text:
Research Topics
Genomes and Genes
alcohol deterrents
Summary: Substances interfering with the metabolism of ethyl alcohol, causing unpleasant side effects thought to discourage the drinking of alcoholic beverages. Alcohol deterrents are used in the treatment of alcoholism.
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Scientific Experts
Detail Information
Publications176 found, 100 shown here
- Comparison of disulfiram and placebo in treatment of alcohol dependence of adolescentsHelmut Niederhofer
Christian Doppler Clinic, A 5020, Salzburg, Austria
Drug Alcohol Rev 22:295-7. 2003..In some cases, disulfiram may be an effective and well-tolerated pharmacological adjunct to psychosocial and behavioural treatment programmes for treatment of adolescent alcohol-dependent patients...
- The efficacy of disulfiram for the treatment of alcohol use disorderCharlotte H Jørgensen
WHO Collaborating Centre for Evidence Based Health Promotion in Hospitals and Health Services, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
Alcohol Clin Exp Res 35:1749-58. 2011....
- Effect of oral acamprosate on abstinence in patients with alcohol dependence in a double-blind, placebo-controlled trial: the role of patient motivationBarbara J Mason
The Pearson Center for Alcoholism and Addiction Research and Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, TPC 5, La Jolla, CA 92037, United States
J Psychiatr Res 40:383-93. 2006..The US study findings suggest that acamprosate is safe and well tolerated in a broadly inclusive sample of alcoholics and appears effective in populations of patients motivated to have a treatment goal of abstinence...
- Acamprosate and naltrexone treatment for alcohol dependence: an evidence-based risk-benefits assessmentBarbara J Mason
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA, USA
Eur Neuropsychopharmacol 13:469-75. 2003..The safety of the two drugs in combination has been supported by two independent double-blind studies, and combination treatment may offer an advantage for some patients...
- Does disulfiram have a role in alcoholism treatment today?Richard K Fuller
Addiction 99:21-4. 2004
- Medical treatment of alcohol dependence: a systematic reviewPeter M Miller
Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, SC 29425, USA
Int J Psychiatry Med 42:227-66. 2011..To summarize published data on pharmacologic treatments for alcohol dependence alone and in combination with brief psychosocial therapies that may be feasible for primary care and specialty medical settings...
- Comparing topiramate with naltrexone in the treatment of alcohol dependenceDanilo Antonio Baltieri
Department of Psychiatry of the University of São Paulo, Brazil
Addiction 103:2035-44. 2008..To compare the efficacy of topiramate with naltrexone in the treatment of alcohol dependence...
- Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trialRaymond F Anton
Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston 29425, USA
JAMA 295:2003-17. 2006..Alcohol dependence treatment may include medications, behavioral therapies, or both. It is unknown how combining these treatments may impact their effectiveness, especially in the context of primary care and other nonspecialty settings...
- Medication treatment of different types of alcoholismBankole A Johnson
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, 22908 0623, USA
Am J Psychiatry 167:630-9. 2010..Brief behavioral interventions that encourage the patient to set goals for a reduction in heavy drinking or abstinence also are part of optimal therapy...
- Efficacy and safety of naltrexone and acamprosate in the treatment of alcohol dependence: a systematic reviewCarmen Bouza
Agency for Health Technology Assessment, Madrid, Spain
Addiction 99:811-28. 2004..To ascertain the efficacy and safety of naltrexone and acamprosate in the treatment of alcohol dependence...
- The status of disulfiram: a half of a century laterJesse J Suh
Treatment Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
J Clin Psychopharmacol 26:290-302. 2006..Preliminary evidence also suggests that disulfiram treatment could be a viable treatment for cocaine dependence because it was shown to reduce cocaine use among nonalcoholic, cocaine-dependent patients...
- Review of topiramate: an antiepileptic for the treatment of alcohol dependenceGeorge A Kenna
Department of Psychiatry and Human Behavior, Center for Alcohol and Addiction Studies, Brown University, Providence, RI 02908, USA
Curr Drug Abuse Rev 2:135-42. 2009..While the manufacturer will not pursue approval of an indication for the treatment of alcohol dependence, the drug will soon be available generically, making it more affordable for a greater proportion of the public...
- Gabapentin reduces alcohol consumption and craving: a randomized, double-blind, placebo-controlled trialFernando A Furieri
Vitória Municipal Addiction Treatment Center, Vitoria, Espirito Santo, Brazil
J Clin Psychiatry 68:1691-700. 2007..This study examined the efficacy of a 28-day gabapentin treatment in reducing alcohol consumption and craving...
- Combined therapy: what does acamprosate and naltrexone combination tell us?Falk Kiefer
Department of Psychiatry, University Hospital of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
Alcohol Alcohol 39:542-7. 2004..It remains to be answered whether data justify the combination of both drugs in clinical practice...
- Pharmacotherapy of alcohol use disorders by the Veterans Health Administration: patterns of receipt and persistenceAlex H S Harris
Center for Health Care Evaluation, U S Department of Veterans Affairs VA Palo Alto Health Care System and Stanford University School of Medicine, 795 Willow Rd, 152 MPD, Menlo Park, CA 94025, USA
Psychiatr Serv 63:679-85. 2012..This study assessed changes since 2007 at Veterans Health Administration (VHA) facilities (N=129) in use of the medications approved by the U.S. Food and Drug Administration for treatment of alcohol use disorders...
- The effectiveness of continuing group psychotherapy for outpatients with alcohol dependence: 77-month outcomesJee Wook Kim
Department of Neuropsychiatry, Hangang Sacred Heart Hospital, Hallym University, Seoul, Korea
Alcohol Clin Exp Res 36:686-92. 2012..On that basis, a long-term comparative trial was performed with the main objective of evaluating the effectiveness of continuing group PT for outpatients with AD...
- Disulfiram attenuates drug-primed reinstatement of cocaine seeking via inhibition of dopamine β-hydroxylaseJason P Schroeder
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
Neuropsychopharmacology 35:2440-9. 2010..Our results suggest that disulfiram's efficacy in the treatment of cocaine addiction is associated with the inhibition of DBH and interference with the ability of environmental stimuli to trigger relapse...
- Efficacy of naltrexone and acamprosate for alcoholism treatment: a meta-analysisH R Kranzler
Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA
Alcohol Clin Exp Res 25:1335-41. 2001..In the absence of studies that compare the effects of these medications, we used a meta-analytic approach to the literature to compare their efficacy in alcoholism treatment...
- Naltrexone and disulfiram in patients with alcohol dependence and comorbid psychiatric disordersIsmene L Petrakis
Department of Psychiatry, Yale University, New Haven, Connecticut 06516, USA
Biol Psychiatry 57:1128-37. 2005..Disulfiram and naltrexone are approved by the Food and Drug Administration (FDA) for the treatment of alcoholism, but these agents have not been rigorously evaluated in dually diagnosed individuals...
- Pharmacotherapy of alcohol dependence: a review of the clinical dataKarl Mann
Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
CNS Drugs 18:485-504. 2004..Pharmacotherapy should be used in association with appropriate psychosocial support and specific treatment provided for any underlying psychiatric comorbidities...
- Pharmacological approaches to the management of alcohol addictionG Addolorato
Istituto di Medicina Interna, Universita Cattolica del Sacro Cuore, Roma
Eur Rev Med Pharmacol Sci 6:89-97. 2002..However, pharmacotherapy should not be considered as the only form of treatment but as an integrated part of a multimodal approach including psychological and social support...
- Disulfiram treatment for alcoholism in severe mental illnessKim T Mueser
Department of Psychiatry, Dartmouth Medical School, Concord, NH, USA
Am J Addict 12:242-52. 2003..The results suggest disulfiram may be a useful adjunctive treatment for alcoholism in patients with severe mental illness and that controlled research is needed to evaluate its effects in this population...
- New achievements and pharmacotherapeutic approaches in the treatment of alcohol dependenceFalk Kiefer
University of Heidelberg, Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, CIMH, J5, D 68159 Mannheim, Germany
Eur J Pharmacol 526:163-71. 2005..New compounds are under investigation. This review discusses the neurobiological basis of alcohol addiction, pharmacological targets for relapse prevention treatment and pre-clinical and clinical results with the most promising drugs...
- A one-year pragmatic trial of naltrexone vs disulfiram in the treatment of alcohol dependenceAlan de Sousa
Get Well Clinic and Nursing Home, 33rd Road, Off Linking Road, Bandra, Mumbai 400050, India
Alcohol Alcohol 39:528-31. 2004..To compare the efficacy of naltrexone and disulfiram in preventing an alcoholic relapse in routine clinical practice in an Indian metropolis...
- Pharmacotherapy, pharmacogenomics, and the future of alcohol dependence treatment, part 1George A Kenna
Center for Alcohol and Addiction Studies, Brown University, Providence, RI, USA
Am J Health Syst Pharm 61:2272-9. 2004..The neurobiological basis of alcohol dependence, established pharmacotherapies for alcohol dependence, pharmacotherapies under investigation, and obstacles to treatment are discussed...
- An open randomized study comparing disulfiram and acamprosate in the treatment of alcohol dependenceAvinash De Sousa
Get Well Clinic and Nursing Home, 33rd Road, Off Linking Road, Bandra, Mumbai 400050, Maharashtra State, India
Alcohol Alcohol 40:545-8. 2005..To compare the efficacy of acamprosate (ACP) and disulfiram (DSF) for preventing alcoholic relapse in routine clinical practice...
- [Pharmacology of disulfiram - an update]J Mutschler
Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Mannheim
Fortschr Neurol Psychiatr 76:225-31. 2008..As an example we demonstrate a case, in which an acute neurological deficit was misjudged as a side effect of Disulfiram. Furthermore, the potential of Disulfiram as a promising treatment in addiction medicine will be discussed...
- Alcohol dependence: analysis of factors associated with retention of patients in outpatient treatmentMárcia Fonsi Elbreder
Alcohol and Drugs Research Unit Uniad, Rua Botucatu 394 Vila Clementino CEP 04023 061, Sao Paulo SP, Brazil
Alcohol Alcohol 46:74-6. 2011..To identify factors associated with retention in treatment of alcohol-dependent individuals and to compare treatment retention between men and women...
- The use of disulfiram for alcohol-dependent patients and duration of outpatient treatmentMárcia Fonsi Elbreder
Department of Psychiatry, Federal University of Sao Paulo UNIFESP, Sao Paulo, Brazil
Eur Arch Psychiatry Clin Neurosci 260:191-5. 2010..Although disulfiram is an old medication, it seems that this drug can be useful for keeping alcohol-dependent patients under outpatient treatment...
- Paradigm to test a drug-induced aversion to ethanolE Garver
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Alcohol Alcohol 35:435-8. 2000..This model should be of value in the testing of new agents that reduce aldehyde dehydrogenase levels for prolonged periods for their potential as an aversive treatment in alcoholism...
- [The role of the glutamatergic system in the pathogenesis and treatment of alcohol dependence]Karina Łukasik
Zakład Farmakodynamiki Uniwersytetu Medycznego w Łodzi, Łódź
Postepy Hig Med Dosw (Online) 64:534-43. 2010..There are promising preclinical results of groups I and II metabotropic receptor antagonists. However, further studies are necessary to elucidate precisely their role in alcohol dependence...
- Supervised disulfiram as adjunct to psychotherapy in alcoholism treatmentHenning Krampe
Department of Anaesthesiology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Germany
Curr Pharm Des 16:2076-90. 2010....
- Economic evaluation of Campral (Acamprosate) compared to placebo in maintaining abstinence in alcohol-dependent patientsL Annemans
