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Resident Evil 3: Nemesis
Review by horror_spooky
Reviewed: 07/02/08
Resident Evil 3: Nemesis is one of the most popular games in the series because it introduced some new gameplay mechanics that revitalized the terror that wasnt found in the second game and it also helped fix some of the previous games problems with control while adding some new movements to make the overall experience much smoother. Nemesis had the potential to surpass the original in terms of quality, but due to its short length the overall value of the game is brought down some. Still, Nemesis is loads better than Resident Evil 2 and is nearly just as good as the first game was, so it definitely deserves the attention of any fan and any gamer who is into the survival horror genre.
The main feature of this game and the part of the game that makes it absolutely terrifying is the new gameplay mechanic where the games main antagonist follows you around and constantly tries to kill you. The developers realized that the scariness of the Resident Evil games just wasnt there anymore, so they, in a brilliant design decision, created Nemesis, the creature created by Umbrella to hunt down and kill all members of the S.T.A.R.S. team. This includes you, Jill Valentine, and you will be absolutely terrified whenever you hear Nemesis moan, Staaaaars or when you see this hulking mass of a monster slowly walking towards you, knowing any second that he could all of a sudden speed at you and rip you to shreds.
Nemesis is one tough dude and one very smart creature, especially compared to the usual Resident Evil fodder of zombies. This guy knows how to operate weapons and he does so throughout the game to try and kill you. However, hes also pretty speedy when he needs to be and can easily take you out, resulting in a very untimely death for the protagonist. You can try to kill Nemesis all you want, but he just falls to the ground, delayed, and will eventually get back to his feet and continue his pursuit. The best option is to run away, but this guy can follow you through rooms if he wants and while there are pre-determined times in the game where he will appear, he also will randomly appear and stalk you every once in a while, so the tension and fear is always there as you walk around Raccoon City, desperately looking for a way out.
I mentioned improvements to the controls and some added abilities, and there definitely are those. The tank controls are improved with a 180 degree turn available to help you run away from enemies much quicker than you could in the previous two games, which will definitely save you some health, ammo, and time. Jill has also bettered herself so she can now dodge enemy attacks and even knock enemies back when they try to attack her. These little improvements make the game feel more sophisticated than its predecessors.
Resident Evil 2 had a larger focus on action, which I felt hampered the experience and creepy atmosphere somewhat, but Resident Evil 3 has an even higher focus on action, but it does it right. By adding Nemesis to the equation, Resident Evil 3 has successfully helped the Resident Evil series transition to be more action oriented while maintaining that all important scare factor. There are definitely better guns for your protection and a ton of more ammo for you to plug into enemies, but there is also a neat little ammo creation system where you use gunpowder to create ammunition of various kinds. While this system did seem a little unnecessary, at least the developers were trying out something new that didnt make the overall experience any worse.
A randomization feature is included in the game that will switch items, enemies, and cut-scenes around, but one feature that is a definitely switch from the previous Resident Evil game is that at certain points in the game you are presented with choices. You get three options, with the third option being ignore the two choices given to you. The choice you pick will determine how the story goes and ultimately what ending youll receive, and this is a very nice addition to the Resident Evil formula.
Resident Evil 3 has the usual unlockable content in Resident Evil games like various costumes and endings, but the game also has its own mini-game called Mercenaries. This mini-game is similar to Resident Evil 2s Extreme Battle mode in that you are timed and have to get to a certain location before the time runs out. You can choose from three characters that are all a part of Umbrellas military and have varying items and weapons. You can extend your time, earn new items, and regain ammo by killing zombies to save civilians, similarly to the House of the Dead games. You are given points after you complete a Mercenaries game and you can use those points to buy new weapons to use in the main game to make your game go by even quicker.
Various environmental hazards are now at your disposal to use against the undead. You are able to shoot pipes to cause some acid to spray on them and you can also shoot explosive barrels to blow the bastards to hell. Its a little bit different than what youre used to, but its still a cool gameplay mechanic.
Beating a Resident Evil game as fast as you possibly can has always been a big part of the series and Resident Evil 3 is no different. Unfortunately, the puzzles are ridiculously easy this time around and you can beat the main game in under three hours on your first play through with relative ease. By getting a good ranking you unlock various things, but by repeatedly beating the game you earn extra epilogue endings for various characters in the series including Claire, Barry, Leon, Ada, and Sherry, plus some other favorites. These epilogues are definitely worth beating the game over and over again just to see.
The plot in Resident Evil 3 can be a little confusing as part of it takes place before Resident Evil 2 ever happened and the rest of it takes place after the events in Resident Evil 2, but you shouldnt have too much of a problem. To catch you up to speed, people didnt believe the survivors from the original game after they told them of Umbrellas evil intentions, and because of that disbelief, Raccoon City was left vulnerable and someone let out the T-Virus. This virus mutates people into zombies and creates various other hideous beings. The city has been taken over, but most of the S.T.A.R.S members had already left town, except for Jill Valentine and Brad Vickers, the wussy pilot that ditched his team in the original game, forcing them through the hell that was the mansion in the first place. They need to get out of the city and fast, but with the U.B.C.S. roaming the town killing everything they see and a new threat created by Umbrella to specifically kill them named Nemesis, the two S.T.A.R.S. members may have bitten off more than they can chew this time. There are plenty of shocking moments, but once again its hard to tell whats canon and whats not due to the multiple endings and the different ways the story can go.
For the PlayStations power, Resident Evil 3 does some pretty amazing things. The ability to interact with the environment has never been as great as it is in any survival horror game released for the system until Resident Evil 3 and the character models are great. The enemies look much better than they did in the original game, but it is a shame that some of the environments were recycled from Resident Evil 2. Nemesis is a menacing and terrifying creature, which is exactly what the developers were going for when they designed him. The environments look nice and the cut-scenes are of Final Fantasy-caliber, so theres definitely nothing to complain about there. However, there are some glitches that can be pretty annoying and the game still loads way too often like its predecessors which can be a pain in the ass when you get stuck and have to backtrack a lot.
Nemesis sure has some creepy moans and he will definitely make you shiver in absolute, pure fear. When you are just walking along a corridor, minding your own business, and looking for an item you need to solve a puzzle, you will probably wet your pants when all of a sudden the music jumps and this huge guy with a bazooka jumps through the window. The soundtrack when Nemesis is around is blood pumping and gets you even more terrified and how the music changes right before key moments is a feature that Im glad is finally working as well in video games as they have in films. The soundtrack is great and while the voice acting still isnt perfect, its leaps and bounds over the original.
Resident Evil 3 has got to be the shortest game in the series as you can easily complete it in under three hours on your first time through. There is a ton of stuff to unlock, though, and to unlock everything you have to play through the game a minimum of eight times. Theres an extra game mode that you can play through with the incentive of purchasing better items to make your ride through the main game much easier, and overall Resident Evil 3 does have some replayability and will still last you quite a few hours, but it just doesnt have the staying power of its predecessors.
I remember being absolutely afraid of Resident Evil 3 when I first saw someone play it as a child, but it is a good thing when a video game can scare the hell out of you so badly, even a game as old as this one. Nemesis had the potential of being the best Resident Evil game released in the fifth generation, and hell, even the best survival horror game released in the fifth generation overall, but its short length really killed it. Thankfully, there is still tons of stuff to due and the game will keep any fan of the series busy for a while, plus there are some references to Capcoms other games that fans of the company can definitely appreciate. Resident Evil 3: Nemesis is a must-have for survival horror or Resident Evil fanatics and is simply one of the best games released for the PlayStation.
Rating: 4.0 - Great
Product Release: Resident Evil 3: Nemesis (US, 11/11/99)
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MARTINEZ — A Concord man who fired shots into a bar in a 2010 incident that left a victim temporarily paralyzed has been sentenced to 40 years to life in prison.
Nicholas Cox, 31, was a parolee when, on March 7, 2010, he left Vinnie's Bar & Grill just off Concord's Todos Santos Plaza after a confrontation, prosecutor Simon O'Connell said. Witnesses heard him tell a female acquaintance, "I want to borrow your car to shoot someone."
Minutes later, O'Connell said, witnesses saw Cox drive slowly past the bar and open fire, with multiple shots hitting the front of the bar and parked cars. A 30-year-old man who was smoking outside the bar was struck in the back and neck, causing injuries that left him paralyzed for 45 days, O'Connell said. No motive was ever established for the shooting.
The victim was able to walk into a courtroom to testify against Cox during his trial. A jury convicted Cox in October 2013 on two charges related to the shooting but hung on attempted murder and shooting into an occupied building charges, as well as charges stemming from a shooting outside the Premier Inn on Concord Avenue later that night.
Contact Gary Peterson at 925-952-5053. Follow him at Twitter.com/garyscribe.

subset: commoncrawl


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Unseen film footage of comedian Jerry Lewis, which he vowed would never be seen by the public, has surfaced on Youtube.
The 1972 movie "The Day the Clown Cried" about a circus clown during the Holocaust was withdrawn by the actor after several disastrous test screenings. Lewis, who starred in and directed the movie, concluded that the film was beyond repair and promised to hide it forever.
"It was bad, and it was bad because I lost the magic," said Lewis in an interview at this year's Cannes Film Festival. "You will never see it. No one will ever see it, because I'm embarrassed at the poor work."
The film tells the story of a German circus clown who after being arrested by the Nazis, was ordered to lead children into the gas chambers of Auschwitz as punishment.
Actor Harry Shearer, who saw a rough cut of the film, said in a 1992 Spy magazine article: "With most of these kinds of things, you find that the anticipation, or the concept, is better than the thing itself. But seeing this film was really awe-inspiring, in that you are rarely in the presence of a perfect object. This was a perfect object. This movie is so drastically wrong, its pathos and its comedy are so wildly misplaced, that you could not, in your fantasy of what it might be like, improve on what it really is. "Oh My God!" – that's all you can say."
Lewis had initially thought himself wrong for the role, according to his autobiography Jerry Lewis in Person. He told producer Nathan Wachsberger, "Why don't you try to get Sir Laurence Olivier? I mean, he doesn't find it too difficult to choke to death playing Hamlet. My bag is comedy, Mr. Wachsberger, and you're asking me if I'm prepared to deliver helpless kids into a gas chamber? Ho-ho. Some laugh – how do I pull it off?"
How indeed.


