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Published: June 30, 2011
Snoopy was adopted in February 2000 from the Mahoning County Dog Pound by Jo Niles and Tim Niles of Boardman. She was 8 weeks at the time; she died in March of this year.
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UberAudio is a free, open-source extension of Unity's audio system. It organises all your audio into banks, rather than scenes or prefabs, and audio is triggered through a flexible, loosely coupled interface.
Although rewritten for Unity, this is the same system we used on Dungeon Keeper and Fable.
Core Features
- Audio banks. Edit and organise all your audio without modifying any scenes. Mount them into your scenes at runtime.
- Flexible audio triggers. Audio is triggered in code via audio event triggers. "AudioManager.Instance.Play("Shot");" will look through the mounted audio banks and only trigger some audio if a match is found.
- Audio event trigger specialisation. Audio events can be given increasing levels of specialisation - "Wolf:Footstep" is more specialised than "Footstep". If a specialised event isn't found, UberAudio will remove specialisations until it finds a match - this allows a coder to programmatically fire off lots of events, and an audio designer to honour only the ones he cares about.
- Improved lifetime management. By default, your audio won't die immediately when the GameObject it's attached to dies - audio cutting rarely sounds good. Similarly, if you've got a looping sound the sound will release it's loop on death, and then stop naturally.
- Randomness and weightings. Multiple audio events with the same name are treated as a group, and triggering such an event will automatically pick a random audio event from the group. Individual events can be given higher or lower random weighting within their group.
- Lightweight. UberAudio is a simple wrapper around Unity's audio system, and at any time you can get access to the AudioSource you're using.
Quick Start Guide
- Add the Audio Manager to your scene through Assets->UberAudio->Create Audio Manager.
- Create an Audio Bank through Assets->UberAudio->Create Audio Bank. Make sure you create it in a resources folder so it can be loaded dynamically.
- Click on the new audio bank and add some audio events to it.
- Mount your audio bank in your scene: Assets->Uber Audio->Audio Bank Mounter. Change the bank path to the path of your audio bank.
- In code, trigger an audio event through AudioManager.Instance.Play("YourEventName"). If you want to trigger a 3D sound, attach your audio to a game object through AudioManager.Instance.Play("YourEventName", gameObjectToTrack).
- If you have problems, tick some of the debug options on your AudioManager object - 'Log Bank Loads' and 'Log Event Lookups' are usually very helpful.
There's also an example project that shows you how to use things.
Audio Events and Banks
An 'audio event' is a unit of audio which can be triggered through AudioManager.Instance.Play(). Audio events are created and stored in 'audio banks', which are mounted in your scene through an AudioBankMounter.
There are various advantages to organising things in banks:
- Audio can be added, changed, removed without touching any scenes. This means you can have your audio designer can work independently.
- Similarly, game code can be written without explicitly touching audio sources.
- You can edit all your audio in one place, and group together pieces of related audio into the same bank.
- And audio clip can be reused multiple times with different settings.
- You can mount or unmount audio banks on demand.
- Moreover, because of the flexible trigger system UberAudio uses, when you mount a new bank any new audio events that share the same triggers as existing events are automatically grouped. This means you can keep an audio bank in memory with a single version of a sound, and then load/unload banks containing variations on demand - a handy memory saving trick.
Audio Event Triggers
To trigger an audio event in a bank you simply call 'AudioManager.Instance.Play()' with the name of the event you want to trigger. If such a trigger isn't found, nothing is played.
In addition, event triggers can be specialised. An example helps to explain how this workds and why it's useful.
Imagine a game in which you have lots of different creature types, each with their own type name stored in 'CreatureName', and you want to give one of them a unique footstep sound. Obviously, using the normal event triggers, you could fire off an audio event trigger of 'CreatureName+"Footstep"'. However, that would mean creating a new trigger in your bank for all of your creatures, with most of them having the same settings. This is clearly inefficient.
Trigger specialisation solves this common problbem. In your audio bank you create two audio events, one for the general case and one for your special case - so "Footstep" and "Wolf:Footstep". In code you fire off 'CreatureName + ":" + "Footstep" - the ':' is a special seperation marker.
Now, when CreatureName is 'Wolf' we'll have an event trigger of 'Wolf:Footstep and there's an exact match for that, which will be played. However, when you fire off "Goblin:Footstep", it won't find anything; it then strips off the first specialisation on the left ('Goblin' in this case), and tries again, this time finding Footstep. Footstep is played, giving you a default sound.
This system works for any number of specialisations, working from left to right. Thus things 'Wolf:Gravel:Footstep' might be used if you have different sounds for ground materials.
This is a very handy workflow. It means coders can programmatically fire off very specific events to the audio system, and audio designers can quickly create defaults for the most common cases and create more specialised versions when needed.
Incidentally, obviously using ':' directly in code is horrible; AudioManager.MakeEvent() exists to make audio specialisation events. Thus the above would look like 'AudioManager.MakeEvent("Wolf", "Gravel", "Footstep")'.
Audio Event Trigger Groups
Multiple event triggers with the same name are automatically grouped together in UberAudio, creating a trigger group. When an audio event trigger from a group is played, it will pick a random entry from the group. By default, all events are given the same weighting in the randomisation, but if you wish you can weight a given event higher or lower by changing its weighting in the audio bank.
This allows audio designers to create variations for audio quickly and easily.
Audio Event Liftime
When you fire off an audio event in UberAudio, if you want a 3D sound the second parameter to Play needs to be a GameObject. Any audio triggered by your event then tracks the position and lifetime of that GameObject.
Unlike raw AudioSource playback in Unity, however, by default your audio will not immediately die as soon as the GameObject it's attached to dies - this is rarely desireable. Instead, it will finish its playback and then die; if it's a looping sound, it will release it's loop and then die.
This behaviour can be overridden in the properties mask of an event in the audio bank.
Editing Audio Banks
Editing audio banks is fairly simple. Below is a screenshot of what it looks like:
From left to right, we've got:
- The drag handle. Use this to move audio event groups around.
- A foldout arrow. As you can see at the bottom of the picture, opening it up gives you access to the normal Unity audio source editor, where you can adjust things as normal.
- 'T' and 'R' stand for 'play This sound' and 'play Random sound'. The former plays this event, using the parameters your set up; the latter, chooses a random event from the group, using the weighting parameters you've set up.
- Next along is the event trigger name. Events with the same trigger name will automatically be grouped together.
- Next is the audio clip.
- Next is the random weighting. This can be any number, and is relative to the other weights in the group - thus if you have two events, one with a weight of 1 and the other 3, the first event has a 1 in 4 chance of playing.
- Next is the properties mask. Options here are
- 'Loop'. Makes the audio source loop.
- 'Stop playing immediately when source dies'. This makes the audio event cut off when the GameObject it's attached to dies.
- 'Keep looping when when source dies'. By default looping sounds release their loop when their source dies, and this stops that. Be careful - UberAudio won't be able to kill this audio event for you.
- Do not track source position. Use this if you want an event to be fired off at the source objects position, and to track the lifetime of the source object, but you want it to stay still. Useful for things like footsteps.
- 'Dl'. Deletes an event.
- 'Cl'. Clones an event.
- Stick the UberAudio folder somewhere under your Unity project Assets folder.
- Create and audio bank via Assets->UberAudio->Create UberAudio Bank.
- Usage examples can be seen in the Examples folder.
- Requires Unity 5.1
Pull requests welcome!

subset: commoncrawl


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by Sharon Rondeau
(Feb. 16, 2017) — Various outlets have reported that President Donald Trump will hold a press conference at 12:30 p.m. EST Thursday in the East Room of the White House.
According to Fox News, Trump will take questions from reporters.
The Post & Email has not seen, as of press time, the topic of the presser, but it can be reasonably expected to include intelligence leaks which appear to have begun after Trump spoke with Australian Prime Minister Malcolm Turnbull on February 1, when the contents of an apparently at-times contentious conversation were divulged.
On Thursday morning, Trump stated that "We're going to find the leakers" and prosecute them, repeating his assertion made on Wednesday during a presser with Israeli Prime Minister Benjamin Netanyahu.
On Wednesday evening, The Wall Street Journal reported that unnamed intelligence agents are reticent to share "sources and methods" used to gather information from around the world with the Trump administration. On Thursday at 12:02 p.m., Catherine Herridge of Fox News reported that the Office of the Director of National Intelligence (ODNI) has denied the claim.
Some suspect that "Obama holdovers" leaked contents of the Turnbull call and telephone calls made between former National Security Advisor Michael Flynn and the Russian ambassador in late December. On Monday night, Flynn was forced to resign given reports which were said to reveal that he misrepresented the substance of his calls with Vice President Mike Pence.
As The Post & Email reported earlier, the media claims that the White House is in "crisis mode."
For decades, Trump has harbored a distrust of the mainstream media based on what he says is "dishonest" reporting. On Thursday morning, he tweeted, "…they are fading fast!"
Trump is reportedly seeking to hire an outside consultant to probe and determine the source(s) of the intelligence leaks.


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Results 1 to 2 of 2
11-07-10, 01:25 #1Registered User
- Join Date
- Nov 2010
- Posts
- 1
creating ERD of dynamic user interface
please tell me how to create ERD for dynamic user interface .i am creating real estate web portal.in this user can create his own website and he can personalize and customize the appearance of his website.how do i make the database of such a scenario.how the look and feel of each user personal page will be stored in a database.can anyone tell me how to create ERD i-e which tables will be created and which information will stored in a database related to look and feel.
11-07-10, 11:10 #2Resident Curmudgeon
- Join Date
- Feb 2004
- Location
- In front of the computer
- Posts
- 15,579
Just determine which tables you need and their relationships, then create an ERD for that.
-PatPIn theory, theory and practice are identical. In practice, theory and practice are unrelated.


