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Considering cutting Venice out of our honeymoon itinerary for October 2013...
We only have 9 nights between Switzerland, Milan (both which can't be taken out of the itinerary) and Venice and although I would like to go to Venice, would it be better we stay in 2 rather than 3 locations (start of a 4 week honeymoon after a long haul flight).
Although I would like to go, because of the uniqueness of Venice and because it is meant to be romantic, I am worried it will just be tiring!
Will we regret cutting it out?
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Should we cut Venice out of our itinerary??
Considering cutting Venice out of our honeymoon itinerary for October 2013...
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Yes. Venice is unique and perfectly suited to a honeymoon, esp. in Oct as some of the maddening crowds have gone home.
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Venice would be probably be the last thing I would cut, sure not the first on a four week trip.
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Thanks guys. Why do you say that Sassafrass?
If we do go we will have 4 nights in Switzerland, 2 or 3 in Milan and 2 or 3 in Venice.
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It is, IMHO, the most unique, beautiful and romantic place I've ever been, and still feel that way after six visits. Keep in mind it is a personal bias and others may not see it that way. Why it would be the last thing I would cut is because no words are adequate to describe Venice. The whole little city is a masterpeice. It would be my first place to keep. Choice between Milan and Venice - no competition: four days Venice - one day Milan or just skip Milan, but you said it was locked in. I guess what I am trying to say about the four weeks is that I can't imagine having four weeks in Europe and actually being Italy, and leaving out Venice, yet seeing Milan, especially on your honemoon and if it is your first trip to Italy.
Luckily, you have plenty of time to think and re-think your plans and come up with what is perfect for you.
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If I had to cut something it wold be Milan (primarily a business city) rather than Venice - one of the most fascinating cities in the world.
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I think it is funny that people are telling you how you will feel and what you should do.
You can read up on Venice. There are, in fact, "words to describe it" which will give you a very good idea of whether you will regret going there when you are exhausted or would rather see it no matter what. A great many people do not enjoy Venice and are even disappointed by their visit there. (Obviously, the same is true of Switzerland and Milan.) I certainly don't find it romantic, or a place where I would simply want to relax and enjoy intimacy with one other person. The place has become like a theme park.
Like Sassafrass says, the answers you get will be personal bias, based on other people's idiosyncratic reactions. And Venice is one of the few destinations where people will actually pressure you to go, even after you've raised legitimate worries about whether you will have their experience of Venice. Don't ask me why they do this, but they do it repeatedly, and they are less concerned about your honeymoon and how you and your wife will feel than they are about getting a chance to be go into a swoon about Venice on the internet.
Find another way to make your decision based on another discussion with your fiancee about the things you like to do. Switzerland and Venice are very different places, and many people who go to Venice six or seven times would NEVER go to Switzerland. Nothing about Switzerland attracts them. So maybe they don't understand you and your wife-to-be. You can always go back to Europe and see Venice. You can't have another honeymoon, so pick for yourselves.
Have a great honeymoon!
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Sorry! I just realized I was assuming you were a man. Not asking you to tell which. (I'm a woman, in case you'd like to know the gender of people giving you advice.)
If your concern is this:
" I am worried it will just be tiring!"
then discuss with your fiance how you both react to jet lag. Are you doing this right after a big wedding? I know more than several honeymooning couples who rejected the idea of going to Paris or Venice or doing anything but a scenic destination after their wedding because they so much just wanted to relax, sleep in, and be someplace in nature, not around man-made things. And they don't want to switch hotels a lot.
Are you concerned that you will feel obliged to get out of bed and go sightsee all day in Venice? Get a gudebook or look at Wikitravel to see if you think you might feel that way. Some people go to Venice and take no interest in anything except taking pictuers and shopping and eating, and they just love "being" in the antique lagoon city.
If you were imagining your honeymoon as being secluded, Venice can get pretty crowded, but in October, it will be less bad. If you were picking Milan to go dancing, you've got the right idea. You won't find it in Venice, or anything very youthful there.
Also ask yourself and your fiance whether, if you decide to keep Venice in the plan, if you get there and it is raining heavily, you will regret it. Would you like your first trip to Venice to be about Venice, and your honeymoon to mainly be about each other?
You have time to decide between the two of you. Good practice working things out without involving other people when it comes to being married!
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Venice is the most beautiful place in the entire universe, even GOD couldn't even dream to ever create it, and you plan to leave it out of you itinerary?!?
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Just to clarify my gender, I'm male.
I struggle to think of Milan as honeymoon material. I could think of Switzerland as honeymoon material if I could think of anywhere romantic in the country, possibly the countryside around Mont Blanc, straw farms etc. Venice on the other hand is a unique experience, with fine views, a constantly changing vista and apart from restaurants some of whom are rip-off merchants (but not all by any means).
Now this whole thing about finding Venice tiring. Well there can be a bit of walking, but what else were you going to do in Switzerland? And Venice has taxis and public transport just about everywhere, while Switzerland has a lower density of buses and trains.
I'm with foodor, though I don't claim to know what god dreams...
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I,too, am mystified that you can't find time in a 4 week trip to include Venice for 3 or 4 days. You have explained that you have to be in Switzerland and Milan but having visited all 3 locations, I suggest considering minimizing time in Switzerland and Milan to fit in time for Venice.
As lorettajung so forcefully opines, it is funny that people are telling you what you should do. No, they aren't. They are telling you what they would do. As you requested. Only you can decide. Enjoy your honeymoon.
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They are flying into Milan. It's unavoidable. They need to rest.
I think all of you not only claim to know what "god" dreams, you have the even worse arrogance to pretend to know what somebody else should do on their honeymoon. I can think of plenty, plenty to do on a honeymoon than walk.
I guess none of you knowledgeable, well-traveled people have ever bumped into the people who were so disappointed in Venice, maybe just because it is so oversold. I wonder if you have even read all those posts by Venice lovers who swear up and down that the WORST introduction to Venice is a short visit, jet-lagged.
Rainy day in Venice jet-lagged? Give me the pristine air of the unspoiled Alps.
You've asked a question for which there is no factual answer. Such questions attract gurus -- so watch out!
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loretta, take a chillpill. This whole board is made up of opinions and most know that.
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(Actually, that may be unfair to gurus. It attracts religious fanatics, shouting all their certainties.)
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Lorettajung If you visited Venice with one those tour groups, being herded around like sheep for a few hours and then left the city, then yeah thats the impression you'd get
Some of us choose remote hotel and apartment far from San Marco or Rialto and stay for days or even weeks.
By the way, I'm in Venice right now for a week, my 4th visit here
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Well, I like Venice AND Switzerland. And both more than Milan. I would take time from Milan, if possible, to have longer in Venice. And when I was IN Venice, I'd be wandering around the back streets and taking the boat to the islands, rather than fighting the crowds around St. Marks and the Rialto. There will be crowds there, there were crowds there in November, but it was whisper quiet elsewhere.
@Lorettajung - I see you are new here. Perhaps you could keep quiet and read for a while. Then you will discover that all anyone can post is their own opinion - aside from stuff about train times and hotel costs.
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October is not the best time for Switzerland. It's between seasons; no snow yet. Some hotels close; they do maintenance on the lifts, etc.
I'm on the Venice bandwagon. It's one of the most beautiful cities in the world. More beautiful than the photos. Venice itself is the main sight to see, and the most appropriate sight-seeing there is wandering around getting lost. Not too strenuous for exhausted honeymooners.
So I agree with the majority of posters. Minimize your time in Milan in particular (not a relaxing place) and don't omit Venice.
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thursdaysd, she is not a new poster, just using a new screen name. Perhaps the editors know why.
keedm002, what exactly is your itinerary in those first 9 days? Does your long-haul flight land in Milan, or are you transitting through Milan on the way to the next destination of your itinerary? Or is there another reason why Milan can't be removed?
FWIW, I like Milan more than most on this board and am not as crazy about Venice, but on a honeymoon I'd much rather be in Venice. No contest.
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I like Milan a lot, and Venice. I'd drop Switzerland!
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No, not new at all, and she is using 3 new names just invented in the last 2 weeks. Can someone tell me why?
It is hard to miss the tone.
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Who is it? I thought if you were banned, you were banned.
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Ok, I'm on the bandwagon too. Of your three destinations in nine days, I also would drop Switzerland and Milan before Venice (I've been to all three, though not everywhere in Switzerland). But of course, it depends on the two of you, and what you enjoy.
Switzerland: Beautiful, mountains (depending on where you are), but the off season. We visited the Dolomites (Italy) in late September once, and it was a little too quiet for us, as a lot of places were shut down between seasons. I'm assuming your four nights/days would be spent in the mountains, not in a city (Interlaken, Lucerne, etc.) Will be colder, I'm guessing, than your other destinations.
Milan: We made numerous trips to Italy in and out of the Milan airport before we actually visited Milan - and then, it was due to a work commitment for my DH. To my surprise, I liked the city - not so touristy, lots of good cafe and people-watching, and several very good smaller museums (I'm an art buff). And the Duomo and Last Supper were as wonderful as I'd heard they were. But Milan is nothing compared to Venice, unless it's your heart's desire to see the Last Supper.
Venice: We keep returning, and every trip has been in the sholder season, so fewer other tourists. My favorite thing is to just wander the streets, admiring the old buildings and their reflections in the narrow canals. Also lots of great art, in museums, churches and other buildings (if you're an art buff). Piazza San Marco is packed with tourists most of the time, except before 8 am or after 11 pm or so. But we've found plenty of other places in the city that are much quieter.
So bottom line, yes 3 different hotels in 9 days/nights is moving around a bit more than you might like, but it sounds like you're committed to Switzerland and Milan. So shorten your time in those two locations, and add that time to Venice - depending on YOUR interests.
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Venice is a good place to relax since there is no vehicular traffic with noise which wears me out. I think cities busy with car/truck traffic are tiring because they are noisy and chaotic.
The area around St. Mark's square is very busy and filled with people. All you have to do is walk a few blocks away and everything becomes serene. The water laps at the buildings and the gondolas glide through the small canals. Even the gondola passengers are quiet while they absorb the atmospheric tranquility.
While walking through the small streets at night you become part of the mystery of Venice and can imagine yourself in another era. Sitting in a gondola on a small canal, low to the water, you're enveloped by the buildings.
I can't think of a more beautiful, serene, and relaxing place to honeymoon.
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3 new names? I've only picked up on 2. But unmistakable.