Vrije Universiteit Brussel, Brussels, Belgium
Eur Addict Res 6:71-8. 2000..A global anticipated net saving of 70 million BEF (1.74 million Euro) over 2 years was estimated for the Belgian health insurance...
- New pharmacotherapies for alcohol dependenceRobert Graham
St Vincent s Hospital, Sydney, NSW, Australia
Med J Aust 177:103-7. 2002..Adjunctive psychosocial treatment with close follow-up is required for acamprosate and recommended for naltrexone. As yet, no studies have reported a reduction in mortality following the use of any pharmacotherapy for alcohol dependence...
- Why is disulfiram superior to acamprosate in the routine clinical setting? A retrospective long-term study in 353 alcohol-dependent patientsAlexander Diehl
Department of Psychiatry, Klinikum Braunschweig, Braunschweig, Germany
Alcohol Alcohol 45:271-7. 2010..To compare the long-term effectiveness of acamprosate (ACP) and disulfiram (DSF) in the treatment of alcohol dependence and their effectiveness in regard to patient characteristics, within a naturalistic outpatient treatment setting...
- Disulfiram impairs the development of behavioural sensitization to the stimulant effect of ethanolAndrezza Kyunmi Kim
Departamento de Psicobiologia Universidade Federal de São Paulo UNIFESP, Rua Napoleao de Barros 925, Sao Paulo, Sao Paulo, Brazil
Behav Brain Res 207:441-6. 2010..This study sought to analyze the influence of disulfiram on the development of behavioural sensitization to the stimulant effect of ethanol...
- Safety issues concerning the use of disulfiram in treating alcohol dependenceJ Chick
Department of Psychiatry, University of Edinburgh, Scotland
Drug Saf 20:427-35. 1999..Disulfiram can be viewed as a drug with a moderate record of adverse effects. Alcohol dependence, for which it can be a helpful treatment, is associated with a high morbidity and mortality...
- Acamprosate in Korean alcohol-dependent patients: a multi-centre, randomized, double-blind, placebo-controlled studyKee Namkoong
Department of Psychiatry, Yonsei University College of Medicine, Seoul, South Korea
Alcohol Alcohol 38:135-41. 2003..A multi-centre, randomized, double-blind, placebo-controlled trial was conducted to evaluate the efficacy and the safety of acamprosate over 8 weeks in Korean alcohol-dependent patients...
- Predictors of acamprosate efficacy: results from a pooled analysis of seven European trials including 1485 alcohol-dependent patientsRoel Verheul
Department of Clinical Psychology, University of Amsterdam, Amsterdam, The Netherlands
Psychopharmacology (Berl) 178:167-73. 2005..However, acamprosate prevents lapses or relapses only in a minority of patients. An important question, therefore, is whether there is a specific subgroup of patients who respond particularly well to acamprosate...
- Modulation of impulsivity by topiramate: implications for the treatment of alcohol dependenceGabriel Rubio
Dual Diagnoses Unit, Department of Psychiatry, Hospital Universitario 12 de Octubre, Madrid, Spain
J Clin Psychopharmacol 29:584-9. 2009..The results of this study indicate that TP reduces drinking and that the mechanisms underlying this effect may involve, at least in part, modulation of the behavioral inhibition paradigm...
- Pharmacotherapy of alcohol use disorders in the Veterans Health AdministrationAlex H S Harris
Center for Health Care Evaluation, Department of Veterans Affairs Palo Alto Health Care System, 795 Willow Rd MC152, Menlo Park, CA 94025, USA
Psychiatr Serv 61:392-8. 2010..Their availability and consideration of their use in treatment are now standards of high-quality care. This study determined rates of medication initiation among Veterans Health Administration (VHA) patients...
- Combining psychosocial treatment with pharmacotherapy for alcohol dependenceRoger D Weiss
Alcohol and Drug Abuse Treatment Program, McLean Hospital, Belmont, MA 02478, USA
J Clin Psychopharmacol 26:S37-42. 2006..Ongoing research examining the optimal combinations of medications with different psychosocial treatments for alcohol dependence may further inform the field...
- Treatment of alcohol-dependent outpatients with acamprosate: a clinical reviewB J Mason
Department of Psychiatry and Behavioral Sciences, University of Miami/JMH Medical Center, Fla 33136, USA
J Clin Psychiatry 62:42-8. 2001..The drug's reliable effect on prolonging abstinence, in conjunction with an excellent safety profile, suggests that acamprosate may be useful for a broad range of patients with alcohol dependence...
- A critical review of pharmacoeconomic studies of acamprosateFlavio Poldrugo
Office for Research and Innovative Projects on Alcohol, Other Addictions and Mental Health, Department of Psychiatry, University of Trieste, Via De Pastrovich 5 A, 34126 TRIESTE, Italy
Alcohol Alcohol 40:422-30. 2005..This review assessed the published data on the cost-effectiveness of acamprosate for the treatment of alcohol dependence...
- Interest in pharmacotherapy and primary care alcoholism treatment among medically hospitalized, alcohol dependent patientsScott H Stewart
Psychiatry and Medicine, Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, SC 29425, USA
J Addict Dis 26:63-9. 2007..Medically hospitalized patients with alcohol dependence were interested in effective medication for relapse prevention, but primary care follow-up alone may not adequately address patients' perceived treatment needs...
- Medications for treating alcohol dependenceSteven H Williams
Psychology Service, Veterans Affairs Medical Center, Lebanon, Pennsylvania 17042, USA
Am Fam Physician 72:1775-80. 2005..S. Food and Drug Administration for this indication, the anticonvulsant topiramate and several serotonergic agents (e.g., fluoxetine, ondansetron) have been shown in recent studies to increase abstinence rates and decrease drinking...
- Follow-up of 180 alcoholic patients for up to 7 years after outpatient treatment: impact of alcohol deterrents on outcomeHenning Krampe
Department of Psychiatry and Psychotherapy, Georg August University, and Max Planck Institute of Experimental Medicine, Goettingen, Germany
Alcohol Clin Exp Res 30:86-95. 2006..patients, participants of the Outpatient Longterm Intensive Therapy for Alcoholics (OLITA); (2) To investigate the role of supervised alcohol deterrents (AD) in relapse prevention and as an adjunct for maintenance of long-term abstinence.
- Metadoxine in the treatment of acute and chronic alcoholism: a reviewG Addolorato
Institute of Internal Medicine, Catholic University of Rome, Italy
Int J Immunopathol Pharmacol 16:207-14. 2003..In this review the preclinical and clinical results obtained using metadoxine in acute and chronic alcohol intoxication are reported...
- Metadoxine in acute alcohol intoxication: a double-blind, randomized, placebo-controlled studyLeonid S Shpilenya
Narcological County Dispensary, Vasyleostrovsky District 4 th, Line V 0 2 3 2 5, St Petersburg, Russia
Alcohol Clin Exp Res 26:340-6. 2002..The present study was planned with the aim of investigating the effectiveness of metadoxine in the management of patients affected by acute ethanol intoxication...
- Use of pharmacotherapies for the management of addictive behaviours in Australian clinical practiceChristopher M Doran
School of Population Health, School of Economics, University of Queensland, Mayne Medical Building, Herston Road, Herston QLD 4006, Australia
Addict Behav 31:1947-58. 2006..To collect data on the behaviours associated with the prescription of pharmacotherapies (bupropion, acamprosate and naltrexone) for nicotine and alcohol dependence in Australian clinical practice...
- Pharmacotherapy for alcohol dependence: anticraving medications for relapse preventionYoung Chul Jung
Department of Psychiatry, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun gu, Seoul 120 752, Korea
Yonsei Med J 47:167-78. 2006..In addition, novel medications are being investigated to assess their efficacy in preventing relapse and increasing abstinence...
- Pharmacological treatment of alcohol dependence: target symptoms and target mechanismsMarkus Heilig
National Institute on Alcohol Abuse and Alcoholism NIH DHHS, 10 Center Drive, 10 1E 5334 Bethesda, MD 20892 1610, United States
Pharmacol Ther 111:855-76. 2006..Once novel treatments are developed, the field faces a major challenge to assure their delivery to patients...
- Naltrexone and disulfiram in patients with alcohol dependence and current depressionIsmene Petrakis
Department of Psychiatry, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, West Haven Campus, West Haven, CT 06516, USA
J Clin Psychopharmacol 27:160-5. 2007..In particular, the effect of these medications on alcohol use outcomes and on specific psychiatric symptoms is still unknown in patients with the most common co-occurring disorder, major depression...
- Hypothalamic-pituitary-adrenocortical axis activity: a target of pharmacological anticraving treatment?Falk Kiefer
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
Biol Psychiatry 60:74-6. 2006..We examined the relationship between efficacy of pharmacological anticraving treatment and HPA axis activity in the relapse prevention treatment of alcoholism...
- Combined acamprosate and naltrexone, with cognitive behavioural therapy is superior to either medication alone for alcohol abstinence: a single centres' experience with pharmacotherapyGerald F X Feeney
Alcohol and Drug Assessment Unit, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia
Alcohol Alcohol 41:321-7. 2006..To compare treatment outcomes amongst patients offered pharmacotherapy with either naltrexone or acamprosate used singly or in combination, in a 12-week outpatient cognitive behavioural therapy (CBT) programme for alcohol dependence...
- Alcoholism and suicidal behavior: a clinical overviewL Sher
Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
Acta Psychiatr Scand 113:13-22. 2006..The purpose of this paper was to provide a clinical review of the literature on the relation of alcoholism to suicidal behavior...
- Pharmacotherapy of alcohol use disordersAlessandra Buonopane
Department of Psychiatry, School of Medicine, Yale University, New Haven, Connecticut, USA
Subst Use Misuse 40:2001-20, 2043-8. 2005..An overview of the serotonergic agents is also provided. Finally, future directions, including new medications and some clinical strategies that show promise but are not yet used extensively clinically, are mentioned...
- Trends in the adoption of medications for alcohol dependenceLori J Ducharme
Institute for Behavioral Research, University of Georgia, Athens, GA 30602 2401, USA
J Clin Psychopharmacol 26:S13-9. 2006..Preliminary data suggest that the early adoption of acamprosate is following a similar pattern. Recommendations for addressing challenges to the diffusion of pharmacotherapies for alcohol dependence are presented...
- The BRENDA model: integrating psychosocial treatment and pharmacotherapy for the treatment of alcohol use disordersAron N Starosta
University of Pennsylvania, PA 19104, USA
J Psychiatr Pract 12:80-9. 2006..This paper describes these components and discusses how the empirical support for each component is linked to the enhancement of medication compliance and the improvement of treatment outcomes...
- [Maintaining abstinence after alcohol detoxification]Philippe Batel
Traitement ambulatoire des maladies de l alcool, Hopital Beaujon, Clichy
Rev Prat 56:1100-6. 2006....
- Prescription procedures in medication for relapse prevention after inpatient treatment for alcohol use disorders in SwitzerlandCaroline Buri
University Hospital of Psychiatry Bern, Bolligenstrasse 111, 3000 Bern 60, Switzerland
Alcohol Alcohol 42:333-9. 2007..There remains, however, a paucity of studies with sufficient external validity in which the effectiveness of pharmacotherapy in clinical practice is investigated. This study aimed to make a contribution to close this gap in research...
- Results from two pharmacotherapy trials show alcoholic smokers were more severely alcohol dependent but less prone to relapse than alcoholic non-smokersLutz G Schmidt
Department of Psychiatry, Johannes Gutenberg University Mainz, Untere Zahlbacher Str 8, 55131 Mainz, Germany
Alcohol Alcohol 42:241-6. 2007..To assess the role of smoking on treatment outcome in quitting alcoholics on the background of the priming or coping hypothesis (Rohsenow et al., 1997)...
- The efficacy of acamprosate and naltrexone in the treatment of alcohol dependence: a relative benefits analysis of randomized controlled trialsJames L Snyder
Penn State Harrisburg, Middletown, Pennsylvania 17057, USA
