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High Dose Chemo With Stem Cell Transplant as Treatment for Multiple Sclerosis That Failed Prior Treatment
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|Multiple Sclerosis
|Drug: Alemtuzumab Drug: Fludarabine Drug: Cyclophosphamide
|Phase 2
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|A Phase II Study of High Dose Chemotherapy With Autologous Hematopoietic Progenitor Cell Transplant for Multiple Sclerosis That Failed at Least Two Lines of Therapy
- To evaluate the toxicity of autologous HPC transplant in patients with multiple sclerosis that have failed at least two lines of disease modifier therapy [ Time Frame: At 5 years post transplant ]All follow-up appointments will be carried out at Texas Oncology-Amarillo Cancer Center. Patients will be monitored for clinical toxicities and using laboratory blood tests for renal functions, hepatic functions, and bone marrow functions at At discharge post-transplant, then again at 6 weeks, 3 months, 6 months, 9 months, 12 months and after that 6 monthly until death..
- To evaluate the effectiveness of high dose chemotherapy with HPC transplant for multiple sclerosis sclerosis that has failed at least two lines of therapy [ Time Frame: Assessed at baseline, tat 3 months, 6 months, 9 months, 12 months, and then after every 12 months until death ]hen rechecked Neurologic evaluations will be carried out in the offices of the two neurology co-Investigators and the information provided to the transplant physicians for record. Patient will also undergo a repeat MRI scan at 3 months, 6 months, 9 months, 12 months, and then after every 12 months until death, after the transplant to evaluate changes in the number of MS plaques. Subsequent MRI scan will be determined by the patient's neurologist as is needed clinically.
|Study Start Date:
|November 2012
|Study Completion Date:
|November 2013
|Primary Completion Date:
|November 2013 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Single Arm
Conditioning regimens with Alemtuzumab, Fludarabine, and Cyclophosphamide will be used for all patients.
Drug: Alemtuzumab
Alemtuzumab 10 mg given IV on day 1 of the 5 day conditional regimenDrug: Fludarabine
Fludarabine 25mg/m2 daily given IV on days 1-5 of the 5 day conditioning regimenDrug: Cyclophosphamide
Cyclophosphamide is given 3 gm/m2 for mobilization, and then repeated during 5 day conditioning regimen w/ doses of 50mg/kg/day on days 1-4
Detailed Description:
Multiple sclerosis is an inflammatory autoimmune disease characterized by loss of myelin and axonal damage, having typical contrast-enhanced MRI foci as an imaging counterpart. MS shows three main patterns of clinical course: relapsing/remitting, primary progressive and secondary progressive.Concerning disease pattern, secondary progressive is the standard indication, to avoid overtreatment in relapsing/remitting patients or ineffectual treatment in primary relapsing patients.
Currently, MS is the most common autoimmune disease that have been treated with autologous HPC transplants (Fagius et al, 2009; Burt et al, 2009; Saccardi et al, 2006). More than 350 consecutive cases have been reported by the EBMT over the last decade. Most patients who underwent autologous HPC transplant for MS in the early studies had secondary progressive MS, and relatively fewer had relapsing remitting disease, with a Kurtzke Expanded Disability Status Scale (EDSS) of 3.0-9.5 at the time of transplant. Significant objective and subjective improvements have been reported in up to 70% of these patients.
The following conditioning regimens will be used, with Alemtuzumab, Fludarabine, and Cyclophosphamide will be used for all patients. Prophylaxis of Acyclovir, Levaquin, and Fluconazole will be given to prevent infections. The autologous HPC will be infused within 48-72 hours of completing the chemotherapy. The patients will receive additional supportive care medications and treatments as necessary. Neutrophil engraftment will be defined as the day on which the ANC rises to > 500 cells/ml for two consecutive days. Platelet engraftment will be defined as the first day on which the platelet count rises to > 20,000/ml over a 7-day interval without transfusion support.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years to 60 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
Age between 18-60, inclusive
Patients carry a diagnosis of multiple sclerosis, according to the McDonald's criteria for diagnosis (Polman et al, 2011).
Must have a neurologist providing the primary care for the MS and be willing to be evaluated for the multiple sclerosis by the two neurologists who are the co-investigators in the protocol.
Must be documented to be HIV negative.
An EDSS of 3.5 - 5.5
Patients must be able to give written consent.
Inflammatory disease despite primary disease modifying therapy with at least 6 months of interferon and another disease modifying therapy, including fingolimod,glativamir, natalizumab, and mitoxantrone. Failure is defined as two or more clinical relapses with documented neurologic changes (excluding sensory changes) within the year prior to the study. (NOTE: Relapses must have required treatment with corticosteroids). Failure may also be defined as one relapse (excluding sensory changes) treated with methylprednisone and, on a separate occasion within the previous 12 months, evidence of active inflammation (i.e. gadolinium enhancement on MRI scan of the CNS).
No previous history of allergic reaction to cyclophosphamide, G-CSF or mesna
Patients must not be pregnant
Failure to accept or comprehend irreversible sterility as a potential side effect of therapy.
Life expectancy of more than 6 months
No evidence of myelodysplastic syndrome on peripheral blood smear
Not allergic to cyclophosphamide, mesna, fludarabine or alemtuzumab
Baseline serum creatinine must be <1.5 mg/dL, left ventricular ejection fraction >55%, adequate pulmonary functions (oxygen saturation at room air of >90%), and AST and ALT not > 2x upper limits of normal, and no history of previous or active malignancy, except for localized cutaneous basal or squamous cell carcinoma in situ of the cervix.
Exclusion Criteria:
Diagnosis of primary progressive MS.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01679041
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01679041
|United States, Texas
|Amarillo Diagnostic Clinic
|Amarillo, Texas, United States, 79106
|Dr Ruby Saulog
|Amarillo, Texas, United States, 79106
|Texas Oncology
|Amarillo, Texas, United States, 79106
|Principal Investigator:
|Seah Lim, MD
|Texas Oncology
|Responsible Party:
|Seah Lim M.D., Sponsor-Principal Investigator (MD), Texas Oncology Cancer Center
|ClinicalTrials.gov Identifier:
|NCT01679041 History of Changes
|Other Study ID Numbers:
|First Submitted:
|August 29, 2012
|First Posted:
|September 5, 2012
|Last Update Posted:
|November 25, 2013
|Last Verified:
|November 2013
Additional relevant MeSH terms:
Multiple Sclerosis
Pathologic Processes
Demyelinating Autoimmune Diseases, CNS
Autoimmune Diseases of the Nervous System
Nervous System Diseases
Demyelinating Diseases
Autoimmune Diseases
Immune System Diseases
Fludarabine phosphate
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
Antirheumatic Agents
Antineoplastic Agents, Alkylating
Alkylating Agents
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents
Myeloablative Agonists
Antimetabolites, Antineoplastic


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Rémy Martin reasoned not everyone has the means to visit them in France so they've brought the heart of Cognac experience to Canada.
The pop-up cellar installed in a former yoga studio at 155 Liberty St. in Toronto runs Wednesday to Saturday until Nov. 3 then disappears — likely forever. What had been a studio has been cleverly redesigned into three spaces: a bar, lab-like tasting/blending room and atmospheric aging cellar complete with oak barrels. The evening starts with a Rémy Martin cocktail — a choice of a sidecar, old fashioned or spicy toddy. Then into the blending room to taste four-, eight- and 14-year-old Rémy, and try to formulate the correct blend to make Rémy V.S.O.P. Two lucky guessers who are the most accurate win a small oak barrel to take home for aging their own brandy.
The cellar room is next on the agenda for a taste of Coeur de Cognac and XO drawn with a pipette out of the barrel. Participation in this "educational" experience is free (with a suggested donation to prostate cancer research) to the first 800 drinking-age consumers who sign up. So far more than half the available spots are taken so hit the link fast if you're thirsty for knowledge. (remymartinexperience.ca)

subset: commoncrawl


text: Supporting Technologies WaterSolve LLC WaterSolve LLC provides a full service solution in dewatering operations by combining highly technical environmental remediation treatment products and services for customized client solutions. This full service concept has given WaterSolve a national reputation as a leader in dewatering operations. WaterSolve's Chemical Control & Tracking System (CCTS) is designed and built to efficiently feed chemicals for dewatering applications. The system optimizes the application of chemical by automatically adjusting the feed rates based on variations in slurry line flow rate and in-line solids concentration. The system also provides documentation and tracking of several applicable parameters. For a brochure about the CCTS system, please click here. The professional staff of engineers and technicians at WaterSolve work with clients from project concept through completion and tailor the solution to meet the client's project objectives. This objective upholds WaterSolve's higher purpose to help the environment and sustain one of Earth's greatest resources…water! Click here to read more about the partnership between TenCate and WaterSolve For more information, visit http://gowatersolve.com Smartfeed® Chemical Conditioning Systems Each SmartFeed® application uses laboratory test methods to custom-tailor a chemical conditioning program to the slurry or sludge at a project site. Your project's real world processing conditions are measured by SmartFeed®. The SmartFeed® system tests flow, density, percent solids, pH and conductivity every 15 seconds, ensuring your slurry receives the proper dosing. Water discharge is tested in real time for pH, TSS , Ntus & PAHs to ensure project permits are met and supported by electronic records. Smartfeed® provides printable mass-balance reports for each TenCate Geotube® in your project. These reports show total flow and dry mass for comparisons against laboratory test projections of tube area used, chemical program usage rate and water quality during full-scale operations. The SmartFeed® system was built to serve projects where performance cannot be sacrificed. SmartFeed is a best management practices (BMP) tool to reduce stakeholder concerns on project performance, and contributes to the overall improvement of project quality. For more information, visit http://www.smartfeedsystem.com