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Not sure where or how lorettajung got the almighty impression that the OP is flying into Milan - he never states that and in other posts, he specifically talks about flying into Zurich with questions as to how to take the train to Milan, so really loretta, do take that chillpill.
My opinion, since the OP asked, is that skipping Venice on your honeymoon will be one of those things you may most regret, if you go that route. Venice truly is magical, a completely unique experiance, and it is definitely NOT a theme park. Go, I say, stay in the nicest place you can afford and enjoy the lovely absence of motor traffic noise, and the moody romantic atmosphere after dark. Venice is definitely a honeymoon kind of place; Milan is not.
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Wow. There are a lot of very odd things being said, particularly by one poster, but one thing I have to speak against:
"if you decide to keep Venice in the plan, if you get there and it is raining heavily, you will regret it"
I couldn't disagree more. Rain is always a bummer on a trip, but I can't think of a more romantic city in the rain than Venice.
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Rain in Venice is a great reason to keep ducking in for a latte machiatto or a glass of Schiopettino We were there one year in heavy rains and we had to walk on little ramps everywhere. It was very, very interesting.
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Obviously what everyone is giving you is their own opinion. Why would they give you someone else's opinion.
Only you can decide what you want to see and do.
But, for perspective - I have been to europe more than 90 times between vacations and business trips. Have been to Venice 4 times, Milan 3 times and Switzerland 7 or 8 (can;t remember exactly).
they are differnt places with different activities and vibes. Milan is primarily a business city - and after you see 2/3 major sights - is IMHO not very special.
Switzerland is lovely - but is all about the outdoors and being fairly active - walking if not hiking - and spending time in the mountains and on the lakes and in small cute villages.
Venice is unique in the world. IMHO it is very romantic - except for the most touristed centers in the middle of the day in August - and especially at night can be magical. Much more relaxed than Milan and less physically demanding than Switz.
but only you know what your expectations are.
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On the "theme park" and "touristy" comments about Venice.
Of course, it isn't everybody's thing. I do know a couple of people who thought Venice "old, crumbly, expensive and crowded, with outdated plumbing, dirty canals and bad food." Others on a quick visit see it only as a stage setting.
One great beauty of Venice is the reality of it: the structure, inspiration, design and ingenuity. Behind all the exquisite facades of the buildings is the art and architecture and the insides of churches, basilicas and palazzos. There is the water and quiet and shadows and sunlight that intwine to create a place unlike any other. That is what people rave about.
Venice is a place that induced such excitement, it attracted hoardes of visitors right from the beginning. Just look at pictures and read comments by travelers from previous times.
NeoPatrick, so right about Venice in the rain - romantic and mysterious - tried to capture that in photos and paintings - could never do it.
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I wrote a trip report during our second visit to Venice.
It starts like this:
Lou and I came to Italy in December 2006, for three and a half weeks, and spent six nights in Venice before Verona, Como, Florence, Assisi and Rome. I'd been to Venice before.
I remember Lou asking me "If you could go back to anywhere in Europe, where would you go?" And I always said, "Venice". So in 2006, Venice was the first port of call in the trip, Venice was our introduction to Italy, and I'm so glad we did it that way. See some Venice, and after that, see some Italy.
I remember arriving, and finding our hotel. It was near San Marco, and I'd mapped out in my mind exactly how to find it. Turn right from the Alilaguna ferry stop, past the souvenir vendors, cross the Piazzetta and the Piazza, under the clock tower, first right, 30 yards and we were there. I was so keen to show Venice to Lou, to unroll it like a magic carpet, albeit a carpet supported on wooden piles in the lagoon, a carpet with bumps and lumps and a bit waterlogged, wine stains and not a few blood stains, bare patches and worn threads. I so wanted Venice to deliver on the magic carpet.
la Serenissima delivered.
It seemed like magic. We thought of changing our itinerary, staying for another week or two, and didn't. I'm glad we didn't, because if we'd stayed three weeks, we might have thought that we'd "done" Venice, seen it all. We did the bigger sights, the Baedeker "don't miss this" list of attractions, and didn't really see Venice.
When we left, after six days, we were both a bit quiet, biting the bottom lip a little. Before we were half way to Verona on the train, I think we'd both decided that we had to come back again, for a lot longer.
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For those counting names, I'm up to 6. Hey, this could be a new Fodors game.
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I will weigh in on this, as I have a somewhat unique perspective on the issue at hand.
First, have been to Switzerland a number of times, and always enjoy it. Beautiful scenery.
Secondly, have been to Milan many times. The first several times were to simply land at the airport and go Milan Centrale to go to Florence or Rome. The past several times, have spent some time there on our way to/from Como and/or Florence. I also have been to see the Last Supper twice and find it inspirational.
Third, have been to Venice twice. The first time, we chose a bad hotel; it was on the Grand Canal, near the Rialto Bridge, but it was a dump and I never wanted to go back. However, this spring, my wife convinced me to give it another try; we stayed at Hotel Al Ponte Mocenigo; it is a 3 star property but is superb. We found many nice restaurants and really enjoyed the sight seeing. I would go back in a heartbeat. So I went twice, had a miserable time the first visit and really enjoyed the second.
My experience may or may not add to the dialog, but wanted to offer a perspective.
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Hi all,
Wow! I have a lot to respond to, thank you all so much for your feedback and thoughts. Firstly, to clear up the Gender issue, I am a female
We will be flying into Zurich (23 hr flight as opposed to 30 into Milan) and arrive on a Tuesday. We are heavily into soccer/football, so watching a game is a must (will either be a Saturday or Sunday night so we will be staying there those two nights as a minimum). I would like to spend the first 4 nights of our honeymoon in Switzerland as it seems relaxing and beautiful (thinking of staying in Vitznau or Weggis on Lake Luzern).
I know Venice is a wonderful place, and very romantic and relaxing. I think the issue is more that I am worried we would be tired. In February we went to Paris and England for a fleeting visit (We got engaged in Paris!), 6 nights in Paris and 4 in England (2 in Morecambe to visit family and 2 in London). We were very tired in London and I don't want this to happen on our honeymoon (I got grumpy!!).
From Milan/Venice, we are spending 4 nights each in Tuscany and Rome, and 6 nights in Barcelona. I know some will say cut time out of Barcelona to add to Venice but we both agree we do not want to cut down our time in Barcelona.
If we spend the 4 or 5 nights in Milan instead of Venice, we would be looking at doing some day trips to places such as Lake Como, Verona etc (any suggestions are welcome). I am looking at staying in the Glamour Apartment Duomo Open Space, which looks like it has wonderful views of the Duomo and would be good for us as we like to eat dinner in our room where possible.
I think we need to think about it some more however our thoughts at the moment are to stay in Milan for longer; I know Venice is a more relaxing and romantic place, however I think it is more relaxing to stay in one place??
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<I couldn't disagree more. Rain is always a bummer on a trip, but I can't think of a more romantic city in the rain than Venice.>
Absolutely. We spent two rainy days in Venice last October, and it FELT like a honeymoon - after 14 years together.
Whatever you choose to do, have a wonderful time.
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It is indeed more relaxing to stay in one place, but not if you're doing day trips! It will be more relaxing to wander round Venice than take day trips from Milan.
Did I gather that you are staying in Milan to watch soccer? Would Barcelona do for that instead?
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We will be doing that in Barcelona as well Thursdaysd
Good point about the day trips, will be something to think about.
My thoughts are in 4/5 nights in Milan: 1 day for shopping, 1 day for walking around/Last Supper/Duomo etc, 1 day for trip to Lake Como. Add in a soccer game and some long leisurely lunches and the time goes quite quickly!!
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Now, on seeing that you are going from Switzerland and moving on to Tuscany, Rome and then Barcelona after Milan, you are right. Adding in Venice would be too much moving around. Go ahead with your own plan and relax in Milan.
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I would never cut out Venice from a honeymoon itinerary. I'd do just about anything to avoid that, particularly just giving up Milan. Venice, to me, is one of the most romantic places on earth.
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StCirq, I so totally agree with you - especially if it were (my) honeymoon! It seems though that other places are a better fit with the OP's interest in Soccer and football?
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If you've traveled before and you know your own temperment and mood, you should go with that. Who wants to argue on their honeymoon? I'd regret that. Reading through this thread, with people saying they can't imagine Switzerland or Milan being romantic, I wonder if some people find Venice so romantic because they don't have romantic imaginations of their own. I've had many highly romantic evenings in both Switzerland and Milan.
The thing about day trips is that you can gear them to your mood and the weather. If you are tired, you skip it. If you are booked into another hotel, it is hard to cancel on a whim. But sure, think about it as long as you need to. People tend to be very inflexible in their thinking about Venice -- about a lot of things, actually. Better not to get that way about any particular place.
The posts are about zeppole -- or stracciatella, vespacurves, vietritiles, zanzere. I lost track. What was unmistakable was taking off another Fodor's poster trying to paint a newbie as an idiot for worrying they might be moving around too much on their honeymoon to enjoy an important place like Venice. As for being banned, plenty of banned Fodor's posters come back on the board. It's been funny to watch how many people were agreeing with zeppole when they didn't know vespacurves was zeppole. But zeppole always posted under a couple of names. I wondered if the editors didn't care because they quoted her so much in the guidebooks. Or maybe they've got better things to think about. I hope there isn't going to be another witch hunt trying to ban multiple accounts. I don't want to start memorizing passwords and e-mail accounts. I was never sure why zeppole was banned in the first place, given the amount of daily abuse on the board from other posters. Looked like maybe it was because she scolded bobthenavigator for recommending to newbies his relatives trip reports or his own photos without revealing to the newbies his connection, but most people don't think that was kosher of bob to do. So who knows?
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You mean that aguaminerale isn't Zeppole? Hmmm. Her identical twin?
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I'd cancel Switzerland and Milan AND any other city in your list before I'd even consider cutting Venice out.
Venice is THE most romantic destination in the world, no other place comes close
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Hi to keedm002 and welcome.
I think you could trim Milan to 1 or 2 nights and still see great things there. You mentioned Lake Como in a second post? In my opinion, you should read about Venice and Lake Como and choose one of those for the 3 or 4 days if that is correct about your itinerary.
I'd have a difficult time choosing between them but I don't see how you could miss Venice if this is your first trip.
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You certainly are well up to speed on past history, zeppole, bob, etc., for someone who joined in August.
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I think people who talk about themselves in the third person are weird.
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Cut Venice from your itinerary?
What kind of Podsnappery is this?
Are you mad? Are you as daft as a cooker?
