text:
The Scientific World Journal
Volume 2013 (2013), Article ID 106357, 7 pages
Speciation Studies of Diorganotin(IV) Complexes with 3,3-Bis(1-methylimidazol-2-yl)propionate—Displacement Reaction by DNA Constituents
1Department of Chemistry, Faculty of Science, Islamic University, Madina 170, Saudi Arabia
2Depatment of Chemistry, Faculty of Science, Cairo University, Cairo 12613, Egypt
Received 15 August 2013; Accepted 17 September 2013
Academic Editors: M. Pellei and A. Souldozi
Copyright © 2013 Mohamed M. Shoukry and Safaa S. Hassan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The interaction of 3,3-bis(1-methylimidazol-2-yl)propionate (BIMP) with dimethyltin(IV) dichloride (DMT), dibutyltin(IV) dichloride (DBT), and diphenyltin(IV) dichloride (DPT) is investigated at 25°C and 0.1 M ionic strength in water for dimethyltin(IV), and in a 50% dioxane-water mixture for dibutyltin(IV) and diphenyltin(IV). The stepwise formation constants of the 1 : 1 and 1 : 2 complexes formed in solution are calculated from potentiometric measurements using the nonlinear least-square program MINIQUAD-75. The concentration distribution of the various complex species is evaluated as a function of pH. Displacement reactions of the coordinated 3,3-bis(1-methylimidazol-2-yl)propionate by inosine and inosine-5′-monophosphate are investigated from calculations based upon equilibrium properties.
1. Introduction
There has been tremendous research in recent years concerning the design of nonplatinum chemotherapeutics with the aim to optimize the features of classical platinum drugs constituting the basic cisplatin framework without some of their drawbacks, namely, toxic side effects, inherent intrinsic resistance, and high cost [1]. Among other noteworthy possibilities, some organotin compounds have emerged as a promising class of cancer chemotherapeutics.
The antitumour properties of tin complexes have been established since 1929 [2] and Gielen [3] has published a series of research papers on this subject during the past two decades. The diorganotin (IV) antitumour complexes showed high in vitro activity against P388 leukaemia in mice as well as in some human tumour cell lines [4–10]. Numerous diorganotin (IV) derivatives have been found to exhibit high in vivo cytotoxicity against P388 lymphocytic leukaemia and to exhibit less or no activity against other murine systems [11]. However, the new in vitro human tumour cell screening tests have once again demonstrated the potential of organotin complexes, some of which have exhibited high activity [12], and thus interest in them has been revitalized.
Organotin (IV) compounds exhibiting potent anticancer activity may act via different mechanisms at the molecular level. The binding property of organotin compounds towards DNA, the ultimate drug target molecule, depends essentially on the coordination number/stereochemistry and the nature of groups directly attached to the tin scaffold [13]. Recently, there have been reports of the interaction of Sn compounds with DNA constituents [14–16]. The antitumour activity of the coordination compounds R2SnX2L2 is controlled by the nature of R, leaving groups (X) and the ligand (L). The coordinated ligand (L) favours in some way the transport of the drugs into cells, while the antitumour activity would be exerted by the diorganotin(IV) moiety dissociated from the complex [17]. The latter would interact with nucleic acids, in a similar way as in the case of the widely used anticancer drug cisplatin. Therefore, there is a relationship between the stability of the organotin(IV) compounds and their antitumor activity. In conjunction with our previous studies on organotin (IV) complexes [18–22], the present paper aims to study dimethyl-, dibutyl-, and diphenyltin(IV) complexes with 3,3-bis(1-methylimidazol-2-yl)propionate (BIMP). The displacement reaction of coordinated (BIMP) by inosine and inosine-5′-monophosphate, taken as representative examples of DNA constituents, is investigated. The equilibrium constant for the displacement reaction is a parameter that may be significant to the antitumor activity of organotin(IV) compounds.
2. Experimental
Dimethyltin(IV) dichloride(DMT), dibutyltin(IV) dichloride (DBT), and diphenyltin(IV) dichloride (DPT) were obtained from the Merck Chem. Co. 3,3-bis(1-methylimidazol-2-yl)propionate (BIMP) was prepared as described previously [23]. Inosine and inosine-5'-monophosphate were obtained from Aldrich Chem. Co. The chemical structure of the investigated ligands were given in Scheme 1. Carbonate-free NaOH (titrant) was prepared and standardized against potassium hydrogen phthalate solution. DMT solution was prepared in water, but DBT and DPT solutions were prepared in dioxane. BIMP solution was prepared in the protonated form by dissolving in HNO3 solution.
Potentiometric measurements were made using a Metrohm 686 titroprocessor equipped with a 665 Dosimat (Switzerland). The titroprocessor and electrode were calibrated with standard buffer solutions and prepared according to NBS specifications [24]. The titrations were carried out in a purified N2 atmosphere using a titration vessel described previously [25]. The temperature was maintained constant by a Colora ultrathermostat. The protonation constants of 3,3-bis(1-methylimidazol-2-yl)propionic acid in the protonated form were determined by titrating 40 mL of a 2.5 × 10−3 M solution. The hydrolysis constants of the DMT, DBT, and DPT compounds were determined by titrating 40 mL solution of concentration 2.5 × 10−3 M of each compound. The formation constants of organotin(IV) complexes were determined by titrating 40 mL of solution containing 3,3-bis(1-methylimidazol-2-yl)propionate (2.5 × 10−3 M) and a given organotin(IV) compound with a concentration of 1.25 × 10−3 M. The titration was performed at 25°C and in water for DMT but in 50% dioxane-water solution for DBT and DPT. The in dioxane-water solution was determined as described previously [22, 26]. For this purpose, various amounts of standard NaOH solution were added to a solution containing 0.1 M NaNO3. The [OH−] was calculated from the amount of base added. The [H+] was calculated from the pH value. The product of [OH−] and [H+] was taken. The mean value obtained in this way for the log concentration product is = 15.46 for 50% dioxane-water solution. The equilibrium constants were evaluated from titration data defined by where M, L, and H represent organotin(IV), 3,3-bis(1-methylimidazol-2-yl)propionate, and proton, respectively. The calculations were performed using the computer program MINIQUAD-75 [27]. The stoichiometries and stability constants of the complexes formed were determined by trying various possible composition models. The model selected gave the best statistical fit and was chemically consistent with the titration data without giving any systematic drifts in the magnitudes of various residuals, as described elsewhere [27]. Table 1 lists the equilibrium constants together with their standard deviations as obtained from the program MINIQUAD-75. The concentration distribution diagrams were obtained using the program SPECIES [28].
3. Results and Discussion
The protonation constants of 3,3-bis(1-methylimidazol-2-yl) propionic acid were determined by direct potentiometric measurements because all protonation reactions were observed to take place within the potentiometrically measurable pH range. Protonated 3,3-bis(1-methylimidazol-2-yl)propionate behaves as a triprotic acid (H3A2+), where the differential log protonation constants in aqueous solution were found to be 2.18, 4.20, and 7.11. The first constant is corresponding to the carboxylic group and the second and third constants are corresponding to the protonated imidazole groups.
The hydrolysis of the dimethyltin(IV) cation in aqueous solution was studied by several research groups [29–33]. The potentiometric data were fitted considering the formation of the species with stoichiometric coefficients (1 0 −1), (1 0 −2), (1 0 −3), (1 0 −4), and (2 0 −2) (Table 1). The hydrolysed species may form distannoxanes with a typical 4-membered ring (SnO)2 as reported previously [34–36]. This species was not detected, which may be due the poor solubility. The dimerizing ability of the aqua-hydroxo complexes is described by the general equilibrium: The dimerization constants can be determined [19] by The potentiometric titration curves of 3,3-bis(1-methylimidazol-2-yl)propionate in the presence and absence of diorganotin(IV) are compared. The complex titration curve is significantly lower than 3,3-bis(1-methylimidazol-2-yl)propionate curve. This corresponds to the formation of a complex species through release of a hydrogen ion.
The complex formation equilibria of dimethyltin(IV) with 3,3-bis(1-methylimidazol-2-yl)propionate is characterized by fitting the potentiometric data to various models. The best model was found to be consistent with the formation of the complexes with stoichiometric coefficients (1 1 0), (1 2 0), and (1 1 −1).
The of a coordinated water molecule is calculated [18] by The calculated value is 4.77 and higher than that of water molecule coordinated to the free dimethyltin (IV) ion (3.39). This may be due to the elongation of the Sn(IV)-H2O bond caused by the coordination of 3,3-bis(1-methylimidazol-2-yl)propionate. This may be explained on the basis that coordination of the ligand will decrease the elecrophilicity of tin, and hence the coordinated water molecule will be weakly bound and consequently will be less acidic.
The concentration distribution diagram (Figure 1) shows that the species (1 1 0) is formed at low pH and predominates at pH 3.3 with an extent of formation of 46%. After pH 4.0, the monohydroxy species (1 1 −1) and hydrolysed species (1 0 −2) start to form and reach the formation percentage of 50% at pH 6.5 for (1 1 −1) species and 49% at pH 7.5 for (1 0 −2) species. The hydrolysed species (1 0 −3) is predominating after pH 10.
The hydrolysis of dibutyltin(IV) and diphenyltin(IV) ions is investigated in 50% dioxane-water solution. The potentiometric data are fitted considering the formation of the species (1 0 −1), (1 0 −2), and (2 0 −1). The monohydroxo-bridged dimer (2 0 −1) is assumed to form through dimerization of the tin(IV) via a hydroxo group, as given in (6)
where R = a butyl- or phenyl-group.
The equilibrium constant for the dimerization reaction (6) is calculated by (7) and amounts to 2.98 for dibutyltin(IV) and 4.89 for diphenyltin(IV):
The formation of the dihydroxo-bridged dimer (2 0 −2), found for dimethyltin(IV), is not favoured in the case of diphenyltin(IV) and dibutyltin(IV) ions. This may be accounted for on the basis of a steric interaction effect caused by the bulky butyl groups in the case of dibutyltin(IV) and phenyl groups in the case of diphenyltin(IV). This will cause the dimeric form (2 0 −2) to be strained and consequently energetically not favoured.
The of coordinated water molecules in dibutyltin(IV) and diphenyltin(IV) species determined in 50% dioxane-water solution are compared. The value (−log ) for diphenyltin(IV) is lower than that of dibutyltin(IV). This may be explained on the premise that the butyl group is having a higher electron donating property. This will increase the electron density on the Sn atom, and consequently the coordinated water will be weakly bound to Sn. This will make the coordinated water less acidic. However, in diphenyltin(IV), the phenyl group is having a higher electron accepting property, which will increase the acidity of the coordinated water molecule.
The potentiometric data for diphenyltin(IV) and dibutyltin(IV) complexes with 3,3-bis(1-methylimidazol-2-yl)propionate are fitted with a model composed of the species (1 1 0) and (1 2 0). The hydrolysed form of the 1 : 1 complex (1 1 −1) is not formed. This may be due to the insolubility of the latter species as a result of its electrical neutrality, and also, due to the hydrophobicity of the phenyl and butyl groups.
The concentration distribution diagram for dibutyltin(IV) complex, Figure 2, shows that the species (1 1 0) and (2 0 −1) are formed at low pH and reach a formation degree of 50% in the pH range 3–8 for (1 1 0) species and 15% at pH 4.2 for (2 0 −1) species. In the physiological pH range, the predominating species are (1 1 0) and (1 0 −1). The hydrolysed species (1 0 −2) and (1 2 0) species are formed after pH 10. From the biological point of view, it is interesting to note that the (1 1 0) species is predominating in the physiological pH range and consequently the interaction with DNA is feasible.
The concentration distribution diagram for diphenyltin(IV) complexes, Figure 3, reveals that tin(IV) is hydrolysed giving (2 0 −1) species with a maximum formation degree of 78% at pH 2.0. The complex species (1 1 0) reaches the maximum concentration of 52% in the pH range 2.8–8.0. Therefore, in the physiological pH range, the diphenyltin(IV) complex can interact with DNA constituents.
3.1. Displacement Reaction of 3,3-Bis(1-methylimidazol-2-yl)propionate Coordinated to Dimethyltin(IV) by Inosine and IMP
It was reported that DNA constituents [37, 38] have high affinity for dimethyltin(IV), dibutyltin(IV), and diphenyltin(IV), which may have important biological implications since the interaction with DNA is thought to be responsible for the antitumour activity of related complexes [39]. The antitumour activity of a diorganotin-(amine) complex is based on the displacement of the amine by DNA [40]. Consequently, the equilibrium constant for such conversion is of biological significance. Consider inosine as a typical DNA constituent (presented by HB) and 3,3-bis(1-methylimidazol-2-yl)propionate (presented by H3A2+). The equilibria involved in complex-formation and displacement reactions may be presented as The equilibrium constant for the displacement reaction is given by Substitution results in