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Gary A. Baker brings a unique perspective to the Board as both a URI engineer and as a technology professional with broad international experience. After receiving his undergraduate degree in Mechanical Engineering and Applied Mathematics from URI in 1988, for the first phase of his career, Gary worked at Texas Instruments in various design engineering roles. In recognition of his technical achievements, Gary was elected Senior Member, Technical Staff in 1994, recognition only awarded to the top 5% of the TI technical community. Products designed by Gary and his teams have been produced in the hundreds of millions of units and his work has been recognized with the award of 11 US patents. Continuing with TI into the late '90's, Gary made the transition to marketing and business development, earning a MBA from Columbia in 2001. Gary's tenure with TI concluded in 2006 with the spin-out of Sensata from TI. At that time, having completed an expat assignment in Shanghai, Gary returned to the US to lead the business development activities of the newly formed Sensata Technologies. Gary currently serves as Vice President, Business Development, and is based in Attleboro, MA. He is a member of Tau Beta Pi, the national engineering honor society and Beta Gamma Sigma, the international honor society recognizing achievement in business programs.
Gary Baker
Copyright © 2017 University of Rhode Island.


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New York State Senate Announces Earth Day Contest
Statewide Earth Day Poster Contest Promotes Environmental Awareness
OLEAN – Senator Catharine Young (R,C,I- Olean) today called for local student entries for the New York State Senate's Earth Day Poster Contest, a statewide competition that encourages student awareness of environmental issues.
To celebrate and honor Earth Day this year, the New York State Senate is sponsoring a poster contest for children in grades K – 6. The theme of our Earth Day celebration is "Reduce, Reuse, Recycle." The winning posters will be displayed on Senator Young's website, and the participants will receive a certificate acknowledging their participation. Schools wishing to participate in this year's event must submit their entry by April 5, 2013 via the Senator's website: www.young.nysenate.gov.
Students are encouraged not only to be creative in their project, but also to convey a real commitment to making the environment a better place. By educating students about the importance of recycling, they will learn to be creative in solving the problem of solid waste.
The New York State Senate takes this opportunity to celebrate the great strides New York has made in helping to improve our environment.
Since the first Earth Day was celebrated in 1970, over 20 million Americans have participated, helping to improve the quality of air we breathe and the water we drink. In addition, landmark legislation has been passed to help support this effort, such as the Clean Air Act, Clean Water Act and the Endangered Species Act.


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Re: Suggestion for SVN Documentation
From: Ryan Schmidt <subversion-2009a_at_ryandesign.com>
Date: Mon, 19 Jan 2009 18:03:08 -0600
On Jan 19, 2009, at 14:22, Rez wrote:
> I have a few suggestions and not sure if this is the right forum to
Neon is a library for connecting to WebDAV servers. Subversion can
SWIG, the Simplified Wrapper and Interface Generator, creates the
Book feedback is best sent to the book's mailing list. See the
To unsubscribe from this discussion, e-mail: [users-unsubscribe_at_subversion.tigris.org].
This is an archived mail posted to the Subversion Users mailing list.


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Round three of the 2015 Formula 1 calendar is here, and Shanghai's International Circuit is playing host to it. The fans from all around the world always look forward to the racing in China, thanks to the track at Shanghai, being overtaking friendly and challenging for the drivers in general.
But, the race this weekend at the smoggy atmosphere of Shanghai will particularly be interesting because of what happened a fortnight ago in Sepang. As Sebastian Vettel clinched his 40th win in Malaysia, he comprehensively defeated both Mercedes in a straight fight to the flag. That means, this weekend, all eyes will be on Mercedes, and how they cope with the Ferrari and Vettel attack.
Still, are many more things to look out for during the Grand Prix this weekend, and we have made a list of the 10 most important ones.


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South Tama County High P B I S Students of the Month
February 22, 2017 Thayne Lamb, Senior- Parents: Matthew & Darcy Lamb- Activities Involved In: Band, Choir, Plays, Musicals, Large Group Speech, Individual Speech, Thespian Society, National Honor Society, and Tennis. more »»
South Tama High students take on the "Real World"
February 21, 2017 Being backstage for a Broadway production, observing a morgue, riding with a police officer in a police car, and doing medical research with the FDA might seem unrelated, but they actually have... more »»
Marshalltown Community College Foundation seeking scholarship applications
February 20, 2017 MARSHALLTOWN – The Marshalltown Community College Foundation is currently accepting scholarship applications for the 2017-18 academic year. more »»
South Tama School Board Reviews State Report Card
February 16, 2017 South Tama School Board members reviewed the recently released Iowa Schools Report Card during a work session on Monday, Feb. more »»
South Tama Middle school - 2nd Quater perfect attendance
February 15, 2017 5th grade Anaya, Enrique Backen, Nicholas Bear, Macael Blocker, Avery Dolash, Jeramy Frakes, Mary Kate Gunderson, Daena Haughey, Adam Hernandez, Jorge Homrighausen, Kacie Jefferson, Millie Keenan,... more »»
Great Backyard Bird Count at Otter Creek Lake Sat/. Feb. 18
February 15, 2017 Enjoy a morning of bird watching while you participate in some citizen science at Otter Creek Lake & Park on Saturday, Feb. 18, from 10 a.m.- noon. more »»
Madisen Hinegardner accepted to Wartburg College Teacher Education Program
February 15, 2017 WAVERLY, IA Madisen Hinegardner has been accepted into the Wartburg College Teacher Education Program. more »»
Jim the Wonder Dog premiers today
February 15, 2017 The new serial- Jim the Wonder Dog - begins today - Friday, Oct. 17, in The Tama New-Heral. more »»
Helping you help your family choose healthy habits series offered
February 14, 2017 Want to learn how to make healthy meals in a hurry? Need help making money last? Need help keeping calm in chaos? Making family wellness a priority is difficult when trying to balance busy... more »»
South Tama Middle School students of the month
February 14, 2017 BiographiesBy: Melanie Alonso, Shayla Behounek, Raymond Behrends, Leila Ellis, Erik Delgadillo, Zeara Kapayou, Kelsey Culbertson, Jesus Cervantes Freddy Avila (5th) Congratulations to Freddy Avila... more »»
Tama Soil-Water announces Grocery Sack Contest
February 13, 2017 To help spread the message of Soil and Water Stewardship Week, April 30 through May 7, Tama Soil & Water Conservation District will be holding its annual Grocery Sack Contes. more »»
Video tour of Iowa Judicial Branch Building is now featured online
February 11, 2017 DES?MOINES- Discover some of the special features in the Iowa Judicial Branch Building and the interesting stories behind them by watching a new video tour online, and then come and see the building... more »»
Morningside College awards degrees to Raue and Moran
February 11, 2017 SIOUX CITY- - Forty-five Morningside College students graduated with bachelor's degrees and an additional 72 students graduated with Master of Arts in Teaching degrees in December. more »»
Joe Scharnweber receives degree from the University of Iowa
February 10, 2017 IOWA CITY- Joe Scharnweber, Tama. received a BM-Music degree from the University of Iowa at the close of the fall 2016 semester. more »»
Clancy on Des Moines Area Comm. College Dean's List
February 9, 2017 Des Moines Area Community College President Rob Denson recently released the names of students eligible for the Fall Semester Dean's List. To be eligible, a student must have earned a 3.5 to 3. more »»
Gladbrook-Reinbeck possible schools dissolution before South Tama Board
February 7, 2017 The Gladbrook-Reinbeck School Board was presented with a 2nd petition for dissolution and have requested a statement from the South Tama School Board outlining their willingness or unwillingness to... more »»
Childrens, eucators author at South Tama Elementary
February 7, 2017 Julia Cook and dog Kirby hold presentations at the STC Elementary on Friday, Jan. 27. more »»
Iowa State announces 2016 fall semester Dean's List
February 7, 2017 AMES- Approximately 8,775 Iowa State University students have been recognized for outstanding academic achievement by being named to the Fall Semester 2016 Dean's List. more »»
STC Board votes continuation of Instructional Support Program
February 6, 2017 On Monday night, Jan. 23, the South Tama School Board held a public hearing for a proposal to consider continued participation in the Instructional Support Program. more »»
Hawkeye Community College Announces Fall Dean's List
February 6, 2017 WATERLOO-Hawkeye Community College announces the Dean's List for the Fall Semester. The Dean's List is official recognition of outstanding academic accomplishment by full-time students. more »»
News, Blogs & Events Web