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The first of 6 new Krispy Kremes in N.J. is opening this week
Hot Doughnuts Now in Jersey City! Krispy Kreme will open its long-awaited Jersey City shop at 5 a.m. Tuesday. The store, at 95 Christopher Coiumbus Dr., is the first of six planned Krispy Kreme locations in Bergen and Hudson counties by the franchisees, Entrepreneurs, LLC. Phone calls and e-mails to the franchisees and Krispy Kreme headquarters…


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View other listings in Kangaroo Point, Fortitude Valley, West End, Brisbane City.
Online about 1 year ago
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I am a steady professional. I am very quiet, but can be a socialite too. I have many travel stories and can speak several languages. I am a good listener and generally caring person.


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To the motorsports commenter (indycarseries500, to be exact) who thought my comment earlier in the day was a dumb comment…who the hell died and made you god of the comment section?
Archive for the 'random thought' Tag
Random Thought, 3 November 2014 Leave a comment
Random Thought, 30 October 2014 Leave a comment
…to the person on Twitter who thought it was cute to tell me to stop posting musical tweets….who the hell died and made you Twitter God?
Random Thought, 5 August 2014 1 comment
Is it just me or is this Behr Deck-Over paint commercial from the Home Depot just really, really stupid?
Random Thought, 9 May 2014 Leave a comment
Maybe its' just me, but its' still shocking to see NBCSN's resident F1 tech major-domo, Steve Matchett, doing commentary at a car auction…then again, it could be worse: he could still be over at
Speed Channel Fox Sports 1.
Random Thought, 7 May 2014 Leave a comment
If I had a dime for every tinpot, crackhorn conspiracy theory – like this one – in regards to the Obama Administration, I'd be a millionaire by now.
Random Thought, 20 April 2014 Leave a comment
My view on the topic of alternate history – if it could be boiled down into one concise thought – is this: why concern myself over the 'what ifs?' of history when actual history is so damned much more interesting; if it offends anyone, oh, well..
Random Thought, 10 April 2014 1 comment
To the person on Twitter who just told me to "shut up" in response to a song tweet I posted while listening to Pandora….
I'll post what I damn well want to, within the bounds of reason and politeness…don't like what I post, don't follow me.
Any questions?


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My live as a traveller starts on August 2, 2003...
As a little boy I always had the dream to build my own sailing boat and sail around the world. Now I was 24 and had studied and worked for about 7 year as a yacht builder. I liked my job, but there was still something missing, the adventure. I wanted more adventure in my live, I wanted to see more of the world. But I also had a good job which I liked and I had plans to go for floor-manager in the company I worked for.
However I really like to travel, it wasn´t an easy decision to quit my job and to go on a journey of 11 months through Latin America.
About the consequences of this decision, the places I´ve been and the things I´ve done, you can read in the stories below, one thing is for sure; I´ve never regret my decision.
I first wrote my stories in Dutch and later translated them into English. Especially within my first stories you will notice that I´m not only practising my Spanish during this trip, but also my English needs to improve a lot. I hope this is not too disturbing and I really hope you like to read about my experiences and maybe they can convince you to go travelling as well...
On request of some other travellers who were curious after my future experience, I´ve decided to try to write an English travel report also.
My journey started on 2-8-2003 at Mexico City, with a strange feeling in my stomach. I was exited; my journey had finally begun, but also a little afraid. The next 11 months i would be al on my own and when I will return, I´m not even sure if will get my job back?
Ok, don´t worry and don´t think about it.
Mexico City, a big dirty city with, during the day, a lot of things to see and do, but before and after I felt it a stinky, dirty and boring city. But maybe you have to know where to go? My best experience were; meeting other travellers, seeing Teotihuacan and travelling with, I think, the cheapest and fastest subway in the world. My worst experience were; getting serious ribbed off (we needed to pay much too much at a bar), stomach problems on the 3e day (food?) and running in the ¨fresh¨ morning air of the city....
Up to Oaxaca. A friendly town with lots of things around to see. Of course you can go to the ruins of Monte Alban, but I will also recommend to go to Apoalla, a very small village nearby and to stay there for at least one night between the rocks and nearby a beautiful waterfall, before you go back to Oaxaca!
A lot of people I met in Oaxaca came from or went to Porto Escondino, so I decided to go there too. Although there were 2 nice beaches surrounded by rocks, the main beaches and the village were not very special. I think this is only a nice place to go to if you can surf and if you don´t stay in hostel Shalon.
Following the advice of other travellers, I went up to Manzute. I felt immediately at home! Beautiful surrounding, beaches, hospitable atmosphere, some friendly travellers and not (yet) too many travellers, I hope it stays like that???? After three days I had to say goodbye, a little sad, but too much time doing nothing is not good for my.
Now I´m sitting in Tuxla and ask myself why? The city is not that bad, but everything I wanted to visit today was closed or half closed. I hope the Canyon is still open tomorrow????


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Late 19th century Arts & Crafts oak dresser
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late 19th century Arts & Crafts oak dresser with Delft rack, having a moulded cornice above a series of shelves flanked by stylised carvings, the base fitted with a series of drawers and cupboards with brass drop handles and hinges also flanked by stylised carvings and raised on moulded spade feet 80"w x 15"d x 80"h
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At Silentnight, we know the secret to a great night's sleep
You have the total reassurance of knowing you are choosing a quality product from the UK's biggest bed manufacturer with 70 years of bed making heritage
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There are no short cuts to quality and safety, we guarantee total quality as standard.
We are proud to be the UK's most trusted bed brand. Most trusted bed brand - independent survey
All our upholstered beds and mattresses come with our reassuring product guarantee.


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Sparkle World® Magazine
Join all the best loved characters including Rainbow Magic, My Little Pony, Strawberry Shortcake, Littlest Pet Shop, Goblin Princess, Care Bears, and many more, for lots of fun, laughter, and play!
Designed to encourage early learning skills, each fun-packed issue includes:
• Delightful stories featuring the most popular characters around
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• 10 page workbook plus FREE stickers!
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Welfare Reform - What's Changing in Northern Ireland
The Welfare Reform Act is introducing a range of changes to the benefits system in Northern Ireland.
Many current benefits are going to be abolished and replaced by a new benefits system.
Universal Credit will replace many existing benefits
Universal Credit is a new single benefit for working-age people. From 2017 it will gradually replace most means-tested benefits such as income-based Jobseeker's Allowance, income-related Employment and Support Allowance, tax credits and Housing Benefit.
Personal Independence Payment will replace Disability Living Allowance
Personal Independence Payment (PIP) will gradually replace Disability Living Allowance (DLA) for people of working age with daily care needs or difficulty getting about. From 20 June 2016 if you make a fresh claim or report a change of circumstances you will be assessed for PIP. If you are of working age and have an existing indefinite award of DLA you will be contacted to be reassessed for PIP in December 2016 at the earliest. Not everyone who gets DLA will be able to get PIP in future, but if you lose your award or are paid a lower amount of PIP, you may be able to get a supplementary payment for a year to compensate you for your financial loss.
Cuts to Housing Benefit if your social housing is too large
If you live in social housing, such as Housing Executive or housing association accommodation, your Housing Benefit may be cut. This will only apply if you're of working age and you have more bedrooms than you're allowed after the new rules come in. If you are affected you will be given a supplementary payment so that you will not be financially worse off.
Employment and Support Allowance
From 31 October 2016 a time-limit has been set on claims for contribution-based Employment and Support Allowance for people in the work-related activity group. If you are in this group and have been getting contribution-based ESA for 365 days, you will no longer be eligible. If you are in the support group you will not be affected.
If you are affected you may be able to get supplementary payments for one year to make up for any financial loss.
The special conditions for Employment and Support Allowance for young people were abolished in February 2016.
Benefit Cap
From 31 May 2016 there is a cap on the total amount of benefit you can get. To begin with, the cap may affect you if you're getting Housing Benefit and could mean you will get less money towards your rent. If you are affected you may be entitled to financial help.
Benefit appeal rights will change
From 23 May 2016 if you don't agree with a social security benefit decision you must ask for it to be reviewed before you can appeal the decision. This change applies to all decisions made on or after this date.
The rules for disputing a decision will be explained in your benefit decision notification. If you think a decision is wrong, you can ask for it to be looked at again for any reason. This is known as mandatory reconsideration.
Changes to the Social Fund
In November 2016 there will be a change in how some Social Fund payments will be made. Crisis loans and community care grants will become part of a new Discretionary Support Payment scheme.
Will you get less money under welfare reform?
If you're worried that the benefit changes will reduce the money you have coming in, it's a good idea to start thinking ahead. For example, you could get a benefits check on your current entitlement and see whether there will be any transitional protection available. You could also get some advice about budgeting.
- For more information about the benefits changes, who will be affected and how to plan ahead, go to our new section on Welfare benefits reform
Other useful information
- More about welfare reform on the nidirect website www.nidirect.gov.uk


