four draft picks to New England to move back into the first round and take Patterson 29th overall.
It's still very early in the process, but the Vikings were impressed by how seriously Patterson took this past week's rookie minicamp from a classroom standpoint. He spent about two hours studying his playbook on Thursday night, the eve of the three-day camp. Then he woke up early Friday and brushed up some more on his job as the 'X' receiver in about 20 pass plays that would be run that day.
"They're just seeing how much we can learn by throwing it at us this quick," Patterson said. "But it's not what I expected. I'm getting it faster than I thought I would."
That, of course, could change as more is thrown at him.
Even Patterson admitted as much. But he doesn't buy the notion that he'll fall behind the normal learning curve for an NFL receiver. Not with all the special attention that he was seen receiving from Vikings receivers coach George Stewart.
"I really don't think it's going to take that long," Patterson said. "Coach Stewart has already said he and I are going to have a lot of sessions. So he'll make sure I know everything. We're going to spend extra time. I know everything is going to be good."


text: I have been having the same issues as many people have been having with there phones from not being able to make calls to apps and internet foreclosing to not being able to unlock my phone. I called verizon to complain about my phone and I was informed that they will be releasing new software to fix the issues that everyone has been having. The software can come out any where from July 16th and on it will take time for the update to be on the notification bar. so be looking for the update I was told it should work but there are no guarantee i was told. fingers crossed it will work.


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We're Hiring News and Tech Writers
under construction.
Quickfever is looking for contributors and authors. You'll need experience, a nose for tech, and above all, love for Quickfever and helping people at their very best lives. Quickfever is a tech content media website where we help people understanding and use technology in a better way.
A Bit of us.
- 1,00,000+ Page Views / month
- Work remotely, get paid Internationally
What exactly we're looking for
We're looking for writers to cover how-to guides, general tech articles, and someone who can write explainer across a myriad of topics.
To be particular we do need.
Tech writer: Familiar with Windows, security, troubleshooting, and related topics.
General tech writer: you believe you're the jack of all tech trades, this job is for you.
A Windows writer: Windows knowledge is your plus point, you love spending hours finding new things can be done on Windows operating system.
Currently, we have only part-time positions available, so you can write daily or weekly or even monthly.
All of our writers should have these qualities.
- You must be able to write general tech articles, how-to guides, explainers, Tips and suggestions.
- You should have a personal computer and should be at least 16 years old.
Here are some of the previous articles, take them as examples to figure out what exactly we're looking for.
List article: 15 Alternative Operating Systems For Your Computer
How to: How to Delete Temporary Files in Windows 10
Troubleshoot: Windows 10 Store App Stuck and Not Working? How to Fix
Explainer: What Operating System does I have? Here is how to Find out
How to apply
Send an email to email@example.com with the subject "Quickfever Writer" and include the following in your email.
- Your name and location.
- Any previous experience you have with writing and/or blogging.
- A brief overview of the topics you are familiar with, and what operating systems and devices you use.
- Expected Rate per Article
- Self-written article.
- Updated resume or a portfolio link.
Ensure that your post does not violate any copyright laws and we will only publish unique content (articles that haven't been published before).
Apply on: email@example.com or Ping our Facebook page.


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GENEVA, Jan 3 (Reuters) - The managing director of oil trader Vitol could move its headquarters from Geneva if Switzerland hiked taxes on big commodity traders, and others would do the same, Vitol's managing director said in comments published on Friday.
"We could - and we wouldn't be the only ones - move the domicile of our assets elsewhere," David Fransen told Swiss weekly magazine L'Hebdo in an interview.
Switzerland has come under pressure from the European Union to end so-called "fiscal holidays", including those which the canton of Geneva offers to major trading firms such as Vitol, Mercuria and Gunvor.
Geneva has proposed a flat 13 percent corporate tax rate for trading houses, signifying a rise from the 11.6 percent paid by the big firms but a cut for companies that do not qualify for special tax breaks, who currently pay 24.2 percent.
Since the reform would leave a 460 million franc ($511 million) hole in the canton's budget, Geneva has said it cannot guarantee the reform will get through.
Fransen said Vitol could live with a 13 percent tax rate but Switzerland would suffer greatly if it doubled the tax rate on big Geneva-based trading firms such as Vitol.
Vitol is privately held and does not publish detailed financial accounts. But Fransen said its gross margin on sales of $303 billion was "much less" than 1 percent.
Geneva is the hub for a third of the world's physical oil traded volumes, according to the Geneva Trading and Shipping Association. For Switzerland as a whole, the commodity sector accounts for around 3.5 percent of gross domestic product and employs around 10,000 people.
In April the co-owner of Gunvor, Gennady Timchenko, said the trading house could move to Singapore, a rival trading hub, if Switzerland became less attractive. However, Timchenko said he was confident a solution would be found and added the company was not looking to move.
Most global commodity firms already have branches in Singapore, which can offer tax rates as low as 5 to 10 percent through its Global Trader Programme.
Vitol has been happily based in Geneva for 47 years but Switzerland was gradually accumulating disadvantages, such as the cost of living, while Dubai, Singapore and even the United Kingdom offered competitive tax regimes, Fransen said.
The slow pace of Swiss reforms, with a new tax regime expected only in 2018 or 2020, ensures that companies have the stability and long-term visibility that they need.
"But be careful not to take too long: some countries, like Singapore, are making great efforts to attract new companies and exploit the uncertain times that come with reforms." ($1 = 0.9008 Swiss francs) (Reporting by Tom Miles, editing by William Hardy)


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Not only is Miami magnetic to people who want to call the U.S. home, but it is has also become irresistible to entrepreneurs. According to the Ewing Marion Kaufmann Foundation, which studies and supports the startup community, Miami is now the second most entrepreneurial city in the US, and can boast the nation's highest startup density. Last year's Kaufmann Index found that Miami led the country with 247.6 startups per 100,000 people. Miami is borrowing from other cities - such as Austin and Boulder - which don't seek to become a carbon copy of Silicon Valley. Instead, Miami chooses to play on its many strengths. According to published reports, Miami has attracted the attention of entrepreneurs from around the world for better than two decades. More recently, new clusters of energetic visionaries have come together to groom a new playing field. This includes neighboring universities, where many startup cultures find like-minded individuals, and cred from the loc...
- According to the Ewing Marion Kaufmann Foundation, Miami is now the second most entrepreneurial city in the US.
- Miami also has the nation's highest startup density per capita.
- Miami is now home to 139 startups and companies on the Inc. 5000 list.
Future-Proof: Navigate Threats, Seize Opportunities at ICNY 2018 | Jan 22-26 at the Marriott Marquis, Times Square, New York


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People in the streets of Istanbul in one of the central regions of city named Kadikoy district. Historically known as Constantinople and Byzantium, Istanbul is the most populous city of the country Turkey and the country's economic, cultural, and historic center.
Kerem Gogus
Yalova, TR
Interact, make friends, share tips and techniques, have fun. Dreamstime wants your ideas and thoughts whether you are a photographer, designer or regular user. Create a blog to tell your story, promote favorite images and photographers, post tutorials or simply exchange opinions with your with fellow dreamstimers.
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The object of this game is to swim underwater and use your suction cups to kill the creatures. You get 10 points for each one you kill and 100 bonus and next round for all four. Free man every round after five.
Freeware - Download PocketPC SquidCreatures© Now!
To run these Pocket Visual Basic programs you need the free Microsoft Distribution Source Files located at http://www.CeBeans.com/runtime/runtime.htm
Click here to go to the Free Windows CE Software Website
(c)1998-2007 Vincent Collura ( Inventor / Engineer )