The log value for dimethyltin(IV) complex with 3,3-bis(1-methylimidazol-2-yl)propionate [(CH3)2Sn(A)+], given in Table 1, amounts to 9.47. The corresponding log for the inosine complex with the dimethyltin(IV) ions, taken from literature [22], is 8.66. Substitution in (16) results in log . In the same way, the equilibrium constant for the displacement reaction of coordinated 3,3-bis(1-methylimidazol-2-yl)propionate by inosine-5′-monophosphate was calculated using the formation constant of dimethyltin(IV) complex with inosine-5′-monophosphate, taken from the literature [22], amounting to 11.90. The corresponding log value is 2.43. The displacement constant values indicate the ability of inosine and inosine-5′-monophosphate to displace 3,3-bis(1-methylimidazol-2-yl)propionate from its diorganotin (IV) complexes and to what extent the amine complex can interact with the DNA constituent, the main target in tumour chemotherapy. Comparison of the displacement constant values for inosine and inosine-5′-monophosphate showed that the nucleotide IMP has the higher value. This can be explained on the basis of the different columbic force of attraction between the dipositively charged diorganotin(IV) ion and IMP having extra negative charges on the phosphate group. The increase of columbic force of attraction between diorganotin(IV) and IMP will facilitate the release of coordinated 3,3-bis(1-methylimidazol-2-yl)propionate.
4. Conclusion
The present investigation describes complex formation equilibria of 3,3-bis(1-methylimidazol-2-yl)propionate with dimethyltin(IV), dibutyltin(IV), and diphenyltin(IV) ions. The results show the formation of 1 : 1 and 1 : 2 complexes. The displacement reaction of 3,3-bis(1-methylimidazol-2-yl)propionate coordinated to dimethyltin(IV) by DNA constituent as inosine and inosine-5′-monophosphate was investigated and a measure of the displacement was calculated. The results reveal to what extent DNA, the major target in tumour therapy, can displace the coordinated amine, 3,3-bis(1-methylimidazol-2-yl)propionate, and interact with dimethyltin(IV). These data are expected to contribute to the chemistry of organotin(IV) compounds as potential antitumor agents.
The authors are indebted to Professor Colin D. Hubbard for his assistance in the paper's preparation.
- A. Kotsakis, D. Hatzidaki, L. Vamvakas et al., "A retrospective analysis of non-platinum-based first- and second-line chemotherapy in patients with advanced non-small cell lung cancer," Anticancer Research, vol. 30, no. 10, pp. 4335–4342, 2010. View at Google Scholar · View at Scopus
- W. A. Collier, "Zur experimentellen Therapie der Tumoren," Zeitschrift für Hygiene und Infektionskrankheiten, vol. 110, no. 1, pp. 169–174, 1929. View at Publisher · View at Google Scholar · View at Scopus
- M. Gielen, "Organotin compounds and their therapeutic potential: a report from the organometallic chemistry department of the Free University of Brussels," Applied Organometallic Chemistry, vol. 16, no. 9, pp. 481–494, 2002. View at Publisher · View at Google Scholar · View at Scopus
- A. Yahyia, A. Et-Touhami, R. Yahyaouia, and R. Touzani, "Synthesis, characterization by means of IR, 11H, 13C-NMR and biological investigations on new diorganotin carboxylic acid derivatives," Letters in Drug Design and Discovery, vol. 7, no. 7, pp. 534–540, 2010. View at Publisher · View at Google Scholar · View at Scopus
- X. Shang, J. Wu, A. J. L. Pombeiro, and Q. Li, "Mononuclear diorganotin(IV) complexes with arylhydroxamates: syntheses, structures and assessment of in vitro cytotoxicity," Applied Organometallic Chemistry, vol. 21, no. 11, pp. 919–925, 2007. View at Publisher · View at Google Scholar · View at Scopus
- A. J. Crowe, P. J. Smith, and G. Atassi, "Investigations into the antitumour activity of organotin compounds. 2. Diorganotin dihalide and dipseudohalide complexes," Inorganica Chimica Acta, vol. 93, no. 4, pp. 179–184, 1984. View at Publisher · View at Google Scholar
- M. Gielen, C. Vanbellinghen, J. Gelan, and R. Willem, "Synthesis, characterization and antitumor activity of a series of diorganotin(IV) compounds of the type Bu2Sn(O-X-Y-O)," Bulletin des Sociétés Chimiques Belges, vol. 97, no. 11-12, pp. 873–881, 1988. View at Publisher · View at Google Scholar
- S. Tabassum and C. Pettinari, "Chemical and biotechnological developments in organotin cancer chemotherapy," Journal of Organometallic Chemistry, vol. 691, no. 8, pp. 1761–1766, 2006. View at Publisher · View at Google Scholar · View at Scopus
- N. Muhammad, Z. Rehman, S. Ali, A. Meetsma, and F. Shaheen, "Organotin(IV) 4-methoxyphenylethanoates: synthesis, spectroscopic characterization, x-ray structures and in vitro anticancer activity against human prostate cell lines (PC-3)," Inorganica Chimica Acta, vol. 362, no. 8, pp. 2842–2848, 2009. View at Publisher · View at Google Scholar
- M. Gielen and R. Willem, "Cytotoxic activity against a series of human tumour cell lines of some diorganotin(iv) 1,2-ethylenediamine N,N'-diacetates, N-(2-hydroxyethyl)- and N-(carbamoylmethyl)- iminodiacetates, and ortho-aminobenzoates," Anticancer Research, vol. 12, no. 1, pp. 269–271, 1992. View at Google Scholar · View at Scopus
- A. J. Crowe, "Antitumour activity of tin compounds," in Metal Compounds in Cancer Therapy, S. P. Fricker, Ed., pp. 147–179, Chapman and Hall, London, UK, 1994. View at Google Scholar
- M. Gielen, "Tin-based antitumor drugs," Metal-Based Drugs, vol. 1, no. 2-3, pp. 213–219, 1994. View at Publisher · View at Google Scholar
- S. K. Hadjikakou and N. Hadjiliadis, "Antiproliferative and anti-tumor activity of organotin compounds," Coordination Chemistry Reviews, vol. 253, no. 1-2, pp. 235–249, 2009. View at Publisher · View at Google Scholar · View at Scopus
- P. K. Sharma, K. Singh, S. Kumar et al., "Synthesis and anti-inflammatory evaluation of some pyrazolo[3,4-b]pyridines," Medicinal Chemistry Research, vol. 20, no. 2, pp. 239–244, 2011. View at Publisher · View at Google Scholar · View at Scopus
- Z.-U. Zia-ur-Rehman, A. Shah, N. Muhammad, S. Ali, R. Qureshi, and I. S. Butler, "Synthesis, characterization and DNA binding studies of penta- and hexa-coordinated diorganotin(IV) 4-(4-nitrophenyl)piperazine-1-carbodithioates," Journal of Organometallic Chemistry, vol. 694, no. 13, pp. 1998–2004, 2009. View at Publisher · View at Google Scholar · View at Scopus
- Z.-U. Rehman, A. Shah, N. Muhammad et al., "Synthesis, spectroscopic characterization, X-ray structure and evaluation of binding parameters of new triorganotin(IV) dithiocarboxylates with DNA," European Journal of Medicinal Chemistry, vol. 44, no. 10, pp. 3986–3993, 2009. View at Publisher · View at Google Scholar · View at Scopus
- N. Muhammad, A. Shah, Z.-U. Zia-ur-Rehman et al., "Organotin(IV) 4-nitrophenylethanoates: synthesis, structural characteristics and intercalative mode of interaction with DNA," Journal of Organometallic Chemistry, vol. 694, no. 21, pp. 3431–3437, 2009. View at Publisher · View at Google Scholar · View at Scopus
- A. S. Al Alousi, M. R. Shehata, M. M. Shoukry, and N. M. Mohamed, "Interaction of dimethyltin(IV) and trimethyltin(IV) with dehydroacetic acid," Chemical Speciation and Bioavailability, vol. 21, no. 1, pp. 1–6, 2009. View at Publisher · View at Google Scholar · View at Scopus
- A. A. Al-Najjar, M. M. A. Mohamed, M. R. Shehata, and M. M. Shoukry, "Tripropyltin(IV) complexes with some selected bioligands in 50% V/V dioxane/water mixture," Annali di Chimica, vol. 96, no. 1-2, pp. 97–107, 2006. View at Publisher · View at Google Scholar · View at Scopus
- A. A. Al-Najjar, M. M. A. Mohamed, and M. M. Shoukry, "Interaction of dipropyltin(IV) with amino acids, peptides, dicarboxylic acids and DNA constituents," Journal of Coordination Chemistry, vol. 59, no. 2, pp. 193–206, 2006. View at Publisher · View at Google Scholar · View at Scopus
- M. M. A. Mohamed and M. M. Shoukry, "Interaction of diphenyltin(IV) dichloride with some selected bioligands," Chemical and Pharmaceutical Bulletin, vol. 49, no. 3, pp. 253–257, 2001. View at Publisher · View at Google Scholar · View at Scopus
- O. Al-Flaijj, M. R. Shehata, M. M. A. Mohamed, and M. M. Shoukry, "Interaction of dimethyltin(IV) with DNA constituents," Monatshefte fur Chemie, vol. 132, no. 3, pp. 349–366, 2001. View at Publisher · View at Google Scholar · View at Scopus
- L. Peters, E. Hübner, and N. Burzlaff, "The new facial tripod ligand 3,3-bis(1-methylimidazol-2-yl)propionic acid and carbonyl complexes thereof containing manganese and rhenium," Journal of Organometallic Chemistry, vol. 690, no. 8, pp. 2009–2016, 2005. View at Publisher · View at Google Scholar · View at Scopus
- R. G. Bates, Determination of PH-Theory and Practice, Wiley-Interscience, New York, NY, USA, 2nd edition, 1975.
- M. M. Shoukry, W. M. Hosny, and M. M. Khalil, "Equilibrium and hydrolysis of α-amino acid esters in mixed-ligand complexes with N-(acetamido)-iminodiacetatecopper(II)," Transition Metal Chemistry, vol. 20, no. 3, pp. 252–255, 1995. View at Publisher · View at Google Scholar · View at Scopus
- R. J. Motekaitis, A. E. Martell, and D. A. Nelson, "Formation and stabilities of cobalt(II) chelates of N-benzyl triamine Schiff bases and their dioxygen complexes," Inorganic Chemistry, vol. 23, no. 3, pp. 275–283, 1984. View at Google Scholar · View at Scopus
- P. Gans, A. Sabatini, and A. Vacca, "An improved computer program for the computation of formation constants from potentiometric data," Inorganica Chimica Acta, vol. 18, no. 1, pp. 237–239, 1976. View at Google Scholar · View at Scopus
- L. Pettit, Personal Communication.
- G. Arena, R. Calì, A. Contino, A. Musumeci, S. Musumeci, and R. Purrello, "Coordination properties of dialkyltin (IV) in aqueous solution. Thermodynamic study of dimethyltin (IV) complexes with l-amino acids," Inorganica Chimica Acta, vol. 237, no. 1-2, pp. 187–191, 1995. View at Google Scholar · View at Scopus
- T. Natsume, S.-I. Aizawa, K. Hatano, and S. Funahashi, "Hydrolysis, polymerisation, and structure of dimethyltin(IV) in aqueous solution. Molecular structure of the polymer [(SnMe2)2(OH)3]ClO4," Journal of the Chemical Society, Dalton Transactions, no. 19, pp. 2749–2753, 1994. View at Publisher · View at Google Scholar · View at Scopus
- M. J. Hynes and M. O'Dowd, "Interactions of the trimethyltin(IV) cation with carboxylic acids, amino acids, and related ligands," Journal of the Chemical Society, Dalton Transactions, no. 3, pp. 563–566, 1987. View at Publisher · View at Google Scholar · View at Scopus
- C. de Stefano, C. Foti, A. Gianguzza, M. Martino, L. Pellerito, and S. Sammartano, "Hydrolysis of (CH3)2Sn2+ in different ionic media: salt effects and complex formation," Journal of Chemical and Engineering Data, vol. 41, no. 3, pp. 511–515, 1996. View at Google Scholar · View at Scopus
- C. Foti, A. Gianguzza, F. J. Millero, and S. Sammartano, "The speciation of (CH3)2Sn2+ in electrolyte solution containing the major components of natural waters," Aquatic Geochemistry, vol. 5, no. 4, pp. 381–398, 1999. View at Publisher · View at Google Scholar · View at Scopus
- N. Kourkoumelis, A. Hatzidimitriou, and D. Kovala-Demertzi, "The crystal structure of di-2-aminopyrimidinium tetraphenyldichloro(μ-oxo)distannate," Journal of Organometallic Chemistry, vol. 514, no. 1-2, pp. 163–167, 1996. View at Google Scholar · View at Scopus
- C. K. Chu and J. D. Murray, "Hydrolysis products of dibutyltin dichlorides," Journal of the Chemical Society A, pp. 360–367, 1971. View at Publisher · View at Google Scholar · View at Scopus
- L. Pellerito and L. Nagy, "Organotin complexes formed with biologically active ligands: equilibrium and structural studies, and some biological aspects," Coordination Chemistry Reviews, vol. 224, no. 1-2, pp. 111–150, 2002. View at Publisher · View at Google Scholar · View at Scopus
- L. Ghys, M. Biesemans, M. Gielen et al., "Multinuclear 1D and 2D NMR investigations on the interaction between the pyrimidic nucleotides 5'-CMP, 5'-dCMP, and 5'-UMP and diethyltin dichloride in aqueous medium," European Journal of Inorganic Chemistry, no. 3, pp. 513–522, 2000. View at Google Scholar · View at Scopus
- F. Arjmand, G. C. Sharma, F. Sayeed, M. Muddassir, and S. Tabassum, "De novo design of chiral organotin cancer drug candidates: validation of enantiopreferential binding to molecular target DNA and 5'-GMP by UV-visible, fluorescence, 1H and 31P NMR," Journal of Photochemistry and Photobiology B, vol. 105, no. 3, pp. 167–174, 2011. View at Publisher · View at Google Scholar · View at Scopus
- A. A. El-Tombary, Y. S. Abdel-Ghany, A. S. F. Belal, S. A. Shams El-Dine, and F. S. G. Soliman, "Synthesis of some substituted furan-2(5H)-ones and derived quinoxalinones as potential anti-microbial and anti-cancer agents," Medicinal Chemistry Research, vol. 20, no. 7, pp. 865–876, 2011. View at Publisher · View at Google Scholar · View at Scopus
- M. Nath, H. Singh, G. Eng, and X. Song, "Interaction of organotin(IV) moieties with nucleic acid constituent: synthesis, structural characterization and anti-inflammatory activity of tri-i-propyltin(IV) and diorganotin(IV) derivatives of guanosine," Inorganic Chemistry Communications, vol. 14, no. 9, pp. 1381–1385, 2011. View at Publisher · View at Google Scholar · View at Scopus