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Harrison Ford Was A Carpenter Before He Was An Actor – Knightlines 8/9/13
IT'S THE WEEKEND! Finally! Here we go with the Friday August 9th edition of Knightlines with celebrity gossip and things you might not have known...
1. 30% of women think that putting on their makeup is the most important thing they do all day.
2. Bing Crosby's real first name was Harry.
3. Harrison Ford was a carpenter before becoming an actor.
4. Indian Packing Company of Green Bay, Wisconsin, in 1919 donated $500 for uniforms, plus the use of its athletic field for team practice to their namesake Green Bay Packers.
5. A group of crocodiles in water is called a float. The same group of crocodiles on land is called a bask.
6. 76-percent of women and only 46% of men make their bed every day.
7. In 1885 pharmacist Charles Alderton of Waco, Texas, introduce the soft drink Dr. Pepper)
8. One in five single men say they haven't done cooked a meal in over a year.
9. The frog, which can't chew its food or use its tongue to get food down its throat. Instead, the frog's eyes sink down to the roof of mouth to help push the meal into its stomach.


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What is BIS?? (this is not a sales pitch, you need to know how to explain your program to potential employers)
-ASU's BIS program is one of the TOP 5 IDS programs in the US. BIS (Bachelor of Interdisciplinary Studies) is a university-wide program intended for the student who has academic interests that might not be satisfied within existing disciplinary fields. BIS students create specialized interdisciplinary degrees to prepare themselves for careers in a world that increasingly bridges academic disciplines. Students choose two concentration areas (or one double concentration) representing academic interests they wish to integrate. BIS students also complete four core courses to acquire the intellectual tools needed to identify connections between their academic interests and engage in interdisciplinary problem solving.
Thursday, January 21, 2010
From my BIS class
Posted by Vicki Nicole at 10:28 AM
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Scripts››Magento,Photo SharingClone Script
About Magento
Magento is the eCommerce software and platform trusted by the world.
FMEExtensions offers Magento Product Image Gallery. This Photo Gallery Module contributes effectively in promotion of your product on your website. You can advertise your Products wonderfully in front of your customers by using Product images. You can upload images for any blog you want.


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Send a message explaining your needs and David will reply soon.
Response time: 48 minutes
Yeshiva University (Chemistry)
My name is David. I graduated from Yeshiva University with high honors in chemistry. I have been tutoring for over 4 years in chemistry, biology, math, physics, and MCAT prep. I have taken the MCAT and scored in the 85th percentile. I have worked with students from elementary math to students preparing for medical school admissions test. I have worked with all ages and all skill levels. I am a firm believer that student are able to learn anything they set their minds to as long as they have the right study skills. I will work hard with you or your children to help them excel and reach their goals in life.
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I have worked with students for the past several years on the proper way to study for a Regents exam. The Regents exams are meant to stress the students. I will work extremely hard to have your children excel with their exam. I have worked with many students taking many different regents, ranging from biology, chemistry, algebra I and II, to English, physical science, as well as many others. My students will excel if they put in the time and effort. I also graduated from Yeshiva University with high honors in chemistry.
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I find the hardest accomplishment for students is learning the proper way to study. I have worked many years tutoring students and teaching them the proper way to study. While working with kaplan for over two years teaching MCAT, I have stressed training students learn the correct way to study. Learning the correct way to study will make all the difference in a students development. I have worked hard to help students break bad study habits throughout the past few years


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Roseanne Bartley is a jewellery designer with a distinctive sense of civic responsibly – not as a recent development in her practice but something I have observed throughout her career. She is a designer that sees jewellery making as a refection of our humanity and our relationship to one another, environment and place.
Born in New Zealand and living in Melbourne, Bartley graduated in Fine Arts (Gold and Silversmithing) from the Royal Melbourne Institute of Technology in 1991. Her practice has always had a conscience. Questioning the notion of jewellery as adornment or as a form of personal expression has always been a fundamental premise to her work.
Her practice has a conceptual base developed from her ideas about what jewellery is, to why and how we make it. This has immersed her deeply into the theories and philosophies of design critics and practitioners from the ideas of Husserl on materiality to the study of phenomenology (otherwise described as the science of consciousness and our interactions with the world) to those of Deleuze and Guattari.
It is complex yet logical to ask questions about what we do, how and why. Making jewellery is an interaction after all, a communication with one another. But what are we trying to say? Bartley tackles this along with the questions 'what makes us design', 'what do we say about culture and society' and for 'what purpose'? In asking these questions can we understand our material culture and the practice of making jewellery.
Her research has led her to explore our reactions to her pieces as in 'Culturing the body', the performative pieces 'Link, link, link' and the 'Human Necklace', Barcelona 2006, that describe the meaning behind the practice of forming 'links' both physically and metaphorically.
Today her work has become more focused on what the work reveals about ourselves as a collective, and of a place and time. It is inevitable that within the current turn of events her focus has switched to an ecological and environmental awareness. But will jewellery save the world? D*Hub had the opportunity to catch up with Bartley this week.
Do you feel different from other jewellery designers and in what way?
Hm, interesting question I think I would have to say yes and no. I am still concerned with many of the things that jewellery designers do but in recent years I have been more inclined to make jewellery led experiences than a jewellery product. So if I were to define the difference I would say I work with the medium rather than within it.
Did you ever think you would become a student of philosophy when you started out and what value has it been to your work and how has it changed your practice?
Hah, very nice to be considered as a student of philosophy but if I am, I don't think I am a very good one. I'm always messing up my quotes or forgetting my references. Having said that I do read theory and non-fiction (my favourite time to read such text is around a fire whilst camping somewhere remote – relaxed, less distracted by noise) I think it's really important for an artist to read and listen to good radio – perhaps not at the same time. I read to inform my practice, social anthropologists such as Tim Ingold and David Turnbill, craft/art theorists Glenn Adamson and Joanna Drucker are all very accessible and have been particularly influential in my thinking about practice.
Have you felt there has been something lacking in the way we think of jewellery design? When you teach what do you try to instill in your students to approach jewellery design of in their future?
Phew this is a big question, but in short yes I do. I am not so interested in making jewellery as a product or accessory. In my own work I explore the relationship of jewellery to culture and therefore I encourage the students I work with and to think more expansively about what jewellery is and what it can do.
Civic Responsibility also is an integral part of your work. What has this added to your work?
Jewellery is often thought of as an accessory, something we accessorize with, we see something ourselves in a piece of jewellery and wearing it signifies something of our lack – or at least that is how the key theory of jewellery goes. However I would say this understanding, or positioning of jewellery, is only ever about confirming identity and limits the potential of jewellery. I like a challenge so I took this theory of jewellery as a provocation and tried to find other modalities to activate jewellery.
So rather than uphold the studio jewellery model (working indoors removed from the environment in which I collected material from), I began to work outside and invited people into the process so that I could be more engaged with and by the world around me. For 'Seeding the Cloud' I also made a booklet of instructions so that others could share in the process.
Who are the designers that you admire and why?
I'd have to say Benjamin Lignel, Manon Van Kouswijk and Susan Cohn because they all work jewellery with an engaging and expansive vision.
You spent some time in Barcelona in 2006 where you did performative work that engaged the community. How would you describe your experience there?
I also visited Barcelona last year, this time only for four days but in that time I managed to do another work that held significance for me. So I have begun thinking of Barcelona as my muse. I find the city and its people very inspiring. My experience is informed by walking and observing the streets. The architecture is very rich, lots of physical and metaphysical layers, and the community inhabits public space (for meeting friends, dancing, festive occasions) quite differently to my own street. I know a few people who live in Barcelona and they help with any translation and I find making my work there is a great way to engage people who I might not ordinarily meet.
You are now doing work that addresses the issue of waste (Seeding the Cloud). What drew you/ inspired you to broach this environmental issue through your work?
Years ago I heard Tim Flannery, when he was Australian of the year, speaking of the radio about global warming. He promoted some fairly extraordinary scientific solutions one of them propelling sulfur into the atmosphere. I was equally impressed as I was horrified (an effect I am sure Tim was aiming for), but it made me think about the my knowledge base and I began to ask myself what sort of solution could I come up with? Idealistic, ambitious! Yep I know, but what I noticed about Flannery's scientific solutions was they assumed a universal solution; intrusive globalized human intervention was the answer! There was no people power, no local knowledge no neighbourhood action, no valuing of what currently exists (maybe it's too late for that!) which I think are important to activating any social change and that's were I felt my area of expertise had an edge! Jewellery is personal, it also works on an interpersonal, social and cultural level, it's aligned with the experience of preciousness and beauty, small in scale and rich in detail and so on. These conditions of jewellery are what I began to analyse and think about how I could activate them and once I had established that I started to invite people into the process.
Tell us about the relationship between walking and your jewellery pieces. Are the end pieces artworks, jewellery pieces or something more and what do they say about us?
Walking, collecting, making work outdoors is a way of working, it's a process that both informs and leads to the creation of my work. 'Seeding the Cloud', is one example of how I work with this process. In one sense it's a kind of cartographic trace of the body in time and space. I walk and work for the distance of a thread, when laid out, the interconnected threading of matter can be understood as a mapping, while when it is gathered up, it can be quite satisfyingly work on the body.
How long have you been working with discarded materials now? Will you continue using them and perhaps you could tell us about what you will be doing in the future?
I have been working with found object for at least 15 years in some capacity or another. Over the last 5 years I have been working more specifically with found plastic. For my latest work I am taking a short break from looking out into the world and I have been looking back in time to the origins of jewellery. I am using similar making processes but I felt I needed to understand jewellery as one of the first cultural expressions so that I might continue to find alternate ways of working with the medium.
You have stated that jewellery design will not save the world however I'm going beyond the spectrum of jewellery design now. Do you think that the way we design, if all designers put their civic responsibility cap on like yourself, that design / designers could save the world?
Who knows, but it's worth a try!
Bartley will be running Seeding the Cloud: A walking work in process at Gaffa Gallery.
Find out more about 'Seeding the Cloud' in her blog here.