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I LOVE HARRY POTTER. That's about all you need to know...and message me on MySpace and tell me that you know about my stories!
Author's Response: Sorry
I have to tell you that I don't usually read Hermione/Draco, but it was good...If I am correct in saying this, I believe that was actually the first one I've ever read and I have been reading for quite a while. Good job!
Author's Response: Thanks very much for the kind words! I know a lot of people don\'t like the pairing, but I feel like they work well together if well written.
OMG I love this story so much...thought you'd like to know...anyway, I'm very much looking foward to an epilogue...anyway, keep writing-you are so talented!
It was good....I think it's such an interesting plot...one thing- the Dumbledore thing was a bit awkaward ( I have no idea if I spelled that right...lol...) but other than that it was REALLy good...
I love this story...Again, you have put so much emotion into words that it overwhelms the reader, pulls the reader into the story to feel the characters pain, passion, happiness or whatever else the character is feeling at the time. A job well done!
Author's Response: Thank you so much. The emotions are, obviously, very important to me. When a writer is successful, they have some aspect of their writing that pulls the reader in. Be it suspense, or character development, or plot, you know, there is a hook, and with me I think it is the emotion, and being able to tap those emotions, it is what has allowed me to tackle the complex Epilogues plot because it is what is that link. Sure, I may finish every chapter with a cliffhanger, but I think what makes that cliffhanger is the fact that you know that when you finally see what happens, you know there is going to be an explosion of emotion on the other side. In essence, I have created this plot, and it is the emotions regarding this plot that holds it together. So thank you very much and I hope you\'ll join me for the next chapter!
Omigod...that was such a freaky chapter...It was amazing- as always- but really creepy...Great job!
Author's Response: heh... Thank you so much, and I\'m glad you thought the appetizer is freaky... wait until you see the main course.
I had absolutely no idea what a bald man did with a comb...I just have to say that this chapter was quite upsetting. Don't get me wrong, it was really good, just upsettign...Tonks!!!! :(
Author's Response: You know, it\'s interesting, this chapter has gotten a lot of reviews from people such as yourself who don\'t review often or even at all, and i appreciate that. just something i thought worth mentioning. And yeah, it was meant to be an upsetting chapter, I knew that people wouldn\'t be happy about Tonks\' death, but I did that on purpose. I think you kinda have to be mean to your audience sometimes, you know? Thank you so much.
LOVE the story- it is SO CUTE!!!
Author's Response: Glad you love this fanfic, and that you thought it to be cute! Thanks for the review! :D


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MAR 105 (Oceanography)
(1) Course Syllabus
Student Outlines:
(2) Section 1
(3) Section 2
(4) Section 3
Powerpoint presentations:
Section 1
(1) Intro. 1
(2) Intro 2 (no need to print – LI info.)
(3) Plate Tectonics, lecture 3
Section 2
(6) Atmospheric Circ., Lecture 6 (note: print out w/ #7, below, as I may start w/ that lecture first)
(7) Ocean Circ., Lecture 7 (see note above)
(8) Waves, lecture 8
(9) Tides, lecture 9 (note: material may be covered in section 3 of course?)
Section 3
Notes: See notes at end of section 2, above. Material may be covered in a different order than presented here – refer to course syll. For order of lecture material to be covered (& print out in appropriate order)
(10) Coasts and Beaches, lecture 10 (print 3rd for section)
(11) Capstone, lecture 11 (last lecture of semester, do not print)
(12) Marine Biology Lecture (Print 2nd, attach w/ plankton, below; stop printing @ invertebrates slide series)
(13) Plankton (print 1st for section)
(14) If time permits: "Pollution Lecture" (for use w/ Capstone, do not print)
(15) If time permits: "Global Climate Change" lecture (for use w/ Capstone, do not print)
Please note that all labs are now copied and bundled together and SHOULD BE PURCHASED AT THE BOOKSTORE. However, if you need to view an (old) copy they can be accessed here:
(2) Plate tectonics Lab (prelim. Only), remaining materials available from Instructor
(3) Ocean Contour 1 (w/o graph)
(4) Ocean Contour 2 (w/o graph)
(5) To get graphs (for Ocean Contours, above) you can either (1) Make your own or (2) view Dr. McNamara's site at:
http://www2.sunysuffolk.edu/mcnamam/MAR105Lab.htm for link.
(6) Powerpoints/Slides for "Plate Tectonics" & "Ocean Contour" Lab(s)
(9) Salinity, Temp. and Density
(10) Waves
(11) Capstone
(12) Marine Bio (info. Only – not a semester lab)
(13) Pollution
(14) Plankton
(3) Perfect Storm (EC)
(4) Perfect Storm (EC)
(6) Capstone – extra credit!
(7) Article Project
Field Trips:
(2) Cedar Beach Field Trip Directions
(3) American Museum of Natural History - AMNH Extra Credit Option
(4) AMNH directions
(5) Long Island Aquarium (old Atlantis Marine World) – see Marine Biology page for link to question
(7) Cradle of Aviation (IMAX) EC – visit the museum and watch "Sea Monsters" (or other Oceanography/Marine Bio based film) & write a reaction paper


text: Search Results Studies Variables Publications (1) Your query returned 1 citations. Sort by: Pub Date (newest) Title Recent Additions Author Clear All Pub. Year Citation 1. 1986 Hoffer, Thomas Bruce . Educational Outcomes in Public and Private High Schools. Dissertation, University of Chicago. Export Options: RIS EndNote XML Results 1 - 1


text: On Tue, Jan 19, 2010 at 9:25 AM, Xyne <xyne at archlinux.ca> wrote: [..] > Afaik, it is Arch's official policy to support the latest _stable_ > releases of upstream packages, which means that 2 is the only > acceptable choice. I would also recommend downgrading if you expect the > problems caused by the early push to last for several weeks. You can > always push the new version to [testing] instead but such breakage > should not occur in the main official repos (core, extra, community). > > Would this plan preclude compatibility between binary and AUR packages? > One way of reading the proposal is that the binary packages in the > official repos would form one set and the packages in the AUR would > form a separate and mutually exclusive set that the user would be > required to keep apart. I am sorry if this question is ignorant but I > still do not fully understand the complexities of building haskell > packages. If this interpretation is correct then I would argue that the > AUR is intended to complement the official repos, not to act as an > alternative to them, but I hope that this interpretation is wrong. The biggest problem I see is that while GHC supports having multiple version of the same module available at the same time, pacman doesn't. That would mean that keeping a binary and an AUR version of the same package requires that they have different names. Not a big problem really, but it should be policed a bit. The bigger problem that users *will* run into is diamond dependency issues (A uses B and C, both B and C use D but different versions). I believe that avoiding that would require a *very* strict policy on what goes into both binary repos and AUR. Too strict to follow the "Arch way", I think. > Considering the complexity of this issue, perhaps it would be a good > idea to create independent haskell repos to host compatible binary > packages and/or an official AUR-clone for all of the current haskell > packages in the AUR. You could then support the latest stable versions > in the offical repos and maintain compatible packages for them in the > AUR, and let users who require the latest versions use the official > haskell repository and AUR-clone (or just cabal2arch) to acquire the > very latest versions. This is an interesting idea, especially if we get some tool support for that. AFAIK all "AUR builders" (yaourt, paktahn, etc) only know about AUR, so they need to be made a bit more configurable. /M -- Magnus Therning (OpenPGP: 0xAB4DFBA4) email@example.com Jabber: email@example.com http://therning.org/magnus identi.ca|twitter: magthe


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Delaware State Police say they've arrested a Rehoboth Beach man who stole his grandmother's credit card and used it to purchase more than $2,500 worth of items.
Troopers say they arrested Maxwell Schenck on Friday at a home on Grandview Street in Lewes and charged him with theft and 61 counts of unlawful use of a credit card. Troopers say Schenck was living with his 82-year-old grandmother when he took her credit card. He used it to make purchases at Wal-Mart, Safeway, Royal Farms and Ruby Tuesday.
Troopers arrested Schenck after an anonymous tip.
He is being held on $126,000 bail.
Published at 12:16 PM EST on Jan 12, 2013