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Within hibernating myocardium, it is uncertain whether a normal energetic state is present at baseline and whether maintaining that energy state during a catecholamine challenge is dependent on ATP-dependent potassium channel opening. In this study, 16 swine underwent a thoracotomy with placement of an external constrictor on the left anterior descending coronary artery (LAD) (hibernation model). Seven additional swine underwent a sham operation. At 10 wk, the myocardial energetic state in the LAD region was assessed by 31P-NMR spectroscopy, and the ratio of phosphocreatine to ATP (PCr/ATP) was determined at baseline, during glibenclamide treatment (0.5 mg/kg bolus with 50 μg/min iv), and during addition of dobutamine (40 μg·kg−1·min−1 iv). At baseline, transmural blood flow in the LAD and remote region was 0.75 ± 0.11 and 0.88 ± 0.09 ml·min−1·g−1, respectively (P < 0.01), in hibernating hearts and 0.83 ± 0.12 and 0.88 ± 0.15 ml·min−1·g−1, respectively (not significant), in sham-operated hearts. Under basal conditions, PCr/ATP in the LAD region of hibernating and sham pigs was 2.15 ± 0.04 and 2.11 ± 0.05, respectively (not significant). In sham pigs, addition of dobutamine to glibenclamide increased the double product from 10.4 ± 0.8 to 23.9 ± 4.0 mmHg·beats·min−1 × 1,000 (P < 0.05) and decreased transmural PCr/ATP from 2.06 ± 0.06 to 1.69 ± 0.06 (P < 0.05). Dobutamine increased the double product in hibernating pigs in a similar fashion and, despite a 40% lower blood flow response, induced an equivalent decrease in PCr/ATP from 2.04 ± 0.04 to 1.73 ± 0.08 (P < 0.05). In conclusion, we found that, in chronic hibernating swine myocardium with reduced basal blood flow and perfusion reserve, the transmural energetic state, defined by PCr/ATP, is normal during addition of dobutamine, despite inhibition of ATP-dependent potassium channel opening with glibenclamide. These data suggest that important adaptations other than the ATP-dependent potassium channel opening allow hibernating myocardium to operate over a lower range of the oxygen supply-demand relationship to protect against myocardial ischemia.
- myocardial ischemia
- high-energy phosphates
- preconditioning
- hibernation
- mitochondrial adaptations
chronic hibernating myocardium has been observed both clinically and experimentally and is characterized by decreased regional blood flow and function at rest in the absence of significant necrosis (15, 18). Metabolically, hibernating myocardial tissue demonstrates increased glucose uptake and glycogen storage at a time that myocardial oxygen consumption is reduced and anaerobic glycolysis is not present (4, 5, 8). In chronically instrumented swine, hibernation evolves after several months of repetitive myocardial ischemia and can be distinguished from chronic stunning by a lower resting blood flow and decreased expression of sarcoplasmic reticulum calcium handling proteins related to contraction (1, 3, 11). Although the mechanisms of protection within hibernating myocardium are unclear, it is conceivable that ischemic preconditioning and hibernation share common signaling pathways that modify the severity of an energy supply-demand imbalance associated with limited perfusion reserve. Within ischemic preconditioned myocardium, ATP-dependent channel opening within the inner membrane of mitochondria may be protective by increasing the matrix volume and preserving the adenine nucleotide pool (2). Within the second window of protection, those channels on the sarcolemma may trigger downstream signaling that leads to cardioprotection (14).
Measurements of the phosphocreatine-to-ATP ratio (PCr/ATP) with 31P-NMR spectroscopy have been useful in predicting the severity of left ventricular (LV) dysfunction in patients with postinfarct remodeled hearts (19) and in identifying those patients with dilated cardiomyopathy who are at increased risk of cardiac death (13). Using 31P-NMR spectroscopy in the present study, we tested whether the transmural energetic state in a swine model of hibernation is normal under basal conditions and during inotropic stimulation. As observed in a swine model of short-term hibernation in which PCr/ATP improves at a time in which function and blood flow remain depressed (7), we postulated that high-energy nucleotides in chronic hibernation remain normal at high work states, despite inhibition of ATP-dependent potassium channel opening.
This study was approved by and performed under the guidance of The Animal Care Committee at the Veterans Affairs Medical Center and University of Minnesota and is in compliance with the Guide for the Care and Use of Laboratory Animals published by the National Institutes of Health (NIH publication 85-23, revised 1996).
Animal Preparation
Sixteen domestic pigs (8–10 kg) were used for the chronic ischemic pig model. They were sedated with xylazine (2 mg/kg im) and Telazol (4 mg/kg im), ventilated, and anesthetized with isoflurane (1%). The thorax was prepped and draped, and a left thoracotomy was performed in the fifth intercostal space. The left anterior descending coronary artery (LAD) was dissected free, and a C-shaped occluder (3 mm in length and 1.4 mm in internal diameter) was secured around the vessel and gently closed with suture (8, 9). Seven additional pigs (30 kg) also underwent a left thoracotomy with dissection of the LAD without instrumentation. In all animals, the pericardium and chest were closed in layers. Sterile dressings were applied, and a chest tube was placed and removed within 3 days of surgery. Cephazoline (1 g iv) was given before and 12 h after the procedure and repeated daily for 3 days. Pain prophylaxis was provided during the first 3 postoperative days with buprenex (0.5 mg im every 12 h).
Regional Function Measurements
Within 48 h of the final study, a two-dimensional (2D) echocardiogram was done during sedation to assess regional wall thickening. To determine the degree of contractile reserve in this hibernating model, wall thickening was also measured by 2D echocardiogram in six additional sedated swine not used for the terminal studies, at baseline and 5 min after an intravenous infusion of dobutamine (40 μg·kg−1·min−1). In these animals, wall thickening at baseline in the LAD and remote regions was 25 ± 5% and 37 ± 4%, respectively (P < 0.05). End-diastolic wall thickness at baseline in the LAD and remote regions was 9.4 ± 0.3 and 9.3 ± 0.4 mm, respectively (not significant), demonstrating no diastolic thinning. During dobutamine with an increased heart rate to 158 ± 18 beats/min, wall thickening increased slightly but significantly in the LAD region to 33 ± 8% (P < 0.05) but remained less than the increased wall thickening in the remote region, which was 48 ± 7% (P < 0.05). The heart rate increased from 58 ± 1 beats/min at baseline to 158 ± 18 beats/min with dobutamine infusion. These data confirm that functional reserve with dobutamine exists in the chronically ischemic LAD region but to a lesser degree than shown in remote regions.
31P-NMR Spectroscopy Technique
During the terminal study, pigs were sedated with Telazol (4 mg/kg im) and transferred to the Center for Magnetic Resonance Research at the University of Minnesota. Pigs were ventilated and anesthetized with pentobarbital sodium (30 mg/kg bolus followed by 4 mg·kg−1·h−1 infusion); after a midline sternotomy, animals were instrumented with a 31P-MR spectroscopy (MRS) coil on the anterior LV wall. Catheters were placed in the LV apex for administration of microspheres and in the left anterior descending coronary vein for sampling of substrate uptake.
Spatially localized 31P-NMR spectroscopy was performed with the use of the RAPP-ISIS/FSW method. This is the rotating-frame experiment that uses adiabatic plane-rotation pulses for phase modulation (RAPP)-imaging-selected in vivo spectroscopy (ISIS)/Fourier series window (FSW) method. In this application of RAPP-ISIS/FSW, the signal origin was first restricted to a 12 × 12-mm 2D column perpendicular to the LV wall. The signal was later localized into three well-resolved and five partially resolved layers along the column and hence across the LV wall. Localization along the column was based on B1 phase encoding and employed a nine-term FSW. Whole wall spectra were obtained with the ISIS technique, defining a column 12 mm2 perpendicular to the heart wall. The calibration of spectroscopic parameters was facilitated by placing a polyethylene capillary filled with 15 μl of 3 M phosphonoacetic acid into the inner diameter of the surface coil. This phosphonoacetic acid standard was used only for calculating the 90° pulse length of the RAPP-ISIS method. The position of the voxels relative to the coil was set according to the B1 strength at the coil center, which was experimentally determined in each case by measuring the 90° pulse length for the phosphonoacetic acid standard contained in the reference capillary at the coil center. NMR data acquisition was gated to the cardiac and respiratory cycles using the cardiac cycle as the master clock to drive both the respirator and the spectrometer as previously described (19). The surface coil was constructed from a single turn copper wire 25 mm in diameter with each side of the coil leads soldered to a 33-pF capacitor. Complete transmural data sets were obtained in 10-min time blocks using a repetition time of 6–7 s to allow for full relaxation for ATP and Pi and ∼95% relaxation of the PCr resonance. PCr/ATP results were calculated for each transmurally differentiated spectra set, and all resonance intensities were quantified using integration routines provided by SISCO software.
Calculation of free ADP levels.
Myocardial free ADP levels were calculated from the creatine kinase equilibrium expression (where Keq = 1.66 × 109, cytosolic pH = 7.1, and brackets indicate concentration): [ADP] = [ATP][CRfree]/[PCr][H+]Keq (19). PCr and ATP values obtained from the spectra were calibrated from chemically determined ATP levels measured from the tissue biopsy samples following the protocol. Free creatine was calculated by subtracting the PCr values from total creatine measured in the tissue.
1H-NMR spectroscopy technique.
Radiofrequency transmission and signal detection were performed with the dually tuned 28-mm-diameter surface coil. A single-pulse collection sequence with a frequency-selective Gaussian excitation pulse (1 ms) was used to selectively excite the N-δ proton resonance signal of the proximal histidine in deoxymyoglobin (12). This technique provided sufficient water suppression because of the large chemical shift difference between water and deoxymyoglobin (>14 kHz). Adjusting the radiofrequency pulse power with the water signal as a reference optimized the NMR signal. A short repetition time (25 ms) was used because of the short longitudinal relaxation time (T1) of deoxymyoglobin. Each spectrum was acquired in 5 min (10,000 free induction decays). Although the short T1 of deoxymyoglobin and fast acquisition prevent gating to the cardiac cycle, the signal loss due to motion is negligible compared with the inherently broad line width of the deoxymyoglobin peak.
Experimental Protocol
The regulation of oxidative phosphorylation was determined by MRS estimates of transmural PCr/ATP. Systolic blood pressure, heart rate, and rate-pressure double product were determined at each work state. Measurements were determined at baseline, during an intravenous infusion of glibenclamide (0.5 mg/kg bolus followed by 50 μg/min iv), at a dose that blocks the protective effect of ischemic preconditioning in swine (16), and during addition of dobutamine (40 μg·kg−1·min−1 iv) (Fig. 1). Regional myocardial blood flows were determined by standard blood flow techniques, using 1–2 million microspheres (15 μm) labeled with 141Ce, 85Sr, 46Sc, or 95Nb. Arterial-coronary venous lactate, glucose, and free fatty acid concentrations were determined by enzymatic technique, and oxygen saturation levels were calculated from arterial and venous blood-gas measurements. After the NMR study and before death, tissue from the LAD region was extracted with forceps and immediately frozen at −70°C for enzymatic assay of high-energy phosphates (8). The heart was then removed and separated into LAD and non-LAD regions, and the absence of necrosis was confirmed by placing longitudinal sections in freshly prepared triphenyltetrazolium solution. Heart tissue was then fixed for at least 48 h in 10% formalin, and myocardial and reference blood samples were counted in a multichannel analyzer (gamma counter 5000; Packard).
Data are expressed as means and SE. In the hibernating and sham pigs, regional blood flow and function at baseline were compared in the LAD and remote regions by paired Student's t-test. During repeated measurements, statistical differences were tested by ANOVA with post hoc testing using Student's paired t-test and a Bonferroni correction.
Baseline Metabolism in the Hibernating Model
Within 48 h of the terminal study, wall thickening was 27 ± 4% in the LAD region and 39 ± 4% in the remote region from the hibernating pigs (P = 0.01). At the time of the terminal study, regional blood flow by microspheres was 0.75 ± 0.11 ml·min−1·g−1 in the LAD region and 0.88 ± 0.09 ml·min−1·g−1 in the remote region from the hibernating pigs (P < 0.01). No differences in either regional function or blood flow were noted in the sham-operated pig hearts (Fig. 2). Baseline NMR spectra were obtained from the anterior wall of hibernating and sham pigs, and representative examples are shown in Fig. 3. At comparable levels of work during basal conditions, transmural PCr/ATP in hibernating and sham pigs was 2.15 ± 0.04 and 2.11 ± 0.05, respectively (not significant). Regional arterial-venous lactate uptake under basal conditions was 23.6 ± 8.3% in the hibernating pigs and 32.9 ± 8.8% in the sham pigs (Table 1), demonstrating no net differences in lactate production. Similarly, transmural myocardial oxygenation, by in vivo 1H-MRS myoglobin saturation levels, demonstrated no myoglobin desaturation in the hibernating myocardium (data not shown). Together, these metabolic findings demonstrate that hibernating myocardial tissue has adapted favorably so that myocardial ischemia is not observed, despite the presence of reduced wall thickening and depressed regional blood flow at baseline.
Bioenergetics During Increased Work in the Hibernating Model
To determine whether transmural energy is dependent on ATP-dependent potassium channel opening, glibenclamide was infused at a dose that is known to abolish ischemic preconditioning in swine (16). Consistent with its systemic effects on increasing glucose uptake, glibenclamide decreased plasma glucose levels from 8.1 ± 0.7 μmol/ml at baseline to 5.6 ± 0.8 μmol/ml (P < 0.05) in hibernating pigs (Table 1). Glibenclamide tended to decrease transmural PCr/ATP in the hibernating myocardium from 2.15 ± 0.04 to 2.04 ± 0.04 and in the sham-operated hearts from 2.11 ± 0.05 to 2.06 ± 0.06, but those differences did not reach statistical significance. In sham animals, the increase in cardiac work in response to dobutamine was associated with a 2.3-fold increase in transmural myocardial blood flow and PCr/ATP decreased to 1.69 ± 0.06. Although the increase in blood flow in response to dobutamine was 40% lower in LAD tissue of hibernating pigs than that in sham pigs, the decrease in PCr/ATP at the high work state was comparable (1.73 ± 0.08) (Fig. 4), with a similar relationship between increased cardiac work and decreased PCr/ATP in hibernating and sham pig hearts (Fig. 5). Thus the lower basal blood flow and reduced perfusion reserve in response to dobutamine did not result in greater depression of PCr/ATP in the hibernating myocardium. After the stress-inducing protocol was completed, the chemically determined ATP levels were 12.49 ± 0.71 μmol/g dry wt in the hibernating LAD region and 15.46 ± 0.27 μmol/g dry wt in the sham LAD region (P < 0.01). Total creatine and calculated free ADP levels in the hibernating regions were slightly but not significantly different from the sham regions (Table 1).
To address the effects of glibenclamide on the energetic response to dobutamine in sham pigs in the present study, we compared the response of dobutamine from the sham animals in the presence of glibenclamide with the response of dobutamine in historical sham pigs in the absence of glibenclamide (6). The dobutamine infusion increased the rate-pressure product over twofold in both groups of animals, and, as shown in Fig. 6, the magnitude of the effect on transmural PCr/ATP was similar.
Hibernating myocardium is characterized by decreased contractile function associated with a modest but significant decrease in blood flow. Furthermore, the contractile response to inotropic stimulation is blunted in hibernating regions, and this is associated with a subnormal increase in myocardial blood flow. The subnormal response of contractile function could be the result of insufficient energy production due to impaired oxygen delivery (blood flow) in the hibernating region or could represent inotropic hyporesponsiveness of the hibernating myocardium that acts to match contractile function to the limited blood supply. If contractile function is limited by insufficient oxidative ATP production, then free ADP levels will rise. In this situation, the creatine kinase reaction transfers a phosphoryl group from PCr to ADP in an attempt to maintain the ATP level, thereby resulting in a decrease in the PCr/ATP level. Thus examination of the response of PCr/ATP (which bears an inverse relation to cytosolic free ADP) will demonstrate whether the hyporesponsiveness in the hibernating region resulted from insufficient energy production or represents an equilibrium in which the contractile demands for energy are reduced in proportion to the decreased oxygen delivery (blood flow).
The principal finding of this study is that, in a swine model of hibernating myocardium with decreased regional blood flow and function at rest, the energetic state, as determined by PCr/ATP derived by 31P-NMR spectroscopy, was normal. The energetic state remained normal during a catecholamine-induced increase in cardiac work, despite a reduced blood flow response. Furthermore, the equilibrium between energy demands and blood flow was maintained in the presence of ATP-dependent potassium channel (KATP) blockade with glibenclamide. This is of importance because KATP channels are endowed with metabolic sensing capacity and may contribute to downregulation of energy requirements when ATP availability is decreased by causing shortening of the action potential and, therefore, the calcium transient and tension development. The present data support the concept that the decrease in blood flow in hibernating myocardial tissue is decreased in proportion to a reduction in energetic demands (5) and by a mechanism that is independent of ATP-dependent potassium channel opening during an increased work state.
ATP-Dependent Potassium Channels and Hibernation
During baseline conditions, an infusion of glibenclamide at a dose that did not alter either workload or regional perfusion tended to decrease the transmural PCr/ATP. During the increased levels of work with dobutamine, the reductions in PCr/ATP in the hibernating and sham myocardium were equivalent at a time that opening of ATP-dependent potassium channels was inhibited with glibenclamide. These data suggest that preservation of energy in chronic hibernation during a supply-demand mismatch is not dependent on ATP-dependent potassium channel opening. However, the reductions in blood flow at baseline were mild, and the lack of effect with glibenclamide could conceivably have been a result of an insufficient stimulus to maintain KATP channels in the open state. In a swine model of short-term hibernation, with a more moderate reduction in regional blood flow, Shulz et al. (17) have shown that glibenclamide at a similar dose does not inhibit the return of creatine phosphate at a time of sustained reductions in blood flow and function. Those observations are consistent with the present findings and demonstrate that energy preservation in short-term and chronic hibernation is not dependent on opening of ATP-dependent channels during ischemia or during increased work. Opening of ATP-dependent potassium channels on the mitochondrial membrane has been shown to be protective in preconditioned myocardium by preserving the adenine nucleotide pool by a mechanism that involves increased mitochondrial matrix volume (2). Within the second window of protection after ischemic preconditioning, ATP-dependent channel opening on the sarcolemma triggers downstream signaling related to mechanisms involved with cardioprotection (14). Within chronic hibernating myocardium, transcriptional events related to expression of inducible nitric oxide synthase and activation of the mitogen-activated protein kinases are evident (9) and could have conceivably led to a modification of the effects of ATP-dependent potassium channels in a manner different from that during acute sustained reductions in blood flow. In the present study, PCr/ATP results during glibenclamide treatment were comparable in the hibernating and sham myocardium at high workloads, demonstrating that conservation of energy in hibernating tissue with reduced blood flow reserve is not dependent on opening of the ATP-dependent potassium channels.
Hibernation and Protection
Hibernating myocardium has been characterized clinically in patients with severe coronary artery disease and reduced regional blood flow at rest with functional improvement following coronary artery revascularization (15, 18). In the present study, a swine model of hibernation was used by instrumentation of the proximal LAD with a fixed device that does not result in abrupt occlusion of the vessel but rather evolves into a state of chronic supply-demand ischemia (5, 8, 11). Over a period of 10–12 wk, progressive reductions in myocardial blood flow are noted along with a pattern of protein expression associated with the contractile apparatus that differs from chronic myocardial stunning (1, 3). Glucose uptake is increased relative to oxygen consumption in the hibernating myocardial regions during fasted conditions yet evidence of anaerobic glycolysis at rest or during increased myocardial oxygen demand has not been observed (4, 9). The normal energetic state at high cardiac work in the present study demonstrates that adaptations that offset oxidant stress in response to chronic supply-demand mismatch do not necessarily decrease the efficiency of energy production, as defined by transmural PCr/ATP. In tissue extracted after dobutamine stress, transmural ATP levels were slightly but significantly lower in the hibernating vs. sham LAD regions, although total high-energy nucleotides and ADP were not dissimilar. Because the tissue was obtained after the protocol, we cannot exclude the possibility that more rapid hydrolysis of the ATP may have occurred in the hibernating LAD regions. Although under the basal conditions, a stable ATP concentration is maintained in hibernating myocardium, in response to catecholamine stimulation, more ATP loss may occur as a result of previously rebalanced myocardial oxygen delivery and demand under the basal cardiac work state that was disturbed by this stimulation. In the present study, we did not measure ATP in the remote regions after the protocol, which would have allowed us to determine whether the process of hydrolysis of high-energy phosphates is more rapid in tissues from ischemic cardiomyopathy areas after increased work states. We also did not measure regional function during the NMR study and therefore cannot be certain about the stability of regional functional measurements during acquisition of the spectra. Although we have observed that regional wall thickening can be recruited after a brief period of dobutamine treatment in this model, we recognize that temporal differences in the functional response to a catecholamine may differ between 5 and 25 min of persistent stimulation.
The mechanism of preserved energy during a condition of chronically reduced blood flow within hibernating myocardium remains unclear. Our study provides additional support to the notion that hibernating myocardium has undergone important adaptations that improve the relationship between myocardial oxygen consumption and expenditure at increased workload. We have recently shown that mitochondrial protection against anoxia-reoxygenation is observed in this swine model of chronic myocardial ischemia by a mechanism that may involve decreased oxidant damage, possibly by increased expression of uncoupling protein-2 (10). It is possible that intrinsic changes in the mitochondria that reduce oxidant damage within hibernating myocardium preserve energy at high work states. A major unsettled question in cardiovascular physiology however is what factors in the cascade of ATP production, transportation, and utilization control the maximum performance of a normal heart or contribute to the dysfunction of a failing heart. The relationship between steady-state myocardial concentrations of ATP, ADP, Pi, creatine, and PCr and the mitochondrial ATP production capacity remains unclear. This is because in vivo ATP synthetic capacity probably substantially exceeds the expenditure of ATP (as estimated by measurements of myocardial oxygen consumption and assuming a stable P/O) observed in the normal in vivo heart during both open-chest and intact conscious animal studies. Future studies should address the mechanistic basis of the adaptations that lead to the development and maintenance of an energetic steady state in hibernating myocardium. This steady state is characterized by the preservation of cellular integrity. It occurs because there are ("protective") limitations of myocardial ATP expenditure rates that result from reductions of the capacity to expend ATP in contractile processes. Unfortunately, the latter characteristics of the hibernating state contribute to the progressive heart failure that occurs in patients with advanced coronary artery disease.
Transmural bioenergetics in hibernating myocardium, as determined by PCr/ATP derived by 31P-NMR spectroscopy, is normal at baseline and remains normal during the increased work associated with high-dose dobutamine exposure, despite reduced perfusion reserve and inhibition of ATP-dependent channel opening with glibenclamide. These data support the notion that an adaptive process within hibernating myocardial tissue allows the myocardium to operate over a lower range of the oxygen supply-demand relationship to protect against supply-demand ischemia by a mechanism other than ATP-dependent potassium channel opening.
This work was supported in part by a Department of Veterans Affairs Merit Review Grant (E. O. McFalls), National Heart, Lung, and Blood Institute Grants HL50470 and HL67828 (J. Zhang), and a Thoracic Surgery Foundation for Research and Education Nina Starr Braunwald Award (R. F. Kelly).
The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
- Copyright © 2007 by the American Physiological Society