Venice is probably one of the most romantic cities in the world, and you will be going at an ideal time, after all the Summer cruise-ship tourists have left their snap-snap- snapping of photos of Piazza San Marco behind.
Why do you want to go to Milano?
Do you plan on shopping for nibbles at Peck? Cashmere scarves at Loro Piana? A bespoke suit at Battistoni?
Most of Milano was bombed during WWII so the city doesn't have the atmosphere and architecture of a place like Venice.
Where are you going in Switzerland?
Switzerland is a big place and is as varied as the US in terms of regional culture and topography.
Now, Miss Thing, if I were going to Switzerland on a romantice honeymoon, I would prolly hit up Luzern and the Bernese Oberland--especially Wengen.
Really, though, sweetie darling, if you want travel advice here from those us who come down from Mount Fodorolympus, you have to try harder and give us much more to go on.
The Great and Fabulous Thingorjus
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Over two dozen responses telling the OP why people would choose Venice. The OP asked a question. Most (not all) of the answers were similar, but not what the OP really wants. If something takes that much convincing, then it probably isn't a good choice for the OP. I realized that it was silly, unreasonable and a waste of time on my part to try and convince the OP when her priorities and interests are different (not better or worse) than mine.
To the OP: you can always come back to Venice for an anniversary trip or second honeymoon. For now, you are young and it is your trip. Enjoy all your games, long lunches, shopping etc.
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Thanks Sassafrass. I guess the thing is - I know (or from what I hear) Venice is beautiful, incredible, unique and romantic. But I was trying to decide whether dividing 5 nights between 2 locations in a 4 week honeymoon is worth it to see Venice. We have talked about it and decided although Venice is obviously a must see, the added travel/checking in and out and hassle that goes with moving around too much does not make for a relaxing honeymoon! We will definitely be back, but it may be 10, 15 years, and then that will be great as we can take our (future) kids with us.
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Keedm002, Trying to convince me to go to a soccer game, no matter who was playing and if the game was free, would be a waste of your time. I would not walk across the street to see the game. Yet, I went hours out of my way on one trip, just to stash my luggage and have a few hours walk in Venice. That is how much I love Venice. It is very difficult for people (like me and other posters, I am sure) who are passionate about something to accept that someone else may have other passions. Do I think you are making a mistake? Absolutely, but that is my own bias based on my personal interests, not yours.
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Keed, you know your mind and evaluated the answers. I hope you have a great honeymoon and best of luck in the future!
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This not for the OP, but for others who might come to this thread. I collected some photos that I took on two different trips in May (2008 and 2011) to address the recurring issue of "But Venice is so crowded!" Check them out at http://flic.kr/s/aHsjwxKYeQ
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<< The OP asked a question. Most (not all) of the answers were similar, but not what the OP really wants. >>
I don't believe that simply saying yes or no is an adequate answer. I answered no - do not cut it out but did not spell out the word no - I responded with the reason why not to drop Venice.
Perhaps I wasted my time as well typing a considered response when I could have given a simple NO.
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Hi Adrienne,
All your assistance and others helped us understand why we would want to keep Venice in our itinerary, and why we wouldn't. It has helped me make a decision based on all the descriptions of Venice, and my own thoughts and interests/priorities.
From such assistance, I have decided although Venice is probably more romantic, we would prefer to spend 4 nights in Venice, and have the chance to have a day or 2 of shopping, to buy food to take back to our room and relax, and of course a chance to see a football game. I don't want to rush the time in Milan in order to rush my time in Venice as well, despite how beautiful it is.
The irony is that if I weren't on my honeymoon I probably would go to Venice! But I need it to be a relaxing holiday (I wont have any annual leave left when I get back and I work full time + run our soccer coaching business). If it weren't for the soccer, we would choose Venice over Milan but that is not the case so based on all your helpful suggestions I have decided it is a better option to spend the nights in Milan.
Thanks again.
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<<We will definitely be back, but it may be 10, 15 year>>
Venice may be underwater by then. I think you have made a very unfortunate decision.
<<The irony is that if I weren't on my honeymoon I probably would go to Venice!>>
Say what????? The very reason to go there is that it IS your honeymoon, and it's probably one of the most romantic places on earth.
I can't imagine soccer trumping romance on a honeymoon, but what do I know?
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Soccer can be important by why go to Milan when Barcelona is out there
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Seattle Michael - thanks for that...Sigh...We're leaving Monday for Venice - a lifelong dream!
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"I can't imagine soccer trumping romance on a honeymoon, but what do I know?" St Cirq, That is exactly what I thought, and why I realized the OP had such different interests from me that my recs were of little value.
SeattleM, Beautiful pics!
Hannabilly, hope it is magical for you.
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I'm glad you've made the decision that suits both of you. The romance of the occasion is between the two of you and that can be found just about anywhere; it is not dependent on your surroundings but on yourselves. I hope you have a beautiful wedding day, honeymoon and married life!! Cheers to you!
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what st. cirq said - you'll always have serie A, la liga etc but you won't always have Venice. a few more years and it may be gone.
and with your itinerary, you can have both! [and being a footie fan myself, i understand why you want to go to the games, but I love venice too].
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Well, Fodors is nothing if not full of animated and passionate opinions.
I'm glad that you are working things out for yourself as a result of posting here, but I have some feedback nonetheless:
I am finding your question a challenge to answer because you keep giving out critical information in dribs and drabs. Such as, where are you going the rest of the 4 weeks? Thus far, you have mentioned Switzerland, Italy, and Barcelona (I'm still unclear as to how you are going to link to Barcelona - it will make a difference to my answer.) What stands out for me is that you are wise to have realized that you have to look at your trip as a whole and then decide.
I liked, more than loved, Venice, but I was very glad to have gone (twice, so far) so as to be able to make up my own mind.
So I would advocate it for that reason alone, EXCEPT if I thought I had to twist my itinerary into a pretzel to accommodate it, or if it caused the trip as a whole to be more rushed than I'd like.
Generally, asking questions like this after you've already cemented in critical decisions (like your arrival and departure gateways) is a bit like asking if one should lock the barn door, when the horse is long gone.
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St. Cirq-- lol I got a good laugh from your last comment. You all may not have been successful at convincing the original poster but--- I so want to go to Venice now! Hmm, maybe for my 21 year anniversary next year. Could never quite make it to Italy with the kiddos because it is just beyond our budget. That's another post though. If we do go to Italy, Venice will definitely be on the itinerary!
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Sort of off topic, but...well, we started our international travel a little late, so now, after 27 years together, our hope is that each trip is a honeymoon...just sayin.
So, right now we are just waking up at Sofitel, Heathrow. We chose to layover and get a good rest here, and arrive in Venice mid-day and rested rather than dark of night and crabby. So, look out Venice, here come the Hanabillies!
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All the places on your list are magnificent; you can't wrong in that regard. They all have a lot to offer, and Switzerland/Venice/Milan are each very distinct. And you are so fortunate to have 4 weeks for your honeymoon. Regarding being tired, though, you can minimize this by keeping to about 4-5 destinations over those 4 weeks, booking an apartment or hotel for 5-7 nights each would minimize the packing/unpacking and checking in/out and finding your way to your next destination. That can be a little stressful, plus it takes up your holiday time. The only caution I would have is to check on the weather in the areas of Switzerland you plan to visit as it can get cold there. Even summer is cool there. If I were designing a trip for four weeks, I wouldn't cut out any of the places you mentioned in Italy. I'd probably leave the Spain part for another trip, not because it wouldn't be nice, but due to the geography. Keeping the distances short and the number of stops fewer makes a trip a little more manageable for me.
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Wow, lots of opinions here. Here's my 2 cents. We were in both Milan and Venice during the last week of May of this year. We spent only a day in Milan. While what we saw was pretty industrial, I think the Duomo alone was worth a visit. Can't believe they allow you to climb to the tops of the Duomo unescorted in this day and age. We cut our Milan visit short to spend several days days at Lake Como (1 hour away) which was probably the best part of our 3 week trip to Italy. The scenery was breathtaking and so romantic. The double rainbow over the lake after a brief rainstorm sealed the "romantic" deal. And one of the least touristed places we vistited (I understand this changes as summer progresses). Stayed in Bellagio several days with day trip to Varenna. I beleive Lake Como is on the Swiss border so this may give you a little TINY taste of Switzerland??? never been to Switzerland so I cannot comment on to go or not to go. Venice. Hmmm. It was our least favorite of the cities visited on our trip but I dont want to say this to discourage you. I think our trip was poorly planned. First of all, we thought we would be there just prior to peak season. If this was off peak I do not want to even imagine what peak is like. Perhaps October is considerably slower. I have never seen so damn many tourists!!! And I live in San Francisco! I must caveat this with the fact that we stayed on the Grand Canal just steps from St Marks Plaza which is probably the worst decision if you are crowd averse. We stayed at Londra Palace which was nice enough especially considering the moderate price, but talk about in the middle of everything! This can be good or bad depending on your taste. If you have been to Fishermans Wharf in SF, think SF Fishermans Wharf on steroids! The hoards of tourists, TACKY tee shirt and trinket shops really distracted us from the true beauty of Venice. Kitchen apron's for sale at every corner with blown up shots of David's private parts. REALLY??? I cannot think of anything less romantic. We did wander off the tourist track and started to see what others have eluded to about the romance of Venice but we had a difficult time clearing our palettes of our intial experience. Perhaps if we had had a few more days we may have found the better parts. We did experience the most amazing thunder and lightning storm ever (very romantic ducking into alleys to avoid the downpour). All said, I would consider a return to Venice but it would definitely have to be in the dead of winter/ off peak season. I generally agree with the other posters here suggesting not moving around too much. We thought 3-4 days in a given location was fine for a first trip. Wish we had done less with a week or more in each. Too much time traveling/packing/unpacking vs enjoying. Happy honeymooning Keedm002!
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In Italy we went to Rome, Florence, Venice each for 3 nights. Venice is a pain to get in and out of but is unique and worth seeing.
To me, those are the 3 main cities to see in case you don't get back there. As far as what we want to see when we go back to Italy, probably Tuscany small towns and then drive down to the Amalfi coast stopping in Rome again for the Vatican and the coliseum (want to see them both again)
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"Venice is a pain to get in and out of but is unique and worth seeing."
jp4120, could you clarify that? I can't think of another city in Europe that is more delightful to arrive in. Fly in and take a boat to your hotel! Drive in, park or return a car right at the edge of the city and take a boat. Take a train and step off right on the Grand Canal. To me the boats MAKES it a wonderfully delightful place to arrive in or leave from -- beats taxis and traffic any day!