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Toll-like receptors (TLRs) are critical for the recognition of inhaled pathogens that deposit on the airway epithelial surface. The epithelial response to pathogens includes signaling cascades that activate the EGF receptor (EGFR). We hypothesized that TLRs communicate with EGFR via epithelial signaling to produce certain innate immune responses. Airway epithelium expresses the highest levels of TLR2, TLR3, TLR5, and TLR6, and here we found that ligands for these TLRs increased IL-8 and VEGF production in normal human bronchial epithelial cells. These effects were prevented by treatment with a selective inhibitor of EGFR phosphorylation (AG-1478), a metalloprotease (MP) inhibitor, a reactive oxygen species (ROS) scavenger, and an NADPH oxidase inhibitor. In an airway epithelial cell line (NCI-H292), TNF-α-converting enzyme (TACE) small interfering RNA (siRNA) was used to confirm that TACE is the MP involved in TLR ligand-induced IL-8 and VEGF production. We show that transforming growth factor (TGF)-α is the EGFR ligand in this signaling cascade by using TGF-α neutralizing antibody and by showing that epithelial production of TGF-α occurs in response to TLR ligands. Dual oxidase 1 (Duox1) siRNA was used to confirm that Duox1 is the NADPH oxidase involved in TLR ligand-induced IL-8 and VEGF production. We conclude that multiple TLR ligands induce airway epithelial cell production of IL-8 and VEGF via a Duox1→ ROS→ TACE→ TGF-α→ EGFR phosphorylation pathway. These results show for the first time that multiple TLRs in airway epithelial cells produce innate immune responses by activating EGFR via an epithelial cell signaling cascade.
- TNF-α-converting enzyme
- dual oxidase
- transforming growth factor-α
- cell signaling
toll-like receptors (TLRs) that identify pathogen-associated molecular patterns are critical for recognition of a variety of inhaled pathogens that deposit on the airway epithelial surface. Certain epithelial responses to these pathogens involve signaling cascades that activate the EGF receptor (EGFR; Refs. 25, 26) to recruit leukocytes (18), to produce mucins and thus remove pathogens (31), to produce antimicrobial peptides to kill pathogens (30, 32), to increase wound repair (15), and to stimulate angiogenesis (6) and thus reconstitute damaged tissues.
Airway epithelial cells express high levels of TLR2, TLR3, TLR5, and TLR6 [which heterodimerizes with TLR2 (TLR6/2)]. These TLRs recognize pathogen-associated molecular patterns of bacteria, viruses, and fungi (24). We hypothesize that these TLRs, including TLR1 [which heterodimerizes with TLR2 (TLR1/2)], all communicate with EGFR to produce innate immune defenses. In this study, we examined two innate immune responses: 1) epithelial production of IL-8, a potent chemoattractant for neutrophil recruitment (to phagocytose pathogens); and 2) epithelial production of VEGF, which recruits blood vessels to inflamed and damaged airway epithelium.
Here, we show that activation of TLR1/2, TLR3, TLR5, and TLR6/2 (hence all referred to as TLRs) produces IL-8 and VEGF via EGFR activation in normal human bronchial epithelial (NHBE) cells. In NHBE cells, the TLR ligand-induced IL-8 and VEGF production involves a cascade that includes an NADPH oxidase (Nox), reactive oxygen species (ROS), a metalloprotease (MP), and EGFR. To determine whether TNF-α-converting enzyme (TACE) is the MP in this signaling cascade, we used TACE small interfering RNA (siRNA) in an airway epithelial (NCI-H292) cell line. In these experiments, we identified transforming growth factor (TGF)-α as an important EGFR ligand involved in the responses, using neutralizing antibodies (Abs) and measuring TGF-α in airway epithelial culture supernatants. To determine whether dual oxidase 1 (Duox1) is the Nox in the TLR ligand-induced signaling cascade, we used Duox1 siRNA in NCI-H292 cells. These results suggest a stereotypical signaling cascade in both NHBE cells and in a human airway epithelial (NCI-H292) cell line, with different TLRs signaling via a pathway that includes Duox1, ROS, TACE, TGF-α, and EGFR activation, and initiating innate immune responses in airway epithelial cells.
AG-1478, AG-1295, AY882, TNF-α proteinase inhibitor-1 (TAPI), EGFR neutralizing Ab, EGF neutralizing Ab, TGF-α neutralizing Ab, diphenyleneiodonium chloride (DPI), and NG-monoethyl-l-arginine (NMEA) were purchased from Calbiochem (La Jolla, CA). N-propyl gallete (nPG) and allopurinol were obtained from Sigma (St. Louis, MO). Heparin-binding EGF (HB-EGF) neutralizing Ab was obtained from Santa Cruz Biotechnology (Santa Cruz, CA). The following TLR ligands were purchased from Invivogen (San Diego, CA): for TLR1/2, Pam3CSK4 (Pam) is a synthetic tripalmitoylated lipopeptide that mimics the acylated amino terminus of bacterial lipopeptides; for TLR3, polyinosine-polycytidylic acid [poly(I:C)] is a synthetic analog of double-stranded RNA (dsRNA); for TLR5, Salmonella typhimurium flagellin; and for TLR6/2, a synthetic lipoprotein derived from Mycoplasma salivarium 1 (FSL1). To confirm ligand selectivity for each TLR, the addition of TLR neutralizing Abs (0.1 μg/ml, Invivogen) prevented IL-8 production induced by each TLR ligand (data not shown).
Cell culture.
NHBE cells were purchased from Cambrex (Walkersville, MD). Cells were passaged, seeded [in 24-well plates (BD Falcon, Bedford, MA) at 2.0–4.0 × 105 cells/ml], and grown to confluence. Cells were grown in bronchial epithelial growth medium (BEGM; Cambrex) supplemented with defined growth factors contained in the SingleQuot kit (Cambrex) at 37°C in a humidified 5% CO2 water-jacketed incubator. After we established that NHBE cells respond to the various TLR ligands, we used a human pulmonary mucoepidermoid carcinoma cell line, NCI-H292 cells, to further dissect the signaling responses to TLR ligands. NCI-H292 cells were plated at 1.0 × 105 cells/cm2 in 24-well plates (BD Falcon). Cells were grown in RPMI 1640 medium (Cell Culture Facility, University of California-San Francisco) containing 10% FCS, penicillin (100 U/ml), streptomycin (100 μg/ml), and HEPES (25 mM) at 37°C in a humidified 5% CO2 water-jacketed incubator. Because cell lines such as NCI-H292 cells show some variability in their responses to stimuli and inhibitors in different passages (33), all experiments were performed in passages 82-92.
siRNA preparation and transfection of cells.
Predesigned human TACE siRNAs (nos. 104029, 104030, 104031) were purchased from Ambion (Austin, TX). Previous studies in our laboratory showed that siRNA no. 104029 (100 nM) provided the greatest inhibition of TACE gene expression examined by RT-PCR (18, 25) and was therefore used in the present studies (Fig. 4C). The 21-nt sequences for TACE siRNA (no. 104029) are (sense) GGUUUUAAAGGCUAUGGAAtt and (antisense) UUCCAUAGCCUUUAAAACCtg. Predesigned human Duox1 siRNAs (nos. 24873 and 24969) were purchased from Ambion. Previous studies in our laboratory showed that Duox1 siRNA no. 24969 (100 nM) provided the greatest inhibition of Duox1 gene expression examined by RT-PCR (15, 18, 25), and it was therefore used in the present studies (Fig. 7C). The 21-nt sequences of Duox1 siRNA (no. 24969) were (sense) GGACUUAUCCUGGCUA-GAGtt and (antisense) CUCUAGCCAGGAUAAGUCCtg. Silencer Negative Control #1 siRNA (Ambion) was used as a nonspecific siRNA. siRNA transfection into NCI-H292 cells was carried out using Lipofectamine 2000 (Invitrogen, Carlsbad, CA).
Cytotoxicity assay.
For each of the inhibitors examined in this study, we performed dose-response experiments to select an appropriate concentration that showed the most inhibition without evidence of cytotoxicity. Lactate dehydrogenase (LDH) activity in supernatants of cell cultures treated with or without inhibitors was measured with the cytotoxicity detection kit (Roche Diagnostics, Indianapolis, IN) according to the manufacturer's protocol. None of the measurements showed significant cytotoxicity for inhibitors at the concentrations used in the present studies, confirming previous results in our laboratory (15, 18).
Analysis of IL-8 and VEGF protein production.
Cells grown in 24-well plates were serum-starved for 24 h before experiments. Cells were washed three times with serum-free medium and cultured for 24 h with or without inhibitors. Previous studies have shown that the majority of IL-8 and VEGF protein produced is present in cell culture supernatant (6, 18). Therefore, IL-8 and VEGF were measured in cell culture supernatants using an IL-8 or VEGF ELISA kit (R&D Systems, Minneapolis, MN) according to the manufacturer's instructions. For NHBE cell experiments, cell cultures were incubated in BEGM without EGFR ligand(s) for 24 h before experiments and then treated and collected as described for NCI-H292 cells. For siRNA experiments, cells were grown to confluence and treated and collected as described for NCI-H292 cells; to normalize for possible differences in cell number, total protein in cell lysates was measured using the BCA Protein Assay Kit (Pierce Biotechnology, Rockford, IL), and siRNA results were reported as IL-8 or VEGF (nanograms) per total protein (milligrams).
Release of soluble TGF-α.
NCI-H292 cells were cultured in 24-well plates as described above. After reaching confluence, cells were serum-starved for 24 h before stimulation. In these studies, cells were pretreated for 30 min with an EGFR neutralizing Ab (5 μg/ml), which prevents soluble TGF-α from binding to EGFR. An EGFR neutralizing Ab (5 μg/ml) and TLR ligands were added to serum-free medium. After 2 h, cell supernatants were collected, and TGF-α was measured with a TGF-α ELISA kit (Oncogene, San Diego, CA) according to the manufacturer's protocol.
Statistical analysis.
Data are presented as means ± SE. ANOVA was used to determine statistically significant differences (P < 0.05).
Activation of TLRs induces IL-8 and VEGF production via an EGFR signaling cascade in NHBE cells.
We studied TLR2, TLR3, TLR5, and TLR6 because they have the highest expression in airway epithelial cells (24). Here, we show that the addition of TLR1/2 (Pam), TLR3 [poly(I:C)], TLR5 (flagellin), and TLR6/2 (FSL1) ligands all increased IL-8 (Table 1) and VEGF (Table 2) production in NHBE cells. These effects were inhibited by the addition of a selective EGFR tyrosine kinase inhibitor, AG-1478 (10 μM; Tables 1 and 2), indicating that EGFR phosphorylation is required for TLR ligand-induced IL-8 and VEGF production. TAPI (10 μM), a MP inhibitor, also prevented TLR-induced IL-8 (Table 1) and VEGF (Table 2) production in NHBE cells, implicating an MP in this cascade. ROS activate TACE (34), and Nox are known to generate ROS in airway epithelial cells (25). Here, we found that an ROS scavenger [nPG (100 μM)] and a Nox inhibitor [DPI (3.0 μM)] prevented IL-8 (Table 1) and VEGF (Table 2) production induced by activation of the TLR ligands. These results suggest that TLR ligand-induced IL-8 and VEGF production involve a signaling pathway that includes an Nox, ROS, an MP, and EGFR. The following experiments investigate this cascade in detail.
Ligand-dependent EGFR activation and the EGFR ligand TGF-α are involved in TLR ligand-induced IL-8 and VEGF production.
