text:
Health & Fitness :: There are some allegations as to the reasons of Acneposted on 15 Jun 2014 11:52 by yieldingnurse4633
As engineering science and science assist us find the actual roots, we are capable to dispel a good deal of of the incorrect conceptions surrounding acne. Nonetheless, the myths still persist. Here are a good deal of more normally known myths:
Myth: Acne is caused by poor hygiene.
Absence or unavailability of cleanliness is not the reason for acne. There are skin contagions related with acne due to a mixture of sebum and dead cells that lie underneath the surface of the skin. Absence or unavailability of gentle cleansing of the skin with soap and water once or twice a day will assist in holding skin as healthy as possible, it's ineffective in clearing away the skin contagions. Take care not to scrub too hard as this could farther irritate acne.
Myth: Grease and Chocolate will cause acne.
Individuals have believed for years that eating chocolate will cause pimples. Individuals no scientific evidence for this - studies have shown no direct relationship between consuming chocolate and acne breakouts. This is also true of other foods like potato chips and French fries. Eating overabundant of these types of feed is, however, unhealthy, and advisable to eat in moderation.
Note: Although chocolate and greasy foods do not cause acne, a good deal of foods DO seem to exacerbate it. Milk and foods high in iodine (as found in seafood) seem to irritate acne.
Myth: Sex is directly linked to acne.
Everything from masturbation to celibacy has been blamed for acne. This again is false. Altho there's a link between hormone levels and sexual activity, it's unclear what the link between sex and levels of sebum (causing acne. ) Emotions and stress also impact hormone levels.
Myth: You will grow out of acne.
Acne may last a matter of weeks or as long as assorted years. There is no require to undertake to live with it when there are such a good deal of over-the-counter treatments available to anybody suffering from the discomfort and embarrassment of acne. Dermatologists are also easily accessible for more severe cases.
Myth: Acne only affects teenagers.
Altho 85% of adolescents experience acne, adults are susceptible to suffering from acne when they are in their 30s or 40s.
Myth: Acne is only a superficial condition.
Because of the severity of physical disfigurement acne leads to psychological stress. There are strong links to depression, social withdrawal and low self-esteem.
Myth: Popping/Squeezing pimples will get rid of them faster.
This may actually irritate acne by disseminating the bacteria which is causing it! Squeezing pimples How to Get Rid of Pimples may also lead to permanent scarring.
Myth: Sun exposure will assist clear up acne.
Altho short-term effects of the sun seem to arid out excess oils, the skin speedily adapts to sun exposure. This eliminates long-term gains from sun exposure and increments the potential for skin damage and cancer.
Myth: Wearing makeup causes acne.
Healthful skin is the most proficient way to keep out of the way of acne. Because a good deal of makeups may clog pores, acne may in fact result. Cosmetics have flooded the market with labels indicating they are noncomedogenic or nonacnegenic, which means they'll not cause acne. These brands of makeup are safe to employ. Healthful actually include ingredients that assist treat acne.
Myth: Using more acne medication will treat the condition faster.
Excess use of ointments may actually irritate the skin, worsening the condition. Oral medications may be dangerous to your overall health. Always use medications as directed.


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Samsung Galaxy Mega 2 Listed On Official Online Store at Rs. 20,900
Samsung has listed Galaxy Mega 2 on its official online store in India. Samsung Galaxy Mega 2 features a 6.0-inch HD TFT display, a 1.2GHz quad-core Qualcomm Snapdragon 410 processor and running on Android 4.4 KitKat. It comes with a 1.5 GB RAM, 16 GB internal storage and sports 8 MP rear facing camera along

subset: commoncrawl


text: Mark Rafn said: > On Thu, 13 Mar 2003, Steve Langasek wrote: >> So the requirement here is that if the RPC service is part >> of the source code, you MUST ship the server, or not ship anything at >> all. > > Huh? I'm missing that paragraph in my copy of GPLv2. You can't ship > the server and the client without providing source to the server, but > you can ship the client by itself, even if it's not so useful without > the server. The paragraph above is the result of the logic: 1. linking -> combined work 2. dynamic linking -> linking 3. dynamic linking over network (RPC) -> dynamic linking 4. network service -> dynamic linking over network "Therefore", network service -> combined work. The GPL FAQ appears to both contradict and support point 4: http://www.fsf.org/licenses/gpl-faq.html#MereAggregation, since the network service would probably be implemented over sockets, but is "exchanging complex internal data structures" > The paragraph after section 2c seems to say that if the client can > reasonably be considered a seperate work (and almost any client can be > IMO), the GPL only affects both sections (client and server) if they are > distributed as part of a whole. > > Similarly, I believe it's allowed to distribute a GPL program that can > use a GPL-incompatible library at runtime, and to use that program. You > just can't distribute the GPL program and the library together. Your belief appears to differ from the FSF's interpretation of the GPL, according to http://www.fsf.org/licenses/gpl-faq.html#LinkingWithGPL --Joe


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Business Walks
As part of it's economic development mandate, the Burnaby Board of Trade periodically conducts Business Walks to visit different business districts throughout the city. A Business Walk is an economic development activity which involves visiting businesses of all sizes and sectors in person, door-to-door, to get input on how their business is performing, get their impression of the business climate in the city, and identify both areas of strength and potential issues or obstacles.
The input gathered from these business interviews is used to create a Business Sentiment Report of the area. The below document details the results of the BBOT's Business Walk in Burnaby's Lake City-Production Way district, conducted on July 27th, 2016.
Lake City-Production Way Business Sentiment Report:
To view the results of our previous Business Walks, click on the links below:


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Meeting dated 15 Dec 2008 at State Secretary Building Shah Alam
The meeting was chaired by YB Saari and was attended by the Developer, Architect, Syabas, SPAN, PHUKB Comm (Dr Rafick/Mohd Ali), a state approved PMC and others
In the meeting, the state has informed the developer that it intended to intervene the project for the sake of house buyers. All parties was offered to give their briefing. The outcome of the meeting is as follows:
1. The developer is to provide by next monday to the Housing Board by the 22nd Dec a revise project schedule and cash flow projections.
2. By the next meeting, the state will make its decision on the mechanism it wants to ensure the project continuity.
3. The committee will be kept inform of the progress.
4. The state appointed PMC will meet the Bond holders.
The committee will continue to the update the house purchaser accordingly.
Dr Rafick


text:
RE: [sig] Re: Digest Number 3493
Expand Messages
- That would be great! So......any way I could shamelessly beg for a translation of my apprentice contract? 4 sentences......I believe in brevity!
From my Android phone on T-Mobile. The first nationwide 4G network.
-------- Original message --------
Subject: [sig] Re: Digest Number 3493
From: Tatiana Golter <littlegreensardine@...>
To: firstname.lastname@example.com
The SCA College of Heralds forgets that in some languages there are such
things as conjugations. So when the word is taken out of context, it looses
I had similar issue with registering my surname, they told me that the form
was wrong. So I wrote an appeal. The name passed.
I understand that languages change with time, however, some words and
conjugations have not changed. I grew up with this stuff, which should
account for something, I would think.
So, if you want to register Dom of some such Thing, I suggest that you do
it. I could help you with forming the name, as much as I can. I have a
decent collection of books that might help. At the very least it will be a
good try. And hopefully, SCA will have one less badly formed Russian name.
You can contact me directly, or through the list. I am also on Facebook and
Sig Facebook group.
Tatiana Moskovskaia
[Non-text portions of this message have been removed]
[Non-text portions of this message have been removed]
Your message has been successfully submitted and would be delivered to recipients shortly.


text:
The path to health is not paved in gold, it's paved in green. Yup, green is your BEST FRIEND. Green is the colour of money, green is the colour of health and it's also the colour of chlorophyll.
Chlorophyll is basically liquid sunshine. It is the substance in plants that allows them to absorb light from the sun and convert it into usable energy. So when you think about it, when we eat raw green foods such as green leafys, cucumber, lettuce, kale, alfalfa sprouts, broccoli, green beans, swiss chard and drink grasses like wheatgrass we are filling our body with the equivalent of the plants blood. The blood that has coursed through its leafy veins to enable it to grow as big and as beautifully green as it is.
Chemically, the blood of the plant, chlorophyll is very similar to our blood, and when consumed, it easily slots right in with our own blood helping to oxygenate us and breathe life into every cell.
You can grow wheatgrass at home fairly easily, (which I have done) but with my already jam-packed schedule of juicing, smoothying, yogaing, meditating, visualising, raw cooking, writing 3 books, blogging for this website and coaching my clients, I decided that I could do with one less thing to do! So i bought some frozen wheatgrass.
It suits me down to the ground as it's quick and easy and I can just chuck a frozen wheatgrass shot into a juice or smoothie and hey presto, I've just supercharged it and myself in double-quick time! There is no excuse for the "I haven't got time to grow or juice wheatgrass or anything else for that matter – I can just about manage a glass of orange juice out of the fridge in the morning" people.
Wheatgrass is extremely cleansing, can help improve circulation, build a stronger immune-system, combat free radicals and increase energy. It is also a fantastic source of vitamins A, C, E, most B vitamins and contains laetrile which is shown to have anti-tumour properties.
So what are you waiting for? Even if you had two 15ml "shots" of wheatgrass a week you would be doing your body a whole lotta good!
I get my wheatgrass (and seeds) from Aconbury.


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12 Actors Playing Against Type
Emma Watson, 'The Bling Ring'
Emma Watson captured our hearts as the clever and caring Hermione Granger in the Harry Potter movies. Needless to say, we were quite impressed by the British actress' ability to play a narcissistic California party girl-turned criminal in The Bling Ring. Watson's trashy Valley Girl accent was spot-on.
Jim Carrey, 'Eternal Sunshine of the Spotless Mind'
Focus Features
Jim Carrey is best known for his wacky comedy roles, but his brilliant turn as the emotionally withdrawn Joel Barish in Eternal Sunshine of the Spotless Mind showcased the actor's dramatic side.
Adam Sandler, 'Punch-Drunk Love'
Columbia Pictures
Adam Sandler become a star by appearing in a slew of successful broad comedies, but he ventured into unknown territory when he played the emotionally complex Barry Egan in Punch-Drunk Love. Bringing a sense of realism to the deeply depressed character, Sandler received rave reviews for his performance.
article continues below ad
Jonah Hill, 'Moneyball'
Columbia Pictures
Jonah Hill made a name for himself playing rotund, wisecracking sidekicks in Judd Apatow comedies. His dramatic role as a Yale brainiac in Moneyball not only surprised audiences, but also earned Hill his first Oscar nomination. Still, we can't help but think his success has gone to his head — Hill came off as a real douchebag in that notorious Rolling Stone interview.
Robin Williams, 'One Hour Photo'
Fox Searchlight
Famous funny-man Robin Williams showed us that he is a truly versatile actor in his turn as a lonely, obsessive photo technician in the psychological thriller One Hour Photo.
Tom Cruise, 'Tropic Thunder'
Paramount Pictures
While Tom Cruise has dabbled in a lot of genres, he generally takes on the role of the handsome, likable everyguy. In Tropic Thunder, however, he made a complete 180 by playing the sleazy, foul-mouthed, pot-bellied movie producer Les Grossman. And he was scarily convincing.
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Vanessa Hudgens, 'Spring Breakers'
Seven years after skyrocketing to fame in the Disney hit High School Musical, Vanessa Hudgens shattered her good girl image by snorting cocaine, having a threesome, and committing armed robbery in Spring Breakers.
Will Ferrell, 'Stranger Than Fiction'
Columbia Pictures
When we think of Will Ferrell, we picture clueless comedic characters (say that three times fast) whose professions typically involve some kind of sport. This is not the case with Harold Crick, the mundane IRS auditor that the SNL vet portrayed in Stranger Than Fiction. His uncharacteristically restrained performance earned Ferrell a Golden Globe nomination.
Tom Hanks, The 'LadyKillers'
Buena Vista Pictures
From Sleepless in Seattle to Forrest Gump, Tom Hanks rose to fame playing lovable good guys. So it was pretty shocking to see him as the creepy facial hair-sporting crime boss G.H. Dorr in The LadyKillers.
article continues below ad
Leonardo DiCaprio, 'Django Unchained'
Warner Bros. Pictures
Leo certainly has a knack for playing conflicted but generally "nice-guy" type characters, so his performance as the sadistic slaveowner Calvin Candie in Django Unchained marked a serious departure for the actor. The role earned Leo yet another Golden Globe nomination but brought him no closer to that elusive Oscar.
Rodney Dangerfield, 'Natural Born Killers'
Warner Bros. Pictures
Rodney Dangerfield made audiences crack up with his comedic film roles and his signature "I don't get no respect" standup routine, but in 1994, the comedian made a rare dramatic appearance as a physically and sexually abusive father in Natural Born Killers.
Jennifer Aniston, 'Horrible Bosses'
Warner Bros. Pictures
Jennifer Aniston has made a name for herself portraying the cookie-cutter female lead in a variety of romantic comedies. But as one of the titular characters in Horrible Bosses, she surprised audiences by playing an raunchy dentist who sexually harasses her male assistant.