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Pearl Harbor, Dec. 7, 1941, and New York City, Sept. 11, 2001 are two days that as Americans are permanently etched into our way of life — when America was struck by its enemies without provocation. Both of these days, although 60 years apart, are joined by the loss of American life into the thousands followed by a world view into the resolve of the human spirit that makes us supremely American.
What is different though is our enemies then wore a uniform, while our current enemy is unseen and operates in the shadows working against our way of life. We, as a nation, are a symbol of freedom to the world and have a duty to inspire others into a democratic society that fits their culture not ours.
But hope is springing up in the Middle East — the Libyan government has fallen; Syria's government looks like it will fall shortly to a more modern free government; Egypt is headed for a more free society and ousted their government. There is civil unrest trying to change Tunisia and several other countries in the Arab world are working to establish free and open governments. Our efforts in the Middle East are working and now more than ever when new governments are at their weakest, we as a nation are emphasizing withdrawal and abandonment of our new allies in their hour of need. Being rough at home and we as a society cannot stomach it anymore, I have been told. Our resolve is being tested and as a nation we are being judged on what does it mean "to wake a sleeping giant" when you strike America on its home soil.
This September 11th, take a few moments between 8:46 and 10:03 a.m. to remember the 3,000 dead and 6,000 injured in the attacks on 911 in New York, Pennsylvania and DC. Ask yourself this question: What should our resolve be as a nation to establish peace in our world, and how far should we go to protect it? Remembering the cause behind WWII and going back to Iraq was a weak resolve by a collective multinational civilian leadership in WWI and Desert Storm, not our armed services. The price of peace is eternal vigilance, dedicated public safety,/armed forces professionals and a firm resolve by us as a Nation to do what's right, not what's popular.
Scott Finnen
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Survivor of the Holocaust
He was around the age of 13 when all of this happened. He had to work in order for both him and his mom would have food. On September 3, 1942 he opened the door to find German, and Ukraine police at his door and was told to pack up and leave his home. When him and his mom reached the train station there were people there being ordered to go left or right. Left meant you were strong enough to work and right meant to go to the train car. At first he was ordered to go to the right but was stopped by a German Officer who ordered him to the left. Could this have been one of those soldiers who didn't think it was all that right to kill these people? Hank also mentioned that the fur that people had were taken and given to the German soldiers on the Russian front. This shows how much the government was in need and how soldiers were suffering from the extreme coldness to a point where fur coats were needed.


