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Genomes and Genes
thymidine phosphorylase
Summary: The enzyme catalyzing the transfer of 2-deoxy-D-ribose from thymidine to orthophosphate, thereby liberating thymidine. EC 126.96.36.199.
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Publications272 found, 100 shown here
- Thymidine phosphorylase mRNA stability and protein levels are increased through ERK-mediated cytoplasmic accumulation of hnRNP K in nasopharyngeal carcinoma cellsL C Chen
Chang Gung Molecular Medicine Research Center, Chang Gung University, Kwei Shan, Taoyuan, Taiwan
Oncogene 28:1904-15. 2009..nuclear ribonucleoprotein K (hnRNP K) is significantly correlated with the elevated expression of thymidine phosphorylase (TP), and high levels of both proteins are predictive of a poor prognosis in nasopharyngeal carcinoma (..
- Microvessel density, mast cell density and thymidine phosphorylase expression in oral squamous carcinomaGirolamo Ranieri
Clinical and Experimental Oncology Laboratory, National Cancer Institute, I 70126 Bari, Italy
Int J Oncol 21:1317-23. 2002..and progression of oral cancer, we investigated microvessel density (mVd), mast cell density (mCd) and thymidine phosphorylase (TP) expression in a series of 50 patients with T1-3 N0-1 M0 oral squamous carcinoma (OSC) and 21 ..
- A possible role of thymidine phosphorylase expression and 5-fluorouracil increased sensitivity in oropharyngeal cancer patientsG Ranieri
Department of Experimental Oncology, Unit of Interventional Radiology, Department of Critical Area and Surgery National Cancer Institute of Bari, Bari, Italy
J Cell Mol Med 11:362-8. 2007..We hypothesized a role for TP in oropharyngeal tumourigenesis and 5-FU activation in the adjuvant setting of OSC patients...
- The dual role of thymidine phosphorylase in cancer development and chemotherapyAnnelies Bronckaers
Rega Institute for Medical Research, KULeuven, Leuven, Belgium
Med Res Rev 29:903-53. 2009b>Thymidine phosphorylase (TP), also known as "platelet-derived endothelial cell growth factor" (PD-ECGF), is an enzyme, which is upregulated in a wide variety of solid tumors including breast and colorectal cancers...
- Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survivalA Giatromanolaki
Department of Pathology, Democritus University of Thrace, P O Box 128, Alexandroupolis 68100, Greece
Br J Cancer 85:881-90. 2001..Targeting the HIF pathway may prove of importance in the treatment of NSCLC...
- Immunohistochemical demonstration of fluoropyrimidine-metabolizing enzymes in various types of cancerShingo Kamoshida
Department of Pathology, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
Oncol Rep 14:1223-30. 2005..the drugs, such as dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyltransferase (OPRT), thymidine phosphorylase (TP), and thymidylate synthase (TS)...
- Blockage of 2-deoxy-D-ribose-induced angiogenesis with rapamycin counteracts a thymidine phosphorylase-based escape mechanism available for colon cancer under 5-fluorouracil therapyHendrik Seeliger
Department of Surgery, University of Regensburg, Regensburg, Germany
Clin Cancer Res 10:1843-52. 2004..weakness of conventional 5-fluorouracil (5-FU) therapy relates to expression of the intracellular enzyme, thymidine phosphorylase (TP)...
- Paracrine stimulation of endothelial cell motility and angiogenesis by platelet-derived deoxyribose-1-phosphateGiordano Pula
Department of Veterinary Basic Sciences, Royal Veterinary College, University of London, United Kingdom
Arterioscler Thromb Vasc Biol 30:2631-8. 2010..In this study, we assessed whether the release of dRP by platelets stimulates endothelial cell migration and angiogenesis...
- 2-Deoxy-D-ribose, a downstream mediator of thymidine phosphorylase, regulates tumor angiogenesis and progressionYuichi Nakajima
Department of Applied Physiology, Faculty of Medicine, University of Miyazaki, Kiyotake cho, Miyazaki, Japan
Anticancer Agents Med Chem 9:239-45. 2009..b>Thymidine phosphorylase (TP, EC 2. 4. 2...
- Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell culturesGiordano Pula
Cardiovascular Division, King s College London School of Medicine, King s College London, United Kingdom
Circ Res 104:32-40. 2009..This extensive proteomic analysis revealed the presence of the proangiogenic factor thymidine phosphorylase (TP)...
- 5-fluorouracil: mechanisms of action and clinical strategiesDaniel B Longley
Cancer Research Centre, Department of Oncology, Queen s University Belfast, University Floor, Belfast City Hospital, 97 Lisburn Road, Belfast BT9 7AB, Northern Ireland
Nat Rev Cancer 3:330-8. 2003..Such target genes might prove to be therapeutically valuable as new targets for chemotherapy, or as predictive biomarkers of response to 5-FU-based chemotherapy...
- Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancerRussell D Leek
Imperial Cancer Research Fund Tumor Pathology Unit, University of Oxford Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford OX3 9DU R D L, K L T, F P, H T, L C, K C G
Cancer Res 62:1326-9. 2002..of angiogenesis was also studied, and an inverse relationship was found between TAM HIF-2 alpha and tumor thymidine phosphorylase expression (P = 0.02)...
- Thymidine phosphorylase mutations cause instability of mitochondrial DNAMichio Hirano
Department of Neurology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, P and S 4 443, New York, NY 10032, USA
Gene 354:152-6. 2005..This disorder is caused by loss-of-function mutations in the gene encoding thymidine phosphorylase (TP) a cytosolic enzyme...
- Combined GADD45A and thymidine phosphorylase expression levels predict response and survival of neoadjuvant-treated gastric cancer patientsRudolf Napieralski
Department of Pathology, Technische Universitat Munchen, Munich, Germany
Clin Cancer Res 11:3025-31. 2005..We evaluated the expression of seven therapy-related genes to predict the clinical outcome of advanced gastric cancer patients treated with a neoadjuvant chemotherapeutic protocol...
- Up-regulation of extracellular signal-regulated kinase 1/2-dependent thymidylate synthase and thymidine phosphorylase contributes to cisplatin resistance in human non-small-cell lung cancer cellsJen Chung Ko
Department of Internal Medicine, Hsinchu Hospital, Chiayi, Taiwan
J Pharmacol Exp Ther 338:184-94. 2011..TS and thymidine phosphorylase (TP) are key enzymes of the pyrimidine salvage pathway...
- Heterogeneous ribonucleoprotein k and thymidine phosphorylase are independent prognostic and therapeutic markers for nasopharyngeal carcinomaLih Chyang Chen
Institute of Microbiology and Immunology, National Yang Ming University, Taipei, Taiwan
Clin Cancer Res 14:3807-13. 2008Heterogeneous ribonucleoprotein K (hnRNP K) regulates thymidine phosphorylase (TP) mRNA stability...
- Modulation of Rad51, ERCC1, and thymidine phosphorylase by emodin result in synergistic cytotoxic effect in combination with capecitabineJen Chung Ko
Department of Internal Medicine, Hsinchu Hospital, Department of Health, The Executive Yuan, Taiwan
Biochem Pharmacol 81:680-90. 2011b>Thymidine phosphorylase (TP) is the rate-limiting enzyme for the activation of capecitabine (pro-drug of fluorouracil), and as a useful predictor of tumor response to capecitabine-based chemotherapy...
- The role of thymidine phosphorylase, an angiogenic enzyme, in tumor progressionShin ichi Akiyama
Department of Molecular Oncology, Course of Advanced Therapeutics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 8544
Cancer Sci 95:851-7. 2004b>Thymidine phosphorylase (TP), an enzyme involved in pyrimidine metabolism, is identical with an angiogenic factor, platelet-derived endothelial cell growth factor (PD-ECGF)...
- Thymidine phosphorylase (platelet-derived endothelial-cell growth factor) in cancer biology and treatmentMasakazu Toi
Department of Clinical Trials and Research, Tokyo Metropolitan Cancer and Infectious Disease Centre, Komagome Hospital, Tokyo, Japan
Lancet Oncol 6:158-66. 2005b>Thymidine phosphorylase (TP) is often induced in the tumour microenvironment by physiological and chemical stress. Its induction protects cells from apoptosis and helps cell survival by stimulating nucleoside metabolism and angiogenesis...
- Hematopoietic gene therapy restores thymidine phosphorylase activity in a cell culture and a murine model of MNGIEJ Torres-Torronteras
Laboratori of Neuromuscular and Mitochondrial Disorders, Institut de Recerca Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
Gene Ther 18:795-806. 2011..MNGIE) is an autosomal recessive disorder caused by mutations in the TYMP gene, which encodes thymidine phosphorylase (TP)...
- Epstein-Barr virus latent membrane protein 1 induces the chemotherapeutic target, thymidine phosphorylase, via NF-kappaB and p38 MAPK pathwaysChia Chun Chen
Graduate Institute of Biomedical Sciences, Chang Gung University, 259, Wen Hwa 1st Road, Kwei Shan, Taoyuan 333, Taiwan
Cell Signal 22:1132-42. 2010High thymidine phosphorylase (TP) expression is significantly correlated with poor prognosis in patients with nasopharyngeal carcinoma (NPC)...
- Preoperative chemoradiation for rectal cancer using capecitabine and celecoxib correlated with posttreatment assessment of thymidylate synthase and thymidine phosphorylase expressionKeith R Unger
Department of Radiation Oncology, University of Virginia, Charlottesville, Virginia 22908, USA
Int J Radiat Oncol Biol Phys 80:1377-82. 2011Thymidylate synthase (TS) and thymidine phosphorylase (TP) expression have been shown to be predictors of response to therapy...
- Thymidine phosphorylase to dihydropyrimidine dehydrogenase ratio as a predictive factor of response to preoperative chemoradiation with capecitabine in patients with advanced rectal cancerC S Boskos
1st Radiation Oncology Department, Agios Savvas Anticancer Institute, Athens, Greece
J Surg Oncol 102:408-12. 2010To identify if thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD), and ratio TP/DPD levels in tumor tissues are potential predictive factors for response to combined preoperative chemoradiation with capecitabine, in ..
- Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in miceMisako Haraguchi
Department of Cancer Chemotherapy, Institute for Cancer Research, Third Department of Internal Medicin, Kagoshima University, 8 35 1 Sakura gaoka, Kagoshima 890 8520, Japan
Mol Cell Biol 22:5212-21. 2002b>Thymidine phosphorylase (TP) regulates intracellular and plasma thymidine levels...
- Vorinostat synergises with capecitabine through upregulation of thymidine phosphorylaseE Di Gennaro
Experimental Pharmacology Unit, Department of Research, Istituto Nazionale Tumori, National Cancer Institute Fondazione G, Via M Semmola, Pascale, Napoli 80131, Italy
Br J Cancer 103:1680-91. 2010..induce synergistic antitumour effects in combination with capecitabine by modulating the expression of thymidine phosphorylase (TP), a key enzyme in the conversion of capecitabine to 5-florouracil (5-FU), and thymidylate synthase (..