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NeoPatrick, I too found that an odd statement. Getting into/out of Venice by train is as easy as it gets. Even from the airport is easy. I guess arriving by plane very late at night or a very early departure, after or before the vaporettos are running, might be a bit more problematic, but even then, isn't any more difficult than many cities.
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Getting into and out of Venice IS a pain. Yeah the Alilaguna is awesome, but you still have to drag stuff over bridges. And down calles. And up stairs. I love arriving on the train, but the vaporetto? Not fun with luggage.
I love Venice and spend a lot of time there, but I would not say it is easy to get in and out of, unless you are staying extremely close to a vap stop or have the cash for a water taxi.
Having said that, it is all worth it for a honeymoon trip. Or any trip, really.
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OK, what I consider a pain (needing a boat, having to walk across crowded bridges with luggage, etc) others are saying that is a unique travelers adventure and should not be considered a pain.
I prefer to be able to drive into a city or taxi directly into a city without the hop, skip and jumping required for Venice. Travel into Rome and Florence were much less hassle for me personally. also have traveled into many other cities in UK, France, Amsterdam, Germany and found them easier to get into.
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OK, it's sort of a pain to get into and out of:
a. in that you can't get to the city center directly
b. you do have to walk, with luggage, over bridges (with steps) to get to your residence if you take a vaporetto or the alilaguna
c. there's really nothing romantic or exotic about the vaporetto, in that it's utliltarian transport.
That said, it is a unique place. You're not going to see anything else like it.
BTW, the last time we left, we sprung for the water taxi to the airport. It was worth every penny.
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I am a guru hater.
I hate Florence, too hot, too full of tour parties.
I hate Barcelona.
Etc, etc.
But after 42 years of being in denial. I went to Venice for the first time last October, it was cold, wet and windy......
It is the most beautiful place on earth.
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Just a word to add for OP: when you are ready to go to Venice, the best advice we got was which area to stay in. We stayed in Dorsoduro, which a delightful neighborhood for sightseeing and wandering around. Not to forget trying (and loving) our first Aperol spritz at Bar da Gino,which became our favorite place to stop. We ate at tiny restaurants, loved the food and the TLC.
So when we finally made it over to San Marco, it was a big shock. I couldn't believe the masses of people herding their way through the basilica, ignoring the notices about being quiet and not taking photographs. The mosaics were beautiful, but we just wanted to escape. Much better when we found a cafe on the piazza to sit and have an Aperol, and listen to the competing orchestras in the various cafes around the piazza.
The big surprise in Venice? How quiet it was, with no cars, buses, taxis. It's a wonderfully scenic city.
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Even if you find getting to Venice a pain, I would say it was well worth it.
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Arriving at the Venice train station and walking out to the view of the Grand Canal is one of my most memorable travel experiences. Followed by the vaporetto trip down the Grand Canal.
Another time we flew in. The airplane circled over Venice and the view of the city from the air was marvelous.
In either case I can't say I noticed any huge inconvenience. But I'm used to taking buses and walking.
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LordDaMan wrote:
papadage wrote:
Which is cool and all, but they should have led with something that people use.. like Work or Excel. Very few people use OneNote. I do, and love it, but it's not a killer app for tablets.
Onenote is a killer app for tablets. It's always been a killer app for tablets. It's always been designed to shine on a tablet
It's a killer app for tablets with a stylus, IMO. So, so many times in meetings I could have used it with a thin and light tablet if they were available and not the $1000+ thick and heavy Win7 behemoths.
So...Windows RT does not support a stylus. Yep.

subset: commoncrawl


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iPhone 5 vs. Galaxy S3 – The Ultimate Test [VIDEO]
People are still waiting to get their new iPhone 5's, which makes this experiment somewhat unsettling. Apple and Android users will never meet in the middle. What's better? The Apple operating system or Android? While that's a hot debate and a matter of personal preference, we've got the ultimate test of the iPhone 5 and the Galaxy S3 by Samsung… Will it blend? Meanwhile, for an indepth comparison of the phones, check out DigitalTrends.com.


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Lie-Nielsen Dovetail Marker
Lie-Nielsen's dovetail gauge marks the sloped side line and the square top line without switching tools. One side of the marker is pitched at 1:7 for hardwoods and the other side at 1:6 for softwoods. Made of brass and cocobolo.
Notice to residents of California: Please read our Proposition 65 warning.


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David Moyes blasts Man Utd flops as he looks to splash the cash on big names
DAVID MOYES tore into his Manchester United flops with an expletive-filled rant following their shock FA Cup defeat to Swansea.
The under-fire United boss lost patience with his failing stars and turned on them in the dressing room after their 2-1 loss at Old Trafford on Sunday.
Starsport understands Moyes told his players they have not been good enough this season and accused them of letting themselves and the club down.
Moyes has defended his players in public but finally lost patience, warning them their futures are at stake unless they arrest the slump.
"He went ballistic in the dressing room and ripped into them. He let it be known what he thought"Man Utd source
A dressing room source said: "The manager may have claimed after the game that United played well, but that's not what he told his players.
"He went ballistic in the dressing room and ripped into them. He let it be known what he thought."
Moyes is under pressure to make signings in the transfer window.
A senior United source told Starsport he can spend in excess of £100m if he wants to.
Moyes has given chief executive Ed Woodward a list of targets, but the duo are not interested in short-term fixes.
Moyes sent scout Robbie Cook to Spain last weekend to check on targets, including striker Diego Costa and midfielder Koke, of Atletico Madrid.
But United have given up on Athletic Bilbao midfielder Ander Herrera.
Sunday's cup defeat was only the second time in 29 years they have crashed out in the third round.
So the pressure is on them to bounce back in tonight's Capital One Cup semi-final first leg at Sunderland.
But Moyes will be without Robin van Persie, Ashley Young and Rio Ferdinand, while Wayne Rooney is still doubtful.
Moyes accepts United have struggled and said: "We have to look into a lot of things. Near enough since the start of the season we've never really caught fire."


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In Februarys Texas Monthly, Michael Hall described the inland sea of beer, mountains of litter and fortresses of merchandizing booths that surrounded the Texas Motor Speedway -- a former cow pasture outside of Fort Worth that became the eleventh-largest city in the state during Novembers Dixie 500. If this enthusiasm spreads to non-NASCAR racing, Reliant Stadium can expect commotion that will make the rodeo seem like a tea party at this weekends Grand Prix of Houston.
Even if the Grand Prix cant beat the tailgating that accompanies a NASCAR event, it certainly keeps up in terms of jaw-dropping automobiles. Saturdays Lone Star Grand Prix will feature cars from the American Le Mans Series, based on those outfitted for Frances legendary 24 Hours of Le Mans race. And at todays big event, Grand Prix of Houston, all eyes will no doubt be on the Panoz DP01, the recently introduced engineering marvel that helped Team Australias Will Power win the Las Vegas Grand Prix early this month. They have all the oomph of anything driven by Junior or Gordon -- just without so many brand logos.
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Other happenings include beer gardens, live music, go-kart racing and the Miss Grand Prix of Houston Contest. Its enough to show that NASCAR, despite its financial savvy, cant hold a monopoly on extravaganza.
Fri., April 20; Sat., April 21; Sun., April 22, 7:30 a.m.


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BOSTON (CBS/AP) – President Barack Obama will talk education innovation with philanthropist Melinda Gates and pitch politics to Democratic Party donors in Boston Tuesday afternoon.
Photo Gallery: President Obama's Boston Visit
WBZ NewsRadio 1030's Karen Twomey reports
The president landed at Logan Airport on Air Force One around 2:30 p.m.
He will visit TechBoston Academy in Dorchester at 3:15 p.m. The public school opened in 2002 with money from a foundation headed by Gates and her husband, Bill Gates, the billionaire co-founder of Microsoft.
WBZ NewsRadio 1030's Carl Stevens talks to Mayor Menino about Obama visit
The president also plans to address a Democratic Congressional Campaign Committee fundraiser at the Museum of Fine Arts Tuesday evening.
Tickets for the dinner start at $5,000 per person.
WBZ's Political Roundtable on Obama visit
The school visit is designed to draw attention to Obama's call for the creation of a federal agency designed to pursue breakthroughs in education technology. Obama requested $90 million for the agency's first year in the budget blueprint he sent to Congress last month.
Read: Excitement, Disappointment Ahead Of Obama Visit
TechBoston, a grades 6-12 pilot school within the Boston school district, represents the combined effort of government, businesses, philanthropists and communities. The school integrates technology in all its academic courses and relies on partnerships with a series of high-tech business partners, including Cisco Systems, Microsoft, IBM and Google.
(TM and © Copyright 2010 CBS Radio Inc. and its relevant subsidiaries. CBS RADIO and EYE Logo TM and Copyright 2010 CBS Broadcasting Inc. Used under license. All Rights Reserved. This material may not be published, broadcast, rewritten, or redistributed. The Associated Press contributed to this report.)


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Lewes MP Norman Baker has welcomed news that East Sussex County Council will receive a further half-million pound grant to support the roll-out of superfast broadband.
The money is part of a recently announced £250m of extra government funding nationwide that will help business start-ups and job creation in some of the UK's hardest to reach rural areas.
The investment is a key part of the government's long-term economic plan to secure Britain's future by providing access to superfast broadband, and in allocating funding it has worked to ensure as many families and businesses as possible benefit.
This funding is in addition to the £1.2bn already invested by central and local government and will ensure 95 per cent of UK homes and businesses have access to superfast broadband by 2017.
Locally, East Sussex's 'go e-sussex' project to roll-out superfast broadband across the region is currently well ahead of schedule. Engineers have already installed new fibre cabinets which will bring new areas online and work on the ground has already started in a number of new locations including Newick.
Mr Baker said: "I am glad to see East Sussex County Council is really getting the ball rolling on the local high speed broadband across the area. The lack of high speed internet access in rural locations is an issue that many constituents have raised with me in recent times. Without high quality internet access local businesses are being restricted and residents are being left out of the loop. I hope that this latest funding from the coalition government will quicken the work even further."


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Research Topics
Genomes and Genes
multiple endocrine neoplasia type 2a
Summary: A form of multiple endocrine neoplasia characterized by the presence of medullary carcinoma (CARCINOMA, MEDULLARY) of the THYROID GLAND, and usually with the co-occurrence of PHEOCHROMOCYTOMA, producing CALCITONIN and ADRENALINE, respectively. Less frequently, it can occur with hyperplasia or adenoma of the PARATHYROID GLANDS. This disease is due to gain-of-function mutations of the MEN2 gene on CHROMOSOME 10 (Locus: 10q11.2), also known as the RET proto-oncogene that encodes a RECEPTOR PROTEIN-TYROSINE KINASE. It is an autosomal dominant inherited disease.