text:
Tickets are now on sale for the 2013 Greater Chattanooga Area Sports Hall of Fame induction banquet to be held Mon. Feb 25 at the Chattanooga Convention Center.
The dinner begins at 6:30 p.m.
Tickets are $35 and can be purchased through the organization's president, John Farr, at 423/875-9282. Deadline for ticket sales is Feb. 15.
The dinner includes honoring this year's hall of fame inductees as well as various special award winners including Male and Female Athlete of the Year, Betty Probasco and Walt Lauter Lifetime Achievement Awards, Allan Morris/Jim Morgan Award for Courage and the organization's highest award, the Fred Gregg, Jr Award.
November 17, 2017
November 16, 2017
Veteran baseball executive John Hart has decided to leave the Braves to pursue other interests, the club announced Friday. When the Braves introduced Alex Anthopoulos as their new executive ... (click for more)
(click for more)
Carley Braman is accustomed to being at the head of the pack, so it seems only fitting she continue her athletic career at the NCAA Division I level. For the GPS cross country team, ... (click for more)
Veteran baseball executive John Hart has decided to leave the Braves to pursue other interests, the club announced Friday. When the Braves introduced Alex Anthopoulos as their new executive vice president and general manager on Monday, it was announced Hart's role would change from president of baseball operations to special advisor. Hart, who had previously found ... (click for more)
The County School Board on Thursday night passed a resolution saying it would not sell three schools at Signal Mountain if it chooses to break away and form its own school district. Attorney Scott Bennett said the schools would still be needed and be operated for students on Waldens Ridge outside of the town of Signal Mountain. The schools are Signal Mountain Middle/High, Nolan ... (click for more)
Debate about whether to allow residents of Lookout Mountain, Ga., to keep chickens, took place at a public meeting Thursday afternoon prior to the November city council meeting. Most of the residents who spoke in favor of allowing the animals already keep them despite the town's ordinance from 1988 prohibiting the practice unless the property is at least five acres. ... (click for more)
Re: Roy Exum's "Stay, Signal Mountain, Stay" Well this article is something to think about. I think the split could go either way, and Signal Mountain schools would still flourish, as they have done for the past several years. What I'm worried about is why Signal Mountain has not yet had the guts to go be problem solvers at Howard, or Tyner, or Central. Why do ... (click for more)
I don't know what to think or who to believe in the debacle surrounding Alabama's Roy Moore and his quest for a Senate seat. I have no earthly idea what he did or how he acted 40 years ago. Heck, I can't remember what I did or how I acted 40 years ago but I do recall I kissed some minors back then. To be real honest, they were the only ones that would let me, this because I was ... (click for more)