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View in a larger map
→ Comstock expands homebuilding into active adult market
→ Comsstock announces new Senior VP for Land Acquistion and Development
→ Comstock Garners 2 GALA Awards!
→ Comstock Garners 4 GALA Awards!
→ Comstock to Build Maxwell Square
→ Comstock Opens Falls Grove Sales Center
→ Comstock Opens Townes At The Hampshires
→ Comstock Opens Townes at Maxwell Square
→ New townhomes coming to historic downtown Frederick
→ Home prices still surging ... for now
→ Forbes: Loudoun is America's Richest County
→ "We're in Nirvana for Housing": Zelman
Comstock Real Estate Services, LC (CRES) is uniquely positioned to serve the diverse real estate related needs of property owners, financial institutions, and real estate investors. With a service delivery platform that is able to draw on resources of the entire Comstock organization, CRES is able to quickly assess assignments, develop strategy, and execute a plan that meets the individual needs of each client.
Among the services offered by CRES are:
- Value protection and enhancement
- Strategic planning for asset recovery or liquidation
- Project entitlement management and/or use modification
- Master planning and project rezoning management
- Adaptive re-use of existing structures
- Environmental issue resolution strategies and management
- Project management, including land development and construction
- Management of public-private partnerships
By efficiently developing solutions designed to create long-term value for all stakeholders, the Comstock organization has earned a reputation for producing results that are Worthy of the Investment.
To contact a CRES representative, click here.


text: Does anyone out there have a save file somewhere close the 'Stardust Hunter' achievement. I have been grinding this out for quite a while but have lost all interest, my chars are well over lvl200 and the fights are easy but there are just far too many left to do! Any help woud be greatly appreciated!


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Junior Blazer Camps – Girls age 5-10, Time 8:30AM-12:00PM, Cost $215 per week.
The Junior Blazer three-week summer experience will allow girls between the ages of five and ten to interact, socialize and have fun while being welcomed into and exposed to the Trinity community. The camp will be supervised by Trinity faculty and members of our current student body.
The camp will run for twelve days and campers will enjoy a variety of themed activities.
Junior Blazer (girls age 5-10)
Week 1: June 12 – 15
eek 2: June 19 – 22All weeks of Junior Blazers are now full. Please email Ms Bedell at firstname.lastname@example.com to be put on a waiting list
Week 3: June 26 – 29


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2014.03.20 Thursday
Things Gathered from Nature
We are delighted to celebrate the third anniversary of Matsuya Ginza Babaghuri with a small exhibition of pieces made of stone, coral and shell.
Designer Jurgen Lehl has specially selected the materials from those he found on seashores and river banks. The stones, fragments of coral and shells have been washed by the sand and waves, creating beautiful natural contours which have been formed into a range of jewellery, ornaments, chopstick rests and soap dishes.
And we have the special blog for this exhibition.
Please come and see our new site.
Jurgen Lehl for Babaghuri
We look forward to seeing you at Matsuya Ginza Babaghuri.
Matsuya Ginza Babaghuri
2014.3.19 - 31
tel: 03-5524-2530
address: 7F 3-6-1, Ginza, Chuo-ku, Tokyo


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If you want to have a memorable dinner with delicious meal and great views, maybe Juvia Penthouse Restaurant is good for you. It's located on Miami, exactly on top of one of famous landmarks on Miami, 1111 Lincoln Road Parking Garage, designed and conceptualized by Herzog & de Meuron. This peculiar restaurant offers you a luxurious interior in open space concept, with great charming views of Miami especially nighttime. Your dinner is more than a meal of course.
The focal view orientations are Venetian Causeway and South Beach, not to mention Miami town itself. While the restaurant itself is combined as part of 1111 Lincoln Road parking building, the function carried by this restaurant is clearly different, thus the restaurant and the building itself are designed in unity of exterior performance. To allow the visitors accessing the views, all of surrounding opening is filled with glass windows; create transparent performance, exposing the view to interiors. There are two separates room, indoor restaurant and outdoor restaurant. Both use same material tile, wood, indoor restaurant is designed with pale wood ceilings, modern table and seating with purple accent, with dark brown wood as the floor. The spotlights are installed on wood ceiling. Outdoor restaurant is created with same concept of wood and combination of purple and metal material. Vertical garden with various plants, add the atmosphere of natural touch. Elegant and classy, luxurious and deluxe dinner experience with great views of Miami and delicious Juvia penthouse restaurant menu, can you resist this glamour dinner?
Penthouse restaurant tavern is located on indoor restaurant. Indoor restaurant is designed to be glamour and rich with textures, thus, artificial lighting is placed to illuminate the table in vivid, yet subtle light is spread and accentuate wood texture of all interior elements. That's grand and luxurious atmosphere indeed.
If you're person looking for a place with luxurious and glamorous atmosphere with great views, with large fortune in your hand, this penthouse restaurant worth to try.


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They have come from Covent Garden, walking along Henrietta Street and turning into Gin Lane, making for The Strand. Gin Lane is filthy, dirty gutters, wretched houses with broken windows, ("Beware the slops, Master," says Forlan), windows patched with rags and paper and, out behind, hideous stinking drains and latrines and, behind them, the dark hulk of Newgate Prison. The only building in good repair is the pawnbroker's shop, its windows heavily barred.
A drunken woman sprawls on the pavement while her child picks about in the gutter. A man fights with a dog for a bone. Old men, drunken, besotted, stagger by. Wretched, broken-down, miserable women shuffle along. A group of young men standing on a corner look at Grotius and Forlan, with feral eyes, move forward, but then hesitate. Grotius and Forlan step round a drunken fight between labourers in the gutter. A man dressed like a parson stands in the middle of an ill-coloured puddle reading loudly from a tattered bible.In a doorway is a group of young women.
(Extracted from 'the Search for Gabriella.')


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Print many sites.
Thank you for downloading Print Multiple Web Sites Software from our download portal.
Current files are located on the following IPs: 220.127.116.11
Outer mirror site one (www.sobolsoft.com)
Note: We prefer to use WinZip, WinRar, WinAce, 7zip to extract zip, rar, 7z, ace files. For data iso files we recommend you use freeware Daemon Toos lite.
Note: All files listed on this site are tested by the ESET Smart Security. If you like to test this file by another security software we recommend you select some in our antivirus section.
printing, websites, pages, printer, sending, webpages, internet explorer, multiple, several, world wide web, in a row, one after another, all at once, content, css, php, design, server


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Happy Fathers Day Images 2017 Father's Day HD Wallpapers Pictures Pics Cards Quotes: This year, Father's Day is going to be celebrated on June 18, 2017. It is around the corner. Usually celebrated on every third Sunday of June. You might probably have bought some gifts or stuff for your dad, but it is incomplete without a special mention or greeting, which is exactly what you will find in this article. (share: fathers day quotes.)
There is no bond like a child shares with his father. You feel secure around your father; he protects from any harm getting caused to you. To see you happy, he could do anything; from buying you the desired stuff to let you ride piggyback. Feel proud to have a father, very lucky people have this chance.
Happy Fathers Day Images 2017
This June 18, it is the perfect time for you to thank your father for everything he did to make you smile and holding your hands in tough times. Make him feel special and tell him how much he means to you. In the last, that guy is going to stand strong between you and bad situations you would counter even in future.
We have prepared a diverse collection of Father Day Messages 2017 Wishes & Greetings to let you choose the best lines which suit your dad. (check: When Is Father's Day 2017?.)
A father has sacrificed his being and dedicated all his will to keep you happy. He has seen you grow from childhood to adulthood; he made you a human being.
Cheers to that person called Dad. Go ahead and greet him.
Stay tuned to TheReporterTimes for more news and updates.
Don't forget to share your views and thoughts on the occasion with us via commenting below. Feel free.