text:
SQL Server is, by default, case insensitive; however, it is possible to create a case-sensitive SQL Server database and even to make specific table columns case sensitive. The way to determine if a database or database object is to check its "COLLATION" property and look for "CI" or "CS" in the result.
CI = Case Insensitive
CS = Case Sensitive
A common result is:
CI indicates that the server is case insensitive.
Again, this will output something like:
SELECT collation_name
FROM sys.databases
WHERE name = 'your_database_name'
WHERE clause and include
name in the
SELECT list:
SELECT name, collation_name
FROM sys.databases
WHERE TABLE_NAME = 'your_table_name' AND CHARACTER_SET_NAME IS NOT NULL
Another command for checking the case-sensitivity and other properties of the database server is:
EXECUTE sp_helpsort
This will return something like:
Latin1-General, case-insensitive, accent-sensitive, kanatype-insensitive, width-insensitive for Unicode Data, SQL Server Sort Order 52 on Code Page 1252 for non-Unicode Data
Finally, to see all collations supported by your SQL Server installation, run this:
SELECT name, description FROM sys.fn_helpcollations()
The result will be something like this:
Nat Dunn founded Webucator in 2003 to combine his passion for web development with his business expertise and to help companies benefit from both.


text:
Join Jo Malone London to celebrate the launch of Blue Skies & Blossoms, a playful and carefree collection of scents.
Celebrate blossoms, the messenger of spring and enjoy champagne*, treats and a signature Hand & Arm Massage.
Thursday 9 April
5.00pm – 6.00pm or 6.30pm – 7.30pm
Please call 0191 232 5100 or visit the Jo Malone London boutique
for further information or to book your place.
*Customers must be 18 or over.


text:
Redesigned Landscape Architecture NZ magazine out now
15 May 2016
The latest issue of Landscape Architecture NZ is out now.
This redesigned issue features projects by Reset Urban, Blakely Wallace Associates and Isthmus Group, as well as the ever-popular planting guide, and a range of perspective pieces from industry professionals.
LA also has a new website laonline.co.nz a place for news and additional information relating to landscape architecture and urban design professions.
Official magazine of the New Zealand Institute of Landscape Architects.Learn more


text:
Has Pat ever gone "on the record" about x86 64-bit support?
Has Patrick ever explicitly expressed his opinion about an "official" version of 64-bit Slackware?
Not sure if he has but there is a x86_64 slackware version. http://www.slamd64.com/ is the only one I know of that is close.
It is almost certainly a combination of all of those.
Even if somebody donated the 64 bit machine to him, he doesn't have the time to maintain x86 and x86_64 versions.
If anything, he would likely name Slamd64 as an official port, and work with them to maintain the quality he strives for in the mainline distribution.
|All times are GMT -5. The time now is 01:38 AM.


