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Shen Build Guide by Boofers
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AP < Tank
Shen Build
Ability Sequence
Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
My favourite champion of all time; Shen, Eye of Twilight. The champion that got my all the way to level 30 and then suddenly! Oh! He's nearly always banned in ranked games
Gone are the days where top lane is kept safe with nothing but a ninja in every game, the ADC and APC are saved from level 6 and the opposition top laner can't help be denied farm or be out-sustained.
But still, sometimes, the opposition do not ban him. Sometimes they forget. Sometimes, that's when they need reminding as to why Shen is the master of top lane.
Below is an explanation on why I build Shen like I do, focusing mainly on an AP tank Shen; the role he plays best.
Difference in builds leads to different items, with some core items in all.
Pure AP is just for fun.
Skill Sequence
Heavy pusher? Shadow Dash and Feint.
Trying to out-sustain you? Vorpal Blade and Feint.
Summoner Spells
Teleport: A must have with Shen
Ignite: With Shen, his biggest worry is those who can out-sustain him. Dr. Mundo's ultimate, lifesteal etc. Ignite halves healing effects and keeps you on top.
Shen is the assist master. He will get a few kills, he may even die a couple of times, but none of that matters when you've gotten 15 - 30 assists for your team, leading to the survival of many team mates with Stand United, followed by Shadow Dash.
Teamwork?! Teamwork?! Shen IS teamwork. With an ulti that saves lives and a taunt that helps escapes as well as kills. There aren't many more useful tanky players on a team than Shen.
Farming is very average for Shen, with a fairly weak melee attack 6/7 attacks (passive) and only the Vorpal Blade damaging minions in his ability set, last hitting is all Shen can hope to do at the start.
I always rush the Sunfire Cape with Shen, it makes him tankier against basic and physical attacks, gives him tons of extra health and best of all; makes minion farming as easy as standing around, looking like a ninja.
Pros / Cons
+ Sustains well
+ Good from early levels
+ Ulti is universal
+ Taunt saves lives and helps gets kills
+ Versatile player (can be played different ways, as well as jungling and can even support)
+ Saves towers easily from melee characters
+ Has a gap closer like no other
+ Is a flippin' ninja
- Doesn't do big damage
- Level 6 Stand United is weak
- Early game minion farm is weak
- That's all.


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Gun Found In Student's Backpack
Associated Press - August 16, 2013 9:47 am
Johnson County police say a handgun was found in a student's backpack outside Spring Hill High School.
A Johnson County sheriff's deputy assigned as a school resource officer was checking on a report of a student "in need of care" outside the school Thursday when the gun was found.
Spring Hill School District officials later posted a notice about the incident on the district website.
The sheriff's office says the student wasn't arrested, but was given help in obtaining mental health treatment.
Spring Hill is a community of about 5,500 residents in southern Johnson County.
Associated Press information from: The Kansas City Star
Keep promoting being a friend, lover, parent ect. of the student instead of a teacher or administrator and see what it will get you when they bring guns to school.
more words of wisdom from Iggy.
more words of wisdom from Iggy. Now an education specialist
K sal its time for Charles the imposter Sadler to be gone. As he has done before he is on here trolling breaking your rules. If he stays others will follow suit and you will be back to where you were before changing your registering.


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Forest Honey (From the Tribals of the Deep Forest) Description
Forest Honey is collected from wild beehives by groups of expert honey foragers, carrying on traditional methods. The foragers return at night to collect the honey while the bees are sleeping. They never use smoke or any other process that could cause harm to the bees, their hives, or the forest vegetation.
Our Source
Our Honey is collected from wild beehives by traditional groups of tribal honey foragers. These experts travel deep within the forests to gather the wild honey, well beyond the reach of automobiles and other pollutants.
About Our Honey
Ours is 100% raw and unheated, preserving all the delicate enzymes and health-promoting qualities. It is usually darker with a higher mineral content, and has a stronger taste and particular therapeutic benefits,is rich in minerals and complex sugar has strong antibacterial and antioxidant properties. So try this incredibly healthy and unique tasting honey and let us know what you think.
Wild Forest Honey
Why Buy Our Forest Honey
- Does not crystallize at all due to lower glucose content.
- Contains high concentration of minerals
- Possess strong flavour with a woody taste and leaves an aftertaste
- Dark color with slight green fluorescence
- Very less aroma
Difference between nectar honey and forest honey:
There are several differences between nectar honey (which is based on flowers) and forest honey:
- Composition: Forest honey variety contains high amount of minerals, complex sugars such as raffinose and melezitose and amino acids.
- Taste and color: It is dark in colour and less sweet compared to the blossom honey.
- Crystallization: Presence of complex sugars prevents it from crystallization. The high fructose to glucose ratio and less amount of water prevent it from crystallization.
Read more about Health benefits of Forest Honey