- Synergistic effect of curcumin and cisplatin via down-regulation of thymidine phosphorylase and excision repair cross-complementary 1 (ERCC1)Min Shao Tsai
Molecular Oncology Laboratory, Department of Biochemical Science and Technology, National Chiayi University, Chiayi, Taiwan
Mol Pharmacol 80:136-46. 2011..b>Thymidine phosphorylase (TP), an enzyme of the pyrimidine salvage pathway, is considered an attractive therapeutic target, and ..
- Differences and relationships of thymidine phosphorylase expression in tumor-associated macrophages and cancer cells in squamous cell carcinoma of the esophagusN Koide
Second Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan
Dis Esophagus 15:67-73. 2002b>Thymidine phosphorylase (TP), which has been shown to be identical to platelet-derived endothelial cell growth factor, is expressed in tumor-associated macrophages (TAMs) as well as cancer cells...
- Predictive and prognostic markers for the outcome of chemotherapy in advanced colorectal cancer, a retrospective analysis of the phase III randomised CAIRO studyMiriam Koopman
Department of Medical Oncology, Radboud University Nijmegen Medical Center, 6500HB Nijmegen, The Netherlands
Eur J Cancer 45:1999-2006. 2009..several biomarkers [dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyl transferase (OPRT), thymidine phosphorylase (TP), thymidylate synthase (TS) and excision cross-complementing gene (ERCC1)] for their prognostic and ..
- Thymidine phosphorylase/platelet-derived endothelial cell growth factor is upregulated in advanced solid types of gastric cancerT Yoshikawa
The Third Department of Surgery, Kanagawa Cancer Center, Yokohama City University, School of Medicine, Japan
Br J Cancer 79:1145-50. 1999Previous studies demonstrated that the immunohistochemical expression of thymidine phosphorylase (dThdPase) was related with distant metastasis and disease progression...
- Prognostic impact of thymidine phosphorylase expression in breast cancer--comparison of microarray and immunohistochemical dataE Ruckhäberle
Department of Obstetrics and Gynecology, Goethe University, Frankfurt M, Germany
Eur J Cancer 46:549-57. 2010Contrary findings exist according to the prognostic and predictive impact of thymidine phosphorylase (TP) expression in breast cancer...
- Suppression of thymidine phosphorylase-mediated angiogenesis and tumor growth by 2-deoxy-L-riboseHiroshi Uchimiya
Department of Cancer Chemotherapy, Institute for Cancer Research, Kagoshima University, Faculty of Medicine, Sakuragaoka 8 35 1, Kagoshima 890 8520, Japan
Cancer Res 62:2834-9. 2002b>Thymidine phosphorylase (TP), an enzyme involved in the reversible conversion of thymidine to thymine, is identical to an angiogenic factor, platelet-derived endothelial cell growth factor (PD-ECGF)...
- Inhibition of metastasis of tumor cells overexpressing thymidine phosphorylase by 2-deoxy-L-riboseYuichi Nakajima
Department of Molecular Oncology, Graduate School of Medical and Dental Science, Kagoshima University, Kagoshima Japan
Cancer Res 64:1794-801. 2004b>Thymidine phosphorylase (TP) catalyzes the reversible conversion of thymidine to thymine, thereby generating 2-deoxy-D-ribose-1-phosphate, which upon dephosphorylation forms 2-deoxy-D-ribose (D-dRib), a degradation product of thymidine...
- Site-specific somatic mitochondrial DNA point mutations in patients with thymidine phosphorylase deficiencyYutaka Nishigaki
Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Clin Invest 111:1913-21. 2003..MNGIE) is an autosomal recessive disorder caused by loss-of-function mutations in the gene encoding thymidine phosphorylase (TP)...
- Thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase expression, and histological tumour regression after 5-FU-based neo-adjuvant chemoradiotherapy in rectal cancerChristiane Jakob
Institute for Pathology, University of Technology, Fetscherstrasse 74, D 01307 Dresden, Germany
J Pathol 204:562-8. 2004..Response to pre-operative treatment, however, varies significantly. Thymidylate synthase (TS), thymidine phosphorylase (TP), and dihydropyrimidine dehydrogenase (DPD) are thought to be important predictors for the efficiency ..
- Different patterns of stromal and cancer cell thymidine phosphorylase reactivity in non-small-cell lung cancer: impact on tumour neoangiogenesis and survivalM I Koukourakis
Department of Radiotherapy Oncology and Saint Nikolas Histopathology Unit, University Hospital of Iraklion, Crete, Greece
Br J Cancer 77:1696-703. 1998..The P-GF.44C MAb was used to assess thymidine phosphorylase (TP) reactivity in cancer cells, stromal fibroblasts and macrophages...
- Identification of the angiogenic endothelial-cell growth factor-1/thymidine phosphorylase as a potential target for immunotherapy of cancerElisabeth H Slager
Department of Hematology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
Blood 107:4954-60. 2006..polymorphism (SNP) in the angiogenic endothelial-cell growth factor-1 (ECGF1) gene also known as thymidine phosphorylase. The SNP leads to an Arg-to-His substitution in an alternatively translated peptide that is recognized by ..
- Thymidine synthase, thymidine phosphorylase, and excision repair cross-complementation group 1 expression as predictive markers of capecitabine plus cisplatin chemotherapy as first-line treatment for patients with advanced oesophageal squamous cell carcinS Lee
Division of Hematology Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong Gangnam gu, Seoul 135 710, Korea
Br J Cancer 103:845-51. 2010Our purpose was to evaluate thymidine synthase (TS), thymidine phosphorylase (TP), and excision repair cross-complementation group 1 (ERCC1) expression as biomarkers for capecitabine and cisplatin (XP) combination chemotherapy in ..
- Cyclooxygenase-2 expression in endometrial cancer: correlation with microvessel count and expression of vascular endothelial growth factor and thymidine phosphorylaseRitsuto Fujiwaki
Department of Obstetrics and Gynecology, Shimane Medical University, Izumo, Japan
Hum Pathol 33:213-9. 2002..variables, microvessel count, and expression of vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP)...
- Thymidylate synthase, dihydropyrimidine dehydrogenase, ERCC1, and thymidine phosphorylase gene expression in primary and metastatic gastrointestinal adenocarcinoma tissue in patients treated on a phase I trial of oxaliplatin and capecitabineKazumi Uchida
University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198, USA
BMC Cancer 8:386. 2008..Over-expression of ERCC1 correlates with insensitivity to oxaliplatin (OX) therapy, while high thymidine phosphorylase (TP) levels predict for increased sensitivity to capecitabine (Xel).
- Thymidine phosphorylase expression and benefit from capecitabine in patients with advanced breast cancerC Andreetta
Department of Oncology, University Hospital of Udine, Udine, Italy
Ann Oncol 20:265-71. 2009..that is converted to 5-fluorouracil through several enzymatic steps, the last of which is mediated by thymidine phosphorylase (TP)...
- Neoadjuvant docetaxel and capecitabine and the use of thymidine phosphorylase as a predictive biomarker in breast cancerRachel M Layman
Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 0848, USA
Clin Cancer Res 13:4092-7. 2007b>Thymidine phosphorylase (TP) induction by docetaxel is a proposed mechanism for the observed preclinical synergy of docetaxel and capecitabine (DC)...
- Prognostic significance of thymidine phosphorylase and p53 co-expression in esophageal squamous cell carcinomaOota Makoto
Department of Academic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
Oncol Rep 9:23-8. 2002This study investigated the prognostic significance of thymidine phosphorylase (TP) and p53 expression in 96 surgically resected primary esophageal squamous cell carcinomas...
- Nucleophilic participation in the transition state for human thymidine phosphorylaseMatthew R Birck
Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue Bronx, New York 10461, USA
J Am Chem Soc 126:2447-53. 2004Recombinant human thymidine phosphorylase catalyzes the reaction of arsenate with thymidine to form thymine and 2-deoxyribose 1-arsenate, which rapidly decomposes to 2-deoxyribose and inorganic arsenate...
- Thymidine phosphorylase and dihydropyrimidine dehydrogenase levels in primary colorectal cancer show a relationship to clinical effects of 5'-deoxy-5-fluorouridine as adjuvant chemotherapyGenichi Nishimura
Department of Surgery II, School of Medicine, Kanazawa University, Kanazawa, Ishikawa 920 8641, Japan
Oncol Rep 9:479-82. 2002b>Thymidine phosphorylase (TP) converts 5'-deoxy-5-fluorouridine (5'-DFUR, doxifluridine), an intermediate metabolite of capecitabine, to 5-fluorouracil (5-FU)...
- p53, bcl-2 and thymidine phosphorylase as predictive markers of chemotherapy in patients with advanced and recurrent gastric cancerS Kikuyama
Department of Surgery, Tochigi National Hospital, Japan
Anticancer Res 21:2149-53. 2001To study the relationship between expression of p53, bcl-2, thymidine phosphorylase and Ki-67 and the response to chemotherapy and survival in patients with recurrent and advanced gastric cancer.
- Thymidine phosphorylase (platelet-derived endothelial cell growth factor) as a target for capecitabine: from biology to the bedsideGirolamo Ranieri
National Cancer Institute, Interventional Radiology Unit, Bari, Italy
Recent Pat Anticancer Drug Discov 1:171-83. 2006b>Thymidine phosphorylase (TP), also known as platelet derived endothelial cell growth factor (PD-ECGF), is an enzyme involved in thymidine synthesis and degradation and exerts an angiogenic activity, whereas N4 pentyloxy-carbonyl- 5'-..
- Molecular basis for the inhibition of hypoxia-induced apoptosis by 2-deoxy-D-riboseRyuji Ikeda
Department of Cancer Chemotherapy, Institute for Cancer Research, Kagoshima University, Sakuragaoka 8 35 1, Kagoshima 890 8520, Japan
Biochem Biophys Res Commun 291:806-12. 2002An angiogenic factor, platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP), stimulates the chemotaxis of endothelial cells and confers resistance to apoptosis induced by hypoxia...
- Elevated plasma deoxyuridine in patients with thymidine phosphorylase deficiencyRamon Marti
Department of Neurology, Columbia University College of Physicians and Surgeons, P and S 4 443, 630 West 168th Street, New York, NY 10032, USA
Biochem Biophys Res Commun 303:14-8. 2003Mutations in the nuclear gene encoding thymidine phosphorylase (TP) cause mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), an autosomal recessive disease with mitochondrial dysfunction and mitochondrial DNA abnormalities...