Top Publications
Research Grants
Scientific Experts
Detail Information
Publications240 found, 100 shown here
- Diverse phenotypes associated with exon 10 mutations of the RET proto-oncogeneL M Mulligan
Department of Pathology, University of Cambridge, UK
Hum Mol Genet 3:2163-7. 1994..We suggest that specific mutations in cysteine codons 618 and 620 result in MEN 2A or FMTC, but can also predispose to HSCR with low penetrance...
- Pathogenicity of DNA variants and double mutations in multiple endocrine neoplasia type 2 and von Hippel-Lindau syndromeZoran Erlic
Department of Nephrology, Section of Preventive Medicine, Albert Ludwigs University, Freiburg, D 79106 Freiburg, Germany
J Clin Endocrinol Metab 95:308-13. 2010..This observation of coincident DNA variants, both reported as pathogenic, in two known susceptibility genes prompted the question of their pathogenic relevance...
- High penetrance of pheochromocytoma associated with the novel C634Y/Y791F double germline mutation in the RET protooncogeneRodrigo A Toledo
Faculdade de Medicina da Universidade de Sao Paulo, Avenida Dr Arnaldo, 455, 5 degrees andar, Cerqueira Cesar, 012406 903, Sao Paulo, Brazil
J Clin Endocrinol Metab 95:1318-27. 2010..Previous studies have shown that double RET mutations may be associated with unusual multiple endocrine neoplasia type 2 (MEN 2) phenotypes...
- Update multiple endocrine neoplasia type 2Friedhelm Raue
Endocrine Practice, Heidelberg, Germany
Fam Cancer 9:449-57. 2010..MEN 2 gives a unique model for early prevention and cure of cancer and for stratified roles of mutation-based diagnosis of carriers...
- RET codon 634 mutations in multiple endocrine neoplasia type 2: variable clinical features and clinical outcomeMarcia K Puñales
Endocrine Division, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035 003, Rio Grande do Sul, Brazil
J Clin Endocrinol Metab 88:2644-9. 2003..001). Our results suggest that specific nucleotide and amino acid exchanges at codon 634 might have a direct impact on tumor aggressiveness in MEN 2A syndrome...
- Germline RET V804M mutation associated with multiple endocrine neoplasia type 2AH Gibelin
Department of Endocrine Surgery, Jean Bernard Hospital, Poitiers, France
Br J Surg 91:1458-9. 2004
- Pheochromocytoma penetrance varies by RET mutation in MEN 2AFrank J Quayle
Washington University School of Medicine, St Louis, MO 63110, USA
Surgery 142:800-5; discussion 805.e1. 2007The occurrence of pheochromocytoma in multiple endocrine neoplasia type 2A (MEN 2A) carriers varies greatly. This study aims to determine PC expression for specific MEN 2A RET mutations.
- Medullary thyroid carcinoma identified within the first year of life in children with hereditary multiple endocrine neoplasia type 2A (codon 634) and 2BD Zenaty
Paediatric Endocrinology Department, Centre de Référence Maladies Endocriniennes Rares de la Croissance Paediatric Surgery Department Pathology, Assistance Publique Hopitaux de Paris, Robert Debre Hospital, 75019 Paris, France
Eur J Endocrinol 160:807-13. 2009..Early prophylactic thyroidectomy in patients with multiple endocrine neoplasia (MEN) type 2 offers the best chance for a normal life expectancy...
- Evolution of surgical treatment of primary hyperparathyroidism in patients with multiple endocrine neoplasia type 2AAnouk Scholten
Department of Surgical Oncology and Endocrine Surgery, University Medical Center Utrecht, The Netherlands
Endocr Pract 17:7-15. 2011To determine the best surgical strategy for patients with multiple endocrine neoplasia type 2A (MEN 2A) who have primary hyperparathyroidism (PHPT).
- RET mutation Tyr791Phe: the genetic cause of different diseases derived from neural crestEliska Vaclavikova
Department of Molecular Endocrinology, Institute of Endocrinology, Narodni 8, 116 94, Prague 1, Czech Republic
Endocrine 36:419-24. 2009..A rare case of malignant pheochromocytoma in a patient with the Tyr791Phe mutation is presented. This study shows various clinical characteristics of the frequently discussed Tyr791Phe mutation...
- Impact of RET proto-oncogene analysis on the clinical management of multiple endocrine neoplasia type 2Sergio Pereira de Almeida Toledo
Genetic Endocrinology Unit LIM 25, Internal Medicine Department, Sao Paulo University Medical School, Sao Paulo SP, Brazil
Clinics (Sao Paulo) 61:59-70. 2006....
- Polymorphisms in RET and its coreceptors and ligands as genetic modifiers of multiple endocrine neoplasia type 2AFabienne Lesueur
Strangeways Research Laboratory, Cancer Research UK Department of Oncology, University of Cambridge, Worts Causeway, Cambridge CB1 8RN, UK
Cancer Res 66:1177-80. 2006..line missense mutations in the RET proto-oncogene are responsible for the inherited cancer syndrome multiple endocrine neoplasia type 2A (MEN2A)...
- Polymorphisms G691S/S904S of RET as genetic modifiers of MEN 2AMercedes Robledo
Centro Nacional de Epidemiologia, Instituto de Salud Carlos III Centro Nacional de Investigaciones Oncológicas, Madrid, Spain
Cancer Res 63:1814-7. 2003b>Multiple endocrine neoplasia type 2A (MEN 2A) is associated with specific germ-line missense mutations in the RET proto-oncogene...
- Germ-line mutations in nonsyndromic pheochromocytomaHartmut P H Neumann
Department of Nephrology and Hypertension, Albert Ludwigs University, Freiburg, Germany
N Engl J Med 346:1459-66. 2002....
- RET germline mutations identified by exome sequencing in a Chinese multiple endocrine neoplasia type 2A/familial medullary thyroid carcinoma familyXiao ping Qi
Department of Urologic Surgery, The 117th PLA Hospital, Hangzhou, Zhejiang, China
PLoS ONE 6:e20353. 2011..We set out to demonstrate a suitable example of genetic diagnosis of MEN 2A/FMTC (multiple endocrine neoplasia type 2/familial medullary thyroid carcinoma) using this approach...
- Clinical case seminar: in vivo and in vitro characterization of a novel germline RET mutation associated with low-penetrant nonaggressive familial medullary thyroid carcinomaLeonardo D'Aloiso
Unit of Endocrinology and Division of Anatomic Pathology, Istituto di Ricovero e Cura a Carattere Scientifico Csa Sollievo della Sofferenza Hospital, Foggia, Italy
J Clin Endocrinol Metab 91:754-9. 2006..RET mutation analysis provides useful information on the clinical outcome of medullary thyroid carcinomas (MTCs) and the risk of disease in the family members...
- MicroRNA expression profiling in benign (sporadic and hereditary) and recurring adrenal pheochromocytomasZsófia Tömböl
Faculty of Medicine, 2nd Department of Medicine, Semmelweis University, Budapest, Hungary
Mod Pathol 23:1583-95. 2010..MicroRNA expression patterns differ between various sporadic, hereditary and recurring tumors and miR-1225-3p may be useful for identifying recurring pheochromocytomas...
- Cellular effects of imatinib on medullary thyroid cancer cells harboring multiple endocrine neoplasia Type 2A and 2B associated RET mutationsJ W B de Groot
Department of Surgical Oncology, University Medical Center Groningen, Groningen, The Netherlands
Surgery 139:806-14. 2006....
- Multiple endocrine neoplasia syndromes, children, Hirschsprung's disease and RETS W Moore
Faculty of Health Sciences, University of Stellenbosch, 7505, Tygerberg, South Africa
Pediatr Surg Int 24:521-30. 2008..The future appears full of promise and the current evaluation of RET-targeting tyrosine kinase and other inhibitors are of considerable interest in the management of these conditions...
- The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathwayGiuliana Pelicci
Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy
Mol Cell Biol 22:7351-63. 2002..Phosphorylated Rai, however, was not found in complexes with Grb2. We propose that Rai potentiates the MAPK and PI3K signaling pathways and regulates Ret-dependent and -independent survival signals...
- The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysisC Eng
Division of Cancer Epidemiology and Control, Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115 6084, USA
JAMA 276:1575-9. 1996..The purpose of this study was to establish the relationship between specific mutations and the presence of certain disease features in MEN 2 which could help in clinical decision making...
- RET-familial medullary thyroid carcinoma mutants Y791F and S891A activate a Src/JAK/STAT3 pathway, independent of glial cell line-derived neurotrophic factorIvan Plaza Menacho
Department of Medical Genetics, University of Groningen, Groningen, The Netherlands
Cancer Res 65:1729-37. 2005..Distinct activating RET mutations cause multiple endocrine neoplasia type 2A (MEN2A), type 2B (MEN2B), and familial medullary thyroid carcinoma (FMTC)...
- Multiple endocrine neoplasia type 2 syndromes (MEN 2): results from the ItaMEN network analysis on the prevalence of different genotypes and phenotypesCristina Romei
Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
Eur J Endocrinol 163:301-8. 2010..The prevalence of these rare genetic diseases and their corresponding RET mutations are unknown due to the small size of the study population...
- Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2BM Santoro
Centro di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche CNR, Napoli, Italy
Science 267:381-3. 1995..Oncogenic conversion of RET in these neoplastic syndromes establishes germline transmission of dominant transforming genes in human cancer...
- Evidence of MEN-2 in the original description of classic pheochromocytomaHartmut P H Neumann
Department of Nephrology, University of Freiburg Medical Center, Freiburg im Breisgau, Germany
N Engl J Med 357:1311-5. 2007..The presence of germ-line RET mutations in four living relatives demonstrates that the original patient and her family had multiple endocrine neoplasia type 2 and provides molecular evidence that she had pheochromocytoma...
- Multiple endocrine neoplasia syndrome: genetic basis for clinical managementTobias Carling
Department of Surgery, Yale University School of Medicine, New Haven, CT 06510, USA
Curr Opin Oncol 17:7-12. 2005..Improved understanding of the molecular and clinical genetics associated with these lesions will likely enhance the diagnosis and treatment of patients with these diseases...