Am J Drug Alcohol Abuse 34:449-61. 2008..There was insufficient data available to ascertain the efficacy of naltrexone and acamprosate over prolonged periods of time, or the effectiveness of the medications relative to each other...
- Cloninger's typology and treatment outcome in alcohol-dependent subjects during pharmacotherapy with naltrexoneFalk Kiefer
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Germany
Addict Biol 13:124-9. 2008..It is discussed whether especially these subjects should be targeted for pharmacological relapse prevention treatment with naltrexone...
- New therapies for alcohol dependence open options for office-based treatmentBridget M Kuehn
- Acamprosate supports abstinence, naltrexone prevents excessive drinking: evidence from a meta-analysis with unreported outcomesSusanne Rösner
IFT, Institut für Therapieforschung, Munich, Germany
J Psychopharmacol 22:11-23. 2008..Benefits in the treatment of alcohol dependence might be optimized by matching the efficacy profiles of specific antidipsotropics with the motivational status of alcohol-dependent patients...
- [Alcohol dependence: diagnosis and treatment]P Perney
Service d Addictologie, CHU Caremeau, 30029 Nimes Cedex 9, France
Rev Med Interne 29:297-304. 2008..5 million patients in France. A review about alcohol dependence is warranted, not only as prevalence of this disease is high, but also because of recent significant improvement in caring for these patients...
- From the neurobiologic basis of alcohol dependency to pharmacologic treatment strategies: bridging the knowledge gapChristopher W Shea
Fr Martin s Ashley, Havre de Grace, Maryland 21078, USA
South Med J 101:179-85. 2008..Pharmacotherapy represents a valuable component of treatment and should be combined with psychosocial and behavioral interventions to address the multifactorial nature of AD in individuals with this disease...
- The effect of naltrexone and acamprosate on cue-induced craving, autonomic nervous system and neuroendocrine reactions to alcohol-related cues in alcoholicsWendy Ooteman
Amsterdam Institute for Addiction Research, Amsterdam, The Netherlands
Eur Neuropsychopharmacol 17:558-66. 2007..It is hypothesized that naltrexone exerts its effects primarily on cue-induced craving and neuroendocrine cue reactivity, whereas acamprosate exerts its effect primarily on autonomic nervous system reactions to alcohol-related cues...
- Preclinical and clinical pharmacology of alcohol dependenceSophie Tambour
Unité de Recherche en Psychologie Expérimentale et Neurosciences Cognitives URPENC, Universite de Liege, Boulevard du Rectorat 5 B32, B 4000 Liege, Belgium
Fundam Clin Pharmacol 21:9-28. 2007..These new drugs in the field of alcohol pharmacotherapy are also discussed, together with their mechanisms of action...
- Comparing treatments of alcoholism on craving and biochemical measures of alcohol consumptionstFelice Nava
Department of Addiction Medicine, Drug Abuse Unit Ser T, Hospital of Castelfranco Veneto, Via Ospedale, 18, 31033 Castelfranco Veneto Treviso, Italy
J Psychoactive Drugs 38:211-7. 2006..The maximum effects were observed in GHB-treated patients. The results of the present study suggest that GHB might act both as anticraving and cellular protector agent...
- Choosing the right medication for the treatment of alcoholismHelen M Pettinati
Department of Psychiatry, University of Pennsylvania, Treatment Research Center, 3900 Chestnut Street, Philadelphia, PA 19104 6178, USA
Curr Psychiatry Rep 8:383-8. 2006..This report reviews the latest innovations in pharmacotherapy for the treatment of alcohol dependence, focusing on FDA-approved medications presently available to the treatment community...
- Do acamprosate or naltrexone have an effect on daily drinking by reducing craving for alcohol?Kylie Richardson
Central Clinical School of Medicine, University of Sydney, NSW, Australia
Addiction 103:953-9. 2008..To explore the effect of acamprosate and naltrexone on craving and alcohol consumption in the treatment of alcohol dependence...
- Extended-release intramuscular naltrexone: a viewpoint by Henry R KranzlerHenry R Kranzler
University of Connecticut School of Medicine, Farmington, CT, USA
Drugs 66:1753-4. 2006
- Naltrexone and disulfiram in patients with alcohol dependence and comorbid post-traumatic stress disorderIsmene L Petrakis
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
Biol Psychiatry 60:777-83. 2006....
- Which treatment for alcohol dependence: naltrexone, acamprosate and/or behavioural intervention?Sheila A Doggrell
School of Science, Faculty of Education, Health and Science, Charles Darwin University, Darwin, Northern Territory 0909, Australia
Expert Opin Pharmacother 7:2169-73. 2006..In COMBINE, this percentage was high in the group having medical management and placebo pills, and naltrexone or additional behavioural therapy only had modest additional effects...
- [Neurobiological mechanisms and pharmacological treatment options for alcohol craving]T Hillemacher
Psychiatrische und Psychotherapeutische Klinik, Universitatsklinikum Erlangen, Germany
Fortschr Neurol Psychiatr 75:26-32. 2007..Besides, there are several promising candidate substances. Current investigations focus on a differentiated pharmacotherapy of alcohol dependence, including psychological and genetic factors...
- New pharmacological approaches for the treatment of alcoholismMichael Soyka
Private Hospital Meiringen, P O Box 612, CH 3860 Meiringen, Switzerland
Expert Opin Pharmacother 7:2341-53. 2006..Tricyclics have been found to be more effective than serotonin reuptake inhibitors in improving depressive symptoms in these patients...
- [Pharmacological relapse prevention in alcohol and tobacco dependence]A Diehl
Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, J5, 68159, Mannheim, Germany
Internist (Berl) 48:79-84, 86-8. 2007..A specific application of these substances will optimise the outcome for alcohol and tobacco dependent patients...
- [Pharmacological review of alcoholic dependence treatment]Leandro Oural
Hospital Alvarez
Vertex 19:512-21. 2008..We will also refer to topiramate, which is being studied for this indication...
- Clinical characterization of use of acamprosate and naltrexone: data from an addiction center in IndiaDebasish Basu
Drug De addiction and Treatment Centre, Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Am J Addict 14:381-95. 2005..Logistic regression analysis showed that both family/social support and acamprosate appeared to contribute modestly toward explaining the variance in short-term outcome...
- Addiction medicine for the primary care physicianW H Yarborough
University of Oklahoma, College of Medicine, Tulsa Campus, Department of Internal Medicine, 4502 E. 41st Street, Tulsa, OK 74135-2512, USA
J Okla State Med Assoc 94:499-506. 2001..Finally a look at parity for addiction treatment with a discussion of the cost and the benefits to society are also outlined...
- A pharmacokinetic and pharmacodynamic drug interaction study of acamprosate and naltrexoneBarbara J Mason
Division of Substance Abuse, Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, FL, USA
Neuropsychopharmacology 27:596-606. 2002..A complete absence of negative interactions on measures of safety and cognitive function supports the absence of a contraindication to co-administration of acamprosate and naltrexone in clinical practice...
- Recent advances in the pharmacotherapy of alcoholismHugh Myrick
Alcohol Research Center, Medical University of South Carolina Department of Psychiatry and Behavioral Sciences, 67 President Street, Charleston, SC 29425, USA
Curr Psychiatry Rep 6:332-8. 2004..Data on naltrexone, acamprosate, and topiramate will be highlighted. In addition, data concerning the use of serotonin reuptake inhibitors in subtypes of alcoholism and the use of combination pharmacotherapy will be reviewed...
- Physicians' opinions about medications to treat alcoholismTami L Mark
Medstat, Washington, DC 20008, USA
Addiction 98:617-26. 2003..This paper examines physicians' opinions about and use of two alcoholism medications currently approved in the US--disulfiram and naltrexone--and one alcoholism medication--acamprosate--that might be approved...
- [Long-term treatment of alcohol dependance]Louis Philippe Fideli
Psychiatrie, CHU Louis Mourier, 178, rue des Renouillers, 92700 Colombes, France
Gastroenterol Clin Biol 26:B169-73. 2002
- Learning the language of abstinence in addiction treatment: some similarities between relapse-prevention with disulfiram, naltrexone, and other pharmacological antagonists and intensive "immersion" methods of foreign language teachingColin Brewer
The Stapleford Centre, London, United Kingdom
Subst Abus 24:157-73. 2003..Supervised or depot naltrexone acts similarly in opiate dependence. We discuss the concept of antagonist-assisted abstinence...
- Effect of the combination of naltrexone and acamprosate on alcohol intake in miceSung Gon Kim
Department of Psychiatry, School of Medicine, Pusan National University, Pusan, Korea
Psychiatry Clin Neurosci 58:30-6. 2004..When combined with naltrexone, acamprosate reduced alcohol consumption across both doses of naltrexone. This effect was sensitive to both dose and number of days of exposure to the naltrexone/acamprosate combination...
- [Drug therapy of alcohol dependence--a critical review]Mikko Salaspuro
Biomedicum Helsinki, Päihdelääketieteen tutkimusyksikkö PL 63, 00014 Helsingin yliopisto
Duodecim 119:2503-7. 2003
- Use of acamprosate and opioid antagonists in the treatment of alcohol dependence: a European perspectiveMichael Soyka
Psychiatric Hospital, University of Munich, Munich, Germany
Am J Addict 12:S69-80. 2003..Some centers suggest naltrexone not only for patients aiming for abstinence but also for patients for whom continued drinking is a therapeutic possibility or a clinical inevitability...
- AcamprosateBarbara J Mason
Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, Florida 33136, USA
Recent Dev Alcohol 16:203-15. 2003
- [The pharmacologic treatment of the alcohol dependence]Luís André Castro
Unidade de Pesquisa Clínica, Unidade de Pesquisa em Alcool e Drogas, Departamento de Psiquiatria, EMP UNIFESP, Brazil
Rev Bras Psiquiatr 26:S43-6. 2004..Ondansetron, has shown promise in the early-onset alcohol dependence but needs more extensive study. Topiramate (up to 300 mg per day) was more efficacious than placebo in the treatment of alcohol dependence...
- Pharmacologic approaches to the management of alcoholismR F Anton
Alcohol Research Center, Medical University of South Carolina, Charleston 29425, USA
J Clin Psychiatry 62:11-7. 2001..This article will discuss animal and clinical studies of the opioid antagonists (primarily naltrexone), acamprosate, and disulfiram. The side effects and treatment recommendations for each drug will also be reviewed...
- Pharmacological mechanisms of naltrexone and acamprosate in the prevention of relapse in alcohol dependenceJohn Littleton
Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, KY 40546 0236, USA
Am J Addict 12:S3-11. 2003....
- Pharmacological relapse prevention in alcohol dependence: from animal models to clinical trialsJ A Boening
Department of Psychiatry, Addiction Medicine, University of Wuerzburg, Germany
Alcohol Clin Exp Res 25:127S-131S. 2001..Wiesbeck; and (6) Methodology and behavioral therapy of the U.S. acamprosate study, by Barbara J. Mason...
- Increasing leptin precedes craving and relapse during pharmacological abstinence maintenance treatment of alcoholismFalk Kiefer
Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, J5, 68159 Mannheim, Germany
J Psychiatr Res 39:545-51. 2005..Moreover, there are hints for an interaction between pharmacological anti-craving treatment, plasma concentration of leptin, and abstinence duration...
- Naltrexone versus acamprosate: one year follow-up of alcohol dependence treatmentG Rubio
Psychiatric Service, 12 de Octubre University Hospital, Madrid, Spain
Alcohol Alcohol 36:419-25. 2001..There were non-significant trends for the naltrexone group to comply better with medication, to stay in the study longer, and to show greater improvement over baseline in serum GGT...
- One-year follow-up of disulfiram and psychotherapy for cocaine-alcohol users: sustained effects of treatmentK M Carroll
Department of Psychiatry, Yale University School of Medicine, USA
Addiction 95:1335-49. 2000..To evaluate outcomes 1 year after cessation of treatment for cocaine- and alcohol-dependent individuals...
- Disulfiram, a drug widely used to control alcoholism, suppresses the self-renewal of glioblastoma and over-rides resistance to temozolomideJoanna Triscott