- Significance of monocyte chemotactic protein-1 and thymidine phosphorylase in angiogenesis of human cardiac myxomaTianshu Zhang
Second Department of Surgery, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
Circ J 67:54-60. 2003..of this study was to investigate whether the expression of monocyte chemotactic protein-1 (MCP-1) and of thymidine phosphorylase (TP) correlates with the angiogenesis and clinicopathologic features in cardiac myxoma...
- Prognostication of pancreatic adenocarcinoma by expression of thymidine phosphorylase/dihydropyrimidine dehydrogenase ratio and its correlation with survivalMuhammad Wasif Saif
Yale University School of Medicine, Yale Cancer Center, Section of Medical Oncology, 333 Cedar Street FMP 116, New Haven, CT 06520, USA
Expert Opin Drug Saf 8:507-14. 2009Dihydropyrimidine dehydrogenase (DPD) is the first rate limiting enzyme that catabolizes 5-fluorouracil. Thymidine phosphorylase (TP) catalyzes the last step that converts capecitabine into 5-fluorouracil...
- IFN gamma-induced up-regulation of PD-ECGF/TP enhances the cytotoxicity of 5-fluorouracil and 5'-deoxy-5-fluorouridine in bladder cancer cellsGang Li
Department of Urology and Reproductive Medicine, Graduate School, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyo ku, Tokyo 113 8519, Japan
Anticancer Res 22:2607-12. 2002..PD-ECGF/TP is an essential enzyme in converting 5'DFUR and 5FU to their active metabolites and can be up-regulated by some cytokines...
- Thymidylate synthase and thymidine phosphorylase gene expression as predictive parameters for the efficacy of 5-fluorouracil-based adjuvant chemotherapy for gastric cancerDong Hua
Oncology Institute of Wuxi, The Fourth Affiliated Hospital of Suzhou University, 200 Huihe Road, Wuxi 214062, Jiangsu Province, China
World J Gastroenterol 13:5030-4. 2007To investigate the prognostic role of thymidylate synthase (TS) and thymidine phosphorylase (TP) mRNA levels in T3 or T4 gastric cancer treated with 5-fluorouracil-based adjuvant chemotherapy.
- Inhibition of EGFR phosphorylation in a panel of human breast cancer cells correlates with synergistic interactions between gefitinib and 5'-DFUR, the bioactive metabolite of XelodaMaria Ait-Tihyaty
Cancer Drug Research Laboratory, Department of Medicine, McGill University Health Center Royal Victoria Hospital, 687 Pine Avenue West, Montreal, QC H3A 1A1, Canada
Breast Cancer Res Treat 133:217-26. 2012..The conversion of 5'-DFUR to the cytotoxic 5-FU, occurs primarily in the tumour and is catalyzed by thymidine phosphorylase (TP)...
- Modulation of vascular endothelial growth factor and thymidine phosphorylase in normal human endometrial stromal cellsMaysoon M Abbas
Department of Obstetrics and Gynaecology, Christchurch School of Medicine and Health Sciences and the New Zealand Centre for Reproductive Medicine, New Zealand
Fertil Steril 82:1048-53. 2004To study the regulation of vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP), two angiogenic factors, in cultured endometrial stromal cells...
- Induction of thymidine phosphorylase expression by AZT contributes to enhancement of 5'-DFUR cytotoxicityKengo Tsuneyoshi
Department of Molecular Oncology, Field of Oncology, Course of Advanced Therapeutics, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka 8 35 1, Kagoshima 890 8520, Japan
Cancer Lett 244:239-46. 2006b>Thymidine phosphorylase (TP) regulates intracellular thymidine metabolism and can enhance the anti-tumor effectiveness of 5'-deoxy-5-fluorouridine (5'-DFUR) by conversion of the pro-drug 5'-DFUR to 5-fluorouracil (5-FU) in tumor tissues...
- Heterogeneous ribonucleoprotein K and thymidine phosphorylase are independent prognostic and therapeutic markers for oral squamous cell carcinomaChi Sheng Wu
Molecular Medicine Research Center, Chang Gung University, Tao Yuan, Taiwan
Oral Oncol 48:516-22. 2012..In vitro experiments suggest that OSCC tumors with high levels of TP are more sensitive to 5'-DFUR treatment. Thus, cytoplasmic hnRNP K and TP may be potential prognostic and therapeutic markers for OSCC...
- Cyclooxygenase-2 in human malignant fibrous histiocytoma: correlations with intratumoral microvessel density, expression of vascular endothelial growth factor and thymidine phosphorylaseHideki Yamashita
Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Tottori University, 86 NIshi cho, Yonago, Tottori 683 8503, Japan
Int J Mol Med 14:565-70. 2004..tumors (BFHTs), comparing the expression of vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP), as well as intratumoral microvessel density (IMVD). COX-2 expression was noted in 22 (62...
- Prognostic value of thymidine phosphorylase activity in liver tissue adjacent to hepatocellular carcinomaTakahiro Ezaki
Department of Disaster and Emergency Medicine, Graduate School of Medical Science, Kyushu University, Fukuoka 812 8582, Japan
Int J Clin Oncol 10:171-6. 2005Measurement of thymidine phosphorylase (TP) activity in normal liver tissue adjacent to hepatocellular carcinoma (HCC) may predict multicentric recurrence a long time after an operation...
- Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopyYuen Li Chung
Department of Basic Medical Sciences, St George s Hospital Medical School, Cranmer Terrace, London, United Kingdom
Clin Cancer Res 10:3863-70. 2004Previous studies have shown that tumor response to capecitabine strongly correlates with tumor thymidine phosphorylase (TP). The aims of our study were to (a)...
- Prediction of the effect of capecitabine in gastric cancer by immunohistochemical staining of thymidine phosphorylase and dihydropyrimidine dehydrogenaseWasaburo Koizumi
Department of Gastroenterology, East Hospital, Kitasato University School of Medicine, Sagamihara City, Kanagawa, Japan
Anticancer Drugs 19:819-24. 2008The objective of this study was to investigate the relationship between the expression of thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) and the response to capecitabine in patients with advanced/recurrent gastric ..
- An optimal dosing schedule for a novel combination antimetabolite, TAS-102, based on its intracellular metabolism and its incorporation into DNATomohiro Emura
Cancer Research Laboratories, Hanno Research Center, Taiho Pharmaceutical Co, Ltd, Hanno City, Saitama 357 8527, Japan
Int J Mol Med 13:249-55. 2004TAS-102 is a combination drug consisting of alpha,alpha,alpha-trifluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI)...
- Correlation of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase with sensitivity of gastrointestinal cancer cells to 5-fluorouracil and 5-fluoro-2'-deoxyuridineTao Ma
Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
World J Gastroenterol 10:172-6. 2004..the expression levels of three metabolic enzymes of fluoropyrimidines: thymidylate synthase (TS), thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) in seven human gastrointestinal cancer cell lines, and to ..
- Thymidine phosphorylase gene transfer inhibits vascular smooth muscle cell proliferation by upregulating heme oxygenase-1 and p27KIP1Wei Li
Second Department of Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
Arterioscler Thromb Vasc Biol 25:1370-5. 2005b>Thymidine phosphorylase (TP) reportedly promotes endothelial cell migration and induces heme oxygenase (HO)-1 expression. However, its effect on vascular smooth muscle cells (VSMCs) is poorly understood...
- The Sp1 transcription factor is essential for the expression of gliostatin/thymidine phosphorylase in rheumatoid fibroblast-like synoviocytesKenji Ikuta
Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, MuzuhoMizuho ku, Nagoya, 467 8601, Japan
Arthritis Res Ther 14:R87. 2012Gliostatin/thymidine phosphorylase (GLS/TP) has angiogenic and arthritogenic activities, and aberrant GLS production has been observed in the active synovial membranes of rheumatoid arthritis (RA) patients...
- Localization of thymidine phosphorylase expression in colorectal carcinoma tissues by in situ RT-PCR assayKoshi Mimori
Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan
Oncology 62:327-32. 2002Abundant expression of thymidine phosphorylase (TP) mRNA and protein was observed in human carcinoma tissues relative to the corresponding normal tissues. However, the distribution of cells that express TP has not yet been determined...
- Expression of thymidine phosphorylase and VEGF in esophageal squamous cell carcinomaTakuma Nomiya
Department of Radiology, Tohoku University Hospital, 1 1, Seiryo machi, Sendai 980 8574, Japan
Oncol Rep 15:1497-501. 2006..717 for TP/VEGF[+/- or -/+] group, p=0.005). In conclusion, VEGF and TP expression seems to have a relationship with tumor angiogenesis, and co-expression of TP and VEGF seemed to be one of the unfavorable prognostic factors...
- Association of right-sided tumors with high thymidine phosphorylase gene expression levels and the response to oral uracil and tegafur/leucovorin chemotherapy among patients with colorectal cancerSotaro Sadahiro
Department of Surgery, Tokai University School of Medicine, Kanagawa 259 1193, Japan
Cancer Chemother Pharmacol 70:285-91. 2012....
- Importance of thymidine phosphorylase expression at the invasive front of T3 rectal cancer as a prognostic factorKazuhisa Yoshimoto
Department of Surgery, Jikei University School of Medicine, Tokyo, Japan
Dig Surg 23:331-5. 2006Vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP) are angiogenic factors...
- Importance of thymidine phosphorylase expression in tumor stroma as a prognostic factor in patients with advanced colorectal carcinomaMasamichi Yasuno
Department of Surgical Oncology, Tokyo Medical and Dental University, 1 5 45 Yushima Bunkyou ku, Tokyo 113 8519, Japan
Oncol Rep 13:405-12. 2005b>Thymidine phosphorylase (TP) is a unique enzyme involved not only in angiogenesis, but in 5-fluorouracil (5-FU) metabolism as well. TP is produced by both tumor and stromal cells...
- Role of tumor angiogenesis in gallbladder carcinoma: with special reference to thymidine phosphorylaseYukari Harino
Department of Surgery, Institute of Health Biosciences, University of Tokushima, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
Int J Clin Oncol 13:452-7. 2008Angiogenesis plays an important role in tumor growth and metastasis. Thymidine phosphorylase (TP), as well as vascular endothelial growth factor (VEGF), is known to be an angiogenic factor...
- Low thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase mRNA expression correlate with prolonged survival in resected non-small-cell lung cancerPeter P Grimminger
Department of General, Visceral and Tumor Surgery, University of Cologne, Germany
Clin Lung Cancer 11:328-34. 2010Thymidylate synthase (TS), thymidine phosphorylase (TP), and dihydropyrimidine dehydrogenase (DPD) are key enzymes in the 5-fluorouracil (5-FU) pathway...
- [Thymidine phosphorylase expressed in monocyte-macrophages enhanced anticancer effect of 5'-deoxy-5-fluorouridine on colorectal carcinoma cells]Ji min Zhang
Department of Gastrointestinal Surgery, The Second Hospital, Guangzhou Medicine School, Guangzhou 510260, China
Zhonghua Yi Xue Za Zhi 84:718-24. 2004To detect the thymidine phosphorylase (dThdPase) expression in colorectal carcinoma tissue, and clarify whether dThdPase expressed in macrophage-like cell lines, and monocytes from human peripheral blood can modulate the anticancer ..