- Multiple endocrine neoplasia type 2: evaluation of the genotype-phenotype relationshipLinwah Yip
Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Arch Surg 138:409-16; discussion 416. 2003..Subtypes are defined by the presence or absence of pheochromocytomas, hyperparathyroidism, and characteristic clinical stigmas. We hypothesize that specific RET mutations correlate with the MEN 2 phenotype and aggressiveness of MTC...
- Familial prevalence and age of RET germline mutations: implications for screeningAndreas Machens
Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle Saale, Germany
Clin Endocrinol (Oxf) 69:81-7. 2008..The current investigation was undertaken to provide such natural history data which are urgently needed to enable factual decision-making about DNA-based screening programmes for RET germline mutations...
- Multiple endocrine neoplasia type 2Nelson Wohllk
Department of Endocrinology, Hospital del Salvador, Universidad de Chile, Chile, Rancagua 835, Providencia Santiago de Chile
Best Pract Res Clin Endocrinol Metab 24:371-87. 2010..Registry-based follow-up should be mandatory including documentation of short- and long-term outcome in order to provide valid data for future counselling of patients with MEN 2...
- Increased in vivo phosphorylation of ret tyrosine 1062 is a potential pathogenetic mechanism of multiple endocrine neoplasia type 2BD Salvatore
Centro di Endocrinologia ed Oncologia Sperimentale del CNR, , Italy
Cancer Res 61:1426-31. 2001..The more efficient triggering of these pathways may account for the difference between MEN2A and MEN2B syndromes...
- [Germline mutations of the ret proto-oncogene in Chilean patients with hereditary and sporadic medullary thyroid carcinoma]N Wohllk
Sección de Endocrinología, Departamento de Medicina, Hospital del Salvador, Laboratorio IEMA, Santiago de Chile
Rev Med Chil 129:713-8. 2001..Germline mutations of the RET proto-oncogene (cRet) are found in the inherited forms and in some apparently sporadic MTC cases...
- RET genetic screening of sporadic medullary thyroid cancer (MTC) allows the preclinical diagnosis of unsuspected gene carriers and the identification of a relevant percentage of hidden familial MTC (FMTC)C Romei
Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
Clin Endocrinol (Oxf) 74:241-7. 2011..e. gene carriers) who are unaware of their condition...
- RET mutations in exons 13 and 14 of FMTC patientsA Bolino
Laboratorio di Genetica Molecolare, Istituto G Gaslini, Genova, Italy
Oncogene 10:2415-9. 1995..tyrosine kinase gene which is responsible for three different inherited cancer syndromes namely multiple endocrine neoplasia type 2A (MEN 2A), type 2B (MEN 2B) and familial medullary thyroid carcinoma (FMTC) as well as for ..
- Non-invasive prenatal diagnosis of multiple endocrine neoplasia type 2A using COLD-PCR combined with HRM genotyping analysis from maternal serumHada C Macher
Department of Clinical Biochemistry, The Virgen del Rocío University Hospital IBiS CSIC SAS University of Seville, Seville, Spain
PLoS ONE 7:e51024. 2012The multiple endocrine neoplasia type 2A (MEN2A) is a monogenic disorder characterized by an autosomal dominant pattern of inheritance which is characterized by high risk of medullary thyroid carcinoma in all mutation carriers...
- Biological effects of the dual phenotypic Janus mutation of ret cosegregating with both multiple endocrine neoplasia type 2 and Hirschsprung's diseaseElena Arighi
Developmental Biology, Institute of Biomedicine, Biomedicum Helsinki, P O Box 63, University of Helsinki, Helsinki, Finland FIN 00014
Mol Endocrinol 18:1004-17. 2004....
- Somatic mutations of the RET proto-oncogene are not required for tumor development in multiple endocrine neoplasia type 2 (MEN 2) gene carriersR M Landsvater
Department of Internal Medicine, University Hospital Utrecht, The Netherlands
Cancer Res 56:4853-5. 1996..Thus, RET genes with MEN 2-specific germ line mutations act as dominantly transforming oncogenes in vivo...
- Estimated risk of pheochromocytoma recurrence after adrenal-sparing surgery in patients with multiple endocrine neoplasia type 2AReza Asari
Division of General Surgery, Section of Endocrine Surgery, and Department of Surgery, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
Arch Surg 141:1199-205; discussion 1205. 2006Adrenal-sparing adrenalectomy is considered the treatment of choice for hereditary bilateral pheochromocytoma in patients with multiple endocrine neoplasia type 2A (MEN 2A).
- Hyperparathyroidism and multiple endocrine neoplasiaJames P Malone
Division of Otolaryngology Head and Neck Surgery, Southern Illinois University School of Medicine, 301 N 8th Street, Room 5B506, Springfield, IL 62701, USA
Otolaryngol Clin North Am 37:715-36, viii. 2004..Long-term follow-up reveals a high rate of recurrent hyperparathyroidism in MEN 1 despite surgical intervention...
- Multiple endocrine neoplasia type 2A/localized cutaneous lichen amyloidosis associated with malignant pheochromocytoma and ganglioneuromaS Gullu
Department of Endocrinology and Metabolism, University of Ankara Medical School, Ankara, Turkey
J Endocrinol Invest 28:734-7. 2005We hereby present a rare variant of multiple endocrine neoplasia type 2A (MEN2A) associated with a rare skin disease primary cutaneous lichen amyloidosis and discrete malignant pheochromocytoma in both adrenal glands and pancreatic tail, ..
- Localization of medullary thyroid carcinoma metastasis in a multiple endocrine neoplasia type 2A patient by 6-[18F]-fluorodopamine positron emission tomographyLoukas Gourgiotis
Clinical Endocrinology Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA
J Clin Endocrinol Metab 88:637-41. 2003..Here, we report the case of a 42-yr-old woman with multiple endocrine neoplasia type 2A, in whom biopsy-proven recurrent medullary thyroid cancer (MTC) was detected by 6-[(18)F]..
- Multiple endocrine neoplasia type 2: an overviewJessica Moline
Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Genet Med 13:755-64. 2011..b>Multiple endocrine neoplasia type 2A, familial medullary thyroid carcinoma, and multiple endocrine neoplasia type 2B are collectively ..
- Self-association of the transmembrane domain of RET underlies oncogenic activation by MEN2A mutationsS Kjaer
Department of Neuroscience, Division of Molecular Neurobiology, Karolinska Institute, Stockholm, Sweden
Oncogene 25:7086-95. 2006....
- Molecular advances in medullary thyroid cancer diagnosticsRichard A Hubner
Institute of Cancer Research, Cancer Genetics, 15 Cotswold Road, Sutton, SM2 5NG, United Kingdom
Clin Chim Acta 370:2-8. 2006..Mutation analysis of RET in individuals with MEN2 has identified a number of different mutations, and correlation with cancer biology and clinical outcome has led to tailoring of management according to the mutation detected...
- Multiple endocrine neoplasia 2A syndrome: Surgical managementS Simon
Department of Paediatric Surgery, Surgical Clinic of the Friedrich Alexander Universität Erlangen, Erlangen, Germany
J Pediatr Surg 37:897-900. 2002....
- Occurrence of pheochromocytoma in a MEN2A family with codon 609 mutation of the RET proto-oncogenePeter Igaz
J Clin Endocrinol Metab 87:2994. 2002
- A novel Czech kindred with familial medullary thyroid carcinoma and Hirschsprung's diseaseSarka Dvorakova
Department of Molecular Endocrinology, Institute of Endocrinology, Prague 11694, Czech Republic
J Pediatr Surg 40:e1-6. 2005..Inactivating germline mutations in the RET proto-oncogene are detected in Hirschsprung's disease (HSCR). Only in a very small number of families are these 2 diseases expressed together...
- [Genetic screening of multiple endocrine neoplasia type 2: experience of the USP Endocrine Genetics Unit]Marcelo A C G dos Santos
Unidade de Endocrinologia Genética, Clinica Medica, Faculdade de Medicina, Universidade de Sao Paulo, SP
Arq Bras Endocrinol Metabol 50:7-16. 2006..In 50 typical MEN-2 patients analyzed using both methods, we found no false results suggesting that DGGE is a reliable screening method for RET proto-oncogene mutation analysis...
- Functional characterization of the MTC-associated germline RET-K666E mutation: evidence of oncogenic potential enhanced by the G691S polymorphismMaria Grazia Borrello
Operative Unit Molecular Mechanisms, Department of Experimental Oncology, IRCCS Istituto Nazionale dei Tumori Foundation, Milan, Italy
Endocr Relat Cancer 18:519-27. 2011..We have demonstrated that, although RET-G691S is not oncogenic per se, it enhances the transforming activity of the RET-K666E mutant, thus suggesting a modifier role for this functional polymorphism...
- [Prophylactic thyroid surgery]A Frilling
Klinik fUr Allgemein, Viszeral und Transplantationschirurgie, Universitatsklinikum Essen
Chirurg 77:6-14. 2006..Although genetic research on hereditary nonmedullary thyroid cancer is still in progress, initial results indicate the need of prophylactic surgical treatment also for this subgroup of thyroid neoplasia...
- Characterization of the largest kindred with MEN2A due to a Cys609Ser RET mutationCaterina Mian
Endocrinology Unit, University of Padua, Padua, Italy
Fam Cancer 8:379-82. 2009..In conclusion, at variance from what already known, in this large kindred the Cys609Ser RET mutation predispose to a scarcely aggressive, highly penetrant MTC and a low penetrance of pheochromocytoma and primary hyperparathyroidism...
- RET proto-oncogene mutations affecting codon 790/791: A mild form of multiple endocrine neoplasia type 2A syndrome?Oliver Gimm
Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, 06097 Halle, Germany
Surgery 132:952-9; discussion 959. 2002In patients with multiple endocrine neoplasia type 2A syndrome, prophylactic thyroidectomy is generally recommended at the age of 5 to 6 years. Whether this recommendation is justified for exon 13 mutations is unknown.
- RET mutation profile and variable clinical manifestations in a family with multiple endocrine neoplasia type 2A and Hirschsprung's diseaseBarbara Pasini
Department of Biomedical Sciences and Advanced Therapies, Section of Endocrinology, University of Ferrara, Via Savonarola 9, I 44100 Ferrara, Italy
Surgery 131:373-81. 2002..Furthermore, we have investigated polymorphic sequence variants of the RET proto-oncogene...