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szólj hozzá: France 2-4 Germany
The Germans who had huffed and puffed their way against Canada and Nigeria finally showed their class in the much anticipated final group encounter against Les Bleus. Sylvia Nied opted to open with Ilka Grings and Fatmire Bajmaraj. It was Kristin Garefrekes who got them on the frontfoot with her header with Grings following suit to put Germany two up.
After the half the French fought back with Marie-Laure Delie rising up near post to meet a corner to cut the lead down. But 10 minutes later came the turning point as Berengere Sapowicz, the French goalie scythed down Bajmaraj after she was sprung free by Grings. The Finnish referee Kirsi Heikkinen had no hesitation sending off Sapowicz and pointing to the spot. Up stepped Grings and she made no mistake against Sapowicz's replacement Celine Deville. 3-1 up and a win but certain.
Their opponents were not done yet however as Laura Georges again exposed Germany's weakness on set pieces with her thumping header. But towards the end fatigue set in and they failed to clear a cross which fell to Celia Okoyino Da Mbabi who swung it into goal.
So far Birgit Prinz has been a non-factor and it remains to be seen whether Nied will turn to her to pull a rabbit out of the hat if required. So far Germany have done well with their deep bench. But now comes the knock out stage with the competition getting tougher and Prinz's experience might prove attractive.


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• 'Read to me' – automatically reads the text on each page
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This colourful fun book is recommended for children ages 3-5.
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text: hi everyone, people who have read my post under journal and photos would know that I recently got a new cuttle and has been feeding already. but today after it has eaten for bout 15-30 mins or so it started swimming all over the tank almost non stop, I am worried that it may get too tired but doing this and idea why is my cuttle doing this??? Thanks! :D


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DJ/producer Marc Kinchen, aka MK, aka the 4th Measure Man, has been topping charts since the early '90s with his signature vocal house tracks and remixes for artists including Betty Boo and Celine Dion. Though he is mostly known as a house producer, Kinchen has also shaped the dark sounds of New York garage, and most recently produced three tracks for Latin pop kingpin Pitbull. He recently spoke to us about the rise of the house sound in mainstream music, and playing alongside his brother, Scotti Deep. They will headline Public Works this Saturday with Todd Edwards.
What is the biggest change you've seen in house music since you started producing in the early '90s?
The biggest change is really how the actual music is made now because of technology. You can make music on your iPad now. In 2011, we have more tools to do cool complex stuff that would have been really hard to do in the '90s, and even just five or 10 years ago. The fact that kids can do this so easily in their bedrooms is a big change. Everyone is wireless. I can make a track in the studio, on the beach, or sitting in traffic in L.A. Truly anyone can do a mashup, a remix, or an original production now.
You also said that making music for you is "more just a feeling, so [you] just go for it and hopefully it ends up working." Is your production style the same as it was when you first started?
It's still the same today, but it's even easier with today's technologies because I can get it done a lot faster. It's like art in a way, except instead of seeing something in my head for a canvas, I hear the ideas in my head and try to put them down in the way that I imagined.
What do you think about house being a prominent presence in hip-hop, pop, dubstep, and almost all genres lately?
I knew it was coming. I am kind of surprised that it took this long. Everything seems to go in cycles, and it's especially true with music. I am also a true believer that things of quality and appeal never really go away. With the help of the Internet and social media, a new generation of kids and new people can rediscover old music and make it new again every day. My remix of "Push the Feeling On" was the hook and backing track for Pitbull's hit "Hotel Room Service." There is a new artist coming out of London that is using another one of my songs as the main hook for their new song called "Got Me Burning." I guess people really like the sound that I am known for.
You produce a variety of genres, including vocal house and Latin pop. Where does that versatility come from?
Most people know me as MK the house producer. But I am just a producer at heart, and I love to produce all types of music, whether it's four-on-the-floor, Latin pop, dubstep, R&B, or soul. Music is music, and if it appeals to me I am happy to jump in. I do love Latin music and reggaeton and moombahton, too.


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NEW DELHI: Wondering whether the ban on over 10-year-old diesel vehicles will improve air quality in the national capital, top carmaker Maruti Suzuki's Chairman R C Bhargava has said the industry would certainly be hit hard by it.
He also questioned whether it is fair to around 2 lakh car owners, affected by the ban, to be told without hearing them that their "asset has just become scrap".
Bhargava asserted that cars contributed only 2.2 per cent of the overall air pollution in DELHI as per the scientifically collected data analysed by the IIT Kanpur.
"This ban on diesel cars, at least I can't see how it will make any measurable difference in air quality in Delhi but it will certainly hurt industry more than that," Bhargava told PTI here.
He said that around 2 lakh car owners, who would be impacted by the order in the Capital, had done nothing wrong and complied with the law while buying these vehicles.
"Suddenly they find without being heard that there asset has just become scrap. I don't know how far that is fair, how far that is justified as far as those people are concerned. It is (vehicles) their means of livelihood, it is their means of going to their business," Bhargava said.


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Martha E Franks
Found 10 Records, 9 Photos and 1,855,720 Family Trees
Born in Tyler, West Virginia, USA on 2 Jul 1847. Martha E married Martin Luther Gorrell and had 7 children. She passed away on 6 Jun 1922 in Pleasants, West Virginia, USA.
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text: > but something must be wrong because in backports there is no new version > of gnome-volume-manager which depends on hal This is the stock version and gnome-volume-control isn't being removed because of udev or hal. Some kde component is removing it, that's fine with me. > If if misunderstood something feel free to correct me, but I think there > must be a newer version of hal. Not that I can find. Thanks Kate > >Thank you Frank > > > >On Tuesday 14 March 2006 10:38 am, Frank Küster wrote: > >>Kate Draven <firstname.lastname@example.com> wrote: > >>>Its seems like a bad idea to have hal, hal device manager. and udev > >>>removed, or hal, hal device manage and hotplug with a udev upgrade. > >> > >>AFAIK, current udev replaces hotplug, and this has nothing to do with > >>KDE. The same may be true for hal, but I never installed it. > >> > >>Regards, Frank


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Action Quotes and Sayings
The key to success is waking up and stop dreaming and chase your dreams.
Effective action is always unjust.
– Maya Angelou
Forgiveness is the key to action and freedom.
– Hannah Arendt
I say that justice is truth in action.
– Benjamin Disraeli
The time for action is now. It's never too late to do something.
– Antoine de Saint- Exupery
Action speaks louder than words but not nearly as often.
– Mark Twain
All action results from thought, so it is thoughts that matter.
– Sai Baba
All men of action are dreamers.
– James Huneker
Action is the real measure of intelligence.
– Napoleon Hill
"I must do something" always solves more problems than "Something must be done."
Your beliefs don't make you a better person, your behavior does.
In the end, people should be judged by their actions, since in the end, it was actions that defined everyone.
– Nicholas Sparks
Action always beats intention.
The day you decide to do it is your lucky day.
– Japanese Proverb
People may doubt what you say but they will always believe what you do.


