text:
|Publication number
|Publication type
|Application number
|Publication date
|29 Jul 2003
|Filing date
|2 Jan 1999
|Priority date
|9 Jan 1998
|Fee status
|Publication number
|Chi Yung Fu
|Original Assignee
|Chi Yung Fu
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (12), Referenced by (71), Classifications (7), Legal Events (9)
|External Links: USPTO, USPTO Assignment, Espacenet
This application claims priority of provisional application No. 60/070,284 filed Jan. 9, 1998.
The invention relates generally to chemical sensors, and more particularly to artificial olfactory sensors.
Odors are complex mixtures of chemical species, and so contain hundreds, if not thousands, of constituent molecules. The biological olfactory system is a remarkable sensor which has some very important characteristics. There are very many olfactory cells or odorant receptors, but there are not very many different types of olfactory cells. The characterization of a scent or odor is not through a specific receptor or a specific type of receptor but through the combined response of many of the receptors. In effect, the sensors respond broadly to a range or class of odors rather than to a specific one. This is the opposite to the ideal gas sensor, which responds to only one gas, and provides a unique output for a selective species. Identification of the odor is through pattern recognition in the olfactory bulb and the subsequent neural processing in the brain. In addition, the signal-processing system removes drift and may enhance the overall sensitivity of the system by as many as three orders of magnitude. The entire system is highly compact and consumes extremely low power.
Given that the human olfactory system has 100 million olfactory cells (50 million per nostril) and that each cell has ten or more cilia, each with an odor receptor, a person has a total of 1,000 million or 1 billion odor receptors. But since there are only about 1000 types of olfactory receptors, there are thus approximately 1 million identical odor receptors of each type. This high degree of redundancy could provide for an improved ratio of signal to noise.
The ability to sense odors, or identify chemical species by their odors, has a wide range of applications. It can be deployed in many major and diverse industries such as: foods (e.g., quality control for wine and coffee), cosmetics (e.g., perfume), safety (e.g., explosive detection for airlines and bacteria detection such as the E. coli), humanity (e.g., detection of landmines), medicine (e.g. detection of pneumonia and some other infections), automobile (e.g., exhaust detection for pollution and fuel efficiency), etc.
In the case of explosive detection, it is particularly important and timely because, unfortunately, almost all of the most advanced and promising detection systems have some limitations in terms of what can be detected and where they can be used. Detectors which use radiation such as X-ray and other energetic particles cannot be used on human beings. These systems are intended primarily for baggage inspection. Furthermore, these technologies have not adequately addressed non-explosive devices that deliver chemical agents and they certainly are too expensive for consumer types of applications (such as quality control for coffee and wine), not to mention that they are totally inadequate for such jobs.
Practical options of detecting dangerous substances such as explosives include the use of dogs or vapor/particle detection devices. The importance of the K-9 approach stems from the high sensitivity of the dog's olfactory system and the relatively low probability of false alarms. However, there are many limitations in using canines, including short attention span, mood changes, vulnerability to illnesses such as flu, the need to be retrained in new locations, and the apparent difficulty in finding samples placed higher than five feet. Vapor/particle detectors typically depend on classical spectrometric techniques, which rely upon the identification of specific molecules, and are not as sophisticated as the olfactory senses of animals. Thus, a suitable artificial olfactory device would provide tremendous strides in the detection of explosives and the 110 million uncleared landmines around the world since such a system will not have the same limitations at those found in the use of canines. The detection requirements for counter-terrorism and mine sweeping are quite similar. In both situations, the detection systems should be sensitive, reliable, low cost, and fast.
There have been many attempts in the past to mimic the biological olfactory system. Most of them are based on existing gas-sensor technologies and have many drawbacks. Gas sensors made from SnO2 are typical of current technology, and several commercial "electronic noses" have been based on SnO2 arrays. Platinum pellistor-type elements, similar to SnO2 sensors, require a high power consumption, which interferes with portability and low power operation.
Sensor arrays have also been made from conducting organic polymers. However, there are only a few classes of stable conducting polymers and at the present time the conducting polymers must be synthesized electrochemically, which tends to produce insoluble, intractable materials. Additional variations in the array elements have been limited to such things as varying the substituents on the polymer backbone.
The scope of conducting polymer-based sensors has recently been broadened through the use of a set of polymer blends that possess a common conducting element, polypyrrole, for signal transduction, and a variety of insulating organic polymers to achieve chemical diversity in the array. It is suspected that polypyrrole and the odor molecules incorporated into the conducting polymer act as dopants and thus produce changes in its electrical resistance. These devices function quite well, but the long-term stability of polypyrrole is of concern for practical implementation of such systems.
At the California Institute of Technology, an array of chemiresistors is used. The chemiresistors are formed of a mixture of a conducting element (e.g., carbon or polypyrrole) with a non-conducting polymer. Its detection limit currently is low but is still many orders of magnitude less sensitive than biological odor-detection systems. In addition, there are questions about the manufacturability of such sensors, since according to percolation theory, the optimal region of operation occurs at the high-gain section, which is extremely sensitive to the amount of carbon. A 1% change in the amount of carbon black can result in more than 6 orders of change in the magnitude of the resistance in that region of operation. On top of that, it also relies on a mechanism that might suffer drift or miscalibration if exposed to high concentrations, since if the swelling is great enough, the carbon grains might rearrange themselves when it shrinks back.
At Tufts University, an array of fiber-optic sensors is used as an artificial nose. The sensors contain spatially-separated photopolymers containing analyte-sensitive fluorescent indicators on an imaging fiber tip. One important advantage is that many different sensors can be built on the distal end. Though the size of each of the sensing regions is about 30 microns, thus allowing a closely-packed structure, the overall size of the sensing system is large, and more than offset the potentially small size of the fiber itself. The cited overall 60% correct prediction rate is clearly not acceptable. There is also a question on the possibility of long-term drifts of the sensitivities of these sensors, since the solvatochromic dyes are subject to continuous illumination and may react with the gases that are being sensed.
It is thus an objective to develop an artificial olfactory system to meet the above critical needs and challenges. If an artificial olfactory system can be modeled after biological systems, it has the potential to be as sensitive as its biological counterparts; as a result, one of the most important advantages is that it can be used on humans and thus could potentially detect suicide bombers. The system could also be useful for the detection of land mines, non-nitrated explosives, explosive liquids and incendiaries. The olfactory system would be capable of detecting chemicals of many kinds, provided that they have sufficient outgassing to be detected.
Specifically, it is desired to provide a low-cost, ultra-sensitive, highly miniaturized (concealable), battery-powered, electronic chemical-sensing system, that is, an artificial olfactory system that would cost about a thousand dollars or less in a package about a few cubic inches (excluding the battery) with a detection limit of 100 ppt or less without pre-concentration or less than 1 ppt with pre-concentration.
The invention is an artificial olfactory system which includes materials, methods, apparatus, and intelligent processors for the detection of odorant molecules or biological agents or any other chemical or biological species in a surrounding fluid, e.g., air. The apparatus includes a sensor having first and second conductive elements (e.g., electrical contacts) electrically coupled to a chemically or biologically sensitive acoustic device (such as a quartz crystal microbalance(QCM), surface acoustic wave device (SAW), or micro-machined resonator) which provide an electrical path between the pair of conductive elements. The acoustic device is a resonator coated with aerogel or other equivalent material (such as nanotubes, porous carbons, zeolites) or with a material formed by certain methods (such as micro-machining) to expand the detecting surface area of the uncoated resonator by a large amount (by a factor of 1000 or better). The aerogel or other surface area increasing material is coated with a polymer or equivalent material that can be tuned for the attachment of the odorant molecules or biological agents or other chemical or biological species. An indirect means to detect a biological agent is to have a reactive substance, such as appropriate protein, that reacts with the biological agent resulting in the generation of odorant molecules that can then be detected by the invention. In use, the resonator provides a difference in resonating frequencies when contacted with a fluid containing odorant molecules or biological agents at different concentrations. The artificial olfactory system uses a plurality of these sensors, each with a different response to particular odorant molecules or biological agents.
The resonating frequency is typically in the megahertz range. Variability in sensitivity from sensor to sensor is conveniently provided by qualitatively or quantitatively varying the aerogel or its equivalent materials and the polymer or its equivalent materials. For example, in one embodiment, the aerogel material in each sensor is held constant (e.g., certain type of aerogel known as xerogel) while the organic polymer varies from sensor to sensor. Arrays of these sensors are constructed with at least two sensors having different chemically sensitive polymers providing dissimilar differences in resonating frequencies. The artificial olfactory system is constructed by using such an array in conjunction with a frequency measuring device electrically connected to the conductive contacts of each sensor. The artificial olfactory systems also incorporate a variety of additional components including signal processing hardware and software to determine the identity, etc. Methods of making and using the disclosed sensors, arrays, and artificial olfactory systems are also provided.
FIG. 1A shows many discrete and separated sensing elements used to simulate the effect of the great number of cilia in a biological olfactory system.
FIG. 1B shows many discrete sensing elements of FIG. 1A aligned in an integrated unit.
FIG. 1C shows a single sensing element with greatly expanded sensing surface area to mimic the cilia in a biological olfactory system.
FIG. 2A is a top view of a sensor with electrical contacts on each end of a sensor substrate with a material with greatly expanded active sensing surface area to interact with odorant molecules on top of the substrate.
FIG. 2B is a top view of a SAW device with a material with greatly expanded active sensing surface area to interact with odorant molecules on top of the device.
FIG. 3A is a cross sectional view of a sensor having a layer of aerogel, with a polymer coating, on top of a piezoelectric crystal.
FIG. 3B shows a magnified area of the aerogel/polymer layer of FIG. 3A.
FIG. 4A illustrates the response of twelve different sensors to the same species.
FIG. 4B illustrates the response of one sensor to seven different species.
FIG. 5 shows a complete artificial olfactory system with two sensing units, a measurement unit, and a neural network or intelligent processing system.
FIGS. 6A, B are top and sectional side views of a sensor unit with six sensor elements.