- Prophylactic thyroidectomy in pediatric carriers of multiple endocrine neoplasia type 2A or familial medullary thyroid carcinoma: mutation in C620 is associated with Hirschsprung's diseaseAndreana Butter
Division of Pediatric Surgery, Sainte Justine Hospital, Montreal, Quebec, Canada, H3T 1C5
J Pediatr Surg 42:203-6. 2007..We reviewed our experience to determine the incidence of medullary thyroid carcinoma with respect to age at surgery, the location of the mutation, and its association with Hirschsprung's disease (HD)...
- Review of multiple endocrine neoplasia type 2A in children: therapeutic results of early thyroidectomy and prognostic value of codon analysisGabor Szinnai
Department of Pediatric Endocrinology, University Children s Hospital, Basel, Switzerland
Pediatrics 111:E132-9. 2003..medullary thyroid carcinoma with persistent or recurrent disease (PRD) in pediatric patients with multiple endocrine neoplasia type 2A (MEN-2A) and second, to evaluate the strength of codon analysis in children with MEN-2A as ..
- Germline RET 634 mutation positive MEN 2A-related C-cell hyperplasias have genetic features consistent with intraepithelial neoplasiaS J Diaz-Cano
Department of Pathology, Tufts University New England Medical Center, Boston, Massachusetts 02111, USA
J Clin Endocrinol Metab 86:3948-57. 2001C-cell hyperplasias are normally multifocal in multiple endocrine neoplasia type 2A. We compared clonality, microsatellite pattern of tumor suppressor genes, and cellular kinetics of C-cell hyperplasia foci in each thyroid lobe...
- Multiple endocrine neoplasia type 2A in two families with the familial medullary thyroid carcinoma associated G533C mutation of the RET proto-oncogeneMelpomeni Peppa
Endocrine Unit, Athens University Medical School, Research Institute and Diabetes Center, Attikon University Hospital, 1 Rimini Street, 12462 Athens, Greece
Eur J Endocrinol 159:767-71. 2008b>Multiple endocrine neoplasia type 2A (MEN2A) is an autosomal dominant hereditary disorder, associated with a cluster of germline gain-of-function mutations of the RET proto-oncogene (RET), mainly in exons 10-15...
- Primary hyperparathyroidism as the first clinical manifestation of multiple endocrine neoplasia type 2A in a 5-year-old childPatrícia Künzle Ribeiro Magalhães
Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Sao Paulo, Ribeirao Preto, Brazil
Thyroid 21:547-50. 2011Primary hyperparathyroidism occurs in only 10%-30% of patients with multiple endocrine neoplasia type 2A (MEN2A), rarely as the sole clinical manifestation, and is usually diagnosed after the third decade of life.
- A novel Val648Ile substitution in RET protooncogene observed in a Cys634Arg multiple endocrine neoplasia type 2A kindred presenting with an adrenocorticotropin-producing pheochromocytomaAdriana B Nunes
Endocrine Genetics Unit, Department of Endocrinology, University of Sao Paulo School of Medicine, 01246 903 Sao Paulo, Brazil
J Clin Endocrinol Metab 87:5658-61. 2002..Both RET variants were present in the father affected with MEN 2A and the unusual ACTH-producing pheochromocytoma. We speculate that the double RET mutation may have modified and contributed to the rare MEN 2A phenotype in the father...
- Novel germline mutation in the transmembrane region of RET gene close to Cys634Ser mutation associated with MEN 2A syndromeM Poturnajova
Laboratory of Molecular Oncology, Cancer Research Institute SAS, Vlarska 7, 83391 Bratislava, Slovakia
J Mol Med (Berl) 83:287-95. 2005..The observed allelic imbalance in favor of mutated allele in pheochromocytoma corresponded to higher expression of the RET gene. These observations confirm the multifactorial process leading to development of MEN 2A syndrome...
- RET codon 804 mutations in multiple endocrine neoplasia 2: genotype-phenotype correlations and implications in clinical managementS Mukherjee
Beaumont Cancer Genetics Program, Beaumont Cancer Institute, William Beaumont Hospital, Royal Oak, MI 48073, USA
Clin Genet 79:1-16. 2011..This review summarizes the genotypic and phenotypic characteristics of RET codon 804 mutation, a prototype for the less well-defined non-cysteine RET mutations associated with MEN 2...
- Surgical management of MEN-1 and -2: state of the artGoran Akerstrom
Department of Surgery, University Hospital, Uppsala, 751 85 Sweden
Surg Clin North Am 89:1047-68. 2009..Prophylactic thyroidectomy based on DNA testing in the MEN-2 syndrome is considered one of the greater achievements in cancer treatment, because it may be performed before thyroid carcinoma development and provides cure for the patient...
- RET genetic screening in patients with medullary thyroid cancer and their relatives: experience with 807 individuals at one centerRossella Elisei
Department of Endocrinology, University of Pisa, Via Paradisa 2, 56100 Pisa, Italy
J Clin Endocrinol Metab 92:4725-9. 2007....
- Age-related neoplastic risk profiles and penetrance estimations in multiple endocrine neoplasia type 2A caused by germ line RET Cys634Trp (TGC>TGG) mutationIoana N Milos
Section of Preventive Medicine, Department of Nephrology, University of Freiburg Medical Centre, Freiburg im Breisgau, Germany
Endocr Relat Cancer 15:1035-41. 2008..These data provide, for the first time, RET C634W-specific neoplastic risk and age-related penetrance profiles. The data may facilitate risk assessment and genetic counseling...
- Modification of multiple endocrine neoplasia 2A phenotype by cell membrane proximity of RET mutations in exon 10Andreas Machens
Department of General, Visceral and Vascular Surgery Pathology, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle, Germany
Endocr Relat Cancer 16:171-7. 2009..Although limited in numbers, these data suggested that membrane proximity is an important determinant of tumor development in carriers of RET mutations in exon 10...
- Prophylactic thyroidectomy in multiple endocrine neoplasia type 2AMichael A Skinner
Department of Surgery, Duke University School of Medicine, Durham, NC, USA
N Engl J Med 353:1105-13. 2005..We sought to determine whether total thyroidectomy in asymptomatic young members of kindreds with MEN-2A who had a mutated allele of the RET proto-oncogene could prevent or cure medullary thyroid carcinoma...
- RET germline mutation in codon 791 in a family representing 3 generations from age 5 to age 70 years: should thyroidectomy be performed?Volker F H Brauer
Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany
Endocr Pract 10:5-9. 2004..To describe a kindred with a rare RET germline mutation in codon 791 and discuss potential management strategies...
- A novel de novo germ-line V292M mutation in the extracellular region of RET in a patient with phaeochromocytoma and medullary thyroid carcinoma: functional characterizationMaria D Castellone
Istituto di Endocrinologia ed Oncologia Sperimentale G Salvatore, CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, L Califano, Universita Federico II, Napoli, Italy
Clin Endocrinol (Oxf) 73:529-34. 2010..In multiple endocrine neoplasia (MEN), rearranged during transfection (RET), gene testing has been extensively exploited to characterize tumour aggressiveness and optimize the diagnostic and clinical management...
- Familial associations in medullary thyroid carcinoma with Hirschsprung disease: the role of the RET-C620 "Janus" genetic variationSam W Moore
Division of Paediatric Surgery, Faculty of Health Sciences, University of Stellenbosch, PO Box 19063, Tygerberg 7505, South Africa
J Pediatr Surg 45:393-6. 2010..Specifically, HSCR-MEN2 cosegregation mostly relates to the cysteine-rich area at the RET-620 (the "Janus gene")...
- Genome-wide copy number imbalances identified in familial and sporadic medullary thyroid carcinomaDeborah J Marsh
Cancer Genetics, Kolling Institute of Medical Research, and Pacific Laboratory Medicine Services, Royal North Shore Hospital, St Leonards, New South Wales 2065, Australia
J Clin Endocrinol Metab 88:1866-72. 2003..Chromosomal imbalances in the MTC cell line TT were largely identical to those identified in primary MTC tumors, consolidating its use as a model for studying MTC...
- RET proto-oncogene in the development of human cancerC Eng
Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
J Clin Oncol 17:380-93. 1999..Whether the presence of somatic RET mutation is associated with a poor prognosis is currently being investigated as another tool for molecular medicine...
- Risk profiles and penetrance estimations in multiple endocrine neoplasia type 2A caused by germline RET mutations located in exon 10Karin Frank-Raue
Endocrine Practice and Molecular Laboratory, Heidelberg, Germany
Hum Mutat 32:51-8. 2011..Our data provide rigorous bases for timing of premorbid diagnosis and personalized treatment/prophylactic procedure decisions depending on specific RET exon 10 codons affected...
- Multiple endocrine neoplasia type 2 RET protooncogene database: repository of MEN2-associated RET sequence variation and reference for genotype/phenotype correlationsRebecca L Margraf
ARUP Institute for Clinical and Experimental Pathology R, Salt Lake City, Utah 84108, USA
Hum Mutat 30:548-56. 2009..The MEN2 RET database (www.arup.utah.edu/database/MEN2/MEN2_welcome.php) will serve as a repository for MEN2-associated RET sequence variation and reference for RET genotype/MEN2 phenotype correlations...
- Guidelines for diagnosis and therapy of MEN type 1 and type 2M L Brandi
Department of Internal Medicine, University of Florence, 50139 Florence, Italy
J Clin Endocrinol Metab 86:5658-71. 2001....
- A RET double mutation in the germline of a kindred with FMTCD K Bartsch
Department of Surgery, Philipps University of Marburg, Germany
Exp Clin Endocrinol Diabetes 108:128-32. 2000Activating germline mutations of the RET proto-oncogene are found in more than 90% of families with multiple endocrine neoplasia type 2a (MEN 2a) and familial medullary thyroid carcinoma (FMTC)...
- Screening of RET gene mutations in multiple endocrine neoplasia type-2 using conformation sensitive gel electrophoresis (CSGE)Marcelo A C G dos Santos
Endocrine Genetics Unit LIM 25, Endocrinology, Department of Internal Medicine, Hospital das Clinicas, University of Sao Paulo School of Medicine, SP
Arq Bras Endocrinol Metabol 51:1468-76. 2007..As to the Val804Met mutation, this method still needs to be optimized...
- Repair by Src kinase of function-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanineMasashi Kato
Department of Immunology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
Cancer Res 62:2414-22. 2002..Finally, endogenous c-Src was shown to promote Y905 phosphorylation of the Y981F mutant in vivo. These results reveal a novel Src kinase-mediated repair mechanism of otherwise function-impaired mutant RET kinases...