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Bill Gates startup life path visualized in an infographic. You will see how he learned to create and think like a genius.
Bill Gates, Entrepreneur and Philanthropist
The 50 Philanthropists Who Have Given Away The Most Money Bill Gates
Billionaire Bill Gates has said he reads about a book a week. We sifted through years of his book recommendations to find 12 that made especially strong impressions
Bill Gates vs Steve Jobs in a glimpse


text: ARE YOU WORTH YOUR WAGE? We are looking for talented professionals who are absolutely worth their wage to appear in a new series for Channel 4 about working life and pay in Britain. The purpose of the series is simple. We will follow a small group of talented individuals with contrasting jobs and salaries as they spend time experiencing and comparing each other's working lives. We are particularly keen to find successful individuals willing to demonstrate the hard work, responsibility, working hours and pressure that comes with being a high-earner. This series goes beyond tabloid stereotypes and instead of criticising high earners - instead looks at why different jobs are worth their wage. We want to challenge preconceptions about certain professions and break the taboo about revealing how much we earn. Are you stereotyped based on your job? Would you like the chance to set the record straight about your profession and show how you are worth every penny? To register your interest or for more information email firstname.lastname@example.com or call Sarah on 0207 241 9300.


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Bernat Blanket and Blanket Brights Yarn 300g
This is my Ballerina Wide Easy Lace Headband and Bun Cover knitting pattern. This is a fantastic matching set for any budding ballerina. This set uses only uses one 50 g ball of yarn so is a great way to knit a luxurious item without breaking the bank. Both items are really quick and easy to make yet the results are truly stunning. They are worked flat on 3.25 mm needles and can be made in any dk (8ply) yarn of your choice. This knitting pattern provides full instructions for 3 sizes: S (child), M (teen/small woman) and L (woman/man). This knitting pattern is available to buy here as a pdf download.


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RIYADH, Saudi Arabia — Defense Secretary Robert M. Gates met with King Abdullah bin Abdul Aziz and other top Saudi officials Wednesday, at the start of his third trip to the tumultuous region in the past month.
"We had a very good meeting," Gates told reporters traveling with him, after speaking with the king for 90 minutes. "It was an extremely cordial, warm meeting. I think the relationship is in a good place."
In addition to Abdullah, Gates met with Prince Khalid bin Sultan, one of the Saudi government's top defense officials.
Late Wednesday, he traveled to Baghdad for what is widely expected to be his final trip to Iraq as defense secretary. During his three-day trip, he is to meet with Prime Minister Nouri al-Maliki and U.S. troops and visit northern Iraq.
On the agenda for Gates's meetings in Baghdad is the question of what role the U.S. military will play after the end of the year, when the planned troop withdrawal is scheduled to be completed. A senior defense official traveling with Gates said that if Iraq wants some small U.S. force to remain, the request should come soon.
"The ball is in the Iraqis' court," the official said, speaking on the condition of anonymity. Gates "has made it pretty clear that these things don't happen overnight."
U.S. relations with the Saudis have been strained in recent months amid spreading unrest across the Arab world. Saudi officials have voiced unhappiness that the Obama administration urged the departure of Egyptian President Hosni Mubarak, a longtime ally, following a popular uprising.
And in March, the Saudis sent troops and tanks into neighboring Bahrain to help quell demonstrations at a time when U.S. officials were advocating an approach based on negotiations. Bahrain is home to the U.S. Navy's 5th Fleet and is regarded as a strategically important bulwark against Iranian power in the region.
During Wednesday's visit, however, U.S. defense officials minimized reports of tensions with the Saudis. Gates said he did not raise any concerns with Abdullah about the Saudi troops in Bahrain.
Gates had also planned to report to Abdullah on the progress of a $60 billion arms deal with the Saudis and to discuss plans for upgrading the nation's missile defense system, U.S. officials said. Saudi Arabia is the largest buyer of U.S. arms. Iran, which officials say is seeking to exploit the political upheaval in the Arab world, was on the agenda for discussions, as well.
At a time when U.S. officials have sharply criticized other Arab nations for their handling of pro-democracy unrest in the region, Gates planned to urge "evolutionary" reform and respect for human rights in Saudi Arabia. There have been only small protests here so far.
The senior defense official said the United States needed to take a "pragmatic approach" in dealing with such a close ally.
"They're going to have to find their own path," the official said.
Gates made two visits to the region last month, stopping in Egypt, Israel, Jordan and Bahrain. He left Bahrain expressing optimism that the government there would take a cautious approach to pro-democracy demonstrations, but the Saudi troops entered the country days later, and the violent crackdown followed soon afterward.
Gates was also supposed to visit Saudi Arabia last month, but that visit was canceled because of Abdullah's ill health, U.S. officials said. The king's condition has since improved, the officials said.


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In the situation when you don't know your database username and password.You can follow this guide to retrieve your username and password for your database using directadmin panel 1) Login to the directadmin panel
Search our database
Change Directadmin password
You can change your default ftp account password, main database password and your directadmin password from the directadmin control page. Simply follow this steps: 1) login to your Directadmin page 2) Click "Change Password"
How to change MySQL database user privileges (DirectAdmin)
Login to DirectAdmin and go to "MySQL Management" Select the database which the database user is assigned to Click "Modify Privileges" Set the required privileges for the user, then click "Save"
How to retrieve lost MySQL's username and password for Direct Admin
Lost your MySQL's username and password? Here's the way to retrieve it. 1. SSH into your server, command as below ssh "IP" -l "username" -p "port" 2. Type in the below command: cat /usr/local/directadmin/conf/mysql.conf 3. The password and username will show as below as it was saved in this location.
How to optimize MySQL database
In the situation where you encountered slow loading webpage, you can try to optimize the your database to improve the webpage loading speed. Below are the few steps to perform database optimization 1. Login to Directadmin.
How to backup SQL database in Direct admin?
In order to backup database, follow the few steps as listed below 1. Login to Direct admin. 2. Click "MySQL Management"
How to start phpMyAdmin on Plesk control panel?
1. Login to Plesk with your control panel username & password. 2. Click "Databases".
How to start phpMyAdmin on DirectAdmin control panel?
1. Login to DirectAdmin with your control panel username & password. Your database must already be created in order to use phpMyAdmin. 2. Go to "MySQL Management"
How to run MySQL query in phpmyadmin
1. Login to your phpmyadmin.
How to disable plugin without going into WordPress admin
1. Login to phpMyAdmin with your wordpress database username & password. 2. Select your database name from the pull down menu on the top left of the screen. (if you have more than one database associated with database username)