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Sure, the broad textures were there, thanks mainly to the multi-instrumental wizardry of Thomas Frasier Scott and Dave Newhouse, who both play a wide variety of woodwind instruments and keyboards, but gone was the more avant edge, replaced instead by a more approachable sound that was still no less challenging or complex. The reunited Muffins, also including founding member Billy Swann on bass and drummer Paul Sears who, while not an original member was part of the lineup that recorded their classic albums Manna/Mirage and <185>, may be less quirky, but their influences run as wide as ever on the captivating Double Negative.
Over the course of seventeen compositions, the Muffins, augmented by guests including Sun Ra Arkestra members Marshall Allen and Knoel Scott on saxophones, as well as trombonist Doug Elliott and a string section that includes violinist Amy Taylor, violist Kristin Snyder and cellists Laura Dent and Okorie Johnson, create a sound that draws from Henry Cow on "Writing Blind," skewed soul on "Choombachang," Emerson, Lake and Palmer on "The Ugly Buttling" and Van Der Graaf Generator on the anthemic "The Man in the Skin Painted Suit," without being directly imitative. The Muffins lack the bombast and melodrama of some of the progressive groups that are their progenitors and favour a more relaxed approach.
That's not to say there aren't moments of chaos and rapid shifts in time and feel. "Angel from Lebanon" starts lyrically enough, but soon segues into a section that revolves around a foreboding bass ostinato over which dissonant piano chords and outré horns build to a dark intensity before moving into a keyboard solo that hearkens back to Soft Machine and, to some extent, National Health.
Tracks including "5:00 Shadow," featuring some fine improvisation by Allen, Scott and Elliott, show a looser improvisational approach, as does the free jazz of "Metropolis." "Dawning Star" feels like a more assertive play on Brian Eno's ambient music, while "They Come on Unknown Nights" represents a skewed chamber music.
The question, after 78 minutes of varying moods, colours, rhythms and harmonies that range from the melodious to the oblique is this: does it hang together as a focused piece of music? The answer is an undeniable yes. Stylistically schizophrenic though the Muffins may be, they have devoted a significant amount of time sequencing the compositions, painting a broader picture; there's a clear arc here that, when taken as whole, tells its story through its very diversity. Double Negative lays waste to claims that progressive rock is inherently anachronistic. With a wealth of ideas executed with a large palette the Muffins show that it is not only alive, but moving forward.
Visit the Muffins on the web.
Track Listing: The Highlands; Writing Blind; Choombachang; The Ugly Buttling; The Man in the Skin-Painted Suit; Childhood's End; Exquisite Corpse; They Come on Unknown Nights; Cat's Game; Stethorus Punctum; Dawning Star; 5:00 Shadow; Meteropolis; Angel from Lebanon; Frozen Charlotte; Maya; The Two Georges
Personnel: Thomas Frasier Scott (alto and soprano sax, flute, clarinet, alto clarinet, keyboards, percussion, programming), Dave Newhouse (keyboards, baritone and tenor sax, bass clarinet, flute, flarinette), Billy Swann (bass, acoustic guitar), Paul Sears (drums, electric guitar)
With Sun Ra Arkestra guests: Marshall Allen (alto sax on "5:00 Shadow," "Metrolpolis"), Knoel Scott (alto sax on "Choombachang," "5:00 Shadow," "Metropolis," "Dawning Star," baritone sax on "5:00 Shadow")
and: Doug Elliot (trombone on "Writing Blind," "Choombachang," "Exquisite Corpse," "5:00 Shadow," "Metropolis," "Angel From Lebanon," "Frozen Charlotte," "The Two Georges"), Amy Taylor (violin on "The Ugly Buttling," "Childhood's End," "Exquisite Corpse," "They Come on Unknown Nights," "Dawning Star," "Frozen Charlotte"), Kristin Snyder (viola on "The Ugly Buttling," "Childhood's End," "They Come on Unknown Nights," "Dawning Star," "Frozen Charlotte"), Laura Dent (cello on "The Ugly Buttling," "Childhood's End," "They Come on Unknown Nights," "Dawning Star"), Okorie Johnson (cello on "The Ugly Buttling," "Childhood's End," "They Come on Unknown Nights," "Dawning Star," "Frozen Charlotte"), Janusch (Czech speaking voice on "Exquisite Corpse")
Title: Double Negative | Year Released: 2004 | Record Label: Cuneiform Records
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|How America Unsexes the Asian Male
By David Mura
The New York Times
August 22, 1996
The Japanese-American actor Marc Hayashi once said to me: "Every culture needs its eunuchs. And we're it. Asian-American men are the eunuchs of America." I felt an instant shock of recognition.
To my chagrin, I came close to being one such eunuch on screen in the Coen brothers' movie "Fargo."
The call for the role seemed perfect: a Japanese-American man, in his late 30's, a bit portly, who speaks with a Minnesota accent.
I am a sansei, a third-generation Japanese-American. I've lived in Minnesota for 20 years. Though not portly, I'm not thin. A writer and a performance artist, I had done one small film for PBS.
After I passed the first two readings, my wife and I talked about what other parts might follow and even joked about moving to Hollywood. But in the end, the Coens found another Asian-American actor.
But when I saw the much acclaimed "Fargo", I said to myself, "Thank God I didn't get the part". The character I would have played is Mike Yanagita, a Japanese-American who speaks with a thick Minnesota accent and awkwardly attempts a pass at old high school friend, Marge Gunderson, a rural police chief who is visibly pregnant.
He then tells of marrying a mutual acquaintance from high school and of her recent death from cancer. A few scenes later, Marge learns that this marriage was fiction: the acquaintance is now only alive, but has also complained to the police that Mike has been harassing her.
The Japanese-American character has no relevance to Marge's investigation. He is there mainly for humor. The humor is based on his derangement that Marge or their acquaintance would ever find him attractive.
I recognized this character as only the latest in a long line of Asian and Asian-American male nerds. Often, as in "Fargo" such a character will pant after white women, ridiculous in his desires. In the movies, as in the culture as a whole, Asian-American men seem to have no sexual clout. Or sexual presence.
Americans rarely talk about race and sex together. It's still taboo. Yet, I often wonder what people make of me and my wife, who is three quarters WASP and one-quarter Hungarian Jew. Recently we went shopping with my sister Linda and our children. Several people, all white, mistook Linda for the wife, the mother. Was that because many whites find it difficult to picture an Asian-American man with a white woman?
In fiction, when East meets West, it is almost always a Western man meeting an Asian woman. There is constant reinforcement for the image of the East as feminine and the stereotype of Asian women as exotic, submissive and sensual. From "Madame Butterfly" to the "The Karate Kid", Part II" and "Miss Saigon," the white man who falls in love with an Asian woman has been used to proffer the view that racial barriers cannot block the heart's affections.
But such pairings simply place white men at the screen's center and reinforce a hierarchy of power and sexual attractiveness. They play on the stereotype of the East as feminine. And where does that leave Asian men?
A salient feature of the play "M. Butterfly" is that it affirms this feminine view of Asian men. In it, a French diplomat conducts a lengthy love affair with someone he believes is a woman but is actually a Chinese transvestite. The affair proves that Asian manhood is indeed difficult to find, at least for white Westerners. And when the "mistress" strips to a highly buffed and masculine body, it is not just the diplomat who gasps, but the audience as well.
And the stereotypes continue. In the sitcom "All-American Girl," Margaret Cho played a hip Korean-American who dated white boys in defiance of her mother's wishes. The brother was a studious, obsequious geek who dated no one.
Asian and Asian-American men are simply not seen as attractive or sexual beings by the mainstream culture. What could be attractive about the horny, thick-glassed, nerdy Asian guy, ridiculous in his desires for white women?
How little things change. As a boy I watched Mickey Rooney as the Japanese buffoon neighbour in "Breakfast at Tiffany's" and knew I never wanted to be associated with this snarling, bucktoothed creature who shouted at Audrey Hepburn, "Miss Gorrightry, Miss Gorrightry," and panted when she offered to let him photograph her; I identified with a John Wayne against the Japs; in "Have Gun Will Travel", I was a cowboy like Paladin, not the Chinese messenger who ran into the hotel lobbying shouting, "Terragram for Mr. Paradin."
To me as a child, Asian features, Asian accents---these were all undesirable. They weren't part of my image of a real all-American boy.
For a while this seemed to work. My parents, interned during World War II, wanted to distance themselves from their ethnic roots. We lived in all-white suburb, where I generally felt like one of the crowd. Then came adolescence, and my first boy-girl party. As usual, I was the only Asian-American and person of color in the room. But when we began to play spin the bottle, I felt a new sense of difference from the others. And then the bottle I'd spun pointed to a girl I had a crush on, and she refused to kiss me.
Did that have to do with race? I had no language to express how race factored into the way the others perceived me, nor did they. But if the culture had told me Asian men were nerds or goofy houseboys, the white kids at the party must have received the same message.
In college, in the early 1970's, my reaction to the sexual place assigned to me took the form of compulsive sexuality: rampant promiscuity with white women and an obsession with pornography. There was definitely a racial component to it: my desires focused specifically on white women. I thought if I was with a white women, then I would be as "good" as a white guy.
It took me years to figure out what was going on. It helped to read Frantz Fanon, the great Caribbean author and psychiatrist. In "Black Skin, White Masks," he writes of how the black man who constantly sleeps with white women has the illusion that his feelings of inferiority will somehow be erased by this act.
Gradually, I began to ask questions about how I learned what was sexually attractive and what images the culture gave me of myself.
How, for instance, does race factor in attraction? A popular way around such questions is to say that love sees no color.
I don't believe that. We are taught to see and process race early on. Race may not be the sole determinant in interracial relationships, but it is a factor. When I look at my wife, for example, I'm aware my desires for her cannot be separated from the ways the culture has inculcated me with standards of white beauty.
And when I told Alexs Pate, an African-American novelist, about Marc Hayashi's comments about the eunuchization of Asian-American men, he replied, "And black men are the sexual demons."
One is undersexed, the other, oversexed. Everyone knows who possesses a normal, healthy sense of sexuality.
Recently, after a panel discussion on "identity art," an elderly white man came up and complimented me on a performance I'd appeared in with my friend Alexs. Then he asked, "Weren't you in Fargo, too?"
"No," I replied. "That wasn't me."
David Mura is the author of "Turning Japanese" (Anchor, 1991) and "Where the Body Meets Memory: An Odyssey of Race, Sexuality and identity" (Anchor, 1996). Quote this article on your site
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Beaker! Swedish Chef!
Printable View
Beaker! Swedish Chef!
Well I did house chores and ordered dinner during the first hour, but I caught Melissa's and Roshon's dances. :lol Roshon almost didn't roll Chelsie all the way over his back!
On the alcohol front, I just opened up a bottle of cabernet. It has a cap, but I hear that's actually becoming a trend these days in finer wines. Honest!
As a very recent college grad and penny-pincher, I love me some cheap wine/booze. Just don't bring any cheap beer near me. My Wisconsin roots don't allow for that.
Tonight even wine in a box is acceptable!
I need to through the first elimination before I go to the booze. I don't want to overdo it in case I don't have to.
Here comes the plug for Duets