text:
You are here
The epidemic of oesophageal carcinoma: Where are we now?
Cancer Epidemiology
- Between 1973 and 2001, oesophageal adenocarcinoma was one of the fastest rising cancers in many developed countries.
- Although the rate of increase has slowed, incidence of oesophageal adenocarcinoma continues to rise and will constitute an increasingly large health burden in the years ahead.
- Men are seven times more likely than women to develop oesophageal adenocarcinoma; the reasons for the striking sex disparity remain unknown.
- Gastro-oesophageal reflux disease, obesity and cigarette smoking are the main risk factors for oesophageal adenocarcinoma.
- In contrast, the incidence of oesophageal squamous-cell carcinoma continues to decline in Western populations.
- 5-year survival rates for oesophageal cancer remain less than 20%.
Since the early 1970s, the incidence of oesophageal adenocarcinoma has increased dramatically in most Western populations. In contrast, the incidence of oesophageal squamous-cell carcinoma has decreased in these same populations. Epidemiological studies conducted over the past decade have provided great insights into the etiology of oesophageal cancer. These studies have identified gastro-oesophageal reflux disease, obesity and cigarette smoking as risk factors for oesophageal adenocarcinoma, while use of nonsteroidal anti-inflammatory drugs and infection with Helicobacter pylori are associated with reduced risk of oesophageal adenocarcinoma. For oesophageal squamous-cell carcinoma, alcohol and cigarette smoking are the two major risk factors underlying most cases. This review combines a synthesis of these studies with an analysis of data from the United States National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program to discuss the change in incidence of oesophageal cancer and summarize current knowledge of risk factors.
Keywords: Epidemiology, Oesophageal cancer, Barrett's oesophagus, Obesity, Gastro-oesophageal reflux disease.
1. Introduction
Esophageal cancer is a relatively common and highly fatal malignancy. Worldwide, oesophageal cancer is the eighth most common cancer (456,000 new cases in 2012; 3% of all cancers in 2012) and the sixth most common cause of cancer-related death (400,000 deaths in 2012) [1]. The highest incidence rates of oesophageal cancer are seen along two geographic belts, one from north central China through the central Asian republics to northern Iran, and one from eastern to southern Africa (Fig. 1).
There are two main histological subtypes of oesophageal cancer: oesophageal adenocarcinoma and oesophageal squamous-cell carcinoma. Worldwide, oesophageal squamous-cell carcinoma is the most common oesophageal cancer subtype (representing 87% of all cases of oesophageal cancer in 2012 [2]). While this is due largely to high rates in many developing countries, incidence rates of oesophageal squamous-cell carcinoma are significantly higher than rates of oesophageal adenocarcinoma in 90% of all countries presented in GLOBOCAN [2].
There has been a dramatic shift in the epidemiology of oesophageal cancer in Western populations such that oesophageal adenocarcinoma has become the predominant subtype of oesophageal cancer in North America, Australia and Europe [3], [4], and [5]. Epidemiological studies have implicated gastro-oesophageal reflux disease, obesity and cigarette smoking as the main risk factors for oesophageal adenocarcinoma. Together, these three risk factors account for over 70% of all cases of oesophageal adenocarcinoma in Western populations [6] and [7].
Barrett's oesophagus, a condition in which the normal squamous mucosa of the oesophagus is replaced by columnar intestinal epithelium, is the only precursor lesion for oesophageal adenocarcinoma. Barrett's oesophagus is present in up to 15% of individuals with frequent symptoms of gastro-oesophageal reflux disease, and in 1–2% of the general adult population [8]. Compared to the general population, patients with Barrett's oesophagus have at least 10-fold higher risk for oesophageal adenocarcinoma [9]. Consequently, patients with Barrett's oesophagus are entered into a program of periodic endoscopic surveillance. However, although endoscopic surveillance every 3 years is recommended for patients with known nondysplastic Barrett's oesophagus, the absolute risk of oesophageal adenocarcinoma in Barrett's oesophagus is relatively low (0.33% per year) [10] and it remains unclear whether these patients benefit from long-term surveillance in terms of a reduction in overall mortality or risk of death from oesophageal adenocarcinoma [11], [12], [13], [14], [15], [16], and [17].
During the period when rates of oesophageal adenocarcinoma were increasing dramatically in many Western populations, rates of oesophageal squamous-cell carcinoma declined in these same populations; however, oesophageal squamous-cell carcinoma remains the predominant oesophageal cancer subtype in Asia, Africa and South America. Heavy alcohol consumption and cigarette smoking are the main risk factors for oesophageal squamous-cell carcinoma, accounting for 80% and 40% of oesophageal squamous-cell carcinomas in men and women, respectively [18]. Oesophageal squamous dysplasia is the precursor lesion for oesophageal squamous-cell carcinoma [19]. Although treatment effectiveness has improved during the past decade, survival rates for oesophageal cancer remain poor. This review will focus mainly on the descriptive epidemiology and risk factors for oesophageal adenocarcinoma.
2. Recent trends in the incidence of oesophageal adenocarcinoma in Western populations
A seminal paper published in 2005 reported that oesophageal adenocarcinoma was one of the fastest rising cancers in the United States between 1975 and 2001 [3]. In subsequent analyses using data from the United States National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program to quantify rates of change in the incidence of oesophageal cancer over time, it was shown that the incidence of oesophageal adenocarcinoma in the United States increased at a rate of 8% per year until the late 1990s, and at a rate of almost 2% per year since the turn of the century until 2008 [4].
For the purpose of this review, data were analyzed from the SEER 9 registries (covering approximately 10% of the United States' population) where 16,597 cases of invasive oesophageal adenocarcinoma (International Classification of Diseases for Oncology, Third Edition (ICD-O-3) site codes, C15.0-C15.9; histologic codes, M8140-8573) were diagnosed between 1973 and 2012. The overall incidence rate for oesophageal adenocarcinoma during this time period was 1.8 per 100,000 person-years. As expected, the majority of cases of oesophageal adenocarcinoma occurred in men (n = 14,158, 85%) and in whites (n = 15,832, 95%). Almost 8% of all cases of oesophageal adenocarcinoma were diagnosed in persons aged <50 years. Overall, the incidence of oesophageal adenocarcinoma increased from 0.4 per 100,000 in 1973 to 2.8 per 100,000 in 2012 (rate ratio [RR], 7.67; 95% confidence interval [CI], 5.76–10.4) (Fig. 2). In white men, the incidence of oesophageal adenocarcinoma increased from 0.8 per 100,000 in 1973 to 6.3 per 100,000 in 2012 (RR, 7.65; 95% CI, 5.63–10.6). Importantly, rates of oesophageal adenocarcinoma were stable in all sex and racial/ethnicity subgroups in the most recent years. In contrast, the incidence of oesophageal squamous-cell carcinoma (histologic codes, M8050-8082) continues to decline in the United States. Between 1973 and 2012, the incidence of oesophageal squamous-cell carcinoma decreased from 2.8 per 100,000 to 1.2 per 100,000 (RR, 0.44; 95% CI, 0.38–0.51) (Fig. 2).
3. Prognosis for oesophageal adenocarcinoma
In the United States, the overall 5-year survival rate for patients diagnosed with oesophageal adenocarcinoma is less than 20% [20]. For the purpose of this review, data were analyzed from the SEER 18 registries (covering approximately 28% of the United States' population) to examine trends in relative survival rates for patients diagnosed with oesophageal cancer in the United States between 1973 and 2007 [21]. Since the early 1970s, there has been progressive improvement in overall 5-year survival rates for oesophageal adenocarcinoma, from around 5% to almost 20% in most recent years (Fig. 3). Although the proportion of patients diagnosed with early-stage oesophageal adenocarcinoma has increased (patients diagnosed and staged between 2003 and 2007, 25% had localized disease at diagnosis), over 40% of patients are still diagnosed with distant disease. Among these patients, the 5-year survival rate is less than 3%. In the SEER 18 dataset, the 5-year survival rate for oesophageal adenocarcinoma in blacks remains lower than the 5-year survival rate for whites (Fig. 3). Except for advanced stage oesophageal adenocarcinomas, where 5-year survival rates are similar for whites and blacks (both 3%), blacks diagnosed with localized or regional oesophageal adenocarcinomas have worse 5-year survival rates than whites for the same stage (34% vs. 43% and 14% vs. 21%, respectively). The overall 5-year survival rates for oesophageal squamous-cell carcinoma in the United States are slightly lower than the rate for patients with oesophageal adenocarcinoma (patients diagnosed between 2003 and 2007, 15% for oesophageal squamous-cell carcinoma vs. 19% for oesophageal adenocarcinoma).
4. Selected risk factors for oesophageal adenocarcinoma
4.1. Demographics
The incidence of oesophageal adenocarcinoma increases with age and is rare among persons aged <50 years [22]. In the SEER 9 registries, for oesophageal adenocarcinoma diagnosed between 1973 and 2012, incidence rates were 21 times (RR, 20.8; 95% CI, 19.6–22.1) and 44 times (RR, 44.4; 95% CI, 41.8–47.1) higher among persons aged 50-69 years and ≥70 years, respectively, as that it was among persons aged <50 years (Table 1; Fig. 4). One of the most intriguing observations in oesophageal adenocarcinoma is the striking sex disparity; in all populations, incidence rates of oesophageal adenocarcinoma are significantly higher among men than women [22] and [23]. In our analysis of SEER 9 data, the incidence of oesophageal adenocarcinoma was 7-fold higher (RR, 7.49; 95% CI, 7.17–7.82) among men compared with women (Table 1). Interestingly, the male-to-female ratio for oesophageal adenocarcinoma has not changed over time [24]. Overall, the incidence of oesophageal adenocarcinoma was four times as high among whites as it was among blacks (RR, 4.26; 95% CI, 3.83–4.75) (Table 1). As with the sex ratio, the white-to-black ratio for oesophageal adenocarcinoma has not changed over time [24]. This has important implications for understanding the reasons for the continued rise in the incidence of oesophageal adenocarcinoma and how sex and race may influence risk of developing oesophageal adenocarcinoma.
|All histologies
|Oesophageal adenocarcinoma
|Oesophageal squamous-cell carcinoma
|Age, years
|24.3 (23.4–25.3)
|20.8 (19.6–22.1)
|27.9 (26.3–29.5)
|50.4 (48.4–52.4)
|44.4 (41.8–47.1)
|50.9 (48.0–54.0)
|3.65 (3.57–3.73)
|7.49 (7.17–7.82)
|2.49 (2.42–2.57)
|0.52 (0.51–0.54)
|4.26 (3.83–4.75)
|0.25 (0.24–0.26)
CI, confidence interval; RR, rate ratio. Rates are per 100,000, age-adjusted using United States 2000 standard population.
4.2. Gastro-oesophageal reflux disease
Epidemiological studies strongly implicate gastro-oesophageal reflux disease as the primary causal factor for oesophageal adenocarcinoma. A seminal nationwide, population-based case-control study conducted in Sweden reported that the odds of oesophageal adenocarcinoma developing increase by a factor of eight for persons with recurrent symptoms of gastro-oesophageal reflux disease (i.e., weekly heartburn and/or regurgitation symptoms), as compared with individuals with less frequent symptoms of gastro-oesophageal reflux disease (at least weekly symptoms vs. <weekly symptoms, odds ratio [OR], 7.7; 95% CI, 5.3–11.4) [17]. It was also shown in this study that the risk of oesophageal adenocarcinoma was especially high for persons with more severe and longer-lasting (more than 20 years) symptoms (OR, 43.5; 95% CI, 18.3–103.5) [25]. More recently, in a pooled analysis of individual participant data from five studies (including the Swedish study [25]) participating in the international Barrett's and Esophageal Adenocarcinoma Consortium (BEACON; involving 1128 patients with oesophageal adenocarcinoma and 4057 population-based controls), persons with recurrent symptoms of gastro-oesophageal reflux disease had 5-fold increased risk for oesophageal adenocarcinoma (OR, 4.81; 95% CI, 3.39–6.82) [18]. Compared to persons without gastro-oesophageal reflux disease symptoms, persons with daily symptoms of gastro-oesophageal reflux disease had 8-fold higher risk of oesophageal adenocarcinoma and those with symptoms longer than 30 years had 6-fold increase in risk (OR, 6.08; 95% CI, 3.26–11.34) [26]. For Barrett's oesophagus, a known downstream consequence of gastro-oesophageal reflux disease, earlier age at onset of recurrent gastro-oesophageal reflux disease symptoms is associated with especially high risk (age <30 years, OR, 15.1; 95% CI, 7.91–28.8) [27]. Unlike oesophageal adenocarcinoma, population-based studies have not shown an association between symptoms of gastro-oesophageal reflux disease and oesophageal squamous-cell carcinoma [25].
Although studies are still needed to further understand the mechanism that link frequent, severe gastro-oesophageal reflux disease to esophageal adenocarcinoma, the prevailing hypothesis is that chronic reflux of acid or bile injures the oesophageal epithelium, inducing a cascade of cytokine responses that result in inflammation and cell proliferation, thereby initiating the metaplasia–dysplasia–carcinoma sequence [28].
4.3. Cigarette smoking
Cigarette smoking has been consistently shown to be associated with increased risks of oesophageal adenocarcinoma and oesophageal squamous-cell carcinoma. In a pooled analysis of 12 studies participating in BEACON (involving 1540 patients with oesophageal adenocarcinoma and 9453 population-based controls), Cook and his colleagues reported that the risk of oesophageal adenocarcinoma was twice as high among persons with a history of cigarette smoking as it was among persons who have never smoked (OR, 1.96; 95% CI, 1.64–2.34) [20]. While earlier studies had reported inconsistent results regarding a possible dose-response relationship, Cook and colleagues observed a strong dose-response association between pack-years of cigarette smoking and oesophageal adenocarcinoma (≥45 pack-years, OR, 2.71; 95% CI, 2.16–3.40; Ptrend <0.001)[29]. For oesophageal squamous-cell carcinoma, risk among smokers is three to five times that among persons who have never smoked [30]. There is strong evidence of a synergistic effect of cigarette smoking and alcohol use on risk of oesophageal squamous-cell carcinoma [31] and [32].
4.4. Obesity
It is estimated that almost 4% of all cancers are attributable to overweight and obesity [2]. Evidence accumulated from epidemiological studies conducted over the past decade suggests that obesity, abdominal obesity and its associated metabolic abnormalities are associated with oesophageal adenocarcinoma [33]. Because the temporal trends in the incidence of oesophageal adenocarcinoma parallel the increasing prevalence of obesity in the United States population, some have suggested that obesity is the main driver of increased rates of oesophageal adenocarcinoma; however, the extent to which obesity has contributed to the rise in incidence of oesophageal adenocarcinoma continues to be debated [34], [35], and [36]. Furthermore, there are important sex differences in fat distribution such that these differences may in part explain the sex disparity observed in oesophageal adenocarcinoma, with males more likely than females to develop abdominal obesity and its metabolic and systemic sequelae [37] and [38].
In a pooled analysis of data from ten case-control studies and two cohort studies (involving 1,997 patients with esophageal adenocarcinoma and 11,159 population-based controls) participating in BEACON, Hoyo and her colleagues reported that the risk of oesophageal adenocarcinoma was twice as high among persons with a BMI of 30–34.9 kg/m2 as it is among persons with a normal BMI (OR, 2.39; 95% CI, 1.86–3.06) [39]. The odds that oesophageal adenocarcinoma will develop increase by a factor of five for persons with a BMI ≥ 40 kg/m2 (OR, 4.76; 95% CI, 2.96–7.66) [39]. The association between BMI and risk of oesophageal adenocarcinoma has been subsequently reported in large national European prospective cohort studies, including the European Prospective Investigation into Cancer and Nutrition study (n = 391,456 participants, of whom 124 developed oesophageal adenocarcinoma during follow-up) [40] and the Metabolic Syndrome and Cancer project (n = 578,700 participants, of whom 114 developed oesophageal adenocarcinoma during follow-up) [41]. Obesity (as measured by BMI) does not appear to explain however the sex disparity for oesophageal adenocarcinoma: the prevalence of obesity is similar for men and women [42], and the pooled analyses found that the magnitude of the association with BMI was similar for men (30–34.9 kg/m2, OR = 2.47, 95% CI 1.94–3.13) and women (30–34.9 kg/m2, OR = 2.66, 95% CI 1.59–4.46) [39].
Because obesity is strongly associated with gastro-oesophageal reflux disease [43], epidemiological studies examining the association of obesity with oesophageal adenocarcinoma have carefully examined for potential confounding by gastro-oesophageal reflux disease symptoms in their analyses. Regardless of these efforts, imperfect measurement of reflux events in epidemiological studies may have resulted in residual confounding. We recently used a novel study design that employed Mendelian randomization as an instrumental variables approach to causal inference and data from studies participating in BEACON to quantify the non-reflux effects ('independent effects') of obesity on risk of oesophageal adenocarcinoma. The results from this study provide the best evidence yet that the association between obesity and oesophageal adenocarcinoma is independent of gastro-oesophageal reflux disease symptoms [44]. Furthermore, childhood and adolescent BMI may be more strongly associated with oesophageal adenocarcinoma than BMI in later life [45] and [46]. The association is stronger for abdominal obesity (e.g., as measured by waist circumference) than overall obesity, which may in part explain why oesophageal adenocarcinoma occurs more frequently in men than in women.