subset: commoncrawl


text:
No, I agree he did try a bit, but it just seemed kind of hollow at that point. Maybe you're right, there really wasn't much he could do to make things better as she was so upset, but I'd want to know "why" as well.
No hometown date with EVER top Meredith and Matthew and the AV. I'll bet Mere still has nightmares.....much like the ones I have over Ben's haircut.
Kacie's htd was just beyond awkward. I could hardly watch. Whether or not she's right for Ben, I felt bad for her that her parents don't seem to trust her enough to know her own feelings. Hopefully, she can move on from this and, not only find a guy who's better than Ben, but also exert her independence. I'd also hope that her parents stop treating her like a teenager.
Ben in the Western gear? UGH. He looked like such a dweeb. The 'do wasn't helping with the cowboy hat either.
I've dated guys who dressed horribly and thought they were fashion plates. I thought they didn't know any better, but it turns out they thought they not only looked great, but had impeccable taste. I can't imagine Ben watching himself on this show and not thinking, "Man, I need to get a haircut. I didn't realize how bad my hair looks." Sadly, I'll bet he won't.
Anti-intellectualism has been a constant thread winding its way through our political and cultural life, nurtured by the false notion that democracy means that 'my ignorance is just as good as your knowledge.' - Isaac Asimov
I was thinking of the immortal words of Socrates, who said, "... I drank what?"
Finally getting to watch it online tonight.
Lindzi's date
Not much to say. Was my favorite of the night.
Kacie's date
I pretty much agree with everybody who said that her parents did good by scaring off Ben.
I'm from Texas, and although we consider Tennessee to be a Southern state, we think of it more as a hillbilly state (sorry to anybody from Tenn reading this!). When I think of Tenn, I think of Elvis, country music (which I don't like), and Granny brewing up her moonshine for Jed and the clan. As a kid, I was raised to believe "Deep South" meant places like Georgia, South Carolina, and maybe Virginia since it was one of the original colonies and home of the Confederacy.
Speaking of which, I want to comment on Kacie's father's accent. Now, don't get me wrong here. I totally respect her parents and their beliefs. In fact, I pretty much agreed with them. As a Texan, though, I just have to say that his accent made me wince. It reminded me of a West Texas accent, which is considered "the sticks" by the rest of our state.
Nicki's Date
And continuing on this snobby theme, I'm from Dallas, and around here we pretty much think that most Ft. Worther's are like Ben in his all-grown-up cowboy outfit. I will say, though, that I have visited the Stockyards and loved it, so I was glad to see it on TV.
I wonder how long Ben and Nicki kept those boots on? Real cowboy boots are uncomfortable to wear. Since they're designed to hook on a horse's stirrup, they cut into the sole of your foot. Then again, those boots that Ben wore didn't look like they had that distinctive heel. Maybe he was wearing a special pair of tenderfoot boots.
When Nicki climbed onto the bed with her mother, did anybody else think "Middle school girls at a sleepover?" That just looked weird.
Was a tad bit surprised that Nicki didn't know about her parents' wedding. As a kid I used to love looking at the photo album of my parents' wedding. I just can't believe they never talked about it all these years.
Speaking of which, was it her father who said marriage is a gamble? That really chapped my hide. Like somebody said here earlier, it's about commitment and hard work. Comparing marriage to some random thing like a crap game in Vegas is just wrong.
Courtney's Date
That was just weird seeing her with her semi-normal family. It reminded me vaguely of when a serial killer is busted and people say on the news, "But he came from such a nice family! We just don't see how this could happen!"
Notice that Courtney was still Courtney, though. She wore a dress that, er, allowed a generous view when she sat down with her mother. She also had to tug on the skirt when she sat down with her sister. Big surprise.
When Courtney was standing at the "altar," I just wanted to reach through the screen and shake her. All that fidgeting, hair tugging, etc. just drove me insane. Good thing that wasn't a real wedding or the guests would have been giving her dirty looks.
Maggie: "While she takes care of the men with the guns, why don't you sit down and I'll make you a nice, hot cup of tea?"
Pan Am stewardesses: prepared for anything!
after a decade of the bachelor, when will ABC put out "BLACK BACHELOR"!!!??? seriously this needs to happen. Black bachelor with his choosing of white/azn/black/latina ladies. Tired of watching these same ol' bland caucasians.
Just a reminder: posters are allowed to voice their opinions about the show and its participants. Calling them out or mocking them is not going to be tolerated. Please be respectful of your fellow posters!
Anti-intellectualism has been a constant thread winding its way through our political and cultural life, nurtured by the false notion that democracy means that 'my ignorance is just as good as your knowledge.' - Isaac Asimov
I was thinking of the immortal words of Socrates, who said, "... I drank what?"
You could be the juiciest, most ripe peach, but there is still going to be someone who doesn't like peaches.


text:
Professional Logo Design Or Generate Your Own Logo
This webcast discusses about professional logo design or generation of yours own logo. A logo is literally not an image but a genuine representation of a company, its vision, products and services in the best assuring manner.Watch Now
Logo Design Package Check Out This Before You Order Online
A good logo isn't that difficult to find though, when you have the utmost kind of cash, and the suitable kind of people, you don't have to go looking for wonderful logos, it's more like good logos. This webcast talks about Logo Design Package.Watch Now
Developing Corporate Logos For Construction Companies
This wecast shows that logo design should have a connection with the products and services of the business involved.Watch Now


text:
Name: Denise N. Naguib
Title: Vice President, Sustainability and Supplier Diversity
Organization: Marriott International, Inc.
Years at company: 7 years
Primary responsibilities: "I lead the sustainability strategy for global operations and drive sustainability through the design and development processes. I also am the primary communicator to our customers of our sustainability efforts."
Company's most significant sustainability-related accomplishment so far: "Our progress in rolling out Green Hotels Global, [an online environmental sustainability dashboard]. We previously did not have visibility into each individual hotel's environmental initiatives. The system is in place in 2,100 hotels as of today."
Company's most significant sustainability-related challenge: "At the individual hotel level, helping each hotel achieve a better carbon footprint number [as reported as part of Green Hotels Global]. There are places where hotels do not have access to clean energy."
BETHESDA, MD.—Denise Naguib has almost always been an environmentalist. Growing up in Egypt, she admired the beauty of the Mediterranean Sea and Red Sea. At the age of 11, after she had moved to Oregon, she wrote a letter to the governor of the state to relay her concerns about clear cutting. Today, after a career path with a number of twists and turns, Denise is one of the lodging industry's most influential green champions as vice president, Sustainability and Supplier Diversity for Marriott International.
Denise focuses on the operations side of the hotel business and reports to Marriott's senior vice president of Design and Development for Global Operations. When not traveling to industry events or other meetings, she works on multiple projects. She was the subject matter expert for Marriott's most recent Sustainability Report and recently helped roll out an environmentally responsible meeting program for The Ritz-Carlton brand.
Denise is playing a key role in the creation of the Green Hotels Global tool, an online environmental sustainability dashboard (developed and managed by The Carbon Accounting Co.). The system collects data and calculates each Marriott hotel's carbon footprint according to new industry guidelines. It also calculates each hotel's water footprint and waste diversion rate and maintains a comprehensive list of each hotel's environmental practices.
Tool Will Be Brand Standard
Denise says there are currently 2,100 Marriott properties that have completed the dashboard creation process. All approximately 3,700 properties will be in the system by March 2013. Utilizing the Green Hotels Global tool will be a brand standard for all Marriott properties.
For the last 18 months Denise and others at Marriott have been working with MindClick SGM in support of the MindClick Hospitality Sustainability Performance Index (HSP Index). The HSP Index measures suppliers' corporate social responsibility, environmental operations, and product sustainability efforts. Marriott just announced that it will spend 75 percent of its 2013 furniture, fixtures and equipment (FF&E) budget with suppliers that are part of the Index.
"We know that in order to get more vendors in the rating system (there are currently 23 suppliers, two architect/design firms, three purchasing companies, and one other company participating), we needed to put a stake in the ground," Naguib says. So far, Marriott is the only hotel brand that has committed to using the Index.
Strong History of Supporting Diverse Suppliers
Ensuring that Marriott's supplier base is as diverse as possible is also part of Denise's job. Her goal is to get diverse-owned suppliers to bid on Marriott business. She says she will be hiring a small team of employees to support that effort. Marriott has put a lot of attention on supplier diversity in the past. Marriott is an active corporate member of multi-national organizations that support the development of diverse and historically excluded suppliers and collaborates with companies such as Avendra to help it reach its supplier diversity goals. According to Marriott's recent Sustainability Report, it has spent nearly $4 billion over the last decade with diverse suppliers.
Prior to working in her current position, Denise worked as senior director, Sustainability for Marriott. Earlier, she was corporate director, Environmental Programs for The Ritz-Carlton Hotel Company and led environmental strategy for the brand. She got her start with Marriott in 2005 when she moved to the Cayman Islands to implement Jean-Michel Cousteau's Ambassadors of the Environment program at The Ritz-Carlton, Grand Cayman. The program's success led The Ritz-Carlton Hotel Company to sign a 10-year agreement with Jean-Michel Cousteau to implement these programs at various properties throughout the brand. Denise is a LEED Green Associate and is pursuing LEED Accredited Professional for Existing Buildings.
When asked what she enjoys most about her job, Denise says, "I love having the ability to educate and influence leaders around the subject of sustainability."
Go to Marriott International.
Glenn Hasek can be reached at email@example.com.