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j.j thomson model of an atom explain in dettail with pic...for my project..
In atomic physics , the Bohr model , introduced by Niels Bohr in 1913, depicts the atom as a small, positively charged nucleus surrounded by electrons that travel in circular orbits around the nucleus—similar in structure to the solar system , but with electrostatic forces providing attraction, rather than gravity . This was an improvement on the earlier cubic model (1902), the plum-pudding model (1904), the Saturnian model (1904), and the Rutherford model (1911). Since the Bohr model is a quantum-physics–based modification of the Rutherford model, many sources combine the two, referring to the Rutherford–Bohr model .
The model's key success lay in explaining the Rydberg formula for the spectral emission lines of atomic hydrogen. While the Rydberg formula had been known experimentally, it did not gain a theoretical underpinning until the Bohr model was introduced. Not only did the Bohr model explain the reason for the structure of the Rydberg formula, it also provided a justification for its empirical results in terms of fundamental physical constants.
The Bohr model is a primitive model of the hydrogen atom. As a theory, it can be derived as a first-order approximation of the hydrogen atom using the broader and much more accurate quantum mechanics, and thus may be considered to be an obsolete scientific theory. However, because of its simplicity, and its correct results for selected systems (see below for application), the Bohr model is still commonly taught to introduce students to quantum mechanics, before moving on to the more accurate but more complex valence shell atom. A related model was originally proposed by Arthur Erich Haas in 1910, but was rejected. The quantum theory of the period between Planck's discovery of the quantum (1900) and the advent of a full-blown quantum mechanics (1925) is often referred to as the old quantum theory.
Please refer to the following link
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Thomson's Atomic Model
| [J. J. Thomson's raisin bread model (plum pudding model)]
J. J. Thomson considered that the structure of an atom is something like a raisin bread, so that his atomic model is sometimes called the raisin bread model. He assumed that the basic body of an atom is a spherical object containing N electrons confined in homogeneous jellylike but relatively massive positive charge distribution whose total charge cancels that of the N electrons. The schematic drawing of this model is shown in the following figure. Thomson's model is sometimes dubbed a plum pudding model.
| [Thomson's Model and Alpha Particle Scattering]
As stated on the preceding page, Geiger and Marsden carried out an experiment in which the alpha rays were collided against a thin metal foil. Their results showed that almost all incident alpha particles penetrate the foil and go straight in forward direction but a few are scattered in very large angles.
Is it possible to explain this result by using Thomson's model? This question will be studied below, but before explaining it, let us present the answer in advance: The results of the alpha particle scattering cannot be explained by Thomson's atomic model. Thomson's raisin bread model (plum pudding model) therefore cannot be valid as an atomic model.
The reason will be explained below. Since we need somewhat detailed mathematical expressions, it will be given on the other page,
2-4-A: Alpha Particle Scattering by Thomson's model
As seen on the other page (2-4-A), we can consider that the scattering angle of the alpha particle by Thomson's model is at most 0.01 degrees.
The thickness of the metal foil in the scattering experiment of the alpha rays is about 10-6 m. When assuming that the atoms are tightly packed in the metal, there are about 10000 atoms lining up in the direction of thickness, because the size of an atom is approximately 10-10m. (See the following figure.)
When the alpha particle collides with these atoms in the metal foil 10000 times successively, the scattering angle of each individual collision in such a multiple scattering is less than 0.01 degrees as discussed above. The resultant scattering angle is obtained by an accumulation of these individual scatterings of 10000 times. One may expect that, even if the scattering angle of each individual scattering is very small like 0.01 degrees, we can have as large resultant angle as
This is however unrealistic, because the direction of each individual scattering must be random, and an accumulation of random values would give nearly zero only. So that we never obtain such a large resultant scattering angle after the multiple scattering.
Accordingly, such a large scattering angle as those obtained in Geiger and Marsden's experiment cannot be reproduced by such a multiple scattering as stated above. Thus we can conclude that Thomson's atomic model is not held.
The plum pudding model of the atom by J. J. Thomson, who discovered the electron in 1897, was proposed in 1904 before the discovery of the atomic nucleus in order to add the electron to the atomic model. In this model, the atom is composed of electrons (which Thomson still called "corpuscles", thoughG. J. Stoney had proposed that atoms of electricity be called electrons in 1894 [1] ) surrounded by a soup of positive charge to balance the electrons' negative charges, like negatively-charged "plums" surrounded by positively-charged "pudding". The electrons (as we know them today) were thought to be positioned throughout the atom, but with many structures possible for positioning multiple electrons, particularly rotating rings of electrons (see below). Instead of a soup, the atom was also sometimes said to have had a "cloud" of positive charge.
With this model, Thomson abandoned his earlier "nebular atom" hypothesis in which the atom was composed of immaterial vorticies. Now, at least part of the atom was to be composed of Thomson's particulate negative corpuscles, although the rest of the positively-charged part of the atom remained somewhat nebulous and ill-defined.
The 1904 Thomson model was disproved by the 1909 gold foil experiment, which was interpreted by Ernest Rutherford in 1911 [2] [3] to imply a very small nucleus of the atom containing a very high positive charge (in the case of gold, enough to balance about 100 electrons), thus leading to the Rutherford modelof the atom. Although gold has an atomic number of 79, immediately after Rutherford's paper appeared in 1911 Antonius Van den Broek made the intuitive suggestion that atomic number is nuclear charge. The matter required experiment to decide. Henry Moseley's work showed experimentally in 1913 (seeMoseley's law) that the effective nuclear charge was very close to the atomic number (Moseley found only one unit difference), and Moseley referenced only the papers of Van den Broek and Rutherford. This work culminated in the solar-system-like (but quantum-limited) Bohr model of the atom in the same year, in which a nucleus containing an atomic number of positive charge is surrounded by an equal number of electrons in orbital shells. Bohr had also inspired Moseley's work.
Thomson's model was compared (though not by Thomson) to a British dessert called plum pudding, hence the name. Thomson's paper was published in the March 1904 edition of the Philosophical Magazine , the leading British science journal of the day. In Thomson's view:
... the atoms of the elements consist of a number of negatively electrified corpuscles enclosed in a sphere of uniform positive electrification, ... [4]
In this model, the electrons were free to rotate within the blob or cloud of positive substance. These orbits were stabilized in the model by the fact that when an electron moved farther from the center of the positive cloud, it felt a larger net positive inward force, because there was more material of opposite charge, inside its orbit (see Gauss's law). In Thomson's model, electrons were free to rotate in rings which were further stabilized by interactions between the electrons, and spectra were to be accounted for by energy differences of different ring orbits. Thomson attempted to make his model account for some of the major spectral lines known for some elements, but was not notably successful at this. Still, Thomson's model (along with a similar Saturnian ring model for atomic electrons, also put forward in 1904 by Nagaoka after James Clerk Maxwell's model of Saturn's rings), were earlier harbingers of the later and more successful solar-system-like Bohr model of the atom.
hope dis 1 will help !!
the planetary model of an atom depicts the atom as a nucleus surrounded by revolving electrons, kind of like the solar system.
but we know that any charged body in motion radiates energy. so technically the electrons should lose energy and eventually spiral into the nucleus.
But this does not happen.
To explain that neils bohr came up with a new model of the atom with certain conditions.
Bohrs model asserts that
* The planetary model is correct
* An electron move in discrete orbits and during this it does not radiate(lose)energy.
With the growing evidence that the atom is composed of even smaller particles, attention was given to how the particles fit together. In the early 1900s J. J. Thomson reasoned that because electrons comprise only a very small fraction of the mass of an atom, they probably were responsible for an equally small fraction of the atom's size. He proposed that the atom consisted of a uniform positive sphere of matter in which the electrons were embedded, as shown in Figure 2.8. This model became known as the "plum-pudding" model, after the name of a traditional English dessert. Thomson's atomic model was very short-lived.
Figure 2.8 J. J. Thomson's "plum-pudding" model of the atom. He pictured the small electrons to be embedded in the atom much like raisins in a pudding or like seeds in a watermelon. Ernest Rutherford proved this model wrong.
hope dis 1 will help!! : )
thank u
ok then i will giv u anthr ans..
any other...i alsread ysaw htis in net..
thomson model of an antom he best experiment in future & in past
for wat?
some body give a thumps up!!!!!!
i wnt a report on it
do u want the answer for ur project or do u want to understand the model simply!!
nice ans..can u explain me Bohr's model of atom plzzz. sure thumbs up
thx..bt not satisfied...any way thx
ok wait a min.
more than dis...any way thank u very much for ur ans..
rutherford's model of an atom depicts that in an atom there are electrons which revolve around the nucleus and and radiate energy so technically the electrons should lose energy and eventually spiral into the nucleus.
but this ds not happen
To explain that neils bohr came up with a new model of the atom with certain conditions.
Bohrs model asserts that:
the electrons revolve around the nucleus but only in discrete orbits
when they revolve in discrete orbit they do not lose energy
hope u hv understood frm dis 1!!
ok i wil try 2 give u another anser!! : ))


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The using of the old doors is a creative and trendy. With the new trends of recycling old and unusable items, you save this pieces and they get a new second life and a different roll. The old door is one of the items that you can give them a new roll with little bit creativity and interesting idea to be redesigned into countless practical elements.
Everybody see the doors like a simple barrier between two rooms, outside world and the warm private home decor. But this items can transform in so many items or furniture. You just need to have creativity and this pieces can be good benefit in the home or in the yard.
Depending on the type of the door and the material, with or without glass or windows, metal or wooden. You can make it by your self a dining table, shelves or drawers, framework for a mirror, simple and interesting decoration of the wall and many more things.
This ideas are very cheap and unique, you just need old doors and little bit time to make them and enjoy the final result. We have interesting ideas with different items in the category DIY check them and start to make some trendy and interesting design project for your home.


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The summer is coming and it is a season for women to show off their body and skin. However, the imperfections of the body shape impede women to do it. Women with different body shape are encountering one situation: how to avoid their figure weakness and highlight the curvy figures. Even women with straight body shape which is one of the most flattering body types among runways need to improve their figure imperfections, especially in the summer. There's nothing better than wearing a linen cloth in the leaky days. Featuring in its absorbency, the linen fabric will keep you far away from the awful sticky feelings, allowing the skin to breathe freely. It is so absorbent that it will give the wearers exceptional coolness, freshness and comfort in the stiffing days. How can straight -shape linen dress properly this summer? Firstly, we need to have a better understanding of straight body shape.
The straight body shape, also known as H body shape and banana-shaped, is the most common types among American women. Probably women with straight body shapes are born for runways. The straight-shaped models are often seen in the runways. Typically, women with straight body shape have similar size of bust and hips. The bust and hips are balanced. The legs are slender and arms. Thus, they will be one of the best assets for this body shape. However, the waist will not be nicely defined. What's worse, the straight-shaped women may have flat bottom. It may be hard to create a curvy one. The waist-less type and flat bottoms will make women look boyish. When gaining weight, it probably falls to torso, upper thighs and arms. As a result, the key for women to dress properly is to proportionally wear the top and bottom of the body, enhance the waist and highlight the shapely legs.
A linen high waist linen shift dress will definitely make you curvy and "buxom". It is a perfect dress for women with straight body shapes. The high waist dress hits high on the narrowest part of waist, skims over the hips and booty without pulling and miraculously lands at the perfect length that actually works in their favor. The high waist design will not only can camouflage the tummy, but also add the volume of bust and hips. If necessary, a belt tied on the waist will highlight the waist line. It can help you get rid of paper men and build a curvy figure.