In contrast, studies have consistently reported an inverse association between obesity and oesophageal squamous-cell carcinoma [47]. While many have argued that this may be due to confounding by cigarette smoking, the inverse association has been found in smokers and non-smokers [48].
4.5. Alcohol
Alcohol is strongly associated with oesophageal squamous-cell carcinoma. The risk of oesophageal squamous-cell carcinoma is three to five times as high among people who consume alcohol as it is among people who have never consumed alcohol [31]. Among smokers, the risk of oesophageal squamous-cell carcinoma is over 20 times as high among heavy drinkers as it is among never drinkers (OR, 21.9; 95% CI, 3.9–122) [31]. Unlike oesophageal squamous-cell carcinoma, epidemiological studies have not shown an association between alcohol consumption and oesophageal adenocarcinoma. In their pooled analysis of 11 studies participating in BEACON (1821 patients with oesophageal adenocarcinoma and 10,854 population-based controls), Freedman and his colleagues found no increased risk of oesophageal adenocarcinoma among persons who consumed alcohol, irrespective of duration and frequency [49]. Interestingly, they observed an inverse relationship with low-alcohol-use and moderate-alcohol-use groups.
4.6. Nonsteroidal anti-inflammatory drugs
There is consistent evidence from observational studies that frequent users of nonsteroidal anti-inflammatory drugs have lower risk of oesophageal adenocarcinoma than non-users of these medications. In their pooled analysis of individual participant data from five case-control studies and one cohort study participating in BEACON (involving 1226 patients with oesophageal adenocarcinoma and 5314 population-based controls), Liao and her colleagues found that any use of nonsteroidal anti-inflammatory drugs was associated with 30% lower risk of oesophageal adenocarcinoma (OR, 0.68; 95% CI, 0.56–0.83) [50]. The inverse association was strongest for current users (OR, 0.40; 95% CI, 0.24–0.97). Risk decreased linearly with increased frequency and duration of use [41]. A similar inverse association between use of non-steroidal anti-inflammatory drugs and oesophageal squamous-cell carcinoma has been reported [51] and [52].
5. Helicobacter pylori
H. pylori is a gram-negative bacterium that persistently colonizes the human stomach and causes gastric cancer [53]. In contrast, epidemiological studies have consistently observed an inverse association with oesophageal adenocarcinoma. Two recent meta-analyses both reported over 40% lower risk of oesophageal adenocarcinoma in persons infected with H. pylori[45] and [46]. Epidemiological studies have not shown an association between H. pylori infection and oesophageal squamous-cell carcinoma [54] and [55].
6. Summary
The epidemiology of the two main subtypes of oesophageal cancer is very different. While the incidence of oesophageal adenocarcinoma continues to rise in the United States and other western populations, the incidence of oesophageal squamous-cell carcinoma continues to decline. The main risk factors for oesophageal adenocarcinoma are symptoms of gastro-oesophageal reflux disease, obesity and cigarette smoking (Table 2). Use of aspirin and nonsteroidal anti-inflammatory drugs and infection with H. pylori are associated with a reduced risk of oesophageal adenocarcinoma. Increasing evidence suggests that these risk factors confer equivalent risk for men and women and thus do not explain the sex disparity for oesophageal adenocarcinoma. We have limited data on risk factors for oesophageal adenocarcinoma and Barrett's oesophagus in non-white populations and it is unknown why oesophageal adenocarcinoma occurs more frequently in whites than non-whites [56]. Most cases of oesophageal adenocarcinoma arise from Barrett's oesophagus; consequently, patients with Barrett's oesophagus are entered into a program of periodic endoscopic surveillance. However, the survival benefit associated with long-term surveillance for these patients remains unclear. Efforts are underway to derive risk models that identify persons at greatest risk for oesophageal adenocarcinoma [57], [58], [59], [60], and [61]. These models offer promise; however, they need to be externally validated before being considered for clinical application.
|Risk factor
|Direction of association
|Oesophageal adenocarcinoma
|Oesophageal squamous-cell carcinoma
|Barrett's oesophagus
|Male sex
|White ethnicity
|Gastro-oesophageal reflux disease
|Cigarette smoking
|Nonsteroidal anti-inflammatory drugs
|Helicobacter pylori
Conflicts of interest
I have no conflicts of interest.
Authorship contribution
APT performed all analyses and drafted the manuscript.
- [1] J. Ferlay, I. Soerjomataram, M. Ervik, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D.M. Parkin, D. Forman, F. Bray, GLOBOCAN 2012 v1.1, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer. (2014). Available from: http://globocan.iarc.fr, accessed on 16/01/2015.
- [2] M. Arnold, N. Pandeya, G. Byrnes, A.G. Renehan, G.A. Stevens, M. Ezzati, et al. Global burden of cancer attributable to high body-mass index in 2012: a population-based study. Lancet Oncol.. 2015;16:36-46 Crossref
- [3] H. Pohl, H.G. Welch. The role of overdiagnosis and reclassification in the marked increase of esophageal adenocarcinoma incidence. J. Natl. Cancer Inst.. 2005;97:142-146 Crossref
- [4] A.P. Thrift, D.C. Whiteman. The incidence of esophageal adenocarcinoma continues to rise: analysis of period and birth cohort effects on recent trends. Ann. Oncol.. 2012;23:3155-3162 Crossref
- [5] G. Edgren, H.O. Adami, E. Weiderpass, O. Nyren. A global assessment of the oesophageal adenocarcinoma epidemic. Gut. 2013;62:1406-1414 Crossref
- [6] L.S. Engel, W.H. Chow, T.L. Vaughan, M.D. Gammon, H.A. Risch, J.L. Stanford, et al. Population attributable risks of esophageal and gastric cancers. J. Natl. Cancer Inst.. 2003;95:1404-1413 Crossref
- [7] C.M. Olsen, N. Pandeya, A.C. Green, P.M. Webb, D.C. Whiteman. Population attributable fractions of adenocarcinoma of the esophagus and gastroesophageal junction. Am. J. Epidemiol.. 2011;174:582-590 Crossref
- [8] J. Ronkainen, P. Aro, T. Storskrubb, S.E. Johansson, T. Lind, E. Bolling-Sternevald, et al. Prevalence of Barrett's esophagus in the general population: an endoscopic study. Gastroenterology. 2005;129:1825-1831 Crossref
- [9] F. Hvid-Jensen, L. Pedersen, A.M. Drewes, H.T. Sorensen, P. Funch-Jensen. Incidence of adenocarcinoma among patients with Barrett's esophagus. N. Engl. J. Med.. 2011;365:1375-1383 Crossref
- [10] T.K. Desai, K. Krishnan, N. Samala, J. Singh, J. Cluley, S. Perla, et al. The incidence of oesophageal adenocarcinoma in non-dysplastic Barrett's oesophagus: a meta-analysis. Gut. 2012;61:970-976 Crossref
- [11] D.A. Corley, K. Mehtani, C. Quesenberry, W. Zhao, J. de Boer, N.S. Weiss. Impact of endoscopic surveillance on mortality from Barrett's esophagus-associated esophageal adenocarcinomas. Gastroenterology. 2013;145:312-319
- [12] S.K. Bhat, D.T. McManus, H.G. Coleman, B.T. Johnston, C.R. Cardwell, U. McMenamin, et al. Oesophageal adenocarcinoma and prior diagnosis of Barrett's oesophagus: a population-based study. Gut. 2015;64:20-25 Crossref
- [13] D.C. Whiteman. Does a prior diagnosis of Barrett's oesophagus influence risk of dying from oesophageal adenocarcinoma. Gut. 2015;64:5-6 Crossref
- [14] R.E. Verbeek, M. Leenders, F.J. Ten Kate, R. van Hillegersberg, F.P. Vleggaar, J.W. van Baal, et al. Surveillance of Barrett's esophagus and mortality from esophageal adenocarcinoma: a population-based cohort study. Am. J. Gastroenterol.. 2014;109:1215-1222 Crossref
- [15] H.B. El-Serag, A.D. Naik, Z. Duan, M. Shakhatreh, A. Helm, A. Pathak, et al. Surveillance endoscopy is associated with improved outcomes of oesophageal adenocarcinoma detected in patients with Barrett's oesophagus. Gut. 2015; [Epub ahead of print]
- [16] H. Pohl, O. Pech, H. Arash, M. Stolte, H. Manner, A. May, et al. Length of Barrett's oesophagus and cancer risk: implications from a large sample of patients with early oesophageal adenocarcinoma. Gut. 2016;65:196-201
- [17] F. Kastelein, S.H. van Olphen, E.W. Steyerberg, M.C. Spaander, M.J. Bruno. Impact of surveillance for Barrett's oesophagus on tumour stage and survival of patients with neoplastic progression. Gut. 2016;65:196-201
- [18] N. Pandeya, C.M. Olsen, D.C. Whiteman. Sex differences in the proportion of esophageal squamous cell carcinoma cases attributable to tobacco smoking and alcohol consumption. Cancer Epidemiol.. 2013;37:579-584 Crossref
- [19] P.R. Taylor, C.C. Abnet, S.M. Dawsey. Squamous dysplasia-the precursor lesion for esophageal squamous cell carcinoma. Cancer Epidemiol. Biomarkers Prev.. 2013;22:540-552 Crossref
- [20] N. Howlader, A.M. Noone, M. Krapcho, J. Garshell, D. Miller, S.F. Altekruse, C.L. Kosary, Ruhl J Yu M, Z. Tatalovich, A. Mariotto, D.R. Lewis, H.S. Chen, E.J. Feuer, K.A. Cronin. SEER Cancer Statistics Review, 1975–2011. (National Cancer Institute, Bethesda, MD, 2013) http://seer.cancer.gov/csr/1975_2011/ based on November 2013 SEER data submission, posted to the SEER web site, April 2014
- [21] Surveillance Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) SEER*Stat Database: Incidence − SEER 18 Regs Research Data + Hurricane Katrina Impacted Louisiana Cases, Nov 2014 Sub (1973–2012 varying) − Linked To County Attributes − Total U.S., 1969–2013Counties, National Cancer Institute, DCCPS, Surveillance Research Program, Surveillance Systems Branch, released April 2015, based on the November 2014 submission.
- [22] H. Nordenstedt, H. El-Serag. The influence of age, sex, and race on the incidence of esophageal cancer in the United States (1992–2006). Scand. J. Gastroenterol.. 2011;46:597-602 Crossref
- [23] M.B. Cook, W.H. Chow, S.S. Devesa. Oesophageal cancer incidence in the United States by race, sex, and histologic type, 1977–2005. Br. J. Cancer. 2009;101:855-859 Crossref
- [24] A.P. Thrift, H.B. El-Serag. Sex and racial disparity in incidence of esophageal adenocarcinoma: observations and explanations. Clin. Gastroenterol. Hepatol.. 2015; [Epub ahead of print]
- [25] J. Lagergren, R. Bergstrom, A. Lindgren, O. Nyren. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N. Engl. J. Med.. 1999;340:825-831 Crossref
- [26] M.B. Cook, D.A. Corley, L.J. Murray, L.M. Liao, F. Kamangar, W. Ye, et al. Gastroesophageal reflux in relation to adenocarcinomas of the esophagus: a pooled analysis from the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON). PLoS One. 2014;9:e103508 Crossref
- [27] A.P. Thrift, J.R. Kramer, Z. Qureshi, P.A. Richardson, H.B. El-Serag. Age at onset of GERD symptoms predicts risk of Barrett's esophagus. Am. J. Gastroenterol.. 2013;108:915-922 Crossref
- [28] N. Yoshida. Inflammation and oxidative stress in gastroesophageal reflux disease. J. Clin. Biochem. Nutr.. 2007;40:13-23 Crossref
- [29] M.B. Cook, F. Kamangar, D.C. Whiteman, N.D. Freedman, M.D. Gammon, L. Bernstein, et al. Cigarette smoking and adenocarcinomas of the esophagus and esophagogastric junction: a pooled analysis from the international BEACON consortium. J. Natl. Cancer Inst.. 2010;102:1344-1353 Crossref
- [30] N. Pandeya, G.M. Williams, S. Sadhegi, A.C. Green, P.M. Webb, D.C. Whiteman. Associations of duration, intensity, and quantity of smoking with adenocarcinoma and squamous cell carcinoma of the esophagus. Am. J. Epidemiol.. 2008;168:105-114 Crossref
- [31] N. Pandeya, G. Williams, A.C. Green, P.M. Webb, D.C. Whiteman. Alcohol consumption and the risks of adenocarcinoma and squamous cell carcinoma of the esophagus. Gastroenterology. 2009;136:1215-1224
- [32] A. Prabhu, K.O. Obi, J.H. Rubenstein. The synergistic effects of alcohol and tobacco consumption on the risk of esophageal squamous cell carcinoma: a meta-analysis. Am. J. Gastroenterol.. 2014;109:822-827 Crossref
- [33] S. Singh, A.N. Sharma, M.H. Murad, N.S. Buttar, H.B. El-Serag, D.A. Katzka, et al. Central adiposity is associated with increased risk of esophageal inflammation, metaplasia, and adenocarcinoma: a systematic review and meta-analysis. Clin. Gastroenterol. Hepatol.. 2013;11:1399-1412
- [34] W.D. Hazelton, K. Curtius, J.M. Inadomi, T.L. Vaughan, R. Meza, J.H. Rubenstein, et al. The role of gastroesophageal reflux and other factors during progression to esophageal adenocarcinoma. Cancer Epidemiol. Biomarkers Prev.. 2015;24:1012-1023 Crossref
- [35] C.Y. Kong, K.J. Nattinger, T.J. Hayeck, Z.B. Omer, Y.C. Wang, S.J. Spechler, et al. The impact of obesity on the rise in esophageal adenocarcinoma incidence: estimates from a disease simulation model. Cancer Epidemiol. Biomarkers Prev.. 2011;20:2450-2456 Crossref
- [36] S. Kroep, I. Lansdorp-Vogelaar, J.H. Rubenstein, V.E. Lemmens, E.B. van Heijningen, N. Aragones, et al. Comparing trends in esophageal adenocarcinoma incidence and lifestyle factors between the United States, Spain, and the Netherlands. Am. J. Gastroenterol.. 2014;109:336-343 Crossref
- [37] R.J. Adams, S. Appleton, D.H. Wilson, A.W. Taylor, E. Dal Grande, C. Chittleborough, et al. Population comparison of two clinical approaches to the metabolic syndrome: implications of the new International Diabetes Federation consensus definition. Diabetes Care. 2005;28:2777-2779 Crossref
- [38] X. Yang, U. Smith. Adipose tissue distribution and risk of metabolic disease: does thiazolidinedione-induced adipose tissue redistribution provide a clue to the answer. Diabetologia. 2007;50:1127-1139 Crossref
- [39] C. Hoyo, M.B. Cook, F. Kamangar, N.D. Freedman, D.C. Whiteman, L. Bernstein, et al. Body mass index in relation to oesophageal and oesophagogastric junction adenocarcinomas: a pooled analysis from the International BEACON Consortium. Int. J. Epidemiol.. 2012;41:1706-1718 Crossref
- [40] A. Steffen, J.M. Huerta, E. Weiderpass, H.B. Bueno-de-Mesquita, A.M. May, P.D. Siersema, et al. General and abdominal obesity and risk of esophageal and gastric adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition. Int. J. Cancer. 2015;137:646-657 Crossref
- [41] B. Lindkvist, D. Johansen, T. Stocks, H. Concin, T. Bjorge, M. Almquist, et al. Metabolic risk factors for esophageal squamous cell carcinoma and adenocarcinoma: a prospective study of 580,000 subjects within the Me-Can project. BMC Cancer. 2014;14:103 Crossref
- [42] L. Yang, G.A. Colditz. Prevalence of overweight and obesity in the United States, 2007–2012. JAMA Intern. Med.. 2015;175:1412-1413 Crossref
- [43] H. El-Serag. The association between obesity and GERD: a review of the epidemiological evidence. Dig. Dis. Sci.. 2008;53:2307-2312 Crossref
- [44] A.P. Thrift, N.J. Shaheen, M.D. Gammon, L. Bernstein, B.J. Reid, L. Onstad, et al. Obesity and risk of esophageal adenocarcinoma and Barrett's esophagus: a Mendelian randomization study. J. Natl. Cancer Inst.. 2014;106:dju252 Crossref
- [45] M.B. Cook, N.D. Freedman, M. Gamborg, T.I. Sorensen, J.L. Baker. Childhood body mass index in relation to future risk of oesophageal adenocarcinoma. Br. J. Cancer. 2015;112:601-607 Crossref
- [46] Z. Levi, J.D. Kark, A. Shamiss, E. Derazne, D. Tzur, L. Keinan-Boker, et al. Body mass index and socioeconomic status measured in adolescence, country of origin, and the incidence of gastroesophageal adenocarcinoma in a cohort of 1 million men. Cancer. 2013;119:4086-4093 Crossref
- [47] T.L. Vaughan, S. Davis, A. Kristal, D.B. Thomas. Obesity, alcohol, and tobacco as risk factors for cancers of the esophagus and gastric cardia: adenocarcinoma versus squamous cell carcinoma. Cancer Epidemiol. Biomarkers Prev.. 1995;4:85-92
- [48] P.H. Lahmann, N. Pandeya, P.M. Webb, A.C. Green, D.C. Whiteman. Body mass index, long-term weight change, and esophageal squamous cell carcinoma: is the inverse association modified by smoking status. Cancer. 2012;118:1901-1909 Crossref
- [49] N.D. Freedman, L.J. Murray, F. Kamangar, C.C. Abnet, M.B. Cook, O. Nyren, et al. Alcohol intake and risk of oesophageal adenocarcinoma: a pooled analysis from the BEACON Consortium. Gut. 2011;60:1029-1037
- [50] L.M. Liao, T.L. Vaughan, D.A. Corley, M.B. Cook, A.G. Casson, F. Kamangar, et al. Nonsteroidal anti-inflammatory drug use reduces risk of adenocarcinomas of the esophagus and esophagogastric junction in a pooled analysis. Gastroenterology. 2012;142:442-452
- [51] S. Sadeghi, C.J. Bain, N. Pandeya, P.M. Webb, A.C. Green, D.C. Whiteman. Aspirin, nonsteroidal anti-inflammatory drugs, and the risks of cancers of the esophagus. Cancer Epidemiol. Biomarkers Prev.. 2008;17:1169-1178 Crossref
- [52] D.C. Farrow, T.L. Vaughan, P.D. Hansten, J.L. Stanford, H.A. Risch, M.D. Gammon, et al. Use of aspirin and other nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric cancer. Cancer Epidemiol. Biomarkers Prev.. 1998;7:97-102
- [53] J. Parsonnet, G.D. Friedman, D.P. Vandersteen, Y. Chang, J.H. Vogelman, N. Orentreich, et al. Helicobacter pylori infection and the risk of gastric carcinoma. N. Engl. J. Med.. 1991;325:1127-1131 Crossref
- [54] S. Nie, T. Chen, X. Yang, P. Huai, M. Lu. Association of Helicobacter pylori infection with esophageal adenocarcinoma and squamous cell carcinoma: a meta-analysis. Dis. Esophagus. 2014;27:645-653 Crossref
- [55] F.J. Xie, Y.P. Zhang, Q.Q. Zheng, H.C. Jin, F.L. Wang, M. Chen, et al. Helicobacter pylori infection and esophageal cancer risk: an updated meta-analysis. World J. Gastroenterol.. 2013;19:6098-6107 Crossref
- [56] T.H. Nguyen, A.P. Thrift, D. Ramsey, L. Green, Y.H. Shaib, D.Y. Graham, et al. Risk factors for Barrett's esophagus compared between African Americans and non-Hispanic Whites. Am. J. Gastroenterol.. 2014;109:1870-1880 Crossref
- [57] A.P. Thrift, B.J. Kendall, N. Pandeya, D.C. Whiteman. A model to determine absolute risk for esophageal adenocarcinoma. Clin. Gastroenterol. Hepatol.. 2013;11:138-144
- [58] A.P. Thrift, B.J. Kendall, N. Pandeya, T.L. Vaughan, D.C. Whiteman. A clinical risk prediction model for Barrett esophagus. Cancer Prev. Res. (Phila). 2012;5:1115-1123
- [59] J.H. Rubenstein, H. Morgenstern, H. Appelman, J. Scheiman, P. Schoenfeld, L.F. McMahon Jr., et al. Prediction of Barrett's esophagus among men. Am. J. Gastroenterol.. 2013;108:353-362 Crossref
- [60] A.P. Thrift, J.M. Garcia, H.B. El-Serag. A multibiomarker risk score helps predict risk for Barrett's esophagus. Clin. Gastroenterol. Hepatol.. 2014;12:1267-1271 Crossref
- [61] J.H. Rubenstein, A.P. Thrift. Risk factors and populations at risk: selection of patients for screening for Barrett's oesophagus. Best Pract. Res. Clin. Gastroenterol.. 2015;29:41-50 Crossref
Department of Medicine and Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas
⁎ Fax: +1 7137983658.
Article information
DOI: 10.1016/j.canep.2016.01.013
© 2016 Elsevier Ltd, All rights reserved.