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Every industry and business relies on a number of different professionals to dispense advice and provide expert services. However, it's no longer unusual for headlines to spotlight professionals who stand accused of malfeasance or corruption for work they've performed for both public and private entities.
The downturn in the economy ushered in a rise in professional liability lawsuits as dissatisfied clients looked for people to blame for financial losses and complex business deals gone awry. Other factors contributing to the increase in professional liability claims are legislative changes, such as RICO and Sarbanes-Oxley, and the "deep pockets" doctrine of many plaintiffs and plaintiffs' attorneys. The HITECH Act of 2009 increased the civil penalties and created criminal penalties for HIPAA violations. While these cases most often affect the medical and legal professions, accountants, architects, engineers, design professionals, financial advisors, real estate brokers, insurance agents, therapists, dentists, corporate officers and directors, and even clergy members face legal exposure.
Christian & Small defends a variety of professional malpractice claims in all state and federal courts in Alabama. We also represent professionals in disciplinary and licensing proceedings before administrative agencies and licensing boards. Whether your goal is to seek a favorable outcome at trial or negotiate a settlement without going to court, our professional liability team will work to understand the details of your case and work with you to chart a strategy for the best possible resolution. Our attorneys have the legal skills, industry-specific knowledge and ethical grounding to make it happen.
Medical Malpractice
Medical liability claims were rare until the 1970s in the United States. Since then, the number of medical malpractice lawsuits has reached epidemic proportions. The average cost of a malpractice claim has risen to the hundreds of thousands, and beyond the financial toll of each claim, comes the rising cost of med mal insurance and professional liability premiums, stress, damage to professional reputation and distraction from what most doctors want to do most – practice good medicine.
Christian & Small's medical malpractice attorneys are highly respected for their vigorous defense of health care providers and practitioners against the complicated and often emotion-filled claims of malpractice. Our attorneys are counsel to several large hospitals and professional liability insurers and have successfully defended numerous cases involving a multitude of claims. Over 50 years of expertise affords our medical malpractice defense group access to a substantial network of resources and comprehensive knowledge of the standard of care, medical procedures and techniques, and the special concerns of expert witnesses.
Our aggressive approach to defending medical malpractice claims includes analyzing each case to see if the plaintiff has met the burden of proving negligence, medical mistakes or errors in treatment, unreasonable care and injury. Alabama, like many states, has ruled that capping damage award limits is unconstitutional, so the stakes are always high in terms of future and past medical expenses and non-economic damages.
In addition to our experience in civil courtrooms, Christian & Small attorneys have represented doctors and health care providers in administrative actions brought by federal government agencies, such as Medicare and Medicaid, medical licensing board and professional review hearings. We realize that each medical malpractice claim presents a personal and professional burden to health care businesses and the individual physicians. Our goal in each case is to alleviate some of that burden.
Representative Matters
- Secured defense verdict for general surgeon accused of medical negligence in a wrongful death case.
- Secured summary judgement for a radiologist group concerning its disputed use of a contract medium.
- Secured summary judgement for hospital in eye injury, medical malpractice case.
- Secured summary judgement for physician accused of misdiagnosis and over treatment of cancer.
- Successfully defended general surgeon. The Plaintiff claimed in excess of $400,000 in past medical expenses and $350,000 in lost wages due to permanent disability. Her husband also made a claim for loss of consortium. Jury returned a unanimous verdict in favor of the surgeon.
- Secured motion to dismiss for physician in wrongful death case.


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Supervision and Testing Center Food Quality
Supervision and Testing Center Food Quality
Sun F.,Xinjiang Academy of Agriculture and Reclamation Science |
Sun F.,Supervision and Testing Center Food Quality |
Luo X.,Xinjiang Academy of Agriculture and Reclamation Science |
Luo X.,Supervision and Testing Center Food Quality |
And 5 more authors.
Polymer Chemistry | Year: 2015
Hyperbranched polymers (HBPs) have attracted increasing attention of scientists due to their unique physical and chemical properties, as well as their potential applications in different fields. Many methods for the preparation of HBPs have hitherto been reported. This review focuses primarily on several novel synthesis methods for various HBPs. We present and discuss the advantages and disadvantages as well as recent advances relating to such synthesis methods, namely the slow monomer addition method, click chemistry, and the enzyme-catalyzed polymerization method. Besides, the applications of HBPs in analytical chemistry fields such as sample pretreatment and immunosensors have also been briefly summarized. This journal is © The Royal Society of Chemistry.
Lu C.,Xinjiang Academy of Agriculture and Reclamation Science |
Lu C.,Supervision and Testing Center Food Quality |
Luo X.,Xinjiang Academy of Agriculture and Reclamation Science |
Luo X.,Supervision and Testing Center Food Quality |
And 8 more authors.
Journal of Separation Science | Year: 2013
In recent years, ionic liquids have become increasingly attractive as 'green solvents' used in the extraction of bioactive compounds from natural plant. However, the separation of ionic liquid from the target compounds was difficult, due to their low vapour pressure and high stabilities. In our study, ionic liquid-based ultrasonic and microwave-assisted extraction was used to obtain the crude tannins, then the macroporous resin adsorption technology was further employed to purify the tannins and remove the ionic liquid from crude extract. The results showed that XDA-6 had higher separation efficiency than other tested resins, and the equilibrium experimental data were well fitted to Langmuir isotherms. Dynamic adsorption and desorption were performed on XDA-6 packed in glass columns to optimise the separation process. The optimum conditions as follows: the ratio of column height to diameter bed was 1:8, flow rate 1 BV/h (bed volume per hour), 85% ethanol was used as eluant while the elution volume was 2 BV. Under the optimised conditions, the adsorption and desoption rate of tannins in XDA-6 were 94.81 and 91.63%, respectively. The content of tannins was increased from 70.24% in Galla chinensis extract to 85.12% with a recovery of 99.06%. The result of ultra-performance liquid chromatography (UPLC)-MS/MS analysis showed that [bmim]Br could be removed from extract. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


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The Team
They're a committed team of creators consisting of an arts educator, a Web developer, a producer, a graphic designer, a copy editor and a videographer. All are working professionals in their own right. But by combining forces, they have turned ambitious ideas like this one into reality. (From left to right: Rusdon, Caitlin, Andy, Sam, Bjorn, Nate.)
+ Andy McInnis
- Andy jumps into things with both feet before realizing what the hell he's actually doing. A prime example is when he started screen printing out of his apartment back in 2007. If this book had existed then, Andy might have actually made something of himself and you wouldn't be reading his bio right now.
Both Andy's parents are very talented teachers. Although he never intended to take over the family business, teaching is what he was meant to do. Art and education are two of this young man's deepest passions. Commitment is an issue for Andy, but the SPOTC team keeps him in check.
Technically homeless with a laughable credit score, Andy sacrifices things most wouldn't in order to find true love. From time to time he grows the hair out on his upper lip.
Andy's current relationship status is: SPOTC.
+ Bjorn Hagstrom
- The most efficient decision maker that side of the river. When in doubt, ask Bjorn. Fuzzy about what's on your plate? Ask Bjorn and he'll show you what's right in front of your face. He simplifies the complexity.
In addition to his high-end Web development work throughout the Net, Bjorn's background in the screen printing community is extensive. Having produced graphic artwork for several years, and being a screen printer himself, the knowledge he brings to the table is invaluable.
The bottom line: Bjorn figures out how to make things work when no one else can. Coolest, most handsome Web nerd you'll ever meet.
Bjorn brings SPOTC into the twenty-first century and beyond.
+ Caitlin Hargarten
- The most organized artist in Minneapolis. With her, we find our balls tucked neatly into a nice wicker basket. Caitlin's ever-positive energy keeps projects like this going through thick and thin. Outside SPOTC, she can be seen organizing art events, creating animations and screen printing out of her garage.
Caitlin's recognition starts at a grassroots level. She's managed projects such as the Red Hot Art Festivals and Art Shanty Projects, and she runs a video production company, Squawk Productions, with her husband, Sam.
Caitlin holds SPOTC accountable.
+ Nate Johannes
- Nate's attention to detail is ridiculous. He is a game changer. Idea generator extraordinaire. Idea executor till four in the morning. How does Nate have the ability to generate and execute ridiculously ambitious ideas all at once, you ask? We may never know the answer … dude is a total freak.
Nate follows through on every project he agrees to. And he agrees to a lot. His timeless design skills win awards as he continues to feverishly work for the underdog. He's got a humble heart a gold.
Mr. Screen Printing on the Cheap. He loses small objects in his facial hair.
Nate gives SPOTC its sexy.
+ Rusdon Torbenson
- Consistency is key. When it comes to the English language, Rusdon knows it like the back of his hand. Sometimes, he'll even use the back of that hand to enforce the rules.
But, rules are meant to be broken. Anyone can write; few can edit. This gentleman knows the art of cutting through the crap and clarifying the cloudy. He'll reteach you things you should have remembered from grade school.
Rusdon's professional accomplishments include
1. having a lot of fun proofeading for Aveda and Fallon (sic, sic fun);
2. editing copy for Minneapolis's dandy and dead Art Review and Preview; and
3. getting 19/20 on his eighth grade spelling test (choked on "larynx").
Rocking Chuck Taylors and junior miss jeans twenty-four/seven, three-sixty-five.
Rusdon keeps SPOTC clean, concise and consistent.
+ Sam Thompson
- This dude is a natural-born promoter who can be found slanging homemade horror films in his sleep. Sam's professional work outside SPOTC can be seen in the form of feature-length and short films, music videos, motion graphics … the list goes on.
To this project Sam contributes mad skills with a video camera, his photographic lens, promotions, marketing and humor. He has directed the feature film "Living Arrangements" and the award-winning short film "Urine Trouble." He runs Squawk Productions with his wife, Caitlin.
Sam's zombie blood positively pumps through SPOTC.