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+966 12 676 0000 Ext.2403, 2405, 5557
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RIO DE JANEIRO — Brazil superstar Neymar struck the winning penalty as the host claimed a first ever Olympic football gold medal Saturday before announcing his intention to step down as captain of the national team.
The Barcelona forward slotted home to jubilant scenes at a packed Maracana as a 5-4 shootout win over Germany, after a 1-1 draw, exacted revenge for a humiliating 7-1 World Cup semifinal defeat to the world champion two years ago.
"This is one of the best things that has happened in my life," said Neymar, who sank to his knees in tears after scoring from the spot.
However, he also suddenly stepped down as captain after taking on the role in 2014 following Brazil's disastrous World Cup exit.
"It was an honor to be captain, but from today I am no longer captain," he told SporTV.
Olympic gold was the only major title to have escaped five-time world champions Brazil in their history.
In front of the biggest crowd of Rio's Games, including nine-time Jamaican gold medalist Usain Bolt, Neymar's brilliant free kick handed Brazil a first-half lead. In honor of the retiring sprinting great, Neymar even adopted the "lightning bolt" celebration, whilst chants of "ole, ole, ole, Neymar" rang around Rio's most iconic arena.
However, Germany captain Max Meyer enjoyed a special celebration of his own as he taunted the raucous 78,000 crowd at the Maracana by kissing the number seven on his shirt when he swept home Jeremy Toljan's cross just before the hour mark.
The first eight penalties in the shootout were all successful before Brazil goalkeeper Weverton stopped Nils Petersen's effort to set the stage for Neymar.
And he didn't disappoint as, with the weight of a nation on his shoulders, he rifled the ball into the top corner.
Brazil Olympic coach Rogerio Micale said Neymar's decision to leave the captaincy in the hands of new senior coach Tite demonstrated his newfound "maturity."
"It demonstrates maturity on Neymar's part. He is a leader in the national team, he is dedicated," said Micale.
And departing German coach Horst Hrubesch refused to be downhearted with silver on Germany's first appearance at the Games for 28 years.
"I am smiling all the time because I am proud of what we achieved."
In stark contrast to the empty seats on show across the Games, even for some of Bolt's marquee races, there wasn't a seat to be had at the Maracana — where Germany won the World Cup against Lionel Messi's Argentina two years ago.
However, it was for the 7-1 mauling in Belo Horizonte five days previously that Brazil was seeking revenge.
None of the players that took to the field that day started Saturday.
Neymar missed the darkest day in Brazil's football history due to two broken bones in his back suffered during a bruising quarter-final win over Colombia.
Yet, the good fortune that escaped Brazil on home soil two years ago was certainly with them in the first-half as Germany were desperately unlucky to go in behind at the break.
Julian Brandt's fine curling effort came back off the bar, whilst Sven Bender also hit the woodwork from close range.
In between times, Neymar had opened the scoring via the bar with a sumptuous dipping effort from 25 yards for his third goal of the tournament.
However, Weverton was beaten for the first time in the competition just before the hour mark when Meyer swept home Toljan's low cross.
Thankfully for Micale's men they were far more clinical from the spot as Augusto, Marquinhos, Rafinha and Luan all netted to hand Neymar the chance to live up to his billing as the host's poster boy for the Games. — AFP


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JERUSALEM — Israeli strikes in the Gaza Strip on Friday and early Saturday killed 13 Palestinians, including a woman and her daughter, medical officials said, in continuing exchanges of fire following a missile attack on an Israeli school bus that critically wounded a teenager.
Israeli aircraft and tanks fired at targets in the Palestinian enclave, and militants launched mortar rounds and rockets at Israel, causing no casualties. Seventeen Palestinians, both militants and civilians, have been killed and dozens wounded since Thursday's bus attack, in the worse flare-up of violence since an Israeli offensive in 2009 against the militant Islamic group Hamas, which controls Gaza.
The Israeli army said it had killed "approximately 15 terrorists" and wounded 50 others.
U.N. Secretary General Ban Ki-moon urged an "immediate end" to rocket fire at Israel and "maximum restraint" by Israel, voicing concern at the reports of civilian casualties.
The Izzedine al-Qassam Brigades, the armed wing of the Hamas, said it lost two senior commanders in an airstrike in the southern town of Rafah, two men east of Khan Younis and three more in two separate strikes in the northern Gaza Strip.
An Israeli drone hit a house east of Khan Younis, killing a 45-year-old woman and her 21-year-old daughter, according to a spokesman for Gaza's emergency services. He said a 55-year-old farmer was also killed in a separate attack in the same area.
The Israeli army said that it had responded to mortar and rocket fire from a neighborhood in the Khan Younis area and that two launching squads were targeted and hit. A military spokesman acknowledged that "uninvolved civilians" appeared to be among the casualties but accused Hamas of using them as human shields by operating inside residential areas.
A militant and an 11-year-old boy were killed and 10 other people were injured, most of them children, by Israeli shelling in Shujaiya, east of Gaza City, medical officials and the Islamic Jihad group said.
The army said it had struck from the air at a squad that had fired mortars at Israel and that it was not aware of civilian casualties.
The body of another Palestinian, apparently killed in earlier fighting, was recovered in Khan Younis.
The army said that about 70 mortar rounds and rockets were fired at Israel on Friday and Saturday, including three Grad rockets aimed at the southern coastal city of Ashkelon and two aimed at the southern city of Beersheba that were intercepted by the military's new Iron Dome missile defense system. The squad that fired the Grad rockets at Ashkelon was targeted from the air and killed, the army said.
A top Israeli general called Thursday's antitank missile attack on the school bus, for which Hamas asserted responsibility, a "new threat" by the group.
"Red lines were crossed," said Maj. Gen. Tal Russo, the chief of the military's southern command.
Special correspondent Islam Abdel Kareem in Gaza contributed to this report.