text:
- Parent Category: News
Silver Alert for missing Cedar Lake, IN man
Police in Cedar Lake, IN need help in locating a missing adult man.
63-year-old Larry Stover is a white male, 5 feet 7 inches tall, weighing 170 pounds with brown hair and brown eyes.
He was last seen Tuesday, June 28 at 7 pm in Cedar Lake.
He's believed to be in danger and in need of medical attention. He was last seen wearing a gray T-shirt and jeans.
Larry Stover is believed to be traveling in a blue with purple tint 1995 Ford F150 with Indiana license plate D878NC.
Any information concerning Larry Stover should be passed on to Cedar Lake Police at 219-374-5416.


text:
The Motorcycle Diaries (2002), dir. Walter Salles
The Motorcycle Diaries (2002), dir. Walter Salles
Gael García Bernal in The Motorcycle Diaries (2004)
Gael García Bernal in The Motorcycle Diaries (2004)
Diarios de motocicleta (2004)
The Motorcycle Diaries (2004) dir. Walter Salles
HARDKNOTT PASS, LAKE DISTRICT, ENGLAND - photography: James Green - text: Julia LaPalme - Motorcyclist May / June 2017
You can take me on a ride any day ;)
Vans Girls' Catskills Moto Diaries // Babes Ride Out: Nina Kaplan
Look up the word "wanderlust" in the dictionary, and we're pretty sure you'd come across a photo of moto-babe, Nina Kaplan. Her infectious smile, and adventurous spirit make Nina the ultimate road warrior to add to your travel crew, and time-and-time again she has proven to be one of the most adventurous women we've ever met. Just like us, Nina traveled from California to attend Babes Ride Out East Coast, and we were excited to catch up with this ball of positive energy in the humid heat of Catskill, New York. Get to know more about Nina, and learn how motorcycles have changed her life, and the advice she has for girls interested in riding.
Diarios de motocicleta (2004)
"How is it possible to feel nostalgia for a world I never knew?"
The Motorcycle Diaries (2004) dir. Walter Salles
Interview with Gael García Bernal for Diarios de Motocicleta (2004).
The Hollywood Reporter
February 20, 2017
During college, Lin-Manuel Miranda and a friend used to improvise interpretative dance tributes to best picture nominees at their annual Oscar party. "It was a lot of breathing and rolling around," recalls the creator of the Broadway smash Hamilton. "We had a great Seabiscuit dance one year."
For the New York-born son of Puerto Rican parents — his father a political consultant, his mother a psychologist — it was just another phase of a lifelong fascination with the Oscars that began when he was growing up in the Inwood section of Manhattan, playing and replaying the telecasts that his family recorded on their VCR. At 37, Miranda is about to cross the threshold from superfan to participant: "How Far I'll Go," which he wrote for the Disney film Moana, is nominated for original song, and on Feb. 26, Miranda (with his mother) will attend his first Academy Awards.
It's an auspicious step in a career that will see him star with Emily Blunt and Colin Firth in Disney's 2018 Mary Poppins Returns and collaborate with composer Alan Menken on the studio's live-action The Little Mermaid, one of Miranda's favorite films and, he reveals here, the gateway to his Oscars obsession.
My brain is a compendium of Oscar moments: Tom Hanks' beautiful acceptance speech when he won best actor for Philadelphia in 1994. Roberto Benigni climbing over chairs and wanting to make love to everybody in the world when Life Is Beautiful won best foreign-language film in 1999. Kim Basinger presenting in 1990 and telling the audience that one of the best films of the year, Do the Right Thing, was not nominated. For her to take a stand, 25 years before #OscarsSoWhite, was incredible — and impressive because time has shown the prescience of that film.
I expect we'll see more of that this year. It's a political time, so I imagine the Oscars will look exactly like your Twitter or Facebook feed. Why should we ignore for three hours what we're talking about 24 hours a day?
The Oscars were always a family affair when I was a kid. One sort of unintentional tradition we had every year was during the "In Memoriam" part of the show. My family called it the "She died?" section because my dad, who is pop culture-oblivious, would always go, "She died? He died? She died?!" the whole time. So, it was very sad and yet also very funny watching my dad catch up.
When I was a kid, the Oscars felt like this impossibly larger-than-life thing. The first time I felt like I had a horse in the race was in 1990. I was 10, and The Little Mermaid was up for best song and best score. They did that crazy "Under the Sea" number with the late, great Geoffrey Holder and dudes in scuba outfits tap-dancing with flippers. We had a tradition of recording the show on our VHS, and I must have watched it a million and a half times.
There was also an amazing Chuck Workman montage at the beginning of the show that depicted 100 years of filmmaking with classic scores. I was already in love with movies, but this was the most beautiful thing I'd ever seen in my life.
That was the period when Billy Crystal was hosting, and I would memorize his musical spoofs of the year's top films. He did them with Marc Shaiman, whom I'm working with right now on Mary Poppins Returns… I was a huge fan of those moments and musical numbers — they showed a genuine love of movies while still poking fun at them. I may also be the only person in America who laughed his ass off to "Uma, Oprah. Oprah, Uma." David Letterman's commitment to that bit was enough to put it over the top for me. He didn't care if no one got it. In his head, it was funny.
Hosting the Oscars is not a thing I would ever want to do… You always have to do this dance as a host: You're playing to a billion people at home, and you're playing to anxious contestants in a room, and that's an insanely hard thing to divide. It's the most thankless task in the world. I have a pretty healthy ego, but it does not extend in that direction. I'd much rather be the guy writing the opening tune than having to deliver it.
Another Oscar moment that really stuck with me was when Whoopi won her best supporting actress for Ghost. I'll never forget, at the top of her acceptance speech she said, "Ever since I was a little kid, I wanted this," which is so rare. Then she said, "As a little kid, I lived in the projects, and you're the people I watched. You're the people who made me want to be an actor." For me, it was like she was saying, "If you want this, you can get it, too. I'm proof that you can."
I had been seeing myself in this world since I was old enough to do anything, and it was as if she reached through the screen to talk to me. I was that kid. Even my mother used to say, "Remember what Whoopi said."
That speech was the inspiration for the opening song I co-wrote for Neil Patrick Harris, "Bigger," for the 2013 Tony Awards:
There's a kid in the middle of nowhere sitting there, living for Tony performances singin' and flippin' along with the Pippins and Wickeds and Kinkys, Matildas and Mormonses / So we might reassure that kid and do something to spur that kid / 'Cause I promise you all of us up here tonight, We were that kid and now we're bigger
Another of my favorite moments was in 2005, when they had Antonio Banderas sing "Al Otro Lado Del Rio" from The Motorcycle Diaries, which was nominated for best song. And then when Jorge Drexler, who composed it, won, he went onstage and sang it, like, "This is how it really goes." It was so funny and ballsy and great. I'm happy whenever Latinos win anything, so I was thrilled by both performances.
I can't tell you what it feels like in that room because this will be my first time at the Oscars, but I can tell you why the Oscars matter. It's a night when the arts and artists are formally honored, and this recognition is seen by millions of people across the country and around the world. The show inspires people to keep pursuing their craft, or to seek out the nominated films or the overall body of work of the nominees, and through that exposure, people gain a greater appreciation of what the art of filmmaking brings to our culture.
Motorcycle Diaries (Walter Salles, 2004)
Gael García Bernal in The Motorcycle Diaries
This isn't a tale of heroic feats. It's about two lives running parallel for a while, with common aspirations and similar dreams.
The Motorcycle Diaries (2004)