- Expression of thymidine phosphorylase by macrophages in colorectal cancer tissuesJi min Zhang
Department of Gastrointestinal Surgery, the Second Hospital of Guangzhou Medical School, Guangzhou 510260, Guangdong Province, China
World J Gastroenterol 10:545-9. 2004To detect the thymidine phosphorylase (dThdPase) expression in human colorectal cancer tissues and cells.
- Localization of thymidine phosphorylase in advanced gastric and colorectal cancerMichiya Kobayashi
Department of Surgery, Kochi Medical School, Oko cho, Kohasu, Nankoku, 783 8505 Japan
J Mol Histol 35:69-74. 2004b>Thymidine phosphorylase (TP) is known to be more concentrated in human cancer tissues than in adjacent normal tissue based on findings using enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry...
- Thymidine phosphorylase expressed in macrophages enhances antitumor effect of 5'-deoxy-5-fluorouridine on human colorectal carcinoma cellsJimin Zhang
Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryomachi, Aoba ku, Sendai 980 8574, Japan
Anticancer Res 23:323-9. 2003b>Thymidine phosphorylase (dThdPase) is a key enzyme in the activation of the pro-drugs of 5-fluorouracil (5-FU), 5-deoxy-5-fluorouridine (5'-DFUR) and capecitabine...
- Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylasePhilip Reigan
School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK
Bioorg Med Chem Lett 14:5247-50. 2004A series of xanthine oxidase-activated prodrugs of known inhibitors of thymidine phosphorylase has been designed and synthesised to introduce tumour selectivity...
- Late-onset MNGIE due to partial loss of thymidine phosphorylase activityRamon Marti
Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Ann Neurol 58:649-52. 2005Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is caused by mutations in the gene encoding thymidine phosphorylase (TP)...
- The inhibitory effect of disease-modifying anti-rheumatic drugs and steroids on gliostatin/platelet-derived endothelial cell growth factor production in human fibroblast-like synoviocytesTakuma Kusabe
Department of Musculoskeletal Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, 467 8601, Japan
Rheumatol Int 25:625-30. 2005..These findings indicate that AuTG and DEX have anti-rheumatic activity, which is mediated via the suppression of GLS production. Neither methotrexate (MTX) nor sulfasalazine (SSZ) had a significant influence on GLS levels in our study...
- Carrier erythrocyte entrapped thymidine phosphorylase therapy for MNGIEN F Moran
Neurology, Kent and Canterbury Hospital, Ethelbert Road, Canterbury, CT1 3NG, UK
Neurology 71:686-8. 2008
- The thymidine phosphorylase inhibitor 5'-O-tritylinosine (KIN59) is an antiangiogenic multitarget fibroblast growth factor-2 antagonistSandra Liekens
Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium
Mol Cancer Ther 11:817-29. 20125'-O-Tritylinosine (KIN59) is an allosteric inhibitor of the angiogenic enzyme thymidine phosphorylase. Previous observations showed the capacity of KIN59 to abrogate thymidine phosphorylase-induced as well as developmental angiogenesis ..
- Mitochondrial neurogastrointestinal encephalomyopathy: novel pathogenic mutations in thymidine phosphorylase gene in two Italian brothersLaura Libernini
Division of Pediatric Neurology, Department of Pediatrics, Child Neurology and Psychiatry, La Sapienza University of Rome, Rome, Italy
Neuropediatrics 43:201-8. 2012..recessive multisystem disorder occurring due to mutations in a nuclear gene coding for the enzyme thymidine phosphorylase (TYMP)...
- Interferon gamma-dependent induction of thymidine phosphorylase/platelet-derived endothelial growth factor through gamma-activated sequence-like element in human macrophagesH Goto
Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Cancer Res 61:469-73. 2001b>Thymidine phosphorylase (TP), an enzyme involved in the reversible conversion of thymidine to thymine, is identical to platelet-derived endothelial cell growth factor...
- The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanismHarsh V Jain
Department of Chemistry, University at Buffalo, Buffalo, NY 14260, United States
Bioorg Med Chem Lett 20:1648-51. 2010The design and synthesis of 5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil (AIFU), a potent inhibitor of thymidine phosphorylase (TP) with K(i)-values of 11nM (ecTP) and 17nM (hTP), are described...
- Synthesis and in vitro evaluation of 5-fluoro-6-[(2-iminopyrrolidin-1-YL)methyl]uracil, TPI(F): an inhibitor of human thymidine phosphorylase (TP)John R Grierson
Department of Radiology, Division of Nuclear Medicine, University of Washington, Seattle, Washington, USA
Nucleosides Nucleotides Nucleic Acids 29:49-54. 2010..5-fluoro analog of TPI (5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]uracil), a potent inhibitor of human thymidine phosphorylase (TP), has an IC(50) in a range that might allow to use it labeled for imaging of TP expression in vivo...
- Angiogenic factorT Furukawa
Nature 356:668. 1992
- Platelet-derived endothelial cell growth factor/thymidine phosphorylase inhibitor augments radiotherapeutic efficacy in experimental colorectal cancerTomohiko Miyatani
Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto, Tokushima, Japan
Cancer Lett 318:199-205. 2012..However, there are few to be available in the clinical setting. Thymidine phosphorylase inhibitor (TPI) regulates the phosphorolysis of thymidine to thymine and 2-deoxy-d-ribose-1-phosphate ..
- Neurotrophic action of gliostatin on cortical neurons. Identity of gliostatin and platelet-derived endothelial cell growth factorK Asai
Department of Bioregulation Research, Nagoya City University Medical School, Japan
J Biol Chem 267:20311-6. 1992..These data indicate that gliostatin/PD-ECGF may play important roles on development and regeneration of the central nervous system and may also involve the induction of angiogenesis for the formation of blood brain barrier...
- The role of thymidine phosphorylase and thrombospondin-1 in angiogenesis and progression of intrahepatic cholangiocarcinomaShin ichi Aishima
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Int J Surg Pathol 10:47-56. 2002b>Thymidine phosphorylase (TP), an important regulator of angiogenesis, is correlated with progression, metastasis, and prognosis in various types of tumor...
- A case report of papilla Vater carcinoma showing positive expression of thymidine phosphorylaseShinji Osada
Second Department of Surgery, Gifu University School of Medicine, Gifu City, Japan
Hepatogastroenterology 51:375-7. 2004..The immunohistochemical stain showed the strong expression of thymidine phosphorylase in the tumor tissue and also in the normal biliary tract, despite positive p53 cells being undetected in ..
- The ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase in tumour tissues of patients with metastatic gastric cancer is predictive of the clinical response to 5'-deoxy-5-fluorouridineTomohiro Nishina
Department of Medical Oncology, National Shikoku Cancer Center, 13 Horinouchi, Matsuyama, Ehime 790 0007, Japan
Eur J Cancer 40:1566-71. 2004The aim of this work was to determine whether intratumour contents of thymidine phosphorylase (TP), which converts 5'-deoxy-5-fluorouridine (5'-DFUR) to 5-fluorouracil, and dihydropyrimidine dehydrogenase (DPD), which degrades 5-..
- Comparative analysis of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in colorectal cancer and surrounding normal tissueM Zimovjanova
Department of Oncology, General Teaching Hospital, 12880 Prague, Czech Republic
Neoplasma 52:208-10. 2005Thymidylate synthase [TS], thymidine phosphorylase [TP] and dihydropyrimidine dehydrogenase [DPD] play the essential role in the activation and catabolism of the fluoropyrimidines used in cancer therapy...
- Pd-ECGF positivity correlates with better survival, while iNOS has no predictive value for cervical carcinomas treated with radiotherapyKuniyuki Oka
Department of Pathology, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan
Int J Radiat Oncol Biol Phys 57:217-21. 2003Platelet-derived endothelial cell growth factor (PD-ECGF), which has angiogenic activity, is identical to thymidine phosphorylase. Tumor vascularization is considered to be an important prognostic factor...
- Neoangiogenesis in patients with gastric carcinoma in relation to the expression of vascular endothelial growth factor and thymidine phosphorylaseShunichi Tsujitani
Department of Surgery, Faculty of Medicine, Tottori University, Yonago, Japan
Anticancer Res 24:1853-9. 2004..the prognostic significance of microvessel density and the relationship between the expression of vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP), and angiogenesis in patients with gastric carcinoma.
- Thymidine phosphorylase in cancer cells stimulates human endothelial cell migration and invasion by the secretion of angiogenic factorsI V Bijnsdorp
Department of Medical Oncology, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
Br J Cancer 104:1185-92. 2011b>Thymidine phosphorylase (TP) is often overexpressed in tumours and has a role in tumour aggressiveness and angiogenesis...
- Association of tumour necrosis factor alpha and its receptors with thymidine phosphorylase expression in invasive breast carcinomaR D Leek
Imperial Cancer Research Fund Molecular Oncology Laboratory, University of Oxford, Institute of Molecular Medicine, John Radcliffe Hospital, UK
Br J Cancer 77:2246-51. 1998..The cytokine tumour necrosis factor alpha (TNF-alpha) and the enzyme thymidine phosphorylase (TP) are two factors known to promote tumour angiogenesis...
- FK506 inhibition of gliostatin/thymidine phosphorylase production induced by tumor necrosis factor-α in rheumatoid fibroblast-like synoviocytesTakaya Yamagami
Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, 467 8601, Japan
Rheumatol Int 31:903-9. 2011Gliostatin/thymidine phosphorylase (GLS/TP) is known to have angiogenic and arthritogenic activities. The purpose of this study was to determine the inhibitory effects of FK506 (tacrolimus) on GLS production in rheumatoid arthritis (RA)...
- Gliostatin/thymidine phosphorylase-regulated vascular endothelial growth-factor production in human fibroblast-like synoviocytesTomohiro Tanikawa
Department of Musculoskeletal Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho chou, Mizuho ku, Nagoya, 467 8601, Japan
Rheumatol Int 27:553-9. 2007Gliostatin/thymidine phosphorylase (GLS/TP) is known to have angiogenic and arthritogenic activities...
- Late-onset MNGIE without peripheral neuropathy due to incomplete loss of thymidine phosphorylase activityRoberto Massa
Department of Neurosciences, University of Rome Tor Vergata and IRCCS Fondazione S Lucia, Via Montpellier 1, I 00135 Rome, Italy
Neuromuscul Disord 19:837-40. 2009..Mutations in the TYMP/ECGF1 gene cause a loss of thymidine phosphorylase catalytic activity, disrupting the homeostasis of intramitochondrial nucleotide pool...