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It's World Book Day today, but the last thing you need to read (ha!) is another tedious article about how The Dirt is great (and Nikki Sixx has shat all over its legacy with the nonsense that is The Heroin Diaries, FYI) or how insightful the now 15-years-out-of-date The Long Hard Road Out Of Hell is. No, we harangued the TH editorial team for our picks of slightly less obvious picks.
Top 6 Books about ROCK that aren't the bleeding obvious choices
1) Precious Metal: Decibel Presents the Stories Behind 25 Extreme Metal Masterpieces – edited by Albert Mundrian
Decibel Magazine's Hall Of Fame series of articles might not do anything particularly new – each month the series details the creative process that went into creating a classic album – but the method of delivery quite frankly shits all over anything any magazine on this side if the Atlantic had tried to do with the same concept. While other mags filter the facts through journalistic inadequacy, Precious Metal presents the stories of classic albums as told through oral histories provided by the musicians involved in their creation. Even when there have been splits of the most acrimonious kinds within bands, Decibel have sought out every member to get a complete picture (the chapter on Jane Doe where they talk with ousted Furber guitarist, Aaron Dalbec, is a perfect case in point, and is absolutely fascinating). Precious Metal collects 25 of the best of these columns (including one on Darkthrone's Transilvanian Hunger that has never been printed anywhere else) and provides fascinating insights into some of the albums that have changed all our lives.
2) The Philosophy of Punk: More Than Noise! – Craig O'Hara
Punk is probably the most fluid concept in the field of "rock" music, existing as not just an incredibly elastic genre (All Time Low at one end, Dead Kennedys at another, and so on). Even leaving aside the wide scope of what "punk" music is, the culture that surrounds the concept is even broader – that's why there have been so many bloody books on the subject of punk culture. Among the best, recommended by our man of letters, Mr Tom Doyle, is The Philosophy of Punk. Covering everything from fanzines to how punk is presented in the mainstream, from skinheads to homosexuality, The Philosophy of Punk leaves virtually no stone unturned in its analysis and assessment of the spheres of culture that punk has either spearheaded, or found its way into through some form of cultural osmosis or another. And yeah, even though has a chapter on Straight Edge (and goodness knows, the world doesn't need yet another load of words committed to paper on that little sub-section of punk), it's still a broad and engaging view on so many aspects of the ephemera and cultural overspill that punk has had in the last 30 years that make The Philosophy of Punk a worthy purchase.
3) Metallica: This Monster Lives – Joe Berlinger with Greg Milner
We've all seen Some Kind of Monster, right? We all sat there, squirming as we watched Metallica go through those bum-clenchingly embarrassing group therapy sessions, and those even more bum-clenchingly embarrassing group recording sessions for St Anger. We all had a chortle whenever we saw Kirk Hammett riding about on his horse, and full-on laughed out loud at those scenes where Lars Ulrich met up with Dave Mustaine, and it looked like MegaDave was about to burst into tears at any moment. Metallica: This Monster Lives tells the story of the documentary from the perspective of the filmmakers behind it. It's interesting to read a book on one of the world's biggest bands that doesn't cloak its subject with excessive praise, or try to cover up their flaws with platitudes or excuses. You've seen the film – you know that Berliner and Milner aren't about to go out of their way to present a rose-tinted view of the world's biggest metal band.
Hell, it's worth if for the chapters where they talk about crybaby MegaDave alone. Go and read it and you'll see what we mean.
4) Our Band Could Be Your Life: Scenes from the American Indie Underground 1981-1991 – Michael Azerrad
It's a solid truth that the impact of a band within rock music cannot be measured by their record sales alone. You only have to look at the NWOBHM bands that Metallica (yep, them again) cite as their early influences – bands that've sold less records than Lars Ulrich has had drumming lessons – to see proof that a band's influence. Our Band Could Be Your Life: Scenes from the American Indie Underground 1981-1991 (try saying that three times in quick succession) chronicles the careers of thirteen bands that at least some of should be familiar to most Thrash Hits readers (Black Flag, Minutemen, Mission of Burma, Minor Threat, Husker Du, The Replacements, Sonic Youth, Butthole Surfers, Big Black, Dinosaur Jr., Fugazi, Mudhoney, Beat Happening), all of whom helped define the sound of…well, of damn near ever punk, hardcore, post-hardcore, and damn will a load of other subgenres that are around today. Go learn yourself some history.
5) The Story of The Streets – Mike Skinner
Yeah, this isn't a book about metal, even if it does contain anecdotes about how an encounter with Black Sabbath's flight cases while on work experience at Steel Pulse's studio in Birmingham taught Mike Skinner an important truth about the music industry, and just what it is about Tom Morello's guitar technique that Mike Skinner loves so much. Even if you can't stand Mike Skinner's music, his autobiography is a brutal assessment of his career both personally and professionally, and well worth reading by anyone who has even a passing interest in the realities of the music industry today. Skinner is one of the rare musicians able to offer the perspective of someone who enjoyed success in the industry during the last glory days of mad advances and huge record sales, but also as one that carved out an effective niche for being a working musician in the Internet age. Skinner covers his mental illness, substance abuse, and industry excess with sometimes excruciating honesty, whilst simultaneously providing an eloquent artist's perspective on some of the more "business" parts of the music industry: the refocussing of the industry on live music revenues as opposed to recorded revenue, the breakdown of just where all the money goes, and how musicians need to adapt to be successful now nobody buys albums anymore. What's more, his insightful assessment into the creative process and just why making a second album (or in Skinner's case, his third) is much more complicated than the oft-repeated (but rarely true) adage that "you've got your whole life to write your first album, but just a year to write your second", is by far one of the greatest bits of writing on the subject of the mechanics of songwriting you're likely to read in a book not specifically aimed at being about songwriting. So yeah, it's not metal, but it sure as shit is about rock'n'roll.
6) Birth School Metallica Death – Paul Brannigan and Ian Winwood
We've talked about the books of former-Kerrang! editor, Paul Brannigan, several times before – check out this interview we did with him just last year about his Dave Grohl biography, This Is A Call. We've not even sure we're supposed to know about this yet, but right now Paul's working on a book about Metallica (yes, them again) with former Kerrang! colleague Ian Winwood . If his previous work is anything to go by, it's going to be a corker. And yeah, so it isn't available to buy yet, but we've just given you five other books to get your teeth into – finish all of those and then come back and give us grief for previewing a forthcoming release for our sixth choice.
Now get thee to a library. Reading Ist Krieg, ETC.