text: Initially the phone cover looked as it was described but quickly loads of the sparkles startled to fall off. Long term its going to become very tatty. I'm sure it will continue to provide protection for my phone but it looks horrible and feels worse to the touch. Considering how much it cost, I'm not very impressed.


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AnalogX MaxMem (free) promises to make the most out of your RAM by regularly releasing memory that your system no longer needs. Thus, MaxMem should speed up your PC for free.
In that way, it says, MaxMem ensures that your PC and programs get the maximum amount of memory they need, for top performance. "It says...?" asks the skeptical reader. Read on.
MaxMem monitors your system, and when your free memory reaches a certain low threshold, it automatically frees up memory. You can set the thresholds, and also tell the program how aggressive it should be about managing your memory.
Monitor your PC with PC Performance Monitor
Upgrades news, advice and reviews
There's a fair amount of controversy over whether programs like MaxMem really work or are needed, because Windows over the years has gotten much better at memory management than it used to be.
In my tests, we didn't find that the program sped up my PC, which is a Quad Core PC running at 2.4GHz and with 2GB of RAM. And when we told the program to use its aggressive mode, the situation worsened: our programs became slow and unresponsive.
However, MaxMem may perform differently from PC to PC.
MaxMem: Specs
- Windows 2000/9.x/Me/XP/Vista
- 300kb
- Windows 2000/9.x/Me/XP/Vista
- 300kb
Given that MaxMem's free - and that it uninstalled cleanly from our tester PC - you might want to give it a try. As the saying goes, your mileage may vary.


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One Direction's Niall Horan and Liam Payne Reunite
Niall Horan and Liam Payne had a mini reunion backstage at the ZPL Birthday Bash concert in Indianapolis.
Niall Horan and Liam Payne had a mini reunion backstage at the ZPL Birthday Bash concert in Indianapolis.
Liam Payne is giving fans hope that One Direction will reunite again.
One Direction will be making a cameo on an episode of 'Family Guy,' courtesy of Liam Payne and Louis Tomlinson.
Between Demi Lovato, Chris Hemsworth and Liam Payne, plenty of celebs celebrate August birthdays.
Liam Payne said, "We went Beyonce-style which was cool, being a musical diva and just dropping songs."
Whether it's Liam Payne sharing a pic from Machu Pichu, Lea Michele sunning in the bluest water ever or Bella Thorne posing by an elephant (NBD), we can't help but be insanely envious of their travels.
One Direction's Liam Payne has taken to Twitter to apologize for posing for a photo in which he's pictured doing something pretty unsafe: standing on the ledge of a building, more than 360 feet up.
Now that's what we call a trophy, a relic and a memento that is priceless. Some crazed Directioner has made off with a pair of One Direction cutie Liam Payne's underwear. Say what?
Every other week, it seems, a British tabloid claims that a member of One Direction is leaving the band for one reason or another.


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The Insider Picks team writes about stuff we think you'll like. Business Insider has affiliate partnerships, so we may get a share of the revenue from your purchase.
Anna_Pustynnikova / ShutterstockThe summer season brings with it the opportunity to enjoy refreshing adult beverages out in the sunshine.
At beach parties across the coasts and barbecues across the country, people are kicking back to relax with their favorite alcohols, and while Budweiser would like you to believe that drinking beer is the most American way to self-inebriate in the summertime, there are also plenty of liquor drinks just as capable.
Personally, I am much more proficient at the art of drinking drinks than making them, so in my experience it has always been best to keep my concoctions as simple as possible.
Thus, below, I am listing some of the best-tasting and easiest cocktails to make at your upcoming outdoor bashes; they're mostly simple and delicious combinations of citrus, liquor, and ice. There's a drink for every type of liquor, so whether you prefer whiskey or gin, there should be something here to please. And thanks to our friends at Drizly, those lucky enough to live in their coverage areas can have the necessary ingredients delivered straight to their door.
Cheers to summer living.


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Now Playing
Mask Off Future
Here's everything you need to know about 'Trap Queen' rising star Fetty Wap, who's making waves around the world.
Following leaked sex tape footage appearing to show Fetty Wap with model Alexis Sky, both parties have legally warned each other to take it down. Fetty Wap's ex-girlfriend Masika Kalysha has since accused her of "wanting to be like Kim Kardashian so bad".
Masika took to Twitter, posting this photo of herself (left) to make the announcement that she was 6 months pregnant with Fetty's baby. However, Fetty took to Twitter not long after to deny the allegations, writing; "Bitches posting pics now the world going crazy. She need a come up I understand that career lookin bad."
According to TMZ, the 'Trap Queen' rapper was fitted with 20 porcelain veneers at a staggering $4,000 per tooth! Picture: Instagram
Poor Fetty, the number one question that he must get tired of having to answer is 'What happened to your eye?' So let's get this out the way first. "I tell everybody it's nothing, because it's really nothing to me," he told Shade 45's DJ Self. "What happened is, when I was little I had gotten into a little accident and it gave me congenital glaucoma in both of my eyes. The doctor saved one, I was blessed to still have my vision. That's it. That's the story."
"Fetty is money… Wap is from Gucci Mane [nickname] Guwop." As Fetty explains in an interview with Global Grind, 'Fetty' is slang for money and 'Wap' is a tribute to his idol, Alabama rapper Gucci Mane, who is also referred to as Guwop. [Picture credit: Getty]
Fetty was born Willie Maxwell. As he explained in an interview with Global Grind, he was named after his grandfather.
If you've been listening to Fetty's smash-hit "Trap Queen" as many times as we have, you'll know it opens with the ad-lib "Remy Boyz / 1738". Fetty's New Jersey squad are named Remy Boyz 1738 after a premium Rémy Martin cognac. "1738 is the finest liquor in the urban district. If you go to the liquor store and you get a bottle of 1738, it's going to be the most expensive Remy… And that's what we are, we're the finest, we're the best," Fetty explained to VladTV.
"Paterson built Fetty Wap as an artist, I just built my name and my brand. But as far as the person Fetty Wap, don't nobody know me better than the people of Paterson," said Fetty of his hometown.
Fetty started making music in 2013. He does come from a musical family: his mother sings and his brother actually wrote his second hit 'My Way'. Fetty is due to drop a self-titled mixtape this year but is holding it back to build anticipation.
In an interview with Hot 97 in November, Fetty said the song was about his current partner. In another interview in March of this year, Fetty revealed that he had split from the girl he wrote the song about after she moved away to go to college.
You might be wondering who the guy that delivers the outro at the end of 'Trap Queen' is. That's Fetty friend NttDaGritt who also runs RGF Productions, the label which Fetty's signed to.
In an interview with The Breakfast Club in September, Fetty revealed that he had only recorded two songs before 'Trap Queen'. He said he didn't like the sound of his normal raps so he started singing the hook to 'Trap Queen' and stuck with it.
Kanye West even invited him to perform with him in New York.
Gucci Mane's 2006 mixtape 'Chicken Talk' is the first mixtape Fetty heard. He says that Gucci resonated with him because: "When he talk about the trap that's all we know. When we wake up in the morning, we hit the block. I just figured out my own way of doing it, I don't rap the trap I sing it in a way that people might not understand what I'm talking about but it sound good."
Fetty's dream of collaborating with his idol was fulfilled when Gucci sent him a remix of 'Trap Queen' featuring a guest verse. "When Guwop came on I lost my mind... I was screaming and running around like 'Oh sh*t, I made it'. That's like your favourite basketball player popping up at your door with a ball and new shoes. You wouldn't know what to do with yourself."
Contrary to his Wikipedia page entry, Fetty has confirmed he isn't Haitian in a Twitter post. He wears the flag as a tribute to his partner's late grandmother, who was Haitian. Fetty also explains in an interview with CivilTV that he "fell in love with the culture, people don't know what Haiti means to me."
Fetty announced in a recent interview that his album had been finished for over two months. Lyor Cohen, the person who signed him to 300 Entertainment, said he delayed the album to allow Fetty to develop as an artist.


