text:
Stiff neck could sideline Lee for Sunday
Stiff neck could sideline Lee for Sunday
BOSTON -- Cliff Lee has been a pain in the neck to opposing batters all season. Now a pain in his own neck might keep him from making Sunday's start in Chicago. Lee's status for Sunday was already up in the air, as the Indians are considering sitting him if the White Sox's playoff fate is determined by that regular-season finale. And now that Lee -- the likely American League Cy Young Award winner -- is dealing with a stiff neck, his chances of making the start are lessened even further. Manager Eric Wedge didn't make Lee's neck condition out to be serious, describing it only as "a little stiff." But the Indians, obviously, wouldn't have much incentive to push Lee, who didn't throw his regularly scheduled bullpen session on Thursday.
"He got treatment on it [on Wednesday]," Wedge said. "We'll see how he feels [on Friday]." Lee's stuff has lacked some of its luster his last three outings, in which he's gone 1-1 with a 5.06 ERA. The loss on Tuesday night at Fenway Park was his first since July 6. If Lee (22-3, 2.54 ERA) does make his 32nd and final start on Sunday, he'll have a third opportunity to become the Majors' first 23-game winner since Barry Zito and Randy Johnson in 2002, as well as the chance to tie Vean Gregg's record for wins by a left-hander, set in 1911. Lee has had two other shots at those honors, and they resulted in a no-decision against the Twins and the loss to the Red Sox. Before the neck stiffness was divulged by Wedge, Lee said that he would like to make Sunday's start. "It's not my decision," Lee said. "My job is to pitch when they want me to pitch, and that's what I'll do. I definitely want to pitch every chance I get."
Anthony Castrovince is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


text:
Painstaking probe leads to arrest of driver in hit-and-run that may leave teen disabled
Sixteen-year-old Devaughn Moore was making his way home after filling out a job application to work in a coffee shop at Erie County Medical Center when a car struck him on Main Street in the Parkside neighborhood.
The driver sped away, leaving Devaughn crumpled on the road with a critical head injury. Tuesday, nearly five weeks later, he was released from Women & Children's Hospital and is now learning how to walk again.
Wednesday, Buffalo city accident investigators arrested Kevin A. Ford, a 23-year-old city garbage collector on disability, and charged him with leaving the scene of a serious physical injury accident and falsely reporting the car involved in the accident as having been stolen.
The car, which belongs to Ford's fiancée, Amherst resident Taylor Brown, was driven to a field off Ninth Street in Niagara Falls and set on fire hours after the hit-and-run accident on the night of Feb. 3, police said.
When Niagara Falls police responded to the car fire, it was not known that the vehicle was being sought in the accident, which occurred shortly after 7:30 p.m. on Main near Morris Avenue.
It would take an extensive investigation by three police agencies before Ford was confronted with the evidence and tearfully confessed that he was the driver who had fled after striking the Lafayette High School student as he walked across Main.
The key piece of evidence was the shell of a shattered gray rear-view mirror recovered from the scene, according to Lt. Thomas J. Leatherbarrow, commander of the city's Accident Investigation Unit.
Senior Accident Investigator Martin Forero and Accident Investigators Keith S. LaFalce and Santos V. Diaz sought assistance from Amherst Senior Accident Investigator Scott A. Lawida, who is regarded as an area expert in broken auto parts recovered from hit-and-run accident scenes.
Lawida determined that the mirror was from the passenger side of a 2006 Chevy Impala. Police then searched the state Department of Motor Vehicles' computer database and came up with more than 500 cars that fit that description in Erie County.
The accident investigators then set to work visiting the addresses of where the cars were registered, each time inspecting the vehicles for damage and a replacement side view mirror.
"We went door to door throughout the county inspecting cars for damage," Forero said Thursday. "It was a process of elimination."
Amherst Senior Accident Investigator Bob McMahon caught a break when he and LaFalce were heading over to an address on the 100 block of Princeton Avenue in the town and near the Buffalo border. McMahon ran a license plate check on the vehicle and a report came back that it had been reported stolen the same night as the accident.
Ford had told city police at the Central District Station downtown that his fiancée's car had been stolen.
When McMahon and LaFalce arrived at the Princeton Avenue address, they spoke with Brown, who informed them that Ford usually drove the car.
The investigation was now hitting high gear. Police learned that on the night of the crash, Ford was scheduled to attend psychology classes at D'Youville College on the city's West Side. The torched car was located at an insurance impound yard and it was determined that not only was the passenger side rear-view mirror missing, but that there was damage to the right front fender.
With evidence pointing to Ford, LaFalce and Diaz went to his home on Princeton and brought him to Buffalo Police Headquarters for questioning, according to police.
As the interview progressed, Ford, who also claimed to have a Buffalo residence, confessed that he was the driver and began sobbing uncontrollably, police said.
The investigation is not over. Charges of insurance fraud for filing a false claim of a stolen car and arson also are being considered.
In addition to Buffalo and Amherst accident investigators, Niagara Falls Detective Bill Smith and Erie County District Attorney investigators supervised by Assistant District Attorney Kelley Omel are continuing the probe.
Also, Jed Dietrich, the attorney representing Devaughn, pointed out that under state law, Ford's fiancée could face penalties because she owns the vehicle.
"Devaughn's family wants to personally express their gratitude to all of the police agencies that diligently investigated and brought this matter to this stage," Dietrich said.
Devaughn's mother, Rasheena Sturgis, said her son had gone to the Tim Hortons coffee shop in the lobby of ECMC to apply for a job and was on his way home when the accident occurred.
"He's very independent and wanted his own money and he wanted to help me because I'm a single parent," Sturgis said.
Now her son faces a long road in rebuilding his independence. Sturgis also said she is grateful to the medical staff who treated her son at Women & Childrens Hospital.
How long her son's physical rehabilitation will take, Sturgis said, is unknown. "He's still working on learning how to walk," she said.
Ford is scheduled to appear in Buffalo City Court on Thursday.
email: firstname.lastname@example.com

subset: commoncrawl


text:
Price is $3000, but I am negotiable. Shoot me a decent offer and it's yours.
So I'm ready to sell this van. A lot of this post will be copied from Craigslist. It's got a 1998 GTP engine, 4t65e-hd trans, axles, diff, etc. I did not do the swap, it was done by an auto electric mechanic also in Florida. Me and my father did do the intercooler and other aftermarket stuff all about 4500 miles ago, and it hasn't given me a problem since.
Here's the list of performance stuff that has been put on:
ZZP Stage 2 water to air intercooler.
ZZP Ported and machined lower intake manifold
ZZP Powdercoated modified fuel rails
ZZP 3.2" Modular Pulley
K&N filter, 4" intake
PCM tuned by Intense Racing
2.5" exhaust from manifold back
Aeroforce scangauge
Drilled and slotted front rotors
All of that was done in the last 3000 miles. At the same time we replaced: spark plugs, spark plug wires, new coilpacks, all new fuel injectors, ignition control module, felpro metal intake manifold gasket, all vacuum lines, gatorback supercharger belt, 180 degree thermostat and probably other odds and ends. Comes with a few parts as well.
Really the van drives awesome, it has never given me any weird engine swap related problems, if you didn't know any better and didn't get on the peddle you'd think it was a stock option. Everything in the van still works, including the front and rear AC and heat. With the intercooler I have never seen the KR at anything above 0.0 in any condition, even in the Florida weather and on the 3.2 pulley, so I believe this engine will last a long time. It's been very reliable for me during the time I've owned it, it's super fun, I just want something smaller and fuel efficient. I know it takes a certain person to buy this, so I'll entertain most offers, just message me or text the number in my craigslist ad. Thanks!
Pictures can be seen in my craigslist ad here: http://daytona.craigslist.org/cto/6241537338.html