text:
Expand Your Development Skills With Creative Tech Projects
- By Christian Bäuerlein
- August 23rd, 2009
- 40 Comments
Even if you're an experienced Web developer, your next project doesn't have to be a website. Sometimes doing something outside of the usual Web developer's box is more fun and can even be educational. We'll try here to give you some inspiration on what to do on your next rainy day.
You can learn a lot by doing something other than building or designing a website. And if you stick with techniques that you can learn in a couple hours, you won't burden yourself either.
Think Work Outside The Box Link
As a Web developer, you have to constantly summon creativity and empathize with users. If you have a natural flare for design and usability, that's great. But our work can sometimes become inflexible and boring. We can lose our enthusiasm to try new things. To avoid this trap, we can strive to gain new insight by putting our common tools aside and exploring projects beyond the Web developer's usual environment.
Experimenting with new ways of creating applications and interfaces and even building a hardware controller will lend fresh insight into our own field and make us see the techniques we use day after day with new eyes.
It is also a good way to become more sensitive to usability issues. If you work all day at the computer, you probably cannot understand how a technically inexperienced 85-year-old person feels when they visit your website for the first time. You can't because your experience with using a keyboard and mouse is so natural.
The best way to get that feeling back — to feel what it's like to have to click and play around with an interface to figure out how to use it — is to build your own hardware controller or a new kind of interface. Being the one who has to fix these fundamental problems will make you much better at identifying what elements make for a comfortable interface.
Your future Web development will surely benefit from the insights and innovation you bring back. So get out and play around with other tech stuff and recharge your batteries! We've put together some suggestions here for you. You may already have heard of some of them and perhaps even planned on taking action on them. If so, hopefully this article will motivate you to actually get on it! If you know of any interesting tools not listed below, please let us know in the comments.
Write Your Own Desktop Application Link
Doesn't sound very exciting, but every developer should create a desktop application once in their life… even if the only lesson they learn is that they should stick to developing websites.
If you are not familiar with any programming languages for desktop applications and are not interested in learning one, you could still create a local application using one of the following tools.
Adobe AIR Link
See this round-up of resources for Adobe AIR7 that appeared on Smashing Magazine.
Shoooes Link
If you are a Ruby-ist or want to become one, Shoooes9 (currently offline) might interest you. It's an easy-to-learn cross-platform toolkit for writing small apps in Ruby. If you want to learn the joy of programming, this could be a good entry point.
Extend Firefox Link
You don't have to set up a standalone application, though. If you use Firefox, why not play around with Greasemonkey10, Ubiquity or Jetpack?
You can extend your favorite Web pages with AJAX functionality or even create your own toolbar with useful plug-ins. Hint: if you create a great Greasemonkey script, you can convert it to a Firefox extension11 on the fly.
Create Interfaces For Your Favorite Gadget Link
iPhone Link
Two good starting points are this demo15 of multi-touch events and this example showing a more detailed usage case. With the possibility of GPS positioning16 and storing offline content17, the potential for amazing iPhone-specific Web applications is huge. By the way, if you want to create an iPhone app, have a look at Phonegap18: it's like Adobe AIR for mobile phones.
Nintendo Wii Link
The Opera-powered Internet channel of the Wii console offers a supplementary JavaScript object that holds information such as the position of the pointer and pressed buttons for up to four connected WiiMotes. If you want to impress your non-techie friends by bringing your own multi-player Wii game to the next party, try this out.
There are also some code examples20 and a demo application21.
Nabaztag Link
The Nabaztag23 bunny is surely one of the best Internet-related gadgets around. Even though it's a little unusual, no list of customizable gadgets would be complete without it. Nabaztag owners adore the little bunny so much, so it is common for them to tailor special gear and costumes for it.
In case you don't want to go this far, there's also a Web-based API that you can use as a remote control for your little friend. Make Nabaztag speak and move with any programming language that can send an HTTP request.
Play With Hardware Link
WiiMote Link
The WiiMote24 is an impressive piece of hardware. It's able to track infrared light and has acceleration sensors for all three axes. Best of all, you can connect it to your computer via Bluetooth. There are libraries in many programming languages such as Java25 (here26 and here) and even Flash27 that let you use the WiiMote as a controller or receiver so that you can create features like multi-touch, gesture recognition and head tracking.
Look on YouTube28 to see what's possible.
Arduino Link
If you want to create your own hardware, check out the Arduino boards30. Whether you want to build a touch-screen device, a robot or an intelligent sweater, a lot of extensions are around that make it easy for you to assemble a hardware device that fits your needs.
Of course, a lot of other solutions are around, including USB experimental kits (available at any electronics dealer). But the easy extensibility of Arduino's components make for a relatively easy yet powerful start in hardware programming.
Lego Mindstorms Link
Though made by the same company, Mindstorms32 does not have much in common with those miniature colored bricks you played with as a kid. Mindstorms is a collection of plug-and-play components, such as servo motors and light sensors, that you can use to build a robot or other device easily. The interesting part is that you can define the robot's behavior using a visual interface, so you don't have to do any coding at all if you don't want to.
Discover New Ways To Create And Visualize Link
Visualizing data and creating virtual and augmented realities is a big challenge and also a chance to create something very personal and outstanding. Processing33 is a toolkit for creating visualizations in a simplified Java language. It is popular because it supports access to external devices via USB and Bluetooth.
The combination of Papervision3D34 and FLARToolKit35 might interest Flash developers. They enable you to create augmented realities in Flash using a Web cam and printed barcode. Even developers who usually don't work in Flash should check them out. These two libraries really make Flash worth another look.
Other notable projects are the vvvv toolkit36 for visual programming and OSCulator37 for sound effects.
Combine Everything! Link
Keep in mind that these are not necessarily standalone suggestions. You'll surely get more innovative ideas if you combine this hardware and software with each other or with tools you normally use. A lot of blogs out there may provide further inspiration, including Hacked Gadgets38.
Footnotes Link
- 1 http://www.adobe.com/products/air/
- 2 http://www.adobe.com/de/products/air/
- 3 http://seesmic.com/
- 4 http://tweetdeck.com
- 5 http://extjs.com/
- 6 http://www.adobe.com/de/products/flex/
- 7 https://www.smashingmagazine.com/2009/04/07/adobe-air-developers-toolbox-resources-and-tutorials
- 8 http://shoooes.net/
- 9 http://shoooes.net/
- 10 http://www.greasespot.net/
- 11 http://arantius.com/misc/greasemonkey/script-compiler
- 12 http://developer.apple.com
- 13 http://developer.apple.com/safari/library/documentation/AppleApplications/Reference/SafariJSRef/index.html
- 14 http://webkit.org/blog/386/3d-transforms/
- 15 http://www.sitepen.com/blog/2008/07/10/touching-and-gesturing-on-the-iphone/
- 16 http://developer.apple.com/safari/library/documentation/AppleApplications/Reference/SafariWebContent/GettingGeographicalLocations/GettingGeographicalLocations.html
- 17 http://developer.apple.com/safari/library/documentation/iPhone/Conceptual/SafariJSDatabaseGuide/Introduction/Introduction.html
- 18 http://phonegap.com/
- 19 http://www.nintendo.com/wii
- 20 http://ajaxian.com/archives/the-wii-remote-api-now-your-userbase-is-four
- 21 http://wiioperasdk.com/
- 22 http://www.nabaztag.com
- 23 http://www.nabaztag.com
- 24 http://en.wikipedia.org/wiki/Wiimote
- 25 http://code.google.com/p/wiiusej/
- 26 http://motej.sourceforge.net/
- 27 http://code.google.com/p/wiiflash/
- 28 http://www.youtube.com/results?search_query=wiimote
- 29 http://arduino.cc
- 30 http://arduino.cc
- 31 http://www.ni.com/academic/mindstorms
- 32 http://mindstorms.lego.com/eng/Overview/default.aspx
- 33 http://processing.org/
- 34 http://code.google.com/p/papervision3d/
- 35 http://www.libspark.org/wiki/saqoosha/FLARToolKit/en
- 36 http://vvvv.org/
- 37 http://www.osculator.net
- 38 http://hackedgadgets.com


text:
Friendship Forged in Fire: British Ceramics in America
Hardcover, 59 Pages
Price: $35.95
Prints in 3-5 business days
The essays in this book look at the development of British Ceramics and their collection by American collectors. The historic 'special relationship' between Great Britain and the United States spans decades and is deeply valued on both sides of the 'pond.' Emerging from the alliances forged in the world wars in the first half of 20th century, both British and American societies have benefited from the infusion of each other's cultural contributions. Ceramics and ceramic collecting has been no different in this regard. The British ceramic art displayed in this book is largely loaned from the private collections of California connoisseurs. These treasured artifacts testify to the regard and appreciation that American collectors hold for British ceramics. This catalog accompanies the 2013 exhibition by the same name at the American Museum of Ceramic Art in Pomona, CA.
Ratings & ReviewsLog in to review this item
There are no reviews for the current version of this product
There are no reviews for previous versions of this product
Product Details
- Copyright
- The American Museum of Ceramic Art (Standard Copyright License)
- Edition
- Second Hardcover
- Publisher
- American Museum of Ceramic Art
- Published
- March 28, 2013
- Language
- English
- Pages
- 59
- Binding
- Hardcover (casewrap)
- Interior Ink
- Full color
- Weight
- 0.77 lbs.
- Dimensions (inches)
- 8.25 wide x 10.75 tall
Your notification has been sent
Lulu Staff has been notified of a possible violation of the terms of our Membership Agreement. Our agents will determine if the content reported is inappropriate or not based on the guidelines provided and will then take action where needed.
Thank you for notifying us. We will email you with the results and/or actions taken as a result of the investigation if you chose to receive confirmation.
We were unable to complete your request.
We were unable to complete your request.
Listed In
More From
Age Verification
The page you are attempting to access contains content that is not intended for underage readers.
Please verify your birth date to continue.


text:
If an item you ordered from TextbookRush does not meet your expectations due to an error on our part, simply fill out a return request and then return it by mail within 30 days of ordering it for a full refund of item cost.
Learn more about our returns policy
Limited time offer:
Get the first one free! (?)
All the information you need in one place! Each Study Brief is a summary of one specific subject; facts, figures, and explanations to help you learn faster.
List price: $136.88Edition: 7thCopyright year: 2004Publisher: McGraw-Hill Higher EducationBinding: HardcoverSize: 8.25" wide x 10.00" long x 0.75" tall Weight: 2.992Language: English
Born in France and educated in France and Switzerland, Ferd held an M.S. degree from the Sorbonne and an Sc.D. degree in theoretical mechanics from the University of Geneva. He came to the United States after serving in the French army during the early part of World War II and had taught for four years at Williams College in the Williams-MIT joint arts and engineering program. Following his service at Williams College, Ferd joined the faculty of Lehigh University where he taught for thirty-seven years. He held several positions, including the University Distinguished Professors Chair and Chairman of the Mechanical Engineering and Mechanics Department, and in 1995 Ferd was awarded an honorary Doctor of Engineering degree by Lehigh University.
Born in Philadelphia, Russ holds a B.S. degree in civil engineering from the University of Delaware and an Sc.D. degree in the field of structural engineering from The Massachusetts Institute of Technology (MIT). He taught at Lehigh University and Worchester Polytechnic Institute (WPI) before joining the faculty of the University of Connecticut where he held the position of Chairman of the Civil Engineering Department and taught for twenty-six years. In 1991 Russ received the Outstanding Civil Engineer Award from the Connecticut Section of the American Society of Civil Engineers.
*A minimum purchase of $35 is required. Shipping is provided via FedEx SmartPost®
and FedEx Express Saver®. Average delivery time is 1 – 5 business days, but
is not guaranteed in that timeframe. Also allow 1 - 2 days for processing. Free shipping is eligible only in the continental United States and excludes
Hawaii, Alaska and Puerto Rico. FedEx service marks used by permission."Marketplace"
orders are not eligible for free or discounted shipping.
Learn more about the TextbookRush


text:
March 31, 2012
November 24, 2011
July 4, 2011
July 4, 2011
Hey there football fan! I'm Lee Johnson and you have found your way to my Bleacher Report page. For the last few years I have been writing at my all football site, Football Jabber, as well as hosting and co-hosting fantasy football podcasts. Much of that time was spent providing free fantasy football information and analysis to the owners out there looking for that extra push to win their championship. I like to take an approach to helping beginners become self-sufficient, and giving experienced fantasy players that extra edge as if we are hanging out in the same room. Humor and logic make a an excellent concoction. Most recently I have returned to the fantasy football game with FantasyFootballScheme.com
Any word on the Fantasy Football Dynasty 101 rulebook?
Hey I Got Fantasy Football First Year Of The Keeper League and Second Year of the league Want to join
I'm finally a Featured Columnist now! Please check out my latest article, it's a little different because I did it blog style and another bonus article on fantasy football.
Please provide your excellent feedback!
Adrian Peterson is arguably the best running back in the NFL. Even as an Eagles fan, I love to watch him play.
But the Vikings better be sure not to overwork him in the upcoming years...
There's still another year of football left to be played this decade.
But it's never too early for a list. Here is my NFL All-Decade team, position by position. Let me know what you think...
Remember Leon Lett's blunder in the Super Bowl? And Thanksgiving? Today he is in the news, but for something much more noteworthy. Please check out my new article, and let me know what you think. Thanks, Michael
Just finished an article about how the AFC North's rivalries impact the teams playoff chances.
I poured my heart and soul into this one, taking a nice look back at the road I've traveled down, I'd be very appreciative if you checked it out my friend.
I had more fun writing this article than just about any I have ever written. It is a compilation of the ten best articles I have ever read on Bleacher Report. I would love if you would check this out. Thanks!