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Awarded annually, The Chautauqua Prize draws upon Chautauqua Institution's considerable literary legacy to celebrate a book that provides a richly rewarding reading experience and to honor the author for a significant contribution to the literary arts.
Chautauqua, N.Y. (PRWEB)
April 20, 2017
Chautauqua Institution is pleased to announce six exceptional books as the 2017 finalists for The Chautauqua Prize, now in its sixth year:
"The General vs. The President: MacArthur and Truman at the Brink of Nuclear War," by H.W. Brands (Doubleday)
- "The Fortunes," by Peter Ho Davies (Houghton Mifflin Harcourt)
- "Blood River Rising: The Thompson-Crimson Feud of the 1920s," by Victoria Pope Hubbell (Iris Press)
- "Underground Airlines," by Ben H. Winters (Mulholland Books)
- "American Character: A History of the Epic Struggle Between Individual Liberty and the Common Good," by Colin Woodard (Viking)
- "The Song Poet: A Memoir of My Father," by Kao Kalia Yang (Metropolitan Books)
The winning book will be selected from this shortlist and announced in mid-May.
In "The General vs. The President," historian and Pulitzer Prize finalist H.W. Brands recounts the post-World War II struggle for power between President Harry Truman, then an unpopular neophyte, and Gen. Douglas MacArthur, a revered and successful military mind. The approaches of these two men — patience vs. audacity — collide in the pages of a book Chautauqua readers called "thoroughly researched, clearly organized and written in straight-forward prose" whose "fast-paced and colorful" details make for "an enjoyable read."
Peter Ho Davies' "The Fortunes" recasts American history through the lives of Chinese Americans and reimagines the multigenerational novel through the fractures of immigrant family experience. Readers applauded Davies' "extraordinary writing about a timely issue of otherness," calling the book, "Emotionally engaging and a clear, poignant account." Particularly lauded were Davies' characters, who, one reader said, "won my empathy, as I grieved and cheered them on in their unflagging search for identity and home."
Part historiography, part memoir and part murder investigation, Victoria Pope Hubbell's "Blood River Rising" unpacks a blood feud in rural Missouri — a clash fueled in part by a chapter of the Ku Klux Klan. The clash left two people dead in 1924, but Hubbell tells a story wider than the feud and the time period, foreshadowing fraught race relations and the lingering influence of the KKK. It is, readers said, "a wonderful, gripping and very American story," and Hubbell's methods and writing are "a credible way to tell a complicated story, where memories fail and time covers the truth."
In Ben…


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Gary in Mr Peabody and Sherman on Netflix
Gary plays a character in Mr Peabody and Sherman on Netflix. The episode is titled Alternate Universe.
You can read more about this episode and see the trailer here
Gary Stars in Camp Manna
The film stars Busey as the slightly-deranged born-again Vietnam vet who manages a Christian camp with the help of a staff of exuberant counselors, and Suttons Bay actor Luke Klein, 15, as the wayward Florida teen who lands there after the death of his parents in an alligator attack.


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ComCenter is a locally operated company serving the Sarasota/Bradenton area for over eleven years. It was founded by Bernard Croghan, who has a 25 year record of excellence as a commercial developer in Manatee County.
Our Mission
is to provide small businesses and entrepreneurs with a professional office environment, first rate meeting and communications services, and a friendly, attentive and competent staff always ready to serve.
Our Goal
is to provide our Clients the best office alternative, featuring:
- Strategic Flexibility enabling critical course changes in uncertain times.
- Lower Space Requirements resulting in lower rent.
- Shared Administrative Services resulting in lower HR costs
- Shared Furniture & Equipment, resulting in lower capital investment
- Superior Telecommunications, resulting in better connectivity with clients.
Our Team
is actually Your Team. Our job is to make you look good.
- When your clients call, we answer with a live, cheerful greeting, per your specifications.
- When your clients visit, we greet them cheerfully, offer coffee, and show them to your reserved meeting room.
- We are ready to tackle any administrative task to support your goals.
Our Community Partners
- Manatee County Chamber of Commerce
- Sponsored a chamber office in our center for 7 years.
- Sponsored many seminars and joint programs
- Sponsored Small Business Boot Camp
- Sponsored Manatee Economic Development Council for 8 years.
- Lakewood Ranch Business Alliance
- Member and Sponsor
- Host Annual Networking Social
- Provide Meeting Rooms for executive committees
- Latin Chamber of Commerce Southwest Florida
- Member and Prime Sponsor
- Provide offices and meeting rooms for executive committees
- SCORE (Service Corps of Retired Executives)
- Provide presentation and training rooms for SCORE'S Quickstart Workshop for small businesses.
- Public Art Sponsorships
- Created an Art Gallery in the ComCenter lobby specifically for Art Display
- Host regular Art Shows featuring local artists


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2013 Ford Mustang
November 16, 2011 by staff
2013 Ford Mustang, Just like back in 1969, when the next year rolled around to 1970. The Mustang Boss just mostly gained a new set of color schemes, and now, Ford is planning on doing the exact same with the 2013 Mustang Boss 302. The updates the Mustang Boss is going to receive this year will be mostly cosmetic, but I am completely happy with that decision, believe it or not. In my opinion, the original and the 2012 reintroduction were the best handling Mustang's that Ford has ever put on the market, in my honest opinion.
When it comes to differences between the 2012 and the 2013, it will be exactly the same as spotting the differences with the 69 and 70 models. The first year cars had the C-shaped side striping and the large black-out hood panels, but the 70's model and the 2013 are going to have hockey stick-like side marking and a center stripe on the hood. Just like the ones on the original Mustang Boss, the 2013 Boss will feature reflective decals.
Along with the rest of the Mustang's out there, the new Boss is going to receive some revised front and rear trim. Also, there are going to be functional vents on the bulgier hood, which terminates at a larger, more GT-500 looking grill. Last year as far as the fog lamp covers go, there were molded into the car, mostly for cosmetic purposes. However, the 2013 will come with caps that have the ability to be removed, so you can increase cooling to the engine.
Please feel free to send if you have any questions regarding this post , you can contact on
Disclaimer: The views expressed on this site are that of the authors and not necessarily that of U.S.S.POST.


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- Duration
3 hours
- Group Size
Minimum of 8 hens
- Availability
7 days a week
- Equipment
Snorkels & masks available
- Seasonal
All year round
- Dress Code
- Transport
Transfers are included.
Please note...
Please Note: This page provides a general guide to our catamaran cruise in Benidorm. We work with multiple suppliers, so please be aware that specifics may vary. Feel free to ask your Destination Specialist at the time of booking if you have any questions about this.
Photos should be referred as a guide, and can vary on your particular programme.


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BRASILIA, March 22 (Reuters) - Brazilian federal police were seeking to arrest 15 people on Tuesday as part of the corruption investigation centered on state-run oil producer Petroleo Brasileiro SA, police said.
Tuesday's operation, codenamed "Xepa", uncovered a bribe-payment scheme led by engineering conglomerate Odebrecht SA, police said in a statement. It did not give the names of the targets.
It is the 26th raid in the two-year-old corruption probe that has put top executives and political leaders in jail and has raised chances of the impeachment of President Dilma Rousseff. (Reporting by Silvio Cascione, Editing by Angus MacSwan)


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Quick Details
- Brand Name: ODM
- Compatible Brand: 5.5INCH
- Model Number: For Iphone 6plus
- Material: Polyester
- Color: Black, Gray, Green, Pink, 3 colors
- Place of Origin: Guangdong, China (Mainland)
- Product name: Lycra Armband
- Item: HSK-22
- Feature: Durable,eco-friendly, sweatproof
- Design: armband for running
- Style: OEM Printing
- Model: 5.5INCH mobile phone
- Type: Part OEM
- Size: 48.0*17.4cm
- Compatible: Iphone 6/for Iphone 6s
Packaging & Delivery
|Packaging Details
|Packaging Details: normal in PP bag or welcome to customize the private packing
Delivery Detail: 5-7working days upon all informations confirmed
|Delivery Time
|Shipped in 3 days after payment
Lycra Sport Armband
Product Features
1.Perfect fit for: Apple iPhone 6, Samsung Galaxy S6/S6 Edge/S5, your phone will fit in it with a slim case still on.
2. Sports, cycling, mountain climbing, walking trip the best choice, lightweight and slim, with additional storage cell,capable of accommodatingchange keys.
3. The transparent cover, convenient control touch screen.
4. The use of high-grade lycra material, soft and delicate, elastic, shockproof, waterproof function.
5. Double buckle, can flexibly adjust the degree of tightness, suitable for arm size:10.6 to 16.2 inches(27-41cm).
Product Description
Product Name
armband for running
Product NO
Iphone 6, Iphone 6s, Iphone 6P, universal size below 5.5inch
Compatible Brand
Any model can be done (specific conditions can contact us)
5 colors
Protection, Running, Walking, Jogging, Gym and Workout
Yes, warmly welcome OEM/ODM.( we are phone case manufacturers )
According to customer s request
Sample Time
Delivery Time
5-7 working days after all payment down.
Payment terms
T/T30% advance payment + T/T70% before shipment, L/C, Paypal, Western Union.
Product Image
Black Lycra Armband
Pink Lycra Armband
Deep Blue Lycra Armband
Green Lycra Armband
Product Details
Company and Factory Image
Packing & Shipping
Our Certificates
Why choose us?
1. We have full experience in this field, and work with the customers from Amazon/Ebay for over 3 years and Alibaba for 5 years.
2. We are direct manufacturer. High quality, competitive price and perfect service.
3. MOQ: 500 pcs for an order.Mix colors, mix models and mix quantity are accepted.
4. OEM or ODM is welcomed.
If you have any interesting, Pls contact Maggie directly!
I will try my best to service for you!