text:
Darren Clarke ends long wait for major triumph
Darren Clarke raised his arms in celebration after tapping his final two-inch putt into the cup and the roar which greeted history could have launched a moon rocket.
The claret jug and a first golfing major was his at the 54th attempt at the age of 42 and in the 140 years of the Open championship it is doubtful if there has been a more popular victor than the man from Dungannon, County Tyrone.
Not old Tom Morris, nor Arnold Palmer, Gary Player and Jack Nicklaus. Maybe not even Britain's Tony Jacklin, nor the great Seve Ballesteros whose memory has been everywhere this past week in Sandwich.
We love Clarke because he loves a pint and a cigar and does not obsess over his fitness. We love his easy-going nature and his benevolent smile and the fact that he makes playing golf seem such a joy.
It explains why the Irishman was swept along the fairways and through the squalls which ravaged Royal St George's on a tide of goodwill, just as he was at the K Club in Ireland in 2006 when he helped Europe to win the Ryder Cup following the death of his wife.
This afternoon did not have the tears we witnessed then. Clarke is in a better place now with fiancee Alison and his life back in equilibrium.
And it showed as he held his nerve and engaged his 20 years of experience at the Open championship.
The technique, too, was sublime. Booming drives, raking long irons and clutch putts which saw him begin his round with a 16-footer to save par at the first, a 10-footer at the third and a 20-foot eagle at the seventh, after which he raised his finger to his lips to shush the crowd to silence as playing partner Dustin Johnson hovered over his own putt.
That is the measure of the man and the beauty of golf. Universal respect.
Yes, Clarke rode his luck, too, especially with one low trundler at the ninth which leapt the fairway bunker at the ninth like a thoroughbred taking Becher's Brook.
But there is not a winner in the history of the tournament who has not required a meaty slice of fortune.
In truth, however, it was Clarke's bold approach and his tenacious will which made him the oldest Open winner since Roberto di Vicenzo in 1967 and allowed him to stand firm when America's Phil Mickelson was compiling a front nine of 30 with four birdies and an eagle which was golf up there with the best the Open has ever witnessed.
Johnson might have proved a threat but his challenge faded with an aberration of a fairway iron at the 14th which sailed out of bounds and effectively left Clarke four shots clear.
The solid, composed Ulsterman was not going to lose from there, even if had been 10 years since he finished in the top 10 in a major.
Of course it was not supposed to be this way. The Irish contenders were supposed to be former US Open champion Graeme McDowell and the current US Open champion Rory McIlroy or perhaps two-times Open champion Padraig Harrington.
Clarke was barely given a mention by the experts, a 150-1 shot with the bookies before a ball was struck. Yet if the outcome was gloriously unpredictable then it mirrored four days at Sandwich which were never less than memorable.
Tom Lewis, the 20-year-old amateur, gave notice that one day he might be ready to join the rush of Englishmen currently at the top of the world game, taking the silver medal for leading amateur and garnishing it with a spectacular eagle at the seventh.
Tom Watson, the man Lewis was named after, ambled down the fairways, genial and composed even when the Sandwich weather was at its worst, demonstrating that even at 61 class remains permanent.
McIlroy visited hawthorn bushes and the deepest of rough as the muse of his US Open victory at Congressional deserted him.
Sergio Garcia briefly reminded us of his talent with one 80-odd foot putt right out of the Ballesteros textbook while fellow Spaniard Miguel Angel Jimenez fell away forlornly.
It was that sort of Open. No dominant force. Not until the final holes when Clarke enjoyed the luxury of a comfortable lead and the rest succumbed to the pressure and the wicked twists and bobbles of a testing course.
And when Clarke had beaten the course, the weather and everything the rest of the field could throw at him to win by three shots he wrapped his arms around the claret jug.
A sporting moment to savour. Warm and uplifting. Simply wonderful.
Belfast Telegraph
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- Irish eyes are smiling at the Open
- Darren Clarke thanks psychologists after a second 68 gives him a share of the lead
- Darren Clarke pops question to Alison Campbell
- Loved-up Darren Clarke and kids to settle back in Northern Ireland
- Glory, glory Rory McIlroy wins first major with astonishing display at US Open
- US Open 2010: Northern Ireland's Graeme McDowell wins US Open


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Ideal and cost-effective place to stay for a business or shopping visit to central Birmingham. Well-lit secure underground car parking with direct lift into lobby. This is a plus when street parking is on a meter and in generally short supply. Usual modern and practical rooms. No restaurant on site but within a short walk of Broad Street with numerous pubs clubs and restaurants. Asian restaurants are excellent. Tyr Jimmy Spice's buffet off Broad Street - all you can eat for £9.99. Standard fare at the continental breakfast included in the price but the dining area was not particularly cosy - particularly on the busy day we stayed. A 5 minute walk brings you to the new Bullring with more shops than you could visit in a day. The new Selfridges is well worth a visit if only for its architecture - with the interior as interesting and surprising as the space-age exterior. Room rate seemed a bit high at £85 but we stayed on a week-day and during a busy conference period. Well worth a return visit with the family - hopefully when the rate is a bit more realistic.
We just had our second Centerparcs mid-week break in Heijderbos in Holland. Last year we went to De Kempervennen, also in Holland, which was definately a better location with a slightly better aquadome. Cycling to local towns was easy and safe even for my 9 year old who learned to cycle during our stay. Facilities are good as they are at all the sites and the on site supermarket is excellent even if it does close too early for my liking. On-site restaurants are expensive for what they offer. Helpfully, Holland has some English TV with subtitles which made evening entertainment easier for my kids who tend to be hypnotised by the TV even if they can't understand whats being said. Unfortunately during our stay our accommodation was plagued by mosquitos which put us off re-visiting this location. However, we're all keen to do Centreparcs in Holland again because of the mix of activities, independence and easy access to the countryside.
I like Novotel. Uncompromisingly modern and unpretentious. If you look out for their regular special offers they can be surprisingly good value. We used the novotel in Heathrow for the second year in a row (our third stay) as a stopping off point in a driving holiday in Europe. I don't find it offers value when we travel out of the airport because of the lack of parking packages and its position outside the free bus system that runs into Heathrow. Although beginning to show its age it remains well maintained and modern. At £70 for 2 adults and 2 kids including an excellent buffet breakfast it was good value. Staff are efficient and attentive. Rooms are bright and modern although less grand that the 4 stars in the area. The pool is very small and the fitness room is very basic. The bar area is a pleasant atrium and the prices reasonable. Breakfast was of the usually good standard. Parking in a secure compound opposite the hotel is convenient.
Usual Travelodge room - you could be anywhere. A 3 storey building with a recent extension suggesting its well located and popular. Situated near cinemas and a choice of restaurants but the Little Chef on the premises is very convenient - especially for breakfast. Parking felt a bit unsafe - probably because the dedicated section was full and we had to use the "overflow" which was shared with fast food restaurants etc. The last thing you need on a motoring holiday is to lose your motor before you set off!! However we had no problems. Reasonably near the Channel Tunnel terminal. Ideal for an early morning start. A bit expensive (£60) when compared with nearby alternatives like Travel Inn (£45) which are also closer to the Tunnel terminal.
I'm not sure how to write a review about Heathrow. It would be like trying to write a review about a small city. However, one tip for travellers is the availability of free London Transport into the airport from the main Bath Road (Meridien, Rennaisance, Marriott hotels etc). In the past I've been encouraged to use the Heathrow Hopper at an exorbitant £3 per trip. London busses are not only more frequent but are FREE (I like that word). Its also better than using taxis since some of the taxi drivers leave a lot to be desired - try asking them to take you the short distance back to your hotel car park on the return trip! Well done London Transport.
The weekend rate with parking offers exceptional value for money. It?s a pity (for people like me travelling with two kids) that they seem to have reduced the maximum occupancy to 2 adults and a child recently. The location could hardly be better. Plane spotters will love the proximity of the main runway and the Heathrow visitor centre is right next door. For those like me who begrudge paying £3 each way for the Heathrow Hopper the main London Transport route is immediately outside and, since the hotel is within the Heathrow Free Transport Zone, you can get to the Airport bus terminal every few minutes - free. The rooms are standard international quality and restaurants expectedly pricey (McDonalds is opposite). One big drawback - especially if making comparisons with nearby hotels is that there is no pool.


text: On Wed, Nov 20, 2002 at 3:50 AM, Sven Luther wrote: >On Tue, Nov 19, 2002 at 10:25:09PM -0600, Michael Kahle wrote: >> This may be more appropriate on the debian-user list, if so, sorry. >> >> Wow, I have never been so stumped in my entire life! Please help... >> >> I have a IBM ZPro, 768MB, AIC-7889 SCSI, Matrox 450DH AGP Video. Debian was >> installed with Woody 3.0 r0. Then upgraded to the testing branch. I did >> this by changing my sources.list and then ... >> apt-get update >> dselect update >> dselect select >> dselect install > >Mmm, you upgraded from 4.1.0 (woody) to 4.2.1. Yes, I did. > >You were using the proprietary matrox drivers, which where built for >4.1.0, and are incompatible with 4.2.1. Actually, the file that I got from Matrox (mgadrivers-2.0.tgz) came with files compiled for 4.0.3, 4.1.0, and 4.2.0. I am using the 4.2.0 drivers. Sorry, I thought I made that clear in my original post. > >There was another thread on the same subject on this list a few days >ago, please read it. Nice. Link? The only one I found in the archives was: http://lists.debian.org/debian-x/2002/debian-x-200210/msg00296.html Similar problem, but different errors. I did read this post and the follow-ups very thoroughly. I have been working on this problem since Sunday night, so I have already read quite a bit of stuff myself. >Anyway, if i am not mistaken, you have two solution : > > o use the xfree86 provided mga driver. Tried it, doesn't work. > > o upgrade your proprietary matrox drivers to 4.2.[01] ones. Does 4.2.0 count? Where would I get the version you are refering to? Thanks for your time and comments. I would like to respectfully ask that when replying please just send to the list and not reply to me. Thanks again. Michael