text:
View Single Post
Has some friends
Join Date: Aug 2009
Location: Everett
Posts: 201
Originally Posted by
This is a very good topic about info not getting out. We are looking for better ways to do some things since times have changed. In your opinion how can the PNW4WDA get the info out better?
Thanks and welcome to the forum!
That's a deep question and I'm no one to tell you how to run your board. It's just a observation on my part that a new person has to dig deep for what little info is here....I'm speaking mostly about the competition side of things. There are lots of links here for legal matters and trails type info I think or maybe it's just that I'm more familliar with that stuff so it seems more complete...
As far as the competition thing is concerned I guess you first have to know if you even want to attract new people, that's up to you veterans. If you do maybe a link to a page explaining the different events and some of the specifics about the events. The tech/ rules page needs LOTS of work. I've competed in many aspects of racing 4wd and different organizations with different rules but I can barely make heads or tails or your tech requirements. To make matters worse when you show up for tech and don't have a typical comp rig there's much confusion from the guys doing the tech. They're probably not used to seeing different types rigs either.
Once you get past all of this there's much fun to be had that makes it all worth while.
View Public Profile
Send a private message to Binder
Find all posts by Binder


text:
Celebrating Dickens
November 23, 2010
This holiday season, Mid-Continent Public Library is celebrating Charles Dickens with a special series of programs featuring his classic A Chirstmas Carol. The series includes library favorite David zum Brunnen's performance of A Night Before... A Christmas Carol, a lecture from Dickens scholar Dr. Elliot Engel, and a return to the area from Gerald Dickens, the great-great-grandson of Charles Dickens. The performances run November 29 - December 15. Registration is required for all events.
Night Before Christmas Carol
Branch: Antioch
November 29, 2010 - 10:00am
Branch: Boardwalk
November 29, 2010 - 7:00pm
Branch: Midwest Genealogy Center
November 30, 2010 - 10:00am
Branch: Colbern Road
November 30, 2010 - 7:00pm
Join Charles Dickens in his study for a very special night. On this evening in 1843, he creates his holiday classic, "A Christmas Carol". Renowned Dickens scholar, author, playwright and lecturer, Elliot Engel has crafted a work that allows David zum Brunnen to portray the 17 Christmas Carol characters and Charles Dickens himself. Recommended highly by the Dickens family, MCPL is privileged to offer this performance to continue its Dickens' tradition!
Discovering Dickens with Dr. Elliot Engel
Graceland University Auditorium, 1401 W. Truman Road
December 8, 2010 - 7:00pm
Come hear from one of the most engaging Dickens scholars around delve a bit deeper into the man who wrote "A Christmas Carol". Dr. Engel has written ten books published in England, Japan, and the United States. His mini-lecture series on Charles Dickens ran on PBS television stations around the country. His articles have appeared in numerous newspapers and national magazines inducing "Newsweek". He has lectured throughout the United States and on all the continents including Antarctica. Four plays which he has written have been produced during the last ten years. For his thirty years of academic work and service in promoting Charles Dickens, he was nominated and inducted into the Royal Society of Arts in England. Dr. Engel now lives in Raleigh, North Carolina, where he has taught at the University of North Carolina, North Carolina State University, and Duke University. Since 1980, Dr. Engel has been President of the Dickens Fellowship of North Carolina, the largest branch of this worldwide network of clubs. The sales of Dr. Engel's books, CDs, and DVDs have raised funds for "The Great Ormond Street Children's Hospital" which Dickens helped found in London in 1852.
A Christmas Carol With Gerald Dickens, A Special Engagement
Branch: Raytown
December 15, 2010 - 2:00pm
Branch: Blue Springs South
December 15, 2010 - 7:00pm
Returning to MCPL is Gerald Dickens, the great-great grandson of Charles Dickens for a special engagement. A professional actor in England, the energetic Gerald Dickens leaps, laughs, and sobs as he portrays the voices of A Christmas Carol. His striking resemblance to his great-grandfather and his dramatic rendition of A Christmas Carol bring the classic to life.
Refreshments will be served.
These performances are offered in partnership with The Elms Resort in Excelsior Springs. Library performances are free. Gerald is also performing at a special tea or dinner on December 16th. Contact The Elms at (816) 630-5500 for those tickets.
Tags: holiday, event
Gerald Dickens Returns!
I'm ridiculously excited for this event. It's September 25th today. My birthday is Sunday, so in a weird way, it's like happy birthday and Christmas.


text:
use google chrome. it functions awesome
whos the blonde haired school gal? she is freakin hot
Guys:many tube xxx sites don`t have free download link.Just can watch.Get orbit downloader freeware,install it,open it on bar below.Open Grab++,play your vid and then click on GET IT! I use Orbit always,log in or not.Get also Flash Player 9 or 10 from Adobe
just download it right away..
too good
http://www.spankwire.com/Russia-Institute-School-Many-Hot-Chick-1-3/video145466/ PART I
where is part 1???
who is that nurse? She is hot!!!
I can't download, but before it was moving crazy slow. Any solutions?
i can`t dwen lode
Video still doesnt work for me even though i have firefox and flash and everything installed.
just curious, anyone know why the girl's feet are censored at like 25:45?
i had the same problem. I downloaded firefox and installed it. It works fine on firefox but on internet explorer its still asking for the flash... so i dont know whats causing it but thats my solution, download and install firefox
i have no problem watching the videos. i just have a standard account. maybe its a browser issue. im using firefox
you can if you go premium,as a standard account u have to download, type in the generated number and then click on download. yeah i know its gay and lame.
Thought it was me being stoopid has anyone got the vids working yet I have rebooted 3 times.
Theres taking the piss and then theres taking the piss...why cant i and so many others get to see these vidoes rather than this fucking get adobe flash player bullshit appearing everytime!!! It cant get anymore downloaded or it'd be in my lap!!! Some ppl dont even have this problem, what the fucks going on?? Someone???...
Server must be having issues--I can't download any porn today. :-(
i had same problem with vid...you need to reboot system
how do i download. or do i need platinum
vid thing... also having many probs with the playing thing... I've downladed flash player like 1000 times
i can't seem to to play any vids can anybody help me all i get is the adobe icon and when i download it nothing happens can anybody help me Please
Related Videos
Recognize someone?
Help improve Spankwire by telling us who
the stars are in this video.
Thank You!
Pornstars are added once we get
enough submissions with the same name.
Privacy Policy | Terms of Use | 18 U.S.C. 2257 | Contact | DMCA | RTA | FAQ | Feedback | Mobile version | Sitemap


text:
Palestinian President Mahmoud Abbas' security forces have significantly widened a crackdown on Hamas in the West Bank in the past month, doubling the number of detainees and increasingly targeting wives of activists, school teachers and others on the fringes of the Islamic militant group, Hamas officials say.
In the same period, police in Hamas-ruled Gaza have picked up dozens of Abbas loyalists, said officials in Abbas' Fatah movement.
The bitter rivals accuse each other of using the recent sweeps for political leverage, as they try to negotiate an elusive power-sharing deal and the terms of general elections in January. A Palestinian unity government is seen as crucial to U.S. efforts to restart Israeli-Palestinian peace talks, since Israel says it can't make concessions to the divided Palestinians.
Tit-for-tat detentions have been carried out over the two years since Hamas overran Gaza, ousting the forces loyal to Abbas, who was left with just the West Bank. Since then, each side has being trying to assert more control and wipe out the rival's power base, amid persistent allegations of mistreatment of detainees.
Since June 2007, Abbas' security forces – fearful of a Hamas takeover in the West Bank – detained hundreds of Hamas activists, closed Hamas-run charities and dried up the group's funding.
Hamas legislator Mahmoud Ramahi said this week that there has been a sharp spike in detentions, from 460 in custody at the end of May to a total of 887 behind bars a month later, a new record.
"June was a crazy month for detention," Ramahi said. "It's clear that they (Fatah activists) want to put political pressure on the movement by forcing it to accept Fatah's conditions for reconciliation and to control the movement's activities."
Several Abbas aides dismissed the Hamas allegations of political arrests. They claimed this week that the militants were involved in plots to attack Palestinian security compounds and government officials in the West Bank, but provided no evidence.
A Hamas list of names of detainees given to The Associated Press showed that among them were several university professors and mosque leaders, seven municipal council members, school teachers and at least five journalists for Hamas-affiliated media outlets.
Fifty have been held for nine months or more and only six have been put on trial, where all were convicted of weapons possession, Ramahi said.
Dr. Farid Abu Dheir, a journalism teacher at Al Najah University in the West Bank city of Nablus, said he was held for five days in June, and asked whether a press office he runs receives Hamas funding. He said investigators showed him confessions of activists they said detailed the structure of Hamas institutions and funding.
In the town of Tulkarem, 17-year-old high school student Sameh Qarout was taken from his home by Palestinian military intelligence on June 24 and grilled for three days about his friends, said his father, Sadiq, adding that the boy had just left the hospital after having his appendix removed when he was detained.
The detainees also included a 68-year-old doctor known for involvement with Islamic charities, two Nablus businessmen and five women, two of whose husbands are also detained.
A high ranking Palestinian security official said Hamas members are often released after they hand over money, weapons and information. The arrests seek to "strip Hamas of its weapons and financial nets, to keep the movement powerless and unable to repeat its military coup in the West Bank," he said. He spoke on condition of anonymity because he was not authorized to speak to reporters.
Abbas and his security chiefs insist that only those suspected of security offenses are detained.
West Bank police spokesman Adnan Damiri said the Palestinian Authority has about 400 detainees, some of them held for hours or days. Not all are put on trial, he said. Most of the arrests stem from three charges, he said: weapons possession, money laundering and "incitement" against the Palestinian Authority.
One of the arrested women and her husband were caught hiding 1 million euros for Hamas. Another female detainee is suspected of hiding fugitives and a third threw a hand grenade during clashes between Hamas militants and Palestinian security forces, he said.
In Gaza, Hamas-controlled security forces have systematically gone after political rivals, mainly those from Fatah.
This week, coinciding with the latest round of reconciliation talks in Cairo, more than 100 Abbas loyalists were picked up in Gaza, bringing the number of detainees to more than 300, said Fahmi Zaghrir, a Fatah spokesman. He said several dozens have been held for months.
The Gaza-based Palestinian Center for Human Rights said some of those summoned for questioning were told to wait for hours in the hot sun without water or food. The group said most were released after interrogation.
Hamas Interior Ministry spokesman Ehab Ghussein said several dozen were in detention on security-related charges, but denied any were political prisoners.
Researcher Salah Mousa from the West Bank-based Independent Commission for Human Rights said both sides have carried out political arrests.
"Hamas is trying to wipe out Fatah in Gaza and Fatah is trying to wipe out Hamas in the West Bank," he said.
Associated Press writers Ben Hubbard and Dalia Nammari contributed to this report from Ramallah.