Department of Pediatrics, University of British Columbia, Vancouver, BC
Oncotarget 3:1112-23. 2012..Likewise, PLK1 inhibition with siRNA, or small molecules (BI-2536 or BI-6727) blocked growth of TMZ resistant cells. Our studies suggest that DSF has the potential to be repurposed for treatment of refractory GBM...
- Monitoring relapse drinking during disulfiram therapy by assay of urinary 5-hydroxytryptopholA Helander
Karolinska Institute, Department of Clinical Neuroscience, St Gorans Hospital, Stockholm, Sweden
Alcohol Clin Exp Res 22:111-4. 1998..It is also suggested that an individual dose-titration regimen, whereby the disulfiram dose is raised gradually until 5HTOL/5HIAA testing indicates sobriety, will improve therapeutic effectiveness...
- Preliminary findings on the use of metadoxine for the treatment of alcohol dependence and alcoholic liver diseaseLorenzo Leggio
Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island 02912, USA
Hum Psychopharmacol 26:554-9. 2011..Metadoxine is approved in Europe for alcohol intoxication and is also indicated for alcoholic liver disease (ALD). This study aims to investigate the use of metadoxine as a potential pharmacotherapy for alcohol dependence (AD)...
Research Grants62
- Maximizing CBT's Efficacy with Medication & CMKathleen Carroll; Fiscal Year: 2009..Variables assessing theoretical mechanisms of action will be assessed monthly during treatment. ..
- Planning for a CTSA Application at the University of ConnecticutJudith Fifield; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Matching 5-HT Genotypes to Serotonergic Medications for AlcoholismGEORGE ANTHONY KENNA; Fiscal Year: 2010....
- Sertraline Pharmacotherapy for Alcoholism SubtypesHenry Kranzler; Fiscal Year: 2007..abstract_text> ..
- GENETICS OF COCAINE DEPENDENCEHENRY RICHARD KRANZLER; Fiscal Year: 2010..Knowledge of the gene variants will help to identify people at greatest risk of developing the disorder, thereby improving prevention efforts. ..
- CANNABIS AND SCHIZOPHRENIA: CLOZAPINE VS RISPERIDONEAlan Green; Fiscal Year: 2005..If the results of this study confirm the preliminary data, they could suggest a new use for CLOZ, one that could have important public health implications. ..
- Efficacy and Safety of Baclofen for Alcohol DependenceJames Garbutt; Fiscal Year: 2006..Several studies also have found that baclofen reduces self-reported anxiety and craving; thus, the proposed study will assess baclofen's ability to reduce these symptoms as well. ..
- BEHAVIORAL SUPPORT WITH PHARMACOTHERAPY FOR ALCOHOLICSHelen Pettinati; Fiscal Year: 2004..However, each study site has provided site-specific information on the budget, budget justifications, listing of key personnel, consultant/consortium agreements, and human subjects sections of their respective proposals. ..
- Clozapine, cannabis and first episode schizophreniaAlan Green; Fiscal Year: 2003....
- Modifying Group Therapy for Bipolar AbusersRoger Weiss; Fiscal Year: 2006..If warranted by the results, effect sizes from the proposed study will be used to help in the preparation of a larger-scale subsequent Stage II study. ..
- Gabapentin as an Adjunct to Naltrexone for AlcoholismRaymond Anton; Fiscal Year: 2006..This evaluation of a novel treatment will allow us to better understand combined pharmacotherapy and develop a new paradigm for medications development for alcoholism. ..
- POLYDRUG ABUSE-IMAGING AND BEHAVIORScott Lukas; Fiscal Year: 2006..Results of these studies may also reveal why cue-induced craving has not been a good predictor of relapse as there may be significant cross generalization among the cues that can trigger relapse in successfully treated patients. ..
- ALCOHOLISM AND SCHIZOPHRENIA--EFFECTS OF CLOZAPINEAlan Green; Fiscal Year: 2001....
- Cocaine Withdrawal and Pharmacotherapy ResponseMehmet Sofuoglu; Fiscal Year: 2010..This proposal, by testing the efficacy of carvedilol and investigating the influence of withdrawal severity on carvedilol's efficacy, may result in development of more effective treatments for cocaine addiction. ..
- PHARMACOLOGICAL AND BEHAVIORAL INDICES OF DRUG ABUSEScott Lukas; Fiscal Year: 2008..abstract_text> ..
- Topiramate for alcohol and cocaine dependenceKyle Kampman; Fiscal Year: 2008..abstract_text> ..
- Cannabis Dependence: Imaging and Medication DevelopmentScott Lukas; Fiscal Year: 2005..abstract_text> ..
- MEDICATION DEVELOPMENT FOR COCAINE ABUSE--CDP CHOLINEScott Lukas; Fiscal Year: 2004....
- Cannabis and Schizophrenia: Self-Medication and Agonist Treatment?Alan I Green; Fiscal Year: 2010..Finding medications that may be able to limit cannabis use and thereby reduce adverse outcomes in patients with schizophrenia is of great public health importance. ..
- RELAPSE PREVENTION GROUP FOR BIPOLAR SUBSTANCE ABUSERSRoger Weiss; Fiscal Year: 2001....
- Cannabis & Schizophrenia: fMRI Reward Circuit BiomakerAlan Green; Fiscal Year: 2005..Finding new medications, safer than CLOZ, that may be able to limit cannabis use In patients with SCHIZ is thus of considerable public health relevance. ..
- Three Methods for Costing Methadone Treatment ServicesGARY ZARKIN; Fiscal Year: 2006..abstract_text> ..
- SERTRALINE FOR ALCOHOL DEPENDENCE AND DEPRESSIONHelen Pettinati; Fiscal Year: 2003..Overall, this project will determine if combining pharmacotherapies results in a better response in comorbidly depressed alcoholics than either medication alone or placebo. ..
- Antipsychotics and Alcohol Drinking in RodentsAlan Green; Fiscal Year: 2005..The long-term goal of our research is to create better treatments for alcoholism in patients with SCH (and possibly even in those without SCH). ..
- TRAINING IN FUNCTIONAL IMAGING AND ALCOHOL WITHDRAWALDONALD MYRICK; Fiscal Year: 2004....
- COST EFFECTIVENESS OF ALCOHOL TREATMENTGARY ZARKIN; Fiscal Year: 2004..abstract_text> ..
- Modeling Benefits and Costs of Prison-Based Substance Abuse TreatmentGARY ZARKIN; Fiscal Year: 2009..2005a). Results will help policy makers make better judgments about the allocation of funding to prison-based drug treatment resources. ..
- GABA Medications for Tobacco AddictionMehmet Sofuoglu; Fiscal Year: 2009..The findings of this study will provide valuable information to develop new pharmacotherapies for smoking cessation. ..
- Progestrone and the Effects of NicotineMehmet Sofuoglu; Fiscal Year: 2006..By characterizing the progesterone effects on nicotine dependence, this study may provide a better understanding of the mechanisms which mediate the sex and menstrual cycle phase effects on nicotine dependence. ..
- LEAD: ATTENTION, IMPULSIVITY, AND DOPAMINESTEPHEN KIEFER; Fiscal Year: 2002..abstract_text> ..
- Alcohol Dependence in General Medical SettingsScott Stewart; Fiscal Year: 2008....
- AMLODIPINE TREATMENT FOR COCAINE DEPENDENCERobert Malcolm; Fiscal Year: 2001....
- Alcohol Screening and Brief Intervention in an EAPJeremy Bray; Fiscal Year: 2008..Taken together, our findings will provide researchers, EAP professionals, employers, and policy makers with a complete picture of the costs, benefits, feasibility, and sustainability of an SBI program within an EAP. ..
- Innovative Approaches to Modeling Alcohol RelapseG Marlatt; Fiscal Year: 2004..The abundance of treatment outcome data for addictive behaviors makes the proposed research an important and cost-effective contribution to the advancement of our understanding of the relapse process. ..
- Cognitive Behavioral Treatment of PTSD in SMI ClientsKim T Mueser; Fiscal Year: 2010..The results of this research will bring the field one step closer to having an evidence-based practice for trauma and PTSD in clients with SMI. ..
- Effectiveness of Alcohol Interventions Among TB Patients in Tomsk, RussiaSonya Shin; Fiscal Year: 2008..Finally, we have a diverse interdisciplinary team that has been able to formulate an integrated biosocial and culturally-appropriate approach to treating AUDs in this population. [unreadable] [unreadable] [unreadable]..
- Research Center on Managed Care and Drug Abuse TreatmentConstance Horgan; Fiscal Year: 2008..This pilot will explore the feasibility for a large-scale study of the incremental impact of adding a substance abuse treatment parity benefit to private health insurance in California. ..
- NEUROTROPHINS AND REPEATED COCAINERobert Pierce; Fiscal Year: 2002....
- Colorectal Cancer Screening in Primary Care PracticeSteven Ornstein; Fiscal Year: 2009..A mixed-method process evaluation will also be conducted to assess the adoption of PPRNet-TRIP within participating practices. ..
- FACTORS AFFECTING USE OF MEDICATION TO TREAT ALCOHOLISMTAMI MARK; Fiscal Year: 2001..We propose to collect this information through experts panels and a national survey of physicians specialized in treating substance abuse. ..
- INTERVENTION FOR ADOLESCENT INDIAN DRINKINGG Marlatt; Fiscal Year: 2001..115 outpatients and 80 continuing care patients will participate in each of the two treatment conditions. ..
- CBT and Modafinil for Cocaine AddictionRobert Malcolm; Fiscal Year: 2009....
- Neurobehavioral Assessment of Ethanol Seeking and IntakeCristine Czachowski; Fiscal Year: 2005....
- Efficacy of Mindfulness-Based Relapse PreventionG Marlatt; Fiscal Year: 2007..unreadable] [unreadable]..
- Home Base Treatment for Drug Use in Early AdolescentsOscar Bukstein; Fiscal Year: 2005..These interventions are expected to improve not only substance abuse outcomes, but a range of impairments and symptoms associated with the DBDs and high risk for the early onset type of substance use disorder. ..
- Adoption of Pharmacotherapy in Alcoholism TreatmentPeter Miller; Fiscal Year: 2005..abstract_text> ..
- Form/function of Extended Amygdala/Accumbens Shell:CRFDANIEL ZAHM; Fiscal Year: 2005....
- FAMILY INTERVENTION FOR SMI AND SUBSTANCE USE DISORDERSKim Mueser; Fiscal Year: 2005..Improvements in these areas may the have long-term benefit of maintaining family involvement with dually diagnosed clients, thereby reducing housing instability and homelessness. ..
- Potential anti-relapse drugs: a plant genomics approachJohn Littleton; Fiscal Year: 2004..In phase 3, potential products will be commercialized with a partner specializing in pharmaceutical natural products. ..
- PHARMACOLOGICAL AND BEHAVIORAL TREATMENT WITH ALCOHOLICSDennis Donovan; Fiscal Year: 2004..However, each study site has provided site-specific information on the budget, budget justifications, listing of key personnel, consultant/consortium agreements, and human subjects sections of their respective proposals. ..
- Increasing Treatment Adherence in Co-Occurring DisordersMichael Pantalon; Fiscal Year: 2006..Secondary outcomes include reductions in depressive symptomatology and rates of re-hospitalization. ..
- MEDICATION/PSYCHOTHERAPY TAILORED TO PATIENT RESOURCESRobert Swift; Fiscal Year: 2004..However, each study site has provided site-specific information on the budget, budget justifications, listing of key personnel, consultant/consortium agreements, and human subjects sections of their respective proposals. ..
- LPH to VTA Neurotensin: Actions and Cocaine EffectsDANIEL ZAHM; Fiscal Year: 2004..The data may lead to better, more selective therapeutic approaches to prevention of psychostimulant sensitization, which is thought play a significant role in destructive drug seeking behaviors. ..
- Device for Acamprosate Transcutaneous Delivery to Reduce Alcohol Consumption.Robert Swift; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Novel estrogen receptor ligands from plant genomicsJohn Littleton; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Clinical-Genetic Variation in GABA /Alcohol SensitivityJohn Roache; Fiscal Year: 2004....
- Facilitating Alcohol Screening of Hypertensive PatientsPeter Miller; Fiscal Year: 2006..Such screening and intervention should improve blood pressure control in many of these patients and, in turn, reduce risk of chronic disease and death. ..
- Gabapentin for Cannabis Withdrawal and UseBarbara Mason; Fiscal Year: 2007..unreadable] [unreadable]..
- Application of plant genomics to alcoholic brain damageJohn Littleton; Fiscal Year: 2006..unreadable] [unreadable]..
- DEVELOPMENT OF SCREENS FOR DRUGS IN ALCOHOL DEPENDENCEJohn Littleton; Fiscal Year: 2007..abstract_text> ..
- Alcohol Phenotype Development in American SamoaRobert Swift; Fiscal Year: 2008..We will also utilize behavioral testing [unreadable] to assess the potential endophenotypes of sweet preference, risk taking, and cue-induced alcohol craving in the participants. [unreadable] [unreadable] [unreadable]..