The present invention attempts to mimic the functions and abilities of the biological olfactory system. While the invention is described particularly with respect to detecting odorant molecules, it more broadly encompasses detection of all chemical or biological species. Thus the term odorant molecules is generally used herein to cover any detectable species. The artificial olfactory system is based on "reproducing" the same set of characteristics as described above. As a result, it is necessary to create many identical "receptors" or sensing elements for each type of sensor. Furthermore, the sensors should respond broadly, rather than specifically as in the case of an ideal gas sensor. In addition, the system should provide advanced signal processing and intelligent information extraction as well as the ability to generalize as the biological system. And the hardware should consume very little power to allow battery operation. All these features are provided by the present invention.
There are, on the average, in the biological olfactory system, about one million identical odor receptors of each type. This redundancy is extremely important because it may be responsible for increasing the probability of "catching" the few odorant molecules and also possibly to provide this amplification through strengthening the overall response to each odor. Thus the sensor of the invention provides many identical "receptors" or sensor elements to allow this amplification and to catch odorant molecules at low concentration. A thousand, or possibly even a million, times increase in redundancy or amplification, will provide the desired level of sensitivity of the olfactory cells. To achieve such redundancy or amplification, assuming that each sensing element occupies a certain amount of area, many redundant "olfactory receptors" are provided by increasing the detection area. Aerogel technology is used to achieve a hundred-fold to possibly even a million-fold increase in surface area by expanding the sensor surface into the third dimension; the extremely high specific surface area of aerogel simulates the many redundant olfactory receptors. Other surface increasing materials which also achieve similar increases in surface area can be used in place of aerogel.
FIGS. 1A-C illustrate the principles of the invention in mimicking the large number of cilia in the biological nose. As shown in FIG. 1A, a plurality of discrete and separate sensing elements 10 are arranged to detect odor molecules 12. A distributed sensor system as in FIG. 1A cannot be made very compact. In FIG. 1B, the separate sensing elements 10 have been integrated into a single structure 14. In FIG. 1C, an equivalent sensor 16 having an increased surface area according to the present invention replaces the structure 14 of FIG. 1B, providing much higher sensitivity.
The sense of smell arises from the stimulation of the olfactory system by odorant molecules emitted from an object of interest. Odorant molecules are typically hydrophobic and polar. For example, the odor of lemons comes from Limonene, which is a single molecule. However, most natural smells are complex mixtures of chemical species and so contain hundreds, if not thousands of highly complex molecules. For example, for the monitoring of the flavor of beers, the use of conventional analytical tools (e.g., gas chromatography) is not only expensive and time-consuming but also inexact due to a lack of sensitivity or quantitative information. Many different types of olfactory cells or types of sensors are needed to respond to the many different types of odors and these sensors have to be "coupled to" or "react with" the odor molecules. Because of the polar nature of many of the odorant molecules, polymers are used in the sensor elements of the invention, since the charges of parts of the molecule can act as "handles" to which polymers could be "tuned" to specifically attach. In addition, different molecules will have different solubilities in these polymers; and the amount of swelling will also be different. These three different effects enhance the chemical diversity and thus allow detection of a broad range of smells as in the case of a biological nose. There are many different variants or types of polymers to choose from, thus allowing many types of sensors needed to make an artificial olfactory system. Thus, different types of polymers are used on aerogels for forming the different types of sensors. In addition, materials other than polymers can also be used as long as odorant molecules will attach to them.
Many techniques and devices can be used to measure the amount of attached odorant molecules. One preferred way is to measure the frequency shift of a piezoelectric crystal attached to the polymer-coated aerogel when these molecules are coupled onto that polymer. A quartz-crystal microbalance (QCM) is one type of apparatus and can detect crystal frequency shifts with an extremely high degree of sensitivity. One model claims a precision of as good as +/−0.005 Hz out of 6 MHz or about 1 part in a billion. However, any method or apparatus which can detect a change produced by attachment of the odorant molecules, e.g., any effect caused by a change in mass, stress, or swelling of the polymer film of the sensor due to adsorption, absorption, or imbibition of an odorant molecule, can be used.
Pattern recognition and intelligent signal processing are used for identifying odors with a minimum of false alarms. And among the various sorts of intelligent systems such as expert systems, artificial neural networks, and fuzzy logic, artificial neural networks and fuzzy logic are more appropriate for this application than expert systems. Thus the desired information is extracted from the inputs with neural networks, i.e., the frequency shifts in the resonant frequencies of a plurality of crystals caused by contact with different chemical species of the polymer coated aerogel attached to the crystals, are inputs into a neural network or other intelligent systems for pattern recognition signal processing.
The invention is implemented with a variety of different sensors generally based on a resonator. As shown in FIG. 2A, a sensor element 20 is formed of a substrate 22 to which a pair of electrodes 24, 26 are attached. Substrate 22 is a resonator which oscillates at a nominal resonant frequency. A layer 28 of surface area increasing material is formed on top of resonator 22. Layer 28 also contains an odorant molecule attaching material. When odorant molecules attach to layer 28, the resonant frequency of resonator 22 is changed. In FIG. 2B the sensor substrate is a particular type of resonator, a surface acoustic wave (SAW) device 30. SAW device 30 has a pair of interdigitated electrodes 32, 34. Layer 38 is similar to layer 28 of FIG. 2A.
In a first embodiment of this invention, the sensor consists of a polymercoated aerogel deposited on the surface of a piezoelectric crystal. Like the biological nose, the artificial olfactory system will have many such sensors, each with a different type of polymer or "equivalent material" responding differently to different odorant molecules. The aerogel or any material that can provide very large surface area per unit volume provides the very large surface area for the coating of the polymer, and thus effectively simulates the many same-type olfactory cells and their combined response. The sensor uses differences in the adsorption rates, solubilities of the odor molecules, and degree of swelling to ensure that a variety of different chemicals can be distinguished. A frequency shift detector forms a part of the sensor, and produces a frequency shift output signal.
As shown in FIG. 3A, a sensor element 40 is formed from a piezoelectric (PZ) crystal oscillator 42 having an aerogel/polymer layer 44 on a surface 46. A pair of electrodes 47, 48 on opposed surfaces of PZ crystal 42 are used to apply a voltage across the crystal to induce oscillation. Layer 44 provides a high surface area and the ability to capture odorant molecules. A region 50 is shown in greater detail in FIG. 3B. Aerogel substrate 52 has a thin coating of detection polymer 54 thereon. Odorant molecules 56 penetrate void spaces 58 in the aerogel substrate 52. Changes in the resonant frequency of oscillator 42 produced by different odorant molecules are detected. To indirectly detect a substance which does not provide detectable odorant molecules, a reactive material can also be included in the aerogel/polymer layer 44 (or closely nearby) whereby the substance to be detected reacts with the reactive material to produce odorant molecules as a reaction product which can then be detected by the sensor element 40.
As shown in FIG. 4A, different sensor elements (e.g., 1-12) respond differently to the same species. As shown in FIG. 4B, each sensor will have a different response to different species (e.g., 1-7). Thus, from the combination of different sensors and responses to different species, an odor signature will be obtained.
The outputs of the frequency shift detectors will be coupled with an artificial neural network for odor discrimination, and possibly for further sensitivity enhancement, as in the case of a biological nose. There are many reasons to employ artificial neural-networks (ANNs) for signal analysis. First, artificial neural networks are inherently very reliable, because like their biological counterparts, information and "knowledge" are distributed and not localized within them. As a result, local damage will not necessarily "kill" the system. Depending on its design, its performance will degrade only slowly until a substantial number of components have failed. Second, ANNs have been demonstrated to be able to extract subtle signals from a noisy environment. Third, neural networks can be used to map out the relationships between different odor signatures and the corresponding compositions as well as the quantities of each of the components in the mixture. Neural networks can go beyond routine pattern recognition. A properly designed ANN has the ability to generalize from the information it "learns" and it thus can respond correctly to unforeseen scenarios. In other words, similar to the canine, the neural network "learns" from the different odor signatures given proper training and then has the potential to generalize beyond that. The ability to generalize is extremely important because of odors from non-targets. For example, one cannot simply teach a neural network or a canine every single non-explosive odor in the world. This is significant because the FAA has repeatedly stressed the importance of minimizing false alarms. If such an alarm occurs in some major airport such as New York City's JFK Airport, it will result in panic and chaos.
From the standpoint of hardware implementation, there is another reason to employ neural-network hardware. Since most sensor outputs are analog in nature, then analog-to-digital converters are needed to interface between the sensors and the CPU if a conventional microprocessor is used. In the future, with addition to the olfactory system of more and more different types of sensors (or equivalently "types of olfactory cells"), hardware complexity, power, as well as cost will substantially increase with the conventional CPU approach. Since low-cost neural-network hardware is an inherently parallel system capable of simultaneously taking in analog signals from many sensors, e.g., 64 and these chips can be cascaded to build systems with even more inputs and outputs, it is ideally suitable for data fusion, as is required for this particular problem, and it will do so without the needs of extra hardware such as A-D converters and multiplexers, thus resulting in greater simplicity and lower cost.
As shown in FIG. 5, artificial olfactory system 60 has a pair of sensor units 62, each of which contain a plurality (e.g., 6) of sensor elements 64. The outputs of the sensor elements 64 are measured by measurement device 66. Device 66 is a frequency measurement unit, e.g., a quartz crystal microbalance, to detect frequency or mass change. Measurement device 66 produces a signature 68 which is input into an intelligent signal processor 70, e.g., a neural network that performs pattern recognition to detect, recognize and identify the odor molecules.
The most important advantages of this invention of an artificial olfactory system are its potential to achieve very high levels of sensitivity and selectivity, low cost, and small size.
A first embodiment of the electronic nose will be relatively simple, and yet reasonably compact. Off-the-shelf quartz crystals are used as the substrates for the sensors. Using one of the many proven aerogel thin-film deposition methods, a uniform and relatively thick planar xerogel film is formed on the crystal. Deposition of films with thicknesses ranging from one to greater than 200 micrometers is possible. Very uniform deposition is possible, given the relatively small area of the crystal (1.4 cm in diameter), which allows tight control. Some of the aerogels such as the xerogels have open structures while retaining relatively high porosity; this results in a relatively large specific surface area. The resulting large spacings guarantee a good coating of polymer, with sufficient leftover open structure after polymer deposition for good gas-molecule permeability.