text:
proteins found in the cell membrane.
Discussion of all aspects of cellular structure, physiology and communication.
Moderator: BioTeam
4 posts • Page 1 of 1
proteins found in the cell membrane.
What are the three proteins found in the cell mebranes, and what is the function of each?
i need some help.
alright i read my notes my teacher gave and can't find it anywhere with the internet
1.why are spindle fibers important
2.sister chromatids and centromeres make up what
3.what phase follows telophase (i think it's cytokinesis)
4.what effect on the cell would there be if the s phase is not functioning properly
5.compare cytokinesis in an animal cell and a plant cell
6.compare cell division in a prokaryote and a eukaryote
and that's all the ones i have thank you : )
Re: proteins found in the cell membrane.
there are actually five proteins throughout the cell membrane:
1. carrier proteins- bind w/ molecules and carry them across the cell membrane (in/out of membrane)
2.glycoproteins- have sugars attached to them
3.channel proteins- allow molecules to pass freely through membrane
4.receptor proteins- bind w/ proteins on surface of cell to influence its metabolic rate
5.enzyme proteins- help carry out metabolic reactions in cell
Re: proteins found in the cell membrane.
I was always taught there are 6 fundamental membrane proteins.
1. Carrier proteins (Facilitative, active, aquaporins etc)
2. Enzyme proteins (Integral and peripheral)
3. Signal transduction proteins (hormone reception, coat proteins?)
4. Cell recognition (Here's your glycoproteins)
5. Intercellular joining (Your junction proteins)
6. Attachment to the Extracellular matrix and cytoskeleton. (All your stabilizing proteins, microfilaments, intermediate, and microtubules.)
*scratches head* Transport, signal, and stabilizers?
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City and Borough of Juneau
How Do I...Get a Burn Permit Apply to Volunteer Request Sharps Pickup
CCFR MenuHomepage Contact Us About CCF/R Officers Stations
Fire Marshal's OfficeFire Marshal Office
News and MediaDaily Incident Reports Subscribe to CCFR News Subscribe to CCFR DIR News Archive
Capital City Fire/Rescue
Suspicious Vehicle Fire 6-17-2011
On Friday June 17, 2011 at approximately 2:10 a.m., Capital City Fire Rescue responded to 1501 5th Street in Douglas for a vehicle fire. Upon arrival, fire personnel found a Ford Ranger pickup truck fully engulfed in flames. The truck was approximately ten feet away from the residence. There were no injuries and the truck was a total loss. This fire is being investigated as a suspicious fire by the Capital City Fire Marshal's Office and the Juneau Police Department. Anyone with information about this fire is encouraged to contact the Fire Marshal's Office at 586-5322 or the Juneau Police Department. Submitted by Fire Marshal Daniel M. Jager


text:
Chemistry 109/University of Phoenix
A marine biologist may need to dive deep underwater for her research. To do so, she may want to know how to do calculations related to pressure and volume changes that occur, depending on the depth of the dive. Suppose she inhales air at a depth of 60 meters and at a pressure of 6 atm. Holding her breath, the marine biologist then ascends to a depth of 10 meters (where the pressure is now 2 atm). What volume would the air in her lungs expand to?
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text:
Billy Gardell
Jun 22, 2013 – 8:30 PM
Emerald Queen Casino
2024 E 29th Street
Tacoma, WA 98421 Map
Official Box OfficeFind Tickets ticketmaster
Secondary Box OfficeFind Tickets stubhub.com
More Info
Bring These Top Artists To Your City
Demand it! ®
and Never Miss a Show Again!
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text:
City to save $92,000 by refinancing
The Morris City Council on Tuesday approved a measure that could result in savings of about $92,000 by refinancing two bond issues and two loans.
The council approved authorizing Ehlers and Associates to solicit the sale of bonds at a lower interest rate that would be used to pay off debt on bond issues from 2003 and 2006 and two other loans.
The council is scheduled to meet Oct. 12 to consider proposals for the sale of new bonds. By combining the bonds and loans, the city also will save on administration fees by combining the four issues into one.
"Interest rates are low but they're probably not going too much lower so this is a good time to take advantage," said Brian Reilly, a financial advisor for Ehlers and Associates.
The total of the new issue would be about $2.76 million, and the terms of the bond issues does not change, said City Manager Blaine Hill.
In other city business:
The council approved using Capital Improvement reserves to order a new police car.
The car purchase was in the department's budget for 2011, but the cost will be about $2,000 lower if the city orders the car now instead of waiting until after Jan. 1, 2011.
Chief of Police Jim Beauregard said the city has a 1998 and 2003 squad cars that are either "dead in the water" or becoming to costly to continue repairing.
"If we can tap those resources now, it helps us tremendously," Beauregard said.
The new 2011 Chevrolet Impala will cost almost $21,000, with additional expenses for lighting. The department budgeted almost $24,000 in 2011 for a new squad. The new car will be ready in between 60 and 90 days.
Hill said using the fund now won't make a difference in the budget because the money would be used for a squad anyway, and that repeatedly fixing deteriorating cars can be expensive.
"If you don't keep up on them, you start seeing a lot of maintenance bills," Hill said.
The city's Truth in Taxation meeting is Dec. 14, at 6 p.m., at City Council chambers.
At the meeting, city officials present information about the 2011 budget and levy and the public is encouraged to speak or ask questions.
The City Council will visit the firehall to see improvements made thanks to FEMA grants obtained by the department. The council will visit the hall following its next meeting on Oct. 12.
City officials continue to work on the 2011 budget, and Hill said the city can expect to lose even more Local Government Aid when the Minnesota Legislature convenes early next year. At a recent forum of city officials, the consensus was that cities receiving LGA can look forward to a 10 percent to 15 percent reduction in aid. The City of Morris has lost about $500,000 in state aid since 2008, Hill has said. LGA accounts for about two-thirds of the city General Fund budget annually, which is approximately $3 million.


text:
Video: A$AP Rocky Interview w/ Google Play
Rocky sits down with Google Play and talks about the A$AP movement, technology, the films that influenced the "Wassup" video and more.
Previously: A$AP Rocky – DJ Semtex Freestyle
Rocky sits down with Google Play and talks about the A$AP movement, technology, the films that influenced the "Wassup" video and more.
Previously: A$AP Rocky – DJ Semtex Freestyle
he is the gayest dressed rapper ever…he beat out kanye for fuck boy fits
rex hussla Says:
January 24th, 2013 at 2:39 pm
Cool Macklemore track…nothing I have on my Ipod or anything…dude is headlining Paid Dues though, I don't get it either
Not bad
The introspective soulful shit white people be loving
Still better than anything b has done
I'm surprised in 2013 there has never been a gay nfl player in the NFL long storied history…thats actually suprising..
there is fuck boys in MLB, NBA, NHL, Tennis, Golf…but not in the NFL…NFL has remained masculine and hardbody
They say coaches and scouts subtly filter them out
I guess the NFL niggas don't want anything funnystyle in the pile
hugh hef Says:
January 24th, 2013 at 2:42 pm
he is the gayest dressed rapper ever…he beat out kanye for fuck boy fits
It's true
Kanye be picking at ASAP skirt like " Ooooooo girl ! Where'd you get that ?!?! "
Mac miller – all around the world (produced by just blaze)>>>>>>>>>>>>>>>
Says the guy who Stan's for Lil B
b you're too spiteful to make it in rap
You lol all the time and act like you just having fun with it
But you're not
You're just a poor petty man with no options
Hating will get you nowhere
It's crazy how kanye west is starting to dress worse and worse as he gets older
This faggot ass fanboy liegerian been arguin wit a masked fan for hours now and still ain't landed one blow. You my number one fan stayed cosign B da great.
The Based God ain't never wore no skirt nigga
Be clear.
B Says:
January 24th, 2013 at 2:40 pm
Damn Sam.
^who you got ya style from?!?
Been a fan
Keep quotin
> when u realize I didn't actually type any of the above ,it should be no doubt in y mind as to who the Mvc is ,most valuable commenter.niggas is arguing as if they actually are me. If nah was the rap game I would be like a jay z or Kanye,my buzz ain't never dying
SICK would have given you beats
But since he was too masculine to participate in your DP you got angry
You burning bridges b
That will get you no where
My two sons fighting again???
play nice or no dinner
So now you not that nigga
See what I mean
Chea vs chief Ali>>>>>>>>>>>>
Them niggas always posting subliminals
Lolol cp, u arguing with a mask.
Oh and after truth serum u shouldn't want to play this game.
Truth Serum>>>>>>>>>
Chief Ali just ran through with the double barrel sawed off aimed point blank at Chea's chest cavity, and bucked without even breaking stride.
Yeah A$AP definitely kissed a dude on the lips before … I tried to give him the benefit of the doubt but I dunno son.
Sometimes dudes be gettin so many bitches it fucks their head up.
Don't call me no pretty muthafucka, call me ugly. I prefer when chicks say "You're not my type" or try to call me ugly but want me to fuck.
I like being handsome …it's a different, dudes ain't suppose to be "fine" or "sexy" you're suppose to be HANDSOME male prowess that makes the pussy moist and magnetize to your dick as soon as you in the room or smile in their direction.
Them pretty dudes are sex objects and once they realize that they get insecure and start experimenting with penis…because they YEARN for someone to accept them as "MANLY and HANDSOME".
All them light skin boyish instagram and twitter cats with their shirt off cheesing in the pics with thousands of girls jocking are GAY.
Ole male dancers named Apollos or Sincere type muthafuckas.