text:
592 Governor Chittenden Road , Williston, 05495 Stati Uniti d'America
Although Jim's been making these muffins for decades, the name originated from a funny tale involving two bran muffins, a jog in the woods, a bed & breakfast guest and a mishap... he was locked inside the outhouse out on the trails! All ended well, but it makes for a fun story! Ask Jim to make these muffins for you & tell you about Tom's Adventure!


text:
Trending Forward: Award Show EditionHow to rock a red carpet even if you're not a celebrity.
J-Lo and James Corden Carpool KaraokeLopez was the guest for Corden's prime time special.
Interview: Jennifer Lopez Tells Carson Daly What Fans Can Expect From Her New Album
AMP Music Minute: Pitbull Album Details, Ne-Yo Gets Animated
Style Evolution: Jennifer Lopez Goes From Fly Girl To Hip MommyJ. Lo sure has come a long way since that barely there Versace number.
Top Five Singers Turned Fashion DesignersThese stars made it easy to copy their style by creating their own fashion lines.
J.Lo Goes 3D, Gets 'InStyle'The singer is currently filming a concert movie and graces the cover of the September issue of 'InStyle.'
J.Lo is a Mom First, Everything Else SecondJennifer Lopez seems to do it all, but the multi-hyphenate superstar says mom is the only job that really matters to her.
Colbie Caillat On Why She Won't Join "American Idol" As JudgeThe singer-songwriter admits she's thought about being a judge but says she has plans to open an animal shelter instead. But she's a huge JLo fan.
'Idol' Shake Up: Who Will Take Over For J.Lo and Steven Tyler?With both Jennifer Lopez and Steven Tyler saying goodbye to American Idol last week, we round up the rumored candidates who are competing to fill their shoes.
J.Lo Readies Greatest Hits CollectionIt's hard to believe it's been nearly 13 years since Jennifer Lopez released her debut album, 'On the 6.' It's even harder to imagine that in that same amount of time she's managed to release seven records. To commemorate both of these milestones, J.Lo is putting out her first greatest hits collection.
AMP Music Minute May 7th


text:
Blair Tindall
Fourth season later this year!
My Works
Selected Works
Los Angeles Times
Parallel careers
Des Moines Register
Sexual harassment
Sydney Morning Herald
Musicians n' Drugs
Los Angeles Times
Oliver Sacks interview
Financial Times
The Song Lines
Los Angeles Times
Wonderful instruments
Los Angeles Times
Amateurs fiddle around
Los Angeles Times
Killer weed!
New York Times
Orchestra bosses' $$$
New York Times
Women conductors
New York Times
Stage fright drugs
New York Times
Girls gone wild
New York Times
Buy yourself an opera
Dubya's nuking your hometown
Fast trains v. air shuttles
California tidepools
Yoga Journal
Palo Alto Weekly
Psychedelic Palo Alto
San Francisco Examiner
What crawls into 24-hour Fitness at 3 a.m.?
Quick Links
Grove/Atlantic Press
The MacDowell Colony
Tindall on Alex Ross's blog
Read about Tindall and Johnson O'Connor
Ucross Foundation
Tindall on public radio's "The Infinite Mind."
KHN Center for the Arts
Stanford Journalism
Authors Guild
For press and speaking inquiries, contact email@example.com
Blair with show creator Jason Schwartzman at the Golden Globes
Atlantic Monthly Press,
June 2005, paper 2006Now in Amazon Kindle format!
"Mozart in the Jungle: Sex, Drugs, and Classical Music" by Blair Tindall, a journalist and recovering oboist, which despite a pandering title actually contains the smartest and most constructive take on the situation.
--The New Republic, Oct. 22, 2007
In the tradition of Anthony Bourdain's "Kitchen Confidential" and Gelsey Kirkland's "Dancing on my Grave" comes an insider's look into the secret world of classical musicians.
From her debut recital at Carnegie Recital Hall to the Broadway pits of "Les Miserables" and "Miss Saigon," Blair Tindall has played with some of the biggest names in classical music for twenty-five years. Now in "Mozart in the Jungle," Tindall exposes the scandalous rock and roll lifestyles of the musicians, conductors, and administrators who inhabit the insular world of classical music.
Tindall's "Jungle" travels around the globe, from performances in Vienna's Staatsoper, Rio's Teatro Colon and a remote Brazilian rainforest, then on to New York City, where she and her musician colleagues live in the squalor of a decrepit west side tenement. A metaphor for the classical music business, the building has fallen from glory, its elaborate stone carving chipped, windows patched with cardboard, and its elegant décor plastered over by a greedy landlord and her predatory handyman. Outsiders have never looked farther than the ornate facade…until now.
Inside, music transforms a schoolteacher into a beautiful diva, and sustains a renowned pianist who endures two heart transplants to perform with the stars who pay him a pittance. An American goddess of the arts struggles to fulfill a dream, her ominous future mirrored by an older musician whose fantasies drain away in her lonely apartment upstairs. A stunning cellist becomes an AIDS-infected crack addict and prostitute; a Metropolitan Opera violinist is jailed for selling cocaine; and an African-American virtuoso becomes so lost inside the elitist white arts world that he smashes his $185,000 eighteenth-century French violin into splinters.
The drama of "Mozart in the Jungle" opens during America's Cold War-era optimism, and follows four musicians as their world dissolves into a culture of entitlement for a new generation of classical musicians, who are deaf to changing American tastes and demand. By weaving memoir with investigative arts journalism, Tindall shatters rhetoric about the arts in the United States -- in an real-life tale from a musician whose career paralleled America's late twentieth-century culture boom. As "Mozart in the Jungle" races to its dramatic conclusion, Tindall reveals music as a simple, spiritual gift accessible to all.


text:
Rapper Lupe Fiasco was escorted off the stage at an inaugural party last night after spending 30 minutes on an anti-war song, Politico reports.
Now This News shows Fiasco dropping lines critical of President Obama before the lights went off and security escorted him off the stage.
Full News here – Taegan Goddard's Political Wire


text:
Mills watches video of Lyon's rough outing
Mills watches video of Lyon's rough outing
HOUSTON -- Astros manager Brad Mills spent some time following Saturday's 6-3 loss watching video of Brandon Lyon's rough outing against the Braves. Lyon allowed four runs without recording an out in the 10th inning in his second appearance since being activated from the disabled list.
"The big thing that struck me last night was locating those pitches, and I think he would probably say the same thing," Mills said. "When the catcher is setting up away and the pitch winds up over [the plate], something's different. That's not him."
Lyon missed 32 games with right biceps tendinitis and a partial rotator cuff tear and returned to action Friday and gave up a home run in one inning.
"Maybe he's getting a feel for it," Mills said. "We're going to have to do what we can to find out why Brandon Lyon isn't throwing the ball like Brandon Lyon can."


text:
After only one term as Cook County Board President, Todd Stroger will have to face some tough competition for his re-election. Big names like Danny Davis, Toni Preckwinkle and County Circuit Court Clerk Dorothy Brown are lining up against him.
Stroger, named Board president after his father John, who had been Board president for 12 years, resigned from the office in 2006 after experiencing a stroke, is often considered a lame duck.
Before assuming his current post, Stroger had been State Representative from 1992 to 2001, when he was appointed by Mayor Richard M. Daley to replace Ald. Lorraine Dixon (8th).
In 2007, Stroger increased the county tax by one percent and vetoed an effort to repeal it.
Published at 12:03 PM CST on Nov 2, 2009 | Updated at 3:33 PM CST on Nov 10, 2009