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BAPRAS Archive
The Archives were started in the 1980s by Antony Wallace, and are known as the Antony Wallace Archive. Our current Honorary Archivist is Roger Green, who follows Brian Morgan who retired from the post in 2014 having spent fifteen years overseeing and expanding the archive. Mr Morgan followed Phil Sykes and Charles Chapman in this role.
Plastic surgery records go back to at least 500 BC. The modern discipline as we know it, however, has its origins in the First World War, and there are no extant artefacts predating this period.
Accessing the Archives
The BAPRAS archives are visited by people from all over the world and anyone is welcome to view our collection. Viewings are available by appointment only. To arrange a visit, please contact the Secretariat to make an appointment with the Association archivist
The BAPRAS Archives consist of:
BAPRAS holds a number of photographs, some of which depict staff and treatment procedures from the First World War, although the majority are of plastic surgery personalities from the 1930s and the Second World War. There are some clinical photographs, and a collection of photographs taken by Mr Percy Hennell during the Second World War. The latter are of great interest due to the system of colour photography used by Hennell which helps to achieve minimal image fading. The archives are also home to a 16mm cine film from the 1930s which contains footage of several operative procedures.
BAPRAS has a collection of plastic surgery instruments, including a variety of grafting knives. Some instruments carry famous surgeons' initials, while others display various developmental designs. Notably, BAPRAS owns a set of instruments that once belonged to the German surgeon Professor Joseph, who was the pioneer of cosmetic rhinoplasty. Read more about Professor Joseph's instruments
All BAPRAS-archived instruments are available for viewing and can be accessed online here
Can you help?
If you have any experiences or knowledge of plastic surgery in the past, memories of working with or being a patient of Harold Gillies and his contempories, we would love to hear from you- please email the Secretariat


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The Court of Appeal has thrown its weight behind Lord Justice Jackson and issued a stern warning that litigators must comply with court procedures or face restrictive spending sanctions.
Lawyers said the CoA ruling handed down by the Master of the Rolls Lord Dyson today came as little surprise, with the court looking to adopt a more robust approach to case management.
The ruling was seen as a major test of the principles adopted by Lord Justice Jackson, which were implemented in April. The ruling means Andrew Mitchell MP, who is pursuing The Sun in defamation proceedings, will have his legal spend limited to the cost of filing the claim and any court fees (27 November 2013).
Eversheds partner Glenn Newberry said: "The CoA has sent a clear message to practitioners that breaches of the rules will no longer be tolerated and sanctions introduced by the Jackson reforms, however severe they may appear, will be upheld.
"There is now considerable pressure on solicitors to prepare, exchange and discuss their costs budgets in accordance with the rules, and ensure those budgets are monitored and adhered to as the case progresses."
Vannin Capital consultant Nick Rowles-Davis agreed, adding: "It strongly underlines to all lawyers the need to take budgeting requirements seriously, whether they are a claimant or defendant – the court is showing who is boss when it comes to costs budgeting and the general view is these rules will be taken seriously."
Norton Rose Fulbright partner Kirsty Hick continued: "The CoA has sent out a very clear and unequivocal message that litigation will be conducted differently from now on – compliance with the rules will be enforced more strictly, with no relief unless the default is trivial or there is a 'good reason'."
Atkins Thomson, which is representing Mitchell, had unsuccessfully attempted to have the order lifted in the summer, instructing Temple Garden Chambers' Simon Browne QC. He told the court Atkins Thomson was a two-partner firm compared with heavyweights Simons Muirhead & Burton, which is acting for The Sun publishers News Group Newspapers. Two of three trainees at the firm were on maternity leave and a senior associate, who would normally deal with such issues, has recently left the firm. Furthermore, the second partner Mark Thomson is currently leading a raft of phone hacking claims against News International.
Practico managing director Andy Ellis commented: "It was evident that mere inadvertence or pressure of work – unkindly described by some as 'the dog ate my homework' form of excuse – will not get you home when seeking relief from sanctions.
"The new culture isn't zero tolerance – the court was clear that it is not concerned with trivial breaches. But the wriggle room is now extremely narrow when delay will result and especially if the court is inconvenienced. It's also telling that the first major decision that will help shape the administration of civil justice post-Jackson concerned compliance with costs management. There have been whispers that the courts' commitment to budgeting might be waning – Mitchell shows that this is far from the case."
Hardwicke Chambers barrister Colm Nugent added: "Crucially, there is to be a shift away from doing justice in the individual case. The focus is now on the new approach to compliance, not exclusively on justice between the parties."


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I want to increase website conversion for my website. I am spending a lot for pay-per-click and my website conversion just isn't what it needs to be to justify the expense. Does anyone know of a site that has some simple tips on how to help increase website conversion rates?
I need help with an econometrics project I am about to embark on. I need a simple multivariate economic relationship to analyse and test, I've been looking around but I've found it remarkably hard to find a simple one where I would be able to find the relevant data/statistics, most relationships seem to be univariate. [...]
Search Engine Optimizer, Someone Told me that i have to Make too many things, that Related with Programming and Maths Also, to Let google or yahoo Choosing my Website One of 10 Results that Contains the Keywords or whatever…..
can anybody tell me What Shall I Do????
Image taken on 2007-03-20 21:30:54 by funkandjazz.
Pharmahelper Pleased To Recognize Online Pharmacy Practice Standards Announced By Google Adwords
Google announces new policy which requires online pharmacy advertisers to be accredited by NABP's Verified Internet Pharmacy Practices Sites℠ (VIPPS®) program (for the US) or the Canadian International Pharmacy Association (for Canada).
Read more on PRWeb via Yahoo! News
Continue reading about Pharmahelper Pleased To Recognize Online Pharmacy Practice Standards Announced By Google Adwords
This past weekend, Network Solutions Senior Vice President Stephanie Leffler paid a visit to msnbc's "Consultants Corner", where she talked about how companies can ensure that their Web sites come out at the top of the search engines. Because being found via search engines such as Yahoo! or Google can be the difference between success [...]
Continue reading about Network Solutions Sr VP; Beginner Tips for SEO
In this video, Eric J. Hansen, Founder and CEO of website optimization firm sitespect, will preview the company's new video series on multivariate testing and behavioral targeting.
Continue reading about SiteSpect Multivariate Testing Video Series Overview
Image taken on 2007-07-30 15:16:03 by Foread.
Image taken on 2008-06-17 07:39:57 by hongxing128.
Continue reading about Ensure Website Visibility With Search Engine Optimization Slide12
I was wondering if anyone could explain in details about Google Adwords. Do you make money off of it or do you have to pay Google for specific words? What is the best way to make money from advertisements on your website? Where do you find these advertisers?
Continue reading about What is google adwords and how does it benefit your website?


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We are in the midst of a major project at work and I've been putting in many late hours to get my side of the project done. With this and that to square away, I come home dragging my feet, drained of body and mind and what's for dinner is the last thing I want to worry about.
Thank heavens for crock pots, I get to come home to the saucy goodness and melt-in-your-mouth tenderness of these slow cooker BBQ country style ribs!
My peeps, a home cooked meal can't get any easier, or better, than this! Other than the few minutes required to lightly brown the meat (totally optional but highly recommended), this is mostly a hands-off recipe.
You throw the ingredients into the pot, go about your day's business, and have the slow cooker do the work. With such minimal effort, you won't believe the mouthwatering aroma and robust flavors of these ribs.
And with from-scratch barbecue sauce to boot!
Served with generous heaps of potato salad, some tossed greens, and a chunk of a crusty loaf, these slow cooker BBQ country ribs make a wholesome dinner the whole family will surely rave about and crave for.
And boy, that sweet and tangy BBQ sauce is just begging to be sopped up! Enjoy!
- 4 pounds country style pork ribs
- Cajun seasoning to taste
- 1 tablespoon oil
- 1 onion , peeled and finely chopped
- 2 cloves garlic , peeled and minced
- 1 1/4 cups ketchup
- 1 cup brown sugar
- 1/2 cup red wine vinegar
- 2 tablespoons Worcestershire sauce
- 2 1/2 teaspoons ground mustard
- 2 teaspoons paprika
- 1 teaspoon salt
- 1 teaspoon pepper
In a bowl, combine pork ribs and Cajun seasoning to taste. Massage onto meat and let stand for about 10 to 15 minutes.
In a pan over medium heat, heat oil. Add pork in a single layer and cook, turning as needed, until lightly browned. Remove from pan and drain on paper towels.
In the crock pot, arrange meat. Add garlic and onions.
In a bowl, combine sugar, ketchup, red wine vinegar, Worcestershire sauce, ground mustard, paprika, salt and pepper. Whisk until mixture is well-blended, sugar is dissolved and spices are well-dispersed. Pour into crock pot over pork. Cook on low for about 7 to 8 hours or until meat is very tender. Serve hot.


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Everything You Always Wanted to Know About Shorting Stocks w/ Manuel Asensio, Author of "Sold Short: Uncovering Deception in the Markets"
Shorting stocks and other financial instruments can be extremely profitable… IF you know what you're doing.
In today's show, Marc shares everything you need to know to get started as a short-seller. He even brings in the "big guns," shorting pioneer Manuel Asensio. He's the author of the popular book, Sold Short: Uncovering Deception in the Markets. Topics discussed include: Manuel's skeptical approach to Wall Street… the film distribution company he's investigating now… and some areas where the SEC needs to step up in order to protect investors.
Later, Marc shares the results of last week's listener survey. The results were informative and, in a few cases, quite humorous. So be sure to listen until the end of the show for those.


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ARC Lab (Room 330, Marrs McLean Science Building)
The ARC lab's mission is to provide space, tools, and specialized guidance that fostor collaboration and exploration of new interdisciplinary approaches to the arts.
The ARC lab is a space provided by the Arts Research Coalition (ARC), an incubator for interdisciplinary collaboration, creating innovative ideas and projects in the world of art. ARC's main purpose is twofold: 1) to create art and 2) to research artistic collaboration techniques.
ARC seeks to give students, faculty, businesses, communities, and virtual entities around the world with creative opportunites and state-of-the-art facilities for collaboration on art projects. ARC's research of interdisciplinary approaches to art benefits institutes interested in diversity, teamwork, intermedia, and the design of environments that stimulate creativity.
Here are a few highlights from the equipment housed in the ARC lab:
- Mac Pro, a few iMacs, and a MacBook Pro
- 8.1 Audio System (Dynaudio BM6A MII and BM14S)
- Metric Halo LIO-8 with 8 pres
- Mackie Control Universal Pro and Control Extender Pro
- 2 Genelec 1030A & 2 Genelec 8030A
- 4 QSC K10 & 1 QSC KSub
- Korg Triton Keyboard
- ARP 2600, Hammond C3 Organ, and player piano
Comp Lab (Room 220, Roxy Grove Hall - Next door to Dr. McAllister's office)
The Comp Lab is a publishing lab for composition students to edit, print, bind, and package their compositions. It is equipped with an 11x17 duplex printer, spiral binder, and other binding necessities.
META Lab (3rd Floor of Moody Library in the Crouch Fine Arts Library)
The META Lab is a specialized instructional technology center for music applications. The lab is located in the Listening/Viewing Center of the Crouch Fine Arts Library. The lab is available for use during all regular Library hours (with a valid BearID), except when it is reserved for a class or seminar.
There are 12 student work stations in the lab, plus an instructor station, and each includes a computer and a MIDI keyboard controller. In addition to the software shared by computers in the Moody Garden Level Study Commons, the META Lab computers have the following software applications installed:
- Band-in-a-Box
- SmartMusic
- Finale
- Pyware 3D
- Audacity
- SoundHack
- Sonic Visualizer
- iLife (iPhoto, iMovie, GarageBand)
- Variations