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The euro zone should prepare to fire its bazooka when Silvio Berlusconi quits as Italian prime minister. Germany and the European Central Bank have been right to keep Rome on tenterhooks so long as it had a delinquent government. But even a credible new government could need help to get its borrowing costs under control and prevent a debt spiral that could destroy the single currency.
The ECB has the capacity to solve the euro crisis by acting as a lender of last resort to financially challenged governments, as there is no limit to the euros it can print. But the central bank – as well as Germany, the zone's main paymaster – have resisted this for three reasons. First, they are worried about inflation. Second, direct financing of governments contravenes the Lisbon Treaty. Third, they feel bailing out irresponsible governments will encourage continued bad behaviour.
The first concern is misplaced: inflation may be 3 per cent but, over the medium term, the bigger risk is deflation. The second worry can be overcome by designing the bazooka in a way that doesn't run foul of the treaty. That left the so-called moral hazard as the only valid reason for inaction – or, rather, limited action given that the ECB has been buying some Italian bonds in the market since August.
Mr. Berlusconi has now said he will resign once key reforms have passed parliament. If Italy forms a new government that pushes through reforms to boost growth and brings down debt, its problems may be over. But don't count on it. Given Rome's loss of credibility in recent months, any post-Berlusconi market bounce could be short-lived.
The euro zone's current support mechanism – based on using elaborate financial engineering to leverage up the European Financial Stability Facility, the region's bail-out fund – is virtually dead. As a result, a real bazooka is needed. To get round the treaty's restrictions, the best way forward is probably for the ECB to lend to the EFSF to expand its firepower (or some variation on this scheme). The time for Germany and the ECB to hold their noses and back such an idea is fast approaching.