text:
7/21, All cams, 10:20pm BBT
"Straight Craig from Omaha" and the girls do a dance in the backyard
Go back 10 minutes or so earlier for when "Craig" tries to pick up the ladies at the arcade
Printable View
7/21, All cams, 10:20pm BBT
"Straight Craig from Omaha" and the girls do a dance in the backyard
Go back 10 minutes or so earlier for when "Craig" tries to pick up the ladies at the arcade
note - flashback has now adjusted itself so that you must put in Big Brother Time, NOT your time
Thank God, finally! That was a big pain.
one of the funniest nights ever on the feeds....
7/29, begin around 9:15, the "inside group" gets alcohol and the hilarity escalates for the next hour or so
about 9:15 the group from the sushi party comes in and it starts to get crazy
this is a must-watch! :rofl
7/28, 12:55am, Cam 4 -- Britney's BB sex advice to Danielle after Shane gets called to the DR. Classic Brit!
7/30, 10:25am, Cam 2 -- In the HoH w/Britney, Shane says of Ian, "That pisses me off about Ian, that little f----t!" (Talking about Ian going against his word Week 1)
Bethany calls him out for saying it, and he takes it back right after, but it's like un-ringing a bell.
(EDIT: Britney, not Bethany -- too many windows open on my desktop)
Who is Bethany ;)
Britney's latest smear campaign against Janelle -- Janelle told Danielle those things that JoJo had said about Danielle's body being ugly and she has fat thighs etc... Britney is telling people now that JoJo never said those things, that Janelle made it all up, because she makes everything up.
Flashback 7/15, 4:15 pm, feeds 3/4, Janelle and JoJo in the bubble bath and JoJo is trashing the way Danielle looks
8/8, 12:18 am, Cam 3/4, Britney lying in the HOH bed between Shane and Danielle doing "relationship counseling" :rofl
8/8, 10:35 pm, Cams 3/4, Shane and Danielle wrestling match, Danielle flashes her bottom side all over. #savetrey


text:
It's total shit, but it's in my past, and because I have lived through this, I believe that me, my H, and all the close people that have lived through the recovery with me/us will be far far FAR less likely to make the same stupid mistake as a WS.
There are thousands, if not millions, of ways to achieve that same growth by making choices other than to have an affair.
To have an affair while in a relationship that a person cares about, he or she has to be self-centered. If they think about the person they're betraying, they can't continue the affair, so they work hard at not thinking about their spouses and try to justify their horrible choices by re-imagining their marriage/relationship as much worse than it actually is.
Once in the affair, they're attractive because they offer a escape from reality. There are no bills, children or other distractions. The betrayed spouse is usually a responsible person who takes care of all that to keep their lives from falling apart, even if the betrayer seems to be disengaging more and more.
At least that's my understanding/interpretation of what I'm being told. Ultimately it comes down to extreme selfishness.
The "why" question is so hard for me as well because I am naturally a rule follower and I always consider consequences. No matter how hard I try to understand how my H could have betrayed me this way I just can't understand it. And I think that's the key, he's broken and I'm not. My way of thinking can't possibly explain his way of thinking.
Is he looking for the why? I think that's his job, not yours. If he is then let him do that hard work, if he's not then tell him he needs to.
I also think it is important to see the affair as something that didn't just happen. The word "incremental" is critical to helping understand why, IMO.
My fWH found a tremendous amount of insight by doing a life timeline with his IC. He was able to see how slowly over time he incrementally thought things, did things, avoided things that simply ripened him for an affair. His detachment from himself and from me was a slow chipping away, and not this automatic shift that said "hey, it's OK to cheat - I think I'll do that!"
For me, getting to the heart of the "WHY?" was so critical to my acceptance of what happened. I'd find myself saying, how can I accept what's happened if I don't understand why it's happened? How can I feel safe that this won't happen again if my fWH doesn't even know why he got into the mess in the first place?
Why did my H have an affair? He's uncovered lots of reasons why - none of them simple and not one thing in particular. Incrementally he made choices that eventually landed him in an affair. Sadly, there will never be a satisfactory or justifiable reason. My fWH coming to this realization added to his remorse. He now says in disbelief "I threw it all away for something so worthless and stupid!" .
I think there is some commonality among WSs, but the details are unique to each person.
Like looking for spirituality in the toaster.
[This message edited by Morhurt at 4:32 PM, January 19th (Sunday)]
I appreciate everyone's responses and will try to keep them in mind.
It just doesn't make any sense to me.
I accept WW is broken... But why break me/us too?!?!
The smart man divorces a lawyer.
The smarter man never marries one in the first place.
To her we were never worth the effort. :-/
It's almost like putting a 50 000 piece puzzle together...without a picture on the box to guide you...
Anyhow, I found a thread on "I can relate"..."BS questions to former WS"...I found it very helpful...seems all BS have the same basic questions..."Why???" is just one of many.
Something else that breaks my heart...the fact that there are so many of us! Where did society go wrong??? What can we do to ensure our children don't land up in this same situation...as BS or WS???
My H was an incremental cheater. He did not actively look for a hook up. If the OW had walked up to him the day they met and said, "Lets f**k", he would have run like a scared rabbit. The IC said he had to be wowed , inch by inch, until one day he woke up and realized the ego strokes were good and he wanted more. And more. Then near obsession took over and he kept ignoring his inner voice. The compartmentalization, the breached boundaries, and his ego became his enemy. In order to live with himself he transferred that enemy to me. I was his adversary and the OW was his savior from such a horrid life. His internal crap escalated until boom, sex, sex, and more sex. He had convinced himself that I would not care if he left and we divorced. Then on DDay, all of the false walls came crashing down and the naked truth that he had been having a full A crushed the fantasy like a bug. At least that is what IC says.
IC also said the why or reason is not the excuse. There is no excuse for leaving a marital spouse, unaware, and bringing a third party into the marriage. Even though my H followed down a common path, he could have changed directions at anytime. He could have said no, I am not going to do his. He did not. That is why I am here, he said yes up until DDay 2.
You can therapy out the whys pretty easily. Accepting the "why nots", very hard.
Freedom's just another word for nothin' left to lose
I slowly became the enemy to my h.
Who is also extremely selfish.
All good answers here, I can relate our situation to most everyone.
Incredibly sad though, that life becomes so broken down.
FracturedSoul, your not pathetic, your normal for this mess we're all in.
Spent the whole day crying and feeling sorry for myself...pathetic, I know...
Just wanted to pop in here and tell you that you are not pathetic. This is normal and you have to give yourself permission to feel how you feel. Don't be hard on yourself.


text:
Article Continues Below
When Virginia Tech junior quarterback Logan Thomas faced Clemson last year and even in going back and reviewing the tape of either game, he sees some familiarities.
Though the Tigers have an abundance of playmakers and more of a spread attack, there's some similarities with the Hokies. Virginia Tech hasn't had the success overall that Clemson has, but Thomas sees the similar traits.
"Any team that's gonna go four-wide and do a little bit of motioning and handing off to receivers and stuff like that, they're gonna have some of the same elements," he said. "We have some of the likeness that they do and they have some of the likeness that we do. But both offense are kind of the same. They would like to establish the run first of all, to open up the past."
After yet another slow start against Duke Saturday, the Hokies' offense showed what it was capable of, piling up 525 yards, mostly in the second half. Freshman running back J.C. Coleman himself accounted for 183 yards rushing.
"JC's a heck of a back, just like the other three are for us," Thomas said. "I guess it wouldn't just be JC, it's just the running game in general helps out a quarterback so much inwards of where they have to expect the run and have to play the run and not rely on us to just go to the pass. When the run game is working, we're able to open it up downfield, able to pretty much do what we want. When we're balanced, we're tough to beat and it keeps them off-balanced. That's the way we need to play, that's the way we've played in the past and hopefully that's the way we'll continue to play."
Thomas also got moving through the air again, hooking up with senior wide receiver Marcus Davis for five catches and 144 yards before Davis left with a shoulder injury. Thomas also had a connection with tight ends Ryan Malleck and Randall Dunn on a few big catches over the middle.
"That's just where my read took me," Thomas said. "Those two guys, Ryan Malleck and Randall Dunn, I kinda expect them to win pretty much every time they're matched up on a linebacker or on a safety for that matter. Both of them are great route runners, good pass catchers and have a lot of heart. Both of them made some huge plays for us down the field and we need to continue to keep that production going."
But Thomas lost his starting center in the third quarter against Duke as junior Andrew Miller fractured his left leg and will miss the rest of the season after having surgery Sunday. Michael Via steppend in at center, albeit with a few immediate flubs.
"Mike Via is a great player and he's played all four positions on the line, I guess," Thomas said. "I have full faith in him. I've worked with him for a couple of years now. We had a couple of mis-snaps and stuff on Saturday, but he was kinda just thrown into the role since Caleb Farris went down with his injury. But we had a great day yesterday, no bad snaps and everything went smoothly. In front of me, I expect Becton, Painter, Via, Benedict and Arkema to be the five unless Wang or Caleb can come back."
After the Hokies' offensive outburst Saturday, Thomas hopes to continue the momentum, especially right off the bat against Clemson. The Tigers' taking both games against Virginia Tech last season still resonates with Thomas, even though they try not to overthink about it.
"We don't really need to talk about it," Thomas said. "All of us were here and we all understand. We know what we need to do and we know what's expected and what to expect when it comes to them. We know they're gonna give us their all, just like they did last year. Yeah, we keep it in the back of our minds just so we can pull it up when we need it. It's extra motivation and hopefully, we can go down there and steal one from their home turf, like they did from us last year."


text:
Jack Osbourne is planning to move out of The Osbournes' family home in Beverly Hills after offering to buy sister AIMEE's Los Angeles house.
Ozzy and SHARON's son, who turned 18 in November (03), hopes to take over his big sister's pad when she moves to New York later this year (04).
And, unlike sister KELLY, Jack insists he won't return home.
He says, "Kelly bought a place, had it completely redone inside; it was, like, amazing.
"She decided she didn't like it, sold it, rented an apartment, moved all her stuff in there, and has never spent a night there."04/02/2004 13:39


text:
New round of Elder Scrolls Online beta invites sent out
Check those emails, folks. Bethesda has reportedly sent out another batch of beta invites for ZeniMax Onlike Studio's highly anticipated massively multiplayer online role-playing game, The Elder Scrolls Online.
"The Elder Scrolls Online team is kicking off the new year with a new round of beta invites," Bethesda wrote. "Check your registered email address to find out if you received one, and don't forget to look in your spam folder just in case. Remember, if you use Gmail, our invites will be automatically filtered to the "promotions" tab."
With the PC version of The Elder Scrolls Online launching on April 4, 2014, expect Bethesda and ZeniMax to ramp up the beta in the coming weeks. Meanwhile, the Xbox One and PS4 versions won't be releasing until some time in June 2014. The MMORPG will cost $59.99 no all platforms, with an additional $14.99 monthly subscription required after the first month.