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My Nonprofit Reviews
Review for Mercy Medical Angels, Virginia Beach, VA, USA
I have been associated with Mercy Medical Airlift for over 20 years as a friend, donor, volunteer and Board member. I have personally witnessed the providing of transportaion and related help to thousands of people needing the care and compassion of others in time of urgent medical need. When I read letters received from the people helped and hear personal testimonies, I know without a doubt that we are serving in a worthwhile, God-honoring and life-changing way. Our service to military veterans is special and helps to say thank-you in an encouraging way to those who have served our country. Having lost a grand-daughter to cancer, I know the importance of getting someone with serious medical issues to a doctor and/or medical facility quickly. I encourage you to support Mercy Medicall Airlift in your prayers and with your financial and volunteer support.
More Feedback
Will you volunteer or donate to this organization beyond what is required of board members?
How much of an impact do you think this organization has?
When was your last experience with this nonprofit?

subset: commoncrawl


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Watch: Priyanka Chopra, Anushka Sharma groove to 'Girls Like To Swing'
Makers of 'Dil Dhadakne Do' have released another song from the film, and this time the video features Priyanka Chopra and Anushka Sharma shaking a leg to 'Girls Like To Swing'.
Watch the foot-tapping number 'Girls Like To Swing':
The two Bollywood divas up the glam quotient in the peppy number. Ranveer Singh and Rahul Bose can be seen enjoying the performance put up by Priyanka and Anushka in the song.
The ever-entertaining Ranveer Singh took to Twitter to share his thoughts on the song. He tweeted, "The truth is..I wanted to Swing with the girls too..But Zoya wouldn't let me! ;)"
Ranveer Singh shared this image while tweeting his thoughts about the song 'Girls Like To Swing'. Picture courtesy: Ranveer's Twitter account @RanveerOfficial
Makers of 'Dil Dhadakne Do' had earlier released a song titled 'Pehli Baar' where Ranveer and Anushka share a sizzling chemistry and flaunt their moves in the high-octane dance duet. To watch the video, click here.
The ensemble cast also features Farhan Akhtar, Anil Kapoor and Shefali Shah in this film revolving around a dysfunctional Punjabi family on a cruise trip.
'Dil Dhadakne Do' is slated to release on June 5.


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Mother Feather
Currently finishing work on their sophomore album with Grammy-nominated producer Joshua Valleau, Mother Feather has launched a new lyric video for the track 'Egyptology.'Read More
Fates Warning
On January 12th, Metal Blade Records will re-issue two of Fates Warning's fan-favorite albums, 'Perfect Symmetry' (1989) and 'Parallels' (1991), as part of the label's 'Originals series'.Read More
Cannibal Corpse
Cannibal Corpse recently released their new album, 'Red Before Black', via Metal Blade Records; for their efforts, the band has now entered the international charts!Read More
Good Tiger
Today, rock quintet Good Tiger is thrilled to share their brand new video, 'Grip Shoes', which can be viewed now. The track comes from the band's forthcoming sophomore album, 'We Will All Be Gone'.Read More
Cattle Decapitation
After recently releasing a bass play-through for 'Clandestine Ways (Krokodil Rot)', Cattle Decapitation is now launching a guitar play-through for 'Circo Inhumanitas', by the band's own Josh Elmore.Read More
New Releases
Upcoming Releases
Latest News
DragonForce reveals details for new album
- February 8th, 2017 – International metal superstars DragonForce have...Read More
Six Feet Under launches new track, "The Separation of Flesh from Bone", online
- February 8th, 2017 – On February 24th, Six Feet Under returns with...Read More
Evocation launches behind-the-scenes video for new album 'The Shadow Archetype'
- February 8th, 2017 – On March 10th, Evocation will celebrate their...Read More
GWAR B-Q Postponed Until 2018
- February 8th, 2017 – New Album In Progress – Heavy Touring in...Read More
Byzantine launches PledgeMusic campaign for new album, 'The Cicada Tree'
- February 7th, 2017 – The name Byzantine is synonymous with a band...Read More
The Ocean launches live video for "Rhyacian"
- February 7th, 2017 – Germany's premier post-metal act The Ocean...Read More
AntropomorphiA launches new single, "Crown ov the Dead"
- February 6th, 2017 – On February 24th, AntropomorphiA returns with...Read More
Nova Collective launches live performance video for first single, "Dancing Machines"
- February 2nd, 2017 – Featuring members of Between the Buried and Me,...Read More