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MUSCLE (Multi User Server Client Linking Environment) is an N-way messaging server and networking API. It includes client-side networking APIs for various languages, including C, C++, C#, Delphi, Java, and Python. MUSCLE lets programs communicate over a network via streams of serialized Message objects. The included server program ("muscled") lets its clients message each other and store information in its server-side hierarchical database. The database supports flexible queries via hierarchical wildcarding, and "live" updates via a subscription mechanism.
Release Notes: This is a very minor release that adds some additional convenience methods to the String and Queue classes, adds some debugging support to the StorageReflectSession class, and fixes a crash bug in hexterm.
pys60 emulator is a simple and incomplete "Python for S60" emulator library. It's just enough for testing some simple example pys60 applications. It is still missing a lot of features.
Release Notes: This release adds e32db, appuifw.Listbox, and graphics.Image.
Ahcpd is an implementation of the Ad-Hoc Configuration Protocol (AHCP), a configuration protocol designed for networks where DHCP doesn't work, such as wireless mesh networks.
Release Notes: Ported to OpenBSD and Mac OS X.
ffDiaporama is an application for assembling photos and videos. It is especially suitable for preserving memories of holidays. It was inspired by presentation software such as Impress or Powerpoint. It can read all image formats, most camera and camcorder video formats, and the most commonly used music formats. It includes 140 transitions and a device database to enable the videos to be correctly rendered for more than 50 models of video viewing devices (including smartphones, tablets, and home cinema systems). ffDiaporama can manage several hundred slides. Each slide can contain tens of shots and tens of blocks, with each shot containing its own block settings. The application itself calculates all the shot transformations.
Release Notes: First beta version.
The OMPTL reimplements the algorithmic and numeric parts of the Standard Template Library of C++ to take advantage of parallel computing hardware such as Dual-Core and HyperThreading processors. The parallelization is done with the OpenMP API. The range of data is partitioned, and then the computation is executed in parallel.
Release Notes: An internal bug has been fixed.
Armitage is a graphical cyber attack management tool for Metasploit that visualizes your targets, recommends exploits, and exposes the advanced capabilities of the framework. Armitage aims to make Metasploit usable for security practitioners who understand hacking but don't use Metasploit every day. If you want to learn Metasploit and grow into the advanced features, Armitage can help you.
Release Notes: This release adds a smart payload configuration helper for client-side exploits. This allows users to use Metasploit 4's HTTP and HTTPS stagers through Armitage. This release fixes several bugs as well.
Dolibarr is a simple Web application with ERP and CRM capabilities. It is designed for small and medium companies, freelancers or foundations, and can be used to deal with all things you require to manage your activities, such as management of products, stocks, commercial proposals, invoices, orders, members of a foundation, and mailings. A single executable that installs the server and database is available for people with no technical knowledge.
Release Notes: Install this version only if you experience some problems with 3.0.0. A migration process will be presented; choose the last option, as in this version there is no database change compared to 3.0.0. 3.1.0 will soon be available as a beta.
bftpd is a very configurable Linux FTP server which can do chroot without special configuration or directory preparation. It will work out-of-the-box with almost no configuration required, and works on all Unix variants tested. Most FTP commands are supported, and user authentication is done via passwd/shadow or PAM. tar/gzip on-the-fly is supported.
Release Notes: This version includes a fix for dealing with named pipes. Previously performing a directory listing on a directory that included a named pipe would cause Bftpd's connect to stall. This release provides a work-around so that directory listings complete cleanly.
MIDI Sight Reader is an online music application (mupplet) inspired by its predecessor, the original MidiFlashCard system. The application scrolls both piano notes and guitar tablature. Notes are played for audio confirmation as they pass under the centerline on the window. The scrolling staffs drive a keyboard model and a guitar neck model. The guitar and keyboard can drive each other as well, for interactive exploration of the correspondence between the two instruments. The 3 components, staff, keyboard and guitar, can be independently added and removed from the top down, so many combinations of layout can be achieved.
Release Notes: This release fixes a bug where the bass clef key signature was being rendered one half space too low. All generated note structure capabilities (i.e. Single, Double, and Chord) are now fully implemented and can be toggled on/off individually.
MagicDraw is a visual UML modeling and CASE tool with teamwork support. It is designed for business analysts, software analysts, programmers, QA engineers, and documentation writers. This dynamic and versatile development tool facilitates analysis and design of Object Oriented (OO) systems and databases. It provides a code engineering mechanism (with full round-trip support for J2EE, C#, C++, CORBA IDL programming languages, .NET, XML Schema, WSDL), as well as database schema modeling, DDL generation, and reverse engineering facilities.
Release Notes: New features in this release include UML 2.4.1 support, Cameo Team Server integration, validation visualization in matrixes, a QVT plugin, a TOGAF plugin, a generic numbering mechanism in DSL models, and a converter to convert MagicDraw 9.x files to the latest format.
StepSim is a lightweight step-based simulation module written in Python. It can do simple real-time simulations of discrete systems. StepSim supports step-by-step simulation or can run until a break condition occurs. Simulations are made up of containers and converters. A container stores a discrete amount of units of a certain type. A converter draws units from one or more containers and delivers the result to another container. StepSim does not even attempt to do any parallel processing. It processes converters round-robin in a fixed order.
Release Notes: Stepsim is more deterministic now: milestone calculations will yield the same results for identical input, no matter what the order of contributing converters. The total completeness percentage calculation for milestones was fixed. A .dot graph can now be exported from milestone calculations.
MuseScore lets you notate and compose music easily with your keyboard, your mouse, or a MIDI keyboard. You can print beautifully engraved sheet music or export it as PDF or PNG. You can play your score, transpose it, and save it as audio or MIDI file. MuseScore also supports MusicXML to let you share your composition with other scorewriters. MuseScore is often advertised as a cost effective alternative for Sibelius and Finale.
Release Notes: A new jazz font was added. The creation of lead sheets was made much easier. The program now embeds a Twitter stream for the latest news and YouTube tutorial videos to learn about the software. It features sheet music shared by the MuseScore community, which can be downloaded for free. Last but not least, more than 60 bugs have been fixed and MuseScore is now translated into 43 languages.
Newscoop (formerly known as Campsite) is an open content management system for professional journalists. Features for the modern newsroom include multiple author management, issue-and-section based publishing, geolocation, and multilingual content management. The enterprise-standard journalist's dashboard and a templating engine supporting anything from HTML5 to mobile complete this fast production and publishing system.
Release Notes: The user experience in the user management screen was improved. The Zen theme was included into the new theme manager. User permissions were improved, "Select all" can be enabled to perform actions on permissions, the "Add Publication" button has been removed from the theme manager. Multiple bug fixes are also included from the last RC.
SOFA is a statistics, analysis, and reporting program with an emphasis on ease of use, learning as you go, and beautiful output. SOFA can connect directly to your database and lets you display results in an attractive format ready to share or put in a spreadsheet. SOFA will help you learn as you go, whether you are a student, business analyst, or researcher.
Release Notes: Data entry was made much easier and quicker. Importing of CSV files with lots of fields is now much faster. Feedback to the user was improved if a problem occurs in the early stages of starting SOFA. Lots of bugs were fixed.
Airtime lets you take total control of your radio station via the Web with intelligent archive management, powerful search, an easy playlist builder, a simple scheduling calendar, and rock-solid automated playout. Features include fades, cues, playlists, a programme calendar, Icecast, Shoutcast, and Soundcloud integration, DJ and station manager roles, JQuery widgets, Liquidsoap playout, and a record and rebroadcast functionality. Powerful media archive features 'watch' folders to allow stations to magically synchronize files, auto-import files, and has multiple directory support. Users can interact with it through any Web browser. It comes with an 'easy install' package.
Release Notes: New features include a new file storage system and human-readable file structure, magic file synchronization, auto-import, and multiple-directory support. Other improvements include graceful recovery from reboot, output to Shoutcast, a new "Program Manager" role, better frontend widgets, and one command Ubuntu installation.
MSR Tools is a source code evolution analysis tool. It consists of a framework for mining software repositories and tools for metric calculation, visualization, and defect prediction.
Release Notes: ROC evaluation was implemented for prediction models. Some additional statistics were added. Some changes were made for visualizations. Minor improvements were made to the predictor GUI. Bugs were fixed.
GroupOffice is a groupware suite that takes your office online, implementing online collaboration and CRM. It allows you to share projects, calendars, files and email online with co-workers and clients. It is easy to use and fully customizable. It also features synchronization with PDAs and Outlook.
Release Notes: Some important security and bug fixes were made in this release. Upgrading is highly recommended.
Candle App Platform is an XML-centric rich application development platform for both desktops and the Internet. It supports technologies like XSLT, XQuery, XML Scheme, XUpdate, XHTML, and SVG, and a new scripting language - Candle (Common ApplicatioN Development LanguagE).
Release Notes: Support for XPath, XSLT, and XQuery was unified. Unified pattern support was implemented, which can match BNF-like grammar and RELAXNG-like schema. The candle command line version has been ported to Linux. A simple Web server was added, which enables Candle to be used for server-side scripting.
GTK, which stands for the Gimp ToolKit, is a library for creating graphical user interfaces. It is designed to be small and efficient, but still flexible enough to allow the programmer freedom in the interfaces created. GTK provides some unique features over standard widget libraries.
Release Notes: The file chooser received a redesign with several improvements. Minor bugs were fixed. Translations were updated.
MALODOS helps you to scan, store, and easily retrieve all your personal documents. Its storage format is open and documented, so your document archive can remain accessible even without MALODOS. The documents themselves are stored as standard PDF files, while their metadata (such as title, tags, and description) are stored into a separate SQLite database in an open format. With MALODOS, you can also manage existing files in PDF, JPEG, TIFF, and other formats, so you can still use the documents that you've already scanned. You can connect to any external OCR program to give access to a fulltext search feature.
Release Notes: This release added virtual folders, a tag folder view, and documents to go.
KAlarm lets you schedule personal messages to display, audio files to play, commands to execute, or emails to send. Among its options, it allows you to choose the message font and color, recurrence schedule, whether to display an advance reminder, whether to speak the message or play a sound when it is displayed, and whether to cancel the alarm if it can't be triggered on time (e.g. if you are logged out at the time). As well as using the graphical interface to configure alarms, you can use the command line, and there is a D-Bus/DCOP interface for other applications.
Release Notes: This release fixes the Wake From Suspend dialogue not appearing or crashing. It also fixes handbook translations not being installed properly. It includes a new Dutch translation of the handbook.
Sympa is a scalable and highly customizable mailing list software. It can cope with big lists (780,000 subscribers), and it comes with a complete Web interface for both the user and the administrator. It is internationalized. Sites can customize Web and mail templates, authentication backends, and authorization scenarios. Dynamic mailing lists can use multiple backends (LDAP, SQL, files, lists, or others). Sympa is the only S/MIME and DKIM enabled mailing list software, and it provides both authentication and encryption.
Release Notes: Thie release includes bugfixes and improvmenets in the i18n catalogues.
Firewall Builder consists of a GUI and set of policy compilers for various firewall platforms. It helps users maintain a database of objects and allows policy editing using simple drag-and-drop operations. The GUI and policy compilers are completely independent, which provides for a consistent abstract model and the same GUI for different firewall platforms. It currently supports iptables, ipfilter, ipfw, OpenBSD pf, Cisco PIX and FWSM, and Cisco routers access lists.
Release Notes: This release includes multiple GUI enhancements and improved support for large configurations with new features like user defined subfolders, keywords for tagging objects, dynamic groups with smart filters, and more. Other new features include support for importing PF configuration files and a new object type called Attached Networks, which represents the list of networks connected to a network interface.
USL is an object-oriented scripting language written with C++ and compiled on both Linux and Windows. Without a script provided, USL is an interactive interpreter and programmable command shell. There is no socket programming with USL. USL is intended for general purpose scripting in local systems.
Release Notes: This release adds "user" and "machine" to the environment variables symbol.
DeforaOS Browser is a file browser for the DeforaOS desktop. It depends only on GTK+ 2 and the DeforaOS System and Desktop libraries. It supports browsing with multiple views, MIME type application association, and file manipulation. It also features a program to display file icons on the desktop, which is useful with window managers like WindowMaker or Fluxbox.
Release Notes: This version provides many fixes and improvements to the newly-introduced plug-in system, as well as the two original plug-ins. It also contains a new one, "CVS", greatly assisting while working on projects using CVS for source control management.
A class that merges XML documents from strings or DOM objects.
A tool that generates interactive HTML5 presentations containing editable code snippets.