- Angiopoietin-1 is inversely related to thymidine phosphorylase expression in human breast cancer, indicating a role in vascular remodelingM J Currie
Anatomical Pathology, Canterbury Health, Christchurch Hospital, Christchurch, New Zealand
Clin Cancer Res 7:918-27. 2001..016) and a significant inverse correlation between Ang-1 and thymidine phosphorylase expression (P = 0.01)...
- Effects of platelet-derived endothelial cell growth factor/thymidine phosphorylase, substrate, and products in a three-dimensional model of angiogenesisD P Stevenson
Diagnostics Research Unit, Department of Obstetrics and Gynecology, King s College School of Medicine and Dentistry, London, United Kingdom
Am J Pathol 152:1641-6. 1998Platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) is associated with angiogenesis and the progression of human breast and ovarian cancers...
- Involvement of microsomal cytochrome P450 and cytosolic thymidine phosphorylase in 5-fluorouracil formation from tegafur in human liverT Komatsu
Faculty of Pharmaceutical Sciences, Kanazawa University, Japan
Clin Cancer Res 7:675-81. 2001..Because the conversion of tegafur into 5-FU has also been reported to be catalyzed by cytosolic thymidine phosphorylase (dThdPase), the involvement of human liver microsomes and cytosol and individual differences in 5-FU ..
Research Grants31
- Molecular Pathogenesis and Treatment of MNGIEMichio Hirano; Fiscal Year: 2013..MNGIE) is a fatal autosomal recessive disease caused by mutations in the TYMP gene encoding thymidine phosphorylase (TP)...
- Interactions of the angiopoietin and PD-ECGF pathways in tumor angiogenesisEdward L Schwartz; Fiscal Year: 2013..include a novel, highly specific, orally available small molecule inhibito of the angiogenic factor thymidine phosphorylase (TP) which we have synthesized, and two highly specific peptibodies which neutralize the angiogenic ..
- Mechanisms of thymide phosphorylase angiogenesisEdward L Schwartz; Fiscal Year: 2010..Sequencing of the of human PD-ECGF cDNA revealed it to be identical to human thymidine phosphorylase (TP), an enzyme which catalyzes the conversion of thymidine to thymine and 2-deoxyribose-1-phosphate (dR-..
- 3-D STRUCTURES OF URIDINE & THYMIDINE PHOSPHORYLASESSteven Ealick; Fiscal Year: 1991The objective is to determine the three-dimensional structures of uridine phosphorylase and thymidine phosphorylase. The pyrimidine phosphorylases may be responsible for the degradation of certain nucleoside analogs of potential ..
- TUMOR MARKERS TO PREDICT TREATMENT RESPONSELynn Dressler; Fiscal Year: 2005..We will evaluate whether specific markers of capecitabine metabolism, thymidylate synthetase, thymidine phosphorylase and dihyodropyrimidine dehydrogenase gene expression (mRNA) can predict recurrence and survival in ..
- ROLE AND FUNCTIONS OF PYRIMIDINES IN CANCER THERAPYGiuseppe Pizzorno; Fiscal Year: 2004..activity, and 3) why breast tumor tissues have a BAU-insensitive, phosphorolytic activity that is not thymidine phosphorylase. To achieve these objectives the research will center on two main projects in progress: isolation and ..
- ANTIANGIOGENESIS BY THYMIDINE PHOSPHORYLASE INHIBITORSGeorge Wright; Fiscal Year: 1999..One angiogenesis factor, platelet-derived endothelial cell growth factor (PD-ECGF), is identical with thymidine phosphorylase (TP), an enzyme of thymidine metabolism and homeostasis...
- CELLULAR INTERACTIONS OF 5 FLUOROURACIL AND INTERFERONEdward Schwartz; Fiscal Year: 2000..activity was identified: the induction of expression by IFN, both in vitro and in vivo, of the enzyme thymidine phosphorylase (TP)...
- MOLECULAR PROGNOSTIC INDICATORS IN COLORECTAL CANCERLeonard Saltz; Fiscal Year: 2000..Further data suggest that low expression of both thymidine phosphorylase and dihydropyrimidine dehydrogenase are consistent with responsiveness to FU/LV, while high expression of ..
- CLINICAL RESEARCH CENTER FOR NEUROMUSCULAR DISEASESalvatore DiMauro; Fiscal Year: 2007..of mitochondrial DNA deletions, depletion, and point mutations; (iii) studying the effects of thymidine phosphorylase (TP) deficiency in cultured fibroblasts; and (iv) studying the clinical and biochemical consequences of ..
- dUTPase As A Prognostic Marker in Colon CancerRobert Ladner; Fiscal Year: 2003..expression with other known prognostic markers of colorectal cancer including, thymidylate synthase (TS), thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD) and p53...
- Studies of the Pathogenic Mechanism of HIVMiles Cloyd; Fiscal Year: 2003..e., are activated and are undergoing "activation-induced cell death") or are thymidine phosphorylase+ (i.e...
- Mechanism of SHeA2 Action in Ovarian CancerDoris Benbrook; Fiscal Year: 2009..species, mitochondrial membrane depolarization, and inhibition of NF-kappaB activity and expression of thymidine phosphorylase and thrombospondin-4 gene expression...
- Biomodulation of capecitabine by docetaxel in non-small*MIGUEL VILLALONA; Fiscal Year: 2005..This synergy is believed due to upregulation of the enzyme thymidine phosphorylase (TP), which is responsible for the preferential tumor activation of capecitabine...
- PYRIMIDINE NUCLEOSIDE PHOSPHORYLASES IN CHEMOTHERAPYSHIH CHU; Fiscal Year: 1992..2. Biological testing of these new agents as inhibitors of uridine phosphorylase and, where indicated, thymidine phosphorylase, as transport inhibitors, anti-tumor agents and potentiators both in vitro and in vivo, and as tools for ..
- Phase l study of 131 I-HuA33 with oral capecitabine in*Andrew Scott; Fiscal Year: 2006..The final conversion to 5-FU is by thymidine phosphorylase, which is much more active in colorectal tumor tissue compared to normal tissues...
- MOLECULAR PROGNOSTIC INDICATORS IN ESOPHAGEAL CANCERPeter Danenberg; Fiscal Year: 2001..will investigate the association between intratumoral expressions of thymidylate synthase, ERCC1, thymidine phosphorylase, bcl-2, bax and the p53 mutational status in esophageal squamous cell carcinoma and adenocarcinoma ..
- ENZYME MARKER FOR HEMATOPOIETIC CELLSSohaib Khan; Fiscal Year: 1980b>Thymidine phosphorylase activity will be measured in leukemic cell lines of T- and B-cell origin. The enzyme activity will also be followed in human leukemias...
- Pathogenesis of a Novel Limb-Girdle Muscular DystrophyMichio Hirano; Fiscal Year: 2003..For the patients, achieving the proposed goals will allow more accurate prenatal diagnosis, genetic counseling, and perhaps contribute to more rational therapies in the future. ..
- Effect of ethanol on retinoid metabolism and signaling in zebrafish embryosWILLIAM BOSRON; Fiscal Year: 2007..We will assess the feasibility of performing targeted proteomics studies with tissues from other populations that express different SNPs in alcohol metabolizing enzymes. [unreadable] [unreadable] [unreadable]..
- The Role of Mitochondrial DNA Alterations in CancerLee Jun Wong; Fiscal Year: 2008..Results from this research project will help us understand the functional role of mitochondrial DNA alterations in cancer and identify potential novel targets for more effective therapeutic development. ..
- TRANSITION STATE ANALYSIS OF ENZYMATIC REACTIONSVern Schramm; Fiscal Year: 2007..unreadable]..
- Toxoplasma Adenosine Kinase & ChemotherapyMAHMOUD EL KOUNI; Fiscal Year: 2007..Determine the mechanism of selective toxicity of active compounds. These studies will utilize the complementary strengths of the investigators in a collaborative, integrated effort to achieve these goals. [unreadable] [unreadable]..
- Retinoid Metabolism in Hepatitic Stellate CellsWILLIAM BOSRON; Fiscal Year: 2005..Inhibitors of retinyl ester hydrolysis in stellate cells may be an effective therapeutic strategy for arresting stellate cell activation early in hepatic fibrosis. ..
- CALGB STUDIES OF BREAST CANCER IN THE ELDERLYRichard Schilsky; Fiscal Year: 2004..This well integrated project provides a multidisciplinary approach that will address many issues relevant to the treatment of elderly women with breast cancer. ..
- ERBB 2 ERBB 3 HETERODIMERIC RECEPTOR OF CARCINOMASYosef Yarden; Fiscal Year: 2004..This model will be examined by using mutant receptors, and the recycling machinery characterized in details. The suspected cancer-inhibitory activity of drugs interfering with ErbB routing will be tested in vivo. ..
- PERTUSSIS, DIPHTHERIA, CHOLERA TOXINS-INHIBITOR DESIGNVern Schramm; Fiscal Year: 2003..The goal of this work is to extend transition state inhibitor design to the complex reactions catalyzed by bacterial ADP-ribosylating toxins. ..
- CPT11 activation by carboxylesterases in colon cancerWILLIAM BOSRON; Fiscal Year: 2003..If there is a positive correlation, a future multi-institutional study will be proposed. ..
- Enhancement of 5-Fluorouracil Chemotherapeutic EfficacyMAHMOUD EL KOUNI; Fiscal Year: 2002..This will increase the use of FUra and enhance its commercial potential. Two patents have been awarded to protect the technology and were licensed to the Company. ..
- ADENOSINE KINASE TARGET FOR CHEMOTHERAPY IN TGONDIIMAHMOUD EL KOUNI; Fiscal Year: 2001..gondii; (3) evaluate active compounds as potential antitoxoplasmosis agents in vitro and in vivo. ..


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In November, voters will decide whether the Richmond County Board of Education should have the authority to approve or deny attempts by organizations to open charter schools in the district.
It comes to the voters after the Georgia General Assembly passed a constitutional amendment in March allowing the state to create charter schools that function with local funding, even if local boards object.
Opponents of the bill are now working to make sure the public understands the ballot issue. Local educators and legislators are holding a rally Saturday to give information about the legislation, H.R. 1162.
Those holding and speaking at the rally are opposed to the bill, as is the RCBOE, which passed a resolution earlier this year condemning it.
RCBOE member Barbara Pulliam, a sponsor of Saturday's rally along with Richmond County Council of PTAs President Monique Braswell and Sandridge Community Association President Sammie Sias, said she fears state charter schools will funnel students out of the school system, which will have a corresponding financial impact on the district.
"We are already hurting financially," Pulliam said. "It can't do anything but devastate the school system with more money being pulled out of it and given to a state charter."
Georgia Federation of Teachers President Verdaillia Turner, who will speak at the rally with state Rep. Gloria Frazier, said finances and accountability are the biggest problems with letting charter schools start up.