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text: On 2/5/07, ajb at spamcop.net <ajb at spamcop.net> wrote: > Quoting TJ <tjay.dreaming at gmail.com>: > > > I would think that with 100% laziness, nothing would happen until the > > Haskell program needed to output data to, e.g. the console. Quite > > obviously that's not it. So how is laziness defined in Haskell? > > It means that the program behaves as if "things" are evaluated if and > only if they are needed. "Needed" in the Haskell sense, means "needed > to do I/O". So it's just IO which makes things run huh? OK that's basically what I said there. Cool. > > This is one of the things that just boggles my mind everytime I try to > > wrap it around this thing called Haskell ;) > > The cool part is that for the most part, it doesn't matter. It just > works. If you ever come across a case where it doesn't just work (e.g. > if you need a tilde pattern), you'll be ready for it. I despise using what I don't understand. It's a big problem but one which is more insurmountable than understanding Haskell, I think... On 2/5/07, Andrew Wagner <wagner.andrew at gmail.com> wrote: > I found it useful to work through an example where lazy evaluation was > important, and wrote it up in a tutorial. It may or may not help you, > no guarantees, but here it is: > http://www.haskell.org/haskellwiki/Haskell/Lazy_Evaluation With the code from your tutorial, magic :: Int -> Int -> [Int] magic 0 _ = [] magic m n = m : (magic n (m+n)) getIt :: [Int] -> Int -> Int getIt [] _ = 0 getIt (x:xs) 1 = x getIt (x:xs) n = getIt xs (n-1) and the example expression, getIt (magic 1 1) 3 It only gets run (starts pattern matching and all) if I do a print on it, or run it from GHCi (which will do the"print" for me), right? Thanks, TJ


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text: Man Charged With Faking His Way Into Harvard News & Features NPR · May 18, 2010 Listen Story audio 1min 12sec Copyright 2017 NPR. Stay Informed The news on your schedule from MPR News Update Email Address* Zip Code MPR News Update AM MPR News Update PM See our Privacy Policy. Must be age 13.


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Pretoria - Two workers were rescued from a gas-contaminated sewage drain they were attempting to unblock in the Pretoria CBD on Monday, paramedics said.
It is believed that a man went to help his co-worker who was suffocating beneath the sewage drain at the intersection of Potgieter and Skinner streets around 09:30, Netcare911 spokesperson Chris Botha said.
However, both were overcome by the gas and collapsed.
Paramedics and fire-fighters called to the scene used breathing apparatus and ropes to enter the drain and rescue the pair, said Botha.
They were removed to the road side, where one of them was resuscitated and placed on a ventilator.
Tshwane fire station spokesperson Johan Pieterse said the men were not wearing full protective gear as required by law when they entered the manhole.
He said one of the men was taken to Eugene Marais hospital in a serious condition while the other was critical.


text:
Massachusetts Governor Michael Dukakis was a long-distance runner before it was cool, finishing the Boston Marathon as a high school senior in 1951. His political career had its own Heartbreak Hill, a devastating primary defeat when he first sought re-election as Governor in 1978. But Dukakis hit his stride with a comeback victory in 1982, and since then has compiled a record of achievement from welfare reform to tax reduction that has earned him a laurel wreath as one of the best Governors in the country. Last week Dukakis embarked on the most grueling endurance race of them all, an uphill...
Marathon Man: Dukakis signs up for the race
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MEXICO CITY, Jan 8 (Reuters) - Mexico's exchange rate may have been affected by a market over-reaction over China, and once things calm down, it should reflect Mexico's economic fundamentals and appreciate, Bank of Mexico Governor Agustin Carstens said on Friday.
Mexico's peso has hit a series of record lows against the dollar in recent days, with fears over Chinese markets and the low global oil price battering the currency. (Reporting by Michael O'Boyle)


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List price: $16.95Copyright year: 2003Publisher: Basic BooksPublication date: 6/11/2003Binding: PaperbackPages: 256Size: 5.50" wide x 8.25" long x 1.00" tall Weight: 0.594Language: English
Lynn Margulis was born in Chicago, Illinois on March 5, 1938. She graduated from the University of Chicago at the age of 18. She received a master's degree in genetics and zoology from the University of Wisconsin and a Ph.D. in genetics from the University of California, Berkeley. She taught for 22 years at Boston University before joining the faculty at the University of Massachusetts, Amherst in 1988. She was best known for her theory of species evolution by symbiogensis. The manuscript in which she first presented her findings was published in 1967 by the Journal of Theoretical Biology. An expanded version, with additional evidence to support the theory, became her first book entitled Origin of Eukaryotic Cells. Her other works include Symbiosis in Cell Evolution, Luminous Fish: Tales of Science and Love, Dazzle Gradually: Reflections on the Nature of Nature, and Mind, Life, and Universe: Conversations with Great Scientists of Our Time. She died five days after suffering a hemorrhagic stroke on November 22, 2011 at the age of 73.
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A friend of our publication, Jacob Jones, just emailed us to let us know that he has tested over 2,000+ VSTs to start a list of his 30 (and growing) favorite Free VSTS Software Synths and effects! You can find his list at the aptly named FreeSoftSynth.com
Hi, my name is Jacob, and I'm a professional musician who loves software synthesizers. In fact, in the past few years, I've tested over 2,000+ Free Soft Synths! People always ask me for recommendations for MIDI Software Synths & VSTs, so, I thought it would be easier to just put a list online, that way everyone could benefit! If anyone asks you for free software recommendations, feel free to send them to my site!
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text:
In the latest news from the Theocracy of Tinfoil Turbans comes word that Donald Trump, aka "Herr Rump," aka "Duh Fuhrer," may indeed be the second coming of Samson.
No, not the circus strongman, this one's the real deal. The one from the "good book," Judges 13-15.
Now, the last word I heard was that Herr Rump was the 2nd coming of John the Baptist, or maybe even J.C., himself! At least that's what ex Assembly of God bible thumper, Tom Horn, told Jim Bakker last month.
Maybe Horn was wrong or maybe Duh Fuhrer has a case of multiple personality disorder, amidst his many other mental maladies.
Anyway, Rick Wyles thinks he's Samson. No word on who Rick thinks Delilah is this time around.
For those of you who have not had the displeasure of knowing Rick, he's another troglodyte "Khristian," as opposed to "Christian." He's also the host of the "end times" and survivalist themed radio program, "Trunews." Despite its name, Trunews is not news and is definitely not true.
I've written about Rick a couple times in the past. In May of 2015, Rick predicted death and destruction if SCOTUS legalized gay marriage.
Claiming the Holy Ghost was speaking through him, he said there was fire in the future. The Sacred Spook wasn't sure if it was rioting, war or a fireball from space, but it was something.
America will be brought to its knees, there will be pain and suffering at a level we've never seen in this country. The word that I hear in my spirit is 'fire.' I do not know if it refers to riots or looting or war on American soil or a fireball from space. I simply know that a sweeping, consuming fire will come across the United States of America and this country will be charred and burned.
Herr Rump was elected, so maybe he was right on that one.
Then last February, after Justice Scalia bit the big one, Rick claimed he was the victim of a pagan sacrifice.
He broke the news to the world that Obama murdered Scalia as part of Lupercalia. Lupercalia, for those of you not hip to pagan holidays is supposed to avert evil spirits, releasing health and fertility. More than that, this ritual sacrifice also marked the beginning of the country being ruled by our pagan fascist overlords.
Hmm, once again, was he predicting Duh Fuhrer?
This Wednesday (1/25/17) Rick was as happy as a tick gorging on an elephant's butt.
Friends, listen to me," he said. "God's favor is on us. Please, please, please comprehend what is happening. It's more than a political revolution. This is a spiritual revolution. God's favor is shining on us. I can't get out of my mind what Mario Murillo said Monday, 'Grace is oozing out of Heaven.' It's just oozing towards us right now. I'm basking in it. I'm rolling around in it. I'm enjoying it
He went on to explain the cause of his euphoria,
I keep getting this picture that Donald Trump is like this Samson, who has been raised up by God to fight the Philistines and all the Philistines have now turned their attention away from the church, turned their attention away from attacking Christianity, and all of the Philistines are running to Washington to attack Samson. But Samson is strong enough for them. He's been called. He's been equipped for this battle. That is his job. That is his assignment. He's going to beat them down. They will not be able to overtake him. He's Samson. He was designed by God. He was created for this hour to fight these Philistines.
By "Philistines," I'm not sure if he was talking about the Women's March on Washington, the fact-checking press, the LGBT community, some descendants of the original Philistines, or just the majority of Americans in general. He was a bit vague on the matter.
But, in his "Us Against Them War," the "Philistines," whoever they are, are the enemy!