A film with a thickness of 50 microns made from xerogel with a specific surface area of 50 sq. meter/gm and a density of 0.7 gm/cc would produce a 1750-fold increase in surface area over an uncoated surface. Since certain aerogel has been demonstrated to have a specific surface area as high as 1160 sq. meter/gm, which is a factor of 23 higher and a porosity of 98%, these parameters can easily be achieved. However, this is clearly just a starting point; through control of sol-gel polymerization, catalysts, and drying procedures, even greater amplification factors can be attained, since the manufacture of aerogels can be controlled to tailor both structure and properties. Also other materials than aerogels can be used to increase the internal surface area. For example, nanotube structures, porous carbons, or zeolites may be used.
The chemical diversity in the types of polymers can readily be obtained through the use of simply-prepared, conventional, polymers such as polydimethylsiloxane, poly(cyanopropyl)methylsiloxane, polyphenylmethylsiloxane, poly(isopropylcarboxylic acid)methylsiloxane, poly(aminopropyl) methylsiloxane, poly(vinyl acetate), poly(vinyl butyral), poly(styrene), poly(sulfone), poly(methyl methacrylate), poly(4-vinylphenol), poly(styrene-co-allyl alcohol), poly(ether urethane), poly(ethylene oxide), poly(caprolactone), poly(N-vinylpyrrolidone), poly(carbonate bisphenol A), and many others. Even more specific types of polymers can be tailored to either a wide variety or a narrow range of odors, such as those from ammunition, explosives, illegal drugs, fuel or exhaust leaks. The preparation and deposition of these polymers is relatively easy. The monomer solution can be diffused into the xerogel, where it will polymerize on the xerogel surfaces. This polymerization will be relatively easy for the coating of the xerogel's surfaces and can be controlled through dilution, catalysts, and other parameters. More sophisticated deposition methods can be used for a tighter degree of control.
Instead of polymers, any other suitable material which attaches the species to be detected can be used. For example, to detect a biological agent such as a virus, a virus attachment material such as an antibody, a protein, or a cell membrane could be used. Also polymers or other suitable materials can be modified by radiation treatments such as ultraviolet or ionic bombardment to enhance their adsorption or absorption characteristics.
For detection and measurement, each of these specially-prepared crystals is connected to equipment that monitors the oscillation of the crystal. To get very accurate measurements, equipment that continually tests and analyzes the phase-frequency relationship of the monitor crystal is used. This system generates a precise frequency and applies it to the crystal. At resonance, the angular phase difference between the applied voltage and the crystal-generated current is zero. Measuring the phase difference determines how much the frequency of the applied voltage should change; the process is repeated thousands of times a second in order to home in on the resonant frequency. The outputs of the detecting equipment will be processed by appropriate neural network algorithms running on a personal computer for odor identification and quantification. With semi-custom integrated circuit design, the bulky frequency measurement equipment (QCM) can be reduced to a single integrated-circuit chip (about 1 cm2). The personal computer running the neural network algorithms will be replaced by appropriate neural-network integrated circuit chip(s) which occupy a small area, e.g., 0.62 cm2, and thus the entire olfactory system will be extremely compact, less than a few cubic inches.
A 50-micron-thick xerogel film should not reduce the fundamental oscillation frequency too much for proper functioning of the QCM. This will depend on the density on the xerogel. A highly-condensed one with a density of 0.7 gm/cm3 will only reduce the system's fundamental frequency from 6 MHz to about 5.5 MHz, with the result that there should be no such problems coming from using such a film or even much thicker films. With even less dense aerogel films for even greater surface area the loading effect on the crystal will diminish.
Using the QCM technique, very thin films can be detected. The minimum thickness is dependent on several factors—the crystal operational frequency, the density, integration time and other factors. In the absence of the aerogel and with an integration time of 1 second assuming an extremely conservative 1-Hz detection resolution, a 6-MHz crystal can detect a thickness of 2 Å of a film with a density of 1 gm/cm3; the sensitivity improves in direct proportion to the integration time. The presence of the aerogel itself possibly makes relatively little change in the sensitivity, because of its relatively light weight, but it introduces the additional factor of a greatly expanded internal area. A xerogel with a density of 0.7 gm/cm3, an internal area of 50 m2/gm, and a thickness of 50 microns will have an internal area of 1750 cm2/cm2, a pure number, called the area multiplier. If the aerogel's internal surface was evenly coated with some adsorbed film, then the effective thickness would be the area multiplier (1750) times the true thickness, meaning that the detectable true thickness would be reduced by a factor of the area multiplier, that is, down to ˜0.001 Å.
However, it is necessary to translate this thickness detection limit into concentration. At a thickness of 0.001 Å, the adsorbed molecules are very thinly spread, and are far from achieving a maximum of coverage of the surface. This is because molecules can depart as well as arrive, and if there are insufficient arrivals, molecules depart until the departures become rare enough to be replenished by the arrivals. The state of 100% coverage of all possible adsorption sites is, of course, an asymptotic one, but the state of 50% coverage forms a convenient dividing line between the cases of poor coverage and of saturated coverage. Below that point, the amount of coverage is approximately proportional to the gas-phase concentration, while above it, the coverage goes to one. A calculation of that dividing point is obtained from water adsorbed on silica gel. The dividing point was an abundance of 2% by number of molecules at a temperature of 25� C. So if there is more than 2% of water in air, the silica gel will saturate, while if there is less than that, the amount of coverage of the silica gel will be the ratio of the abundance to 2%. At this point, the coverage fraction implied by an effective thickness of 0.001 Å must be considered. A calculation is obtained from nitrogen, a molecule of which likes to occupy an area of about 15.8 square angstroms on a surface, thus giving an equivalent thickness of about 3 Å for a material with a density of 1 gm/ cm3. If a water molecule likes to occupy a similar area, then the equivalent thickness of saturated water is 2 Å instead. This means that one can detect water if its surface coverage is only {fraction (1/2000)} of its saturation value, and if the surface has the adsorbing properties of silica gel, then one can detect 10 ppm of water vapor. For the case of detecting nitrogen dioxide, then to first order of calculation the detection limit will be about 4 ppm, because NO2 molecules are about 2.6 times more massive than those of water. Similar calculations result in detection limits of 6 ppm for NO and ˜4 ppm for CO2. Furthermore, with an ultra-sensitive QCM, such as an available one with a 0.005 Hz resolution instead of 1 Hz resolution, and with a factor of two as a safety margin, then the corresponding detection limit will be 40-60 ppb for these compounds.
Besides these estimates, a more accurate projection of the performance of the artificial olfactory system can be made using data from W. Gopel and his group in the area of using the QCM approach for the detection of numerous organic solvent vapors as well as carbon dioxide. The present invention is a significant improvement in terms of sensitivity and selectivity, because of the use of aerogels and neural-network or intelligent system technologies. Gopel's work, however, provides substantial and useful information, such as in the area of polymers. Based on his reported experimental results, a sensitivity of ˜16 ppb for chemicals such as CO2 is calculated using the present approach. This number agrees with the 40-60 ppb number derived earlier. An additional factor of 100-10,000 gain in performance can be produced by optimizing the many factors that control the overall sensor's sensitivity. For that reason, it is possible to reach a sensitivity of as low as 10 part per trillion without using preconcentration. For example, with an artificial neural network designed to operate at the level of claimed biological capability stated earlier, the sensitivity can be enhanced by three orders of magnitude. As a result, a single parameter improvement alone may give a factor 1000 improvement in sensitivity. Furthermore, the polymer used by Gopel turns out to be extremely sensitive to NO2; in fact its sensitivity is a factor of 50 times more than that of CO2. In addition, it is possible to have further enhancement of sensitivity through pre-concentration by as much as a factor of 600, as is done to increase sensitivity of various detection systems. Thus, less than one part per trillion sensitivity should be feasible. In addition, the invention can use a new approach for pre-concentration, using aerogel, which may be much simpler than that of cryogenic pre-concentration.
The issues of humidity and temperature effects can be compensated or corrected by including humidity and temperature sensors and through the use of the neural network to learn the odor patterns under various combinations of temperature and humidity conditions. These learned patterns can then be used to correct for the impact of humidity and temperature.
The invention utilizes two areas of technology to achieve the high sensitivity and selectivity, aerogel technology and neural network technology.
Aerogels, both inorganic and organic, are solid foams that can be so low in density that they are mostly empty space—no more substantial than frozen smoke. They are open-cell structures like a sponge. A xerogel is a higher density and lower porosity form of aerogel. The first aerogels—silica aerogels, highly porous forms of silica or silicon dioxide (SiO2)—were made in the 1930's, but it was not until the 1970's that they were put to practical uses. Organic (carbon-based) aerogels have a lower average atomic number than silica aerogels, and have potential advantages in certain applications. Carbon organic aerogels are the stiffest of all types.
Aerogel synthesis is basically a process of polymerization, beginning with simple molecules and bonding them together to make a giant crosslinked molecule. The production of aerogel proceeds through stages. It begins as a colloidal solution made up of a liquid within which ultrafine particles are uniformly dispersed. Its next stage is a gel, a colloidal system of liquid and solid phases that is very nearly a solid. The final phase is a low-density, highly porous solid; it is achieved by carefully drying the gel without collapsing the fragile polymer network of the solid.
In a typical solution-gel or "sol-gel" polymerization, a multifunctional monomer is polymerized in solution and proceeds through three stages:
1) The starting monomer (<1 nm in diameter) undergoes hydrolysis or addition reactions at some of its available reaction sites.
2) The substituted molecules then condense into small clusters (1-20 nm in diameter). The clusters will be polymer-like or colloid-like in structure, depending on the degree of crosslinking and the growth processes by which they were formed. They contain surface functional groups (e.g., Si—OH, and —CH2OH) that can link clusters together with covalent bonds.