She said charter schools take authority away from local districts while also taking money and children.
"There's only one money pot, and the money coming from the state is already being shortchanged to local districts," Turner said. "Now it's going to be shortchanged even more."
Proponents of the legislation say it would secure the state's partnership in public education and facilitate the process for opening charter schools.


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intrinsic motivation to learn involves engaging in learning opportunities because they are seen as enjoyable, interesting, or relevant to meeting one's core psychological needs (13). As a result, intrinsic motivation is associated with high levels of effort and task performance (11). Students with greater levels of intrinsic motivation demonstrate strong conceptual learning, improved memory, and high overall achievement in school (7). These students are more likely to experience a state of deep task immersion and peak performance (14, 15). Studies have also shown that students with higher intrinsic motivation are also more persistent (9, 17). In fact, intrinsic motivation is a powerful factor in performance, persistence to learn, and productivity (8).
Because intrinsic motivation has such a positive impact on school performance, we administered the Intrinsic Motivation Inventory (IMI), a survey that assesses levels of intrinsic motivation, following our traditional course in renal physiology taken by second-year medical students. Accordingly, we asked two pertinent questions: 1) What percentage of our class has low intrinsic motivation? and 2) Do students with low intrinsic motivation have lower academic performance?
All procedures were reviewed and approved by the Institutional Review Board of Edward Via College of Osteopathic Medicine, and informed consent was obtained from all students. The class was comprised of 159 medical students (89 females and 70 males). Class sessions were lecture-based with the use of instructor-generated PowerPoint slides. Students were also encouraged to supplement lecture content by reading the recommended textbook. All sessions were taught by the same instructor, who has had more than 5 yr of experience teaching renal physiology to medical students.
The IMI is a multidimensional device that assesses students' motivation for a particular task. The tool assesses students' interest and enjoyment, perceived competence, perceived choice, and relatedness while performing a specific activity. The interest and enjoyment subscale is considered the self-reported measure of intrinsic motivation. The perceived choice, perceived competence, and relatedness subscales are theorized to be positive predictors of both self-reported and behavioral measures of intrinsic motivation. There is strong support for use of this assessment tool to evaluate an individual's intrinsic motivation in terms of both the validity (10) and reliability (16). Additional information as well as access to the IMI can be obtained online at http://www.selfdeterminationtheory.org/questionnaires/10-questionnaires/50.
The IMI was made available online at the end of the course over a 7-day period. To encourage students' voluntary participation, three e-mail reminders were sent during the time period that the survey was available. Of 159 students, 133 completed the survey (76 females and 57 males) for a survey response rate of 84%.
To determine how many students had low intrinsic motivation, all survey scores for the interest and enjoyment subscale were averaged, and the standard deviation (SD) was calculated. Subsequently, low intrinsic motivation was operationally defined as scores 1 SD or more below the mean. Accordingly, the low intrinsic motivation (LIM) group comprised students who scored 1 SD or more below the mean on the interest and enjoyment subscale. All students with scores above this value comprised the high intrinsic motivation (HIM) group. The students within each group remained consistent for calculating the mean values for the remaining parameters (i.e., perceived competence, perceived choice, relatedness, and course grade). Descriptive statistics and means ± SE are reported. An unpaired Student t-test was used to determine mean differences between the HIM group and the LIM group. Statistical significance for group mean comparisons was set a priori at P < 0.05.
Figure 1 presents the interest and enjoyment, perceived competence, perceived choice, and relatedness subscales of the IMI for the HIM and LIM students. A total of 29 students (21.8% of the class) had low intrinsic motivation, which was defined as being 1 SD or more below the mean interest and enjoyment survey value.
The perceived competence, perceived choice, and relatedness subscales are theorized to be positive predictors of intrinsic motivation. All subscales were significantly lower in the low intrinsic motivation group (Fig. 1).
Importantly, low intrinsic motivation was also associated with lower class performance. Specifically, course grades were lower for the LIM group compared with those with HIM (Fig. 2).
Thus, results document that 21.8% of our class scored low on the interest and enjoyment subscale of the IMI documenting low intrinsic motivation. These same students also scored low on the perceived competence, perceived choice, and relatedness subscales of the IMI (Fig. 1). Importantly, the students with low intrinsic motivation also had lower class performance (Fig. 2).
It is important that students develop an interest and enjoyment for learning. In this context, inspiring and motivating students is critical. Once students are inspired and motivated, there are countless resources available to learn more about a subject. (4) As examples, a recent study from our group with undergraduate students (1) as well as others demonstrated that the level of intrinsic motivation has the most positive impact on school performance (3, 5, 6, 12, 17, 18). Accordingly, educators are profoundly interested in how to motivate individuals they educate to mobilize their efforts and persist at tasks inside and outside the classroom. Although students are often moved by external rewards such as grades or evaluations, students are motivated mainly from within by interests and curiosity. These intrinsic motivations can sustain passions, creativity, and efforts toward learning.
Education influences every aspect of life. In fact, human survival and our quality of life depend on educated citizens capable of making informed decisions regarding the challenges of the 21st century (2). Our most valuable resources in addressing the challenges of the 21st century are our students, each of whom is indispensable as we search for solutions to these challenges; no talent should be wasted. To avoid the loss of talent, procedures for early identification of students who may have low intrinsic motivation should be established. Although this is a challenging problem, solving it has powerful implications for students, the school they attend, and society as a whole. Accordingly, we are advocating a longitudinal experiment in which intrinsic motivation is assessed at the outset and periodically during a curriculum that fosters a cooperative learning community.
No conflicts of interest, financial or otherwise, are declared by the authors.
R.A.A., H.L.L., R.N.C., and S.E.D. conception and design of research; R.A.A. performed experiments; R.A.A., P.G., and S.E.D. analyzed data; R.A.A., A.Z.A., P.G., H.L.L., R.N.C., and S.E.D. interpreted results of experiments; R.A.A. and S.E.D. prepared figures; R.A.A. and S.E.D. drafted manuscript; R.A.A., A.Z.A., P.G., H.L.L., R.N.C., and S.E.D. edited and revised manuscript; R.A.A., A.Z.A., P.G., H.L.L., R.N.C., and S.E.D. approved final version of manuscript.
- Copyright © 2016 The American Physiological Society


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The Havoc Haus & Psy-Fi Present:
The Double Dip feat. DrFameus (Allen of the Disco Biscuits)
The Blockley
3801 Chestnut St
Philadelphia, PA, 19104
Doors 8:00 PM / Show 9:00 PM (event ends at 2:00 AM)
This event is 21 and over
Sounduo is a post-dub, audio/visual live performance project. It features poly-rhythmic hip-hop grooves, vintage samples, soulful vocals, ambient soundscapes, and heavy synth bass passed through a scuzzed-out dub filter and mangled using the latest in glitch technology, live. Masters of creating a futuristic glowing dub atmosphere while maintaining the bass-driven, party-vibe feel of bass music, Sounduo has showcased their abilities to cater to both festival environments as well as intimate club settings. Whether performing in the Southeast at some of the biggest music festivals (Ultra,Blackwater,Aura, Winter Music Conference, Art Basel), sharing dates with artists such as Big Gigantic, Elliot Lipp, Zoogma, and Archnemesis, headlining club dates, or being featured on prominent electronic blogs, Sounduo's buzz for their live performances has steadily grown and the next year promises to be a leap forward for these electronic and visual dub pioneers.
With the release of 'Departures,' their debut LP on Made in Glitch (Bass Science, Gladkill, NastyNasty,Samples,GRiZ), and subsequent Southeast regional tour in early 2012, Sounduo continues to push the boundaries of post-dub/glitch music and are poised to enter the national arena. Stay tuned for more releases as well as dates, videos, and updates from Sounduo.
Sounduo strives to bring a positive energy through music. Check out free music at sounduo.bandcamp.com, on youtube, or soundcloud.com/sounduo, and stay up to date @ facebook.com/sounduo. Thanks!
Band Interests
Positivity, heavy bass parties, conscious music, steady livity, soundsystem throw-downs, tape delay and phasers on maximum flange, samplers, visuals.
$7.00 - $10.00
Who's Going
Upcoming Events
The Blockley
- Sorry, there are currently no upcoming events.


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WASHINGTON, DC – The House Energy and Commerce Health Subcommittee, chaired by Rep. Joe Pitts (R-PA), today convened a hearing with Health and Human Services Secretary Kathleen Sebelius to discuss the president's fiscal year 2012 budget requests and implementation of the health care law. This was Secretary Sebelius' first time testifying before the subcommittee since the passage of the health care package.
"With the enactment of the Patient Protection and Affordable Care Act (PPACA), we have found there are several sections of this new law that require mandatory funding – hence, bypassing the normal appropriations process," said Pitts. "Today's hearing was critical to provide members the opportunity to examine these provisions and consider the budgetary implications for implementation and administration of this new law."
During the hearing, Rep. John Shimkus (R-IL) questioned whether the law's $500 billion in Medicare cuts were being used to sustain Medicare or fund the health care law. Secretary Sebelius responded, "Both."
Click to watch video HERE.
"I was shocked to hear the Secretary admit that $500 billion is double counted in the health care law," said Shimkus. "We knew the health care law's actual cost was much greater than originally told to the public. And now, the truth is slowly coming out in administration reports and testimony."
Pitts said, "As Rep. John Shimkus pointed out, to pay for Obamacare's new entitlements, more than $500 billion is taken out of Medicare. Meanwhile, the administration claims that these reductions are sustaining Medicare. The same dollar can't be used twice. This is the largest of the many budget gimmicks Democrats used to claim Obamacare would reduce the deficit."
After a witness from the Centers of Medicare and Medicaid Services yesterday failed to provide the subcommittee with an estimate on the amount of Medicare/Medicaid fraud, Rep. Marsha Blackburn (R-TN) pushed Secretary Sebelius to provide an estimate. The secretary also replied, "We don't know."
Click to watch video HERE.
"It is distressing that HHS can't quantify the amount of fraud in Medicare and Medicaid. Rather than stop the fraud, the administration pours more money into the system; overwhelming it and creating a bigger target for those who would defraud the taxpayer. This is another example of an administration plan that sounds good until you press for details and discover there aren't any," Blackburn responded.
Members of the subcommittee also expressed concern regarding HHS' unprecedented power authorized in the health care law.
Click to watch video HERE.
"There is unprecedented power that goes to your office and unprecedented spending that goes to your office. These are decisions that are made exclusively by the Secretary of Health and Human Services. At no other time in our history has so much power gone to one federal agency," said Rep. Michael Burgess (R-TX).
Chairman Pitts concluded, "The hearing left us with many more concerns than could be addressed during the limited time the secretary had to appear. Her department has handed out over 900 waivers to the law just to keep the current insurance system from collapsing. States are staring down billions of dollars in new Medicaid costs at a time of already tight budgets. The list of concerns with Obamacare is long and growing."