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Evesham, stood out in Worcestershire as being one of the few towns to favour Parliament over the King. The town itself lies in a strategic location, not only is Parliamentarian Warwickshire just a few miles away but it lies on Parliament's route to Gloucester and the west country from Coventry, and on the major Royalist supply route between Worcester and Oxford.
This area also proved to be an excellent recruiting ground for the Clubmen movement, several thousand were known to have congregated on Bredon Hill for a meeting in 1645 before declaring their support for Parliament.
Malcolm Atkin, a former county archaeologist, is a respected author on the Civil Wars and I have four of his books, covering the events in Worcestershire and in a slim volume, on the storming of Evesham itself. There is some great detail to be found here, raids and skirmishes were commonplace during this time, just the sort of thing to be recreated with The Pikeman's Lament. Some of my books are shown below;
Michael Arnold writes a series of books based in the English Civil War, with a 'Sharpe' like character called Stryker, a veteran of the Thirty Years War in mainland Europe. Lots more inspiration and ideas for scenarios here. In the fourth instalment, Assassin's Reign, Stryker finds himself down the road at the Siege of Gloucester. Knowing the city I've had fun looking at Google Earth and seeing where the defences were located.
Unbelievably this isnt this first time I tried to do ECW, over the years I bought 6mm, 10mm, 15mm and 28mm both twice. Previously I have been focused on the big battle but Im more motivated zooming down to skirmish level. I've started putting my figures together ( currently all Warlord) and what I've built and undercoated so far is shown below;
As with my WoTR project, I'm going to cover both sides, luckily all this needs is additional command figures painted with their Red or Tawney Orange sashes and the figures can swap sides. I'm going to paint up the troops in fairly generic colours.
My first box of the plastics are going to be blue, (not only were the Gloucester Trained Bands dressed in Blue but so were some of the opposing Evesham garrison) I'm thinking of green for the second box, the Dragoons will be in red and the firelock armed troops perhaps grey.
I'll post another update on this project as I move it forward, luckily Amazon have delivered the next two paperbacks in the Stryker series.


text:
The Occupation Corrupts From Above
The soldiers who harden their hearts at roadblocks, the pilots who loose bombs in the middle of cities, the attorneys who whitewash and the spokesmen who lie are not people who lack moral values. Most are merely victims of the situation created by the occupation.
The lie we were told about the Air Force's bombing of the Nusseirat refugee camp has very long tentacles. These tentacles start from the very highest echelons and do not skip over any sector of Israeli society. Their roots are planted deep in the territories, fed by the poison of the occupation.
Without lies, it would be impossible to talk about peace with the Palestinians for 36 years while at the same time seizing more and more Palestinian land. Without lies, it would be impossible to claim that there is no partner for the road map, while at the same time injecting more and more money into outposts that the road map calls for dismantling. Without lies, it would be impossible to promise "painful concessions" in exchange for peace, while at the same time terming people who concluded such an agreement "traitors."
Politicians who lie for the sake of ideology or political interests are nothing out of the ordinary. Yitzhak Shamir declared openly that "it is permissible to lie for the sake of the Land of Israel." When George W. Bush began his war on Iraq, he and the politicians who surround him flooded the American public with falsehoods. The problem is that in Israel, lying has become the norm among the working levels of the army, the legal establishment and the diplomatic corps. Lying has become a way of life for commanders and soldiers, lawyers and clerks, most of whom are far from having right-wing views and many of whom loathe the occupation.
While the politicians lie in order to perpetuate the occupation, the workers learn to lie in order to justify it. Israel Defense Forces soldiers have become used to seeing settlers prepare a road to yet another outpost in the morning, and then hearing on the radio in the evening that the defense minister and the prime minister "vehemently deny" the existence of any new outposts. So what do they do? They say (perhaps even to themselves) that this is a "security road."
Members of the Shin Bet security service know that not every Palestinian who was executed without trial was truly a "ticking bomb." They have become used to "cutting corners" and to living with the lie. Analysts understand that it is impossible to defeat a people fighting for its land and that there is no basis for the claim that there is no Palestinian partner for a fair division of the land. But they have learned that it does not pay to tell the leaders the truth.
There was great danger in the occupation even in the days when the four former Shin Bet chiefs were an inseparable part of it. But the view looks different from the other side. When Ami Ayalon and his colleagues were inside, they served the occupation. And in the nature of things, in order to justify the evils that are an inseparable part of ruling another nation by force, they also did not always adhere strictly to the truth.
Psychologist Arye Reshef, a former commander of the IDF's pilot training course who today researches the psychology of moral behavior, cites endless studies that show that very few people are immune to moral backsliding in situations that compel them to act in defiance of their basic values.
Gideon Kunda of Tel Aviv University, who researched the organizational culture of high-tech companies, writes that "through the desire to bind the worker and his soul to the organization's interest, organizations engage in constant brainwashing of their workers." Kunda quotes a manager who spoke of a culture of generally accepted lies: "If you want the project, you have to lie."
A pressurized situation or environment can drag individuals into acts even more severe than distorting the truth. A "normative" young man who testified at the Kafr Kassem trial in the 1960s (in which a group of Border Police were convicted of having shot and killed civilians who went out to work in their fields not knowing that a curfew had been imposed), said: "If I had been told that it would help the country to shoot at a kibbutz, I would also have done it." Psychologists who ran simulations of prison situations stopped them soon after they began when students who were asked to play the jailers demonstrated intolerable cruelty toward their "prisoner" colleagues.
The soldiers who harden their hearts at roadblocks, the pilots who loose bombs in the middle of cities, the attorneys who whitewash and the spokesmen who lie are not people who lack moral values. Most are merely victims of the situation created by the occupation.
But moral roadblocks know no borders. A moral roadblock removed from occupied Gaza will ultimately also come down in Tel Aviv.
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text:
A pair of Saskatchewan Roughriders are facing charges stemming from an alleged incident at a Regina nightclub last month.
Riders defensive back Dwight Anderson, 32, and wide receiver Taj Smith, 29, have both been charged with aggravated assault for allegedly sending a 20-year-old man to hospital during the early-morning hours of Aug. 18.
"As this matter is currently under investigation by Regina City Police, the organization will have no further comment until it's resolved," the Roughriders said in a statement Thursday.
According to Global News, Anderson and Smith appeared in court Thursday and were told to refrain from entering bars and consuming drugs and alcohol.
An investigation into the incident led to the CFLers' arrests on Wednesday.
They're scheduled to return to court on Oct. 8.


text:
Issue Date: August 19, 2013 | Web Date: August 16, 2013
White House To Encourage Adoption Of Digital Defenses
Keywords: cybersecurity, critical infrastructure, best practices, computer systems, hacker attacks
The White House says it may offer legal protections, less expensive insurance, and other incentives to encourage companies that own or operate "critical infrastructure"—including chemical plants, electric grids, and water systems—to join an evolving national cybersecurity program.
The inducements stem from an executive order President Barack Obama issued in February. That order calls for the National Institute of Standards & Technology (NIST) to work with industry to create a voluntary set of cybersecurity best practices to help safeguard critical computer systems from crippling hacker attacks.
NIST is required to produce a draft cybersecurity framework by October and publish a final version by February 2014 (C&EN, March 18, page 8).
The American Chemistry Council, an industry trade group, says it is encouraged that the White House "has recognized the important role that incentives can play in meeting the overall goals of the cybersecurity executive order."
To prod companies into adopting the completed framework, the White House is proposing to collaborate with the insurance industry in offering risk-based pricing for cybersecurity protection policies and to seek legislation that would shield companies from breach-of-privacy lawsuits in the event they share customer data and other sensitive information with government agencies.
Other possible incentives include providing rapid technical assistance and other government services to companies that put cyber protections in place. The Administration says it will decide which options to adopt within a few months.
- Chemical & Engineering News
- Copyright © American Chemical Society