Because NCI-H292 cells have a larger response to TLR ligands (Figs. 1 and 2) and are easier to grow in culture, we used these cells to investigate critical steps in TLR activation. Similar to NHBE cells, treatment of NCI-H292 cells with a selective EGFR tyrosine kinase inhibitor, AG-1478 (10 μM), prevented TLR ligand-induced IL-8 (Fig. 1, A–D) and VEGF (Fig. 2, A–D) production. This effect was not seen with the addition of a selective tyrosine kinase inhibitor of PDGF [AG-1295 (10 μM); data not shown]. EGFR (Erb1) is one of four receptors in the Erb family. To show selectivity for Erb1, we found that the addition of a selective Erb2 inhibitor (AY882) to TLR ligands did not affect IL-8 or VEGF production (data not shown). Treatment of NCI-H292 cells with an EGFR-neutralizing Ab (5 μg/ml), which blocks ligand binding sites on EGFR and inhibits subsequent EGFR phosphorylation, markedly inhibited IL-8 (Fig. 1) and VEGF (Fig. 2) production induced by the TLR ligands, implicating an EGFR ligand-dependent process. Treatment with a TGF-α neutralizing Ab (5 μg/ml) also inhibited TLR ligand-induced IL-8 (Fig. 1) and VEGF (Fig. 2) production, implicating TGF-α in these responses. This inhibition was not seen with the addition of neutralizing Abs (5 μg/ml) to EGF or HB-EGF (data not shown). In addition, measurement of TGF-α released into the cell supernatant showed a significant increase in the presence of TLR ligands compared with control (Fig. 3). These results implicate the EGFR ligand, TGF-α, in TLR-induced IL-8 and VEGF production in NCI-H292 cells.
TACE is the MP involved in TLR ligand-induced IL-8 and VEGF production.
Previous studies reported that the MP TACE cleaves and releases the EGFR proligand TGF-α from the surface of airway epithelial cells, allowing the cleaved ligand to bind to and to phosphorylate EGFR (26). In NHBE cells, TAPI (10 μM), a MP inhibitor with some selectivity for TACE, inhibited IL-8 (Table 1) and VEGF (Table 2) production induced by these TLR ligands significantly. To confirm the role of TACE as the responsible MP, we knocked down TACE expression in an airway epithelial cell line (NCI-H292 cells) using siRNA. TACE siRNA decreased IL-8 (Fig. 4A) and VEGF (Fig. 4B) production significantly in response to multiple TLR ligands. These results implicate TACE in TLR ligand-induced IL-8 and VEGF production in airway epithelial cells.
ROS and Duox1 mediate TLR ligand-induced IL-8 and VEGF production.
ROS activate TACE, and Nox are known to generate ROS in airway epithelial cells by a core component homolog, Duox1 (25). Here, we found that an ROS scavenger [nPG (100 μM)] and a Nox inhibitor [DPI (3.0 μM)] prevented IL-8 and VEGF production induced by these TLR ligands in NHBE (Tables 1 and 2) and in NCI-H292 cells (Figs. 5, A–D, and 6, A–D). To exclude the involvement of other oxidases, we investigated the effect of inhibitors of xanthine oxidases [allopurinol (100 μM)] and nitric oxide synthase (NMEA, 100 μM). These inhibitors had no significant effect on IL-8 (Fig. 5) or on VEGF (Fig. 6) production in response to TLR ligands, implicating Nox in IL-8 and VEGF production induced by multiple TLR ligands. To confirm the role of Duox1, we knocked down Duox1 expression in NCI-H292 cells using siRNA. Duox1 siRNA decreased IL-8 (Fig. 7A) and VEGF (Fig. 7B) production significantly in response to the TLR ligands. These results implicate Duox1 as the Nox that produces ROS in TLR ligand-induced IL-8 and VEGF production. From these results we conclude that these TLR ligands produce IL-8 and VEGF via a Duox1→ ROS→ TACE→ TGF-α→ EGFR phosphorylation pathway (Fig. 8).
TLRs are critical for airway epithelial cell recognition of inhaled pathogens and for innate immune signaling. Activation of EGFRs present on the epithelial cell surface is required for a variety of innate defenses (15, 21, 31, 32). Because TLRs are expressed in airway epithelium and recognize pathogen-associated molecular patterns of various bacteria, viruses, and fungi, we hypothesized that TLR1/2, TLR3, TLR5, and TLR6/2 play roles in EGFR signaling. Here, we show that each of these TLRs communicate with EGFR via a complex, integrated signaling cascade.
First, we found that blockade of EGFR tyrosine kinase phosphorylation inhibited IL-8 and VEGF production induced by TLR ligands, effects not seen with the addition of a selective tyrosine kinase inhibitor of PDGF (data not shown), implicating EGFR phosphorylation in TLR ligand-induced IL-8 and VEGF production. EGFR (Erb1) is one of four receptors in the Erb family. The ligand TGF-α binds to Erb1 and Erb2, and TGF-α is implicated as an EGFR ligand important in IL-8 and VEGF production induced by TLR ligands (as discussed below). The addition of a selective Erb2 inhibitor (AY882) to TLR ligands did not affect IL-8 or VEGF production (data not shown), suggesting that TGF-α binds to Erb1 in airway epithelial cells.
EGFR ligands are known to activate EGFR, resulting in IL-8 (18) and VEGF (6) production. Here, we found that an EGFR neutralizing Ab, which prevents ligands from binding to the EGFR, inhibited TLR ligand-induced IL-8 and VEGF production, implicating ligand-dependent EGFR activation. Previously, we (15, 18, 26) have shown that TGF-α is an important ligand that is cleaved and released from airway epithelial (NCI-H292) cells, allowing it to bind to and to activate EGFR. However, other tissues use different EGFR ligands. In the present studies, treatment with a TGF-α neutralizing Ab inhibited IL-8 and VEGF production induced by TLR ligands in NCI-H292 cells. Furthermore, the TLR ligands caused the release of TGF-α into cell supernatants, confirming that TGF-α release occurred in response to these TLR ligands. These results implicate TGF-α as an important ligand in IL-8 and VEGF production induced by TLR ligands in airway epithelial NCI-H292 cells.
Next, we examined the mechanisms underlying TLR ligand-induced TGF-α release. TACE, "a disintegrin and metalloprotease"-17 (ADAM-17) family member present on the surface of airway epithelial cells, is known to cleave TGF-α proligand and to release soluble TGF-α (4, 20). Addition of TAPI, a somewhat selective inhibitor of TACE, prevented TLR ligand-induced IL-8 and VEGF production in NHBE cells. Because TAPI is not completely specific for TACE, we also examined the effect of siRNA knockdown of TACE on the responses to TLR stimulation in NCI-H292 cells. TACE siRNA prevented IL-8 and VEGF production induced by TLR ligands, implicating TACE as the MP involved in EGFR proligand cleavage.
ROS are known to activate TACE (25), and Nox produce ROS (16). Duox1, a Nox homolog, generates ROS in airway epithelium (25). Here, we show that IL-8 and VEGF production induced by TLR ligands was markedly decreased by Duox1 siRNA. Both a Nox inhibitor and an ROS scavenger prevented IL-8 and VEGF production induced by the TLR ligands in NHBE and in NCI-H292 cells. However, xanthine oxidase inhibitors and nitric oxide synthase inhibitors were without effect. We conclude that Duox1 is involved in TLR ligand-induced generation of ROS. Because a structural interaction between TLR and Nox has been shown (19), future studies are required to investigate the possibility that TLR activation directly activates Duox1 in the airway epithelium.
In summary, the present results show that TLR1/2, TLR3, TLR5, and TLR2/6 ligands produce IL-8 and VEGF in airway epithelial cells via a DUOX1→ ROS→ TACE→ TGF-α→ EGFR phosphorylation pathway (Fig. 8). We suggest that EGFR activation produces IL-8, which causes the recruitment and activation of neutrophils (18). The neutrophils engulf and kill pathogens, adhere to secreted mucins (for which production is also stimulated by EGFR activation; Ref. 31), and are cleared from the airways by mucociliary clearance and by cough. Furthermore, EGFR signaling activates angiogenesis (VEGF) and wound repair, which reconstitutes damaged tissue (6, 15). Other innate immune responses, such as antimicrobial peptides, involve a similar signaling pathway (30, 32).
In humans, 10 functional TLRs recognize microbial components of a variety of pathogens including bacteria, parasites, fungi, and viruses. In airway epithelium, TLR2, TLR3, TLR5, and TLR6 have the highest expression (24). TLR2 is expressed on the epithelial cell surface (1), and our results show that a TLR2 ligand stimulates an epithelial signaling cascade involving EGFR activation that induces IL-8 and VEGF production. TLR2 is a heterodimer with TLR1 and TLR6, and each of these is present on the airway epithelial surface. The ligands used in our experiments stimulate the TLR1/2 and TLR6/2 heterodimers: Pam is a ligand for TLR1/2, and FSL1 stimulates TLR6/2. We confirmed that stimulation of TLR2 alone activates the EGFR cascade by using heat-killed Listeria monocytogenes (data not shown). TLR3, which recognizes dsRNA or synthetic dsRNA [poly(I:C)], is located in endosomes in unstimulated human bronchial epithelial cells (11). However, both viral (10, 13) and bacterial (23) infections, and synthetic dsRNA itself (14), induce epithelial surface expression of TLR3. It is possible that once TLR3 is on the airway epithelial surface, communication with EGFR can occur via a surface signaling cascade. TLR5 is also present on the airway epithelial surface where it can interact with EGFR. TLR signaling has been shown to involve lipid rafts in airway epithelial cells (29), and future studies are needed to investigate the role of lipid rafts in TLR-EGFR communication.
Once TLR ligands stimulate IL-8 and VEGF production via EGFR, downstream signaling may include MAP kinases (22) and NF-κB (3). Here, we studied TLRs that activate both myeloid differentiation factor 88 (MyD88)-dependent and -independent signaling pathways, suggesting that MyD88 is not critical for the TLR-EGFR communication. TLR activation initiates EGFR signaling and other intracellular signaling pathways, including MAP kinases (1). Further study is required to determine whether the two signaling pathways may interact.
These results expand our current understanding of pattern recognition receptors by showing that TLR activation initiates a complex and integrated signaling cascade that activates EGFR. In these experiments, we examined both a permanent epithelial (NCI-H292) cell line and NHBE cells. The TLR ligand-induced IL-8 and VEGF production in NCI-H292 cells was higher than the amounts produced by NHBE cells. Lung epidermoid carcinoma cells constitutively express EGFRs in greater amounts than NHBE cells (12), and we have confirmed that NCI-H292 cells express more EGFR than NHBE cells (data not shown). NCI-H292 cell expression of TLRs is also higher than NHBE cells (9). These differences suggest that normal airways initiate less robust innate immune responses. However, in chronic airway diseases such as asthma, chronic obstructive pulmonary disease, and cystic fibrosis, airway epithelial EGFR expression is increased (2, 5, 7), and it is suggested that exaggerated innate immune responses contribute to the pathophysiology of these diseases (8, 17, 28). Activation of TLRs may provide important defensive responses in the airway epithelium. Because exaggerated innate immune responses may contribute importantly to the pathophysiology of chronic airway diseases, the TLR-EGFR cascade provides potential targets for therapy.
This work was supported by National Heart, Lung, and Blood Institute Grant F32-HL-088822-01 (J. L. Koff) and by the Cardiovascular Research Institute Research and Education Fund (J. A. Nadel).
While this manuscript was under review, Shaykhiev et al. (27) showed that TLR2 and TLR5 activate EGFR in epithelial wound repair.
The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
- Copyright © 2008 the American Physiological Society