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Greetings! My name is Andrew, and I work in the Forefront Server Security (FSS) test group in Long Island, New York. If you're like me (and for your sake, I hope you're not) you spend a lot of your time reading the Forefront Security for Exchange Server and Anti-virus/Anti-spam Microsoft TechNet forums. (You don't read the Microsoft TechNet forums, you say? Shame on you. They really are a great resource for information on FSS, Exchange, Office, and just about everything else Microsoft. If you have a technical question, post it on the forums and soon an army of über-cyber-geeks, much like myself, will answer it for you.)
Anyway, while reading the forums after playing D&D one Saturday night, I noticed there is quite a bit of confusion concerning Spam filtering in Forefront and Antigen. How do I configure Forefront to stop Spam? Is Spam filtering part of Forefront and Antigen, or is it part of Exchange? Is Anti-Spam executed on the Edge server or the Mailbox server? And just what is the story with the Hub server?
The answer depends on which version of Exchange you are running.
Microsoft Antigen, which protects your Exchange 2000 and Exchange 2003 servers, provides robust anti-spam capabilities. On these servers, your Anti-Spam settings will be found in the Antigen UI, not in the Exchange UI. Just keep in mind that if you want to take advantage of the Anti-Spam features of Antigen, you will need to download Antigen for Exchange with Antigen Spam Manager from the Messaging Security Suite. If you do not download this version, when you open the Antigen Administrator you will see the Anti-Spam icon display for a second and then disappear.
If you are running Exchange Server 2007, you will find that Microsoft Forefront Security does not provide Anti-Spam features. Why is Spam filtering included in Antigen, but not in Forefront, you ask? That is because Anti-Spam protection is provided by Exchange 2007, so it would be redundant to include these features in Forefront as well. Although Spam filtering has moved from Forefront to Exchange, Forefront does still provide keyword filtering, which identifies unwanted e-mail messages by analyzing the contents of the message body. By creating keyword lists, messages can be filtered based on a variety of words, phrases, and/or sentences.
It is important to remember that Anti-Spam is enabled by default on Exchange 2007 Edge servers, while it is disabled by default on Hub servers. If you do not have an Edge server, and you want to enable Spam filtering on your Hub server, you may do so by running the Anti-Spam add-on script. First, launch the Exchange Management Shell. In the Scripts folder, you will find the install-antispamagents PowerShell script, which, appropriately, installs the Anti-Spam agents. After running this command, you will need to restart your transport service and Exchange Management Console. You will then see the Anti-Spam features displayed in the Exchange UI. Finally, it should be noted that although you do not need a Forefront license to access the Exchange 2007 Anti-Spam features, Forefront does include the right-to-use for the enhanced anti-spam features of Exchange.
And that's all there is to it!
Now, if you've managed to stay awake and read this far (1 in 50 do!) you probably have some questions. Please post any questions you may have either here on the TechNet forums. There is a cyber-geek out there somewhere – perhaps myself – waiting to answer it for you.


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Action suspends shares
Could there be an acquisition announcement waiting in the wings..?
Action Computer Supplies suspended its shares yesterday morning after a fall in price, prompting speculation that an announcement concerning the company's impending sale was in the offing. The PC reseller asked that trading in its shares be suspended "pending an announcement." Shares were frozen at just over £2.70, against a mid-month high of £3. A company representative said they were awaiting a statement from Action, but could not say if it would be made this week. In May, US giant Insight confirmed it had agreed a $150 million bid to buy Action. The all share offer worked out at 260.7 pence per Action share. ®


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HALIFAX, Nova Scotia, April 10 (UPI) -- The mother of a teenage girl in Nova Scotia who committed suicide said her daughter was raped and photographed by four boys before her death.
Rehtaeh Parsons, 17, died Sunday in a hospital after attempting suicide a few days earlier.
Four boys allegedly raped Rehtaeh when she was 15, her mother told the Canadian Broadcasting Corp.
After a year of investigating, police told Parsons there was not enough evidence to file charges, and the photographs of the act did not indicate a criminal issue.
Parsons said other students began bullying and tormenting her daughter.
"She was never left alone. Her friends turned against her, people harassed her, boys she didn't know started texting her and Facebooking asking her to have sex with them since she had had sex with their friends. It just never stopped," said Parsons.
Many people have expressed outrage that more had not been done to help Rehtaeh, CBC said.
An online petition demanding an inquiry into the police investigation now has more than 2,000 signatures.
Nova Scotia's Justice Minister said Tuesday he was asking his office to look into what actions they could take on the case.


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Multiple sclerosis is a central nervous system disease characterized by an autoimmune mediated inflammatory demyelination, marked by lesions separated by time and space. It is a disease that results in severe disability due to the wide range of comorbid problems that occur as the disease progresses.
The two major functions of the bladder are storage and emptying of urine. Bladder control is complex and requires coordination of function of the cerebral cortex, peripheral nervous system, and pontine and sacral micturition centers. Demyelinating lesions may impair both sensory and motor function.
Patients with multiple sclerosis may often have motor impairment in their lower extremities, and this impairment may be accompanied by bladder sphincter dysfunction. As the lesions of multiple sclerosis progress to demyelination of the sacral spinal nerves, patients may experience neurogenic bladder and the sequelae, which include infections, renal calculi, renal failure, and vesicoureteral reflux.
Patients commonly complain of urinary urgency resulting from uncontrolled contraction of the detrusor muscle as a result of a suprasegmental lesion. This can produce bladder spasms, urgency, frequency, and incontinence. Hyperactivity of the bladder sphincter may impair the patient's ability to empty the bladder completely. A lack of coordination between the actions of the detrusor and sphincter, known as detrusor sphincter dyssynergia, may lead to contractions of the bladder against a closed sphincter, elevating pressure within the bladder and resulting in vesicoureteral reflux.
With disease progression and increased involvement of the sacral segments of the spinal cord, patients may experience bladder hypoactivity, including decreased urinary flow, interruption of micturition, and incomplete voiding. The resulting atonic bladder becomes dilated and empties by overflow as a result of loss of the sensation of fullness. At the same time, sensory deficits in the sacral dermatomes are not uncommon, nor is hypesthesia in urethral, anal, and genital regions.
Bladder symptoms self-reported in one study of 297 patients with multiple sclerosis did not correlate with post-micturition residual bladder volume, and the authors of that study suggest ultrasound scanning for residual urinary volume in all patients with multiple sclerosis, whether or not they have subject urinary symptoms. 1
Other clinicians recommend post-void residual scanning in patients who are symptomatic before the initiation of therapy with an anticholinergic medication.2
As with any management strategy for bladder problems associated with lesions of the central nervous system, the goal of treatment is to avoid complications, including retention and infection, and to enable the patient to minimize episodes of incontinence. Before proceeding with treatment of urinary symptoms in patients with multiple sclerosis, infection and other causes of urinary urgency and incontinence should be ruled out. Urodynamic studies may be in order to assess the pathophysiology of any urinary tract dysfunction.3
Treatment Options
Treatment strategies for bladder dysfunction in patients with MS should target the suppression of urgency and the continued effectiveness of urinary drainage. A stepwise approach to treatment of the problems associated with sphincter dysfunction includes fluid restriction to less than 2 liters per day, coupled with timed voiding. Medical therapies have long consisted primarily of anticholinergic and antimuscarinic drugs.4
Oxybutynin is the first-line medication for bladder dysfunction, given in doses of 2.5 to 5 milligrams one to three times daily. It may also be given as an extended-release preparation or as a transdermal patch. Tolterodine is another first-line anticholinergic therapy, and is also available in a long-term preparation.
Clean technique intermittent catheterization can be performed at regular intervals to achieve a bladder volume of less than 500 cc of urine. This technique has a lower rate of infection when compared to long-term catheterization. However, voluntary voiding in response to a sensation of fullness is encouraged.
Botulinum toxin injection is one treatment option for neurogenic bladder detrusor overactivity in patients for whom anticholinergic or antimuscarinic therapy is intolerable or ineffective. Several trials that have included patients with MS or spinal cord injury utilizing onabotulinumtoxinA injections into the detrusor muscle have shown that this therapy is more effective than placebo for reduction of urinary incontinence and for improvement in measures of quality of life.5 A side effect may be urinary retention, requiring clean technique intermittent catheterization.
Despite these therapeutic measures, there will still be intermittent urinary incontinence, and condom catheters or adult diapers are necessary short-term interventions.


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GAZA CITY, Gaza Strip (AP) _ An Israeli warplane fired a missile that flattened a Gaza City apartment building early today, killing a Hamas leader at the top of Israel's most wanted list and at least 14 other Palestinians, including nine children, Palestinians said. The air strike came as Palestinian and Israeli political leaders were trying to relieve tensions in the West Bank. Hamas said it will take revenge. The attack killed Salah Shehadeh, 48, a founder and the top commander of Hamas' military wing, the group said.
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text:
The Brewery
A gathering place for sports analysis and opinion with Seattle Times sports columnist Jerry Brewer.
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Dynamic Duel podcast: Sonics Blame Game
Posted by Jerry Brewer
In this podcast, Danny O'Neil and I discuss the Sonics/Thunder, Seattle/Oklahoma City feud one more time, explain why the thinking behind why we wrote two very different columns on the subject in recent days and provide the definitive list, including percentages, of who to blame for Seattle's NBA-less predicament.
Howard Schultz: 66.6 (hmm, I wonder why that number?) percent
Local and state politicos: 10.5 percent
David Stern: 10.4 percent
Clay Bennett: 10 percent
Seattleites who didn't support efforts to keep the Sonics: 2.5 percent
Also included in this episode: Will Michael Pineda ever be better than Felix Hernandez? Do the NBA rules favor point guards too much now? Which player will be the next one ousted on "Mariners Survivor?" And in Last Call, a discussion of Mariners first baseman Justin Smoak's hot start.
Click here to listen to the podcast in your preferred media player.
Here's the link to subscribe to The Dynamic Duel on iTunes. This week's episode will be up soon on there.
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Feb 3 - 9:47 AM Wishing Steve Kelley the best in retirement
Jan 25 - 4:31 PM Jerry Brewer hits the red carpet at Sports Star of the Year


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My Nonprofit Reviews
Review for Kids for Peace, Carlsbad, CA, USA
Kids for Peace is a unique organization that teaches children about peace and how to create it. I serve as a Board Member of Kids for Peace because we need peace in this world. I see that the next generation is strong, intelligent, and creative. They can make it happen. Working toward this goal is constant and ever-evolving. There are so many things that we can do as individuals, yet as a group peace spreads exponentially. "Let there be peace... YEAH!"
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Shares of United Technologies Corp. (UTX - Free Report) scaled a new 52-week high of $120.49 on April 4, 2014, before closing the trading session a little lower at $118.18. This translated to a healthy year-over-year return of 26.1%.
This Zacks Rank #3 (Hold) stock has witnessed a roller-coaster ride since the beginning of the year and is currently trading at a forward P/E of 17.3x. With long-term growth expectations of 11.1%, United Technologies expects organic growth and order volume to continue to accelerate in 2014 and beyond.
Growth Drivers
United Technologies is flourishing on lucrative contracts for jet engine replacements and fresh demand for helicopters in the public services sector. It is investing heavily in technological innovation to come up with new products to fend competition.
While Sikorsky, a unit of United Technologies, is Pentagon's leading helicopter supplier, Pratt & Whitney is a dominant player in the worldwide helicopter market and is recognized for outstanding reliability, durability and exceptional operating economics.
Furthermore, United Technologies serves various end-markets such as aerospace, defense and commercial construction, which move according to their own cycles. This business mix and diversification allow the company to remain profitable even during tough economic times, delivering consistent earnings and dividend growth. The company has an experienced management team that is likely to capitalize on the continued global economic recovery and deliver sustainable earnings growth in 2014.
United Technologies also has a strong balance sheet with adequate liquidity to fuel its growth engine. The company generates strong free cash flow. The cash flow allows management to invest in product innovations, acquisitions and business development. The company continues to invest in innovative new products delivering value to its customers and securing orders that are likely to drive top-line growth in the future.
Other Stocks to Consider
Stocks in the industry that are worth reckoning include CLARCOR Inc. , Crane Co. (CR - Free Report) and 3M Company (MMM - Free Report) , each carrying a Zacks Rank #2 (Buy).
In-Depth Zacks Research for the Tickers Above
Normally $25 each - click below to receive one report FREE:
3M Company (MMM) - free report >>
United Technologies Corporation (UTX) - free report >>