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Phospho-Akt (Thr308) (C31E5E) Rabbit mAb (Alexa Fluor® 647 Conjugate) detects endogenous levels of Akt only when phosphorylated at Thr308.
Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues around Thr308 of mouse Akt. This antibody was conjugated to Alexa Fluor® 647 under optimal conditions with an F/P ratio of 2-6. The Alexa Fluor® 647 dye is maximally excited by red light (e.g. 633 nm He-Ne laser). Antibody conjugates of the Alexa Fluor® 647 dye produce bright far-red-fluorescence emission, with a peak at 665 nm.
This Cell Signaling Technology antibody is conjugated to Alexa Fluor® 647 fluorescent dye and tested in-house for direct flow cytometric analysis of human cells. The unconjugated antibody #2965 reacts with human, mouse, rat and monkey phospho-Akt (Thr308) protein. CST expects that Phospho-Akt (Thr308) (C31E5E) Rabbit mAb (Alexa Fluor® 647 Conjugate) will also recognize phospho-Akt (Thr308) in these species.
Akt, also referred to as PKB or Rac, plays a critical role in controlling survival and apoptosis (1-3). This protein kinase is activated by insulin and various growth and survival factors to function in a wortmannin-sensitive pathway involving PI3 kinase (2,3). Akt is activated by phospholipid binding and activation loop phosphorylation at Thr308 by PDK1 (4) and by phosphorylation within the carboxy terminus at Ser473. The previously elusive PDK2 responsible for phosphorylation of Akt at Ser473 has been identified as mammalian target of rapamycin (mTOR) in a rapamycin-insensitive complex with rictor and Sin1 (5,6). Akt promotes cell survival by inhibiting apoptosis through phosphorylation and inactivation of several targets, including Bad (7), forkhead transcription factors (8), c-Raf (9), and caspase-9. PTEN phosphatase is a major negative regulator of the PI3 kinase/Akt signaling pathway (10). LY294002 is a specific PI3 kinase inhibitor (11). Another essential Akt function is the regulation of glycogen synthesis through phosphorylation and inactivation of GSK-3α and β (12,13). Akt may also play a role in insulin stimulation of glucose transport (12). In addition to its role in survival and glycogen synthesis, Akt is involved in cell cycle regulation by preventing GSK-3β-mediated phosphorylation and degradation of cyclin D1 (14) and by negatively regulating the cyclin dependent kinase inhibitors p27 Kip1 (15) and p21 Waf1/Cip1 (16). Akt also plays a critical role in cell growth by directly phosphorylating mTOR in a rapamycin-sensitive complex containing raptor (17). More importantly, Akt phosphorylates and inactivates tuberin (TSC2), an inhibitor of mTOR within the mTOR-raptor complex (18,19).
1. Franke, T.F. et al. (1997) Cell 88, 435-7.
2. Burgering, B.M. and Coffer, P.J. (1995) Nature 376, 599-602.
3. Franke, T.F. et al. (1995) Cell 81, 727-36.
4. Alessi, D.R. et al. (1996) EMBO J 15, 6541-51.
5. Sarbassov, D.D. et al. (2005) Science 307, 1098-101.
6. Jacinto, E. et al. (2006) Cell 127, 125-37.
7. Cardone, M.H. et al. (1998) Science 282, 1318-21.
8. Brunet, A. et al. (1999) Cell 96, 857-68.
9. Zimmermann, S. and Moelling, K. (1999) Science 286, 1741-4.
10. Cantley, L.C. and Neel, B.G. (1999) Proc Natl Acad Sci USA 96, 4240-5.
11. Vlahos, C.J. et al. (1994) J Biol Chem 269, 5241-8.
12. Hajduch, E. et al. (2001) FEBS Lett 492, 199-203.
13. Cross, D.A. et al. (1995) Nature 378, 785-9.
14. Diehl, J.A. et al. (1998) Genes Dev 12, 3499-511.
15. Gesbert, F. et al. (2000) J Biol Chem 275, 39223-30.
16. Zhou, B.P. et al. (2001) Nat Cell Biol 3, 245-52.
17. Navé, B.T. et al. (1999) Biochem J 344 Pt 2, 427-31.
18. Inoki, K. et al. (2002) Nat Cell Biol 4, 648-57.
For Research Use Only. Not For Use In Diagnostic Procedures. Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc. The Alexa Fluor dye antibody conjugates in this product are sold under license from Life Technologies Corporation for research use only, except for use in combination with DNA microarrays. The Alexa Fluor® dyes (except for Alexa Fluor® 430 dye) are covered by pending and issued patents. Alexa Fluor® is a registered trademark of Molecular Probes, Inc. U.S. Patent No. 7,429,487, foreign equivalents, and child patents deriving therefrom.


text:
The Physiopathology, Metabolism and Nutrition Institute covers a very broad field of physiology, experimental medicine and human diseases. The areas covered are the lungs, heart and blood vessels, haemostasis, endocrine glands, liver, kidneys, skin, bones and joints, and all the organs involved in nutrition, from controlling appetite and dietary behaviour to the digestive processes and control of the use and storage of substrates.
The Institute is based on an Expert Committee representing each of the subject areas and representing the various research organisations involved. Research efforts are split, 29% in cardiovascular and haemostasis, 25% in metabolism, nutrition and diabetes, and 46% spread almost equally across osteoarticular, pneumology, nephrology, hepatology, endocrinology, gastroenterology and dermatology.
Metabolic and nutritional diseases are a major public health issue, because of their complications, particularly cardiovascular. Diabetes, hyperlipidaemia, obesity and kidney failure are major precursors of cardiovascular diseases, leading cause of death in industrialised countries. The continuing high incidence, despite major therapeutic advances, is explained by the increasing incidence of diabetes, obesity and ageing of the population. Diabetes alone affects 7.1% of the French population aged between 20 and 70 years old, obesity about 15%. Paradoxically, malnutrition is also a major problem. Malnutrition is observed in 40% of chronic diseases, in 30% to 50% of hospital patients, taking all pathologies combined. Other diseases falling into the Institutes subject areas are frequent and/or serious. They pose fundamental questions, whether they are autoimmune and inflammatory diseases, perfect example of multigenic and multifactorial diseases, monogenic genetic diseases, often disabling, numerous cancers or infectious diseases.
The biological problems posed involve a huge spectrum of disciplines, from genetics to developmental biology, cell biology, immunology, imaging, engineering, the biology of ageing and clinical research. The spectacular increase in the incidence of common diseases poses the question of the role of the environment as well as its interaction with a genome whose variability is becoming accessible as these diseases appear suddenly. Apart from rare monogenic diseases, common diseases are arising across a multigenic field that combines gene variants controlling as many intermediate phenotypic traits. Besides the genes that contribute to initiating these diseases, others yet to be identified contribute to their progression. These diseases require us to have biomarkers for their triggering and progression. There is a priority need for relevant preclinical models and extensively phenotyped patient cohorts.
For many of these diseases, current treatments are inadequate, often symptomatic or palliative. When they are based on mechanisms, they often clash with the risks they cause. When a preventive measure exists (atherosclerosis), it is often limited to targeting associated risk factors, which could only typify the physiopathological mechanisms involved. Organ replacement strategies, widespread in numerous fields of medicine, come up against the shortage of donors, the toxicity of immunosuppressants or the complexity of the surgical procedure. Changes are unavoidable to generate cells or tissues in vitro for use in transplants, to develop cell regeneration strategies, to make the immune system tolerate transplanted organs or to create artificial organs.
They are of three types: scientific, organisational and technological.
Ten scientific priorities have been identified:
The 9 functional priorities are:
Finally, the technological priorities relate to continuing to implement metabolomic platforms coordinated with existing genomic, transcriptomic and metabolomic platforms and to develop bio-informatics and biostatistics platforms. This technological policy must be considered in a coordinated way with objectives set by other institutes, particularly in the field of genetics and the genome, inflammation, public health and, of course, healthcare technologies.
Christian Boitard
Director of the Physiopathology, Metabolism and Nutrition Institute


text:
Cobbers sweep Minnesota Duals
The Concordia Cobbers had an historical evening at the Minnesota Duals Friday night in Perham.
The Cobbers won three duals - including two against NCAA Division III top 10 teams - and also had two wrestlers break the school record for career victories.
Seniors Justin Berns (157) and Phil Moenkedick (184) both won three matches to run their career win totals to 125, a new school record.
"It was fun," Cobbers head coach Clay Nagel said. "A lot of great things happened for our program."
Berns and Moenkedick were teammates in high school for Perham.
"A lot of Perham people here so it was cool," Nagel said. "It was pretty special for those guys."
Along with Berns and Moenkedick, Perham native Nathan Schmitz (197) won all three of his matches for the Cobbers. All three wrestlers combined to go 9-0 on the night.
No. 7-ranked Concordia beat No. 3 Augsburg 26-11; defeated No. 6 St. John's 32-10 and beat unranked St. Olaf 42-6 to complete a perfect night. Augsburg is the defending Division III champion.
Frazee natives Justin Skillings (St. Olaf) and Ben Anderson (Concordia) did not compete, Anderson due to injury and Skillings having just returned from Central America.
Bringing Division III wrestling to Perham was the idea of longtime Frazee writer and photographer John Dermody.
"Dermody suggested it years ago to bring some college wrestling here to this high school wrestling hot bed," Perham Athletic Director Fred Sailer said.
With Nagel involved, along with help from Perham Head Coach Robb Moser, Sailer was able to make the idea a reality.
"It's a wonderful idea for people to see something they've never seen before. It's a different sport than high school wrestling. It's exciting to have it here and wonderful for our community."
A Forum Communications staff report contributed to this story.
Concordia 26, Augsburg 11
125: Ben Presler (CC) dec. Josh Roberts (AUG) 4-2
133: Daron Hohbein (CC) maj. dec. Nathan Lexvold (AUG) 14-2.
141: David Baker (CC) dec. Will Keeter (AUG) 7-3.
149: Tony Valek (AUG) maj. dec. Jake Long (CC) 11-1.
157: Justin Berns (CC) maj. dec. Jon Priess (AUG) 14-2.
165: Orlando Ponce (AUG) maj. dec. Matt Jeska (CC) 11-3.
174: Zach Molitor (AUG) OT dec. Ross Dankers (CC) 12-10.
184: Phil Moenkedick (CC) pin fall Jackson Mboma (AUG) 2:11
197: Nathan Schmitz (CC) dec. Brad Baus (AUG) 7-4.
285: Tom Bouressa (CC) dec. Niko Bogojevic (AUG) 6-0.
Concordia 32, St. John's 10
125: Ben Presler (CC) wins by forfeit.
133: Chad Henle (SJU) dec. Daron Hohbein (CC) 8-5.
141: David Baker (CC) pin fall Alex Boosalis (SJU) 6:59.
149: Ryan Arne (SJU) dec. Jake Long (CC) 4-1.
157: Justin Berns (CC) maj. dec. John Vaith (SJU) 13-2.
165: Jordan Bendson (CC) dec. Chris Stevermer 7-5.
174: Nick Schuler (SJU) maj. dec. Ross Dankers (CC) 8-0.
184: Phil Moenkedick (CC) pin fall Dustin Raygor (SJU) :48.
197: Nathan Schmitz (CC) dec. Mitch Hagen (SJU) 8-2.
285: Tom Bouressa (CC) maj. dec. John Scepaniak (SJU) 8-0.
Concordia 42, St. Olaf 6
125: Ben Presler (CC) wins by forfeit.
133: Daron Hohbein (CC) wins by forfeit.
141: Ryan Timmerman (STO) pin fall David Baker (CC) 1:16.
149: Jake Long (CC) dec. Thomas Mork (STO) 8-7.
157: Justin Berns (CC) tech. fall Michael Roth (STO) 17-1 (3:00).
165: Matt Jeska (CC) maj. dec. Joey Waples (STO) 12-2.
174: Ross Dankers (CC) dec. Joseph Pesta (STO) 12-6.
184: Phil Moenkedick (CC) pin fall Andrew Rudd (STO) :42.
197: Nathan Schmitz (CC) dec. Joseph Schlueter (STO) 8-6.
285: Cody Kasprick (CC) pin fall Justin Luthey (STO) 1:53.