text: Hi Group, Does anyone know if winamp is available for the mac and if so, does it work with voice over? Nicole :)> > Click on the link below to go to our homepage. > http://www.icanworkthisthing.com > > Manage your subscription by using the web interface on the link below. > http://www.freelists.org/list/macvoiceover > > Users can subscribe to this list by sending email to > macvoiceover-request@xxxxxxxxxxxxx > with 'subscribe' in the Subject field OR by logging into the Web > interface at http://www.freelists.org/list/macvoiceover >


text:
Free Dental Assisting Test
NOTE- You will be given a Free reference e-book to read which has 178 pages And the test will be based on that e-book.
Who is a Certified Dental Assisting Expert?
A certified dental assisting expert is someone who successfully handled the certification exam designed for aspiring dental assistants and acquired all the skills and knowledge necessary for them to acquire stable and profitable positions in the industry. It should be noted that dental assisting certification holders play major roles and fulfill essential duties in the society. They are responsible in providing assistance to dental operators to ensure that more effective dental treatments are always offered. They prepare patients for the dental treatment, sterilize instruments, pass instruments to dentists when performing a dental procedure, expose dental radiographs, hold suction devices and fabricate provisional crowns. These dental professionals are also responsible in executing laboratory and office duties and providing various kinds of patient care under the supervision of a certified dentist. Among the laboratory and office duties performed by a certified dental assistant are creating cast of mouth and teeth based on the impressions, making temporary crowns, polishing and cleaning removable dental appliances, scheduling and confirming appointments, maintaining records of treatments and receiving patients.
If you want to become a certified expert in this field, then be aware that Brainmeasures can now help you out through its well-developed free dental assisting practice course. Brainmeasures makes it a point to supply those who have enrolled in this free practice course with a free practice test and study guide designed to help them learn the things that they can do to efficiently pass the actual dental assisting certification exam.
Brainmeasures Dental Assisting Practice Certification Course
The free dental assisting certification practice course which is developed by Brainmeasures and is now offered to the public without any cost is the most ideal course for you if your career objectives include working as an effective certified dental assistant. What you will love about this free online certification practice course is its professionally developed and easily understandable free study guide. This study guide will offer you assistance when it comes to learning the usual duties and roles that you need to fulfil and play if you already get the position of a dental assistant. It can help you fully understand all the aspects related to the field so performing all your duties correctly will never become a problem. You will also find the free practice test which is included in the course as impressive because it lets you know what it takes to become a successful passer of the certification exam.
Highlights of the Dental Assisting Practice Certification Course from Brainmeasures
The free dental assisting certification practice course accessible at Brainmeasures is proven to be really beneficial because of its ability to meet your needs to learn more about the scope of work and responsibilities of a dental assistant as well as how you can correctly and effectively perform your duties. The following are just few of the many topics that are included in this free dental assisting practice course:
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The free dental assisting certification practice course offered by Brainmeasures is the perfect certification course for you if your main objective is to work in dental offices after you successfully pass the related dental assisting certification test. It aims to be a huge help for all aspiring and existing certified dental assistants who aim to further improve their knowledge and skills in the dental field so they can improve their ability to offer the best services.
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Expected Salary for Dental Assisting Certification Holders
Passing the dental assisting certification exam can also help you in earning higher. Your received certificate is extremely useful in becoming a certified dental assistant which usually offers you approximately $43,000 to $84,000 annually. If you get the position of a dental assisting consultant upon receiving your certification, then your annual earnings would be in the range of $60,000 to $136,000.
We Guarantee Brainmeasures Practice Courses and Tests are Best
As an ISO 9001-2008 company, Brainmeasures continues to become the leading online skill testing and certification company worldwide. It now offers the most detailed free practice courses and tests designed to help anyone pass and receive their desired certification. Brainmeasures offers practice courses in hundreds of fields, making it a highly reliable company for those who receive a certification in their chosen craft.
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1.Course Material
You will receive course material in a format of an e-book and final certification
exam is entirely based on the provided course material
2.Hard Copy Certificate
On successfully clearing the certification exam you will Get a laminated hard
copy certificate Of your accomplishment depicting your feat, which will be mailed
to your provided address free of cost. Have a look at Hard Copy Certificate
3.Postal charges of hard copy certificate is absolutly free
No extra charges for Postal of the certificate to your place
4.Soft Copy Certificate
You can download the soft copy of your certificate immediately on taking the test
from your individual account.
5.Transcript ID
Using your transcript ID you can showcase your results online to your employer
by just going to Brainmeasures home page, your complete result report will appear.
6.Result Forwarding Facility
Using this feature you can send your scores to your employer and friends by using
through e-mail.


text:
Originally posted by Joecool:
Something to note:
The Vikings have been trailing at halftime in both games against two of the worst teams in the league.
yeah i just read that in the power rankings thread, if we can take advantage of their slow start, that can really play into our advantage, if we capitalize when we have the ball. We can wear them down with the run game in the 2nd half if we can go into the half with the lead and control the clock in the 2nd half and not let them get into sync


text:
Quilt Block Apron
size small adult - page 3 of 3
Page 3: Create Bib Quilt Block
Neck Ties / Quilt Block Ties
5. Fold ties right sides together. With right sides together, sew side seams and one end. Turn right sides out. Baste, serge, or sew across the unfinished edge. Repeat with second tie. Pin the muslin quilt block backing to the quilt block, right sides together, with the two finished neck ties placed inside the two layers (unfinished edge of each tie extending slightly beyond the edge of the quilt block). Place the ties so that their seams are toward one another, rather than to the outside.
The following photo shows the ties pinned onto the right side, top edge of the quilt block back. The quilt block top will be pinned on top as the top layer, right side down.
Sew the backing of the quilt block to the quilt block front along the two sides and across the top that contains the two ties (refer to image below left). Be careful not to catch the ties in the sides of the block. They should be laid out straight so you do not accidentally sew them into any side except at the top.Turn the block right side out, with ties sticking up out of the top. Iron. Refer to the images below.
Skirt/ Waistband
6. Serge or zigzag along both long edges of the waistband. Fold under the two ends and iron. Fold the waistband right side out, lengthwise, and iron.
7. Serge or zig zag across the top of the skirt, the bottom of the skirt (top and bottom are the two long sides) and the top of the towel. Fold under the short sides of the skirt 1/4". Fold under again and stitch along the edge, finishing the sides. Run two gathering stitches along the top edge of the skirt and top edge of the towel. Gather the skirt across the top - adjust so that the skirt width equals the length of the waistband. Gather the top of the towel slightly. Place the towel on the skirt, with the right side of the towel and skirt facing up. Baste the towel into place on the skirt (about 2-3" from the side of the skirt).
Place the quilt block bottom edge along the top edge of the skirt, right sides together. Pin the waistband to the top of the skirt, keeping ends of waistband folded under. The bottom layer is the skirt, the second layer is the towel, the next layer is the quilt block, the top layer is the waistband. Stitch across. Refer to picture.
Finish Waistband / Skirt
8. Fold waistband over top of skirt and pin in place on wrong side of skirt. Hand stitch waistband in place. Refer to images below.
Place the unfinished edges of the waist ties into the waistband open ends so that seams face toward the floor. If ties don't fit into waistband, adjust their width to fit. Machine stitch across ends of waistband catching waist ties.
9. Sew the yellow pocket strip to the top of the blue pocket piece, right sides together to create an outer pocket piece that measures 8" high x 7" wide. Zig zag or serge across bottom edge of outer pocket. Zig zag or serge across bottom edge of pocket lining. Turn under bottom edge of outer pocket front and bottom edge of pocket lining 1/4" and iron. Sew the pocket lining to the pocket front around three unironed sides, right sides together (keep the bottom edge that was folded under open). Turn pocket right side out. Place pocket on skirt. Sew in place along two sides and across bottom folded edges.
10. Hem the bottom of the skirt.
Congratulations! You are finished!
Your next apron will be easier. Remember, it is always easier to make more than one of any item at a time. It goes much faster to make two together, than it does to make one now and one later.
Page 3: Create Bib Quilt Block
Please Share
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All Patterns, images and instructions are copyright protected.
Stitch Glossary
Sewing Book


text:
Suspended membership
Suspended Members
Membership to UEBT is suspended in cases of lack of compliance with the UEBT membership conditions and obligations as detailed in the UEBT – Membership conditions and obligations for Trading Members.
Suspended members lose their statutory voting rights, can no longer use the UEBT membership logo, and risk losing their membership upon decision of the Membership Committee.
Membership is reinstated when members regain compliance with the UEBT Membership conditions and obligations, in which case they recover all their rights.
Current members with suspended membership are:
- ADA – Laboratorio Artesanal Dermofarmaceutico
- Espave
- Inversiones2a
- Productos Alimentarios Misky SAC, Peru
- Solabia Biotecnologica – Unit II


text:
Slide 4 of 5
4. ' "Mad"-ness Returns to the Paley Center'
Now is the chance to meet the owners of Sterling Cooper Draper Pryce. On April 23 at New York City's Paley Center for Media, meet the mastermind behind "Mad Men," Matthew Weiner, along with cast members Jon Hamm, January Jones, and John Slattery, as they provide insight into the hit show; the event will also be live streamed.
Photo Source: AMC
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text:
Kirby Air Ride In The City
Credits & Info
- Uploaded
- Mar 18, 2009 | 9:10 PM EDT
- File Info
- Song
- 2 min 19 sec
- Score
- 4.37 / 5.00
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- Score:
- Rated 4.37 / 5 stars
- Plays & Downloads:
- 7,091 Plays | 563 Downloads
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- Genres:
- Electronic - Video Game
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Author Comments
Rated 5 / 5 stars
The City mode is the meat in the game. I have come up with several ideas for a compact sequel, but I'd beg for a four-player, or even a two-player, run in the City any day. (Oh, I miss that game...)
Excellently nogalstiac (word?) remix of this score!
Rated 4.5 / 5 stars
This is amazing and incredibly nostalgic-- as a kid, all I would do was play the City run, I'd never actually race! I'd play over and over until Dyna Bird would appear, and then I'd battle to the death! Extremely catchy, too. I just think it's missing something, but I can't figure out what, hence the 9. :> great, though.
K, thank you!
Glad you liked it :D
Rated 5 / 5 stars
as garbeld said
it also remnds me of Castlevania, since it has the dark volume in it's sound, but there is n probem in hearing that this is the city trial from kirby air ride, nice job by remaking it, thought i think it would have sounded ebetter if you added a guitar and played it a bit faster, but, thats just mu opinion, you did a great job remaking this song, keep it up!
I've never played Castlevania so I don't if it's like it.
But thanks for the review :)
Rated 4 / 5 stars
I have no doubt that this would be Kirby's theme if Kirby were a Belmont.
And by this music alone I can say that it would be absolutely awesome.
Rated 5 / 5 stars
a good remix.
ive listened to this song more times than days ive lived. and i can honestly say this is a pretty good remix of that song, its alot more intersting and i could still see this playing in the background while i soar around on my dark star. good job!