text:
JOURNEYS; A Keys Resort Sells A Piece of the Nest
By CHARLES PASSY
Published: January 28, 2005
ROGER BERNSTEIN has long considered the Cheeca Lodge & Spa, a tropical-themed resort on this famed Florida Keys getaway, a kind of home away from home, an upscale retreat he visits every few months to ''drink lots of fruity drinks'' and work on his tennis game. So, this last year, Mr. Bernstein, a Miami lawyer, decided to take his passion for the place to the next level.
He bought it.
Well, at least a small piece of it. Mr. Bernstein purchased a $355,000 studio unit -- one of 92 ''resort residences'' the decades-old Cheeca is selling as part of its conversion from a traditional resort into a condominium hotel. It's a decidedly different sort of second-home ownership: Mr. Bernstein and his wife, Erica, and two children -- a third is on the way -- won't get to personalize their unit or even put in a washing machine. And they can only use it 28 days a year; the rest of the time, they will be required to place it into the resort's rental pool.
Still, he and his family get to swim in the resort's lagoon, get mud wraps in the spa and play golf on the nine-hole par 3 course. Mr. Bernstein is also betting that his property will appreciate. In the Florida Keys, where there's a limited availability of real estate because of restrictions on development, housing prices have soared -- more than 30 percent in 2003, according to Monroe County officials. ''My philosophy is investing in something you can enjoy,'' he said.
He is not alone. In recent years, one of the hottest trends among luxury resorts has been to develop some kind of ownership program, offering high-end ''fractionals'' (fancy time-shares), condominiums or even houses. Some projects mirror the Cheeca model -- a legendary property converting part of its rooms to condos. Others are being built from the ground up as condo hotels. Among the resorts in Florida alone that have condo projects in the works are Miami Beach's Fontainebleau Hilton, the Venetian Grand Resort in Orlando and Fort Myers Beach's Pink Shell Beach Resort. But the phenomenon has spread to other locales, including Las Vegas (MGM Grand Hotel) and Chicago (Trump International Hotel). Even the 200-year-old Greenbrier, in West Virginia, is getting into the ownership game, establishing the Greenbrier Sporting Club, a luxury development connected to the property that will eventually include 500 homes; lots range from $400,000 to $2 million.
Even before its recent renovation, Cheeca was distinct among Keys properties for its size -- a roomy 27 acres -- and the fact it offered hard-to-find amenities on this slender chain of islands like a golf course designed by Jack Nicklaus and a sandy beach built up on the notoriously rocky shoreline. Then there's the blue-green water that has always beckoned snorkelers, scuba divers and sport fishermen to the Keys.
The location ''is an hour and a half away from Miami Beach, but it's like being on a Caribbean island,'' said Cecilie Jorgensen, who with her husband, Kent, bought two adjoining units at the hotel for $1.1 million last year. Adding to the feeling of remoteness is the fact that there's only one road that connects the Keys to the mainland. Which may explain why some Cheeca buyers opt to arrive on the resort's helicopter, which lands on the golf course.
THE lodge, now managed by RockResorts, was built in the early 1960's after a hurricane destroyed its predecessor, the Olney Inn, where Harry S. Truman was once a guest. The name was derived from a merger of the names of the two new owners, Cynthia (better known as Che-Che) and her husband, Carl Twitchell (an heir to the A.& P. supermarket fortune).
The resort soon took on something of a celebrity cachet. Frequent guests included Sam Snead, Ted Williams and Bing Crosby. More recently, former President George Bush has often been a guest -- so much so that the resort holds an annual bonefish tournament in his honor.
But in the last decade, as luxury resorts proliferated and spent millions trying to top each other with new amenities, it also became clear that Cheeca was no longer meeting the high-end standard. You can tell as much today when you step into one of the resort's remaining unrenovated rooms: the yellow wallpaper would be more appropriate in a Florida motel room of the mid-50's than in an upscale resort of the new century.
The rest of Cheeca, however, tells a much different story.
With an architectural style that blends West Indian and Floridian influences, the resort, consisting of a main lodge, several two-level buildings and beach bungalows, has a relaxed feel -- what Cheeca executives refer to as ''barefoot elegance.'' And they mean it. Even though a weekend stay here during peak season can easily run $1,000 or more -- for nonowners, that is -- the dress code consists of little more than sandals and shorts (or a one-piece and sarong). And the otherwise formal dining room does not require jackets for men.
The renovated rooms have been done up with mahogany furniture in the bedrooms, Italian marble in the bathrooms and a 42-inch plasma television for every guest's viewing pleasure. The spa -- added in 2001 -- has an adult-only pool, with cabanas that rent by the day. The 1,200-foot beach is lined with hammocks, perfect for a midday siesta.
Best of all is a pier that extends 525 feet into the Atlantic -- so far out that you'll feel you're already on one of the resort's rental miniboats.
CHEECA'S makeover and its conversion to a condo-hotel property are inextricably tied to each other. In a post-9/11 environment, hotel and resort developers have found it extremely difficult to secure loans for new construction or renovations. So, they've sought another way: selling off their properties room by room to individuals. While it means forsaking a share of the revenue, it also reduces the burden of debt.
Jerry Johnson, the managing partner of the group that owns Cheeca, said that the bill for renovations would hit ''at least'' $40 million. ''It wouldn't be economically feasible to do that'' running Cheeca as a ''straight hotel,'' he said.
Buyers, of course, get a portion of the income from their rooms -- rates run from $295 to $795 a night, depending upon the season. There are downsides, too. For starters, condo-hotel living means hotel living, so items like extra closets and washers and dryers are out of the question. Units cannot be customized or decorated to an owner's taste. And there is no predicting the long-term income potential. ''This is not for the faint of heart,'' said Bill Dougherty, sales director for the Cheeca condo operation.
Still, he has already sold more than 60 of the 92 available units, with little more marketing effort than a few mailings to former guests at Cheeca. Mr. Dougherty suspects a number of buyers just like owning a piece of a classic resort like Cheeca -- in the same way they might have liked owning a piece of a winery or a prize-winning thoroughbred in years past. ''It's an ego thing,'' he said.
Or, in the case, of Mike Miller, an entrepreneur based in Ohio, it's simply an attractive business proposition. Having already bought condo-hotel units elsewhere in Florida, he decided to add to his portfolio and buy one at Cheeca -- sight unseen -- with a business partner.
Then, Mr. Miller finally got around to seeing the resort in November when he came on a vacation with his wife. After a few days walking up and down the beach and lounging in those oceanside hammocks, there seemed only one thing left for the couple to do. ''We liked it so much,'' he said, ''we bought another unit for ourselves.''
Photos: POOLSIDE -- Built in the 1960's, Cheeca Lodge & Spa, in the middle of the Florida Keys, has been undergoing a $40 million renovation, financed partly with condo sales.; A LAGOON OF ONE'S OWN -- The Cheeca Lodge is among a growing number of luxury resorts and hotels around the nation that are offering some form of ownership. (Photographs by Mike Hentz for The New York Times); SHARING TIME -- Erica Bernstein, seated above right, and family members in her studio at Cheeca. Units are available for rent when the owners aren't there. The lagoon, right, provides a quiet haven for children. (pg. F7); KEY PERKS -- A great egret (at left as well) graces the resort's 525-foot fishing pier.; REJUVENATION -- The spa at the Cheeca Lodge was added four years ago. (Photographs by Mike Hentz for The New York Times)(pg. F1)
Map of Florida Keys highlighting Cheeca Lodge & Spa. (pg. F7)


text:
dafman: Hi - is ICS being rolled out selectively to Vodafone users? When I connect my Vodafone S2 to Kies, it says I am running the latest firmware (Gingerbread), and the 'check for update' function on the phone' says 'no update available.'
Yet other Vodafone S2 users are currently able to upgrade ... ?
XWKG3 is still the latest official Vodafone NZ firmware. It's possible that other people you know are running custom or overseas ROMs, not anything that Vodafone have approved.


text:
PHILADELPHIA — The Winnipeg Jets went with speed and skill in the opening round of the 2014 NHL Draft, choosing winger Nikolaj Ehlers of the Halifax Mooseheads.Follow @SlamSports
Ehlers, a Danish winger, had 49 goals and 55 assists for 104 points in his first season in the Quebec Major Junior Hockey League.
A skilled finisher, Ehlers is listed at 5-foot-11 and 162 pounds.
In the Winnipeg Sun draft preview last week, Mooseheads assistant coach Jim Midgley said Ehlers has speed similar to New York Rangers winger Carl Hagelin with more dynamic offensive ability.
"Biggest strength without a doubt is his speed. Loves to take puck on his off wing and cut across the offensive zone. Watching the Stanley Cup finals this year he reminds me a bit of Hagelin from the Rangers," said Midgley. "He can separate himself from defensive to offensive so fast. Still
only 160 pounds but does not shy away from the North American game. He actually got better as the year went on.


text:
Cloud Computing's Software-as-a-Service (SaaS) Delivery Model Benefits Technical Courses in Higher Education
Software-as-a-Service (SaaS) is a form of cloud computing that relieves the user of the burden of hardware and software installation and management. SaaS can be used at the course level to enhance curricula and student experience. When cloud computing and SaaS are included in educational literature, the focus is typically on implementing administrative functions. Yet, SaaS can make more immediate and substantial contributions to the technical course content in educational offerings. This paper explores cloud computing and SaaS, provides examples, reports on experiences using SaaS to offer specialized software in courses, and analyzes the advantages and disadvantages of using SaaS at the course level.


text:
www.bungie.net | halo.bungie.net | bungiestore.com
Add Relevant Tags:
Do you agree with any of the tags already listed? If so, click the plus icon to
the left of the tag to apply the tag yourself, increasing its significance. Every
tag you apply will be added to your tag history.
Comments disabled for this post, thread is locked, deleted, or you are not logged in with an account with a linked gamertag.
Forged in the flames of passion and perseverance. Go forth and represent.MARK VIC.Q.B.E.V.A.E.O.D.HAYABUSASECURITYSCOUTMARK VROGUER****INVISThe Recon Doom Button[Edited on 08.11.2008 10:20 AM PDT]
How did you do that?
used the bungie chest, gives flame
© 2017 Bungie, Inc. All rights reserved.


text: Yep. You knew it was coming, so don't look so surprised. In roughly one week's time, SyFy will debut director Steven C. Miller's "Scream of the Banshee", a film that will be distributed on DVD and Blu-ray as a part of the "After Dark" series. I'm honestly not sure what I think about the film, though I am intrigued just enough to consider giving it a once-over when it hits the digital airwaves on March 26th, 2011. If nothing else, you'll be able to tell all your friends that you saw SyFy's 200th original movie the day that it aired. And everyone will be impressed. Trust me on this one. I know all about these things.


text:
Home |
Accessibility |
Sitemap |
Text Size A
Tel: 01709 820000
Our website uses the access key system to help you move around the site using only your keyboard.
In most web browsers, you can use access keys by pressing the 'ALT' (CTRL on a Mac) button on your keyboard plus the key that corresponds with where you want to go, these are listed below.
S - Skip navigation
1 - Home page2 - News Stories3 -
Site map4 - Search8 - Terms and conditions9
- Feedback form0 - Access key details
The Web Team
Telephone: 01709 426256
or 01709 426257
or email@example.com
Rotherham HospitalMoorgate RoadRotherham S60 2UD
Data Protection |
Disclaimer |
Equality |
Freedom of Information |
Publication Scheme


text:
The Armourlite Professional Watches are durable timepieces with a shatterproof crystal resting on a stainless steel case and kevlar band for ultimate durability. This professional watch is durable and versatile with date function and tritium illumination for clear visibility in the lowest of light conditions.
Tax is only charged if shipping to California. Visit our Shipping Info page for additional information.
We honor returns within 30 days from the original delivery date and offer free exchange shipping. Some restrictions do apply for built-to-order items, or very large items like furniture.
For additional details, or to initiate a return, please visit our Returns Page.
*Please note that while we do our best to have the most up to date product imagery, in-line changes will happen with brands and the actual product shipped may differ slightly.


text:
Collapse/Expand Topics
12:46:30 AM Oct 19th 2010
edited by Madrugada
edited by Madrugada
Moved a bunch of examples that amounted to "[Character] has decent hygiene by modern standards." over here. The page was getting swamped in them. Comics:
- "Ordeal", an issue of Hellblazer, showed Eve (as in "Adam and...") having clean-shaven legs at the dawn of time. (Then again, seeing as how she literally began her life as an adult, this could have been Hand Waved as God's doing.)
- Possibly leg hair, like painful childbirth, is another punishment for the original sin.
- Notice how everyone in Robin Hood: Prince of Thieves was well-scrubbed and had shampooed hair? Mmm-hmm.
- In Pirates of the Caribbean: At World's End, Keira Knightley's legs are perfectly smooth.
- In Braveheart, William's wife has perfect hair.
- In medieval England, lice and other horrible parasites were common to the point of being inescapable. Despite this, the sexy, smooth-legged Maid Marian in The BBC's recent Robin Hood series looks like she's just walked out of a shampoo commercial. As do Arthur and Morgana in Merlin.
- Little House on the Prairie was infamous for its 1970s male hairstyles in the 1870s/1880s, especially Michael Landon's perm. The real Pa had a thick beard, yet Landon is smartly clean-shaven.
Collapse/Expand Topics


text:
I've heard of woofers and tweeters. Is that a "meower"?
You are here
Many Stereophile reviewers are cat lovers, but none of our feline fraternity is as bold as Wes Phillips' Bagheera. I was measuring the YGA Anat Reference's in-room response last weekend, to accompany Wes's forthcoming review in our March 2009 issue, when Bagheera suddenly appeared on top of the left-hand speaker. One second nothing - the next, added mass damping courtesy Bagheera, with no visible transition! Good thing I had my cellphone on me to document her disregard for gravity.
How'd That Happen?
John Atkinson | Nov 10, 2008
Views: 2607
Dimensions: 431x604
Size: 264kb
Filed Under: The History of Stereophile