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White House releases Obama birth certificate
Now the big question is how many Americans will reject the official birth record proving that Barack Obama was born in the United States and still insist on believing — despite every fact in evidence — that he was born in a foreign land and thus not eligible under the Constitution to be president?
Some fringe of the nation's population almost surely will never be convinced, analysts said, but Obama evidently felt enough pressure to try to take the issue off the table after letting it fester for more than two years.
On Wednesday the president released the long-form version of his Hawaii birth certificate. His lawyer formally requested two certified copies on April 22 and picked them up Tuesday.
"Yes, in fact, I was born in Hawaii, August 4, 1961, in Kapiolani Hospital," Obama said in the White House briefing room, looking somewhat incredulous to be making such a statement. Hawaiian officials, a short-form official birth certificate, local newspaper reports of his birth and fact-checking expeditions by news media long ago had confirmed his Hawaiian birth, but some conservative politicians and media commentators refused to accept it.
"Normally, I would not comment on something like this," Obama said, but he said he felt compelled to try to put the issue to rest after questions about his birth certificate drowned out news coverage of the deficit crisis.
"We do not have time for this kind of silliness," the president said. "We're not going to be able to solve our problems if we get distracted by sideshows and carnival barkers."
It was a weird controversy to dog a president who is mired in military conflicts in three Muslim lands as the Arab world writhes in turmoil and the U.S. economy remains shaky, but it wouldn't go away. A USA Today poll released this week found that just 38 percent of Americans believed that Obama definitely was born in the United States.
Analysts disagreed over the episode's political significance.
Aides to the president denied that Obama feared that the controversy could hurt his re-election bid. Dan Pfeiffer, the White House communications director, said it was "probably in his long-term political interests to allow this 'birther' debate to dominate discussion in the Republican Party for months to come. But he thought, even though it might have been good politics, he thought it was bad for the country."
However Dan Schnur, a former Republican consultant who now directs the University of Southern California's Unruh Institute of Politics, said that explanation seemed hollow: "As long as it made Obama's critics look like extremists, they were happy to let the issue rage. Whether it's driven by Donald Trump or mainstream media coverage or a combination of both, the number of Americans who are uncertain about his birth status has been growing. The White House would never have taken this step if they didn't think it was hurting the president politically."
By putting the new documentation out there, Schnur said, "in the long run it gets a growing problem out of the way."
Maybe. Perhaps Obama gained credibility with some. But then again, maybe he just spun the story's news cycle another round.
Julian Zelizer, a Princeton University historian, said Obama's aides might think that "for at least a moderate voter it will reiterate the argument that some people in the Republican Party are real extremists" and "here's the president being the responsible figure and revealing what the opposition is all about."
But Zelizer isn't convinced that the president's move was wise.
"The smart thing would have been to continue to ignore it, or deal with it back during the campaign," he said. "Doing it now was a bit odd. The supporters of Obama will say, 'Why are you caving in to this kind of debate?' and the opportunists will probably just use it somehow to say is he up to something.
"In the end, the birthers will continue to raise questions about this document."
Did all the squawking over the president's place of birth overwhelm public debate on serious subjects? That's a matter of interpretation.
A weekly news analysis by the Pew Research Center's Project for Excellence in Journalism found that coverage of Obama's birthplace composed less than 3 percent of the news the week of April 18-24.
However, Trump, the TV-celebrity businessman who is relishing tons of free news coverage for sounding off about politics, was the second leading newsmaker last week, behind only the president. And Trump focused a lot on questioning Obama's birthplace. Deficit-related coverage, meanwhile, sank last week to only 8 percent of news.
Whatever the president's reason for finally issuing his birth certificate, it provided an extraordinary morning of political theater. During the 2008 campaign, Obama released a short-form certificate of live birth, which Hawaii treats as the legal version of a birth certificate. State officials confirmed the document's legitimacy.
Getting the state to release the long-form version was more complicated. The president and his lawyers had to write to the state to seek a waiver to release it. Obama's personal attorney Judith Corley flew to Hawaii to bring back two certified copies herself, returning Tuesday evening.
One copy was on display Wednesday in White House press secretary Jay Carney's office, while the other remained in the custody of White House Counsel Bob Bauer.
Trump, speaking before TV cameras in New Hampshire, said he was "really proud" to have forced the president to produce the information, and that Obama should have done so "a long time ago." Trump also said "I'd want to look at it" before accepting the document's legitimacy, but added that he hopes to move on to more important issues.
Schnur said the birth certificate "actually may remove a potential headache for the more establishment Republican candidates. They don't have to worry about whether or not to appease the skeptics on this anymore. This puts the birthers back in the category of the truthers. Someone who still believes Barack Obama was not born in Hawaii becomes the equivalent of someone who believes George Bush ordered planes to be flown into the World Trade Center."


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Ladies, settle down! We're still unsure whether Arab Idol contestant Salma Rashid is romantically-involved with Idol winner Mohammad Assaf [2]; but rumor has it that the two are getting engaged after Ramadan.
In a radio interview in Morocco, the singer was told by the show's host that a reliable source had confirmed the news to him.
But Salma was adamant that this is nothing but another rumor. Hmm, we smell something fishy!
Fans weren't convinced either after watching the YouTube clip of her suspenseful interview. Her facial expressions weren't oh-so-innocent [3], which raised a few eyebrows.
Liar liar, pants on fire!
Assaf's family denied the news as well, saying that when their son weds, it will be to a Palestinian girl from their hometown Gaza [4]. Patriots.com!
The jury's out! Guess we'll just have to wait until the end of Ramadan. Tick Tock, Tick Tock!
Do you guys think Assaf and Salma would make a cute couple?
[1] http://www.syndigate.info
[2] http://www.albawaba.com/entertainment/three-times-charming-assaf-free-concerts-palestine-503862
[3] http://www.albawaba.com/entertainment/cat-fight-arab-idols-yousra-salma-thrash-it-out-over-assaf-503203
[4] http://www.albawaba.com/entertainment/welcome-home-honey-mohammad-assaf-makes-triumphal-return-gaza-502306
[5] http://www.albawaba.com


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George: Why this year should be better for the Dallas Cowboys offensive line
Cowboys beat writer Brandon George answered questions in a chat on Friday. Here are some highlights.
I feel that if you're more athletically gifted as an OL it's easier switching schemes, whereas someone like Doug Free has to master the technique and scheme in order to hold his own. Do you think Free will do better as he learns the scheme better?
Yes, no doubt. But it was more about the difference in teaching styles with Houck and Callahan, especially in regard to footwork. It took the Cowboys more time to adjust and you have to remember that the starting OL didn't play as a whole together basically until the start of the regular season because of injuries. Last off-season, the Cowboys were learning Callahan's style and what he wanted them to do. This year, they know that and it's more about improving and moving forward ... That should help in year two.
Does Leary have a real chance at starting?
I don't think he'll start. At least not right away. He could move into a starting spot if either of the other two guards struggle and Leary takes a big step forward in his second NFL season. Jerry Jones is really high on Leary, so there's that.
Both Jerry and his son maintain that they are not disappointed with the performance of Felix Jones. What is with that?
Well, you have to remember that Felix is from Arkansas and there's that connection. But the Cowboys can say all they want, the bottom line is that Felix was a first-round draft choice in 2008 and for him not to develop into an NFL starter at any point means that he was a bust. First-round draft choices should be used on starters.


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MEMPHIS, Tenn. -- The Memphis Tigers found some benefit from playing Division II LeMoyne-Owen in midseason: a win to end their two-game home skid.
Nick King scored 18 points and No. 17 Memphis defeated the Magicians 101-78 on Saturday, a needed relief for the Tigers (13-4) who had dropped consecutive home games to Cincinnati and Connecticut before the victory.
Meanwhile, LeMoyne-Owen (4-10), a member of the Southern Intercollegiate Athletic Conference, lost its third straight and fifth in the last six.
''It is just a game to bounce back,'' King said. ''[The UConn] loss was a tough loss for the whole team. We just needed this to get our minds back on track.
''At the UConn game, it was a mental thing. This game, we were more locked in because we were in desperation mode. We knew we had to win the game.''
Austin Nichols and Geron Johnson finished with 12 points each for Memphis, Nichols hitting all six of his shots. Johnson also had nine rebounds and seven assists. Kuran Iverson scored 11 points, and Shaq Goodwin added 10 for Memphis.
Demba Konate led the Magicians with 17 points, while Daequan Mitchell-Fields finished with 16 points. Marcel Hawkins had 11 and Jerry Hampton scored 10.
Memphis coach Josh Pastner promised to play LeMoyne-Owen to benefit the small school located in South Memphis and had to schedule the game in January to keep his word.
''I was proud of the way we bounced back after the loss to Connecticut,'' Pastner said.
LeMoyne-Owen coach William Anderson also recognized the benefit of the game to the Tigers.
''I think Memphis needed an easy win coming off that hard game against Connecticut,'' Anderson said. ''They were able to get some guys some playing time that haven't got some playing time, so I think it was a win-win for both institutions.''
Memphis started a bit lackadaisical, trying to muster any enthusiasm for the game after the start of its first season in the American Athletic Conference.
LeMoyne-Owen was within 15-14 with 13 minutes left in the first half when Memphis started taking control, eventually carrying a 52-33 lead into halftime.
''They played us pretty tough in the first half,'' Nichols said.
The Tigers managed to shoot 60 percent for the half. King, a reserve, already had 13 points, including shooting 4 of 5 from the field.
Pastner substituted freely in the half, at times making a complete, five-player change. It was a substitution pattern he would follow through much of the game.
No Magicians player was in double figures at the half, but reserve Naffe Toure already had fouled out, playing 8 minutes and missing his only shot. Starter Victor Shell already was saddled with four fouls in the first half and fouled out in the second.
Memphis continued to build the lead after the break as the Tigers converted better than 50 percent of its shots. The Tigers would end the game shooting 59 percent, compared to 40 percent for the Magicians.
Pastner also noted that the Tigers had 29 assists on 38 made field goals.
While the Magicians didn't put up much resistance, Pastner said every win is important, particularly as they try to work their way through conference play.
''It was a good win, and it counts on our official record,'' he said.


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Nebraska Revised Statute 59-1754
- Revised Statutes
- Chapter 59
- 59-1754
Seller; failure to deliver products; contract voidable.
If a seller fails to deliver the equipment, supplies, or products within thirty days of the delivery date stated in the contract, unless such delivery delay is beyond the control of the seller, then at any time prior to delivery or within thirty days after delivery, at the election of the purchaser upon written notice to the seller, the contract shall be voidable by the purchaser and unenforceable by the seller or his or her assignee.
- Laws 1979, LB 180, § 54.


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This event has been marked mature level 1 due to the following, "dick".