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OpS! My b'day is actually 2moro :P
But I already celebrate it twice! :D :D :D
Saturday was d BIG celebration. Coz it was my + EpoL + iSa b'day celebration 2gether :)
It was super fun! We did it at Epol's houz. D best houz ever 2 hang out n haf party :P
So we haf dis decent BBQ party during d day. N around 10pm, Dj Shah put on his stuff n d houz was changed 2 club ;) Cool huh? A LOT of pppl came. I think it's d BEST b'day celebration ever! Every1 enjoy it so much, n as usual we party really hard! :)
Sunday was my 2nd b'day celebration. Hahahahaaaa..... I knoe u guyz think it's wayyyyy toooo much! It was me + Aleph's b'day celebration 2gether. But d 2nd b'day celebration was Nana's idea. Dat lil gurl is such a sweetheart.... Love u so much gurl! Akib cooked a really nice chicken chop 4 us. N d b'day boy Aleph sing a song, how sweet! :) They forced me 2 sing, but I did not sing :P :P :P I don't posses a good voice, only my gurlz knew how it sounded like coz I sing at home :P
Okies.... 2day is MOnday. I woke up late. I cleaned d whole houz coz he's coming 2moro. Who? Cute face is coming 2moro!!!!!! :D :D :D He's gonna stay here in Dublin 4 a week! Me myself can't believe it! But I'm very much glad he's coming :)
Less than 2 weeks 2 go b4 I'm back safely at my houz in KL. At least I haf cute face 2 spend my time wif :) Elissa is going back dis Sunday, n Bee is going back wif me. Miera gonna stay here in Dublin n work (Good luck gurl!!!).
By d way, I got a monkey wif BIG scary eyes from sum1. I named it MunKy :P
N thanx 2 Intan 4 d cute mug! I'm gonna misz u terribly when I go back dis summer.... Can't wait 4 d baby 2 come out of ur stomach! So dat I can play wif him/her :)
I mite haf no time 2 update my blog after dis. So good luck 2 my RCSI's frenz (Roy, Pok Lah n others) who's gonna haf their final examination next month. Good luck 2 Faizal 4 his coming exam, n Shihab too. I knoe u guyz can do it! :)
N also lotsa luck 2 ALL my seniors n frenz who's gonna haf their ACCA exam in June. All d best!


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Bangalore, Sep 12: Former Karnataka Minister A Lakshmisagar died here today in a private hospital after a prolonged illness. He was 71 and a bachelor.
Lakshmisagar, Advocate and Professor of Law, was popular as a corporator (1972-75) known for his simplicity and amicable nature,attending to people's grievances round the clock.
He represented Chikpet constitutency in the Legislative Assembly for three consecutive terms-1978,1983,1985 and served as a minister in the Ramakrishna Hegde cabinet.
He held various portfolios including Law and Parliamentary Affairs, Housing, Revenue and Public Grievances and Urban Development.
He was imprisoned during emergency. Chief Minister B S Yeddyurappa has condoled the death of Lakshmisagar.


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Bo is super gentle in you pocket type patterned on the barrels, ropes both ends not finished, though it wouldn't take much. Hauled as a pick up horse and…SOLD
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Cactus stands right at 15 hands and is not done growing! He is well put together and well mannered. Bathes, good with his feet, ties, and has a little…SOLD


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New Delhi, Nov 20 (UNI) The Lok Sabha was adjourned for the second time today till 1400 hrs as a determined Opposition stalled proceedings of the House demanding a discussion on Nandigram violence in which many people were killed.
As soon as the House assembled at 1200 hours after the first adjournment, Mr Prabhu Nath Singh JD(U) asked the Chair to allow a discussion on Nandigram for which he had given a notice. A similar point was made by Mr Braja Kishore Tripathi (BJD) demanding suspension of all other business of the House and a discussion on the subject.
On this, Speaker Somnath Chatterjee said insinuations were being made against the Chair without knowledge of the complete facts. He said he had called a meeting of the Opposition leaders in his Chamber yesterday and conveyed to them that an adjournment motion for which they have given the notice cannot be allowed on the issue.
They should give another notice for discussion under some other rule.
Mr Chatterjee said he had received a notice from them and had called a meeting of the leaders of different parties to discuss the matter at 1315 hrs. The Speaker said it was unbecoming that the Opposition should not allow the House to function.
He then began with the business of the House listed for the day which involved laying down of papers listed against various members.
After this, Mr Chatterjee asked Mr Gurudas Dasgupta (CPI) to move his call attention motion on the situation arising out of high cost of health services and the need to evolve laws to regulate private nursing homes.
The BJP-led Opposition then trooped into the well of the House shouting slogans. These included ''Aaj na hoga koi kaam, pehle hoga Nandigram'', and ''Nandigram par charcha karo.'' Sensing the mood of the Opposition, the Speaker adjourned the House till 1400 hours.


text:
Models For Plug Button Wh
Plug Button Wh by Indesit
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King, Helen
|DOI (Digital Object Identifier) Link:
|Google Scholar:
|Look up in Google Scholar
In the sixth and fifth centuries BC, a series of dramatic shifts in science and the arts took place in the Greek world, and history, medicine, philosophy, and science came into being. This paper examines 'the Greek miracle', looking at how new ideas about 'the origin of all things' were rooted in traditional mythic patterns of thought. In particular, it examines how medical writers thought about the origins of the cosmos, and of disease. The multiple creations of the world present in Greek myth, where the origin of all things was seen as a process of diVerentiation out of original similarity, may have predisposed the Greeks to be open to the new theories of early scientific thinkers.
|Item Type:
|Journal Item
|Copyright Holders:
|2002 IoM Communications Ltd
|Academic Unit/School:
|Faculty of Arts and Social Sciences (FASS) > Art History, Classical Studies, English and Creative Writing, Music
Faculty of Arts and Social Sciences (FASS)
|Item ID:
|Depositing User:
|Helen King
|Date Deposited:
|18 Sep 2012 13:24
|Last Modified:
|30 Nov 2016 14:28
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Quantitative Portfolio Manager
- DOE, Competitive Package
- Boston, MA, États-Unis
- CDI, Plein-temps
- CargoMetrics Technologies LLC
- 06 nov. 17 2017-11-06
CargoMetrics Technologies LLC (CMT) is a Boston-based quantitative investment company. CMT's portfolios utilize sophisticated systems and models, including patented maritime trade algorithms; CMT is a global leader in maritime trade analytics. We are seeking candidates with outstanding academic credentials and hands-on portfolio and trading experience to join our team of quants, data scientists and engineers. We approach markets from a computer science and technology perspective. We are not a traditional Wall Street hedge fund. We are looking for an individual to help us enhance our portfolio construction and trading processes.
The ideal candidate would have some combination of the following skills:
- Strong technical skills - here we include computer/development skills as well as statistical, econometric and mathematical knowledge.
- Portfolio construction and risk measurement - with an emphasis on long/short, leveraged and commodities/derivatives.
- Trading experience with long/short and levered positions - focus on commodities and derivatives would be a plus.
- Quantitative modeling and security selection techniques.
The appropriate candidate will join and potentially lead a team responsible for day-to-day portfolio management and research.
If you thrive in a collaborative, cutting edge, entrepreneurial environment and are looking for a unique opportunity to join an emerging manager with a highly motivated technical team - this is the perfect opportunity for you.
CMT provides its employees with an aggressive but highly collaborative workplace where employees can share and learn from each other. We remain competitive with our benefits, both monetary and nonmonetary, and we are proud to support not only our employees' professional lives but also their passions outside of work.
Job Qualifications:
- We prefer a M.S. or PhD from a top tier institution in a quantitative field, such as Mathematics, Quantitative Finance, Operations Research, Economics, Electrical Engineering, Computer Science, Physics, or related field.
- Experience with systematic, quantitative investment management
- Have intermediate to strong programming skills with a preference for Python, R or similar languages.
- Demonstrated understanding of the factors that drive commodities markets (preferred), equity, currency, and/or fixed income securities.
- Experience trading strategies which include commodity futures currencies (spot and forwards) and global equities (cash).
Team Culture/Benefits
- Competitive compensation packages
- Non-hierarchical, "team first" working environment
- Pre-Tax Benefits: flexible spending, commuter benefit
- 100% Company paid health and dental insurance with HRA deductible covered, life and disability insurance
- Breakfast/snacks/fruit/sodas/coffee provided daily
- 401 k eligible
- Weekly team lunches
- Office in downtown Boston
CMT provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics.
If you are interested in applying for the portfolio manager position, please email resume and cover letter to email@example.com
Position based in Boston, MA