text: The music of oOoOO (San Francisco producer Christopher Dexter Greenspan) sounds a lot like his vowel-intensive name: a drawn-out exhalation of pleasure marked by languid, heavy bass pressure, gauzy synth washes, and opiated, diaphanous sampled vocals. A key figure in the newish genre known as drag, a meshing of chopped-and-screwed hiphop and gothy R&B, oOoOO creates aural reveries that are as sinister as they are beautiful. Heres hoping he redeems his truncated set at last years Decibel Festival. (Chop Suey, 1325 E Madison St, www.chopsuey.com, 9 pm, $10 adv, 21+)


text: I'm assuming most Harry Potter fans know about the Mugglenet website. Well, yesterday I stumbled across Mugglenet Interactive. It's one of those sites where you can get sorted into a house (and also a character), go to classes, earn galleons, etc. I am loving it so far! I highly suggest that HP fans check it out.


text:
|28 Oct 2009
PC to Home Theatre HDMI Audio problem
I have PC connected to a 22in TV via DVI, and I have the HDMI connected to a home theatre system shown below...
Discount Grundig Grundig GUHTS21 2.1 Channel Home Cinema HDMI, Divx DVD & Home Cinema from Cdiscount.co.uk
The sound system has a HDMI port so instead of playing the audio from my PC through the 3.5mm jack (poor quality) I wanted to play the audio through the HDMI cable.
However, when I connect it via HDMI and go to control panel>sound it shows a red arrow saying "not connected".
My graphics card is an integrated radion 4200.
Any ideas?
|My System Specs
|28 Oct 2009
Check the HDMI cable for defects. Use a different one if you can somehow, to test.
Could be that the driver isn't working so well or something of that nature.
|My System Specs
|28 Oct 2009
I was originally using the HDMI cable to connect the PC to the TV and it worked fine...
|My System Specs
|28 Oct 2009
From the link you posted to your HTIB,
Key Features
Model Number GUHTS21
Dolby Digital Yes
Audio Power Output (RMS) Total Output Power: 300 Watts (RMS)
Speakers Included Yes
DVD Recorder DVD Player DIVX Yes
MP3 Playback Yes
HDMI Output HDMI Connection with up Conversion
2.1 Channel Media System Yes
Dolby Pro Logic II Yes
|My System Specs
|28 Oct 2009
I assumed that as the audio system has a hdmi port, audio could be sent from my pc to the system. I assumed this because if I connect my tv to the audio system via hdmi it will play audio from the tv through the system...
|My System Specs
|28 Oct 2009
Nope, that isn't how it works; that HDMI port is output only. The system is processing/playing the audio all internally. To get audio in over HDMI the system needs to have a HDMI in port.
|My System Specs
|28 Oct 2009
|My System Specs
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Kids' Crocs Karin Sparkle Fuzz Lined Clog
*Offer valid online at crocs.com and crocs.ca. Valid on select products only. Discount applied in cart. Cannot be combined with any other offer or promotion. Offer valid while supplies last. Offer not valid on previous purchases. No rain checks. Offer ends Tuesday, November 21st, 2017 at 11:59pm MT.
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Kids' Crocs Karin Sparkle Lined Clog details:
James from Ft Polk, LA"Perfectly fit to my 20 months old daughter. She wears it even inside the house."
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Our most generous, roomy fit.
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Deep cushion: Feels soft with all day support.


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On Feb. 21, NC State became the first major school to offer speedy receiver Bo Hines of Charlotte Christian a scholarship. Exactly two weeks later Hines was back on the Raleigh campus for an unoffi...
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text:
Fast track to Anaheim by September 2011? Probably a bit too fast for the outfielder, but the Angels won't rule it out for the Midwest League MVP, who hit .362/.454/.526 at Cedar Rapids. Trout hit .306/.388/.434 at Rancho Cucamonga, and his stolen base success ratio dropped from 83 percent to 65 percent.
The Angels also were thrilled with Mark Trumbo, who batted .301/.368/.577 at Triple-A Salt Lake. He led the Pacific Coast League with 36 home runs, 103 runs and 122 RBIs. Trumbo's best position is first base, but he'll play outfield in winter ball to maximize his chances of breaking camp with the Angels next year.
Best Pitcher: The best pitchers also jumped leagues this season, twice each. The best overall, 20-year-old righthander Tyler Chatwood, went 8-3, 1.77 in 14 games at Rancho Cucamonga and 4-6, 3.82 in 12 games at Double-A Arkansas. The Angels promoted him to Salt Lake for his final start.
The best reliever, Michael Kohn, had a 2.45 ERA in 15 games at Arkansas and a 1.95 ERA in 26 games at Salt Lake. He held opponents to a combined .179 average. The Angels promoted him to Anaheim in July.
Keep An Eye On: Righthander Steven Geltz, 22, signed out of SUNY Buffalo as a nondrafted free agent two years ago. He just keeps putting up the strikeouts, even at 5-foot-10 and 170 pounds. He split this season between Rancho Cucamonga and Arkansas, with 87 strikeouts in 53 innings, holding opponents to a .159 average. The Angels will send him to the Arizona Fall League.
• In addition to Geltz, the Angels' AFL contingent includes righthanders Ryan Brasier and Eddie McKiernan, lefthander Robert Fish, shortstop Andrew Romine, outfielder Jeremy Moore—and infielder Brandon Wood, 25, the onetime top prospect given a last chance after batting .162/.188/.216 for the Angels.
• The Angels acquired 7-foot-1 righthander Loek Van Mil, 25, from the Twins for closer Brian Fuentes. Minnesota had designated him for assignment to make room on the roster for Fuentes.