text:
Craig Garrett
Just bought a B-3 Bomber Jacket from Eastman. Unreal quality. Everything a REAL bomber jacket should be. It turned the heads of everyone who saw it. Worth every penny. It's great knowing that when I'm wearing my Eastman B-3, I'm wearing the BEST!
Chad Jordan
Wanted to buy- Navy N-1 salt water wash size 44. The other one listed for sale is already sold. please let me know if you have one for sale, thank you!
Contact firstname.lastname@example.com
John Lever
RAF Devon fleece size 42/44
mark hillman
Received my buzz tanker jacket and am over the moon with the quality and fit . This is my fifth jacket from eastman and once again exceptional service and a big thankyou to rob for his advice .
Lee Harries
Thanks to Rob & the Team, 'Watch Cap' ...great for the odd frosty morning 10/10
John Lever
Wanted RAF 44 pattern not necessarily Devon fleece,size 44 upwards. Also old type flaky Anj4 size 42.
David Potter
Hello. I'm looking for an Eastman Fliegerjacke, black 48" chest. Good, used condition is acceptable. Please mail me if you can help @ email@example.com.
Matt Ockl
Looking for a B-10 jacket, size 42L or 44.
lee slater
(previous comment)
sorry, a exchange for a eastman b-3 with a chest size of 44-46.
Orlando Herrera Garcia
I would like to trade my 42RAF Air Crew Sweater for a size 44,
Damien Weaver
WTB: Eastman B-15, B-6, or B-3 in size 38. Prefer redskin models on the B-6 and B-3. If anyone's got one they would like to unload, please contact me at firstname.lastname@example.com
John Lever
Looking for a size 42 or 44 Perry Sportswear B3


text:
Firefighters have put out a fire at the Farrel Pomini on West Main Street in Ansonia.
The fire started in the furnace at the back of the building, then quickly spread to the walls, according to fire officials.
"On arrival, they found that the furnace had backfired, which caused the wall and the floor inside the boiler room to catch on fire.(It) blew out a couple of window and the doorway," Ron Burgess, of the Ansonia Fire Department, said.
When the fire department arrived around 7 a.m., heavy black smoke was shooting out of the smokestack. The fire was out within about 20 minutes.
The fire caused a delay in Metro-North service because the fire department had to run a hose across the tracks.
The company's world headquarters are located at 25 Main St. in Ansonia. No one was in the building when the fire started, so there were no injuries.
The 170-year-old company started as a foundry and manufacturer of rubber, according to its Web site.


text: On Thursday, 23 August 2001, at 01:40:12 -0700, David Rees wrote: > Hi, > > I'd like to create an ext2 filesystem over a raw io device, is this even > possible? (If not, skip the rest of this message! ;-) > Maybe I'm completely wrong (as usual :), but as far as I know you can either create a filesystem over any block device (e.g. partition, md, LV, etc.) and use it as usual, or bind a raw device to an existing block device, and let the application (e.g. Oracle) manage space on the device as it wants. Greetings, -- José Luis Domingo López Linux Registered User #189436 Debian GNU/Linux Potato (P166 64 MB RAM) jdomingo EN internautas PUNTO org => ¿ Spam ? Atente a las consecuencias jdomingo AT internautas DOT org => Spam at your own risk


text:
Anne Kingsmill Finch
The Dog And His Master - Poem by Anne Kingsmill Finch
NO better Dog e'er kept his Master's Door
Than honest Snarl, who spar'd nor Rich nor Poor;
But gave the Alarm, when any one drew nigh,
Nor let pretended Friends pass fearless by:
For which reprov'd, as better Fed than Taught,
He rightly thus expostulates the Fault.
To keep the House from Rascals was my Charge;
The Task was great, and the Commission large.
Nor did your Worship e'er declare your Mind,
That to the begging Crew it was confin'd;
Who shrink an Arm, or prop an able Knee,
Or turn up Eyes, till they're not seen, nor see.
To Thieves, who know the Penalty of Stealth,
And fairly stake their Necks against your Wealth,
These are the known Delinquents of the Times,
And Whips and Tyburn. testify their Crimes.
But since to Me there was by Nature lent
An exquisite Discerning by the Scent;
I trace a Flatt'rer, when he fawns and leers,
A rallying Wit, when he commends and jeers:
The greedy Parasite I grudging note,
Who praises the good Bits, that oil his Throat;
I mark the Lady, you so fondly toast,
That plays your Gold, when all her own is lost:
The Knave, who fences your Estate by Law,
Yet still reserves an undermining Flaw.
These and a thousand more, which I cou'd tell,
Provoke my Growling, and offend my Smell.
Topic(s) of this poem: dog
Comments about The Dog And His Master by Anne Kingsmill Finch
Oduro Bright Amoh (11/13/2015 2:44:00 PM)
Man's faithful friend written about so adeptly. Wonderful piece of poetry (Report) Reply
Gangadharan Nair Pulingat (11/13/2015 8:30:00 AM)
A faithful and always loyal to its master, saves the home and life properly from thieves. A powerful poem. (Report) Reply
Ratnakar Mandlik (11/13/2015 2:42:00 AM)
A dog is the most loyal servant and friend of his master. The glorification of this friend in the poem is really touching. Thanks for sharing.10 points. (Report) Reply
Mohammed Asim Nehal (11/13/2015 1:08:00 AM)
A faithful animal, providing services to human in return getting peanuts......Great write. (Report) Reply
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Robert Frost
If You Forget Me
Pablo Neruda
Langston Hughes
Annabel Lee
Edgar Allan Poe
Caged Bird
Maya Angelou
Rudyard Kipling
Stopping By Woods On A Snowy Evening
Robert Frost
I Do Not Love You Except Because I Love You
Pablo Neruda


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The 10-micrometer-long flagellate cell might have a big story to tell about the evolution of eukaryotes.
Fish of Many Colors
January 23, 2014|
Researchers seek insight into the pigmentation patterns of guppies and zebrafish.
January 23, 2014|
Researchers seek insight into the pigmentation patterns of guppies and zebrafish.
January 20, 2014|
The death of a medical worker in China prompts worries that the virus can spread between humans.
January 20, 2014|
Injection of microscopic particles of a plastic-like material protects mice from cardiac tissue damage following heart attack.
January 20, 2014|
Researchers build a device that harvests and stores energy from the mechanical movements of a beating heart.
January 17, 2014|
Patients progressing toward blindness now have better vision after a gene therapy trial.
January 15, 2014|
Illumina says its newest sequencing system can churn out whole human genomes for $1,000 apiece.
January 13, 2014|
Helicobacter pylori strains that share ancestry with their human hosts are less likely to cause severe disease.
January 10, 2014|
Bacterial genes aid tubeworm settling; pigmentation of ancient reptiles; nascent neurons and vertebrate development; exploring simple synapses; slug-inspired surgical glue
January 9, 2014|
A person in Canada has died of the first confirmed human case of H5N1 avian flu in North America.
January 6, 2014|
Researchers find evidence that transposable elements, also known as jumping genes, may contribute to the development of the psychiatric disorder.


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Senate to look into USAID programs
Senate Foreign Relations Committee Chairman Robert Menendez has ordered a comprehensive review of all of USAID's democracy programs, following revelations that the agency engineered a "Cuban Twitter" program.
Menendez asked U.S. Agency for International Development Administrator Rajiv Shah on Thursday to provide his committee with information about all of the democracy programs to measure how the U.S. tries to influence dialogue in countries with limited free speech. The request comes after the Associated Press revealed the agency was running a secretive social network in Cuba called ZunZuneo, whose purpose was aimed at fostering unrest among Cubans toward the Castro regime.
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While the panel chairman did not quibble with the utility of such democracy-building programs like "Cuban Twitter," Menendez (D-N.J.) did want the curtain lifted on the global reach of such programs.
"We are either going to judge whether or not we are going to be supportive of Internet access in the world or not. I think it's consistently unfair that one set of democracy programs has the greatest scrutiny of the federal government to the absence of others," Menendez told Shah at the end of a committee hearing on Thursday morning. "I would ask you to give me information about all of those programs and all of the programming of those programs and all of the tweets and all of the emails and everything so we can make an informed judgment here."
Menendez also said he may request investigations into the projects by the Government Accountability Office or the inspector general overseeing USAID. A spokesman for the agency said last week that a 2013 GAO report found the Cuban social media project to be lawful.
The project in Cuba has drawn increasing scrutiny from lawmakers like Sen. Patrick Leahy (D-Vt.), who called it "dumb, dumb, dumb." Menendez seemed most concerned that the U.S. government does not equally condemn nations around the world for stifling free speech.
"I'm not one to advocate that AID all of a sudden be stripped of its democracy programs," Menendez said. But "those commitments should not be decided by pick[ing] and choosing which country we somehow like and which countries we don't. If they fail to provide their people access to the basic flow of information, it seems to me that we should be pursuing it. So I'd like the information on all the programs."


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text: I was privileged to see Patrick Rafter play the other night in Newport Beach as a member of the Philadelphia Freedoms. I noticed he wasn't using his old Prince Warrior or the Prince Ti Response (the "real" Rafter racquet). He was using a red Dunlop which thanks to some sharp posters in the pro gear section I learned is called the "Volley Graphite Rafter." Seemingly a light stick, not a player racquet at all. I assume he weighted it up, but if not just goes to show how a good player can play with anything. And as fun as it is to watch, the big pressure is not there for WTT tennis. Pat looked really good at times, just like the Rafter we all remember from the US Open and Wimbledon. He clearly was having a good time and won doubles with a fellow Aussie, a journeyman doubles specialist named Josh Eagle. He ended the evening with singles against Ramon Delgado, a player from Paraguay, who I believe is in the top 100. Surprisingly Pat proceeded to lose 13 straight points, losing his serve at love and smiling as Delgado just ripped perfect passing shots for winners. When Rafter finally won a point, he threw his arms up in the air to an ovation from the crowd. He then buckled down as Delgado cooled off a bit and the next few games were very competitive with the server holding. Pat was clearly a bit out of shape, breathing a bit hard and going to the towel between almost every point, even playing around with the very young ball kid who had towel duty. It was in these games that the Rafter of old was seen. It was a pleasure to watch. Followed both serves to net and chipped and charged on Delgado's serve at every opportunity. Still (arguably) the best serve/volley game ever. Both players held from that point on and Rafter had to hold the last game for the team to win the match, which he did. At one point in the match he threw up his toss and caught it and said his well known "sorry, mate" and the crowd cheered wildly. He stayed until every kid's autograph was signed and for pictures with the parents and other adults. A true class act as always. He is missed.