3) Finally, through widespread crosslinking among clusters, a transparent gel is formed. The gel is composed of two phases—an interconnected solid and a liquid that fills the pores.
Supercritical drying of the wet gel produces the aerogel. This can be done by raising the temperature and pressure of the solvent above its critical point; in its supercritical state, the solvent becomes a gas-like fluid and can escape from the crosslinked gel network without damaging it.
The structure and properties of the final, dried aerogel are dictated by the conditions during polymerization. Factors such as the temperature, the pH of the solution (the level of acidification), the type of catalyst, and the ratio of reactant to solvent influence the crosslinking chemistry and growth processes that take place before gelation. The microstructure of the aerogel is derived from the structure of the wet gel after supercritical extraction of the solvent. Thus, by controlling the reaction conditions during polymerization, crosslinking, and supercritical solvent extraction, the structure and properties of aerogels can be extensively tailored.
To synthesize a silica aerogel, begin with a metal alkoxide (a compound formed by the reaction of a metal chloride with alcohol), which is submitted to alteration or decomposition by water (hydrolysis) and transformed from the monomer to a crosslinked gel network (condensation). Inorganic aerogels have been prepared from monomers such as tetraisopropoxytitanate, aluminum secbutylate, and zirconium isopropoxide, but mostly from the sol-gel polymerization of tetranethoxysilane (TMOS) or the less toxic tetraethoxysilane (TEOS).
Organic aerogels contain mainly carbon and hydrogen atoms and thus have a lower average atomic number (Z). In most other respects (e.g., reaction pathways, microstructure, and other properties), they are very similar to the silica aerogels. Example of organic aerogels are resorcinol-formaldehyde, melamine-formaldehyde, and carbon (obtained by pyrolyzing resorcinol-formaldehyde at 1100� C.). Resorcinol-formaldehyde aerogels can be pyrolyzed in an inert atmosphere to form pure carbon aerogels, which have improved mechanical properties and thermal expansion coefficients. During the pyrolysis cycle, the aerogels undergo substantial shrinkage as gaseous byproducts are evolved and the vitreous carbon matrix is formed. The carbon aerogels are black and opaque and are about 10 times stiffer than the uncarbonized material at an equivalent density. Increased stiffness yields improved machinability; carbonized aerogels have been machined into intricate shapes.
In most low-density materials derived from phase-separation or replication processes, structure and properties are controlled at the 1- to 100-micron scale. However, the solution chemistry of aerogels can be controlled to tailor structure and properties. Parameters such as density, surface area, cell/pore size, mechanical properties, optical transmission, refractive index, and chemical composition must be controlled in both inorganic and organic aerogels. The chief process variables that affect the structure and properties of aerogels are the type and concentration of the catalyst, the ratio of solvent to reactant, and the drying procedure.
An ultra low-density silica aerogel, an inorganic polymer foam that is nearly transparent and ghostlike in appearance, has been developed with a density of 0.003 g/cm3 (only three times the density of air) and yet it is so strong that it can support 1600 times its weight!
The structure and properties of the finished materials can be tailored by controlling the conditions during polymerization, to make strong, high-density aerogels as well as extremely transparent, ultralow-density aerogels. These materials enable the formation of sensor elements for the artificial olfactory system of the invention.
In nature, part of the functions of the olfactory bulb and the brain is to extract information from noisy signals. If the detected concentration is extremely low, then the corresponding signal-to-noise ratio coming out from the receptor cells will be poor. As a result, it will be desirable to have some signal-processing technique that can extract signals from a noisy environment. Artificial neural networks can be used to clean up noisy signals. Thus, for very low signal levels with serious interference as may be the case for very low level odor detection, which has very low signal-to-noise ratios, neural networks are well suited for signal extraction.
Once the detected signals from the sensors reach a steady stage, every sensor should theoretically give the same level of signal as a function of time. As a result, every scan on all the sensors (a snapshot in the time domain) should give the same pattern or signature except for noise. This perturbation of the signature by noise can be cleaned up first by transforming the signal into the frequency domain through Fast Fourier Transform for signal filtration, then followed by a reverse transform back into the time domain with further filtering through an auto-associative neural network. A low-pass filter gives a small improvement, but a neural-network filter achieves a much greater improvement.
In addition to signal extraction, pattern recognition and generalization from learned patterns to handle unforeseen scenarios are two other valuable aspects of neural networks. Complicated pattern-recognition tasks and the learning of input-output correlations by using neural networks to recognize different odor signatures and correlating that signature with the corresponding compound can be performed.
Very similar signatures can still be effectively identified using neural networks and other intelligent systems. A standard backpropagation neural network can be used to identify extremely similar signatures or signal patterns. A neural network can be trained to recognize signal patterns or signatures and to correlate each signature back to its corresponding causing condition. Furthermore, after training, the neural network can predict correctly from "unseen" signals.
This "self-learning" capability represents a fundamental difference between neural networks and other "intelligent" systems such as an expert system. This capability is significant, because one may actually learn from the network and gain a better understanding of the system. As more data are available, such a system may behave more and more intelligently. In addition, out of all the channels, the network can select automatically the channels in groups, possibly because it is attempting to take into account the drifts of the channels and thus when it looks for a specific signal peak, it will look not only at that particular channel but also the adjacent channels to account for drift.
With a set of training data, an intelligent system that outperforms standard neural networks can be produced. In the neural-network approach, for example, a large number of synaptic weights might be used to describe the different odor signatures. An intelligent system may use a much smaller number of parameters to achieve the same goal. Like the basic neural-network approach, these parameters are automatically generated through a learning process. Unlike traditional neural networks which learn the input-output relationship almost by "brute force", the intelligent system uses human knowledge or higher-level descriptions to enforce additional constraints, thus a more compact description. The large number of synaptic weights used by a standard backpropagation network represent a "brute force" approach with enough fitting parameters to guarantee a good "fit"; whereas the intelligent system with a much smaller number of parameters to achieve the same result should be able to generalize far better and thus learn more effectively because there is fewer degrees of freedom.
The ability to perform data fusion from many channels, to take into account the drifts of the signals, to extract signals from noisy environment, to recognize patterns or signatures and finally to generalize to unforeseen scenarios are exactly the essential attributes that one speculates that the brain and the natural olfactory system exercise during the course of processing odor recognition, and thus is an important component of the artificial neural network for the artificial olfactory system.
For signal-processing applications where real-time response and cost-to-performance and weight-to-performance ratios are important, artificial-neural-networks chips, being massively parallel and robust, are preferred. An artificial neural network chip has been developed, using thin-film resistors as artificial synapses and operational amplifiers as artificial neurons to produce customizable, very-large-scale artificial neural network chips and/or systems. A neural-network chip consists of three major components—a synaptic array, input-buffer amplifiers, and output neurons. An example is a fully-integrated, cascadable, programmable neural-network chip (0.84 by 0.74 cm2) designed to be capable of a performance of 200 million interconnects per second, having 64 input-buffer amplifiers for 64 inputs and 32 output neurons with all inputs and outputs fully connected through the synaptic array.
The chip has a number of significant advantages. For example, the inputs are high-impedance, high-current drive-buffer amplifiers to allow the chip to drive other chips, thus making the chip cascadable. This provides the foundation for building system level of performance using the chip as a building block. The synaptic array is programmable, highly uniform, densely packed, fully-connected and can accept both excitatory and inhibitory inputs. The high resistance (2 megaohm) of the synaptic technology keeps the overall power consumption very low, and the small size (10 micron by 10 micron) of the resistors representing the synapses significantly minimizes the very expensive real estate of the integrated chip, thus substantially lowering the cost of the chip, since the cost of an integrated-circuit chip increases rapidly with the size of the chip. Another unique contribution is the use of identical resistors to form synapses of different strengths. Using an 8-bit binary-weighted representation of a synapse, 256 synaptic strengths can be defined with just eight identical resistors. Thus instead of fabricating different synapses, an array of identical resistors is fabricated; greatly simplify the process. Unlike laser trimming which needs to be extremely precise to define the strength of a resistor, each synapse is defined by either leaving connected or isolating each of the eight resistors. This greatly simplifies the process of programming synaptic strength. Programming these neural networks can be easily accomplished using precision laser cutting or by more conventional integrated-circuit processing technology that employs only one mask. The laser-programming technology allows fast turnaround for rapid prototyping and insertion, on the order of hours. The conventional type of one-mask programming allows the use of more conventional semiconductor technology to program the entire wafer, laying the foundation for volume production. In addition, because the synapses are built independently of the substrate, the chip can be three-dimensional with the synapses stacked on top of the neurons. Such a 3-D structure could be cost-effective and extremely compact. In addition, the large dynamic range of the linear behavior of the synapses provides a wide margin for the design of the neurons. The 32 output neurons are capable for both excitatory and inhibitory functions, with each of the neurons capable of a programmable gain from one to 1024. This allows the great flexibility of having multiple transfer functions on a single layer, and also allows implementation of multi-layer networks on a single-layer neural network chip. The four-stage driver in each of the neurons allows high capacity to drive other circuitry.
Based on modification of the current chip, a $10 to $25 per chip before packaging with a capability of 5 billion interconnects per second is possible in the future, providing enormous data fusion, extremely fast parallel computation, intelligence, and also inherent reliability similar to biological neural networks. Though this immense amount of processing power may seem like overkill, once it is available, a general purpose olfactory system with a thousand sensors will make full use of such a powerful chip. But at least a lesser design is sufficient to address the needs of a simple artificial olfactory system intended for applications described above.
A basic system, which incorporates the principles and features described herein includes the following major components.
1) Hardware—Two six-sensor units, as shown in FIGS. 6A, B each measuring ˜3.5 inches in diameter and 2 inches thick, provide of a total of 12 sensors. Six crystals 80 are contained in a circular housing 82 in openings 84. The sensor units are integrated with the QCM equipment which is interfaced with a personal computer (PC) through appropriate data interface circuit.
2) Software—Neural networks are implemented on the personal computer (PC) for the analysis of both the detection limits and the resolving power of the olfactory system.