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Don't miss this chance to learn more about oil& gas development in your community—and who to call if you have concerns!
When: Wednesday, September 30th. The English presentation will be from 6pm—7:30pm, followed by a Spanish presentation.
Where: La Salle County Emergency Operations Center, 247 Mars St., Cotulla, TX 78014
Cost: Free, and open to the public!
I'll be there!
Dear EDF,
Thank you,[Your Name] [Your Address] [City, State ZIP]
257 Park Avenue South, New York, NY 10010Donations/General Information (800) 684-3322 or email us
Media contacts | Other contacts | About this site | Privacy policy
Copyright © 2017 Environmental Defense Fund. All Rights Reserved.


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Nigeria guys will add you up on Facebook and they'll be like
boy- hi
girl- hello
boy- how are you
girl- am fine and you
boy- am OK, are you on WhatsApp?
girl- no am not
boy- can I have your number?
girl- no,
boy- you look pretty on your dp, wow all your pictures are lovely. I like you because I have never seen anyone as pretty as you are
girl- wow thanks
boy- give me your number please am not like other guys. I won't disturb you. I need to keep in touch because am not always on line
if the girl stands her ground and say no the boy will unfriend her
Nigeria guys why do u like to beg for number on Facebook? Mark zuckerberg knew why he designed Facebook and made it optional for one to add his mobile number so stop begging for number on Facebook.
Don't Forget to visit http://www.olamzy.com for more gists...


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How to Get the Starting Speed Boost (Rocket Start)
Like in previous Mario Kart games, you can get a helpful speed boost at the starting line in Mario Kart 8. You'll have to time this one perfectly to get a boost. Watch the numbers closely as they fall into place.
As soon as the number 2 drops to the bottom, hold down the accelerate button -- you will blast forward ahead of everyone else who doesn't know how to boost. Note that if you are a bit early and hit the button while the 2 is still in the air, you will spin out.
Top Wiki Contributors
Need assistance with editing this wiki? Check out these resources:
What Links Here
How to Get the Starting Speed Boost | Mario Kart 8 Launch Guide


text:
Most Canadians who know about the Occupy Wall Street movement view it favourably, a new poll has found, reflecting anxiety over job prospects and savings plans amid Canada's fragile economic recovery.
The Nanos Research poll conducted for The Globe and Mail and La Presse found that 58 per cent of Canadians who are aware of the protests have a favourable or somewhat favourable impression of them.
Many of those who see the Occupy movement in a positive light said it's because they either support the demonstrations or think protesters are expressing valid concerns.
"I think the subtext is Canadians worrying about a possible second recession, regardless of the fact that Canada has fared relatively better compared with other countries," said pollster Nik Nanos. "People are worried about their jobs and they're concerned about their savings."
Occupy activists have pitched tents in at least eight Canadian cities, building on a protest movement that started in New York's financial district nearly two months ago. Participants have no official demands, but are advocating for a variety of social justice and economic issues, including nationalizing Canadian banks, closing tax loopholes for the wealthy and increasing the minimum wage. Most say they are frustrated that a small number of people control most of the world's wealth.
"For many Canadians, they might not necessarily agree with those views, but they think that they are valid. Those are legitimate concerns that are being raised about our democratic and financial system," Mr. Nanos said.
The most significant demographic that views the Occupy movement favourably is people who are between 18 and 29 years of age, the poll found, which may be reflective of a tough job market for new workers. Nearly 73 per cent of people under 30 said they have a favourable or somewhat favourable impression of the protests.
Although respondents in their 40s view the protests less favourably than other demographics, about 50 per cent of them still expressed a favourable or somewhat favourable impression of the protests. People in their 60s had the most polarized reactions to the protests, with 34 per cent saying their impression is favourable and 32 per cent saying it is unfavourable.
"It could very well be that for young people that are going out into the job market when things are very uncertain, the Occupy Wall Street movement could be a bit of a rallying point and symbol," Mr. Nanos said.
The poll also found a regional divide in support for the protests, with people in Quebec and British Columbia expressing the most favourable views of the protests, while those in the Prairies had the least favourable responses.
"If you're in Alberta or Saskatchewan, things look pretty good. The economy is strong, there are lots of jobs, the oil sector is very robust," Mr. Nanos said. "There just isn't as much anxiety about the economy and the future compared to other parts of the country."
Most of those who viewed the Occupy protests unfavourably said it was because they believed it was pointless or lacked leadership.


text:
The tubetwist_gg_mac_100.zip file you have requested: Official Demo / TubeTwist Mac Demo - 16.86mb is not available. Upload any files you want to share. This is the only information we could locate:
You are the assistant to a professor whose experiments have unlocked the secrets of time travel! In an attempt to find the missing professor, you must reconstruct the experiments of Project TubeTwist.
We recommend you return to the download list and browse the links from there. If the problem persists, contact us with the details.


text:
FJH Music Measures of Success for String Orchestra-Cello BK/DVD
Item is available as a recurring order
To automatically re-order this item before you run out, select the recurring order option during checkout.
Measures of Success for String Orchestra. Method book. Published by The FJH Music Company Inc (FJ.SB307VC).
This exciting and powerful new string classroom method combines time-tested pedagogy with outstanding sequencing and repertoire. Video icons throughout the method indicate an instructional video on the included All-in-One DVD. Special emphasis on left-h.


text: I have upgraded my phone from iPhone 3G to HTC Desire and swapped my existing 3G SIM into the Desire. I can't, however get my Desire to say it is on the 3G network, i only get a G or H in the notification bar. I have even had O2 send me and connect a new 3G SIM but still no 3G. I am sure i'm in a 3G area as my old phone rolled with 3G where i am. Have i just not swithed it on?? If so how do i do this? Thanks