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Hamburg parents discuss intimidation in district
Hamburg Central School District parents, staff, board members and community members spoke of unrest and upheaval, innuendo and intimidation in the district Thursday night.
They also spoke of coming together and solving some of the problems that have seeped from the board room to the hallways to classrooms.
"We can't pit ourselves against each other and change anything or fix anything, but together we can. We need to support one another," said parent Ed Piazza, who led the meeting at Erie 1 BOCES in West Seneca. "Teachers, administrators, the union, need to work together. It's not impossible. It's not crazy. It can happen."
The meeting was organized after a group of community members met with Erie 1 BOCES Superintendent Donald Ogilvie last month to see what could be done about the rocky relations in the district. Leadership on the School Board changed with the May election, the superintendent resigned, and the board, operating with three new members, has tried to govern the district where many do not trust members of different factions.
Teachers say they feel threatened at school, and many community members indicated by raising their hands that they felt intimidated and not free to speak out publicly.
Hamburg Village Mayor Thomas Moses, who has attended many recent board meetings, also spoke at the meeting and collected questionnaires asking what the problems are and how they can be solved. He spoke of being criticized on the Hamburg Educational Ethics Blog, an anonymous blog that posts items and comments about the district and education-related issues.
"We shouldn't be afraid to speak to people," Moses said. "I shouldn't have to put up with that, and nobody should have to put up with that in our district. Nobody. I think the blog should stop."
High School senior Gatlin Walters said it is hypocritical if the rules outlawing cyberbullying for students are not followed by adults, including teachers.
"If New York State passes a law that the schools have to follow, then that law should apply to the adults as well," he said.
Parent Robert Johnstun said he has posted comments on the blog about educational issues using his name, and he has been contacted by parents with similar problems, and has tried to help them.
"There are some benefits that come out of the blog," he said.
But he was in the minority on that view. Some suggested ignoring the blog, but others said it is impossible when comments about children appear. Beth Piazza said her children were threatened on the blog.
"It is affecting children. My children do not want to go to school," she said. "It's more than just a blog . It's more than just ignore it. When the children are involved, I'm not ignoring it any more."
Boston Valley Elementary School Principal James Martinez, who said he was speaking for himself and not as a principal, said he is not intimidated by those who run the blog or who are causing unrest.
"I can't be intimidated," he said. "They tape record, they lie, they give innuendo. They can come after me, I don't care."
Two board members, President David Yoviene and Holly Balaya attended, as did several former board members, including Joan Calkins and Eileen Rucker.
Moses said he has not been proud of the district in recent years. "Somebody said 'You're nuts to get involved.' Well I'm not nuts to get involved, because if we don't get involved, we'll never solve the problem," he said.
Piazza said another meeting to discuss how to improve things will be scheduled and posted on the Hamburg Education Information Facebook page.
email: email@example.com


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The strange case of Iran's centrifuges
Iran suspended uranium enrichment for at least one day in November, a new United Nations report reveals. This was, however, the result of technical problems — not because Iran decided to honor calls to rein in its atomic ambitions.
Still, the news is a surprise, according to the report Tuesday from the U.N. nuclear watchdog. It comes amid speculation about whether sabotage and sanctions are now working against Iran's atomic program and whether serious talks can be kick-started to assuage fears that Iran is working to make nuclear weapons.
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The condition for starting negotiations is that Iran stop uranium enrichment, the process that makes the explosive core of the bomb. Iran has vowed not to halt this strategic work.
The Vienna-based International Atomic Energy Agency's nine-page confidential report describes the suspension in two discrete footnotes. On Nov. 5, the report notes, some 4,800 centrifuges were spinning at Iran's Natanz plant, churning out low-enriched uranium. But "on 16 November 2010, no cascades [of centrifuge] were being fed with" uranium feedstock gas. Then the report states, "On 22 November 2010 [however], Iran informed the agency that 28 cascades were being fed."
This would mean that Iran resumed enrichment with roughly 4,600 centrifuges, out of some 8,400 now installed in Natanz.
IAEA officials gave no explanation for this suspension, but a senior diplomat close to the agency did note that Iran has shut down its centrifuges for short periods of time before, namely "on two or three occasions" since full-scale enrichment began at Natanz in February 2007. The diplomat said the agency could not verify exactly how many centrifuges are turning, since IAEA inspectors did not examine centrifuges one by one, just by cascades of 164 or 174 centrifuges each.
To this unsettling detail was added an expected one. Iran is giving only minimal cooperation under its international obligations for monitoring. When the IAEA asks the Iranians why centrifuges are turned off, their answer is predictable and succinct: None of your business.
One wonders. There have been reports that a computer virus, the Stuxnet, launched by either the United States or Israel, has caused Iranian centrifuges to vibrate out of sync and thus crash. But the head of Iran's atomic energy agency, Ali Akbar Salehi, denied Tuesday that the Stuxnet worm had brought the centrifuges down.
Meanwhile, some analysts wonder whether international sanctions are keeping Iran from getting crucial parts for its centrifuges or whether parts the Iranians have bought abroad were booby-trapped to malfunction — and so cause centrifuge cascades to break down.
Or perhaps Iran has just invested too much in its centrifuge model, the fragile P-1, which is an early design that countries like Pakistan abandoned on their way to building the bomb. Iran may be reining in its P-1 program to clear the way to replace it with a more advanced centrifuge.
The irony is that North Korea has just revealed that it built an enrichment plant outfitted with the advanced centrifuge model known as the P-2. North Korea skipped the P-1 stage entirely, leapfrogging ahead of its ally Iran.


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We just received these great photos that show off the BlackBerry Multimedia Dock! As you can see in the images here on this article this is in fact the OEM dock for the BlackBerry Z10. The dock itself offers two ports on the back one to charge the BlackBerry Z10 and the other is the HDMI output. The email we received stated the dock feels slightly rubberized along with a high gloss slot for the BlackBerry Z10 to slip in and out of it.
Rumor has it the dock will never see the light of day as the BlackBerry Z10 homescreen will not adjust to landscape while in the dock. Now that said if I could get my hands on one of theses bad boys you bet your butt I would use it to the fullest. What about you would you use a dock even if it did not translate into landscape? Check out the images below and let us know what you think in the comments!
Thanks tipster for sending these great images into us!!


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As a lawyer who defends inmates on death row, David Dow confronts death on daily basis. His latest memoir, Things I've Learned from Dying: A Book About Life, is a fiercely honest account of his struggle to make sense of life and death as three important figures in his life each receive their own type of death sentence.
What made you choose to pursue this type of law, especially in Texas, where the death penalty is so prevalent?
I was teaching a class at the law school that had a very, very small part of it that touched on the death penalty, so I learned death penalty law as I was teaching. I thought it would be useful if I met some people on death row. This was 20 years ago, and at that time, death row inmates didn't have the right to be represented by lawyers in their various appeals. A death penalty case has what amounts to three different appeals, two in state court and one in federal court. When I started doing the work, death row inmates had just earned the right to an attorney during their federal court appeal. But they still didn't have a right to an attorney during their state habeus corpus appeal. When I went to see the death row inmates, one was scheduled to be executed two weeks from the day that I met him and hadn't had an appeal because he didn't have a lawyer. I'd never done one of these cases but I agreed to represent him just because I was appalled that the state of Texas was going to execute someone who hadn't had an appeal and didn't have a lawyer. At that time, if you had asked me if I was planning on working on another one, at first I would have said, god no, I'm just going to do this one. But I found the work to be an intellectually and emotionally rewarding experience.
One of the things you do in this book is humanize your clients and allow your readers to empathize with them without necessarily believing that they're innocent of the crimes.
I didn't want to write a polemical book. One of the artifacts of that accidental trajectory of my professional life was that I was not against the death penalty when I became a death penalty lawyer. I wasn't someone who thought we should be executing as many people as we do but I was not somebody who had a deep, moral conviction that the death penalty was wrong. Two things happened to me to convert me into a death penalty opponent: a lawyer story and a human story. The lawyer story is that I realized how the system was actually working. It's just a deeply unjust and unfair system. The lawyer in me found that intolerable. Race plays a role; socioeconomic status plays a role; location where the murder occurs plays a role; identity of the victim plays way too large a role. We shouldn't make a decision based on the victim because it ends up privileging a class that the legal system is not supposed to privilege. But it's really the second thing that happened to me that's more responsive to your question. As a death penalty lawyer, you represent these inmates for a long time, a number of years. Over the course of that representation, you get to know them intimately well. You understand your client as a human being as opposed to what you think a murderer is from reading about one in the newspaper. What I really wanted to do in this book was to write about the inmates on death row in a gradual way, because as a lawyer, you get to know them gradually. I was trying, in the way I developed the narrative, to show in large part the arc that I go through in course of representing one of these guys.
In the introduction, you bring up the debate of the "easier" death (a death row inmate or his victim), something you later touch on with your father-in-law's contemplation of Cormac McCarthy's idea from The Crossing of whether it's worth living your life if you know your fate in advance.
One of things that happens to me frequently when I talk about the last days of my clients' lives, death penalty supporters compare that to the last days of the lives of my clients' victims. They say, "well, as bad as it is as for your clients, the victim had it worse." I just wanted to convey that that might be right, it might be correct, but it's not obviously true. I think there's something to be said for having to focus on what you're going to do between now and the time that you know that you're going to die. They're both terrible and the only idea that I wanted to convey was that it's not obvious which one is more terrible. I was struck by how the same sort of considerations operated in both the case of my client on death row and my father-in-law dying of cancer. They're different contexts, of course, because one person is going to die because he did something "bad" and the other person is going to die because of the sheer bad luck of getting a disease. But at the end of those lives, they're both just human beings who are confronting the same considerations. They're confronting reflections on their life. They're trying to wrap up the relationships with people whom they love. I was very struck by the fact that someone like my father-in-law and a client of mine who'd committed murder had the same emotional path at the end of their lives.
The third piece of the book deals with the loss of your dog, Winona. That was one of the hardest parts to read.
And I found it the hardest part of the book to write. Part of the reason is that it was the most sudden. When somebody dies suddenly, that person might not experience all of the pain experienced by people who die prolonged deaths. But all of the people who love that person who died, they are in exactly the opposite position, emotionally. They haven't had any time to prepare for the loss. In the case of both Peter, my father-in-law, and my client, I had a long time to get ready. And so by the time each of them died, it wasn't a surprise to me, and I didn't feel like there was any unfinished emotional business. Winona's death, on the other hand, was so rapid, her decline was so precipitous, that neither I, nor my wife, nor our son, had the experience of having a dog who gradually got older. Winona got older and then she was gone. To have both her and a with client whom I was unusually close die in such close proximity where, and I don't mean this for to sound at all sanctimonious, I felt somewhat—and maybe even a lot—responsible in both those cases, hit hard. For my father-in-law, I didn't bear any responsibility. He got sick and the responsibility for either doing the right thing or the wrong thing lay with the doctors. It just happened. But with both Winona and my client, I felt responsible. Waterman was my client and when you're a death penalty lawyer and you don't save somebody's life, you always go back and look decisions that you would have made differently. And of course with Winona, I look back at a whole series of decisions and think that if I had made them differently, she may have lived longer.
How do you manage this kind of emotionally taxing work as your "day job" and find the time and energy to write as well?
First of all, thank you for asking me that. I do have a day job but part of my day job is to try and be a writer. I write on a computer that's not attached to the office, that's not connected to the Internet, so that I can't be distracted, though I do have my cell phone next me so that the lawyers I have working for me know that if there's a crisis, they should send me a text. One of, if not the most, important things I was trying to do here was to write about something that every single human being experiences in one way or another. The only piece of the narrative I felt like is an experience that not everyone has is the relationship between myself and my client. The reason I included it is that I wanted to write a book about how, in the face of death of loss, what matters is the death and loss to the person but also to the people who love that person who's dying. What I've learned is that even the most heinous murderers have people who love them. And so what they're experiencing when an execution date gets set, gets closer and closer, and then is ultimately carried out, is—I don't want to say it's exactly the same—not radically different from what somebody who loves a cancer patient who, when the person who loves the cancer patient hears that his or her loved one has three months to live. That was a central idea that was in my brain as I was trying to construct the narrative: the loss that people feel is related to the love and relationship they have with the person who's dying. From the point of view of the people who are losing someone they love, the biography of the person they're losing explains why they love that person but it isn't relevant beyond that.