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MOVIE SYNOPSIS [ General Audiences ] Film of Christian Genzel. Introduced in movie theaters in 2011, with a production coming from Germany and Austria. You can watch Die Muse online on TV cable or theaters with original audio in German at different dates. This film premiered in theaters in 2011.
Rating: 5 by 31 users./
Runtime: 95 minutes
Thomas Limpinsel, Henriette Müller, Jean-Luc Julien, Peter O. Kellerer, Lena Härtinger, Johanna Lohrum, Fynn Winkler, Martin Zech, Michael Zech and Hella Stichlmair.
95-minute film (full movie) directed by Christian Genzel.
The original audio of Die Muse has dialogues in or German, it was produced in Germany, Austria.
It premiered in cinemas or television in 2011.
Screenplay written by Christian Genzel.
Oliver Froeschke.
Georg Dehghan, Christian Genzel, Anja Dehghan, Mike Dehghan and Kristian Stern.
This film was produced and / or financed by High5Films and Ghost Light Productions.
Composed by Axel Tenner.
Without commercial breaks, the full movie Die Muse has a duration of 95 minutes; the official trailer can be watched in streaming on the Internet. You can watch this full movie free in English or German in movie TV channels, renting the DVD or with VoD services (Video On Demand player, Hulu) and PPV (Pay Per View, Netflix).
See the page of this full movie, Die Muse in FULLTV Movies.


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About Zymoclean™ Gel RNA Recovery Kit
The Zymoclean™ Gel RNA Recovery Kit provides a quick and efficient purification method for recovery of RNA fragments from agarose gels. The procedure combines a unique, single-step agarose dissolving/RNA binding buffer with Fast-Spin column technology to yield high quality, purified RNA in just minutes. The purified RNA is eluted into small volumes of DNase/RNase-free water for highly concentrated samples suitable for subsequent RNA-based manipulations. Compatible with MOPS, TAE, and TBE buffered agarose gels (formaldehyde up to 2.0%).
|Spin Column
|Processing Time
|30 min
|Sample Sources
|Single- or double-stranded RNA fragments (≥200 nucleotides) resolved in MOPS, TAE and TBE buffered agarose gels.
|RNA Purity
|High quality RNA (A260/A280 > 1.8, A260/A230 > 1.8) suitable for all downstream RNA-based manipulations.
|RNA Recovery
|The recovery rate for fragments ≥500 nucleotides is ≥80 %. Total binding capacity of the supplied Zymo-Spin IC™ Columns is ≤ 5 µg.
|RNA Storage
|RNA is eluted with RNase-free water and can be stored at ≤ -70°C. The addition of RNase inhibitors is optional but highly recommended for prolonged storage.
|Equipment Needed
|Microcentrifuge, 37 to 65ºC heat source.
The recovery of RNA from an agarose gel. Different sized RNAs on the left were excised from the gel and recovered using the Zymoclean™ Gel RNA Recovery Kit (lanes 1-4)
|Step 1
Excise the RNA fragment from the agarose1 gel using a razor blade or scalpel and transfer it to a 1.5 ml microcentrifuge tube.
|Step 2
Add 3 volumes of RAD Buffer™ to each volume of agarose excised from the gel.
|Step 3
Incubate2 at 37-55°C for 5-10 minutes or until the gel slice is completely dissolved.
|Step 4
Transfer the mixture to Zymo-Spin™ IC Column in a Collection Tube.
|Step 5
Centrifuge at ≥12,000 x g for 2 minutes. Discard the flow-through.
|Step 6
Add 400 µl RNA Prep Buffer to the column. Centrifuge at ≥12,000 x g for 1 minute. Discard the flow-through and replace the Zymo-Spin™ IC Column back into the Collection Tube.
|Step 7
Add 800 µl RNA Wash Buffer to the column. Centrifuge at ≥12,000 x g for 30 seconds. Discard the flow-through and replace the Zymo-Spin™ IC Column back into the Collection Tube. Repeat the wash step with 400 µl RNA Wash Buffer
|Step 8
Centrifuge the Zymo-Spin™ IC Column at ≥12,000 x g for 2 minutes in the emptied Collection Tube to ensure complete removal of the wash buffer.
|Step 9
Carefully remove the Zymo-Spin™ IC Column from the Collection Tube and place into a DNase/RNase-Free Tube. Add ≥6 µl DNase/RNase-Free Water3 directly to the column matrix and let stand for 1 minute.
|Step 10
Centrifuge at 10,000 × g for 30 seconds to elute the RNA from the column. RNA can be used immediately or stored at ≤-70 oC (see Specifications, page 1).
"I did a direct comparison with the Qiagen kit (which we normally use) on duplicate samples. I found the yields to be the same, but the high concentration from Zymo resulting from the low elution volume was extremely helpful for a downstream ligation. That ligation also showed that the DNA products from both kits performed exactly the same (within the resolution of a standard gel). The elution concentration is probably the best aspect. The reduced number of buffers and steps is also nice, as are the low-bind column containers. I'll probably be using this kit from now on."
Adam C. (University of Texas, Southwestern)
"I had tried three other kits to do a certain recovery before this, I was getting bad yields, the elution volume required was quite large, the protocols were not as easy to follow and they took longer to complete. I liked everything about this kit, it is simple, efficient and quick. The protocol is easy to follow and the yield was 4-5 times better than what I got from other kits."
Wendy P. (University of Auckland)
"It's a kit with a faster protocol and [has] a very good efficiency in quantity of DNA recovered. Also have a possibility to elute only in 6 µl of water. "
Joao B, (Instituto de Tecnologia Química e Biológica)
"Protocols are very well written and Instructions easy to follow. Always had good results with your products."
Simin H. (University of California, Irvine)
"The kit was very easy to follow and yielded good results. It was more affordable than the Qiagen Gel Extraction kits, but worked just as efficiently. Solid product"
Thomas B (University of Tennessee, Knoxville)
"The ADB buffer and higher temperature used melted the gel quicker than previously used kits thus making DNA recovery using this kit more efficient and generally quicker than previously used kits."
Kelly-Anne F.
"The best advantage about this kit is that it is really quick to make it, and the total DNA recuperated have a good quality and it have a good concentration to follow the experiments."
Ingrid M.