- Association of multiple endocrine neoplasia type 2 and Hirschsprung diseaseG Romeo
Department of Pediatric Surgery, Instituto G and University of Genoa Medical School, Italy
J Intern Med 243:515-20. 1998....
- [Multiple endocrine neoplasia: a clinical model for applying molecular genetic techniques]N Wohllk
Departamento de Medicina, Hospital del Salvador, Santiago de Chile
Rev Med Chil 128:791-800. 2000..Some cases of sporadic MTC are actually MEN 2A or Familial MTC after c-Ret testing is done, therefore routine application of this test is recommended in all cases of apparent sporadic MTC...
- Pheochromocytoma in MEN 2A syndrome. Study of 54 patientsJose M Rodriguez
Endocrine Surgery Unit, Virgen de la Arrixaca University Hospital, 30120, Murcia, Spain
World J Surg 32:2520-6. 2008..The aim of this study is to present our experience with this unusual disease, looking for answers to some of these questions...
- Tissue-specific carcinogenesis in transgenic mice expressing the RET proto-oncogene with a multiple endocrine neoplasia type 2A mutationK Kawai
Department of Pathology, Nagoya University School of Medicine, Japan
Cancer Res 60:5254-60. 2000Germ line mutations of the RET proto-oncogene are responsible for the development of multiple endocrine neoplasia type 2A (MEN 2A), an inherited cancer syndrome characterized by medullary thyroid carcinoma, pheochromocytoma, and ..
- Change in the spectrum of RET mutations diagnosed between 1994 and 2006Karin Frank-Raue
Endokrinologisch Humangenetische Gemeinschaftspraxis, Heidelberg, Germany
Clin Lab 53:273-82. 2007..In our series 38.9% of mutations were level 1 mutations, 54.4% level 2, and 5.6% level 3 mutations...
- Prognostic factors of disease-free survival after thyroidectomy in 170 young patients with a RET germline mutation: a multicenter study of the Groupe Francais d'Etude des Tumeurs EndocrinesV Rohmer
Centre Hospitalier Universitaire Angers, Endocrinologie, Faculte de Medecine, Université Angers, Angers 49933, France
J Clin Endocrinol Metab 96:E509-18. 2011..In hereditary medullary thyroid carcinoma (HMTC), prophylactic surgery is the only curative option, which should be properly defined both in time and extent...
- Acceptable age for prophylactic surgery in children with multiple endocrine neoplasia type 2aT Kahraman
Department of Surgical Oncology Head and Neck Surgery, University Hospital Groningen, Groningen, The Netherlands
Eur J Surg Oncol 29:331-5. 2003..Literature regarding the risk and the extent of early surgical intervention is scarce and the optimum age for surgery is still controversial. To optimize management in these young children we evaluate our experience and results...
- The clinical spectrum of multiple endocrine neoplasia type 2a caused by the rare intracellular RET mutation S891AKlaus Martin Schulte
Department of Endocrine Surgery, King s College Hospital, Denmark Hill, London SE5 9RS, United Kingdom
J Clin Endocrinol Metab 95:E92-7. 2010..A strong genotype-phenotype correlation results in major implications for the clinical approach. More information on less common mutations is needed to advance specific guidance...
- Allelic imbalance of the mutant and wild-type RET allele in MEN 2A-associated medullary thyroid carcinomaC A Koch
Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Disease NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
Oncogene 20:7809-11. 2001..Taken together, our results suggest allelic imbalance between mutated and wild-type RET as a possible mechanism for tumor formation in some patients with MEN 2A-related MTC...
- Consequences of direct genetic testing for germline mutations in the clinical management of families with multiple endocrine neoplasia, type IIH P Neumann
Department of Nephrology and Hypertension, Albert Ludwigs University of Freiburg, Germany
- A novel case of multiple endocrine neoplasia type 2A associated with two de novo mutations of the RET protooncogeneA Tessitore
Dipartimento di Biochimica e Biotecnologie Mediche e Ceinge, Centro di Ingegneria Genetica, Universita degli Studi di Napoli Federico II, Italy
J Clin Endocrinol Metab 84:3522-7. 1999We report a novel case of multiple endocrine neoplasia type 2A (MEN 2A) associated with two mutations of the protooncogene RET...
- Gastrointestinal manifestations of multiple endocrine neoplasia type 2Mark S Cohen
Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
Ann Surg 235:648-54; discussion 654-5. 2002..To determine the clinical features, natural history, and role of surgery for gastrointestinal manifestations of the multiple endocrine neoplasia type 2 (MEN 2) syndromes...
- RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2M J Lorenzo
CRC Human Cancer Genetics Research Group, University of Cambridge, Department of Pathology, Cambridge, UK
Oncogene 14:763-71. 1997..In addition, a splice isoform-specific HSCR missense mutation, which does not inactivate the RET kinase activity, decreases the strength of the PTB domain interaction and the level of RET-dependent Shc phosphorylation...
- Hyperparathyroidism in hereditary syndromes: special expressions and special managementsStephen J Marx
Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892 1802, USA
J Bone Miner Res 17:N37-43. 2002..neoplasia underlays most other HPT variants: multiple endocrine neoplasia type 1 (MEN1), multiple endocrine neoplasia type 2A (MEN2A), and hyperparathyroidism-jaw tumor syndrome (HPT-JT)...
- Germline homozygous mutations at codon 804 in the RET protooncogene in medullary thyroid carcinoma/multiple endocrine neoplasia type 2A patientsF Lesueur
Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, United Kingdom
J Clin Endocrinol Metab 90:3454-7. 2005..The activity and (in the case of somatic mutations) timing of these other genetic alterations in the RET gene may explain the wide clinical variability associated with germline mutations at codon 804...
- A new hot spot for mutations in the ret protooncogene causing familial medullary thyroid carcinoma and multiple endocrine neoplasia type 2AI Berndt
Institute for Hormone and Fertility Research, University of Hamburg, Germany
J Clin Endocrinol Metab 83:770-4. 1998One hundred and eighty-one families with multiple endocrine neoplasia type 2A (MEN-2A) or familial medullary thyroid carcinoma (FMTC) have been investigated for mutations in the ret protooncogene in Germany...
- RET-mediated gene expression pattern is affected by isoform but not oncogenic mutationJessica G Hickey
Division of Cancer Biology and Genetics, Cancer Research Institute Queen s University, Kingston, ON, Canada, K7L 3N6
Genes Chromosomes Cancer 48:429-40. 2009..Our data suggest that similar transcriptional programs contribute to all forms of MEN 2 but that differences in target gene expression may contribute to developmental pattern differences observed between RET isoforms...
- Array-comparative genomic hybridization in sporadic benign pheochromocytomasFrancien H van Nederveen
Department of Pathology, Josephine Nefkens Institute, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
Endocr Relat Cancer 16:505-13. 2009..In addition, genes on 21q and 22q might play a more important role in PCC pathogenesis than had been assumed thus far...
- RET proto-oncogene mutations are restricted to codons 634 and 918 in mainland Chinese families with MEN2A and MEN2BYulin Zhou
Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Key Laboratory for Endocrine Tumors, Ruijin Hospital, Jiao Tong University, Shanghai
Clin Endocrinol (Oxf) 67:570-6. 2007..caused by autosomal dominant gain-of-function mutations in the RET proto-oncogene, which includes multiple endocrine neoplasia type 2A (MEN2A), type 2B (MEN 2B), and familial medullary thyroid carcinoma (FMTC)...
- Malignant progression from C-cell hyperplasia to medullary thyroid carcinoma in 167 carriers of RET germline mutationsAndreas Machens
Department of General, Visceral and Vascular Surgery, Martin Luther University, Halle Wittenberg, Halle Saale, Germany
Surgery 134:425-31. 2003..The study objective was to investigate the impact of RET genotype on disease progression from C-cell hyperplasia (CCH) to MTC...
- Cellular effects and antitumor activity of RET inhibitor RPI-1 on MEN2A-associated medullary thyroid carcinomaGiuditta Cuccuru
Preclinical Chemotherapy and Pharmacology Unit, and Nuclear Medicine Unit, Istituto Nazionale Tumori, Milan, Italy
J Natl Cancer Inst 96:1006-14. 2004..Medullary thyroid carcinoma is a component of multiple endocrine neoplasia type 2 or MEN2 syndromes...
- Phenotypic expression of a family with multiple endocrine neoplasia type 2A due to a RET mutation at codon 618S Lindskog
Department of Surgery, Varberg Hospital, Varberg, Sweden
Br J Surg 91:713-8. 2004b>Multiple endocrine neoplasia type 2A (MEN2A) is caused by missense mutations in the RET proto-oncogene on chromosome 10...
- Genotype-phenotype based surgical concept of hereditary medullary thyroid carcinomaAndreas Machens
Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Str 40, D 06097, Halle Saale, Germany
World J Surg 31:957-68. 2007..A comprehensive appraisal of this body of evidence using evidence-based methodology is pending...
- Surgical treatment of medullary thyroid carcinomaM S Cohen
Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
J Intern Med 253:616-26. 2003..Surgical reoperation or conservative observation are the best available options. Diagnostic laparoscopy for liver evaluation is the most sensitive diagnostic test to detect the presence of distant metastases...
- Description of the first two seemingly unrelated Greek Cypriot families with a common C618R RET proto-oncogene mutationVassos Neocleous
Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus
Genet Test 8:163-8. 2004Germ-line mutations of the RET proto-oncogene cause three different cancer syndromes: multiple endocrine neoplasia type 2A (MEN2A), multiple endocrine neoplasia type 2B, and familial medullary thyroid carcinoma (FMTC)...
Research Grants4
- Targeting RET in Lung CancerPasi A Janne; Fiscal Year: 2013..In addition, RET mutations underlie the familial cancer syndromes multiple endocrine neoplasia type 2A (MEN2A), type 2B (MEN 2B) and familial medullary thyroid cancers...
- MOLECULAR CLONING AND ANALYSIS OF HUMAN GENOMIC REGIONSDonald Moir; Fiscal Year: 1990..Identification of the gene for familial polyposis will be based on screening for detectable alterations in the cDNA or the gene in tissues from affected individuals...
- Regulation of Receptor Tyrosine KinasesDaniel Donoghue; Fiscal Year: 2005..Mutations in the extracellular juxtamembrane domain of RET cause multiple endocrine neoplasia type 2A (MEN2A) and familial medullary thyroid carcinoma (FMTC), whereas mutations in the intracellular ..
- PHENOTYPIC AND PSYCHOSOCIAL STUDY OF THE L1307K MUTATIONHenry Lynch; Fiscal Year: 2004....


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