Doors Open at 6:00pm/ Show Starts at 7:00pm
Duke Michaels
Duke's love for the guitar was inspired by his mother and her family's love of music. Duke's study of music began in Globe Miami Arizona where he played with Catholic nuns in a 1st and 2nd grade guitar group. He studied Flamenco, Spanish, and Classical guitar styles in Palo Alto California with Richard Jaqua. He continued his studies with various teachers through several states and began teaching himself how to write and sing rock 'n' roll. Duke's love for songwriting evolved and grew naturally each time he was uprooted during his childhood years where he took advantage of a couple summers spent alone. While Duke attended the University of Missouri-Rolla, he began recording his songs in professional studios in Kansas City and playing in various college rock bands. After earning a BS in Chemical Engineering, he returned to Albuquerque, formed Primitive Edge and recorded his first album in the Norman Petty Studios under the Norvajak record label in 1986 and moved to LA to continue his life long journey of making music in 1987. He formed Plato's Lunchbox in 1991, and released, "Snack On This" in 1996. He currently owns "Saw Mill Records" where he recorded and produced his latest two original albums, "Welcome To DM Country" and "Purple Sky Outlaw". They are both available on itunes and CDBaby. Duke continues to write songs and entertain audiences with his child like energy and his love of music in the Big Bear area.
Dennis Jones Bio
Sizzling hot guitar solos. Smooth and soulful vocals. High-energy stage performance. Backed by a rhythm section that is second to none, this IS Dennis Jones. Check out a live show, and you'll instantly agree, Dennis Jones's band ROCKS the blues like NO other!
With original songs, some of which are sure to become classics, Dennis's feet are firmly rooted in the past, yet his heart and soul are connected to the present. He writes songs that seamlessly blend the best of both worlds, presenting a unique and contemporary style of American rock and blues. And unlike some others, he isn't afraid to tackle the controversial issues of today. Dennis also writes songs for other notable artists, e.g. he wrote the songTemporary Man for Guitar Shorty's 2010 Alligator release,Bare Knuckle.
Since 2003, Dennis has released four successful albums on his own label, Blue Rock Records. Each and every one of these CDs has met with rave reviews. Many of his songs and CDs have hit the top 10 on the Blues Charts, including when his 3rd CD, Pleasure & Pain, ranked #2 of best blues CD releases of the year, by the Canadian-based, Real Blues Magazine. The newly released CD, My Kinda Blues, features legendary guest musicians, Kenny Neal, and Guitar Shorty.
Dennis is no stranger to film either. Deep Blues from his first CD, Falling Up, was featured in a 2006 Lions Gate movie, Sea of Fear. The title track of Dennis's 2nd CD,Passion for the Blues, will be in the soon to be released independent film, How We Got Away With It. Finally, Dennis is one of several artists featured in the much-anticipated Babe's & Ricky's Inn, a movie about one of the oldest blues clubs in Los Angeles, and its adored owner.
The blues music industry is taking note. In May 2012, Dennis was honored to present the Awards for BB King Entertainer of the Year, to Tab Benoit, and Album of the Year, to the Tedeschi Trucks Band, for Revelator, at the Blues Music Awards in Memphis, Tennessee.
Dennis and his band continue to work hard to achieve the next level of musical success. Increased touring opportunities and greater exposure to new fans will undoubtedly make this band a household name. So if the same old blues has got you down, then it's time to check out the Dennis Jones Band!
Quick Facts about Dennis Jones…
Categories: Concerts & Tour Dates
Sorry, you missed Duke Michaels & Dennis Jone... at The Cave.
Demand that The Cave gets added to the next tour!Demand it!
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1Spray with cooking spray or grease 13x9-inch pan. In large bowl, mix cereal, pretzels and cashews.
2In 2-quart saucepan, melt candy coating over low heat, stirring constantly. Pour over cereal mixture, stirring until evenly coated. Press in pan; cool slightly.
3In microwavable bowl, microwave chocolate chips uncovered on High about 1 minute or until chocolate can be stirred smooth (bowl will be hot). Drizzle chocolate over snack. Let stand about 30 minutes or until chocolate is set. Break into clusters. Store in airtight container.


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Register Summary
When he met April 25 with thousands of pilgrims who attended his general audience in St. Peter's Square, John Paul II returned to the catechesis on prayer that he began a month ago.
The Pope focused on Psalm 63, which begins with the cry to God: "For you my body yearns; for you my soul thirsts." He said the psalmist's plea helps Christians "understand how essential and profound is the need for God."
In St. Peter's Square under a warm spring sun, the Pope asked pilgrims to picture the setting of Psalm 63: "It is dawn, the sun is rising in the clear sky of the Holy Land and the man of prayer is beginning his day by going to the temple to seek God's light.
"He has a nearly instinctive need for that meeting with the Lord — one could even say, a physical need," he said.
This hunger for God is satisfied by listening to his word and receiving the body of Christ in the Eucharist, the Pope said.
Psalm 63, on which we reflect today, is a Psalm of mystical love that celebrates total adherence to God, beginning with an almost physical longing and reaching its fullness in an intimate and everlasting embrace. Because it involves the soul and body, prayer becomes desire, thirst and hunger.
As St. Teresa of Avila wrote, "I think thirst demonstrates a desire for something, but the desire is so intense that we die if we are deprived of it" (Way of Perfection, c. XXI). The liturgy proposes to us the two first stanzas of the psalm, which are centered precisely on the symbols of thirst and hunger, while the third stanza presents the dark perspective of God's judgment against evil, which contrasts with the radiance and delight of the rest of the psalm.
We begin our meditation, then, with the first song, the song of thirst for God (see verses 2-4). It is dawn, the sun is rising in the clear sky of the Holy Land and the man of prayer is beginning his day by going to the temple to seek God's light. He has a nearly instinctive need for that meeting with the Lord — one could even say a "physical" need. Just as arid ground is dead, as long as it is not watered by rain, and just as the cracks of dried earth are like thirsty and parched mouths, so the believer longs for God — longs to be filled with him, and so be enabled to live in communion with him.
Water to Refresh the Soul
The prophet Jeremiah had already proclaimed that the Lord is "the source of living waters," and had reproached the people for having "dug themselves cisterns, broken cisterns, that hold no water" (2:13). Jesus himself would cry out in a loud voice: "Let anyone who thirsts come to me and let him drink who believes in me" (John 7:37-38). At high noon on a sunny, silent day, he promised the Samaritan woman: "Whoever drinks the water I shall give will never thirst; the water I shall give will become in him a spring of water welling up to eternal life" (John 4:14).
The prayer of Psalm 63 is linked by this theme with the song of another wonderful psalm, the 42nd: "As the deer longs for streams of water, so my soul longs for you, O God. My being thirsts for God, the living God" (verses 2-3). Now, in Hebrew, the language of the Old Testament, the term for "the soul" is "nefesh," which in some texts designates the "throat" and in many others is extended to indicate a person's whole being. Understood in this perspective, the word helps us understand how essential and profound is the need for God: Without him breath and life itself mean nothing. Because of this, the psalmist goes so far as to put physical existence itself in second place if it means he will be deprived of union with God: "Your love is better than life" (Psalm 63:4). Psalm 73 also repeats to the Lord: "None beside you delights me on earth. Though my flesh and my heart fail, God is the rock of my heart, my portion forever. … As for me, to be near God is my good" (verses 25-28).
Spiritual Food
After the lyrics on thirst, the words of the psalmist intone the song of hunger (see Psalm 63:6-9). With the images of the "rich banquet" and satiation, perhaps the man of prayer is alluding to one of the sacrifices that were celebrated in the temple of Zion: the one called the "communion" sacrifice — in other words a sacred banquet in which the faithful ate the flesh of the immolated victims. Here another fundamental need of life is used as a symbol of communion with God: Hunger is satisfied when we listen to God's Word and meet the Lord. In fact, "not by bread alone does man live, but by every word that comes forth from the mouth of the Lord" (Deuteronomy 8:3; see Matthew 4:4). And at this point a Christian's thoughts turn to the banquet that Christ prepared on the last evening of his earthly life, whose profound value he had already explained in his teaching at Capernaum: "For my flesh is true food, and my blood true drink. Whoever eats my flesh and drinks my blood remains in me and I in him" (John 6:55-56).
Through the mystical food of communion with God "the soul clings fast" to him, as the psalmist declares. Once again, the word "soul" evokes the whole human being. It is no accidentl that there is reference to an embrace, to an almost physical clinging: Now God and man are in full communion and from the lips of the creature there cannot but flow joyful and grateful praise. Even when undergoing the dark night, we feel protected by God's wings, as the ark of the covenant was covered by the cherubim's wings. And now the ecstatic expression of joy bursts forth: "In the shadow of your wings I shout for joy." Fear vanishes; and one's embrace grasps not the void but God himself; our hand is gripped by the strength of his right hand (see Psalm 63:8-9).
Christ in the Eucharist
When reading this psalm in light of the paschal mystery, the thirst and hunger that impel us toward God find their satisfaction in the crucified and risen Christ, from whom we receive, through the gift of the Spirit and the sacraments, the new life and the nourishment that sustains it.
St. John Chrysostom reminds us of this when, commenting on the observation of John the Evangelist that from the side [of Christ] "blood and water flowed out" (see John 19:34), he affirms: "That blood and that water are symbols of baptism and of the mysteries," that is, the Eucharist. And he concludes, "See how Christ unites the spouse to himself? See with what food he nourishes all of us? It is from the same food that we were formed and are nourished. Indeed, as the woman feeds the one she has generated with her own blood and milk, so Christ also continually feeds the one he himself has generated with his own blood" (Homily III Addressed to Neophytes, 16-19 passim: SC 50 bis, 160-162).


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First off, we know there's a spelling mistake in the above graphic. Second of all:
Third of all:
Ok, onto Marchand. After a Polar Vortex start to the season and some impatient fans wanting to ship his ass to Siberia for a bag of pucks and some used condoms, Brad Marchand has been on a tear for Boston. He's beena big reason why the Bs are finally coming out of their slump, too.
Yesterday against the LA Kings, Marchand registered his league leading fourth short-handed goal of the season. Beast.
Jeff Carter's controller ran out of batteries on this play.
And thanks to John (@CamFan81) we get a closer look at exactly what Marchand did.
We haven't seen so many people throw their pants off for Marchand since the Summer of the Cup.
Meanwhile, Mike Fisher doesn't feel so bad anymore.
West Coast Defense at its finest.


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Culture critic Jennifer Stone's commentary on social justice as reflected in film, television, theatre and mass media: the Zeitgeist watch.
• The cost of independent media is high. Donate today to KPFA! • Get Woke with Rising up with Sonali at 5 am, Democracy Now at 6 am, Upfront at 7 am and Democracy Now again at 9 am • For more morning news and information check out UpFront daily 7am-9am •