text:
Sky Sports set to air more fishing TV programmes
Sky Sports is to screen more UK fishing shows in 2010 than ever before, Angling Times can reveal.
The media giant already broadcasts the Fish O'Mania final, the British Carp Angling Champs, Thinking Tackle and the ever-popular Tight Lines. But it has now committed to air even more fishing content, including an extra Fish O'Mania contest, the UK Champs and the return of The Extreme Carp Show.
It caps another positive week for angling following the announcement of the Match This £100,000 competition, and can only serve to further strengthen the sport's profile.
The hectic new Sky Sports schedule includes:
The Fish O'Mania XVII Final and Fish O'Mania Champion of Champions Final on July 17 and 18, 2010.
Four 30-minute programmes covering each round of the UK Championship.
Three hour-long shows covering both semi-finals and the final of the British Carp Angling Championship.
Six hour-long episodes of the new The Extreme Carp Show.
Most of the programmes will go out between August and October, including The Extreme Carp Show which returns after four years. It will be produced by Rob Hughes and his Rhap Media team.
"Extreme Carp is a fast, punchy, magazine-style show filmed on the bank. One new feature is 'Myth Busters' where I'll be going underwater to prove or disprove some of fishing's greatest myths. For example, does red line become invisible underwater?" he said.
It will also be the first time since the 'Hooked' shows that a series of matches have been covered, with the screening of all four rounds of the UK Champs, where Rob will analyse the tactics and tackle employed by the key anglers.
"Sky Sports is a great channel for fishing and the relationship between the two is looking bright. I'm also hoping to secure a slot to cover the 2010 carp anglers versus match anglers showdown," added Rob.
Sky production chief Andy Melvin said: "Angling is the UK's biggest participation sport and we should reflect this. We've been at the forefront of angling coverage for years and in 2010 there is more than ever, spearheaded by Keith Arthur's Tight Lines. Competitive angling is also important and programmes such as the Extreme Carp Show and Thinking Tackle get down to the nitty gritty of coarse fishing."


text:
Saturday, September 20, 2008
Condensed Cream of Chicken Soup
monosodium glutamate
disodium phosphate
"spice" (and that would be???)
modified corn starch
But it always seemed like something to live with. I have to pay taxes. I have to spoil my cats. And I don't have a substitute for canned, condensed soups.
But do you know how easy it was to discover I was wrong on that last one? As long as it took to type "homemade condensed cream of chicken soup" in Google and hit send. And look-y what the Very First Result is:
And do you know how incredibly simple this was to make? Of course you don't, because you weren't here when I made it. Here, I'll show you:
Step 1: Mix some stock, milk and seasonings in a pot and boil:
Step 2: whisk together some milk and flour:
Step 3: Combine the two, whisk, boil.
Done! And it took me about 10 minutes from start to finish - and I bet about 1 minute of that was because I took 7 pictures. It might not be quite as fast as getting a can out of the pantry and opening it. But it's darn close.
5 comments:
- kittie said...
Oh - good call! I'd never have thought to even look for this!
So, did it work just as well as the tinned stuff?!
- September 23, 2008 at 5:18 AM
- Deborah said...
Kittie, that's called "Fodder For A Follow-Up Post". :)
- September 23, 2008 at 6:39 PM
- who is themanfromearth? said...
It looks awesome. Your so smart! I might have to buy a can every now and then, though, because I have to get my "shake the can, press on the can, shake again, get out the rubber spatula and scrape" fix on, every now and then.
- October 24, 2008 at 9:55 AM
- Hannah said...
If you ever get tired of using a metal whisk, you should try the cherry wood whisk at Jonathan's Spoons (www.woodspoon.com). They are a lot easier to clean than the traditional metal whisk and they fit in a drawer a lot easier. All of his products are handmade in the US from wild cherry wood, and I think that's pretty cool.
- November 9, 2008 at 5:37 PM
- Ruth Daniels said...
What a great post. Thanks, now I'll just bookmark it for those days when nothing but condensed soup will do.
- November 12, 2008 at 5:32 PM


text: Hi guys! New here, thought it seemed like a good place to ask for some troubleshooting advice before I run down to Verizon for some help! I checked through the forums and didn't see anything about this particular problem, so if there is another forum, I apologize! I got my HTC Droid Incredible back in July, and it worked amazingly for the last couple of months. All my apps have been running smoothly until recently, when Facebook started giving me problems. Now I don't know if this is a server thing, facebook itself, or a glitch in my phone, but I keep getting error messages. When I refresh my notifications I get: Cannot retrieve notifications. Please try again later. [601/Parser error: unexpected '-' at position 64.] And occasionally I get another error/null type message when I try to refresh my newsfeed. I've tried to reboot my phone, reinstall facebook, let my phone die recharge it blah blah blah. So, if anyone has any suggestions, please let me know! Thanks :]