text:
BevNET Live Day One Recap: In This Together
As Barry Nalebuff and Seth Goldman traded stories Wednesday on stage at BevNET Live in New York, it seemed as if the conference's attendees were being handed an inside look at the School of Organization and Management in New Haven. Nalebuff, co-founder of Honest Tea and Kombrewcha, teaches game theory at Yale University. Goldman, co-founder and CEO of Honest Tea, was a student of Nalebuff's at Yale. And here they were, chatting it up about the history of Honest Tea and the importance of a good partnership, seemingly forgetting the crowd before them.
While focused and informative, the conversation easily veered into jabs and laughs. Goldman hinted toward Nalebuff's occasionally insular personality.
"You are somebody who doesn't really see the world the way I do," Goldman said.
Nalebuff, who also specializes in self-deprecation, said that he just doesn't interact with people (students must not be people). On the contrary, he said that Goldman is naturally likeable. He pointed to Goldman's strong family background as a good sign of a business partner — it shows that somebody else can tolerate the guy, he said, drawing laughs from the crowd. With such a jovial breed of conversation, one wondered if ripping Harvard football was on deck.
Instead, it was all talk of their partnership, no jokes withheld.
"You don't want to find somebody that's better looking than you," Nalebluff said. "Because then they're going to get all the press."
Walking through the gestation and eventual boom of Honest Tea, Nalebuff and Goldman repeatedly praised the benefits of working together. Both bright and capable entrepreneurs, they admitted the shortcomings of going solo and touted each other's complementary abilities. Goldman has a knack for getting people on his side and for making cogent, rational decisions. Nalebuff asks the tough questions that are often overlooked by a natural proclivity of choosing what's easier or more comfortable.
There's a lesson here, smoothly extrapolated to the beverage industry as a whole. Sure, great ideas often sprout from one mind alone. And it's possible to thrive in this industry as a solo act, especially with a can't-miss brand. However, as Nalebuff and Goldman indicated in their discussion at the Metropolitan Pavilion, partnerships can offer entrepreneurs advantages that just can't be found alone.
After hearing the conference's diverse roster of speakers, one gets the idea that the industry supports this thinking. From entrepreneurs to retailers to investors, the many strands of the beverage industry believe in the movement of healthy, good-tasting innovation, and they believe in shaping the future together.
The evidence can be seen not just in the camaraderie of Nalebuff, flavored sweet and sour, curls in disarray, and the ever-smiling Goldman, but also in the investment world. Janica Lane, a managing director with investment bank Piper Jaffray, documented the active participation of investors and retailers with the industry's top innovations.
Boulder Brands and Alliance Consumer Growth, which aims to find and fuel next-generation versions of existing products, have both funded the growth of cold-pressed juice brand Suja, among other food and beverage outfits. Whole Foods has maintained its commitment to the Local Producer Loan Program, which provides up to $25 million of low-interest loans to local farmers and food artisans. On Wednesday morning, BevNET announced that Coke's Venturing and Emerging Brands group has purchased a minority stake in L.A. Libations, a West Coast incubation firm. The recent history points to a healthy stage of food and beverage business development polished by successful partnerships. Lane just hopes that these deals indicate emerging trends and not fads.
"I don't think I've ever seen the market quite like it is today around food and beverage," she said.
The evolution of togetherness was also examined by Kerry Corke, the head of U.S. operations for Kantar Worldpanel, a global market researcher and analytics supplier. Corke shared a case study of Coca-Cola and studied the brand by its history of slogans.
In 1896, it was the matter-of-fact: "Drink Coca-Cola." In 1979, "Have a Coke and a smile." In 1985, as the Cold War neared its end, "America's real choice." In 1993, "Always Coca-Cola." In 2003, "Coca-Cola Real." In 2009, "Open Happiness." And last year, acknowledging the heightened awareness of CSD ingredients and their relation to obesity and other ailments, Coke went with "Coming Together."
Even the major beverage powers like Coca-Cola are having a harder time of grabbing consumer attention, Corke said. This derives not only from the growing knowledge of health and wellness, but also because of brand proliferation. The consumers, she said, hold the power and sculpt the industry's identity.
"They're driving this change," Corke said.
Kantar Worldpanel research indicated that of more than 60 million consumers, 38 percent in 2003 cited relaxation as a reason for beverage consumption, compared to 44 percent in 2013. Of more than 48 million consumers, 23 percent in 2009 preferred drinking "all-natural" beverages, compared to 39 percent in 2013. Of more than 37 million consumers, 24 percent said in 2003 that they drink beverages to stay in shape, compared to 36 percent in 2014.
And what has influenced the industry's growing camaraderie? It might also be led by the actions of consumers. Of more than 15 million consumers, 15 percent said in 2009 that they drink something because it's sociable, compared to 20 percent in 2013.
As consumers drink healthier beverages together, the industry's many cogs continue to work together. When Coca-Cola acquired Honest Tea in March 2011, Goldman and Nalebuff realized that the purchase presented a new kind of challenge. They wanted to broaden their mission on their own terms while still working cordially and fluidly with a much larger partner in the cola giant.
They balanced this challenge by creating a three-year advisory board, from the point of Coke's first investment in the brand to the eventual purchase, keeping Nalebuff as an overseer of the brand's activity while Goldman continued to run the brand. By establishing the advisory board, the partnership with Coke has worked well, they said, following the blueprint set by their own partnership that began in a Yale classroom. And by Coke enabling both entrepreneurs to preserve important roles with the business, the deal accentuated the importance of the entrepreneur. Even when working alongside a massive company like Coca-Cola, they still have a say.
No matter a company's stage — startup, mid-sized or post-acquisition — the job of the entrepreneur never relents. There's production, sampling at retailers and trade shows, traveling to meet distributors, coordinating talks with investors, maintaining a content, productive staff at the home base. And that's just part of it. It helps to have others around.
"It's really too much to ask one person to be able to do all of those things," Nalebuff said.
Complete video coverage of Day 1 of BevNET Live Summer 2014 is NOW AVAILABLE on BevNET FBU, our on-demand video learning site for the food and beverage industry.


text:
GM China Sales Surge 11% In 2012
Sales at General Motors Co (NYSE: GM) and its joint ventures in China surged 11% y/y to 2.84 million vehicles in China in 2012.
Sales at GM and its joint venture with Shanghai's SAIC Motor gained 11% to 1.33 million units and sales at its joint venture with FAW Group climbed 12% to 1.45 million units.
Sales at SAIC-GM-Wuling Automobile Co dropped 0.9% to 55,609 units.
GM shares fell 0.09% to $30.33 in after-hours trading.
© 2017 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.


text: Sweeping views and grand Victorians, pride of place and person coalesce in an area embracing the "gay capital of the world." Castro, Diamond Heights/Twin Peaks, Glen Park, Noe Valley, Upper Market San Francisco's historic F-Line streetcars are one of the best ways to reach the Castro and Upper Market areas. The Castro, known at the "gay capital of the world," and nearby Noe Valley, offer village-like amenities including pedestrian-friendly streets, Victorian homes in historic Eureka Valley, an array of trendy stores and outdoor cafes for the "see and scene" crowd. The upper stretch of Market Street coils around the lower reaches of Twin Peaks. Noted for their sweeping vistas of the Bay Area, these crests are popular with sightseers. Glen Park on the lower slopes of Diamond Heights has a canyon park and is near a Bay Area Rapid Transit (BART) station. "Did you know the exact center of San Francisco is located at 20th and Douglass streets?"


text:
The Minnesota Department of Transportation will close several miles of Interstate 35E near the northern suburbs of Little Canada and Vadnais Heights on Saturday and Sunday.
The closed section starts at 694 and extends north to near Forest Lake. MnDOT spokesman Kent Barnard said both north and south segments of 35E will be closed. Barnard expects the major detour routes, which include 35W, will likely experience very heavy traffic.
"We are expecting it's going to be congested this weekend, especially if we have some nice weather with people trying to get out of town," Barnard said. "[Interstate] 35W could become a stop and go situation for us on the weekend."
The weekend 35E closure will allow crews to remove a bridge over the freeway.
Go to Transportation Nation for more of the latest transportation news from all across America.


text:
Luana Lugini0000-0002-8778-2601
Luana Lugini was born in Rome on March 5, 1976. In 2000, she graduated with honors in biological sciences, biotechnology specialization, from University of Rome "La Sapienza," Rome, Italy. In 2005, she completed her studies getting Ph.D. degree in experimental physiopathology at the Medicine Faculty, University of Rome, Tor Vergata. From 2000 to 2002 she worked at the Section of Tumour Immunology, Istituto Superiore di Sanità (ISS) to study (i) the interaction between actin cytoskeleton proteins and death receptors in T human lymphocytes and natural killer (NK) cells, (ii) drug resistance in human melanoma cell lines, and (iii) adoptive immunotherapy based on the use of NK cells in immunodeficient mice. In 2003 she registered a Patent (by IMED AB, 103 95 Stockholm, SWEDEN) consisting of a diagnostic test for the identification and evaluation of metastatic tumours. In 2003 she was awarded the "First Prize Onlus AICC 2003," reserved to young researchers, conferred by Italian Association of Cell Culture. She was also granted a triennial fellowship of Italian Federation of Cancer Research. In this period her research was mainly focused on human tumour immune escape mechanisms and in particular (i) the secretion of tumour exosomes bearing death receptors and (ii) tumour "cannibalic" activity, used by metastatic melanoma cells to entrap and digest live T lymphocytes. From 2005 she has a permanent position at the ISS, where she works as Researcher. Up till now her main research interests are tumour biology, cancer, NK cells-derived exosomes, and development of innovative anticancer strategies based on the use of antiacid drugs (PPI). She is author of 29 abstracts for National and International Conferences. She is author of 21 publications in international peer-reviewed journals.
Biography Updated on 30 April 2013


text:
I've been watching the terms people have used and ended up on my site. Some I understand. They make sense. Others? No idea, but they make me laugh! I thought it might be fun to share them with you every Sunday for the prior week. A stockpile of search terms, if you will. Here are my favorite from this last week.
- Car cleaning for spring break. Sounds like a great idea. Please clean mine, too!
- Mavi gokyuzu. I have now idea what that means. Should I be happy? Should I be offended? Someone please tell me how to feel about this one!
- Commpression socks make my calfs sore. Sore "calfs?" Interesting. Time for "commpression," for sure!
- Whine shoes. Where do I even start with this one?! Why are you whining about your shoes? Do you not like them? No return policy? I don't understand! Shoes usually make me happy.
Today was the final day of the 7-Day Green Smooth Challenge. Today's smoothie was a total flop. So bad, I didn't even drink it. I forgot to take a picture of the ingredients before putting them in the blender.
- container Fage cherry pomegranate Greek yogurt
- handful spinach
- 1 cup vanilla coconut milk
- 1/2 scoop vanilla whey protein powder
- 1 frozen banana
- 1 frozen kiwi
- 1/2 frozen orange
Not good. Not good at all. Do not, I repeat, do not make this. Ever. =(
What was your last cooking disaster?


text:
DORLET DOC access control systems can be used for different types of locks and uses, the latest being the management of container opening to recycle waste.
DORLET is pleased to offer a new service: the option of hiring software maintenance for each of the facilities.
© Dorlet 2011 · Parque Tecnológico de Álava · +34 945 29 87 90 · email@example.com