The entire olfactory system is a self-contained unit which consists of the two sensor units and two boxes, one for the QCM equipment and the other for the PC, each about 19 in. by 19 in. by 6 in.
From this basic configuration, more advanced configurations can be produced. Miniaturization of the quartz crystals such as using surface acoustic wave (SAW) devices or resonant micro-mechanical structures based on integrated circuit microfabrication will allow more compact and low-power devices. Thousands of types of sensors can be accommodated on a chip and thus will have even wider range of detection capabilities and improve selectivity. This IC chip approach will significantly reduce the cost to the order of $10 per chip. Improvement in detection limits will also greatly enhance sensitivity. This may be feasible as a result of structural design of the sensors, aerogels, polymers, and signal enhancement using neural networks. Examples of these are making the crystal thinner, employing SAW or micro-machined devices which can operate at much higher frequencies than bulk quartz crystals, and using appropriate aerogels which in general have much higher degrees of porosity than xerogels or other "equivalent" substance such as nanotubes, porous carbons or zeolites, thus increasing its surface area per unit volume. Simple improvement such as using much thicker xerogel films and coating both sides of the crystals will improve sensitivity by a factor of eight. Longer integration time will also enhance sensitivity. Further improvement in this sensitivity is possible through various other means such as trading off between selectivity and sensitivity by using lock-and-key systems.
The QCM equipment could be replaced by a custom-designed chip or chip set, thus again further reducing the cost and size of the system. One can implement neural-network algorithms in a digital-signal-processing chip to get the flexibility to alter algorithms as more efficient algorithms become available, or directly on a low-power neural network chip such as ours for possible battery operation.
As a result, a low-cost, ultra-sensitive, highly miniaturized (concealable), battery-powered, electronic chemical-sensing system can be provided that would cost on the order of ten to a few hundred of dollars in a package consisting of a few chips about a few cm2 (excluding the battery) with a detection limit of 100 parts per trillion or less without pre-concentration.
Changes and modifications in the specifically described embodiments can be carried out without departing from the scope of the invention which is intended to be limited only by the scope of the appended claims.
|Cited Patent
|Filing date
|Publication date
|19 Nov 1985
|5 Jan 1988
|Massachusetts Institute Of Technology
|Microelectrochemical devices
|29 Jun 1990
|5 Nov 1991
|Quantum Group, Inc.
|Biomimetic sensor that simulates human response to airborne toxins
|26 Jul 1990
|4 Feb 1992
|Kurabe Industrial Co., Ltd.
|Gas-sensitive device
|11 Sep 1990
|29 Sep 1992
|University Of New Mexico
|Molecular sieve sensors for selective detection at the nanogram level
|20 May 1993
|15 Nov 1994
|Mobil Oil Corp.
|Sensor device containing mesoporous crystalline material
|1 Feb 1993
|31 Dec 1996
|Sandia Corporation
|Coatings with controlled porosity and chemical properties
|10 Oct 1995
|15 Apr 1997
|Andelman; Marc D.
|Non-fouling flow-through capacitor
|27 May 1997
|9 Mar 1999
|The United States Of America As Represented By The Secretary Of The Navy
|Diamond or diamond like carbon coated chemical sensors and a method of making same
|16 Aug 1996
|21 Dec 1999
|The Regents Of The University Of California
|Processes for the chemical modification of inorganic aerogels
|8 Dec 1997
|4 Jan 2000
|California Institute Of Technology
|Sensor arrays for detecting analytes in fluids
|28 May 1997
|15 Feb 2000
|The United States Of America As Represented By The Secretary Of The Navy
|Method of producing a film coating by matrix assisted pulsed laser deposition
|1 Oct 1997
|18 Apr 2000
|The United States Of America As Represented By The Secretary Of The Army
|System and method for detection, identification and monitoring of submicron-sized particles
|Citing Patent
|Filing date
|Publication date
|24 Feb 2004
|14 Feb 2006
|Clemson University
|Carbon nanotube based resonant-circuit sensor
|2 Oct 2003
|30 May 2006
|University Of Florida Research Foundation, Inc.
|Application of nanotechnology and sensor technologies for ex-vivo diagnostics
|18 Aug 2005
|11 Jul 2006
|Biowarn Llc
|Methodology and apparatus for the detection of biological substances
|22 Jan 2002
|12 Sep 2006
|University Of Florida Research Foundation, Inc.
|Method and apparatus for monitoring intravenous (IV) drug concentration using exhaled breath
|10 Mar 2004
|28 Aug 2007
|Adams Jesse D
|Liquid cell and passivated probe for atomic force microscopy and chemical sensing
|31 Oct 2002
|15 Jan 2008
|The Board Of Trustees Of The Leland Stanford Junior University
|Integrated nanotube sensor
|22 Oct 2004
|30 Sep 2008
|Honeywell International Inc.
|Neuronal sensor networks
|10 Feb 2004
|21 Apr 2009
|The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Reno
|Chemical sensor with oscillating cantilevered probe and mechanical stop
|27 Jan 2004
|21 Jul 2009
|Accenture Global Services Gmbh
|Determination of the age, identification and sealing of a product containing volatile components
|30 Sep 2005
|6 Apr 2010
|Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada
|Cantilevered probe detector with piezoelectric element
|26 Nov 2003
|26 Oct 2010
|University Of Florida Research Foundation, Inc.
|Marker detection method and apparatus to monitor drug compliance
|15 Oct 2007
|21 Dec 2010
|Intoximeters, Inc.
|Methods of detecting RF interference in breath ethanol testing
|16 Nov 2005
|8 Mar 2011
|Chi Yung Fu
|Ultrasensitive olfactory system fabrication with doped aerogels
|15 Aug 2006
|29 Mar 2011
|University Of Florida Research Foundation, Inc.
|Condensate glucose analyzer
|31 Aug 2007
|18 Oct 2011
|The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration
|Nanoencapsulated aerogels produced by monomer vapor deposition and polymerization
|27 Aug 2007
|20 Mar 2012
|Board of Regents of the Nevada System of Higher Education, on Behalf of the University of the University of Nevada, Reno
|Cantilevered probes having piezoelectric layer, treated section, and resistive heater, and method of use for chemical detection
|29 Aug 2006
|3 Jul 2012
|University Of Florida Research Foundation, Inc.
|System and method for monitoring health using exhaled breath
|10 May 2005
|10 Jul 2012
|Arizona Board Of Regents
|Chemical and biological sensing using tuning forks
|2 Jul 2012
|30 Apr 2013
|Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada
|Cantilevered probe detector with piezoelectric element
|2 Jul 2012
|30 Apr 2013
|Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada
|Cantilevered probe detector with piezoelectric element
|16 Jan 2012
|3 Sep 2013
|Board Of Regents Of The Nevada System Of Higher Education
|Self-sensing array of microcantilevers for chemical detection
|26 Oct 2005
|4 Feb 2014
|Seems Inc.
|Disease diagnostic system
|15 Mar 2013
|29 Apr 2014
|Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada
|Cantilevered probe detector with piezoelectric element
|4 Dec 2012
|23 Feb 2016
|Sync-Think, Inc.
|Application of smooth pursuit cognitive testing paradigms to clinical drug development
|11 Mar 2013
|5 Jul 2016
|Sync-Think, Inc.
|Optical neuroinformatics
|29 Apr 2011
|30 Aug 2016
|Petroliam Nasional Barhad (Petronas)
|Method and system for validating energy measurement in a high pressure gas distribution network
|27 Apr 2015
|30 May 2017
|Active-Semi, Inc.
|Olfactory application controller integrated circuit
|17 Sep 2013
|18 Jul 2017
|Commissariat � l'�nergie atomique et aux �nergies alternatives
|Thermal flow sensor, gas sensor comprising at least one such sensor and Pirani gauge comprising at least one such sensor
|22 May 2002
|28 Nov 2002
|Melker Richard J.
|Method and apparatus for detecting illicit substances
|24 Jun 2002
|18 Sep 2003
|Melker Richard J.
|Method and apparatus for monitoring respiratory gases during anesthesia
|28 Jul 2003
|29 Jan 2004
|Fu Chi Yung
|Artificial olfactory system
|26 Nov 2003
|29 Apr 2004
|Melker Richard J.
|Marker detection method and apparatus to monitor drug compliance
|5 Nov 2003
|8 Jul 2004
|Bertil Hok
|Gas content microsensor
|27 Oct 2003
|8 Jul 2004
|Faris Sadeg M.
|Fluid deionization system
|27 Jan 2004
|23 Sep 2004
|Roland Hengerer
|Determination of the age, identification and sealing of a product containing volatile components
|10 Feb 2004
|13 Jan 2005
|Adams Jesse D.
|Chemical sensor with oscillating cantilevered probe and mechanical stop
|4 Jun 2004
|27 Jan 2005
|Palo Alto Sensor Technology Innovation
|Frequency encoding of resonant mass sensors
|4 Aug 2003
|10 Feb 2005
|Particle Measuring Systems, Inc.
|Method and apparatus for high sensitivity monitoring of molecular contamination
|26 Feb 2004
|10 Mar 2005
|Melker Richard J.
|System and method for therapeutic drug monitoring
|15 Jul 2004
|24 Mar 2005
|Lueck Keith W.
|Interference detection systems and methods
|24 Feb 2004
|25 Aug 2005
|Clemson University
|Carbon nanotube based resonant-circuit sensor
|20 Feb 2004
|25 Aug 2005
|Korea Advanced Institute Of Science And Technology
|Method of preparing photopolymer with enhanced optical quality using nanoporous membrane and photopolymer prepared by the same
|10 Mar 2004
|15 Sep 2005
|Adams Jesse D.
|Liquid cell and passivated probe for atomic force microscopy and chemical sensing
|1 Apr 2005
|20 Oct 2005
|Melker Richard J
|Marker detection method and apparatus to monitor drug compliance
|11 May 2004
|17 Nov 2005
|Nicolas Vezard
|Scent identification apparatus and method
|27 May 2004
|1 Dec 2005
|Glenn Claydon
|Apparatus, methods, and systems to detect an analyte based on changes in a resonant frequency of a spring element
|22 Oct 2004
|11 May 2006
|Honeywell International Inc.