text: June 10 (Reuters) - Most Southeast Asian stock markets closed higher on Wednesday on bargain hunting despite selling by foreign investors, but concerns over an early U.S. rate hike and uncertainty about Greece's debt talks limited gains. Indonesia's Jakarta Composite Index ended up 0.7 percent after hitting a more than 11-month low in the previous session and Singapore finished 0.9 percent higher, rebounding from the previous session's five-month closing low. Selling by foreign investors continued on Wednesday as well with Jakarta seeing net foreign fund outflow of $37.61 million, while it was $49.24 million for Malaysia and $20.19 million in the Philippines. Thailand saw net foreign selling of $35.46 million. U.S. job openings surged to a record high in April, suggesting the Federal Reserve would raise interest rates sooner than expected as the world's largest economy regained speed, while lingering Greek debt fears continued to add volatility to the market. A depreciation in Asian currencies has also weighed on risky assets, mainly in Indonesia, where the rupiah has fallen around 7.5 percent this year until Tuesday's close. The Thai share index closed 0.8 percent higher as Bank of Thailand (BoT) held benchmark interest rates steady after two surprise cuts. Thailand's large-caps recovered after MSCI's decision to delay the inclusion of China 'A' shares in one of its global benchmarks. Malaysia and Philippines rebounded from the previous session's five-month lows to close 0.4 percent and 0.8 percent higher, respectively. Bucking the regional trend, Vietnam's benchmark VN Index was down 0.1 percent, led by a fall in bank shares. For Asian Companies click; SOUTHEAST ASIAN STOCK MARKETS Change on day Market Current Prev Close Pct Move Singapore 3325.77 3295.13 +0.93 Kuala Lumpur 1735.63 1729.05 +0.38 Bangkok 1504.04 1492.32 +0.69 Jakarta 4933.56 4899.88 +0.69 Manila 7384.27 7323.44 +0.83 Ho Chi Minh 574.10 574.47 -0.06 Change on year Market Current End 2014 Pct Move Singapore 3325.77 3365.15 -1.17 Kuala Lumpur 1735.63 1761.25 -1.45 Bangkok 1504.04 1497.67 +0.43 Jakarta 4933.56 5226.95 -5.61 Manila 7384.27 7230.57 +2.13 Ho Chi Minh 574.10 545.63 +5.22 ($1 = 3.7325 ringgit) ($1 = 45.0400 Philippine pesos) ($1 = 13,310.0000 rupiah) ($1 = 33.6400 baht) (Reporting by Shihar Aneez in COLOMBO and Viparat Jantraprap in BANGKOK; Editing by Biju Dwarakanath)


text:
Separating Urban Agglomeration Economies in Consumption and Production
No abstract is available for this item.
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As the access to this document is restricted, you may want to look for a different version under "Related research" (further below) or search for a different version of it.
Volume (Year): 48 (2000)
Issue (Month): 1 (July)
Pages: 70-84
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References listed on IDEAS
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- Hansen, Lars Peter, 1982. "Large Sample Properties of Generalized Method of Moments Estimators," Econometrica, Econometric Society, vol. 50(4), pages 1029-1054, July.
- Power, Thomas M., 1981. "Urban size (dis)amenities revisited," Journal of Urban Economics, Elsevier, vol. 9(1), pages 85-89, January.
- Gyourko, Joseph & Tracy, Joseph, 1991. "The Structure of Local Public Finance and the Quality of Life," Journal of Political Economy, University of Chicago Press, vol. 99(4), pages 774-806, August.
- Roback, Jennifer, 1982. "Wages, Rents, and the Quality of Life," Journal of Political Economy, University of Chicago Press, vol. 90(6), pages 1257-1278, December.
- Fogarty, Michael S. & Garofalo, Gasper, 1980. "Urban size and the amenity structure of cities," Journal of Urban Economics, Elsevier, vol. 8(3), pages 350-361, November.
- Leo Sveikauskas, 1975. "The Productivity of Cities," The Quarterly Journal of Economics, Oxford University Press, vol. 89(3), pages 393-413.
- Blomquist, Glenn C & Berger, Mark C & Hoehn, John P, 1988. "New Estimates of Quality of Life in Urban Areas," American Economic Review, American Economic Association, vol. 78(1), pages 89-107, March.
- Kelley, Kevin C., 1977. "Urban disamenities and the measure of economic welfare," Journal of Urban Economics, Elsevier, vol. 4(4), pages 379-388, October.
- Kanemoto, Yoshitsugu & Ohkawara, Toru & Suzuki, Tsutomu, 1996. "Agglomeration Economies and a Test for Optimal City Sizes in Japan," Journal of the Japanese and International Economies, Elsevier, vol. 10(4), pages 379-398, December.
- Ethier, Wilfred J, 1982. "National and International Returns to Scale in the Modern Theory of International Trade," American Economic Review, American Economic Association, vol. 72(3), pages 389-405, June.
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text:
Folks, the benefit of your collective wisdom please. Our underfloor heating doesnt seem to playing ball at the moment. It heats the downstairs (obviously), but seems to be heating only our guest room and ensuite, at the far end of the house. Our lounge, kitchen and utility are not heating at all, the floor remains cold. Thermostats are set to 20C..it doesnt make any difference where we set them, nothing changes. The boiler is a Combi, with the settings for the heating at 6 (out of 9 settings) and again, it doesnt appear to matter where its set at, the above areas remain cold. Hot water is being produced without issue.
Ive had advice from a mate of a mate that underfloor needs leaving on permanently to work, which sounds like bollocks to me, is this correct? The thought of it blasting away from now until kingdom come fills my bank account with horror. As we are in and out at various times, we have it set to turn on and off at the usual times (0600 - 0900, 1100 - 1400, 1700 - 2230).
Anyone help us out, either professionals, or anyone with a similar problem resolved?


text:
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A fine pair of George III Old English Pattern Sauce Ladles made in London in 1793 by John Beldon.
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The Sauce Ladles have deep circular bowls and are modelled in the Old English Pattern. Both are well marked and the top of each stem is engraved with a contemporary Crest.
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Length: 7 inches, 17.5cm.
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text:
Garut Wins Oakley Indosections
The whole night, he looked so calm. Maybe he knew he had it locked up. Maybe he's just this cool all the time. Maybe it has to do with filed down teeth or something.
The judges agreed unanimously: Rizal Tanjung, Brad Gerlach, Tim Russo, Jason Childs and Mikala Jones.
The members voted him #1…across the board.
And, damn, it was just a sick section. Long barrels. A quiver of rodeo flips. Water shots. Cool theme. Creative music. How could he not win?
Congratulations to Garut Widiarta. When I handed over his cash prize, he immediately paid his editor (Nikko Solkkeil) and bought shots for the staff. Good form. This guy knows how to keep the team stoked.
The IndoSections premier was a rocking good time. Everyone showed up at Tipi Jabrik's massive surf-warehouse party station RAW and watched some of our favorite Innersection's: Mikala Jones, Mike Losness, Ozzy Wright and Peter Devries. Since they've all been completely re-made, this was probably their last night out. It's super fun to watch a string of Innersection's back to back on the big-screen…a glimpse of just how good the movie is gonna end up.
Then we showed all the local boys' sections and the screen and brought them up to help introduce their part. So much great surfing. Hard to believe this is a country of first generation surfers, cause the talent here is some of the best in the world.
It's literally painful for me to have to announce only five winners. A few of these sections were really deserving of the film — particularly Mega Semadhi and Made Raditya — but that's how it goes in a competition.
Logan was on the computer speed-editing a re-do of the whole film and 20-minutes later we watched a live first draft of Oakley Indosections. The order goes like this:
5. Betet Merta
4. Dede Suryana
3. Mustofa Jeksen
2. Lee Wilson
1. Garut Widiarta
The judges (you included) made just the right call. We've got just a week left to whip this little bonus feature into shape.
Meanwhile, Taylor is back in California finalizing the ALL NEW sections for the main event. OH MY GOD they are coming in so good. It's crazy, cause all these sections were winners to start with. Then to have guys go back with tight notes, and re-do everything…
Just wait. I've worked on a bunch of surf films these last couple years with Taylor and I've never been this excited. But the credit is not for me and Taylor, but the surfers and filmmakers pouring their love and art into this collaboration.
November 26th there will be premiers all around the country, mostly hosted by your local pro who made a section on the movie. Cool, huh. One global super-premier.
In the meantime, I'm still trying to recover from IndoSections and help finish this project….so we can start the next one.
Congratulations Garut. We always thought you shoulda qualified back when you entered Winter Round in February…so we're really stoked to this much more exciting and unique entry on the final DVD.
Stay tuned…the real reason we've been doing this is about to be revealed. We think you'll like it. A lot. —NM
[Big thanks to Oakley, who made this all possible, and RAW store who hosted a really fun evening. And all the judges and everyone who came out…THANK YOU. Humbling to be part of such a great surf community.]