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What's your least favorite Pokémon [of Each Type]?
View Single Post
September 8th, 2013 (9:14 AM).
Join Date:
Aug 2013
United States
I tried my best to narrow it down, but it was impossible for some of the types. I apologize in advance if I happen to insult a Pokemon someone likes. Remember that it's just my opinion and that I mean no disrespect towards anyone. >< Spoiler tag 'cause it's long.
Bug: Pinsir, Shelmet
Both are downright ugly and have creepy mouths.
Dark: Drapion, Stunky/Skuntank
Drapion looks like a scorpion that fused with a jack-in-the-box, and it's ugly. Real skunks are adorable, whereas Stunky and Skuntank are hideous.
Dragon: Bagon/Shelgon/Salamence, Druddigon
Bagon reminds me too much of Yoshi. Shelgon is just...I don't know, I just don't like it. Salamence's wings are stupid as h***. Druddigon is just really ugly.
Electric: Stunfisk
I literally said to myself "What the h*** is that?!" when I encountered it for the first time. It's facial animation scares me (as does Palpitoad's).
Fairy: Swirlix
That derpy face, and that tail that looks...disturbing.
Fighting: Combusken, Hitmonlee, Hitmonchan, Throh, Sawk
I would have hated Combusken's design anyway, but ever since I read someone's opinion of what it looks like...cannot unsee. Hitmonchan, Throh, and Sawk look too human-like for my taste, and Throh and Sawk look like they should be part rock type. Hitmonlee's design is just too weird for me.
Fire: Chimchar, Combusken
Chimchar doesn't look right for a Pokemon, it looks more like a Sonic or Samba de Amigo character to me. Maybe it's the eyes. Also,
it looks like it lit a fart on fire
. See Fighting for Combusken.
Flying: Pelipper, Tropius
The shape of Pelipper's body, what is up with that? It looks like a flying axe. Tropius' "wings" are as stupid as Salamence's, not to mention the fact that bananas growing out of its neck just kind of grosses me out.
Ghost: Cohagrigus, Spiritomb
Both just seem like really lazy designs to me. And bad designs, at that.
Grass: Exeggcute/Exeggcutor, Tangela
Don't even get me started on Exeggcute and Exeggcutor. Someone really needs to explain to me how a bunch of rotting eggs turn into coconut heads on a walking palm tree. And even if they were unrelated, their designs are still terrible. Tangela's design is just stupid, especially the shoes. It reminds me of those old McDonald's mascots, the Fry Kids, which makes me hate it more (if you have no idea what I'm talking about, just google image search it). Plus, I've done most of my post-game training in SoulSilver at the base of Mt. Silver, and Tangela are
Ground: Diglett/Dugtrio
Lamest designs after Grimer/Muk. How can NO ONE know what the rest of their bodies look like?! Don't they get released inside buildings, or ever have to get serious medical treatment from injuries? Just stupid.
Ice: Jynx
She and her clothes look way too human-like (and I don't care that she's the "Human Shape" Pokemon).
Normal: Happiny, Lickilicky, Patrat/Watchog, Smeargle
I hate Happiny's design, especially the bumps on her head. Lickilicky is just stupid. I was so disturbed when I saw the artwork for Patrat and Watchog for the first time - their eyes are disturbing, and Watchog just has a plain hideous design. Smeargle just bugs me.
Poison: Drapion, Garbodor, Stunky/Skuntank
See Dark for Drapion, Stunky, and Skuntank. Garbodor is self-explanatory.
Psychic: Exeggcute/Exeggcutor, Jynx, Mr. Mime
See Grass and Ice. (Mr. Mime is in the same boat as Jynx.)
Rock: Nosepass/Probobass
Some of the worst designs for a Pokemon, imo. Don't know what else to say.
Steel: Probopass
See above.
Water: Keldeo, Pelipper
Keldeo looks like an awful My Little Pony fan character. I particularly hate its nose. See Flying for Pelipper.
Woo, so nice to get that off my chest. XP
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A leading Christian community-based institution for holistic health of persons, groups, and integrity of creation.
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Within timeframe of ten (10) years Marina Mission Clinic (MMC), as a Christian community-based health institution, shall have attained a development status and stability manifesting the following features:
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The use of biologics as immune modulators in several autoimmune diseases has provided new tools to the physician's therapeutic armamentiarium and has led to improved patients' outcomes and quality of life. By producing autoantibodies, B cells in SLE are key players in the pathogenesis of the disease and in its clinical manifestations. Therefore, biologics that target B cells in SLE aims at reducing the activity of these cells for the induction of remissions and/or amelioration of disease activity, reduction of organ involvement, and limitation of the complications and side effects caused by immunosuppressive therapies.
This review describes the past and current clinical trials with B cell-targeted biologics in SLE, to provide a historical perspective and the state-of-the-art on the topic.
We will review how the disappointment in the field from promising agents has been instrumental in providing valuable lessons leading to an improved design of new trials that are now giving encouraging results
In systemic lupus erythematosus (SLE), the use of B cell-based biologics in clinical trials has shown both disappointment and promise
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the involvement of multiple organs and by the presence of dysregulated immune responses. These include immune aberrations associated with an impaired immune tolerance (partly related to the availability of self antigens secondary to abnormal apoptosis), abnormal patterns in the expression of pro-inflammatory and anti-inflammatory cytokines, hyperactivity of T helper and B cells, and hyperproduction of autoantibodies. Since autoantibodies can bind self-antigens and form immune complexes that can deposit in tissue (where they can activate complement, promoting local inflammation that can cause tissue damage), one of the therapeutic goals in the treatment of SLE is the blockade and/or the reduction in the levels of autoantibodies in patients. Consequently, one modality of intervention in the disease considers the depletion and/or the blockade of B cells that make antibodies that have a pathogenetic role in the disease manifestations and/or complications.
Clinically, the multi-organ involvement and the broad spectrum of manifestations in SLE patients represent a significant challenge for the physician, both in terms of diagnosis and management of the disease. Although the mortality and morbidity of SLE have significantly improved in the last decades due to the development of better tools for diagnosis, improved therapeutic protocols, and a better knowledge of the disease pathogenesis, fatal complications from the disease do occur. The disease complexity and heterogeneity of clinical manifestations among patients can sometimes result in therapeutic unresponsiveness for certain patients. As a result, disease can progress and lead to the development of organ damage, sometimes with ill-fated consequences. Also, the frequent use of immunosuppressive agents in SLE may often cause undesired side effects, and favor the development of complications such as infection. Thus, the addition of new therapeutic agents is long awaited to possibly improve the management of the disease. In this context, biologics represent promising candidates.
The use of biologics has significantly impacted the therapy of several diseases, including systemic autoimmune conditions such as rheumatoid arthritis (RA). The success of TNF inhibitors in RA has somehow paved the way to the development and use of other biologics in other autoimmune conditions, including SLE.
One biologic therapy in SLE employs the use of monoclonal antibodies that target single specificities (generally present on the surface of selected immune cell subsets) without affecting other molecules. One advantage of this approach is the specificity in selecting only those cells that need to be targeted for depletion or functional blockade. Another practical advantage is represented by the possibility to easily produce large amounts of monoclonal antibodies through hybridoma techniques.
Mechanistically, the therapeutic effect of monoclonal antibodies in vivo can be ascribed to different activities that can be summarized as antibody-dependent cell-mediated cytotoxicity (ADCC) and complement dependent cytotoxicity, or induction of apoptosis.
Four types of monoclonal antibodies have been made available to the clinic: murine antibodies, chimeric (fusion proteins where the receptor that provides specificity is linked to an immunoglobulin) antibodies, humanized antibodies, and fully human antibodies. The two last types of antibodies have obvious reduced antigenicity in humans, possibly exhibit longer half-lives, and may thus carry lesser risk of limited therapeutic efficacy in the recipients.
While acknowledging the variety of the new therapeutic approaches in the treatment of SLE such as the use of biologics that interfere with co-stimulation or that promote immune tolerance, we focus in this review specifically on the biologics that directly target B cells.
The central role of B cells in the pathogenesis of SLE is undisputed. B cells make autoantibodies, present self-antigens, secrete and respond to cytokines and chemokines, and can regulate the function of other immune cells [1-2]. Because of these characteristics, selected subsets of B cells have been targeted for depletion in SLE, as possible therapeutic means. Below we list the biologics used to this goal, with an overview of their action and activity in clinical trials.