|Neuronal sensor networks
|16 Nov 2005
|18 May 2006
|Chi Yung Fu
|Ultrasensitive olfactory system fabrication with doped aerogels
|22 Feb 2005
|24 Aug 2006
|Ying-Lan Chang
|System and method for implementing a high-sensitivity sensor with improved stability
|16 Dec 2005
|31 Aug 2006
|Kurup Pradeep U
|Electronic nose for chemical sensing
|15 Oct 2004
|16 Nov 2006
|Adams Jesse D
|Self-sensing array of microcantilevers for chemical detection
|25 Jul 2006
|16 Nov 2006
|Korea Advanced Institute Of Science And Technology
|Method of preparing photopolymer with enhanced optical quality using nanoporous membrane and photopolymer prepared by the same
|25 May 2005
|30 Nov 2006
|Tolliver Charlie L
|System, apparatus and method for detecting unknown chemical compounds
|10 May 2005
|20 Sep 2007
|Nongjian Tao
|Chemical and Biological Sensing Using Tuning Forks
|15 Oct 2007
|7 Feb 2008
|Intoximeters, Inc.
|Interference detector and methods
|15 Aug 2006
|21 Feb 2008
|Melker Richard J
|Condensate glucose analyzer
|30 Sep 2005
|10 Apr 2008
|Adams Jesse D
|Cantilevered Probe Detector With Piezoelectric Element
|26 Oct 2005
|17 Apr 2008
|Naoki Urushihata
|Disease Diagnostic System
|5 Feb 2010
|17 Jun 2010
|Tolliver Charlie L
|System, apparatus and method for detecting unknown chemical compounds
|27 Aug 2007
|6 Jan 2011
|Adams Jesse D
|Self-sensing array of microcantilevers chemical detection
|17 Nov 2010
|10 Mar 2011
|Intoximeters, Inc.
|Interference Detector and Methods
|17 Sep 2013
|3 Sep 2015
|Commissariat A L'energie Atomique Et Aux Energies Alternatives
|Thermal flow sensor, gas sensor comprising at least one such sensor and pirani gauge comprising at least one such sensor
|27 Apr 2015
|12 Nov 2015
|Active-Semi, Inc.
|Olfactory Application Controller Integrated Circuit
|24 Jul 2008
|9 Nov 2011
|Surface acoustic wave sensor
|17 Sep 2013
|22 Jul 2015
|Thermal flow sensor, gas sensor comprising at least one such sensor and pirani gauge comprising at least one such sensor
|21 Sep 2004
|7 Jun 2006
|Intoximeters, Inc.
|Interference detection systems and methods
|21 Sep 2004
|13 Jan 2010
|Intoximeters Inc
|Interference detection systems and methods
|11 Mar 2011
|9 Aug 2017
|Raytheon Company
|Chemical and biological sensor using atomized detection improvement agent(s)
|11 Sep 2013
|18 Mar 2015
|AIT Austrian Institute of Technology GmbH
|Graphene FET-based biosensor
|19 Nov 2004
|9 Sep 2005
|Biowarn, Llc
|Methodology and apparatus for the detection of biological substances
|19 Nov 2004
|30 Mar 2006
|Biowarn Llc
|Methodology and apparatus for the detection of biological substances
|U.S. Classification
|73/23.34, 73/24.06, 977/957
|International Classification
|Cooperative Classification
|European Classification
|14 Feb 2007
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|29 Jul 2015
|Lapse for failure to pay maintenance fees
|15 Sep 2015
|Expired due to failure to pay maintenance fee
Effective date: 20150729


text:
|Site name: PORT KEATS POLICE
|Site number: 014905
|Commenced: 1938
|Latitude: 14.24 °S
|Longitude: 129.52 °E
|Elevation: 11 m
|Operational status: Closed 17 Aug 2006
A basic site summary is available in a pdf document. This includes a graphical summary of the climate data available for the site and an operational summary. Please contact the Bureau if you have difficulties with the pdf format, or if you would like additional metadata (available for the cost of provision).
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subset: commoncrawl


text:
Early last month, during a forum in Washington, Vice President Joe Biden said the Wall Street protesters have "a lot in common with the tea party."
Whatever Biden had to drink prior before making that statement should be outlawed as a mind-altering drug.
At about the same time, House Minority Leader Nancy Pelosi made her own analysis, calling the Wall Street protest movement "young, spontaneous, and focused."
"God bless them for their spontaneity," the former House speaker told reporters.
Both of the party's biggest hitters were repeating a common refrain heard among other Democrats. Their observation is that the Occupy Wall Street movement is good for America, showing others throughout the world how our liberties - including the right to free speech - work.
Reports arrive daily, however, casting these protesters in a much different light. Behind the screen of simply taking shots at corporate America, these activists have an ideology and an agenda that is far out of the democratic mainstream.
Trying to compare these protests with the tea party assemblies is nonsense. With movements as large and widespread as the both the Wall Street and the tea party demonstrations, one can expect some bad behavior. Many in the main stream media seemed to enjoy blowing up the antics of some tea party fringe members in earlier rallies, but those incidents seemed isolated. In the massive tea party rallies we saw, crowds were well behaved and respectful of authority, even cleaning up their own litter.
That kind of conduct is a far cry from what we're seeing today. In an incident two weeks ago, a female Coast Guard officer who was walking to a train was spit on, called foul names and had a water bottle thrown at her by Occupy Boston protesters.
With capitalism as their supposed target, Wall Street protesters have been regularly engaged in outrageous behavior. One pollster, a Democrat by the way, found that a full 31 percent of the protesters were willing to commit violence in pursuit of their agenda, whatever that is.
The website biggovernment.com has compiled a list of over 100 articles from around the country, reporting on wild behavior by the Wall Street protesters, including violence, vandalism, assaults, lewd conduct such as public defecation, threats and violence against police, and even rapes.
After interviewing nearly 200 protesters in New York's Zuccotti Park, another pollster used by a Wall Street Journal columnist, showed that the movement doesn't represent unemployed America and is not ideologically diverse. Rather, the majority believed in radical redistribution of wealth, civil disobedience and, in some instances, violence.
Half of those responders said they have participated in a political movement before, nearly all (98 percent) said they would support civil disobedience to achieve their goals, and nearly one-third (31 percent) said they would support violence to advance their agenda.
He also found that the vast majority of demonstrators are actually employed and that an overwhelming majority of demonstrators supported Barack Obama in 2008.
With that kind of class war endorsement, you don't have to be a political genius to understand why the likes of Biden and Pelosi have been so understanding of these protesters.
By Jim Zbick


text:
The Destrehan girls basketball team has cruised through district play with an 8-1 record, but in order to claim a share of the league title, they must beat Hahnville on Friday in the last regular season game of the year.
Destrehan is currently tied for first place in District 8-5A with East St. John. Destrehan won the first game against ESJ but lost 56-50 last week. Hahnville is currently third in district.
"This game is extremely important because if we dont pull off a win against Hahnville then we will have jeopardized our first place ranking in district and will have to face a top ten team in the first round of the playoffs," Destrehan head coach Angi Butler said. "This would really require us to step up and play extremely well in order to move on to the second round of the playoffs."
Even through Destrehan has already beaten Hahnville once this season, Butler has been impressed with the Lady Tigers defense.
"They are a good full court pressing team," she said.
On offense, Butler said the Lady Tigers are tough to defend because they consistently feed the girls on the block to allow for the inside shot.
"In order to pull out a win we are going to have to stay mentally focused and protect the paint," she said.
Hahnville head coach Kevin Robicheaux knows that the Lady Wildcats are hard to handle because they shoot the ball so well on offense. In district play, Destrehan is averaging more than 61 points per game.
"But they also do a good job of rebounding a missed shot to get an additional opportunity to score," he said.
Robicheaux added that Destrehan is solid on defense and plays mostly zone.
"In order to win, we will have to play our best game and take advantage of any mistakes that Destrehan makes," he said. "We will have to shoot the ball well from outside and also box out and rebound on defense.
"Since it is the final game of the season, it would be nice to finish up with a victory. They beat us at their place a few weeks ago. It would be nice to win and get a split for the season."
The game is scheduled to begin a little after 6 p.m. at Hahnville.
The Destrehan and Hahnville boys basketball teams will also end the regular season by facing off against each other.
Destrehan is currently in fourth place in District 8-5A with a 3-5 record, while Hahnville is in last place with a 1-7 district mark.
Destrehans last district victory came in a 37-34 win over John Ehret on Jan. 25 while Hahnvilles lone district win came by way of a 43-42 victory over Higgins on Jan. 11.
The game is scheduled to begin at 7 p.m.
|The Lady Wildcats and Lady Tigers will face off for the second time this season on Friday. Destrehan won the first meeting between the two schools and must knock off the Lady Tigers again in order to finish in the top spot in District 8-5A.


text:
9 photos found.
Roaring River by Lilly Mybell
Roaring Fork River by Athena Helbing
Roaring River State Park 2 by Robert R. Gaines
At night the river roars by Elsa Mein
Roaring River State Park 01 by Jacob Rumsey
Roaring River State Park by Jacob Rumsey
Roaring River State Park, Fall by Robert R. Gaines
Fall Delights by Robert R. Gaines
The Flow by Dave Elmore
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New Member
Date Joined Nov 2011
Total Posts : 9
Posted 7/4/2012 7:48 PM (GMT -7)
Yesterday I noticed, for the first time, a cyst on near my wrist. I am overseas. Went to ER. They did an ultrasound. Diagnosed Ganglion cyst. No hand specialist is available for a couple of weeks and I have to travel. Can't see anyone until early August. How serious is this? I consider surgery the last resort but if needed, who does it? Orthopedic surgeon? Dermatologist?
At this point it doesn't look so bad but medical report said it has "intimate contact" with carpal joint (I am translating) which concerns me. No pain.