text:
end of school/exams party today! i love summer!
Thursday, November 27, 2008
Wednesday, November 26, 2008
words don't work for me anymore.
i've been trying for conversations and i've been trying for prayer and i've been trying to find the words but i think i've lost them somewhere and i've been searching in every place but every place has failed me and words just don't work for me anymore and it hardened my heart and removed my emotions and i've refused to look you in the eye and refused to let you in out of fear that my emotions would be too much to handle but you've been trying to teaching me not to fear and just to trust and to let it out and to let it go but it's taken this long for me to let you teach me and so far all i know is that you've taught me it's okay to cry and i'm not even going to pretend that picking up myself and straightening my clothes and wiping away my tears will make everything be okay because i can't pretend that there's some sort of answer to this sort of question and it's like i'm at a dead end and i only want to go forward but there's a not-so-imaginary wall that i'm about to stumble into and i have no option but to take myself and all my needs and wants and wishes and desires and go back to the start.
Posted by ayla at 3:39 PM 0 thoughts
Monday, November 24, 2008
only by the night.
i want to go to Kings Of Leon so badly..
i had my last exam today and it feels sooo good to be free! no school no exams no nothing for like three months! summer's officially here for me! i'm so happy!
Posted by ayla at 5:56 PM 1 thoughts
Sunday, November 23, 2008
this is hard.
coldplay lyrics would be fitting today wouldn't they?
my head hurts. i've had a crazy headache for the last couple days and i'm just over tired and dizzy. i can't find my diary under the masses of junk in my bedroom as a result of coming home last night and chucking all my bags and everything from my bed on the floor and collapsing in bed. it's annoying, i didn't realize i relied on it so much.
i really like these pictures of Cory.
and this is because i'm bored and extremely talented at procrastinating..
4 things I did today: it's only 11 am but i have
-woken up to Nates birthday invitation.
-make alterations on two dresses i bought from an op shop yesterday.
-received the silliest relationship advice ever heard from my mother.
-experienced mewithoutYou (listening to them is an experience that includes listening, dancing, singing- and i bit of shouting- and a whole lot of inspiration)
-woken up to Nates birthday invitation.
-make alterations on two dresses i bought from an op shop yesterday.
-received the silliest relationship advice ever heard from my mother.
-experienced mewithoutYou (listening to them is an experience that includes listening, dancing, singing- and i bit of shouting- and a whole lot of inspiration)
..that reminded me i need to eat breakfast.
4 things on my to do list today:
-cancel booking for my birthday at Soho and confirm numbers and make booking at Nautilus.
-study for my history exam.
-make skirt from the lace fabric i bought the other day.
-decide on a dress to wear to Amandas wedding.
4 of my guiltiest pleasures:
-wasting my time on the internet instead of studying.
-eating mi goreng noodles. in bulk ..so terribly bad for me.
-the vintage 'come to papa' chair we bought for the flat the other day. it's so comfortable i will race you to it and kill you if you get there first.
-dreaming of how things could be and ignoring the fact that some things just can't happen.
4 random facts about me:
-i have 8 pillows and cushions on my bed and can't sleep properly without them.
4 things on my to do list today:
-cancel booking for my birthday at Soho and confirm numbers and make booking at Nautilus.
-study for my history exam.
-make skirt from the lace fabric i bought the other day.
-decide on a dress to wear to Amandas wedding.
4 of my guiltiest pleasures:
-wasting my time on the internet instead of studying.
-eating mi goreng noodles. in bulk ..so terribly bad for me.
-the vintage 'come to papa' chair we bought for the flat the other day. it's so comfortable i will race you to it and kill you if you get there first.
-dreaming of how things could be and ignoring the fact that some things just can't happen.
4 random facts about me:
-i have 8 pillows and cushions on my bed and can't sleep properly without them.
-i love history. it's my favorite subject after sewing and i would come to school just for history this year when most people wagged that period.
-i love Michael Jackson. i still listen to the record i have from when he was black.
-i love to wear heels. although my boyfriend wishes i wore nike air force ones haha.
-i love Michael Jackson. i still listen to the record i have from when he was black.
-i love to wear heels. although my boyfriend wishes i wore nike air force ones haha.
and this picture makes me happy.
Posted by ayla at 12:50 PM 1 thoughts
Thursday, November 20, 2008
life is so happy.
it always is.
i was telling my mum the plans i have for the next few weeks as we drove home today and she said to me: "ayla, why don't you just stop and slow down, you're doing so much."
why? why would i want to? i don't understand. i'm doing all i want to do and having fun but i'm still enjoying lazy days and the experiencing the beauty that life holds.
i told her: "it's because this is the best time of my life and i want to make the most of it"
"but that's what you said last year"
"yeah. and i'll say it every year from now until they're all gone, because every year is the best year when you make the most of what you have."
i discovered Elisabeth Arkhipoff in Russh when Rebecca was doing my hair for her course today. i really love her art work:
Posted by ayla at 4:52 PM 0 thoughts
Wednesday, November 19, 2008
this is a picture from my friends collection promo. keep an eye out for Liz Proverbs! 2nd year design student but she's got talent.an
and i'm digging Rebecca Taylors new look for this summer at the beach..
SO EXCITED about summer. two exams down, one to go and i am officially free!! plans so far: NOTHING! well that's a bit of a lie..i plan and moving into the flat and going to the beach every day.
Posted by ayla at 10:37 PM 0 thoughts
Wednesday, November 12, 2008
"fashion will beat the recession"
the words of a guest speaker at the fashion show on tuesday night. i wish i had photos from it to share some of the wonderful collections! namely Liz's.
it's been so hot lately and i've been eating strawberries and wearing shorts all week..today's the first day it's clouded over. i love summer and i don't even have to say "i can't wait for summer holidays" anymore, cause i finished school yesterday and i'm freeeeeeee!!! (except exams, but that's a breeze, i've already passed the year)
i wish i could dress in Rachel Comey for summer
Posted by ayla at 5:02 PM 1 thoughts
Monday, November 10, 2008
i don't really have anything to say but i just wanted to post a picture with the most amazing girl in the world.
thanks for everything.
Posted by ayla at 11:14 AM 1 thoughts
Sunday, November 9, 2008
Friday, November 7, 2008
goodnight and go.
after my only full day of school this week, hanging out with J and three of her crazy crazy 10 year old boys and a night of waitressing(a job which i intended to quit last night, but somehow ended up being rostered on to work tonight as well) i showed my face at Gems show, went for coffee and ice cream with the girls before leaving town to hang with Tim. i'm so tired. and so, sew is what i decided to do with my saturday:
(from Oct issue of NYLON)
Skipping beats, Blushing cheeks. I am... struggling.. Daydreaming, Bed scenes in... the corner cafe. And then I'm left in bits recovering tectonic... tremblings. You get me every time. Oh, why'd ya have to be so cute? It's impossible to ignore you, Must you make me laugh so much? It's bad enough we get along so well.. Say goodnight and go. Why's it always always: goodnight and go? Oh, Darling not again, Goodnight and... go...
Posted by ayla at 3:12 PM 0 thoughts
Tuesday, November 4, 2008
i love andy
Posted by ayla at 7:20 PM 2 thoughts
November 5th
today is one month until my birthday, and i have no idea how we got here. i have no idea where this year has gone and ever since i realized that we're in November, and that next month is not just my birthday but it's Christmas and New Years. and the years disappeared and we're starting again in 2009, i've been in a constant state of freak-out (i know that's not a word but i can't think of anything to describe how stumped this has made me). i swear i looked at the calendar in July and all it took was a blink to get to November. now i have 4 days of school left and three exams to go until summer.
maybe i was freaking out because i thought i've wasted this year, but thinking back on it this has been the busiest and best year of my life. me and frances spent class yesterday reflecting on all the good and fun things that have happened to us this year. i will elaborate:
- firstly, starting the year at camp, with worship bang on the changing of the years
- parachute
- summer's DREAM TEAM and trips to the batch and the lake house
- becoming a leader at Primal
- going overseas! (the definite highlight of the whole year) getting to go to England, Wales, France, Australia and Thailand.
- seeing my Grandma for the first time since i was about 10 and my dad for the first time in a year
- preaching for the first time at Primal and taking Underground for the first time
- getting to see Rachel get married (your turn soon Amanda!)
- entering fashion shows and winning and overlocker from it!!
- being involved with Invisible Children, putting on successful events
- going to my first ball!
- going to WOW awards in Wellington (funest school trip of my life!)
- got my first tattoo (it's true that nothing can separate me from the love of God- i have it written on me for life! haha)
- passing Level 2 NCEA before the year has even finished
- and i can say safely that there has been road trips for at least every third weekend for this year. it has been so much fun, and there are still more to come before the year is out.
this year has been the first year when i have been completely solid and sold out for God. the places he has taken me have already been beyond what i would have thought. through ups and downs his love really has sustained me. at the beginning of the year this was the scripture God gave me for 08:
Exodus 34:10-11: The Lord replied, "All right, this is the covenant I am going to make with you. I will perform wonders that have never been done before anywhere in all the earth or in any nation. And all the people around you will see the power of the Lord- the awesome power I will display through you. Your responsibility is to obey all the commands I am giving you today. Then I will surely drive out all those who stand in your way"
this has been fulfilled in some ways, but i don't believe it has been to any extent of which it was first meant. i'm really craving that fire which i had for the first half of the year, i'm really longing to be head over heels again. i just don't know how to do it.
and although i lost the girl who was my best friend this year, i have grown from this and not only restored old friendships but built new ones and now i have to say i am so blessed to know the people i do and the people who i am privileged enough to spend my time and share lives ups and downs with are hands down the most amazing people i have ever met. i couldn't see my self without J in my life- our friendship is so special and the way the puzzle pieces of our lives and characteristic fit together is beyond my understanding.
and although i spent at least 6 months of this year holding on to the idea of a certain boy and trying to make things work(which in no way do i regret, the things i learnt from this are priceless), i finally let go and now i have the most amazing boyfriend, who is my friend and my boy. that's the way i always wanted it to be. this came so unexpectedly and it truly does rest on the advice i've so often given others, that you only find someone when you stop looking. i'm so lucky to have Tim.
and mention should also go to Mike. he has officially been my longest friend and has stuck by me through all the ups and all the downs and supported me in everything even when he has disagreed with my choices, stuck with me in every silly phase i've been through. and without being cheesy, i actually don't know where we'd be without each other.
everything in this year has been amazing. i still don't know where it's gone, and i'm not even going to say i'm looking forward to 09, i'd prefer to stay where we are thanks.
Posted by ayla at 12:34 PM 1 thoughts
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"I don't take it very seriously," he said."I hope you don't either."
Director/writer/actor Jim Jarmusch is rather obvious. Tall, long thin face, strong bone structure, sideburns and spiky white hair that can be best described as Cresta Blanca - the white top at the crest of a mountain.
With more than 25 years of film directing under his belt, Jarmusch has gained a following of indie film buffs who dig his off-kilter movies. His characters aren't necessarily people you'd want to befriend - they're more like silver screen case studies. Cold Duck instead of Champagne.
While Jarmuschian films are often quite amusing, they also have a touch of darkness, an edginess that's helped him establish his own film noir niche. Performers like Johnny Depp, Billy Bob Thornton, Alfred Molina, Gabriel Byrne, Bill Murray and Steve Buscemi don't think twice when Jarmusch calls with a new script.
Coffee and Cigarettes (2003) is the latest Jarmusch film to be released on DVD. Like many of his other films, it's shot in black and white, and features seedy coffee bars and gritty little roadhouses. However, the film is an interesting departure from many of his other movies. This time around, instead of developing more wild and crazy characters, the director simply lets the actors play themselves.
Factoid: Coffee and Cigarettes took 17 years to create! The film's a compilation of 11 separate vignettes. The first, which features a highly caffeinated conversation between Italian comedy actor Roberto Benigni and comedian Steven Wright, was filmed in 1987. Five years later, Jarmusch filmed the second vignette - a tete-a-tete over music, booze and cigarettes between seasoned musicians Tom Waits and Iggy Pop - which earned him the Palme d'Or award for short films at the 1993 Cannes Film Festival. The remaining scenes were completed over the last decade.
What binds this movie together is the energy and wildness of the actors. It's as if Jarmusch fed them potent doses of wine and spirits, thick, sludgy coffee and high-nic cigarettes, and then yelled "Action!" In most cases, the improvisational behavior is hysterical and brilliant.
Each vignette revolves around some odd topic of discussion. In the case of Jack White and Meg White of The White Stripes, it's about messing around with patented Tesla coils (no, not the big hair band). For Bill Murray and Wu Tang Clan members RZA and Genius/GZA, it's about trippin' out on herbal and medical phenomena. And for Cate Blanchett, it's all about the awkwardness of meeting up with her jittery, punk rock sister Shelly (played by herself) in
a sophisticated salon.
While every teaming has its fans, it's hard to deny that the casting of Alfred Molina and Steve Coogan is genius. Essentially, you're presented with two extremely gifted actors discussing which one is Tinseltown's mack daddy. The dialog's similar to that of Tim Robbins and his Hollywood adversaries in the Robert Altman classic The Player - except that Molina and Coogan aren't ruthless. They're just over-caffeinated.
Jarmusch, who attended the U.S. debut of the film at the 2004 San Francisco International Film Festival, explained that he intended the film to be a bit crazy and off-the-hook.
If you're looking for a wine that'll stand up to the spicy dialog in Coffee and Cigarettes, try the Sterling 2002 Vintner's Collection Shiraz ($12), an affordable and widely available fruit-driven wine. If you're watching the film with a group of friends, concentrate on a collage of tempting wines produced by boutique wineries in California's Sierra Foothills. Check out: the succulent and sexy Vino Noceto 2002 Sangiovese (Amador County, $15); the juicy, spicy Karly 2002 Warrior Fires Zinfandel (Amador County, $24); the vivaciously bold Twisted Oak 2002 Tempranillo (Calaveras County, $22); and the Clos Saron 2000 Black Pearl (Sierra Foothills, $35), a delectable, mouth-watering blend of syrah, cabernet sauvignon, petite verdot and sangiovese. Like a good indie flick, these are harder to find but well worth the effort!
(and wines to sip while watching)
Stranger Than Paradise (1983)
Wine: Royal Tokaji 1996 Blue Label, 5 Puttonyos ($40/500 ml.)
Down By Law (1986)
Wine: Villa Banfi Centine 2002 Rosso di Toscana IGT, Italy ($11)
Mystery Train (1989)
Wine: Roshambo 2001 Zinfandel, Dry Creek Valley ($21)
Night On Earth (1991)
Wine: Quinta de Roriz 2001 DOC Reserva ($24)
Dead Man (1995)
Wine: Rosenblum Cellars 2002 Petite Sirah, Rockpile Road Vineyard, Dry Creek Valley ($34)
Ghost Dog: The Way of the Samurai (1999)
Wine: Sokol Blosser Evolution, 8th Edition ($15)
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