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God lives in Belgium and he's not very nice.
In Jaco Van Dormael's clever, redemptive satire "The Brand New Testament" God wears a bathrobe, drinks beer, pecks at a computer and takes devilish delight in irritating his creations. His 10-year-old daughter is fed up with his antics and calamities. She runs away from their strange heaven to gather her own disciples and write new gospels to heal the world's wounded souls. Her brother, JC, who most of the time is a statue on a shelf, hops down for a moment and gives his blessing.
"The Brand New Testament" rearranges notions of faith with a secularist's vision that good dwells in all of us and happiness doesn't require dogma. It is a modern fable about finding refuge amid the clamor and drawing meaning from one another in a world that is at once neurotic and aloof to the hushed and often sublime music playing through our lives.
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God's daughter, Ea, escapes to Earth through a washing machine to gather six new disciples, a melancholic, despairing bunch that includes Martine (played by Catherine Deneuve), a rich, neglected wife who takes a gorilla as a lover. The disciples' encounters with Ea lift their veils of isolation and they find new loves, ambitions and a sense that life, as fleeting as it is, can be divine and resonate in shared humanity.
The film toys with creation myths and echoes with European absurdist sensibilities; it is as irreverent as it is inviting, and imagines a world where God, a tyrant, is replaced by his daughter and his wife, a whimsical woman who roams heaven (a disheveled apartment) in a housecoat. His wife takes over the computer and summons her vision of the planet: a sky woven with embroidery, a place where people bloom into who they are without fear of reprisal or judgment.
"The Brand New Testament" has been nominated for a Golden Globe and has been shortlisted for an Academy Award nomination for best foreign-language film. A husky man with a graying beard and a playful, expectant gaze, Van Dormael, whose other films include "Mr. Nobody" starring Jared Leto, has been showing his movie this week at the Palm Springs International Film Festival, which ends on Monday.
This is an edited conversation with Van Dormael about life, Alice in Wonderland and a Spaniard inside a gorilla costume.
What are you saying about God in this film?
I don't believe in God, so for me it's more like a fairy tale. I take the story line of the Bible and the New Testament, but I don't think it's about religion or even God. But in religion there is this absence of women and power of men. The film is more about society and family. It's about domination that you have to obey. It's about fear, punishment. But what the little girl brings is that you don't have to be afraid.
God's daughter and wife offer an alternative to the paternalistic designs that have shaped religion, arts and so much else.
I had a Catholic education as a kid and I was surprised that no women said anything. But in my family my mother was speaking a lot and [now] my daughters are speaking a lot too. They're rebels. That was the beginning of the story: What if ... ?
God becomes irrelevant in the film once people are reminded of their mortality by receiving text messages giving the exact dates of their deaths. That's a sobering revelation. What does that suggest about religion and our time on this Earth?
People remember they're mortals. I think religion can give strength to some people. Myself, I find I'm more strong with doubts. I love doubting. The questions are more interesting than the answers. I love to make films that ask questions but don't give answers. There's a saying that religion and film have one thing in common: Both try to make you believe that life could have meaning. But even if it doesn't have meaning, this being alive is a great experiment.
There's a whimsical quality to the "new" gospels as the daughter seeks her disciples. What were you trying to create here?
It's a sort of exotic structure like Alice in Wonderland or Don Quixote. You're not waiting for the end of the story to understand. You're in the middle of the path smelling the grass.
Each of the daughter's disciples is damaged in some way: physical, emotional, psychological. What did these characters represent?
We were looking for magnificent losers. That life is not for them anymore. They will not be happy. There's a sentence in there that says if happiness was a house the biggest room would be the waiting room. They've spent all their lives in the waiting room. The human brain can put us into little prisons that say my life is nothing else. But [Ea] opens a little box and says you can be anything you want. You have a life and a love that's not in the catalog of the usual. It's about strange couples. They don't fit but that have beautiful love stories.
The most provocative gospel story features Catherine Deneuve's love affair with a gorilla. Her life is so devoid of joy that she finds it in the most unexpected place. Was it fun to play with this idea?
Yes, it's a strange story. She finds the gorilla more protective than her husband. She [Deneuve] was totally open to it. She's a fantastic actress. There was a Spanish guy in the gorilla suit and two other Spanish guys were moving the face with a little motor. She was laughing all the time. She was saved by a gorilla.
Has the film drawn any criticism from churches or organized religion?
I was really surprised. In Belgium and Switzerland, the websites of the church said they propose that people go and see the film because it's interesting and [followers] could discuss the place of the women in the church. The miracle of God's daughter is, I can make you dream. I can make you fall in love. All those little things that make us feel alive.
Twitter: @JeffreyLAT


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Use mouse to play,zombie will automatically move forward,player need to click need to click on various machinerys and traps in time to help zombie avoid obstacles and dangers,click zombie to stop him,click again to continue to move,the goal of each level
Zombie Warrior Man wants revenge on his captors and the evil doctor that made him this way! You are the Zombie Warrior Man that looks like Iron Maiden Eddie equipped with a chainsaw. Make your way in this bloody splatter game! Use arrow keys to move; Spac
Zombie Warrior is held captive in the hospital while they perform experiments on him. Zombie Warrior however does not much like hospitals as they make him mad. Help him to escape and teach his captors not to mess with zombies. Use arrow keys to move; Spac
Lala Zombie is an interesting dress-up game for free. LaLa is a pretty zombie girl. Her hobby is fashion. She is very friendly zombie. So, today she is going to the fashion party. Help her choose some new clothes and dress up. Have fun!


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Key ISIS fighter from Birmingham BLOWN TO PIECES after being hit by US drone strike
A TOP BRITISH Islamic State hacker has been killed after being targeted by a US drone strike.
Junaid Hussain, 21, was blown away as he drove in a vehicle towards the Syrian city of Raqqa – ISIS' self-declared capital.
Hussain critical to ISIS recruitment and online operations.
"We have a high level of confidence he was killed," a US official said.
"There is a good deal of sensitivity because Hussain was a British citizen targeted by the US."
Hussain, from Birmingham, was married to Kent housewife turned jihadi bride Sally Jones and fled Britain to travel to Syria in 2013.
Earlier this month Jones – known as Mrs Terror – boasted of lone wolf terrorists being ready to strike the UK.
Jones, from Buckinghamshire, has denied claims her jihadi husband is dead.
She told another jihadi bride she is "blessed her husband is still alive".
Reports have described Hussain as a key operative in the extremist group, allegedly involved in online hacking and recruitment activities.
The 21-year-old was said last month to have been number three on the Pentagon's "kill list" of IS targets.
"We have a high level of confidence he was killed"A US source
Hussain is thought to have fled Britain to travel to Syria in 2013.
In June this year, he was linked with an IS plot to attack an Armed Forces Day parade in south London.
It was reported that the plan to explode a pressure cooker bomb - killing soldiers and bystanders on the route - failed after one Hussain unwittingly recruited an undercover investigator from The Sun to carry it out.
He allegedly told the investigator: "It will be big. We will hit the kuffar (unbelievers) hard InshAllah. Hit their soldiers in their own land. InshAllah.
"Soldiers that served in Iraq and Afganistan will be present. Jump in the crowd and detonate the bomb.
"They think they can kill Muslims in Iraq and Afghanistan then come back to the UK and be safe. We'll hit them hard InshAllah."
In June 2012, aged 18, Hussain was jailed for six months after making prank calls to a counter-terror hotline.
He admitted making the nuisance calls and publishing former prime minister Tony Blair's address book in June the previous year.
Hussain was a member of TeaMpOisoN (TeamPoison), a group which had claimed responsibility for more than 1,400 offences where personal and private information has been illegally extracted from victims in the UK and around the world.
TeamPoison also claimed to be behind online hacking attacks involving foreign politicians, major international businesses, an international humanitarian agency and foreign law enforcement.


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World War II. 18.1 The Outbreak of World War II. Nazi Expansion. March 1939 – Hitler's armies occupied all of Czechoslovakia Hitler wants Polish city of Danzig = defies Munich Agreement Poles refuse to surrender city. Nazi Expansion. France & Britain
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
18.1 The Outbreak of World War II
German U-Boats –
Continued to cause serious damage to Allied ships & supplies
Allies counteracted with –
Better sonar
Faster escort ships
Bombing of submarine shipyards
Nazis lost 783 U-Boats