CD20 is expressed on immature and mature B cells, but not on plasma cells. The function and natural ligand(s) of CD20 are currently unknown, although it has been suggested that this molecule might be involved in B cell activation by influencing Ca++ influx across the plasma membranes [3].
Ocrelizumab is a humanized (90%) anti-CD20 monoclonal antibody that targets mature B cells. It was investigated in two phase III, randomized, double blind, placebo-controlled, multicenter studies, one in patients with lupus nephritis (BELONG) (Study ID ClinicalTrials.gov Identifier: NCT00626197), and another study that evaluated two doses of ocrelizumab in patients with active SLE (BEGIN) (Study ID ClinicalTrials.gov Identifier: NCT00539838). These trails have recently been suspended due to the detection of serious and opportunistic infections [4].
Rituximab is a chimeric IgG1 monoclonal antibody that targets CD20. As such, it depletes immature, naïve, memory, and germinal center B cells, but spares pro-B cells, early pre-B cells and plasma cells [5]. It is made of murine light and heavy chain variable regions and a human constant region. The murine Fab domain binds CD20, and the human Fc domain can cause B cell lysis by ADCC and apoptosis [6]. Since rituximab does not reduce significantly the levels of circulating antibodies [7-8], it also does not decrease titers of circulating autoantibodies.
Rituximab was initially approved for the treatment of low-grade non-Hodgkin B-cell lymphomas. After its success in that context, the use of rituximab was tested in autoimmunity in RA, where it showed positive effects in combination therapy with methotrexate or cyclophosphamide [9].
In SLE, rituximab has shown efficacy in case series and in open studies [10-14]. Several clinical trials with rituximab have been done in SLE (ClinicalTrials. gov Identifier: NCT00036491; NCT00278538; NCT00282347; NCT00293072; NCT00556192; NCT00908986). Studies have also addressed the effects of hematopoietic stem cell transplant post-rituximab treatment in SLE patients (ClinicalTrials. gov Identifier: NCT00230035; NCT00726518) or the safety and efficacy of the use of rituximab in combination therapy (e.g. with cyclophosphamide or mycophenolate mofetil in lupus nephritis; EXPLORER and VOYAGER [a phase II/III extension study to evaluate safety of rituximab retreatment in subjects with moderate to severe SLE]) (ClinicalTrials. gov Identifier: NCT00137969; NCT00381810).
In patients with refractory SLE treated with rituximab and cyclophosphamide, improvement or clinical remission lasting for a mean of three years in a third of the patients has been observed [13-14]. Also, a phase I/II prospective open-label study that followed 24 patients with active lupus refractory to conventional immunosuppressant found that one fourth of the patients had B-cell return to baseline at 24 weeks, and one third developed human anti-chimeric antibody which correlated with poor B-cell depletion [15] - a concern related to the fact that this agent is not fully human. The maximum therapeutic effects of rituximab in SLE seemed to occur at or after twelve weeks, although B-cell depletion from peripheral blood was rapid and variable from two to eighteen months [7, 16]. Apparently, this biologic might be effective in severe SLE refractory to conventional treatment and might possibly provide benefits to subgroups of SLE patients [7, 17-18].
Both the 52 week-long EXPLORER (257 patients) and the LUNAR (144 patients) trials with rituximab (the first one in non-renal SLE and the second one in proliferative lupus nephritis patients) did not meet their primary endpoints of achieving a complete or partial response after 52 weeks [19-20]. In the EXPLORER trial [19], the proportion of patients who had a major clinical response defined as no severe flare up to week 24 and no moderate or severe flare to week 52 was similar between the rituximab group (12.4%) and the placebo group (15.9%), as well as the proportion who had a partial clinical response (17.2% versus 12.5%, respectively). In the LUNAR trial [20], there was not a statistically significant difference between rituximab-treated patients and controls, although at 52 weeks 57% of patients in the rituximab group had a renal response versus only 45.9% in the placebo group. Also the secondary endpoints were not met (for the EXPLORER trial: major or minor clinical response at week 52, the achievement of improved British Isles Lupus Assessment Group (BILAG) score at week 24, time to moderate or severe flare over 52 weeks, change in Short Form (SF)-36 Health Survey from baseline at week 52, and a major clinical response with less than 10 mg daily prednisone from week 24 to 52; for the LUNAR trial: drop of urine protein-to-creatinine ratio from greater than 3 at baseline to less than 1 at week 52, time to first complete renal response, change from baseline in the SF-36 Physical Functioning score, and time-adjusted area under the curve minus baseline of the BILAG index global score). Interestingly, however, subgroup analyses in the EXPLORER trial showed that black and Hispanic patients treated with rituximab had a statistically significant improvement in the primary endpoints (but not in the secondary endpoints). Methotrexate-treated patients also did statistically significantly better with rituximab In the LUNAR trial, non statistically significant data showed that in the subgroup of black patients, 70.0% of who received rituximab had a response compared with 45.0% of those who received placebo. For Hispanic patients, the response rates were 55.0% with rituximab and 47.8% with placebo.
Recently, the analysis of prospective data on rituximab treatment in a cohort of 136 SLE patients from the French Autoimmune and Rituximab Registry that were followed for about 18 months showed a significant reduction of SLEDAI score at six months and less severe infection than the EXPLORER study [21].
Notwithstanding these considerations, caution may be required in using rituximab for the risk of severe acute infection and the reactivation of latent infection, such as of JC virus, which causes progressive multi-focal leukoencephalopathy (PML) [22]. For example, deaths from PML in SLE patients treated with rituximab and PML after rituximab therapy in patients with hematologic malignancies under immunosuppressive drugs (e.g.: chemotherapy, stem cell transplant) have been reported [22-23], although it must be acknowledged that PML may a concern for SLE patients independently of rituximab therapy.
TRU-015 is a single chain polypeptide comprising one binding domain, one hinge domain and one effector domain. TRU-015 has potent ADCC activity and targets CD20 to deplete B cells. A randomized study assessing safety, pharmacokinetics and pharmacodynamics of TRU-015 added to standard therapy in patients with membranous lupus nephropathy (Study ID ClinicalTrials.gov Identifier: NCT00479622) has been terminated, mainly because of its similarity to the ongoing phase I clinical trial on safety, pharmacokinetics and pharmacodynamics of SBI-087 (another fully humanized anti-CD20 that temporarily depletes B cells) in SLE patients (ClinicalTrials.gov Identifier: NCT00714116) that showed good safety and tolerabilty in subjects with controlled SLE [24].
CD22 is an adhesion molecule that regulates B cell responses through the recruitment of key signaling molecules to the B cell receptor complex. CD22 has an important role in B cell development, survival and, interestingly, can exert both stimulatory and inhibitory effects on B-cell signaling [25]. Differently from CD20 - that is expressed from the pre-B-cell to the activated B-cell stage - CD22 is only expressed in mature B cells and disappears upon their differentiation into plasma cells [26].
Epratuzumab is a fully humanized, little immunogenic antibody to CD22. Epratuzumab negatively regulates hyperactive B cells by inhibiting B cell receptor signaling and by inducing the internalization of CD22 [27]. Epratuzumab also causes a 30-45% reduction of B cell numbers [28-29] but it does not affect significantly the titers of circulating autoantibodies [28, 30]. The safety and pharmacokinetics of epratuzumab in SLE have been reported (ClinicalTrials. gov Identifier: NCT00383214; NCT00111306; NCT00113971), and a phase III clinical trial on the long-term use in SLE is ongoing (ClinicalTrials.gov Identifier: NCT00383513). A phase II trial addressing dose response and frequency (ClinicalTrials. gov Identifier: NCT00624351) recently showed a relatively rapid reduction in disease activity in some patients with moderate to severe active disease [31].
B-lymphocyte stimulator (BLyS, also known as B cell activating factor BAFF, TALL-1, THANK, zTNF4) is a member of the TNF family that is essential for the development, homeostasis, proliferation, survival and differentiation of B cells into mature plasma cells. Expressed as transmembrane protein on monocytes, dendritic cells and activated T cells, or released as a soluble molecule, BLyS binds to its receptors expressed on activated B cells. There are three receptors for BLyS: B-cell-activating factor receptor (BAFF-R, BR3), transmembrane activator and calcium modulator and cyclophylin ligand interactor (TACI), and B cell maturation antigen (BCMA). These receptors are present mainly on mature B cells, with TACI being expressed predominantly on CD27+ memory B cells and BCMA on plasma blasts, plasma cells, and tonsillar germinal center B cells, and BAFF-R on all peripheral B cells (in which it promotes cell survival, similarly to BCMA that also inhibits apoptosis). The stimulation of all three receptors increases nuclear factor- κB (NF- κB), which promotes cell differentiation and proliferation.