What options do I have? Thanks
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Regular Member
Date Joined May 2012
Total Posts : 76
Posted 7/5/2012 4:42 AM (GMT -7)
hi there...I had the same thing ganglion cyst on my left wrist, I had a orthopedist do surgery (8 years ago) he told me at the time that it could come back (it hasn't) I let mine go until I would wear a wrist brace because of pain. Good luck...
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Forum Moderator
Date Joined Apr 2005
Total Posts : 17501
Posted 7/5/2012 5:46 AM (GMT -7)
Eric, don't worry about
it. It can be taken care of. Actually, my neighbor had one and had her brother take a large book and slam it down on the cyst! It did go away and never came back.
Here is a link about
ganglion cysts to put your mind at ease. They even mention smacking it with a book! LOL They don't advise it now but that's how they took care of it years ago.
Forum Moderator/Fibromyalgia
Fibromyalgia, Crohn's Disease, Ostomy, Autoimmune Inner Ear Disease, Diabetes, Osteoporosis, Glaucoma, Scoliosis, Ankylosing Spondylitis
God does not give us a spirit of fear, but of power and of love and of a sound mind. 2 Timothy 1:7
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getting by
Forum Moderator
Date Joined Sep 2007
Total Posts : 41845
Posted 7/5/2012 6:41 AM (GMT -7)
I had two, the first one got deflated with a needle at the doctor's office, the other one I bumped and it went away. Nothing to worry about
. They use to say "hit it with a bible". Any big book would work...
Best wishes, don't worry about
Hugs, Karen
Moderator-Depression and fibromyalgia
fibromyalgia, Chronic fatigue, depression, allergies
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Screaming Eagle
Forum Moderator
Date Joined Sep 2009
Total Posts : 5005
Posted 7/5/2012 7:48 AM (GMT -7)
...I have had one for several years now. Dr said if it bothered me, he would remove it, but so far it's just a hard bump on the wist. I don't think I would go to the extreem of possibly injuring yourself by slamming a book on it though! LOL
Moderator Chronic Pain Forum
Weekly Quote!
"If you trust Google more than your doctor then maybe it's time to switch doctors"
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Veteran Member
Date Joined Jan 2011
Total Posts : 1355
Posted 7/5/2012 8:04 AM (GMT -7)
I have had a ganglion cyst on the top of my hand for years, my doctor was planning on removing it once but I helped a friend move and my hand got hit and the cyst went down. It is returning but no pain so why bother.
I wouldn't have surgery on it unless it is very noticeable and even then I would give it a wack with the phone book, o much cheaper.
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Forum Moderator
Date Joined Apr 2005
Total Posts : 17501
Posted 7/5/2012 10:34 AM (GMT -7)
Screaming Eagle, I'll be more than happy to whack that cyst with the book of your choice! I'll even whack you in other places...free of charge! I don't even charge office calls.
Forum Moderator/Fibromyalgia
Fibromyalgia, Crohn's Disease, Ostomy, Autoimmune Inner Ear Disease, Diabetes, Osteoporosis, Glaucoma, Scoliosis, Ankylosing Spondylitis
God does not give us a spirit of fear, but of power and of love and of a sound mind. 2 Timothy 1:7
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New Member
Date Joined Nov 2011
Total Posts : 9
Posted 7/5/2012 7:27 PM (GMT -7)
Thanks for responses,mostly reassuring. I was able to get an appointment with a hand surgeon (that's what they call the specialist here- Argentina) tomorrow (Friday). Will post on what he says.
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Veteran Member
Date Joined Aug 2011
Total Posts : 934
Posted 7/5/2012 8:34 PM (GMT -7)
It can be quite painful. I have had it as well. It went away on its own. The old wive's tale is to smack it with a Bible. Faith healing by violence is unnecessary lol
46F, Fibromyalgia, Vitamin D deficiency, Sleep Apnea/CPAP therapy, allergies/multiple chemical sensitivities, possible Chronic Fatigue & occasional IBS symptoms.
I take vitamins, Tramadol for pain, Flexeril as needed.
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New Member
Date Joined Nov 2011
Total Posts : 9
Posted 7/7/2012 12:30 PM (GMT -7)
Follow up: hand surgeon told me my several options, surgery is one. He said that it would involve three or four stitches, would take 20 to 30 minutes with three surgeons working together and that full recovery would be six weeks.
He did not recommend aspiration, said it seldom works.
Told me that I can try some sort of physio-therapy that is done in a clinic (ten sessions. I have to travel but when I return in early August I will start daily sessions). Also said that i can try some home therapy: put hand for five minutes in warm water, apply ice a few times a day and repeat the hot water at night.
Said that the cyst could reduce in size (or increase) but will not totally go away.
Predicted that I would probably eventually return for surgery.
Does anyone have feedback on this?
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Screaming Eagle
Forum Moderator
Date Joined Sep 2009
Total Posts : 5005
Posted 7/7/2012 1:00 PM (GMT -7)
..yes I agree with your Dr, and this is basically what mine said as well. He went on to say if it bothers the nerves and or blood vessels, then he would do surgery on it, but again that it could come back. I have left mine alone...and would never Let Dr Sherrine come within 100yrd's of it!
I'm afraid she would leave me with more lumps than I have already!
...and I'm already beat up as it is!
(side note: I personally think these are caused from patients throwing their left over med's in the trash and c
ontaminating the
,.... and not down the sink or toilet, where the wastwater can be treated)
Good luck!
Moderator Chronic Pain Forum
Weekly Quote!
"If you trust Google more than your doctor then maybe it's time to switch doctors"
Post Edited (Screaming Eagle) : 7/7/2012 2:21:35 PM (GMT-6)
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New Member
Date Joined Nov 2011
Total Posts : 9
Posted 7/7/2012 4:16 PM (GMT -7)
Who is Dr Sherrine?
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Regular Member
Date Joined Apr 2011
Total Posts : 312
Posted 7/12/2012 3:14 PM (GMT -7)
I had a large one removed from my left wrist last June. Mine was a big lump on top that had been causing increasing pain for four years and I was wearing a brace almost constantly by the end of it. One orthopedist four years ago said it was probably rheumatoid arthritis and gave me a brace, telling me to wear it whenever it hurt, but never took x-rays. I saw another one just before surgery who took x-rays, said it was definitely a ganglion coming from a tendon almost on the other (palmar) side of my wrist and that he'd be more than happy to do surgery because it'd been so painful. Mine turned out to actually be the really deep cyst with a cluster of smaller ones just underneath it coming from a tendon on the thumb side of my wrist. I have a two-inch scar on my wrist, which he said is quite long for that type of surgery. He was very glad that I'd gotten it done because if I hadn't I could have ended up with major damage to the nerves that run through my wrist. He told me there's about
a 10% chance of it returning, which it hasn't, but I do still have residual wrist pain that is probably permanent from the long-term pressure on the nerves.
My doctor was an orthopedic surgeon that specializes in wrists and hands. My family doc said that he recommends a hand specialist for anything to do with the wrist/hand due to their complexity (muscles and nerves). The ortho said that he normally offers aspiration to people but in most cases you can't even get anything out of them due to how thick the gel is inside them, and if you are able to aspirate, it comes back in better than 80% of cases. He said he definitely didn't recommend whacking it with a book.
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text: Johannesburg - The SA Air Force (SAAF) is using an auditor general (AG) report on its contract with Denel Aviation as a smokescreen to end the contract, trade union Solidarity said on Thursday."The SAAF is... hiding behind a report by the AG and is concealing the true reason for the termination of the contract," spokesman Jack Loggenberg said."If the SAAF's decision to end the contract was based solely on the AG's report, they would not have negotiated about possible solutions further."The defence department said on Wednesday the contract was terminated because the AG had declared it irregular."[Media] reports, without exception, fail to appreciate the correctness of the SAAF's termination of a contract, which was declared irregular by the AG," said defence spokesman Lt-Col Ronald Maseko."The contract dates back to a period (1986) where the current governance regime did not exist."Maseko said the AG found the contract did not comply with the Public Finance Management Act and National Treasury regulations.Loggenberg said it was "highly unlikely" that the AG had suggested ending the contract."The AG probably rather suggested that the contract be revised to comply with the relevant legislation and regulations," he said.Denel Personnel Solutions (DPS) said on January 15 that as a result of the termination, 523 Denel aircraft specialists would be retrenched.Loggenberg said at the time there was a possibility the SAAF would attempt to recruit some of the employees individually afterwards."The Air Force probably wants to end the Denel contract because it is very expensive," he said."If the Air Force were to take over some of the contracts of employment [before the retrenchments], a section 197 would have to be issued."According to section 197 of the Labour Relations Act, employees' conditions of service and remuneration must be kept on the same level when their contracts of employment are transferred to another company."It is therefore our suspicion that the Air Force, in order to save money, will wait until all the employees have been retrenched before possibly appointing some of them, on a lower salary, to do the same work," Loggenberg said.Solidarity represents 227 specialists out of the 523.


text:
Published: 05/09/2013 06:02:48 PM
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text:
'Tis the season for stone fruit at our local farmers market in the Arden-Arcade neighborhood of Sacramento, CA. A live music duo or trio keeps us movin' right along as we contemplate the picnic, pie, and frozen possibilities of our five-pound mixed bag.
'Tis the season for schlurping peaches, plums, and pluots directly over the kitchen sink and not wiping our elbows until every fiber is off the seed.
Fredericksburg, TX peaches come ripe in time for the Fourth of July. Little cubes of peach make their circuits through the paddles as Granddaddy cranks the custard. Ice and rock salt crunch between metal and wood. Cousins busy themselves, putting firecrackers down cicada holes.
August 2005: Mom and Dad brought a peck of Virginia peaches for our firstborn's arrival. On Camilla's ninth day of life Mom and I made a pie and took baby to her first picnic.
Sacramento, 2009: When we first moved here I hoped we'd find a house with fruit trees. The one we chose gets apple drop on the concrete patio from our neighbor on the right, lemons over the back fence, and an oleander (NOT edible), all white and magenta blossoms, courtesy our left-side neighbor. No peaches. I imagine those would be a mess anyway, and attract bees.