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IRCON ISL Recruitment 2016 Advertisement has published recently. IRCON Infrastructure Service Limited has released a recruitment notification for 26 Work Engineer, Project Engineer, Assistant Project Engineer Posts. Excellent news for candidates who are preparing for the Government Jobs in India. All Eligible and Interested candidates can apply for IRCON Recruitment 2016 through Offline Mode on or before the last date 26th November 2016. Candidates, those who are looking for newly upcoming Latest Government Jobs updates can visit our website www.wingovtjobs.com; we provide all Government Jobs like Central Government Jobs, State Government Jobs, Teacher Jobs, etc.
- 1 IRCON ISL Recruitment 2016 for 26 Civil Engineer Vacancies
- 1.1 IRCON Civil Engineer Job Vacancy Details
- 1.2 IRCON ISL Recruitment 2016 – Overview
- 1.3 Eligibility Criteria for IRCON Civil Engineer Jobs
- 1.4 Important Dates for IRCON ISL Civil Engineer Recruitment 2016
- 1.5 Procedure for Applying IRCON ISL Civil Engineer Vacancies
IRCON ISL Recruitment 2016 for 26 Civil Engineer Vacancies
IRCON Infrastructure Service Limited is a wholly owned subsidiary of Ircon International Limited, which is a government company under the Ministry of Railways engaged in providing the Project Management, Quality Management, Safety and health and environment related consultancy services and other business support and related services to clients in India and abroad. Interested candidates can check the eligibility details before applying for IRCON Recruitment. All the details of Eligibility Criteria like Education Qualification, Age Limit, Selection Process, How To Apply, etc. are given below. For more information regarding the IRCON ISL Recruitment 2016, candidates can visit Official Website www.irconisl.com.
IRCON Civil Engineer Job Vacancy Details
Name of the Post: Civil Engineer.
Number of Vacancies: 26 Posts.
Post Wise Vacancy Details
|Post Name
|Number of Vacancies
|Project Engineer
|06 Posts
|Project Assistant Engineer
|10 Posts
|Work Engineer
|10 Posts
IRCON ISL Recruitment 2016 – Overview
Name of the Organization: IRCON Infrastructure and Service Limited.
Name of the Post: Civil Engineering.
Number of Vacancies: 26 Posts.
Apply Mode: Offline.
Job Location: New Delhi.
Job Category: Central Government Job.
Official Website: www.irconisl.com.
Selection Process: Candidates will be selected based on the performance in following rounds
- Written Test
- Personal Interview.
Pay Scale:
Post Wise Salary Details
- Project Engineer: USD 2250/- pm.
- Assistant Project Engineer: USD 1150/- pm.
- Work Engineer: USD 900/- pm.
Eligibility Criteria for IRCON Civil Engineer Jobs
Applying candidates can check the eligibility details like Education Qualification and Age Limit details here.
Education Qualification for IRCON ISL Civil Engineer Posts.
Applying candidates should possess Degree in Civil Engineering with minimum 60% marks.
Age Limit for IRCON ISL Recruitment
Minimum Age Limit: 21 years.
Post Wise Maximum Age Limit
- Project Engineer: 45 years.
- Assistant Project Engineer: 35 years.
- Work Engineer: 30 years.
Important Dates for IRCON ISL Civil Engineer Recruitment 2016
- Online Application Commencement from: Available now.
- Last Date for Submitting Online Application: 26th November 2016.
Post-Wise Interview Dates
- Project Engineer: 06th December 2016 at 10 AM.
- Assistant Project Engineer: 07th December 2016 at 10 AM.
- Work Engineer: 08th December 2016 at 10 AM.
Procedure for Applying IRCON ISL Civil Engineer Vacancies
- Candidates log on to the IRCON Official Website www.irconisl.com.
- Click on the advertisement of IRCON Civil Engineer Job link.
- Next, Download the Application form.
- Read the instructions thoroughly to know the eligibility details.
- Fill all the details in the IRCON ISL application form.
- Attach all the required copies of documents.
- Finally, Send to the authorities.
Postal Address
The Chief Executive Officer,
IRCON Infrastructure and Service and Limited,
C-4, District Centre,
Saket, New Delhi – 110017.
Click Here to Download the IRCON Civil Engineer Official Notification 2016
Please contact for winGovt jobs job updates through WhatsApp first save this number as wingovtjobs and ask queries alerts +917842332266.
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FREMONT, Calif., July 17, 2017 /PRNewswire/ -- Asterias Biotherapeutics, Inc. (NYSE MKT: AST), a biotechnology company pioneering the field of regenerative medicine, today announced completion of enrollment and dosing of the AIS-A 20 million cell cohort in the company's ongoing SCiStar Phase 1/2a clinical study of AST-OPC1 in complete cervical spinal cord injury (SCI). In this cohort, five patients with AIS-A grade SCIs were administered 20 million AST-OPC1 cells. The 20 million AST-OPC1 cell dose is the highest to be investigated in the SCiStar Phase 1/2a clinical trial. The company expects to report top-line six-month results from this cohort in January 2018.
"Completing enrollment and dosing of the first cohort of patients receiving 20 million AST-OPC1 cells marks another important milestone for our SCiStar study," said Dr. Edward Wirth, Chief Medical Officer of Asterias. "The results from this cohort will help us evaluate what is the optimal dose for a future, larger clinical study. We look forward to evaluating the data from our enrolled cohorts as we begin to design the next study for AST-OPC1."
Enrolling and dosing the fifth patient in this cohort triggers the final $1.5 million grant payment from the California Institute for Regenerative Medicine (CIRM) under the existing $14.3 million Strategic Partnerships Award grant awarded to Asterias. Asterias expects to receive this grant payment in the third quarter of 2017.
"On behalf of Asterias, its employees and the spinal cord injury community, I'd like to thank CIRM for its support of AST-OPC1 and the SCiStar study," stated Mike Mulroy, President and CEO of Asterias. "We look forward to continuing our relationship with CIRM as we advance this important program."
Asterias has now completed enrollment and dosing in four of the five planned SCiStar study cohorts and enrolled twenty patients in the SCiStar study. Twenty-five patients have been administered AST-OPC1 after including patients from a previous Phase 1 safety trial and results-to-date continue to support the safety of AST-OPC1, with no serious adverse events related to AST-OPC1 or its administration. In June 2017, Asterias reported 9 month data from the AIS-A 10 million cell cohort that showed improvements in arm, hand and finger function observed at 3-months and 6-months following administration of AST-OPC1 were confirmed and in some patients further increased at 9-months. The company intends to complete enrollment of the entire SCiStar study later this year, with multiple safety and efficacy readouts anticipated during the remainder of 2017 and 2018.
About the SCiStar Trial
The SCiStar trial is an open-label, single-arm trial testing three sequential escalating doses of AST-OPC1 administered at up to 20 million AST-OPC1 cells in as many as 35 patients with subacute, C-4 to C-7, motor complete (AIS-A or AIS-B) cervical SCI. These individuals have essentially lost all movement below their injury site and experience severe paralysis of the upper and lower limbs. AIS-A patients have lost all motor and sensory function below their injury site, while AIS-B patients have lost all motor function but may have retained some minimal sensory function below their injury site. AST-OPC1 is being administered 21 to 42 days post-injury. Patients will be followed by neurological exams and imaging procedures to assess the safety and activity of the product.
The study is being conducted at six centers in the U.S. and the company plans to increase this to up to 12 sites to accommodate the expanded patient enrollment. Clinical sites involved in the study include the Medical College of Wisconsin in Milwaukee, Shepherd Medical Center in Atlanta, University of Southern California (USC) jointly with Rancho Los Amigos National Rehabilitation Center in Los Angeles, Indiana University, Rush University Medical Center in Chicago and Santa Clara Valley Medical Center in San Jose jointly with Stanford University.
Asterias has received a Strategic Partnerships Award grant from the California Institute for Regenerative Medicine, which provides $14.3 million of non-dilutive funding for the Phase 1/2a clinical trial and other product development activities for AST-OPC1.
Additional information on the Phase 1/2a trial, including trial sites, can be found at www.clinicaltrials.gov, using Identifier NCT02302157, and at the SCiStar Study Website (www.SCiStar-study.com).
About AST-OPC1
AST-OPC1, an oligodendrocyte progenitor population derived from human embryonic stem cells originally isolated in 1998, has been shown in animals and in vitro to have three potentially reparative functions that address the complex pathologies observed at the injury site of a spinal cord injury. These activities of AST-OPC1 include production of neurotrophic factors, stimulation of vascularization, and induction of remyelination of denuded axons, all of which are critical for survival, regrowth and conduction of nerve impulses through axons at the injury site. In preclinical animal testing, AST-OPC1 administration led to remyelination of axons, improved hindlimb and forelimb locomotor function, dramatic reductions in injury-related cavitation and significant preservation of myelinated axons traversing the injury site.
In a previous Phase 1 clinical trial, five patients with neurologically complete, thoracic spinal cord injury were administered two million AST-OPC1 cells at the spinal cord injury site 7-14 days post-injury. Based on the results of this study, Asterias received clearance from FDA to progress testing of AST-OPC1 to patients with cervical spine injuries in the current SCiStar study, which represents the first targeted population for registration trials. Asterias has completed enrollment in the first four cohorts of this study. Results to date have continued to support the safety of AST-OPC1, with no serious adverse events related to AST-OPC1 or its administration. Additionally, Asterias has recently reported results suggesting reduced cavitation and improved motor function in patients administered AST-OPC1 in the SCiStar trial.
About Asterias Biotherapeutics
Asterias Biotherapeutics, Inc. is a biotechnology company pioneering the field of regenerative medicine. The company's proprietary cell therapy programs are based on its pluripotent stem cell and immunotherapy platform technologies. Asterias is presently focused on advancing three clinical-stage programs which have the potential to address areas of very high unmet medical need in the fields of neurology and oncology. AST-OPC1 (oligodendrocyte progenitor cells) is currently in a Phase 1/2a dose escalation clinical trial in spinal cord injury. AST-VAC1 (antigen-presenting autologous dendritic cells) is undergoing continuing development by Asterias based on promising efficacy and safety data from a Phase 2 study in Acute Myeloid Leukemia (AML), with current efforts focused on streamlining and modernizing the manufacturing process. AST-VAC2 (antigen-presenting allogeneic dendritic cells) represents a second generation, allogeneic cancer immunotherapy. The company's research partner, Cancer Research UK, plans to begin a Phase 1/2a clinical trial of AST-VAC2 in non-small cell lung cancer in 2017. Additional information about Asterias can be found at www.asteriasbiotherapeutics.com.
Statements pertaining to future financial and/or operating and/or clinical research results, future growth in research, technology, clinical development, and potential opportunities for Asterias, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "believes," "plans," "anticipates," "expects," "estimates") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the businesses of Asterias, particularly those mentioned in the cautionary statements found in Asterias' filings with the Securities and Exchange Commission. Asterias disclaims any intent or obligation to update these forward-looking statements.
View original content:http://www.prnewswire.com/news-releases/asterias-biotherapeutics-completes-enrollment-and-dosing-of-scistar-studys-ais-a-20-million-cell-cohort-300488870.html
SOURCE Asterias Biotherapeutics, Inc.