BLyS hyperproduction associates with autoimmune diseases including murine SLE [32], and its serum levels are elevated in lupus patients and correlate with autoantibody titers [33-34]. Of interest, the levels of serum BLyS increase after B cell depletion therapy with rituximab [35-37].
Belimumab is a fully human IgG1 that specifically binds to BLyS, inhibiting BLyS's stimulation of B cell development and restoring apoptosis in autoantibody-secreting B cells. After phase I trials that showed tolerability, immunogenicity, and pharmacology of belimumab in mild to moderate SLE patients (ClinicalTrials.gov Identifier: NCT00657007), phase II studies failed to meet their endpoints (ClinicalTrials.gov Identifier: NCT00071487). However, as these studies showed an improvement in SLE disease activity measures and serological improvement in serologically active patients [38], to further address the long term efficacy and safety of belimumab in SLE patients, two phase III double-blind, placebo controlled, multi-center superiority trials were initiated in seropositive patients (ClinicalTrials.gov Identifier: NCT00424476; NCT00410384). The two studies, which represent the largest clinical trial programs ever conducted in SLE, had similar design but a difference of duration therapy and location/recruitment sites: 52 weeks with 865 patients at 90 clinical sites in Asia, South America and Eastern Europe for "BLISS-52", and 76 weeks with 826 patients at 133 clinical sites in North America and Europe for "BLISS-76". The primary efficacy endpoint were based on the new SLE Responder Index, which takes into account a reduction from baseline of SELENA SLEDAI and BILAG scores and the physician global assessment, these parameters being analyzed on intention-to-treat (ITT) adjusted for baseline stratification factors including the SELENA SLEDAI score, proteinuria and race. In each of the two trials, patients were randomized to two doses of belimumab (1mg/kg and 10 mg/kg) and received the biologic agent i.v. on day 0, 14, 28, and then every 28 day for the entire duration of the study, together with standard care therapy. Overall, a statistically significant improvement versus the placebo group was observed in both trials at the 52 weeks time point. There was a delay of the time to first flare, a reduction of disease activity, reduced need for steroid use, and reduced fatigue and better quality of life for the SLE patients treated with belimumab [39]. The results at 76 weeks from the BLISS-76 study showed higher response rates compared with placebo plus standard of care; however, this secondary endpoint did not reach statistical significance [40].
A-623 is a fusion polypeptide consisting of a BLyS binding domain fused to the N-terminus of the Fc region of a human antibody. A-623 binds to BLyS and inhibits the interaction of BLyS with its receptors. Based on the positive results in phase Ia and Ib clinical studies, a phase IIb clinical study using subcutaneous administration of A-623 or placebo plus standard of care is currently enrolling serologically active lupus patients.
Briobacept is a homodimeric recombinant fusion glycoprotein of the extracellular ligand-binding portion of BAFF-R and the Fc portion of an IgG1. It blocks circulating BLyS, thus inhibiting B cell activation and promoting B cell apoptosis. Preclinical studies showed effectiveness of briobacept in reducing B cells in vivo [41], which was confirmed by the finding of a 55% reduction in peripheral B cells in clinical trials in RA patients. While preliminary, these data suggest possible therapeutic activities of briobacept in SLE.
APRIL, also known as TALL-2, TRDL-1 and TNFSF13A, is another member of the TNF-ligand superfamily that, unlike BLyS, only functions as a soluble factor. APRIL binds to BCMA and TACI, but not to BAFF-R. Although APRIL alone has little effects on B cells, together with BLyS can form circulating BLyS/APRIL heterotrimers (BAHTS) with BLyS-like activity [42].
Atacicept is a recombinant fusion protein made of the extracellular portion of TACI fused to the Fc of a human IgG. It blocks the activation of TACI by APRIL and BLyS. The efficacy and safety of atacicept in combination with mycophenolate mofetil to treat lupus nephritis has been evaluated in a randomized, double-blind, placebo-controlled phase II/III trial with primary outcome measures an improvement in renal response to treatment at 52 weeks (ClinicalTrials.gov Identifier: NCT00573157). Another phase II/III trial in generalized SLE that evaluates the use and effective dose of atacicept compared to placebo in reducing numbers of flares in SLE patients is ongoing (ClinicalTrials.gov Identifier: NCT00624338).
In certain autoimmune diseases, the use of biologics is providing an enormous contribution to disease stabilization and the prevention of complications. Compared to the use of biologics in RA, the use of biologics in SLE has been slower, likely due to the differences in the pathogenesis of the two diseases and the inter-individual variety of manifestations and therapeutic needs in SLE patients.
Despite the relative novelty in the use of biologics in SLE, the field is showing promise, and new investigations are fueled by the encouraging results from recent clinical trials. The hope is to possibly find new drugs that can be partly devoid of the significant side effects that characterize the use of immunosuppressive drugs - widely used in the disease management - while providing effectiveness in inducing disease remission or in reducing disease activity. More specificity of action, a targeted use, and improved efficacy, are the major goals expected for new drugs that might be approved for the treatment of SLE in a near future.
Another consideration is that the critical evaluation of the failures of past clinical trials has been somehow instrumental in improving the design of newer trials. One example is the selection of seropositive SLE patients in the benlysta phase III trials after the negative results of the phase II studies.
Additional aspects improving trial design have included and will include the use of better instruments for the measurement of outcomes, better selection of endpoints, pre-identification of possible responders and subsetting of patients with common characteristics, choice of disease status and duration at enrollment, organ involvement, concomitant therapy, and possibly even consideration on the genetic backgrounds. Timing of response, bioavailability and duration of effects, in addition to best dosing to avoid side effects, should be the additional parameters to take into account. Statistical power has also frequently been a problem due to the clinical diversity of SLE patients, and trials with large numbers of patients may be required to obtain meaningful information. Ultimately, the goal is to find new targeted effective therapies in SLE that may allow a better clinical management, a more favorable prognosis, and an improved quality of life for SLE patients.
Declaration of interest: A La Cava is supported by grants from the National Institutes of Health and the Arthritis Foundation Southern California Chapter.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Red Bull Sound Select presents:
Pell - Patience (Chris Lake Remix)
Billboard who? Everybody knows that the only charts that really matter are the DJBooth Top 20s. You can always find out which songs were the week's most popular, but why only use those eyes when you've also got those beautiful ears. Now, you can hear which songs are burning up The DJBooth with the playlist version of our Top 20 Hip Hop / R&B chart; as an added bonus, we've included two "Next Up" tracks that just missed making the Top 20. Lil Wayne takes the top spot with the help of Drake. Big K.R.I.T, DJ Khaled and Michael Jackson all make as well.
View the full Top Hip Hop / R&B Chart.


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The President-elect will be scaling back the Missile Defense Shield (popularly known as Star Wars), but will not do away with it entirely. Congressional committees will likely scale back the Missile Defense Agency, but thankfully, we're keeping our blasters on our hips, not throwing them in the cargo bay.
According to CQ:
"I think it's unlikely you'll see MDA in its current form after next year. It's going to be downgraded," said one Democratic committee aide. "MDA needs to stop doing everything, and they need to go back to their core mission."
What is that core mission? Shooting enemy missiles out of the sky! Even scaled back, it's still pretty awesome. It's a lot like this. I for one am glad we're still ready to throw down if need be. It's just too bad the Mavericks didn't make it into the big house. We'd have way more and way more deadly missiles to protect us. They'd probably fire out rabid badgers at our enemies or something. Justice.
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Nobex MultiFix Angle Gauge
The Nobex MultiFix is a combination protractor and sliding T-bevel which allows you to measure any corner and transfer the correct miter angle directly to your miter saw.
Measure inside or outside angles (over the range of 70° to 180°), quickly know the bisecting angle for any miter joint. Made in Sweden.
Notice to residents of California: Please read our Proposition 65 warning.