So here's to summer. What do you say, will you join me in a schlurp right now?


text:
Legal Question in Family Law in Virginia
Overturning Jurisdiction
Live in VA, and have with daughter since March 2000. Filed for custody in VA in July 2000. spouse resides in IL and was served court papers properly. Court date for VA custody was Oct 2000. I won custody, but spouse did not show. He filed for divorce in IL in late Aug 2000, whereas he included custody wants in decree. Have been fighting in IL thru attorney and now have to make an appearance for hearing in MAY 2001. I do not have money or resources to afford to go to IL or to fight any longer. Have had several court dates whereas judge has requested information in order to establish if jurisdiction in VA was warrented. All information has been given to prove my side, judge has spoken to the VA judge that presided over case, yet still will not rule because other side will not settle. I am now tied up in courts there and feel they are going to overturn jurisdiction. Do they have a legal basis to do this even though VA has already assumed jurisdiction? Can I legally get out of the court system in IL? I was told if I don't show for May hearing, I will lose and have to go thru appeals systems and start all over. HELP!
2 Answers from Attorneys
Re: Overturning Jurisdiction
It sounds like you still have the jurisdiction question open in Illinois. That needs to be settled, probably in Illinois.
You could challenge Illinois jurisdiction if and when your spouse comes to Virginia to try and enforce an order entered in Illinois. However, if you have done anything, e.g., filing pleadings acknowledging jurisdiction on this question in Illinois through your attorney. Further, if the Virginia judge has indicated an inclination to concede jurisdiction to Illinois, it would definitely be an uphill battle then.
Almost certainly the best thing to do is suck up the cost and fight jurisdiction in Illinois. Remember, even if Illinois asserts jurisdiction, that is only half the battle. You could win the other half. Additionally, there may be some, and I emphasize "some", chance of successfully challenging Illinois' jurisdiction in Virginia.
Re: Overturning Jurisdiction
The Uniforn Child Custody Jurisdiction Act(UCCJA)
should govern the outcome of this scenario, and it
would appear that the two courts are in fact working to apply it in your case as evidenced by the communucation and, presumably, the cooperation
which you have described.
Be patient, and eventually you should be able
to prevail with the court in Illinois in getting them to concede custody jurisdiction to Virginia.
If the facts are as you state, and have been accurately communicated to the Illinois court along with any other requested information, that
court in correctly applying the UCCJA should rule in your favor. That is, unless there are other facts which you haven't disclosed which would adversely reflect upon your fitness as a custodial parent or other factors which would favor the best interests of the child as being with the father in Illinois.
Nine to twelve months, or even longer, is not unusual in terms of time to resolve these kinds of
multi-jurisdictional custody disputes.
If you are unable to attend the hearing in Illinois scheduled for this May, you should detail the reasons why you cannot in a letter
to your Illinois attorney with a copy to the court. I would also attach a copy of the Virginia custody order for good measure. MH


text:
Tina Fey and Amy Poehler The Nest Set Pictures
You Have to See What Tina Fey's Crazy Character in The Nest Looks Like
Tina Fey and Amy Poehler's new movie doesn't hit theaters until late 2015, but we already have a boatload of reasons to be excited about the comedy. In the latest pictures from the set of The Nest in NYC, Fey and Poehler look primed to bring on the laughs as sisters planning a blowout party before their childhood home is sold. To kick things off, Fey does something we could only dream about as kids: standing up through the sunroof of a moving vehicle. As Fey's hair moves in the wind, Poehler has driving duties, making us wonder whether she's the more mature sister in this pairing. Other scenes find Poehler hanging out with costar John Leguizamo and Fey giving us her best badass look in a leather belt. Keep reading to see the best set pictures we've seen so far, and come back later as more snaps roll in.


text:
Professor of LawPhone: (410) 706-3549
JD, with distinction, 1994, Stanford Law School
BA, with highest honors, 1991, Yale University
Leigh Goodmark joined the Maryland Carey Law faculty in 2014 and teaches the Gender Violence Clinic, which she launched while a visiting professor here at the law school during the 2013-2014 academic year.
Previously, Professor Goodmark was the Director of the Clinical Education and Family Law Clinic and Co-Director of the Center on Applied Feminism at the University of Baltimore School of Law, where she had been a faculty member since 2003. Prior to joining the faculty at the University of Baltimore, she directed the Children and Domestic Violence Project at the American Bar Association's Center on Children and the Law. She previously taught in the Families and the Law Clinic at the Catholic University of America, Columbus School of Law. She also practiced family law in the District of Columbia at Bread for the City and Zacchaeus Free Clinic, a holistic neighborhood service center, and was the recipient of a Skadden Arps Fellowship. After graduating from Stanford Law School, Professor Goodmark clerked for the Hon. Robert G. Doumar of the United States District Court, Eastern District of Virginia.
Professor Goodmark's scholarship has appeared in numerous journals and law reviews, including the Harvard Civil Rights-Civil Liberties Law Review, Violence Against Women, Florida State University Law Review, and the Yale Journal on Law and Feminism. Professor Goodmark is a former president of CLEA and former president of the Board of Directors of the Women's Law Center of Maryland. She is a member of the Editorial Board of Violence Against Women and serves on the Advisory Board for NVRDC, a victim service organization. Professor Goodmark is a member of the Maryland, District of Columbia and California bars.
Editor, Comparative Perspectives on Gender Violence: Lessons from Efforts Worldwide (2015) (with Rashmi Goel). [Abstract]
A Troubled Marriage: Domestic Violence and the Legal System (2012). [Abstract]
Bringing the Greenbook to Life: A Resource Guide for Communities (2008) (with Ann Rosewater). [Full Text]
Reasonable Efforts Checklist for Dependency Cases Involving Domestic Violence (2008). [Full Text]
Steps Toward Safety: Improving Systemic and Community Responses for Families Experienceing Domestic Violence (2007) (with Ann Rosewater). [Full Text]
Promoting Community Child Protection: A Legislative Agenda (2002). [Full Text]
Keeping Kids Out of the System: Creative Legal Practice as a Community Child Protection Strategy (2001). [Full Text]
Should Domestic Violence Be Decriminalized?, 40 Harvard Journal of Law & Gender 53 (2017).
Freddie Gray, Law Enforcement, and Intimate Partner Violence, 16 University of Maryland Law Journal of Race, Religion, Gender & Class 173 (2016). [Full Text]
Hands Up at Home: Militarized Masculinity and Police Officers Who Commit Intimate Partner Abuse, 2015 Brigham Young University Law Review 1183. [Full Text]
"Law and Justice Are not Always the Same": Creating Community-Based Justice Forums for People Subjected to Intimate Partner Abuse, 42 Florida State University Law Review 707 (2015). [Full Text]
CONVERGEing Around the Study of Gender Violence: The Gender Violence Clinic at the University of Maryland Carey School of Law, 5 U. Miami Race & Social Justice Law Review 661 (2015). [Full Text]
Stalled at 20: VAWA, the Criminal Justice System, and the Possibilities of Restorative Justice, CUNY Law Review, Dec. 16, 2014. [Full Text]
Transgender People, Intimate Partner Abuse, and the Legal System, 48 Harvard Civil Rights-Civil Liberties Review 51 (2013). [Full Text]
Clinical Cognitive Dissonance: The Values and Goals of Domestic Violence Clinics, the Legal System, and the Students Caught in the Middle, 20 Journal of Law & Policy 301 (2012). [Full Text]
Mothers, Domestic Violence, and Child Protection: An American Legal Perspective, 16 Violence Against Women 524 (2010). [Full Text]
An Experiment in Participation, 16 The Law Teacher 12 (2009). [Full Text]
Autonomy Feminism: An Anti-Essentialist Critique of Mandatory Interventions in Domestic Violence Cases, 37 Florida State University Law Review 1 (2009). [Full Text]
Reframing Domestic Violence Law and Policy: An Anti-Essentialist Proposal, 31 Washington University Journal of Law & Policy 39 (2009). [Full Text]
When Is a Battered Woman not a Battered Woman? When She Fights Back, 20 Yale Journal of Law & Feminism 75 (2008). [Full Text]
Going Underground: The Ethics of Advising a Battered Woman Fleeing an Abusive Relationship, 75 UMKC Law Review 999 (2007). [Full Text]
The Punishment of Dixie Shanahan: Is There Justice for Battered Women Who Kill?, 55 University of Kansas Law Review 269 (2007). [Full Text]
Telling Stories, Saving Lives: The Battered Mothers' Testimony Project, Women's Narratives, and Court Reform, 37 Arizona State Law Journal 709 (2005). [Full Text]
Achieving Batterer Accountability in the Child Protection System, 93 Kentucky Law Journal 613 (2004-2005). [Full Text]
Law Is the Answer? Do We Know that for Sure?: Questioning the Efficacy of Legal Interventions for Battered Women, 23 Saint Louis University Public Law Review 7 (2004). [Full Text]
Deconstructing Teresa O'Brien: A Role Play for Domestic Violence, 23 Saint Louis University Public Law Review 253 (2004) (with Catherine F. Klein). [Full Text]
Parenting in the Face of Prejudice: The Need for Representation for Parents with Mental Illness, 36 Clearinghouse Review 295 (2002). [Full Text]
Alternative Dispute Resolution and the Potential for Gender Bias, 39 Judges' Journal 21 (2000). [Full Text]
Alternative Dispute Resolution and the Potential for Gender Bias, Judges' Journal, Spring 2000, at 21.
From Property to Personhood: What the Legal System Should Do for Children in Family Violence Cases, 102 West Virginia Law Review 237 (1999). [Full Text]
Can Poverty Lawyers Play Well With Others? Including Legal Services in Integrated, School-Based Service Delivery Programs, 4 Georgetown Journal on Fighting Poverty 243 (1997). [Full Text]
Professor Leigh Goodmark was quoted in "The NFL Set Itself Up For This," on deadspin.com.
Professor Leigh Goodmark was quoted in "Rozner: NFL, Goodell Take Shocking Stand Against Elliott," on dailyherald.com.


text:
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