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HELSINKI, Finland -- Anna-Karin Kammerling of Sweden became the first double winner at the European Swimming Championships, taking the 50-meter butterfly, while Alexander Popov beat the meet record in the 100 freestyle semifinals Tuesday.
Kammerling was timed in 26.40 seconds. Karen Egdal of Denmark was runner-up at 26.97 and Martina Moravcova of Slovakia third at 26.98.
''It always feels good to win, but I'm not pleased with my time,'' said Kammerling, who swam on the winning women's 400 freestyle relay team Monday.
Popov topped the semifinalists in the 100, powering to a 48.34 time in his heat. The Russian's time was .13 seconds faster than the previous championship record, set by Pieter van den Hoogenband of the Netherlands last year.
The 100 freestyle final is Wednesday. Popov, who swam the anchor leg on Russia's championship team in the men's 400 freestyle relay Monday, also holds the world record of 48.21, set in 1994.
Jere Hard won Finland's first gold medal, beating Lars Frolander of Sweden by .08 seconds in the men's 50 butterfly.
Hard's winning time was 23.88, only .28 off the world record set by Geoff Huegill of Australia six weeks ago.
The closest finish of the day came in the men's 100 breaststroke final, with only .05 seconds separating winner Domenico Fioravanti of Italy and runner-up Jarno Pihlava of Finland. Fioravanti's time was 1:02.02.
After getting two silver medals Monday, Romania struck gold by winning the women's 800 freestyle relay final at 8:03.17. Italy was a distant second at 8:08.14.
The women's 200 backstroke was won by Nina Zhivanevskaya of Russia at 2:09.53, ahead of Romania's Diana Mocanu (2:11.62).
David Ortega of Spain was the other race winner Tuesday, swimming 55.50 in the men's 100 backstroke.
Germany's only gold of the day came in the men's 3-meter synchronized diving event, Tobias Schellenberg and Andreas Wels combining for 331.98 points.
Unfortunately for the winners, they won't compete at the Summer Olympics after failing in the German trials.
In the only women's diving final, Russia's Vera Ilyina finished far ahead (275.28 points to 256.83) of Heike Fischer of Germany in the one-meter springboard.
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Thoughts are in my mind right now. Thoughts about writing this comment in particular.
-Deadpool- wrote:
Crunchyroll was kinda better 5 years ago
No its always been this bad. Don't you love it though?
How boring this is
I need more time.
I apologize in advance for late responses and dropped conversations.
My cat keeps staring at me. I wonder if he realized I am not his real master..
Upload me into your brain.
I use to try to get my friends to come over every weekend, but as we start to get older things like jobs and girls and what not have changed the game. It went from being fun to see them and plan out things to being a struggle to even work out a time to chill weeks in advance. I've honestly started to just give up. I'm the friend who ended up the odd one out ya know? I was never good with their friends or at making my own, and women tend to not pay me any thought. After middle school we ended up going to different schools and even though it seemed like a huge gap between us we still managed to stick together and hang out...for a while. I don't know if this is part of growing up or I'm just clingy to the only people i ever considered friends, or maybe i never even tried hard enough, but i never thought things would turn out like this. I used to be the overconfident big guy of the group when we were little, always acting big and being careless of others. They would always hang out with me back then, every day. We would walk during recess in grade school and just talk, we would actually end up on the other side of the school without noticing it because we were so focused on what we were talking about! Around six grade is where it started going south i guess, not instantly though, but slowly. I was coping with my parents divorce by acting out and what not and my friends had started smoking weed around the same time. By middle school they had started acting different and i started being self conscious due to my eating habits which resulted from my parents divorce as a coping mechanism. With my friends hanging out with their "smoking buddies" from what I could only guess them to be now, i started hanging out by myself, in the library or in some secluded place. I didn't understand what the hell was going on back then, all i knew was i was scared and alone and my friends had picked other people over me. When they did hang out with me i was happy, but by the eighth grade they only seemed to do it out of obligation due to our long history. Also by the eighth grade i had been spending my summers at my dads for a few years, mostly behind a computer screen the entire time, so my social skills had slowly dwindled. So by 9th grade i was alone, going into high school by myself(they went to a different one), and had such little people skills that, by the third month i had barely talked to anyone. I did still hang out with my friends after school, rarely though. At my new school i made friends among some odd folks including otakus, a large girl with anger and daddy issues,and two guys who later turned out to be gay(unbeknownst to me). They were odd but they were friends and i was content for a while. Eventually though i screwed up somewhere due to my parents battles that used me as a catalyst, so i lost them as well. the year that followed that i had dated one of the girls i hung out with(not the big one) and then halfway through the year broke up with. I was so starved for communication by the third year of high school i would text her without her knowing it was me (or so i thought) just so i could talk to somebody,er well text. Soon she revealed she knew it was me and i could tell she still had feelings for me. Unfortunately by this point i had gotten so fed up with my situation that i couldn't even bring myself to like a girl who was more or less the only person who really had any idea of who i was. So i just told her some random garbage about not liking her and using her to get some info on someone else so she would move on from me and date someone better. As for my original friends, we talk, and every once in a while they come over, but the gap had only widened between us. I find myself quite alone in the end as this final year begins. Every summer I've spent alone, school has become a bitter reminder of what i lost, and my family is so consumed with itself i cant even truly bring myself to care anymore. To be honest i think i would rather be truly alone from the start then had to go through the pain of losing everything. Its not like i tried to distance myself from everyone, its not like i didn't try to be with them, I did, but i never saw them hold out a single hand to me, not a single word spoken that showed i was their friend. no one calls me and say "hey i got some free time wanna chill?" no one comes to my house just for the sake of saying hi. Still i suppose if i try harder and throw away any resentment i have that maybe i could still have friends. Maybe this life still has more to offer, after all I'm only 17, i still have time. But i hate to leave my childhood saying "thank god that's finally over" ya know? I wish i could at least manage to make all these bad things lead up to something good at the end. My life isn't terrible, my family is caring in ways and my friends do still consider me a friend, but why do i always feel like I'm getting the short end of the stick? In the end i know its probably my own fault. I got scared, or i failed to handle the situation properly, but after so long you just start losing momentum. Sorry for the long rant.
Kickin' It In That Place Between The Couch Cushions!
whether i'll pass my driving test tomorrow or not! :O
If I'm online...I'm probably bored.
Whether or not to randomly shout out pancakes right now.
a Otaku
enjoy every moment with friends :-)
whether I'll survive the deadline on sept 9
I'm sad to say goodbye to august! Goodbye to holidays!!!
Baby your the best
That's the way the cookie crumbles. Time to move on now...
A monkey with two cymbals.
Now give me your peaches you little toad.
Beer beer beer beer beer beer beer beer beer beer...Ah, finally, a beer!
The same thing we do every night, Pinky...
''I'm supposed to meet up with someone but I'm feeling too lazy to go out.''
Burned Out Meter: Anime at 80% - Manga at 95% - Video Games at 2%


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7 Duke of Westminster
Landowner, 60
In the great Monopoly game of life, the player who's been dealt the best cards is Gerald Grosvenor. He owns not just Mayfair and Park Lane, but substantial amounts of Belgravia, too. The most recent annual report for the Grosvenor Group shows that it made pre-tax profits of £394.8 million, and had property assets worth £5.46 billion. All from 300 acres of land which came into the family around 1677, and was mainly swamp. Far from being known as the cruel-hearted squire, though, the Duke has a reputation for taking an interest in the community, not just the cash. When Waitrose got permission to open a branch in Knightsbridge, they were forbidden to sell newspapers and greetings cards. This was in case it affected the newsagent's business just up the road.