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A multi-threaded server application designed to connect a network of Recognition Systems Biometric Hand Geometry Readers to an already existing time and attendance or security system running on virtually any platform including: AS/400, RS-6000, Oracle, NT and more. Real time data collection, error reporting, time synch., scheduled data export and much more are all standard features of HandLink.
Info updated on:


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23-year-old Frankfurt-based Romanian film photographer Oana Fuicu has been shooting for over 8 years and joined with us in few film photography projects before.
Oana loves to travel and take photos around as the best way to keep her lovely moments. She sometimes also shoots herself and has some analogue photos that she shot with her film cameras would like to share with us.
See more of her work at:
Monday, October 12, 2015
Oana Fuicu - Me and my film cameras
Posted by Pankha Nguyen
Labels: Me and my film cameras , Oana Fuicu , Portrait , Self-portrait
1 comment :
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A strappy pair of wedges is an exceptional wedding day shoe that isn't just fashionable, it's also functional . The elegant upper, combined with the rope detail on the wedge, creates a sophisticated but casual look.
- High wedge sandal
- Suede upper
- Rope wedge
- Heel height is approximately 3 5/8"
With every pair of shoe you purchase, TOMS will give a new pair of shoes to a child in need. One for One®.
Shown: Natural, 000000000010005782
TOMS run true to size and are available in medium width only. We recommend ordering the size you normally wear. If you are typically in between sizes, we recommend going with the smaller one since TOMS will stretch slightly as you break them in.


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From regal campuses to touted alumni, many boarding schools exude prestige.
We recently published a list of the most elite boarding schools in the US.
To come up with this list, we examined each school's endowment, acceptance rate, and average SAT score. We used data from BoardingSchoolReview.com . Data that was unavailable on BoardingSchoolReview.com was taken from the schools' websites or from Niche.
You can see the full list of schools here, and check out the top 25 below:
Skye Gould/Business Insider


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Godrej Authorised Service Provider
We are an autorised service provider for godrej furniture division.
We undertake maintenance, repaire and service for all kinds of godrej home, office, hospital, health care and laboratory furnitures.
Godrej Chair,Almirah,storwel,wardrobe,slimline,office table, office chairs,filing cabinet,glass door storwel,Book case,ofice counter and all other interio products of godrej.
Recaning,lock repairing,Re painting,Re Up holstery, fabric Shampooing and assembling of all kinds of furnitures.
Available all kinds of spares and accessories.


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Nagalla Bushview, Blackheath
House, Blackheath
Rated 4.5 out of 5 stars 12 reviews
Confirmation within 24hr
From $179 per night {{quote.pricing.message}} Total {{quote.pricing.price | format:'currency':'short'}} for
Min 1 night stay
Nagalla is a 2 bedroom cottage in a delightful area.
It is 5 minutes walk to the start of Pope's Glen walk out to Govett's Leap, and a 5 minute drive into Blackheath township for coffee shops, antiques , restaurants and bookshops etc.
The slow combustion fire warms up the whole house quickly . Wood is supplied.
It has a balcony overlooking the Bush, and a semi -covered verandah in the back with a bbq, table and chairs.
The master bedroom has fitted wardrobe and queen size bed with electric blanket.
The 2nd bedroom has bunk beds ,hence sleeps 2 people
A sunroom out the front has a spare bed, and can be used as a 3rd bedroom if required, or simply as another room to look out at the view and relax.
The stereo has a lead to plug into your MP3 player.
There are a few DVDs if you want to watch them.
The TV is a 40cms flat screen that will take your USBs if you wish ,in addition to free- to- air TV.
The garage is under the house, see photoIt has a roller door that is activated in the garage itself.
The house is on a steep drive, so it is not very suitable for people who are less physically able .
Nagalla is rustic,peaceful and comfortable.
I hope my guests will be as relaxed and happy there as I have been.
Information for your security,- this property is solely managed in Australia. No money will be requested from any overseas source.
Rating snapshot
Average customer ratings
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Have a question?
Feel free to send a message to the owner/manager if you have any specific needs, or if you require additional information before you can commit to a booking request.
Select request booking to access the quote calculator and to check availability.
Enter your check in and check out dates to see availability and a total price.
|Sun to Thurs ($ p/n avg.)
|Fri & Sat night
|7 night stay
|Min night stay
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|Extra child ($ p/n)
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The following dates have a special rate or exception applied. Please note any discounts applicable to these dates will still apply.
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|Yes No
p/n = per night, p/s = per stay, p/p = per person, p/np = per night and person. Ask the owner to arrange optional extras
Note: Pricing is subject to change, and a minimum stay period and other conditions may apply. You should confirm pricing with the property owner.
Prices listed based on 4 adults. Property has 4 beds and can sleep a maximum 4 people.
- Available
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- Description
The Makita FS6300 Drywall Screwdriver is fitted with a silent synchronized pin clutch for quiet operation and a lightweight aluminium gear housings for durability. It has a variable speed trigger with forward/reverse rotation for more control when in use.
The quick release locator removal for high holding strength for applications and lock on trigger facility to assist the user in high speed applications. Other features include a rubberised soft-grip, strong metal belt clip, a job light and double insulation.
It is supplied with a magnetic socket bit.
Bit Holder: 1/4in Hex.
Input Power: 570 Watt.
No Load Speed: 0-6,000/min.
Torque Settings S/H: 6/11Nm.
Capacity: Drywall Screw: 4mm.
Weight: 1.4kg.
Vibration K Factor: 1.5 m/sec.
Vibration No Load : 2.5 m/sec.
Noise Sound Power: 93 dB(A).
Noise Sound Pressure: 82 dB(A).
Noise K Factor: 3 dB(A).
- Additional Information
Additional Information
Condition New SKU PTDMAKFS6300L Weight (Kg) 2.1800 Brand Makita Manufacturers Part Number FS6300/1 Retailer Barcode 0088381600934 Package Height (cm) 31 Package Width (cm) 27 Package Length (cm) 7.5 Bullet 1 Proven reliable Makita technology Bullet 2 Lightweight construction at just 2.18 Kgs Bullet 3 High performace for the home or tradesman Bullet 4 No Bullet 5 No Bullet 6 No
- Reviews


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