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Rhapsody Now Available on Smart TVs
As part of its strategy to be everywhere its members are listening to music, Rhapsody said on Wednesday that it is now available on LG, Panasonic and Samsung Smart TVs. The Rhapsody TV apps are optimized to facilitate convenient, fast playback with a "visually rich" interface that maximizes HD displays.
"Our customers tell us they use Rhapsody differently on their television than they do on their PC, smartphone or tablets," said Paul Springer, SVP product and design, Rhapsody. "So, we prioritized features such as radio stations, favorite tracks, editorial and customer-curated playlists as well as new releases and recommendations. With Rhapsody for your Smart TV, you get the right music, right now, right in your living room."
Rhapsody will also be available on Sharp Smart TVs within the coming months. Microsoft also recently announced that the Rhapsody music service will be part of Xbox Live, launching later this year, the company said.
The news follows a recent update to the Android version which now allows users to download individual albums and tracks. This is ideal for consumers who want to listen to their favorite artists on the go, but don't want to eat up their mobile service's monthly data allowance. Plus this ensures that music isn't interrupted when data streams are suddenly throttled or dropped completely.
"Along with the ability to download those albums and tracks, you advanced users will be able to decide where to put them!" said Rhapsody Android lead engineer Randy Kruzan. "We looked at what we could do quickly as we wrapped up on the album and track download work to fulfill this request, so you may find it a little sparse, but we'll work to make it more robust."
Rhapsody currently offers two subscription models: Premier for $9.99 per month and Premier Plus for $14.99 per month. Rhapsody does not provide a free version like MOG and Spotify, but does offer a free trial. The company is also still offering a summer special allowing users to pay $5 per month for three months.
With the cheaper Premier subscription model, users can play millions of full-length tracks, without limits, transfer subscription tracks to one authorized, Rhapsody-compatible portable device, or use the Rhapsody application for iPhone or Android to put the entire Rhapsody catalog on a smartphone. Rhapsody Premier Plus is a bit more robust, offering everything Rhapsody Premier does, but users can also load and reload up to three portable MP3 players with music from Rhapsody's catalog.
Rhapsody originally launched in 2001 as one of the first streaming on-demand music subscription services, and became part of RealNetworks' acquisition of Listen.com in 2003. However the service officially declared its independence from RealNetworks in 2010, and has since scooped up former rival Napster. The Napster acquisition supposedly included handing over a minority stake in Rhapsody to Best Buy who acquired Napster back in 2008 for $121 million.


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Nintendo 3DS
You're browsing the GameFAQs Message Boards as a guest. Sign Up for free (or Log In if you already have an account) to be able to post messages, change how messages are displayed, and view media in posts.
- Boards
- Nintendo 3DS
- After seeing the pricetag of SMTIV for the 3DS...
CrisisOfFate 4 years ago#11
bsp77 posted...First printings of the game have a CD, art book and guide. That is why it is $50. Nothing to do with everything you wrote.
If all games from now on have all those extras I'll gladly pay extra 10 euros/dollars or whatever.
The official Azrael of the Shin Megami Tensei IV board.
Proud supporter of NO Persona in SMTxFE
pikachupwnage 4 years ago#12
Tiael posted...
Well, it's only $50 due to the extras, especially the 176 page art/strategy book, which is also the first print run.
Wait the book is 176 pages?
Holy **** tacos!
Walharts. Low prices. Everyday. On Everything.
Official maribelle of the Fire emblem awakening board! Official pokemon fanboy of the NDF!
Come to PAL territories. 50 is the set price tag.
Even new DS releases used to cost 50 euros here. I imagine Australia has it worse than Europe.
TakayaNoriko: Back in my day, we pressed buttons that didn't do anything because we thought it would give us special power-ups. And that's the way we liked it!
pikachupwnage posted...
Tiael posted...Well, it's only $50 due to the extras, especially the 176 page art/strategy book, which is also the first print run.
But this was said the same day it got announced :C how didn't you know? either way it's a guide and artbook and I think that alone is worth the $10 cause the cheapest Atlus artbook is like $30 .
The official Loki of the Shin Megami Tensei IV board
Darn beautiful men, always eating out of my trash wait what?
PhaseSlaethe 4 years ago#15
CSplitter posted...
Come to PAL territories. 50 is the set price tag.
Dropping 50 for a game isn't bad for an Aussie when their minimum wage is like 3x what America's is.
esoteric42 4 years ago#16
I'd pay an extra $10 if every game I bought came with a CD and artbook/strategy guide that was over 150 pages.
I'd also buy digital if I got a $5-$10 discount from retail.
US 3DS Friend Code: 4511-0481-8141 (Bryan)
From: PhaseSlaethe | #015
Dropping 50 for a game isn't bad for an Aussie when their minimum wage is like 3x what America's is.
But if the price of everything is increased to compensate for the much higher minimum wage, then in the end, despite being a larger amount, you still only go as far with it as an American would since the price of everything is also higher than what America's is.
1) Help existing developers, who already make great games, providing a incentive to make even better games. If they don't (to reap the profits), that's fine too because the extra $10 from all sales will help lessen the gap for the sequel. What used to require 1 million sales will now require .9 million sales to warrant a sequel.
A lot of this has more to due with runaway budgets, long development cycles, and devs wanting to make AAA games. A lot of studios have gone out of business then gen because they've made expensive gambles that didn't pay off.
Fix that and have companies who are willing to have some scaled-down, realistically budgeted projects and they'd have less problems when their games don't sell five million copies worldwide.
2) Probably bring companies like EA back from the world of microtransactions to the world of making decent games as they would not need to rely on the microtransactions nearly as much since they earn $10 more for every sale.
If you think for one moment that game companies would stop microtransaction and DLC practices that are working for them even if they raised game prices, then I gotta ask how you've maintained such a positive outlook on the world for so long. I could only see a world where they do both in tandem.
3) More companies and groups would start to enter the market when they see enough of a economic profit, thus increasing the overall quality of games due to intense competition.
Honestly, I think if any company wants in on the game market, they'd either start doing licensed game work or they'd focus on bite-sized mobile/facebook/psn/eshop/live games before they'd get their feet wet on retail game development. They're not going to go HAM and jump on in, unless they've got the capital and experienced team members.
I don't mind $50 portable games (I preordered SMTIV before the bonuses were announced), but that's really only for tried-and-true companies and series that I really like. Otherwise I wait for the game's prices to fall in a few months, or I get it used. Perhaps more people would do that same if games got more expensive on average, which would kind of even out profits made by such a move. Maybe your optimistic predictions would be right. Who knows.
He's gonna kick that burger!
I'm sure you can get it for $40 on the eshop. I just want to play the game, so that's the version I'll get.
^ go here if u wanna play Phantasy Star Online for Gamecube, Dreamcast,and PC (for free)
RX02Banshee 4 years ago#20
PhaseSlaethe posted...
CSplitter posted...Come to PAL territories. 50 is the set price tag.
Because living here is obviously going to cost the same as it does in the US and we're all filthy rich. /sarcasm
Official Piplup of the Pokemon X board.
Bethesda make poorly made shallow quantity over quality games.
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- Nintendo 3DS
- After seeing the pricetag of SMTIV for the 3DS...
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Star PGT14T Description
The Star PGT14T Pro-Max® panini grill with timer can be used to prepare grilled sandwiches, meats, and vegetables with an electronic programmable timer for recording cooking times. The 14 inch square platens on this Star Manufacturing grill are made from durable aluminum to last longer with better performance. The splash guard on the bottom platen reduces mess, and the removable grease drawer simplifies clean-up. This panini grill with timer replaces the CG14T.
Product Details
- Pro-Max® Series
- Replaces model CG14T
- 14-in. x 14-in. grooved aluminum cooking platens
- Electronic countdown timer
- Hinged top platen
- Thermostat can be set to temperatures between 175 to 550 degrees F
- Grooved design adds visual appeal to grilled foods
- Removable grease drawer
- Water-resistant electrical connections
- Adjustable feet with non-slip material
- Constructed from stainless steel
- 120 V/60 Hz/1-ph, NEMA 5-15 plug with 6-ft. cord included
- Overall dimensions: 19-5/8 in. W x 24-5/8 in. D x 14-1/4 in. H closed (33-in. H open)
- CE and ISO 9001:2000 Certified, cULus and UL-EPH Listed
Easier and Faster Cooking
- Both platens heat up food for faster cooking
- Thermostat can accurately detect food temperatures, giving better control over cooking environment
- Top platen adds 3- to 4-lbs. of pressure on grilled items, distributing heat better through the food
- Aluminum grill surface adds durability and conducts heat efficiently
Flexible to Your Cooking Needs
- The Star Pro-Lift™ hinge system lifts 3-in. before rotating to accommodate tall sandwiches and larger food items
- Countdown timer can be set up to 9:59-min. and sounds an audible alarm when timer is finished
- On/Off switch selects between both platens on, bottom platen on, and both platens off
- Stainless steel and hinged design for easy cleaning
- Note: this product replaces CG14T
Pro-Max® 2.0 "Panini" Grill, electric, single, 16.5" W x 23" D (OA), standard hinged upper grill, grooved aluminum plates, lower profile & aesthetics, analog temperature control, electronic timer, thermostat from 175° F to 550° F, bottom splash guard, removable grease drawer, stainless steel front & sides, non-skid feet, cULus, UL, CE (old model reference: CG14T and CG14TB), 120v/60/1ph
*The warranty will not be honored for residential or non-commercial use of any Commercial Equipment.
Star PGT14T SpecificationsPDF Spec Sheet
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text: Thanks for sharing photos of Palm Sunday and Easter! The Paschal candle is spectacular- so easy to do using the jello mold ring, yet so effective and festive. The idea of a fan of palms around the Gospel on Palm Sunday is one I have never seen before- very nice. Got photos? Please send to email@example.com. Thanks Susan- and the hard-working guild at Epiphany for a beautiful Easter and Holy Week effort.


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Hutchison sharp as Blue Jays beat Orioles 5-1
TORONTO (AP) Drew Hutchison gave the slumping Blue Jays a timely gem.
Hutchison came within one out of his second career complete game, Jose Bautista homered and drove in three runs and Toronto beat the Baltimore Orioles 5-1 on Wednesday night, snapping a four-game losing streak.
"Perfect timing, we were struggling a little bit," manager John Gibbons said. "We needed that."
Melky Cabrera had three hits as the Blue Jays closed within four games of the AL East-leading Orioles and handed Baltimore its first loss in four games.
Hutchison (8-9) struck out eight and allowed just one hit, a solo homer by Chris Davis in the second, to win for the second time in three starts. Hutchison responded to the homer by setting down 22 straight batters but was replaced after Nick Markakis walked in the ninth.
"After he gave up the home run he really buckled down," Davis said. "We just couldn't square anything up."
Casey Janssen came on and finished it by getting Manny Machado to foul out.
Hutchison is 3-0 with a 1.13 ERA in six career starts against Baltimore.
"Me and (catcher Dioner) Navarro were on the same page pretty much every pitch tonight," Hutchison said.
Davis, who also homered in Baltimore's 9-3 win on Tuesday, went deep in back-to-back games for the first time since Aug. 12 and 13, 2013.
All five Toronto runs came with two outs, and the Blue Jays collected nine two-out hits.
Wei-Yin Chen (12-4) had won his past five starts but couldn't extend that career-best streak, allowing four runs and eight hits in five innings. He walked two and struck out six.
"We didn't give him much margin for error," Orioles manager Buck Showalter said.
Blue Jays: Third baseman Brett Lawrie, who left Tuesday's game with a sore back, was held out of the lineup. Gibbons said Lawrie's MRI results have been sent to team doctors in Florida for review. First baseman Adam Lind (right foot) will begin a rehab assignment with Toronto's Gulf Coast League team on Thursday and could rejoin the Blue Jays this weekend, Gibbons said.
Orioles: Right-hander Ubaldo Jimenez (right ankle) felt fine after throwing a 35-pitch bullpen session before the game, but Showalter wouldn't divulge when Jimenez might return to the mound. Showalter did confirm, however, that right-hander Chris Tillman will start Friday's home game against St. Louis.
Baltimore right-hander Miguel Gonzalez will try to bounce back after losing for the first time in four starts, allowing four runs in five innings against Seattle last Saturday. Blue Jays left-hander J.A. Happ will make his second start against the Orioles this season. He won in Baltimore on June 15, allowing one run over six innings.
Davis has 24 career home runs against the Blue Jays, his highest total against any opponent. The Orioles slugger entered Wednesday's game with a career .668 slugging percentage against Toronto, the highest of any Blue Jays opponent (minimum 200 plate appearances). Baltimore teammate Nelson Cruz is second at .610. Davis, who batted seventh on Tuesday, moved back to the fifth slot Wednesday.
Cruz went 0 for 3 with a strikeout and has just two hits in his past 38 at-bats. Cruz came in with a .438 average in four previous games at Toronto this season, where three of his seven hits have been home runs.
Toronto won for the sixth time in eight games at home and improved to 31-24 at Rogers Centre this season. The Blue Jays lead the AL in home runs (75) and extra-base hits (186) at home this season.
Toronto promoted pitching prospect Daniel Norris to Triple-A Buffalo. Norris is 9-1 with a 2.38 ERA in 21 games at Class-A and Double-A this season.


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Legal Question in Family Law in Georgia
I live in Savannah Georgia and i am 17 years old. I am pregnant. Can i move in with my sister who is 21 instead of my parents?
Asked on 10/01/13, 3:20 pm
1 Answer from Attorneys
Glen Ashman Ashman Law Office
Unless your parents agree, no.
Answered on 10/01/13, 3:40 pm


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The case of a 16-year-old young woman successfully suing her parents to assure that they will support her choice to … Continued
Why the health care fight is also about abortion
MLADEN ANTONOV AFP/GETTY IMAGES Anti-abortion protesters pray outside the Supreme Court on the third day of oral arguments over the … Continued
Living without religion
Earlier this year, the Center for Inquiry, an Amherst, N.Y.-based atheist group, initiated a controversial and provocative ad campaign in … Continued
From Jesus' socialism to capitalistic Christianity
A truly strange thing has happened to American Christianity. A set of profound contradictions have developed within modern conservative Christianity, … Continued
SOTU: U.S. is a Miracle
President Barack Obama is applauded by Vice President Joe Biden and House Speaker John Boehner on Capitol Hill in Washington, … Continued
On Churches and Dictators: The Pope Comes to Britain
By Eric Heinze If Pope Benedict XVI doesn't go down as one of history's most beloved pontiffs, he'll certainly go … Continued
Religious freedom officials enter Ground Zero debate
By Michelle Boorstein What position — if any — should members of America's primary government body dedicated to religious freedom … Continued
Meaning in a homeless man's death
By Jeremy BurtonSenior Vice President of Philanthropic Initiatives Jewish Funds for Justice This week, Jews around the world will celebrate … Continued
Red Tories and tea parties
Unorthodoxy By Patrick J. Deneen On the evening of Thursday, March 18, and much of the following Friday afternoon, there … Continued
Establishment Clause doesn't limit foreign policy
JUST LAW AND RELIGION Michael Kessler Does the Establishment Clause prevent the President from using or aiding religion as part … Continued
6 Questions for S. Court Nominee
JUST LAW AND RELIGION By Michael Kessler President Obama will soon announce his nominee for the next Supreme Court justice. … Continued
No Apology, Sanction To Theocrats
How would you respond to radical Muslim clerics in northwest Pakistan — now under Islamic law — who are calling … Continued
Obama vs. Osama in Muslim World
As he travels to Turkey April 7, President Obama takes the next step to fulfill his pledge to address the … Continued
Conversation and Conversion
Islam has succeeded in much of the world partly because it is intellectually interesting, culturally potent, and has spiritual power. … Continued
Bible Classes in Texas Public Schools
As a source of divine inspiration, prophetic imagination and poetic wisdom, the Bible is unsurpassed. As a classroom textbook, well, … Continued
A Theocratic Nation Is Deeply Dangerous
No. American is not a Christian nation. It has never been one. Nor should it ever become one. In the … Continued


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The Del Mar Art Center gallery will hold an opening reception for its Summer Exposition from 5 to 8 p.m. July 20 at 1555 Camino Del Mar, Suite 112. The Summer Expo focuses on the local beach scene through paintings, glass works, ceramics and sculpture. Prizes will be awarded for best beach attire. The show runs through July 29. Visit dmacgallery.com/events.html .
DEL MAR: Art gallery to hold reception
Copyright © 2017, The San Diego Union-Tribune


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Movies & TV / Columns
411mania Inteviews: Disney Junior star Kiara Muhammad
Kiara Muhammad is one of the biggest TV stars you've never heard of, although if you have kids under 10 years old you have more than likely heard her voice; Doc McStuffins is the single most watched show on all of television among 2 – 5 year olds and has been since its premiere on Disney Junior earlier this year. 13 year old Muhammed had acting appearances on Hannah Montana and Curb Your Enthusiasm already on her resume before she began voicing the title character on the animated smash.
Al Norton: It's a pleasure to talk with you; you're the star of my kid's favorite TV show.
Kiara Muhammad: Thank you (laughing). That's great.
Al Norton: It seems to me that you have the best of everything because you have a show that is a huge hit but you can go out in public without people bothering you.
Kiara Muhammad: Oh, yeah. I never thought of it like that but yes, that is true.
Al Norton: How did you get the job?
Kiara Muhammad: My agent submitted me for the role and it was one of my first voice over auditions; I was just getting started at the time. I did the audition and then got a call back and was so thankful and surprised. I went in a second time and a couple of weeks later they called me and said I got it. I was really shocked and was also really happy and proud of myself because it was my first time doing it.
Al Norton: How is voice acting different than the other acting you've done?
Kiara Muhammad: Voice acting you have to put all the emotions through your voice but with on camera acting they can see your expressions and body language so they can see what you're trying to bring to them. Voice acting is kind of a little harder because it's all in your voice.
Al Norton: Did you get to see what Doc McStuffins was going to look like before you started playing her?
Kiara Muhammad: On the script they had a picture of her so I could see what she was looked like.
Al Norton:You've got some great co-stars, like Loretta Devine, who is so awesome; how much interaction do you have with them?
Kiara Muhammad: I've only seen Loretta once (laughing). We met at the Doc McStuffins premiere party. I've seen the other cast members a little more just because Loretta is so busy. The other actors and I see each other coming in out of the studio some time.
We've been trying to do an episode with the whole cast together but we all have such busy schedules that we can't work it out but hopefully we will in the future.
Al Norton: Did you have any idea how popular the show would be, and how quickly?
Kiara Muhammad: I did not. We're not even done with the first season and it's just amazing. I go on Twitter and search the hashtag Doc McStuffins and I haven't seen one bad comment about it. Literally everything is good. I see things like, "watching Doc McStuffins with my three year old, it's his favorite episode." It's amazing and I am really happy about it.
Al Norton: How do you balance your work with being a regular teenager?
Kiara Muhammad: I try to find time to hang out with my friends as much as possible. I do Doc Mondays and Tuesdays. It's harder if I am also doing an on-camera show but we figure it out. It's hard if I have to miss school because then I am doing my current work plus whatever I missed. I try to work it out because I like having good grades and I like acting.
Al Norton: Does everybody at school know about your job?
Kiara Muhmammad: Not everybody, really just my friends. I'm in high school so not a lot of people are watching Disney Junior (laughing).
Al Norton: Hey, you're almost a real life Hannah Montana that way.
Kiara Muhammad: I guess so (laughing).
Al Norton: I have to ask, did I see that you have the nickname "Fufu?"
Kiara Muhammad: Yes (laughing). I was kind of a little weird when I was growing up and my Dad just randomly picked that out for me, I'm not sure why. All my aunts and uncles and cousins call me Fufu.
Al Norton: And you're ok with that?
Kiara Muhammad: Yes, I'm used to it. I'll turn my head when I hear "Fufu."
Al Norton: That can't be too often when it's not you someone's calling.
Kiara Muhammad: One time I was a restaurant with my family and they called out an order for "Fufu" and my Aunt told me to go get my food but I hadn't put it in under that name. A girl my age came out and got her food and we were all laughing going, "there is another Fufu!"
Don't miss a brand new episode of Doc McStuffins premiering today at 10am (ET) and running all weekend long on Disney Junior.


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